Patent Publication Number: US-2019192646-A1

Title: Salmonella vaccines

Description:
RELATED APPLICATIONS 
     This application claims the benefit under 35 U.S.C. § 119(e) of U.S. provisional application No. 62/589,192, filed Nov. 21, 2017, and U.S. provisional application No. 62/581,562, filed Nov. 3, 2017. Each of which is incorporated by reference herein in its entirety. 
    
    
     BACKGROUND 
       Salmonella  infection ( salmonellosis ) causes approximately one million foodborne illnesses yearly in the United States, with 19,000 hospitalizations and 380 deaths. Most individuals infected with  Salmonella  develop diarrhea, fever, and abdominal cramps 12 to 72 hours after infection. The illness usually lasts 4 to 7 days, and most recover without treatment. In some, however, the symptoms are so severe that the patient needs to be hospitalized. In these patients, the  Salmonella  infection may spread from the intestines to the blood stream, and then to other body sites, which can result in death unless the person is treated promptly with antibiotics. The elderly, infants, and those with impaired immune systems are more likely to have a severe infection. Currently, there is no vaccine to prevent  salmonellosis.    
     SUMMARY 
     Provided herein, in some embodiments, are RNA (e.g., mRNA) vaccines, such as multivalent RNA vaccines, that elicit potent neutralizing antibodies and robust T cell responses against  Salmonella  antigens. The RNA vaccines of the present disclosure, despite encoding bacterial antigens, are highly stable and highly expressed on the surface of mammalian cells. Thus, some aspects of the present disclosure provide  Salmonella  vaccines comprising a RNA having an open reading frame (ORF) encoding a (at least one)  Salmonella  antigen, wherein intramuscular (IM) administration of a therapeutically effective amount of the vaccine to a subject induces in the subject a neutralizing antibody titer and/or a T cell immune response (e.g., a CD4 +  and/or a CD8 +  T cell response). 
     In some aspects, the present disclosure provides a multivalent  Salmonella  vaccine, comprising (a) a RNA having an ORF encoding two (at least two)  Salmonella  antigens, or (b) two RNAs (at least two RNAs), each having an ORF encoding a  Salmonella  antigen, wherein IM administration of a therapeutically effective amount of the vaccine to a subject induces in the subject a neutralizing antibody titer and/or a T cell immune response. 
     In some embodiments, the vaccine comprises a (at least one) RNA having an ORF encoding two (at least two)  Salmonella  antigens formulated in a lipid nanoparticle. In some embodiments, the vaccine comprises two (at least two) RNAs, each having an ORF encoding a (at least one)  Salmonella  antigen, wherein the two RNAs are formulated together in a single lipid nanoparticle. In some embodiments, the vaccine comprises two (at least two) RNAs, each having an ORF encoding a (at least one)  Salmonella  antigen, wherein each RNA is formulated separately in a single lipid nanoparticle (one RNA in one lipid nanoparticle, the other RNA in another lipid nanoparticle). In some embodiments, the vaccine further comprises at least one (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10) additional RNA having an ORF encoding at least one (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10) additional  Salmonella  antigen. The additional RNA(s) may be formulated with one of the other RNA(s) or may be formulated separately. 
     In some embodiments, the lipid nanoparticle comprises a molar ratio of 20-60% ionizable cationic lipid, 5-25% non-cationic lipid, 25-55% sterol, and 0.5-15% PEG-modified lipid. 
     In some embodiments, the  Salmonella  antigens are selected from the group consisting of: SseB, Mig14, OmpL, OmpC, OmpD, OmpF, IroN, CirA, FepA, T0937, FliC, PilL, PltB, PltA, CdtB, SlyB, STY1086 and STY0796. For example, the  Salmonella  antigens may include PltB, PltA, CdtB. In some embodiments, the  Salmonella  antigens include PltB, PltA, CdtB and at least one  Salmonella  antigen selected from the group consisting of: SseB, Mig14, OmpL, OmpC, OmpD, OmpF, IroN, CirA, FepA, T0937, FliC, PilL, SlyB, STY1086 and STY0796. 
     In some embodiments, each  Salmonella  antigen is of a different serotype. For example, the serotypes may be selected from the group consisting of:  enterica  (serotype I),  salamae  (serotype II),  arizonae  (Ma),  diarizonae  (Mb),  houtenae  (IV), and  indica  (VI). 
     In some embodiments, the  Salmonella  antigens are fused to a scaffold moiety. For example, the  Salmonella  antigens may be fused to a scaffold moiety is selected from the group consisting of: ferritin, encapsulin, lumazine synthase, hepatitis B surface antigen, and hepatitis B core antigen. 
     In some embodiments, the neutralizing antibody titer is at least 100 neutralizing units per milliliter (U/ml) (e.g., 150, 200, 250, 300, 350, 400, or 450 U/ml). In some embodiments, the neutralizing antibody titer is at least 500 U/ml (e.g., 550, 600, 650, 700, 750, 800, 850, 900, or 950 U/ml) or at least 1000 U/ml (e.g., 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000, 5500, 6000, 6500, 7000, 7500, 8000, 8500, 9000, or 9500 U/ml). In some embodiments, the neutralizing antibody titer is at least 10,000 U/ml. 
     In some embodiments, the neutralizing antibody titer is induced in the subject following fewer than three (one or two) doses of the vaccine. 
     In some embodiments, the  Salmonella  antigen is expressed on the surface of cells of the subject (e.g., a human subject). In some embodiments, the subject is immunocompromised (e.g., has an autoimmune condition and/or is an elderly subject). 
     In some embodiments, the neutralizing antibody titer is induced within 20 days (e.g., within 10 or 15 days) following a single 10-100 μg dose of the vaccine. In some embodiments, the neutralizing antibody titer is induced within 20 days following a 10 μg dose of the vaccine. In some embodiments, the neutralizing antibody titer is induced within 20 days following a 20 μg dose of the vaccine. In some embodiments, the neutralizing antibody titer is induced within 20 days following a 30 μg dose of the vaccine. In some embodiments, the neutralizing antibody titer is induced within 20 days following a 40 μg dose of the vaccine. In some embodiments, the neutralizing antibody titer is induced within 20 days following a 50 μg dose of the vaccine. In some embodiments, the neutralizing antibody titer is induced within 20 days following a 60 μg dose of the vaccine. In some embodiments, the neutralizing antibody titer is induced within 20 days following a 70 μg dose of the vaccine. In some embodiments, the neutralizing antibody titer is induced within 20 days following a 80 μg dose of the vaccine. In some embodiments, the neutralizing antibody titer is induced within 20 days following a 90 μg dose of the vaccine. In some embodiments, the neutralizing antibody titer is induced within 20 days following a 100 μg dose of the vaccine. 
     In some embodiments, the neutralizing antibody titer is induced within 40 days following a second 10-100 μg dose (e.g., 10 μg, 20 μg, 30 μg, 40 μg, 50 μg, 60 μg, 70 μg, 80 μg, 90 μg, or 100 μg dose) of the vaccine. 
     In some embodiments, the T cell immune response comprises a CD4 +  T cell immune response. In some embodiments, the T cell immune response comprises a CD8 +  T cell immune response. In some embodiments, the T cell immune response comprises a CD4 +  T cell immune response and a CD8 +  T cell immune response. 
     In some embodiments, the RNA comprises or consists of messenger RNA (mRNA). 
     In some embodiments, the RNA further comprises a 5′ UTR (e.g., SEQ ID NO: 3 or 140) and/or a 3′ UTR (e.g., SEQ ID NO: 4 or 129). 
     In some embodiments, the  Salmonella  antigen is fused to a signal peptide. 
     In some embodiments, the RNA is unmodified. In other embodiments, the RNA comprise at least one modified nucleotide. For example, at least 80% of the uracil in the ORF may comprise a 1-methyl-pseudouridine modification. 
     Other aspects of the present disclosure provide a method comprising administering to a subject the  Salmonella  vaccine as provided herein in a therapeutically effective amount to induce in the subject a neutralizing antibody titer and/or a T cell immune response. 
     In some embodiments, the efficacy of the  Salmonella  vaccine is at least 80% (e.g., 80%, 85%, 90% or 95%) relative to unvaccinated control subjects (e.g. human subjects). In some embodiments, detectable levels of  Salmonella  antigen are produced in the serum of the subject at 1-72 hours post administration of the vaccine. 
     In some embodiments, a neutralizing antibody titer of at least 100 U/ml (e.g., 150, 200, 250, 300, 350, 400, or 450 U/ml) is produced in the serum of the subject at 1-72 hours post administration of the vaccine. For example, a neutralizing antibody titer of at least 500 U/ml (e.g., 550, 600, 650, 700, 750, 800, 850, 900, or 950 U/ml) or at least 1000 U/ml (e.g., 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000, 5500, 6000, 6500, 7000, 7500, 8000, 8500, 9000, or 9500 U/ml) may be produced in the serum of the subject at 1-72 hours post administration of the vaccine. 
     In some embodiments, the therapeutically effective amount is a total dose of 20 μg-200 μg. For example, the therapeutically effective amount may be a total dose of 50 μg-100 μg. 
     The LNP used in the studies described herein has been used previously to deliver siRNA in various animal models as well as in humans. In view of the observations made in association with the siRNA delivery of LNP formulations, the fact that LNP is useful in vaccines is quite surprising. It has been observed that therapeutic delivery of siRNA formulated in LNP causes an undesirable inflammatory response associated with a transient IgM response, typically leading to a reduction in antigen production and a compromised immune response. In contrast to the findings observed with siRNA, the LNP-mRNA formulations of the invention are demonstrated herein to generate enhanced IgG levels, sufficient for prophylactic and therapeutic methods rather than transient IgM responses. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIGS. 1A-1B  show CD4 +  ( FIG. 1A ) and CD8 +  ( FIG. 1B ) T cell responses in mice following immunization on days 1 and 29 with a vaccine comprising mRNA encoding  Salmonella  SseB antigen encapsulated in lipid nanoparticles. Two doses, 2 μg and 10 μg, were tested. Levels of IFNγ, TNFα, and IL2 were measured. 
         FIGS. 2A-2B  show CD4 +  ( FIG. 2A ) and CD8 +  ( FIG. 2B ) T cell responses in mice immunization on days 1 and 29 with a vaccine comprising mRNA encoding  Salmonella  Mig14 antigen or a non-glycosylated (NGM) version of  Salmonella  Mig14 antigen encapsulated in lipid nanoparticles. Two doses, 2 μg and 10 μg, were tested. Levels of IFNγ, TNFα, and IL2 were measured. 
     
    
    
     DETAILED DESCRIPTION 
       Salmonella  is a genus of intracellular rod-shaped gram-negative bacterial pathogens of the Enterobacteriaceae family. There are two species of  Salmonella: Salmonella bongori  and  Salmonella enterica. Salmonella enterica , found worldwide in all warm-blood animals and in the environment, is further divided into six subspecies that that include over 2,500 serotypes, many of which (e.g., nontyphoidal serotypes) cause illness. These six subspecies are  enterica  (serotype I),  salamae  (serotype II),  arizonae  (Ma),  diarizonae  (111b),  houtenae  (IV), and  indica  (VI). 
     Infection with nontyphoidal serotypes of  Salmonella  generally results in food poisoning, while infection with typhoidal serotypes, such as  Salmonella Typhi, Paratyphi  A,  Paratyphi  B and  Paratyphi  C, causes typhoid fever.  Salmonella  serotypes that cause typhoid fever are strictly adapted to humans or higher primates. These salmonellae can pass through the lymphatic system of the intestine into the blood of patients, invading various organs (e.g., liver, spleen, and kidneys) to form secondary foci. Endotoxins first act on the vascular and nervous apparatus, resulting in increased permeability and decreased tone of the vessels, upset of thermal regulation, vomiting and diarrhea. In severe forms of the disease, enough liquid and electrolytes are lost to upset water-salt metabolism, decrease circulating blood volume and arterial pressure, and cause hypovolemic shock. Septic shock may also develop. Shock of mixed character (with signs of both hypovolemic and septic shock) is more common in severe  salmonellosis . Oliguria and azotemia may develop in severe cases as a result of renal involvement owing to hypoxia and toxemia. 
       Salmonella  infection is currently treated with antibiotics; however, some strains of  salmonella  are quickly developing antibiotic resistance. Currently, there is no vaccine available to prevent this bacterial infection. The present disclosure provides RNA (e.g., mRNA) vaccines against  Salmonella  infection—vaccines that elicit potent neutralizing antibodies and/or robust T cell responses against  Salmonella  antigens. 
     The vaccines disclosed herein may also be used therapeutically, i.e., following infection with  Salmonella  (to treat the infection). RNA vaccines disclosed herein have been demonstrated to result in expression of  Salmonella  proteins in eukaryotic cells and can induce an immune response in an animal model, as disclosed in the Examples section. 
     The  Salmonella  RNA vaccines described herein are superior to current vaccines in several ways. For example, the lipid nanoparticle (LNP) delivery system used herein increases the efficacy of RNA vaccines in comparison to other formulations, including a protamine-based approach described in the literature. The use of this LNP delivery system enables the effective delivery of chemically-modified RNA vaccines or unmodified RNA vaccines, without requiring additional adjuvant to produce a therapeutic result (e.g., production neutralizing antibody titer and/or a T cell response). In some embodiments, the  Salmonella  RNA vaccines disclosed herein are superior to conventional vaccines by a factor of at least 10 fold, 20, fold, 40, fold, 50 fold, 100 fold, 500 fold, or 1,000 fold when administered intramuscularly (IM) or intradermally (ID). These results can be achieved even when significantly lower doses of the RNA (e.g., mRNA) are administered in comparison with RNA doses used in other classes of lipid based formulations. These results are surprising because even at the very low doses tested, administration of the  Salmonella  RNA vaccines of the present disclosure results in appropriate expression of bacterial antigens in eukaryotic cells of the host and the induction of neutralizing immunity. 
     Exemplary  Salmonella  Antigens 
     Antigens are proteins capable of inducing an immune response (e.g., causing an immune system to produce antibodies against the antigens). Herein, use of the term antigen encompasses immunogenic proteins and immunogenic fragments (an immunogenic fragment that induces (or is capable of inducing) an immune response to  Salmonella ), unless otherwise stated. It should be understood that the term “protein” encompasses peptides and the term “antigen” encompasses antigenic fragments. 
     A number of different antigens are associated with  Salmonella. Salmonella  vaccines, as provided herein, comprise at least one (one or more) ribonucleic acid (RNA, e.g., mRNA) polynucleotide having an open reading frame encoding at least one  Salmonella  antigen. Non-limiting examples of  Salmonella  antigens are provided below. 
     Exemplary  Salmonella  antigens are provided in the Sequence Listing elsewhere herein. For example, the antigens may be encoded by (thus the RNA may comprise or consist of) any one of sequences set forth in SEQ ID NO: 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, and/or 234. In some embodiments, the aforementioned sequences may further comprise a 5′ cap (e.g., 7mG(5′)ppp(5′)NlmpNp), a polyA tail, or a 5′ cap and a polyA tail. 
     Secreted effector protein, SseB, alters host cell physiology and promotes bacterial survival in host tissues. It is required for the correct localization of SseC and SseD on the bacterial cell surface (Nikolaus et al.,  J. Bacteriolo.  183:6036-605 (2001)). In some embodiments, a  Salmonella  vaccine of the present disclosure comprises a RNA (e.g., mRNA) encoding a SseB antigen. In some embodiments, the  Salmonella  SseB antigen comprises the sequence identified by SEQ ID NO: 25 (St_SseB) or SEQ ID NO: 20 (St_SseB_nIgK), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 25 or SEQ ID NO: 20. In some embodiments, the  Salmonella  SseB antigen is encoded by the sequence identified by SEQ ID NO: 26 or SEQ ID NO: 30, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 26 or SEQ ID NO: 30. 
     Mig14 is a host-induced virulence gene in  Salmonella typhi  and  S. typhimurium , and plays an important role in cell invasion, and may be involved in flagellation, motility and chemotaxis of the bacterium as well (Sheng et al.,  Res Microbiol.,  164(9):903-912 (2013)). The inner membrane-associated protein, Mig14, provides resistance to cathelin-related anti-microbial peptide (CRAMP), which is highly expressed in activated macrophages, by preventing CRAMP from entering the inner membrane and therefore enhancing  Salmonella  survival (Brodsky et al.,  Mol Microbiol.  55(3): 954-972 (2005)). In some embodiments, the  Salmonella  Mig14 antigen comprises the sequence identified by SEQ ID NO: 55 (St_Mig14), SEQ ID NO: 59 (St_Mig14_nIgK), SEQ ID NO: 66 (St_Mig14_NGM) or SEQ ID NO: 67 (St_Mig14_NGM_nIgK), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 55, SEQ ID NO: 59, SEQ ID NO: 66 or SEQ ID NO: 67. In some embodiments, the  Salmonella  Mig14 antigen is encoded by the sequence identified by SEQ ID NO: 56, SEQ ID NO: 60, SEQ ID NO: 64 or SEQ ID NO: 68, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 56, SEQ ID NO: 60, SEQ ID NO: 64 or SEQ ID NO: 68. 
       Salmonella  outer membrane proteins (omp) OmpL, OmpC, OmpD, and OmpF are highly immunogenic porins, which stimulate innate and adaptive immune responses in the absence of adjuvants. These porins also induce the expression of co-stimulatory molecules on antigen-presenting cells through toll-like receptor canonical signaling pathways. Furthermore, these porins induce the release of TNF-α, IL-6, and IL18 (Galdiero et al.,  Microbiol.  147: 2697-2704 (2001)) and regulate the expression of CD80 and CD86 molecules on B cells and macrophages (Galdiero et al.,  Clinical Microbiol and Infection,  9(11): 1104-1111 (2003)). 
     In some embodiments, the  Salmonella  OmpL antigen comprises the sequence identified by SEQ ID NO: 103 (St_OmpL_nIgK) or SEQ ID NO: 107 (St_OmpL_NGM_IgK), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 103 or SEQ ID NO: 107. In some embodiments, the  Salmonella  OmpL antigen is encoded by the sequence identified by SEQ ID NO: 104 or SEQ ID NO: 108, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 104 or SEQ ID NO: 108. 
     In some embodiments, the  Salmonella  OmpC antigen comprises the sequence identified by SEQ ID NO: 5 (St_OmpC_nIgK) or SEQ ID NO: 21 (St_OmpC_NGM_IgK), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 5 or SEQ ID NO: 21. In some embodiments, the  Salmonella  OmpC antigen is encoded by the sequence identified by SEQ ID NO: 6 or SEQ ID NO: 22, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 6 or SEQ ID NO: 22. 
     In some embodiments, the  Salmonella  OmpD antigen comprises the sequence identified by SEQ ID NO: 17 (St_OmpD_nIgK_variant), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 17. In some embodiments, the  Salmonella  OmpD antigen is encoded by the sequence identified by SEQ ID NO: 18, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 18. 
     In some embodiments, the  Salmonella  OmpF antigen comprises the sequence identified by SEQ ID NO: 9 (St_OmpF_nIgK_variant) or SEQ ID NO: 13 (St_OmpF_NGM_IgK), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 9 or SEQ ID NO: 13. In some embodiments, the  Salmonella  OmpF antigen is encoded by the sequence identified by SEQ ID NO: 10 or SEQ ID NO: 14, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 10 or SEQ ID NO: 14. 
     It should be understood that while the foregoing  Salmonella  Omp antigens identified by SEQ ID NOs: 103, 107, 5, 21, 17, 9, or 13, or the RNA ORFs identified by SEQ ID NOs: 104, 108, 6, 22, 18, 10, or 14 include an N-terminal IgK signal sequence (SEQ ID NO: 153) (encoded by SEQ ID NO: 157)), the scope of the present disclosure also encompasses Omp antigens without the N-terminal IgK signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156). 
     FepA (ferrienterobactin receptor), IroN, and CirA are iron-regulated outer membrane proteins (IROMPs) located on  Salmonella enterica  serovar  typhimurium . The proteins are implicated in the uptake of enterobactin and may increase the capability of the bacterium to obtain iron using siderophore piracy (Rabsch et al.,  J of Bacteriol.  181(11):3610-3612 (1999)). The three are catecholate receptors; FepA and IroN are required for the transport of enterobactin, while all three proteins are receptors for 2,3-dihydroxybenzoylserine, an enterobactin breakdown product, which appears to play an important role in the virulence of  Salmonella enterica  (Rabsch et al., Infection and Immunity, 71(2):6953-6961 (2003)). 
     In some embodiments, the  Salmonella  FepA antigen comprises the sequence identified by SEQ ID NO: 91 (St_FepA_nIgK) or SEQ ID NO: 95 (St_FepA_NGM_nIgK), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 91 or SEQ ID NO: 95. In some embodiments, the  Salmonella  FepA antigen is encoded by the sequence identified by SEQ ID NO: 92 or SEQ ID NO: 96, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 92 or SEQ ID NO: 96. It should be understood that while the foregoing  Salmonella  FepA antigens identified by SEQ ID NOs: 91 or 95, or the RNA ORFs identified by SEQ ID NOs: 92 or 96 include an N-terminal IgK signal sequence (SEQ ID NO: 153) (encoded by SEQ ID NO: 157)), the scope of the present disclosure also encompasses FepA antigens without the N-terminal IgK signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156). 
     In some embodiments, the  Salmonella  IroN antigen comprises the sequence identified by SEQ ID NO: 73 (St_IroN_nFLRT2) or SEQ ID NO: 77 (St_IroN_NGM_nFLRT2), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 73 or SEQ ID NO: 77. In some embodiments, the  Salmonella  IroN antigen is encoded by the sequence identified by SEQ ID NO: 74 or SEQ ID NO: 78, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 74 or SEQ ID NO: 78. It should be understood that while the foregoing  Salmonella  IroN antigens identified by SEQ ID NOs: 73 or 77, or the RNA ORFs identified by SEQ ID NOs: 74 or 76 include an N-terminal FLRT2 signal sequence, the scope of the present disclosure also encompasses IroN antigens without the N-terminal FLRT2 signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156). 
     In some embodiments, the  Salmonella  CirA antigen comprises the sequence identified by SEQ ID NO: 81 (St_CirA_nFLRT2) or SEQ ID NO: 85 (St_CirA_NGM_nFLRT2), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 81 or SEQ ID NO: 85. In some embodiments, the  Salmonella  CirA antigen is encoded by the sequence identified by SEQ ID NO: 82 or SEQ ID NO: 86, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 82 or SEQ ID NO: 86. It should be understood that while the foregoing  Salmonella  CirA antigens identified by SEQ ID NOs: 81 or 85, or the RNA ORFs identified by SEQ ID NOs: 82 or 86 include an N-terminal FLRT2 signal sequence, the scope of the present disclosure also encompasses CirA antigens without the N-terminal FLRT2 signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156). 
     T0937 is expressed during infection and confers some level of protective immunity in a mouse model (Bumann,  Frontiers in Immunol.,  5(391):1-5 (2014)). In some embodiments, the  Salmonella  T0937 antigen comprises the sequence identified by SEQ ID NO: 132 (St_T0937_nIgK_NGM_cHis) or SEQ ID NO: 134 (St_T0937_nIgK_nTrunc_NGM_cHis), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 132 or SEQ ID NO: 134. In some embodiments, the  Salmonella  T0937 antigen is encoded by the sequence identified by SEQ ID NO: 133 or SEQ ID NO: 135, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 133 or SEQ ID NO: 135. It should be understood that while the foregoing  Salmonella  T0937 antigens identified by SEQ ID NOs: 132 or 134, or the RNA ORFs identified by SEQ ID NOs: 133 or 135 include an N-terminal IgK signal sequence (SEQ ID NO: 153) (encoded by SEQ ID NO: 157)) and a C-terminal His tag, the scope of the present disclosure also encompasses T0937 antigens without the N-terminal IgK signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156) and/or without the C-terminal His tag. 
     FliC is an antigenic form of flagella, and polymerizes to form the filaments of  Salmonella  flagella. It is expressed on the surface of  Salmonella  and is the target of host immune responses, as its invasion or translocation across the intestinal epithelium stimulates the innate immune receptor TLR5 to initiate an inflammatory response, as well as adaptive immune responses through FliC induction of antibody responses (Cummings et al., Mol Microbiol., 61(3): 795-809 (2006)). In some embodiments, the  Salmonella  FliC antigen comprises the sequence identified by SEQ ID NO: 33 (St_FliC), SEQ ID NO: 37 (St_FliC_nIgK), SEQ ID NO: 41 (SpA_FliC), SEQ ID NO: 45 (SpA_FliC_nIgK), SEQ ID NO: 49 (Stm_FliC) or SEQ ID NO: 53 (Stm_FliC_nIgK), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 41, or SEQ ID NO: 53. In some embodiments, the  Salmonella  FliC antigen is encoded by the sequence identified by SEQ ID NO: 34, SEQ ID NO: 38, SEQ ID NO: 42 or SEQ ID NO: 54, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 34, SEQ ID NO: 38, SEQ ID NO: 42 or SEQ ID NO: 54. It should be understood that while the foregoing  Salmonella  FliC antigens identified by SEQ ID NOs: 33, 37, 41 or 45, or the RNA ORFs identified by SEQ ID NOs: 34, 38, 42 or 46 include an N-terminal IgK signal sequence (SEQ ID NO: 153) (encoded by SEQ ID NO: 157)), the scope of the present disclosure also encompasses FliC antigens without the N-terminal IgK signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156). 
     Putative type IV pilus protein, PiIL, plays a role in the adhesion of  Salmonella  to INT407 cells in vitro, an interaction mediated directly instead of via aggregation (van Asten et al.,  FEMS Immunol  &amp;  Med Microbiol.,  44(3): 251-259 (2005)). The proteins are assembled in the inner membrane and moved through the periplasm to the outer membrane, where the pilus exits to the cell surface of the bacteria; however, the pilus remains connected to the inner membrane of the bacteria and can be retracted inside the bacteria, as necessary (Pan et al., Antimicrobial Agents and Chemotherapy, 49(10), 4052-4060 (2005)). In some embodiments, the  Salmonella  PiIL antigen comprises the sequence identified by SEQ ID NO: 127 (St_PiIL_nIgK) or SEQ ID NO: 130 (St_PiIL_NGM_nIgK), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 127 or SEQ ID NO: 130. In some embodiments, the  Salmonella  PiIL antigen is encoded by the sequence identified by SEQ ID NO: 128 or SEQ ID NO: 131, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 128 or SEQ ID NO: 131. It should be understood that while the foregoing  Salmonella  PiIL antigens identified by SEQ ID NOs: 127 or 130, or the RNA ORFs identified by SEQ ID NOs: 128 or 131 include an N-terminal IgK signal sequence (SEQ ID NO: 153) (encoded by SEQ ID NO: 157)), the scope of the present disclosure also encompasses PiIL antigens without the N-terminal IgK signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156). 
     PltB, PltA, and CdtB together form a tripartite toxin, cytolethal distending toxin (CDT). While CdtB is the functional cytolethal distending toxin, PltB and PltA are homologs of subunits of the pertussis toxin and are necessary for the delivery of CdtB from an intracellular compartment to target cells through both paracrine and autocrine pathway (Spano et al.,  Cell Host and Microbe,  3(1): 30-338 (2008)). The toxin has both a DNase activity from CdtB as well as an ADP-ribosylating activity associated with PltA, and has been found in both typhoidal and nontyphoidal  Salmonella  serotypes (Miller et al.,  Toxins,  8(5): 121-140 (2016)). In some embodiments, a  Salmonella  vaccine of the present disclosure comprises a mRNA encoding a PtlB antigen, a PltA antigen and/or a CdtB antigen. 
     In some embodiments, the  Salmonella  PltB antigen comprises the sequence identified by SEQ ID NO: 119 (St_PltB_nIgK) or SEQ ID NO: 123 (St_PltB_NGM_nIgK), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 119 or SEQ ID NO: 123. In some embodiments, the  Salmonella  PltB antigen is encoded by the sequence identified by SEQ ID NO: 120 or SEQ ID NO: 124, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 120 or SEQ ID NO: 124. It should be understood that while the foregoing  Salmonella  PltB antigens identified by SEQ ID NOs: 119 or 123, or the RNA ORFs identified by SEQ ID NOs: 120 or 124 include an N-terminal IgK signal sequence (SEQ ID NO: 153) (encoded by SEQ ID NO: 157)), the scope of the present disclosure also encompasses PltB antigens without the N-terminal IgK signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156). 
     In some embodiments, the  Salmonella  PltA antigen comprises the sequence identified by SEQ ID NO: 111 (St_PltA_nIgK) or SEQ ID NO: 115 (St_PltA_NGM_nIgK), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 111 or SEQ ID NO: 115. In some embodiments, the  Salmonella  PltA antigen is encoded by the sequence identified by SEQ ID NO: 112 or SEQ ID NO: 116, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 112 or SEQ ID NO: 116. It should be understood that while the foregoing  Salmonella  PltA antigens identified by SEQ ID NOs: 111 or 115, or the RNA ORFs identified by SEQ ID NOs: 112 or 116 include an N-terminal IgK signal sequence (SEQ ID NO: 153) (encoded by SEQ ID NO: 157)), the scope of the present disclosure also encompasses PltA antigens without the N-terminal IgK signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156). 
     In some embodiments, the  Salmonella  CdtB antigen comprises the sequence identified by SEQ ID NO: 97 (St_CdtB_nIgK), SEQ ID NO: 99 (St_CdtB_NGM_nIgK), SEQ ID NO: 138 (St_CdtB_Trunc_IgK_cHis) or SEQ ID NO: 141 (St_CdtB_Trunc_H160Q_IgK_cHis), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 97, SEQ ID NO: 99, SEQ ID NO: 138 or SEQ ID NO: 141. In some embodiments, the  Salmonella  CdtB antigen is encoded by the sequence identified by SEQ ID NO: 98, SEQ ID NO: 100, SEQ ID NO: 139 or SEQ ID NO: 142, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 98, SEQ ID NO: 100, SEQ ID NO: 139 or SEQ ID NO: 142. It should be understood that while the foregoing  Salmonella  CdtB antigens identified by SEQ ID NOs: 97, 99, 138 or 141, or the RNA ORFs identified by SEQ ID NOs: 98, 100, 139 or 142 include an N-terminal IgK signal sequence (SEQ ID NO: 153) (encoded by SEQ ID NO: 157)) or a C-terminal His tag, the scope of the present disclosure also encompasses CdtB antigens without the N-terminal IgK signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156) and/or without the C-terminal His tag. 
     SlyB, an outer membrane lipoprotein, is another  Salmonella  antigen. It negatively regulates PhoP activity and is essential to the PhoP/PhoQ system, which dictates the expression of Mg 2+  transporters and enzymes that alter Mg 2+  binding sites (Perez et al., PLOS Genetics, 5(3):e10000428 (2009)). In some embodiments, a  Salmonella  vaccine of the present disclosure comprises a mRNA encoding a SlyB antigen. In some embodiments, the  Salmonella  SlyB antigen comprises the sequence identified by SEQ ID NO: 136 (St_slyB_nIgK_NGM_cHis), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 136. In some embodiments, the  Salmonella  CdtB antigen is encoded by the sequence identified by SEQ ID NO: 137, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 137. It should be understood that while the foregoing  Salmonella  SlyB antigen identified by SEQ ID NO: 136, or the RNA ORF identified by SEQ ID NO: 137 includes an N-terminal IgK signal sequence (SEQ ID NO: 153) (encoded by SEQ ID NO: 157)) or a C-terminal His tag, the scope of the present disclosure also encompasses SlyB antigens without the N-terminal IgK signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156) and/or without the C-terminal His tag. 
     STY1086 is a putative lipoprotein found on the cell surface of  Salmonella  (Thieu et al., J of Infection, 75: 104-114 (2017)). In some embodiments, a  Salmonella  vaccine of the present disclosure comprises a mRNA encoding a STY1086 antigen. In some embodiments, the  Salmonella  STY1086 antigen comprises the sequence identified by SEQ ID NO: 147 (St_STY1086_nIgK_cHis) or SEQ ID NO: 149 (St_STY1086_NGM_nIgK_cHis), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 147 or SEQ ID NO: 149. In some embodiments, the  Salmonella  STY1086 antigen is encoded by the sequence identified by SEQ ID NO: 148 or SEQ ID NO: 150, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 148 or SEQ ID NO: 150. It should be understood that while the foregoing  Salmonella  STY1086 antigen identified by SEQ ID NOs: 147 or 149, or the RNA ORF identified by SEQ ID NOs: 148 or 150 include an N-terminal IgK signal sequence (SEQ ID NO: 153) (encoded by SEQ ID NO: 157)) or a C-terminal His tag, the scope of the present disclosure also encompasses STY1086 antigens without the N-terminal IgK signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156) and/or without the C-terminal His tag. 
     STY0796 (cell divisional coordinator CpoB) is a putative exported protein and is part of the Tol/pal system. It interacts with TolA and is involved in maintaining cell envelope integrity, including mediating the coordination of peptidoglycan synthesis and outer membrane constriction during division (Thieu et al., J of Infection, 75: 104-114 (2017)). In some embodiments, a  Salmonella  vaccine of the present disclosure comprises a mRNA encoding a STY0796 antigen. In some embodiments, the  Salmonella  STY0796 antigen comprises the sequence identified by SEQ ID NO: 143 (St_STY0796_nIgK_cHis) or SEQ ID NO: 145 (St_STY0796_NGM_nIgK_cHis), or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 143 or SEQ ID NO: 145. In some embodiments, the  Salmonella  STY0796 antigen is encoded by the sequence identified by SEQ ID NO: 144 or SEQ ID NO: 146, or a sequence at least 90% identical to the sequence identified by SEQ ID NO: 144 or SEQ ID NO: 146. It should be understood that while the foregoing  Salmonella  STY1086 antigen identified by SEQ ID NOs: 143 or 145, or the RNA ORF identified by SEQ ID NOs: 144 or 146 include an N-terminal IgK signal sequence (SEQ ID NO: 153) (encoded by SEQ ID NO: 157)) or a C-terminal His tag, the scope of the present disclosure also encompasses STY0796 antigens without the N-terminal IgK signal sequence or with an alternative signal sequence, such as any of those provided herein (e.g., SEQ ID NOs: 151, 152, 154, 155 or 156) and/or without the C-terminal His tag. 
     Nucleic Acids 
     The  Salmonella  vaccines of the present disclosure comprise at least one (one or more) ribonucleic acid (RNA) having an open reading frame encoding at least one  Salmonella  antigen. In some embodiments, the RNA is a messenger RNA (mRNA) having an open reading frame encoding at least one  Salmonella  antigen. In some embodiments, the RNA (e.g., mRNA) further comprises a 5′ UTR, 3′ UTR, a polyA tail and/or a 5′ cap. 
     Nucleic acids comprise a polymer of nucleotides (nucleotide monomers), also referred to as polynucleotides. Nucleic acids may be or may include, for example, deoxyribonucleic acids (DNAs), ribonucleic acids (RNAs), threose nucleic acids (TNAs), glycol nucleic acids (GNAs), peptide nucleic acids (PNAs), locked nucleic acids (LNAs, including LNA having a β-D-ribo configuration, α-LNA having an α-L-ribo configuration (a diastereomer of LNA), 2′-amino-LNA having a 2′-amino functionalization, and 2′-amino-α-LNA having a 2′-amino functionalization), ethylene nucleic acids (ENA), cyclohexenyl nucleic acids (CeNA) and/or chimeras and/or combinations thereof. 
     Messenger RNA (mRNA) is any ribonucleic acid that encodes a (at least one) protein (a naturally-occurring, non-naturally-occurring, or modified polymer of amino acids) and can be translated to produce the encoded protein in vitro, in vivo, in situ or ex vivo. The skilled artisan will appreciate that, except where otherwise noted, nucleic acid sequences set forth in the instant application may recite “T”s in a representative DNA sequence but where the sequence represents RNA (e.g., mRNA), the “T”s would be substituted for “U”s. Thus, any of the DNAs disclosed and identified by a particular sequence identification number herein also disclose the corresponding RNA (e.g., mRNA) sequence complementary to the DNA, where each “T” of the DNA sequence is substituted with “U.” 
     An open reading frame (ORF) is a continuous stretch of DNA or RNA beginning with a start codon (e.g., methionine (ATG or AUG)) and ending with a stop codon (e.g., TAA, TAG or TGA, or UAA, UAG or UGA). An ORF typically encodes a protein. It will be understood that the sequences disclosed herein may further comprise additional elements, e.g., 5′ and 3′ UTRs, but that those elements, unlike the ORF, need not necessarily be present in a vaccine of the present disclosure. 
     Variants 
     In some embodiments, an RNA of the present disclosure encodes a  Salmonella  antigen variant. Antigen or other polypeptide variants refers to molecules that differ in their amino acid sequence from a wild-type, native or reference sequence. The antigen/polypeptide variants may possess substitutions, deletions, and/or insertions at certain positions within the amino acid sequence, as compared to a native or reference sequence. Ordinarily, variants possess at least 50% identity to a wild-type, native or reference sequence. In some embodiments, variants share at least 80%, or at least 90% identity with a wild-type, native or reference sequence. 
     Variant antigens/polypeptides encoded by nucleic acids of the disclosure may contain amino acid changes that confer any of a number of desirable properties, e.g., that enhance their immunogenicity, enhance their expression, and/or improve their stability or PK/PD properties in a subject. Variant antigens/polypeptides can be made using routine mutagenesis techniques and assayed as appropriate to determine whether they possess the desired property. Assays to determine expression levels and immunogenicity are well known in the art and exemplary such assays are set forth in the Examples section. Similarly, PK/PD properties of a protein variant can be measured using art recognized techniques, e.g., by determining expression of antigens in a vaccinated subject over time and/or by looking at the durability of the induced immune response. The stability of protein(s) encoded by a variant nucleic acid may be measured by assaying thermal stability or stability upon urea denaturation or may be measured using in silico prediction. Methods for such experiments and in silico determinations are known in the art. 
     In some embodiments, a  Salmonella  vaccine comprises an mRNA ORF having a nucleotide sequence identified by any one of the sequences provided herein (see e.g., Sequence Listing and Tables 1-9 of the Examples section), or having a nucleotide sequence at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identical to a nucleotide sequence identified by any one of the sequence provided herein. 
     The term “identity” refers to a relationship between the sequences of two or more polypeptides (e.g. antigens) or polynucleotides (nucleic acids), as determined by comparing the sequences. Identity also refers to the degree of sequence relatedness between or among sequences as determined by the number of matches between strings of two or more amino acid residues or nucleic acid residues. Identity measures the percent of identical matches between the smaller of two or more sequences with gap alignments (if any) addressed by a particular mathematical model or computer program (e.g., “algorithms”). Identity of related antigens or nucleic acids can be readily calculated by known methods. “Percent (%) identity” as it applies to polypeptide or polynucleotide sequences is defined as the percentage of residues (amino acid residues or nucleic acid residues) in the candidate amino acid or nucleic acid sequence that are identical with the residues in the amino acid sequence or nucleic acid sequence of a second sequence after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent identity. Methods and computer programs for the alignment are well known in the art. It is understood that identity depends on a calculation of percent identity but may differ in value due to gaps and penalties introduced in the calculation. Generally, variants of a particular polynucleotide or polypeptide (e.g., antigen) have at least 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% but less than 100% sequence identity to that particular reference polynucleotide or polypeptide as determined by sequence alignment programs and parameters described herein and known to those skilled in the art. Such tools for alignment include those of the BLAST suite (Stephen F. Altschul, et al (1997), “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs”,  Nucleic Acids Res.  25:3389-3402). Another popular local alignment technique is based on the Smith-Waterman algorithm (Smith, T. F. &amp; Waterman, M. S. (1981) “Identification of common molecular subsequences.”  J. Mol. Biol.  147:195-197). A general global alignment technique based on dynamic programming is the Needleman-Wunsch algorithm (Needleman, S. B. &amp; Wunsch, C. D. (1970) “A general method applicable to the search for similarities in the amino acid sequences of two proteins.”  J. Mol. Biol.  48:443-453). More recently a Fast Optimal Global Sequence Alignment Algorithm (FOGSAA) has been developed that purportedly produces global alignment of nucleotide and protein sequences faster than other optimal global alignment methods, including the Needleman-Wunsch algorithm. 
     As such, polynucleotides encoding peptides or polypeptides containing substitutions, insertions and/or additions, deletions and covalent modifications with respect to reference sequences, in particular the polypeptide (e.g., antigen) sequences disclosed herein, are included within the scope of this disclosure. For example, sequence tags or amino acids, such as one or more lysines, can be added to peptide sequences (e.g., at the N-terminal or C-terminal ends). Sequence tags can be used for peptide detection, purification or localization. Lysines can be used to increase peptide solubility or to allow for biotinylation. Alternatively, amino acid residues located at the carboxy and amino terminal regions of the amino acid sequence of a peptide or protein may optionally be deleted providing for truncated sequences. Certain amino acids (e.g., C-terminal or N-terminal residues) may alternatively be deleted depending on the use of the sequence, as for example, expression of the sequence as part of a larger sequence which is soluble, or linked to a solid support. In some embodiments, sequences for (or encoding) signal sequences, termination sequences, transmembrane domains, linkers, multimerization domains (such as, e.g., foldon regions) and the like may be substituted with alternative sequences that achieve the same or a similar function. In some embodiments, cavities in the core of proteins can be filled to improve stability, e.g., by introducing larger amino acids. In other embodiments, buried hydrogen bond networks may be replaced with hydrophobic resides to improve stability. In yet other embodiments, glycosylation sites may be removed and replaced with appropriate residues. Such sequences are readily identifiable to one of skill in the art. It should also be understood that some of the sequences provided herein contain sequence tags or terminal peptide sequences (e.g., at the N-terminal or C-terminal ends) that may be deleted, for example, prior to use in the preparation of an RNA (e.g., mRNA) vaccine. 
     As recognized by those skilled in the art, protein fragments, functional protein domains, and homologous proteins are also considered to be within the scope of  Salmonella  antigens of interest. For example, provided herein is any protein fragment (meaning a polypeptide sequence at least one amino acid residue shorter than a reference antigen sequence but otherwise identical) of a reference protein, provided that the fragment is immunogenic and confers a protective immune response to the  Salmonella  pathogen. In addition to variants that are identical to the reference protein but are truncated, in some embodiments, an antigen includes 2, 3, 4, 5, 6, 7, 8, 9, 10, or more mutations, as shown in any of the sequences provided or referenced herein. Antigens/antigenic polypeptides can range in length from about 4, 6, or 8 amino acids to full length proteins. 
     Stabilizing Elements 
     Naturally-occurring eukaryotic mRNA molecules can contain stabilizing elements, including, but not limited to untranslated regions (UTR) at their 5′-end (5′ UTR) and/or at their 3′-end (3′ UTR), in addition to other structural features, such as a 5′-cap structure or a 3′-poly(A) tail. Both the 5′ UTR and the 3′ UTR are typically transcribed from the genomic DNA and are elements of the premature mRNA. Characteristic structural features of mature mRNA, such as the 5′-cap and the 3′-poly(A) tail are usually added to the transcribed (premature) mRNA during mRNA processing. 
     In some embodiments, a vaccine includes at least one RNA polynucleotide having an open reading frame encoding at least one antigenic polypeptide having at least one modification, at least one 5′ terminal cap, and is formulated within a lipid nanoparticle. 5′-capping of polynucleotides may be completed concomitantly during the in vitro-transcription reaction using the following chemical RNA cap analogs to generate the 5′-guanosine cap structure according to manufacturer protocols: 3′-O-Me-m7G(5′)ppp(5′) G [the ARCA cap]; G(5′)ppp(5′)A; G(5′)ppp(5′)G; m7G(5′)ppp(5′)A; m7G(5′)ppp(5′)G (New England BioLabs, Ipswich, Mass.). 5′-capping of modified RNA may be completed post-transcriptionally using a Vaccinia Virus Capping Enzyme to generate the “Cap 0” structure: m7G(5′)ppp(5′)G (New England BioLabs, Ipswich, Mass.). Cap 1 structure may be generated using both Vaccinia Virus Capping Enzyme and a 2′-O methyl-transferase to generate: m7G(5′)ppp(5′)G-2′-O-methyl. Cap 2 structure may be generated from the Cap 1 structure followed by the 2′-O-methylation of the 5′-antepenultimate nucleotide using a 2′-O methyl-transferase. Cap 3 structure may be generated from the Cap 2 structure followed by the 2′-O-methylation of the 5′-preantepenultimate nucleotide using a 2′-O methyl-transferase. Enzymes may be derived from a recombinant source. 
     The 3′-poly(A) tail is typically a stretch of adenine nucleotides added to the 3′-end of the transcribed mRNA. It can, in some instances, comprise up to about 400 adenine nucleotides. In some embodiments, the length of the 3′-poly(A) tail may be an essential element with respect to the stability of the individual mRNA. 
     In some embodiments, a vaccine includes at least one RNA polynucleotide having an open reading frame encoding at least one antigenic polypeptide having at least one modification, at least one 5′ terminal cap, and is formulated within a lipid nanoparticle. 5′-capping of polynucleotides may be completed concomitantly during the in vitro-transcription reaction using the following chemical RNA cap analogs to generate the 5′-guanosine cap structure according to manufacturer protocols: 3′-O-Me-m7G(5′)ppp(5′) G [the ARCA cap]; G(5′)ppp(5′)A; G(5′)ppp(5′)G; m7G(5′)ppp(5′)A; m7G(5′)ppp(5′)G (New England BioLabs, Ipswich, Mass.). 5′-capping of modified RNA may be completed post-transcriptionally using a Vaccinia Virus Capping Enzyme to generate the “Cap 0” structure: m7G(5′)ppp(5′)G (New England BioLabs, Ipswich, Mass.). Cap 1 structure may be generated using both Vaccinia Virus Capping Enzyme and a 2′-O methyl-transferase to generate: m7G(5′)ppp(5′)G-2′-O-methyl. Cap 2 structure may be generated from the Cap 1 structure followed by the 2′-O-methylation of the 5′-antepenultimate nucleotide using a 2′-O methyl-transferase. Cap 3 structure may be generated from the Cap 2 structure followed by the 2′-O-methylation of the 5′-preantepenultimate nucleotide using a 2′-O methyl-transferase. Enzymes may be derived from a recombinant source. 
     In some embodiments,  Salmonella  RNA vaccines may include one or more stabilizing elements. Stabilizing elements may include for instance a histone stem-loop. A stem-loop binding protein (SLBP), a 32 kDa protein has been identified. It is associated with the histone stem-loop at the 3′-end of the histone messages in both the nucleus and the cytoplasm. Its expression level is regulated by the cell cycle; it peaks during the S-phase, when histone mRNA levels are also elevated. The protein has been shown to be essential for efficient 3′-end processing of histone pre-mRNA by the U7 snRNP. SLBP continues to be associated with the stem-loop after processing, and then stimulates the translation of mature histone mRNAs into histone proteins in the cytoplasm. The RNA binding domain of SLBP is conserved through metazoa and protozoa; its binding to the histone stem-loop depends on the structure of the loop. The minimum binding site includes at least three nucleotides 5′ and two nucleotides 3′ relative to the stem-loop. 
     In some embodiments,  Salmonella  RNA vaccines include a coding region, at least one histone stem-loop, and optionally, a poly(A) sequence or polyadenylation signal. The poly(A) sequence or polyadenylation signal generally should enhance the expression level of the encoded protein. The encoded protein, in some embodiments, is not a histone protein, a reporter protein (e.g. Luciferase, GFP, EGFP, β-Galactosidase, EGFP), or a marker or selection protein (e.g. alpha-Globin, Galactokinase and Xanthine:guanine phosphoribosyl transferase (GPT)). 
     In some embodiments, the combination of a poly(A) sequence or polyadenylation signal and at least one histone stem-loop, even though both represent alternative mechanisms in nature, acts synergistically to increase the protein expression beyond the level observed with either of the individual elements. The synergistic effect of the combination of poly(A) and at least one histone stem-loop does not depend on the order of the elements or the length of the poly(A) sequence. 
     In some embodiments,  Salmonella  RNA vaccines do not comprise a histone downstream element (HDE). “Histone downstream element” (HDE) includes a purine-rich polynucleotide stretch of approximately 15 to 20 nucleotides 3′ of naturally occurring stem-loops, representing the binding site for the U7 snRNA, which is involved in processing of histone pre-mRNA into mature histone mRNA. In some embodiments, the nucleic acid does not include an intron. 
     In some embodiments,  Salmonella  RNA vaccines may or may not contain an enhancer and/or promoter sequence, which may be modified or unmodified or which may be activated or inactivated. In some embodiments, the histone stem-loop is generally derived from histone genes, and includes an intramolecular base pairing of two neighbored partially or entirely reverse complementary sequences separated by a spacer, consisting of a short sequence, which forms the loop of the structure. The unpaired loop region is typically unable to base pair with either of the stem loop elements. It occurs more often in RNA, as is a key component of many RNA secondary structures, but may be present in single-stranded DNA as well. Stability of the stem-loop structure generally depends on the length, number of mismatches or bulges, and base composition of the paired region. In some embodiments, wobble base pairing (non-Watson-Crick base pairing) may result. In some embodiments, the at least one histone stem-loop sequence comprises a length of 15 to 45 nucleotides. 
     In some embodiments,  Salmonella  RNA vaccines may have one or more AU-rich sequences removed. These sequences, sometimes referred to as AURES are destabilizing sequences found in the 3′UTR. The AURES may be removed from the RNA vaccines. Alternatively the AURES may remain in the RNA vaccine. 
     Signal Peptides 
     In some embodiments, a  Salmonella  vaccine comprises a RNA having an ORF that encodes a signal peptide fused to the  Salmonella  antigen. Signal peptides, comprising the N-terminal 15-60 amino acids of proteins, are typically needed for the translocation across the membrane on the secretory pathway and, thus, universally control the entry of most proteins both in eukaryotes and prokaryotes to the secretory pathway. In eukaryotes, the signal peptide of a nascent precursor protein (pre-protein) directs the ribosome to the rough endoplasmic reticulum (ER) membrane and initiates the transport of the growing peptide chain across it for processing. ER processing produces mature proteins, wherein the signal peptide is cleaved from precursor proteins, typically by a ER-resident signal peptidase of the host cell, or they remain uncleaved and function as a membrane anchor. A signal peptide may also facilitate the targeting of the protein to the cell membrane. 
     A signal peptide may have a length of 15-60 amino acids. For example, a signal peptide may have a length of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, or 60 amino acids. In some embodiments, a signal peptide has a length of 20-60, 25-60, 30-60, 35-60, 40-60, 45-60, 50-60, 55-60, 15-55, 20-55, 25-55, 30-55, 35-55, 40-55, 45-55, 50-55, 15-50, 20-50, 25-50, 30-50, 35-50, 40-50, 45-50, 15-45, 20-45, 25-45, 30-45, 35-45, 40-45, 15-40, 20-40, 25-40, 30-40, 35-40, 15-35, 20-35, 25-35, 30-35, 15-30, 20-30, 25-30, 15-25, 20-25, or 15-20 amino acids. 
     Signal peptides from heterologous genes (which regulate expression of genes other than  Salmonella  antigens in nature) are known in the art and can be tested for desired properties and then incorporated into a nucleic acid of the disclosure. In some embodiments, the signal peptide is a bovine prolactin signal peptide. For example, the bovine prolactin signal peptide may comprise sequence MDSKGSSQKGSRLLLLLVVSNLLLPQGVVG (SEQ ID NO:151). Other signal peptide sequences that may be used as provided herein include, without limitation, MDWTWILFLVAAATRVHS (SEQ ID NO: 152), METPAQLLFLLLLWLPDTTG (SEQ ID NO:1 53), MLGSNSGQRVVFTILLLLVAPAYS (SEQ ID NO: 154), MKCLLYLAFLFIGVNCA (SEQ ID NO: 155), and MWLVSLAIVTACAGA (SEQ ID NO: 156). 
     Fusion Proteins 
     In some embodiments, a  Salmonella  RNA vaccine of the present disclosure includes an RNA encoding an antigenic fusion protein. Thus, the encoded antigen or antigens may include two or more proteins (e.g., protein and/or protein fragment) joined together. Alternatively, the protein to which a protein antigen is fused does not promote a strong immune response to itself, but rather to the  Salmonella  antigen. Antigenic fusion proteins, in some embodiments, retain the functional property from each original protein. 
     Scaffold Moieties 
     The RNA (e.g., mRNA) vaccines as provided herein, in some embodiments, encode fusion proteins which comprise  Salmonella  antigens linked to scaffold moieties. In some embodiments, such scaffold moieties impart desired properties to an antigen encoded by a nucleic acid of the disclosure. For example scaffold proteins may improve the immunogenicity of an antigen, e.g., by altering the structure of the antigen, altering the uptake and processing of the antigen, and/or causing the antigen to bind to a binding partner. 
     In some embodiments, the scaffold moiety is protein that can self-assemble into protein nanoparticles that are highly symmetric, stable, and structurally organized, with diameters of 10-150 nm, a highly suitable size range for optimal interactions with various cells of the immune system. In some embodiments, viral proteins or virus-like particles can be used to form stable nanoparticle structures. Examples of such viral proteins are known in the art. For example, in some embodiments, the scaffold moiety is a hepatitis B surface antigen (HBsAg). HBsAg forms spherical particles with an average diameter of ˜22 nm and which lacked nucleic acid and hence are non-infectious (Lopez-Sagaseta, J. et al.  Computational and Structural Biotechnology Journal  14 (2016) 58-68). In some embodiments, the scaffold moiety is a hepatitis B core antigen (HBcAg) self-assembles into particles of 24-31 nm diameter, which resembled the viral cores obtained from HBV-infected human liver. HBcAg produced in self-assembles into two classes of differently sized nanoparticles of 300 Å and 360 Å diameter, corresponding to 180 or 240 protomers. In some embodiments a  Salmonella  antigen is fused to HBsAG or HBcAG to facilitate self-assembly of nanoparticles displaying the  Salmonella  antigen. 
     In other embodiments, bacterial protein platforms may be used. Non-limiting examples of these self-assembling proteins include ferritin, lumazine and encapsulin. 
     Ferritin is a protein whose main function is intracellular iron storage. Ferritin is made of 24 subunits, each composed of a four-alpha-helix bundle, that self-assemble in a quaternary structure with octahedral symmetry (Cho K. J. et al.  J Mol Biol.  2009; 390:83-98). Several high-resolution structures of ferritin have been determined, confirming that  Helicobacter pylori  ferritin is made of 24 identical protomers, whereas in animals, there are ferritin light and heavy chains that can assemble alone or combine with different ratios into particles of 24 subunits (Granier T. et al.  J Biol Inorg Chem.  2003; 8:105-111; Lawson D. M. et al.  Nature.  1991; 349:541-544). Ferritin self-assembles into nanoparticles with robust thermal and chemical stability. Thus, the ferritin nanoparticle is well-suited to carry and expose antigens. 
     Lumazine synthase (LS) is also well-suited as a nanoparticle platform for antigen display. LS, which is responsible for the penultimate catalytic step in the biosynthesis of riboflavin, is an enzyme present in a broad variety of organisms, including archaea, bacteria, fungi, plants, and eubacteria (Weber S. E.  Flavins and Flavoproteins . Methods and Protocols, Series: Methods in Molecular Biology. 2014). The LS monomer is 150 amino acids long, and consists of beta-sheets along with tandem alpha-helices flanking its sides. A number of different quaternary structures have been reported for LS, illustrating its morphological versatility: from homopentamers up to symmetrical assemblies of 12 pentamers forming capsids of 150 Å diameter. Even LS cages of more than 100 subunits have been described (Zhang X. et al.  J Mol Biol.  2006; 362:753-770). 
     Encapsulin, a novel protein cage nanoparticle isolated from thermophile  Thermotoga maritima , may also be used as a platform to present antigens on the surface of self-assembling nanoparticles. Encapsulin is assembled from 60 copies of identical 31 kDa monomers having a thin and icosahedral T=1 symmetric cage structure with interior and exterior diameters of 20 and 24 nm, respectively (Sutter M. et al.  Nat Struct Mol Biol.  2008, 15: 939-947). Although the exact function of encapsulin in  T. maritima  is not clearly understood yet, its crystal structure has been recently solved and its function was postulated as a cellular compartment that encapsulates proteins such as DyP (Dye decolorizing peroxidase) and Flp (Ferritin like protein), which are involved in oxidative stress responses (Rahmanpour R. et al.  FEBS J.  2013, 280: 2097-2104). 
     Linkers and Cleavable Peptides 
     In some embodiments, the mRNAs of the disclosure encode more than one polypeptide, referred to herein as fusion proteins. In some embodiments, the mRNA further encodes a linker located between at least one or each domain of the fusion protein. The linker can be, for example, a cleavable linker or protease-sensitive linker. In some embodiments, the linker is selected from the group consisting of F2A linker, P2A linker, T2A linker, E2A linker, and combinations thereof. This family of self-cleaving peptide linkers, referred to as 2A peptides, has been described in the art (see for example, Kim, J. H. et al. (2011)  PLoS ONE  6: e18556). In some embodiments, the linker is an F2A linker. In some embodiments, the linker is a GGGS linker. In some embodiments, the fusion protein contains three domains with intervening linkers, having the structure: domain-linker-domain-linker-domain. 
     Cleavable linkers known in the art may be used in connection with the disclosure. Exemplary such linkers include: F2A linkers, T2A linkers, P2A linkers, E2A linkers (See, e.g., WO2017127750). The skilled artisan will appreciate that other art-recognized linkers may be suitable for use in the constructs of the disclosure (e.g., encoded by the nucleic acids of the disclosure). The skilled artisan will likewise appreciate that other polycistronic constructs (mRNA encoding more than one antigen/polypeptide separately within the same molecule) may be suitable for use as provided herein. 
     Sequence Optimization 
     In some embodiments, an ORF encoding an antigen of the disclosure is codon optimized. Codon optimization methods are known in the art. For example, an ORF of any one or more of the sequences provided herein may be codon optimized. Codon optimization, in some embodiments, may be used to match codon frequencies in target and host organisms to ensure proper folding; bias GC content to increase mRNA stability or reduce secondary structures; minimize tandem repeat codons or base runs that may impair gene construction or expression; customize transcriptional and translational control regions; insert or remove protein trafficking sequences; remove/add post translation modification sites in encoded protein (e.g., glycosylation sites); add, remove or shuffle protein domains; insert or delete restriction sites; modify ribosome binding sites and mRNA degradation sites; adjust translational rates to allow the various domains of the protein to fold properly; or reduce or eliminate problem secondary structures within the polynucleotide. Codon optimization tools, algorithms and services are known in the art—non-limiting examples include services from GeneArt (Life Technologies), DNA2.0 (Menlo Park Calif.) and/or proprietary methods. In some embodiments, the open reading frame (ORF) sequence is optimized using optimization algorithms. 
     In some embodiments, a codon optimized sequence shares less than 95% sequence identity to a naturally-occurring or wild-type sequence ORF (e.g., a naturally-occurring or wild-type mRNA sequence encoding a  Salmonella  antigen). In some embodiments, a codon optimized sequence shares less than 90% sequence identity to a naturally-occurring or wild-type sequence (e.g., a naturally-occurring or wild-type mRNA sequence encoding a  Salmonella  antigen). In some embodiments, a codon optimized sequence shares less than 85% sequence identity to a naturally-occurring or wild-type sequence (e.g., a naturally-occurring or wild-type mRNA sequence encoding a  Salmonella  antigen). In some embodiments, a codon optimized sequence shares less than 80% sequence identity to a naturally-occurring or wild-type sequence (e.g., a naturally-occurring or wild-type mRNA sequence encoding a  Salmonella  antigen). In some embodiments, a codon optimized sequence shares less than 75% sequence identity to a naturally-occurring or wild-type sequence (e.g., a naturally-occurring or wild-type mRNA sequence encoding a  Salmonella  antigen). 
     In some embodiments, a codon optimized sequence shares between 65% and 85% (e.g., between about 67% and about 85% or between about 67% and about 80%) sequence identity to a naturally-occurring or wild-type sequence (e.g., a naturally-occurring or wild-type mRNA sequence encoding a  Salmonella  antigen). In some embodiments, a codon optimized sequence shares between 65% and 75% or about 80% sequence identity to a naturally-occurring or wild-type sequence (e.g., a naturally-occurring or wild-type mRNA sequence encoding a  Salmonella  antigen). 
     In some embodiments, a codon-optimized sequence encodes an antigen that is as immunogenic as, or more immunogenic than (e.g., at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 100%, or at least 200% more), than a  Salmonella  antigen encoded by a non-codon-optimized)sequence. 
     When transfected into mammalian cells, the modified mRNAs have a stability of between 12-18 hours, or greater than 18 hours, e.g., 24, 36, 48, 60, 72, or greater than 72 hours. 
     In some embodiments, a codon optimized RNA may be one in which the levels of G/C are enhanced. The G/C-content of nucleic acid molecules (e.g., mRNA) may influence the stability of the RNA. RNA having an increased amount of guanine (G) and/or cytosine (C) residues may be functionally more stable than RNA containing a large amount of adenine (A) and thymine (T) or uracil (U) nucleotides. As an example, WO02/098443 discloses a pharmaceutical composition containing an mRNA stabilized by sequence modifications in the translated region. Due to the degeneracy of the genetic code, the modifications work by substituting existing codons for those that promote greater RNA stability without changing the resulting amino acid. The approach is limited to coding regions of the RNA. 
     Chemically Unmodified Nucleotides 
     In some embodiments, at least one RNA (e.g., mRNA) of a  Salmonella  vaccines of the present disclosure is not chemically modified and comprises the standard ribonucleotides consisting of adenosine, guanosine, cytosine and uridine. In some embodiments, nucleotides and nucleosides of the present disclosure comprise standard nucleoside residues such as those present in transcribed RNA (e.g. A, G, C, or U). In some embodiments, nucleotides and nucleosides of the present disclosure comprise standard deoxyribonucleosides such as those present in DNA (e.g. dA, dG, dC, or dT). 
     Chemically Unmodified Nucleotides 
     In some embodiments, at least one RNA (e.g., mRNA) of a  almonella  vaccines of the present disclosure is not chemically modified and comprises the standard ribonucleotides consisting of adenosine, guanosine, cytosine and uridine. In some embodiments, nucleotides and nucleosides of the present disclosure comprise standard nucleoside residues such as those present in transcribed RNA (e.g. A, G, C, or U). In some embodiments, nucleotides and nucleosides of the present disclosure comprise standard deoxyribonucleosides such as those present in DNA (e.g. dA, dG, dC, or dT). 
     Chemical Modifications 
       Salmonella  RNA vaccines of the present disclosure comprise, in some embodiments, at least one nucleic acid (e.g., RNA) having an open reading frame encoding at least one  Salmonella  antigen, wherein the nucleic acid comprises nucleotides and/or nucleosides that can be standard (unmodified) or modified as is known in the art. In some embodiments, nucleotides and nucleosides of the present disclosure comprise modified nucleotides or nucleosides. Such modified nucleotides and nucleosides can be naturally-occurring modified nucleotides and nucleosides or non-naturally occurring modified nucleotides and nucleosides. Such modifications can include those at the sugar, backbone, or nucleobase portion of the nucleotide and/or nucleoside as are recognized in the art. 
     In some embodiments, a naturally-occurring modified nucleotide or nucleotide of the disclosure is one as is generally known or recognized in the art. Non-limiting examples of such naturally occurring modified nucleotides and nucleotides can be found, inter alia, in the widely recognized MODOMICS database. 
     In some embodiments, a non-naturally occurring modified nucleotide or nucleoside of the disclosure is one as is generally known or recognized in the art. Non-limiting examples of such non-naturally occurring modified nucleotides and nucleosides can be found, inter alia, in published US application Nos. PCT/US2012/058519; PCT/US2013/075177; PCT/US2014/058897; PCT/US2014/058891; PCT/US2014/070413; PCT/US2015/36773; PCT/US2015/36759; PCT/US2015/36771; or PCT/IB2017/051367 all of which are incorporated by reference herein. 
     Hence, nucleic acids of the disclosure (e.g., DNA nucleic acids and RNA nucleic acids, such as mRNA nucleic acids) can comprise standard nucleotides and nucleosides, naturally-occurring nucleotides and nucleosides, non-naturally-occurring nucleotides and nucleosides, or any combination thereof. 
     Nucleic acids of the disclosure (e.g., DNA nucleic acids and RNA nucleic acids, such as mRNA nucleic acids), in some embodiments, comprise various (more than one) different types of standard and/or modified nucleotides and nucleosides. In some embodiments, a particular region of a nucleic acid contains one, two or more (optionally different) types of standard and/or modified nucleotides and nucleosides. 
     In some embodiments, a modified RNA nucleic acid (e.g., a modified mRNA nucleic acid), introduced to a cell or organism, exhibits reduced degradation in the cell or organism, respectively, relative to an unmodified nucleic acid comprising standard nucleotides and nucleosides. 
     In some embodiments, a modified RNA nucleic acid (e.g., a modified mRNA nucleic acid), introduced into a cell or organism, may exhibit reduced immunogenicity in the cell or organism, respectively (e.g., a reduced innate response) relative to an unmodified nucleic acid comprising standard nucleotides and nucleosides. 
     Nucleic acids (e.g., RNA nucleic acids, such as mRNA nucleic acids), in some embodiments, comprise non-natural modified nucleotides that are introduced during synthesis or post-synthesis of the nucleic acids to achieve desired functions or properties. The modifications may be present on internucleotide linkages, purine or pyrimidine bases, or sugars. The modification may be introduced with chemical synthesis or with a polymerase enzyme at the terminal of a chain or anywhere else in the chain. Any of the regions of a nucleic acid may be chemically modified. 
     The present disclosure provides for modified nucleosides and nucleotides of a nucleic acid (e.g., RNA nucleic acids, such as mRNA nucleic acids). A “nucleoside” refers to a compound containing a sugar molecule (e.g., a pentose or ribose) or a derivative thereof in combination with an organic base (e.g., a purine or pyrimidine) or a derivative thereof (also referred to herein as “nucleobase”). A “nucleotide” refers to a nucleoside, including a phosphate group. Modified nucleotides may by synthesized by any useful method, such as, for example, chemically, enzymatically, or recombinantly, to include one or more modified or non-natural nucleosides. Nucleic acids can comprise a region or regions of linked nucleosides. Such regions may have variable backbone linkages. The linkages can be standard phosphodiester linkages, in which case the nucleic acids would comprise regions of nucleotides. 
     Modified nucleotide base pairing encompasses not only the standard adenosine-thymine, adenosine-uracil, or guanosine-cytosine base pairs, but also base pairs formed between nucleotides and/or modified nucleotides comprising non-standard or modified bases, wherein the arrangement of hydrogen bond donors and hydrogen bond acceptors permits hydrogen bonding between a non-standard base and a standard base or between two complementary non-standard base structures, such as, for example, in those nucleic acids having at least one chemical modification. One example of such non-standard base pairing is the base pairing between the modified nucleotide inosine and adenine, cytosine or uracil. Any combination of base/sugar or linker may be incorporated into nucleic acids of the present disclosure. 
     In some embodiments, modified nucleobases in nucleic acids (e.g., RNA nucleic acids, such as mRNA nucleic acids) comprise 1-methyl-pseudouridine (m1ψ), 1-ethyl-pseudouridine (e1ψ), 5-methoxy-uridine (mo5U), 5-methyl-cytidine (m5C), and/or pseudouridine (ψ). In some embodiments, modified nucleobases in nucleic acids (e.g., RNA nucleic acids, such as mRNA nucleic acids) comprise 5-methoxymethyl uridine, 5-methylthio uridine, 1-methoxymethyl pseudouridine, 5-methyl cytidine, and/or 5-methoxy cytidine. In some embodiments, the polyribonucleotide includes a combination of at least two (e.g., 2, 3, 4 or more) of any of the aforementioned modified nucleobases, including but not limited to chemical modifications. 
     In some embodiments, a RNA nucleic acid of the disclosure comprises 1-methyl-pseudouridine (m1ψ) substitutions at one or more or all uridine positions of the nucleic acid. 
     In some embodiments, a RNA nucleic acid of the disclosure comprises 1-methyl-pseudouridine (m1ψ) substitutions at one or more or all uridine positions of the nucleic acid and 5-methyl cytidine substitutions at one or more or all cytidine positions of the nucleic acid. 
     In some embodiments, a RNA nucleic acid of the disclosure comprises pseudouridine (ψ) substitutions at one or more or all uridine positions of the nucleic acid. 
     In some embodiments, a RNA nucleic acid of the disclosure comprises pseudouridine (ψ) substitutions at one or more or all uridine positions of the nucleic acid and 5-methyl cytidine substitutions at one or more or all cytidine positions of the nucleic acid. 
     In some embodiments, a RNA nucleic acid of the disclosure comprises uridine at one or more or all uridine positions of the nucleic acid. 
     In some embodiments, nucleic acids (e.g., RNA nucleic acids, such as mRNA nucleic acids) are uniformly modified (e.g., fully modified, modified throughout the entire sequence) for a particular modification. For example, a nucleic acid can be uniformly modified with 1-methyl-pseudouridine, meaning that all uridine residues in the mRNA sequence are replaced with 1-methyl-pseudouridine. Similarly, a nucleic acid can be uniformly modified for any type of nucleoside residue present in the sequence by replacement with a modified residue such as those set forth above. 
     The nucleic acids of the present disclosure may be partially or fully modified along the entire length of the molecule. For example, one or more or all or a given type of nucleotide (e.g., purine or pyrimidine, or any one or more or all of A, G, U, C) may be uniformly modified in a nucleic acid of the disclosure, or in a predetermined sequence region thereof (e.g., in the mRNA including or excluding the polyA tail). In some embodiments, all nucleotides X in a nucleic acid of the present disclosure (or in a sequence region thereof) are modified nucleotides, wherein X may be any one of nucleotides A, G, U, C, or any one of the combinations A+G, A+U, A+C, G+U, G+C, U+C, A+G+U, A+G+C, G+U+C or A+G+C. 
     The nucleic acid may contain from about 1% to about 100% modified nucleotides (either in relation to overall nucleotide content, or in relation to one or more types of nucleotide, i.e., any one or more of A, G, U or C) or any intervening percentage (e.g., from 1% to 20%, from 1% to 25%, from 1% to 50%, from 1% to 60%, from 1% to 70%, from 1% to 80%, from 1% to 90%, from 1% to 95%, from 10% to 20%, from 10% to 25%, from 10% to 50%, from 10% to 60%, from 10% to 70%, from 10% to 80%, from 10% to 90%, from 10% to 95%, from 10% to 100%, from 20% to 25%, from 20% to 50%, from 20% to 60%, from 20% to 70%, from 20% to 80%, from 20% to 90%, from 20% to 95%, from 20% to 100%, from 50% to 60%, from 50% to 70%, from 50% to 80%, from 50% to 90%, from 50% to 95%, from 50% to 100%, from 70% to 80%, from 70% to 90%, from 70% to 95%, from 70% to 100%, from 80% to 90%, from 80% to 95%, from 80% to 100%, from 90% to 95%, from 90% to 100%, and from 95% to 100%). It will be understood that any remaining percentage is accounted for by the presence of unmodified A, G, U, or C. 
     The nucleic acids may contain at a minimum 1% and at maximum 100% modified nucleotides, or any intervening percentage, such as at least 5% modified nucleotides, at least 10% modified nucleotides, at least 25% modified nucleotides, at least 50% modified nucleotides, at least 80% modified nucleotides, or at least 90% modified nucleotides. For example, the nucleic acids may contain a modified pyrimidine such as a modified uracil or cytosine. In some embodiments, at least 5%, at least 10%, at least 25%, at least 50%, at least 80%, at least 90% or 100% of the uracil in the nucleic acid is replaced with a modified uracil (e.g., a 5-substituted uracil). The modified uracil can be replaced by a compound having a single unique structure, or can be replaced by a plurality of compounds having different structures (e.g., 2, 3, 4 or more unique structures). In some embodiments, at least 5%, at least 10%, at least 25%, at least 50%, at least 80%, at least 90% or 100% of the cytosine in the nucleic acid is replaced with a modified cytosine (e.g., a 5-substituted cytosine). The modified cytosine can be replaced by a compound having a single unique structure, or can be replaced by a plurality of compounds having different structures (e.g., 2, 3, 4 or more unique structures). 
     Untranslated Regions (UTRs) 
     The nucleic acids of the present disclosure may comprise one or more regions or parts which act or function as an untranslated region. Where nucleic acids are designed to encode at least one antigen of interest, the nucleic may comprise one or more of these untranslated regions (UTRs). Wild-type untranslated regions of a nucleic acid are transcribed but not translated. In mRNA, the 5′ UTR starts at the transcription start site and continues to the start codon but does not include the start codon; whereas, the 3′ UTR starts immediately following the stop codon and continues until the transcriptional termination signal. There is growing body of evidence about the regulatory roles played by the UTRs in terms of stability of the nucleic acid molecule and translation. The regulatory features of a UTR can be incorporated into the polynucleotides of the present disclosure to, among other things, enhance the stability of the molecule. The specific features can also be incorporated to ensure controlled down-regulation of the transcript in case they are misdirected to undesired organs sites. A variety of 5′UTR and 3′UTR sequences are known and available in the art. 
     A 5′ UTR is region of an mRNA that is directly upstream (5′) from the start codon (the first codon of an mRNA transcript translated by a ribosome). A 5′ UTR does not encode a protein (is non-coding). Natural 5′UTRs have features that play roles in translation initiation. They harbor signatures like Kozak sequences which are commonly known to be involved in the process by which the ribosome initiates translation of many genes. Kozak sequences have the consensus CCR(A/G)CCAUGG (SEQ ID NO: 159), where R is a purine (adenine or guanine) three bases upstream of the start codon (AUG), which is followed by another ‘G’.5′UTR also have been known to form secondary structures which are involved in elongation factor binding. 
     In some embodiments of the disclosure, a 5′ UTR is a heterologous UTR, i.e., is a UTR found in nature associated with a different ORF. In another embodiment, a 5′ UTR is a synthetic UTR, i.e., does not occur in nature. Synthetic UTRs include UTRs that have been mutated to improve their properties, e.g., which increase gene expression as well as those which are completely synthetic. Exemplary 5′ UTRs include  Xenopus  or human derived a-globin or b-globin (U.S. Pat. Nos. 8,278,063; 9,012,219), human cytochrome b-245 a polypeptide, and hydroxysteroid (17b) dehydrogenase, and Tobacco etch virus (U.S. Pat. Nos. 8,278,063, 9,012,219). CMV immediate-early 1 (IE1) gene (US20140206753, WO2013/185069), the sequence GGGAUCCUACC (SEQ ID NO: 236) (WO2014144196) may also be used. In another embodiment, 5′ UTR of a TOP gene is a 5′ UTR of a TOP gene lacking the 5′ TOP motif (the oligopyrimidine tract) (e.g., WO/2015101414, WO2015101415, WO/2015/062738, WO2015024667, WO2015024667; 5′ UTR element derived from ribosomal protein Large 32 (L32) gene (WO/2015101414, WO2015101415, WO/2015/062738), 5′ UTR element derived from the 5′UTR of an hydroxysteroid (17-β) dehydrogenase 4 gene (HSD17B4) (WO2015024667), or a 5′ UTR element derived from the 5′ UTR of ATP5A1 (WO2015024667) can be used. In one embodiment, an internal ribosome entry site (IRES) is used instead of a 5′ UTR. 
     In some embodiments, a 5′ UTR of the present disclosure comprises a sequence selected from SEQ ID NO:3 and SEQ ID NO:140. 
     A 3′ UTR is region of an mRNA that is directly downstream (3′) from the stop codon (the codon of an mRNA transcript that signals a termination of translation). A 3′ UTR does not encode a protein (is non-coding). Natural or wild type 3′ UTRs are known to have stretches of adenosines and uridines embedded in them. These AU rich signatures are particularly prevalent in genes with high rates of turnover. Based on their sequence features and functional properties, the AU rich elements (AREs) can be separated into three classes (Chen et al, 1995): Class I AREs contain several dispersed copies of an AUUUA motif within U-rich regions. C-Myc and MyoD contain class I AREs. Class II AREs possess two or more overlapping UUAUUUA(U/A)(U/A) (SEQ ID NO: 160) nonamers. Molecules containing this type of AREs include GM-CSF and TNF-a. Class III ARES are less well defined. These U rich regions do not contain an AUUUA motif. c-Jun and Myogenin are two well-studied examples of this class. Most proteins binding to the AREs are known to destabilize the messenger, whereas members of the ELAV family, most notably HuR, have been documented to increase the stability of mRNA. HuR binds to AREs of all the three classes. Engineering the HuR specific binding sites into the 3′ UTR of nucleic acid molecules will lead to HuR binding and thus, stabilization of the message in vivo. 
     Introduction, removal or modification of 3′ UTR AU rich elements (AREs) can be used to modulate the stability of nucleic acids (e.g., RNA) of the disclosure. When engineering specific nucleic acids, one or more copies of an ARE can be introduced to make nucleic acids of the disclosure less stable and thereby curtail translation and decrease production of the resultant protein. Likewise, AREs can be identified and removed or mutated to increase the intracellular stability and thus increase translation and production of the resultant protein. Transfection experiments can be conducted in relevant cell lines, using nucleic acids of the disclosure and protein production can be assayed at various time points post-transfection. For example, cells can be transfected with different ARE-engineering molecules and by using an ELISA kit to the relevant protein and assaying protein produced at 6 hour, 12 hour, 24 hour, 48 hour, and 7 days post-transfection. 
     3′ UTRs may be heterologous or synthetic. With respect to 3′ UTRs, globin UTRs, including  Xenopus  β-globin UTRs and human β-globin UTRs are known in the art (U.S. Pat. Nos. 8,278,063, 9,012,219, US20110086907). A modified β-globin construct with enhanced stability in some cell types by cloning two sequential human β-globin 3′UTRs head to tail has been developed and is well known in the art (US2012/0195936, WO2014/071963). In addition a2-globin, a1-globin, UTRs and mutants thereof are also known in the art (WO2015101415, WO2015024667). Other 3′ UTRs described in the mRNA constructs in the non-patent literature include CYBA (Ferizi et al., 2015) and albumin (Thess et al., 2015). Other exemplary 3′ UTRs include that of bovine or human growth hormone (wild type or modified) (WO2013/185069, US20140206753, WO2014152774), rabbit β globin and hepatitis B virus (HBV), α-globin 3′ UTR and Viral VEEV 3′ UTR sequences are also known in the art. In some embodiments, the sequence UUUGAAUU (WO2014144196) is used. In some embodiments, 3′ UTRs of human and mouse ribosomal protein are used. Other examples include rps9 3′UTR (WO2015101414), FIG. 4 (WO2015101415), and human albumin 7 (WO2015101415). 
     In some embodiments, a 3′ UTR of the present disclosure comprises a sequence selected from SEQ ID NO:4 and SEQ ID NO:129, 
     Those of ordinary skill in the art will understand that 5′UTRs that are heterologous or synthetic may be used with any desired 3′ UTR sequence. For example, a heterologous 5′UTR may be used with a synthetic 3′UTR with a heterologous 3″ UTR. 
     Non-UTR sequences may also be used as regions or subregions within a nucleic acid. For example, introns or portions of introns sequences may be incorporated into regions of nucleic acid of the disclosure. Incorporation of intronic sequences may increase protein production as well as nucleic acid levels. 
     Combinations of features may be included in flanking regions and may be contained within other features. For example, the ORF may be flanked by a 5′ UTR which may contain a strong Kozak translational initiation signal and/or a 3′ UTR which may include an oligo(dT) sequence for templated addition of a poly-A tail. 5′ UTR may comprise a first polynucleotide fragment and a second polynucleotide fragment from the same and/or different genes such as the 5′ UTRs described in US Patent Application Publication No. 20100293625 and PCT/US2014/069155, herein incorporated by reference in its entirety. 
     It should be understood that any UTR from any gene may be incorporated into the regions of a nucleic acid. Furthermore, multiple wild-type UTRs of any known gene may be utilized. It is also within the scope of the present disclosure to provide artificial UTRs which are not variants of wild type regions. These UTRs or portions thereof may be placed in the same orientation as in the transcript from which they were selected or may be altered in orientation or location. Hence a 5′ or 3′ UTR may be inverted, shortened, lengthened, made with one or more other 5′ UTRs or 3′ UTRs. As used herein, the term “altered” as it relates to a UTR sequence, means that the UTR has been changed in some way in relation to a reference sequence. For example, a 3′ UTR or 5′ UTR may be altered relative to a wild-type or native UTR by the change in orientation or location as taught above or may be altered by the inclusion of additional nucleotides, deletion of nucleotides, swapping or transposition of nucleotides. Any of these changes producing an “altered” UTR (whether 3′ or 5′) comprise a variant UTR. 
     In some embodiments, a double, triple or quadruple UTR such as a 5′ UTR or 3′ UTR may be used. As used herein, a “double” UTR is one in which two copies of the same UTR are encoded either in series or substantially in series. For example, a double beta-globin 3′ UTR may be used as described in US Patent publication 20100129877, the contents of which are incorporated herein by reference in its entirety. 
     It is also within the scope of the present disclosure to have patterned UTRs. As used herein “patterned UTRs” are those UTRs which reflect a repeating or alternating pattern, such as ABABAB or AABBAABBAABB or ABCABCABC or variants thereof repeated once, twice, or more than 3 times. In these patterns, each letter, A, B, or C represent a different UTR at the nucleotide level. 
     In some embodiments, flanking regions are selected from a family of transcripts whose proteins share a common function, structure, feature or property. For example, polypeptides of interest may belong to a family of proteins which are expressed in a particular cell, tissue or at some time during development. The UTRs from any of these genes may be swapped for any other UTR of the same or different family of proteins to create a new polynucleotide. As used herein, a “family of proteins” is used in the broadest sense to refer to a group of two or more polypeptides of interest which share at least one function, structure, feature, localization, origin, or expression pattern. 
     The untranslated region may also include translation enhancer elements (TEE). As a non-limiting example, the TEE may include those described in US Application No. 20090226470, herein incorporated by reference in its entirety, and those known in the art. 
     In Vitro Transcription of RNA 
     cDNA encoding the polynucleotides described herein may be transcribed using an in vitro transcription (IVT) system. In vitro transcription of RNA is known in the art and is described in International Publication WO/2014/152027, which is incorporated by reference herein in its entirety. 
     In some embodiments, the RNA transcript is generated using a non-amplified, linearized DNA template in an in vitro transcription reaction to generate the RNA transcript. In some embodiments, the template DNA is isolated DNA. In some embodiments, the template DNA is cDNA. In some embodiments, the cDNA is formed by reverse transcription of a RNA polynucleotide, for example, but not limited to  Salmonella  RNA, e.g.  Salmonella  mRNA. In some embodiments, cells, e.g., bacterial cells, e.g.,  E. coli , e.g., DH-1 cells are transfected with the plasmid DNA template. In some embodiments, the transfected cells are cultured to replicate the plasmid DNA which is then isolated and purified. In some embodiments, the DNA template includes a RNA polymerase promoter, e.g., a T7 promoter located 5′ to and operably linked to the gene of interest. 
     In some embodiments, an in vitro transcription template encodes a 5′ untranslated (UTR) region, contains an open reading frame, and encodes a 3′ UTR and a polyA tail. The particular nucleic acid sequence composition and length of an in vitro transcription template will depend on the mRNA encoded by the template. 
     A “5′ untranslated region” (UTR) refers to a region of an mRNA that is directly upstream (i.e., 5′) from the start codon (i.e., the first codon of an mRNA transcript translated by a ribosome) that does not encode a polypeptide. When RNA transcripts are being generated, the 5′ UTR may comprise a promoter sequence. Such promoter sequences are known in the art. It should be understood that such promoter sequences will not be present in a vaccine of the disclosure. 
     A “3′ untranslated region” (UTR) refers to a region of an mRNA that is directly downstream (i.e., 3′) from the stop codon (i.e., the codon of an mRNA transcript that signals a termination of translation) that does not encode a polypeptide. 
     An “open reading frame” is a continuous stretch of DNA beginning with a start codon (e.g., methionine (ATG)), and ending with a stop codon (e.g., TAA, TAG or TGA) and encodes a polypeptide. 
     A “polyA tail” is a region of mRNA that is downstream, e.g., directly downstream (i.e., 3′), from the 3′ UTR that contains multiple, consecutive adenosine monophosphates. A polyA tail may contain 10 to 300 adenosine monophosphates. For example, a polyA tail may contain 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290 or 300 adenosine monophosphates. In some embodiments, a polyA tail contains 50 to 250 adenosine monophosphates. In a relevant biological setting (e.g., in cells, in vivo) the poly(A) tail functions to protect mRNA from enzymatic degradation, e.g., in the cytoplasm, and aids in transcription termination, and/or export of the mRNA from the nucleus and translation. 
     In some embodiments, a nucleic acid includes 200 to 3,000 nucleotides. For example, a nucleic acid may include 200 to 500, 200 to 1000, 200 to 1500, 200 to 3000, 500 to 1000, 500 to 1500, 500 to 2000, 500 to 3000, 1000 to 1500, 1000 to 2000, 1000 to 3000, 1500 to 3000, or 2000 to 3000 nucleotides). 
     An in vitro transcription system typically comprises a transcription buffer, nucleotide triphosphates (NTPs), an RNase inhibitor and a polymerase. 
     The NTPs may be manufactured in house, may be selected from a supplier, or may be synthesized as described herein. The NTPs may be selected from, but are not limited to, those described herein including natural and unnatural (modified) NTPs. 
     Any number of RNA polymerases or variants may be used in the method of the present disclosure. The polymerase may be selected from, but is not limited to, a phage RNA polymerase, e.g., a T7 RNA polymerase, a T3 RNA polymerase, a SP6 RNA polymerase, and/or mutant polymerases such as, but not limited to, polymerases able to incorporate modified nucleic acids and/or modified nucleotides, including chemically modified nucleic acids and/or nucleotides. Some embodiments exclude the use of DNase. 
     In some embodiments, the RNA transcript is capped via enzymatic capping. In some embodiments, the RNA comprises 5′ terminal cap, for example, 7mG(5′)ppp(5′)NlmpNp. 
     Chemical Synthesis 
     Solid-Phase Chemical Synthesis. 
     Nucleic acids the present disclosure may be manufactured in whole or in part using solid phase techniques. Solid-phase chemical synthesis of nucleic acids is an automated method wherein molecules are immobilized on a solid support and synthesized step by step in a reactant solution. Solid-phase synthesis is useful in site-specific introduction of chemical modifications in the nucleic acid sequences. 
     Liquid Phase Chemical Synthesis. 
     The synthesis of nucleic acids of the present disclosure by the sequential addition of monomer building blocks may be carried out in a liquid phase. 
     Combination of Synthetic Methods. 
     The synthetic methods discussed above each has its own advantages and limitations. Attempts have been conducted to combine these methods to overcome the limitations. Such combinations of methods are within the scope of the present disclosure. The use of solid-phase or liquid-phase chemical synthesis in combination with enzymatic ligation provides an efficient way to generate long chain nucleic acids that cannot be obtained by chemical synthesis alone. 
     Ligation of Nucleic Acid Regions or Subregions 
     Assembling nucleic acids by a ligase may also be used. DNA or RNA ligases promote intermolecular ligation of the 5′ and 3′ ends of polynucleotide chains through the formation of a phosphodiester bond. Nucleic acids such as chimeric polynucleotides and/or circular nucleic acids may be prepared by ligation of one or more regions or subregions. DNA fragments can be joined by a ligase catalyzed reaction to create recombinant DNA with different functions. Two oligodeoxynucleotides, one with a 5′ phosphoryl group and another with a free 3′ hydroxyl group, serve as substrates for a DNA ligase. 
     Purification 
     Purification of the nucleic acids described herein may include, but is not limited to, nucleic acid clean-up, quality assurance and quality control. Clean-up may be performed by methods known in the arts such as, but not limited to, AGENCOURT® beads (Beckman Coulter Genomics, Danvers, Mass.), poly-T beads, LNATM oligo-T capture probes (EXIQON® Inc, Vedbaek, Denmark) or HPLC based purification methods such as, but not limited to, strong anion exchange HPLC, weak anion exchange HPLC, reverse phase HPLC (RP-HPLC), and hydrophobic interaction HPLC (HIC-HPLC). The term “purified” when used in relation to a nucleic acid such as a “purified nucleic acid” refers to one that is separated from at least one contaminant. A “contaminant” is any substance that makes another unfit, impure or inferior. Thus, a purified nucleic acid (e.g., DNA and RNA) is present in a form or setting different from that in which it is found in nature, or a form or setting different from that which existed prior to subjecting it to a treatment or purification method. 
     A quality assurance and/or quality control check may be conducted using methods such as, but not limited to, gel electrophoresis, UV absorbance, or analytical HPLC. 
     In some embodiments, the nucleic acids may be sequenced by methods including, but not limited to reverse-transcriptase-PCR. 
     Quantification 
     In some embodiments, the nucleic acids of the present invention may be quantified in exosomes or when derived from one or more bodily fluid. Bodily fluids include peripheral blood, serum, plasma, ascites, urine, cerebrospinal fluid (CSF), sputum, saliva, bone marrow, synovial fluid, aqueous humor, amniotic fluid, cerumen, breast milk, broncheoalveolar lavage fluid, semen, prostatic fluid, cowper&#39;s fluid or pre-ejaculatory fluid, sweat, fecal matter, hair, tears, cyst fluid, pleural and peritoneal fluid, pericardial fluid, lymph, chyme, chyle, bile, interstitial fluid, menses, pus, sebum, vomit, vaginal secretions, mucosal secretion, stool water, pancreatic juice, lavage fluids from sinus cavities, bronchopulmonary aspirates, blastocyl cavity fluid, and umbilical cord blood. Alternatively, exosomes may be retrieved from an organ selected from the group consisting of lung, heart, pancreas, stomach, intestine, bladder, kidney, ovary, testis, skin, colon, breast, prostate, brain, esophagus, liver, and placenta. 
     Assays may be performed using construct specific probes, cytometry, qRT-PCR, real-time PCR, PCR, flow cytometry, electrophoresis, mass spectrometry, or combinations thereof while the exosomes may be isolated using immunohistochemical methods such as enzyme linked immunosorbent assay (ELISA) methods. Exosomes may also be isolated by size exclusion chromatography, density gradient centrifugation, differential centrifugation, nanomembrane ultrafiltration, immunoabsorbent capture, affinity purification, microfluidic separation, or combinations thereof. 
     These methods afford the investigator the ability to monitor, in real time, the level of nucleic acids remaining or delivered. This is possible because the nucleic acids of the present disclosure, in some embodiments, differ from the endogenous forms due to the structural or chemical modifications. 
     In some embodiments, the nucleic acid may be quantified using methods such as, but not limited to, ultraviolet visible spectroscopy (UV/Vis). A non-limiting example of a UV/Vis spectrometer is a NANODROP® spectrometer (ThermoFisher, Waltham, Mass.). The quantified nucleic acid may be analyzed in order to determine if the nucleic acid may be of proper size, check that no degradation of the nucleic acid has occurred. Degradation of the nucleic acid may be checked by methods such as, but not limited to, agarose gel electrophoresis, HPLC based purification methods such as, but not limited to, strong anion exchange HPLC, weak anion exchange HPLC, reverse phase HPLC (RP-HPLC), and hydrophobic interaction HPLC (HIC-HPLC), liquid chromatography-mass spectrometry (LCMS), capillary electrophoresis (CE) and capillary gel electrophoresis (CGE). 
     Pharmaceutical Formulations 
     Provided herein are compositions (e.g., pharmaceutical compositions), methods, kits and reagents for prevention or treatment of  Salmonella  in humans and other mammals, for example.  Salmonella  RNA (e.g., mRNA) vaccines can be used as therapeutic or prophylactic agents. They may be used in medicine to prevent and/or treat infectious disease. 
     In some embodiments, a  Salmonella  vaccine containing RNA polynucleotides as described herein can be administered to a subject (e.g., a mammalian subject, such as a human subject), and the RNA polynucleotides are translated in vivo to produce an antigenic polypeptide (antigen). 
     An “effective amount” of a  Salmonella  vaccine is based, at least in part, on the target tissue, target cell type, means of administration, physical characteristics of the RNA (e.g., length, nucleotide composition, and/or extent of modified nucleosides), other components of the vaccine, and other determinants, such as age, body weight, height, sex and general health of the subject. Typically, an effective amount of a  Salmonella  vaccine provides an induced or boosted immune response as a function of antigen production in the cell. In some embodiments, an effective amount of the  Salmonella  RNA vaccine containing RNA polynucleotides having at least one chemical modifications are more efficient than a composition containing a corresponding unmodified polynucleotide encoding the same antigen or a peptide antigen. Increased antigen production may be demonstrated by increased cell transfection (the percentage of cells transfected with the RNA vaccine), increased protein translation from the polynucleotide, decreased nucleic acid degradation (as demonstrated, for example, by increased duration of protein translation from a modified polynucleotide), or altered antigen specific immune response of the host cell. 
     The term “pharmaceutical composition” refers to the combination of an active agent with a carrier, inert or active, making the composition especially suitable for diagnostic or therapeutic use in vivo or ex vivo. A “pharmaceutically acceptable carrier,” after administered to or upon a subject, does not cause undesirable physiological effects. The carrier in the pharmaceutical composition must be “acceptable” also in the sense that it is compatible with the active ingredient and can be capable of stabilizing it. One or more solubilizing agents can be utilized as pharmaceutical carriers for delivery of an active agent. Examples of a pharmaceutically acceptable carrier include, but are not limited to, biocompatible vehicles, adjuvants, additives, and diluents to achieve a composition usable as a dosage form. Examples of other carriers include colloidal silicon oxide, magnesium stearate, cellulose, and sodium lauryl sulfate. Additional suitable pharmaceutical carriers and diluents, as well as pharmaceutical necessities for their use, are described in Remington&#39;s Pharmaceutical Sciences. 
     In some embodiments, RNA vaccines (including polynucleotides and their encoded polypeptides) in accordance with the present disclosure may be used for treatment or prevention of  Salmonella. Salmonella  RNA vaccines may be administered prophylactically or therapeutically as part of an active immunization scheme to healthy individuals or early in infection during the incubation phase or during active infection after onset of symptoms. In some embodiments, the amount of RNA vaccines of the present disclosure provided to a cell, a tissue or a subject may be an amount effective for immune prophylaxis. 
       Salmonella  RNA (e.g., mRNA) vaccines may be administrated with other prophylactic or therapeutic compounds. As a non-limiting example, a prophylactic or therapeutic compound may be an adjuvant or a booster. As used herein, when referring to a prophylactic composition, such as a vaccine, the term “booster” refers to an extra administration of the prophylactic (vaccine) composition. A booster (or booster vaccine) may be given after an earlier administration of the prophylactic composition. The time of administration between the initial administration of the prophylactic composition and the booster may be, but is not limited to, 1 minute, 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, 15 minutes, 20 minutes 35 minutes, 40 minutes, 45 minutes, 50 minutes, 55 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, 10 hours, 11 hours, 12 hours, 13 hours, 14 hours, 15 hours, 16 hours, 17 hours, 18 hours, 19 hours, 20 hours, 21 hours, 22 hours, 23 hours, 1 day, 36 hours, 2 days, 3 days, 4 days, 5 days, 6 days, 1 week, 10 days, 2 weeks, 3 weeks, 1 month, 2 months, 3 months, 4 months, 5 months, 6 months, 7 months, 8 months, 9 months, 10 months, 11 months, 1 year, 18 months, 2 years, 3 years, 4 years, 5 years, 6 years, 7 years, 8 years, 9 years, 10 years, 11 years, 12 years, 13 years, 14 years, 15 years, 16 years, 17 years, 18 years, 19 years, 20 years, 25 years, 30 years, 35 years, 40 years, 45 years, 50 years, 55 years, 60 years, 65 years, 70 years, 75 years, 80 years, 85 years, 90 years, 95 years or more than 99 years. In exemplary embodiments, the time of administration between the initial administration of the prophylactic composition and the booster may be, but is not limited to, 1 week, 2 weeks, 3 weeks, 1 month, 2 months, 3 months, 6 months or 1 year. 
     In some embodiments,  Salmonella  RNA vaccines may be administered intramuscularly, intranasally or intradermally, similarly to the administration of inactivated vaccines known in the art. 
     The  Salmonella  RNA vaccines may be utilized in various settings depending on the prevalence of the infection or the degree or level of unmet medical need. As a non-limiting example, the RNA vaccines may be utilized to treat and/or prevent a variety of infectious disease. RNA vaccines have superior properties in that they produce much larger antibody titers, better neutralizing immunity, produce more durable immune responses, and/or produce responses earlier than commercially available vaccines. 
     Provided herein are pharmaceutical compositions including  Salmonella  RNA vaccines and RNA vaccine compositions and/or complexes optionally in combination with one or more pharmaceutically acceptable excipients. 
       Salmonella  RNA (e.g., mRNA) vaccines may be formulated or administered alone or in conjunction with one or more other components. For instance,  Salmonella  RNA vaccines (vaccine compositions) may comprise other components including, but not limited to, adjuvants. 
     In some embodiments,  Salmonella  RNA vaccines do not include an adjuvant (they are adjuvant free). 
       Salmonella  RNA (e.g., mRNA) vaccines may be formulated or administered in combination with one or more pharmaceutically-acceptable excipients. In some embodiments, vaccine compositions comprise at least one additional active substances, such as, for example, a therapeutically-active substance, a prophylactically-active substance, or a combination of both. Vaccine compositions may be sterile, pyrogen-free or both sterile and pyrogen-free. General considerations in the formulation and/or manufacture of pharmaceutical agents, such as vaccine compositions, may be found, for example, in Remington: The Science and Practice of Pharmacy 21st ed., Lippincott Williams &amp; Wilkins, 2005 (incorporated herein by reference in its entirety). 
     In some embodiments,  Salmonella  RNA vaccines are administered to humans, human patients or subjects. For the purposes of the present disclosure, the phrase “active ingredient” generally refers to the RNA vaccines or the polynucleotides contained therein, for example, RNA polynucleotides (e.g., mRNA polynucleotides) encoding antigens. 
     Formulations of the vaccine compositions described herein may be prepared by any method known or hereafter developed in the art of pharmacology. In general, such preparatory methods include the step of bringing the active ingredient (e.g., mRNA polynucleotide) into association with an excipient and/or one or more other accessory ingredients, and then, if necessary and/or desirable, dividing, shaping and/or packaging the product into a desired single- or multi-dose unit. 
     Relative amounts of the active ingredient, the pharmaceutically acceptable excipient, and/or any additional ingredients in a pharmaceutical composition in accordance with the disclosure will vary, depending upon the identity, size, and/or condition of the subject treated and further depending upon the route by which the composition is to be administered. By way of example, the composition may comprise between 0.1% and 100%, e.g., between 0.5 and 50%, between 1-30%, between 5-80%, at least 80% (w/w) active ingredient. 
     In some embodiments,  Salmonella  RNA vaccines are formulated using one or more excipients to: (1) increase stability; (2) increase cell transfection; (3) permit the sustained or delayed release (e.g., from a depot formulation); (4) alter the biodistribution (e.g., target to specific tissues or cell types); (5) increase the translation of encoded protein in vivo; and/or (6) alter the release profile of encoded protein (antigen) in vivo. In addition to traditional excipients such as any and all solvents, dispersion media, diluents, or other liquid vehicles, dispersion or suspension aids, surface active agents, isotonic agents, thickening or emulsifying agents, preservatives, excipients can include, without limitation, lipidoids, liposomes, lipid nanoparticles, polymers, lipoplexes, core-shell nanoparticles, peptides, proteins, cells transfected with  Salmonella  RNA vaccines (e.g., for transplantation into a subject), hyaluronidase, nanoparticle mimics and combinations thereof. 
     Lipid Nanoparticles (LNPs) 
     In some embodiments,  Salmonella  RNA (e.g., mRNA) vaccines of the disclosure are formulated in a lipid nanoparticle (LNP). Lipid nanoparticles typically comprise ionizable cationic lipid, non-cationic lipid, sterol and PEG lipid components along with the nucleic acid cargo of interest. The lipid nanoparticles of the disclosure can be generated using components, compositions, and methods as are generally known in the art, see for example PCT/US2016/052352; PCT/US2016/068300; PCT/US2017/037551; PCT/US2015/027400; PCT/US2016/047406; PCT/US2016000129; PCT/US2016/014280; PCT/US2016/014280; PCT/US2017/038426; PCT/US2014/027077; PCT/US2014/055394; PCT/US2016/52117; PCT/US2012/069610; PCT/US2017/027492; PCT/US2016/059575 and PCT/US2016/069491 all of which are incorporated by reference herein in their entirety. 
     Vaccines of the present disclosure are typically formulated in lipid nanoparticle. In some embodiments, the lipid nanoparticle comprises at least one ionizable cationic lipid, at least one non-cationic lipid, at least one sterol, and/or at least one polyethylene glycol (PEG)-modified lipid. 
     In some embodiments, the lipid nanoparticle comprises a molar ratio of 20-60% ionizable cationic lipid. For example, the lipid nanoparticle may comprise a molar ratio of 20-50%, 20-40%, 20-30%, 30-60%, 30-50%, 30-40%, 40-60%, 40-50%, or 50-60% ionizable cationic lipid. In some embodiments, the lipid nanoparticle comprises a molar ratio of 20%, 30%, 40%, 50, or 60% ionizable cationic lipid. 
     In some embodiments, the lipid nanoparticle comprises a molar ratio of 5-25% non-cationic lipid. For example, the lipid nanoparticle may comprise a molar ratio of 5-20%, 5-15%, 5-10%, 10-25%, 10-20%, 10-25%, 15-25%, 15-20%, or 20-25% non-cationic lipid. In some embodiments, the lipid nanoparticle comprises a molar ratio of 5%, 10%, 15%, 20%, or 25% non-cationic lipid. 
     In some embodiments, the lipid nanoparticle comprises a molar ratio of 25-55% sterol. For example, the lipid nanoparticle may comprise a molar ratio of 25-50%, 25-45%, 25-40%, 25-35%, 25-30%, 30-55%, 30-50%, 30-45%, 30-40%, 30-35%, 35-55%, 35-50%, 35-45%, 35-40%, 40-55%, 40-50%, 40-45%, 45-55%, 45-50%, or 50-55% sterol. In some embodiments, the lipid nanoparticle comprises a molar ratio of 25%, 30%, 35%, 40%, 45%, 50%, or 55% sterol. 
     In some embodiments, the lipid nanoparticle comprises a molar ratio of 0.5-15% PEG-modified lipid. For example, the lipid nanoparticle may comprise a molar ratio of 0.5-10%, 0.5-5%, 1-15%, 1-10%, 1-5%, 2-15%, 2-10%, 2-5%, 5-15%, 5-10%, or 10-15%. In some embodiments, the lipid nanoparticle comprises a molar ratio of 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, or 15% PEG-modified lipid. 
     In some embodiments, the lipid nanoparticle comprises a molar ratio of 20-60% ionizable cationic lipid, 5-25% non-cationic lipid, 25-55% sterol, and 0.5-15% PEG-modified lipid. 
     In some embodiments, an ionizable cationic lipid of the disclosure comprises a compound of Formula (I): 
     
