Patent Publication Number: US-2023159518-A1

Title: Crystalline forms or amorphous forms of n-(phenyl sulfonyl) benzamide compounds or its salts or solvates

Description:
FIELD OF THE INVENTION 
     The invention relates to the field of pharmaceutical chemistry, in particular to a crystalline form or amorphous form of N-(phenyl sulfonyl) benzamide compound or its salt and solvant used as a Bcl-2 inhibitor, as well as a preparation method and an application thereof. 
     BACKGROUND OF THE INVENTION 
     Apoptosis is a process of programmed cell death and an essential biological process for tissue homeostasis. In mammals, it has been shown to regulate early embryonic development. Toward the end of life, cell death is a default mechanism by whcih potentially dangerous cells are eliminated such as cells carrying cancer defects. Several apoptotic pathways are known. One of the most important apoptotic pathways involves the Bcl-2 protein family, which is a key regulator of the mitochondrial (also known as “intrinsic”) pathway of apoptosis. See Danial and Korsmeyer, Cell 776:205-219 (2004). BH1, BH2, BH3 and BH4 of structural homologous domains are characteristics of the Bcl-2 family of proteins. The Bcl-2 protein family can be further divided into three subgroups. It depends on how many homologous domains and biological activities each protein has, that is whether it has pro-apoptotic or anti-apoptotic functions. 
     The first subgroup of Bcl-2 proteins contains proteins with all four homologous domains, namely BH1, BH2, BH3, and BH4. Their general function is anti-apoptosis, that is which protects cells from starting the process of cell death. Proteins such as Bcl-2, Bcl-W, Bcl-XL, Mel-1, and BFL-1/AL are members of the first subgroup. The proteins belonging to the second subgroup of Bcl-2 protein contain three homologous domains of BH1, BH2 and BH3, and have effects of promoting apoptosis. The two main representative proteins of the second subgroup are Bax and Bak. The third subgroup of Bcl-2 protein consists of proteins containing only the BH3 domain, and members of this subgroup are often referred to as “BH3-only proteins”. Their biological effects on cells are pro-apoptotic. BIM, BID, BAD, BIK, NOXA, HRK, BMF, and PUMA are examples of the third subgroup of protein family. 
     The disordered apoptotic pathway involes pathologies of many important diseases, such as neurodegenerative disorders (up-regulated apoptosis), such as Alzheimer&#39;s disease; And proliferative diseases (down-regulated apoptosis), such as cancers, autoimmune diseases, and prothrombotic disorders. 
     Downregulated apoptosis (more specifically, the Bcl-2 protein family) can be involved in the onset of cancerous malignancies. Studies have shown, for example, that the anti-apoptotic proteins Bcl-2 and Bcl-XL are overexpressed in many cancer cell types. See Zhang, Nature Reviews Drug Discovery 1:101 (2002); Kirkin et al., Biochimica et Biophysica Acta 1644:229-249 (2004); And Amundson et al., Cancer Research 60:6101-6110(2000). The effects of the disorder are to alter the survival of cells that would otherwise undergo apoptosis under normal conditions. Replication of defects associated with unregulated proliferation is thought to be the starting point of cancer evolution. 
     These findings make possible new strategies for drug discovery that target cancer. WO2018/027097A1 discloses N-(phenylsulfonyl) benzoamide and related compounds for the treatment of diseases, disorders or conditions (e.g., cancer) that respond to BCl-2 protein inhibition, and specifically discloses representative compound: (S)—N-((4-(((1,4-dioxan-2-yl) methyl) amino)-3-nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)benzamide (Compound 1), its structure formula is as follows: 
     
       
         
         
             
             
         
       
     
     However, the current literature including the patent application, mainly reported the structure and pharmacological activity of the compounds without any studies and reports on polymorphs, amorphous and other structural forms. 
     Due to the influence of various factors such as configuration, conformation, molecular arrangement, molecular interaction and eutectic mixtures of molecular structure of solid matter, the arrangement of molecular lattice space is different and two or more different crystal structures are formed. This Phenomenon is called “Polymorphism Phenomenon” or “allomorphism”. “Polymorphism phenomenon” widely exists in solid drugs. Physical and chemical properties between different crystal forms of the same drug can exist differences, such as appearance, density, hardness, melting point, solubility, stability, dissolution, dissolution rate and bioavailability can be significantly different. This phenomenon is particularly evident in oral solid preparations. Further more, the existent forms and quantities of polycrystalline compounds are unpredictable. Different crystalline forms of the same drug have significant differences in solubility, melting point, density, stability, etc., which affect the uniformity, bioavailability, efficacy and safety etc. of the drug to different degrees. 
     In addition to polycrystalline form, some solid compounds may have amorphous forms. The amorphous refers to the structure of some amorphous regions (amorphous regions) of incomplete crystals or forms of some amorphous solids (amorphous regions). For a specific solid drug, the existent forms and quantities of its amorphous form are also unpredictable, and may also have a significant impact on the solubility, melting point, density, stability, etc. 
     Therefore, in the process of new drug research and development, it is necessary to considery multiple factors to carry out comprehensive screening of drug compounds in crystalline forms and amorphous forms. In particular, for the above compound of Formula 1 as inhibitor of BCL-2, there are potential medicinal values and clinical values to develop crystalline or amorphous forms with possible medical values of the compound or their salts and solvates, to improve the stability, solubility, bioavailability and other properties of the compounds. 
     SUMMARY OF THE INVENTION 
     The present invention provides crystalline forms or amorphous forms of N-(phenyl sulfonyl) benzoamide compounds or their salts and solvates used as BCl-2 inhibitors, as well as preparation methods and applications thereof. The crystalline forms or amorphous forms of the invention are of great values for drug development, preparation development and production. 
     In the following descriptions, certain specific details are described to provide thorough understandings of the various embodiments of the invention. However, the persons skilled in the art will understand that the invention can be practiced without the details. The following descriptions of several embodiments are done with the understanding that the present disclosure is regarded as an example of the subject matter for which protection is sought, and is not intended to limit the attached claims to the particular embodiments shown. The headings used throughout the invention are provided for convenience only and shall not be construed as limiting claims in any way. The embodiments shown under any heading may be combined with the embodiments shown under any other heading. 
     In addition, when referring to, for example, XRPD patterns, DSC curves, TGA plots, etc., the terms “substantially as shown” mean that they are not necessarily the same as those described herein, but when considered by ordinary persons skilled in the art, the spectrum falls within the limits of experimental error or deviation. 
     In the first aspect, the present invention provides the amorphous or crystalline forms of the compound 1 below or its salts or solvates thereof: 
     
       
         
         
             
             
         
       
     
     The chemical name of the compound is (S)—N-((4-(((1,4-dioxan-2-yl) methyl) amino)-3-nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)piperazin-1-yl)benzamide. 
     Specifically, the form may be the following specific forms: 
     1) The Crystalline Form I of Compound 1 
     In one embodiment, the form is the crystalline form I of the compound 1, which is characterized by having at least three, at least four, at least five, at least six or seven characteristic peaks at the following positions in the X-ray powder diffraction (XRPD) pattern represented by angle 2θ: 7.57±0.2°, 16.41±0.2°, 17.76±0.2°, 18.44±0.2°, 19.39±0.2°, 20.34±0.2° and 21.08±0.2°. 
     In some preferred embodiments, the form also has one or more characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 4.39±0.2°, 11.23±0.2°, 14.59±0.2°, 15.17±0.2°, 15.87±0.2°, 21.69±0.2°, and 27.65±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 1 below and/or an X-ray powder diffraction (XRPD) pattern substantially as shown in FIG. 1. 
     
       
         
           
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.398789 
                 20.08838 
                 30.77 
               
               
                 7.578719 
                 11.66521 
                 100.00 
               
               
                 11.238130 
                 7.87361 
                 27.91 
               
               
                 13.137090 
                 6.73945 
                 16.03 
               
               
                 14.596170 
                 6.06887 
                 38.83 
               
               
                 15.172880 
                 5.83947 
                 43.81 
               
               
                 15.878410 
                 5.58155 
                 47.72 
               
               
                 16.418210 
                 5.39924 
                 86.91 
               
               
                 17.760590 
                 4.99407 
                 60.85 
               
               
                 18.445950 
                 4.81003 
                 65.18 
               
               
                 19.396030 
                 4.57651 
                 51.88 
               
               
                 20.347790 
                 4.36455 
                 62.66 
               
               
                 21.085680 
                 4.21345 
                 51.26 
               
               
                 21.692670 
                 4.09690 
                 48.84 
               
               
                 22.778780 
                 3.90396 
                 15.22 
               
               
                 24.749620 
                 3.59737 
                 10.92 
               
               
                 25.395710 
                 3.50729 
                 19.00 
               
               
                 25.964140 
                 3.43178 
                 18.56 
               
               
                 27.651780 
                 3.22605 
                 38.42 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the thermogravimetric analysis (TGA) plot, there is a weight loss of 2.4±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are three endothermic peaks at the peak temperature of 81.6±2.0° C. and the initial temperature of 148.9±2.0° C. and 179.9±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  2   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  3   . 
     2) The Crystalline Form II of Compound 1 
     In one embodiment, the form is the crystalline form II of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 7.22±0.2°, 14.48±0.2°, 18.73±0.2°, 19.08±0.2° and 20.50±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 2 below and/or an XRPD pattern substantially as shown in  FIG.  4   . 
     
       
         
           
               
               
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.222398 
                 14.20454 
                 17.57 
               
               
                 7.229177 
                 12.22843 
                 100.00 
               
               
                 7.971669 
                 11.09105 
                 12.06 
               
               
                 11.349910 
                 7.79632 
                 16.18 
               
               
                 12.762840 
                 6.93621 
                 2.43 
               
               
                 13.259160 
                 6.67767 
                 6.11 
               
               
                 13.697400 
                 6.46499 
                 13.28 
               
               
                 14.488100 
                 6.11389 
                 30.52 
               
               
                 15.677430 
                 5.65265 
                 5.73 
               
               
                 16.022260 
                 5.53177 
                 7.51 
               
               
                 17.179410 
                 5.16168 
                 5.80 
               
               
                 17.879770 
                 4.96105 
                 14.52 
               
               
                 18.737960 
                 4.73572 
                 23.56 
               
               
                 19.087960 
                 4.64967 
                 28.67 
               
               
                 19.933120 
                 4.45439 
                 8.99 
               
               
                 20.504600 
                 4.33152 
                 22.48 
               
               
                 21.079760 
                 4.21462 
                 10.79 
               
               
                 21.999300 
                 4.04049 
                 12.95 
               
               
                 23.071660 
                 3.85506 
                 3.88 
               
               
                 23.477170 
                 3.78938 
                 4.85 
               
               
                 24.142830 
                 3.68639 
                 6.42 
               
               
                 25.724490 
                 3.46321 
                 5.77 
               
               
                 26.138000 
                 3.40935 
                 6.54 
               
               
                 27.692480 
                 3.22140 
                 3.24 
               
               
                 29.250890 
                 3.05323 
                 1.80 
               
               
                 33.365200 
                 2.68554 
                 1.46 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 3.5±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are four endothermic peaks at the peak temperatures of 68.9±2.0° C. and 140.3±2.0° C., and the initial temperatures of 148.6±2.0° C. and 181.8±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  5   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  6   . 
     3) The Crystalline Form III of Compound 1 
     In one embodiment, the form is the crystalline form III of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.97±0.2°, 18.01±0.2°, 21.57±0.2°, 24.56±0.2° and 28.59±0.2°. 
     In some preferred embodiments, the form also has one or more characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 13.28±0.2°, 16.30±0.2°, 16.67±0.2°, 17.61±0.2°, 18.59±0.2°, 18.91±0.2°, 19.67±0.2° and 20.86±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 3 below and/or an XRPD pattern substantially as shown in  FIG.  7   . 
     
       
         
           
               
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.975145 
                 14.79176 
                 47.52 
               
               
                 6.717507 
                 13.15867 
                 9.24 
               
               
                 8.190475 
                 10.79524 
                 5.00 
               
               
                 9.408436 
                 9.40031 
                 17.14 
               
               
                 9.796705 
                 9.02861 
                 7.09 
               
               
                 12.438820 
                 7.11616 
                 19.19 
               
               
                 13.288440 
                 6.66302 
                 34.01 
               
               
                 13.475320 
                 6.57104 
                 17.29 
               
               
                 15.800150 
                 5.60903 
                 13.09 
               
               
                 16.304870 
                 5.43651 
                 34.15 
               
               
                 16.675740 
                 5.31643 
                 27.97 
               
               
                 17.619110 
                 5.03385 
                 34.95 
               
               
                 18.018940 
                 4.92304 
                 41.87 
               
               
                 18.590560 
                 4.77294 
                 27.20 
               
               
                 18.914260 
                 4.69198 
                 31.06 
               
               
                 19.670020 
                 4.51338 
                 21.59 
               
               
                 20.032360 
                 4.43255 
                 11.67 
               
               
                 20.274080 
                 4.38025 
                 16.97 
               
               
                 20.865780 
                 4.25735 
                 29.78 
               
               
                 21.575430 
                 4.11890 
                 100.00 
               
               
                 22.252120 
                 3.99515 
                 10.58 
               
               
                 22.750500 
                 3.90875 
                 8.91 
               
               
                 23.106110 
                 3.84939 
                 7.10 
               
               
                 24.081160 
                 3.69569 
                 9.51 
               
               
                 24.561610 
                 3.62448 
                 67.94 
               
               
                 25.214900 
                 3.53203 
                 17.60 
               
               
                 25.925200 
                 3.43685 
                 3.65 
               
               
                 26.898120 
                 3.31471 
                 3.21 
               
               
                 28.022590 
                 3.18420 
                 3.65 
               
               
                 28.595660 
                 3.12168 
                 35.57 
               
               
                 29.692590 
                 3.00881 
                 5.12 
               
               
                 30.419620 
                 2.93853 
                 2.65 
               
               
                 33.853320 
                 2.64793 
                 0.95 
               
               
                 34.955410 
                 2.56693 
                 3.59 
               
               
                 37.904080 
                 2.37375 
                 1.69 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 1.0±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperatures of 169.9±2.0° C. and 232.0±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  8   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  9   . 
     4) the 1, 4-Dioxane Solvate Crystalline Form IV of Compound 1 
     In one embodiment, the form is the 1, 4-dioxane solvate crystalline form IV of the compound 1, which is characterized by having at least three, at least four, at least five or six characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 4.31±0.2°, 18.31±0.2°, 19.52±0.2°, 19.71±0.2°, 21.15±0.2° and 21.78±0.2°. 
     In some preferred embodiments, the form also has one or more characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 8.50±0.2°, 15.95±0.2°, 16.54±0.2°, 17.45±0.2° and 20.42±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 4 below and/or an XRPD pattern substantially as shown in  FIG.  10   . 
     
       
         
           
               
               
               
             
               
                 TABLE 4 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.312485 
                 20.49021 
                 78.81 
               
               
                 8.508758 
                 10.39213 
                 40.46 
               
               
                 13.923320 
                 6.36059 
                 21.12 
               
               
                 15.950660 
                 5.55644 
                 40.41 
               
               
                 16.540260 
                 5.35967 
                 47.83 
               
               
                 17.451310 
                 5.08187 
                 45.73 
               
               
                 18.319830 
                 4.84286 
                 100.00 
               
               
                 19.529070 
                 4.54563 
                 87.47 
               
               
                 19.711060 
                 4.50407 
                 88.13 
               
               
                 20.425160 
                 4.34819 
                 52.14 
               
               
                 21.153840 
                 4.20002 
                 85.74 
               
               
                 21.787240 
                 4.07933 
                 73.67 
               
               
                 22.910060 
                 3.88188 
                 21.49 
               
               
                 24.367900 
                 3.65285 
                 12.53 
               
               
                 25.922770 
                 3.43717 
                 24.88 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 12.8±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperatures of 120.6±2.0° C. and 206.2±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  11   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  12   . 
     5) The Ethyl Acetate Solvate Crystalline Form V of Compound 1 
     In one embodiment, the form is the ethyl acetate solvate crystalline form V of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 7.17±0.2°, 13.75±0.2°, 18.40±0.2°, 18.69±0.2° and 19.96±0.2°. 
     In some preferred embodiments, the form also has one or more characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 7.64±0.2°, 14.34±0.2° and 15.78±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 5 below and/or an XRPD pattern substantially as shown in  FIG.  13   . 
     
       
         
           
               
               
               
             
               
                 TABLE 5 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 7.172810 
                 12.32440 
                 100.00 
               
               
                 7.641418 
                 11.56963 
                 21.10 
               
               
                 11.335770 
                 7.80601 
                 12.96 
               
               
                 12.074100 
                 7.33028 
                 1.42 
               
               
                 13.757680 
                 6.43680 
                 29.91 
               
               
                 14.343160 
                 6.17535 
                 20.82 
               
               
                 15.315150 
                 5.78554 
                 16.33 
               
               
                 15.780080 
                 5.61611 
                 21.88 
               
               
                 17.872990 
                 4.96291 
                 13.40 
               
               
                 18.406510 
                 4.82025 
                 27.90 
               
               
                 18.699270 
                 4.74543 
                 34.32 
               
               
                 19.465670 
                 4.56029 
                 18.96 
               
               
                 19.969240 
                 4.44642 
                 25.78 
               
               
                 20.732010 
                 4.28452 
                 10.54 
               
               
                 21.553970 
                 4.12295 
                 12.88 
               
               
                 21.826540 
                 4.07208 
                 11.77 
               
               
                 23.280790 
                 3.82090 
                 12.00 
               
               
                 24.033230 
                 3.70295 
                 2.74 
               
               
                 24.892100 
                 3.57710 
                 5.27 
               
               
                 25.379920 
                 3.50944 
                 12.18 
               
               
                 28.958110 
                 3.08343 
                 9.76 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 1.88±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are three endothermic peaks at the peak temperatures of 103.8±2.0° C. and the initial temperatures of 141.9±2.0° C. and 182.6±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  14   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  15   . 
     6) The Methylbenzene Solvate Crystalline Form VI of Compound 1 
     In one embodiment, the form is the methylbenzene solvate crystalline form VI of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 7.16±0.2°, 18.02±0.2°, 18.76±0.2°, 19.97±0.2° and 20.64±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 6 below and/or an XRPD pattern substantially as shown in  FIG.  16   . 
     
       
         
           
               
               
               
             
               
                 TABLE 6 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 7.164968 
                 12.33787 
                 100.00 
               
               
                 7.642807 
                 11.56753 
                 17.15 
               
               
                 11.238760 
                 7.87317 
                 9.75 
               
               
                 14.277000 
                 6.20381 
                 14.82 
               
               
                 15.329030 
                 5.78033 
                 14.07 
               
               
                 15.697340 
                 5.64553 
                 11.79 
               
               
                 18.021390 
                 4.92238 
                 26.26 
               
               
                 18.769620 
                 4.72781 
                 32.94 
               
               
                 19.973060 
                 4.44558 
                 34.67 
               
               
                 20.642610 
                 4.30287 
                 18.73 
               
               
                 21.526950 
                 4.12806 
                 13.57 
               
               
                 25.393740 
                 3.50756 
                 10.64 
               
               
                 28.886500 
                 3.09091 
                 5.57 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 3.7±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperatures of 140.9±2.0° C. and 181.3±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  17   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  18   . 
     7) The Methylbenzene Solvate Crystalline Form VII of Compound 1 
     In one embodiment, the form is the methylbenzene solvate crystalline form VII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.80±0.2°, 17.81±0.2°, 18.59±0.2°, 20.10±0.2° and 21.65±0.2°. 
     In some preferred embodiments, the form also has one or more characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 7.52±0.2°, 16.48±0.2°, 20.60±0.2° and 22.67±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 7 below and/or an XRPD pattern substantially as shown in  FIG.  19   . 
     
       
         
           
               
               
               
             
               
                 TABLE 7 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.803095 
                 15.22991 
                 100.00 
               
               
                 7.529270 
                 11.74171 
                 29.89 
               
               
                 10.426180 
                 8.48488 
                 17.97 
               
               
                 11.601380 
                 7.62789 
                 13.02 
               
               
                 14.268860 
                 6.20733 
                 23.10 
               
               
                 15.214400 
                 5.82363 
                 19.97 
               
               
                 16.489410 
                 5.37609 
                 25.00 
               
               
                 16.889090 
                 5.24975 
                 15.83 
               
               
                 17.815320 
                 4.97885 
                 34.09 
               
               
                 18.599270 
                 4.77072 
                 55.32 
               
               
                 19.701340 
                 4.50627 
                 21.50 
               
               
                 20.108540 
                 4.41593 
                 36.04 
               
               
                 20.601230 
                 4.31142 
                 29.11 
               
               
                 20.925900 
                 4.24526 
                 22.23 
               
               
                 21.653950 
                 4.10414 
                 39.86 
               
               
                 22.672100 
                 3.92208 
                 25.61 
               
               
                 23.583180 
                 3.77259 
                 18.94 
               
               
                 24.384570 
                 3.65039 
                 16.07 
               
               
                 25.132610 
                 3.54341 
                 23.91 
               
               
                 27.619650 
                 3.22973 
                 10.74 
               
               
                 29.565150 
                 3.02148 
                 3.93 
               
               
                 30.415650 
                 2.93891 
                 6.78 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 10.0±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperatures of 64.6±2.0° C. and 134.8±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  20   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  21   . 
     8) The Chloroform Solvate Crystalline Form VIII of Compound 1 
     In one embodiment, the form is the chloroform solvate crystalline form VIII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.37±0.2°, 19.83±0.2°, 21.15±0.2°, 21.49±0.2° and 22.93±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 8 below and/or an XRPD pattern substantially as shown in  FIG.  22   . 
     
       
         
           
               
               
               
             
               
                 TABLE 8 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.379363 
                 16.42859 
                 100.00 
               
               
                 7.654765 
                 11.54949 
                 7.24 
               
               
                 15.995650 
                 5.54091 
                 14.41 
               
               
                 16.895780 
                 5.24769 
                 19.16 
               
               
                 19.835830 
                 4.47602 
                 51.31 
               
               
                 21.158350 
                 4.19914 
                 31.56 
               
               
                 21.492740 
                 4.13456 
                 47.81 
               
               
                 22.930980 
                 3.87839 
                 35.17 
               
               
                 24.981970 
                 3.56443 
                 21.26 
               
               
                 26.943120 
                 3.30927 
                 11.33 
               
               
                 28.064460 
                 3.17955 
                 13.03 
               
               
                 30.290330 
                 2.95078 
                 6.88 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 2.7±0.2% by weight before 70° C., a weight loss of 11.0±0.2% by weight between 70° C. and 150° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 138.2±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  23   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  24   . 
     9) The Methyl Tert-Butyl Ether Solvate Crystalline Form IX of Compound 1 
     In one embodiment, the form is the methyl tert-butyl ether solvate crystalline form IX of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.92±0.2°, 7.42±0.2°, 13.11±0.2°, 15.87±0.2° and 18.95±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 9 below and/or an XRPD pattern substantially as shown in  FIG.  25   . 
     
       
         
           
               
               
               
             
               
                 TABLE 9 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.921207 
                 14.92638 
                 56.46 
               
               
                 7.422888 
                 11.90974 
                 100.00 
               
               
                 13.117090 
                 6.74967 
                 20.56 
               
               
                 15.876100 
                 5.58236 
                 27.04 
               
               
                 18.957900 
                 4.68127 
                 38.94 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 10.6±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are three endothermic peaks at the peak temperatures of 50.5±2.0° C. and 136.0±2.0° C., and the initial temperature of 180.9±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  26   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  27   . 
     10) The 2-Methyltetrahydrofuran Solvate Crystalline Form X of Compound 1 
     In one embodiment, the form is the 2-methyltetrahydrofuran solvate crystalline form X of the compound 1, which is characterized by having at least three, at least four, at least five or six characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.85±0.2°, 7.42±0.2°, 16.64±0.2°, 18.88±0.2°, 19.68±0.2° and 22.37±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 10 below and/or an XRPD pattern substantially as shown in  FIG.  28   . 
     
       
         
           
               
               
               
             
               
                 TABLE 10 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.854990 
                 15.09504 
                 74.88 
               
               
                 7.422709 
                 11.91003 
                 27.25 
               
               
                 11.958840 
                 7.40067 
                 9.24 
               
               
                 13.126820 
                 6.74470 
                 10.51 
               
               
                 14.352660 
                 6.17128 
                 13.92 
               
               
                 15.159070 
                 5.84476 
                 14.54 
               
               
                 16.647690 
                 5.32533 
                 100.00 
               
               
                 17.521520 
                 5.06166 
                 18.13 
               
               
                 18.888170 
                 4.69840 
                 58.85 
               
               
                 19.686100 
                 4.50973 
                 33.61 
               
               
                 21.591600 
                 4.11585 
                 16.49 
               
               
                 22.374300 
                 3.97361 
                 30.48 
               
               
                 28.953770 
                 3.08388 
                 6.73 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 10.7±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperatures of 111.1±2.0° C. and 217.4±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  29   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  30   . 
     11) The Crystalline Form XI of Compound 1 
     In one embodiment, the form is the crystalline form XI of the compound 1, which is characterized by having at least three, at least four, at least five or six characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.48±0.2°, 13.58±0.2°, 15.65±0.2°, 20.72±0.2°, 21.79±0.2° and 22.40±0.2°. 
     In some preferred embodiments, the form also has one or more characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 14.42±0.2°, 18.72±0.2°, 19.07±0.2°, 23.64±0.2° and 26.20±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 11 below and/or an XRPD pattern substantially as shown in  FIG.  31   . 
     