       
         
         
             
             
         
       
     
     or a salt or isomer thereof, wherein: 
     R 1  is selected from the group consisting of C 5-30  alkyl, C 5-20  alkenyl, —R*YR″, —YR″, and —R″M′R′; 
     R 2  and R 3  are independently selected from the group consisting of H, C 1-14  alkyl, C 2-14  alkenyl, —R*YR″, —YR″, and —R*OR″, or R 2  and R 3 , together with the atom to which they are attached, form a heterocycle or carbocycle; 
     R 4  is selected from the group consisting of a C 3-6    
     carbocycle, —(CH 2 ) n Q, —(CH 2 ) n CHQR, —CHQR, —CQ(R) 2 , and unsubstituted C 1-6  alkyl, where Q is selected from a carbocycle, heterocycle, —OR, —O(CH 2 ) n N(R) 2 , —C(O)OR, —OC(O)R, —CX 3 , —CX 2 H, —CXH 2 , —CN, —N(R) 2 , —C(O)N(R) 2 , —N(R)C(O)R, —N(R)S(O) 2 R, —N(R)C(O)N(R) 2 , —N(R)C(S)N(R) 2 , —N(R)R 8 , —O(CH 2 ) n OR, —N(R)C(═NR 9 )N(R) 2 , —N(R)C(═CHR 9 )N(R) 2 , —OC(O)N(R) 2 , —N(R)C(O)OR, —N(OR)C(O)R, —N(OR)S(O) 2 R, —N(OR)C(O)OR, —N(OR)C(O)N(R) 2 , —N(OR)C(S)N(R) 2 , —N(OR)C(═NR 9 )N(R) 2 , —N(OR)C(═CHR 9 )N(R) 2 , —C(═NR 9 )N(R) 2 , —C(═NR 9 )R, —C(O)N(R)O R, and —C(R)N(R) 2 C(O)OR, and each n is independently selected from 1, 2, 3, 4, and 5; 
     each R 5  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R 6  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     M and M′ are independently selected from —C(O)O—, —OC(O)—, —C(O)N(R′)—, 
     —N(R′)C(O)—, —C(O)—, —C(S)—, —C(S)S—, —SC(S)—, —CH(OH)—, —P(O)(OR′)O—, —S(O) 2 —, —S—S—, an aryl group, and a heteroaryl group; 
     R 7  is selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     R 8  is selected from the group consisting of C 3-6  carbocycle and heterocycle; 
     R 9  is selected from the group consisting of H, CN, NO 2 , C 1-6  alkyl, —OR, —S(O) 2 R, —S(O) 2 N(R) 2 , C 2-6  alkenyl, C 3-6  carbocycle and heterocycle; 
     each R is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R′ is independently selected from the group consisting of C 1-18  alkyl, C 2-18  alkenyl, —R*YR″, —YR″, and H; 
     each R″ is independently selected from the group consisting of C 3-14  alkyl and C 3-14  alkenyl; 
     each R* is independently selected from the group consisting of C 1-12  alkyl and C 2-12  alkenyl; 
     each Y is independently a C 3-6  carbocycle; 
     each X is independently selected from the group consisting of F, Cl, Br, and I; and 
     m is selected from 5, 6, 7, 8, 9, 10, 11, 12, and 13. 
     In some embodiments, a subset of compounds of Formula (I) includes those in which when R 4  is —(CH 2 ) n Q, —(CH 2 ) n CHQR, —CHQR, or —CQ(R) 2 , then (i) Q is not —N(R) 2  when n is 1, 2, 3, 4 or 5, or (ii) Q is not 5, 6, or 7-membered heterocycloalkyl when n is 1 or 2. 
     In some embodiments, another subset of compounds of Formula (I) includes those in which 
     R 1  is selected from the group consisting of C 5-30  alkyl, C 5-20  alkenyl, —R*YR″, —YR″, and —R″M′R′; 
     R 2  and R 3  are independently selected from the group consisting of H, C 1-14  alkyl, C 2-14  alkenyl, —R*YR″, —YR″, and —R*OR″, or R 2  and R 3 , together with the atom to which they are attached, form a heterocycle or carbocycle; 
     R 4  is selected from the group consisting of a C 3-6    
     carbocycle, —(CH 2 ) n Q, —(CH 2 ) n CHQR, —CHQR, —CQ(R) 2 , and unsubstituted C 1-6  alkyl, where Q is selected from a C 3-6  carbocycle, a 5- to 14-membered heteroaryl having one or more heteroatoms selected from N, O, and S, —OR,
 
—O(CH 2 ) n N(R) 2 , —C(O)OR, —OC(O)R, —CX 3 , —CX 2 H, —CXH 2 , —CN, —C(O)N(R) 2 , —N(R)C(O)R, —N(R)S(O) 2 R, —N(R)C(O)N(R) 2 , —N(R)C(S)N(R) 2 , —CRN(R) 2 C(O)OR, —N(R)R 8 , —O(CH 2 ) n OR, —N(R)C(═NR 9 )N(R) 2 , —N(R)C(═CHR 9 )N(R) 2 , —OC(O)N(R) 2 , —N(R)C(O)OR, —N(OR)C(O)R, —N(OR)S(O) 2 R, —N(OR)C(O)OR, —N(OR)C(O)N(R) 2 , —N(OR)C(S)N(R) 2 , —N(OR)C(═NR 9 )N(R) 2 , —N(OR)C(═CHR 9 )N(R) 2 , —C(═NR 9 )N(R) 2 , —C(═NR 9 )R, —C(O)N(R)OR, and a 5- to 14-membered heterocycloalkyl having one or more heteroatoms selected from N, O, and S which is substituted with one or more substituents selected from oxo (═O), OH, amino, mono- or di-alkylamino, and C 1-3  alkyl, and each n is independently selected from 1, 2, 3, 4, and 5;
 
     each R 5  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R 6  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     M and M′ are independently selected from —C(O)O—, —OC(O)—, —C(O)N(R′)—, —N(R′)C(O)—, —C(O)—, —C(S)—, —C(S)S—, —SC(S)—, —CH(OH)—, —P(O)(OR′)O—, —S(O) 2 —, —S—S—, an aryl group, and a heteroaryl group; 
     R 7  is selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     R 8  is selected from the group consisting of C 3-6  carbocycle and heterocycle; 
     R 9  is selected from the group consisting of H, CN, NO 2 , C 1-6  alkyl, —OR, —S(O) 2 R, —S(O) 2 N(R) 2 , C 2-6  alkenyl, C 3-6  carbocycle and heterocycle; 
     each R is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R′ is independently selected from the group consisting of C 1-18  alkyl, C 2-18  alkenyl, —R*YR″, —YR″, and H; 
     each R″ is independently selected from the group consisting of C 3-14  alkyl and C 3-14  alkenyl; 
     each R* is independently selected from the group consisting of C 1-12  alkyl and C 2-12  alkenyl; 
     each Y is independently a C 3-6  carbocycle; 
     each X is independently selected from the group consisting of F, Cl, Br, and I; and 
     m is selected from 5, 6, 7, 8, 9, 10, 11, 12, and 13, or salts or isomers thereof. 
     In some embodiments, another subset of compounds of Formula (I) includes those in which 
     R 1  is selected from the group consisting of C 5-30  alkyl, C 5-20  alkenyl, —R*YR″, —YR″, and —R″M′R′; 
     R 2  and R 3  are independently selected from the group consisting of H, C 1-14  alkyl, C 2-14  alkenyl, —R*YR″, —YR″, and —R*OR″, or R 2  and R 3 , together with the atom to which they are attached, form a heterocycle or carbocycle; 
     R 4  is selected from the group consisting of a C 3-6    
     carbocycle, —(CH 2 ) n Q, —(CH 2 ) n CHQR, —CHQR, —CQ(R) 2 , and unsubstituted C 1-6  alkyl, where Q is selected from a C 3-6  carbocycle, a 5- to 14-membered heterocycle having one or more heteroatoms selected from N, O, and S, —OR,
 
—O(CH 2 ) n N(R) 2 , —C(O)OR, —OC(O)R, —CX 3 , —CX 2 H, —CXH 2 , —CN, —C(O)N(R) 2 , —N(R)C(O)R, —N(R)S(O) 2 R, —N(R)C(O)N(R) 2 , —N(R)C(S)N(R) 2 , —CRN(R) 2 C(O)OR, —N(R)R 8 , —O(CH 2 ) n OR, —N(R)C(═NR 9 )N(R) 2 , —N(R)C(═CHR 9 )N(R) 2 , —OC(O)N(R) 2 , —N(R)C(O)OR, —N(OR)C(O)R, —N(OR)S(O) 2 R, —N(OR)C(O)OR, —N(OR)C(O)N(R) 2 , —N(OR)C(S)N(R) 2 , —N(OR)C(═NR 9 )N(R) 2 , —N(OR)C(═CHR 9 )N(R) 2 , —C(═NR 9 )R, —C(O)N(R)OR, and —C(═NR 9 )N(R) 2 , and each n is independently selected from 1, 2, 3, 4, and 5; and when Q is a 5- to 14-membered heterocycle and (i) R 4  is —(CH 2 ) n Q in which n is 1 or 2, or (ii) R 4  is —(CH 2 ) n CHQR in which n is 1, or (iii) R 4  is —CHQR, and —CQ(R) 2 , then Q is either a 5- to 14-membered heteroaryl or 8- to 14-membered heterocycloalkyl;
 
     each R 5  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R 6  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     M and M′ are independently selected from —C(O)O—, —OC(O)—, —C(O)N(R′)—, —N(R′)C(O)—, —C(O)—, —C(S)—, —C(S)S—, —SC(S)—, —CH(OH)—, —P(O)(OR′)O—, —S(O) 2 —, —S—S—, an aryl group, and a heteroaryl group; 
     R 7  is selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     R 8  is selected from the group consisting of C 3-6  carbocycle and heterocycle; 
     R 9  is selected from the group consisting of H, CN, NO 2 , C 1-6  alkyl, —OR, —S(O) 2 R, —S(O) 2 N(R) 2 , C 2-6  alkenyl, C 3-6  carbocycle and heterocycle; 
     each R is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R′ is independently selected from the group consisting of C 1-18  alkyl, C 2-18  alkenyl, —R*YR″, —YR″, and H; 
     each R″ is independently selected from the group consisting of C 3-14  alkyl and C 3-14  alkenyl; 
     each R* is independently selected from the group consisting of C 1-12  alkyl and C 2-12  alkenyl; 
     each Y is independently a C 3-6  carbocycle; 
     each X is independently selected from the group consisting of F, Cl, Br, and I; and 
     m is selected from 5, 6, 7, 8, 9, 10, 11, 12, and 13, or salts or isomers thereof. 
     In some embodiments, another subset of compounds of Formula (I) includes those in which 
     R 1  is selected from the group consisting of C 5-30  alkyl, C 5-20  alkenyl, —R*YR″, —YR″, and —R″M′R′; 
     R 2  and R 3  are independently selected from the group consisting of H, C 1-14  alkyl, C 2-14  alkenyl, —R*YR″, —YR″, and —R*OR″, or R 2  and R 3 , together with the atom to which they are attached, form a heterocycle or carbocycle; 
     R 4  is selected from the group consisting of a C 3-6    
     carbocycle, —(CH 2 ) n Q, —(CH 2 ) n CHQR, —CHQR, —CQ(R) 2 , and unsubstituted C 1-6  alkyl, where Q is selected from a C 3-6  carbocycle, a 5- to 14-membered heteroaryl having one or more heteroatoms selected from N, O, and S, —OR,
 
—O(CH 2 ) n N(R) 2 , —C(O)OR, —OC(O)R, —CX 3 , —CX 2 H, —CXH 2 , —CN, —C(O)N(R) 2 , —N(R)C(O)R, —N(R)S(O) 2 R, —N(R)C(O)N(R) 2 , —N(R)C(S)N(R) 2 , —CRN(R) 2 C(O)OR, —N(R)R 8 , —O(CH 2 ) n OR, —N(R)C(═NR 9 )N(R) 2 , —N(R)C(═CHR 9 )N(R) 2 , —OC(O)N(R) 2 , —N(R)C(O)OR, —N(OR)C(O)R, —N(OR)S(O) 2 R, —N(OR)C(O)OR, —N(OR)C(O)N(R) 2 , —N(OR)C(S)N(R) 2 , —N(OR)C(═NR 9 )N(R) 2 , —N(OR)C(═CHR 9 )N(R) 2 , —C(═NR 9 )R, —C(O)N(R)OR, and —C(═NR 9 )N(R) 2 , and each n is independently selected from 1, 2, 3, 4, and 5;
 
     each R 5  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R 6  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     M and M′ are independently selected from —C(O)O—, —OC(O)—, —C(O)N(R′)—, —N(R′)C(O)—, —C(O)—, —C(S)—, —C(S)S—, —SC(S)—, —CH(OH)—, —P(O)(OR′)O—, —S(O) 2 —, —S—S—, an aryl group, and a heteroaryl group; 
     R 7  is selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     R 8  is selected from the group consisting of C 3-6  carbocycle and heterocycle; 
     R 9  is selected from the group consisting of H, CN, NO 2 , C 1-6  alkyl, —OR, —S(O) 2 R, —S(O) 2 N(R) 2 , C 2-6  alkenyl, C 3-6  carbocycle and heterocycle; 
     each R is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R′ is independently selected from the group consisting of C 1-18  alkyl, C 2-18  alkenyl, —R*YR″, —YR″, and H; 
     each R″ is independently selected from the group consisting of C 3-14  alkyl and C 3-14  alkenyl; 
     each R* is independently selected from the group consisting of C 1-12  alkyl and C 2-12  alkenyl; 
     each Y is independently a C 3-6  carbocycle; 
     each X is independently selected from the group consisting of F, Cl, Br, and I; and 
     m is selected from 5, 6, 7, 8, 9, 10, 11, 12, and 13, or salts or isomers thereof. 
     In some embodiments, another subset of compounds of Formula (I) includes those in which 
     R 1  is selected from the group consisting of C 5-30  alkyl, C 5-20  alkenyl, —R*YR″, —YR″, and —R″M′R′; 
     R 2  and R 3  are independently selected from the group consisting of H, C 2-14  alkyl, C 2-14  alkenyl, —R*YR″, —YR″, and —R*OR″, or R 2  and R 3 , together with the atom to which they are attached, form a heterocycle or carbocycle; 
     R 4  is —(CH 2 ) n Q or —(CH 2 ) n CHQR, where Q is —N(R) 2 , and n is selected from 3, 4, and 5; 
     each R 5  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R 6  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     M and M′ are independently selected from —C(O)O—, —OC(O)—, —C(O)N(R′)—, —N(R′)C(O)—, —C(O)—, —C(S)—, —C(S)S—, —SC(S)—, —CH(OH)—, —P(O)(OR′)O—, —S(O) 2 —, —S—S—, an aryl group, and a heteroaryl group; 
     R 7  is selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R′ is independently selected from the group consisting of C 1-18  alkyl, C 2-18  alkenyl, —R*YR″, —YR″, and H; 
     each R″ is independently selected from the group consisting of C 3-14  alkyl and C 3-14  alkenyl; 
     each R* is independently selected from the group consisting of C 1-12  alkyl and C 1-12  alkenyl; 
     each Y is independently a C 3-6  carbocycle; 
     each X is independently selected from the group consisting of F, Cl, Br, and I; and 
     m is selected from 5, 6, 7, 8, 9, 10, 11, 12, and 13, or salts or isomers thereof. 
     In some embodiments, another subset of compounds of Formula (I) includes those in which 
     R 1  is selected from the group consisting of C 5-30  alkyl, C 5-20  alkenyl, —R*YR″, —YR″, and —R″M′R′; 
     R 2  and R 3  are independently selected from the group consisting of C 1-14  alkyl, C 2-14  alkenyl, —R*YR″, —YR″, and —R*OR″, or R 2  and R 3 , together with the atom to which they are attached, form a heterocycle or carbocycle; 
     R 4  is selected from the group consisting of —(CH 2 ) n Q, —(CH 2 ) n CHQR, —CHQR, and —CQ(R) 2 , where Q is —N(R) 2 , and n is selected from 1, 2, 3, 4, and 5; 
     each R 5  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R 6  is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     M and M′ are independently selected from —C(O)O—, —OC(O)—, —C(O)N(R′)—, —N(R′)C(O)—, —C(O)—, —C(S)—, —C(S)S—, —SC(S)—, —CH(OH)—, —P(O)(OR′)O—, —S(O) 2 —, —S—S—, an aryl group, and a heteroaryl group; 
     R 7  is selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R is independently selected from the group consisting of C 1-3  alkyl, C 2-3  alkenyl, and H; 
     each R′ is independently selected from the group consisting of C 1-18  alkyl, C 2-18  alkenyl, —R*YR″, —YR″, and H; 
     each R″ is independently selected from the group consisting of C 3-14  alkyl and C 3-14  alkenyl; 
     each R* is independently selected from the group consisting of C 1-12  alkyl and C 1-12  alkenyl; 
     each Y is independently a C 3-6  carbocycle; 
     each X is independently selected from the group consisting of F, Cl, Br, and I; and 
     m is selected from 5, 6, 7, 8, 9, 10, 11, 12, and 13, 
     or salts or isomers thereof. 
     In some embodiments, a subset of compounds of Formula (I) includes those of Formula (IA): 
     
       
         
         
             
             
         
       
     
     or a salt or isomer thereof, wherein 1 is selected from 1, 2, 3, 4, and 5; m is selected from 5, 6, 7, 8, and 9; M 1  is a bond or M′; R 4  is unsubstituted C 1-3  alkyl, or —(CH 2 ) n Q, in which Q is OH, —NHC(S)N(R) 2 , —NHC(O)N(R) 2 , —N(R)C(O)R, —N(R)S(O) 2 R, —N(R)R 8 , —NHC(═NR 9 )N(R) 2 , —NHC(═CHR 9 )N(R) 2 , —OC(O)N(R) 2 , —N(R)C(O)OR, heteroaryl or heterocycloalkyl; M and M′ are independently selected from —C(O)O—, —OC(O)—, —C(O)N(R′)—, —P(O)(OR′)O—, —S—S—, an aryl group, and a heteroaryl group; and R 2  and R 3  are independently selected from the group consisting of H, C 1-14  alkyl, and C 2-14  alkenyl. 
     In some embodiments, a subset of compounds of Formula (I) includes those of Formula (II): 
     
       
         
         
             
             
         
       
     
     or a salt or isomer thereof, wherein 1 is selected from 1, 2, 3, 4, and 5; M 1  is a bond or M′; R 4  is unsubstituted C 1-3  alkyl, or —(CH 2 ) n Q, in which n is 2, 3, or 4, and Q is
 
OH, —NHC(S)N(R) 2 , —NHC(O)N(R) 2 , —N(R)C(O)R, —N(R)S(O) 2 R, —N(R)R 8 , —NHC(═NR 9 )N(R) 2 , —NHC(═CHR 9 )N(R) 2 , —OC(O)N(R) 2 , —N(R)C(O)OR, heteroaryl or heterocycloalkyl; M and M′ are independently selected
 
from —C(O)O—, —OC(O)—, —C(O)N(R′)—, —P(O)(OR′)O—, —S—S—, an aryl group, and a heteroaryl group; and R 2  and R 3  are independently selected from the group consisting of H, C 1-14  alkyl, and C 2-14  alkenyl.
 
     In some embodiments, a subset of compounds of Formula (I) includes those of Formula (IIa), (IIb), (IIc), or (IIe): 
     
       
         
         
             
             
         
       
     
     or a salt or isomer thereof, wherein R 4  is as described herein. 
     In some embodiments, a subset of compounds of Formula (I) includes those of Formula (IId): 
     
       
         
         
             
             
         
       
     
     or a salt or isomer thereof, wherein n is 2, 3, or 4; and m, R′, R″, and R 2  through R 6  are as described herein. For example, each of R 2  and R 3  may be independently selected from the group consisting of C 5-14  alkyl and C 5-14  alkenyl. 
     In some embodiments, an ionizable cationic lipid of the disclosure comprises a compound having structure: 
     
       
         
         
             
             
         
       
     
     In some embodiments, an ionizable cationic lipid of the disclosure comprises a compound having structure: 
     
       
         
         
             
             
         
       
     