       
         
           
               
               
               
             
               
                 TABLE 11 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.484990 
                 16.11245 
                 95.80 
               
               
                 7.062830 
                 12.51606 
                 28.21 
               
               
                 9.208320 
                 9.60414 
                 24.77 
               
               
                 10.861810 
                 8.14554 
                 21.79 
               
               
                 12.421030 
                 7.12631 
                 31.96 
               
               
                 13.589810 
                 6.51593 
                 100.00 
               
               
                 14.423790 
                 6.14101 
                 43.94 
               
               
                 15.651250 
                 5.66205 
                 68.01 
               
               
                 16.475610 
                 5.38056 
                 35.91 
               
               
                 17.295420 
                 5.12732 
                 37.55 
               
               
                 18.729450 
                 4.73786 
                 58.96 
               
               
                 19.070380 
                 4.65392 
                 50.29 
               
               
                 20.336380 
                 4.36697 
                 28.22 
               
               
                 20.720330 
                 4.28691 
                 74.73 
               
               
                 21.287200 
                 4.17401 
                 39.82 
               
               
                 21.796110 
                 4.07769 
                 81.98 
               
               
                 22.400240 
                 3.96907 
                 74.98 
               
               
                 23.093490 
                 3.85146 
                 17.18 
               
               
                 23.642120 
                 3.76331 
                 40.34 
               
               
                 25.370340 
                 3.51074 
                 17.65 
               
               
                 25.697150 
                 3.46683 
                 26.83 
               
               
                 26.204600 
                 3.40084 
                 51.20 
               
               
                 28.470660 
                 3.13510 
                 11.23 
               
               
                 30.785420 
                 2.90445 
                 14.02 
               
               
                 31.469770 
                 2.84283 
                 11.83 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 2.5±0.2% by weight before 150° C.; 
     2) In the DSC curve, there is an endothermic peaks at the initial temperature of 145.9±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  32   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  33   . 
     12) The Acetone Solvate Crystalline Form XII of Compound 1 
     In one embodiment, the form is the acetone solvate crystalline form XII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.42±0.2°, 13.62±0.20° 15.64±0.2°, 21.62±0.2° and 22.19±0.2°. 
     In some preferred embodiments, the form also has one or more characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 18.50±0.2°, 19.08±0.2° and 20.51±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 12 below and/or an XRPD pattern substantially as shown in  FIG.  34   . 
     
       
         
           
               
               
               
             
               
                 TABLE 12 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.427239 
                 16.28377 
                 100.00 
               
               
                 7.035403 
                 12.56480 
                 15.62 
               
               
                 9.591051 
                 9.22173 
                 8.09 
               
               
                 10.766550 
                 8.21740 
                 8.17 
               
               
                 12.324840 
                 7.18171 
                 21.10 
               
               
                 13.628900 
                 6.49733 
                 98.45 
               
               
                 14.414280 
                 6.14504 
                 25.42 
               
               
                 15.649520 
                 5.66267 
                 63.12 
               
               
                 16.334140 
                 5.42684 
                 23.32 
               
               
                 17.057810 
                 5.19821 
                 7.53 
               
               
                 18.085580 
                 4.90505 
                 12.55 
               
               
                 18.502160 
                 4.79554 
                 43.18 
               
               
                 19.083620 
                 4.65072 
                 43.82 
               
               
                 20.519820 
                 4.32834 
                 35.71 
               
               
                 21.629670 
                 4.10869 
                 55.92 
               
               
                 22.197940 
                 4.00478 
                 50.10 
               
               
                 23.495830 
                 3.78641 
                 22.34 
               
               
                 25.117810 
                 3.54546 
                 12.00 
               
               
                 25.961090 
                 3.43218 
                 24.72 
               
               
                 30.208900 
                 2.95855 
                 4.13 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 1.0±0.2% by weight before 90° C., a weight loss of 3.6±0.2% by weight between 90° C. and 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the peak temperature of 59.1±2.0° C., and the initial temperature of 146.2±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  35   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  36   . 
     13) The Crystalline Form XIII of Compound 1 
     In one embodiment, the form is the crystalline form XIII of the compound 1, which is characterized by having characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 6.24±0.2°, 8.15±0.2° and 18.06±0.2°. 
     In some preferred embodiments, the form also has one or more characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 12.49±0.2°, 16.78±0.2°, 19.47±0.2 and 22.11±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 13 below and/or an XRPD pattern substantially as shown in  FIG.  37   . 
     
       
         
           
               
               
               
             
               
                 TABLE 13 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.243906 
                 14.15566 
                 100.00 
               
               
                 8.151101 
                 10.84730 
                 43.46 
               
               
                 12.495670 
                 7.08391 
                 13.26 
               
               
                 13.756630 
                 6.43729 
                 9.10 
               
               
                 16.787310 
                 5.28135 
                 15.24 
               
               
                 18.063500 
                 4.91100 
                 38.05 
               
               
                 19.472620 
                 4.55868 
                 16.40 
               
               
                 20.725150 
                 4.28592 
                 8.76 
               
               
                 22.111080 
                 4.02031 
                 17.52 
               
               
                 24.029790 
                 3.70347 
                 4.06 
               
               
                 27.171430 
                 3.28198 
                 4.31 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 2.6±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the peak temperature of 87.0±2.0° C., and the initial temperature of 142.8±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  38   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  39   . 
     14) The Crystalline Form XIV of Compound 1 
     In one embodiment, the form is the crystalline form XIV of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.13±0.2°, 10.56±0.2°, 16.08±0.2°, 18.17±0.2° and 20.77±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 14 below and/or an XRPD pattern substantially as shown in  FIG.  40   . 
     
       
         
           
               
               
               
             
               
                 TABLE 14 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.134706 
                 17.21081 
                 100.00 
               
               
                 10.560930 
                 8.37692 
                 23.64 
               
               
                 16.080350 
                 5.51191 
                 33.44 
               
               
                 18.173090 
                 4.88163 
                 17.73 
               
               
                 20.775140 
                 4.27572 
                 25.29 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 8.4±0.2% by weight before 150° C.; 
     2) In the DSC curve, there is an endothermic peaks at the initial temperature of 127.8±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  41   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  42   . 
     15) The Crystalline Form XV of Compound 1 
     In one embodiment, the form is the crystalline form XV of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 4.53±0.2°, 6.17±0.2°, 9.90±0.2°, 16.71±0.2° and 17.83±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 15 below and/or an XRPD pattern substantially as shown in  FIG.  43   . 
     
       
         
           
               
               
               
             
               
                 TABLE 15 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.533975 
                 19.48973 
                 100.00 
               
               
                 6.171669 
                 14.32118 
                 41.94 
               
               
                 7.324262 
                 12.06989 
                 8.87 
               
               
                 9.908910 
                 8.92662 
                 20.00 
               
               
                 15.469880 
                 5.72802 
                 11.95 
               
               
                 16.717670 
                 5.30319 
                 19.12 
               
               
                 17.833560 
                 4.97380 
                 41.68 
               
               
                 19.729100 
                 4.49999 
                 13.54 
               
               
                 21.674970 
                 4.10021 
                 12.35 
               
               
                 22.913390 
                 3.88133 
                 10.66 
               
               
                 25.223830 
                 3.53080 
                 4.51 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 1.6±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are three endothermic peaks at the peak temperature of 71.2±2.0° C., and the initial temperatures of 134.1±2.0° C. and 151.6±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  44   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  45   . 
     16) The N,N-Dimethylformamide Solvate Crystalline Form XVI of Compound 1 
     In one embodiment, the form is the N,N-dimethylformamide solvate crystalline form XVI of the compound 1, which is characterized by having at least three, at least four, at least five or six characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 6.13±0.2°, 6.97±0.2°, 13.84±0.2°, 18.35±0.2°, 19.00±0.2° and 19.55±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 16 below and/or an XRPD pattern substantially as shown in  FIG.  46   . 
     
       
         
           
               
               
               
             
               
                 TABLE 16 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.136095 
                 14.40413 
                 61.33 
               
               
                 6.974022 
                 12.67525 
                 75.93 
               
               
                 9.308429 
                 9.50108 
                 14.18 
               
               
                 11.538670 
                 7.66920 
                 22.55 
               
               
                 13.840300 
                 6.39856 
                 71.19 
               
               
                 14.585040 
                 6.07347 
                 39.01 
               
               
                 17.021680 
                 5.20916 
                 20.82 
               
               
                 18.351910 
                 4.83446 
                 58.82 
               
               
                 19.003900 
                 4.67005 
                 100.00 
               
               
                 19.552870 
                 4.54015 
                 53.22 
               
               
                 22.508360 
                 3.95024 
                 15.78 
               
               
                 29.090570 
                 3.06969 
                 15.86 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 5.2±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperatures of 79.9±2.0° C. and 137.6±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  47   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  48   . 
     17) The Crystalline Form XVII of Compound 1 
     In one embodiment, the form is the crystalline form XVII of the compound 1, which is characterized by having at least three, at least four, at least five or six characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 4.50±0.2°, 7.33±0.2°, 15.20±0.2°, 17.55±0.2°, 18.06±0.2° and 19.49±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 17 below and/or an XRPD pattern substantially as shown in  FIG.  49   . 
     
       
         
           
               
               
               
             
               
                 TABLE 17 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.503521 
                 19.62145 
                 100.00 
               
               
                 7.332149 
                 12.05693 
                 3.18 
               
               
                 15.205640 
                 5.82696 
                 3.99 
               
               
                 17.553090 
                 5.05263 
                 11.43 
               
               
                 18.066850 
                 4.91010 
                 25.07 
               
               
                 19.496320 
                 4.55319 
                 4.68 
               
               
                 23.484990 
                 3.78814 
                 2.67 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 1.4±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the peak temperature of 54.2±2.0° C., and at the initial temperature of 152.8±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  50   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  51   . 
     18) The Crystalline Form XVIII of Compound 1 
     In one embodiment, the form is the crystalline form XVIII of the compound 1, which is characterized by having at least three, at least four, at least five or six characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.93±0.2°, 8.61±0.2°, 17.28±0.2°, 20.60±0.2°, 21.45±0.2° and 21.76±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 18 below and/or an XRPD pattern substantially as shown in  FIG.  52   . 
     
       
         
           
               
               
               
             
               
                 TABLE 18 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.933129 
                 14.89642 
                 100.00 
               
               
                 8.614887 
                 10.26434 
                 24.28 
               
               
                 13.205550 
                 6.70466 
                 11.46 
               
               
                 15.472060 
                 5.72722 
                 13.01 
               
               
                 15.900780 
                 5.57375 
                 10.00 
               
               
                 17.285050 
                 5.13038 
                 24.52 
               
               
                 19.085030 
                 4.65038 
                 18.86 
               
               
                 19.934790 
                 4.45402 
                 7.05 
               
               
                 20.605150 
                 4.31061 
                 21.19 
               
               
                 21.457360 
                 4.14129 
                 23.19 
               
               
                 21.760920 
                 4.08421 
                 26.20 
               
               
                 23.304920 
                 3.81700 
                 5.11 
               
               
                 25.214420 
                 3.53210 
                 5.22 
               
               
                 26.444540 
                 3.37052 
                 7.27 
               
               
                 27.284040 
                 3.26869 
                 7.04 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.3±0.2% by weight before 150° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 206.7±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  53   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  54   . 
     19) The Hydrochloride Crystalline Form XIX of Compound 1 
     In one embodiment, the form is the hydrochloride crystalline form XIX of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 9.53±0.2°, 16.70±0.20° 20.56±0.2°, 21.23±0.2° and 23.79±0.2°. 
     In some preferred embodiments, the form also has one or more characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 11.07±0.2°, 15.44±0.2°, 19.78±0.2° and 28.81±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 19 below and/or an XRPD pattern substantially as shown in  FIG.  55   . 
     
       
         
           
               
               
               
             
               
                 TABLE 19 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 9.539562 
                 9.27139 
                 100.00 
               
               
                 11.075690 
                 7.98872 
                 33.00 
               
               
                 12.564500 
                 7.04525 
                 18.68 
               
               
                 15.440520 
                 5.73885 
                 45.22 
               
               
                 16.708640 
                 5.30604 
                 92.75 
               
               
                 19.540860 
                 4.54292 
                 12.89 
               
               
                 19.781710 
                 4.48814 
                 52.96 
               
               
                 20.569680 
                 4.31796 
                 61.79 
               
               
                 21.230820 
                 4.18497 
                 70.60 
               
               
                 22.153050 
                 4.01279 
                 27.10 
               
               
                 22.721560 
                 3.91366 
                 25.15 
               
               
                 23.793660 
                 3.73969 
                 60.64 
               
               
                 24.863470 
                 3.58115 
                 23.72 
               
               
                 26.604090 
                 3.35067 
                 10.95 
               
               
                 28.818910 
                 3.09800 
                 35.30 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 2.3±0.2% by weight before 150° C., and a weight loss of 4.4±0.2% by weight between 150° C. and 200° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 189.5±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  56   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  57   . 
     20) The Sulphate Crystalline Form XX of Compound 1 
     In one embodiment, the form is the sulphate crystalline form XX of the compound 1, which is characterized by having characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 15.62±0.2°, 19.69±0.2° and 23.33±0.2°. 
     In some preferred embodiments, the form also has one or more characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 8.34±0.2°, 16.56±0.2°, 18.12±0.2° and 26.64±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 20 below and/or an XRPD pattern substantially as shown in  FIG.  58   . 
     
       
         
           
               
               
               
             
               
                 TABLE 20 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 7.585601 
                 11.65464 
                 19.74 
               
               
                 8.340707 
                 10.60113 
                 38.62 
               
               
                 9.747928 
                 9.07367 
                 19.81 
               
               
                 13.496060 
                 6.56098 
                 15.26 
               
               
                 15.620950 
                 5.67296 
                 51.20 
               
               
                 16.566680 
                 5.35119 
                 43.32 
               
               
                 18.128790 
                 4.89346 
                 38.04 
               
               
                 19.697750 
                 4.50709 
                 100.00 
               
               
                 20.760740 
                 4.27865 
                 23.25 
               
               
                 23.336240 
                 3.81194 
                 53.41 
               
               
                 24.729300 
                 3.60028 
                 17.45 
               
               
                 26.640530 
                 3.34617 
                 44.27 
               
               
                 27.280030 
                 3.26916 
                 21.13 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 6.0±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperature of 89.2±2.0° C. and 176.1±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  59   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  60   . 
     21) The Mesylate Crystalline Form XXI of Compound 1 
     In one embodiment, the form is the mesylate crystalline form XXI of the compound 1, which is characterized by having characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 4.63±0.2°, 9.80±0.2° and 16.06±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 21 below and/or an XRPD pattern substantially as shown in  FIG.  61   . 
     
       
         
           
               
               
               
             
               
                 TABLE 21 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.638124 
                 19.05231 
                 29.06 
               
               
                 9.803409 
                 9.02245 
                 100.00 
               
               
                 16.066760 
                 5.51654 
                 31.60 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 4.2±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the peak temperature of 86.4±2.0° C., and at the initial temperature of 168.4±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  62   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  63   . 
     22) The Mesylate Crystalline Form XXII of Compound 1 
     In one embodiment, the form is the mesylate crystalline form XXII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 6.15±0.2°, 7.80±0.2°, 14.56±0.2°, 17.28±0.2° and 18.48±0.2°. 
     In some preferred embodiments, the form also has one or more characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 21.83±0.2° and 24.61±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 22 below and/or an XRPD pattern substantially as shown in  FIG.  64   . 
     
       
         
           
               
               
               
             
               
                 TABLE 22 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.152556 
                 14.36563 
                 100.00 
               
               
                 7.806105 
                 11.32591 
                 48.55 
               
               
                 8.861501 
                 9.97923 
                 25.22 
               
               
                 11.152830 
                 7.93364 
                 11.64 
               
               
                 12.325510 
                 7.18132 
                 26.89 
               
               
                 14.563390 
                 6.08245 
                 45.89 
               
               
                 17.282420 
                 5.13115 
                 53.33 
               
               
                 18.482060 
                 4.80071 
                 66.00 
               
               
                 19.802230 
                 4.48354 
                 24.55 
               
               
                 21.830550 
                 4.07134 
                 35.39 
               
               
                 22.721290 
                 3.91370 
                 18.42 
               
               
                 24.617090 
                 3.61643 
                 34.16 
               
               
                 29.276030 
                 3.05066 
                 7.43 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 2.6±0.2% by weight before 150° C.; 
     2) In the DSC curve, there are two endothermic peaks at the peak temperature of 102.6±2.0° C., and at the initial temperature of 181.3±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  65   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  66   . 
     23) The Maleate Crystalline Form XXIII of Compound 1 
     In one embodiment, the form is the maleate crystalline form XXIII of the compound 1, which is characterized by having at least three, at least four, at least five or six characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.32±0.2°, 8.73±0.2°, 13.02±0.2°, 18.94±0.2°, 22.85±0.2° and 25.20±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 23 below and/or an XRPD pattern substantially as shown in  FIG.  67   . 
     
       
         
           
               
               
               
             
               
                 TABLE 23 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.329199 
                 16.58312 
                 47.67 
               
               
                 8.734749 
                 10.12376 
                 80.53 
               
               
                 10.681700 
                 8.28247 
                 22.28 
               
               
                 13.024280 
                 6.79756 
                 53.14 
               
               
                 14.909210 
                 5.94214 
                 22.54 
               
               
                 15.484520 
                 5.72264 
                 21.90 
               
               
                 16.017330 
                 5.53346 
                 27.30 
               
               
                 17.075090 
                 5.19298 
                 16.48 
               
               
                 18.948690 
                 4.68353 
                 100.00 
               
               
                 19.738370 
                 4.49790 
                 29.28 
               
               
                 21.420210 
                 4.14839 
                 6.51 
               
               
                 22.858420 
                 3.89054 
                 44.54 
               
               
                 25.208590 
                 3.53290 
                 60.84 
               
               
                 26.260470 
                 3.39373 
                 24.04 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 3.2±0.2% by weight before 150° C., and a weight loss of 8.6±0.2% by weight between 150° C. and 220° C.; 
     2) In the DSC curve, there are two endothermic peaks at the peak temperature of 90.2±2.0° C. and at the initial temperature of 174.8±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  68   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  69   . 
     24) The Maleate Crystalline Form XXIV of Compound 1 
     In one embodiment, the form is the maleate crystalline form XXIV of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 4.77±0.2°, 12.50±0.20° 15.33±0.2°, 18.73±0.2° and 22.28±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 24 below and/or an XRPD pattern substantially as shown in  FIG.  70   . 
     
       
         
           
               
               
               
             
               
                 TABLE 24 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.774768 
                 18.50738 
                 100.00 
               
               
                 7.619892 
                 11.60227 
                 8.51 
               
               
                 8.129279 
                 10.87637 
                 8.70 
               
               
                 9.512488 
                 9.29772 
                 16.46 
               
               
                 11.797940 
                 7.50124 
                 11.89 
               
               
                 12.500530 
                 7.08117 
                 19.98 
               
               
                 14.342810 
                 6.17550 
                 8.70 
               
               
                 14.815180 
                 5.97964 
                 6.52 
               
               
                 15.336490 
                 5.77754 
                 38.49 
               
               
                 15.899480 
                 5.57421 
                 6.37 
               
               
                 16.421160 
                 5.39828 
                 6.67 
               
               
                 17.826810 
                 4.97566 
                 14.35 
               
               
                 18.734350 
                 4.73663 
                 54.62 
               
               
                 20.725170 
                 4.28592 
                 10.47 
               
               
                 21.380980 
                 4.15592 
                 12.16 
               
               
                 22.286330 
                 3.98909 
                 21.48 
               
               
                 22.976860 
                 3.87075 
                 16.21 
               
               
                 24.604320 
                 3.61828 
                 16.37 
               
               
                 26.930830 
                 3.31076 
                 10.38 
               
               
                 29.843420 
                 2.99394 
                 4.68 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 1.7±0.2% by weight before 150° C., and a weight loss of 9.1±0.2% by weight between 150° C. and 220° C.; 
     2) In the DSC curve, there are two endothermic peaks at the peak temperature of 70.5±2.0° C. and at the initial temperature of 190.0±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  71   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  72   . 
     25) The Amorphous Form XXV of Compound 1 
     In one embodiment, the form is the amorphous form XXV of the compound 1, 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 3.0±0.2% by weight before 150° C.; 
     2) In the DSC curve, there is a glassy transition temperature at the midpoint temperature of 121.5±2.0° C.; 
     3) the XRPD pattern substantially as shown in  FIG.  73   ; 
     4) the TGA plot substantially as shown in  FIG.  74   ; and/or 
     5) the DSC curve substantially as shown in  FIG.  75   . 
     26) The Acetone Solvate Crystalline Form XXVI of Compound 1 
     In one embodiment, the form is the acetone solvate crystalline form XXVI of the compound 1, which is characterized by having at least three, at least four, at least five or six characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 6.12±0.2°, 8.07±0.2°, 16.79±0.2°, 17.90±0.2°, 19.09±0.2° and 22.39±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 25 below and/or an XRPD pattern substantially as shown in  FIG.  76   . 
     
       
         
           
               
               
               
             
               
                 TABLE 25 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.129 
                 14.4079 
                 100 
               
               
                 8.073 
                 10.9432 
                 51.3 
               
               
                 8.422 
                 10.4904 
                 14.3 
               
               
                 11.178 
                 7.9093 
                 10.7 
               
               
                 12.212 
                 7.2418 
                 23.5 
               
               
                 13.105 
                 6.7502 
                 19.4 
               
               
                 15.707 
                 5.6373 
                 19.8 
               
               
                 16.799 
                 5.2732 
                 39.3 
               
               
                 17.908 
                 4.9492 
                 61.8 
               
               
                 18.295 
                 4.8453 
                 19.0 
               
               
                 18.685 
                 4.7449 
                 16.6 
               
               
                 19.09 
                 4.6451 
                 42.4 
               
               
                 19.696 
                 4.5037 
                 23.8 
               
               
                 20.393 
                 4.3512 
                 27.9 
               
               
                 20.80 
                 4.267 
                 21.4 
               
               
                 21.635 
                 4.1043 
                 11.90 
               
               
                 22.396 
                 3.9664 
                 61.0 
               
               
                 23.387 
                 3.8006 
                 23.20 
               
               
                 24.325 
                 3.6561 
                 10.0 
               
               
                 24.942 
                 3.567 
                 11.80 
               
               
                 25.252 
                 3.5239 
                 17.0 
               
               
                 29.682 
                 3.0072 
                 16.1 
               
               
                   
               
            
           
         
       
     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.18±0.02% by weight before 74.2° C., and a weight loss of 5.0±0.2% by weight between 74.2° C. and 168.55° C.; 
     2) In the DSC curve, there is an endothermic peaks at the peak temperature of 152.3±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  77   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  78   . 
     27) The Benzene Sulfonate Crystalline Form XXVII of Compound 1 
     In one embodiment, the form is the benzene sulfonate crystalline Form XXVII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 10.03±0.2°, 17.22±0.2°, 17.68±0.2°, 18.79±0.2°, 20.43±0.2°, 21.69±0.2°, 24.83±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 26 below and/or an XRPD pattern substantially as shown in  FIG.  79   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 2.4±0.2% by weight before 190.8° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 250.2±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  80   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  81   . 
     
       
         
           
               
               
               
             
               
                 TABLE 26 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.8 
                 12.9889 
                 27 
               
               
                 9.021 
                 9.7945 
                 19.1 
               
               
                 10.032 
                 8.81 
                 98.9 
               
               
                 11.02 
                 8.0221 
                 7.9 
               
               
                 12.019 
                 7.3574 
                 31.7 
               
               
                 12.503 
                 7.0739 
                 14.6 
               
               
                 13.44 
                 6.5826 
                 47.3 
               
               
                 14.043 
                 6.3012 
                 44.8 
               
               
                 15.817 
                 5.5982 
                 16.7 
               
               
                 16.421 
                 5.3938 
                 36.6 
               
               
                 17.22 
                 5.1452 
                 59.8 
               
               
                 17.686 
                 5.0106 
                 97.6 
               
               
                 18.799 
                 4.7164 
                 63.9 
               
               
                 20.434 
                 4.3425 
                 75.2 
               
               
                 21.699 
                 4.0922 
                 100 
               
               
                 22.812 
                 3.895 
                 22.5 
               
               
                 23.492 
                 3.7838 
                 43.4 
               
               
                 24.838 
                 3.5817 
                 72.3 
               
               
                 25.326 
                 3.5138 
                 42.3 
               
               
                 25.848 
                 3.444 
                 23.5 
               
               
                 26.978 
                 3.3022 
                 14.4 
               
               
                 27.446 
                 3.247 
                 12.9 
               
               
                 28.399 
                 3.1402 
                 14.6 
               
               
                 29.278 
                 3.0479 
                 38.1 
               
               
                 30.466 
                 2.9316 
                 19.9 
               
               
                 32.005 
                 2.7941 
                 11.9 
               
               
                   
               
            
           
         
       
     
     28) The p-Toluenesulfonate Crystalline Form XXVIII of Compound 1 
     In one embodiment, the form is the p-toluenesulfonate crystalline Form XXVIII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 6.66±0.2°, 9.25±0.2°, 9.48±0.2°, 10.18±0.2°, 13.53±0.2°, 14.14±0.2°, 17.06±0.2°, 18.03±0.2°, 18.44±0.2°, 19.24±0.2°, 19.79±0.2°, 20.35±0.2°, 21.83±0.2°, 24.95±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 27 below and/or an XRPD pattern substantially as shown in  FIG.  82   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 2.4±0.2% by weight before 113.0° C.; and a weight loss of 1.8±0.2% by weight between 113.0-200.7° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 165.2±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  83   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  84   . 
     
       
         
           
               
               
               
             
               
                 TABLE 27 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.337 
                 13.9366 
                 26.1 
               
               
                 6.662 
                 13.2559 
                 63.2 
               
               
                 8.181 
                 10.798 
                 38.5 
               
               
                 8.727 
                 10.1245 
                 32.2 
               
               
                 9.252 
                 9.5504 
                 96.5 
               
               
                 9.485 
                 9.3164 
                 58.5 
               
               
                 10.188 
                 8.6756 
                 51 
               
               
                 11.493 
                 7.6928 
                 9.6 
               
               
                 12.524 
                 7.062 
                 35.7 
               
               
                 13.538 
                 6.5352 
                 77.4 
               
               
                 14.143 
                 6.2568 
                 74.1 
               
               
                 15.818 
                 5.5979 
                 38.2 
               
               
                 17.062 
                 5.1925 
                 78.1 
               
               
                 17.24 
                 5.1392 
                 39.6 
               
               
                 18.038 
                 4.9137 
                 77.2 
               
               
                 18.447 
                 4.8057 
                 100 
               
               
                 19.244 
                 4.6083 
                 86.2 
               
               
                 19.791 
                 4.4822 
                 73.4 
               
               
                 20.356 
                 4.3591 
                 68.5 
               
               
                 20.872 
                 4.2525 
                 9.1 
               
               
                 21.837 
                 4.0667 
                 83.9 
               
               
                 24.953 
                 3.5655 
                 51.7 
               
               
                 29.162 
                 3.0597 
                 33.1 
               
               
                   
               
            
           
         
       
     
     29) The p-Toluenesulfonate Crystalline Form XXIX of Compound 1 
     In one embodiment, the form is the p-toluenesulfonate crystalline Form XXIX of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 9.99±0.2°, 17.21±0.2°, 19.38±0.2°, 19.85±0.2°, 22.57±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 28 below and/or an XRPD pattern substantially as shown in  FIG.  85   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.12±0.02% by weight before 236.4° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 222.7±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  86   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  87   . 
     