     In some embodiments, a non-cationic lipid of the disclosure comprises 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC), 1,2-dimyristoyl-sn-gly cero-phosphocholine (DMPC), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-diundecanoyl-sn-glycero-phosphocholine (DUPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1,2-di-O-octadecenyl-sn-glycero-3-phosphocholine (18:0 Diether PC), 1-oleoyl-2 cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine (OChemsPC), 1-hexadecyl-sn-glycero-3-phosphocholine (C16 Lyso PC), 1,2-dilinolenoyl-sn-glycero-3-phosphocholine, 1,2-diarachidonoyl-sn-glycero-3-phosphocholine, 1,2-didocosahexaenoyl-sn-glycero-3-phosphocholine, 1,2-diphytanoyl-sn-glycero-3-phosphoethanolamine (ME 16.0 PE), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine, 1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine, 1,2-dilinolenoyl-sn-glycero-3-phosphoethanolamine, 1,2-diarachidonoyl-sn-glycero-3-phosphoethanolamine, 1,2-didocosahexaenoyl-sn-glycero-3-phosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt (DOPG), sphingomyelin, and mixtures thereof. 
     In some embodiments, a PEG modified lipid of the disclosure comprises a PEG-modified phosphatidylethanolamine, a PEG-modified phosphatidic acid, a PEG-modified ceramide, a PEG-modified dialkylamine, a PEG-modified diacylglycerol, a PEG-modified dialkylglycerol, and mixtures thereof. In some embodiments, the PEG-modified lipid is PEG-DMG, PEG-c-DOMG (also referred to as PEG-DOMG), PEG-DSG and/or PEG-DPG. 
     In some embodiments, a sterol of the disclosure comprises cholesterol, fecosterol, sitosterol, ergosterol, campesterol, stigmasterol, bras sicasterol, tomatidine, ursolic acid, alpha-tocopherol, and mixtures thereof. 
     In some embodiments, a LNP of the disclosure comprises an ionizable cationic lipid of Compound 1, wherein the non-cationic lipid is DSPC, the structural lipid that is cholesterol, and the PEG lipid is PEG-DMG. 
     In some embodiments, a LNP of the disclosure comprises an N:P ratio of from about 2:1 to about 30:1. 
     In some embodiments, a LNP of the disclosure comprises an N:P ratio of about 6:1. 
     In some embodiments, a LNP of the disclosure comprises an N:P ratio of about 3:1. 
     In some embodiments, a LNP of the disclosure comprises a wt/wt ratio of the ionizable cationic lipid component to the RNA of from about 10:1 to about 100:1. 
     In some embodiments, a LNP of the disclosure comprises a wt/wt ratio of the ionizable cationic lipid component to the RNA of about 20:1. 
     In some embodiments, a LNP of the disclosure comprises a wt/wt ratio of the ionizable cationic lipid component to the RNA of about 10:1. 
     In some embodiments, a LNP of the disclosure has a mean diameter from about 50 nm to about 150 nm. 
     In some embodiments, a LNP of the disclosure has a mean diameter from about 70 nm to about 120 nm. 
     Multivalent Vaccines 
     The  Salmonella  vaccines, as provided herein, may include an RNA (e.g. mRNA) or multiple RNAs encoding two or more antigens of the same  Salmonella  species. In some embodiments, a  Salmonella  vaccine includes an RNA or multiple RNAs encoding two or more antigens selected from SseB, Mig14, OmpL, OmpC, OmpD, OmpF, IroN, CirA, FepA, T0937, FliC, PilL, PltB, PltA, CdtB, SlyB, STY1086 and STY0796 antigens. In some embodiments, the RNA (at least one RNA) of a  Salmonella  vaccine may encode 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, or more antigens. 
     In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a SseB antigen and a Mig14 antigen. 
     In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a OmpL, OmpC, OmpD, and OmpF antigens. 
     In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding IroN, CirA, and FepA antigens. 
     In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB and a CdtB antigen (which make up the toxin, e.g., in mutated form). In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, and a CdtB antigen and an additional  Salmonella  antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a SseB antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a Mig14 antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a OmpL antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a OmpC antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a OmpD antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a OmpF antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and an IroN antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a CirA antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a FepA antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a T0937 antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a FliC antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a PilL antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a SlyB antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a STY1086 antigen. In some embodiments, a  Salmonella  vaccine comprises at least one RNA encoding a PltA, a PltB, a CdtB and a STY0796 antigen. 
     In some embodiments, two or more different RNA (e.g., mRNA) encoding antigens may be formulated in the same lipid nanoparticle. In other embodiments, two or more different RNA encoding antigens may be formulated in separate lipid nanoparticles (each RNA formulated in a single lipid nanoparticle). The lipid nanoparticles may then be combined and administered as a single vaccine composition (e.g., comprising multiple RNA encoding multiple antigens) or may be administered separately. 
     Combination Vaccines 
     The  Salmonella  vaccines, as provided herein, may include an RNA or multiple RNAs encoding two or more antigens of the same or different  Salmonella  species. Also provided herein are combination vaccines that include RNA encoding one or more  Salmonella  antigen(s) and one or more antigen(s) of a different organisms (e.g., bacterial and/or viral organism). Thus, the vaccines of the present disclosure may be combination vaccines that target one or more antigens of the same species, or one or more antigens of different species, e.g., antigens which induce immunity to organisms which are found in the same geographic areas where the risk of  Salmonella  infection is high or organisms to which an individual is likely to be exposed to when exposed to  Salmonella.    
     Dosing/Administration 
     Provided herein are compositions (e.g., pharmaceutical compositions), methods, kits and reagents for prevention and/or treatment of  Salmonella  in humans and other mammals.  Salmonella  RNA vaccines can be used as therapeutic or prophylactic agents. In some aspects, the RNA vaccines of the disclosure are used to provide prophylactic protection from  Salmonella . In some aspects, the RNA vaccines of the disclosure are used to treat a  Salmonella  infection. In some embodiments, the  Salmonella  vaccines of the present disclosure are used in the priming of immune effector cells, for example, to activate peripheral blood mononuclear cells (PBMCs) ex vivo, which are then infused (re-infused) into a subject. 
     A subject may be any mammal, including non-human primate and human subjects. Typically, a subject is a human subject. 
     In some embodiments, the  Salmonella  vaccines are administered to a subject (e.g., a mammalian subject, such as a human subject) in an effective amount to induce an antigen-specific immune response. The RNA encoding the  Salmonella  antigen is expressed and translated in vivo to produce the antigen, which then stimulates an immune response in the subject. 
     Prophylactic protection from  Salmonella  can be achieved following administration of a  Salmonella  RNA vaccine of the present disclosure. Vaccines can be administered once, twice, three times, four times or more but it is likely sufficient to administer the vaccine once (optionally followed by a single booster). It is possible, although less desirable, to administer the vaccine to an infected individual to achieve a therapeutic response. Dosing may need to be adjusted accordingly. 
     A method of eliciting an immune response in a subject against  Salmonella  is provided in aspects of the present disclosure. The method involves administering to the subject a  Salmonella  RNA vaccine comprising at least one RNA (e.g., mRNA) having an open reading frame encoding at least one  Salmonella  antigen, thereby inducing in the subject an immune response specific to  Salmonella  antigen, wherein anti-antigen antibody titer in the subject is increased following vaccination relative to anti-antigen antibody titer in a subject vaccinated with a prophylactically effective dose of a traditional vaccine against the  Salmonella . An “anti-antigen antibody” is a serum antibody the binds specifically to the antigen. 
     A prophylactically effective dose is an effective dose that prevents infection with the bacteria at a clinically acceptable level. In some embodiments, the effective dose is a dose listed in a package insert for the vaccine. A traditional vaccine, as used herein, refers to a vaccine other than the mRNA vaccines of the present disclosure. For instance, a traditional vaccine includes, but is not limited, to live microorganism vaccines, killed microorganism vaccines, subunit vaccines, protein antigen vaccines, DNA vaccines, virus like particle (VLP) vaccines, etc. In exemplary embodiments, a traditional vaccine is a vaccine that has achieved regulatory approval and/or is registered by a national drug regulatory body, for example the Food and Drug Administration (FDA) in the United States or the European Medicines Agency (EMA). 
     In some embodiments, the anti-antigen antibody titer in the subject is increased 1 log to 10 log following vaccination relative to anti-antigen antibody titer in a subject vaccinated with a prophylactically effective dose of a traditional vaccine against the  Salmonella  or an unvaccinated subject. In some embodiments, the anti-antigen antibody titer in the subject is increased 1 log, 2 log, 3 log, 4 log, 5 log, or 10 log following vaccination relative to anti-antigen antibody titer in a subject vaccinated with a prophylactically effective dose of a traditional vaccine against the  Salmonella  or an unvaccinated subject. 
     A method of eliciting an immune response in a subject against a  Salmonella  is provided in other aspects of the disclosure. The method involves administering to the subject a  Salmonella  RNA vaccine comprising at least one RNA polynucleotide having an open reading frame encoding at least one  Salmonella  antigen, thereby inducing in the subject an immune response specific to  Salmonella  antigen, wherein the immune response in the subject is equivalent to an immune response in a subject vaccinated with a traditional vaccine against the  Salmonella  at 2 times to 100 times the dosage level relative to the RNA vaccine. 
     In some embodiments, the immune response in the subject is equivalent to an immune response in a subject vaccinated with a traditional vaccine at twice the dosage level relative to the  Salmonella  RNA vaccine. In some embodiments, the immune response in the subject is equivalent to an immune response in a subject vaccinated with a traditional vaccine at three times the dosage level relative to the  Salmonella  RNA vaccine. In some embodiments, the immune response in the subject is equivalent to an immune response in a subject vaccinated with a traditional vaccine at 4 times, 5 times, 10 times, 50 times, or 100 times the dosage level relative to the  Salmonella  RNA vaccine. In some embodiments, the immune response in the subject is equivalent to an immune response in a subject vaccinated with a traditional vaccine at 10 times to 1000 times the dosage level relative to the  Salmonella  RNA vaccine. In some embodiments, the immune response in the subject is equivalent to an immune response in a subject vaccinated with a traditional vaccine at 100 times to 1000 times the dosage level relative to the  Salmonella  RNA vaccine. 
     In other embodiments, the immune response is assessed by determining [protein] antibody titer in the subject. 
     Other aspects the disclosure provide methods of eliciting an immune response in a subject against a  Salmonella  by administering to the subject a  Salmonella  RNA vaccine comprising at least one RNA polynucleotide having an open reading frame encoding at least one  Salmonella  antigen, thereby inducing in the subject an immune response specific to  Salmonella  antigen, wherein the immune response in the subject is induced 2 days to 10 weeks earlier relative to an immune response induced in a subject vaccinated with a prophylactically effective dose of a traditional vaccine against the  Salmonella . In some embodiments, the immune response in the subject is induced in a subject vaccinated with a prophylactically effective dose of a traditional vaccine at 2 times to 100 times the dosage level relative to the RNA vaccine. 
     In some embodiments, the immune response in the subject is induced 2 days, 3 days, 1 week, 2 weeks, 3 weeks, 5 weeks, or 10 weeks earlier relative to an immune response induced in a subject vaccinated with a prophylactically effective dose of a traditional vaccine. 
     Also provided herein are methods of eliciting an immune response in a subject against a  Salmonella  by administering to the subject a  Salmonella  RNA vaccine having an open reading frame encoding a first antigen, wherein the RNA polynucleotide does not include a stabilization element, and wherein an adjuvant is not co-formulated or co-administered with the vaccine. 
       Salmonella  RNA (e.g., mRNA) vaccines may be administered by any route which results in a therapeutically effective outcome. These include, but are not limited, to intradermal, intramuscular, intranasal, and/or subcutaneous administration. The present disclosure provides methods comprising administering RNA vaccines to a subject in need thereof. The exact amount required will vary from subject to subject, depending on the species, age, and general condition of the subject, the severity of the disease, the particular composition, its mode of administration, its mode of activity, and the like.  Salmonella  RNA (e.g., mRNA) vaccines compositions are typically formulated in dosage unit form for ease of administration and uniformity of dosage. It will be understood, however, that the total daily usage of  Salmonella  RNA (e.g., mRNA)vaccines compositions may be decided by the attending physician within the scope of sound medical judgment. The specific therapeutically effective, prophylactically effective, or appropriate imaging dose level for any particular patient will depend upon a variety of factors including the disorder being treated and the severity of the disorder; the activity of the specific compound employed; the specific composition employed; the age, body weight, general health, sex and diet of the patient; the time of administration, route of administration, and rate of excretion of the specific compound employed; the duration of the treatment; drugs used in combination or coincidental with the specific compound employed; and like factors well known in the medical arts. 
     The effective amount of a  Salmonella  vaccine, as provided herein, may be as low as 20 μg, administered for example as a single dose or as two 10 μg doses. In some embodiments, the effective amount is a total dose of 20 μg-200 μg. For example, the effective amount may be a total dose of 20 μg, 25 μg, 30 μg, 35 μg, 40 μg, 45 μg, 50 μg, 55 μg, 60 μg, 65 μg, 70 μg, 75 μg, 80 μg, 85 μg, 90 μg, 95 μg, 100 μg, 110 μg, 120 μg, 130 μg, 140 μg, 150 μg, 160 μg, 170 μg, 180 μg, 190 μg or 200 μg. In some embodiments, the effective amount is a total dose of 25 μg-200 μg. In some embodiments, the effective amount is a total dose of 50 μg-200 μg. 
     In some embodiments,  Salmonella  RNA (e.g., mRNA) vaccines compositions may be administered at dosage levels sufficient to deliver 0.0001 mg/kg to 100 mg/kg, 0.001 mg/kg to 0.05 mg/kg, 0.005 mg/kg to 0.05 mg/kg, 0.001 mg/kg to 0.005 mg/kg, 0.05 mg/kg to 0.5 mg/kg, 0.01 mg/kg to 50 mg/kg, 0.1 mg/kg to 40 mg/kg, 0.5 mg/kg to 30 mg/kg, 0.01 mg/kg to 10 mg/kg, 0.1 mg/kg to 10 mg/kg, or 1 mg/kg to 25 mg/kg, of subject body weight per day, one or more times a day, per week, per month, etc. to obtain the desired therapeutic, diagnostic, prophylactic, or imaging effect (see e.g., the range of unit doses described in International Publication No. WO2013078199, herein incorporated by reference in its entirety). The desired dosage may be delivered three times a day, two times a day, once a day, every other day, every third day, every week, every two weeks, every three weeks, every four weeks, every 2 months, every three months, every 6 months, etc. In certain embodiments, the desired dosage may be delivered using multiple administrations (e.g., two, three, four, five, six, seven, eight, nine, ten, eleven, twelve, thirteen, fourteen, or more administrations). When multiple administrations are employed, split dosing regimens such as those described herein may be used. In exemplary embodiments,  Salmonella  RNA (e.g., mRNA) vaccines compositions may be administered at dosage levels sufficient to deliver 0.0005 mg/kg to 0.01 mg/kg, e.g., about 0.0005 mg/kg to about 0.0075 mg/kg, e.g., about 0.0005 mg/kg, about 0.001 mg/kg, about 0.002 mg/kg, about 0.003 mg/kg, about 0.004 mg/kg or about 0.005 mg/kg. 
     In some embodiments,  Salmonella  RNA (e.g., mRNA) vaccine compositions may be administered once or twice (or more) at dosage levels sufficient to deliver 0.025 mg/kg to 0.250 mg/kg, 0.025 mg/kg to 0.500 mg/kg, 0.025 mg/kg to 0.750 mg/kg, or 0.025 mg/kg to 1.0 mg/kg. 
     In some embodiments,  Salmonella  RNA (e.g., mRNA) vaccine compositions may be administered twice (e.g., Day 0 and Day 7, Day 0 and Day 14, Day 0 and Day 21, Day 0 and Day 28, Day 0 and Day 60, Day 0 and Day 90, Day 0 and Day 120, Day 0 and Day 150, Day 0 and Day 180, Day 0 and 3 months later, Day 0 and 6 months later, Day 0 and 9 months later, Day 0 and 12 months later, Day 0 and 18 months later, Day 0 and 2 years later, Day 0 and 5 years later, or Day 0 and 10 years later) at a total dose of or at dosage levels sufficient to deliver a total dose of 0.0100 mg, 0.025 mg, 0.050 mg, 0.075 mg, 0.100 mg, 0.125 mg, 0.150 mg, 0.175 mg, 0.200 mg, 0.225 mg, 0.250 mg, 0.275 mg, 0.300 mg, 0.325 mg, 0.350 mg, 0.375 mg, 0.400 mg, 0.425 mg, 0.450 mg, 0.475 mg, 0.500 mg, 0.525 mg, 0.550 mg, 0.575 mg, 0.600 mg, 0.625 mg, 0.650 mg, 0.675 mg, 0.700 mg, 0.725 mg, 0.750 mg, 0.775 mg, 0.800 mg, 0.825 mg, 0.850 mg, 0.875 mg, 0.900 mg, 0.925 mg, 0.950 mg, 0.975 mg, or 1.0 mg. Higher and lower dosages and frequency of administration are encompassed by the present disclosure. For example, a  Salmonella  RNA (e.g., mRNA) vaccine composition may be administered three or four times. 
     In some embodiments,  Salmonella  RNA (e.g., mRNA) vaccine compositions may be administered twice (e.g., Day 0 and Day 7, Day 0 and Day 14, Day 0 and Day 21, Day 0 and Day 28, Day 0 and Day 60, Day 0 and Day 90, Day 0 and Day 120, Day 0 and Day 150, Day 0 and Day 180, Day 0 and 3 months later, Day 0 and 6 months later, Day 0 and 9 months later, Day 0 and 12 months later, Day 0 and 18 months later, Day 0 and 2 years later, Day 0 and 5 years later, or Day 0 and 10 years later) at a total dose of or at dosage levels sufficient to deliver a total dose of 0.010 mg, 0.025 mg, 0.100 mg or 0.400 mg. 
     In some embodiments, the  Salmonella  RNA (e.g., mRNA) vaccine for use in a method of vaccinating a subject is administered the subject a single dosage of between 10 μg/kg and 400 μg/kg of the nucleic acid vaccine in an effective amount to vaccinate the subject. In some embodiments, the RNA vaccine for use in a method of vaccinating a subject is administered the subject a single dosage of between 10 μg and 400 μg of the nucleic acid vaccine in an effective amount to vaccinate the subject. In some embodiments, a  Salmonella  RNA (e.g., mRNA) vaccine for use in a method of vaccinating a subject is administered to the subject as a single dosage of 25-1000 μg (e.g., a single dosage of mRNA encoding an  Salmonella  antigen). In some embodiments, a  Salmonella  RNA vaccine is administered to the subject as a single dosage of 25, 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950 or 1000 μg. For example, a  Salmonella  RNA vaccine may be administered to a subject as a single dose of 25-100, 25-500, 50-100, 50-500, 50-1000, 100-500, 100-1000, 250-500, 250-1000, or 500-1000 μg. In some embodiments, a  Salmonella  RNA (e.g., mRNA) vaccine for use in a method of vaccinating a subject is administered to the subject as two dosages, the combination of which equals 25-1000 μg of the  Salmonella  RNA (e.g., mRNA) vaccine. 
     A  Salmonella  RNA (e.g., mRNA) vaccine pharmaceutical composition described herein can be formulated into a dosage form described herein, such as an intranasal, intratracheal, or injectable (e.g., intravenous, intraocular, intravitreal, intramuscular, intradermal, intracardiac, intraperitoneal, and subcutaneous). 
     Vaccine Efficacy 
     Some aspects of the present disclosure provide formulations of the  Salmonella  RNA (e.g., mRNA) vaccine, wherein the  Salmonella  RNA vaccine is formulated in an effective amount to produce an antigen specific immune response in a subject (e.g., production of antibodies specific to an anti- Salmonella  antigen). “An effective amount” is a dose of an  Salmonella  RNA (e.g., mRNA) vaccine effective to produce an antigen-specific immune response. Also provided herein are methods of inducing an antigen-specific immune response in a subject. 
     As used herein, an immune response to a vaccine or LNP of the present invention is the development in a subject of a humoral and/or a cellular immune response to a (one or more)  Salmonella  protein(s) present in the vaccine. For purposes of the present invention, a “humoral” immune response refers to an immune response mediated by antibody molecules, including, e.g., secretory (IgA) or IgG molecules, while a “cellular” immune response is one mediated by T-lymphocytes (e.g., CD4+ helper and/or CD8+ T cells (e.g., CTLs) and/or other white blood cells. One important aspect of cellular immunity involves an antigen-specific response by cytolytic T-cells (CTLs). CTLs have specificity for peptide antigens that are presented in association with proteins encoded by the major histocompatibility complex (MHC) and expressed on the surfaces of cells. CTLs help induce and promote the destruction of intracellular microbes or the lysis of cells infected with such microbes. Another aspect of cellular immunity involves and antigen-specific response by helper T-cells. Helper T-cells act to help stimulate the function, and focus the activity nonspecific effector cells against cells displaying peptide antigens in association with MHC molecules on their surface. A cellular immune response also leads to the production of cytokines, chemokines, and other such molecules produced by activated T-cells and/or other white blood cells including those derived from CD4+ and CD8+ T-cells. 
     In some embodiments, the antigen-specific immune response is characterized by measuring an anti- Salmonella  antigen antibody titer produced in a subject administered a  Salmonella  RNA (e.g., mRNA) vaccine as provided herein. An antibody titer is a measurement of the amount of antibodies within a subject, for example, antibodies that are specific to a particular antigen (e.g., an anti- Salmonella  antigen) or epitope of an antigen. Antibody titer is typically expressed as the inverse of the greatest dilution that provides a positive result. Enzyme-linked immunosorbent assay (ELISA) is a common assay for determining antibody titers, for example. 
     In some embodiments, an antibody titer is used to assess whether a subject has had an infection or to determine whether immunizations are required. In some embodiments, an antibody titer is used to determine the strength of an autoimmune response, to determine whether a booster immunization is needed, to determine whether a previous vaccine was effective, and to identify any recent or prior infections. In accordance with the present disclosure, an antibody titer may be used to determine the strength of an immune response induced in a subject by the  Salmonella  RNA (e.g., mRNA) vaccine. 
     In some embodiments, an anti- Salmonella  antigen antibody titer produced in a subject is increased by at least 1 log relative to a control. For example, anti- Salmonella  antigen antibody titer produced in a subject may be increased by at least 1.5, at least 2, at least 2.5, or at least 3 log relative to a control. In some embodiments, the anti- Salmonella  antigen antibody titer produced in the subject is increased by 1, 1.5, 2, 2.5 or 3 log relative to a control. In some embodiments, the anti- Salmonella  antigen antibody titer produced in the subject is increased by 1-3 log relative to a control. For example, the anti- Salmonella  antigen antibody titer produced in a subject may be increased by 1-1.5, 1-2, 1-2.5, 1-3, 1.5-2, 1.5-2.5, 1.5-3, 2-2.5, 2-3, or 2.5-3 log relative to a control. 
     In some embodiments, the anti- Salmonella  antigen antibody titer produced in a subject is increased at least 2 times relative to a control. For example, the anti- Salmonella  antigen antibody titer produced in a subject may be increased at least 3 times, at least 4 times, at least 5 times, at least 6 times, at least 7 times, at least 8 times, at least 9 times, or at least 10 times relative to a control. In some embodiments, the anti- Salmonella  antigen antibody titer produced in the subject is increased 2, 3, 4, 5, 6, 7, 8, 9, or 10 times relative to a control. In some embodiments, the anti- Salmonella  antigen antibody titer produced in a subject is increased 2-10 times relative to a control. For example, the anti- Salmonella  antigen antibody titer produced in a subject may be increased 2-10, 2-9, 2-8, 2-7, 2-6, 2-5, 2-4, 2-3, 3-10, 3-9, 3-8, 3-7, 3-6, 3-5, 3-4, 4-10, 4-9, 4-8, 4-7, 4-6, 4-5, 5-10, 5-9, 5-8, 5-7, 5-6, 6-10, 6-9, 6-8, 6-7, 7-10, 7-9, 7-8, 8-10, 8-9, or 9-10 times relative to a control. 
     A control, in some embodiments, is the anti- Salmonella  antigen antibody titer produced in a subject who has not been administered a  Salmonella  RNA (e.g., mRNA) vaccine. In some embodiments, a control is an anti- Salmonella  antigen antibody titer produced in a subject administered a recombinant or purified  Salmonella  protein vaccine. Recombinant protein vaccines typically include protein antigens that either have been produced in a heterologous expression system (e.g., bacteria or yeast) or purified from large amounts of the pathogenic organism. 
     In some embodiments, the ability of a  Salmonella  vaccine to be effective is measured in a murine model. For example, the  Salmonella  vaccines may be administered to a murine model and the murine model assayed for induction of neutralizing antibody titers. Pathogen challenge studies may also be used to assess the efficacy of a vaccine of the present disclosure. For example, the  Salmonella  vaccines may be administered to a murine model, the murine model challenged with  Salmonella  pathogen, and the murine model assayed for survival and/or immune response (e.g., neutralizing antibody response, T cell response (e.g., cytokine response)). 
     In some embodiments, an effective amount of a  Salmonella  RNA (e.g., mRNA) vaccine is a dose that is reduced compared to the standard of care dose of a recombinant  Salmonella  protein vaccine. A “standard of care,” as provided herein, refers to a medical or psychological treatment guideline and can be general or specific. “Standard of care” specifies appropriate treatment based on scientific evidence and collaboration between medical professionals involved in the treatment of a given condition. It is the diagnostic and treatment process that a physician/clinician should follow for a certain type of patient, illness or clinical circumstance. A “standard of care dose,” as provided herein, refers to the dose of a recombinant or purified  Salmonella  protein vaccine, or a live attenuated or inactivated  Salmonella  vaccine, or a  Salmonella  VLP vaccine, that a physician/clinician or other medical professional would administer to a subject to treat or prevent  Salmonella , or a  Salmonella -related condition, while following the standard of care guideline for treating or preventing  Salmonella , or a  Salmonella -related condition. 
     In some embodiments, the anti- Salmonella  antigen antibody titer produced in a subject administered an effective amount of a  Salmonella  RNA vaccine is equivalent to an anti- Salmonella  antigen antibody titer produced in a control subject administered a standard of care dose of a recombinant or purified  Salmonella  protein vaccine, or a live attenuated or inactivated  Salmonella  vaccine, or a  Salmonella  VLP vaccine. 
     In some embodiments, an effective amount of a  Salmonella  RNA (e.g., mRNA) vaccine is a dose equivalent to an at least 2-fold reduction in a standard of care dose of a recombinant or purified  Salmonella  protein vaccine. For example, an effective amount of a  Salmonella  RNA vaccine may be a dose equivalent to an at least 3-fold, at least 4-fold, at least 5-fold, at least 6-fold, at least 7-fold, at least 8-fold, at least 9-fold, or at least 10-fold reduction in a standard of care dose of a recombinant or purified  Salmonella  protein vaccine. In some embodiments, an effective amount of a  Salmonella  RNA vaccine is a dose equivalent to an at least at least 100-fold, at least 500-fold, or at least 1000-fold reduction in a standard of care dose of a recombinant or purified  Salmonella  protein vaccine. In some embodiments, an effective amount of a  Salmonella  RNA vaccine is a dose equivalent to a 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9-, 10-, 20-, 50-, 100-, 250-, 500-, or 1000-fold reduction in a standard of care dose of a recombinant or purified  Salmonella  protein vaccine. In some embodiments, the anti- Salmonella  antigen antibody titer produced in a subject administered an effective amount of a  Salmonella  RNA vaccine is equivalent to an anti- Salmonella  antigen antibody titer produced in a control subject administered the standard of care dose of a recombinant or protein  Salmonella  protein vaccine, or a live attenuated or inactivated  Salmonella  vaccine, or a  Salmonella  VLP vaccine. In some embodiments, an effective amount of a  Salmonella  RNA (e.g., mRNA) vaccine is a dose equivalent to a 2-fold to 1000-fold (e.g., 2-fold to 100-fold, 10-fold to 1000-fold) reduction in the standard of care dose of a recombinant or purified  Salmonella  protein vaccine, wherein the anti- Salmonella  antigen antibody titer produced in the subject is equivalent to an anti- Salmonella  antigen antibody titer produced in a control subject administered the standard of care dose of a recombinant or purified  Salmonella  protein vaccine, or a live attenuated or inactivated  Salmonella  vaccine, or a  Salmonella  VLP vaccine. 
     In some embodiments, the effective amount of a  Salmonella  RNA (e.g., mRNA) vaccine is a dose equivalent to a 2 to 1000-, 2 to 900-, 2 to 800-, 2 to 700-, 2 to 600-, 2 to 500-, 2 to 400-, 2 to 300-, 2 to 200-, 2 to 100-, 2 to 90-, 2 to 80-, 2 to 70-, 2 to 60-, 2 to 50-, 2 to 40-, 2 to 30-, 2 to 20-, 2 to 10-, 2 to 9-, 2 to 8-, 2 to 7-, 2 to 6-, 2 to 5-, 2 to 4-, 2 to 3-, 3 to 1000-, 3 to 900-, 3 to 800-, 3 to 700-, 3 to 600-, 3 to 500-, 3 to 400-, 3 to 3 to 00-, 3 to 200-, 3 to 100-, 3 to 90-, 3 to 80-, 3 to 70-, 3 to 60-, 3 to 50-, 3 to 40-, 3 to 30-, 3 to 20-, 3 to 10-, 3 to 9-, 3 to 8-, 3 to 7-, 3 to 6-, 3 to 5-, 3 to 4-, 4 to 1000-, 4 to 900-, 4 to 800-, 4 to 700-, 4 to 600-, 4 to 500-, 4 to 400-, 4 to 4 to 00-, 4 to 200-, 4 to 100-, 4 to 90-, 4 to 80-, 4 to 70-, 4 to 60-, 4 to 50-, 4 to 40-, 4 to 30-, 4 to 20-, 4 to 10-, 4 to 9-, 4 to 8-, 4 to 7-, 4 to 6-, 4 to 5-, 4 to 4-, 5 to 1000-, 5 to 900-, 5 to 800-, 5 to 700-, 5 to 600-, 5 to 500-, 5 to 400-, 5 to 300-, 5 to 200-, 5 to 100-, 5 to 90-, 5 to 80-, 5 to 70-, 5 to 60-, 5 to 50-, 5 to 40-, 5 to 30-, 5 to 20-, 5 to 10-, 5 to 9-, 5 to 8-, 5 to 7-, 5 to 6-, 6 to 1000-, 6 to 900-, 6 to 800-, 6 to 700-, 6 to 600-, 6 to 500-, 6 to 400-, 6 to 300-, 6 to 200-, 6 to 100-, 6 to 90-, 6 to 80-, 6 to 70-, 6 to 60-, 6 to 50-, 6 to 40-, 6 to 30-, 6 to 20-, 6 to 10-, 6 to 9-, 6 to 8-, 6 to 7-, 7 to 1000-, 7 to 900-, 7 to 800-, 7 to 700-, 7 to 600-, 7 to 500-, 7 to 400-, 7 to 300-, 7 to 200-, 7 to 100-, 7 to 90-, 7 to 80-, 7 to 70-, 7 to 60-, 7 to 50-, 7 to 40-, 7 to 30-, 7 to 20-, 7 to 10-, 7 to 9-, 7 to 8-, 8 to 1000-, 8 to 900-, 8 to 800-, 8 to 700-, 8 to 600-, 8 to 500-, 8 to 400-, 8 to 300-, 8 to 200-, 8 to 100-, 8 to 90-, 8 to 80-, 8 to 70-, 8 to 60-, 8 to 50-, 8 to 40-, 8 to 30-, 8 to 20-, 8 to 10-, 8 to 9-, 9 to 1000-, 9 to 900-, 9 to 800-, 9 to 700-, 9 to 600-, 9 to 500-, 9 to 400-, 9 to 300-, 9 to 200-, 9 to 100-, 9 to 90-, 9 to 80-, 9 to 70-, 9 to 60-, 9 to 50-, 9 to 40-, 9 to 30-, 9 to 20-, 9 to 10-, 10 to 1000-, 10 to 900-, 10 to 800-, 10 to 700-, 10 to 600-, 10 to 500-, 10 to 400-, 10 to 300-, 10 to 200-, 10 to 100-, 10 to 90-, 10 to 80-, 10 to 70-, 10 to 60-, 10 to 50-, 10 to 40-, 10 to 30-, 10 to 20-, 20 to 1000-, 20 to 900-, 20 to 800-, 20 to 700-, 20 to 600-, 20 to 500-, 20 to 400-, 20 to 300-, 20 to 200-, 20 to 100-, 20 to 90-, 20 to 80-, 20 to 70-, 20 to 60-, 20 to 50-, 20 to 40-, 20 to 30-, 30 to 1000-, 30 to 900-, 30 to 800-, 30 to 700-, 30 to 600-, 30 to 500-, 30 to 400-, 30 to 300-, 30 to 200-, 30 to 100-, 30 to 90-, 30 to 80-, 30 to 70-, 30 to 60-, 30 to 50-, 30 to 40-, 40 to 1000-, 40 to 900-, 40 to 800-, 40 to 700-, 40 to 600-, 40 to 500-, 40 to 400-, 40 to 300-, 40 to 200-, 40 to 100-, 40 to 90-, 40 to 80-, 40 to 70-, 40 to 60-, 40 to 50-, 50 to 1000-, 50 to 900-, 50 to 800-, 50 to 700-, 50 to 600-, 50 to 500-, 50 to 400-, 50 to 300-, 50 to 200-, 50 to 100-, 50 to 90-, 50 to 80-, 50 to 70-, 50 to 60-, 60 to 1000-, 60 to 900-, 60 to 800-, 60 to 700-, 60 to 600-, 60 to 500-, 60 to 400-, 60 to 300-, 60 to 200-, 60 to 100-, 60 to 90-, 60 to 80-, 60 to 70-, 70 to 1000-, 70 to 900-, 70 to 800-, 70 to 700-, 70 to 600-, 70 to 500-, 70 to 400-, 70 to 300-, 70 to 200-, 70 to 100-, 70 to 90-, 70 to 80-, 80 to 1000-, 80 to 900-, 80 to 800-, 80 to 700-, 80 to 600-, 80 to 500-, 80 to 400-, 80 to 300-, 80 to 200-, 80 to 100-, 80 to 90-, 90 to 1000-, 90 to 900-, 90 to 800-, 90 to 700-, 90 to 600-, 90 to 500-, 90 to 400-, 90 to 300-, 90 to 200-, 90 to 100-, 100 to 1000-, 100 to 900-, 100 to 800-, 100 to 700-, 100 to 600-, 100 to 500-, 100 to 400-, 100 to 300-, 100 to 200-, 200 to 1000-, 200 to 900-, 200 to 800-, 200 to 700-, 200 to 600-, 200 to 500-, 200 to 400-, 200 to 300-, 300 to 1000-, 300 to 900-, 300 to 800-, 300 to 700-, 300 to 600-, 300 to 500-, 300 to 400-, 400 to 1000-, 400 to 900-, 400 to 800-, 400 to 700-, 400 to 600-, 400 to 500-, 500 to 1000-, 500 to 900-, 500 to 800-, 500 to 700-, 500 to 600-, 600 to 1000-, 600 to 900-, 600 to 800-, 600 to 700-, 700 to 1000-, 700 to 900-, 700 to 800-, 800 to 1000-, 800 to 900-, or 900 to 1000-fold reduction in the standard of care dose of a recombinant  Salmonella  protein vaccine. In some embodiments, such as the foregoing, the anti- Salmonella  antigen antibody titer produced in the subject is equivalent to an anti- Salmonella  antigen antibody titer produced in a control subject administered the standard of care dose of a recombinant or purified  Salmonella  protein vaccine, or a live attenuated or inactivated  Salmonella  vaccine, or a  Salmonella  VLP vaccine. In some embodiments, the effective amount is a dose equivalent to (or equivalent to an at least) 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9-, 10-, 20-, 30-, 40-, 50-, 60-, 70-, 80-, 90-, 100-, 110-, 120-, 130-, 140-, 150-, 160-, 170-, 1280-, 190-, 200-, 210-, 220-, 230-, 240-, 250-, 260-, 270-, 280-, 290-, 300-, 310-, 320-, 330-, 340-, 350-, 360-, 370-, 380-, 390-, 400-, 410-, 420-, 430-, 440-, 450-, 4360-, 470-, 480-, 490-, 500-, 510-, 520-, 530-, 540-, 550-, 560-, 5760-, 580-, 590-, 600-, 610-, 620-, 630-, 640-, 650-, 660-, 670-, 680-, 690-, 700-, 710-, 720-, 730-, 740-, 750-, 760-, 770-, 780-, 790-, 800-, 810-, 820-, 830-, 840-, 850-, 860-, 870-, 880-, 890-, 900-, 910-, 920-, 930-, 940-, 950-, 960-, 970-, 980-, 990-, or 1000-fold reduction in the standard of care dose of a recombinant  Salmonella  protein vaccine. In some embodiments, such as the foregoing, an anti- Salmonella  antigen antibody titer produced in the subject is equivalent to an anti- Salmonella  antigen antibody titer produced in a control subject administered the standard of care dose of a recombinant or purified  Salmonella  protein vaccine, or a live attenuated or inactivated  Salmonella  vaccine, or a  Salmonella  VLP vaccine. 
     In some embodiments, the effective amount of a  Salmonella  RNA (e.g., mRNA) vaccine is a total dose of 50-1000 μg. In some embodiments, the effective amount of a  Salmonella  RNA (e.g., mRNA) vaccine is a total dose of 50-1000, 50-900, 50-800, 50-700, 50-600, 50-500, 50-400, 50-300, 50-200, 50-100, 50-90, 50-80, 50-70, 50-60, 60-1000, 60-900, 60-800, 60-700, 60-600, 60-500, 60-400, 60-300, 60-200, 60-100, 60-90, 60-80, 60-70, 70-1000, 70-900, 70-800, 70-700, 70-600, 70-500, 70-400, 70-300, 70-200, 70-100, 70-90, 70-80, 80-1000, 80-900, 80-800, 80-700, 80-600, 80-500, 80-400, 80-300, 80-200, 80-100, 80-90, 90-1000, 90-900, 90-800, 90-700, 90-600, 90-500, 90-400, 90-300, 90-200, 90-100, 100-1000, 100-900, 100-800, 100-700, 100-600, 100-500, 100-400, 100-300, 100-200, 200-1000, 200-900, 200-800, 200-700, 200-600, 200-500, 200-400, 200-300, 300-1000, 300-900, 300-800, 300-700, 300-600, 300-500, 300-400, 400-1000, 400-900, 400-800, 400-700, 400-600, 400-500, 500-1000, 500-900, 500-800, 500-700, 500-600, 600-1000, 600-900, 600-900, 600-700, 700-1000, 700-900, 700-800, 800-1000, 800-900, or 900-1000 μg. In some embodiments, the effective amount of a  Salmonella  RNA (e.g., mRNA) vaccine is a total dose of 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950 or 1000 μg. In some embodiments, the effective amount is a dose of 25-500 μg administered to the subject a total of two times. In some embodiments, the effective amount of a  Salmonella  RNA (e.g., mRNA) vaccine is a dose of 25-500, 25-400, 25-300, 25-200, 25-100, 25-50, 50-500, 50-400, 50-300, 50-200, 50-100, 100-500, 100-400, 100-300, 100-200, 150-500, 150-400, 150-300, 150-200, 200-500, 200-400, 200-300, 250-500, 250-400, 250-300, 300-500, 300-400, 350-500, 350-400, 400-500 or 450-500 μg administered to the subject a total of two times. In some embodiments, the effective amount of a  Salmonella  RNA (e.g., mRNA) vaccine is a total dose of 25, 50, 100, 150, 200, 250, 300, 350, 400, 450, or 500 μg administered to the subject a total of two times. 
     Vaccine efficacy may be assessed using standard analyses (see, e.g., Weinberg et al., J Infect Dis. 2010 Jun. 1; 201(11):1607-10). For example, vaccine efficacy may be measured by double-blind, randomized, clinical controlled trials. Vaccine efficacy may be expressed as a proportionate reduction in disease attack rate (AR) between the unvaccinated (ARU) and vaccinated (ARV) study cohorts and can be calculated from the relative risk (RR) of disease among the vaccinated group with use of the following formulas: 
       Efficacy=(ARU−ARV)/ARU×100; and
 
       Efficacy=(1−RR)×100.
 
     Likewise, vaccine effectiveness may be assessed using standard analyses (see, e.g., Weinberg et al., J Infect Dis. 2010 Jun. 1; 201(11):1607-10). Vaccine effectiveness is an assessment of how a vaccine (which may have already proven to have high vaccine efficacy) reduces disease in a population. This measure can assess the net balance of benefits and adverse effects of a vaccination program, not just the vaccine itself, under natural field conditions rather than in a controlled clinical trial. Vaccine effectiveness is proportional to vaccine efficacy (potency) but is also affected by how well target groups in the population are immunized, as well as by other non-vaccine-related factors that influence the ‘real-world’ outcomes of hospitalizations, ambulatory visits, or costs. For example, a retrospective case control analysis may be used, in which the rates of vaccination among a set of infected cases and appropriate controls are compared. Vaccine effectiveness may be expressed as a rate difference, with use of the odds ratio (OR) for developing infection despite vaccination: 
       Effectiveness=(1−OR)×100.
 
     In some embodiments, efficacy of the  Salmonella  vaccine is at least 60% relative to unvaccinated control subjects. For example, efficacy of the  Salmonella  vaccine may be at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 95%, at least 98%, or 100% relative to unvaccinated control subjects. 
     Sterilizing Immunity. 
     Sterilizing immunity refers to a unique immune status that prevents effective pathogen infection into the host. In some embodiments, the effective amount of a  Salmonella  vaccine of the present disclosure is sufficient to provide sterilizing immunity in the subject for at least 1 year. For example, the effective amount of a  Salmonella  vaccine of the present disclosure is sufficient to provide sterilizing immunity in the subject for at least 2 years, at least 3 years, at least 4 years, or at least 5 years. In some embodiments, the effective amount of a  Salmonella  vaccine of the present disclosure is sufficient to provide sterilizing immunity in the subject at an at least 5-fold lower dose relative to control. For example, the effective amount may be sufficient to provide sterilizing immunity in the subject at an at least 10-fold lower, 15-fold, or 20-fold lower dose relative to a control. 
     Detectable Antigen. 
     In some embodiments, the effective amount of a  Salmonella  vaccine of the present disclosure is sufficient to produce detectable levels of  Salmonella  antigen as measured in serum of the subject at 1-72 hours post administration. 
     Titer. 
     An antibody titer is a measurement of the amount of antibodies within a subject, for example, antibodies that are specific to a particular antigen (e.g., an anti- Salmonella  antigen). Antibody titer is typically expressed as the inverse of the greatest dilution that provides a positive result. Enzyme-linked immunosorbent assay (ELISA) is a common assay for determining antibody titers, for example. 
     In some embodiments, the effective amount of a  Salmonella  vaccine of the present disclosure is sufficient to produce a 1,000-10,000 neutralizing antibody titer produced by neutralizing antibody against the  Salmonella  antigen as measured in serum of the subject at 1-72 hours post administration. In some embodiments, the effective amount is sufficient to produce a 1,000-5,000 neutralizing antibody titer produced by neutralizing antibody against the  Salmonella  antigen as measured in serum of the subject at 1-72 hours post administration. In some embodiments, the effective amount is sufficient to produce a 5,000-10,000 neutralizing antibody titer produced by neutralizing antibody against the  Salmonella  antigen as measured in serum of the subject at 1-72 hours post administration. 
     In some embodiments, the neutralizing antibody titer is at least 100 neutralizing units per milliliter (U/ml). For example, the neutralizing antibody titer may be at least 200, 300, 400, 500, 600, 700, 800, 900 or 1000 U/ml. In some embodiments, the neutralizing antibody titer is at least 10,000 U/ml. 
     In some embodiments, an anti- Salmonella  antigen antibody titer produced in the subject is increased by at least 1 log relative to a control. For example, an anti- Salmonella  antigen antibody titer produced in the subject may be increased by at least 2, 3, 4, 5, 6, 7, 8, 9 or 10 log relative to a control. 
     In some embodiments, an anti- Salmonella  antigen antibody titer produced in the subject is increased at least 2 times relative to a control. For example, an anti- Salmonella  antigen antibody titer produced in the subject is increased by at least 3, 4, 5, 6, 7, 8, 9 or 10 times relative to a control. 
     In some embodiments, a geometric mean, which is the nth root of the product of n numbers, is generally used to describe proportional growth. Geometric mean, in some embodiments, is used to characterize antibody titer produced in a subject. 
     A control may be, for example, an unvaccinated subject, or a subject administered a live attenuated  Salmonella  vaccine, an inactivated  Salmonella  vaccine, or a protein subunit  Salmonella  vaccine. 
     Neutralization Assays. 
     In some embodiments, the ability of antibodies induced by an antigen of the disclosure to neutralize  Salmonella  pathogens is measured. For example, in one embodiment, a serum bactericidal antibody (SBA) assay that measures complement mediated killing via antibody can be used. This assay uses active complement, either intrinsic from the serum being tested or the addition of exogenous complement, either from a human or from another species such as rabbit. Antibodies that are capable of opsonizing the bacteria facilitate binding of complement and killing of the bacteria. Alternatively, the ability of an antibody to opsonize bacteria and facilitate uptake by phagocytic cells may also be measured. It will be understood that either of these assays, in addition to measuring neutralization/bactericidal ability of an antibody, may be used to measure functional antibody titers against bacterial pathogens. 
     EXAMPLES 
     Example 1: Antigen Expression Studies 
     These studies were designed to test the in vitro expression of  Salmonella  antigens from various mRNA vaccines of the present disclosure. mRNA vaccines encoding SseB, Mit14, OmpL, OmpC, OmpD, OmpF, IroN, CirA, FepA, T0937, FliC, PiIL, PltB, PltA, CdtB, SlyB, Sty1086, or STY0796 antigens linked to C-terminal His tags were tested. The mRNA constructs were transfected into HEK293F cells. Twenty hours post transfection, the cell culture supernatant (normal or concentrated) or HEK293F cell lysates were collected, and expression of the antigens present in the supernatant or lysate was analyzed by Western blot. Mouse anti-His antibodies were used as the primary antibody, and anti-mouse A1647 antibodies were used as the secondary antibody. GFP and untransfected cells were used as controls. The results of the Western blot are provided below in Tables 1-8. Antigen expression in the supernatant is indicative of antigen secretion from the cells. NGM=non-glycosylation mutant; nIgK=N-terminal humanized IgK signal sequence; nFLRT2=N-terminal humanized FLRT2 signal sequence; cHis=C-terminal His tag (6×). 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Protein Expression of OmpC, SseB, and FliC 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 WB 
                   
               
               
                   
                   
                   
                 QC 
                 WB 
                 Observed 
                 WB 
               
               
                   
                   
                 Expected 
                 Measured 
                 Observed 
                 MW 
                 Observed 
               
               
                   
                   
                 Molecular 
                 Molecular 
                 MW 
                 Concentrated 
                 MW 
               
               
                 SEQ ID 
                   
                 Weight 
                 Weight 
                 Lysate 
                 supernatant 
                 Supernatant 
               
               
                 NO: 
                 mRNA Name 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 20 
                 St_OmpC_NGM_nIgk_cHis 
                 42.118 
                 43.098 
                 42-49* 
                 — 
                 — 
               
               
                 24 
                 St_SseB_cHis 
                 29.71 
                 32.723 
                 28-38** 
                 28-38* 
                 — 
               
               
                 28 
                 St_SseB_nIgK_cHis 
                 31.833 
                 34.804 
                 28-38*** 
                 28-38*** 
                 28-38* 
               
               
                 32 
                 St_FliC_cHis 
                 54.093 
                 58.599 
                 49-62** 
                 49-62* 
                 — 
               
               
                 36 
                 St_FliC_nIgK_cHis 
                 56.216 
                 60.036 
                 — 
                 62** 
                 — 
               
               
                 — 
                 GFP 
                 — 
                 — 
                 — 
                 — 
                 — 
               
               
                   
               
               
                 Relative expression level: *low, **medium, ***high 
               
            
           
         
       
     
     Table 1 shows results from a Western blot analysis of protein collected from HEK293F cells transfected with: 
     mRNA encoding an OmpC non-glycosylation mutant (NGM) antigen from  Salmonella typhi  (St) having a humanized IgK signal sequence and a 6×His tag (St_OmpC_NGM_nIgk_cHis); 
     mRNA encoding SseB antigen from  S. typhi  having a 6×His tag (St_SseB cHis); 
     mRNA encoding a SseB antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_SseB_nIgk_cHis); 
     mRNA encoding a FliC antigen from  S. typhi  having a 6×His tag (St_FliC_cHis); 
     mRNA encoding a FliC antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_OmpC_NGM_nIgk_cHis); or mRNA encoding GFP as a control. 
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Protein Expression of OmpC and Mig14 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 WB 
                   
               
               
                   
                   
                   
                 QC 
                 WB 
                 Observed 
                 WB 
               
               
                   
                   
                 Expected 
                 Measured 
                 Observed 
                 MW 
                 Observed 
               
               
                 SEQ 
                   
                 Molecular 
                 Molecular 
                 MW 
                 Concentrated 
                 MW 
               
               
                 ID 
                   
                 Weight 
                 Weight 
                 Lysate 
                 supernatant 
                 Supernatant 
               
               
                 NO: 
                 mRNA Name 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 20 
                 St_OmpC_NGM_nIgk_cHis 
                 42.118 
                 43.098 
                 42 &amp; 44* 
                 — 
                 — 
               
               
                 2 
                 St_OmpC_nIgK_cHis 
                 42.256 
                 42.593 
                 62* 
                 — 
                 — 
               
               
                 58 
                 St_Mig14_cHis 
                 36.009 
                 33.634 
                 — 
                 — 
                 — 
               
               
                 62 
                 St_Mig14_nIgK_cHis 
                 38.098 
                 34.873 
                 38*** 
                 — 
                 — 
               
               
                 66 
                 St_Mig14_NGM_cHis 
                 35.977 
                 33.386 
                 — 
                 — 
                 — 
               
               
                 70 
                 St_Mig14_NGM_nIgK_cHis 
                 38.066 
                 34.109 
                 38*** 
                 — 
                 — 
               
               
                 — 
                 GFP 
                 — 
                 — 
                 — 
                 — 
                 — 
               
               
                   
               
               
                 Relative expression level: *low, **medium, ***high 
               
            
           
         
       
     
     Table 2 shows results from a Western blot analysis of protein collected from HEK293F cells transfected with: 
     mRNA encoding an OmpC NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_OmpC_NGM_nIgk_cHis); 
     mRNA encoding OmpC antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_Omp_nIgK_cHis); 
     mRNA encoding a Mig14 antigen from  S. typhi  having a 6×His tag (St_Mig14_cHis); 
     mRNA encoding a Mig14 antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_Mig14_nIgK_cHis); 
     mRNA encoding a Mig14_NGM antigen from  S. typhi  having a 6×His tag (St_Mig14_NGM_cHis); 
     mRNA encoding a Mig14_NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_Mig14_NGM_cHis); or mRNA encoding GFP as a control. 
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Protein Expression of OmpF, OmpL, and CirA 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 WB 
                   
               
               
                   
                   
                   
                 QC 
                 WB 
                 Observed 
                 WB 
               
               
                   
                   
                 Expected 
                 Measured 
                 Observed 
                 MW 
                 Observed 
               
               
                 SEQ 
                   
                 Molecular 
                 Molecular 
                 MW 
                 Concentrated 
                 MW 
               
               
                 ID 
                   
                 Weight 
                 Weight 
                 Lysate 
                 supernatant 
                 Supernatant 
               
               
                 NO: 
                 mRNA Name 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 8 
                 St_OmpF_nIgK_cHis variant 
                 40.963 
                 41.724 
                 — 
                 — 
                 — 
               
               
                 106 
                 St_OmpL_nIgK_cHis 
                 28.106 
                 27.381 
                 38** 
                 — 
                 — 
               
               
                 110 
                 St_OmpL_NGM_nIgK_cHis 
                 28.03 
                 27.599 
                 28* 
                 — 
                 — 
               
               
                 80 
                 St_CirA_nFLRT2_cHis 
                 75.618 
                 77.01 
                 — 
                 — 
                 — 
               
               
                 84 
                 St_CirA_NGM_nFLRT2_cHis 
                 75.498 
                 79.063 
                 70-98** 
                 70-98** 
                 — 
               
               
                 — 
                 GFP 
                 — 
                 — 
                 — 
                 — 
                 — 
               
               
                   
               
               
                 Relative expression level: *low, **medium, ***high 
               
            
           
         
       
     
     Table 3 shows results from a Western blot analysis of protein collected from HEK293F cells transfected with: 
     mRNA encoding an OmpF antigen variant from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_OmpF_nIgk_cHis); 
     mRNA encoding an OmpL antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_OmpL_nIgk_cHis); 
     mRNA encoding an OmpL NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_OmpL_NGM_nIgk_cHis); 
     mRNA encoding a CirA antigen from  S. typhi  having a humanized FLRT2 signal sequence and a 6×His tag (St_CirA_nFLRT2_cHis); 
     mRNA encoding a CirA NGM antigen from  S. typhi  having a humanized FLRT2 signal sequence and a 6×His tag (St_CirA_NGM_nFLRT2_cHis); or mRNA encoding GFP as a control. 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Protein Expression of Typhoid Toxin Subunits 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 Observed 
               
               
                   
                   
                 Expected 
                 QC 
                 Observed 
                 MW 
               
               
                   
                   
                 MW 
                 Measured 
                 MW Lysate 
                 Sup/cSup 
               
               
                 SEQ ID NO: 
                 mRNA Construct 
                 (kD) 
                 MW (kD) 
                 (kD) 
                 (kD) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 102 
                 St_CdtB_NGM_nIgK_cHis 
                 30.112 
                 32.686 
                 30** 
                 30* cS 
               
               
                 158 
                 St_CdtB_nIgK_cHis 
                 30.128 
                 31.767 
                 30** 
                 30* cS 
               
               
                 118 
                 St_PltA_NGM_nIgK_cHis 
                 28.142 
                 27.909 
                 35*  
                 ~ 
               
               
                 114 
                 St_PltA_nIgK_cHis 
                 28.172 
                 28.954 
                 38*  
                 ~ 
               
               
                 126 
                 St_PltB_NGM_nIgK_cHis 
                 15.615 
                 15.507 
                 14** 
                 ~ 
               
               
                 122 
                 St_PltB_nIgK_cHis 
                 16.631 
                 16.481 
                 14** 
                 ~ 
               
               
                   
               
               
                 Relative expression level: 
               
               
                 *low, 
               
               
                 **medium, 
               
               
                 ***high 
               
            
           
         
       
     
     Table 4 shows results from a Western blot analysis of protein collected from HEK293F cells transfected with: 
     mRNA encoding CdtB NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_CdtB_NGM_nIgK_cHis); 
     mRNA encoding CdtB antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_CdtB_nIgK_cHis); 
     mRNA encoding PltA NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_PltA_NGM_nIgK_cHis); 
     mRNA encoding PltA antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_PltA_nIgK_cHis); 
     mRNA encoding PtlB NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_PtlB_NGM_nIgK_cHis); or 
     mRNA encoding PtlB antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_PtlB_nIgK_cHis). 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Protein Expression of FepA, OmpF, and OmpD 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 WB 
                   
               
               
                   
                   
                   
                 QC 
                 WB 
                 Observed 
                 WB 
               
               
                   
                   
                 Expected 
                 Measured 
                 Observed 
                 MW 
                 Observed 
               
               
                   
                   
                 Molecular 
                 Molecular 
                 MW 
                 Concentrated 
                 MW 
               
               
                 SEQ ID 
                   
                 Weight 
                 Weight 
                 Lysate 
                 supernatant 
                 Supernatant 
               
               
                 NO: 
                 mRNA Name 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 90 
                 St_FepA_nIgK_cHis 
                 83.439 
                 90.33 
                 95-70** 
                 — 
                 — 
               
               
                 94 
                 St_FepA_NGM_nIgK_cHis 
                 83.227 
                 88.344 
                 — 
                 — 
                 — 
               
               
                 12 
                 St_OmpF_NGM_nIgK_cHis 
                 40.917 
                 41.793 
                 40* 
                 — 
                 — 
               
               
                   
                 variant 
               
               
                 16 
                 Stm_OmpD_nIgK_cHis 
                 40.707 
                 43.323 
                 — 
                 — 
                 — 
               
               
                   
                 variant 
               
               
                 — 
                 GFP 
                 — 
                 — 
                 — 
                 — 
                 — 
               
               
                   
               
               
                 Relative expression level: *low, **medium, ***high 
               
            
           
         
       
     
     Table 5 shows results from a Western blot analysis of protein collected from HEK293F cells transfected with: 
     mRNA encoding an FepA antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_FepA_nIgk_cHis); 
     mRNA encoding an FepA NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_FepA_NGM_nIgk_cHis); 
     mRNA encoding an OmpF NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_OmpF_NGM_nIgk_cHis); 
     mRNA encoding an OmpD antigen variant from  S. typhimurium  (Stm) having a humanized IgK signal sequence and a 6×His tag (Stm_OmpD_nIgk_cHis); or mRNA encoding GFP as a control. 
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Protein Expression of FliC variants 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 Expected 
                 QC measured 
                   
               
               
                 SEQ 
                   
                 Molecular 
                 Molecular 
                 Observed 
               
               
                 ID 
                   
                 Weight 
                 Weight 
                 MW cSup 
               
               
                 NO: 
                 mRNA name 
                 (kD) 
                 (kD) 
                 (kD) 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 44 
                 SpA_FliC_nIgK_cHis 
                 54.84 
                 57.203 
                 ~62 
               
               
                 48 
                 Stm_FliC_cHis 
                 52.434 
                 56.325 
                 ~51 
               
               
                 52 
                 Stm_FliC_nIgK_cHis 
                 54.5 
                 54.962 
                 ~62 
               
               
                 — 
                 GFP 
                 26.941 
                 27.313 
                 — 
               
               
                   
               
               
                 Relative expression level: 
               
               
                 *low, 
               
               
                 **medium, 
               
               
                 ***high 
               
            
           
         
       
     
     Table 6 shows results from a Western blot analysis of protein collected from HEK293F cells transfected with: 
     mRNA encoding an FliC antigen from  S. paratphi  (SpA) having a humanized IgK signal sequence and a 6×His tag (SpA_FliC_nIgk_cHis); 
     mRNA encoding an FliC antigen from  S. typhimurium  (Stm) having a 6×His tag (Stm_FliC_cHis); 
     mRNA encoding an FliC antigen from  S. typhimurium  (Stm) having a humanized IgK signal sequence and a 6×His tag (Stm_FliC_cHis); or 
     mRNA encoding GFP as a control. 
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 Protein Expression of IroN and ViMimotope 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 WB 
                   
               
               
                   
                   
                   
                 QC 
                 WB 
                 Observed 
                 WB 
               
               
                   
                   
                 Expected 
                 Measured 
                 Observed 
                 MW 
                 Observed 
               
               
                   
                   
                 Molecular 
                 Molecular 
                 MW 
                 Concentrated 
                 MW 
               
               
                 SEQ ID 
                   
                 Weight 
                 Weight 
                 Lysate 
                 supernatant 
                 Supernatant 
               
               
                 NO: 
                 mRNA Name 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 72 
                 St_IroN_nFLRT2_cHis 
                 81.32 
                 90.932 
                 75-98** 
                 — 
                 — 
               
               
                 88 
                 St_ViMimo_Lumazine_cHis 
                 24.206 
                 23.213 
                 — 
                 — 
                 — 
               
               
                 — 
                 GFP 
                 — 
                 — 
                 — 
                 — 
                 — 
               
               
                   
               
               
                 Relative expression level: *low, ** medium, ***high 
               
            
           
         
       
     
     Table 7 shows results from a Western blot analysis of protein collected from HEK293F cells transfected with: 
     mRNA encoding an IroN antigen from  S. typhi  having a humanized FLRT2 signal sequence and a 6×His tag (St_IroN_nFLRT2_cHis); 
     mRNA encoding a ViMimotope antigen (a polysaccharide that mimics the Vi  Salmonella  construct) fused to lumazine from  S. typhi  having a 6×His tag (St_ViMimo_Lumazine_cHis); or 
     mRNA encoding GFP as a control. 
     While the ViMimotope was not detected by Western blot, it was detected by liquid chromatography-mass spectrometry (LCMS) (data not shown). 
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 Protein Expression of T0937 and SlyB 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 WB 
                   
               
               
                   
                   
                   
                 QC 
                 WB 
                 Observed 
                 WB 
               
               
                   
                   
                 Expected 
                 Measured 
                 Observed 
                 MW 
                 Observed 
               
               
                 SEQ 
                   
                 Molecular 
                 Molecular 
                 MW 
                 Concentrated 
                 MW 
               
               
                 ID 
                   
                 Weight 
                 Weight 
                 Lysate 
                 supernatant 
                 Supernatant 
               
               
                 NO: 
                 mRNA Name 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
               
               
                   
               
               
                 133 
                 St_T0937_nIgk_NGM_cHis 
                 55 
                 56 
                 55** 
                 55** 
                 — 
               
               
                 135 
                 St_T0937_nIgk_nTrunc_NGM_cHis 
                 51 
                 47 
                 2 bands: 
                 — 
                 — 
               
               
                   
                   
                   
                   
                 47**, 
               
               
                   
                   
                   
                   
                 45** 
               
               
                 137 
                 St_slyB_nIgk_NGM_cHis 
                 16 
                 17 
                 15** 
                 17** 
                 17* 
               
               
                 — 
                 GFP 
                 — 
                 — 
                 — 
                 — 
                 — 
               
               
                   
               
               
                 Relative expression level: *low, **medium, ***high 
               
            
           
         
       
     
     Table 8 shows results from a Western blot analysis of protein collected from HEK293F cells transfected with: 
     mRNA encoding an T0937 NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_T0937_nIgK_NGM_cHis); 
     mRNA encoding an a truncated T0937 NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_T0937_nIgK_nTrunc_NGM_cHis); 
     mRNA encoding an SlyB NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_slyB_nIgK_NGM_cHis); or 
     mRNA encoding GFP as a control. 
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                 Protein Expression of STY0796 and STY1086 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 WB 
                   
               
               
                   
                   
                   
                 QC 
                 WB 
                 Observed 
                 WB 
               
               
                   
                   
                 Expected 
                 Measured 
                 Observed 
                 MW 
                 Observed 
               
               
                 SEQ 
                   
                 Molecular 
                 Molecular 
                 MW 
                 Concentrated 
                 MW 
               
               
                 ID 
                   
                 Weight 
                 Weight 
                 Lysate 
                 supernatant 
                 Supernatant 
               
               
                 NO: 
                 mRNA Name 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
                 (kD) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 144 
                 St_STY0796_nIgK_cHis 
                 29 
                 30 
                 — 
                 40** 
                 — 
               
               
                 146 
                 St_STY0796_NGM_nIgK_cHis 
                 28 
                 31 
                 — 
                 35** 
                 35** 
               
               
                 148 
                 St_STY1086_nIgK_cHis 
                 21 
                 22 
                 — 
                 2 bands: 
                 — 
               
               
                   
                   
                   
                   
                   
                 30**, 22** 
               
               
                 150 
                 St_STY1086_NGM_nIgK_cHis 
                 21 
                 22 
                 1788 
                 2 bands: 
                 — 
               
               
                   
                   
                   
                   
                   
                 22**, 17** 
               
               
                   
               
               
                 Relative expression level: *low, **medium, ***high 
               
            
           
         
       
     
     Table 9 shows results from a Western blot analysis of protein collected from HEK293F cells transfected with: 
     mRNA encoding a STY0796 antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_STY0796_nIgK_cHis); 
     mRNA encoding a STY0796 NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_STY0796_NGM_nIgK_cHis); 
     mRNA encoding a STY1086 antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_STY0796_nIgK_cHis); 
     mRNA encoding a STY1086 NGM antigen from  S. typhi  having a humanized IgK signal sequence and a 6×His tag (St_STY0796_NGM_nIgK_cHis); or mRNA encoding GFP as a control. 
     Example 2:  Salmonella  Immunogenicity Studies 
     The instant study was designed to test the immunogenicity of various  Salmonella  mRNA vaccines formulated in a lipid nanoparticle in vivo. Female BALB/c mice, 6-8 weeks of age (n=5 per group), were vaccinated intramuscularly with  Salmonella  mRNA vaccine encoding SseB (construct St_SseB_nIgK; SEQ ID NO:30 (mRNA ORF); SEQ ID NO:29 (protein ORF)) formulated in a lipid nanoparticle comprising Formula (I), Compound 1 lipids at a concentration of 0.2 mg/ml (10 μg SseB) or 0.04 mg/ml (2 μg SseB) on day 1. The mice were given a booster dose on day 29, and spleens were harvested on day 43. Blood samples were drawn three days before the first immunization, and then again on day 28, day 36, and day 43. Serum was isolated and stored at 20° C. On day 36, half of the mice were euthanized for spleen collection. Two groups were given PBS as a control (half were euthanized on day 36, and the other half were sacrificed on day 43). 
     As shown in  FIGS. 1A-1B , the  Salmonella  mRNA vaccine encoding SseB (construct St_SseB_nIgK; SEQ ID NO:30 (mRNA ORF); SEQ ID NO:29 (protein ORF)) was found to elicit SseB specific, IFN-γ, TNF-α and IL-2 secreting CD8 +  T cells. 
     The study was repeated using Mig14 with (construct St_Mig14_NGM_nIgK; SEQ ID NO:68 (mRNA ORF); SEQ ID NO:67 (protein ORF)) and without (construct St_Mig14_nIgK; SEQ ID NO:59 (mRNA ORF); SEQ ID NO:60 (protein ORF)) mutations at predicted N-linked glycosylation sites) mRNA. As shown in  FIGS. 2A-2B , both versions of Mig14 mRNA were able to elicit both CD4 +  and CD8 +  T cells. 
     EQUIVALENTS 
     All references, patents and patent applications disclosed herein are incorporated by reference with respect to the subject matter for which each is cited, which in some cases may encompass the entirety of the document. 
     The indefinite articles “a” and “an,” as used herein in the specification and in the claims, unless clearly indicated to the contrary, should be understood to mean “at least one.” It should also be understood that, unless clearly indicated to the contrary, in any methods claimed herein that include more than one step or act, the order of the steps or acts of the method is not necessarily limited to the order in which the steps or acts of the method are recited. 
     In the claims, as well as in the specification above, all transitional phrases such as “comprising,” “including,” “carrying,” “having,” “containing,” “involving,” “holding,” “composed of,” and the like are to be understood to be open-ended, i.e., to mean including but not limited to. Only the transitional phrases “consisting of” and “consisting essentially of” shall be closed or semi-closed transitional phrases, respectively, as set forth in the United States Patent Office Manual of Patent Examining Procedures, Section 2111.03. 
     The terms “about” and “substantially” preceding a numerical value mean±10% of the recited numerical value. 
     Where a range of values is provided, each value between the upper and lower ends of the range are specifically contemplated and described herein. 
     The entire contents of International Application Nos. PCT/US2015/02740, PCT/US2016/043348, PCT/US2016/043332, PCT/US2016/058327, PCT/US2016/058324, PCT/US2016/058314, PCT/US2016/058310, PCT/US2016/058321, PCT/US2016/058297, PCT/US2016/058319, and PCT/US2016/058314 are incorporated herein by reference. 
     SEQUENCE LISTING 
     It should be understood that any of the mRNA sequences described herein may include a 5′ UTR and/or a 3′ UTR. The UTR sequences may be selected from the following sequences, or other known UTR sequences may be used. It should also be understood that any of the mRNA constructs described herein may further comprise a polyA tail and/or cap (e.g., 7mG(5′)ppp(5′)NlmpNp). Further, while many of the mRNAs and encoded antigen sequences described herein include a signal peptide and/or a peptide tag (e.g., C-terminal His tag), it should be understood that the indicated signal peptide and/or peptide tag may be substituted for a different signal peptide and/or peptide tag, or the signal peptide and/or peptide tag may be omitted. 
     