       
         
           
               
               
               
             
               
                 TABLE 28 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.701 
                 13.1804 
                 22.8 
               
               
                 7.051 
                 12.5256 
                 16.1 
               
               
                 7.577 
                 11.6582 
                 13.8 
               
               
                 8.59 
                 10.2853 
                 17.3 
               
               
                 9.718 
                 9.0938 
                 12.6 
               
               
                 9.993 
                 8.8446 
                 70.9 
               
               
                 10.677 
                 8.2792 
                 6.2 
               
               
                 11.391 
                 7.7614 
                 14.2 
               
               
                 12.876 
                 6.8696 
                 9.3 
               
               
                 13.244 
                 6.6794 
                 10 
               
               
                 13.85 
                 6.3885 
                 6.6 
               
               
                 15.017 
                 5.8947 
                 25.1 
               
               
                 15.253 
                 5.804 
                 8.4 
               
               
                 15.543 
                 5.6965 
                 38.9 
               
               
                 15.973 
                 5.5441 
                 8.1 
               
               
                 17.217 
                 5.146 
                 98.9 
               
               
                 17.627 
                 5.0272 
                 9.9 
               
               
                 18.253 
                 4.8562 
                 14.4 
               
               
                 18.544 
                 4.7807 
                 40.1 
               
               
                 18.743 
                 4.7305 
                 14.1 
               
               
                 19.03 
                 4.6598 
                 39.1 
               
               
                 19.381 
                 4.5762 
                 100 
               
               
                 19.852 
                 4.4685 
                 47.6 
               
               
                 20.433 
                 4.3428 
                 23.7 
               
               
                 20.882 
                 4.2505 
                 13.6 
               
               
                 21.291 
                 4.1696 
                 25.8 
               
               
                 21.72 
                 4.0884 
                 22.9 
               
               
                 22.108 
                 4.0175 
                 20.2 
               
               
                 22.578 
                 3.9349 
                 65.1 
               
               
                 23.492 
                 3.7837 
                 15.3 
               
               
                 24.058 
                 3.6961 
                 30.6 
               
               
                 24.271 
                 3.6641 
                 12.1 
               
               
                 24.836 
                 3.582 
                 15.7 
               
               
                 25.013 
                 3.5571 
                 6.3 
               
               
                 25.305 
                 3.5167 
                 18.1 
               
               
                 25.89 
                 3.4385 
                 12.7 
               
               
                 27.25 
                 3.2699 
                 17.2 
               
               
                 27.661 
                 3.2222 
                 7.1 
               
               
                 28.227 
                 3.1589 
                 10.1 
               
               
                 28.537 
                 3.1253 
                 19 
               
               
                 28.987 
                 3.0778 
                 10.3 
               
               
                 29.493 
                 3.0261 
                 14.5 
               
               
                 29.785 
                 2.9971 
                 7.1 
               
               
                 30.113 
                 2.9653 
                 12.3 
               
               
                 30.642 
                 2.9152 
                 8 
               
               
                 31.967 
                 2.7974 
                 7.3 
               
               
                 32.844 
                 2.7246 
                 2.3 
               
               
                 33.463 
                 2.6756 
                 5.7 
               
               
                 33.644 
                 2.6617 
                 3.1 
               
               
                 33.977 
                 2.6363 
                 2.1 
               
               
                 35.139 
                 2.5518 
                 2.4 
               
               
                 35.842 
                 2.5033 
                 7 
               
               
                 37.321 
                 2.4074 
                 2.7 
               
               
                   
               
            
           
         
       
     
     30) The Sulphate Crystalline Form XXX of Compound 1 
     In one embodiment, the form is the sulphate crystalline Form XXX of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 8.22±0.2°, 15.38±0.2°, 17.68±0.2°, 18.48±0.2°, 19.07±0.2°, 21.03±0.2°, 21.92±0.2°, 24.8±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 29 below and/or an XRPD pattern substantially as shown in  FIG.  88   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.13±0.02% by weight before 81.9° C.; a weight loss of 5.8±0.2% by weight between 81.9° C.-204.3° C.; and a weight loss of 4.0±0.2% by weight between 204.3° C.-242.7° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperature of 134.5±2.0° C. and 212.3±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  89   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  90   . 
     
       
         
           
               
               
               
             
               
                 TABLE 29 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.809 
                 18.3592 
                 5.2 
               
               
                 7.6 
                 11.6232 
                 8.8 
               
               
                 8.22 
                 10.7474 
                 29.2 
               
               
                 9.629 
                 9.1774 
                 12.1 
               
               
                 10.121 
                 8.733 
                 3.7 
               
               
                 10.31 
                 8.5727 
                 2.9 
               
               
                 11.947 
                 7.4014 
                 8.9 
               
               
                 12.62 
                 7.0087 
                 17.1 
               
               
                 13.9 
                 6.3657 
                 3 
               
               
                 14.36 
                 6.1628 
                 17 
               
               
                 15.38 
                 5.7563 
                 26.6 
               
               
                 16.259 
                 5.4471 
                 9.4 
               
               
                 16.51 
                 5.3647 
                 1.9 
               
               
                 17.18 
                 5.157 
                 14.2 
               
               
                 17.68 
                 5.0124 
                 84.3 
               
               
                 18.481 
                 4.7969 
                 27.5 
               
               
                 19.07 
                 4.6501 
                 100 
               
               
                 19.46 
                 4.5578 
                 5.8 
               
               
                 19.98 
                 4.4402 
                 4.1 
               
               
                 20.329 
                 4.3647 
                 6.9 
               
               
                 20.72 
                 4.2833 
                 10.2 
               
               
                 21.03 
                 4.2209 
                 32.3 
               
               
                 21.92 
                 4.0515 
                 42.8 
               
               
                 22.27 
                 3.9885 
                 5.1 
               
               
                 22.88 
                 3.8836 
                 21.7 
               
               
                 23.141 
                 3.8404 
                 4.4 
               
               
                 23.42 
                 3.7952 
                 8 
               
               
                 23.71 
                 3.7496 
                 9 
               
               
                 23.959 
                 3.7111 
                 4.1 
               
               
                 24.8 
                 3.5871 
                 59.8 
               
               
                 25.259 
                 3.5229 
                 11.3 
               
               
                 25.672 
                 3.4672 
                 1.9 
               
               
                 26.1 
                 3.4113 
                 22.5 
               
               
                 26.64 
                 3.3434 
                 14.2 
               
               
                 27.43 
                 3.2489 
                 6.2 
               
               
                 27.73 
                 3.2144 
                 1.4 
               
               
                 28.1 
                 3.1729 
                 2.1 
               
               
                 28.89 
                 3.0879 
                 1.7 
               
               
                 29.5 
                 3.0254 
                 3.8 
               
               
                 29.939 
                 2.982 
                 2 
               
               
                 30.349 
                 2.9427 
                 1.6 
               
               
                 30.708 
                 2.9091 
                 2.1 
               
               
                 31.658 
                 2.8239 
                 2.2 
               
               
                 32.6 
                 2.7445 
                 6.6 
               
               
                 32.9 
                 2.7201 
                 3.2 
               
               
                 33.62 
                 2.6635 
                 4.3 
               
               
                 34.709 
                 2.5824 
                 2.1 
               
               
                 35.08 
                 2.5559 
                 4.5 
               
               
                 35.459 
                 2.5294 
                 1.9 
               
               
                 36.34 
                 2.4701 
                 2.5 
               
               
                 36.871 
                 2.4358 
                 2.1 
               
               
                 38.761 
                 2.3212 
                 2.2 
               
               
                   
               
            
           
         
       
     
     31) The Sulphate Crystalline Form XXXI of Compound 1 
     In one embodiment, the form is the sulphate crystalline Form XXXI of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 4.28±0.2°, 8.45±0.2°, 10.20±0.2°, 17.94±0.2°, 18.21±0.2°, 18.89±0.2°, 19.07±0.2°, 20.45±0.2°, 20.82±0.2°, 21.27±0.2°, 22.20±0.2°, 24.79±0.2°, 26.35±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 30 below and/or an XRPD pattern substantially as shown in  FIG.  91   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.05±0.02% by weight before 195.4° C.; and a weight loss of 1.1±0.2% by weight between 195.4° C.-219.2° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 192.7±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  92   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  93   . 
     
       
         
           
               
               
               
             
               
                 TABLE 30 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.284 
                 20.61 
                 49.9 
               
               
                 7.17 
                 12.3192 
                 18.4 
               
               
                 8.453 
                 10.4515 
                 49.3 
               
               
                 9.763 
                 9.0523 
                 33.1 
               
               
                 10.209 
                 8.6579 
                 59.2 
               
               
                 11.335 
                 7.8001 
                 26.7 
               
               
                 12.196 
                 7.2512 
                 28.5 
               
               
                 12.584 
                 7.0286 
                 21.6 
               
               
                 13.461 
                 6.5725 
                 34.7 
               
               
                 14.239 
                 6.2151 
                 27.7 
               
               
                 15.372 
                 5.7593 
                 13.3 
               
               
                 15.992 
                 5.5373 
                 26.7 
               
               
                 16.795 
                 5.2746 
                 30.4 
               
               
                 16.989 
                 5.2146 
                 38.1 
               
               
                 17.942 
                 4.9397 
                 48.8 
               
               
                 18.216 
                 4.8661 
                 100 
               
               
                 18.892 
                 4.6934 
                 65.1 
               
               
                 19.071 
                 4.6498 
                 62.4 
               
               
                 19.597 
                 4.5261 
                 28 
               
               
                 20.456 
                 4.3381 
                 53.3 
               
               
                 20.822 
                 4.2625 
                 57.9 
               
               
                 21.276 
                 4.1726 
                 46.9 
               
               
                 22.206 
                 3.9999 
                 66.9 
               
               
                 22.77 
                 3.9022 
                 27.7 
               
               
                 23.608 
                 3.7654 
                 37.9 
               
               
                 23.786 
                 3.7377 
                 31.7 
               
               
                 24.798 
                 3.5874 
                 53.6 
               
               
                 25.599 
                 3.477 
                 14.9 
               
               
                 26.354 
                 3.379 
                 59.2 
               
               
                 26.958 
                 3.3046 
                 28 
               
               
                 28.343 
                 3.1463 
                 12 
               
               
                 28.912 
                 3.0856 
                 10.1 
               
               
                 29.414 
                 3.0341 
                 20.3 
               
               
                 30.214 
                 2.9556 
                 14.7 
               
               
                 30.704 
                 2.9094 
                 12.3 
               
               
                 32.356 
                 2.7646 
                 20.5 
               
               
                   
               
            
           
         
       
     
     32) The Sulphate Crystalline Form XXXII of Compound 1 
     In one embodiment, the form is the sulphate crystalline Form XXXII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 4.28±0.2°, 16.71±0.2°, 16.92±0.2°, 20.82±0.2°, 21.32±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 31 below and/or an XRPD pattern substantially as shown in  FIG.  94   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 1.6±0.2% by weight before 162.0° C.; and a weight loss of 1.4±0.2% by weight between 162.0° C.-223.5° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 181.2±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  95   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  96   . 
     
       
         
           
               
               
               
             
               
                 TABLE 31 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.286 
                 20.6007 
                 100 
               
               
                 6.076 
                 14.5342 
                 3.3 
               
               
                 6.587 
                 13.4081 
                 6.8 
               
               
                 6.802 
                 12.9834 
                 6.3 
               
               
                 7.09 
                 12.4578 
                 4.4 
               
               
                 7.867 
                 11.2284 
                 3.6 
               
               
                 8.417 
                 10.496 
                 4.1 
               
               
                 9.152 
                 9.6551 
                 5.2 
               
               
                 10.034 
                 8.8077 
                 7 
               
               
                 15.876 
                 5.5778 
                 4.6 
               
               
                 16.714 
                 5.2999 
                 21.4 
               
               
                 16.926 
                 5.2338 
                 23.4 
               
               
                 18.117 
                 4.8924 
                 13.3 
               
               
                 18.543 
                 4.7811 
                 10.8 
               
               
                 19.065 
                 4.6512 
                 6 
               
               
                 20.048 
                 4.4253 
                 6.2 
               
               
                 20.826 
                 4.2618 
                 20.6 
               
               
                 21.329 
                 4.1625 
                 19.9 
               
               
                 23.102 
                 3.8469 
                 5.1 
               
               
                 23.883 
                 3.7227 
                 12.8 
               
               
                 24.472 
                 3.6344 
                 5.5 
               
               
                 28.087 
                 3.1744 
                 8.4 
               
               
                   
               
            
           
         
       
     
     33) The Mesylate Crystalline Form XXXIII of Compound 1 
     In one embodiment, the form is the mesylate crystalline Form XXXIII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 7.93±0.2°, 15.28±0.2°, 17.57±0.2°, 18.78±0.2°, 21.86±0.2°, 22.89±0.2°, 24.86±0.2°, 26.00±0.2θ. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 32 below and/or an XRPD pattern substantially as shown in  FIG.  97   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.5±0.2% by weight before 69.0° C.; and a weight loss of 5.6±0.2% by weight between 69.0° C.-216.2° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 190.6±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  98   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  99   . 
     
       
         
           
               
               
               
             
               
                 TABLE 32 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.871 
                 18.1276 
                 22.2 
               
               
                 7.6 
                 11.622 
                 8.6 
               
               
                 7.93 
                 11.1399 
                 38.9 
               
               
                 9.5 
                 9.302 
                 14.2 
               
               
                 9.74 
                 9.0729 
                 11.2 
               
               
                 10.237 
                 8.634 
                 4.5 
               
               
                 10.35 
                 8.5396 
                 4.1 
               
               
                 11.73 
                 7.5378 
                 14.7 
               
               
                 12.66 
                 6.9865 
                 15.7 
               
               
                 14.24 
                 6.2144 
                 9 
               
               
                 14.52 
                 6.0953 
                 10.4 
               
               
                 15.289 
                 5.7903 
                 60.7 
               
               
                 15.79 
                 5.6079 
                 18.4 
               
               
                 16.69 
                 5.3073 
                 5.6 
               
               
                 17.19 
                 5.1542 
                 25 
               
               
                 17.36 
                 5.1042 
                 15.3 
               
               
                 17.579 
                 5.0408 
                 65.9 
               
               
                 18.32 
                 4.8387 
                 17.5 
               
               
                 18.78 
                 4.7213 
                 100 
               
               
                 19.079 
                 4.6478 
                 6.3 
               
               
                 19.449 
                 4.5603 
                 8.6 
               
               
                 19.9 
                 4.458 
                 5.6 
               
               
                 20.5 
                 4.3288 
                 14 
               
               
                 20.79 
                 4.269 
                 13.9 
               
               
                 21.14 
                 4.1991 
                 20.9 
               
               
                 21.481 
                 4.1332 
                 3.4 
               
               
                 21.86 
                 4.0624 
                 39.8 
               
               
                 22.89 
                 3.8819 
                 34.3 
               
               
                 23.1 
                 3.8471 
                 8.7 
               
               
                 23.281 
                 3.8177 
                 7.4 
               
               
                 23.621 
                 3.7635 
                 10.2 
               
               
                 24.28 
                 3.6627 
                 15.1 
               
               
                 24.52 
                 3.6275 
                 16.5 
               
               
                 24.86 
                 3.5786 
                 42.9 
               
               
                 25.2 
                 3.5311 
                 2.7 
               
               
                 25.72 
                 3.4609 
                 6.8 
               
               
                 26.009 
                 3.423 
                 31.1 
               
               
                 26.34 
                 3.3808 
                 4.7 
               
               
                 26.668 
                 3.3399 
                 2.5 
               
               
                 27.19 
                 3.2769 
                 1.6 
               
               
                 27.61 
                 3.2281 
                 12 
               
               
                 27.9 
                 3.1952 
                 4.6 
               
               
                 28.08 
                 3.1751 
                 4.2 
               
               
                 28.59 
                 3.1196 
                 3.7 
               
               
                 29.85 
                 2.9908 
                 4 
               
               
                 30.451 
                 2.9331 
                 2.2 
               
               
                 30.94 
                 2.8879 
                 4.3 
               
               
                 31.65 
                 2.8247 
                 4.8 
               
               
                 32.229 
                 2.7752 
                 2.7 
               
               
                 32.561 
                 2.7477 
                 2.2 
               
               
                 32.949 
                 2.7161 
                 3.4 
               
               
                 33.533 
                 2.6702 
                 1.7 
               
               
                 34.242 
                 2.6165 
                 1.3 
               
               
                 34.69 
                 2.5837 
                 2.2 
               
               
                 35.07 
                 2.5566 
                 3.4 
               
               
                 35.387 
                 2.5344 
                 1.3 
               
               
                 35.919 
                 2.4981 
                 1.7 
               
               
                 36.79 
                 2.4409 
                 2.2 
               
               
                 37.4 
                 2.4026 
                 1.4 
               
               
                 37.81 
                 2.3774 
                 1.7 
               
               
                 38.14 
                 2.3576 
                 2.6 
               
               
                 38.8 
                 2.319 
                 2.9 
               
               
                   
               
            
           
         
       
     
     34) The Mesylate Crystalline Form XXXIV of Compound 1 
     In one embodiment, the form is the mesylate crystalline Form XXXIV of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 10.57±0.2°, 13.48±0.2°, 14.65±0.2°, 16.30±0.2°, 16.92±0.2°, 18.23±0.2°, 19.89±0.2°, 21.89±0.2°, 22.16±0.2°, 24.70±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 33 below and/or an XRPD pattern substantially as shown in  FIG.  100   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.2±0.1% by weight before 224.2° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 207.1±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  101   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  102   . 
     
       
         
           
               
               
               
             
               
                 TABLE 33 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.802 
                 12.9852 
                 23.2 
               
               
                 9.176 
                 9.6302 
                 4.4 
               
               
                 10.578 
                 8.3567 
                 99.1 
               
               
                 11.394 
                 7.7593 
                 20.1 
               
               
                 12.604 
                 7.0175 
                 37.5 
               
               
                 13.481 
                 6.5628 
                 42.4 
               
               
                 13.892 
                 6.3695 
                 27.8 
               
               
                 14.65 
                 6.0417 
                 54.4 
               
               
                 16.305 
                 5.4318 
                 50.1 
               
               
                 16.927 
                 5.2338 
                 43 
               
               
                 17.241 
                 5.1389 
                 13.8 
               
               
                 17.688 
                 5.0102 
                 11.6 
               
               
                 17.924 
                 4.9446 
                 22.9 
               
               
                 18.233 
                 4.8615 
                 100 
               
               
                 19.285 
                 4.5986 
                 16.3 
               
               
                 19.694 
                 4.5042 
                 18.1 
               
               
                 19.89 
                 4.4602 
                 44.7 
               
               
                 20.412 
                 4.3472 
                 21.8 
               
               
                 20.958 
                 4.2352 
                 20.3 
               
               
                 21.136 
                 4.2 
                 14.2 
               
               
                 21.525 
                 4.1249 
                 13.4 
               
               
                 21.893 
                 4.0563 
                 89.2 
               
               
                 22.169 
                 4.0065 
                 61.1 
               
               
                 22.712 
                 3.912 
                 29 
               
               
                 22.967 
                 3.8691 
                 15.8 
               
               
                 23.745 
                 3.744 
                 6 
               
               
                 24.041 
                 3.6986 
                 5.6 
               
               
                 24.701 
                 3.6012 
                 39.2 
               
               
                 25.224 
                 3.5277 
                 7.1 
               
               
                 25.538 
                 3.4851 
                 0.7 
               
               
                 26.007 
                 3.4234 
                 5.1 
               
               
                 26.22 
                 3.396 
                 9.1 
               
               
                 26.706 
                 3.3353 
                 13 
               
               
                 27.388 
                 3.2538 
                 9.9 
               
               
                 27.756 
                 3.2114 
                 6.7 
               
               
                 27.934 
                 3.1914 
                 13 
               
               
                 28.205 
                 3.1613 
                 11.5 
               
               
                 28.667 
                 3.1114 
                 4.5 
               
               
                 28.945 
                 3.0822 
                 28.8 
               
               
                 29.511 
                 3.0243 
                 7.8 
               
               
                 30.56 
                 2.9229 
                 6.7 
               
               
                 31.03 
                 2.8797 
                 3.3 
               
               
                 31.714 
                 2.8191 
                 4.4 
               
               
                 32.161 
                 2.7809 
                 5.6 
               
               
                 32.547 
                 2.7488 
                 12.5 
               
               
                 33.199 
                 2.6963 
                 6.1 
               
               
                 34.074 
                 2.629 
                 3.4 
               
               
                 35.364 
                 2.536 
                 4.8 
               
               
                 36.217 
                 2.4782 
                 3.2 
               
               
                 36.68 
                 2.448 
                 5.6 
               
               
                 37.888 
                 2.3727 
                 5.4 
               
               
                 38.181 
                 2.3551 
                 5.2 
               
               
                 39.763 
                 2.265 
                 3.4 
               
               
                   
               
            
           
         
       
     
     35) The Mesylate Crystalline Form XXXV of Compound 1 
     In one embodiment, the form is the mesylate crystalline Form XXXV of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 9.54±0.2°, 16.47±0.2°, 16.69±0.2°, 16.94±0.2°, 18.71±0.2°, 19.71±0.2°, 20.33±0.2°, 20.98±0.2°, 21.75±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 34 below and/or an XRPD pattern substantially as shown in  FIG.  103   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 2.3±0.2% by weight before 85.2° C.; a weight loss of 3.4±0.2% by weight between 85.2° C.-131.5° C.; a weight loss of 2.7±0.2% by weight between 131.5° C.-188.8° C.; and a weight loss of 0.9±0.2% by weight between 188.8° C.-236.1° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperature of 169.5±2.0° C. and 234.0±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  104   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  105   . 
     
       
         
           
               
               
               
             
               
                 TABLE 34 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 8.999 
                 9.8191 
                 31.5 
               
               
                 9.545 
                 9.2585 
                 93.5 
               
               
                 9.9 
                 8.9267 
                 10.8 
               
               
                 10.169 
                 8.6916 
                 35 
               
               
                 11.317 
                 7.8124 
                 29.3 
               
               
                 12.798 
                 6.9114 
                 29.3 
               
               
                 13.362 
                 6.6209 
                 13.5 
               
               
                 14.104 
                 6.2741 
                 19.3 
               
               
                 14.571 
                 6.0743 
                 26.2 
               
               
                 15.447 
                 5.7317 
                 22.7 
               
               
                 16.479 
                 5.3749 
                 67.8 
               
               
                 16.694 
                 5.3062 
                 52 
               
               
                 16.949 
                 5.2269 
                 100 
               
               
                 17.613 
                 5.0313 
                 22.5 
               
               
                 17.936 
                 4.9415 
                 39.3 
               
               
                 18.719 
                 4.7365 
                 82.8 
               
               
                 19.716 
                 4.4992 
                 60.7 
               
               
                 20.336 
                 4.3634 
                 69.8 
               
               
                 20.98 
                 4.2309 
                 78.3 
               
               
                 21.47 
                 4.1354 
                 22.5 
               
               
                 21.759 
                 4.0811 
                 50 
               
               
                 23.554 
                 3.7739 
                 36.2 
               
               
                 24.016 
                 3.7024 
                 8.7 
               
               
                 24.68 
                 3.6043 
                 33.3 
               
               
                 25.948 
                 3.431 
                 32 
               
               
                 27.33 
                 3.2605 
                 23.5 
               
               
                 28.101 
                 3.1728 
                 7.5 
               
               
                 28.654 
                 3.1128 
                 34.3 
               
               
                 29.784 
                 2.9973 
                 16.5 
               
               
                   
               
            
           
         
       
     
     36) The Citrate Crystalline Form XXXVI of Compound 1 
     In one embodiment, the form is the citrate crystalline Form XXXVI of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 15.99±0.2°, 18.62±0.2°, 19.13±0.2°, 19.28±0.2°, 22.13±0.2°, 24.1±0.2°, 26.82±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 35 below and/or an XRPD pattern substantially as shown in  FIG.  106     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.4±0.2% by weight before 106.7° C.; and a weight loss of 19.4±0.2% by weight between 106.7° C.-231.8° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperature of 157.7±2.0° C. and 222.2±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  107   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  108   . 
     