       
         
           
               
            
               
                   
               
               
                 5′ UTR: 
               
               
                 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGAGCCACC 
               
               
                 (SEQ ID NO: 3) 
               
               
                 5′ UTR: 
               
               
                 GGGAAAUAAGAGAGAAAAGAAGAGUAAGAAGAAAUAUAAGACCCCGGCGCCGCCACC 
               
               
                 (SEQ ID NO: 140) 
               
               
                 3′ UTR: 
               
               
                 UGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCC 
               
               
                 UCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 
               
               
                 (SEQ ID NO: 4) 
               
               
                 3′ UTR: 
               
               
                 UGAUAAUAGGCUGGAGCCUCGGUGGCCUAGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCC 
               
               
                 UCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGC 
               
               
                 (SEQ ID NO: 129) 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 5 UTR 
                   
               
               
                   
                 mRNA 
                 Orf Sequence 
                 Orf Sequence 
                 Se- 
                 3 UTR 
               
               
                   
                 Name 
                 (Amino Acid) 
                 (Nucleotide) 
                 quence 
                 Sequence 
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 1 
                 2 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 161 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 2, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpC_ 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK_cHis 
                   PDTTG AEIYNKDGNK 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 IgK 
                 LDLFGKVDGLHYFSD 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                 underlined: 
                 DKGSDGDQTYMRIG 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                 
                   METPAQ 
                 
                 FKGETQVNDQLTGY 
                   AGGC GCCGAGAUCU 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                 
                   LLFLLLL 
                 
                 GQWEYQIQGNQTEG 
                 ACAACAAGGACGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                 
                   WLPDTT 
                 
                 SNDSWTRVAFAGLK 
                 AACAAGCUGGACCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   G  (SEQ ID 
                 FADAGSFDYGRNYG 
                 GUUCGGCAAGGUGG 
                 CCACC 
                 UGGGCC 
               
               
                   
                 NO: 153) 
                 VTYDVTSWTDVLPEF 
                 ACGGCCUGCACUAC 
                   
                 UCCCCC 
               
               
                   
                 
                   AUGGAA 
                 
                 GGDTYGADNFMQQR 
                 UUCAGCGACGAUAA 
                   
                 CAGCCC 
               
               
                   
                 
                   ACCCCU 
                 
                 GNGYATYRNTDFFG 
                 GGGCUCCGACGGCG 
                   
                 CUCCUC 
               
               
                   
                 
                   GCUCAG 
                 
                 LVDGLDFALQYQGK 
                 ACCAGACCUACAUG 
                   
                 CCCUUC 
               
               
                   
                 
                   CUGCUG 
                 
                 NGSVSGENTNGRSLL 
                 AGAAUCGGCUUCAA 
                   
                 CUGCAC 
               
               
                   
                 
                   UUCCUG 
                 
                 NQNGDGYGGSLTYAI 
                 GGGCGAGACACAAG 
                   
                 CCGUAC 
               
               
                   
                 
                   CUGCUG 
                 
                 GEGFSVGGAITTSKR 
                 UGAACGACCAGCUG 
                   
                 CCCCGU 
               
               
                   
                 
                   CUGUGG 
                 
                 TADQNNTANARLYG 
                 ACAGGCUACGGCCA 
                   
                 GGUCUU 
               
               
                   
                 
                   CUGCCU 
                 
                 NGDRATVYTGGLKY 
                 GUGGGAGUAUCAGA 
                   
                 UGAAUA 
               
               
                   
                 
                   GAUACA 
                 
                 DANNIYLAAQYSQTY 
                 UCCAGGGCAAUCAG 
                   
                 AAGUCU 
               
               
                   
                 
                   ACAGGC 
                 
                 NATRFGTSNGSNPST 
                 ACCGAGGGCAGCAA 
                   
                 GAGUGG 
               
               
                   
                 
                   (SEQ ID  
                 
                 SYGFANKAQNFEVV 
                 CGACAGCUGGACCA 
                   
                 GCGGC 
               
               
                   
                 
                   NO: 235) 
                 
                 AQYQFDFGLRPSVAY 
                 GAGUGGCUUUUGCC 
                   
                   
               
               
                   
                   
                 LQSKGKDISNGYGAS 
                 GGCCUGAAGUUUGC 
                   
                   
               
               
                   
                   
                 YGDQDIVKYVDVGA 
                 CGAUGCCGGCAGCU 
                   
                   
               
               
                   
                   
                 TYYFNKNMSTYVDY 
                 UUGACUACGGCAGA 
                   
                   
               
               
                   
                   
                 KINLLDKNDFTRDAG 
                 AAUUACGGCGUGAC 
                   
                   
               
               
                   
                   
                 INTDDIVALGLVYQF 
                 CUACGACGUGACCU 
                   
                   
               
               
                   
                   
                 HHHHHH 
                 CCUGGACAGAUGUG 
                   
                   
               
               
                   
                   
                   
                 CUGCCUGAGUUUGG 
                   
                   
               
               
                   
                   
                   
                 CGGCGAUACCUACG 
                   
                   
               
               
                   
                   
                   
                 GCGCCGACAACUUC 
                   
                   
               
               
                   
                   
                   
                 AUGCAGCAGAGAGG 
                   
                   
               
               
                   
                   
                   
                 CAACGGCUACGCCA 
                   
                   
               
               
                   
                   
                   
                 CCUACCGGAACACC 
                   
                   
               
               
                   
                   
                   
                 GAUUUCUUCGGCCU 
                   
                   
               
               
                   
                   
                   
                 GGUGGAUGGCCUGG 
                   
                   
               
               
                   
                   
                   
                 AUUUCGCCCUGCAG 
                   
                   
               
               
                   
                   
                   
                 UACCAGGGCAAGAA 
                   
                   
               
               
                   
                   
                   
                 UGGCUCUGUGUCCG 
                   
                   
               
               
                   
                   
                   
                 GCGAGAACACCAAC 
                   
                   
               
               
                   
                   
                   
                 GGCAGAAGCCUGCU 
                   
                   
               
               
                   
                   
                   
                 GAACCAGAACGGCG 
                   
                   
               
               
                   
                   
                   
                 ACGGAUAUGGCGGC 
                   
                   
               
               
                   
                   
                   
                 AGCCUGACAUAUGC 
                   
                   
               
               
                   
                   
                   
                 CAUCGGCGAGGGCU 
                   
                   
               
               
                   
                   
                   
                 UUUCUGUCGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCCAUCACCACCAG 
                   
                   
               
               
                   
                   
                   
                 CAAGAGAACAGCCG 
                   
                   
               
               
                   
                   
                   
                 ACCAGAACAACACC 
                   
                   
               
               
                   
                   
                   
                 GCCAACGCCAGACU 
                   
                   
               
               
                   
                   
                   
                 GUACGGCAACGGCG 
                   
                   
               
               
                   
                   
                   
                 AUAGAGCCACAGUG 
                   
                   
               
               
                   
                   
                   
                 UAUACCGGCGGACU 
                   
                   
               
               
                   
                   
                   
                 GAAGUACGACGCCA 
                   
                   
               
               
                   
                   
                   
                 ACAACAUCUACCUG 
                   
                   
               
               
                   
                   
                   
                 GCCGCUCAGUACAG 
                   
                   
               
               
                   
                   
                   
                 CCAGACAUACAACG 
                   
                   
               
               
                   
                   
                   
                 CCACCAGAUUCGGC 
                   
                   
               
               
                   
                   
                   
                 ACCAGCAACGGCAG 
                   
                   
               
               
                   
                   
                   
                 CAAUCCCAGCACAA 
                   
                   
               
               
                   
                   
                   
                 GCUACGGCUUCGCC 
                   
                   
               
               
                   
                   
                   
                 AACAAGGCCCAGAA 
                   
                   
               
               
                   
                   
                   
                 CUUUGAGGUGGUGG 
                   
                   
               
               
                   
                   
                   
                 CCCAGUACCAGUUC 
                   
                   
               
               
                   
                   
                   
                 GACUUCGGACUGAG 
                   
                   
               
               
                   
                   
                   
                 GCCUAGCGUGGCCU 
                   
                   
               
               
                   
                   
                   
                 ACCUGCAGAGCAAG 
                   
                   
               
               
                   
                   
                   
                 GGCAAAGACAUCAG 
                   
                   
               
               
                   
                   
                   
                 CAACGGAUACGGCG 
                   
                   
               
               
                   
                   
                   
                 CCAGCUACGGCGAU 
                   
                   
               
               
                   
                   
                   
                 CAGGACAUCGUGAA 
                   
                   
               
               
                   
                   
                   
                 AUACGUGGACGUGG 
                   
                   
               
               
                   
                   
                   
                 GCGCCACCUAUUAC 
                   
                   
               
               
                   
                   
                   
                 UUCAACAAGAACAU 
                   
                   
               
               
                   
                   
                   
                 GAGCACCUACGUGG 
                   
                   
               
               
                   
                   
                   
                 ACUACAAGAUCAAC 
                   
                   
               
               
                   
                   
                   
                 CUGCUGGACAAGAA 
                   
                   
               
               
                   
                   
                   
                 CGACUUCACCCGCG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGGCAUCAAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAUGAUAUUGU 
                   
                   
               
               
                   
                   
                   
                 GGCCCUGGGCCUCG 
                   
                   
               
               
                   
                   
                   
                 UGUACCAGUUUCAC 
                   
                   
               
               
                   
                   
                   
                 CACCACCAUCACCA 
                   
                   
               
               
                   
                   
                   
                 U 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 5 
                 6 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 162 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 6, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpC_ 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK 
                   PDTTG AEIYNKDGNK 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 LDLFGKVDGLHYFSD 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 DKGSDGDQTYMRIG 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 FKGETQVNDQLTGY 
                   AGGC GCCGAGAUCU 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 GQWEYQIQGNQTEG 
                 ACAACAAGGACGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 SNDSWTRVAFAGLK 
                 AACAAGCUGGACCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 FADAGSFDYGRNYG 
                 GUUCGGCAAGGUGG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 VTYDVTSWTDVLPEF 
                 ACGGCCUGCACUAC 
                   
                 UCCCCC 
               
               
                   
                   
                 GGDTYGADNFMQQR 
                 UUCAGCGACGAUAA 
                   
                 CAGCCC 
               
               
                   
                   
                 GNGYATYRNTDFFG 
                 GGGCUCCGACGGCG 
                   
                 CUCCUC 
               
               
                   
                   
                 LVDGLDFALQYQGK 
                 ACCAGACCUACAUG 
                   
                 CCCUUC 
               
               
                   
                   
                 NGSVSGENTNGRSLL 
                 AGAAUCGGCUUCAA 
                   
                 CUGCAC 
               
               
                   
                   
                 NQNGDGYGGSLTYAI 
                 GGGCGAGACACAAG 
                   
                 CCGUAC 
               
               
                   
                   
                 GEGFSVGGAITTSKR 
                 UGAACGACCAGCUG 
                   
                 CCCCGU 
               
               
                   
                   
                 TADQNNTANARLYG 
                 ACAGGCUACGGCCA 
                   
                 GGUCUU 
               
               
                   
                   
                 NGDRATVYTGGLKY 
                 GUGGGAGUAUCAGA 
                   
                 UGAAUA 
               
               
                   
                   
                 DANNIYLAAQYSQTY 
                 UCCAGGGCAAUCAG 
                   
                 AAGUCU 
               
               
                   
                   
                 NATRFGTSNGSNPST 
                 ACCGAGGGCAGCAA 
                   
                 GAGUGG 
               
               
                   
                   
                 SYGFANKAQNFEVV 
                 CGACAGCUGGACCA 
                   
                 GCGGC 
               
               
                   
                   
                 AQYQFDFGLRPSVAY 
                 GAGUGGCUUUUGCC 
                   
                   
               
               
                   
                   
                 LQSKGKDISNGYGAS 
                 GGCCUGAAGUUUGC 
                   
                   
               
               
                   
                   
                 YGDQDIVKYVDVGA 
                 CGAUGCCGGCAGCU 
                   
                   
               
               
                   
                   
                 TYYFNKNMSTYVDY 
                 UUGACUACGGCAGA 
                   
                   
               
               
                   
                   
                 KINLLDKNDFTRDAG 
                 AAUUACGGCGUGAC 
                   
                   
               
               
                   
                   
                 INTDDIVALGLVYQF 
                 CUACGACGUGACCU 
                   
                   
               
               
                   
                   
                   
                 CCUGGACAGAUGUG 
                   
                   
               
               
                   
                   
                   
                 CUGCCUGAGUUUGG 
                   
                   
               
               
                   
                   
                   
                 CGGCGAUACCUACG 
                   
                   
               
               
                   
                   
                   
                 GCGCCGACAACUUC 
                   
                   
               
               
                   
                   
                   
                 AUGCAGCAGAGAGG 
                   
                   
               
               
                   
                   
                   
                 CAACGGCUACGCCA 
                   
                   
               
               
                   
                   
                   
                 CCUACCGGAACACC 
                   
                   
               
               
                   
                   
                   
                 GAUUUCUUCGGCCU 
                   
                   
               
               
                   
                   
                   
                 GGUGGAUGGCCUGG 
                   
                   
               
               
                   
                   
                   
                 AUUUCGCCCUGCAG 
                   
                   
               
               
                   
                   
                   
                 UACCAGGGCAAGAA 
                   
                   
               
               
                   
                   
                   
                 UGGCUCUGUGUCCG 
                   
                   
               
               
                   
                   
                   
                 GCGAGAACACCAAC 
                   
                   
               
               
                   
                   
                   
                 GGCAGAAGCCUGCU 
                   
                   
               
               
                   
                   
                   
                 GAACCAGAACGGCG 
                   
                   
               
               
                   
                   
                   
                 ACGGAUAUGGCGGC 
                   
                   
               
               
                   
                   
                   
                 AGCCUGACAUAUGC 
                   
                   
               
               
                   
                   
                   
                 CAUCGGCGAGGGCU 
                   
                   
               
               
                   
                   
                   
                 UUUCUGUCGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCCAUCACCACCAG 
                   
                   
               
               
                   
                   
                   
                 CAAGAGAACAGCCG 
                   
                   
               
               
                   
                   
                   
                 ACCAGAACAACACC 
                   
                   
               
               
                   
                   
                   
                 GCCAACGCCAGACU 
                   
                   
               
               
                   
                   
                   
                 GUACGGCAACGGCG 
                   
                   
               
               
                   
                   
                   
                 AUAGAGCCACAGUG 
                   
                   
               
               
                   
                   
                   
                 UAUACCGGCGGACU 
                   
                   
               
               
                   
                   
                   
                 GAAGUACGACGCCA 
                   
                   
               
               
                   
                   
                   
                 ACAACAUCUACCUG 
                   
                   
               
               
                   
                   
                   
                 GCCGCUCAGUACAG 
                   
                   
               
               
                   
                   
                   
                 CCAGACAUACAACG 
                   
                   
               
               
                   
                   
                   
                 CCACCAGAUUCGGC 
                   
                   
               
               
                   
                   
                   
                 ACCAGCAACGGCAG 
                   
                   
               
               
                   
                   
                   
                 CAAUCCCAGCACAA 
                   
                   
               
               
                   
                   
                   
                 GCUACGGCUUCGCC 
                   
                   
               
               
                   
                   
                   
                 AACAAGGCCCAGAA 
                   
                   
               
               
                   
                   
                   
                 CUUUGAGGUGGUGG 
                   
                   
               
               
                   
                   
                   
                 CCCAGUACCAGUUC 
                   
                   
               
               
                   
                   
                   
                 GACUUCGGACUGAG 
                   
                   
               
               
                   
                   
                   
                 GCCUAGCGUGGCCU 
                   
                   
               
               
                   
                   
                   
                 ACCUGCAGAGCAAG 
                   
                   
               
               
                   
                   
                   
                 GGCAAAGACAUCAG 
                   
                   
               
               
                   
                   
                   
                 CAACGGAUACGGCG 
                   
                   
               
               
                   
                   
                   
                 CCAGCUACGGCGAU 
                   
                   
               
               
                   
                   
                   
                 CAGGACAUCGUGAA 
                   
                   
               
               
                   
                   
                   
                 AUACGUGGACGUGG 
                   
                   
               
               
                   
                   
                   
                 GCGCCACCUAUUAC 
                   
                   
               
               
                   
                   
                   
                 UUCAACAAGAACAU 
                   
                   
               
               
                   
                   
                   
                 GAGCACCUACGUGG 
                   
                   
               
               
                   
                   
                   
                 ACUACAAGAUCAAC 
                   
                   
               
               
                   
                   
                   
                 CUGCUGGACAAGAA 
                   
                   
               
               
                   
                   
                   
                 CGACUUCACCCGCG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGGCAUCAAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAUGAUAUUGU 
                   
                   
               
               
                   
                   
                   
                 GGCCCUGGGCCUCG 
                   
                   
               
               
                   
                   
                   
                 UGUACCAGUUU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 7 
                 8 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 163 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 8, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpF_ 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK_cHis 
                   PDTTG AEIYNKDGNK 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 variant 
                 LDLYGKAVGRHVWT 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 TTGDSKNADQTYAQI 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 GFKGETQINTDLTGF 
                   AGGC GCCGAGAUCU 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 GQWEYRTKADRAEG 
                 ACAACAAGGACGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 EQQNSNLVRLAFAGL 
                 AACAAGCUGGACCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 KYAEVGSIDYGRNY 
                 GUACGGCAAAGCCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 GIVYDVESYTDMAPY 
                 UGGGCAGACACGUG 
                   
                 UCCCCC 
               
               
                   
                   
                 FSGETWGGAYTDNY 
                 UGGACAACCACCGG 
                   
                 CAGCCC 
               
               
                   
                   
                 MTSRAGGLLTYRNS 
                 CGAUAGCAAGAACG 
                   
                 CUCCUC 
               
               
                   
                   
                 DFFGLVDGLSFGIQY 
                 CCGACCAGACAUAU 
                   
                 CCCUUC 
               
               
                   
                   
                 QGKNQDNHSINSQN 
                 GCCCAGAUCGGCUU 
                   
                 CUGCAC 
               
               
                   
                   
                 GDGVGYTMAYEFDG 
                 CAAGGGCGAGACAC 
                   
                 CCGUAC 
               
               
                   
                   
                 FGVTAAYSNSKRTND 
                 AGAUCAACACCGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 QQDRDGNGDRAESW 
                 CUGACCGGCUUUGG 
                   
                 GGUCUU 
               
               
                   
                   
                 AVGAKYDANNVYLA 
                 CCAGUGGGAGUACA 
                   
                 UGAAUA 
               
               
                   
                   
                 AVYAETRNMSIVENT 
                 GAACAAAGGCCGAC 
                   
                 AAGUCU 
               
               
                   
                   
                 VTDTVEMANKTQNL 
                 AGAGCCGAGGGCGA 
                   
                 GAGUGG 
               
               
                   
                   
                 EVVAQYQFDFGLRPA 
                 GCAGCAGAAUUCUA 
                   
                 GCGGC 
               
               
                   
                   
                 ISYVQSKGKQLNGAD 
                 AUCUUGUGCGGCUG 
                   
                   
               
               
                   
                   
                 GSADLAKYIQAGATY 
                 GCCUUCGCCGGCCU 
                   
                   
               
               
                   
                   
                 YFNKNMNVWVDYR 
                 GAAGUAUGCUGAAG 
                   
                   
               
               
                   
                   
                 FNLLDENDYSSSYVG 
                 UGGGCAGCAUCGAC 
                   
                   
               
               
                   
                   
                 TDDQAAVGITYQFHH 
                 UACGGCCGGAAUUA 
                   
                   
               
               
                   
                   
                 HHHH 
                 CGGCAUCGUGUACG 
                   
                   
               
               
                   
                   
                   
                 ACGUGGAAAGCUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGACAUGGCCCC 
                   
                   
               
               
                   
                   
                   
                 UUACUUCAGCGGCG 
                   
                   
               
               
                   
                   
                   
                 AAACAUGGGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCCUACACCGAUAA 
                   
                   
               
               
                   
                   
                   
                 CUACAUGACCAGCA 
                   
                   
               
               
                   
                   
                   
                 GAGCCGGCGGACUG 
                   
                   
               
               
                   
                   
                   
                 CUGACCUACAGAAA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAUUUCUUCG 
                   
                   
               
               
                   
                   
                   
                 GCCUGGUGGACGGC 
                   
                   
               
               
                   
                   
                   
                 CUGAGCUUCGGCAU 
                   
                   
               
               
                   
                   
                   
                 UCAGUACCAGGGCA 
                   
                   
               
               
                   
                   
                   
                 AGAACCAGGACAAU 
                   
                   
               
               
                   
                   
                   
                 CACAGCAUCAACAG 
                   
                   
               
               
                   
                   
                   
                 CCAGAACGGCGACG 
                   
                   
               
               
                   
                   
                   
                 GCGUGGGCUACACA 
                   
                   
               
               
                   
                   
                   
                 AUGGCCUACGAGUU 
                   
                   
               
               
                   
                   
                   
                 CGAUGGCUUUGGCG 
                   
                   
               
               
                   
                   
                   
                 UGACAGCCGCCUAC 
                   
                   
               
               
                   
                   
                   
                 AGCAACUCCAAGAG 
                   
                   
               
               
                   
                   
                   
                 GACCAACGACCAGC 
                   
                   
               
               
                   
                   
                   
                 AGGACAGAGAUGGC 
                   
                   
               
               
                   
                   
                   
                 AACGGCGAUAGAGC 
                   
                   
               
               
                   
                   
                   
                 CGAAUCUUGGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGGGCGCCAAAUAC 
                   
                   
               
               
                   
                   
                   
                 GACGCCAACAAUGU 
                   
                   
               
               
                   
                   
                   
                 GUAUCUGGCCGCCG 
                   
                   
               
               
                   
                   
                   
                 UGUACGCCGAGACA 
                   
                   
               
               
                   
                   
                   
                 CGGAACAUGAGCAU 
                   
                   
               
               
                   
                   
                   
                 CGUGGAGAACACCG 
                   
                   
               
               
                   
                   
                   
                 UGACCGACACCGUG 
                   
                   
               
               
                   
                   
                   
                 GAAAUGGCCAACAA 
                   
                   
               
               
                   
                   
                   
                 GACCCAGAACCUGG 
                   
                   
               
               
                   
                   
                   
                 AAGUGGUGGCCCAG 
                   
                   
               
               
                   
                   
                   
                 UACCAGUUCGACUU 
                   
                   
               
               
                   
                   
                   
                 UGGACUGAGGCCCG 
                   
                   
               
               
                   
                   
                   
                 CCAUCAGCUACGUG 
                   
                   
               
               
                   
                   
                   
                 CAGUCUAAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 GCAGCUGAAUGGCG 
                   
                   
               
               
                   
                   
                   
                 CCGAUGGCUCUGCA 
                   
                   
               
               
                   
                   
                   
                 GACCUGGCCAAGUA 
                   
                   
               
               
                   
                   
                   
                 UAUUCAGGCUGGCG 
                   
                   
               
               
                   
                   
                   
                 CCACCUACUACUUC 
                   
                   
               
               
                   
                   
                   
                 AACAAGAACAUGAA 
                   
                   
               
               
                   
                   
                   
                 CGUGUGGGUCGACU 
                   
                   
               
               
                   
                   
                   
                 ACCGGUUCAACCUG 
                   
                   
               
               
                   
                   
                   
                 CUGGACGAGAACGA 
                   
                   
               
               
                   
                   
                   
                 CUACAGCAGCUCCU 
                   
                   
               
               
                   
                   
                   
                 ACGUGGGCACCGAU 
                   
                   
               
               
                   
                   
                   
                 GAUCAGGCCGCUGU 
                   
                   
               
               
                   
                   
                   
                 GGGCAUCACCUACC 
                   
                   
               
               
                   
                   
                   
                 AGUUCCACCACCAC 
                   
                   
               
               
                   
                   
                   
                 CAUCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 9 
                 10 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 164 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 10, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpF_ 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK 
                   PDTTG AEIYNKDGNK 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 variant 
                 LDLYGKAVGRHVWT 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 TTGDSKNADQTYAQI 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 GFKGETQINTDLTGF 
                   AGGC GCCGAGAUCU 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 GQWEYRTKADRAEG 
                 ACAACAAGGACGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 EQQNSNLVRLAFAGL 
                 AACAAGCUGGACCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 KYAEVGSIDYGRNY 
                 GUACGGCAAAGCCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 GIVYDVESYTDMAPY 
                 UGGGCAGACACGUG 
                   
                 UCCCCC 
               
               
                   
                   
                 FSGETWGGAYTDNY 
                 UGGACAACCACCGG 
                   
                 CAGCCC 
               
               
                   
                   
                 MTSRAGGLLTYRNS 
                 CGAUAGCAAGAACG 
                   
                 CUCCUC 
               
               
                   
                   
                 DFFGLVDGLSFGIQY 
                 CCGACCAGACAUAU 
                   
                 CCCUUC 
               
               
                   
                   
                 QGKNQDNHSINSQN 
                 GCCCAGAUCGGCUU 
                   
                 CUGCAC 
               
               
                   
                   
                 GDGVGYTMAYEFDG 
                 CAAGGGCGAGACAC 
                   
                 CCGUAC 
               
               
                   
                   
                 FGVTAAYSNSKRTND 
                 AGAUCAACACCGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 QQDRDGNGDRAESW 
                 CUGACCGGCUUUGG 
                   
                 GGUCUU 
               
               
                   
                   
                 AVGAKYDANNVYLA 
                 CCAGUGGGAGUACA 
                   
                 UGAAUA 
               
               
                   
                   
                 AVYAETRNMSIVENT 
                 GAACAAAGGCCGAC 
                   
                 AAGUCU 
               
               
                   
                   
                 VTDTVEMANKTQNL 
                 AGAGCCGAGGGCGA 
                   
                 GAGUGG 
               
               
                   
                   
                 EVVAQYQFDFGLRPA 
                 GCAGCAGAAUUCUA 
                   
                 GCGGC 
               
               
                   
                   
                 ISYVQSKGKQLNGAD 
                 AUCUUGUGCGGCUG 
                   
                   
               
               
                   
                   
                 GSADLAKYIQAGATY 
                 GCCUUCGCCGGCCU 
                   
                   
               
               
                   
                   
                 YFNKNMNVWVDYR 
                 GAAGUAUGCUGAAG 
                   
                   
               
               
                   
                   
                 FNLLDENDYSSSYVG 
                 UGGGCAGCAUCGAC 
                   
                   
               
               
                   
                   
                 TDDQAAVGITYQF 
                 UACGGCCGGAAUUA 
                   
                   
               
               
                   
                   
                   
                 CGGCAUCGUGUACG 
                   
                   
               
               
                   
                   
                   
                 ACGUGGAAAGCUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGACAUGGCCCC 
                   
                   
               
               
                   
                   
                   
                 UUACUUCAGCGGCG 
                   
                   
               
               
                   
                   
                   
                 AAACAUGGGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCCUACACCGAUAA 
                   
                   
               
               
                   
                   
                   
                 CUACAUGACCAGCA 
                   
                   
               
               
                   
                   
                   
                 GAGCCGGCGGACUG 
                   
                   
               
               
                   
                   
                   
                 CUGACCUACAGAAA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAUUUCUUCG 
                   
                   
               
               
                   
                   
                   
                 GCCUGGUGGACGGC 
                   
                   
               
               
                   
                   
                   
                 CUGAGCUUCGGCAU 
                   
                   
               
               
                   
                   
                   
                 UCAGUACCAGGGCA 
                   
                   
               
               
                   
                   
                   
                 AGAACCAGGACAAU 
                   
                   
               
               
                   
                   
                   
                 CACAGCAUCAACAG 
                   
                   
               
               
                   
                   
                   
                 CCAGAACGGCGACG 
                   
                   
               
               
                   
                   
                   
                 GCGUGGGCUACACA 
                   
                   
               
               
                   
                   
                   
                 AUGGCCUACGAGUU 
                   
                   
               
               
                   
                   
                   
                 CGAUGGCUUUGGCG 
                   
                   
               
               
                   
                   
                   
                 UGACAGCCGCCUAC 
                   
                   
               
               
                   
                   
                   
                 AGCAACUCCAAGAG 
                   
                   
               
               
                   
                   
                   
                 GACCAACGACCAGC 
                   
                   
               
               
                   
                   
                   
                 AGGACAGAGAUGGC 
                   
                   
               
               
                   
                   
                   
                 AACGGCGAUAGAGC 
                   
                   
               
               
                   
                   
                   
                 CGAAUCUUGGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGGGCGCCAAAUAC 
                   
                   
               
               
                   
                   
                   
                 GACGCCAACAAUGU 
                   
                   
               
               
                   
                   
                   
                 GUAUCUGGCCGCCG 
                   
                   
               
               
                   
                   
                   
                 UGUACGCCGAGACA 
                   
                   
               
               
                   
                   
                   
                 CGGAACAUGAGCAU 
                   
                   
               
               
                   
                   
                   
                 CGUGGAGAACACCG 
                   
                   
               
               
                   
                   
                   
                 UGACCGACACCGUG 
                   
                   
               
               
                   
                   
                   
                 GAAAUGGCCAACAA 
                   
                   
               
               
                   
                   
                   
                 GACCCAGAACCUGG 
                   
                   
               
               
                   
                   
                   
                 AAGUGGUGGCCCAG 
                   
                   
               
               
                   
                   
                   
                 UACCAGUUCGACUU 
                   
                   
               
               
                   
                   
                   
                 UGGACUGAGGCCCG 
                   
                   
               
               
                   
                   
                   
                 CCAUCAGCUACGUG 
                   
                   
               
               
                   
                   
                   
                 CAGUCUAAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 GCAGCUGAAUGGCG 
                   
                   
               
               
                   
                   
                   
                 CCGAUGGCUCUGCA 
                   
                   
               
               
                   
                   
                   
                 GACCUGGCCAAGUA 
                   
                   
               
               
                   
                   
                   
                 UAUUCAGGCUGGCG 
                   
                   
               
               
                   
                   
                   
                 CCACCUACUACUUC 
                   
                   
               
               
                   
                   
                   
                 AACAAGAACAUGAA 
                   
                   
               
               
                   
                   
                   
                 CGUGUGGGUCGACU 
                   
                   
               
               
                   
                   
                   
                 ACCGGUUCAACCUG 
                   
                   
               
               
                   
                   
                   
                 CUGGACGAGAACGA 
                   
                   
               
               
                   
                   
                   
                 CUACAGCAGCUCCU 
                   
                   
               
               
                   
                   
                   
                 ACGUGGGCACCGAU 
                   
                   
               
               
                   
                   
                   
                 GAUCAGGCCGCUGU 
                   
                   
               
               
                   
                   
                   
                 GGGCAUCACCUACC 
                   
                   
               
               
                   
                   
                   
                 AGUUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 11 
                 12 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 165 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 12, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpF_ 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                   PDTTG AEIYNKDGNK 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 K_cHis 
                 LDLYGKAVGRHVWT 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                 variant 
                 TTGDSKNADQTYAQI 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 GFKGETQINTDLTGF 
                   AGGC GCCGAGAUCU 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 GQWEYRTKADRAEG 
                 ACAACAAGGACGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 EQQNSNLVRLAFAGL 
                 AACAAGCUGGACCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 KYAEVGSIDYGRNY 
                 GUACGGCAAAGCCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 GIVYDVESYTDMAPY 
                 UGGGCAGACACGUG 
                   
                 UCCCCC 
               
               
                   
                   
                 FSGETWGGAYTDNY 
                 UGGACAACCACCGG 
                   
                 CAGCCC 
               
               
                   
                   
                 MTSRAGGLLTYRNS 
                 CGAUAGCAAGAACG 
                   
                 CUCCUC 
               
               
                   
                   
                 DFFGLVDGLSFGIQY 
                 CCGACCAGACAUAU 
                   
                 CCCUUC 
               
               
                   
                   
                 QGKNQDNHSINSQN 
                 GCCCAGAUCGGCUU 
                   
                 CUGCAC 
               
               
                   
                   
                 GDGVGYTMAYEFDG 
                 CAAGGGCGAGACAC 
                   
                 CCGUAC 
               
               
                   
                   
                 FGVTAAYSNSKRTND 
                 AGAUCAACACCGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 QQDRDGNGDRAESW 
                 CUGACCGGCUUUGG 
                   
                 GGUCUU 
               
               
                   
                   
                 AVGAKYDANNVYLA 
                 CCAGUGGGAGUACA 
                   
                 UGAAUA 
               
               
                   
                   
                 AVYAETRNMAIVEN 
                 GAACAAAGGCCGAC 
                   
                 AAGUCU 
               
               
                   
                   
                 TVTDTVEMANKAQN 
                 AGAGCCGAGGGCGA 
                   
                 GAGUGG 
               
               
                   
                   
                 LEVVAQYQFDFGLRP 
                 GCAGCAGAAUUCUA 
                   
                 GCGGC 
               
               
                   
                   
                 AISYVQSKGKQLNGA 
                 AUCUUGUGCGGCUG 
                   
                   
               
               
                   
                   
                 DGSADLAKYIQAGAT 
                 GCCUUCGCCGGCCU 
                   
                   
               
               
                   
                   
                 YYFNKNMNVWVDY 
                 GAAGUAUGCUGAAG 
                   
                   
               
               
                   
                   
                 RFNLLDENDYSSSYV 
                 UGGGCAGCAUCGAC 
                   
                   
               
               
                   
                   
                 GTDDQAAVGITYQFH 
                 UACGGCCGGAAUUA 
                   
                   
               
               
                   
                   
                 HHHHH 
                 CGGCAUCGUGUACG 
                   
                   
               
               
                   
                   
                   
                 ACGUGGAAAGCUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGACAUGGCCCC 
                   
                   
               
               
                   
                   
                   
                 UUACUUCAGCGGCG 
                   
                   
               
               
                   
                   
                   
                 AAACAUGGGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCCUACACCGAUAA 
                   
                   
               
               
                   
                   
                   
                 CUACAUGACCAGCA 
                   
                   
               
               
                   
                   
                   
                 GAGCCGGCGGACUG 
                   
                   
               
               
                   
                   
                   
                 CUGACCUACAGAAA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAUUUCUUCG 
                   
                   
               
               
                   
                   
                   
                 GCCUGGUGGACGGC 
                   
                   
               
               
                   
                   
                   
                 CUGAGCUUCGGCAU 
                   
                   
               
               
                   
                   
                   
                 UCAGUACCAGGGCA 
                   
                   
               
               
                   
                   
                   
                 AGAACCAGGACAAU 
                   
                   
               
               
                   
                   
                   
                 CACAGCAUCAACAG 
                   
                   
               
               
                   
                   
                   
                 CCAGAACGGCGACG 
                   
                   
               
               
                   
                   
                   
                 GCGUGGGCUACACA 
                   
                   
               
               
                   
                   
                   
                 AUGGCCUACGAGUU 
                   
                   
               
               
                   
                   
                   
                 CGAUGGCUUUGGCG 
                   
                   
               
               
                   
                   
                   
                 UGACAGCCGCCUAC 
                   
                   
               
               
                   
                   
                   
                 AGCAACUCCAAGAG 
                   
                   
               
               
                   
                   
                   
                 GACCAACGACCAGC 
                   
                   
               
               
                   
                   
                   
                 AGGACAGAGAUGGC 
                   
                   
               
               
                   
                   
                   
                 AACGGCGAUAGAGC 
                   
                   
               
               
                   
                   
                   
                 CGAAUCUUGGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGGGCGCCAAAUAC 
                   
                   
               
               
                   
                   
                   
                 GACGCCAACAAUGU 
                   
                   
               
               
                   
                   
                   
                 GUAUCUGGCCGCCG 
                   
                   
               
               
                   
                   
                   
                 UGUACGCCGAGACA 
                   
                   
               
               
                   
                   
                   
                 AGAAACAUGGCCAU 
                   
                   
               
               
                   
                   
                   
                 CGUGGAGAACACCG 
                   
                   
               
               
                   
                   
                   
                 UGACCGACACCGUG 
                   
                   
               
               
                   
                   
                   
                 GAAAUGGCCAACAA 
                   
                   
               
               
                   
                   
                   
                 GGCCCAGAACCUGG 
                   
                   
               
               
                   
                   
                   
                 AAGUGGUGGCCCAG 
                   
                   
               
               
                   
                   
                   
                 UACCAGUUCGACUU 
                   
                   
               
               
                   
                   
                   
                 UGGACUGAGGCCCG 
                   
                   
               
               
                   
                   
                   
                 CCAUCAGCUACGUG 
                   
                   
               
               
                   
                   
                   
                 CAGUCUAAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 GCAGCUGAAUGGCG 
                   
                   
               
               
                   
                   
                   
                 CCGAUGGCUCUGCA 
                   
                   
               
               
                   
                   
                   
                 GACCUGGCCAAGUA 
                   
                   
               
               
                   
                   
                   
                 UAUUCAGGCUGGCG 
                   
                   
               
               
                   
                   
                   
                 CCACCUACUACUUC 
                   
                   
               
               
                   
                   
                   
                 AACAAGAACAUGAA 
                   
                   
               
               
                   
                   
                   
                 CGUGUGGGUCGACU 
                   
                   
               
               
                   
                   
                   
                 ACCGGUUCAACCUG 
                   
                   
               
               
                   
                   
                   
                 CUGGACGAGAACGA 
                   
                   
               
               
                   
                   
                   
                 CUACAGCAGCUCCU 
                   
                   
               
               
                   
                   
                   
                 ACGUGGGCACCGAU 
                   
                   
               
               
                   
                   
                   
                 GAUCAGGCCGCUGU 
                   
                   
               
               
                   
                   
                   
                 GGGCAUCACCUACC 
                   
                   
               
               
                   
                   
                   
                 AGUUCCACCACCAC 
                   
                   
               
               
                   
                   
                   
                 CAUCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 13 
                 14 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 166 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 14, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpF_ 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                   PDTTG AEIYNKDGNK 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 K variant 
                 LDLYGKAVGRHVWT 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 TTGDSKNADQTYAQI 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 GFKGETQINTDLTGF 
                   AGGC GCCGAGAUCU 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 GQWEYRTKADRAEG 
                 ACAACAAGGACGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 EQQNSNLVRLAFAGL 
                 AACAAGCUGGACCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 KYAEVGSIDYGRNY 
                 GUACGGCAAAGCCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 GIVYDVESYTDMAPY 
                 UGGGCAGACACGUG 
                   
                 UCCCCC 
               
               
                   
                   
                 FSGETWGGAYTDNY 
                 UGGACAACCACCGG 
                   
                 CAGCCC 
               
               
                   
                   
                 MTSRAGGLLTYRNS 
                 CGAUAGCAAGAACG 
                   
                 CUCCUC 
               
               
                   
                   
                 DFFGLVDGLSFGIQY 
                 CCGACCAGACAUAU 
                   
                 CCCUUC 
               
               
                   
                   
                 QGKNQDNHSINSQN 
                 GCCCAGAUCGGCUU 
                   
                 CUGCAC 
               
               
                   
                   
                 GDGVGYTMAYEFDG 
                 CAAGGGCGAGACAC 
                   
                 CCGUAC 
               
               
                   
                   
                 FGVTAAYSNSKRTND 
                 AGAUCAACACCGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 QQDRDGNGDRAESW 
                 CUGACCGGCUUUGG 
                   
                 GGUCUU 
               
               
                   
                   
                 AVGAKYDANNVYLA 
                 CCAGUGGGAGUACA 
                   
                 UGAAUA 
               
               
                   
                   
                 AVYAETRNMAIVEN 
                 GAACAAAGGCCGAC 
                   
                 AAGUCU 
               
               
                   
                   
                 TVTDTVEMANKAQN 
                 AGAGCCGAGGGCGA 
                   
                 GAGUGG 
               
               
                   
                   
                 LEVVAQYQFDFGLRP 
                 GCAGCAGAAUUCUA 
                   
                 GCGGC 
               
               
                   
                   
                 AISYVQSKGKQLNGA 
                 AUCUUGUGCGGCUG 
                   
                   
               
               
                   
                   
                 DGSADLAKYIQAGAT 
                 GCCUUCGCCGGCCU 
                   
                   
               
               
                   
                   
                 YYFNKNMNVWVDY 
                 GAAGUAUGCUGAAG 
                   
                   
               
               
                   
                   
                 RFNLLDENDYSSSYV 
                 UGGGCAGCAUCGAC 
                   
                   
               
               
                   
                   
                 GTDDQAAVGITYQF 
                 UACGGCCGGAAUUA 
                   
                   
               
               
                   
                   
                   
                 CGGCAUCGUGUACG 
                   
                   
               
               
                   
                   
                   
                 ACGUGGAAAGCUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGACAUGGCCCC 
                   
                   
               
               
                   
                   
                   
                 UUACUUCAGCGGCG 
                   
                   
               
               
                   
                   
                   
                 AAACAUGGGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCCUACACCGAUAA 
                   
                   
               
               
                   
                   
                   
                 CUACAUGACCAGCA 
                   
                   
               
               
                   
                   
                   
                 GAGCCGGCGGACUG 
                   
                   
               
               
                   
                   
                   
                 CUGACCUACAGAAA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAUUUCUUCG 
                   
                   
               
               
                   
                   
                   
                 GCCUGGUGGACGGC 
                   
                   
               
               
                   
                   
                   
                 CUGAGCUUCGGCAU 
                   
                   
               
               
                   
                   
                   
                 UCAGUACCAGGGCA 
                   
                   
               
               
                   
                   
                   
                 AGAACCAGGACAAU 
                   
                   
               
               
                   
                   
                   
                 CACAGCAUCAACAG 
                   
                   
               
               
                   
                   
                   
                 CCAGAACGGCGACG 
                   
                   
               
               
                   
                   
                   
                 GCGUGGGCUACACA 
                   
                   
               
               
                   
                   
                   
                 AUGGCCUACGAGUU 
                   
                   
               
               
                   
                   
                   
                 CGAUGGCUUUGGCG 
                   
                   
               
               
                   
                   
                   
                 UGACAGCCGCCUAC 
                   
                   
               
               
                   
                   
                   
                 AGCAACUCCAAGAG 
                   
                   
               
               
                   
                   
                   
                 GACCAACGACCAGC 
                   
                   
               
               
                   
                   
                   
                 AGGACAGAGAUGGC 
                   
                   
               
               
                   
                   
                   
                 AACGGCGAUAGAGC 
                   
                   
               
               
                   
                   
                   
                 CGAAUCUUGGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGGGCGCCAAAUAC 
                   
                   
               
               
                   
                   
                   
                 GACGCCAACAAUGU 
                   
                   
               
               
                   
                   
                   
                 GUAUCUGGCCGCCG 
                   
                   
               
               
                   
                   
                   
                 UGUACGCCGAGACA 
                   
                   
               
               
                   
                   
                   
                 AGAAACAUGGCCAU 
                   
                   
               
               
                   
                   
                   
                 CGUGGAGAACACCG 
                   
                   
               
               
                   
                   
                   
                 UGACCGACACCGUG 
                   
                   
               
               
                   
                   
                   
                 GAAAUGGCCAACAA 
                   
                   
               
               
                   
                   
                   
                 GGCCCAGAACCUGG 
                   
                   
               
               
                   
                   
                   
                 AAGUGGUGGCCCAG 
                   
                   
               
               
                   
                   
                   
                 UACCAGUUCGACUU 
                   
                   
               
               
                   
                   
                   
                 UGGACUGAGGCCCG 
                   
                   
               
               
                   
                   
                   
                 CCAUCAGCUACGUG 
                   
                   
               
               
                   
                   
                   
                 CAGUCUAAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 GCAGCUGAAUGGCG 
                   
                   
               
               
                   
                   
                   
                 CCGAUGGCUCUGCA 
                   
                   
               
               
                   
                   
                   
                 GACCUGGCCAAGUA 
                   
                   
               
               
                   
                   
                   
                 UAUUCAGGCUGGCG 
                   
                   
               
               
                   
                   
                   
                 CCACCUACUACUUC 
                   
                   
               
               
                   
                   
                   
                 AACAAGAACAUGAA 
                   
                   
               
               
                   
                   
                   
                 CGUGUGGGUCGACU 
                   
                   
               
               
                   
                   
                   
                 ACCGGUUCAACCUG 
                   
                   
               
               
                   
                   
                   
                 CUGGACGAGAACGA 
                   
                   
               
               
                   
                   
                   
                 CUACAGCAGCUCCU 
                   
                   
               
               
                   
                   
                   
                 ACGUGGGCACCGAU 
                   
                   
               
               
                   
                   
                   
                 GAUCAGGCCGCUGU 
                   
                   
               
               
                   
                   
                   
                 GGGCAUCACCUACC 
                   
                   
               
               
                   
                   
                   
                 AGUUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 15 
                 16 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 167 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 16, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Stm_Omp 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 D_nIgK_c 
                   PDTTG AEVYNKDGN 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 His variant 
                 KLDLYGKVHAQHYF 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 SDDNGSDGDKTYAR 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 LGFKGETQINDQLTG 
                   AGGC GCCGAGGUGU 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 FGQWEYEFKGNRTES 
                 ACAACAAGGACGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 QGADKDKTRLAFAG 
                 AACAAGCUGGACCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LKFADYGSFDYGRN 
                 GUACGGCAAAGUGC 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 YGVAYDIGAWTDVL 
                 ACGCCCAGCACUAC 
                   
                 UCCCCC 
               
               
                   
                   
                 PEFGGDTWTQTDVF 
                 UUCAGCGACGACAA 
                   
                 CAGCCC 
               
               
                   
                   
                 MTGRTTGVATYRNT 
                 UGGCAGCGACGGCG 
                   
                 CUCCUC 
               
               
                   
                   
                 DFFGLVEGLNFAAQY 
                 ACAAGACAUAUGCC 
                   
                 CCCUUC 
               
               
                   
                   
                 QGKNDRDGAYESNG 
                 CGGCUUGGCUUCAA 
                   
                 CUGCAC 
               
               
                   
                   
                 DGFGLSATYEYEGFG 
                 GGGCGAGACACAGA 
                   
                 CCGUAC 
               
               
                   
                   
                 VGAAYAKSDRTNNQ 
                 UCAACGACCAGCUG 
                   
                 CCCCGU 
               
               
                   
                   
                 VKAASNLNAAGKNA 
                 ACCGGCUUUGGCCA 
                   
                 GGUCUU 
               
               
                   
                   
                 EVWAAGLKYDANNI 
                 GUGGGAGUACGAGU 
                   
                 UGAAUA 
               
               
                   
                   
                 YLATTYSETLNMTTF 
                 UCAAGGGCAACAGA 
                   
                 AAGUCU 
               
               
                   
                   
                 GEDAAGDAFIANKTQ 
                 ACCGAGAGCCAGGG 
                   
                 GAGUGG 
               
               
                   
                   
                 NFEAVAQYQFDFGLR 
                 CGCCGACAAGGACA 
                   
                 GCGGC 
               
               
                   
                   
                 PSIAYLKSKGKNLGT 
                 AGACCAGACUGGCC 
                   
                   
               
               
                   
                   
                 YGDQDLVEYIDVGA 
                 UUUGCCGGCCUGAA 
                   
                   
               
               
                   
                   
                 TYYFNKNMSTFVDY 
                 GUUCGCCGAUUACG 
                   
                   
               
               
                   
                   
                 KINLLDDSDFTKAAK 
                 GCAGCUUUGACUAC 
                   
                   
               
               
                   
                   
                 VSTDNIVAVGLNYQF 
                 GGCCGGAAUUACGG 
                   
                   
               
               
                   
                   
                 HHHHHH 
                 CGUGGCCUACGAUA 
                   
                   
               
               
                   
                   
                   
                 UCGGAGCCUGGACA 
                   
                   
               
               
                   
                   
                   
                 GAUGUGCUGCCUGA 
                   
                   
               
               
                   
                   
                   
                 GUUUGGCGGCGACA 
                   
                   
               
               
                   
                   
                   
                 CCUGGACACAGACC 
                   
                   
               
               
                   
                   
                   
                 GACGUGUUCAUGAC 
                   
                   
               
               
                   
                   
                   
                 CGGCAGAACAACUG 
                   
                   
               
               
                   
                   
                   
                 GCGUGGCCACCUAC 
                   
                   
               
               
                   
                   
                   
                 CGGAACACCGAUUU 
                   
                   
               
               
                   
                   
                   
                 CUUUGGCCUGGUGG 
                   
                   
               
               
                   
                   
                   
                 AAGGCCUGAACUUU 
                   
                   
               
               
                   
                   
                   
                 GCCGCUCAGUACCA 
                   
                   
               
               
                   
                   
                   
                 GGGCAAGAACGACA 
                   
                   
               
               
                   
                   
                   
                 GAGAUGGCGCCUAC 
                   
                   
               
               
                   
                   
                   
                 GAGUCUAACGGCGA 
                   
                   
               
               
                   
                   
                   
                 CGGCUUUGGACUGA 
                   
                   
               
               
                   
                   
                   
                 GCGCCACCUACGAG 
                   
                   
               
               
                   
                   
                   
                 UACGAAGGCUUUGG 
                   
                   
               
               
                   
                   
                   
                 AGUGGGCGCUGCCU 
                   
                   
               
               
                   
                   
                   
                 ACGCCAAGAGCGAC 
                   
                   
               
               
                   
                   
                   
                 AGGACCAACAAUCA 
                   
                   
               
               
                   
                   
                   
                 AGUGAAGGCCGCCA 
                   
                   
               
               
                   
                   
                   
                 GCAACCUGAACGCC 
                   
                   
               
               
                   
                   
                   
                 GCUGGAAAGAAUGC 
                   
                   
               
               
                   
                   
                   
                 CGAAGUGUGGGCCG 
                   
                   
               
               
                   
                   
                   
                 CUGGACUGAAGUAC 
                   
                   
               
               
                   
                   
                   
                 GACGCCAACAACAU 
                   
                   
               
               
                   
                   
                   
                 CUACCUGGCCACCA 
                   
                   
               
               
                   
                   
                   
                 CCUACAGCGAGACA 
                   
                   
               
               
                   
                   
                   
                 CUGAACAUGACCAC 
                   
                   
               
               
                   
                   
                   
                 CUUCGGCGAAGAUG 
                   
                   
               
               
                   
                   
                   
                 CCGCUGGCGACGCC 
                   
                   
               
               
                   
                   
                   
                 UUUAUCGCCAACAA 
                   
                   
               
               
                   
                   
                   
                 GACCCAGAACUUCG 
                   
                   
               
               
                   
                   
                   
                 AGGCUGUGGCCCAG 
                   
                   
               
               
                   
                   
                   
                 UACCAGUUCGACUU 
                   
                   
               
               
                   
                   
                   
                 CGGACUGAGGCCCU 
                   
                   
               
               
                   
                   
                   
                 CUAUCGCCUACCUG 
                   
                   
               
               
                   
                   
                   
                 AAGUCCAAGGGAAA 
                   
                   
               
               
                   
                   
                   
                 GAACCUGGGCACCU 
                   
                   
               
               
                   
                   
                   
                 ACGGCGACCAGGAC 
                   
                   
               
               
                   
                   
                   
                 CUGGUUGAGUAUAU 
                   
                   
               
               
                   
                   
                   
                 CGAUGUGGGAGCCA 
                   
                   
               
               
                   
                   
                   
                 CCUACUACUUCAAC 
                   
                   
               
               
                   
                   
                   
                 AAGAAUAUGAGCAC 
                   
                   
               
               
                   
                   
                   
                 CUUCGUGGACUACA 
                   
                   
               
               
                   
                   
                   
                 AGAUCAACCUGCUG 
                   
                   
               
               
                   
                   
                   
                 GACGACAGCGACUU 
                   
                   
               
               
                   
                   
                   
                 CACCAAAGCCGCCA 
                   
                   
               
               
                   
                   
                   
                 AGGUGUCCACCGAC 
                   
                   
               
               
                   
                   
                   
                 AACAUUGUGGCCGU 
                   
                   
               
               
                   
                   
                   
                 GGGCCUGAAUUACC 
                   
                   
               
               
                   
                   
                   
                 AGUUCCACCACCAC 
                   
                   
               
               
                   
                   
                   
                 CAUCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 17 
                 18 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 168 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 18, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Stm_Omp 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 D_nIgK 
                   PDTTG AEVYNKDGN 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 variant 
                 KLDLYGKVHAQHYF 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 SDDNGSDGDKTYAR 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 LGFKGETQINDQLTG 
                   AGGC GCCGAGGUGU 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 FGQWEYEFKGNRTES 
                 ACAACAAGGACGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 QGADKDKTRLAFAG 
                 AACAAGCUGGACCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LKFADYGSFDYGRN 
                 GUACGGCAAAGUGC 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 YGVAYDIGAWTDVL 
                 ACGCCCAGCACUAC 
                   
                 UCCCCC 
               
               
                   
                   
                 PEFGGDTWTQTDVF 
                 UUCAGCGACGACAA 
                   
                 CAGCCC 
               
               
                   
                   
                 MTGRTTGVATYRNT 
                 UGGCAGCGACGGCG 
                   
                 CUCCUC 
               
               
                   
                   
                 DFFGLVEGLNFAAQY 
                 ACAAGACAUAUGCC 
                   
                 CCCUUC 
               
               
                   
                   
                 QGKNDRDGAYESNG 
                 CGGCUUGGCUUCAA 
                   
                 CUGCAC 
               
               
                   
                   
                 DGFGLSATYEYEGFG 
                 GGGCGAGACACAGA 
                   
                 CCGUAC 
               
               
                   
                   
                 VGAAYAKSDRTNNQ 
                 UCAACGACCAGCUG 
                   
                 CCCCGU 
               
               
                   
                   
                 VKAASNLNAAGKNA 
                 ACCGGCUUUGGCCA 
                   
                 GGUCUU 
               
               
                   
                   
                 EVWAAGLKYDANNI 
                 GUGGGAGUACGAGU 
                   
                 UGAAUA 
               
               
                   
                   
                 YLATTYSETLNMTTF 
                 UCAAGGGCAACAGA 
                   
                 AAGUCU 
               
               
                   
                   
                 GEDAAGDAFIANKTQ 
                 ACCGAGAGCCAGGG 
                   
                 GAGUGG 
               
               
                   
                   
                 NFEAVAQYQFDFGLR 
                 CGCCGACAAGGACA 
                   
                 GCGGC 
               
               
                   
                   
                 PSIAYLKSKGKNLGT 
                 AGACCAGACUGGCC 
                   
                   
               
               
                   
                   
                 YGDQDLVEYIDVGA 
                 UUUGCCGGCCUGAA 
                   
                   
               
               
                   
                   
                 TYYFNKNMSTFVDY 
                 GUUCGCCGAUUACG 
                   
                   
               
               
                   
                   
                 KINLLDDSDFTKAAK 
                 GCAGCUUUGACUAC 
                   
                   
               
               
                   
                   
                 VSTDNIVAVGLNYQF 
                 GGCCGGAAUUACGG 
                   
                   
               
               
                   
                   
                   
                 CGUGGCCUACGAUA 
                   
                   
               
               
                   
                   
                   
                 UCGGAGCCUGGACA 
                   
                   
               
               
                   
                   
                   
                 GAUGUGCUGCCUGA 
                   
                   
               
               
                   
                   
                   
                 GUUUGGCGGCGACA 
                   
                   
               
               
                   
                   
                   
                 CCUGGACACAGACC 
                   
                   
               
               
                   
                   
                   
                 GACGUGUUCAUGAC 
                   
                   
               
               
                   
                   
                   
                 CGGCAGAACAACUG 
                   
                   
               
               
                   
                   
                   
                 GCGUGGCCACCUAC 
                   
                   
               
               
                   
                   
                   
                 CGGAACACCGAUUU 
                   
                   
               
               
                   
                   
                   
                 CUUUGGCCUGGUGG 
                   
                   
               
               
                   
                   
                   
                 AAGGCCUGAACUUU 
                   
                   
               
               
                   
                   
                   
                 GCCGCUCAGUACCA 
                   
                   
               
               
                   
                   
                   
                 GGGCAAGAACGACA 
                   
                   
               
               
                   
                   
                   
                 GAGAUGGCGCCUAC 
                   
                   
               
               
                   
                   
                   
                 GAGUCUAACGGCGA 
                   
                   
               
               
                   
                   
                   
                 CGGCUUUGGACUGA 
                   
                   
               
               
                   
                   
                   
                 GCGCCACCUACGAG 
                   
                   
               
               
                   
                   
                   
                 UACGAAGGCUUUGG 
                   
                   
               
               
                   
                   
                   
                 AGUGGGCGCUGCCU 
                   
                   
               
               
                   
                   
                   
                 ACGCCAAGAGCGAC 
                   
                   
               
               
                   
                   
                   
                 AGGACCAACAAUCA 
                   
                   
               
               
                   
                   
                   
                 AGUGAAGGCCGCCA 
                   
                   
               
               
                   
                   
                   
                 GCAACCUGAACGCC 
                   
                   
               
               
                   
                   
                   
                 GCUGGAAAGAAUGC 
                   
                   
               
               
                   
                   
                   
                 CGAAGUGUGGGCCG 
                   
                   
               
               
                   
                   
                   
                 CUGGACUGAAGUAC 
                   
                   
               
               
                   
                   
                   
                 GACGCCAACAACAU 
                   
                   
               
               
                   
                   
                   
                 CUACCUGGCCACCA 
                   
                   
               
               
                   
                   
                   
                 CCUACAGCGAGACA 
                   
                   
               
               
                   
                   
                   
                 CUGAACAUGACCAC 
                   
                   
               
               
                   
                   
                   
                 CUUCGGCGAAGAUG 
                   
                   
               
               
                   
                   
                   
                 CCGCUGGCGACGCC 
                   
                   
               
               
                   
                   
                   
                 UUUAUCGCCAACAA 
                   
                   
               
               
                   
                   
                   
                 GACCCAGAACUUCG 
                   
                   
               
               
                   
                   
                   
                 AGGCUGUGGCCCAG 
                   
                   
               
               
                   
                   
                   
                 UACCAGUUCGACUU 
                   
                   
               
               
                   
                   
                   
                 CGGACUGAGGCCCU 
                   
                   
               
               
                   
                   
                   
                 CUAUCGCCUACCUG 
                   
                   
               
               
                   
                   
                   
                 AAGUCCAAGGGAAA 
                   
                   
               
               
                   
                   
                   
                 GAACCUGGGCACCU 
                   
                   
               
               
                   
                   
                   
                 ACGGCGACCAGGAC 
                   
                   
               
               
                   
                   
                   
                 CUGGUUGAGUAUAU 
                   
                   
               
               
                   
                   
                   
                 CGAUGUGGGAGCCA 
                   
                   
               
               
                   
                   
                   
                 CCUACUACUUCAAC 
                   
                   
               
               
                   
                   
                   
                 AAGAAUAUGAGCAC 
                   
                   
               
               
                   
                   
                   
                 CUUCGUGGACUACA 
                   
                   
               
               
                   
                   
                   
                 AGAUCAACCUGCUG 
                   
                   
               
               
                   
                   
                   
                 GACGACAGCGACUU 
                   
                   
               
               
                   
                   
                   
                 CACCAAAGCCGCCA 
                   
                   
               
               
                   
                   
                   
                 AGGUGUCCACCGAC 
                   
                   
               
               
                   
                   
                   
                 AACAUUGUGGCCGU 
                   
                   
               
               
                   
                   
                   
                 GGGCCUGAAUUACC 
                   
                   
               
               
                   
                   
                   
                 AGUUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 19 
                 20 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 169 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 20, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpC_ 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                   PDTTG AEIYNKDGNK 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 k_cHis 
                 LDLFGKVDGLHYFSD 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 DKGSDGDQTYMRIG 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 FKGETQVNDQLTGY 
                   AGGC GCCGAGAUCU 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 GQWEYQIQGNQAEG 
                 ACAACAAGGACGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 SNDAWTRVAFAGLK 
                 AACAAGCUGGACCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 FADAGSFDYGRNYG 
                 GUUCGGCAAGGUGG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 VTYDVTSWTDVLPEF 
                 ACGGCCUGCACUAC 
                   
                 UCCCCC 
               
               
                   
                   
                 GGDTYGADNFMQQR 
                 UUCAGCGACGAUAA 
                   
                 CAGCCC 
               
               
                   
                   
                 GNGYATYRNTDFFG 
                 GGGCUCCGACGGCG 
                   
                 CUCCUC 
               
               
                   
                   
                 LVDGLDFALQYQGK 
                 ACCAGACCUACAUG 
                   
                 CCCUUC 
               
               
                   
                   
                 NGAVSGENTNGRSLL 
                 AGAAUCGGCUUCAA 
                   
                 CUGCAC 
               
               
                   
                   
                 NQNGDGYGGSLTYAI 
                 GGGCGAGACACAAG 
                   
                 CCGUAC 
               
               
                   
                   
                 GEGFSVGGAITTSKR 
                 UGAACGACCAGCUG 
                   
                 CCCCGU 
               
               
                   
                   
                 TADQNNAANARLYG 
                 ACAGGCUACGGCCA 
                   
                 GGUCUU 
               
               
                   
                   
                 NGDRATVYTGGLKY 
                 GUGGGAGUAUCAGA 
                   
                 UGAAUA 
               
               
                   
                   
                 DANNIYLAAQYSQTY 
                 UCCAGGGCAAUCAG 
                   
                 AAGUCU 
               
               
                   
                   
                 NAARFGTSNGANPST 
                 GCCGAGGGCAGCAA 
                   
                 GAGUGG 
               
               
                   
                   
                 SYGFANKAQNFEVV 
                 CGACGCAUGGACCA 
                   
                 GCGGC 
               
               
                   
                   
                 AQYQFDFGLRPSVAY 
                 GAGUGGCUUUUGCC 
                   
                   
               
               
                   
                   
                 LQSKGKDISNGYGAS 
                 GGCCUGAAGUUUGC 
                   
                   
               
               
                   
                   
                 YGDQDIVKYVDVGA 
                 CGAUGCCGGCAGCU 
                   
                   
               
               
                   
                   
                 TYYFNKNMSTYVDY 
                 UUGACUACGGCAGA 
                   
                   
               
               
                   
                   
                 KINLLDKNDFTRDAG 
                 AAUUACGGCGUGAC 
                   
                   
               
               
                   
                   
                 INTDDIVALGLVYQF 
                 CUACGACGUGACCU 
                   
                   
               
               
                   
                   
                 HHHHHH 
                 CCUGGACAGAUGUG 
                   
                   
               
               
                   
                   
                   
                 CUGCCUGAGUUUGG 
                   
                   
               
               
                   
                   
                   
                 CGGCGAUACCUACG 
                   
                   
               
               
                   
                   
                   
                 GCGCCGACAACUUC 
                   
                   
               
               
                   
                   
                   
                 AUGCAGCAGAGAGG 
                   
                   
               
               
                   
                   
                   
                 CAACGGCUACGCCA 
                   
                   
               
               
                   
                   
                   
                 CCUACCGGAACACC 
                   
                   
               
               
                   
                   
                   
                 GAUUUCUUCGGCCU 
                   
                   
               
               
                   
                   
                   
                 GGUGGAUGGCCUGG 
                   
                   
               
               
                   
                   
                   
                 AUUUCGCCCUGCAG 
                   
                   
               
               
                   
                   
                   
                 UACCAGGGCAAGAA 
                   
                   
               
               
                   
                   
                   
                 UGGCGCUGUGUCCG 
                   
                   
               
               
                   
                   
                   
                 GCGAGAACACCAAC 
                   
                   
               
               
                   
                   
                   
                 GGCAGAAGCCUGCU 
                   
                   
               
               
                   
                   
                   
                 GAACCAGAACGGCG 
                   
                   
               
               
                   
                   
                   
                 ACGGAUAUGGCGGC 
                   
                   
               
               
                   
                   
                   
                 AGCCUGACAUAUGC 
                   
                   
               
               
                   
                   
                   
                 CAUCGGCGAGGGCU 
                   
                   
               
               
                   
                   
                   
                 UUUCUGUCGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCCAUCACCACCAG 
                   
                   
               
               
                   
                   
                   
                 CAAGAGAACAGCCG 
                   
                   
               
               
                   
                   
                   
                 ACCAGAACAACGCC 
                   
                   
               
               
                   
                   
                   
                 GCCAACGCCAGACU 
                   
                   
               
               
                   
                   
                   
                 GUACGGCAACGGCG 
                   
                   
               
               
                   
                   
                   
                 AUAGAGCCACAGUG 
                   
                   
               
               
                   
                   
                   
                 UAUACCGGCGGACU 
                   
                   
               
               
                   
                   
                   
                 GAAGUACGACGCCA 
                   
                   
               
               
                   
                   
                   
                 ACAACAUCUACCUG 
                   
                   
               
               
                   
                   
                   
                 GCCGCUCAGUACAG 
                   
                   
               
               
                   
                   
                   
                 CCAGACAUACAACG 
                   
                   
               
               
                   
                   
                   
                 CCGCCAGAUUCGGC 
                   
                   
               
               
                   
                   
                   
                 ACCAGCAACGGCGC 
                   
                   
               
               
                   
                   
                   
                 AAAUCCCAGCACAA 
                   
                   
               
               
                   
                   
                   
                 GCUACGGCUUCGCC 
                   
                   
               
               
                   
                   
                   
                 AACAAGGCCCAGAA 
                   
                   
               
               
                   
                   
                   
                 CUUUGAGGUGGUGG 
                   
                   
               
               
                   
                   
                   
                 CCCAGUACCAGUUC 
                   
                   
               
               
                   
                   
                   
                 GACUUCGGACUGAG 
                   
                   
               
               
                   
                   
                   
                 GCCUAGCGUGGCCU 
                   
                   
               
               
                   
                   
                   
                 ACCUGCAGAGCAAG 
                   
                   
               
               
                   
                   
                   
                 GGCAAAGACAUCAG 
                   
                   
               
               
                   
                   
                   
                 CAACGGAUACGGCG 
                   
                   
               
               
                   
                   
                   
                 CCAGCUACGGCGAU 
                   
                   
               
               
                   
                   
                   
                 CAGGACAUCGUGAA 
                   
                   
               
               
                   
                   
                   
                 AUACGUGGACGUGG 
                   
                   
               
               
                   
                   
                   
                 GCGCCACCUAUUAC 
                   
                   
               
               
                   
                   
                   
                 UUCAACAAGAACAU 
                   
                   
               
               
                   
                   
                   
                 GAGCACCUACGUGG 
                   
                   
               
               
                   
                   
                   
                 ACUACAAGAUCAAC 
                   
                   
               
               
                   
                   
                   
                 CUGCUGGACAAGAA 
                   
                   
               
               
                   
                   
                   
                 CGACUUCACCCGCG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGGCAUCAAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAUGAUAUUGU 
                   
                   
               
               
                   
                   
                   
                 GGCCCUGGGCCUCG 
                   
                   
               
               
                   
                   
                   
                 UGUACCAGUUUCAC 
                   
                   
               
               
                   
                   
                   
                 CACCACCAUCACCA 
                   
                   
               
               
                   
                   
                   
                 U 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 21 
                 22 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 170 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 22, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpC_ 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                   PDTTG AEIYNKDGNK 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 k 
                 LDLFGKVDGLHYFSD 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 DKGSDGDQTYMRIG 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 FKGETQVNDQLTGY 
                   AGGC GCCGAGAUCU 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 GQWEYQIQGNQAEG 
                 ACAACAAGGACGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 SNDAWTRVAFAGLK 
                 AACAAGCUGGACCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 FADAGSFDYGRNYG 
                 GUUCGGCAAGGUGG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 VTYDVTSWTDVLPEF 
                 ACGGCCUGCACUAC 
                   
                 UCCCCC 
               
               
                   
                   
                 GGDTYGADNFMQQR 
                 UUCAGCGACGAUAA 
                   
                 CAGCCC 
               
               
                   
                   
                 GNGYATYRNTDFFG 
                 GGGCUCCGACGGCG 
                   
                 CUCCUC 
               
               
                   
                   
                 LVDGLDFALQYQGK 
                 ACCAGACCUACAUG 
                   
                 CCCUUC 
               
               
                   
                   
                 NGAVSGENTNGRSLL 
                 AGAAUCGGCUUCAA 
                   
                 CUGCAC 
               
               
                   
                   
                 NQNGDGYGGSLTYAI 
                 GGGCGAGACACAAG 
                   
                 CCGUAC 
               
               
                   
                   
                 GEGFSVGGAITTSKR 
                 UGAACGACCAGCUG 
                   
                 CCCCGU 
               
               
                   
                   
                 TADQNNAANARLYG 
                 ACAGGCUACGGCCA 
                   
                 GGUCUU 
               
               
                   
                   
                 NGDRATVYTGGLKY 
                 GUGGGAGUAUCAGA 
                   
                 UGAAUA 
               
               
                   
                   
                 DANNIYLAAQYSQTY 
                 UCCAGGGCAAUCAG 
                   
                 AAGUCU 
               
               
                   
                   
                 NAARFGTSNGANPST 
                 GCCGAGGGCAGCAA 
                   
                 GAGUGG 
               
               
                   
                   
                 SYGFANKAQNFEVV 
                 CGACGCAUGGACCA 
                   
                 GCGGC 
               
               
                   
                   
                 AQYQFDFGLRPSVAY 
                 GAGUGGCUUUUGCC 
                   
                   
               
               
                   
                   
                 LQSKGKDISNGYGAS 
                 GGCCUGAAGUUUGC 
                   
                   
               
               
                   
                   
                 YGDQDIVKYVDVGA 
                 CGAUGCCGGCAGCU 
                   
                   
               
               
                   
                   
                 TYYFNKNMSTYVDY 
                 UUGACUACGGCAGA 
                   
                   
               
               
                   
                   
                 KINLLDKNDFTRDAG 
                 AAUUACGGCGUGAC 
                   
                   
               
               
                   
                   
                 INTDDIVALGLVYQF 
                 CUACGACGUGACCU 
                   
                   
               
               
                   
                   
                   
                 CCUGGACAGAUGUG 
                   
                   
               
               
                   
                   
                   
                 CUGCCUGAGUUUGG 
                   
                   
               
               
                   
                   
                   
                 CGGCGAUACCUACG 
                   
                   
               
               
                   
                   
                   
                 GCGCCGACAACUUC 
                   
                   
               
               
                   
                   
                   
                 AUGCAGCAGAGAGG 
                   
                   
               
               
                   
                   
                   
                 CAACGGCUACGCCA 
                   
                   
               
               
                   
                   
                   
                 CCUACCGGAACACC 
                   
                   
               
               
                   
                   
                   
                 GAUUUCUUCGGCCU 
                   
                   
               
               
                   
                   
                   
                 GGUGGAUGGCCUGG 
                   
                   
               
               
                   
                   
                   
                 AUUUCGCCCUGCAG 
                   
                   
               
               
                   
                   
                   
                 UACCAGGGCAAGAA 
                   
                   
               
               
                   
                   
                   
                 UGGCGCUGUGUCCG 
                   
                   
               
               
                   
                   
                   
                 GCGAGAACACCAAC 
                   
                   
               
               
                   
                   
                   
                 GGCAGAAGCCUGCU 
                   
                   
               
               
                   
                   
                   
                 GAACCAGAACGGCG 
                   
                   
               
               
                   
                   
                   
                 ACGGAUAUGGCGGC 
                   
                   
               
               
                   
                   
                   
                 AGCCUGACAUAUGC 
                   
                   
               
               
                   
                   
                   
                 CAUCGGCGAGGGCU 
                   
                   
               
               
                   
                   
                   
                 UUUCUGUCGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCCAUCACCACCAG 
                   
                   
               
               
                   
                   
                   
                 CAAGAGAACAGCCG 
                   
                   
               
               
                   
                   
                   
                 ACCAGAACAACGCC 
                   
                   
               
               
                   
                   
                   
                 GCCAACGCCAGACU 
                   
                   
               
               
                   
                   
                   
                 GUACGGCAACGGCG 
                   
                   
               
               
                   
                   
                   
                 AUAGAGCCACAGUG 
                   
                   
               
               
                   
                   
                   
                 UAUACCGGCGGACU 
                   
                   
               
               
                   
                   
                   
                 GAAGUACGACGCCA 
                   
                   
               
               
                   
                   
                   
                 ACAACAUCUACCUG 
                   
                   
               
               
                   
                   
                   
                 GCCGCUCAGUACAG 
                   
                   
               
               
                   
                   
                   
                 CCAGACAUACAACG 
                   
                   
               
               
                   
                   
                   
                 CCGCCAGAUUCGGC 
                   
                   
               
               
                   
                   
                   
                 ACCAGCAACGGCGC 
                   
                   
               
               
                   
                   
                   
                 AAAUCCCAGCACAA 
                   
                   
               
               
                   
                   
                   
                 GCUACGGCUUCGCC 
                   
                   
               
               
                   
                   
                   
                 AACAAGGCCCAGAA 
                   
                   
               
               
                   
                   
                   
                 CUUUGAGGUGGUGG 
                   
                   
               
               
                   
                   
                   
                 CCCAGUACCAGUUC 
                   
                   
               
               
                   
                   
                   
                 GACUUCGGACUGAG 
                   
                   
               
               
                   
                   
                   
                 GCCUAGCGUGGCCU 
                   
                   
               
               
                   
                   
                   
                 ACCUGCAGAGCAAG 
                   
                   
               
               
                   
                   
                   
                 GGCAAAGACAUCAG 
                   
                   
               
               
                   
                   
                   
                 CAACGGAUACGGCG 
                   
                   
               
               
                   
                   
                   
                 CCAGCUACGGCGAU 
                   
                   
               
               
                   
                   
                   
                 CAGGACAUCGUGAA 
                   
                   
               
               
                   
                   
                   
                 AUACGUGGACGUGG 
                   
                   
               
               
                   
                   
                   
                 GCGCCACCUAUUAC 
                   
                   
               
               
                   
                   
                   
                 UUCAACAAGAACAU 
                   
                   
               
               
                   
                   
                   
                 GAGCACCUACGUGG 
                   
                   
               
               
                   
                   
                   
                 ACUACAAGAUCAAC 
                   
                   
               
               
                   
                   
                   
                 CUGCUGGACAAGAA 
                   
                   
               
               
                   
                   
                   
                 CGACUUCACCCGCG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGGCAUCAAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAUGAUAUUGU 
                   
                   
               
               
                   
                   
                   
                 GGCCCUGGGCCUCG 
                   
                   
               
               
                   
                   
                   
                 UGUACCAGUUU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 23 
                 24 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 171 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 24, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_SseB_c 
                 MIPMSETKNELEILLE 
                 AUGAUCCCCAUGAG 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 His 
                 KAATEPAHRSAFFRT 
                 CGAGACAAAGAACG 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 LLESTVWVPGSAAEG 
                 AGCUGGAAAUCCUG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 EAIVEDSALDLQHWE 
                 CUCGAGAAGGCCGC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 KEDGTTVIPFFTSLEA 
                 CACAGAGCCUGCUC 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 LQQAVEDEQAFVVM 
                 ACAGAAGCGCUUUC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 PARTLFEMTLGETLF 
                 UUCAGAACCCUGCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LNAKLPTGKEFMPRE 
                 GGAAAGCACCGUGU 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 ISLLLAEEGSPLSTQE 
                 GGGUGCCAGGAUCU 
                   
                 UCCCCC 
               
               
                   
                   
                 VLEGGESLILSEVAEP 
                 GCUGCUGAAGGCGA 
                   
                 CAGCCC 
               
               
                   
                   
                 PSQMIDSLTTLFKTIK 
                 AGCCAUCGUGGAAG 
                   
                 CUCCUC 
               
               
                   
                   
                 PVKRAFLCAIKEHAD 
                 AUAGCGCCCUGGAU 
                   
                 CCCUUC 
               
               
                   
                   
                 AQPNLLIGIEADGEIE 
                 CUGCAGCACUGGGA 
                   
                 CUGCAC 
               
               
                   
                   
                 EIIHAAGNVATDTLP 
                 GAAAGAGGACGGAA 
                   
                 CCGUAC 
               
               
                   
                   
                 GDEPIDICQVRKGAQ 
                 CCACAGUCAUCCCA 
                   
                 CCCCGU 
               
               
                   
                   
                 GISHFITEHIAPFYERR 
                 UUCUUCACCAGCCU 
                   
                 GGUCUU 
               
               
                   
                   
                 WGGFLRDFKQNRIIH 
                 GGAAGCCCUGCAGC 
                   
                 UGAAUA 
               
               
                   
                   
                 HHHHH 
                 AGGCUGUGGAAGAU 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 GAGCAGGCCUUCGU 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 GGUCAUGCCCGCCA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 GAACACUGUUCGAG 
                   
                   
               
               
                   
                   
                   
                 AUGACCCUGGGCGA 
                   
                   
               
               
                   
                   
                   
                 GACACUGUUCCUGA 
                   
                   
               
               
                   
                   
                   
                 ACGCCAAACUGCCC 
                   
                   
               
               
                   
                   
                   
                 ACCGGCAAAGAAUU 
                   
                   
               
               
                   
                   
                   
                 CAUGCCCAGAGAGA 
                   
                   
               
               
                   
                   
                   
                 UCUCCCUGCUGCUG 
                   
                   
               
               
                   
                   
                   
                 GCCGAGGAAGGAUC 
                   
                   
               
               
                   
                   
                   
                 UCCUCUGAGCACAC 
                   
                   
               
               
                   
                   
                   
                 AAGAGGUGCUGGAA 
                   
                   
               
               
                   
                   
                   
                 GGCGGCGAGAGCCU 
                   
                   
               
               
                   
                   
                   
                 GAUUCUGUCUGAAG 
                   
                   
               
               
                   
                   
                   
                 UGGCCGAGCCUCCU 
                   
                   
               
               
                   
                   
                   
                 AGCCAGAUGAUCGA 
                   
                   
               
               
                   
                   
                   
                 CAGCCUGACCACAC 
                   
                   
               
               
                   
                   
                   
                 UGUUCAAGACCAUC 
                   
                   
               
               
                   
                   
                   
                 AAGCCCGUGAAGCG 
                   
                   
               
               
                   
                   
                   
                 GGCCUUCCUGUGCG 
                   
                   
               
               
                   
                   
                   
                 CCAUCAAAGAACAC 
                   
                   
               
               
                   
                   
                   
                 GCUGACGCCCAGCC 
                   
                   
               
               
                   
                   
                   
                 UAACCUGCUGAUCG 
                   
                   
               
               
                   
                   
                   
                 GAAUUGAGGCCGAC 
                   
                   
               
               
                   
                   
                   
                 GGCGAGAUCGAGGA 
                   
                   
               
               
                   
                   
                   
                 AAUCAUCCACGCCG 
                   
                   
               
               
                   
                   
                   
                 CUGGAAACGUGGCC 
                   
                   
               
               
                   
                   
                   
                 ACCGAUACACUGCC 
                   
                   
               
               
                   
                   
                   
                 UGGCGACGAGCCUA 
                   
                   
               
               
                   
                   
                   
                 UCGACAUCUGCCAA 
                   
                   
               
               
                   
                   
                   
                 GUUCGGAAAGGCGC 
                   
                   
               
               
                   
                   
                   
                 CCAGGGAAUCAGCC 
                   
                   
               
               
                   
                   
                   
                 ACUUCAUCACCGAA 
                   
                   
               
               
                   
                   
                   
                 CACAUUGCCCCAUU 
                   
                   
               
               
                   
                   
                   
                 CUACGAGCGGAGAU 
                   
                   
               
               
                   
                   
                   
                 GGGGCGGCUUCCUG 
                   
                   
               
               
                   
                   
                   
                 AGAGACUUCAAGCA 
                   
                   
               
               
                   
                   
                   
                 GAACCGGAUCAUCC 
                   
                   
               
               
                   
                   
                   
                 ACCACCACCAUCAC 
                   
                   
               
               
                   
                   
                   
                 CAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 25 
                 26 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 172 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 26, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_SseB 
                 MIPMSETKNELEILLE 
                 AUGAUCCCCAUGAG 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                   
                 KAATEPAHRSAFFRT 
                 CGAGACAAAGAACG 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 LLESTVWVPGSAAEG 
                 AGCUGGAAAUCCUG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 EAIVEDSALDLQHWE 
                 CUCGAGAAGGCCGC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 KEDGTTVIPFFTSLEA 
                 CACAGAGCCUGCUC 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 LQQAVEDEQAFVVM 
                 ACAGAAGCGCUUUC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 PARTLFEMTLGETLF 
                 UUCAGAACCCUGCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LNAKLPTGKEFMPRE 
                 GGAAAGCACCGUGU 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 ISLLLAEEGSPLSTQE 
                 GGGUGCCAGGAUCU 
                   
                 UCCCCC 
               
               
                   
                   
                 VLEGGESLILSEVAEP 
                 GCUGCUGAAGGCGA 
                   
                 CAGCCC 
               
               
                   
                   
                 PSQMIDSLTTLFKTIK 
                 AGCCAUCGUGGAAG 
                   
                 CUCCUC 
               
               
                   
                   
                 PVKRAFLCAIKEHAD 
                 AUAGCGCCCUGGAU 
                   
                 CCCUUC 
               
               
                   
                   
                 AQPNLLIGIEADGEIE 
                 CUGCAGCACUGGGA 
                   
                 CUGCAC 
               
               
                   
                   
                 EIIHAAGNVATDTLP 
                 GAAAGAGGACGGAA 
                   
                 CCGUAC 
               
               
                   
                   
                 GDEPIDICQVRKGAQ 
                 CCACAGUCAUCCCA 
                   
                 CCCCGU 
               
               
                   
                   
                 GISHFITEHIAPFYERR 
                 UUCUUCACCAGCCU 
                   
                 GGUCUU 
               
               
                   
                   
                 WGGFLRDFKQNRII 
                 GGAAGCCCUGCAGC 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 AGGCUGUGGAAGAU 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 GAGCAGGCCUUCGU 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 GGUCAUGCCCGCCA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 GAACACUGUUCGAG 
                   
                   
               
               
                   
                   
                   
                 AUGACCCUGGGCGA 
                   
                   
               
               
                   
                   
                   
                 GACACUGUUCCUGA 
                   
                   
               
               
                   
                   
                   
                 ACGCCAAACUGCCC 
                   
                   
               
               
                   
                   
                   
                 ACCGGCAAAGAAUU 
                   
                   
               
               
                   
                   
                   
                 CAUGCCCAGAGAGA 
                   
                   
               
               
                   
                   
                   
                 UCUCCCUGCUGCUG 
                   
                   
               
               
                   
                   
                   
                 GCCGAGGAAGGAUC 
                   
                   
               
               
                   
                   
                   
                 UCCUCUGAGCACAC 
                   
                   
               
               
                   
                   
                   
                 AAGAGGUGCUGGAA 
                   
                   
               
               
                   
                   
                   
                 GGCGGCGAGAGCCU 
                   
                   
               
               
                   
                   
                   
                 GAUUCUGUCUGAAG 
                   
                   
               
               
                   
                   
                   
                 UGGCCGAGCCUCCU 
                   
                   
               
               
                   
                   
                   
                 AGCCAGAUGAUCGA 
                   
                   
               
               
                   
                   
                   
                 CAGCCUGACCACAC 
                   
                   
               
               
                   
                   
                   
                 UGUUCAAGACCAUC 
                   
                   
               
               
                   
                   
                   
                 AAGCCCGUGAAGCG 
                   
                   
               
               
                   
                   
                   
                 GGCCUUCCUGUGCG 
                   
                   
               
               
                   
                   
                   
                 CCAUCAAAGAACAC 
                   
                   
               
               
                   
                   
                   
                 GCUGACGCCCAGCC 
                   
                   
               
               
                   
                   
                   
                 UAACCUGCUGAUCG 
                   
                   
               
               
                   
                   
                   
                 GAAUUGAGGCCGAC 
                   
                   
               
               
                   
                   
                   
                 GGCGAGAUCGAGGA 
                   
                   
               
               
                   
                   
                   
                 AAUCAUCCACGCCG 
                   
                   
               
               
                   
                   
                   
                 CUGGAAACGUGGCC 
                   
                   
               
               
                   
                   
                   
                 ACCGAUACACUGCC 
                   
                   
               
               
                   
                   
                   
                 UGGCGACGAGCCUA 
                   
                   
               
               
                   
                   
                   
                 UCGACAUCUGCCAA 
                   
                   
               
               
                   
                   
                   
                 GUUCGGAAAGGCGC 
                   
                   
               
               
                   
                   
                   
                 CCAGGGAAUCAGCC 
                   
                   
               
               
                   
                   
                   
                 ACUUCAUCACCGAA 
                   
                   
               
               
                   
                   
                   
                 CACAUUGCCCCAUU 
                   
                   
               
               
                   
                   
                   
                 CUACGAGCGGAGAU 
                   
                   
               
               
                   
                   
                   
                 GGGGCGGCUUCCUG 
                   
                   
               
               
                   
                   
                   
                 AGAGACUUCAAGCA 
                   
                   
               
               
                   
                   
                   
                 GAACCGGAUCAUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 27 
                 28 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 173 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 28, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_SseB_n 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 IgK_cHis 
                   PDTTG IPMSETKNELE 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 ILLEKAATEPAHRSAF 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 FRTLLESTVWVPGSA 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 AEGEAIVEDSALDLQ 
                   AGGC AUCCCCAUGA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 HWEKEDGTTVIPFFT 
                 GCGAGACAAAGAAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 SLEALQQAVEDEQAF 
                 GAGCUGGAAAUCCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 VVMPARTLFEMTLG 
                 GCUCGAGAAGGCCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 ETLFLNAKLPTGKEF 
                 CCACAGAGCCUGCU 
                   
                 UCCCCC 
               
               
                   
                   
                 MPREISLLLAEEGSPL 
                 CACAGAAGCGCUUU 
                   
                 CAGCCC 
               
               
                   
                   
                 STQEVLEGGESLILSE 
                 CUUCAGAACCCUGC 
                   
                 CUCCUC 
               
               
                   
                   
                 VAEPPSQMIDSLTTLF 
                 UGGAAAGCACCGUG 
                   
                 CCCUUC 
               
               
                   
                   
                 KTIKPVKRAFLCAIKE 
                 UGGGUGCCAGGAUC 
                   
                 CUGCAC 
               
               
                   
                   
                 HADAQPNLLIGIEAD 
                 UGCUGCUGAAGGCG 
                   
                 CCGUAC 
               
               
                   
                   
                 GEIEEIIHAAGNVATD 
                 AAGCCAUCGUGGAA 
                   
                 CCCCGU 
               
               
                   
                   
                 TLPGDEPIDICQVRKG 
                 GAUAGCGCCCUGGA 
                   
                 GGUCUU 
               
               
                   
                   
                 AQGISHFITEHIAPFY 
                 UCUGCAGCACUGGG 
                   
                 UGAAUA 
               
               
                   
                   
                 ERRWGGFLRDFKQN 
                 AGAAAGAGGACGGA 
                   
                 AAGUCU 
               
               
                   
                   
                 RIIHHHHHH 
                 ACCACAGUCAUCCC 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 AUUCUUCACCAGCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 UGGAAGCCCUGCAG 
                   
                   
               
               
                   
                   
                   
                 CAGGCUGUGGAAGA 
                   
                   
               
               
                   
                   
                   
                 UGAGCAGGCCUUCG 
                   
                   
               
               
                   
                   
                   
                 UGGUCAUGCCCGCC 
                   
                   
               
               
                   
                   
                   
                 AGAACACUGUUCGA 
                   
                   
               
               
                   
                   
                   
                 GAUGACCCUGGGCG 
                   
                   
               
               
                   
                   
                   
                 AGACACUGUUCCUG 
                   
                   
               
               
                   
                   
                   
                 AACGCCAAACUGCC 
                   
                   
               
               
                   
                   
                   
                 CACCGGCAAAGAAU 
                   
                   
               
               
                   
                   
                   
                 UCAUGCCCAGAGAG 
                   
                   
               
               
                   
                   
                   
                 AUCUCCCUGCUGCU 
                   
                   
               
               
                   
                   
                   
                 GGCCGAGGAAGGAU 
                   
                   
               
               
                   
                   
                   
                 CUCCUCUGAGCACA 
                   
                   
               
               
                   
                   
                   
                 CAAGAGGUGCUGGA 
                   
                   
               
               
                   
                   
                   
                 AGGCGGCGAGAGCC 
                   
                   
               
               
                   
                   
                   
                 UGAUUCUGUCUGAA 
                   
                   
               
               
                   
                   
                   
                 GUGGCCGAGCCUCC 
                   
                   
               
               
                   
                   
                   
                 UAGCCAGAUGAUCG 
                   
                   
               
               
                   
                   
                   
                 ACAGCCUGACCACA 
                   
                   
               
               
                   
                   
                   
                 CUGUUCAAGACCAU 
                   
                   
               
               
                   
                   
                   
                 CAAGCCCGUGAAGC 
                   
                   
               
               
                   
                   
                   
                 GGGCCUUCCUGUGC 
                   
                   
               
               
                   
                   
                   
                 GCCAUCAAAGAACA 
                   
                   
               
               
                   
                   
                   
                 CGCUGACGCCCAGC 
                   
                   
               
               
                   
                   
                   
                 CUAACCUGCUGAUC 
                   
                   
               
               
                   
                   
                   
                 GGAAUUGAGGCCGA 
                   
                   
               
               
                   
                   
                   
                 CGGCGAGAUCGAGG 
                   
                   
               
               
                   
                   
                   
                 AAAUCAUCCACGCC 
                   
                   
               
               
                   
                   
                   
                 GCUGGAAACGUGGC 
                   
                   
               
               
                   
                   
                   
                 CACCGAUACACUGC 
                   
                   
               
               
                   
                   
                   
                 CUGGCGACGAGCCU 
                   
                   
               
               
                   
                   
                   
                 AUCGACAUCUGCCA 
                   
                   
               
               
                   
                   
                   
                 AGUUCGGAAAGGCG 
                   
                   
               
               
                   
                   
                   
                 CCCAGGGAAUCAGC 
                   
                   
               
               
                   
                   
                   
                 CACUUCAUCACCGA 
                   
                   
               
               
                   
                   
                   
                 ACACAUUGCCCCAU 
                   
                   
               
               
                   
                   
                   
                 UCUACGAGCGGAGA 
                   
                   
               
               
                   
                   
                   
                 UGGGGCGGCUUCCU 
                   
                   
               
               
                   
                   
                   
                 GAGAGACUUCAAGC 
                   
                   
               
               
                   
                   
                   
                 AGAACCGGAUCAUC 
                   
                   
               
               
                   
                   
                   
                 CACCACCACCAUCA 
                   
                   
               
               
                   
                   
                   
                 CCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 29 
                 30 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 174 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 30, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_SseB_n 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 IgK 
                   PDTTG IPMSETKNELE 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 ILLEKAATEPAHRSAF 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 FRTLLESTVWVPGSA 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 AEGEAIVEDSALDLQ 
                   AGGC AUCCCCAUGA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 HWEKEDGTTVIPFFT 
                 GCGAGACAAAGAAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 SLEALQQAVEDEQAF 
                 GAGCUGGAAAUCCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 VVMPARTLFEMTLG 
                 GCUCGAGAAGGCCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 ETLFLNAKLPTGKEF 
                 CCACAGAGCCUGCU 
                   
                 UCCCCC 
               
               
                   
                   
                 MPREISLLLAEEGSPL 
                 CACAGAAGCGCUUU 
                   
                 CAGCCC 
               
               
                   
                   
                 STQEVLEGGESLILSE 
                 CUUCAGAACCCUGC 
                   
                 CUCCUC 
               
               
                   
                   
                 VAEPPSQMIDSLTTLF 
                 UGGAAAGCACCGUG 
                   
                 CCCUUC 
               
               
                   
                   
                 KTIKPVKRAFLCAIKE 
                 UGGGUGCCAGGAUC 
                   
                 CUGCAC 
               
               
                   
                   
                 HADAQPNLLIGIEAD 
                 UGCUGCUGAAGGCG 
                   
                 CCGUAC 
               
               
                   
                   
                 GEIEEIIHAAGNVATD 
                 AAGCCAUCGUGGAA 
                   
                 CCCCGU 
               
               
                   
                   
                 TLPGDEPIDICQVRKG 
                 GAUAGCGCCCUGGA 
                   
                 GGUCUU 
               
               
                   
                   
                 AQGISHFITEHIAPFY 
                 UCUGCAGCACUGGG 
                   
                 UGAAUA 
               
               
                   
                   
                 ERRWGGFLRDFKQN 
                 AGAAAGAGGACGGA 
                   
                 AAGUCU 
               
               
                   
                   
                 RII 
                 ACCACAGUCAUCCC 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 AUUCUUCACCAGCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 UGGAAGCCCUGCAG 
                   
                   
               
               
                   
                   
                   
                 CAGGCUGUGGAAGA 
                   
                   
               
               
                   
                   
                   
                 UGAGCAGGCCUUCG 
                   
                   
               
               
                   
                   
                   
                 UGGUCAUGCCCGCC 
                   
                   
               
               
                   
                   
                   
                 AGAACACUGUUCGA 
                   
                   
               
               
                   
                   
                   
                 GAUGACCCUGGGCG 
                   
                   
               
               
                   
                   
                   
                 AGACACUGUUCCUG 
                   
                   
               
               
                   
                   
                   
                 AACGCCAAACUGCC 
                   
                   
               
               
                   
                   
                   
                 CACCGGCAAAGAAU 
                   
                   
               
               
                   
                   
                   
                 UCAUGCCCAGAGAG 
                   
                   
               
               
                   
                   
                   
                 AUCUCCCUGCUGCU 
                   
                   
               
               
                   
                   
                   
                 GGCCGAGGAAGGAU 
                   
                   
               
               
                   
                   
                   
                 CUCCUCUGAGCACA 
                   
                   
               
               
                   
                   
                   
                 CAAGAGGUGCUGGA 
                   
                   
               
               
                   
                   
                   
                 AGGCGGCGAGAGCC 
                   
                   
               
               
                   
                   
                   
                 UGAUUCUGUCUGAA 
                   
                   
               
               
                   
                   
                   
                 GUGGCCGAGCCUCC 
                   
                   
               
               
                   
                   
                   
                 UAGCCAGAUGAUCG 
                   
                   
               
               
                   
                   
                   
                 ACAGCCUGACCACA 
                   
                   
               
               
                   
                   
                   
                 CUGUUCAAGACCAU 
                   
                   
               
               
                   
                   
                   
                 CAAGCCCGUGAAGC 
                   
                   
               
               
                   
                   
                   
                 GGGCCUUCCUGUGC 
                   
                   
               
               
                   
                   
                   
                 GCCAUCAAAGAACA 
                   
                   
               
               
                   
                   
                   
                 CGCUGACGCCCAGC 
                   
                   
               
               
                   
                   
                   
                 CUAACCUGCUGAUC 
                   
                   
               
               
                   
                   
                   
                 GGAAUUGAGGCCGA 
                   
                   
               
               
                   
                   
                   
                 CGGCGAGAUCGAGG 
                   
                   
               
               
                   
                   
                   
                 AAAUCAUCCACGCC 
                   
                   
               
               
                   
                   
                   
                 GCUGGAAACGUGGC 
                   
                   
               
               
                   
                   
                   
                 CACCGAUACACUGC 
                   
                   
               
               
                   
                   
                   
                 CUGGCGACGAGCCU 
                   
                   
               
               
                   
                   
                   
                 AUCGACAUCUGCCA 
                   
                   
               
               
                   
                   
                   
                 AGUUCGGAAAGGCG 
                   
                   
               
               
                   
                   
                   
                 CCCAGGGAAUCAGC 
                   
                   
               
               
                   
                   
                   
                 CACUUCAUCACCGA 
                   
                   
               
               
                   
                   
                   
                 ACACAUUGCCCCAU 
                   
                   
               
               
                   
                   
                   
                 UCUACGAGCGGAGA 
                   
                   
               
               
                   
                   
                   
                 UGGGGCGGCUUCCU 
                   
                   
               
               
                   
                   
                   
                 GAGAGACUUCAAGC 
                   
                   
               
               
                   
                   
                   
                 AGAACCGGAUCAUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 31 
                 32 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 175 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 32, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_FliC_c 
                 MAQVINTNSLSLLTQ 
                 AUGGCCCAAGUGAU 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 His 
                 NNLNKSQSALGTAIE 
                 CAACACCAACAGCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 RLSSGLRINSAKDDA 
                 UGAGCCUGCUGACC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 AGQAIANRFTANIKG 
                 CAGAACAACCUGAA 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 LTQASRNANDGISIA 
                 CAAGAGCCAGAGCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 QTTEGALNEINNNLQ 
                 CCCUGGGCACAGCC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 RVRELAVQSANGTNS 
                 AUCGAAAGACUGUC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 QSDLDSIQAEITQRLN 
                 UAGCGGCCUGCGGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 EIDRVSGQTQFNGVK 
                 UCAACAGCGCCAAA 
                   
                 UCCCCC 
               
               
                   
                   
                 VLAQDNTLTIQVGAN 
                 GAUGAUGCUGCCGG 
                   
                 CAGCCC 
               
               
                   
                   
                 DGETIDIDLKEISSKT 
                 ACAGGCCAUUGCCA 
                   
                 CUCCUC 
               
               
                   
                   
                 LGLDKLNVQDAYTP 
                 ACAGAUUCACCGCC 
                   
                 CCCUUC 
               
               
                   
                   
                 KETAVTVDKTTYKN 
                 AACAUCAAGGGCCU 
                   
                 CUGCAC 
               
               
                   
                   
                 GTDPITAQSNTDIQTA 
                 GACACAGGCCAGCA 
                   
                 CCGUAC 
               
               
                   
                   
                 IGGGATGVTGADIKF 
                 GAAACGCCAACGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 KDGQYYLDVKGGAS 
                 GGCAUCUCUAUCGC 
                   
                 GGUCUU 
               
               
                   
                   
                 AGVYKATYDETTKK 
                 CCAGACAACAGAAG 
                   
                 UGAAUA 
               
               
                   
                   
                 VNIDTTDKTPLATAE 
                 GCGCCCUGAACGAG 
                   
                 AAGUCU 
               
               
                   
                   
                 ATAIRGTATITHNQIA 
                 AUCAACAACAACCU 
                   
                 GAGUGG 
               
               
                   
                   
                 EVTKEGVDTTTVAA 
                 GCAGAGAGUGCGCG 
                   
                 GCGGC 
               
               
                   
                   
                 QLAAAGVTGADKDN 
                 AGCUGGCCGUGCAA 
                   
                   
               
               
                   
                   
                 TSLVKLSFEDKNGKV 
                 UCUGCCAAUGGCAC 
                   
                   
               
               
                   
                   
                 IDGGYAVKMGDDFY 
                 AAACAGCCAGUCCG 
                   
                   
               
               
                   
                   
                 AATYDEKTGAITAKT 
                 ACCUGGAUUCCAUC 
                   
                   
               
               
                   
                   
                 TTYTDGTGVAQTGA 
                 CAGGCCGAGAUCAC 
                   
                   
               
               
                   
                   
                 VKFGGANGKSEVVT 
                 CCAGCGGCUGAAUG 
                   
                   
               
               
                   
                   
                 ATDGKTYLASDLDK 
                 AGAUCGACAGAGUG 
                   
                   
               
               
                   
                   
                 HNFRTGGELKEVNTD 
                 UCCGGCCAGACACA 
                   
                   
               
               
                   
                   
                 KTENPLQKIDAALAQ 
                 GUUCAACGGCGUGA 
                   
                   
               
               
                   
                   
                 VDTLRSDLGAVQNRF 
                 AAGUGCUGGCCCAG 
                   
                   
               
               
                   
                   
                 NSAITNLGNTVNNLS 
                 GACAACACCCUGAC 
                   
                   
               
               
                   
                   
                 SARSRIEDSDYATEVS 
                 CAUCCAAGUGGGAG 
                   
                   
               
               
                   
                   
                 NMSRAQILQQAGTSV 
                 CCAACGAUGGCGAG 
                   
                   
               
               
                   
                   
                 LAQANQVPQNVLSLL 
                 ACAAUCGACAUCGA 
                   
                   
               
               
                   
                   
                 RHHHHHH 
                 CCUGAAAGAGAUCU 
                   
                   
               
               
                   
                   
                   
                 CCAGCAAGACCCUG 
                   
                   
               
               
                   
                   
                   
                 GGCCUCGACAAGCU 
                   
                   
               
               
                   
                   
                   
                 GAACGUGCAGGAUG 
                   
                   
               
               
                   
                   
                   
                 CCUACACACCCAAA 
                   
                   
               
               
                   
                   
                   
                 GAAACCGCCGUGAC 
                   
                   
               
               
                   
                   
                   
                 CGUGGACAAGACCA 
                   
                   
               
               
                   
                   
                   
                 CCUACAAGAACGGC 
                   
                   
               
               
                   
                   
                   
                 ACAGACCCCAUCAC 
                   
                   
               
               
                   
                   
                   
                 AGCCCAGAGCAACA 
                   
                   
               
               
                   
                   
                   
                 CCGAUAUCCAGACC 
                   
                   
               
               
                   
                   
                   
                 GCCAUUGGAGGCGG 
                   
                   
               
               
                   
                   
                   
                 AGCUACAGGUGUUA 
                   
                   
               
               
                   
                   
                   
                 CAGGCGCCGACAUC 
                   
                   
               
               
                   
                   
                   
                 AAGUUCAAGGACGG 
                   
                   
               
               
                   
                   
                   
                 CCAGUACUACCUGG 
                   
                   
               
               
                   
                   
                   
                 ACGUGAAAGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCAUCUGCCGGCGU 
                   
                   
               
               
                   
                   
                   
                 GUACAAGGCCACAU 
                   
                   
               
               
                   
                   
                   
                 ACGACGAAACCACC 
                   
                   
               
               
                   
                   
                   
                 AAGAAAGUGAACAU 
                   
                   
               
               
                   
                   
                   
                 CGACACCACCGACA 
                   
                   
               
               
                   
                   
                   
                 AGACCCCUCUGGCC 
                   
                   
               
               
                   
                   
                   
                 ACAGCUGAAGCCAC 
                   
                   
               
               
                   
                   
                   
                 AGCCAUUAGAGGCA 
                   
                   
               
               
                   
                   
                   
                 CCGCCACAAUCACC 
                   
                   
               
               
                   
                   
                   
                 CACAACCAGAUCGC 
                   
                   
               
               
                   
                   
                   
                 CGAAGUGACCAAAG 
                   
                   
               
               
                   
                   
                   
                 AAGGCGUGGACACC 
                   
                   
               
               
                   
                   
                   
                 ACAACCGUGGCUGC 
                   
                   
               
               
                   
                   
                   
                 UCAACUUGCUGCUG 
                   
                   
               
               
                   
                   
                   
                 CUGGCGUUACCGGC 
                   
                   
               
               
                   
                   
                   
                 GCUGACAAGGAUAA 
                   
                   
               
               
                   
                   
                   
                 UACCAGCCUGGUCA 
                   
                   
               
               
                   
                   
                   
                 AGCUGAGCUUCGAG 
                   
                   
               
               
                   
                   
                   
                 GACAAGAAUGGCAA 
                   
                   
               
               
                   
                   
                   
                 AGUGAUCGACGGCG 
                   
                   
               
               
                   
                   
                   
                 GCUACGCCGUGAAG 
                   
                   
               
               
                   
                   
                   
                 AUGGGCGACGAUUU 
                   
                   
               
               
                   
                   
                   
                 CUACGCCGCCACCU 
                   
                   
               
               
                   
                   
                   
                 ACGAUGAGAAGACC 
                   
                   
               
               
                   
                   
                   
                 GGCGCCAUUACCGC 
                   
                   
               
               
                   
                   
                   
                 CAAGACCACAACCU 
                   
                   
               
               
                   
                   
                   
                 ACACAGAUGGCACA 
                   
                   
               
               
                   
                   
                   
                 GGCGUGGCACAGAC 
                   
                   
               
               
                   
                   
                   
                 AGGGGCCGUGAAAU 
                   
                   
               
               
                   
                   
                   
                 UUGGAGGCGCCAAC 
                   
                   
               
               
                   
                   
                   
                 GGCAAGAGCGAGGU 
                   
                   
               
               
                   
                   
                   
                 CGUGACAGCUACCG 
                   
                   
               
               
                   
                   
                   
                 ACGGCAAGACAUAC 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAGCGAUCU 
                   
                   
               
               
                   
                   
                   
                 GGACAAGCACAACU 
                   
                   
               
               
                   
                   
                   
                 UCAGAACAGGCGGC 
                   
                   
               
               
                   
                   
                   
                 GAGCUGAAAGAAGU 
                   
                   
               
               
                   
                   
                   
                 GAACACAGACAAGA 
                   
                   
               
               
                   
                   
                   
                 CCGAGAAUCCGCUG 
                   
                   
               
               
                   
                   
                   
                 CAGAAGAUCGACGC 
                   
                   
               
               
                   
                   
                   
                 UGCUCUGGCACAAG 
                   
                   
               
               
                   
                   
                   
                 UGGACACCCUGAGA 
                   
                   
               
               
                   
                   
                   
                 AGUGAUCUGGGCGC 
                   
                   
               
               
                   
                   
                   
                 CGUGCAGAACAGGU 
                   
                   
               
               
                   
                   
                   
                 UCAACUCCGCCAUC 
                   
                   
               
               
                   
                   
                   
                 ACCAACCUGGGCAA 
                   
                   
               
               
                   
                   
                   
                 CACCGUGAACAAUC 
                   
                   
               
               
                   
                   
                   
                 UGAGCAGCGCCAGA 
                   
                   
               
               
                   
                   
                   
                 AGCCGGAUCGAGGA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAUUAUGCCA 
                   
                   
               
               
                   
                   
                   
                 CCGAGGUGUCCAAC 
                   
                   
               
               
                   
                   
                   
                 AUGAGCAGAGCCCA 
                   
                   
               
               
                   
                   
                   
                 GAUUCUGCAGCAGG 
                   
                   
               
               
                   
                   
                   
                 CCGGCACAUCUGUU 
                   
                   
               
               
                   
                   
                   
                 CUGGCUCAGGCAAA 
                   
                   
               
               
                   
                   
                   
                 UCAGGUGCCCCAGA 
                   
                   
               
               
                   
                   
                   
                 ACGUGCUGUCCCUG 
                   
                   
               
               
                   
                   
                   
                 CUGAGACACCACCA 
                   
                   
               
               
                   
                   
                   
                 CCAUCACCAU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 33 
                 34 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 176 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 34, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_FliC 
                 MAQVINTNSLSLLTQ 
                 AUGGCCCAAGUGAU 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                   
                 NNLNKSQSALGTAIE 
                 CAACACCAACAGCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 RLSSGLRINSAKDDA 
                 UGAGCCUGCUGACC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 AGQAIANRFTANIKG 
                 CAGAACAACCUGAA 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 LTQASRNANDGISIA 
                 CAAGAGCCAGAGCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 QTTEGALNEINNNLQ 
                 CCCUGGGCACAGCC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 RVRELAVQSANGTNS 
                 AUCGAAAGACUGUC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 QSDLDSIQAEITQRLN 
                 UAGCGGCCUGCGGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 EIDRVSGQTQFNGVK 
                 UCAACAGCGCCAAA 
                   
                 UCCCCC 
               
               
                   
                   
                 VLAQDNTLTIQVGAN 
                 GAUGAUGCUGCCGG 
                   
                 CAGCCC 
               
               
                   
                   
                 DGETIDIDLKEISSKT 
                 ACAGGCCAUUGCCA 
                   
                 CUCCUC 
               
               
                   
                   
                 LGLDKLNVQDAYTP 
                 ACAGAUUCACCGCC 
                   
                 CCCUUC 
               
               
                   
                   
                 KETAVTVDKTTYKN 
                 AACAUCAAGGGCCU 
                   
                 CUGCAC 
               
               
                   
                   
                 GTDPITAQSNTDIQTA 
                 GACACAGGCCAGCA 
                   
                 CCGUAC 
               
               
                   
                   
                 IGGGATGVTGADIKF 
                 GAAACGCCAACGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 KDGQYYLDVKGGAS 
                 GGCAUCUCUAUCGC 
                   
                 GGUCUU 
               
               
                   
                   
                 AGVYKATYDETTKK 
                 CCAGACAACAGAAG 
                   
                 UGAAUA 
               
               
                   
                   
                 VNIDTTDKTPLATAE 
                 GCGCCCUGAACGAG 
                   
                 AAGUCU 
               
               
                   
                   
                 ATAIRGTATITHNQIA 
                 AUCAACAACAACCU 
                   
                 GAGUGG 
               
               
                   
                   
                 EVTKEGVDTTTVAA 
                 GCAGAGAGUGCGCG 
                   
                 GCGGC 
               
               
                   
                   
                 QLAAAGVTGADKDN 
                 AGCUGGCCGUGCAA 
                   
                   
               
               
                   
                   
                 TSLVKLSFEDKNGKV 
                 UCUGCCAAUGGCAC 
                   
                   
               
               
                   
                   
                 IDGGYAVKMGDDFY 
                 AAACAGCCAGUCCG 
                   
                   
               
               
                   
                   
                 AATYDEKTGAITAKT 
                 ACCUGGAUUCCAUC 
                   
                   
               
               
                   
                   
                 TTYTDGTGVAQTGA 
                 CAGGCCGAGAUCAC 
                   
                   
               
               
                   
                   
                 VKFGGANGKSEVVT 
                 CCAGCGGCUGAAUG 
                   
                   
               
               
                   
                   
                 ATDGKTYLASDLDK 
                 AGAUCGACAGAGUG 
                   
                   
               
               
                   
                   
                 HNFRTGGELKEVNTD 
                 UCCGGCCAGACACA 
                   
                   
               
               
                   
                   
                 KTENPLQKIDAALAQ 
                 GUUCAACGGCGUGA 
                   
                   
               
               
                   
                   
                 VDTLRSDLGAVQNRF 
                 AAGUGCUGGCCCAG 
                   
                   
               
               
                   
                   
                 NSAITNLGNTVNNLS 
                 GACAACACCCUGAC 
                   
                   
               
               
                   
                   
                 SARSRIEDSDYATEVS 
                 CAUCCAAGUGGGAG 
                   
                   
               
               
                   
                   
                 NMSRAQILQQAGTSV 
                 CCAACGAUGGCGAG 
                   
                   
               
               
                   
                   
                 LAQANQVPQNVLSLL 
                 ACAAUCGACAUCGA 
                   
                   
               
               
                   
                   
                 R 
                 CCUGAAAGAGAUCU 
                   
                   
               
               
                   
                   
                   
                 CCAGCAAGACCCUG 
                   
                   
               
               
                   
                   
                   
                 GGCCUCGACAAGCU 
                   
                   
               
               
                   
                   
                   
                 GAACGUGCAGGAUG 
                   
                   
               
               
                   
                   
                   
                 CCUACACACCCAAA 
                   
                   
               
               
                   
                   
                   
                 GAAACCGCCGUGAC 
                   
                   
               
               
                   
                   
                   
                 CGUGGACAAGACCA 
                   
                   
               
               
                   
                   
                   
                 CCUACAAGAACGGC 
                   
                   
               
               
                   
                   
                   
                 ACAGACCCCAUCAC 
                   
                   
               
               
                   
                   
                   
                 AGCCCAGAGCAACA 
                   
                   
               
               
                   
                   
                   
                 CCGAUAUCCAGACC 
                   
                   
               
               
                   
                   
                   
                 GCCAUUGGAGGCGG 
                   
                   
               
               
                   
                   
                   
                 AGCUACAGGUGUUA 
                   
                   
               
               
                   
                   
                   
                 CAGGCGCCGACAUC 
                   
                   
               
               
                   
                   
                   
                 AAGUUCAAGGACGG 
                   
                   
               
               
                   
                   
                   
                 CCAGUACUACCUGG 
                   
                   
               
               
                   
                   
                   
                 ACGUGAAAGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCAUCUGCCGGCGU 
                   
                   
               
               
                   
                   
                   
                 GUACAAGGCCACAU 
                   
                   
               
               
                   
                   
                   
                 ACGACGAAACCACC 
                   
                   
               
               
                   
                   
                   
                 AAGAAAGUGAACAU 
                   
                   
               
               
                   
                   
                   
                 CGACACCACCGACA 
                   
                   
               
               
                   
                   
                   
                 AGACCCCUCUGGCC 
                   
                   
               
               
                   
                   
                   
                 ACAGCUGAAGCCAC 
                   
                   
               
               
                   
                   
                   
                 AGCCAUUAGAGGCA 
                   
                   
               
               
                   
                   
                   
                 CCGCCACAAUCACC 
                   
                   
               
               
                   
                   
                   
                 CACAACCAGAUCGC 
                   
                   
               
               
                   
                   
                   
                 CGAAGUGACCAAAG 
                   
                   
               
               
                   
                   
                   
                 AAGGCGUGGACACC 
                   
                   
               
               
                   
                   
                   
                 ACAACCGUGGCUGC 
                   
                   
               
               
                   
                   
                   
                 UCAACUUGCUGCUG 
                   
                   
               
               
                   
                   
                   
                 CUGGCGUUACCGGC 
                   
                   
               
               
                   
                   
                   
                 GCUGACAAGGAUAA 
                   
                   
               
               
                   
                   
                   
                 UACCAGCCUGGUCA 
                   
                   
               
               
                   
                   
                   
                 AGCUGAGCUUCGAG 
                   
                   
               
               
                   
                   
                   
                 GACAAGAAUGGCAA 
                   
                   
               
               
                   
                   
                   
                 AGUGAUCGACGGCG 
                   
                   
               
               
                   
                   
                   
                 GCUACGCCGUGAAG 
                   
                   
               
               
                   
                   
                   
                 AUGGGCGACGAUUU 
                   
                   
               
               
                   
                   
                   
                 CUACGCCGCCACCU 
                   
                   
               
               
                   
                   
                   
                 ACGAUGAGAAGACC 
                   
                   
               
               
                   
                   
                   
                 GGCGCCAUUACCGC 
                   
                   
               
               
                   
                   
                   
                 CAAGACCACAACCU 
                   
                   
               
               
                   
                   
                   
                 ACACAGAUGGCACA 
                   
                   
               
               
                   
                   
                   
                 GGCGUGGCACAGAC 
                   
                   
               
               
                   
                   
                   
                 AGGGGCCGUGAAAU 
                   
                   
               
               
                   
                   
                   
                 UUGGAGGCGCCAAC 
                   
                   
               
               
                   
                   
                   
                 GGCAAGAGCGAGGU 
                   
                   
               
               
                   
                   
                   
                 CGUGACAGCUACCG 
                   
                   
               
               
                   
                   
                   
                 ACGGCAAGACAUAC 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAGCGAUCU 
                   
                   
               
               
                   
                   
                   
                 GGACAAGCACAACU 
                   
                   
               
               
                   
                   
                   
                 UCAGAACAGGCGGC 
                   
                   
               
               
                   
                   
                   
                 GAGCUGAAAGAAGU 
                   
                   
               
               
                   
                   
                   
                 GAACACAGACAAGA 
                   
                   
               
               
                   
                   
                   
                 CCGAGAAUCCGCUG 
                   
                   
               
               
                   
                   
                   
                 CAGAAGAUCGACGC 
                   
                   
               
               
                   
                   
                   
                 UGCUCUGGCACAAG 
                   
                   
               
               
                   
                   
                   
                 UGGACACCCUGAGA 
                   
                   
               
               
                   
                   
                   
                 AGUGAUCUGGGCGC 
                   
                   
               
               
                   
                   
                   
                 CGUGCAGAACAGGU 
                   
                   
               
               
                   
                   
                   
                 UCAACUCCGCCAUC 
                   
                   
               
               
                   
                   
                   
                 ACCAACCUGGGCAA 
                   
                   
               
               
                   
                   
                   
                 CACCGUGAACAAUC 
                   
                   
               
               
                   
                   
                   
                 UGAGCAGCGCCAGA 
                   
                   
               
               
                   
                   
                   
                 AGCCGGAUCGAGGA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAUUAUGCCA 
                   
                   
               
               
                   
                   
                   
                 CCGAGGUGUCCAAC 
                   
                   
               
               
                   
                   
                   
                 AUGAGCAGAGCCCA 
                   
                   
               
               
                   
                   
                   
                 GAUUCUGCAGCAGG 
                   
                   
               
               
                   
                   
                   
                 CCGGCACAUCUGUU 
                   
                   
               
               
                   
                   
                   
                 CUGGCUCAGGCAAA 
                   
                   
               
               
                   
                   
                   
                 UCAGGUGCCCCAGA 
                   
                   
               
               
                   
                   
                   
                 ACGUGCUGUCCCUG 
                   
                   
               
               
                   
                   
                   
                 CUGAGA 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 35 
                 36 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 177 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 36, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_FliC_nI 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 gK_cHis 
                   PDTTG AQVINTNSLS 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 LLTQNNLNKSQSALG 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 TAIERLSSGLRINSAK 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 DDAAGQAIANRFTA 
                   AGGC GCCCAAGUGA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NIKGLTQASRNANDG 
                 UCAACACCAACAGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 ISIAQTTEGALNEINN 
                 CUGAGCCUGCUGAC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 NLQRVRELAVQSAN 
                 CCAGAACAACCUGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 GTNSQSDLDSIQAEIT 
                 ACAAGAGCCAGAGC 
                   
                 UCCCCC 
               
               
                   
                   
                 QRLNEIDRVSGQTQF 
                 GCCCUGGGCACAGC 
                   
                 CAGCCC 
               
               
                   
                   
                 NGVKVLAQDNTLTIQ 
                 CAUCGAAAGACUGU 
                   
                 CUCCUC 
               
               
                   
                   
                 VGANDGETIDIDLKEI 
                 CUAGCGGCCUGCGG 
                   
                 CCCUUC 
               
               
                   
                   
                 SSKTLGLDKLNVQDA 
                 AUCAACAGCGCCAA 
                   
                 CUGCAC 
               
               
                   
                   
                 YTPKETAVTVDKTTY 
                 AGAUGAUGCUGCCG 
                   
                 CCGUAC 
               
               
                   
                   
                 KNGTDPITAQSNTDI 
                 GACAGGCCAUUGCC 
                   
                 CCCCGU 
               
               
                   
                   
                 QTAIGGGATGVTGA 
                 AACAGAUUCACCGC 
                   
                 GGUCUU 
               
               
                   
                   
                 DIKFKDGQYYLDVK 
                 CAACAUCAAGGGCC 
                   
                 UGAAUA 
               
               
                   
                   
                 GGASAGVYKATYDE 
                 UGACACAGGCCAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 TTKKVNIDTTDKTPL 
                 AGAAACGCCAACGA 
                   
                 GAGUGG 
               
               
                   
                   
                 ATAEATAIRGTATITH 
                 CGGCAUCUCUAUCG 
                   
                 GCGGC 
               
               
                   
                   
                 NQIAEVTKEGVDTTT 
                 CCCAGACAACAGAA 
                   
                   
               
               
                   
                   
                 VAAQLAAAGVTGAD 
                 GGCGCCCUGAACGA 
                   
                   
               
               
                   
                   
                 KDNTSLVKLSFEDKN 
                 GAUCAACAACAACC 
                   
                   
               
               
                   
                   
                 GKVIDGGYAVKMGD 
                 UGCAGAGAGUGCGC 
                   
                   
               
               
                   
                   
                 DFYAATYDEKTGAIT 
                 GAGCUGGCCGUGCA 
                   
                   
               
               
                   
                   
                 AKTTTYTDGTGVAQ 
                 AUCUGCCAAUGGCA 
                   
                   
               
               
                   
                   
                 TGAVKFGGANGKSE 
                 CAAACAGCCAGUCC 
                   
                   
               
               
                   
                   
                 VVTATDGKTYLASD 
                 GACCUGGAUUCCAU 
                   
                   
               
               
                   
                   
                 LDKHNFRTGGELKEV 
                 CCAGGCCGAGAUCA 
                   
                   
               
               
                   
                   
                 NTDKTENPLQKIDAA 
                 CCCAGCGGCUGAAU 
                   
                   
               
               
                   
                   
                 LAQVDTLRSDLGAV 
                 GAGAUCGACAGAGU 
                   
                   
               
               
                   
                   
                 QNRFNSAITNLGNTV 
                 GUCCGGCCAGACAC 
                   
                   
               
               
                   
                   
                 NNLSSARSRIEDSDY 
                 AGUUCAACGGCGUG 
                   
                   
               
               
                   
                   
                 ATEVSNMSRAQILQQ 
                 AAAGUGCUGGCCCA 
                   
                   
               
               
                   
                   
                 AGTSVLAQANQVPQ 
                 GGACAACACCCUGA 
                   
                   
               
               
                   
                   
                 NVLSLLRHHHHHH 
                 CCAUCCAAGUGGGA 
                   
                   
               
               
                   
                   
                   
                 GCCAACGAUGGCGA 
                   
                   
               
               
                   
                   
                   
                 GACAAUCGACAUCG 
                   
                   
               
               
                   
                   
                   
                 ACCUGAAAGAGAUC 
                   
                   
               
               
                   
                   
                   
                 UCCAGCAAGACCCU 
                   
                   
               
               
                   
                   
                   
                 GGGCCUCGACAAGC 
                   
                   
               
               
                   
                   
                   
                 UGAACGUGCAGGAU 
                   
                   
               
               
                   
                   
                   
                 GCCUACACACCCAA 
                   
                   
               
               
                   
                   
                   
                 AGAAACCGCCGUGA 
                   
                   
               
               
                   
                   
                   
                 CCGUGGACAAGACC 
                   
                   
               
               
                   
                   
                   
                 ACCUACAAGAACGG 
                   
                   
               
               
                   
                   
                   
                 CACAGACCCCAUCA 
                   
                   
               
               
                   
                   
                   
                 CAGCCCAGAGCAAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAUAUCCAGAC 
                   
                   
               
               
                   
                   
                   
                 CGCCAUUGGAGGCG 
                   
                   
               
               
                   
                   
                   
                 GAGCUACAGGUGUU 
                   
                   
               
               
                   
                   
                   
                 ACAGGCGCCGACAU 
                   
                   
               
               
                   
                   
                   
                 CAAGUUCAAGGACG 
                   
                   
               
               
                   
                   
                   
                 GCCAGUACUACCUG 
                   
                   
               
               
                   
                   
                   
                 GACGUGAAAGGCGG 
                   
                   
               
               
                   
                   
                   
                 AGCAUCUGCCGGCG 
                   
                   
               
               
                   
                   
                   
                 UGUACAAGGCCACA 
                   
                   
               
               
                   
                   
                   
                 UACGACGAAACCAC 
                   
                   
               
               
                   
                   
                   
                 CAAGAAAGUGAACA 
                   
                   
               
               
                   
                   
                   
                 UCGACACCACCGAC 
                   
                   
               
               
                   
                   
                   
                 AAGACCCCUCUGGC 
                   
                   
               
               
                   
                   
                   
                 CACAGCUGAAGCCA 
                   
                   
               
               
                   
                   
                   
                 CAGCCAUUAGAGGC 
                   
                   
               
               
                   
                   
                   
                 ACCGCCACAAUCAC 
                   
                   
               
               
                   
                   
                   
                 CCACAACCAGAUCG 
                   
                   
               
               
                   
                   
                   
                 CCGAAGUGACCAAA 
                   
                   
               
               
                   
                   
                   
                 GAAGGCGUGGACAC 
                   
                   
               
               
                   
                   
                   
                 CACAACCGUGGCUG 
                   
                   
               
               
                   
                   
                   
                 CUCAACUUGCUGCU 
                   
                   
               
               
                   
                   
                   
                 GCUGGCGUUACCGG 
                   
                   
               
               
                   
                   
                   
                 CGCUGACAAGGAUA 
                   
                   
               
               
                   
                   
                   
                 AUACCAGCCUGGUC 
                   
                   
               
               
                   
                   
                   
                 AAGCUGAGCUUCGA 
                   
                   
               
               
                   
                   
                   
                 GGACAAGAAUGGCA 
                   
                   
               
               
                   
                   
                   
                 AAGUGAUCGACGGC 
                   
                   
               
               
                   
                   
                   
                 GGCUACGCCGUGAA 
                   
                   
               
               
                   
                   
                   
                 GAUGGGCGACGAUU 
                   
                   
               
               
                   
                   
                   
                 UCUACGCCGCCACC 
                   
                   
               
               
                   
                   
                   
                 UACGAUGAGAAGAC 
                   
                   
               
               
                   
                   
                   
                 CGGCGCCAUUACCG 
                   
                   
               
               
                   
                   
                   
                 CCAAGACCACAACC 
                   
                   
               
               
                   
                   
                   
                 UACACAGAUGGCAC 
                   
                   
               
               
                   
                   
                   
                 AGGCGUGGCACAGA 
                   
                   
               
               
                   
                   
                   
                 CAGGGGCCGUGAAA 
                   
                   
               
               
                   
                   
                   
                 UUUGGAGGCGCCAA 
                   
                   
               
               
                   
                   
                   
                 CGGCAAGAGCGAGG 
                   
                   
               
               
                   
                   
                   
                 UCGUGACAGCUACC 
                   
                   
               
               
                   
                   
                   
                 GACGGCAAGACAUA 
                   
                   
               
               
                   
                   
                   
                 CCUGGCCAGCGAUC 
                   
                   
               
               
                   
                   
                   
                 UGGACAAGCACAAC 
                   
                   
               
               
                   
                   
                   
                 UUCAGAACAGGCGG 
                   
                   
               
               
                   
                   
                   
                 CGAGCUGAAAGAAG 
                   
                   
               
               
                   
                   
                   
                 UGAACACAGACAAG 
                   
                   
               
               
                   
                   
                   
                 ACCGAGAAUCCGCU 
                   
                   
               
               
                   
                   
                   
                 GCAGAAGAUCGACG 
                   
                   
               
               
                   
                   
                   
                 CUGCUCUGGCACAA 
                   
                   
               
               
                   
                   
                   
                 GUGGACACCCUGAG 
                   
                   
               
               
                   
                   
                   
                 AAGUGAUCUGGGCG 
                   
                   
               
               
                   
                   
                   
                 CCGUGCAGAACAGG 
                   
                   
               
               
                   
                   
                   
                 UUCAACUCCGCCAU 
                   
                   
               
               
                   
                   
                   
                 CACCAACCUGGGCA 
                   
                   
               
               
                   
                   
                   
                 ACACCGUGAACAAU 
                   
                   
               
               
                   
                   
                   
                 CUGAGCAGCGCCAG 
                   
                   
               
               
                   
                   
                   
                 AAGCCGGAUCGAGG 
                   
                   
               
               
                   
                   
                   
                 ACAGCGAUUAUGCC 
                   
                   
               
               
                   
                   
                   
                 ACCGAGGUGUCCAA 
                   
                   
               
               
                   
                   
                   
                 CAUGAGCAGAGCCC 
                   
                   
               
               
                   
                   
                   
                 AGAUUCUGCAGCAG 
                   
                   
               
               
                   
                   
                   
                 GCCGGCACAUCUGU 
                   
                   
               
               
                   
                   
                   
                 UCUGGCUCAGGCAA 
                   
                   
               
               
                   
                   
                   
                 AUCAGGUGCCCCAG 
                   
                   
               
               
                   
                   
                   
                 AACGUGCUGUCCCU 
                   
                   
               
               
                   
                   
                   
                 GCUGAGACACCACC 
                   
                   
               
               
                   
                   
                   
                 ACCAUCACCAU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 37 
                 38 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 178 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 38, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_FliC_nI 
                 
                   METPAQLLFLLLLWL 
                 
                 
                   AUGGAAACCCCUGC 
                 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 gK 
                   PDTTG AQVINTNSLS 
                 
                   UCAGCUGCUGUUCC 
                 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 LLTQNNLNKSQSALG 
                 
                   UGCUGCUGCUGUGG 
                 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 TAIERLSSGLRINSAK 
                 
                   CUGCCUGAUACAAC 
                 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 DDAAGQAIANRFTA 
                   AGGC GCCCAAGUGA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NIKGLTQASRNANDG 
                 UCAACACCAACAGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 ISIAQTTEGALNEINN 
                 CUGAGCCUGCUGAC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 NLQRVRELAVQSAN 
                 CCAGAACAACCUGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 GTNSQSDLDSIQAEIT 
                 ACAAGAGCCAGAGC 
                   
                 UCCCCC 
               
               
                   
                   
                 QRLNEIDRVSGQTQF 
                 GCCCUGGGCACAGC 
                   
                 CAGCCC 
               
               
                   
                   
                 NGVKVLAQDNTLTIQ 
                 CAUCGAAAGACUGU 
                   
                 CUCCUC 
               
               
                   
                   
                 VGANDGETIDIDLKEI 
                 CUAGCGGCCUGCGG 
                   
                 CCCUUC 
               
               
                   
                   
                 SSKTLGLDKLNVQDA 
                 AUCAACAGCGCCAA 
                   
                 CUGCAC 
               
               
                   
                   
                 YTPKETAVTVDKTTY 
                 AGAUGAUGCUGCCG 
                   
                 CCGUAC 
               
               
                   
                   
                 KNGTDPITAQSNTDI 
                 GACAGGCCAUUGCC 
                   
                 CCCCGU 
               
               
                   
                   
                 QTAIGGGATGVTGA 
                 AACAGAUUCACCGC 
                   
                 GGUCUU 
               
               
                   
                   
                 DIKFKDGQYYLDVK 
                 CAACAUCAAGGGCC 
                   
                 UGAAUA 
               
               
                   
                   
                 GGASAGVYKATYDE 
                 UGACACAGGCCAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 TTKKVNIDTTDKTPL 
                 AGAAACGCCAACGA 
                   
                 GAGUGG 
               
               
                   
                   
                 ATAEATAIRGTATITH 
                 CGGCAUCUCUAUCG 
                   
                 GCGGC 
               
               
                   
                   
                 NQIAEVTKEGVDTTT 
                 CCCAGACAACAGAA 
                   
                   
               
               
                   
                   
                 VAAQLAAAGVTGAD 
                 GGCGCCCUGAACGA 
                   
                   
               
               
                   
                   
                 KDNTSLVKLSFEDKN 
                 GAUCAACAACAACC 
                   
                   
               
               
                   
                   
                 GKVIDGGYAVKMGD 
                 UGCAGAGAGUGCGC 
                   
                   
               
               
                   
                   
                 DFYAATYDEKTGAIT 
                 GAGCUGGCCGUGCA 
                   
                   
               
               
                   
                   
                 AKTTTYTDGTGVAQ 
                 AUCUGCCAAUGGCA 
                   
                   
               
               
                   
                   
                 TGAVKFGGANGKSE 
                 CAAACAGCCAGUCC 
                   
                   
               
               
                   
                   
                 VVTATDGKTYLASD 
                 GACCUGGAUUCCAU 
                   
                   
               
               
                   
                   
                 LDKHNFRTGGELKEV 
                 CCAGGCCGAGAUCA 
                   
                   
               
               
                   
                   
                 NTDKTENPLQKIDAA 
                 CCCAGCGGCUGAAU 
                   
                   
               
               
                   
                   
                 LAQVDTLRSDLGAV 
                 GAGAUCGACAGAGU 
                   
                   
               
               
                   
                   
                 QNRFNSAITNLGNTV 
                 GUCCGGCCAGACAC 
                   
                   
               
               
                   
                   
                 NNLSSARSRIEDSDY 
                 AGUUCAACGGCGUG 
                   
                   
               
               
                   
                   
                 ATEVSNMSRAQILQQ 
                 AAAGUGCUGGCCCA 
                   
                   
               
               
                   
                   
                 AGTSVLAQANQVPQ 
                 GGACAACACCCUGA 
                   
                   
               
               
                   
                   
                 NVLSLLR 
                 CCAUCCAAGUGGGA 
                   
                   
               
               
                   
                   
                   
                 GCCAACGAUGGCGA 
                   
                   
               
               
                   
                   
                   
                 GACAAUCGACAUCG 
                   
                   
               
               
                   
                   
                   
                 ACCUGAAAGAGAUC 
                   
                   
               
               
                   
                   
                   
                 UCCAGCAAGACCCU 
                   
                   
               
               
                   
                   
                   
                 GGGCCUCGACAAGC 
                   
                   
               
               
                   
                   
                   
                 UGAACGUGCAGGAU 
                   
                   
               
               
                   
                   
                   
                 GCCUACACACCCAA 
                   
                   
               
               
                   
                   
                   
                 AGAAACCGCCGUGA 
                   
                   
               
               
                   
                   
                   
                 CCGUGGACAAGACC 
                   
                   
               
               
                   
                   
                   
                 ACCUACAAGAACGG 
                   
                   
               
               
                   
                   
                   
                 CACAGACCCCAUCA 
                   
                   
               
               
                   
                   
                   
                 CAGCCCAGAGCAAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAUAUCCAGAC 
                   
                   
               
               
                   
                   
                   
                 CGCCAUUGGAGGCG 
                   
                   
               
               
                   
                   
                   
                 GAGCUACAGGUGUU 
                   
                   
               
               
                   
                   
                   
                 ACAGGCGCCGACAU 
                   
                   
               
               
                   
                   
                   
                 CAAGUUCAAGGACG 
                   
                   
               
               
                   
                   
                   
                 GCCAGUACUACCUG 
                   
                   
               
               
                   
                   
                   
                 GACGUGAAAGGCGG 
                   
                   
               
               
                   
                   
                   
                 AGCAUCUGCCGGCG 
                   
                   
               
               
                   
                   
                   
                 UGUACAAGGCCACA 
                   
                   
               
               
                   
                   
                   
                 UACGACGAAACCAC 
                   
                   
               
               
                   
                   
                   
                 CAAGAAAGUGAACA 
                   
                   
               
               
                   
                   
                   
                 UCGACACCACCGAC 
                   
                   
               
               
                   
                   
                   
                 AAGACCCCUCUGGC 
                   
                   
               
               
                   
                   
                   
                 CACAGCUGAAGCCA 
                   
                   
               
               
                   
                   
                   
                 CAGCCAUUAGAGGC 
                   
                   
               
               
                   
                   
                   
                 ACCGCCACAAUCAC 
                   
                   
               
               
                   
                   
                   
                 CCACAACCAGAUCG 
                   
                   
               
               
                   
                   
                   
                 CCGAAGUGACCAAA 
                   
                   
               
               
                   
                   
                   
                 GAAGGCGUGGACAC 
                   
                   
               
               
                   
                   
                   
                 CACAACCGUGGCUG 
                   
                   
               
               
                   
                   
                   
                 CUCAACUUGCUGCU 
                   
                   
               
               
                   
                   
                   
                 GCUGGCGUUACCGG 
                   
                   
               
               
                   
                   
                   
                 CGCUGACAAGGAUA 
                   
                   
               
               
                   
                   
                   
                 AUACCAGCCUGGUC 
                   
                   
               
               
                   
                   
                   
                 AAGCUGAGCUUCGA 
                   
                   
               
               
                   
                   
                   
                 GGACAAGAAUGGCA 
                   
                   
               
               
                   
                   
                   
                 AAGUGAUCGACGGC 
                   
                   
               
               
                   
                   
                   
                 GGCUACGCCGUGAA 
                   
                   
               
               
                   
                   
                   
                 GAUGGGCGACGAUU 
                   
                   
               
               
                   
                   
                   
                 UCUACGCCGCCACC 
                   
                   
               
               
                   
                   
                   
                 UACGAUGAGAAGAC 
                   
                   
               
               
                   
                   
                   
                 CGGCGCCAUUACCG 
                   
                   
               
               
                   
                   
                   
                 CCAAGACCACAACC 
                   
                   
               
               
                   
                   
                   
                 UACACAGAUGGCAC 
                   
                   
               
               
                   
                   
                   
                 AGGCGUGGCACAGA 
                   
                   
               
               
                   
                   
                   
                 CAGGGGCCGUGAAA 
                   
                   
               
               
                   
                   
                   
                 UUUGGAGGCGCCAA 
                   
                   
               
               
                   
                   
                   
                 CGGCAAGAGCGAGG 
                   
                   
               
               
                   
                   
                   
                 UCGUGACAGCUACC 
                   
                   
               
               
                   
                   
                   
                 GACGGCAAGACAUA 
                   
                   
               
               
                   
                   
                   
                 CCUGGCCAGCGAUC 
                   
                   
               
               
                   
                   
                   
                 UGGACAAGCACAAC 
                   
                   
               
               
                   
                   
                   
                 UUCAGAACAGGCGG 
                   
                   
               
               
                   
                   
                   
                 CGAGCUGAAAGAAG 
                   
                   
               
               
                   
                   
                   
                 UGAACACAGACAAG 
                   
                   
               
               
                   
                   
                   
                 ACCGAGAAUCCGCU 
                   
                   
               
               
                   
                   
                   
                 GCAGAAGAUCGACG 
                   
                   
               
               
                   
                   
                   
                 CUGCUCUGGCACAA 
                   
                   
               
               
                   
                   
                   
                 GUGGACACCCUGAG 
                   
                   
               
               
                   
                   
                   
                 AAGUGAUCUGGGCG 
                   
                   
               
               
                   
                   
                   
                 CCGUGCAGAACAGG 
                   
                   
               
               
                   
                   
                   
                 UUCAACUCCGCCAU 
                   
                   
               
               
                   
                   
                   
                 CACCAACCUGGGCA 
                   
                   
               
               
                   
                   
                   
                 ACACCGUGAACAAU 
                   
                   
               
               
                   
                   
                   
                 CUGAGCAGCGCCAG 
                   
                   
               
               
                   
                   
                   
                 AAGCCGGAUCGAGG 
                   
                   
               
               
                   
                   
                   
                 ACAGCGAUUAUGCC 
                   
                   
               
               
                   
                   
                   
                 ACCGAGGUGUCCAA 
                   
                   
               
               
                   
                   
                   
                 CAUGAGCAGAGCCC 
                   
                   
               
               
                   
                   
                   
                 AGAUUCUGCAGCAG 
                   
                   
               
               
                   
                   
                   
                 GCCGGCACAUCUGU 
                   
                   
               
               
                   
                   
                   
                 UCUGGCUCAGGCAA 
                   
                   
               
               
                   
                   
                   
                 AUCAGGUGCCCCAG 
                   
                   
               
               
                   
                   
                   
                 AACGUGCUGUCCCU 
                   
                   
               
               
                   
                   
                   
                 GCUGAGA 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 39 
                 40 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 179 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 40, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 SpA_FliC_ 
                 MAQVINTNSLSLLTQ 
                 AUGGCCCAAGUGAU 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 cHis 
                 NNLNKSQSALGTAIE 
                 CAACACCAACAGCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 RLSSGLRINSAKDDA 
                 UGAGCCUGCUGACC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 AGQAIANRFTANIKG 
                 CAGAACAACCUGAA 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 LTQASRNANDGISIA 
                 CAAGAGCCAGAGCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 QTTEGALNEINNNLQ 
                 CCCUGGGCACAGCC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 RVRELAVQSANSTNS 
                 AUCGAAAGACUGUC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 QSDLDSIQAEITQRLN 
                 UAGCGGCCUGCGGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 EIDRVSGQTQFNGVK 
                 UCAACAGCGCCAAA 
                   
                 UCCCCC 
               
               
                   
                   
                 VLAQDNTLTIQVGAN 
                 GAUGAUGCUGCCGG 
                   
                 CAGCCC 
               
               
                   