       
         
           
               
               
               
             
               
                 TABLE 35 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.77 
                 18.5099 
                 23.8 
               
               
                 7.001 
                 12.6157 
                 12.2 
               
               
                 7.98 
                 11.0697 
                 32.3 
               
               
                 8.95 
                 9.8725 
                 33.9 
               
               
                 9.19 
                 9.6147 
                 2.1 
               
               
                 9.59 
                 9.215 
                 6.7 
               
               
                 10.619 
                 8.3239 
                 5.2 
               
               
                 11.139 
                 7.9368 
                 12.6 
               
               
                 12.281 
                 7.2013 
                 17 
               
               
                 12.53 
                 7.0586 
                 6.4 
               
               
                 13.85 
                 6.3889 
                 11 
               
               
                 14.12 
                 6.267 
                 19.9 
               
               
                 14.279 
                 6.1977 
                 7.2 
               
               
                 14.999 
                 5.9017 
                 13.8 
               
               
                 15.17 
                 5.8355 
                 12.3 
               
               
                 15.38 
                 5.7562 
                 26.3 
               
               
                 15.81 
                 5.6007 
                 13.5 
               
               
                 15.99 
                 5.538 
                 44.3 
               
               
                 16.24 
                 5.4536 
                 15.6 
               
               
                 16.59 
                 5.3391 
                 2.9 
               
               
                 16.739 
                 5.2918 
                 3 
               
               
                 17.5 
                 5.0635 
                 19.1 
               
               
                 18 
                 4.924 
                 24.9 
               
               
                 18.62 
                 4.7614 
                 37.3 
               
               
                 18.823 
                 4.7105 
                 5.2 
               
               
                 19.13 
                 4.6356 
                 100 
               
               
                 19.289 
                 4.5978 
                 41.3 
               
               
                 19.579 
                 4.5302 
                 18 
               
               
                 19.77 
                 4.487 
                 3 
               
               
                 20.161 
                 4.4009 
                 12.8 
               
               
                 20.561 
                 4.3162 
                 2 
               
               
                 21.13 
                 4.201 
                 31.9 
               
               
                 21.34 
                 4.1603 
                 22.7 
               
               
                 21.631 
                 4.105 
                 4.3 
               
               
                 21.8 
                 4.0735 
                 4.5 
               
               
                 22.13 
                 4.0136 
                 69.4 
               
               
                 22.965 
                 3.8694 
                 1.1 
               
               
                 23.25 
                 3.8226 
                 6.1 
               
               
                 23.619 
                 3.7637 
                 24.8 
               
               
                 24.1 
                 3.6897 
                 44.7 
               
               
                 24.729 
                 3.5972 
                 2.6 
               
               
                 25.121 
                 3.542 
                 2.2 
               
               
                 25.67 
                 3.4675 
                 15.2 
               
               
                 26.122 
                 3.4086 
                 1.1 
               
               
                 26.829 
                 3.3202 
                 43 
               
               
                 27.46 
                 3.2454 
                 7.9 
               
               
                 28.09 
                 3.174 
                 2.5 
               
               
                 28.35 
                 3.1455 
                 7 
               
               
                 28.88 
                 3.0889 
                 2.7 
               
               
                 29.37 
                 3.0385 
                 5 
               
               
                 29.94 
                 2.982 
                 9.7 
               
               
                 30.11 
                 2.9655 
                 16.2 
               
               
                 30.379 
                 2.9398 
                 3.2 
               
               
                 31.05 
                 2.8779 
                 4.3 
               
               
                 31.37 
                 2.8492 
                 2.2 
               
               
                 31.928 
                 2.8007 
                 2.4 
               
               
                 32.52 
                 2.751 
                 5.5 
               
               
                 32.97 
                 2.7145 
                 3.5 
               
               
                 33.481 
                 2.6742 
                 1.8 
               
               
                 33.829 
                 2.6475 
                 3.2 
               
               
                 34.119 
                 2.6257 
                 3.2 
               
               
                 34.849 
                 2.5723 
                 3 
               
               
                 35.262 
                 2.5432 
                 2.8 
               
               
                 36.459 
                 2.4623 
                 5.7 
               
               
                 37.209 
                 2.4144 
                 1.5 
               
               
                 37.848 
                 2.3751 
                 1.6 
               
               
                 38.2 
                 2.354 
                 2.5 
               
               
                 38.859 
                 2.3156 
                 3 
               
               
                 39.24 
                 2.294 
                 1.3 
               
               
                   
               
            
           
         
       
     
     37) The Citrate Crystalline Form XXXVII of Compound 1 
     In one embodiment, the form is the citrate crystalline Form XXXVII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.96±0.2°, 15.31±0.2°, 16.92±0.2°, 17.94±0.2°, 18.77±0.2°, 19.01±0.2°, 20.06±0.2°, 21.03±0.2°, 21.75±0.2°, 22.96±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 36 below and/or an XRPD pattern substantially as shown in  FIG.  109   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.9±0.2% by weight before 128.2° C.; and a weight loss of 8.3±0.2% by weight between 128.2° C.-232.40° C.; 
     2) In the DSC curve, there are three endothermic peaks at the initial temperature of 138.8±2.0° C., 179.5±2.0° C. and 229.3±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  110   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  111   . 
     
       
         
           
               
               
               
             
               
                 TABLE 36 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.377 
                 16.4223 
                 36.4 
               
               
                 5.96 
                 14.8155 
                 100 
               
               
                 7.656 
                 11.5375 
                 43.1 
               
               
                 8.277 
                 10.6731 
                 40.7 
               
               
                 9.564 
                 9.2396 
                 33.2 
               
               
                 10.538 
                 8.3883 
                 35.5 
               
               
                 11.669 
                 7.5774 
                 5.4 
               
               
                 12.428 
                 7.1163 
                 39.8 
               
               
                 13.536 
                 6.5361 
                 36.1 
               
               
                 14.357 
                 6.1642 
                 45.9 
               
               
                 15.312 
                 5.782 
                 51 
               
               
                 15.856 
                 5.5846 
                 25.5 
               
               
                 16.928 
                 5.2334 
                 63.6 
               
               
                 17.94 
                 4.9402 
                 79.1 
               
               
                 18.777 
                 4.7219 
                 90 
               
               
                 19.012 
                 4.6642 
                 61.3 
               
               
                 19.267 
                 4.6031 
                 21.3 
               
               
                 20.066 
                 4.4215 
                 87.8 
               
               
                 20.726 
                 4.2822 
                 27.1 
               
               
                 21.038 
                 4.2193 
                 60.1 
               
               
                 21.759 
                 4.081 
                 67.7 
               
               
                 22.344 
                 3.9756 
                 37.9 
               
               
                 22.965 
                 3.8694 
                 72 
               
               
                 23.766 
                 3.7409 
                 33.4 
               
               
                 24.505 
                 3.6296 
                 46.8 
               
               
                 24.739 
                 3.5959 
                 13.1 
               
               
                 25.343 
                 3.5115 
                 48.3 
               
               
                 26.045 
                 3.4184 
                 28.2 
               
               
                 27.795 
                 3.207 
                 6.7 
               
               
                 28.809 
                 3.0964 
                 29.1 
               
               
                 29.745 
                 3.001 
                 18 
               
               
                 30.548 
                 2.924 
                 12.1 
               
               
                 30.955 
                 2.8865 
                 9.8 
               
               
                 31.206 
                 2.8638 
                 22.7 
               
               
                 31.812 
                 2.8106 
                 17.6 
               
               
                 33.309 
                 2.6876 
                 17.7 
               
               
                   
               
            
           
         
       
     
     38) The Citrate Crystalline Form XXXVIII of Compound 1 
     In one embodiment, the form is the citrate crystalline Form XXXVIII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 7.79±0.2°, 9.54±0.2°, 9.87±0.2°, 17.61±0.2°, 17.80±0.2°, 22.48±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 37 below and/or an XRPD pattern substantially as shown in  FIG.  112   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 2.2±0.2% by weight before 142.1° C.; and a weight loss of 15.1±0.2% by weight between 142.1° C.-230.1° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperature of 135.3±2.0° C. and 160.9±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  113   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  114   . 
     
       
         
           
               
               
               
             
               
                 TABLE 37 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 3.994 
                 22.1028 
                 33.5 
               
               
                 7.308 
                 12.0861 
                 12.5 
               
               
                 7.791 
                 11.3374 
                 70.5 
               
               
                 9.077 
                 9.7343 
                 31.8 
               
               
                 9.545 
                 9.2582 
                 59.3 
               
               
                 9.876 
                 8.9486 
                 60.5 
               
               
                 10.206 
                 8.6598 
                 19.8 
               
               
                 11.473 
                 7.7062 
                 9.3 
               
               
                 11.805 
                 7.4905 
                 25.5 
               
               
                 13.304 
                 6.6498 
                 19.7 
               
               
                 13.769 
                 6.4259 
                 9.6 
               
               
                 14.142 
                 6.2572 
                 14.7 
               
               
                 14.512 
                 6.0986 
                 23 
               
               
                 15.696 
                 5.6411 
                 13.5 
               
               
                 16.19 
                 5.47 
                 17.8 
               
               
                 16.615 
                 5.3313 
                 16.5 
               
               
                 17.611 
                 5.0319 
                 81.4 
               
               
                 17.804 
                 4.9778 
                 100 
               
               
                 18.819 
                 4.7116 
                 46 
               
               
                 19.4 
                 4.5716 
                 35.1 
               
               
                 20.048 
                 4.4254 
                 29.2 
               
               
                 20.355 
                 4.3593 
                 27.2 
               
               
                 20.764 
                 4.2743 
                 11.2 
               
               
                 21.66 
                 4.0995 
                 47.2 
               
               
                 22.481 
                 3.9516 
                 56.4 
               
               
                 22.707 
                 3.9128 
                 42.9 
               
               
                 23.222 
                 3.8272 
                 10.1 
               
               
                 23.683 
                 3.7537 
                 4.9 
               
               
                 24.25 
                 3.6672 
                 22.1 
               
               
                 25.15 
                 3.538 
                 6 
               
               
                 25.674 
                 3.4669 
                 19.5 
               
               
                 26.239 
                 3.3935 
                 21.2 
               
               
                 26.651 
                 3.342 
                 11.3 
               
               
                 27.563 
                 3.2335 
                 8.6 
               
               
                 27.817 
                 3.2046 
                 9.7 
               
               
                 28.126 
                 3.17 
                 7.1 
               
               
                 28.59 
                 3.1197 
                 6.3 
               
               
                 28.949 
                 3.0817 
                 10.9 
               
               
                 29.533 
                 3.0221 
                 15.3 
               
               
                 29.94 
                 2.982 
                 32.8 
               
               
                 30.666 
                 2.913 
                 5.8 
               
               
                 31.052 
                 2.8776 
                 7.9 
               
               
                 32.574 
                 2.7466 
                 3.8 
               
               
                 33.429 
                 2.6783 
                 5.5 
               
               
                 33.801 
                 2.6497 
                 4.9 
               
               
                 36.375 
                 2.4679 
                 4.1 
               
               
                 37.885 
                 2.3728 
                 5.7 
               
               
                   
               
            
           
         
       
     
     39) The Citrate Crystalline Form XXXIX of Compound 1 
     In one embodiment, the form is the citrate crystalline Form XXXIX of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 8.49±0.2°, 12.81±0.2°, 13.85±0.2°, 16.30±0.2°, 17.08±0.2°, 17.89±0.2°, 18.68±0.2°, 19.84±0.2°, 21.62±0.2°, 22.98±0.2°, 25.20±0.2°, 26.61±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 38 below and/or an XRPD pattern substantially as shown in  FIG.  115   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.02±0.010% by weight before 124.6° C.; and a weight loss of 21.6±0.2% by weight between 124.6° C.-232.1° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 165.6±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  116   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  117   . 
     
       
         
           
               
               
               
             
               
                 TABLE 38 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.206 
                 16.9615 
                 6.1 
               
               
                 5.53 
                 15.9672 
                 16.4 
               
               
                 7.698 
                 11.4755 
                 41.2 
               
               
                 8.493 
                 10.4029 
                 55 
               
               
                 8.848 
                 9.9856 
                 32.1 
               
               
                 8.919 
                 9.9063 
                 33.9 
               
               
                 10.011 
                 8.8287 
                 21.9 
               
               
                 10.892 
                 8.1164 
                 21.9 
               
               
                 11.742 
                 7.5301 
                 15.4 
               
               
                 12.39 
                 7.1379 
                 12.8 
               
               
                 12.818 
                 6.9004 
                 52.8 
               
               
                 13.212 
                 6.6957 
                 21.3 
               
               
                 13.851 
                 6.3883 
                 49.7 
               
               
                 14.34 
                 6.1713 
                 9.8 
               
               
                 14.731 
                 6.0084 
                 15.2 
               
               
                 15.316 
                 5.7804 
                 8.3 
               
               
                 15.923 
                 5.5614 
                 7.6 
               
               
                 16.304 
                 5.4323 
                 50.7 
               
               
                 16.713 
                 5.3001 
                 33.9 
               
               
                 17.083 
                 5.1861 
                 50.1 
               
               
                 17.35 
                 5.107 
                 5.2 
               
               
                 17.899 
                 4.9515 
                 75.7 
               
               
                 18.177 
                 4.8763 
                 31 
               
               
                 18.682 
                 4.7457 
                 98.8 
               
               
                 18.992 
                 4.669 
                 41.5 
               
               
                 19.482 
                 4.5526 
                 10.8 
               
               
                 19.848 
                 4.4695 
                 100 
               
               
                 20.237 
                 4.3845 
                 37.4 
               
               
                 20.746 
                 4.2779 
                 20.8 
               
               
                 21.076 
                 4.2117 
                 38.2 
               
               
                 21.622 
                 4.1067 
                 78.2 
               
               
                 22.654 
                 3.9218 
                 22.2 
               
               
                 22.986 
                 3.866 
                 93.4 
               
               
                 23.237 
                 3.8248 
                 37 
               
               
                 23.488 
                 3.7844 
                 40.6 
               
               
                 23.684 
                 3.7535 
                 16.9 
               
               
                 24.333 
                 3.655 
                 32.8 
               
               
                 24.779 
                 3.5902 
                 19.4 
               
               
                 25.207 
                 3.5302 
                 62.1 
               
               
                 25.612 
                 3.4752 
                 14.3 
               
               
                 26.021 
                 3.4215 
                 7 
               
               
                 26.61 
                 3.3471 
                 58.8 
               
               
                 27.212 
                 3.2744 
                 11.1 
               
               
                 28.733 
                 3.1044 
                 20.1 
               
               
                 29.376 
                 3.038 
                 23.7 
               
               
                 30.016 
                 2.9746 
                 6.5 
               
               
                 30.278 
                 2.9495 
                 9.5 
               
               
                 30.76 
                 2.9043 
                 12.8 
               
               
                 31.338 
                 2.852 
                 8.6 
               
               
                 31.605 
                 2.8286 
                 6.8 
               
               
                 31.906 
                 2.8025 
                 16.3 
               
               
                 32.688 
                 2.7372 
                 8.6 
               
               
                 32.982 
                 2.7136 
                 11.9 
               
               
                 33.231 
                 2.6938 
                 8.3 
               
               
                 33.931 
                 2.6398 
                 10.8 
               
               
                 34.226 
                 2.6177 
                 9.9 
               
               
                 35.219 
                 2.5461 
                 7 
               
               
                 35.555 
                 2.5229 
                 8.3 
               
               
                 35.824 
                 2.5045 
                 9.2 
               
               
                 36.817 
                 2.4392 
                 5 
               
               
                 37.401 
                 2.4025 
                 7 
               
               
                 38.432 
                 2.3404 
                 8.6 
               
               
                   
               
            
           
         
       
     
     40) The Maleate Crystalline Form XL of Compound 1 
     In one embodiment, the form is the maleate crystalline Form XL of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.06±0.2°, 15.63±0.2°, 16.43±0.2°, 19.03±0.2°, 20.48±0.2°, 20.72±0.2°, 20.97±0.2°, 26.03±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 39 below and/or an XRPD pattern substantially as shown in  FIG.  118     
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.12±0.02% by weight before 81.6° C.; and a weight loss of 15.6±0.2% by weight between 81.6° C.-224.8° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperature of 154.5±2.0° C. and 220.3±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  119   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  120   . 
     
       
         
           
               
               
               
             
               
                 TABLE 39 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.06 
                 17.4513 
                 100 
               
               
                 8.44 
                 10.4678 
                 2.3 
               
               
                 8.821 
                 10.0164 
                 3.6 
               
               
                 9.529 
                 9.2736 
                 4.5 
               
               
                 10.07 
                 8.7769 
                 8.3 
               
               
                 10.76 
                 8.2154 
                 6 
               
               
                 11.469 
                 7.709 
                 7 
               
               
                 11.581 
                 7.6348 
                 5 
               
               
                 12.459 
                 7.0985 
                 5 
               
               
                 14.18 
                 6.2407 
                 4.3 
               
               
                 14.557 
                 6.0799 
                 2.8 
               
               
                 15.63 
                 5.665 
                 29 
               
               
                 15.88 
                 5.5764 
                 14 
               
               
                 16.43 
                 5.3909 
                 24.7 
               
               
                 16.831 
                 5.2633 
                 12.4 
               
               
                 17.08 
                 5.187 
                 11.2 
               
               
                 17.691 
                 5.0092 
                 6.1 
               
               
                 18.591 
                 4.7687 
                 11.5 
               
               
                 19.03 
                 4.6597 
                 35.7 
               
               
                 19.609 
                 4.5234 
                 8.9 
               
               
                 20.157 
                 4.4017 
                 3.6 
               
               
                 20.48 
                 4.333 
                 27.5 
               
               
                 20.72 
                 4.2833 
                 52.5 
               
               
                 20.97 
                 4.2329 
                 28.5 
               
               
                 21.4 
                 4.1487 
                 13.1 
               
               
                 21.85 
                 4.0642 
                 8.8 
               
               
                 22.96 
                 3.8703 
                 14.6 
               
               
                 23.29 
                 3.8162 
                 3.1 
               
               
                 23.607 
                 3.7656 
                 1.5 
               
               
                 24.11 
                 3.6882 
                 3.2 
               
               
                 24.4 
                 3.645 
                 9.9 
               
               
                 24.811 
                 3.5855 
                 3.6 
               
               
                 25.359 
                 3.5093 
                 3 
               
               
                 26.03 
                 3.4204 
                 27.9 
               
               
                 26.86 
                 3.3164 
                 2.2 
               
               
                 27.37 
                 3.2558 
                 9.6 
               
               
                 27.719 
                 3.2156 
                 2.7 
               
               
                 28.32 
                 3.1488 
                 2.8 
               
               
                 29.669 
                 3.0086 
                 6.2 
               
               
                 30.512 
                 2.9274 
                 2.9 
               
               
                 31.31 
                 2.8546 
                 2.9 
               
               
                 31.719 
                 2.8186 
                 3.9 
               
               
                 32.759 
                 2.7315 
                 4.2 
               
               
                 33.58 
                 2.6665 
                 2.1 
               
               
                 34.059 
                 2.6301 
                 2.3 
               
               
                 34.802 
                 2.5757 
                 1.6 
               
               
                 35.351 
                 2.5369 
                 0.7 
               
               
                 35.921 
                 2.498 
                 1.6 
               
               
                 37.677 
                 2.3855 
                 1.4 
               
               
                 38.27 
                 2.3499 
                 1.5 
               
               
                 39.21 
                 2.2957 
                 1.3 
               
               
                   
               
            
           
         
       
     
     41) The Maleate Crystalline Form XLI of Compound 1 
     In one embodiment, the form is the maleate crystalline Form XLI of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.12±0.2°, 8.12±0.2°, 14.68±0.2°, 16.83±0.2°, 18.35±0.2°, 19.32±0.2°, 21.11±0.2°, 23.66±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 40 below and/or an XRPD pattern substantially as shown in  FIG.  121   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 1.4±0.2% by weight before 154.0° C.; and a weight loss of 8.3±0.2% by weight between 154.0-227.8° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 193.6±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  122   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  123   . 
     
       
         
           
               
               
               
             
               
                 TABLE 40 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.122 
                 17.2402 
                 49.8 
               
               
                 7.596 
                 11.6281 
                 11.1 
               
               
                 8.124 
                 10.8747 
                 46.1 
               
               
                 9.333 
                 9.4684 
                 7.5 
               
               
                 10.013 
                 8.8266 
                 26.4 
               
               
                 10.89 
                 8.1176 
                 11.8 
               
               
                 11.299 
                 7.8244 
                 16.9 
               
               
                 12.546 
                 7.0495 
                 13.2 
               
               
                 13.129 
                 6.7377 
                 29.9 
               
               
                 14.688 
                 6.0259 
                 100 
               
               
                 15.74 
                 5.6254 
                 10.5 
               
               
                 16.093 
                 5.5029 
                 24.1 
               
               
                 16.83 
                 5.2636 
                 52.1 
               
               
                 17.025 
                 5.2036 
                 38.1 
               
               
                 18.351 
                 4.8305 
                 50.7 
               
               
                 19.324 
                 4.5895 
                 71.6 
               
               
                 19.599 
                 4.5258 
                 17.5 
               
               
                 19.966 
                 4.4434 
                 10.2 
               
               
                 20.61 
                 4.306 
                 10.9 
               
               
                 21.117 
                 4.2037 
                 51.5 
               
               
                 21.721 
                 4.0881 
                 40.1 
               
               
                 22.17 
                 4.0063 
                 30.1 
               
               
                 22.478 
                 3.9521 
                 30.9 
               
               
                 23.084 
                 3.8498 
                 9.4 
               
               
                 23.667 
                 3.7562 
                 96.4 
               
               
                 24.274 
                 3.6637 
                 9 
               
               
                 24.913 
                 3.5711 
                 9.5 
               
               
                 25.185 
                 3.5331 
                 10.5 
               
               
                 26.065 
                 3.4158 
                 31.2 
               
               
                 26.572 
                 3.3517 
                 16.3 
               
               
                 27.934 
                 3.1913 
                 24.2 
               
               
                 28.512 
                 3.1279 
                 3.8 
               
               
                 29.104 
                 3.0657 
                 21.1 
               
               
                 29.578 
                 3.0176 
                 3.3 
               
               
                 30.001 
                 2.976 
                 16.1 
               
               
                 30.697 
                 2.9101 
                 3.8 
               
               
                 31.672 
                 2.8227 
                 10.1 
               
               
                 32.338 
                 2.7661 
                 5 
               
               
                 33.156 
                 2.6997 
                 9 
               
               
                 33.949 
                 2.6384 
                 6.4 
               
               
                 34.91 
                 2.568 
                 4.8 
               
               
                 35.747 
                 2.5097 
                 3.2 
               
               
                 36.332 
                 2.4707 
                 3.6 
               
               
                 37.164 
                 2.4172 
                 3.7 
               
               
                 37.634 
                 2.3881 
                 6.7 
               
               
                 38.75 
                 2.3219 
                 4.9 
               
               
                 39.429 
                 2.2834 
                 4.9 
               
               
                   
               
            
           
         
       
     
     42) The Maleate Crystalline Form XLII of Compound 1 
     In one embodiment, the form is the maleate crystalline Form XLII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.2±0.2°, 16.80±0.2°, 19.36±0.2°, 19.65±0.2°, 21.00±0.2°, 26.04±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 41 below and/or an XRPD pattern substantially as shown in  FIG.  124   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 1.6±0.2% by weight before 122.6° C.; a weight loss of 7.6±0.2% by weight between 122.6° C.-188.40° C.; and a weight loss of 5.0±0.2% by weight between 188.40° C.-228.10° C.; 
     2) In the DSC curve, there are three endothermic peaks at the initial temperature of 157.8±2.0° C. 184.3±2.0° C. and 218.8±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  125   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  126   . 
     
       
         
           
               
               
               
             
               
                 TABLE 41 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.2 
                 16.9819 
                 76 
               
               
                 8.222 
                 10.7443 
                 11 
               
               
                 8.531 
                 10.3563 
                 6.5 
               
               
                 9.075 
                 9.7371 
                 12.3 
               
               
                 9.839 
                 8.9824 
                 17.2 
               
               
                 10.927 
                 8.0903 
                 14.5 
               
               
                 11.981 
                 7.3805 
                 15.9 
               
               
                 12.525 
                 7.0614 
                 18.3 
               
               
                 12.622 
                 7.0072 
                 17.2 
               
               
                 13.42 
                 6.5926 
                 4.5 
               
               
                 14.159 
                 6.2499 
                 9.6 
               
               
                 14.526 
                 6.0929 
                 11.5 
               
               
                 15.364 
                 5.7624 
                 10.2 
               
               
                 16.128 
                 5.4911 
                 14.3 
               
               
                 16.807 
                 5.2707 
                 29.8 
               
               
                 17.257 
                 5.1344 
                 22.5 
               
               
                 17.652 
                 5.0203 
                 14.7 
               
               
                 18.076 
                 4.9034 
                 10.1 
               
               
                 18.914 
                 4.688 
                 15.4 
               
               
                 19.362 
                 4.5806 
                 38.9 
               
               
                 19.653 
                 4.5133 
                 31.5 
               
               
                 21.001 
                 4.2267 
                 100 
               
               
                 22.087 
                 4.0212 
                 16.4 
               
               
                 23.103 
                 3.8467 
                 24.5 
               
               
                 24.665 
                 3.6064 
                 16.4 
               
               
                 25.088 
                 3.5466 
                 7.6 
               
               
                 26.045 
                 3.4183 
                 41.5 
               
               
                 27.158 
                 3.2808 
                 7.6 
               
               
                 27.805 
                 3.2059 
                 9.3 
               
               
                 28.342 
                 3.1464 
                 11.2 
               
               
                 29.655 
                 3.01 
                 12.4 
               
               
                 30.153 
                 2.9614 
                 6.3 
               
               
                 33.642 
                 2.6618 
                 6.3 
               
               
                   
               
            
           
         
       
     
     43) The Maleate Crystalline Form XLIII of Compound 1 
     In one embodiment, the form is the maleate crystalline Form XLIII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.18±0.2°, 15.60±0.2°, 15.99±0.2°, 17.04±0.2°, 19.18±0.2°, 20.86±0.2°, 25.98±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 42 below and/or an XRPD pattern substantially as shown in  FIG.  127   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 11.5±0.2% by weight before 187.4° C.; and a weight loss of 5.2±0.2% by weight between 187.4° C.-227.8° C.; 
     2) In the DSC curve, there are three endothermic peaks at the initial temperature of 148.0±2.0° C., 180.2±2.0° C. and 214.9±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  128   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  129   . 
     