                   
                 NGETIDIDLKQINSQT 
                 ACAGGCCAUUGCCA 
                   
                 CUCCUC 
               
               
                   
                   
                 LGLDTLNVQKKYDV 
                 ACAGAUUCACCGCC 
                   
                 CCCUUC 
               
               
                   
                   
                 KSEAVTPSATLSTTA 
                 AACAUCAAGGGCCU 
                   
                 CUGCAC 
               
               
                   
                   
                 LDGAGLKTGTGSTTD 
                 GACACAGGCCAGCA 
                   
                 CCGUAC 
               
               
                   
                   
                 TGSIKDGKVYYNSTS 
                 GAAACGCCAACGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 KNYYVEVEFTDATD 
                 GGCAUCUCUAUCGC 
                   
                 GGUCUU 
               
               
                   
                   
                 QTNKGGFYKVNVAD 
                 CCAGACAACAGAAG 
                   
                 UGAAUA 
               
               
                   
                   
                 DGAVTMTAATTKEA 
                 GCGCCCUGAACGAG 
                   
                 AAGUCU 
               
               
                   
                   
                 TTPTGITEVTQVQKP 
                 AUCAACAACAACCU 
                   
                 GAGUGG 
               
               
                   
                   
                 VAAPAAIQAQLTAAH 
                 GCAGAGAGUGCGCG 
                   
                 GCGGC 
               
               
                   
                   
                 VTGADTAEMVKMSY 
                 AGCUGGCCGUGCAG 
                   
                   
               
               
                   
                   
                 TDKNGKTIDGGFGVK 
                 UCUGCCAAUAGCAC 
                   
                   
               
               
                   
                   
                 VGADIYAATKNKDG 
                 AAACAGCCAGUCCG 
                   
                   
               
               
                   
                   
                 SFSINTTEYTDKDGN 
                 ACCUGGACAGCAUC 
                   
                   
               
               
                   
                   
                 TKTALNQLGGADGK 
                 CAGGCCGAGAUCAC 
                   
                   
               
               
                   
                   
                 TEVVSIDGKTYNASK 
                 CCAGCGGCUGAAUG 
                   
                   
               
               
                   
                   
                 AAGHNFKAQPELAE 
                 AGAUCGACAGAGUG 
                   
                   
               
               
                   
                   
                 AAAATTENPLAKIDA 
                 UCCGGCCAGACACA 
                   
                   
               
               
                   
                   
                 ALAQVDALRSDLGA 
                 GUUCAACGGCGUGA 
                   
                   
               
               
                   
                   
                 VQNRFNSAITNLGNT 
                 AAGUGCUGGCCCAG 
                   
                   
               
               
                   
                   
                 VNNLSSARSRIEDSD 
                 GACAACACCCUGAC 
                   
                   
               
               
                   
                   
                 YATEVSNMSRAQILQ 
                 CAUCCAAGUGGGAG 
                   
                   
               
               
                   
                   
                 QAGTSVLAQANQVP 
                 CCAACAACGGCGAG 
                   
                   
               
               
                   
                   
                 QNVLSLLRHHHHHH 
                 ACAAUCGACAUCGA 
                   
                   
               
               
                   
                   
                   
                 CCUGAAGCAGAUCA 
                   
                   
               
               
                   
                   
                   
                 ACUCUCAGACCCUG 
                   
                   
               
               
                   
                   
                   
                 GGCCUCGACACCCU 
                   
                   
               
               
                   
                   
                   
                 GAACGUGCAGAAGA 
                   
                   
               
               
                   
                   
                   
                 AGUACGACGUCAAG 
                   
                   
               
               
                   
                   
                   
                 AGCGAGGCCGUGAC 
                   
                   
               
               
                   
                   
                   
                 ACCUAGCGCCACAC 
                   
                   
               
               
                   
                   
                   
                 UGUCUACAACAGCC 
                   
                   
               
               
                   
                   
                   
                 CUGGAUGGCGCCGG 
                   
                   
               
               
                   
                   
                   
                 ACUCAAGACAGGCA 
                   
                   
               
               
                   
                   
                   
                 CAGGCAGCACAACA 
                   
                   
               
               
                   
                   
                   
                 GACACCGGCUCCAU 
                   
                   
               
               
                   
                   
                   
                 CAAGGACGGCAAGG 
                   
                   
               
               
                   
                   
                   
                 UGUACUACAACUCC 
                   
                   
               
               
                   
                   
                   
                 ACCAGCAAGAACUA 
                   
                   
               
               
                   
                   
                   
                 CUACGUCGAGGUGG 
                   
                   
               
               
                   
                   
                   
                 AAUUCACCGACGCC 
                   
                   
               
               
                   
                   
                   
                 ACCGACCAGACAAA 
                   
                   
               
               
                   
                   
                   
                 CAAAGGCGGCUUCU 
                   
                   
               
               
                   
                   
                   
                 ACAAAGUGAACGUG 
                   
                   
               
               
                   
                   
                   
                 GCCGACGAUGGGGC 
                   
                   
               
               
                   
                   
                   
                 CGUGACUAUGACAG 
                   
                   
               
               
                   
                   
                   
                 CCGCCACUACCAAA 
                   
                   
               
               
                   
                   
                   
                 GAGGCCACCACACC 
                   
                   
               
               
                   
                   
                   
                 UACAGGCAUCACCG 
                   
                   
               
               
                   
                   
                   
                 AAGUGACCCAGGUG 
                   
                   
               
               
                   
                   
                   
                 CAGAAACCUGUGGC 
                   
                   
               
               
                   
                   
                   
                 UGCCCCUGCUGCUA 
                   
                   
               
               
                   
                   
                   
                 UUCAGGCCCAACUG 
                   
                   
               
               
                   
                   
                   
                 ACAGCUGCCCAUGU 
                   
                   
               
               
                   
                   
                   
                 GACAGGCGCCGAUA 
                   
                   
               
               
                   
                   
                   
                 CAGCCGAGAUGGUC 
                   
                   
               
               
                   
                   
                   
                 AAGAUGAGCUACAC 
                   
                   
               
               
                   
                   
                   
                 CGACAAGAACGGCA 
                   
                   
               
               
                   
                   
                   
                 AGACCAUUGACGGC 
                   
                   
               
               
                   
                   
                   
                 GGCUUCGGAGUGAA 
                   
                   
               
               
                   
                   
                   
                 AGUGGGCGCCGACA 
                   
                   
               
               
                   
                   
                   
                 UCUAUGCCGCCACC 
                   
                   
               
               
                   
                   
                   
                 AAGAACAAGGAUGG 
                   
                   
               
               
                   
                   
                   
                 CAGCUUCAGCAUCA 
                   
                   
               
               
                   
                   
                   
                 AUACCACCGAGUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAUAAGGACGG 
                   
                   
               
               
                   
                   
                   
                 GAACACCAAGACAG 
                   
                   
               
               
                   
                   
                   
                 CCCUGAACCAGCUU 
                   
                   
               
               
                   
                   
                   
                 GGCGGAGCCGAUGG 
                   
                   
               
               
                   
                   
                   
                 AAAGACCGAGGUGG 
                   
                   
               
               
                   
                   
                   
                 UGUCUAUCGAUGGC 
                   
                   
               
               
                   
                   
                   
                 AAGACCUACAACGC 
                   
                   
               
               
                   
                   
                   
                 CAGCAAGGCCGCUG 
                   
                   
               
               
                   
                   
                   
                 GCCACAACUUUAAG 
                   
                   
               
               
                   
                   
                   
                 GCUCAGCCUGAACU 
                   
                   
               
               
                   
                   
                   
                 GGCCGAAGCUGCCG 
                   
                   
               
               
                   
                   
                   
                 CUGCUACCACAGAG 
                   
                   
               
               
                   
                   
                   
                 AAUCCUCUGGCCAA 
                   
                   
               
               
                   
                   
                   
                 GAUCGAUGCCGCUC 
                   
                   
               
               
                   
                   
                   
                 UGGCACAAGUGGAU 
                   
                   
               
               
                   
                   
                   
                 GCCCUGAGAAGUGA 
                   
                   
               
               
                   
                   
                   
                 UCUGGGCGCCGUGC 
                   
                   
               
               
                   
                   
                   
                 AGAACAGGUUCAAC 
                   
                   
               
               
                   
                   
                   
                 UCCGCCAUCACCAA 
                   
                   
               
               
                   
                   
                   
                 CCUGGGCAACACCG 
                   
                   
               
               
                   
                   
                   
                 UGAACAAUCUGAGC 
                   
                   
               
               
                   
                   
                   
                 AGCGCCAGAAGCCG 
                   
                   
               
               
                   
                   
                   
                 GAUCGAGGACAGCG 
                   
                   
               
               
                   
                   
                   
                 AUUAUGCCACCGAG 
                   
                   
               
               
                   
                   
                   
                 GUGUCCAACAUGAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGCCCAGAUUC 
                   
                   
               
               
                   
                   
                   
                 UGCAGCAGGCCGGC 
                   
                   
               
               
                   
                   
                   
                 ACAUCUGUUCUGGC 
                   
                   
               
               
                   
                   
                   
                 UCAGGCAAAUCAGG 
                   
                   
               
               
                   
                   
                   
                 UGCCCCAGAACGUG 
                   
                   
               
               
                   
                   
                   
                 CUGUCCCUGCUGAG 
                   
                   
               
               
                   
                   
                   
                 ACACCAUCACCACC 
                   
                   
               
               
                   
                   
                   
                 ACCAU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 41 
                 42 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 180 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 42, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 SpA_FliC 
                 MAQVINTNSLSLLTQ 
                 AUGGCCCAAGUGAU 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                   
                 NNLNKSQSALGTAIE 
                 CAACACCAACAGCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 RLSSGLRINSAKDDA 
                 UGAGCCUGCUGACC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 AGQAIANRFTANIKG 
                 CAGAACAACCUGAA 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 LTQASRNANDGISIA 
                 CAAGAGCCAGAGCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 QTTEGALNEINNNLQ 
                 CCCUGGGCACAGCC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 RVRELAVQSANSTNS 
                 AUCGAAAGACUGUC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 QSDLDSIQAEITQRLN 
                 UAGCGGCCUGCGGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 EIDRVSGQTQFNGVK 
                 UCAACAGCGCCAAA 
                   
                 UCCCCC 
               
               
                   
                   
                 VLAQDNTLTIQVGAN 
                 GAUGAUGCUGCCGG 
                   
                 CAGCCC 
               
               
                   
                   
                 NGETIDIDLKQINSQT 
                 ACAGGCCAUUGCCA 
                   
                 CUCCUC 
               
               
                   
                   
                 LGLDTLNVQKKYDV 
                 ACAGAUUCACCGCC 
                   
                 CCCUUC 
               
               
                   
                   
                 KSEAVTPSATLSTTA 
                 AACAUCAAGGGCCU 
                   
                 CUGCAC 
               
               
                   
                   
                 LDGAGLKTGTGSTTD 
                 GACACAGGCCAGCA 
                   
                 CCGUAC 
               
               
                   
                   
                 TGSIKDGKVYYNSTS 
                 GAAACGCCAACGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 KNYYVEVEFTDATD 
                 GGCAUCUCUAUCGC 
                   
                 GGUCUU 
               
               
                   
                   
                 QTNKGGFYKVNVAD 
                 CCAGACAACAGAAG 
                   
                 UGAAUA 
               
               
                   
                   
                 DGAVTMTAATTKEA 
                 GCGCCCUGAACGAG 
                   
                 AAGUCU 
               
               
                   
                   
                 TTPTGITEVTQVQKP 
                 AUCAACAACAACCU 
                   
                 GAGUGG 
               
               
                   
                   
                 VAAPAAIQAQLTAAH 
                 GCAGAGAGUGCGCG 
                   
                 GCGGC 
               
               
                   
                   
                 VTGADTAEMVKMSY 
                 AGCUGGCCGUGCAG 
                   
                   
               
               
                   
                   
                 TDKNGKTIDGGFGVK 
                 UCUGCCAAUAGCAC 
                   
                   
               
               
                   
                   
                 VGADIYAATKNKDG 
                 AAACAGCCAGUCCG 
                   
                   
               
               
                   
                   
                 SFSINTTEYTDKDGN 
                 ACCUGGACAGCAUC 
                   
                   
               
               
                   
                   
                 TKTALNQLGGADGK 
                 CAGGCCGAGAUCAC 
                   
                   
               
               
                   
                   
                 TEVVSIDGKTYNASK 
                 CCAGCGGCUGAAUG 
                   
                   
               
               
                   
                   
                 AAGHNFKAQPELAE 
                 AGAUCGACAGAGUG 
                   
                   
               
               
                   
                   
                 AAAATTENPLAKIDA 
                 UCCGGCCAGACACA 
                   
                   
               
               
                   
                   
                 ALAQVDALRSDLGA 
                 GUUCAACGGCGUGA 
                   
                   
               
               
                   
                   
                 VQNRFNSAITNLGNT 
                 AAGUGCUGGCCCAG 
                   
                   
               
               
                   
                   
                 VNNLSSARSRIEDSD 
                 GACAACACCCUGAC 
                   
                   
               
               
                   
                   
                 YATEVSNMSRAQILQ 
                 CAUCCAAGUGGGAG 
                   
                   
               
               
                   
                   
                 QAGTSVLAQANQVP 
                 CCAACAACGGCGAG 
                   
                   
               
               
                   
                   
                 QNVLSLLR 
                 ACAAUCGACAUCGA 
                   
                   
               
               
                   
                   
                   
                 CCUGAAGCAGAUCA 
                   
                   
               
               
                   
                   
                   
                 ACUCUCAGACCCUG 
                   
                   
               
               
                   
                   
                   
                 GGCCUCGACACCCU 
                   
                   
               
               
                   
                   
                   
                 GAACGUGCAGAAGA 
                   
                   
               
               
                   
                   
                   
                 AGUACGACGUCAAG 
                   
                   
               
               
                   
                   
                   
                 AGCGAGGCCGUGAC 
                   
                   
               
               
                   
                   
                   
                 ACCUAGCGCCACAC 
                   
                   
               
               
                   
                   
                   
                 UGUCUACAACAGCC 
                   
                   
               
               
                   
                   
                   
                 CUGGAUGGCGCCGG 
                   
                   
               
               
                   
                   
                   
                 ACUCAAGACAGGCA 
                   
                   
               
               
                   
                   
                   
                 CAGGCAGCACAACA 
                   
                   
               
               
                   
                   
                   
                 GACACCGGCUCCAU 
                   
                   
               
               
                   
                   
                   
                 CAAGGACGGCAAGG 
                   
                   
               
               
                   
                   
                   
                 UGUACUACAACUCC 
                   
                   
               
               
                   
                   
                   
                 ACCAGCAAGAACUA 
                   
                   
               
               
                   
                   
                   
                 CUACGUCGAGGUGG 
                   
                   
               
               
                   
                   
                   
                 AAUUCACCGACGCC 
                   
                   
               
               
                   
                   
                   
                 ACCGACCAGACAAA 
                   
                   
               
               
                   
                   
                   
                 CAAAGGCGGCUUCU 
                   
                   
               
               
                   
                   
                   
                 ACAAAGUGAACGUG 
                   
                   
               
               
                   
                   
                   
                 GCCGACGAUGGGGC 
                   
                   
               
               
                   
                   
                   
                 CGUGACUAUGACAG 
                   
                   
               
               
                   
                   
                   
                 CCGCCACUACCAAA 
                   
                   
               
               
                   
                   
                   
                 GAGGCCACCACACC 
                   
                   
               
               
                   
                   
                   
                 UACAGGCAUCACCG 
                   
                   
               
               
                   
                   
                   
                 AAGUGACCCAGGUG 
                   
                   
               
               
                   
                   
                   
                 CAGAAACCUGUGGC 
                   
                   
               
               
                   
                   
                   
                 UGCCCCUGCUGCUA 
                   
                   
               
               
                   
                   
                   
                 UUCAGGCCCAACUG 
                   
                   
               
               
                   
                   
                   
                 ACAGCUGCCCAUGU 
                   
                   
               
               
                   
                   
                   
                 GACAGGCGCCGAUA 
                   
                   
               
               
                   
                   
                   
                 CAGCCGAGAUGGUC 
                   
                   
               
               
                   
                   
                   
                 AAGAUGAGCUACAC 
                   
                   
               
               
                   
                   
                   
                 CGACAAGAACGGCA 
                   
                   
               
               
                   
                   
                   
                 AGACCAUUGACGGC 
                   
                   
               
               
                   
                   
                   
                 GGCUUCGGAGUGAA 
                   
                   
               
               
                   
                   
                   
                 AGUGGGCGCCGACA 
                   
                   
               
               
                   
                   
                   
                 UCUAUGCCGCCACC 
                   
                   
               
               
                   
                   
                   
                 AAGAACAAGGAUGG 
                   
                   
               
               
                   
                   
                   
                 CAGCUUCAGCAUCA 
                   
                   
               
               
                   
                   
                   
                 AUACCACCGAGUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAUAAGGACGG 
                   
                   
               
               
                   
                   
                   
                 GAACACCAAGACAG 
                   
                   
               
               
                   
                   
                   
                 CCCUGAACCAGCUU 
                   
                   
               
               
                   
                   
                   
                 GGCGGAGCCGAUGG 
                   
                   
               
               
                   
                   
                   
                 AAAGACCGAGGUGG 
                   
                   
               
               
                   
                   
                   
                 UGUCUAUCGAUGGC 
                   
                   
               
               
                   
                   
                   
                 AAGACCUACAACGC 
                   
                   
               
               
                   
                   
                   
                 CAGCAAGGCCGCUG 
                   
                   
               
               
                   
                   
                   
                 GCCACAACUUUAAG 
                   
                   
               
               
                   
                   
                   
                 GCUCAGCCUGAACU 
                   
                   
               
               
                   
                   
                   
                 GGCCGAAGCUGCCG 
                   
                   
               
               
                   
                   
                   
                 CUGCUACCACAGAG 
                   
                   
               
               
                   
                   
                   
                 AAUCCUCUGGCCAA 
                   
                   
               
               
                   
                   
                   
                 GAUCGAUGCCGCUC 
                   
                   
               
               
                   
                   
                   
                 UGGCACAAGUGGAU 
                   
                   
               
               
                   
                   
                   
                 GCCCUGAGAAGUGA 
                   
                   
               
               
                   
                   
                   
                 UCUGGGCGCCGUGC 
                   
                   
               
               
                   
                   
                   
                 AGAACAGGUUCAAC 
                   
                   
               
               
                   
                   
                   
                 UCCGCCAUCACCAA 
                   
                   
               
               
                   
                   
                   
                 CCUGGGCAACACCG 
                   
                   
               
               
                   
                   
                   
                 UGAACAAUCUGAGC 
                   
                   
               
               
                   
                   
                   
                 AGCGCCAGAAGCCG 
                   
                   
               
               
                   
                   
                   
                 GAUCGAGGACAGCG 
                   
                   
               
               
                   
                   
                   
                 AUUAUGCCACCGAG 
                   
                   
               
               
                   
                   
                   
                 GUGUCCAACAUGAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGCCCAGAUUC 
                   
                   
               
               
                   
                   
                   
                 UGCAGCAGGCCGGC 
                   
                   
               
               
                   
                   
                   
                 ACAUCUGUUCUGGC 
                   
                   
               
               
                   
                   
                   
                 UCAGGCAAAUCAGG 
                   
                   
               
               
                   
                   
                   
                 UGCCCCAGAACGUG 
                   
                   
               
               
                   
                   
                   
                 CUGUCCCUGCUGAG 
                   
                   
               
               
                   
                   
                   
                 A 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 43 
                 44 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 181 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 44, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 SpA_FliC_ 
                 METPAQLLFLLLLWL 
                 AUGGAAACCCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK_cHis 
                 PDTTAQVINTNSLSLL 
                 UCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 TQNNLNKSQSALGTA 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 IERLSSGLRINSAKDD 
                 CUGCCUGAUACAAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 AAGQAIANRFTANIK 
                 AGCCCAAGUGAUCA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 GLTQASRNANDGISI 
                 ACACCAACAGCCUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 AQTTEGALNEINNNL 
                 AGCCUGCUGACCCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 QRVRELAVQSANSTN 
                 GAACAACCUGAACA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 SQSDLDSIQAEITQRL 
                 AGAGCCAGAGCGCC 
                   
                 UCCCCC 
               
               
                   
                   
                 NEIDRVSGQTQFNGV 
                 CUGGGCACAGCCAU 
                   
                 CAGCCC 
               
               
                   
                   
                 KVLAQDNTLTIQVGA 
                 CGAAAGACUGUCUA 
                   
                 CUCCUC 
               
               
                   
                   
                 NNGETIDIDLKQINSQ 
                 GCGGCCUGCGGAUC 
                   
                 CCCUUC 
               
               
                   
                   
                 TLGLDTLNVQKKYD 
                 AACAGCGCCAAAGA 
                   
                 CUGCAC 
               
               
                   
                   
                 VKSEAVTPSATLSTT 
                 UGAUGCUGCCGGAC 
                   
                 CCGUAC 
               
               
                   
                   
                 ALDGAGLKTGTGSTT 
                 AGGCCAUUGCCAAC 
                   
                 CCCCGU 
               
               
                   
                   
                 DTGSIKDGKVYYNST 
                 AGAUUCACCGCCAA 
                   
                 GGUCUU 
               
               
                   
                   
                 SKNYYVEVEFTDATD 
                 CAUCAAGGGCCUGA 
                   
                 UGAAUA 
               
               
                   
                   
                 QTNKGGFYKVNVAD 
                 CACAGGCCAGCAGA 
                   
                 AAGUCU 
               
               
                   
                   
                 DGAVTMTAATTKEA 
                 AACGCCAACGACGG 
                   
                 GAGUGG 
               
               
                   
                   
                 TTPTGITEVTQVQKP 
                 CAUCUCUAUCGCCC 
                   
                 GCGGC 
               
               
                   
                   
                 VAAPAAIQAQLTAAH 
                 AGACAACAGAAGGC 
                   
                   
               
               
                   
                   
                 VTGADTAEMVKMSY 
                 GCCCUGAACGAGAU 
                   
                   
               
               
                   
                   
                 TDKNGKTIDGGFGVK 
                 CAACAACAACCUGC 
                   
                   
               
               
                   
                   
                 VGADIYAATKNKDG 
                 AGAGAGUGCGCGAG 
                   
                   
               
               
                   
                   
                 SFSINTTEYTDKDGN 
                 CUGGCCGUGCAGUC 
                   
                   
               
               
                   
                   
                 TKTALNQLGGADGK 
                 UGCCAAUAGCACAA 
                   
                   
               
               
                   
                   
                 TEVVSIDGKTYNASK 
                 ACAGCCAGUCCGAC 
                   
                   
               
               
                   
                   
                 AAGHNFKAQPELAE 
                 CUGGACAGCAUCCA 
                   
                   
               
               
                   
                   
                 AAAATTENPLAKIDA 
                 GGCCGAGAUCACCC 
                   
                   
               
               
                   
                   
                 ALAQVDALRSDLGA 
                 AGCGGCUGAAUGAG 
                   
                   
               
               
                   
                   
                 VQNRFNSAITNLGNT 
                 AUCGACAGAGUGUC 
                   
                   
               
               
                   
                   
                 VNNLSSARSRIEDSD 
                 CGGCCAGACACAGU 
                   
                   
               
               
                   
                   
                 YATEVSNMSRAQILQ 
                 UCAACGGCGUGAAA 
                   
                   
               
               
                   
                   
                 QAGTSVLAQANQVP 
                 GUGCUGGCCCAGGA 
                   
                   
               
               
                   
                   
                 QNVLSLLRHHHHHH 
                 CAACACCCUGACCA 
                   
                   
               
               
                   
                   
                   
                 UCCAAGUGGGAGCC 
                   
                   
               
               
                   
                   
                   
                 AACAACGGCGAGAC 
                   
                   
               
               
                   
                   
                   
                 AAUCGACAUCGACC 
                   
                   
               
               
                   
                   
                   
                 UGAAGCAGAUCAAC 
                   
                   
               
               
                   
                   
                   
                 UCUCAGACCCUGGG 
                   
                   
               
               
                   
                   
                   
                 CCUCGACACCCUGA 
                   
                   
               
               
                   
                   
                   
                 ACGUGCAGAAGAAG 
                   
                   
               
               
                   
                   
                   
                 UACGACGUCAAGAG 
                   
                   
               
               
                   
                   
                   
                 CGAGGCCGUGACAC 
                   
                   
               
               
                   
                   
                   
                 CUAGCGCCACACUG 
                   
                   
               
               
                   
                   
                   
                 UCUACAACAGCCCU 
                   
                   
               
               
                   
                   
                   
                 GGAUGGCGCCGGAC 
                   
                   
               
               
                   
                   
                   
                 UCAAGACAGGCACA 
                   
                   
               
               
                   
                   
                   
                 GGCAGCACAACAGA 
                   
                   
               
               
                   
                   
                   
                 CACCGGCUCCAUCA 
                   
                   
               
               
                   
                   
                   
                 AGGACGGCAAGGUG 
                   
                   
               
               
                   
                   
                   
                 UACUACAACUCCAC 
                   
                   
               
               
                   
                   
                   
                 CAGCAAGAACUACU 
                   
                   
               
               
                   
                   
                   
                 ACGUCGAGGUGGAA 
                   
                   
               
               
                   
                   
                   
                 UUCACCGACGCCAC 
                   
                   
               
               
                   
                   
                   
                 CGACCAGACAAACA 
                   
                   
               
               
                   
                   
                   
                 AAGGCGGCUUCUAC 
                   
                   
               
               
                   
                   
                   
                 AAAGUGAACGUGGC 
                   
                   
               
               
                   
                   
                   
                 CGACGAUGGGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGACUAUGACAGCC 
                   
                   
               
               
                   
                   
                   
                 GCCACUACCAAAGA 
                   
                   
               
               
                   
                   
                   
                 GGCCACCACACCUA 
                   
                   
               
               
                   
                   
                   
                 CAGGCAUCACCGAA 
                   
                   
               
               
                   
                   
                   
                 GUGACCCAGGUGCA 
                   
                   
               
               
                   
                   
                   
                 GAAACCUGUGGCUG 
                   
                   
               
               
                   
                   
                   
                 CCCCUGCUGCUAUU 
                   
                   
               
               
                   
                   
                   
                 CAGGCCCAACUGAC 
                   
                   
               
               
                   
                   
                   
                 AGCUGCCCAUGUGA 
                   
                   
               
               
                   
                   
                   
                 CAGGCGCCGAUACA 
                   
                   
               
               
                   
                   
                   
                 GCCGAGAUGGUCAA 
                   
                   
               
               
                   
                   
                   
                 GAUGAGCUACACCG 
                   
                   
               
               
                   
                   
                   
                 ACAAGAACGGCAAG 
                   
                   
               
               
                   
                   
                   
                 ACCAUUGACGGCGG 
                   
                   
               
               
                   
                   
                   
                 CUUCGGAGUGAAAG 
                   
                   
               
               
                   
                   
                   
                 UGGGCGCCGACAUC 
                   
                   
               
               
                   
                   
                   
                 UAUGCCGCCACCAA 
                   
                   
               
               
                   
                   
                   
                 GAACAAGGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 GCUUCAGCAUCAAU 
                   
                   
               
               
                   
                   
                   
                 ACCACCGAGUACAC 
                   
                   
               
               
                   
                   
                   
                 CGAUAAGGACGGGA 
                   
                   
               
               
                   
                   
                   
                 ACACCAAGACAGCC 
                   
                   
               
               
                   
                   
                   
                 CUGAACCAGCUUGG 
                   
                   
               
               
                   
                   
                   
                 CGGAGCCGAUGGAA 
                   
                   
               
               
                   
                   
                   
                 AGACCGAGGUGGUG 
                   
                   
               
               
                   
                   
                   
                 UCUAUCGAUGGCAA 
                   
                   
               
               
                   
                   
                   
                 GACCUACAACGCCA 
                   
                   
               
               
                   
                   
                   
                 GCAAGGCCGCUGGC 
                   
                   
               
               
                   
                   
                   
                 CACAACUUUAAGGC 
                   
                   
               
               
                   
                   
                   
                 UCAGCCUGAACUGG 
                   
                   
               
               
                   
                   
                   
                 CCGAAGCUGCCGCU 
                   
                   
               
               
                   
                   
                   
                 GCUACCACAGAGAA 
                   
                   
               
               
                   
                   
                   
                 UCCUCUGGCCAAGA 
                   
                   
               
               
                   
                   
                   
                 UCGAUGCCGCUCUG 
                   
                   
               
               
                   
                   
                   
                 GCACAAGUGGAUGC 
                   
                   
               
               
                   
                   
                   
                 CCUGAGAAGUGAUC 
                   
                   
               
               
                   
                   
                   
                 UGGGCGCCGUGCAG 
                   
                   
               
               
                   
                   
                   
                 AACAGGUUCAACUC 
                   
                   
               
               
                   
                   
                   
                 CGCCAUCACCAACC 
                   
                   
               
               
                   
                   
                   
                 UGGGCAACACCGUG 
                   
                   
               
               
                   
                   
                   
                 AACAAUCUGAGCAG 
                   
                   
               
               
                   
                   
                   
                 CGCCAGAAGCCGGA 
                   
                   
               
               
                   
                   
                   
                 UCGAGGACAGCGAU 
                   
                   
               
               
                   
                   
                   
                 UAUGCCACCGAGGU 
                   
                   
               
               
                   
                   
                   
                 GUCCAACAUGAGCA 
                   
                   
               
               
                   
                   
                   
                 GAGCCCAGAUUCUG 
                   
                   
               
               
                   
                   
                   
                 CAGCAGGCCGGCAC 
                   
                   
               
               
                   
                   
                   
                 AUCUGUUCUGGCUC 
                   
                   
               
               
                   
                   
                   
                 AGGCAAAUCAGGUG 
                   
                   
               
               
                   
                   
                   
                 CCCCAGAACGUGCU 
                   
                   
               
               
                   
                   
                   
                 GUCCCUGCUGAGAC 
                   
                   
               
               
                   
                   
                   
                 ACCAUCACCACCAC 
                   
                   
               
               
                   
                   
                   
                 CAU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 45 
                 46 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 182 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 46, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 SpA_FliC_ 
                 METPAQLLFLLLLWL 
                 AUGGAAACCCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK 
                 PDTTAQVINTNSLSLL 
                 UCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 TQNNLNKSQSALGTA 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 IERLSSGLRINSAKDD 
                 CUGCCUGAUACAAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 AAGQAIANRFTANIK 
                 AGCCCAAGUGAUCA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 GLTQASRNANDGISI 
                 ACACCAACAGCCUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 AQTTEGALNEINNNL 
                 AGCCUGCUGACCCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 QRVRELAVQSANSTN 
                 GAACAACCUGAACA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 SQSDLDSIQAEITQRL 
                 AGAGCCAGAGCGCC 
                   
                 UCCCCC 
               
               
                   
                   
                 NEIDRVSGQTQFNGV 
                 CUGGGCACAGCCAU 
                   
                 CAGCCC 
               
               
                   
                   
                 KVLAQDNTLTIQVGA 
                 CGAAAGACUGUCUA 
                   
                 CUCCUC 
               
               
                   
                   
                 NNGETIDIDLKQINSQ 
                 GCGGCCUGCGGAUC 
                   
                 CCCUUC 
               
               
                   
                   
                 TLGLDTLNVQKKYD 
                 AACAGCGCCAAAGA 
                   
                 CUGCAC 
               
               
                   
                   
                 VKSEAVTPSATLSTT 
                 UGAUGCUGCCGGAC 
                   
                 CCGUAC 
               
               
                   
                   
                 ALDGAGLKTGTGSTT 
                 AGGCCAUUGCCAAC 
                   
                 CCCCGU 
               
               
                   
                   
                 DTGSIKDGKVYYNST 
                 AGAUUCACCGCCAA 
                   
                 GGUCUU 
               
               
                   
                   
                 SKNYYVEVEFTDATD 
                 CAUCAAGGGCCUGA 
                   
                 UGAAUA 
               
               
                   
                   
                 QTNKGGFYKVNVAD 
                 CACAGGCCAGCAGA 
                   
                 AAGUCU 
               
               
                   
                   
                 DGAVTMTAATTKEA 
                 AACGCCAACGACGG 
                   
                 GAGUGG 
               
               
                   
                   
                 TTPTGITEVTQVQKP 
                 CAUCUCUAUCGCCC 
                   
                 GCGGC 
               
               
                   
                   
                 VAAPAAIQAQLTAAH 
                 AGACAACAGAAGGC 
                   
                   
               
               
                   
                   
                 VTGADTAEMVKMSY 
                 GCCCUGAACGAGAU 
                   
                   
               
               
                   
                   
                 TDKNGKTIDGGFGVK 
                 CAACAACAACCUGC 
                   
                   
               
               
                   
                   
                 VGADIYAATKNKDG 
                 AGAGAGUGCGCGAG 
                   
                   
               
               
                   
                   
                 SFSINTTEYTDKDGN 
                 CUGGCCGUGCAGUC 
                   
                   
               
               
                   
                   
                 TKTALNQLGGADGK 
                 UGCCAAUAGCACAA 
                   
                   
               
               
                   
                   
                 TEVVSIDGKTYNASK 
                 ACAGCCAGUCCGAC 
                   
                   
               
               
                   
                   
                 AAGHNFKAQPELAE 
                 CUGGACAGCAUCCA 
                   
                   
               
               
                   
                   
                 AAAATTENPLAKIDA 
                 GGCCGAGAUCACCC 
                   
                   
               
               
                   
                   
                 ALAQVDALRSDLGA 
                 AGCGGCUGAAUGAG 
                   
                   
               
               
                   
                   
                 VQNRFNSAITNLGNT 
                 AUCGACAGAGUGUC 
                   
                   
               
               
                   
                   
                 VNNLSSARSRIEDSD 
                 CGGCCAGACACAGU 
                   
                   
               
               
                   
                   
                 YATEVSNMSRAQILQ 
                 UCAACGGCGUGAAA 
                   
                   
               
               
                   
                   
                 QAGTSVLAQANQVP 
                 GUGCUGGCCCAGGA 
                   
                   
               
               
                   
                   
                 QNVLSLLR 
                 CAACACCCUGACCA 
                   
                   
               
               
                   
                   
                   
                 UCCAAGUGGGAGCC 
                   
                   
               
               
                   
                   
                   
                 AACAACGGCGAGAC 
                   
                   
               
               
                   
                   
                   
                 AAUCGACAUCGACC 
                   
                   
               
               
                   
                   
                   
                 UGAAGCAGAUCAAC 
                   
                   
               
               
                   
                   
                   
                 UCUCAGACCCUGGG 
                   
                   
               
               
                   
                   
                   
                 CCUCGACACCCUGA 
                   
                   
               
               
                   
                   
                   
                 ACGUGCAGAAGAAG 
                   
                   
               
               
                   
                   
                   
                 UACGACGUCAAGAG 
                   
                   
               
               
                   
                   
                   
                 CGAGGCCGUGACAC 
                   
                   
               
               
                   
                   
                   
                 CUAGCGCCACACUG 
                   
                   
               
               
                   
                   
                   
                 UCUACAACAGCCCU 
                   
                   
               
               
                   
                   
                   
                 GGAUGGCGCCGGAC 
                   
                   
               
               
                   
                   
                   
                 UCAAGACAGGCACA 
                   
                   
               
               
                   
                   
                   
                 GGCAGCACAACAGA 
                   
                   
               
               
                   
                   
                   
                 CACCGGCUCCAUCA 
                   
                   
               
               
                   
                   
                   
                 AGGACGGCAAGGUG 
                   
                   
               
               
                   
                   
                   
                 UACUACAACUCCAC 
                   
                   
               
               
                   
                   
                   
                 CAGCAAGAACUACU 
                   
                   
               
               
                   
                   
                   
                 ACGUCGAGGUGGAA 
                   
                   
               
               
                   
                   
                   
                 UUCACCGACGCCAC 
                   
                   
               
               
                   
                   
                   
                 CGACCAGACAAACA 
                   
                   
               
               
                   
                   
                   
                 AAGGCGGCUUCUAC 
                   
                   
               
               
                   
                   
                   
                 AAAGUGAACGUGGC 
                   
                   
               
               
                   
                   
                   
                 CGACGAUGGGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGACUAUGACAGCC 
                   
                   
               
               
                   
                   
                   
                 GCCACUACCAAAGA 
                   
                   
               
               
                   
                   
                   
                 GGCCACCACACCUA 
                   
                   
               
               
                   
                   
                   
                 CAGGCAUCACCGAA 
                   
                   
               
               
                   
                   
                   
                 GUGACCCAGGUGCA 
                   
                   
               
               
                   
                   
                   
                 GAAACCUGUGGCUG 
                   
                   
               
               
                   
                   
                   
                 CCCCUGCUGCUAUU 
                   
                   
               
               
                   
                   
                   
                 CAGGCCCAACUGAC 
                   
                   
               
               
                   
                   
                   
                 AGCUGCCCAUGUGA 
                   
                   
               
               
                   
                   
                   
                 CAGGCGCCGAUACA 
                   
                   
               
               
                   
                   
                   
                 GCCGAGAUGGUCAA 
                   
                   
               
               
                   
                   
                   
                 GAUGAGCUACACCG 
                   
                   
               
               
                   
                   
                   
                 ACAAGAACGGCAAG 
                   
                   
               
               
                   
                   
                   
                 ACCAUUGACGGCGG 
                   
                   
               
               
                   
                   
                   
                 CUUCGGAGUGAAAG 
                   
                   
               
               
                   
                   
                   
                 UGGGCGCCGACAUC 
                   
                   
               
               
                   
                   
                   
                 UAUGCCGCCACCAA 
                   
                   
               
               
                   
                   
                   
                 GAACAAGGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 GCUUCAGCAUCAAU 
                   
                   
               
               
                   
                   
                   
                 ACCACCGAGUACAC 
                   
                   
               
               
                   
                   
                   
                 CGAUAAGGACGGGA 
                   
                   
               
               
                   
                   
                   
                 ACACCAAGACAGCC 
                   
                   
               
               
                   
                   
                   
                 CUGAACCAGCUUGG 
                   
                   
               
               
                   
                   
                   
                 CGGAGCCGAUGGAA 
                   
                   
               
               
                   
                   
                   
                 AGACCGAGGUGGUG 
                   
                   
               
               
                   
                   
                   
                 UCUAUCGAUGGCAA 
                   
                   
               
               
                   
                   
                   
                 GACCUACAACGCCA 
                   
                   
               
               
                   
                   
                   
                 GCAAGGCCGCUGGC 
                   
                   
               
               
                   
                   
                   
                 CACAACUUUAAGGC 
                   
                   
               
               
                   
                   
                   
                 UCAGCCUGAACUGG 
                   
                   
               
               
                   
                   
                   
                 CCGAAGCUGCCGCU 
                   
                   
               
               
                   
                   
                   
                 GCUACCACAGAGAA 
                   
                   
               
               
                   
                   
                   
                 UCCUCUGGCCAAGA 
                   
                   
               
               
                   
                   
                   
                 UCGAUGCCGCUCUG 
                   
                   
               
               
                   
                   
                   
                 GCACAAGUGGAUGC 
                   
                   
               
               
                   
                   
                   
                 CCUGAGAAGUGAUC 
                   
                   
               
               
                   
                   
                   
                 UGGGCGCCGUGCAG 
                   
                   
               
               
                   
                   
                   
                 AACAGGUUCAACUC 
                   
                   
               
               
                   
                   
                   
                 CGCCAUCACCAACC 
                   
                   
               
               
                   
                   
                   
                 UGGGCAACACCGUG 
                   
                   
               
               
                   
                   
                   
                 AACAAUCUGAGCAG 
                   
                   
               
               
                   
                   
                   
                 CGCCAGAAGCCGGA 
                   
                   
               
               
                   
                   
                   
                 UCGAGGACAGCGAU 
                   
                   
               
               
                   
                   
                   
                 UAUGCCACCGAGGU 
                   
                   
               
               
                   
                   
                   
                 GUCCAACAUGAGCA 
                   
                   
               
               
                   
                   
                   
                 GAGCCCAGAUUCUG 
                   
                   
               
               
                   
                   
                   
                 CAGCAGGCCGGCAC 
                   
                   
               
               
                   
                   
                   
                 AUCUGUUCUGGCUC 
                   
                   
               
               
                   
                   
                   
                 AGGCAAAUCAGGUG 
                   
                   
               
               
                   
                   
                   
                 CCCCAGAACGUGCU 
                   
                   
               
               
                   
                   
                   
                 GUCCCUGCUGAGA 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 47 
                 48 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 183 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 48, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Stm_FliC_ 
                 MAQVINTNSLSLLTQ 
                 AUGGCCCAAGUGAU 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 cHis 
                 NNLNKSQSALGTAIE 
                 CAACACCAACAGCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 RLSSGLRINSAKDDA 
                 UGAGCCUGCUGACC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 AGQAIANRFTANIKG 
                 CAGAACAACCUGAA 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 LTQASRNANDGISIA 
                 CAAGAGCCAGAGCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 QTTEGALNEINNNLQ 
                 CCCUGGGCACAGCC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 RVRELAVQSANSTNS 
                 AUCGAAAGACUGUC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 QSDLDSIQAEITQRLN 
                 UAGCGGCCUGCGGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 EIDRVSGQTQFNGVK 
                 UCAACAGCGCCAAA 
                   
                 UCCCCC 
               
               
                   
                   
                 VLAQDNTLTIQVGAN 
                 GAUGAUGCUGCCGG 
                   
                 CAGCCC 
               
               
                   
                   
                 DGETIDIDLKQINSQT 
                 ACAGGCCAUUGCCA 
                   
                 CUCCUC 
               
               
                   
                   
                 LGLDTLNVQQKYKV 
                 ACAGAUUCACCGCC 
                   
                 CCCUUC 
               
               
                   
                   
                 SDTAATVTGYADTTI 
                 AACAUCAAGGGCCU 
                   
                 CUGCAC 
               
               
                   
                   
                 ALDNSTFKASATGLG 
                 GACACAGGCCAGCA 
                   
                 CCGUAC 
               
               
                   
                   
                 GTDQKIDGDLKFDDT 
                 GAAACGCCAACGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 TGKYYAKVTVTGGT 
                 GGCAUCUCUAUCGC 
                   
                 GGUCUU 
               
               
                   
                   
                 GKDGYYEVSVDKTN 
                 CCAGACAACAGAAG 
                   
                 UGAAUA 
               
               
                   
                   
                 GKVTLAGGATSPLTG 
                 GCGCCCUGAACGAG 
                   
                 AAGUCU 
               
               
                   
                   
                 GLPATATEDVKNVQ 
                 AUCAACAACAACCU 
                   
                 GAGUGG 
               
               
                   
                   
                 VANADLTEAKAALT 
                 GCAGAGAGUGCGCG 
                   
                 GCGGC 
               
               
                   
                   
                 AAGVTGTASVVKMS 
                 AGCUGGCCGUGCAG 
                   
                   
               
               
                   
                   
                 YTDNNGKTIDGGLA 
                 UCUGCCAAUAGCAC 
                   
                   
               
               
                   
                   
                 VKVGDDYYSATQNK 
                 AAACAGCCAGUCCG 
                   
                   
               
               
                   
                   
                 DGSISINTTKYTADD 
                 ACCUGGACAGCAUC 
                   
                   
               
               
                   
                   
                 GTSKTALNKLGGAD 
                 CAGGCCGAGAUCAC 
                   
                   
               
               
                   
                   
                 GKTEVVSIGGKTYAA 
                 CCAGCGGCUGAAUG 
                   
                   
               
               
                   
                   
                 SKAEGHNFKAQPDL 
                 AGAUCGACAGAGUG 
                   
                   
               
               
                   
                   
                 AEAAATTTENPLQKI 
                 UCCGGCCAGACACA 
                   
                   
               
               
                   
                   
                 DAALAQVDTLRSDL 
                 GUUCAACGGCGUGA 
                   
                   
               
               
                   
                   
                 GAVQNRFNSAITNLG 
                 AAGUGCUGGCCCAG 
                   
                   
               
               
                   
                   
                 NTVNNLTSARSRIED 
                 GACAACACCCUGAC 
                   
                   
               
               
                   
                   
                 SDYATEVSNMSRAQI 
                 CAUCCAAGUGGGAG 
                   
                   
               
               
                   
                   
                 LQQAGTSVLAQANQ 
                 CCAACGAUGGCGAG 
                   
                   
               
               
                   
                   
                 VPQNVLSLLRHHHH 
                 ACAAUCGACAUCGA 
                   
                   
               
               
                   
                   
                 HH 
                 CCUGAAGCAGAUCA 
                   
                   
               
               
                   
                   
                   
                 ACUCUCAGACCCUG 
                   
                   
               
               
                   
                   
                   
                 GGCCUCGACACCCU 
                   
                   
               
               
                   
                   
                   
                 GAACGUGCAGCAGA 
                   
                   
               
               
                   
                   
                   
                 AGUACAAGGUUUCC 
                   
                   
               
               
                   
                   
                   
                 GACACCGCCGCCAC 
                   
                   
               
               
                   
                   
                   
                 CGUGACAGGCUAUG 
                   
                   
               
               
                   
                   
                   
                 CCGAUACAACAAUC 
                   
                   
               
               
                   
                   
                   
                 GCCCUGGACAACAG 
                   
                   
               
               
                   
                   
                   
                 CACCUUCAAGGCCU 
                   
                   
               
               
                   
                   
                   
                 CUGCCACAGGCCUC 
                   
                   
               
               
                   
                   
                   
                 GGAGGCACCGAUCA 
                   
                   
               
               
                   
                   
                   
                 GAAGAUUGACGGCG 
                   
                   
               
               
                   
                   
                   
                 AUCUGAAGUUCGAC 
                   
                   
               
               
                   
                   
                   
                 GACACCACCGGCAA 
                   
                   
               
               
                   
                   
                   
                 GUACUACGCCAAAG 
                   
                   
               
               
                   
                   
                   
                 UGACAGUGACAGGC 
                   
                   
               
               
                   
                   
                   
                 GGCACAGGCAAGGA 
                   
                   
               
               
                   
                   
                   
                 CGGCUACUACGAAG 
                   
                   
               
               
                   
                   
                   
                 UGUCCGUGGACAAG 
                   
                   
               
               
                   
                   
                   
                 ACCAACGGCAAAGU 
                   
                   
               
               
                   
                   
                   
                 GACUCUGGCUGGCG 
                   
                   
               
               
                   
                   
                   
                 GAGCCACCUCUCCU 
                   
                   
               
               
                   
                   
                   
                 CUUACUGGUGGACU 
                   
                   
               
               
                   
                   
                   
                 UCCUGCCACCGCCA 
                   
                   
               
               
                   
                   
                   
                 CCGAGGACGUGAAG 
                   
                   
               
               
                   
                   
                   
                 AAUGUGCAGGUCGC 
                   
                   
               
               
                   
                   
                   
                 CAACGCCGAUCUGA 
                   
                   
               
               
                   
                   
                   
                 CCGAAGCUAAAGCC 
                   
                   
               
               
                   
                   
                   
                 GCUCUGACAGCUGC 
                   
                   
               
               
                   
                   
                   
                 UGGCGUGACCGGAA 
                   
                   
               
               
                   
                   
                   
                 CAGCCUCUGUGGUC 
                   
                   
               
               
                   
                   
                   
                 AAGAUGAGCUACAC 
                   
                   
               
               
                   
                   
                   
                 CGACAACAACGGCA 
                   
                   
               
               
                   
                   
                   
                 AGACCAUCGACGGC 
                   
                   
               
               
                   
                   
                   
                 GGACUGGCAGUGAA 
                   
                   
               
               
                   
                   
                   
                 AGUGGGCGACGAUU 
                   
                   
               
               
                   
                   
                   
                 ACUACAGCGCCACA 
                   
                   
               
               
                   
                   
                   
                 CAGAACAAGGAUGG 
                   
                   
               
               
                   
                   
                   
                 CAGCAUCUCCAUCA 
                   
                   
               
               
                   
                   
                   
                 AUACCACCAAGUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGCCGACGAUGG 
                   
                   
               
               
                   
                   
                   
                 CACCUCUAAGACCG 
                   
                   
               
               
                   
                   
                   
                 CUCUGAACAAACUC 
                   
                   
               
               
                   
                   
                   
                 GGCGGAGCCGAUGG 
                   
                   
               
               
                   
                   
                   
                 CAAGACCGAGGUGG 
                   
                   
               
               
                   
                   
                   
                 UGUCUAUCGGCGGC 
                   
                   
               
               
                   
                   
                   
                 AAGACAUACGCCGC 
                   
                   
               
               
                   
                   
                   
                 CUCUAAGGCCGAGG 
                   
                   
               
               
                   
                   
                   
                 GCCACAACUUUAAA 
                   
                   
               
               
                   
                   
                   
                 GCCCAGCCUGAUCU 
                   
                   
               
               
                   
                   
                   
                 GGCUGAGGCCGCUG 
                   
                   
               
               
                   
                   
                   
                 CCACUACCACAGAG 
                   
                   
               
               
                   
                   
                   
                 AAUCCUCUGCAGAA 
                   
                   
               
               
                   
                   
                   
                 GAUCGACGCCGCUC 
                   
                   
               
               
                   
                   
                   
                 UGGCACAAGUGGAU 
                   
                   
               
               
                   
                   
                   
                 ACCCUGAGAAGCGA 
                   
                   
               
               
                   
                   
                   
                 UCUGGGCGCCGUGC 
                   
                   
               
               
                   
                   
                   
                 AGAACAGGUUCAAU 
                   
                   
               
               
                   
                   
                   
                 AGCGCCAUCACCAA 
                   
                   
               
               
                   
                   
                   
                 CCUGGGCAACACCG 
                   
                   
               
               
                   
                   
                   
                 UGAACAAUCUGACC 
                   
                   
               
               
                   
                   
                   
                 AGCGCCAGAAGCCG 
                   
                   
               
               
                   
                   
                   
                 GAUCGAGGACAGCG 
                   
                   
               
               
                   
                   
                   
                 AUUAUGCCACAGAG 
                   
                   
               
               
                   
                   
                   
                 GUGUCCAACAUGAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGCCCAGAUCC 
                   
                   
               
               
                   
                   
                   
                 UGCAGCAGGCCGGA 
                   
                   
               
               
                   
                   
                   
                 ACAUCUGUUCUGGC 
                   
                   
               
               
                   
                   
                   
                 UCAGGCCAAUCAGG 
                   
                   
               
               
                   
                   
                   
                 UGCCCCAGAAUGUG 
                   
                   
               
               
                   
                   
                   
                 CUGUCCCUGCUGAG 
                   
                   
               
               
                   
                   
                   
                 ACACCAUCACCACC 
                   
                   
               
               
                   
                   
                   
                 ACCAU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 49 
                 50 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 184 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 50, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Stm_FliC 
                 MAQVINTNSLSLLTQ 
                 AUGGCCCAAGUGAU 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                   
                 NNLNKSQSALGTAIE 
                 CAACACCAACAGCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 RLSSGLRINSAKDDA 
                 UGAGCCUGCUGACC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 AGQAIANRFTANIKG 
                 CAGAACAACCUGAA 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 LTQASRNANDGISIA 
                 CAAGAGCCAGAGCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 QTTEGALNEINNNLQ 
                 CCCUGGGCACAGCC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 RVRELAVQSANSTNS 
                 AUCGAAAGACUGUC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 QSDLDSIQAEITQRLN 
                 UAGCGGCCUGCGGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 EIDRVSGQTQFNGVK 
                 UCAACAGCGCCAAA 
                   
                 UCCCCC 
               
               
                   
                   
                 VLAQDNTLTIQVGAN 
                 GAUGAUGCUGCCGG 
                   
                 CAGCCC 
               
               
                   
                   
                 DGETIDIDLKQINSQT 
                 ACAGGCCAUUGCCA 
                   
                 CUCCUC 
               
               
                   
                   
                 LGLDTLNVQQKYKV 
                 ACAGAUUCACCGCC 
                   
                 CCCUUC 
               
               
                   
                   
                 SDTAATVTGYADTTI 
                 AACAUCAAGGGCCU 
                   
                 CUGCAC 
               
               
                   
                   
                 ALDNSTFKASATGLG 
                 GACACAGGCCAGCA 
                   
                 CCGUAC 
               
               
                   
                   
                 GTDQKIDGDLKFDDT 
                 GAAACGCCAACGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 TGKYYAKVTVTGGT 
                 GGCAUCUCUAUCGC 
                   
                 GGUCUU 
               
               
                   
                   
                 GKDGYYEVSVDKTN 
                 CCAGACAACAGAAG 
                   
                 UGAAUA 
               
               
                   
                   
                 GKVTLAGGATSPLTG 
                 GCGCCCUGAACGAG 
                   
                 AAGUCU 
               
               
                   
                   
                 GLPATATEDVKNVQ 
                 AUCAACAACAACCU 
                   
                 GAGUGG 
               
               
                   
                   
                 VANADLTEAKAALT 
                 GCAGAGAGUGCGCG 
                   
                 GCGGC 
               
               
                   
                   
                 AAGVTGTASVVKMS 
                 AGCUGGCCGUGCAG 
                   
                   
               
               
                   
                   
                 YTDNNGKTIDGGLA 
                 UCUGCCAAUAGCAC 
                   
                   
               
               
                   
                   
                 VKVGDDYYSATQNK 
                 AAACAGCCAGUCCG 
                   
                   
               
               
                   
                   
                 DGSISINTTKYTADD 
                 ACCUGGACAGCAUC 
                   
                   
               
               
                   
                   
                 GTSKTALNKLGGAD 
                 CAGGCCGAGAUCAC 
                   
                   
               
               
                   
                   
                 GKTEVVSIGGKTYAA 
                 CCAGCGGCUGAAUG 
                   
                   
               
               
                   
                   
                 SKAEGHNFKAQPDL 
                 AGAUCGACAGAGUG 
                   
                   
               
               
                   
                   
                 AEAAATTTENPLQKI 
                 UCCGGCCAGACACA 
                   
                   
               
               
                   
                   
                 DAALAQVDTLRSDL 
                 GUUCAACGGCGUGA 
                   
                   
               
               
                   
                   
                 GAVQNRFNSAITNLG 
                 AAGUGCUGGCCCAG 
                   
                   
               
               
                   
                   
                 NTVNNLTSARSRIED 
                 GACAACACCCUGAC 
                   
                   
               
               
                   
                   
                 SDYATEVSNMSRAQI 
                 CAUCCAAGUGGGAG 
                   
                   
               
               
                   
                   
                 LQQAGTSVLAQANQ 
                 CCAACGAUGGCGAG 
                   
                   
               
               
                   
                   
                 VPQNVLSLLR 
                 ACAAUCGACAUCGA 
                   
                   
               
               
                   
                   
                   
                 CCUGAAGCAGAUCA 
                   
                   
               
               
                   
                   
                   
                 ACUCUCAGACCCUG 
                   
                   
               
               
                   
                   
                   
                 GGCCUCGACACCCU 
                   
                   
               
               
                   
                   
                   
                 GAACGUGCAGCAGA 
                   
                   
               
               
                   
                   
                   
                 AGUACAAGGUUUCC 
                   
                   
               
               
                   
                   
                   
                 GACACCGCCGCCAC 
                   
                   
               
               
                   
                   
                   
                 CGUGACAGGCUAUG 
                   
                   
               
               
                   
                   
                   
                 CCGAUACAACAAUC 
                   
                   
               
               
                   
                   
                   
                 GCCCUGGACAACAG 
                   
                   
               
               
                   
                   
                   
                 CACCUUCAAGGCCU 
                   
                   
               
               
                   
                   
                   
                 CUGCCACAGGCCUC 
                   
                   
               
               
                   
                   
                   
                 GGAGGCACCGAUCA 
                   
                   
               
               
                   
                   
                   
                 GAAGAUUGACGGCG 
                   
                   
               
               
                   
                   
                   
                 AUCUGAAGUUCGAC 
                   
                   
               
               
                   
                   
                   
                 GACACCACCGGCAA 
                   
                   
               
               
                   
                   
                   
                 GUACUACGCCAAAG 
                   
                   
               
               
                   
                   
                   
                 UGACAGUGACAGGC 
                   
                   
               
               
                   
                   
                   
                 GGCACAGGCAAGGA 
                   
                   
               
               
                   
                   
                   
                 CGGCUACUACGAAG 
                   
                   
               
               
                   
                   
                   
                 UGUCCGUGGACAAG 
                   
                   
               
               
                   
                   
                   
                 ACCAACGGCAAAGU 
                   
                   
               
               
                   
                   
                   
                 GACUCUGGCUGGCG 
                   
                   
               
               
                   
                   
                   
                 GAGCCACCUCUCCU 
                   
                   
               
               
                   
                   
                   
                 CUUACUGGUGGACU 
                   
                   
               
               
                   
                   
                   
                 UCCUGCCACCGCCA 
                   
                   
               
               
                   
                   
                   
                 CCGAGGACGUGAAG 
                   
                   
               
               
                   
                   
                   
                 AAUGUGCAGGUCGC 
                   
                   
               
               
                   
                   
                   
                 CAACGCCGAUCUGA 
                   
                   
               
               
                   
                   
                   
                 CCGAAGCUAAAGCC 
                   
                   
               
               
                   
                   
                   
                 GCUCUGACAGCUGC 
                   
                   
               
               
                   
                   
                   
                 UGGCGUGACCGGAA 
                   
                   
               
               
                   
                   
                   
                 CAGCCUCUGUGGUC 
                   
                   
               
               
                   
                   
                   
                 AAGAUGAGCUACAC 
                   
                   
               
               
                   
                   
                   
                 CGACAACAACGGCA 
                   
                   
               
               
                   
                   
                   
                 AGACCAUCGACGGC 
                   
                   
               
               
                   
                   
                   
                 GGACUGGCAGUGAA 
                   
                   
               
               
                   
                   
                   
                 AGUGGGCGACGAUU 
                   
                   
               
               
                   
                   
                   
                 ACUACAGCGCCACA 
                   
                   
               
               
                   
                   
                   
                 CAGAACAAGGAUGG 
                   
                   
               
               
                   
                   
                   
                 CAGCAUCUCCAUCA 
                   
                   
               
               
                   
                   
                   
                 AUACCACCAAGUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGCCGACGAUGG 
                   
                   
               
               
                   
                   
                   
                 CACCUCUAAGACCG 
                   
                   
               
               
                   
                   
                   
                 CUCUGAACAAACUC 
                   
                   
               
               
                   
                   
                   
                 GGCGGAGCCGAUGG 
                   
                   
               
               
                   
                   
                   
                 CAAGACCGAGGUGG 
                   
                   
               
               
                   
                   
                   
                 UGUCUAUCGGCGGC 
                   
                   
               
               
                   
                   
                   
                 AAGACAUACGCCGC 
                   
                   
               
               
                   
                   
                   
                 CUCUAAGGCCGAGG 
                   
                   
               
               
                   
                   
                   
                 GCCACAACUUUAAA 
                   
                   
               
               
                   
                   
                   
                 GCCCAGCCUGAUCU 
                   
                   
               
               
                   
                   
                   
                 GGCUGAGGCCGCUG 
                   
                   
               
               
                   
                   
                   
                 CCACUACCACAGAG 
                   
                   
               
               
                   
                   
                   
                 AAUCCUCUGCAGAA 
                   
                   
               
               
                   
                   
                   
                 GAUCGACGCCGCUC 
                   
                   
               
               
                   
                   
                   
                 UGGCACAAGUGGAU 
                   
                   
               
               
                   
                   
                   
                 ACCCUGAGAAGCGA 
                   
                   
               
               
                   
                   
                   
                 UCUGGGCGCCGUGC 
                   
                   
               
               
                   
                   
                   
                 AGAACAGGUUCAAU 
                   
                   
               
               
                   
                   
                   
                 AGCGCCAUCACCAA 
                   
                   
               
               
                   
                   
                   
                 CCUGGGCAACACCG 
                   
                   
               
               
                   
                   
                   
                 UGAACAAUCUGACC 
                   
                   
               
               
                   
                   
                   
                 AGCGCCAGAAGCCG 
                   
                   
               
               
                   
                   
                   
                 GAUCGAGGACAGCG 
                   
                   
               
               
                   
                   
                   
                 AUUAUGCCACAGAG 
                   
                   
               
               
                   
                   
                   
                 GUGUCCAACAUGAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGCCCAGAUCC 
                   
                   
               
               
                   
                   
                   
                 UGCAGCAGGCCGGA 
                   
                   
               
               
                   
                   
                   
                 ACAUCUGUUCUGGC 
                   
                   
               
               
                   
                   
                   
                 UCAGGCCAAUCAGG 
                   
                   
               
               
                   
                   
                   
                 UGCCCCAGAAUGUG 
                   
                   
               
               
                   
                   
                   
                 CUGUCCCUGCUGAG 
                   
                   
               
               
                   
                   
                   
                 A 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 51 
                 52 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 185 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 52, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Stm_FliC_ 
                 METPAQLLFLLLLWL 
                 AUGGAAACCCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK_cHis 
                 PDTTAQVINTNSLSLL 
                 UCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 TQNNLNKSQSALGTA 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 IERLSSGLRINSAKDD 
                 CUGCCUGAUACAAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 AAGQAIANRFTANIK 
                 AGCCCAAGUGAUCA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 GLTQASRNANDGISI 
                 ACACCAACAGCCUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 AQTTEGALNEINNNL 
                 AGCCUGCUGACCCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 QRVRELAVQSANSTN 
                 GAACAACCUGAACA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 SQSDLDSIQAEITQRL 
                 AGAGCCAGAGCGCC 
                   
                 UCCCCC 
               
               
                   
                   
                 NEIDRVSGQTQFNGV 
                 CUGGGCACAGCCAU 
                   
                 CAGCCC 
               
               
                   
                   
                 KVLAQDNTLTIQVGA 
                 CGAAAGACUGUCUA 
                   
                 CUCCUC 
               
               
                   
                   
                 NDGETIDIDLKQINSQ 
                 GCGGCCUGCGGAUC 
                   
                 CCCUUC 
               
               
                   
                   
                 TLGLDTLNVQQKYK 
                 AACAGCGCCAAAGA 
                   
                 CUGCAC 
               
               
                   
                   
                 VSDTAATVTGYADT 
                 UGAUGCUGCCGGAC 
                   
                 CCGUAC 
               
               
                   
                   
                 TIALDNSTFKASATG 
                 AGGCCAUUGCCAAC 
                   
                 CCCCGU 
               
               
                   
                   
                 LGGTDQKIDGDLKFD 
                 AGAUUCACCGCCAA 
                   
                 GGUCUU 
               
               
                   
                   
                 DTTGKYYAKVTVTG 
                 CAUCAAGGGCCUGA 
                   
                 UGAAUA 
               
               
                   
                   
                 GTGKDGYYEVSVDK 
                 CACAGGCCAGCAGA 
                   
                 AAGUCU 
               
               
                   
                   
                 TNGKVTLAGGATSPL 
                 AACGCCAACGACGG 
                   
                 GAGUGG 
               
               
                   
                   
                 TGGLPATATEDVKN 
                 CAUCUCUAUCGCCC 
                   
                 GCGGC 
               
               
                   
                   
                 VQVANADLTEAKAA 
                 AGACAACAGAAGGC 
                   
                   
               
               
                   
                   
                 LTAAGVTGTASVVK 
                 GCCCUGAACGAGAU 
                   
                   
               
               
                   
                   
                 MSYTDNNGKTIDGG 
                 CAACAACAACCUGC 
                   
                   
               
               
                   
                   
                 LAVKVGDDYYSATQ 
                 AGAGAGUGCGCGAG 
                   
                   
               
               
                   
                   
                 NKDGSISINTTKYTA 
                 CUGGCCGUGCAGUC 
                   
                   
               
               
                   
                   
                 DDGTSKTALNKLGG 
                 UGCCAAUAGCACAA 
                   
                   
               
               
                   
                   
                 ADGKTEVVSIGGKTY 
                 ACAGCCAGUCCGAC 
                   
                   
               
               
                   
                   
                 AASKAEGHNFKAQP 
                 CUGGACAGCAUCCA 
                   
                   
               
               
                   
                   
                 DLAEAAATTTENPLQ 
                 GGCCGAGAUCACCC 
                   
                   
               
               
                   
                   
                 KIDAALAQVDTLRSD 
                 AGCGGCUGAAUGAG 
                   
                   
               
               
                   
                   
                 LGAVQNRFNSAITNL 
                 AUCGACAGAGUGUC 
                   
                   
               
               
                   
                   
                 GNTVNNLTSARSRIE 
                 CGGCCAGACACAGU 
                   
                   
               
               
                   
                   
                 DSDYATEVSNMSRA 
                 UCAACGGCGUGAAA 
                   
                   
               
               
                   
                   
                 QILQQAGTSVLAQAN 
                 GUGCUGGCCCAGGA 
                   
                   
               
               
                   
                   
                 QVPQNVLSLLRHHH 
                 CAACACCCUGACCA 
                   
                   
               
               
                   
                   
                 HHH 
                 UCCAAGUGGGAGCC 
                   
                   
               
               
                   
                   
                   
                 AACGAUGGCGAGAC 
                   
                   
               
               
                   
                   
                   
                 AAUCGACAUCGACC 
                   
                   
               
               
                   
                   
                   
                 UGAAGCAGAUCAAC 
                   
                   
               
               
                   
                   
                   
                 UCUCAGACCCUGGG 
                   
                   
               
               
                   
                   
                   
                 CCUCGACACCCUGA 
                   
                   
               
               
                   
                   
                   
                 ACGUGCAGCAGAAG 
                   
                   
               
               
                   
                   
                   
                 UACAAGGUUUCCGA 
                   
                   
               
               
                   
                   
                   
                 CACCGCCGCCACCG 
                   
                   
               
               
                   
                   
                   
                 UGACAGGCUAUGCC 
                   
                   
               
               
                   
                   
                   
                 GAUACAACAAUCGC 
                   
                   
               
               
                   
                   
                   
                 CCUGGACAACAGCA 
                   
                   
               
               
                   
                   
                   
                 CCUUCAAGGCCUCU 
                   
                   
               
               
                   
                   
                   
                 GCCACAGGCCUCGG 
                   
                   
               
               
                   
                   
                   
                 AGGCACCGAUCAGA 
                   
                   
               
               
                   
                   
                   
                 AGAUUGACGGCGAU 
                   
                   
               
               
                   
                   
                   
                 CUGAAGUUCGACGA 
                   
                   
               
               
                   
                   
                   
                 CACCACCGGCAAGU 
                   
                   
               
               
                   
                   
                   
                 ACUACGCCAAAGUG 
                   
                   
               
               
                   
                   
                   
                 ACAGUGACAGGCGG 
                   
                   
               
               
                   
                   
                   
                 CACAGGCAAGGACG 
                   
                   
               
               
                   
                   
                   
                 GCUACUACGAAGUG 
                   
                   
               
               
                   
                   
                   
                 UCCGUGGACAAGAC 
                   
                   
               
               
                   
                   
                   
                 CAACGGCAAAGUGA 
                   
                   
               
               
                   
                   
                   
                 CUCUGGCUGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCCACCUCUCCUCU 
                   
                   
               
               
                   
                   
                   
                 UACUGGUGGACUUC 
                   
                   
               
               
                   
                   
                   
                 CUGCCACCGCCACC 
                   
                   
               
               
                   
                   
                   
                 GAGGACGUGAAGAA 
                   
                   
               
               
                   
                   
                   
                 UGUGCAGGUCGCCA 
                   
                   
               
               
                   
                   
                   
                 ACGCCGAUCUGACC 
                   
                   
               
               
                   
                   
                   
                 GAAGCUAAAGCCGC 
                   
                   
               
               
                   
                   
                   
                 UCUGACAGCUGCUG 
                   
                   
               
               
                   
                   
                   
                 GCGUGACCGGAACA 
                   
                   
               
               
                   
                   
                   
                 GCCUCUGUGGUCAA 
                   
                   
               
               
                   
                   
                   
                 GAUGAGCUACACCG 
                   
                   
               
               
                   
                   
                   
                 ACAACAACGGCAAG 
                   
                   
               
               
                   
                   
                   
                 ACCAUCGACGGCGG 
                   
                   
               
               
                   
                   
                   
                 ACUGGCAGUGAAAG 
                   
                   
               
               
                   
                   
                   
                 UGGGCGACGAUUAC 
                   
                   
               
               
                   
                   
                   
                 UACAGCGCCACACA 
                   
                   
               
               
                   
                   
                   
                 GAACAAGGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 GCAUCUCCAUCAAU 
                   
                   
               
               
                   
                   
                   
                 ACCACCAAGUACAC 
                   
                   
               
               
                   
                   
                   
                 CGCCGACGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 CCUCUAAGACCGCU 
                   
                   
               
               
                   
                   
                   
                 CUGAACAAACUCGG 
                   
                   
               
               
                   
                   
                   
                 CGGAGCCGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 AGACCGAGGUGGUG 
                   
                   
               
               
                   
                   
                   
                 UCUAUCGGCGGCAA 
                   
                   
               
               
                   
                   
                   
                 GACAUACGCCGCCU 
                   
                   
               
               
                   
                   
                   
                 CUAAGGCCGAGGGC 
                   
                   
               
               
                   
                   
                   
                 CACAACUUUAAAGC 
                   
                   
               
               
                   
                   
                   
                 CCAGCCUGAUCUGG 
                   
                   
               
               
                   
                   
                   
                 CUGAGGCCGCUGCC 
                   
                   
               
               
                   
                   
                   
                 ACUACCACAGAGAA 
                   
                   
               
               
                   
                   
                   
                 UCCUCUGCAGAAGA 
                   
                   
               
               
                   
                   
                   
                 UCGACGCCGCUCUG 
                   
                   
               
               
                   
                   
                   
                 GCACAAGUGGAUAC 
                   
                   
               
               
                   
                   
                   
                 CCUGAGAAGCGAUC 
                   
                   
               
               
                   
                   
                   
                 UGGGCGCCGUGCAG 
                   
                   
               
               
                   
                   
                   
                 AACAGGUUCAAUAG 
                   
                   
               
               
                   
                   
                   
                 CGCCAUCACCAACC 
                   
                   
               
               
                   
                   
                   
                 UGGGCAACACCGUG 
                   
                   
               
               
                   
                   
                   
                 AACAAUCUGACCAG 
                   
                   
               
               
                   
                   
                   
                 CGCCAGAAGCCGGA 
                   
                   
               
               
                   
                   
                   
                 UCGAGGACAGCGAU 
                   
                   
               
               
                   
                   
                   
                 UAUGCCACAGAGGU 
                   
                   
               
               
                   
                   
                   
                 GUCCAACAUGAGCA 
                   
                   
               
               
                   
                   
                   
                 GAGCCCAGAUCCUG 
                   
                   
               
               
                   
                   
                   
                 CAGCAGGCCGGAAC 
                   
                   
               
               
                   
                   
                   
                 AUCUGUUCUGGCUC 
                   
                   
               
               
                   
                   
                   
                 AGGCCAAUCAGGUG 
                   
                   
               
               
                   
                   
                   
                 CCCCAGAAUGUGCU 
                   
                   
               
               
                   
                   
                   
                 GUCCCUGCUGAGAC 
                   
                   
               
               
                   
                   
                   
                 ACCAUCACCACCAC 
                   
                   
               
               
                   
                   
                   
                 CAU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 53 
                 54 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 186 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 54, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Stm_FliC_ 
                 METPAQLLFLLLLWL 
                 AUGGAAACCCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK 
                 PDTTAQVINTNSLSLL 
                 UCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 TQNNLNKSQSALGTA 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 IERLSSGLRINSAKDD 
                 CUGCCUGAUACAAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 AAGQAIANRFTANIK 
                 AGCCCAAGUGAUCA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 GLTQASRNANDGISI 
                 ACACCAACAGCCUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 AQTTEGALNEINNNL 
                 AGCCUGCUGACCCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 QRVRELAVQSANSTN 
                 GAACAACCUGAACA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 SQSDLDSIQAEITQRL 
                 AGAGCCAGAGCGCC 
                   
                 UCCCCC 
               
               
                   
                   
                 NEIDRVSGQTQFNGV 
                 CUGGGCACAGCCAU 
                   
                 CAGCCC 
               
               
                   
                   
                 KVLAQDNTLTIQVGA 
                 CGAAAGACUGUCUA 
                   
                 CUCCUC 
               
               
                   
                   
                 NDGETIDIDLKQINSQ 
                 GCGGCCUGCGGAUC 
                   
                 CCCUUC 
               
               
                   
                   
                 TLGLDTLNVQQKYK 
                 AACAGCGCCAAAGA 
                   
                 CUGCAC 
               
               
                   
                   
                 VSDTAATVTGYADT 
                 UGAUGCUGCCGGAC 
                   
                 CCGUAC 
               
               
                   
                   
                 TIALDNSTFKASATG 
                 AGGCCAUUGCCAAC 
                   
                 CCCCGU 
               
               
                   
                   
                 LGGTDQKIDGDLKFD 
                 AGAUUCACCGCCAA 
                   
                 GGUCUU 
               
               
                   
                   
                 DTTGKYYAKVTVTG 
                 CAUCAAGGGCCUGA 
                   
                 UGAAUA 
               
               
                   
                   
                 GTGKDGYYEVSVDK 
                 CACAGGCCAGCAGA 
                   
                 AAGUCU 
               
               
                   
                   
                 TNGKVTLAGGATSPL 
                 AACGCCAACGACGG 
                   
                 GAGUGG 
               
               
                   
                   
                 TGGLPATATEDVKN 
                 CAUCUCUAUCGCCC 
                   
                 GCGGC 
               
               
                   
                   
                 VQVANADLTEAKAA 
                 AGACAACAGAAGGC 
                   
                   
               
               
                   
                   
                 LTAAGVTGTASVVK 
                 GCCCUGAACGAGAU 
                   
                   
               
               
                   
                   
                 MSYTDNNGKTIDGG 
                 CAACAACAACCUGC 
                   
                   
               
               
                   
                   
                 LAVKVGDDYYSATQ 
                 AGAGAGUGCGCGAG 
                   
                   
               
               
                   
                   
                 NKDGSISINTTKYTA 
                 CUGGCCGUGCAGUC 
                   
                   
               
               
                   
                   
                 DDGTSKTALNKLGG 
                 UGCCAAUAGCACAA 
                   
                   
               
               
                   
                   
                 ADGKTEVVSIGGKTY 
                 ACAGCCAGUCCGAC 
                   
                   
               
               
                   
                   
                 AASKAEGHNFKAQP 
                 CUGGACAGCAUCCA 
                   
                   
               
               
                   
                   
                 DLAEAAATTTENPLQ 
                 GGCCGAGAUCACCC 
                   
                   
               
               
                   
                   
                 KIDAALAQVDTLRSD 
                 AGCGGCUGAAUGAG 
                   
                   
               
               
                   
                   
                 LGAVQNRFNSAITNL 
                 AUCGACAGAGUGUC 
                   
                   
               
               
                   
                   
                 GNTVNNLTSARSRIE 
                 CGGCCAGACACAGU 
                   
                   
               
               
                   
                   
                 DSDYATEVSNMSRA 
                 UCAACGGCGUGAAA 
                   
                   
               
               
                   
                   
                 QILQQAGTSVLAQAN 
                 GUGCUGGCCCAGGA 
                   
                   
               
               
                   
                   
                 QVPQNVLSLLR 
                 CAACACCCUGACCA 
                   
                   
               
               
                   
                   
                   
                 UCCAAGUGGGAGCC 
                   
                   
               
               
                   
                   
                   
                 AACGAUGGCGAGAC 
                   
                   
               
               
                   
                   
                   
                 AAUCGACAUCGACC 
                   
                   
               
               
                   
                   
                   
                 UGAAGCAGAUCAAC 
                   
                   
               
               
                   
                   
                   
                 UCUCAGACCCUGGG 
                   
                   
               
               
                   
                   
                   
                 CCUCGACACCCUGA 
                   
                   
               
               
                   
                   
                   
                 ACGUGCAGCAGAAG 
                   
                   
               
               
                   
                   
                   
                 UACAAGGUUUCCGA 
                   
                   
               
               
                   
                   
                   
                 CACCGCCGCCACCG 
                   
                   
               
               
                   
                   
                   
                 UGACAGGCUAUGCC 
                   
                   
               
               
                   
                   
                   
                 GAUACAACAAUCGC 
                   
                   
               
               
                   
                   
                   
                 CCUGGACAACAGCA 
                   
                   
               
               
                   
                   
                   
                 CCUUCAAGGCCUCU 
                   
                   
               
               
                   
                   
                   
                 GCCACAGGCCUCGG 
                   
                   
               
               
                   
                   
                   
                 AGGCACCGAUCAGA 
                   
                   
               
               
                   
                   
                   
                 AGAUUGACGGCGAU 
                   
                   
               
               
                   
                   
                   
                 CUGAAGUUCGACGA 
                   
                   
               
               
                   
                   
                   
                 CACCACCGGCAAGU 
                   
                   
               
               
                   
                   
                   
                 ACUACGCCAAAGUG 
                   
                   
               
               
                   
                   
                   
                 ACAGUGACAGGCGG 
                   
                   
               
               
                   
                   
                   
                 CACAGGCAAGGACG 
                   
                   
               
               
                   
                   
                   
                 GCUACUACGAAGUG 
                   
                   
               
               
                   
                   
                   
                 UCCGUGGACAAGAC 
                   
                   
               
               
                   
                   
                   
                 CAACGGCAAAGUGA 
                   
                   
               
               
                   
                   
                   
                 CUCUGGCUGGCGGA 
                   
                   
               
               
                   
                   
                   
                 GCCACCUCUCCUCU 
                   
                   
               
               
                   
                   
                   
                 UACUGGUGGACUUC 
                   
                   
               
               
                   
                   
                   
                 CUGCCACCGCCACC 
                   
                   
               
               
                   
                   
                   
                 GAGGACGUGAAGAA 
                   
                   
               
               
                   
                   
                   
                 UGUGCAGGUCGCCA 
                   
                   
               
               
                   
                   
                   
                 ACGCCGAUCUGACC 
                   
                   
               
               
                   
                   
                   
                 GAAGCUAAAGCCGC 
                   
                   
               
               
                   
                   
                   
                 UCUGACAGCUGCUG 
                   
                   
               
               
                   
                   
                   
                 GCGUGACCGGAACA 
                   
                   
               
               
                   
                   
                   
                 GCCUCUGUGGUCAA 
                   
                   
               
               
                   
                   
                   
                 GAUGAGCUACACCG 
                   
                   
               
               
                   
                   
                   
                 ACAACAACGGCAAG 
                   
                   
               
               
                   
                   
                   
                 ACCAUCGACGGCGG 
                   
                   
               
               
                   
                   
                   
                 ACUGGCAGUGAAAG 
                   
                   
               
               
                   
                   
                   
                 UGGGCGACGAUUAC 
                   
                   
               
               
                   
                   
                   
                 UACAGCGCCACACA 
                   
                   
               
               
                   
                   
                   
                 GAACAAGGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 GCAUCUCCAUCAAU 
                   
                   
               
               
                   
                   
                   
                 ACCACCAAGUACAC 
                   
                   
               
               
                   
                   
                   
                 CGCCGACGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 CCUCUAAGACCGCU 
                   
                   
               
               
                   
                   
                   
                 CUGAACAAACUCGG 
                   
                   
               
               
                   
                   
                   
                 CGGAGCCGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 AGACCGAGGUGGUG 
                   
                   
               
               
                   
                   
                   
                 UCUAUCGGCGGCAA 
                   
                   
               
               
                   
                   
                   
                 GACAUACGCCGCCU 
                   
                   
               
               
                   
                   
                   
                 CUAAGGCCGAGGGC 
                   
                   
               
               
                   
                   
                   
                 CACAACUUUAAAGC 
                   
                   
               
               
                   
                   
                   
                 CCAGCCUGAUCUGG 
                   
                   
               
               
                   
                   
                   
                 CUGAGGCCGCUGCC 
                   
                   
               
               
                   
                   
                   
                 ACUACCACAGAGAA 
                   
                   
               
               
                   
                   
                   
                 UCCUCUGCAGAAGA 
                   
                   
               
               
                   
                   
                   
                 UCGACGCCGCUCUG 
                   
                   
               
               
                   
                   
                   
                 GCACAAGUGGAUAC 
                   
                   
               
               
                   
                   
                   
                 CCUGAGAAGCGAUC 
                   
                   
               
               
                   
                   
                   
                 UGGGCGCCGUGCAG 
                   
                   
               
               
                   
                   
                   
                 AACAGGUUCAAUAG 
                   
                   
               
               
                   
                   
                   
                 CGCCAUCACCAACC 
                   
                   
               
               
                   
                   
                   
                 UGGGCAACACCGUG 
                   
                   
               
               
                   
                   
                   
                 AACAAUCUGACCAG 
                   
                   
               
               
                   
                   
                   
                 CGCCAGAAGCCGGA 
                   
                   
               
               
                   
                   
                   
                 UCGAGGACAGCGAU 
                   
                   
               
               
                   
                   
                   
                 UAUGCCACAGAGGU 
                   
                   
               
               
                   
                   
                   
                 GUCCAACAUGAGCA 
                   
                   
               
               
                   
                   
                   
                 GAGCCCAGAUCCUG 
                   
                   
               
               
                   
                   
                   
                 CAGCAGGCCGGAAC 
                   
                   
               
               
                   
                   
                   
                 AUCUGUUCUGGCUC 
                   
                   
               
               
                   
                   
                   
                 AGGCCAAUCAGGUG 
                   
                   
               
               
                   
                   
                   
                 CCCCAGAAUGUGCU 
                   
                   
               
               
                   
                   
                   
                 GUCCCUGCUGAGA 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 55 
                 56 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 187 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 56, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_Mig14 
                 MKIQEVKRILTRWQP 
                 AUGAAGAUCCAGGA 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                   
                 SSFTLYREVFTQYGG 
                 GGUGAAGAGAAUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 SINMHPDIVDYFMKR 
                 UCACCCGAUGGCAG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 HNWHFKFFHYKEDD 
                 CCUAGCAGCUUCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 KIKGAYFICNDQNIGI 
                 CCUAUACAGAGAGG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 LTRRTFPLSSDEILIPM 
                 UGUUCACCCAGUAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 APDLRCFLPDRTNRL 
                 GGCGGCAGCAUCAA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 SALHQPQIRNAIWKL 
                 CAUGCACCCGGACA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 ARKKQNCLVKETFSS 
                 UCGUGGACUACUUC 
                   
                 UCCCCC 
               
               
                   
                   
                 KFEKTRRNEYQRFLK 
                 AUGAAGAGACACAA 
                   
                 CAGCCC 
               
               
                   
                   
                 KGGSVKSVADCSSDE 
                 CUGGCACUUCAAGU 
                   
                 CUCCUC 
               
               
                   
                   
                 LTHIFIELFRSRFGNTS 
                 UCUUCCACUACAAG 
                   
                 CCCUUC 
               
               
                   
                   
                 SCYPADNLANFFSQL 
                 GAGGACGACAAGAU 
                   
                 CUGCAC 
               
               
                   
                   
                 HHLLFGHILYIEGIPC 
                 CAAGGGCGCGUAUU 
                   
                 CCGUAC 
               
               
                   
                   
                 AFDIVLKSESQMNVY 
                 UCAUCUGCAACGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 FDVSNGAIKNECRPL 
                 CAGAACAUCGGCAU 
                   
                 GGUCUU 
               
               
                   
                   
                 SPGSILMWLNISRAR 
                 CCUAACACGAAGAA 
                   
                 UGAAUA 
               
               
                   
                   
                 HYCQERQKKLLFSIGI 
                 CCUUCCCUCUGAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 LKPEWEYKRMWSTP 
                 AGCGACGAGAUCCU 
                   
                 GAGUGG 
               
               
                   
                   
                 YFTGKSIC 
                 GAUCCCUAUGGCCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 CUGACCUGAGAUGC 
                   
                   
               
               
                   
                   
                   
                 UUCCUGCCUGACAG 
                   
                   
               
               
                   
                   
                   
                 AACCAACAGACUGA 
                   
                   
               
               
                   
                   
                   
                 GCGCCCUGCACCAG 
                   
                   
               
               
                   
                   
                   
                 CCUCAGAUCAGAAA 
                   
                   
               
               
                   
                   
                   
                 CGCCAUCUGGAAGC 
                   
                   
               
               
                   
                   
                   
                 UGGCCAGAAAGAAG 
                   
                   
               
               
                   
                   
                   
                 CAGAACUGCCUGGU 
                   
                   
               
               
                   
                   
                   
                 GAAGGAAACGUUCA 
                   
                   
               
               
                   
                   
                   
                 GCAGCAAGUUCGAG 
                   
                   
               
               
                   
                   
                   
                 AAGACUCGGCGCAA 
                   
                   
               
               
                   
                   
                   
                 CGAGUACCAGAGAU 
                   
                   
               
               
                   
                   
                   
                 UCCUGAAGAAGGGA 
                   
                   
               
               
                   
                   
                   
                 GGUAGCGUCAAGAG 
                   
                   
               
               
                   
                   
                   
                 CGUGGCCGACUGCA 
                   
                   
               
               
                   
                   
                   
                 GUUCGGACGAACUG 
                   
                   
               
               
                   
                   
                   
                 ACCCACAUCUUCAU 
                   
                   
               
               
                   
                   
                   
                 CGAGCUGUUCCGAU 
                   
                   
               
               
                   
                   
                   
                 CCAGAUUCGGCAAC 
                   
                   
               
               
                   
                   
                   
                 ACCAGCAGCUGCUA 
                   
                   
               
               
                   
                   
                   
                 CCCUGCCGACAACC 
                   
                   
               
               
                   
                   
                   
                 UGGCCAACUUCUUC 
                   
                   
               
               
                   
                   
                   
                 AGCCAGCUGCACCA 
                   
                   
               
               
                   
                   
                   
                 CCUGCUGUUCGGCC 
                   
                   
               
               
                   
                   
                   
                 ACAUCCUGUACAUC 
                   
                   
               
               
                   
                   
                   
                 GAGGGCAUCCCUUG 
                   
                   
               
               
                   
                   
                   
                 CGCCUUCGACAUCG 
                   
                   
               
               
                   
                   
                   
                 UUUUGAAGAGUGA 
                   
                   
               
               
                   
                   
                   
                 GAGCCAGAUGAACG 
                   
                   
               
               
                   
                   
                   
                 UGUACUUCGACGUG 
                   
                   
               
               
                   
                   
                   
                 AGCAACGGCGCCAU 
                   
                   
               
               
                   
                   
                   
                 CAAGAACGAGUGCA 
                   
                   
               
               
                   
                   
                   
                 GACCGUUGUCCCCU 
                   
                   
               
               
                   
                   
                   
                 GGAUCUAUCCUUAU 
                   
                   
               
               
                   
                   
                   
                 GUGGCUGAACAUCA 
                   
                   
               
               
                   
                   
                   
                 GCCGGGCUCGCCAC 
                   
                   
               
               
                   
                   
                   
                 UACUGCCAGGAGAG 
                   
                   
               
               
                   
                   
                   
                 ACAGAAGAAGCUUC 
                   
                   
               
               
                   
                   
                   
                 UCUUCUCAAUCGGA 
                   
                   
               
               
                   
                   
                   
                 AUCUUAAAGCCUGA 
                   
                   
               
               
                   
                   
                   
                 GUGGGAGUACAAGA 
                   
                   
               
               
                   
                   
                   
                 GAAUGUGGAGCACC 
                   
                   
               
               
                   
                   
                   
                 CCUUACUUCACCGG 
                   
                   
               
               
                   
                   
                   
                 CAAGAGCAUCUGC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 57 
                 58 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 188 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 58, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_Mig14_ 
                 MKIQEVKRILTRWQP 
                 AUGAAGAUCCAGGA 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 cHis 
                 SSFTLYREVFTQYGG 
                 GGUGAAGAGAAUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 SINMHPDIVDYFMKR 
                 UCACCCGAUGGCAG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 HNWHFKFFHYKEDD 
                 CCUAGCAGCUUCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 KIKGAYFICNDQNIGI 
                 CCUAUACAGAGAGG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 LTRRTFPLSSDEILIPM 
                 UGUUCACCCAGUAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 APDLRCFLPDRTNRL 
                 GGCGGCAGCAUCAA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 SALHQPQIRNAIWKL 
                 CAUGCACCCGGACA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 ARKKQNCLVKETFSS 
                 UCGUGGACUACUUC 
                   
                 UCCCCC 
               
               
                   
                   
                 KFEKTRRNEYQRFLK 
                 AUGAAGAGACACAA 
                   
                 CAGCCC 
               
               
                   
                   
                 KGGSVKSVADCSSDE 
                 CUGGCACUUCAAGU 
                   
                 CUCCUC 
               
               
                   
                   
                 LTHIFIELFRSRFGNTS 
                 UCUUCCACUACAAG 
                   
                 CCCUUC 
               
               
                   
                   
                 SCYPADNLANFFSQL 
                 GAGGACGACAAGAU 
                   
                 CUGCAC 
               
               
                   
                   
                 HHLLFGHILYIEGIPC 
                 CAAGGGCGCGUAUU 
                   
                 CCGUAC 
               
               
                   
                   
                 AFDIVLKSESQMNVY 
                 UCAUCUGCAACGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 FDVSNGAIKNECRPL 
                 CAGAACAUCGGCAU 
                   
                 GGUCUU 
               
               
                   
                   
                 SPGSILMWLNISRAR 
                 CCUAACACGAAGAA 
                   
                 UGAAUA 
               
               
                   
                   
                 HYCQERQKKLLFSIGI 
                 CCUUCCCUCUGAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 LKPEWEYKRMWSTP 
                 AGCGACGAGAUCCU 
                   
                 GAGUGG 
               
               
                   
                   
                 YFTGKSICHHHHHH 
                 GAUCCCUAUGGCCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 CUGACCUGAGAUGC 
                   
                   
               
               
                   
                   
                   
                 UUCCUGCCUGACAG 
                   
                   
               
               
                   
                   
                   
                 AACCAACAGACUGA 
                   
                   
               
               
                   
                   
                   
                 GCGCCCUGCACCAG 
                   
                   
               
               
                   
                   
                   
                 CCUCAGAUCAGAAA 
                   
                   
               
               
                   
                   
                   
                 CGCCAUCUGGAAGC 
                   
                   
               
               
                   
                   
                   
                 UGGCCAGAAAGAAG 
                   
                   
               
               
                   
                   
                   
                 CAGAACUGCCUGGU 
                   
                   
               
               
                   
                   
                   
                 GAAGGAAACGUUCA 
                   
                   
               
               
                   
                   
                   
                 GCAGCAAGUUCGAG 
                   
                   
               
               
                   
                   
                   
                 AAGACUCGGCGCAA 
                   
                   
               
               
                   
                   
                   
                 CGAGUACCAGAGAU 
                   
                   
               
               
                   
                   
                   
                 UCCUGAAGAAGGGA 
                   
                   
               
               
                   
                   
                   
                 GGUAGCGUCAAGAG 
                   
                   
               
               
                   
                   
                   
                 CGUGGCCGACUGCA 
                   
                   
               
               
                   
                   
                   
                 GUUCGGACGAACUG 
                   
                   
               
               
                   
                   
                   
                 ACCCACAUCUUCAU 
                   
                   
               
               
                   
                   
                   
                 CGAGCUGUUCCGAU 
                   
                   
               
               
                   
                   
                   
                 CCAGAUUCGGCAAC 
                   
                   
               
               
                   
                   
                   
                 ACCAGCAGCUGCUA 
                   
                   
               
               
                   
                   
                   
                 CCCUGCCGACAACC 
                   
                   
               
               
                   
                   
                   
                 UGGCCAACUUCUUC 
                   
                   
               
               
                   
                   
                   
                 AGCCAGCUGCACCA 
                   
                   
               
               
                   
                   
                   
                 CCUGCUGUUCGGCC 
                   
                   
               
               
                   
                   
                   
                 ACAUCCUGUACAUC 
                   
                   
               
               
                   
                   
                   
                 GAGGGCAUCCCUUG 
                   
                   
               
               
                   
                   
                   
                 CGCCUUCGACAUCG 
                   
                   
               
               
                   
                   
                   
                 UUUUGAAGAGUGA 
                   
                   
               
               
                   
                   
                   
                 GAGCCAGAUGAACG 
                   
                   
               
               
                   
                   
                   
                 UGUACUUCGACGUG 
                   
                   
               
               
                   
                   
                   
                 AGCAACGGCGCCAU 
                   
                   
               
               
                   
                   
                   
                 CAAGAACGAGUGCA 
                   
                   
               
               
                   
                   
                   
                 GACCGUUGUCCCCU 
                   
                   
               
               
                   
                   
                   
                 GGAUCUAUCCUUAU 
                   
                   
               
               
                   
                   
                   
                 GUGGCUGAACAUCA 
                   
                   
               
               
                   
                   
                   
                 GCCGGGCUCGCCAC 
                   
                   
               
               
                   
                   
                   
                 UACUGCCAGGAGAG 
                   
                   
               
               
                   
                   
                   
                 ACAGAAGAAGCUUC 
                   
                   
               
               
                   
                   
                   
                 UCUUCUCAAUCGGA 
                   
                   
               
               
                   
                   
                   
                 AUCUUAAAGCCUGA 
                   
                   
               
               
                   
                   
                   
                 GUGGGAGUACAAGA 
                   
                   
               
               
                   
                   
                   
                 GAAUGUGGAGCACC 
                   
                   
               
               
                   
                   
                   
                 CCUUACUUCACCGG 
                   
                   
               
               
                   
                   
                   
                 CAAGAGCAUCUGCC 
                   
                   
               
               
                   
                   
                   
                 ACCACCAUCAUCAC 
                   
                   
               
               
                   
                   
                   
                 CAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 59 
                 60 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 189 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 60, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_Mig14_ 
                 METPAQLLLLLLLWL 
                 AUGGAGACUCCAGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK 
                 PDTTGKIQEVKRILTR 
                 CCAGCUCCUCCUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 WQPSSFTLYREVFTQ 
                 UCCUCUUGCUCUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 YGGSINMHPDIVDYF 
                 UUGCCGGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 MKRHNWHFKFFHYK 
                 CGGCAAGAUCCAGG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 EDDKIKGAYFICNDQ 
                 AGGUGAAGAGAAUC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 NIGILTRRTFPLSSDEI 
                 CUCACCCGAUGGCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LIPMAPDLRCFLPDRT 
                 GCCUAGCAGCUUCA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 NRLSALHQPQIRNAI 
                 CCCUAUACAGAGAG 
                   
                 UCCCCC 
               
               
                   
                   
                 WKLARKKQNCLVKE 
                 GUGUUCACCCAGUA 
                   
                 CAGCCC 
               
               
                   
                   
                 TFSSKFEKTRRNEYQ 
                 CGGCGGCAGCAUCA 
                   
                 CUCCUC 
               
               
                   
                   
                 RFLKKGGSVKSVAD 
                 ACAUGCACCCGGAC 
                   
                 CCCUUC 
               
               
                   
                   
                 CSSDELTHIFIELFRSR 
                 AUCGUGGACUACUU 
                   
                 CUGCAC 
               
               
                   
                   
                 FGNTSSCYPADNLAN 
                 CAUGAAGAGACACA 
                   
                 CCGUAC 
               
               
                   
                   
                 FFSQLHHLLFGHILYI 
                 ACUGGCACUUCAAG 
                   
                 CCCCGU 
               
               
                   
                   
                 EGIPCAFDIVLKSESQ 
                 UUCUUCCACUACAA 
                   
                 GGUCUU 
               
               
                   
                   
                 MNVYFDVSNGAIKN 
                 GGAGGACGACAAGA 
                   
                 UGAAUA 
               
               
                   
                   
                 ECRPLSPGSILMWLNI 
                 UCAAGGGCGCGUAU 
                   
                 AAGUCU 
               
               
                   
                   
                 SRARHYCQERQKKL 
                 UUCAUCUGCAACGA 
                   
                 GAGUGG 
               
               
                   
                   
                 LFSIGILKPEWEYKR 
                 CCAGAACAUCGGCA 
                   
                 GCGGC 
               
               
                   
                   
                 MWSTPYFTGKSIC 
                 UCCUAACACGAAGA 
                   
                   
               
               
                   
                   
                   
                 ACCUUCCCUCUGAG 
                   
                   
               
               
                   
                   
                   
                 CAGCGACGAGAUCC 
                   
                   
               
               
                   
                   
                   
                 UGAUCCCUAUGGCC 
                   
                   
               
               
                   
                   
                   
                 CCUGACCUGAGAUG 
                   
                   
               
               
                   
                   
                   
                 CUUCCUGCCUGACA 
                   
                   
               
               
                   
                   
                   
                 GAACCAACAGACUG 
                   
                   
               
               
                   
                   
                   
                 AGCGCCCUGCACCA 
                   
                   
               
               
                   
                   
                   
                 GCCUCAGAUCAGAA 
                   
                   
               
               
                   
                   
                   
                 ACGCCAUCUGGAAG 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAGAAAGAA 
                   
                   
               
               
                   
                   
                   
                 GCAGAACUGCCUGG 
                   
                   
               
               
                   
                   
                   
                 UGAAGGAAACGUUC 
                   
                   
               
               
                   
                   
                   
                 AGCAGCAAGUUCGA 
                   
                   
               
               
                   
                   
                   
                 GAAGACUCGGCGCA 
                   
                   
               
               
                   
                   
                   
                 ACGAGUACCAGAGA 
                   
                   
               
               
                   
                   
                   
                 UUCCUGAAGAAGGG 
                   
                   
               
               
                   
                   
                   
                 AGGUAGCGUCAAGA 
                   
                   
               
               
                   
                   
                   
                 GCGUGGCCGACUGC 
                   
                   
               
               
                   
                   
                   
                 AGUUCGGACGAACU 
                   
                   
               
               
                   
                   
                   
                 GACCCACAUCUUCA 
                   
                   
               
               
                   
                   
                   
                 UCGAGCUGUUCCGA 
                   
                   
               
               
                   
                   
                   
                 UCCAGAUUCGGCAA 
                   
                   
               
               
                   
                   
                   
                 CACCAGCAGCUGCU 
                   
                   
               
               
                   
                   
                   
                 ACCCUGCCGACAAC 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAACUUCUU 
                   
                   
               
               
                   
                   
                   
                 CAGCCAGCUGCACC 
                   
                   
               
               
                   
                   
                   
                 ACCUGCUGUUCGGC 
                   
                   
               
               
                   
                   
                   
                 CACAUCCUGUACAU 
                   
                   
               
               
                   
                   
                   
                 CGAGGGCAUCCCUU 
                   
                   
               
               
                   
                   
                   
                 GCGCCUUCGACAUC 
                   
                   
               
               
                   
                   
                   
                 GUUUUGAAGAGUG 
                   
                   
               
               
                   
                   
                   
                 AGAGCCAGAUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGUACUUCGACGU 
                   
                   
               
               
                   
                   
                   
                 GAGCAACGGCGCCA 
                   
                   
               
               
                   
                   
                   
                 UCAAGAACGAGUGC 
                   
                   
               
               
                   
                   
                   
                 AGACCGUUGUCCCC 
                   
                   
               
               
                   
                   
                   
                 UGGAUCUAUCCUUA 
                   
                   
               
               
                   
                   
                   
                 UGUGGCUGAACAUC 
                   
                   
               
               
                   
                   
                   
                 AGCCGGGCUCGCCA 
                   
                   
               
               
                   
                   
                   
                 CUACUGCCAGGAGA 
                   
                   
               
               
                   
                   
                   
                 GACAGAAGAAGCUU 
                   
                   
               
               
                   
                   
                   
                 CUCUUCUCAAUCGG 
                   
                   
               
               
                   
                   
                   
                 AAUCUUAAAGCCUG 
                   
                   
               
               
                   
                   
                   
                 AGUGGGAGUACAAG 
                   
                   
               
               
                   
                   
                   
                 AGAAUGUGGAGCAC 
                   
                   
               
               
                   
                   
                   
                 CCCUUACUUCACCG 
                   
                   
               
               
                   
                   
                   
                 GCAAGAGCAUCUGC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 61 
                 62 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 190 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 62, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_Mig14_ 
                 METPAQLLLLLLLWL 
                 AUGGAGACUCCAGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK_cHis 
                 PDTTGKIQEVKRILTR 
                 CCAGCUCCUCCUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 WQPSSFTLYREVFTQ 
                 UCCUCUUGCUCUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 YGGSINMHPDIVDYF 
                 UUGCCGGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 MKRHNWHFKFFHYK 
                 CGGCAAGAUCCAGG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 EDDKIKGAYFICNDQ 
                 AGGUGAAGAGAAUC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 NIGILTRRTFPLSSDEI 
                 CUCACCCGAUGGCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LIPMAPDLRCFLPDRT  
                 GCCUAGCAGCUUCA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 NRLSALHQPQIRNAI 
                 CCCUAUACAGAGAG 
                   
                 UCCCCC 
               
               
                   
                   
                 WKLARKKQNCLVKE 
                 GUGUUCACCCAGUA 
                   
                 CAGCCC 
               
               
                   
                   
                 TFSSKFEKTRRNEYQ 
                 CGGCGGCAGCAUCA 
                   
                 CUCCUC 
               
               
                   
                   
                 RFLKKGGSVKSVAD 
                 ACAUGCACCCGGAC 
                   
                 CCCUUC 
               
               
                   
                   
                 CSSDELTHIFIELFRSR 
                 AUCGUGGACUACUU 
                   
                 CUGCAC 
               
               
                   
                   
                 FGNTSSCYPADNLAN 
                 CAUGAAGAGACACA 
                   
                 CCGUAC 
               
               
                   
                   
                 FFSQLHHLLFGHILYI 
                 ACUGGCACUUCAAG 
                   
                 CCCCGU 
               
               
                   
                   
                 EGIPCAFDIVLKSESQ 
                 UUCUUCCACUACAA 
                   
                 GGUCUU 
               
               
                   
                   
                 MNVYFDVSNGAIKN 
                 GGAGGACGACAAGA 
                   
                 UGAAUA 
               
               
                   
                   
                 ECRPLSPGSILMWLNI 
                 UCAAGGGCGCGUAU 
                   
                 AAGUCU 
               
               
                   
                   
                 SRARHYCQERQKKL 
                 UUCAUCUGCAACGA 
                   
                 GAGUGG 
               
               
                   
                   
                 LFSIGILKPEWEYKR 
                 CCAGAACAUCGGCA 
                   
                 GCGGC 
               
               
                   
                   
                 MWSTPYFTGKSICHH 
                 UCCUAACACGAAGA 
                   
                   
               
               
                   
                   
                 HHHH 
                 ACCUUCCCUCUGAG 
                   
                   
               
               
                   
                   
                   
                 CAGCGACGAGAUCC 
                   
                   
               
               
                   
                   
                   
                 UGAUCCCUAUGGCC 
                   
                   
               
               
                   
                   
                   
                 CCUGACCUGAGAUG 
                   
                   
               
               
                   
                   
                   
                 CUUCCUGCCUGACA 
                   
                   
               
               
                   
                   
                   
                 GAACCAACAGACUG 
                   
                   
               
               
                   
                   
                   
                 AGCGCCCUGCACCA 
                   
                   
               
               
                   
                   
                   
                 GCCUCAGAUCAGAA 
                   
                   
               
               
                   
                   
                   
                 ACGCCAUCUGGAAG 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAGAAAGAA 
                   
                   
               
               
                   
                   
                   
                 GCAGAACUGCCUGG 
                   
                   
               
               
                   
                   
                   
                 UGAAGGAAACGUUC 
                   
                   
               
               
                   
                   
                   
                 AGCAGCAAGUUCGA 
                   
                   
               
               
                   
                   
                   
                 GAAGACUCGGCGCA 
                   
                   
               
               
                   
                   
                   
                 ACGAGUACCAGAGA 
                   
                   
               
               
                   
                   
                   
                 UUCCUGAAGAAGGG 
                   
                   
               
               
                   
                   
                   
                 AGGUAGCGUCAAGA 
                   
                   
               
               
                   
                   
                   
                 GCGUGGCCGACUGC 
                   
                   
               
               
                   
                   
                   
                 AGUUCGGACGAACU 
                   
                   
               
               
                   
                   
                   
                 GACCCACAUCUUCA 
                   
                   
               
               
                   
                   
                   
                 UCGAGCUGUUCCGA 
                   
                   
               
               
                   
                   
                   
                 UCCAGAUUCGGCAA 
                   
                   
               
               
                   
                   
                   
                 CACCAGCAGCUGCU 
                   
                   
               
               
                   
                   
                   
                 ACCCUGCCGACAAC 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAACUUCUU 
                   
                   
               
               
                   
                   
                   
                 CAGCCAGCUGCACC 
                   
                   
               
               
                   
                   
                   
                 ACCUGCUGUUCGGC 
                   
                   
               
               
                   
                   
                   
                 CACAUCCUGUACAU 
                   
                   
               
               
                   
                   
                   
                 CGAGGGCAUCCCUU 
                   
                   
               
               
                   
                   
                   
                 GCGCCUUCGACAUC 
                   
                   
               
               
                   
                   
                   
                 GUUUUGAAGAGUG 
                   
                   
               
               
                   
                   
                   
                 AGAGCCAGAUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGUACUUCGACGU 
                   
                   
               
               
                   
                   
                   
                 GAGCAACGGCGCCA 
                   
                   
               
               
                   
                   
                   
                 UCAAGAACGAGUGC 
                   
                   
               
               
                   
                   
                   
                 AGACCGUUGUCCCC 
                   
                   
               
               
                   
                   
                   
                 UGGAUCUAUCCUUA 
                   
                   
               
               
                   
                   
                   
                 UGUGGCUGAACAUC 
                   
                   
               
               
                   
                   
                   
                 AGCCGGGCUCGCCA 
                   
                   
               
               
                   
                   
                   
                 CUACUGCCAGGAGA 
                   
                   
               
               
                   
                   
                   
                 GACAGAAGAAGCUU 
                   
                   
               
               
                   
                   
                   
                 CUCUUCUCAAUCGG 
                   
                   
               
               
                   
                   
                   
                 AAUCUUAAAGCCUG 
                   
                   
               
               
                   
                   
                   
                 AGUGGGAGUACAAG 
                   
                   
               
               
                   
                   
                   
                 AGAAUGUGGAGCAC 
                   
                   
               
               
                   
                   
                   
                 CCCUUACUUCACCG 
                   
                   
               
               
                   
                   
                   
                 GCAAGAGCAUCUGC 
                   
                   
               
               
                   
                   
                   
                 CACCACCAUCAUCA 
                   
                   
               
               
                   
                   
                   
                 CCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 63 
                 64 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 191 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 64, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_Mig14_ 
                 MKIQEVKRILTRWQP 
                 AUGAAGAUCCAGGA 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM 
                 SSFTLYREVFTQYGG 
                 GGUGAAGAGAAUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 SINMHPDIVDYFMKR 
                 UCACCCGAUGGCAG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 HNWHFKFFHYKEDD 
                 CCUAGCAGCUUCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 KIKGAYFICNDQNIGI 
                 CCUAUACAGAGAGG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 LTRRTFPLSSDEILIPM 
                 UGUUCACCCAGUAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 APDLRCFLPDRTNRL 
                 GGCGGCAGCAUCAA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 SALHQPQIRNAIWKL 
                 CAUGCACCCGGACA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 ARKKQNCLVKETFSS 
                 UCGUGGACUACUUC 
                   
                 UCCCCC 
               
               
                   
                   
                 KFEKTRRNEYQRFLK 
                 AUGAAGAGACACAA 
                   
                 CAGCCC 
               
               
                   
                   
                 KGGSVKSVADCSSDE 
                 CUGGCACUUCAAGU 
                   
                 CUCCUC 
               
               
                   
                   
                 LTHIFIELFRSRFGNT 
                 UCUUCCACUACAAG 
                   
                 CCCUUC 
               
               
                   
                   
                 ASCYPADNLANFFSQ 
                 GAGGACGACAAGAU 
                   
                 CUGCAC 
               
               
                   
                   
                 LHHLLFGHILYIEGIP 
                 CAAGGGCGCGUAUU 
                   
                 CCGUAC 
               
               
                   
                   
                 CAFDIVLKSESQMNV 
                 UCAUCUGCAACGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 YFDVSNGAIKNECRP 
                 CAGAACAUCGGCAU 
                   
                 GGUCUU 
               
               
                   
                   
                 LSPGSILMWLNIARA 
                 CCUAACACGAAGAA 
                   
                 UGAAUA 
               
               
                   
                   
                 RHYCQERQKKLLFSI 
                 CCUUCCCUCUGAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 GILKPEWEYKRMWS 
                 AGCGACGAGAUCCU 
                   
                 GAGUGG 
               
               
                   
                   
                 TPYFTGKSIC 
                 GAUCCCUAUGGCCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 CUGACCUGAGAUGC 
                   
                   
               
               
                   
                   
                   
                 UUCCUGCCUGACAG 
                   
                   
               
               
                   
                   
                   
                 AACCAACAGACUGA 
                   
                   
               
               
                   
                   
                   
                 GCGCCCUGCACCAG 
                   
                   
               
               
                   
                   
                   
                 CCUCAGAUCAGAAA 
                   
                   
               
               
                   
                   
                   
                 CGCCAUCUGGAAGC 
                   
                   
               
               
                   
                   
                   
                 UGGCCAGAAAGAAG 
                   
                   
               
               
                   
                   
                   
                 CAGAACUGCCUGGU 
                   
                   
               
               
                   
                   
                   
                 GAAGGAAACGUUCA 
                   
                   
               
               
                   
                   
                   
                 GCAGCAAGUUCGAG 
                   
                   
               
               
                   
                   
                   
                 AAGACUCGGCGCAA 
                   
                   
               
               
                   
                   
                   
                 CGAGUACCAGAGAU 
                   
                   
               
               
                   
                   
                   
                 UCCUGAAGAAGGGA 
                   
                   
               
               
                   
                   
                   
                 GGUAGCGUCAAGAG 
                   
                   
               
               
                   
                   
                   
                 CGUGGCCGACUGCA 
                   
                   
               
               
                   
                   
                   
                 GUUCGGACGAACUG 
                   
                   
               
               
                   
                   
                   
                 ACCCACAUCUUCAU 
                   
                   
               
               
                   
                   
                   
                 CGAGCUGUUCCGAU 
                   
                   
               
               
                   
                   
                   
                 CCAGAUUCGGCAAC 
                   
                   
               
               
                   
                   
                   
                 ACCGCCAGCUGCUA 
                   
                   
               
               
                   
                   
                   
                 CCCUGCCGACAACC 
                   
                   
               
               
                   
                   
                   
                 UGGCCAACUUCUUC 
                   
                   
               
               
                   
                   
                   
                 AGCCAGCUGCACCA 
                   
                   
               
               
                   
                   
                   
                 CCUGCUGUUCGGCC 
                   
                   
               
               
                   
                   
                   
                 ACAUCCUGUACAUC 
                   
                   
               
               
                   
                   
                   
                 GAGGGCAUCCCUUG 
                   
                   
               
               
                   
                   
                   
                 CGCCUUCGACAUCG 
                   
                   
               
               
                   
                   
                   
                 UUUUGAAGAGUGA 
                   
                   
               
               
                   
                   
                   
                 GAGCCAGAUGAACG 
                   
                   
               
               
                   
                   
                   
                 UGUACUUCGACGUG 
                   
                   
               
               
                   
                   
                   
                 AGCAACGGCGCCAU 
                   
                   
               
               
                   
                   
                   
                 CAAGAACGAGUGCA 
                   
                   
               
               
                   
                   
                   
                 GACCGUUGUCCCCU 
                   
                   
               
               
                   
                   
                   
                 GGAUCUAUCCUUAU 
                   
                   
               
               
                   
                   
                   
                 GUGGCUGAACAUCG 
                   
                   
               
               
                   
                   
                   
                 CCCGGGCUCGCCAC 
                   
                   
               
               
                   
                   
                   
                 UACUGCCAGGAGAG 
                   
                   
               
               
                   
                   
                   
                 ACAGAAGAAGCUUC 
                   
                   
               
               
                   
                   
                   
                 UCUUCUCAAUCGGA 
                   
                   
               
               
                   
                   
                   
                 AUCUUAAAGCCUGA 
                   
                   
               
               
                   
                   
                   
                 GUGGGAGUACAAGA 
                   
                   
               
               
                   
                   
                   
                 GAAUGUGGAGCACC 
                   
                   
               
               
                   
                   
                   
                 CCUUACUUCACCGG 
                   
                   
               
               
                   
                   
                   
                 CAAGAGCAUCUGC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 65 
                 66 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 192 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 66, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_Mig14_ 
                 MKIQEVKRILTRWQP 
                 AUGAAGAUCCAGGA 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_cHi 
                 SSFTLYREVFTQYGG 
                 GGUGAAGAGAAUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 s 
                 SINMHPDIVDYFMKR 
                 UCACCCGAUGGCAG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 HNWHFKFFHYKEDD 
                 CCUAGCAGCUUCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 KIKGAYFICNDQNIGI 
                 CCUAUACAGAGAGG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 LTRRTFPLSSDEILIPM 
                 UGUUCACCCAGUAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 APDLRCFLPDRTNRL 
                 GGCGGCAGCAUCAA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 SALHQPQIRNAIWKL 
                 CAUGCACCCGGACA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 ARKKQNCLVKETFSS 
                 UCGUGGACUACUUC 
                   
                 UCCCCC 
               
               
                   
                   
                 KFEKTRRNEYQRFLK 
                 AUGAAGAGACACAA 
                   
                 CAGCCC 
               
               
                   
                   
                 KGGSVKSVADCSSDE 
                 CUGGCACUUCAAGU 
                   
                 CUCCUC 
               
               
                   
                   
                 LTHIFIELFRSRFGNT 
                 UCUUCCACUACAAG 
                   
                 CCCUUC 
               
               
                   
                   
                 ASCYPADNLANFFSQ 
                 GAGGACGACAAGAU 
                   
                 CUGCAC 
               
               
                   
                   
                 LHHLLFGHILYIEGIP 
                 CAAGGGCGCGUAUU 
                   
                 CCGUAC 
               
               
                   
                   
                 CAFDIVLKSESQMNV 
                 UCAUCUGCAACGAC 
                   
                 CCCCGU 
               
               
                   
                   
                 YFDVSNGAIKNECRP 
                 CAGAACAUCGGCAU 
                   
                 GGUCUU 
               
               
                   
                   
                 LSPGSILMWLNIARA 
                 CCUAACACGAAGAA 
                   
                 UGAAUA 
               
               
                   
                   
                 RHYCQERQKKLLFSI 
                 CCUUCCCUCUGAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 GILKPEWEYKRMWS 
                 AGCGACGAGAUCCU 
                   
                 GAGUGG 
               
               
                   
                   
                 TPYFTGKSICHHHHH 
                 GAUCCCUAUGGCCC 
                   
                 GCGGC 
               
               
                   
                   
                 H 
                 CUGACCUGAGAUGC 
                   
                   
               
               
                   
                   
                   
                 UUCCUGCCUGACAG 
                   
                   
               
               
                   
                   
                   
                 AACCAACAGACUGA 
                   
                   
               
               
                   
                   
                   
                 GCGCCCUGCACCAG 
                   
                   
               
               
                   
                   
                   
                 CCUCAGAUCAGAAA 
                   
                   
               
               
                   
                   
                   
                 CGCCAUCUGGAAGC 
                   
                   
               
               
                   
                   
                   
                 UGGCCAGAAAGAAG 
                   
                   
               
               
                   
                   
                   
                 CAGAACUGCCUGGU 
                   
                   
               
               
                   
                   
                   
                 GAAGGAAACGUUCA 
                   
                   
               
               
                   
                   
                   
                 GCAGCAAGUUCGAG 
                   
                   
               
               
                   
                   
                   
                 AAGACUCGGCGCAA 
                   
                   
               
               
                   
                   
                   
                 CGAGUACCAGAGAU 
                   
                   
               
               
                   
                   
                   
                 UCCUGAAGAAGGGA 
                   
                   
               
               
                   
                   
                   
                 GGUAGCGUCAAGAG 
                   
                   
               
               
                   
                   
                   
                 CGUGGCCGACUGCA 
                   
                   
               
               
                   
                   
                   
                 GUUCGGACGAACUG 
                   
                   
               
               
                   
                   
                   
                 ACCCACAUCUUCAU 
                   
                   
               
               
                   
                   
                   
                 CGAGCUGUUCCGAU 
                   
                   
               
               
                   
                   
                   
                 CCAGAUUCGGCAAC 
                   
                   
               
               
                   
                   
                   
                 ACCGCCAGCUGCUA 
                   
                   
               
               
                   
                   
                   
                 CCCUGCCGACAACC 
                   
                   
               
               
                   
                   
                   
                 UGGCCAACUUCUUC 
                   
                   
               
               
                   
                   
                   
                 AGCCAGCUGCACCA 
                   
                   
               
               
                   
                   
                   
                 CCUGCUGUUCGGCC 
                   
                   
               
               
                   
                   
                   
                 ACAUCCUGUACAUC 
                   
                   
               
               
                   
                   
                   
                 GAGGGCAUCCCUUG 
                   
                   
               
               
                   
                   
                   
                 CGCCUUCGACAUCG 
                   
                   
               
               
                   
                   
                   
                 UUUUGAAGAGUGA 
                   
                   
               
               
                   
                   
                   
                 GAGCCAGAUGAACG 
                   
                   
               
               
                   
                   
                   
                 UGUACUUCGACGUG 
                   
                   
               
               
                   
                   
                   
                 AGCAACGGCGCCAU 
                   
                   
               
               
                   
                   
                   
                 CAAGAACGAGUGCA 
                   
                   
               
               
                   
                   
                   
                 GACCGUUGUCCCCU 
                   
                   
               
               
                   
                   
                   
                 GGAUCUAUCCUUAU 
                   
                   
               
               
                   
                   
                   
                 GUGGCUGAACAUCG 
                   
                   
               
               
                   
                   
                   
                 CCCGGGCUCGCCAC 
                   
                   
               
               
                   
                   
                   
                 UACUGCCAGGAGAG 
                   
                   
               
               
                   
                   
                   
                 ACAGAAGAAGCUUC 
                   
                   
               
               
                   
                   
                   
                 UCUUCUCAAUCGGA 
                   
                   
               
               
                   
                   
                   
                 AUCUUAAAGCCUGA 
                   
                   
               
               
                   
                   
                   
                 GUGGGAGUACAAGA 
                   
                   
               
               
                   
                   
                   
                 GAAUGUGGAGCACC 
                   
                   
               
               
                   
                   
                   
                 CCUUACUUCACCGG 
                   
                   
               
               
                   
                   
                   
                 CAAGAGCAUCUGCC 
                   
                   
               
               
                   
                   
                   
                 ACCACCAUCAUCAC 
                   
                   
               
               
                   
                   
                   
                 CAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 67 
                 68 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 193 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 68, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_Mig14_ 
                 METPAQLLLLLLLWL 
                 AUGGAGACUCCAGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                 PDTTGKIQEVKRILTR 
                 CCAGCUCCUCCUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 K 
                 WQPSSFTLYREVFTQ 
                 UCCUCUUGCUCUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 YGGSINMHPDIVDYF 
                 UUGCCGGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 MKRHNWHFKFFHYK 
                 CGGCAAGAUCCAGG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 EDDKIKGAYFICNDQ 
                 AGGUGAAGAGAAUC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 NIGILTRRTFPLSSDEI 
                 CUCACCCGAUGGCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LIPMAPDLRCFLPDRT 
                 GCCUAGCAGCUUCA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 NRLSALHQPQIRNAI 
                 CCCUAUACAGAGAG 
                   
                 UCCCCC 
               
               
                   
                   
                 WKLARKKQNCLVKE 
                 GUGUUCACCCAGUA 
                   
                 CAGCCC 
               
               
                   
                   
                 TFSSKFEKTRRNEYQ 
                 CGGCGGCAGCAUCA 
                   
                 CUCCUC 
               
               
                   
                   
                 RFLKKGGSVKSVAD 
                 ACAUGCACCCGGAC 
                   
                 CCCUUC 
               
               
                   
                   
                 CSSDELTHIFIELFRSR 
                 AUCGUGGACUACUU 
                   
                 CUGCAC 
               
               
                   
                   
                 FGNTASCYPADNLAN 
                 CAUGAAGAGACACA 
                   
                 CCGUAC 
               
               
                   
                   
                 FFSQLHHLLFGHILYI 
                 ACUGGCACUUCAAG 
                   
                 CCCCGU 
               
               
                   
                   
                 EGIPCAFDIVLKSESQ 
                 UUCUUCCACUACAA 
                   
                 GGUCUU 
               
               
                   
                   
                 MNVYFDVSNGAIKN 
                 GGAGGACGACAAGA 
                   
                 UGAAUA 
               
               
                   
                   
                 ECRPLSPGSILMWLNI 
                 UCAAGGGCGCGUAU 
                   
                 AAGUCU 
               
               
                   
                   
                 ARARHYCQERQKKL 
                 UUCAUCUGCAACGA 
                   
                 GAGUGG 
               
               
                   
                   
                 LFSIGILKPEWEYKR 
                 CCAGAACAUCGGCA 
                   
                 GCGGC 
               
               
                   
                   
                 MWSTPYFTGKSIC 
                 UCCUAACACGAAGA 
                   
                   
               
               
                   
                   
                   
                 ACCUUCCCUCUGAG 
                   
                   
               
               
                   
                   
                   
                 CAGCGACGAGAUCC 
                   
                   
               
               
                   
                   
                   
                 UGAUCCCUAUGGCC 
                   
                   
               
               
                   
                   
                   
                 CCUGACCUGAGAUG 
                   
                   
               
               
                   
                   
                   
                 CUUCCUGCCUGACA 
                   
                   
               
               
                   
                   
                   
                 GAACCAACAGACUG 
                   
                   
               
               
                   
                   
                   
                 AGCGCCCUGCACCA 
                   
                   
               
               
                   
                   
                   
                 GCCUCAGAUCAGAA 
                   
                   
               
               
                   
                   
                   
                 ACGCCAUCUGGAAG 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAGAAAGAA 
                   
                   
               
               
                   
                   
                   
                 GCAGAACUGCCUGG 
                   
                   
               
               
                   
                   
                   
                 UGAAGGAAACGUUC 
                   
                   
               
               
                   
                   
                   
                 AGCAGCAAGUUCGA 
                   
                   
               
               
                   
                   
                   
                 GAAGACUCGGCGCA 
                   
                   
               
               
                   
                   
                   
                 ACGAGUACCAGAGA 
                   
                   
               
               
                   
                   
                   
                 UUCCUGAAGAAGGG 
                   
                   
               
               
                   
                   
                   
                 AGGUAGCGUCAAGA 
                   
                   
               
               
                   
                   
                   
                 GCGUGGCCGACUGC 
                   
                   
               
               
                   
                   
                   
                 AGUUCGGACGAACU 
                   
                   
               
               
                   
                   
                   
                 GACCCACAUCUUCA 
                   
                   
               
               
                   
                   
                   
                 UCGAGCUGUUCCGA 
                   
                   
               
               
                   
                   
                   
                 UCCAGAUUCGGCAA 
                   
                   
               
               
                   
                   
                   
                 CACCGCCAGCUGCU 
                   
                   
               
               
                   
                   
                   
                 ACCCUGCCGACAAC 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAACUUCUU 
                   
                   
               
               
                   
                   
                   
                 CAGCCAGCUGCACC 
                   
                   
               
               
                   
                   
                   
                 ACCUGCUGUUCGGC 
                   
                   
               
               
                   
                   
                   
                 CACAUCCUGUACAU 
                   
                   
               
               
                   
                   
                   
                 CGAGGGCAUCCCUU 
                   
                   
               
               
                   
                   
                   
                 GCGCCUUCGACAUC 
                   
                   
               
               
                   
                   
                   
                 GUUUUGAAGAGUG 
                   
                   
               
               
                   
                   
                   
                 AGAGCCAGAUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGUACUUCGACGU 
                   
                   
               
               
                   
                   
                   
                 GAGCAACGGCGCCA 
                   
                   
               
               
                   
                   
                   
                 UCAAGAACGAGUGC 
                   
                   
               
               
                   
                   
                   
                 AGACCGUUGUCCCC 
                   
                   
               
               
                   
                   
                   
                 UGGAUCUAUCCUUA 
                   
                   
               
               
                   
                   
                   
                 UGUGGCUGAACAUC 
                   
                   
               
               
                   
                   
                   
                 GCCCGGGCUCGCCA 
                   
                   
               
               
                   
                   
                   
                 CUACUGCCAGGAGA 
                   
                   
               
               
                   
                   
                   
                 GACAGAAGAAGCUU 
                   
                   
               
               
                   
                   
                   
                 CUCUUCUCAAUCGG 
                   
                   
               
               
                   
                   
                   
                 AAUCUUAAAGCCUG 
                   
                   
               
               
                   
                   
                   
                 AGUGGGAGUACAAG 
                   
                   
               
               
                   
                   
                   
                 AGAAUGUGGAGCAC 
                   
                   
               
               
                   
                   
                   
                 CCCUUACUUCACCG 
                   
                   
               
               
                   
                   
                   
                 GCAAGAGCAUCUGC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 69 
                 70 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 194 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 70, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_Mig14_ 
                 METPAQLLLLLLLWL 
                 AUGGAGACUCCAGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                 PDTTGKIQEVKRILTR 
                 CCAGCUCCUCCUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 K_cHis 
                 WQPSSFTLYREVFTQ 
                 UCCUCUUGCUCUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 YGGSINMHPDIVDYF 
                 UUGCCGGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 MKRHNWHFKFFHYK 
                 CGGCAAGAUCCAGG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 EDDKIKGAYFICNDQ 
                 AGGUGAAGAGAAUC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 NIGILTRRTFPLSSDEI 
                 CUCACCCGAUGGCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LIPMAPDLRCFLPDRT 
                 GCCUAGCAGCUUCA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 NRLSALHQPQIRNAI 
                 CCCUAUACAGAGAG 
                   
                 UCCCCC 
               
               
                   
                   
                 WKLARKKQNCLVKE 
                 GUGUUCACCCAGUA 
                   
                 CAGCCC 
               
               
                   
                   
                 TFSSKFEKTRRNEYQ 
                 CGGCGGCAGCAUCA 
                   
                 CUCCUC 
               
               
                   
                   
                 RFLKKGGSVKSVAD 
                 ACAUGCACCCGGAC 
                   
                 CCCUUC 
               
               
                   
                   
                 CSSDELTHIFIELFRSR 
                 AUCGUGGACUACUU 
                   
                 CUGCAC 
               
               
                   
                   
                 FGNTASCYPADNLAN 
                 CAUGAAGAGACACA 
                   
                 CCGUAC 
               
               
                   
                   
                 FFSQLHHLLFGHILYI 
                 ACUGGCACUUCAAG 
                   
                 CCCCGU 
               
               
                   
                   
                 EGIPCAFDIVLKSESQ 
                 UUCUUCCACUACAA 
                   
                 GGUCUU 
               
               
                   
                   
                 MNVYFDVSNGAIKN 
                 GGAGGACGACAAGA 
                   
                 UGAAUA 
               
               
                   
                   
                 ECRPLSPGSILMWLNI 
                 UCAAGGGCGCGUAU 
                   
                 AAGUCU 
               
               
                   
                   
                 ARARHYCQERQKKL 
                 UUCAUCUGCAACGA 
                   
                 GAGUGG 
               
               
                   
                   
                 LFSIGILKPEWEYKR 
                 CCAGAACAUCGGCA 
                   
                 GCGGC 
               
               
                   
                   
                 MWSTPYFTGKSICHH 
                 UCCUAACACGAAGA 
                   
                   
               
               
                   
                   
                 HHHH 
                 ACCUUCCCUCUGAG 
                   
                   
               
               
                   
                   
                   
                 CAGCGACGAGAUCC 
                   
                   
               
               
                   
                   
                   
                 UGAUCCCUAUGGCC 
                   
                   
               
               
                   
                   
                   
                 CCUGACCUGAGAUG 
                   
                   
               
               
                   
                   
                   
                 CUUCCUGCCUGACA 
                   
                   
               
               
                   
                   
                   
                 GAACCAACAGACUG 
                   
                   
               
               
                   
                   
                   
                 AGCGCCCUGCACCA 
                   
                   
               
               
                   
                   
                   
                 GCCUCAGAUCAGAA 
                   
                   
               
               
                   
                   
                   
                 ACGCCAUCUGGAAG 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAGAAAGAA 
                   
                   
               
               
                   
                   
                   
                 GCAGAACUGCCUGG 
                   
                   
               
               
                   
                   
                   
                 UGAAGGAAACGUUC 
                   
                   
               
               
                   
                   
                   
                 AGCAGCAAGUUCGA 
                   
                   
               
               
                   
                   
                   
                 GAAGACUCGGCGCA 
                   
                   
               
               
                   
                   
                   
                 ACGAGUACCAGAGA 
                   
                   
               
               
                   
                   
                   
                 UUCCUGAAGAAGGG 
                   
                   
               
               
                   
                   
                   
                 AGGUAGCGUCAAGA 
                   
                   
               
               
                   
                   
                   
                 GCGUGGCCGACUGC 
                   
                   
               
               
                   
                   
                   
                 AGUUCGGACGAACU 
                   
                   
               
               
                   
                   
                   
                 GACCCACAUCUUCA 
                   
                   
               
               
                   
                   
                   
                 UCGAGCUGUUCCGA 
                   
                   
               
               
                   
                   
                   
                 UCCAGAUUCGGCAA 
                   
                   
               
               
                   
                   
                   
                 CACCGCCAGCUGCU 
                   
                   
               
               
                   
                   
                   
                 ACCCUGCCGACAAC 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAACUUCUU 
                   
                   
               
               
                   
                   
                   
                 CAGCCAGCUGCACC 
                   
                   
               
               
                   
                   
                   
                 ACCUGCUGUUCGGC 
                   
                   
               
               
                   
                   
                   
                 CACAUCCUGUACAU 
                   
                   
               
               
                   
                   
                   
                 CGAGGGCAUCCCUU 
                   
                   
               
               
                   
                   
                   
                 GCGCCUUCGACAUC 
                   
                   
               
               
                   
                   
                   
                 GUUUUGAAGAGUG 
                   
                   
               
               
                   
                   
                   
                 AGAGCCAGAUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGUACUUCGACGU 
                   
                   
               
               
                   
                   
                   
                 GAGCAACGGCGCCA 
                   
                   
               
               
                   
                   
                   
                 UCAAGAACGAGUGC 
                   
                   
               
               
                   
                   
                   
                 AGACCGUUGUCCCC 
                   
                   
               
               
                   
                   
                   
                 UGGAUCUAUCCUUA 
                   
                   
               
               
                   
                   
                   
                 UGUGGCUGAACAUC 
                   
                   
               
               
                   
                   
                   
                 GCCCGGGCUCGCCA 
                   
                   
               
               
                   
                   
                   
                 CUACUGCCAGGAGA 
                   
                   
               
               
                   
                   
                   
                 GACAGAAGAAGCUU 
                   
                   
               
               
                   
                   
                   
                 CUCUUCUCAAUCGG 
                   
                   
               
               
                   
                   
                   
                 AAUCUUAAAGCCUG 
                   
                   
               
               
                   
                   
                   
                 AGUGGGAGUACAAG 
                   
                   
               
               
                   
                   
                   
                 AGAAUGUGGAGCAC 
                   
                   
               
               
                   
                   
                   
                 CCCUUACUUCACCG 
                   
                   
               
               
                   
                   
                   
                 GCAAGAGCAUCUGC 
                   
                   
               
               
                   
                   
                   
                 CACCACCAUCAUCA 
                   
                   
               
               
                   
                   
                   