       
         
           
               
               
               
             
               
                 TABLE 42 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.181 
                 17.0431 
                 100 
               
               
                 8.919 
                 9.907 
                 4.4 
               
               
                 9.561 
                 9.2424 
                 4.3 
               
               
                 10.167 
                 8.6929 
                 10.1 
               
               
                 11 
                 8.0365 
                 5.3 
               
               
                 11.648 
                 7.5911 
                 9.2 
               
               
                 12.446 
                 7.1061 
                 5.6 
               
               
                 13.651 
                 6.4814 
                 2.2 
               
               
                 14.383 
                 6.1532 
                 6.7 
               
               
                 15.602 
                 5.6749 
                 27.7 
               
               
                 15.993 
                 5.5372 
                 31.1 
               
               
                 16.266 
                 5.4447 
                 16.8 
               
               
                 17.046 
                 5.1973 
                 25.2 
               
               
                 17.771 
                 4.9869 
                 7.5 
               
               
                 18.606 
                 4.765 
                 13.3 
               
               
                 19.189 
                 4.6215 
                 37.7 
               
               
                 19.912 
                 4.4552 
                 6.9 
               
               
                 20.862 
                 4.2545 
                 75.7 
               
               
                 21.481 
                 4.1333 
                 12.3 
               
               
                 21.838 
                 4.0665 
                 9.6 
               
               
                 22.97 
                 3.8686 
                 14.4 
               
               
                 24.662 
                 3.6069 
                 18.5 
               
               
                 25.542 
                 3.4845 
                 7.1 
               
               
                 25.987 
                 3.4259 
                 33.4 
               
               
                 27.586 
                 3.2308 
                 14.9 
               
               
                 28.208 
                 3.161 
                 8.2 
               
               
                 28.599 
                 3.1186 
                 4.5 
               
               
                 29.571 
                 3.0183 
                 8.9 
               
               
                 30.583 
                 2.9207 
                 5.4 
               
               
                 31.694 
                 2.8208 
                 5.1 
               
               
                 37.944 
                 2.3693 
                 4.8 
               
               
                   
               
            
           
         
       
     
     44) The Maleate Crystalline Form XLIV of Compound 1 
     In one embodiment, the form is the maleate crystalline Form XLIV of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.20±0.2°, 6.03±0.2°, 13.5±0.2°, 16.88±0.2°, 17.70±0.2°, 18.75±0.2°, 19.16±0.2°, 19.77±0.2°, 20.97±0.2°, 21.72±0.2°, 24.77±0.2°, 28.65±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 43 below and/or an XRPD pattern substantially as shown in  FIG.  130   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.2±0.10% by weight before 102.1° C.; a weight loss of 5.0±0.2% by weight between 102.1° C.-188.8° C.; and a weight loss of 2.4±0.2% by weight between 188.8° C.-228.5° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperature of 192.0±2.0° C. and 228.0±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  131   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  132   . 
     
       
         
           
               
               
               
             
               
                 TABLE 43 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.203 
                 16.97 
                 100 
               
               
                 6.039 
                 14.6236 
                 87.2 
               
               
                 6.7 
                 13.1815 
                 24.5 
               
               
                 9.58 
                 9.2242 
                 38.3 
               
               
                 12.252 
                 7.2178 
                 32.7 
               
               
                 12.585 
                 7.0277 
                 37.8 
               
               
                 13.5 
                 6.5537 
                 58.2 
               
               
                 14.303 
                 6.1875 
                 14.3 
               
               
                 15.108 
                 5.8595 
                 20.4 
               
               
                 15.993 
                 5.5371 
                 27.6 
               
               
                 16.541 
                 5.3548 
                 36.7 
               
               
                 16.889 
                 5.2452 
                 68.9 
               
               
                 17.709 
                 5.0044 
                 59.7 
               
               
                 18.194 
                 4.8719 
                 30.1 
               
               
                 18.758 
                 4.7267 
                 78.6 
               
               
                 19.164 
                 4.6274 
                 50 
               
               
                 19.773 
                 4.4863 
                 81.1 
               
               
                 20.979 
                 4.231 
                 99.5 
               
               
                 21.72 
                 4.0883 
                 79.1 
               
               
                 22.442 
                 3.9583 
                 42.3 
               
               
                 22.97 
                 3.8686 
                 14.8 
               
               
                 24.779 
                 3.5902 
                 90.8 
               
               
                 25.419 
                 3.5011 
                 23 
               
               
                 26.141 
                 3.4061 
                 18.9 
               
               
                 28.656 
                 3.1125 
                 60.7 
               
               
                 33.937 
                 2.6394 
                 17.9 
               
               
                   
               
            
           
         
       
     
     45) The Tartrate Crystalline Form XLV of Compound 1 
     In one embodiment, the form is the tartrate crystalline Form XLV of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 3.88±0.2°, 5.91±0.2°, 15.6±0.2°, 18.04±0.2°, 18.4±0.2°, 19.44±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 44 below and/or an XRPD pattern substantially as shown in  FIG.  133   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 1.1±0.2% by weight before 76.6° C.; a weight loss of 1.4±0.2% by weight between 76.6° C.-155.7° C.; and a weight loss of 12.6±0.2% by weight between 155.7° C.-242.0° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 155.9±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  134   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  135   . 
     
       
         
           
               
               
               
             
               
                 TABLE 44 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 3.88 
                 22.7539 
                 100 
               
               
                 5.919 
                 14.9181 
                 46.6 
               
               
                 7.771 
                 11.3679 
                 18.3 
               
               
                 8.92 
                 9.9055 
                 19.9 
               
               
                 10.209 
                 8.6574 
                 13.8 
               
               
                 11.879 
                 7.4439 
                 9.4 
               
               
                 12.31 
                 7.184 
                 9 
               
               
                 14.04 
                 6.3026 
                 12 
               
               
                 14.513 
                 6.0984 
                 6.5 
               
               
                 15.6 
                 5.6757 
                 36.1 
               
               
                 16.02 
                 5.528 
                 28.8 
               
               
                 16.549 
                 5.3523 
                 23.1 
               
               
                 18.04 
                 4.9131 
                 67 
               
               
                 18.4 
                 4.8177 
                 61.2 
               
               
                 19.44 
                 4.5623 
                 74.9 
               
               
                 20.199 
                 4.3926 
                 25 
               
               
                 21.839 
                 4.0662 
                 11.6 
               
               
                 22.368 
                 3.9713 
                 11.2 
               
               
                 22.9 
                 3.8802 
                 17.1 
               
               
                 23.87 
                 3.7248 
                 15 
               
               
                 25.63 
                 3.4728 
                 18 
               
               
                 27.621 
                 3.2269 
                 11.9 
               
               
                 29 
                 3.0765 
                 10.1 
               
               
                   
               
            
           
         
       
     
     46) The Hydrochloride Crystalline Form XLVI of Compound 1 
     In one embodiment, the form is the hydrochloride crystalline Form XLVI of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.09±0.2°, 8.45±0.2°, 12.77±0.2°, 13.45±0.2°, 15.36±0.2°, 18.82±0.2°, 21.42±0.2°, 22.53±0.2°, 23.73±0.2°, 25.73±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 45 below and/or an XRPD pattern substantially as shown in  FIG.  136   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 3.9±0.2% by weight before 83.9° C.; and a weight loss of 3.6±0.2% by weight between 83.9° C.-200.0° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperature of 43.4±2.0° C. and 170.1±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  137   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  138   . 
     
       
         
           
               
               
               
             
               
                 TABLE 45 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.098 
                 17.3194 
                 100 
               
               
                 7.585 
                 11.6449 
                 19.2 
               
               
                 7.958 
                 11.101 
                 4.9 
               
               
                 8.457 
                 10.4469 
                 42.8 
               
               
                 9.079 
                 9.7324 
                 3.2 
               
               
                 9.449 
                 9.3518 
                 5.2 
               
               
                 9.995 
                 8.8427 
                 6.2 
               
               
                 10.364 
                 8.528 
                 3.5 
               
               
                 10.969 
                 8.0594 
                 22.6 
               
               
                 11.763 
                 7.5169 
                 8.2 
               
               
                 12.487 
                 7.0828 
                 4 
               
               
                 12.777 
                 6.9229 
                 43.9 
               
               
                 13.456 
                 6.575 
                 49 
               
               
                 14.66 
                 6.0376 
                 11.6 
               
               
                 15.011 
                 5.8969 
                 10.9 
               
               
                 15.361 
                 5.7635 
                 72.1 
               
               
                 16.118 
                 5.4945 
                 26.2 
               
               
                 16.366 
                 5.4116 
                 3 
               
               
                 16.759 
                 5.2858 
                 14.5 
               
               
                 17.05 
                 5.1961 
                 29.4 
               
               
                 17.651 
                 5.0205 
                 36.9 
               
               
                 18.272 
                 4.8512 
                 11.6 
               
               
                 18.821 
                 4.7111 
                 77.4 
               
               
                 19.52 
                 4.544 
                 8.1 
               
               
                 19.847 
                 4.4697 
                 16.1 
               
               
                 20.271 
                 4.3771 
                 7.4 
               
               
                 20.527 
                 4.3232 
                 2 
               
               
                 20.842 
                 4.2586 
                 10.6 
               
               
                 21.153 
                 4.1966 
                 27.7 
               
               
                 21.426 
                 4.1438 
                 41.7 
               
               
                 21.889 
                 4.0572 
                 7.5 
               
               
                 22.531 
                 3.943 
                 38.5 
               
               
                 23.112 
                 3.8451 
                 8.8 
               
               
                 23.736 
                 3.7455 
                 54.1 
               
               
                 24.279 
                 3.6629 
                 7.5 
               
               
                 24.632 
                 3.6112 
                 16.7 
               
               
                 24.844 
                 3.5808 
                 4.4 
               
               
                 25.14 
                 3.5394 
                 4.5 
               
               
                 25.321 
                 3.5145 
                 4.7 
               
               
                 25.739 
                 3.4583 
                 32.6 
               
               
                 26.01 
                 3.4229 
                 16.8 
               
               
                 26.324 
                 3.3828 
                 13.8 
               
               
                 27.022 
                 3.2969 
                 7.6 
               
               
                 27.625 
                 3.2264 
                 9.7 
               
               
                 27.959 
                 3.1886 
                 3.1 
               
               
                 28.518 
                 3.1273 
                 16.6 
               
               
                 29.101 
                 3.066 
                 5.8 
               
               
                 30.206 
                 2.9563 
                 8.4 
               
               
                 30.539 
                 2.9249 
                 1.9 
               
               
                 30.907 
                 2.8909 
                 4.2 
               
               
                 31.165 
                 2.8675 
                 8.8 
               
               
                 32.271 
                 2.7717 
                 5.7 
               
               
                 32.592 
                 2.7452 
                 3.1 
               
               
                 33.842 
                 2.6465 
                 8.3 
               
               
                 35.046 
                 2.5583 
                 2.6 
               
               
                 36.336 
                 2.4704 
                 2.8 
               
               
                 37.246 
                 2.4121 
                 3.1 
               
               
                 37.497 
                 2.3965 
                 3.5 
               
               
                 38.18 
                 2.3552 
                 4.2 
               
               
                   
               
            
           
         
       
     
     47) The Hydrochloride Crystalline Form XL VII of Compound 1 
     In one embodiment, the form is the hydrochloride crystalline Form XLVII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 5.9±0.2°, 11.79±0.2°, 14.45±0.2°, 16.65±0.2°, 20.46±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 46 below and/or an XRPD pattern substantially as shown in  FIG.  139   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.54±0.2% by weight before 149.0° C.; and a weight loss of 1.86±0.2% by weight between 149.0° C.-208.3° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 196.6±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  140   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  141   . 
     
       
         
           
               
               
               
             
               
                 TABLE 46 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 5.9 
                 14.9683 
                 100 
               
               
                 9.19 
                 9.615 
                 1.8 
               
               
                 10.119 
                 8.7339 
                 2.3 
               
               
                 11.799 
                 7.4939 
                 7.1 
               
               
                 12.66 
                 6.9865 
                 0.8 
               
               
                 12.949 
                 6.831 
                 1.8 
               
               
                 13.279 
                 6.6619 
                 1.3 
               
               
                 13.68 
                 6.4676 
                 1.2 
               
               
                 14.45 
                 6.1246 
                 6.4 
               
               
                 15.22 
                 5.8165 
                 1.3 
               
               
                 15.649 
                 5.6579 
                 3.4 
               
               
                 16.17 
                 5.4768 
                 7.9 
               
               
                 16.65 
                 5.3201 
                 24.5 
               
               
                 17.36 
                 5.104 
                 2.7 
               
               
                 17.549 
                 5.0494 
                 4.3 
               
               
                 18.28 
                 4.8492 
                 5.3 
               
               
                 18.62 
                 4.7614 
                 6.4 
               
               
                 19 
                 4.667 
                 3.7 
               
               
                 19.339 
                 4.586 
                 1.1 
               
               
                 19.76 
                 4.4892 
                 1.8 
               
               
                 20.161 
                 4.4008 
                 1.7 
               
               
                 20.46 
                 4.3371 
                 7.4 
               
               
                 20.799 
                 4.2672 
                 2.9 
               
               
                 21.43 
                 4.143 
                 4.8 
               
               
                 21.79 
                 4.0754 
                 2.4 
               
               
                 22.171 
                 4.0062 
                 1.7 
               
               
                 22.45 
                 3.9571 
                 3.6 
               
               
                 22.889 
                 3.8821 
                 1.7 
               
               
                 23.43 
                 3.7937 
                 3.3 
               
               
                 24.081 
                 3.6926 
                 1.6 
               
               
                 24.46 
                 3.6363 
                 2 
               
               
                 25.119 
                 3.5423 
                 4.4 
               
               
                 25.998 
                 3.4244 
                 0.8 
               
               
                 26.539 
                 3.3559 
                 0.8 
               
               
                 26.83 
                 3.3202 
                 1.7 
               
               
                 27.263 
                 3.2684 
                 0.9 
               
               
                 28.191 
                 3.1629 
                 2.9 
               
               
                 29.309 
                 3.0447 
                 2 
               
               
                 29.94 
                 2.982 
                 2 
               
               
                 30.76 
                 2.9043 
                 0.8 
               
               
                 33.45 
                 2.6766 
                 1 
               
               
                 34.979 
                 2.5631 
                 0.9 
               
               
                 35.311 
                 2.5397 
                 0.8 
               
               
                 36.599 
                 2.4532 
                 0.7 
               
               
                 37.441 
                 2.4 
                 0.7 
               
               
                   
               
            
           
         
       
     
     48) The Hydrochloride Crystalline Form XLVIII of Compound 1 
     In one embodiment, the form is the hydrochloride crystalline Form XLVIII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 6.93±0.2°, 10.51±0.2°, 10.88±0.2°, 13.63±0.2°, 14.04±0.2°, 16.77±0.2°, 21.36±0.2°, 21.83±0.2°, 24.27±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 47 below and/or an XRPD pattern substantially as shown in  FIG.  142   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 3.5±0.2% by weight before 137.2° C.; and a weight loss of 0.57±0.2% by weight between 137.2° C.-198.4° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 175.6±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  143   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  144   . 
     
       
         
           
               
               
               
             
               
                 TABLE 47 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.935 
                 12.736 
                 49.9 
               
               
                 8.393 
                 10.5265 
                 6.3 
               
               
                 10.518 
                 8.4035 
                 100 
               
               
                 10.888 
                 8.1192 
                 34.7 
               
               
                 12.525 
                 7.0614 
                 12.5 
               
               
                 13.638 
                 6.4876 
                 36.7 
               
               
                 14.047 
                 6.2994 
                 48 
               
               
                 16.773 
                 5.2815 
                 30.9 
               
               
                 17.418 
                 5.0873 
                 17.8 
               
               
                 17.98 
                 4.9293 
                 13.3 
               
               
                 18.274 
                 4.8507 
                 21.6 
               
               
                 18.934 
                 4.6831 
                 18.7 
               
               
                 20.314 
                 4.3679 
                 23.1 
               
               
                 20.76 
                 4.2752 
                 11.2 
               
               
                 21.367 
                 4.155 
                 64.6 
               
               
                 21.836 
                 4.0668 
                 30.2 
               
               
                 22.618 
                 3.928 
                 6.3 
               
               
                 23.025 
                 3.8594 
                 21.4 
               
               
                 23.609 
                 3.7653 
                 19.5 
               
               
                 24.272 
                 3.6639 
                 30.3 
               
               
                 24.816 
                 3.5848 
                 13.4 
               
               
                 25.798 
                 3.4506 
                 7.2 
               
               
                 26.317 
                 3.3836 
                 18.6 
               
               
                 26.957 
                 3.3048 
                 5 
               
               
                 27.815 
                 3.2047 
                 7.1 
               
               
                 28.695 
                 3.1084 
                 16 
               
               
                 32.294 
                 2.7697 
                 9.8 
               
               
                 33.329 
                 2.6861 
                 5.6 
               
               
                   
               
            
           
         
       
     
     49) The Hydrochloride Crystalline Form XLIX of Compound 1 
     In one embodiment, the form is the hydrochloride crystalline Form XLIX of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 6.02±0.2°, 10.28±0.2°, 14.66±0.2°, 16.83±0.2°, 20.64±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 48 below and/or an XRPD pattern substantially as shown in  FIG.  145   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.12±0.02% by weight before 158.3° C.; and a weight loss of 1.0±0.2% by weight between 158.3° C.-209.3° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 191.7±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  146   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  147   . 
     
       
         
           
               
               
               
             
               
                 TABLE 48 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.021 
                 14.6669 
                 100 
               
               
                 9.367 
                 9.4341 
                 10.8 
               
               
                 10.286 
                 8.5933 
                 30.4 
               
               
                 11.311 
                 7.8163 
                 5.5 
               
               
                 11.615 
                 7.6126 
                 4.6 
               
               
                 11.958 
                 7.3947 
                 7.2 
               
               
                 13.831 
                 6.3976 
                 8.3 
               
               
                 14.667 
                 6.0344 
                 35.8 
               
               
                 15.428 
                 5.7385 
                 11 
               
               
                 16.167 
                 5.4777 
                 22 
               
               
                 16.83 
                 5.2635 
                 51.5 
               
               
                 17.691 
                 5.0093 
                 7.9 
               
               
                 18.488 
                 4.7952 
                 27 
               
               
                 18.816 
                 4.7122 
                 26.6 
               
               
                 19.148 
                 4.6314 
                 19.8 
               
               
                 20.356 
                 4.3591 
                 20 
               
               
                 20.647 
                 4.2983 
                 44.7 
               
               
                 21.585 
                 4.1135 
                 13.2 
               
               
                 22.016 
                 4.0341 
                 7.3 
               
               
                 22.558 
                 3.9382 
                 7.4 
               
               
                 23.024 
                 3.8596 
                 23.1 
               
               
                 23.648 
                 3.7591 
                 12.5 
               
               
                 24.603 
                 3.6154 
                 12.1 
               
               
                 25.324 
                 3.514 
                 9.8 
               
               
                 26.944 
                 3.3064 
                 11 
               
               
                 27.603 
                 3.2289 
                 6.8 
               
               
                 28.363 
                 3.144 
                 20.5 
               
               
                 29.515 
                 3.024 
                 9.7 
               
               
                 31.691 
                 2.8211 
                 3.9 
               
               
                   
               
            
           
         
       
     
     50) The Hydrochloride Crystalline Form L of Compound 1 
     In one embodiment, the form is the hydrochloride crystalline Form L of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 6.91±0.2°, 7.19±0.2°, 12.97±0.2°, 19.45±0.2°, 20.53±0.2°, 23.10±0.2°, 25.53±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 49 below and/or an XRPD pattern substantially as shown in  FIG.  148   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 2.5±0.2% by weight before 203.7° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 180.9±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  149   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  150   . 
     
       
         
           
               
               
               
             
               
                 TABLE 49 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.915 
                 12.7724 
                 51.1 
               
               
                 7.19 
                 12.2843 
                 46.1 
               
               
                 8.529 
                 10.359 
                 21.4 
               
               
                 10.357 
                 8.5345 
                 12.8 
               
               
                 12.972 
                 6.8192 
                 86.7 
               
               
                 14.03 
                 6.3073 
                 16.4 
               
               
                 15.719 
                 5.633 
                 34.7 
               
               
                 16.341 
                 5.42 
                 22.8 
               
               
                 16.773 
                 5.2813 
                 36.7 
               
               
                 16.946 
                 5.2277 
                 31.9 
               
               
                 17.218 
                 5.1457 
                 20.6 
               
               
                 17.745 
                 4.994 
                 17.8 
               
               
                 18.504 
                 4.7909 
                 18.3 
               
               
                 19.459 
                 4.5579 
                 100 
               
               
                 20.535 
                 4.3215 
                 41.7 
               
               
                 21.251 
                 4.1775 
                 39.2 
               
               
                 21.583 
                 4.1139 
                 17.8 
               
               
                 22.17 
                 4.0064 
                 26.7 
               
               
                 22.763 
                 3.9034 
                 13.1 
               
               
                 23.103 
                 3.8466 
                 63.9 
               
               
                 23.71 
                 3.7494 
                 25 
               
               
                 24.503 
                 3.63 
                 9.2 
               
               
                 24.936 
                 3.5678 
                 34.2 
               
               
                 25.536 
                 3.4854 
                 40.6 
               
               
                 26.506 
                 3.36 
                 9.7 
               
               
                 27.06 
                 3.2925 
                 10.8 
               
               
                 28.094 
                 3.1736 
                 36.1 
               
               
                 28.849 
                 3.0922 
                 18.6 
               
               
                 29.804 
                 2.9953 
                 16.9 
               
               
                 31.574 
                 2.8313 
                 11.7 
               
               
                 34.474 
                 2.5994 
                 8.6 
               
               
                   
               
            
           
         
       
     
     51) The Hydrochloride Crystalline Form LI of Compound 1 
     In one embodiment, the form is the hydrochloride crystalline Form LI of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 4.88±0.2°, 8.51±0.2°, 12.46±0.2°, 18.15±0.2°, 18.50±0.2°, 19.13±0.2°, 20.78±0.2°, 21.11±0.2°, 22.82±0.2°, 24.68±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 50 below and/or an XRPD pattern substantially as shown in  FIG.  151   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.40±0.2% by weight before 72.6° C.; a weight loss of 5.0±0.2% by weight between 72.6° C.-159.0° C.; and a weight loss of 1.31±0.2% by weight between 159.0° C.-199.4° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 183.3±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  152   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  153   . 
     
       
         
           
               
               
               
             
               
                 TABLE 50 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.889 
                 18.0594 
                 87.7 
               
               
                 7.635 
                 11.57 
                 15.4 
               
               
                 8.513 
                 10.378 
                 45 
               
               
                 9.936 
                 8.8943 
                 24.8 
               
               
                 12.467 
                 7.094 
                 74.5 
               
               
                 14.258 
                 6.2068 
                 22.6 
               
               
                 14.975 
                 5.911 
                 11.3 
               
               
                 15.873 
                 5.5788 
                 21.1 
               
               
                 16.867 
                 5.252 
                 37.6 
               
               
                 17.414 
                 5.0883 
                 17 
               
               
                 18.155 
                 4.8823 
                 100 
               
               
                 18.506 
                 4.7905 
                 55.9 
               
               
                 19.13 
                 4.6356 
                 60.2 
               
               
                 19.867 
                 4.4652 
                 19.9 
               
               
                 20.786 
                 4.2699 
                 47 
               
               
                 21.114 
                 4.2043 
                 43.9 
               
               
                 21.985 
                 4.0397 
                 13.6 
               
               
                 22.829 
                 3.8922 
                 57.7 
               
               
                 23.476 
                 3.7864 
                 25.5 
               
               
                 24.68 
                 3.6043 
                 54.8 
               
               
                 25.32 
                 3.5146 
                 8.8 
               
               
                 25.864 
                 3.4419 
                 10.3 
               
               
                 26.22 
                 3.3959 
                 21.1 
               
               
                 26.979 
                 3.3021 
                 16.6 
               
               
                 27.293 
                 3.2648 
                 24.6 
               
               
                 29.216 
                 3.0542 
                 11.3 
               
               
                 30.487 
                 2.9297 
                 9.9 
               
               
                 32.966 
                 2.7148 
                 9.6 
               
               
                 33.395 
                 2.6809 
                 6.8 
               
               
                 35.084 
                 2.5557 
                 9 
               
               
                   
               
            
           
         
       
     
     52) The Hydrochloride Crystalline Form LII of Compound 1 
     In one embodiment, the form is the hydrochloride crystalline Form LII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 6.19±0.2°, 16.36±0.2°, 19.01±0.2°, 21.21±0.2°, 21.87±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 51 below and/or an XRPD pattern substantially as shown in  FIG.  154   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.01±0.002% by weight before 145.8° C.; and a weight loss of 1.92±0.2% by weight between 145.8° C.-206.0° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 198.1±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  155   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  156   . 
     
       
         
           
               
               
               
             
               
                 TABLE 51 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.194 
                 14.2581 
                 100 
               
               
                 10.538 
                 8.3881 
                 14.7 
               
               
                 11.476 
                 7.7044 
                 7.5 
               
               
                 12.274 
                 7.205 
                 7.7 
               
               
                 13.44 
                 6.5825 
                 13.6 
               
               
                 14.03 
                 6.307 
                 8.6 
               
               
                 15.945 
                 5.5537 
                 11.9 
               
               
                 16.365 
                 5.412 
                 56.5 
               
               
                 19.011 
                 4.6643 
                 20.7 
               
               
                 19.611 
                 4.523 
                 17.8 
               
               
                 20.369 
                 4.3563 
                 9.1 
               
               
                 21.213 
                 4.1848 
                 20.7 
               
               
                 21.876 
                 4.0596 
                 23.5 
               
               
                 22.534 
                 3.9424 
                 5 
               
               
                 23.204 
                 3.83 
                 6.3 
               
               
                 24.389 
                 3.6466 
                 7.8 
               
               
                 24.853 
                 3.5796 
                 13.6 
               
               
                 27.095 
                 3.2882 
                 5.6 
               
               
                 27.934 
                 3.1914 
                 14.9 
               
               
                 30.48 
                 2.9304 
                 7 
               
               
                   
               
            
           
         
       
     
     53) The Hydrochloride Crystalline Form LIII of Compound 1 
     In one embodiment, the form is the hydrochloride crystalline Form LIII of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 8.45±0.2°, 8.78±0.2θ, 13.28±0.2°, 14.02±0.2°, 15.29±0.2°, 16.03±0.2°, 16.79±0.2°, 17.08±0.2°, 19.30±0.2°, 21.99±0.2°, 22.61±0.2°, 24.83±0.2°, 25.18±0.2θ. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 52 below and/or an XRPD pattern substantially as shown in  FIG.  157   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.51±0.2% by weight before 65.4° C.; and a weight loss of 5.6±0.2% by weight between 65.4° C.-197.0° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 105.6±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  158   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  159   . 
     
       
         
           
               
               
               
             
               
                 TABLE 52 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 6.407 
                 13.7848 
                 37.6 
               
               
                 6.814 
                 12.9624 
                 30.3 
               
               
                 8.453 
                 10.4519 
                 99.4 
               
               
                 8.785 
                 10.0571 
                 84.3 
               
               
                 9.953 
                 8.8795 
                 18.5 
               
               
                 11.396 
                 7.7583 
                 36 
               
               
                 12.698 
                 6.9657 
                 43.3 
               
               
                 13.284 
                 6.6593 
                 51.7 
               
               
                 14.028 
                 6.3081 
                 66.9 
               
               
                 15.291 
                 5.7897 
                 51.7 
               
               
                 16.033 
                 5.5232 
                 67.4 
               
               
                 16.793 
                 5.275 
                 53.9 
               
               
                 17.084 
                 5.1859 
                 100 
               
               
                 17.572 
                 5.0429 
                 43.3 
               
               
                 18.893 
                 4.6932 
                 32.6 
               
               
                 19.303 
                 4.5944 
                 98.3 
               
               
                 19.905 
                 4.4568 
                 29.8 
               
               
                 21.993 
                 4.0381 
                 59.6 
               
               
                 22.614 
                 3.9287 
                 82 
               
               
                 23.473 
                 3.7868 
                 31.5 
               
               
                 24.839 
                 3.5815 
                 57.9 
               
               
                 25.188 
                 3.5327 
                 69.1 
               
               
                 26.231 
                 3.3945 
                 24.2 
               
               
                 26.919 
                 3.3094 
                 21.3 
               
               
                 28.46 
                 3.1335 
                 46.6 
               
               
                 32.883 
                 2.7215 
                 20.2 
               
               
                   
               
            
           
         
       
     
     54) The Hydrochloride Crystalline Form LIV of Compound 1 
     In one embodiment, the form is the hydrochloride crystalline Form LIV of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 4.30±0.2°, 5.78±0.2°, 11.31±0.2°, 17.86±0.2°, 18.46±0.2°, 19.24±0.2°, 19.71±0.2°, 21.05±0.2°, 24.75±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 53 below and/or an XRPD pattern substantially as shown in  FIG.  160   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 1.8±0.2% by weight before 207.0° C.; 
     2) In the DSC curve, there are two endothermic peaks at the initial temperature of 169.6±2.0° C. and 196.7±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  161   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  162   . 
     
       
         
           
               
               
               
             
               
                 TABLE 53 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.305 
                 20.509 
                 21.7 
               
               
                 5.785 
                 15.2633 
                 100 
               
               
                 10.344 
                 8.5448 
                 12.1 
               
               
                 11.319 
                 7.8108 
                 25.5 
               
               
                 13.831 
                 6.3972 
                 19.2 
               
               
                 14.959 
                 5.9174 
                 14.4 
               
               
                 15.639 
                 5.6617 
                 16.5 
               
               
                 16.485 
                 5.373 
                 17.9 
               
               
                 17.862 
                 4.9617 
                 41.5 
               
               
                 18.468 
                 4.8003 
                 31.5 
               
               
                 19.248 
                 4.6075 
                 23.6 
               
               
                 19.715 
                 4.4993 
                 26.9 
               
               
                 20.571 
                 4.314 
                 6 
               
               
                 21.057 
                 4.2156 
                 23.2 
               
               
                 21.484 
                 4.1327 
                 14.4 
               
               
                 22.053 
                 4.0274 
                 9.4 
               
               
                 22.672 
                 3.9187 
                 19 
               
               
                 23.394 
                 3.7995 
                 7.1 
               
               
                 24.757 
                 3.5932 
                 23.4 
               
               
                 25.945 
                 3.4314 
                 11.3 
               
               
                 26.332 
                 3.3817 
                 16.7 
               
               
                 26.702 
                 3.3358 
                 6.3 
               
               
                 28.188 
                 3.1632 
                 10.2 
               
               
                 29.194 
                 3.0564 
                 9.4 
               
               
                 31.562 
                 2.8323 
                 7.9 
               
               
                 36.968 
                 2.4296 
                 7.7 
               
               
                   
               
            
           
         
       
     
     55) The Hydrochloride Crystalline Form LV of Compound 1 
     In one embodiment, the form is the hydrochloride crystalline Form LV of the compound 1, which is characterized by having at least three, at least four or five characteristic peaks at the following positions in the XRPD pattern represented by angle 2θ: 4.90±0.2°, 14.19±0.2°, 18.66±0.2°, 19.55±0.2°, 21.77±0.2°, 25.18±0.2°. 
     In some preferred embodiments, the form has XRPD characteristic peaks at the positions substantially as shown in Table 54 below and/or an XRPD pattern substantially as shown in  FIG.  163   . 
     In some preferred embodiments, they also have the following characteristics: 
     1) In the TGA plot, there is a weight loss of 0.89±0.2% by weight before 133.9° C.; and a weight loss of 0.94±0.2% by weight between 133.9° C.-198.7° C.; 
     2) In the DSC curve, there is an endothermic peak at the initial temperature of 175.5±2.0° C.; 
     3) the TGA plot substantially as shown in  FIG.  164   ; and/or 
     4) the DSC curve substantially as shown in  FIG.  165   . 
     
       
         
           
               
               
               
             
               
                 TABLE 54 
               
               
                   
               
               
                 Angle[°2θ] ± 0.2° 
                 d-value[Å] 
                 Relative intensity [%] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 4.909 
                 17.9848 
                 20.1 
               
               
                 7.344 
                 12.0271 
                 8 
               
               
                 8.514 
                 10.3767 
                 6.8 
               
               
                 9.894 
                 8.9325 
                 14.4 
               
               
                 10.223 
                 8.6459 
                 15.3 
               
               
                 10.658 
                 8.2934 
                 13.4 
               
               
                 11.61 
                 7.6154 
                 6.2 
               
               
                 11.845 
                 7.4652 
                 10.6 
               
               
                 12.505 
                 7.0724 
                 15.9 
               
               
                 14.198 
                 6.2328 
                 100 
               
               
                 15.117 
                 5.8558 
                 7.4 
               
               
                 16.248 
                 5.4508 
                 4.5 
               
               
                 17.003 
                 5.2104 
                 16.4 
               
               
                 17.707 
                 5.0049 
                 12.3 
               
               
                 18.152 
                 4.8831 
                 15.4 
               
               
                 18.661 
                 4.7511 
                 66.5 
               
               
                 19.171 
                 4.6259 
                 14 
               
               
                 19.559 
                 4.5349 
                 28.7 
               
               
                 19.989 
                 4.4382 
                 18.6 
               
               
                 20.337 
                 4.3632 
                 3.1 
               
               
                 20.761 
                 4.275 
                 9.7 
               
               
                 21.038 
                 4.2193 
                 4 
               
               
                 21.45 
                 4.1391 
                 5.5 
               
               
                 21.776 
                 4.078 
                 33.5 
               
               
                 22.044 
                 4.0289 
                 18.9 
               
               
                 22.751 
                 3.9054 
                 12.7 
               
               
                 23.574 
                 3.7708 
                 13.3 
               
               
                 24.079 
                 3.6928 
                 18.8 
               
               
                 24.699 
                 3.6015 
                 6.8 
               
               
                 25.189 
                 3.5326 
                 27.4 
               
               
                 25.793 
                 3.4513 
                 5.5 
               
               
                 26.103 
                 3.4109 
                 16.7 
               
               
                 26.744 
                 3.3306 
                 10.1 
               
               
                 27.095 
                 3.2882 
                 15.7 
               
               
                 27.499 
                 3.2408 
                 6.2 
               
               
                 28.385 
                 3.1417 
                 8.7 
               
               
                 28.942 
                 3.0825 
                 6.6 
               
               
                 29.866 
                 2.9892 
                 8.3 
               
               
                 30.211 
                 2.9558 
                 4.6 
               
               
                 31.082 
                 2.8749 
                 4.7 
               
               
                 31.807 
                 2.811 
                 5.8 
               
               
                 32.868 
                 2.7227 
                 3.1 
               
               
                 35.33 
                 2.5384 
                 3.6 
               
               
                 37.499 
                 2.3964 
                 3.1 
               
               
                 38.933 
                 2.3114 
                 3.9 
               
               
                   
               
            
           
         
       
     
     In the second respect, the present invention provides a method for preparing the crystalline form or amorphous form of the compound 1 or its salt or solvate. 
     In one embodiment, the present invention provides a method for preparing a crystalline form of the compound 1, which comprises the following steps: mixing the compound 1 with solvent, separating the resulting solid and drying, and thereby obtaining the crystalline form of the compound 1. 
     In the preparation method, the compound 1 can be obtained from a variety of sources, such as commercial purchase or laboratory synthesis. 
     The solvents can be commonly used in laboratory, such as one or more of the water, alkane solvents, alcohol solvents, ketone solvents, ester solvents, aromatic hydrocarbon solvents, halogenated hydrocarbon solvents, nitrile solvents, ether solvents, aliphatic hydrocarbon solvents, polar aprotic solvents such as DMF, DMSO. The mass-volume ratio of the compound 1 to the solvent can be 100 mg: (0.1-1 mL). 
     In one embodiment, the present invention provides a method for preparing crystalline form of solvate of the compound 1, which comprises the following steps: mixing the compound 1 with the solvent corresponding to the type of solvate, separating the resulting solid and drying, and thereby obtaining the crystalline form of the solvate of the compound 1. 
     The solvents corresponding to the type of solvate, such as but not limited to 1,4-dioxane, ethyl acetate, toluene, chloroform, 2-methyltetrahydrofuran, methyl tert-butyl ether, acetone, N,N-dimethylformamide, acetonitrile etc. 
     In one embodiment, the present invention provides a method for preparing crystalline form of salt of the compound 1, which comprises the following steps: mixing the compound 1 with solvent and acid, separating the resulting solid and drying, and thereby obtaining the crystalline form of salt of the compound 1. 
     The solvents can be commonly used in laboratory, such as one or more of water, alkane solvents, alcohol solvents, ketone solvents, ester solvents, aromatic hydrocarbon solvents, halogenated hydrocarbon solvents, nitrile solvents, ether solvents, aliphatic hydrocarbon solvents, polar aprotic solvents such as DMF, DMSO. The acids can be pharmaceutically acceptable acids or common acids in the art, can be inorganic acids or organic acids. Further preferably, the acids can be hydrochloric acid, sulfuric acid, methanesulfonic acid, maleic acid, benzenesulfonic acid, p-toluenesulfonic acid, tartaric acid and citric acid etc. 
     In one embodiment, the present invention provides a method for preparing an amorphous form of the compound 1, which comprises the following steps: mixing the compound 1 with solvents and spray drying the resulting solution to obtain an amorphous form of the compound 1. 
     The solvents can be commonly used in laboratory, such as one or more of water, alkane solvents, alcohol solvents, ketone solvents, ester solvents, aromatic hydrocarbon solvents, halogenated hydrocarbon solvents, nitrile solvents, ether solvents, aliphatic hydrocarbon solvents, polar aprotic solvents such as DMF, DMSO. Methylene dichloride (DCM) is preferred. 
     In each of the above preparation methods, the preparation temperature can be conventional in the art, such as 20-50° C. 
     In the above preparation methods, there are no special limitations on the crystallization time, as long as the crystal can be precipitated, for example, the crystallization time can be 1-48 h. 
     In addition, the preparation methods of the crystalline forms or amorphous forms of compound 1 or salts or its solvates can be well known in the art, for example solvent evaporation method, suspension stirring method, heating and cooling crystallization method and mixed solvent crystallization method. The solvent evaporation method of the present invention is to volatilize the sample clarification solution at different temperatures until the solvent volatile completely. The suspension stirring method of the present invention is to stir the supersaturated solution of the sample (with the presence of insoluble solids) in different solvents for a period of time. The heating and cooling crystallization method of the present invention is to dissolve the sample in appropriate solvents under high temperature condition, and stir the filtrate out in room temperature or low temperature environment after filtration. The mixed solvent crystallization method of the present invention is to take a sample and dissolve it in appropriate solvents, add another one or more solvents, precipitate out a solid system, stir it for a short time for filtration. 
     In the third aspect, the present invention provides a pharmaceutical composition comprising the above-mentioned crystalline forms or amorphous forms of compound 1 or its salts or solvates, and pharmacologically acceptable excipients. 
     The crystalline forms or amorphous forms of compound 1 or its salts or solvates can be a therapeutically effective amount for treatment. The pharmacically acceptable excipients can be well known in the art, which in the case of solid preparations include but are not limited to: diluents, adhesives, disintegrants, lubricants, flow aids, release rate control agents, plasticizers, preservatives, antioxidants, etc. 
     The pharmaceutical compositions can choose the dosage forms suitable for human consumption, such as tablet, capsule, granule, powder, or pill, etc., preferably tablet, capsule, granule, disintegrating tablet, sustained release or controlled release tablet, etc. 
     The pharmaceutical compositions in the present invention can be prepared by various methods that are well known in the art. One or more of crystalline forms or amorphous forms of the compound 1 or its salts and solvates in a therapeutic effective amount can be mixed with one or more of pharmacically acceptable excipients to prepare dosage forms for human consumption, such as tablets, capsules, granules, etc. 
     The “therapeutically effective amount” is the amount of a compound in the form of the present invention that, when administered to a patient in need, is sufficient to achieve treatment of a disease state, condition, or disorder for which the compound has utility. Such a quantity would be sufficient to elicit a biological or medical response in the tissue system or patient sought by researchers or clinicians. 
     In the fourth aspect, the present invention provides the use of the crystalline forms or amorphous forms of above mentioned compound 1 or its salts and solvates or the use of above mentioned pharmaceutical compositions in the preparation of drugs for the prevention and/or treatment of hyperproliferative diseases. 
     In one embodiment, the drugs are preferably used to prevent and/or treat cancers, the cancers including but not limited to acute mononuclear leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, chronic lymphocytic leukemia mixed lineage leukemia, the NUT midline carcinoma, multiple myeloma, small cell lung cancer, neuroblastoma, burkitt lymphoma, cervical cancer, esophageal cancer, ovarian cancer, colorectal cancer, prostate cancer and breast cancer. 
     The crystalline forms or amorphous forms of the compound 1 or its salts and solvstes have the following advantages: 
     The present invention for the first time discovers a variety of unreported crystalline forms or amorphous forms of the compound 1 or its salts and solvates, which can serve as an important basis for subsequent drug development, preparation development and production. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG.  1    is an XRPD pattern of Compound 1 crystalline Form I. 
         FIG.  2    is a TGA plot of Compound 1 crystalline Form I. 
         FIG.  3    is a DSC curve of Compound 1 crystalline Form I. 
         FIG.  4    is an XRPD pattern of Compound 1 crystalline Form II. 
         FIG.  5    is a TGA plot of Compound 1 crystalline Form II. 
         FIG.  6    is a DSC curve of Compound 1 crystalline Form II. 
         FIG.  7    is an XRPD pattern of Compound 1 crystalline Form III. 
         FIG.  8    is a TGA plot of Compound 1 crystalline Form III. 
         FIG.  9    is a DSC curve of Compound 1 crystalline Form III. 
         FIG.  10    is an XRPD pattern of Compound 1 1,4-dioxane solvate crystalline Form IV. 
         FIG.  11    is a TGA plot of Compound 1 1,4-dioxane solvate crystalline Form IV. 
         FIG.  12    is a DSC curve of Compound 1 1,4-dioxane solvate crystalline Form IV. 
         FIG.  13    is an XRPD pattern of Compound 1 ethyl acetate solvate crystalline form V. 
         FIG.  14    is a TGA plot of Compound 1 ethyl acetate solvate crystalline form V. 
         FIG.  15    is a DSC curve of Compound 1 ethyl acetate solvate crystalline form V. 
         FIG.  16    is an XRPD pattern of Compound 1 methylbenzene solvate crystalline form VI. 
         FIG.  17    is a TGA plot of Compound 1 methylbenzene solvate crystalline form VI. 
         FIG.  18    is a DSC curve of Compound 1 methylbenzene solvate crystalline form VI. 
         FIG.  19    is an XRPD pattern of Compound 1 crystalline Form VII. 
         FIG.  20    is a TGA plot of Compound 1 crystalline Form VII. 
         FIG.  21    is a DSC curve of Compound 1 crystalline Form VII. 
         FIG.  22    is an XRPD pattern of Compound 1 chloroform solvate crystalline form VIII. 
         FIG.  23    is a TGA plot of Compound 1 chloroform solvate crystalline form VIII. 
         FIG.  24    is a DSC curve of Compound 1 chloroform solvate crystalline form VIII. 
         FIG.  25    is an XRPD pattern of Compound 1 methyl tert-butyl ether solvate crystalline form IX. 
         FIG.  26    is a TGA plot of Compound 1 methyl tert-butyl ether solvate crystalline form IX. 
         FIG.  27    is a DSC curve of Compound 1 methyl tert-butyl ether solvate crystalline form IX. 
         FIG.  28    is an XRPD pattern of Compound 1 2-methyltetrahydrofuran solvate crystalline form X. 
         FIG.  29    is a TGA plot of Compound 1 2-methyltetrahydrofuran solvate crystalline form X. 
         FIG.  30    is a DSC curve of Compound 1 2-methyltetrahydrofuran solvate crystalline form X. 
         FIG.  31    is an XRPD pattern of Compound 1 crystalline Form XI. 
         FIG.  32    is a TGA plot of Compound 1 crystalline Form XI. 
         FIG.  33    is a DSC curve of Compound 1 crystalline Form XI. 
         FIG.  34    is an XRPD pattern of Compound 1 acetone solvate crystalline form XII. 
         FIG.  35    is a TGA plot of Compound 1 acetone solvate crystalline form XII. 
         FIG.  36    is a DSC curve of Compound 1 acetone solvate crystalline form XII. 
         FIG.  37    is an XRPD pattern of Compound 1 crystalline Form XIII. 
         FIG.  38    is a TGA plot of Compound 1 crystalline Form XIII. 
         FIG.  39    is a DSC curve of Compound 1 crystalline Form XIII. 
         FIG.  40    is an XRPD pattern of Compound 1 crystalline Form XIV. 
         FIG.  41    is a TGA plot of Compound 1 crystalline Form XIV. 
         FIG.  42    is a DSC curve of Compound 1 crystalline Form XIV. 
         FIG.  43    is an XRPD pattern of Compound 1 crystalline Form XV. 
         FIG.  44    is a TGA plot of Compound 1 crystalline Form XV. 
         FIG.  45    is a DSC curve of Compound 1 crystalline Form XV. 
         FIG.  46    is an XRPD pattern of Compound 1 N,N-dimethylformamide solvate crystalline form XVI. 
         FIG.  47    is a TGA plot of Compound 1 N,N-dimethylformamide solvate crystalline form XVI. 
         FIG.  48    is a DSC curve of Compound 1 N,N-dimethylformamide solvate crystalline form XVI. 
         FIG.  49    is an XRPD pattern of Compound 1 crystalline Form XVII. 
         FIG.  50    is a TGA plot of Compound 1 crystalline Form XVII. 
         FIG.  51    is a DSC curve of Compound 1 crystalline Form XVII. 
         FIG.  52    is an XRPD pattern of Compound 1 crystalline Form XVIII. 
         FIG.  53    is a TGA plot of Compound 1 crystalline Form XVIII  FIG.  54    is a DSC curve of Compound 1 crystalline Form XVIII. 
         FIG.  55    is an XRPD pattern of Compound 1 hydrochloride crystalline form XIX. 
         FIG.  56    is a TGA plot of Compound 1 hydrochloride crystalline form XIX. 
         FIG.  57    is a DSC curve of Compound 1 hydrochloride crystalline form XIX. 
         FIG.  58    is an XRPD pattern of Compound 1 sulphate crystalline form XX. 
         FIG.  59    is a TGA plot of Compound 1 sulphate crystalline form XX. 
         FIG.  60    is a DSC curve of Compound 1 sulphate crystalline form XX. 
         FIG.  61    is an XRPD pattern of Compound 1 mesylate crystalline form XXI. 
         FIG.  62    is a TGA plot of Compound 1 mesylate crystalline form XXI. 
         FIG.  63    is a DSC curve of Compound 1 mesylate crystalline form XXI. 
         FIG.  64    is an XRPD pattern of Compound 1 mesylate crystalline form XXII. 
         FIG.  65    is a TGA plot of Compound 1 mesylate crystalline form XXII. 
         FIG.  66    is a DSC curve of Compound 1 mesylate crystalline form XXII. 
         FIG.  67    is an XRPD pattern of Compound 1 maleate crystalline form XXIII. 
         FIG.  68    is a TGA plot of Compound 1 maleate crystalline form XXIII. 
         FIG.  69    is a DSC curve of Compound 1 maleate crystalline form XXIII. 
         FIG.  70    is an XRPD pattern of Compound 1 maleate crystalline form XXIV. 
         FIG.  71    is a TGA plot of Compound 1 maleate crystalline form XXIV. 
         FIG.  72    is a DSC curve of Compound 1 maleate crystalline form XXIV. 
         FIG.  73    is an XRPD pattern of Compound 1 amorphous form XXV. 
         FIG.  74    is a TGA plot of Compound 1 amorphous form XXV. 
         FIG.  75    is a DSC curve of Compound 1 amorphous form XXV. 
         FIG.  76    is an XRPD pattern of Compound 1 acetone solvate crystalline form XXVI. 
         FIG.  77    is a TGA plot of Compound 1 acetone solvate crystalline form XXVI. 
         FIG.  78    is a DSC curve of Compound 1 acetone solvate crystalline form XXVI. 
         FIG.  79    is an XRPD pattern of Compound 1 benzene sulfonate crystalline Form XXVII. 
         FIG.  80    is a TGA plot of Compound 1 benzene sulfonate crystalline Form XXVII. 
         FIG.  81    is a DSC curve of Compound 1 benzene sulfonate crystalline Form XXVII. 
         FIG.  82    is an XRPD pattern of Compound 1 p-toluenesulfonate crystalline Form XXVIII. 
         FIG.  83    is a TGA plot of Compound 1 p-toluenesulfonate crystalline Form XXVIII. 
         FIG.  84    is a DSC curve of Compound 1 p-toluenesulfonate crystalline Form XXVIII. 
         FIG.  85    is an XRPD pattern of Compound 1 p-toluenesulfonate crystalline Form XXIX. 
         FIG.  86    is a TGA plot of Compound 1 p-toluenesulfonate crystalline Form XXIX. 
         FIG.  87    is a DSC curve of Compound 1 p-toluenesulfonate crystalline Form XXIX. 
         FIG.  88    is an XRPD pattern of Compound 1 sulphate crystalline Form XXX. 
         FIG.  89    is a TGA plot of Compound 1 sulphate crystalline Form XXX. 
         FIG.  90    is a DSC curve of Compound 1 sulphate crystalline Form XXX. 
         FIG.  91    is an XRPD pattern of Compound 1 sulphate crystalline Form XXXI. 
         FIG.  92    is a TGA plot of Compound 1 sulphate crystalline Form XXXI. 
         FIG.  93    is a DSC curve of Compound 1 sulphate crystalline Form XXXI. 
         FIG.  94    is an XRPD pattern of Compound 1 sulphate crystalline Form XXXII. 
         FIG.  95    is a TGA plot of Compound 1 sulphate crystalline Form XXXII. 
         FIG.  96    is a DSC curve of Compound 1 sulphate crystalline Form XXXII. 
         FIG.  97    is an XRPD pattern of Compound 1 mesylate crystalline Form XXXIII. 
         FIG.  98    is a TGA plot of Compound 1 mesylate crystalline Form XXXIII. 
         FIG.  99    is a DSC curve of Compound 1 mesylate crystalline Form XXXIII. 
         FIG.  100    is an XRPD pattern of Compound 1 mesylate crystalline Form XXXIV. 
         FIG.  101    is a TGA plot of Compound 1 mesylate crystalline Form XXXIV. 
         FIG.  102    is a DSC curve of Compound 1 mesylate crystalline Form XXXIV. 
         FIG.  103    is an XRPD pattern of Compound 1 mesylate crystalline Form XXXV. 
         FIG.  104    is a TGA plot of Compound 1 mesylate crystalline Form XXXV. 
         FIG.  105    is a DSC curve of Compound 1 mesylate crystalline Form XXXV. 
         FIG.  106    is an XRPD pattern of Compound 1 citrate crystalline Form XXXVI. 
         FIG.  107    is a TGA plot of Compound 1 citrate crystalline Form XXXVI. 
         FIG.  108    is a DSC curve of Compound 1 citrate crystalline Form XXXVI. 
         FIG.  109    is an XRPD pattern of Compound 1 citrate crystalline Form XXXVII. 
         FIG.  110    is a TGA plot of Compound 1 citrate crystalline Form XXXVII. 
         FIG.  111    is a DSC curve of Compound 1 citrate crystalline Form XXXVII. 
         FIG.  112    is an XRPD pattern of Compound 1 citrate crystalline Form XXXVIII. 
         FIG.  113    is a TGA plot of Compound 1 citrate crystalline Form XXXVIII. 
         FIG.  114    is a DSC curve of Compound 1 citrate crystalline Form XXXVIII. 
         FIG.  115    is an XRPD pattern of Compound 1 citrate crystalline Form XXXIX. 
         FIG.  116    is a TGA plot of Compound 1 citrate crystalline Form XXXIX. 
         FIG.  117    is a DSC curve of Compound 1 citrate crystalline Form XXXIX. 
         FIG.  118    is an XRPD pattern of Compound 1 maleate crystalline Form XL. 
         FIG.  119    is a TGA plot of Compound 1 maleate crystalline Form XL. 
         FIG.  120    is a DSC curve of Compound 1 maleate crystalline Form XL. 
         FIG.  121    is an XRPD pattern of Compound 1 maleate crystalline Form XLI. 
         FIG.  122    is a TGA plot of Compound 1 maleate crystalline Form XLI. 
         FIG.  123    is a DSC curve of Compound 1 maleate crystalline Form XLI. 
         FIG.  124    is an XRPD pattern of Compound 1 maleate crystalline Form XLII. 
         FIG.  125    is a TGA plot of Compound 1 maleate crystalline Form XLII. 
         FIG.  126    is a DSC curve of Compound 1 maleate crystalline Form XLII. 
         FIG.  127    is an XRPD pattern of Compound 1 maleate crystalline Form XLIII. 
         FIG.  128    is a TGA plot of Compound 1 maleate crystalline Form XLIII. 
         FIG.  129    is a DSC curve of Compound 1 maleate crystalline Form XLIII. 
         FIG.  130    is an XRPD pattern of Compound 1 maleate crystalline Form XLIV. 
         FIG.  131    is a TGA plot of Compound 1 maleate crystalline Form XLIV. 
         FIG.  132    is a DSC curve of Compound 1 maleate crystalline Form XLIV. 
         FIG.  133    is an XRPD pattern of Compound 1 tartrate crystalline Form XLV. 
         FIG.  134    is a TGA plot of Compound 1 tartrate crystalline Form XLV. 
         FIG.  135    is a DSC curve of Compound 1 tartrate crystalline Form XLV. 
         FIG.  136    is an XRPD pattern of Compound 1 hydrochloride crystalline Form XLVI. 
         FIG.  137    is a TGA plot of Compound 1 hydrochloride crystalline Form XLVI. 
         FIG.  138    is a DSC curve of Compound 1 hydrochloride crystalline Form XLVI. 
         FIG.  139    is an XRPD pattern of Compound 1 hydrochloride crystalline Form XLVII. 
         FIG.  140    is a TGA plot of Compound 1 hydrochloride crystalline Form XLVII. 
         FIG.  141    is a DSC curve of Compound 1 hydrochloride crystalline Form XLVII. 
         FIG.  142    is an XRPD pattern of Compound 1 hydrochloride crystalline Form XLVIII. 
         FIG.  143    is a TGA plot of Compound 1 hydrochloride crystalline Form XLVIII. 
         FIG.  144    is a DSC curve of Compound 1 hydrochloride crystalline Form XLVIII. 
         FIG.  145    is an XRPD pattern of Compound 1 hydrochloride crystalline Form XLIX. 
         FIG.  146    is a TGA plot of Compound 1 hydrochloride crystalline Form XLIX. 
         FIG.  147    is a DSC curve of Compound 1 hydrochloride crystalline Form XLIX. 
         FIG.  148    is an XRPD pattern of Compound 1 hydrochloride crystalline Form L. 
         FIG.  149    is a TGA plot of Compound 1 hydrochloride crystalline Form L. 
         FIG.  150    is a DSC curve of Compound 1 hydrochloride crystalline Form L. 
         FIG.  151    is an XRPD pattern of Compound 1 hydrochloride crystalline Form LI. 
         FIG.  152    is a TGA plot of Compound 1 hydrochloride crystalline Form LI. 
         FIG.  153    is a DSC curve of Compound 1 hydrochloride crystalline Form LI. 
         FIG.  154    is an XRPD pattern of Compound 1 hydrochloride crystalline Form LII. 
         FIG.  155    is a TGA plot of Compound 1 hydrochloride crystalline Form LII. 
         FIG.  156    is a DSC curve of Compound 1 hydrochloride crystalline Form LII. 
         FIG.  157    is an XRPD pattern of Compound 1 hydrochloride crystalline Form LIII. 
         FIG.  158    is a TGA plot of Compound 1 hydrochloride crystalline Form LIII. 
         FIG.  159    is a DSC curve of Compound 1 hydrochloride crystalline Form LIII. 
         FIG.  160    is an XRPD pattern of Compound 1 hydrochloride crystalline Form LIV. 
         FIG.  161    is a TGA plot of Compound 1 hydrochloride crystalline Form LIV. 
         FIG.  162    is a DSC curve of Compound 1 hydrochloride crystalline Form LIV. 
         FIG.  163    is an XRPD pattern of Compound 1 hydrochloride crystalline Form LV. 
         FIG.  164    is a TGA plot of Compound 1 hydrochloride crystalline Form LV. 
         FIG.  165    is a DSC curve of Compound 1 hydrochloride crystalline Form LV. 
         FIG.  166    is a DVS figure of Compound 1 crystalline Form III. 
         FIG.  167    is a comparison diagram of XRPD pattern of Compound 1 crystalline Form III before DVS test and after DVS test. 
         FIG.  168    is a DVS figure of Compound 1 crystalline Form XVIII  FIG.  169    is a comparison diagram of XRPD pattern of Compound 1 crystalline Form XVIII before DVS test and after DVS test. 
         FIG.  170    is a DVS figure of Compound 1 benzene sulfonate crystalline Form XXVII  FIG.  171    is a DVS figure of Compound 1 p-toluenesulfonate crystalline Form XXIX. 
         FIG.  172    is a DVS figure of Compound 1 sulphate crystalline Form XXX. 
         FIG.  173    is a DVS figure of Compound 1 citrate crystalline Form XXXIX. 
         FIG.  174    is a DVS figure of Compound 1 citrate crystalline Form XXXVI. 
         FIG.  175    is a DVS figure of Compound 1 maleate crystalline Form XL. 
         FIG.  176    is a DVS figure of Compound 1 maleate crystalline Form XXIV. 
         FIG.  177    is a DVS figure of Compound 1 mesylate crystalline Form XXXIII. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     Examples 
     In the following examples, the experimental methods are completed in accordance with conventional conditions or conventional test conditions, and the compounds used in the examples are commercially available or self-made. 
     Example 1: Preparation of Crystalline Form I of Compound 1 
     200 mg of compound 1 was weighed and placed in a 5 mL vial, added with 4 mL mixed solvent THF/H2O (1:9, V/V), stirred for 5 days at room temperature, centrifuged for separation that solids were dried at room temperature to obtain the crystalline form I. 
     Example 2: Preparation of Crystalline Form II of Compound 1 
     200 mg of compound 1 was weighed and placed in a 5 mL vial, added with 4 mL ethyl acetate, heated to reflux, cooled, separated that solids were dried at room temperature to obtain the crystalline form II. 
     Example 3: Preparation of Crystalline Form III of Compound 1 
     200 mg of compound 1 was weighed and placed in a 5 mL vial, added with 4 mL EtOAc, stirred for 5 days at 70° C., centrifuged for separation that solids were dried at room temperature to obtain the crystalline form III. 
     Example 4: Preparation of 1,4-Dioxane Solvate Crystalline Form IV of Compound 1 
     50 mg of compound 1 was weighed and placed in a 3 mL vial which was placed in a 20 mL vial containing 3 mL of solvent 1, 4-dioxane. The sample was allowed to stand at room temperature for 3 days, centrifuged for separation that solids were dried at room temperature to obtain the 1,4-dioxane solvate crystalline Form IV. 
     Example 5: Preparation of Ethyl Acetate Solvate Crystalline Form V of Compound 1 
     50 mg of compound 1 was weighed and placed in a HPLC vial, added with 1 mL EtOAc, stirred at room temperature for 8 days, centrifuged for separation that solids were dried at room temperature to obtain the ethyl acetate solvate crystalline form V. 
     Example 6: Preparation of Methylbenzene Solvate Crystalline Form VI of Compound 1 
     50 mg of compound 1 was weighed and placed in a 3 mL vial, added with 1 mL methylbenzene, stirred at room temperature for 22 hours, centrifuged for separation that solids were dried at room temperature to obtain the methylbenzene solvate crystalline form VI. 
     Example 7: Preparation of Crystalline Form VII of Compound 1 
     200 mg of compound 1 was weighed and placed in a 3 mL vial, added with 4.0 mL EtOH, stirred at room temperature for 5 days, centrifuged for separation that solids were dried at room temperature to obtain the crystalline Form VII. 
     Example 8: Preparation of Chloroform Solvate Crystalline Form VIII of Compound 1 
     15 mg of compound 1 was weighed and placed in a 3 mL vial, added with 0.5 mL CHCl3 for dissolved clarification of solids. The 3 mL vial was placed in a 20 mL vial containing 3 mL of solvent n-heptane. The sample was allowed to stand at room temperature for 1 day, centrifuged for separation that solids were dried at room temperature to obtain the chloroform solvate crystalline form VIII. 
     Example 9: Preparation of Methyl Tert-Butyl Ether Solvate Crystalline Form IX of Compound 1 
     50 mg of compound 1 was weighed and placed in a HPLC vial, added with 1.0 mL MTBE, stirred at room temperature for 6 days, centrifuged for separation that solids were dried at room temperature to obtain the methyl tert-butyl ether solvate crystalline form IX. 
     Example 10: Preparation of 2-Methyltetrahydrofuran Solvate Crystalline Form X of Compound 1 
     40 mg of compound 1 was weighed and placed in a HPLC vial, added with 0.8 mL solvent 2-MeTHF, stirred at room temperature for 1 hour, centrifuged for separation that solids were dried at room temperature to obtain the 2-methyltetrahydrofuran solvate crystalline form X. 
     Example 11: Preparation of Crystalline Form XI of Compound 1 
     16 mg of compound 1 was weighed and placed in a HPLC vial, added with 0.5 mL ACN, stirred at room temperature for 5 days, centrifuged for separation that solids were dried at room temperature to obtain the crystalline Form XI. 
     Example 12: Preparation of Acetone Solvate Crystalline Form XII of Compound 1 
     11 mg of crystalline Form VII was weighed and placed in a HPLC vial, added with 1.0 mL solvent acetone, stirred at room temperature for 1.5 hours, centrifuged for separation that solids were dried at room temperature to obtain the acetone solvate crystalline form XII. 
     Example 13: Preparation of Crystalline Form XIII of Compound 1 
     50 mg of compound 1 was weighed and placed in a 20 mL vial, added with 6 mL solvent acetone for dissolved clarification of solids, 5.0 ml anti-solvent H 2 O was added dropwise while stirring at room temperature, solid precipitated, continue to stir at room temperature for 4 days centrifuged for separation that solids were dried at room temperature to obtain the crystalline Form XIII. 
     Example 14: Preparation of Crystalline Form XIV of Compound 1 
     15 mg of compound 1 was weighed and placed in a 20 mL vial, added with 0.4 mL solvent DCM for dissolved clarification of solids, 15.0 mL of anti-solvent toluene was added dropwise while stirring at room temperature. The sample was clear. After stirring at 5° C., no solid precipitated. 
     The sample was transfered to room temperature for open volatilization, centrifuged for separation that solids were dried at room temperature to obtain the crystalline Form XIV. 
     Example 15: Preparation of Crystalline Form XV of Compound 1 
     50 mg of compound 1 was weighed and placed in a 3 mL vial which was placed in a 20 mL vial containing 3 mL of solvent EtOH. The sample was allowed to stand at room temperature for 5 days, centrifuged for separation that solids were dried at room temperature to obtain the crystalline Form XV. 
     Example 16: Preparation of N,N-Dimethylformamide Solvate Crystalline Form XVI of Compound 1 
     50 mg of compound 1 was weighed and placed in a 3 mL vial which was placed in a 20 mL vial containing 3 mL of solvent DMF. The sample was allowed to stand at room temperature for 5 days, centrifuged for separation that solids were dried at room temperature to obtain the N,N-dimethylformamide solvate crystalline form XVI. 
     Example 17: Preparation of Crystalline Form XVII of Compound 1 
     15 mg of compound 1 was weighed and placed in a 3 mL vial, added with 0.5 mL solvent THF for dissolved clarification of solids. The 3 mL vial was placed in a 20 mL vial containing 3 mL of solvent EtOH. The sample was allowed to stand at room temperature for 2 days, centrifuged for separation that solids were dried at room temperature to obtain the crystalline Form XVII. 
     Example 18: Preparation of Crystalline Form XVIII of Compound 1 
     The crystalline Form IV of Compound 1 was heated to 150° C. and cooled down to room temperature to obtain the crystalline Form XVIII. 
     Example 19: Preparation of Hydrochloride Crystalline Form XIX of Compound 1 
     16 mg of Compound 1 was weighed and placed in a HPLC vial, added with 0.5 mL solvent EtOH, added with 34.0 μL 1M hydrochloric acid, stirred at room temperature for 4 days, centrifuged for separation that solids were dried at room temperature to obtain the hydrochloride crystalline form XIX. 
     Example 20: Preparation of Sulphate Crystalline Form XX of Compound 1 
     15 mg of Compound 1 was weighed and placed in a HPLC vial, added with 0.5 mL solvent EtOH, added with 17.0 μL 1M sulfuric acid, stirred at room temperature for 4 days, centrifuged for separation that solids were dried at room temperature to obtain the sulphate crystalline form XX. 
     Example 21: Preparation of the Mesylate Crystalline Form XXI of Compound 1 
     1.7 mg of mesylate was weighed and placed in a HPLC vial, added with 0.5 mL solvent EtOAc, added with 15 mg of Compound 1, stirred at room temperature for 4 days, centrifuged for separation that solids were dried at room temperature to obtain the mesylate crystalline form XXI. 
     Example 22: Preparation of the Mesylate Crystalline Form XXII of Compound 1 
     1.7 mg of mesylate was weighed and placed in a HPLC vial, added with 0.5 mL solvent EtOH, added with 15 mg of Compound 1, stirred at room temperature for 4 days, centrifuged for separation that solids were dried at room temperature to obtain the mesylate crystalline form XXII. 
     Example 23: Preparation of the Maleate Crystalline Form XXIII of Compound 1 
     15 mg of Compound 1 and 2.0 mg of maleic acid was weighed and placed in a HPLC vial, added with 0.5 mL solvent EtOAc, stirred at room temperature for 4 days, centrifuged for separation that solids were dried at room temperature to obtain the maleate crystalline form XXIII. 
     Example 24: Preparation of the Maleate Crystalline Form XXIV of Compound 1 
     15 mg of Compound 1 and 2.2 mg of maleic acid was weighed and placed in a HPLC vial, added with 0.5 mL solvent EtOH, stirred at room temperature for 4 days, centrifuged for separation that solids were dried at room temperature to obtain the maleate crystalline form XXIV. 
     Example 25: Preparation of the Amorphous Form XXV of Compound 1 
     6 g of Compound 1 was added in a 250 mL bottle, added with 200 mL solvent DCM for dissolved clarification of solids. The solution was spray dried for about 30 minutes and the injection temperature was 90° C. to obtain the amorphous form of the compound 1. 
     Example 26: Preparation of the Acetone Solvate Crystalline Form XXVI of Compound 1 
     About 40 mg of the sample (crystalline form XVIII) was weighed and placed in a 4 mL glass bottle. Then 0.4 mL acetone was gradually added into the glass bottle to make a turbid sample. After adding magnetons, the sample was stirred (40° C., 600 rpm). After stirring over the weekend, the sample was still turbid. After the sample was centrifuged, the residual solids were dried in a vacuum drying oven at 25° C. to obtain the acetone solvate crystalline form XXVI. 
     Example 27: Preparation of the Compound 1 Benzene Sulfonate Crystalline Form XXVII 
     The sample (crystalline form XVIII) was accurately weighed about 1058.9 mg, and placed in a 20 mL glass bottle. Then 6 mL DCM and 12 mL THF were added to dissolve and heated to help dissolve. After adding with magnetons, the sample was placed on a stirrer for stirring. Then phenylsulfonic acid was added in the amount that the molar ratio of API to acid was 1:1 (the acid was first dissolved with 1.5 mL EtOH), stirred overnight at room temperature, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 benzene sulfonate crystalline form XXVII. 
     Example 28: Preparation of the Compound 1 p-Toluenesulfonate Crystalline Form XXVIII 
     The sample (crystalline form XVIII) was accurately weighed about 1058.9 mg, and placed in a 20 mL glass bottle. Then 6 mL DCM and 12 mL THF were added to dissolve and heated to help dissolve. After adding with magnetons, the sample was placed on a stirrer for stirring. Then p-toluenesulfonic acid was added in the amount that the molar ratio of API to acid was 1:1 (the acid was first dissolved with 1.5 mL EtOH), stirred overnight at room temperature, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 p-toluenesulfonate crystalline form XXVIII. 
     Example 29: Preparation of the Compound 1 p-Toluenesulfonate Crystalline Form XXIX 
     The sample (Compound 1 p-toluenesulfonate crystalline form XXVIII) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL single or mixed solvents (methanol, acetonitrile, acetone, ethyl acetate, methanol:water 3:1 (v:v), ethanol:water 3:1 (v:v), acetonitrile:water 1:1 (v:v) or acetone:water 1:2 (v:v)) into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 p-toluenesulfonate crystalline form XXIX. 
     Example 30: Preparation of the Compound 1 Sulphate Crystalline Form XXX 
     The sample (crystalline form XVIII) was accurately weighed about 1058.9 mg, and placed in a 20 mL glass bottle. Then 6 mL DCM and 12 mL THF were added to dissolve and heated to help dissolve. After adding with magnetons, the sample was placed on a stirrer for stirring. Then sulfuric acid was added in the amount that the molar ratio of API to acid was 1:1 (the sulfuric acid was diluted with THF 10 times before use), stirred overnight at room temperature, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 sulphate crystalline form XXX. 
     Example 31: Preparation of the Compound 1 Sulphate Crystalline Form XXXI 
     The sample (sulphate crystalline form XXX) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL ethyl acetate into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 sulphate crystalline form XXXI. 
     Example 32: Preparation of the Compound 1 Sulphate Crystalline Form XXXII 
     The sample (sulphate crystalline form XXX) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL acetonitrile-water (v:v 1:1) into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 sulphate crystalline form XXXII. 
     Example 33: Preparation of the Compound 1 Mesylate Crystalline Form XXXIII 
     The sample (crystalline form XVIII) was accurately weighed about 1058.9 mg, and placed in a 20 mL glass bottle. Then 6 mL DCM and 12 mL THF were added to dissolve and heated to help dissolve. After adding with magnetons, the sample was placed on a stirrer for stirring. Then methanesulfonic acid was added in the amount that the molar ratio of API to acid was 1:1 (the methanesulfoni acid was diluted with THF times before use), stirred overnight at room temperature, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 mesylate crystalline form XXXIII. 
     Example 34: Preparation of the Compound 1 Mesylate Crystalline Form XXXIV 
     The sample (mesylate crystalline form XXXII) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL methanol into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 mesylate crystalline form XXXIV. 
     Example 35: Preparation of the Compound 1 Mesylate Crystalline Form XXXV 
     The sample (mesylate crystalline form XXXII) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL 1,4-dioxane into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 mesylate crystalline form XXXV. 
     Example 36: Preparation of the Compound 1 Citrate Crystalline Form XXXVI 
     The sample (crystalline form XVIII) was accurately weighed about 1058.9 mg, and placed in a 20 mL glass bottle. Then 6 mL DCM and 12 mL THF were added to dissolve and heated to help dissolve. After adding with magnetons, the sample was placed on a stirrer for stirring. Then citric acid was added in the amount that the molar ratio of API to acid was 1:1, stirred overnight at room temperature, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 citrate crystalline form XXXVI. 
     Example 37: Preparation of the Compound 1 Citrate Crystalline Form XXXVII 
     The sample (XXXVI) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL methanol or ethanol into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 citrate crystalline form XXXVII. 
     Example 38: Preparation of the Compound 1 Citrate Crystalline Form XXXVIII 
     The sample (XXXVI) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL acetonitrile into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 citrate crystalline form XXXVIII. 
     Example 39: Preparation of the Compound 1 Citrate Crystalline Form XXXIX 
     The sample (XXXVI) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL tetrahydrofuran or 1, 4-dioxane into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 citrate crystalline form XXXIX. 
     Example 40: Preparation of the Compound 1 Maleate Crystalline Form XL 
     The sample (crystalline form XVIII) was accurately weighed about 1058.9 mg, and placed in a 20 mL glass bottle. Then 6 mL DCM and 12 mL THF were added to dissolve and heated to help dissolve. After adding with magnetons, the sample was placed on a stirrer for stirring. Then maleic acid was added in the amount that the molar ratio of API to acid was 1:1, stirred overnight at room temperature, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 maleate crystalline form XL. 
     Example 41: Preparation of the Compound 1 Maleate Crystalline form XLI 
     The sample (XL) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL acetonitrile or acetonitrile-water (v:v 1:1) into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 maleate crystalline form XLI. 
     Example 42: Preparation of the Compound 1 Maleate Crystalline Form XLII 
     The sample (XL) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL n-heptane into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 maleate crystalline form XLII. 
     Example 43: Preparation of the Compound 1 Maleate Crystalline Form XLIII 
     The sample (XL) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL 1,4-dioxane into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 maleate crystalline form XLIII. 
     Example 44: Preparation of the Compound 1 Maleate Crystalline Form XLIV 
     The sample (XL) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL water into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 maleate crystalline form XLIV. 
     Example 45: Preparation of the Compound 1 Tartrate Crystalline Form XLV 
     The crystalline form XVIII was accurately weighed about 1058.9 mg, and placed in a 20 mL glass bottle. Then 6 mL DCM and 12 mL THF were added to dissolve and heated to help dissolve. After adding with magnetons, the sample was placed on a stirrer for stirring. Then tartaric acid was added in the amount that the molar ratio of API to acid was 1:1, stirred overnight at room temperature, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 tartrate crystalline form XLV. 
     Example 46: Preparation of the Compound 1 Hydrochloride Crystalline Form XLVI 
     The crystalline form XVIII was accurately weighed about 176.5 mg, and placed in a 4 mL glass bottle. Then 1 mL DCM and 2 mL THF were added to dissolve and heated to help dissolve. After adding with magnetons, the sample was placed on a stirrer for stirring. Then hydrochloric acid was added in the amount that the molar ratio of API to acid was 1:1 (the hydrochloric acid was diluted with THF 10 times before use), stirred overnight at room temperature, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 hydrochloride crystalline form XLVI. 
     Example 47: Preparation of the Compound 1 Hydrochloride Crystalline Form XLVII 
     The crystalline form XVIII was accurately weighed about 1058.9 mg, and placed in a 20 mL glass bottle. Then 6 mL DCM and 12 mL THF were added to dissolve and heated to help dissolve. After adding with magnetons, the sample was placed on a stirrer for stirring. Then hydrochloric acid was added in the amount that the molar ratio of API to acid was 1:1 (the hydrochloric acid was diluted with THF 10 times before use), stirred overnight at room temperature, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 hydrochloride crystalline form XLVII. 
     Example 48: Preparation of the Compound 1 Hydrochloride Crystalline Form XLVIII 
     The sample (XLVII) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL methyl alcohol into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 hydrochloride crystalline form XLVIII. 
     Example 49: Preparation of the Compound 1 Hydrochloride Crystalline Form XLIX 
     The sample (XLVII) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL ethanol or n-heptane into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 hydrochloride crystalline form XLIX. 
     Example 50: Preparation of the Compound 1 Hydrochloride Crystalline Form L 
     The sample (XLVII) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL acetonitrile into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 hydrochloride crystalline form L. 
     Example 51: Preparation of the Compound 1 Hydrochloride Crystalline Form LI 
     The sample (XLVII) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL acetone (or acetone-water 1:2, ethanol-water 3:1) into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 hydrochloride crystalline form LI. 
     Example 52: Preparation of the Compound 1 Hydrochloride Crystalline Form LII 
     The sample (XLVII) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL ethyl acetate into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 hydrochloride crystalline form LII. 
     Example 53: Preparation of the Compound 1 Hydrochloride Crystalline Form LIII 
     The sample (XLVII) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL 1,4-dioxane into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 hydrochloride crystalline form LIII. 
     Example 54: Preparation of the Compound 1 Hydrochloride Crystalline Form LIV 
     The sample (XLVII) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL water into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound 1 hydrochloride crystalline form LIV. 
     Example 55: Preparation of the Compound 1 Hydrochloride Crystalline Form LV 
     The sample (XLVII) was accurately weighed about 40 mg, and placed in a 4 mL glass bottle, gradually added with 0.4 mL methanol-water 3:1 into the glass bottle to get suspension sample. After adding with magnetons, the suspension sample was stirred at 40° C. for 3 days, centrifuged, and the residual solids were dried in a vacuum drying oven at 25° C. to obtain the Compound hydrochloride crystalline form LV. 
     Example 56: Identification and Characterization of Compound 1 Form I-LV and DVS Test of Compound 1 
     The used instruments and their parameters are described as follows: 
     1. XRPD X-Ray Powder Diffraction 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 55 
               
               
                   
               
               
                   
                 Kα1 (Å): 1.540598, 
                 Kα1 (Å): 1.540598, 
                 Kα1 (Å): 1.5406 
                   
               
               
                   
                 Kα2 (Å): 1.544426 
                 Kα2 (Å): 1.544426 
                 Kα2 (Å): 1.54439 
               
               
                 X rays 
                 Kα2/Kα1 
                 Kα2/Kα1 
                 Kα2/Kα1 
               
               
                 Cu, Kα, 
                 intensity ratio: 0.50 
                 intensity ratio: 0.50 
                 intensity ratio: 0.50 
                 Kα(Å): 1.5406 
               
               
                   
               
             
            
               
                 Setting of X-ray tube 
                 45 kV, 40 mA 
                 45 kV, 40 mA 
                 30 kV, 10 mA 
                 40 KV, 40 mA 
               
               
                 Divergence slit 
                 Auto 
                 ⅛° 
                 0.6 mm 
                 1.0 mm 
               
               
                 Scanning range 
                 3°-40° 
                 3°-40° 
                 3°-40° 
                 3°-40° 
               
               
                 (°2Theta) 
               
               
                 Scanning time per 
                 17.8 
                 46.7 
                 0.1 
                 0.1 
               
               
                 step (s) 
               
               
                 Scanning step size 
                 0.0167 
                 0.0263 
                 0.0201 
                 0.02 
               
               
                 (°2Theta) 
               
               
                   
               
            
           
         
       
     
     2. TGA—Thermogravimetric Analysis and DSC—Differential Scanning Calorimetry 
     
       
         
           
               
               
               
             
               
                 TABLE 56-1 
               
               
                   
               
               
                 Parameter 
                 TA Instruments TGA 
                 TA Instruments DSC 
               
               
                   
               
             
            
               
                 Method 
                 Linear temperature 
                 Linear temperature 
               
               
                 Sample plate 
                 Platinum plate, open 
                 Aluminum plate, 
               
               
                   
                   
                 Gland/Ungland 
               
               
                 Temperature range 
                 Room temperature-set the 
                 25° C. - set the end 
               
               
                   
                 end temperature 
                 temperature 
               
               
                 Scanning rate (° C./ 
                 10 
                 10 
               
               
                 min) 
               
               
                 Shielding gas 
                 Nitrogen 
                 Nitrogen 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 56-2 
               
             
            
               
                   
               
               
                 mDSC 
               
            
           
           
               
               
               
            
               
                   
                 Parameter 
                 Set value 
               
               
                   
                   
               
               
                   
                 Test mode 
                 Conventional mDSC 
               
               
                   
                 Amplitude (° C.) 
                 1.0 
               
               
                   
                 Modulation period (sec.) 
                 60 
               
               
                   
                 Scanning rate (° C./Minute) 
                 3.0 
               
               
                   
                 Shielding gas 
                 Nitrogen 
               
               
                   
                   
               
            
           
         
       
     
     3. DVS 
     
       
         
           
               
               
             
               
                 TABLE 57 
               
               
                   
               
               
                 Parameter 
                 Set value 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 Temperature 
                 25° 
                 C. 
               
               
                 Amount of sample 
                 10-20 
                 mg 
               
            
           
           
               
               
            
               
                 Shielding gas and rate of flow 
                 N 2 , 200 ml/minute 
               
               
                 dm/dt 
                 0.002%/minute 
               
            
           
           
               
               
               
            
               
                 Minimum equilibrium time 
                 10 
                 minute 
               
               
                 Maximum equilibrium time 
                 180 
                 minute 
               
            
           
           
               
               
            
               
                 RH range 
                 0% RH-90% RH-0% RH 
               
               
                 RH gradient 
                 10%(0% RH-90% RH, 90% RH-0% RH) 
               
               
                   
                 5%(90% RH-95% RH, 95% RH-90% RH) 
               
               
                   
               
            
           
         
       
     
     Example 57: Anti-Solvent Method was Used to Prepare Forms of Compound 1 
     15 mg of Compound 1 was weighed into a 20 mL vial, and added with 0.4-2.0 mL of solvent to completely dissolve the solids. Anti-solvent was added dropwise to the clarifying solution while stirring until solids were precipitated, or when the total volume of anti-solvent was increased to 15 mL, the sample without solid precipitation was suspended and stirred at 5° C. for 20 hours. If there was still no solid precipitation, the sample was evaporated at room temperature, and the precipitated solids were separated and XRPD test was performed. The related results are shown in Table 58 below. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 58 
               
               
                   
               
               
                 No. 
                 Solvent 
                 Anti-solvent 
                 Solid Form 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 1 
                 THF 
                 Water 
                 Crystalline Form XVII 
               
               
                 2 
                   
                 n-Heptane 
                 Crystalline Form XVII 
               
               
                 3 
                   
                 Methanol 
                 Crystalline Form VII 
               
               
                 4 
                   
                 Methyl tert-butyl ether 
                 Amorphous Form 
               
               
                 5 
                 Acetone 
                 Ethyl Alcohol 
                 Crystalline Form XVII 
               
               
                 6 
                   
                 n-Heptane 
                 Crystalline Form XVII 
               
               
                 7 
                   
                 Water 
                 Crystalline Form XIII 
               
               
                 8 
                 1,4-dioxane 
                 Isopropanol 
                 Crystalline Form XVII 
               
               
                 9 
                   
                 Isopropyl Acetate 
                 Crystalline Form I 
               
               
                 10 
                   
                 Methyl tert-butyl ether 
                 Crystalline Form VII 
               
               
                 11 
                   
                 Water 
                 Crystalline Form IV 
               
               
                   
               
            
           
         
       
     
     Example 58: Slow Evaporation Method was Used to Prepare Forms of Compound 1 
     15 mg of Compound 1 was weighed into a 3 mL vial, and added with 0.5-3.0 mL of solvent to dissolve respectively (the undissolved sample was filtered by 0.45 μm PTFE filter head). The vial was sealed with the Parafilm® sealing film, poked 4 pinholes in the top, and evaporated slowly at room temperature, and the solids were collected and XRPD test was performed. The related results are shown in Table 59 below. 
     
       
         
           
               
               
               
             
               
                 TABLE 59 
               
               
                   
               
               
                 No. 
                 Solvent 
                 Solid Form 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 1 
                 Acetone 
                 Crystalline Form I + 
               
               
                   
                   
                 Crystalline Form XVII 
               
               
                 2 
                 THF 
                 Crystalline Form X 
               
               
                 3 
                 1,4-Dioxane 
                 Crystalline Form IV 
               
               
                 4 
                 Dichloromethane 
                 Crystalline Form V 
               
               
                 5 
                 Ethyl acetate 
                 Crystalline Form V 
               
               
                 6 
                 2-Methyltetrahydrofuran/ 
                 Crystalline Form IX 
               
               
                   
                 Methyl tert-butyl ether (1:1) 
               
               
                 7 
                 Dichloromethane/Heptane (1:1) 
                 Crystalline Form XVII 
               
               
                 8 
                 THF/Methanol (1:1) 
                 Crystalline Form VII 
               
               
                   
               
            
           
         
       
     
     Example 59: Gas-Liquid Diffusion Method was Used to Prepare Forms of Compound 1 
     15 mg of Compound 1 was weighed into a 3 mL vial, and added with 0.5-2.0 mL of solvent to dissolve (the undissolved sample was filtered by 0.45 μm PTFE filter head). Another 20 mL bottle was taken to add with 3 mL of anti-solvent. The 3 mL open vial containing the clear liquid was put into the 20 mL bottle. The 20 mL bottle was sealed and standed at room temperature for 1-7 days, and the solids were collected and XRPD test was performed. The related results are shown in Table 60 below. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 60 
               
               
                   
               
               
                 No. 
                 Solvent 
                 Anti-solvent 
                 Solid Form 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 1 
                 THF 
                 Ethyl Alcohol 
                 Crystalline Form XVII 
               
               
                 2 
                   
                 Water 
                 Crystalline Form XVII 
               
               
                 3 
                   
                 Methyl tert-butyl ether 
                 Crystalline Form XVII 
               
               
                 4 
                 2-Methyl- 
                 n-Heptane 
                 Crystalline Form XVII 
               
               
                 5 
                 tetrahydrofuran 
                 Methyl tert-butyl ether 
                 Crystalline Form XVII 
               
               
                 6 
                 1,4-Dioxane 
                 Isopropanol 
                 Crystalline Form IV 
               
               
                 7 
                   
                 n-Heptane 
                 Crystalline Form IV 
               
               
                 8 
                   
                 Isopropyl Acetate 
                 Crystalline Form IV 
               
               
                 9 
                 Acetone 
                 Toluene 
                 Crystalline Form II and 
               
               
                   
                   
                   
                 Crystalline Form XVII 
               
               
                 10 
                 Trichloro- 
                 n-Heptane 
                 Crystalline Form VIII 
               
               
                 11 
                 methane 
                 Methanol 
                 Crystalline Form VIII 
               
               
                 12 
                   
                 Acetonitrile 
                 Crystalline Form VIII 
               
               
                   
               
            
           
         
       
     
     Example 60: Suspension Stirring Method at Room Temperature was Used to Prepare Forms of Compound 1 
     15 mg of Compound 1 was weighed into a 1.5 mL glass vial, and added with 0.5 mL of solvent respectively to get turbid liquid, and standed at room temperature under magnetic stirring for 5 days, and the centrifugal solids were collected and XRPD test was performed. The related results are shown in Table 61 below. 
     
       
         
           
               
               
               
             
               
                 TABLE 61 
               
               
                   
               
               
                 No. 
                 Solvent 
                 Solid Form 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 1 
                 Ethyl Alcohol 
                 Crystalline Form VII 
               
               
                 2 
                 Methyl isobutyl ketone 
                 Crystalline Form V 
               
               
                 3 
                 Ethyl acetate 
                 Crystalline Form V 
               
               
                 4 
                 Methyl tert-butyl ether 
                 Crystalline Form IX 
               
               
                 5 
                 Acetonitrile 
                 Crystalline Form XI 
               
               
                 6 
                 n-Heptane 
                 Crystalline Form I 
               
               
                 7 
                 Water 
                 Amorphous Form 
               
               
                 8 
                 THF/Water (1:9) 
                 Crystalline Form I 
               
               
                   
               
            
           
         
       
     
     Example 61: Suspension Stirring Method at 50° C. was Used to Prepare Forms of Compound 1 
     15 mg of Compound 1 was weighed into a 1.5 mL glass vial, and added with 0.5 mL of solvent respectively to get turbid liquid, and standed at 50° C. under magnetic stirring for 5 days, and the centrifugal solids were collected and XRPD test was performed. The related results are shown in Table 62 below. 
     
       
         
           
               
               
               
             
               
                 TABLE 62 
               
               
                   
               
               
                 No. 
                 Solvent 
                 Solid Form 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 1 
                 Ethyl Alcohol 
                 Crystalline Form VI 
               
               
                 2 
                 Methyl isobutyl ketone 
                 Crystalline Form III 
               
               
                 3 
                 Ethyl acetate 
                 Crystalline Form V 
               
               
                 4 
                 Methyl tert-butyl ether 
                 Crystalline Form VIII 
               
               
                 5 
                 Acetonitrile 
                 Crystalline Form IX 
               
               
                 6 
                 Water 
                 Amorphous Form 
               
               
                 7 
                 THF/Water (1:9) 
                 Crystalline Form III 
               
               
                   
               
            
           
         
       
     
     Example 62: Slow Cooling Method was Used to Prepare Forms of Compound 1 
     15 mg of Compound 1 was weighed into a 3 mL glass vial, and added with 1.0 mL of solvent, and standed at 50° C. under stirring for 1 hour to filter to obtain the supernatant. The resulting supernatant was cooled from 50° C. to 5° C. at 0.1° C./min and kept in a bio-incubator at a constant temperature at 5° C. The precipitated solids were collected and XRPD test was performed. The samples without precipitated solids were transferred to room temperature for volatilization. The related results are shown in Table 63 below. 
     
       
         
           
               
               
               
             
               
                 TABLE 63 
               
               
                   
               
               
                 No. 
                 Solvent 
                 Solid Form 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 1 
                 Ethyl acetate 
                 Crystalline Form V 
               
               
                 2 
                 Acetonitrile 
                 Amorphous Form 
               
               
                 3 
                 Toluene 
                 Amorphous Form 
               
               
                 4 
                 THF/Water (1:1) 
                 Crystalline Form XIV 
               
               
                 5 
                 Trichloromethane/Heptane(1:1) 
                 Amorphous Form 
               
               
                   
               
            
           
         
       
     
     Example 63: Gas-Solid Penetration Method was Used to Prepare Forms of Compound 1 
     15 mg of Compound 1 was weighed into a 3 mL vial. Another 20 mL bottle was taken to add with 2 mL of solvent. The 3 mL open vial was put into the 20 mL bottle. The 20 mL bottle was sealed and standed at room temperature for 7 days, and the solids were collected and XRPD test was performed. The related results are shown in Table 64 below. 
     
       
         
           
               
               
               
             
               
                 TABLE 64 
               
               
                   
               
               
                 No. 
                 Solvent 
                 Solid Form 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 1 
                 Water 
                 Crystalline Form I 
               
               
                 2 
                 Ethyl Alcohol 
                 Crystalline Form XV 
               
               
                 3 
                 Acetone 
                 Crystalline Form XVII 
               
               
                 4 
                 Ethyl acetate 
                 Crystalline Form V 
               
               
                 5 
                 Methyl tert-butyl ether 
                 Crystalline Form IX 
               
               
                 6 
                 Acetonitrile 
                 Crystalline Form XI 
               
               
                 7 
                 2-Methyltetrahydrofuran 
                 Crystalline Form XVII 
               
               
                 8 
                 1,4-Dioxane 
                 Crystalline Form IV 
               
               
                 9 
                 Methanol 
                 Crystalline Form VII 
               
               
                 10 
                 DMF 
                 Crystalline Form XVI 
               
               
                   
               
            
           
         
       
     
     Example 64: Competitive Experiment 
     To study the stability relationship between anhydrous Crystalline Forms of the compound 1, suspension competitive agitation tests were carried out at different temperatures and in different solvents. With crystalline form I, crystalline form III, crystalline form XV, crystalline form XVII and crystalline form XVIII as raw materials, the suspension samples were suspended and stirred for 3 days in the saturated solution of IPA and MTBE at different temperatures (room temperature, 50° C. and 70° C.), and then the samples were centrifuged to separate and the solid XRPD was tested. The results were summarized in Table 65 below. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 65 
               
               
                   
               
               
                 Starting Material 
                 Solvent 
                 Temperature 
                 Crystalline Form 
               
               
                   
               
             
            
               
                 Crystalline Form I, 
                 IPA 
                 Room 
                 Crystalline Form III 
               
               
                 Crystalline Form III, 
                   
                 temperature 
               
               
                 Crystalline Form XV, 
                   
                 50° C. 
                 Crystalline Form III 
               
               
                 Crystalline Form XVII, 
                   
                 70° C. 
                 Crystalline Form III 
               
               
                 Crystalline Form XVIII 
                 MTBE 
                 Room 
                 Crystalline Form III 
               
               
                   
                   
                 temperature 
               
               
                   
                   
                 50° C. 
                 Crystalline Form III 
               
               
                   
                   
                 70° C. 
                 Crystalline Form III 
               
               
                   
               
            
           
         
       
     
     To study the stability relationship between Crystalline Form III and Crystalline Form XVIII, using Crystalline Form III and Crystalline Form XVIII as raw materials, suspension samples were suspended and stirred in a saturated solution of 3 solvents (EtOAc, MTBE and n-butyl alcohol) at different temperatures (room temperature, 50° C. and 70° C.) for 7 days, and then the samples were centrifuged to separate and the XRPD of solid was tested. The results were summarized in Table 66 below. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 66 
               
               
                   
               
               
                 Starting Material 
                 Slovent 
                 Temperature 
                 Crystalline Form 
               
               
                   
               
             
            
               
                 Crystalline Form III 
                 EtOAc 
                 Room 
                 Crystalline Form V 
               
               
                 and Crystalline Form 
                   
                 temperature 
               
               
                 XVIII 
                   
                 50° C. 
                 Crystalline Form III 
               
               
                   
                   
                 70° C. 
                 Crystalline Form III 
               
               
                   
                 MTBE 
                 Room 
                 Crystalline Form III + 
               
               
                   
                   
                 temperature 
                 Crystalline Form XVIII 
               
               
                   
                   
                 50° C. 
                 Crystalline Form III 
               
               
                   
                   
                 70° C. 
                 Crystalline Form III 
               
               
                   
                 n-Butyl 
                 Room 
                 Crystalline Form III + 
               
               
                   
                 alcohol 
                 temperature 
                 Crystalline Form XVIII 
               
               
                   
                   
                 50° C. 
                 Crystalline Form III 
               
               
                   
                   
                 70° C. 
                 Crystalline Form III 
               
               
                   
               
            
           
         
       
     
     The interconversion rate of crystalline form III and crystalline form XVIII at room temperature is relatively slow, and the stability of crystalline form III and crystalline form XVIII at room temperature is similar. 
     Example 65: Stability Test 
     (1) The crystalline form III, crystalline form XVIII and amorphous form XXV was placed at 80° C. (sealed) for 24 hours, at 40° C./75% RH and 25° C./60% RH (open) for 1 week, respectively. The physical and chemical stability of the samples were tested by XRPD and HPLC. The test data are listed in Table 67. The crystalline form of the three samples did not change after being placed under the three conditions, showing good physical stability. The HPLC purity results showed that the three samples did not degrade after being placed under the three conditions, showing good chemical stability. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 67 
               
               
                   
               
               
                 Form at starting 
                   
                 purity 
                   
               
               
                 point 
                 Condition 
                 (area %) 
                 Form 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Crystalline Form 
                 starting point 
                 98.65 
                 Crystalline Form 
               
               
                 III 
                   
                   
                 III 
               
               
                   
                 80° C. 24 hours 
                 98.64 
                 Crystalline Form 
               
               
                   
                   
                   
                 III 
               
               
                   
                 25° C./60% RH 
                 98.66 
                 Crystalline Form 
               
               
                   
                 1 week 
                   
                 III 
               
               
                   
                 40° C./75% RH 
                 98.67 
                 Crystalline Form 
               
               
                   
                 1 week 
                   
                 III 
               
               
                 Crystalline Form 
                 starting point 
                 99.48 
                 Crystalline Form 
               
               
                 XVIII 
                   
                   
                 XVIII 
               
               
                   
                 80° C. 24 hours 
                 99.61 
                 Crystalline Form 
               
               
                   
                   
                   
                 XVIII 
               
               
                   
                 25° C./60% RH 
                 99.60 
                 Crystalline Form 
               
               
                   
                 1 week 
                   
                 XVIII 
               
               
                   
                 40° C./75% RH 
                 99.61 
                 Crystalline Form 
               
               
                   
                 1 week 
                   
                 XVIII 
               
               
                 Amorphous 
                 starting point 
                 99.43 
                 Amorphous 
               
               
                 form XXV 
                   
                   
                 form XXV 
               
               
                   
                 80° C. 24 hours 
                 99.42 
                 Amorphous 
               
               
                   
                   
                   
                 form XXV 
               
               
                   
                 25° C./60% RH 
                 99.42 
                 Amorphous 
               
               
                   
                 1 week 
                   
                 form XXV 
               
               
                   
                 40° C./75% RH 
                 99.45 
                 Amorphous 
               
               
                   
                 1 week 
                   
                 form XXV 
               
               
                   
               
            
           
         
       
     
     (2) Weigh 20˜30 mg of the salt crystalline form of the compound 1 into an 8 mL glass bottle, and then place it at high temperature (60° C., open), high humidity (room temperature/75RH, open) and light (room temperature, white light: 6980 lux, UV 282 μW/cm2), samples were taken on the 5th, 10th, and 30th day for detection (HPLC, XRPD). The results are shown in Table 68-75. 
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 68 
               
               
                   
               
               
                   
                   
                   
                 total 
                   
               
               
                 Sample 
                 Test condition 
                 Time point 
                 impurities (%) 
                 XPRD 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 XXVII 
                 The initial sample 
                 0 
                 day 
                 1.19 
                 XXVII 
               
               
                   
                 60° C. 
                 5 
                 days 
                 1.26 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 1.22 
                 No change 
               
               
                   
                 light 
                   
                   
                 1.20 
                 No change 
               
               
                   
                 60° C. 
                 10 
                 days 
                 1.37 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 1.25 
                 No change 
               
               
                   
                 light 
                   
                   
                 1.28 
                 No change 
               
               
                   
                 60° C. 
                 30 
                 days 
                 1.33 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 1.27 
                 No change 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 69 
               
               
                   
               
               
                   
                   
                   
                 total 
                   
               
               
                 Sample 
                 Test condition 
                 Time point 
                 impurities (%) 
                 XPRD 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 XXIX 
                 The initial sample 
                 0 
                 day 
                 0.65 
                 XXIX 
               
               
                   
                 60° C. 
                 5 
                 days 
                 0.64 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.65 
                 No change 
               
               
                   
                 light 
                   
                   
                 0.64 
                 No change 
               
               
                   
                 60° C. 
                 10 
                 days 
                 0.65 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.65 
                 No change 
               
               
                   
                 light 
                   
                   
                 0.59 
                 No change 
               
               
                   
                 60° C. 
                 30 
                 days 
                 0.66 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.60 
                 No change 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 70 
               
               
                   
               
               
                   
                   
                   
                 total 
                   
               
               
                 Sample 
                 Test condition 
                 Time point 
                 impurities (%) 
                 XPRD 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 XXX 
                 The initial sample 
                 0 
                 day 
                 0.80 
                 XXX 
               
               
                   
                 60° C. 
                 5 
                 days 
                 0.89 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.82 
                 No change 
               
               
                   
                 light 
                   
                   
                 0.82 
                 No change 
               
               
                   
                 60° C. 
                 10 
                 days 
                 0.92 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.86 
                 No change 
               
               
                   
                 light 
                   
                   
                 1.02 
                 No change 
               
               
                   
                 60° C. 
                 30 
                 days 
                 0.83 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.74 
                 No change 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 71 
               
               
                   
               
               
                   
                   
                   
                 total 
                   
               
               
                 Sample 
                 Test condition 
                 Time point 
                 impurities (%) 
                 XPRD 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 XXXIX 
                 The initial sample 
                 0 
                 day 
                 0.76 
                 XXXIX 
               
               
                   
                 60° C. 
                 5 
                 days 
                 0.90 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.80 
                 No change 
               
               
                   
                 light 
                   
                   
                 0.88 
                 No change 
               
               
                   
                 60° C. 
                 10 
                 days 
                 0.89 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.82 
                 No change 
               
               
                   
                 light 
                   
                   
                 1.02 
                 No change 
               
               
                   
                 60° C. 
                 30 
                 days 
                 0.86 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.81 
                 No change 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 72 
               
               
                   
               
               
                   
                   
                   
                 total 
                   
               
               
                 Sample 
                 Test condition 
                 Time point 
                 impurities (%) 
                 XPRD 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 XXXVI 
                 The initial sample 
                 0 
                 day 
                 1.02 
                 XXXVI 
               
               
                   
                 60° C. 
                 5 
                 days 
                 0.97 
                 changed 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.95 
                 XXXVI 
               
               
                   
                   
                   
                   
                   
                 A slight 
               
               
                   
                   
                   
                   
                   
                 change 
               
               
                   
                 light 
                   
                   
                 1.06 
                 no change 
               
               
                   
                 60° C. 
                 10 
                 days 
                 1.01 
                 changed 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.95 
                 XXXVI 
               
               
                   
                   
                   
                   
                   
                 A slight 
               
               
                   
                   
                   
                   
                   
                 change 
               
               
                   
                 light 
                   
                   
                 1.36 
                 no change 
               
               
                   
                 60° C. 
                 30 
                 days 
                 0.98 
                 changed 
               
               
                   
                 RT/75% RH 
                   
                   
                 1.00 
                 XXXVI 
               
               
                   
                   
                   
                   
                   
                 A slight 
               
               
                   
                   
                   
                   
                   
                 change 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 73 
               
               
                   
               
               
                   
                   
                   
                 total 
                   
               
               
                 Sample 
                 Test condition 
                 Time point 
                 impurities (%) 
                 XPRD 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 XL 
                 The initial sample 
                 0 
                 day 
                 0.91 
                 XL 
               
               
                   
                 60° C. 
                 5 
                 days 
                 1.15 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.93 
                 No change 
               
               
                   
                 light 
                   
                   
                 1.08 
                 No change 
               
               
                   
                 60° C. 
                 10 
                 days 
                 1.18 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 1.06 
                 No change 
               
               
                   
                 light 
                   
                   
                 1.18 
                 No change 
               
               
                   
                 60° C. 
                 30 
                 days 
                 1.28 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.90 
                 XL 
               
               
                   
                   
                   
                   
                   
                 A slight 
               
               
                   
                   
                   
                   
                   
                 change 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 74 
               
               
                   
               
               
                   
                   
                   
                 total 
                   
               
               
                 Sample 
                 Test condition 
                 Time point 
                 impurities (%) 
                 XPRD 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 XXIV 
                 The initial sample 
                 0 
                 day 
                 0.50 
                 XXIV 
               
               
                   
                 60° C. 
                 5 
                 days 
                 0.48 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.50 
                 No change 
               
               
                   
                 light 
                   
                   
                 0.73 
                 No change 
               
               
                   
                 60° C. 
                 10 
                 days 
                 0.48 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.50 
                 No change 
               
               
                   
                 light 
                   
                   
                 0.72 
                 No change 
               
               
                   
                 60° C. 
                 30 
                 days 
                 0.61 
                 No change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.50 
                 No change 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
             
               
                 TABLE 75 
               
               
                   
               
               
                   
                   
                   
                 total 
                   
               
               
                 Sample 
                 Test condition 
                 Time point 
                 impurities (%) 
                 XPRD 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 XXXIII 
                 The initial sample 
                 0 
                 day 
                 0.67 
                 XXXIII 
               
               
                   
                 60° C. 
                 5 
                 days 
                 0.90 
                 XXXIII 
               
               
                   
                   
                   
                   
                   
                 A slight 
               
               
                   
                   
                   
                   
                   
                 change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.67 
                 XXXIII 
               
               
                   
                   
                   
                   
                   
                 A slight 
               
               
                   
                   
                   
                   
                   
                 change 
               
               
                   
                 light 
                   
                   
                 0.84 
                 No change 
               
               
                   
                 60° C. 
                 10 
                 days 
                 0.91 
                 XXXIII 
               
               
                   
                   
                   
                   
                   
                 A slight 
               
               
                   
                   
                   
                   
                   
                 change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.71 
                 XXXIII 
               
               
                   
                   
                   
                   
                   
                 A slight 
               
               
                   
                   
                   
                   
                   
                 change 
               
               
                   
                 light 
                   
                   
                 1.09 
                 No change 
               
               
                   
                 60° C. 
                 30 
                 days 
                 1.11 
                 XXXIII 
               
               
                   
                   
                   
                   
                   
                 A slight 
               
               
                   
                   
                   
                   
                   
                 change 
               
               
                   
                 RT/75% RH 
                   
                   
                 0.70 
                 XXXIII 
               
               
                   
                   
                   
                   
                   
                 A slight 
               
               
                   
                   
                   
                   
                   
                 change 
               
               
                   
               
            
           
         
       
     
     Example 66. The Evaluation of Hygroscopicity 
     Started with 0 humidity (0% RH) through the Dynamic Moisture Sorption Analyzer (DVS), under constant temperature conditions, when the humidity changed (0% RH-95% RH-0% RH), the moisture adsorption of the crystalline form III at 80% RH/25° C. is 0.9%, showing slight hygroscopicity. The XRPD characterization result of the sample after the DVS test indicated that the crystalline form III did not change after the DVS test ( FIGS.  166 - 167   ). 
     The test results of the crystalline form XVIII are shown in  FIGS.  168 - 169   . The moisture adsorption of the crystalline form XVIII at 80% RH/25° C. is 0.04%, showing almost no moisture absorption. The XRPD characterization result of the sample after the DVS test indicates that the crystalline form XVIII did not change after the DVS test. 
     The DVS diagrams, weight increase by hygroscopy and XRPD results before and after DVS of some salt crystalline forms are shown in Table 76 and  FIGS.  170 - 177   . 
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 76 
               
               
                   
                   
               
               
                   
                   
                 weight increase by hygroscopy 
                   
               
               
                   
                 Form 
                 (80% RH) 
                 XRPD change 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 XXVII 
                 3.32% 
                 no change 
               
               
                   
                 XXIX 
                 0.948% 
                 no change 
               
               
                   
                 XXX 
                 0.90% 
                 no change 
               
               
                   
                 XXXIX 
                 0.37% 
                 no change 
               
               
                   
                 XXXVI 
                 2.00% 
                 no change 
               
               
                   
                 XL 
                 1.41% 
                 no change 
               
               
                   
                 XXIV 
                 1.246% 
                 changed 
               
               
                   
                 XXXIII 
                 7.82% 
                 changed 
               
               
                   
                   
               
            
           
         
       
     
     Each reference, including all patents, patent applications and publications referenced in this application, is incorporated herein by reference in its entirety as if each of them were incorporated separately. In addition, it is understood that in the teaching of the present invention, the technicians in the art may make certain changes or modifications to the present invention and that these equivalents will remain within the scope of the present invention as limited by the claims appended to the application.