                 CCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 71 
                 72 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 195 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 72, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_iroN_n 
                 MGLQTTKWPSHGAF 
                 AUGGGCCUGCAGAC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 FLRT2_c 
                 FLKSWLIISLGLYSQV 
                 CACAAAGUGGCCUU 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 His 
                 SKLLAAESTDDNGET 
                 CUCACGGCGCAUUC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 IVVESTAEQVLKQQP 
                 UUUCUGAAGUCCUG 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 GVSIITRDDIQKNPPV  
                 GCUGAUCAUCUCCC 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NDLADIIRKMPGVNL 
                 UGGGCCUGUACAGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 TSNSASGTRGNNRQI 
                 CAGGUGUCCAAACU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 DIRGMGPENTLVLID 
                 GCUGGCCGCCGAGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 GVPVTSRNSVRYSW 
                 GCACCGACGAUAAC 
                   
                 UCCCCC 
               
               
                   
                   
                 RGERDTRGDTNWVP 
                 GGCGAGACAAUCGU 
                   
                 CAGCCC 
               
               
                   
                   
                 PEMVERIEMIRGPAA 
                 GGUGGAAAGCACCG 
                   
                 CUCCUC 
               
               
                   
                   
                 ARYGSGAAGGVVNII 
                 CCGAACAGGUGCUG 
                   
                 CCCUUC 
               
               
                   
                   
                 TKRPTNDWHGSLSLY 
                 AAACAGCAGCCUGG 
                   
                 CUGCAC 
               
               
                   
                   
                 TNYPESSKEGDTRRG 
                 CGUGUCCAUCAUCA 
                   
                 CCGUAC 
               
               
                   
                   
                 NFSLSGPLAGDTLTM 
                 CCCGGGACGACAUC 
                   
                 CCCCGU 
               
               
                   
                   
                 RLYGNLNRTDADSW 
                 CAGAAGAACCCUCC 
                   
                 GGUCUU 
               
               
                   
                   
                 DINSSAGTKNAAGRE 
                 AGUCAACGACCUGG 
                   
                 UGAAUA 
               
               
                   
                   
                 GVTNKDINSVFSWK 
                 CCGACAUCAUCAGA 
                   
                 AAGUCU 
               
               
                   
                   
                 MTPQQILDFEAGYSR 
                 AAGAUGCCCGGCGU 
                   
                 GAGUGG 
               
               
                   
                   
                 QGNIYAGDTQNSNSN 
                 GAACCUGACCAGCA 
                   
                 GCGGC 
               
               
                   
                   
                 AVTKSLAQSGRETNR 
                 AUAGCGCCUCUGGC 
                   
                   
               
               
                   
                   
                 LYRQNYGLTHNGIW 
                 ACCCGGGGCAACAA 
                   
                   
               
               
                   
                   
                 GWGQSRLGFYYEKT 
                 CAGACAGAUCGACA 
                   
                   
               
               
                   
                   
                 DNTRMNEGLSGGGE 
                 UCAGAGGCAUGGGC 
                   
                   
               
               
                   
                   
                 GRITNDQTFTTNRLTS 
                 CCCGAGAAUACCCU 
                   
                   
               
               
                   
                   
                 YRTSGEVNVPVIWLF 
                 GGUGCUGAUUGAUG 
                   
                   
               
               
                   
                   
                 EQTLTVGAEWNRDE 
                 GCGUGCCCGUGACC 
                   
                   
               
               
                   
                   
                 LNDPSSTSLTVKDSNI 
                 AGCAGAAACAGCGU 
                   
                   
               
               
                   
                   
                 AGIPGSAANRSSKNK 
                 GCGGUAUUCUUGGA 
                   
                   
               
               
                   
                   
                 SEISALYVEDNIEPMA 
                 GAGGCGAGAGAGAC 
                   
                   
               
               
                   
                   
                 GTNIIPGLRFDYLSES 
                 ACCAGAGGCGACAC 
                   
                   
               
               
                   
                   
                 GSNFSPSLNLSQELGE 
                 CAAUUGGGUGCCAC 
                   
                   
               
               
                   
                   
                 FVKVKAGIARAFKAP 
                 CUGAGAUGGUGGAA 
                   
                   
               
               
                   
                   
                 NLYQTSEGYLLYSKG 
                 CGGAUCGAGAUGAU 
                   
                   
               
               
                   
                   
                 NGCPKDITSGGCYLV 
                 UAGAGGCCCCGCUG 
                   
                   
               
               
                   
                   
                 GNKNLDPEISINKEIG 
                 CCGCCAGAUAUGGA 
                   
                   
               
               
                   
                   
                 LEFTVDDYHASVTYF 
                 UCUGGUGCUGCUGG 
                   
                   
               
               
                   
                   
                 RNDYQNKIVAGDQII 
                 CGGCGUGGUCAAUA 
                   
                   
               
               
                   
                   
                 GRSASGAYVLQWQN 
                 UCAUCACCAAGAGG 
                   
                   
               
               
                   
                   
                 GGKALIEGIEASMAV 
                 CCCACCAACGACUG 
                   
                   
               
               
                   
                   
                 PLMPDRLNWNTNAT 
                 GCACGGCAGCCUGA 
                   
                   
               
               
                   
                   
                 YMITSEQKDTGNPLSI 
                 GCCUGUAUACAAAC 
                   
                   
               
               
                   
                   
                 IPKYTVNTFLDWTIT 
                 UACCCCGAGAGCAG 
                   
                   
               
               
                   
                   
                 NALSANVNWTLYGK 
                 CAAAGAGGGCGAUA 
                   
                   
               
               
                   
                   
                 QKPRTHAESRSEETK 
                 CCAGAAGAGGCAAC 
                   
                   
               
               
                   
                   
                 GLSGKALGAYSLVG 
                 UUUAGCCUGUCUGG 
                   
                   
               
               
                   
                   
                 ANVNYDINKNLRLN 
                 CCCUCUGGCCGGCG 
                   
                   
               
               
                   
                   
                 VGISNIFDKQIYRSAE 
                 AUACCCUGACAAUG 
                   
                   
               
               
                   
                   
                 GANTYNEPGRAYYA 
                 AGACUGUACGGCAA 
                   
                   
               
               
                   
                   
                 GVTASFHHHHHH 
                 CCUGAACCGGACCG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGAUAGCUGG 
                   
                   
               
               
                   
                   
                   
                 GACAUCAAUAGCAG 
                   
                   
               
               
                   
                   
                   
                 CGCCGGCACCAAGA 
                   
                   
               
               
                   
                   
                   
                 AUGCCGCCGGAAGA 
                   
                   
               
               
                   
                   
                   
                 GAAGGCGUGACCAA 
                   
                   
               
               
                   
                   
                   
                 CAAGGACAUCAACA 
                   
                   
               
               
                   
                   
                   
                 GCGUGUUCAGCUGG 
                   
                   
               
               
                   
                   
                   
                 AAGAUGACCCCUCA 
                   
                   
               
               
                   
                   
                   
                 GCAGAUCCUGGAUU 
                   
                   
               
               
                   
                   
                   
                 UCGAGGCCGGCUAU 
                   
                   
               
               
                   
                   
                   
                 AGCAGACAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUAUGCCGGCG 
                   
                   
               
               
                   
                   
                   
                 ACACCCAGAACAGC 
                   
                   
               
               
                   
                   
                   
                 AACAGCAACGCCGU 
                   
                   
               
               
                   
                   
                   
                 GACCAAGUCUCUGG 
                   
                   
               
               
                   
                   
                   
                 CCCAGUCUGGCAGA 
                   
                   
               
               
                   
                   
                   
                 GAGACAAACAGGCU 
                   
                   
               
               
                   
                   
                   
                 GUACCGGCAGAACU 
                   
                   
               
               
                   
                   
                   
                 ACGGCCUGACACAC 
                   
                   
               
               
                   
                   
                   
                 AAUGGCAUCUGGGG 
                   
                   
               
               
                   
                   
                   
                 CUGGGGACAGUCUA 
                   
                   
               
               
                   
                   
                   
                 GGCUGGGCUUCUAC 
                   
                   
               
               
                   
                   
                   
                 UACGAGAAGACCGA 
                   
                   
               
               
                   
                   
                   
                 CAACACCCGGAUGA 
                   
                   
               
               
                   
                   
                   
                 ACGAGGGACUUUCU 
                   
                   
               
               
                   
                   
                   
                 GGCGGCGGAGAGGG 
                   
                   
               
               
                   
                   
                   
                 CAGAAUCACCAACG 
                   
                   
               
               
                   
                   
                   
                 AUCAGACCUUCACC 
                   
                   
               
               
                   
                   
                   
                 ACCAACCGGCUGAC 
                   
                   
               
               
                   
                   
                   
                 CAGCUACAGAACCA 
                   
                   
               
               
                   
                   
                   
                 GCGGCGAAGUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGCCAGUGAUCUG 
                   
                   
               
               
                   
                   
                   
                 GCUGUUCGAGCAGA 
                   
                   
               
               
                   
                   
                   
                 CCCUGACAGUGGGC 
                   
                   
               
               
                   
                   
                   
                 GCCGAGUGGAAUAG 
                   
                   
               
               
                   
                   
                   
                 AGAUGAGCUGAACG 
                   
                   
               
               
                   
                   
                   
                 ACCCCAGCUCCACC 
                   
                   
               
               
                   
                   
                   
                 AGCCUGACCGUGAA 
                   
                   
               
               
                   
                   
                   
                 GGACUCUAAUAUCG 
                   
                   
               
               
                   
                   
                   
                 CUGGCAUCCCUGGC 
                   
                   
               
               
                   
                   
                   
                 AGCGCCGCCAACAG 
                   
                   
               
               
                   
                   
                   
                 AAGCAGCAAGAACA 
                   
                   
               
               
                   
                   
                   
                 AGAGCGAGAUCAGC 
                   
                   
               
               
                   
                   
                   
                 GCCCUGUACGUCGA 
                   
                   
               
               
                   
                   
                   
                 GGACAACAUCGAAC 
                   
                   
               
               
                   
                   
                   
                 CUAUGGCCGGCACA 
                   
                   
               
               
                   
                   
                   
                 AACAUCAUCCCCGG 
                   
                   
               
               
                   
                   
                   
                 CCUGAGAUUCGACU 
                   
                   
               
               
                   
                   
                   
                 ACCUGAGCGAGAGC 
                   
                   
               
               
                   
                   
                   
                 GGCAGCAACUUCAG 
                   
                   
               
               
                   
                   
                   
                 CCCCAGCCUGAAUC 
                   
                   
               
               
                   
                   
                   
                 UGUCUCAAGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GGCGAGUUCGUGAA 
                   
                   
               
               
                   
                   
                   
                 AGUGAAGGCCGGAA 
                   
                   
               
               
                   
                   
                   
                 UCGCCAGAGCCUUC 
                   
                   
               
               
                   
                   
                   
                 AAGGCCCCUAAUCU 
                   
                   
               
               
                   
                   
                   
                 GUACCAGACCAGCG 
                   
                   
               
               
                   
                   
                   
                 AGGGCUACCUGCUG 
                   
                   
               
               
                   
                   
                   
                 UACUCCAAAGGCAA 
                   
                   
               
               
                   
                   
                   
                 CGGCUGCCCCAAGG 
                   
                   
               
               
                   
                   
                   
                 AUAUCACAAGCGGC 
                   
                   
               
               
                   
                   
                   
                 GGCUGUUACCUCGU 
                   
                   
               
               
                   
                   
                   
                 GGGCAACAAGAACC 
                   
                   
               
               
                   
                   
                   
                 UGGAUCCUGAGAUC 
                   
                   
               
               
                   
                   
                   
                 AGCAUCAACAAAGA 
                   
                   
               
               
                   
                   
                   
                 GAUCGGCCUGGAAU 
                   
                   
               
               
                   
                   
                   
                 UCACCGUGGACGAC 
                   
                   
               
               
                   
                   
                   
                 UACCACGCCAGCGU 
                   
                   
               
               
                   
                   
                   
                 GACCUACUUCCGGA 
                   
                   
               
               
                   
                   
                   
                 ACGAUUACCAGAAC 
                   
                   
               
               
                   
                   
                   
                 AAGAUCGUGGCCGG 
                   
                   
               
               
                   
                   
                   
                 GGACCAGAUCAUCG 
                   
                   
               
               
                   
                   
                   
                 GCAGAAGUGCUAGC 
                   
                   
               
               
                   
                   
                   
                 GGAGCCUACGUGCU 
                   
                   
               
               
                   
                   
                   
                 GCAAUGGCAGAAUG 
                   
                   
               
               
                   
                   
                   
                 GCGGAAAGGCCCUG 
                   
                   
               
               
                   
                   
                   
                 AUCGAGGGAAUCGA 
                   
                   
               
               
                   
                   
                   
                 GGCUUCUAUGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGCCACUGAUGCCC 
                   
                   
               
               
                   
                   
                   
                 GACAGACUGAACUG 
                   
                   
               
               
                   
                   
                   
                 GAACACCAACGCCA 
                   
                   
               
               
                   
                   
                   
                 CCUACAUGAUCACC 
                   
                   
               
               
                   
                   
                   
                 AGCGAGCAGAAGGA 
                   
                   
               
               
                   
                   
                   
                 CACCGGCAAUCCUC 
                   
                   
               
               
                   
                   
                   
                 UGAGCAUCAUCCCU 
                   
                   
               
               
                   
                   
                   
                 AAGUAUACCGUGAA 
                   
                   
               
               
                   
                   
                   
                 CACCUUCCUGGACU 
                   
                   
               
               
                   
                   
                   
                 GGACCAUCACAAAC 
                   
                   
               
               
                   
                   
                   
                 GCCCUGAGCGCCAA 
                   
                   
               
               
                   
                   
                   
                 CGUGAACUGGACCC 
                   
                   
               
               
                   
                   
                   
                 UGUAUGGCAAGCAG 
                   
                   
               
               
                   
                   
                   
                 AAGCCACGGACACA 
                   
                   
               
               
                   
                   
                   
                 CGCCGAGUCCAGAA 
                   
                   
               
               
                   
                   
                   
                 GCGAGGAAACAAAG 
                   
                   
               
               
                   
                   
                   
                 GGCCUGAGCGGCAA 
                   
                   
               
               
                   
                   
                   
                 AGCCCUGGGCGCCU 
                   
                   
               
               
                   
                   
                   
                 AUUCUCUUGUGGGC 
                   
                   
               
               
                   
                   
                   
                 GCCAAUGUGAAUUA 
                   
                   
               
               
                   
                   
                   
                 CGACAUUAACAAGA 
                   
                   
               
               
                   
                   
                   
                 AUCUGCGGCUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGGGCAUCAGCAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUUCGACAAGC 
                   
                   
               
               
                   
                   
                   
                 AGAUCUACAGAAGC 
                   
                   
               
               
                   
                   
                   
                 GCCGAGGGCGCCAA 
                   
                   
               
               
                   
                   
                   
                 CACCUACAAUGAAC 
                   
                   
               
               
                   
                   
                   
                 CUGGCAGAGCCUAC 
                   
                   
               
               
                   
                   
                   
                 UAUGCUGGCGUGAC 
                   
                   
               
               
                   
                   
                   
                 CGCCAGCUUCCAUC 
                   
                   
               
               
                   
                   
                   
                 ACCACCAUCAUCAU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 73 
                 74 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 196 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 74, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_iroN_n 
                 MGLQTTKWPSHGAF 
                 AUGGGCCUGCAGAC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 FLRT2 
                 FLKSWLIISLGLYSQV 
                 CACAAAGUGGCCUU 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 SKLLAAESTDDNGET 
                 CUCACGGCGCAUUC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 IVVESTAEQVLKQQP 
                 UUUCUGAAGUCCUG 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 GVSIITRDDIQKNPPV 
                 GCUGAUCAUCUCCC 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NDLADIIRKMPGVNL 
                 UGGGCCUGUACAGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 TSNSASGTRGNNRQI 
                 CAGGUGUCCAAACU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 GVPVTSRNSVRYSW 
                 GCACCGACGAUAAC 
                   
                 UCCCCC 
               
               
                   
                   
                 RGERDTRGDTNWVP 
                 GGCGAGACAAUCGU 
                   
                 CAGCCC 
               
               
                   
                   
                 PEMVERIEMIRGPAA 
                 GGUGGAAAGCACCG 
                   
                 CUCCUC 
               
               
                   
                   
                 ARYGSGAAGGVVNII 
                 CCGAACAGGUGCUG 
                   
                 CCCUUC 
               
               
                   
                   
                 TKRPTNDWHGSLSLY 
                 AAACAGCAGCCUGG 
                   
                 CUGCAC 
               
               
                   
                   
                 TNYPESSKEGDTRRG 
                 CGUGUCCAUCAUCA 
                   
                 CCGUAC 
               
               
                   
                   
                 NFSLSGPLAGDTLTM 
                 CCCGGGACGACAUC 
                   
                 CCCCGU 
               
               
                   
                   
                 RLYGNLNRTDADSW 
                 CAGAAGAACCCUCC 
                   
                 GGUCUU 
               
               
                   
                   
                 DINSSAGTKNAAGRE 
                 AGUCAACGACCUGG 
                   
                 UGAAUA 
               
               
                   
                   
                 GVTNKDINSVFSWK 
                 CCGACAUCAUCAGA 
                   
                 AAGUCU 
               
               
                   
                   
                 MTPQQILDFEAGYSR 
                 AAGAUGCCCGGCGU 
                   
                 GAGUGG 
               
               
                   
                   
                 QGNIYAGDTQNSNSN 
                 GAACCUGACCAGCA 
                   
                 GCGGC 
               
               
                   
                   
                 AVTKSLAQSGRETNR 
                 AUAGCGCCUCUGGC 
                   
                   
               
               
                   
                   
                 LYRQNYGLTHNGIW 
                 ACCCGGGGCAACAA 
                   
                   
               
               
                   
                   
                 GWGQSRLGFYYEKT 
                 CAGACAGAUCGACA 
                   
                   
               
               
                   
                   
                 DNTRMNEGLSGGGE 
                 UCAGAGGCAUGGGC 
                   
                   
               
               
                   
                   
                 GRITNDQTFTTNRLTS 
                 CCCGAGAAUACCCU 
                   
                   
               
               
                   
                   
                 YRTSGEVNVPVIWLF 
                 GGUGCUGAUUGAUG 
                   
                   
               
               
                   
                   
                 EQTLTVGAEWNRDE 
                 GCGUGCCCGUGACC 
                   
                   
               
               
                   
                   
                 LNDPSSTSLTVKDSNI 
                 AGCAGAAACAGCGU 
                   
                   
               
               
                   
                   
                 AGIPGSAANRSSKNK 
                 GCGGUAUUCUUGGA 
                   
                   
               
               
                   
                   
                 SEISALYVEDNIEPMA 
                 GAGGCGAGAGAGAC 
                   
                   
               
               
                   
                   
                 GTNIIPGLRFDYLSES 
                 ACCAGAGGCGACAC 
                   
                   
               
               
                   
                   
                 GSNFSPSLNLSQELGE 
                 CAAUUGGGUGCCAC 
                   
                   
               
               
                   
                   
                 FVKVKAGIARAFKAP 
                 CUGAGAUGGUGGAA 
                   
                   
               
               
                   
                   
                 NLYQTSEGYLLYSKG 
                 CGGAUCGAGAUGAU 
                   
                   
               
               
                   
                   
                 NGCPKDITSGGCYLV 
                 UAGAGGCCCCGCUG 
                   
                   
               
               
                   
                   
                 GNKNLDPEISINKEIG 
                 CCGCCAGAUAUGGA 
                   
                   
               
               
                   
                   
                 LEFTVDDYHASVTYF 
                 UCUGGUGCUGCUGG 
                   
                   
               
               
                   
                   
                 RNDYQNKIVAGDQII 
                 CGGCGUGGUCAAUA 
                   
                   
               
               
                   
                   
                 GRSASGAYVLQWQN 
                 UCAUCACCAAGAGG 
                   
                   
               
               
                   
                   
                 GGKALIEGIEASMAV 
                 CCCACCAACGACUG 
                   
                   
               
               
                   
                   
                 PLMPDRLNWNTNAT 
                 GCACGGCAGCCUGA 
                   
                   
               
               
                   
                   
                 YMITSEQKDTGNPLSI 
                 GCCUGUAUACAAAC 
                   
                   
               
               
                   
                   
                 IPKYTVNTFLDWTIT 
                 UACCCCGAGAGCAG 
                   
                   
               
               
                   
                   
                 NALSANVNWTLYGK 
                 CAAAGAGGGCGAUA 
                   
                   
               
               
                   
                   
                 QKPRTHAESRSEETK 
                 CCAGAAGAGGCAAC 
                   
                   
               
               
                   
                   
                 GLSGKALGAYSLVG 
                 UUUAGCCUGUCUGG 
                   
                   
               
               
                   
                   
                 ANVNYDINKNLRLN 
                 CCCUCUGGCCGGCG 
                   
                   
               
               
                   
                   
                 VGISNIFDKQIYRSAE 
                 AUACCCUGACAAUG 
                   
                   
               
               
                   
                   
                 GANTYNEPGRAYYA 
                 AGACUGUACGGCAA 
                   
                   
               
               
                   
                   
                 GVTASF 
                 CCUGAACCGGACCG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGAUAGCUGG 
                   
                   
               
               
                   
                   
                   
                 GACAUCAAUAGCAG 
                   
                   
               
               
                   
                   
                   
                 CGCCGGCACCAAGA 
                   
                   
               
               
                   
                   
                   
                 AUGCCGCCGGAAGA 
                   
                   
               
               
                   
                   
                   
                 GAAGGCGUGACCAA 
                   
                   
               
               
                   
                   
                   
                 CAAGGACAUCAACA 
                   
                   
               
               
                   
                   
                   
                 GCGUGUUCAGCUGG 
                   
                   
               
               
                   
                   
                   
                 AAGAUGACCCCUCA 
                   
                   
               
               
                   
                   
                   
                 GCAGAUCCUGGAUU 
                   
                   
               
               
                   
                   
                   
                 UCGAGGCCGGCUAU 
                   
                   
               
               
                   
                   
                   
                 AGCAGACAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUAUGCCGGCG 
                   
                   
               
               
                   
                   
                   
                 ACACCCAGAACAGC 
                   
                   
               
               
                   
                   
                   
                 AACAGCAACGCCGU 
                   
                   
               
               
                   
                   
                   
                 GACCAAGUCUCUGG 
                   
                   
               
               
                   
                   
                   
                 CCCAGUCUGGCAGA 
                   
                   
               
               
                   
                   
                   
                 GAGACAAACAGGCU 
                   
                   
               
               
                   
                   
                   
                 GUACCGGCAGAACU 
                   
                   
               
               
                   
                   
                   
                 ACGGCCUGACACAC 
                   
                   
               
               
                   
                   
                   
                 AAUGGCAUCUGGGG 
                   
                   
               
               
                   
                   
                   
                 CUGGGGACAGUCUA 
                   
                   
               
               
                   
                   
                   
                 GGCUGGGCUUCUAC 
                   
                   
               
               
                   
                   
                   
                 UACGAGAAGACCGA 
                   
                   
               
               
                   
                   
                   
                 CAACACCCGGAUGA 
                   
                   
               
               
                   
                   
                   
                 ACGAGGGACUUUCU 
                   
                   
               
               
                   
                   
                   
                 GGCGGCGGAGAGGG 
                   
                   
               
               
                   
                   
                   
                 CAGAAUCACCAACG 
                   
                   
               
               
                   
                   
                   
                 AUCAGACCUUCACC 
                   
                   
               
               
                   
                   
                   
                 ACCAACCGGCUGAC 
                   
                   
               
               
                   
                   
                   
                 CAGCUACAGAACCA 
                   
                   
               
               
                   
                   
                   
                 GCGGCGAAGUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGCCAGUGAUCUG 
                   
                   
               
               
                   
                   
                   
                 GCUGUUCGAGCAGA 
                   
                   
               
               
                   
                   
                   
                 CCCUGACAGUGGGC 
                   
                   
               
               
                   
                   
                   
                 GCCGAGUGGAAUAG 
                   
                   
               
               
                   
                   
                   
                 AGAUGAGCUGAACG 
                   
                   
               
               
                   
                   
                   
                 ACCCCAGCUCCACC 
                   
                   
               
               
                   
                   
                   
                 AGCCUGACCGUGAA 
                   
                   
               
               
                   
                   
                   
                 GGACUCUAAUAUCG 
                   
                   
               
               
                   
                   
                   
                 CUGGCAUCCCUGGC 
                   
                   
               
               
                   
                   
                   
                 AGCGCCGCCAACAG 
                   
                   
               
               
                   
                   
                   
                 AAGCAGCAAGAACA 
                   
                   
               
               
                   
                   
                   
                 AGAGCGAGAUCAGC 
                   
                   
               
               
                   
                   
                   
                 GCCCUGUACGUCGA 
                   
                   
               
               
                   
                   
                   
                 GGACAACAUCGAAC 
                   
                   
               
               
                   
                   
                   
                 CUAUGGCCGGCACA 
                   
                   
               
               
                   
                   
                   
                 AACAUCAUCCCCGG 
                   
                   
               
               
                   
                   
                   
                 CCUGAGAUUCGACU 
                   
                   
               
               
                   
                   
                   
                 ACCUGAGCGAGAGC 
                   
                   
               
               
                   
                   
                   
                 GGCAGCAACUUCAG 
                   
                   
               
               
                   
                   
                   
                 CCCCAGCCUGAAUC 
                   
                   
               
               
                   
                   
                   
                 UGUCUCAAGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GGCGAGUUCGUGAA 
                   
                   
               
               
                   
                   
                   
                 AGUGAAGGCCGGAA 
                   
                   
               
               
                   
                   
                   
                 UCGCCAGAGCCUUC 
                   
                   
               
               
                   
                   
                   
                 AAGGCCCCUAAUCU 
                   
                   
               
               
                   
                   
                   
                 GUACCAGACCAGCG 
                   
                   
               
               
                   
                   
                   
                 AGGGCUACCUGCUG 
                   
                   
               
               
                   
                   
                   
                 UACUCCAAAGGCAA 
                   
                   
               
               
                   
                   
                   
                 CGGCUGCCCCAAGG 
                   
                   
               
               
                   
                   
                   
                 AUAUCACAAGCGGC 
                   
                   
               
               
                   
                   
                   
                 GGCUGUUACCUCGU 
                   
                   
               
               
                   
                   
                   
                 GGGCAACAAGAACC 
                   
                   
               
               
                   
                   
                   
                 UGGAUCCUGAGAUC 
                   
                   
               
               
                   
                   
                   
                 AGCAUCAACAAAGA 
                   
                   
               
               
                   
                   
                   
                 GAUCGGCCUGGAAU 
                   
                   
               
               
                   
                   
                   
                 UCACCGUGGACGAC 
                   
                   
               
               
                   
                   
                   
                 UACCACGCCAGCGU 
                   
                   
               
               
                   
                   
                   
                 GACCUACUUCCGGA 
                   
                   
               
               
                   
                   
                   
                 ACGAUUACCAGAAC 
                   
                   
               
               
                   
                   
                   
                 AAGAUCGUGGCCGG 
                   
                   
               
               
                   
                   
                   
                 GGACCAGAUCAUCG 
                   
                   
               
               
                   
                   
                   
                 GCAGAAGUGCUAGC 
                   
                   
               
               
                   
                   
                   
                 GGAGCCUACGUGCU 
                   
                   
               
               
                   
                   
                   
                 GCAAUGGCAGAAUG 
                   
                   
               
               
                   
                   
                   
                 GCGGAAAGGCCCUG 
                   
                   
               
               
                   
                   
                   
                 AUCGAGGGAAUCGA 
                   
                   
               
               
                   
                   
                   
                 GGCUUCUAUGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGCCACUGAUGCCC 
                   
                   
               
               
                   
                   
                   
                 GACAGACUGAACUG 
                   
                   
               
               
                   
                   
                   
                 GAACACCAACGCCA 
                   
                   
               
               
                   
                   
                   
                 CCUACAUGAUCACC 
                   
                   
               
               
                   
                   
                   
                 AGCGAGCAGAAGGA 
                   
                   
               
               
                   
                   
                   
                 CACCGGCAAUCCUC 
                   
                   
               
               
                   
                   
                   
                 UGAGCAUCAUCCCU 
                   
                   
               
               
                   
                   
                   
                 AAGUAUACCGUGAA 
                   
                   
               
               
                   
                   
                   
                 CACCUUCCUGGACU 
                   
                   
               
               
                   
                   
                   
                 GGACCAUCACAAAC 
                   
                   
               
               
                   
                   
                   
                 GCCCUGAGCGCCAA 
                   
                   
               
               
                   
                   
                   
                 CGUGAACUGGACCC 
                   
                   
               
               
                   
                   
                   
                 UGUAUGGCAAGCAG 
                   
                   
               
               
                   
                   
                   
                 AAGCCACGGACACA 
                   
                   
               
               
                   
                   
                   
                 CGCCGAGUCCAGAA 
                   
                   
               
               
                   
                   
                   
                 GCGAGGAAACAAAG 
                   
                   
               
               
                   
                   
                   
                 GGCCUGAGCGGCAA 
                   
                   
               
               
                   
                   
                   
                 AGCCCUGGGCGCCU 
                   
                   
               
               
                   
                   
                   
                 AUUCUCUUGUGGGC 
                   
                   
               
               
                   
                   
                   
                 GCCAAUGUGAAUUA 
                   
                   
               
               
                   
                   
                   
                 CGACAUUAACAAGA 
                   
                   
               
               
                   
                   
                   
                 AUCUGCGGCUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGGGCAUCAGCAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUUCGACAAGC 
                   
                   
               
               
                   
                   
                   
                 AGAUCUACAGAAGC 
                   
                   
               
               
                   
                   
                   
                 GCCGAGGGCGCCAA 
                   
                   
               
               
                   
                   
                   
                 CACCUACAAUGAAC 
                   
                   
               
               
                   
                   
                   
                 CUGGCAGAGCCUAC 
                   
                   
               
               
                   
                   
                   
                 UAUGCUGGCGUGAC 
                   
                   
               
               
                   
                   
                   
                 CGCCAGCUUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 75 
                 76 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 197 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 76, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_iroN_N 
                 MGLQTTKWPSHGAF 
                 AUGGGCCUGCAGAC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 GM_nFLR 
                 FLKSWLIISLGLYSQV 
                 CACAAAGUGGCCUU 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 T2_cHis 
                 SKLLAAESTDDNGET 
                 CUCACGGCGCAUUC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 IVVESTAEQVLKQQP 
                 UUUCUGAAGUCCUG 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 GVSIITRDDIQKNPPV 
                 GCUGAUCAUCUCCC 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NDLADIIRKMPGVNL 
                 UGGGCCUGUACAGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 ASNSASGTRGNNRQI 
                 CAGGUGUCCAAACU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 DIRGMGPENTLVLID 
                 GCUGGCCGCCGAGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 GVPVTSRNSVRYSW 
                 GCACCGACGAUAAC 
                   
                 UCCCCC 
               
               
                   
                   
                 RGERDTRGDTNWVP 
                 GGCGAGACAAUCGU 
                   
                 CAGCCC 
               
               
                   
                   
                 PEMVERIEMIRGPAA 
                 GGUGGAAAGCACCG 
                   
                 CUCCUC 
               
               
                   
                   
                 ARYGSGAAGGVVNII 
                 CCGAACAGGUGCUG 
                   
                 CCCUUC 
               
               
                   
                   
                 TKRPTNDWHGSLSLY 
                 AAACAGCAGCCUGG 
                   
                 CUGCAC 
               
               
                   
                   
                 TNYPESSKEGDTRRG 
                 CGUGUCCAUCAUCA 
                   
                 CCGUAC 
               
               
                   
                   
                 NFALSGPLAGDTLTM 
                 CCCGGGACGACAUC 
                   
                 CCCCGU 
               
               
                   
                   
                 RLYGNLNRADADSW 
                 CAGAAGAACCCUCC 
                   
                 GGUCUU 
               
               
                   
                   
                 DINSSAGTKNAAGRE 
                 AGUCAACGACCUGG 
                   
                 UGAAUA 
               
               
                   
                   
                 GVTNKDINSVFSWK 
                 CCGACAUCAUCAGA 
                   
                 AAGUCU 
               
               
                   
                   
                 MTPQQILDFEAGYSR 
                 AAGAUGCCCGGCGU 
                   
                 GAGUGG 
               
               
                   
                   
                 QGNIYAGDTQNSNSN 
                 GAACCUGGCCAGCA 
                   
                 GCGGC 
               
               
                   
                   
                 AVTKSLAQSGRETNR 
                 AUAGCGCCUCUGGC 
                   
                   
               
               
                   
                   
                 LYRQNYGLTHNGIW 
                 ACCCGGGGCAACAA 
                   
                   
               
               
                   
                   
                 GWGQSRLGFYYEKT 
                 CAGACAGAUCGACA 
                   
                   
               
               
                   
                   
                 DNTRMNEGLSGGGE 
                 UCAGAGGCAUGGGC 
                   
                   
               
               
                   
                   
                 GRITNDQTFTTNRLTS 
                 CCCGAGAAUACCCU 
                   
                   
               
               
                   
                   
                 YRTSGEVNVPVIWLF 
                 GGUGCUGAUUGAUG 
                   
                   
               
               
                   
                   
                 EQTLTVGAEWNRDE 
                 GCGUGCCCGUGACC 
                   
                   
               
               
                   
                   
                 LNDPSSTSLTVKDSNI 
                 AGCAGAAACAGCGU 
                   
                   
               
               
                   
                   
                 AGIPGSAANRASKNK 
                 GCGGUAUUCUUGGA 
                   
                   
               
               
                   
                   
                 SEISALYVEDNIEPMA 
                 GAGGCGAGAGAGAC 
                   
                   
               
               
                   
                   
                 GTNIIPGLRFDYLSES 
                 ACCAGAGGCGACAC 
                   
                   
               
               
                   
                   
                 GSNFSPSLNLAQELG 
                 CAAUUGGGUGCCAC 
                   
                   
               
               
                   
                   
                 EFVKVKAGIARAFKA 
                 CUGAGAUGGUGGAA 
                   
                   
               
               
                   
                   
                 PNLYQTSEGYLLYSK 
                 CGGAUCGAGAUGAU 
                   
                   
               
               
                   
                   
                 GNGCPKDITSGGCYL 
                 UAGAGGCCCCGCUG 
                   
                   
               
               
                   
                   
                 VGNKNLDPEISINKEI 
                 CCGCCAGAUAUGGA 
                   
                   
               
               
                   
                   
                 GLEFTVDDYHASVTY 
                 UCUGGUGCUGCUGG 
                   
                   
               
               
                   
                   
                 FRNDYQNKIVAGDQI 
                 CGGCGUGGUCAAUA 
                   
                   
               
               
                   
                   
                 IGRSASGAYVLQWQ 
                 UCAUCACCAAGAGG 
                   
                   
               
               
                   
                   
                 NGGKALIEGIEASMA 
                 CCCACCAACGACUG 
                   
                   
               
               
                   
                   
                 VPLMPDRLNWNTNA 
                 GCACGGCAGCCUGA 
                   
                   
               
               
                   
                   
                 AYMITSEQKDTGNPL 
                 GCCUGUAUACAAAC 
                   
                   
               
               
                   
                   
                 SIIPKYTVNTFLDWTI 
                 UACCCCGAGAGCAG 
                   
                   
               
               
                   
                   
                 TNALSANVNWTLYG 
                 CAAAGAGGGCGAUA 
                   
                   
               
               
                   
                   
                 KQKPRTHAESRSEET 
                 CCAGAAGAGGCAAC 
                   
                   
               
               
                   
                   
                 KGLSGKALGAYSLV 
                 UUUGCCCUGUCUGG 
                   
                   
               
               
                   
                   
                 GANVNYDINKNLRL 
                 CCCUCUGGCCGGCG 
                   
                   
               
               
                   
                   
                 NVGISNIFDKQIYRSA 
                 AUACCCUGACAAUG 
                   
                   
               
               
                   
                   
                 EGANTYNEPGRAYY 
                 AGACUGUACGGCAA 
                   
                   
               
               
                   
                   
                 AGVTASFHHHHHH 
                 CCUGAACCGGGCCG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGAUAGCUGG 
                   
                   
               
               
                   
                   
                   
                 GACAUCAAUAGCAG 
                   
                   
               
               
                   
                   
                   
                 CGCCGGCACCAAGA 
                   
                   
               
               
                   
                   
                   
                 AUGCCGCCGGAAGA 
                   
                   
               
               
                   
                   
                   
                 GAAGGCGUGACCAA 
                   
                   
               
               
                   
                   
                   
                 CAAGGACAUCAACA 
                   
                   
               
               
                   
                   
                   
                 GCGUGUUCAGCUGG 
                   
                   
               
               
                   
                   
                   
                 AAGAUGACCCCUCA 
                   
                   
               
               
                   
                   
                   
                 GCAGAUCCUGGAUU 
                   
                   
               
               
                   
                   
                   
                 UCGAGGCCGGCUAU 
                   
                   
               
               
                   
                   
                   
                 AGCAGACAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUAUGCCGGCG 
                   
                   
               
               
                   
                   
                   
                 ACACCCAGAACAGC 
                   
                   
               
               
                   
                   
                   
                 AACAGCAACGCCGU 
                   
                   
               
               
                   
                   
                   
                 GACCAAGUCUCUGG 
                   
                   
               
               
                   
                   
                   
                 CCCAGUCUGGCAGA 
                   
                   
               
               
                   
                   
                   
                 GAGACAAACAGGCU 
                   
                   
               
               
                   
                   
                   
                 GUACCGGCAGAACU 
                   
                   
               
               
                   
                   
                   
                 ACGGCCUGACACAC 
                   
                   
               
               
                   
                   
                   
                 AAUGGCAUCUGGGG 
                   
                   
               
               
                   
                   
                   
                 CUGGGGACAGUCUA 
                   
                   
               
               
                   
                   
                   
                 GGCUGGGCUUCUAC 
                   
                   
               
               
                   
                   
                   
                 UACGAGAAGACCGA 
                   
                   
               
               
                   
                   
                   
                 CAACACCCGGAUGA 
                   
                   
               
               
                   
                   
                   
                 ACGAGGGACUUUCU 
                   
                   
               
               
                   
                   
                   
                 GGCGGCGGAGAGGG 
                   
                   
               
               
                   
                   
                   
                 CAGAAUCACCAACG 
                   
                   
               
               
                   
                   
                   
                 AUCAGACCUUCACC 
                   
                   
               
               
                   
                   
                   
                 ACCAACCGGCUGAC 
                   
                   
               
               
                   
                   
                   
                 CAGCUACAGAACCA 
                   
                   
               
               
                   
                   
                   
                 GCGGCGAAGUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGCCAGUGAUCUG 
                   
                   
               
               
                   
                   
                   
                 GCUGUUCGAGCAGA 
                   
                   
               
               
                   
                   
                   
                 CCCUGACAGUGGGC 
                   
                   
               
               
                   
                   
                   
                 GCCGAGUGGAAUAG 
                   
                   
               
               
                   
                   
                   
                 AGAUGAGCUGAACG 
                   
                   
               
               
                   
                   
                   
                 ACCCCAGCUCCACC 
                   
                   
               
               
                   
                   
                   
                 AGCCUGACCGUGAA 
                   
                   
               
               
                   
                   
                   
                 GGACUCUAAUAUCG 
                   
                   
               
               
                   
                   
                   
                 CUGGCAUCCCUGGC 
                   
                   
               
               
                   
                   
                   
                 AGCGCCGCCAACAG 
                   
                   
               
               
                   
                   
                   
                 AGCCAGCAAGAACA 
                   
                   
               
               
                   
                   
                   
                 AGAGCGAGAUCAGC 
                   
                   
               
               
                   
                   
                   
                 GCCCUGUACGUCGA 
                   
                   
               
               
                   
                   
                   
                 GGACAACAUCGAAC 
                   
                   
               
               
                   
                   
                   
                 CUAUGGCCGGCACA 
                   
                   
               
               
                   
                   
                   
                 AACAUCAUCCCCGG 
                   
                   
               
               
                   
                   
                   
                 CCUGAGAUUCGACU 
                   
                   
               
               
                   
                   
                   
                 ACCUGAGCGAGAGC 
                   
                   
               
               
                   
                   
                   
                 GGCAGCAACUUCAG 
                   
                   
               
               
                   
                   
                   
                 CCCCAGCCUGAAUC 
                   
                   
               
               
                   
                   
                   
                 UGGCUCAAGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GGCGAGUUCGUGAA 
                   
                   
               
               
                   
                   
                   
                 AGUGAAGGCCGGAA 
                   
                   
               
               
                   
                   
                   
                 UCGCCAGAGCCUUC 
                   
                   
               
               
                   
                   
                   
                 AAGGCCCCUAAUCU 
                   
                   
               
               
                   
                   
                   
                 GUACCAGACCAGCG 
                   
                   
               
               
                   
                   
                   
                 AGGGCUACCUGCUG 
                   
                   
               
               
                   
                   
                   
                 UACUCCAAAGGCAA 
                   
                   
               
               
                   
                   
                   
                 CGGCUGCCCCAAGG 
                   
                   
               
               
                   
                   
                   
                 AUAUCACAAGCGGC 
                   
                   
               
               
                   
                   
                   
                 GGCUGUUACCUCGU 
                   
                   
               
               
                   
                   
                   
                 GGGCAACAAGAACC 
                   
                   
               
               
                   
                   
                   
                 UGGAUCCUGAGAUC 
                   
                   
               
               
                   
                   
                   
                 AGCAUCAACAAAGA 
                   
                   
               
               
                   
                   
                   
                 GAUCGGCCUGGAAU 
                   
                   
               
               
                   
                   
                   
                 UCACCGUGGACGAC 
                   
                   
               
               
                   
                   
                   
                 UACCACGCCAGCGU 
                   
                   
               
               
                   
                   
                   
                 GACCUACUUCCGGA 
                   
                   
               
               
                   
                   
                   
                 ACGAUUACCAGAAC 
                   
                   
               
               
                   
                   
                   
                 AAGAUCGUGGCCGG 
                   
                   
               
               
                   
                   
                   
                 GGACCAGAUCAUCG 
                   
                   
               
               
                   
                   
                   
                 GCAGAAGUGCUAGC 
                   
                   
               
               
                   
                   
                   
                 GGAGCCUACGUGCU 
                   
                   
               
               
                   
                   
                   
                 GCAAUGGCAGAAUG 
                   
                   
               
               
                   
                   
                   
                 GCGGAAAGGCCCUG 
                   
                   
               
               
                   
                   
                   
                 AUCGAGGGAAUCGA 
                   
                   
               
               
                   
                   
                   
                 GGCUUCUAUGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGCCACUGAUGCCC 
                   
                   
               
               
                   
                   
                   
                 GACAGACUGAACUG 
                   
                   
               
               
                   
                   
                   
                 GAACACCAACGCCG 
                   
                   
               
               
                   
                   
                   
                 CCUACAUGAUCACC 
                   
                   
               
               
                   
                   
                   
                 AGCGAGCAGAAGGA 
                   
                   
               
               
                   
                   
                   
                 CACCGGCAAUCCUC 
                   
                   
               
               
                   
                   
                   
                 UGAGCAUCAUCCCU 
                   
                   
               
               
                   
                   
                   
                 AAGUAUACCGUGAA 
                   
                   
               
               
                   
                   
                   
                 CACCUUCCUGGACU 
                   
                   
               
               
                   
                   
                   
                 GGACCAUCACAAAC 
                   
                   
               
               
                   
                   
                   
                 GCCCUGAGCGCCAA 
                   
                   
               
               
                   
                   
                   
                 CGUGAACUGGACCC 
                   
                   
               
               
                   
                   
                   
                 UGUAUGGCAAGCAG 
                   
                   
               
               
                   
                   
                   
                 AAGCCACGGACACA 
                   
                   
               
               
                   
                   
                   
                 CGCCGAGUCCAGAA 
                   
                   
               
               
                   
                   
                   
                 GCGAGGAAACAAAG 
                   
                   
               
               
                   
                   
                   
                 GGCCUGAGCGGCAA 
                   
                   
               
               
                   
                   
                   
                 AGCCCUGGGCGCCU 
                   
                   
               
               
                   
                   
                   
                 AUUCUCUUGUGGGC 
                   
                   
               
               
                   
                   
                   
                 GCCAAUGUGAAUUA 
                   
                   
               
               
                   
                   
                   
                 CGACAUUAACAAGA 
                   
                   
               
               
                   
                   
                   
                 AUCUGCGGCUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGGGCAUCAGCAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUUCGACAAGC 
                   
                   
               
               
                   
                   
                   
                 AGAUCUACAGAAGC 
                   
                   
               
               
                   
                   
                   
                 GCCGAGGGCGCCAA 
                   
                   
               
               
                   
                   
                   
                 CACCUACAAUGAAC 
                   
                   
               
               
                   
                   
                   
                 CUGGCAGAGCCUAC 
                   
                   
               
               
                   
                   
                   
                 UAUGCUGGCGUGAC 
                   
                   
               
               
                   
                   
                   
                 CGCCAGCUUCCAUC 
                   
                   
               
               
                   
                   
                   
                 ACCACCAUCAUCAU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 77 
                 78 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 198 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 78, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_iroN_N 
                 MGLQTTKWPSHGAF 
                 AUGGGCCUGCAGAC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 GM_nFLR 
                 FLKSWLIISLGLYSQV 
                 CACAAAGUGGCCUU 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 T2 
                 SKLLAAESTDDNGET 
                 CUCACGGCGCAUUC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 IVVESTAEQVLKQQP 
                 UUUCUGAAGUCCUG 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 GVSIITRDDIQKNPPV 
                 GCUGAUCAUCUCCC 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NDLADIIRKMPGVNL 
                 UGGGCCUGUACAGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 ASNSASGTRGNNRQI 
                 CAGGUGUCCAAACU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 DIRGMGPENTLVLID 
                 GCUGGCCGCCGAGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 GVPVTSRNSVRYSW 
                 GCACCGACGAUAAC 
                   
                 UCCCCC 
               
               
                   
                   
                 RGERDTRGDTNWVP 
                 GGCGAGACAAUCGU 
                   
                 CAGCCC 
               
               
                   
                   
                 PEMVERIEMIRGPAA 
                 GGUGGAAAGCACCG 
                   
                 CUCCUC 
               
               
                   
                   
                 ARYGSGAAGGVVNII 
                 CCGAACAGGUGCUG 
                   
                 CCCUUC 
               
               
                   
                   
                 TKRPTNDWHGSLSLY 
                 AAACAGCAGCCUGG 
                   
                 CUGCAC 
               
               
                   
                   
                 TNYPESSKEGDTRRG 
                 CGUGUCCAUCAUCA 
                   
                 CCGUAC 
               
               
                   
                   
                 NFALSGPLAGDTLTM 
                 CCCGGGACGACAUC 
                   
                 CCCCGU 
               
               
                   
                   
                 RLYGNLNRADADSW 
                 CAGAAGAACCCUCC 
                   
                 GGUCUU 
               
               
                   
                   
                 DINSSAGTKNAAGRE 
                 AGUCAACGACCUGG 
                   
                 UGAAUA 
               
               
                   
                   
                 GVTNKDINSVFSWK 
                 CCGACAUCAUCAGA 
                   
                 AAGUCU 
               
               
                   
                   
                 MTPQQILDFEAGYSR 
                 AAGAUGCCCGGCGU 
                   
                 GAGUGG 
               
               
                   
                   
                 QGNIYAGDTQNSNSN 
                 GAACCUGGCCAGCA 
                   
                 GCGGC 
               
               
                   
                   
                 AVTKSLAQSGRETNR 
                 AUAGCGCCUCUGGC 
                   
                   
               
               
                   
                   
                 LYRQNYGLTHNGIW 
                 ACCCGGGGCAACAA 
                   
                   
               
               
                   
                   
                 GWGQSRLGFYYEKT 
                 CAGACAGAUCGACA 
                   
                   
               
               
                   
                   
                 DNTRMNEGLSGGGE 
                 UCAGAGGCAUGGGC 
                   
                   
               
               
                   
                   
                 GRITNDQTFTTNRLTS 
                 CCCGAGAAUACCCU 
                   
                   
               
               
                   
                   
                 YRTSGEVNVPVIWLF 
                 GGUGCUGAUUGAUG 
                   
                   
               
               
                   
                   
                 EQTLTVGAEWNRDE 
                 GCGUGCCCGUGACC 
                   
                   
               
               
                   
                   
                 LNDPSSTSLTVKDSNI 
                 AGCAGAAACAGCGU 
                   
                   
               
               
                   
                   
                 AGIPGSAANRASKNK 
                 GCGGUAUUCUUGGA 
                   
                   
               
               
                   
                   
                 SEISALYVEDNIEPMA 
                 GAGGCGAGAGAGAC 
                   
                   
               
               
                   
                   
                 GTNIIPGLRFDYLSES 
                 ACCAGAGGCGACAC 
                   
                   
               
               
                   
                   
                 GSNFSPSLNLAQELG 
                 CAAUUGGGUGCCAC 
                   
                   
               
               
                   
                   
                 EFVKVKAGIARAFKA 
                 CUGAGAUGGUGGAA 
                   
                   
               
               
                   
                   
                 PNLYQTSEGYLLYSK 
                 CGGAUCGAGAUGAU 
                   
                   
               
               
                   
                   
                 GNGCPKDITSGGCYL 
                 UAGAGGCCCCGCUG 
                   
                   
               
               
                   
                   
                 VGNKNLDPEISINKEI 
                 CCGCCAGAUAUGGA 
                   
                   
               
               
                   
                   
                 GLEFTVDDYHASVTY 
                 UCUGGUGCUGCUGG 
                   
                   
               
               
                   
                   
                 FRNDYQNKIVAGDQI 
                 CGGCGUGGUCAAUA 
                   
                   
               
               
                   
                   
                 IGRSASGAYVLQWQ 
                 UCAUCACCAAGAGG 
                   
                   
               
               
                   
                   
                 NGGKALIEGIEASMA 
                 CCCACCAACGACUG 
                   
                   
               
               
                   
                   
                 VPLMPDRLNWNTNA 
                 GCACGGCAGCCUGA 
                   
                   
               
               
                   
                   
                 AYMITSEQKDTGNPL 
                 GCCUGUAUACAAAC 
                   
                   
               
               
                   
                   
                 SIIPKYTVNTFLDWTI 
                 UACCCCGAGAGCAG 
                   
                   
               
               
                   
                   
                 TNALSANVNWTLYG 
                 CAAAGAGGGCGAUA 
                   
                   
               
               
                   
                   
                 KQKPRTHAESRSEET 
                 CCAGAAGAGGCAAC 
                   
                   
               
               
                   
                   
                 KGLSGKALGAYSLV 
                 UUUGCCCUGUCUGG 
                   
                   
               
               
                   
                   
                 GANVNYDINKNLRL 
                 CCCUCUGGCCGGCG 
                   
                   
               
               
                   
                   
                 NVGISNIFDKQIYRSA 
                 AUACCCUGACAAUG 
                   
                   
               
               
                   
                   
                 EGANTYNEPGRAYY 
                 AGACUGUACGGCAA 
                   
                   
               
               
                   
                   
                 AGVTASF 
                 CCUGAACCGGGCCG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGAUAGCUGG 
                   
                   
               
               
                   
                   
                   
                 GACAUCAAUAGCAG 
                   
                   
               
               
                   
                   
                   
                 CGCCGGCACCAAGA 
                   
                   
               
               
                   
                   
                   
                 AUGCCGCCGGAAGA 
                   
                   
               
               
                   
                   
                   
                 GAAGGCGUGACCAA 
                   
                   
               
               
                   
                   
                   
                 CAAGGACAUCAACA 
                   
                   
               
               
                   
                   
                   
                 GCGUGUUCAGCUGG 
                   
                   
               
               
                   
                   
                   
                 AAGAUGACCCCUCA 
                   
                   
               
               
                   
                   
                   
                 GCAGAUCCUGGAUU 
                   
                   
               
               
                   
                   
                   
                 UCGAGGCCGGCUAU 
                   
                   
               
               
                   
                   
                   
                 AGCAGACAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUAUGCCGGCG 
                   
                   
               
               
                   
                   
                   
                 ACACCCAGAACAGC 
                   
                   
               
               
                   
                   
                   
                 AACAGCAACGCCGU 
                   
                   
               
               
                   
                   
                   
                 GACCAAGUCUCUGG 
                   
                   
               
               
                   
                   
                   
                 CCCAGUCUGGCAGA 
                   
                   
               
               
                   
                   
                   
                 GAGACAAACAGGCU 
                   
                   
               
               
                   
                   
                   
                 GUACCGGCAGAACU 
                   
                   
               
               
                   
                   
                   
                 ACGGCCUGACACAC 
                   
                   
               
               
                   
                   
                   
                 AAUGGCAUCUGGGG 
                   
                   
               
               
                   
                   
                   
                 CUGGGGACAGUCUA 
                   
                   
               
               
                   
                   
                   
                 GGCUGGGCUUCUAC 
                   
                   
               
               
                   
                   
                   
                 UACGAGAAGACCGA 
                   
                   
               
               
                   
                   
                   
                 CAACACCCGGAUGA 
                   
                   
               
               
                   
                   
                   
                 ACGAGGGACUUUCU 
                   
                   
               
               
                   
                   
                   
                 GGCGGCGGAGAGGG 
                   
                   
               
               
                   
                   
                   
                 CAGAAUCACCAACG 
                   
                   
               
               
                   
                   
                   
                 AUCAGACCUUCACC 
                   
                   
               
               
                   
                   
                   
                 ACCAACCGGCUGAC 
                   
                   
               
               
                   
                   
                   
                 CAGCUACAGAACCA 
                   
                   
               
               
                   
                   
                   
                 GCGGCGAAGUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGCCAGUGAUCUG 
                   
                   
               
               
                   
                   
                   
                 GCUGUUCGAGCAGA 
                   
                   
               
               
                   
                   
                   
                 CCCUGACAGUGGGC 
                   
                   
               
               
                   
                   
                   
                 GCCGAGUGGAAUAG 
                   
                   
               
               
                   
                   
                   
                 AGAUGAGCUGAACG 
                   
                   
               
               
                   
                   
                   
                 ACCCCAGCUCCACC 
                   
                   
               
               
                   
                   
                   
                 AGCCUGACCGUGAA 
                   
                   
               
               
                   
                   
                   
                 GGACUCUAAUAUCG 
                   
                   
               
               
                   
                   
                   
                 CUGGCAUCCCUGGC 
                   
                   
               
               
                   
                   
                   
                 AGCGCCGCCAACAG 
                   
                   
               
               
                   
                   
                   
                 AGCCAGCAAGAACA 
                   
                   
               
               
                   
                   
                   
                 AGAGCGAGAUCAGC 
                   
                   
               
               
                   
                   
                   
                 GCCCUGUACGUCGA 
                   
                   
               
               
                   
                   
                   
                 GGACAACAUCGAAC 
                   
                   
               
               
                   
                   
                   
                 CUAUGGCCGGCACA 
                   
                   
               
               
                   
                   
                   
                 AACAUCAUCCCCGG 
                   
                   
               
               
                   
                   
                   
                 CCUGAGAUUCGACU 
                   
                   
               
               
                   
                   
                   
                 ACCUGAGCGAGAGC 
                   
                   
               
               
                   
                   
                   
                 GGCAGCAACUUCAG 
                   
                   
               
               
                   
                   
                   
                 CCCCAGCCUGAAUC 
                   
                   
               
               
                   
                   
                   
                 UGGCUCAAGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GGCGAGUUCGUGAA 
                   
                   
               
               
                   
                   
                   
                 AGUGAAGGCCGGAA 
                   
                   
               
               
                   
                   
                   
                 UCGCCAGAGCCUUC 
                   
                   
               
               
                   
                   
                   
                 AAGGCCCCUAAUCU 
                   
                   
               
               
                   
                   
                   
                 GUACCAGACCAGCG 
                   
                   
               
               
                   
                   
                   
                 AGGGCUACCUGCUG 
                   
                   
               
               
                   
                   
                   
                 UACUCCAAAGGCAA 
                   
                   
               
               
                   
                   
                   
                 CGGCUGCCCCAAGG 
                   
                   
               
               
                   
                   
                   
                 AUAUCACAAGCGGC 
                   
                   
               
               
                   
                   
                   
                 GGCUGUUACCUCGU 
                   
                   
               
               
                   
                   
                   
                 GGGCAACAAGAACC 
                   
                   
               
               
                   
                   
                   
                 UGGAUCCUGAGAUC 
                   
                   
               
               
                   
                   
                   
                 AGCAUCAACAAAGA 
                   
                   
               
               
                   
                   
                   
                 GAUCGGCCUGGAAU 
                   
                   
               
               
                   
                   
                   
                 UCACCGUGGACGAC 
                   
                   
               
               
                   
                   
                   
                 UACCACGCCAGCGU 
                   
                   
               
               
                   
                   
                   
                 GACCUACUUCCGGA 
                   
                   
               
               
                   
                   
                   
                 ACGAUUACCAGAAC 
                   
                   
               
               
                   
                   
                   
                 AAGAUCGUGGCCGG 
                   
                   
               
               
                   
                   
                   
                 GGACCAGAUCAUCG 
                   
                   
               
               
                   
                   
                   
                 GCAGAAGUGCUAGC 
                   
                   
               
               
                   
                   
                   
                 GGAGCCUACGUGCU 
                   
                   
               
               
                   
                   
                   
                 GCAAUGGCAGAAUG 
                   
                   
               
               
                   
                   
                   
                 GCGGAAAGGCCCUG 
                   
                   
               
               
                   
                   
                   
                 AUCGAGGGAAUCGA 
                   
                   
               
               
                   
                   
                   
                 GGCUUCUAUGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGCCACUGAUGCCC 
                   
                   
               
               
                   
                   
                   
                 GACAGACUGAACUG 
                   
                   
               
               
                   
                   
                   
                 GAACACCAACGCCG 
                   
                   
               
               
                   
                   
                   
                 CCUACAUGAUCACC 
                   
                   
               
               
                   
                   
                   
                 AGCGAGCAGAAGGA 
                   
                   
               
               
                   
                   
                   
                 CACCGGCAAUCCUC 
                   
                   
               
               
                   
                   
                   
                 UGAGCAUCAUCCCU 
                   
                   
               
               
                   
                   
                   
                 AAGUAUACCGUGAA 
                   
                   
               
               
                   
                   
                   
                 CACCUUCCUGGACU 
                   
                   
               
               
                   
                   
                   
                 GGACCAUCACAAAC 
                   
                   
               
               
                   
                   
                   
                 GCCCUGAGCGCCAA 
                   
                   
               
               
                   
                   
                   
                 CGUGAACUGGACCC 
                   
                   
               
               
                   
                   
                   
                 UGUAUGGCAAGCAG 
                   
                   
               
               
                   
                   
                   
                 AAGCCACGGACACA 
                   
                   
               
               
                   
                   
                   
                 CGCCGAGUCCAGAA 
                   
                   
               
               
                   
                   
                   
                 GCGAGGAAACAAAG 
                   
                   
               
               
                   
                   
                   
                 GGCCUGAGCGGCAA 
                   
                   
               
               
                   
                   
                   
                 AGCCCUGGGCGCCU 
                   
                   
               
               
                   
                   
                   
                 AUUCUCUUGUGGGC 
                   
                   
               
               
                   
                   
                   
                 GCCAAUGUGAAUUA 
                   
                   
               
               
                   
                   
                   
                 CGACAUUAACAAGA 
                   
                   
               
               
                   
                   
                   
                 AUCUGCGGCUGAAC 
                   
                   
               
               
                   
                   
                   
                 GUGGGCAUCAGCAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUUCGACAAGC 
                   
                   
               
               
                   
                   
                   
                 AGAUCUACAGAAGC 
                   
                   
               
               
                   
                   
                   
                 GCCGAGGGCGCCAA 
                   
                   
               
               
                   
                   
                   
                 CACCUACAAUGAAC 
                   
                   
               
               
                   
                   
                   
                 CUGGCAGAGCCUAC 
                   
                   
               
               
                   
                   
                   
                 UAUGCUGGCGUGAC 
                   
                   
               
               
                   
                   
                   
                 CGCCAGCUUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 79 
                 80 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 199 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 80, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_CirA_n 
                 MGLQTTKWPSHGAF 
                 AUGGGCCUGCAGAC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 FLRT2_c 
                 FLKSWLIISLGLYSQV 
                 CACAAAGUGGCCUU 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 His 
                 SKLLAATDDGETMV 
                 CUCACGGCGCAUUC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 VTASAIEQNLKDAPA 
                 UUUCUGAAGUCCUG 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SISVITQQDLQRRPVQ 
                 GCUGAUCAUCUCCC 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NLKDVLKEVPGVQL 
                 UGGGCCUGUACAGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 TNEGDNRKGVSIRGL 
                 CAGGUGUCCAAACU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 DSSYTLILIDGKRVNS 
                 GCUGGCCGCCACCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 RNAVFRHNDFDLNW 
                 AUGAUGGCGAGACA 
                   
                 UCCCCC 
               
               
                   
                   
                 IPVDAIERIEVVRGPM 
                 AUGGUGGUUACAGC 
                   
                 CAGCCC 
               
               
                   
                   
                 SSLYGSDALGGVVNII 
                 CAGCGCCAUCGAGC 
                   
                 CUCCUC 
               
               
                   
                   
                 TKKIGQKWHGSVTV 
                 AGAACCUGAAAGAU 
                   
                 CCCUUC 
               
               
                   
                   
                 DSTIQEHRDRGDTYN 
                 GCCCCUGCCAGCAU 
                   
                 CUGCAC 
               
               
                   
                   
                 GQFFTSGPLIDGVLG 
                 CAGCGUGAUCACCC 
                   
                 CCGUAC 
               
               
                   
                   
                 MKAYGSLAKREKDE 
                 AGCAGGAUCUGCAG 
                   
                 CCCCGU 
               
               
                   
                   
                 QQSSATTATGETPRIE 
                 AGAAGGCCCGUGCA 
                   
                 GGUCUU 
               
               
                   
                   
                 GFTSRDGNVEFAWTP 
                 GAAUCUGAAGGACG 
                   
                 UGAAUA 
               
               
                   
                   
                 NENHDVTAGYGFDR 
                 UGCUGAAAGAGGUG 
                   
                 AAGUCU 
               
               
                   
                   
                 QDRDSDSLDKNRLER 
                 CCCGGCGUCCAGCU 
                   
                 GAGUGG 
               
               
                   
                   
                 QNYALSHNGRWDLG 
                 GACAAACGAGGGCG 
                   
                 GCGGC 
               
               
                   
                   
                 NSELKFYGEKVENKN 
                 AUAAUAGAAAGGGC 
                   
                   
               
               
                   
                   
                 PGNSSPITSESNSIDG 
                 GUGUCCAUCAGAGG 
                   
                   
               
               
                   
                   
                 KYVLPLASVNQFLTF 
                 CCUGGACAGCAGCU 
                   
                   
               
               
                   
                   
                 GGEWRHDKLSDAVS 
                 ACACCCUGAUCCUG 
                   
                   
               
               
                   
                   
                 LTGGSSTKTSASQYA 
                 AUCGACGGCAAGAG 
                   
                   
               
               
                   
                   
                 LFLEDEWRIFEPLALT 
                 AGUGAACAGCCGGA 
                   
                   
               
               
                   
                   
                 TGIRMDDHETYGDH 
                 ACGCCGUGUUCCGG 
                   
                   
               
               
                   
                   
                 WSPRAYLVYNATDT 
                 CACAACGACUUCGA 
                   
                   
               
               
                   
                   
                 LTVKGGWATAFKAP 
                 CCUGAACUGGAUCC 
                   
                   
               
               
                   
                   
                 SLLQLSPDWATNSCR 
                 CCGUGGAUGCCAUC 
                   
                   
               
               
                   
                   
                 GGCRIVGSPDLKPETS 
                 GAGAGGAUCGAAGU 
                   
                   
               
               
                   
                   
                 ESWELGLYYRGEEGI 
                 UGUGCGGGGACCUA 
                   
                   
               
               
                   
                   
                 LEGVEASVTTFRNDV 
                 UGAGCAGCCUGUAC 
                   
                   
               
               
                   
                   
                 DNRISISRTPDVNAAP 
                 GGAUCUGAUGCCCU 
                   
                   
               
               
                   
                   
                 GYSNFVGFETNSRGQ 
                 CGGCGGCGUGGUCA 
                   
                   
               
               
                   
                   
                 RVPVFRYYNVNKARI 
                 ACAUCAUCACCAAG 
                   
                   
               
               
                   
                   
                 QGVETELKVPFNEA 
                 AAGAUCGGCCAGAA 
                   
                   
               
               
                   
                   
                 WKLSLNYTYNDGRD 
                 AUGGCACGGCAGCG 
                   
                   
               
               
                   
                   
                 VSNGGNKPLSDLPFH 
                 UGACCGUGGAUAGC 
                   
                   
               
               
                   
                   
                 TANGTLDWKPAQLE 
                 ACCAUCCAAGAGCA 
                   
                   
               
               
                   
                   
                 DWSFYVSGNYTGRK 
                 CAGAGACAGAGGCG 
                   
                   
               
               
                   
                   
                 RADSATAKTPGGYV 
                 ACACCUACAACGGC 
                   
                   
               
               
                   
                   
                 VWDTGAAWQATKN 
                 CAGUUCUUCACAAG 
                   
                   
               
               
                   
                   
                 VKLRAGVLNVGDKD 
                 CGGCCCUCUGAUUG 
                   
                   
               
               
                   
                   
                 LKRDDYGYTEDGRR 
                 AUGGCGUGCUGGGC 
                   
                   
               
               
                   
                   
                 YFMAVDYRFHHHHH 
                 AUGAAGGCCUACGG 
                   
                   
               
               
                   
                   
                 H 
                 AUCUCUGGCCAAGA 
                   
                   
               
               
                   
                   
                   
                 GAGAGAAGGACGAG 
                   
                   
               
               
                   
                   
                   
                 CAGCAGAGCAGCGC 
                   
                   
               
               
                   
                   
                   
                 CACAACAGCCACAG 
                   
                   
               
               
                   
                   
                   
                 GCGAGACACCUAGA 
                   
                   
               
               
                   
                   
                   
                 AUCGAGGGCUUCAC 
                   
                   
               
               
                   
                   
                   
                 CAGCAGAGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 ACGUGGAAUUCGCC 
                   
                   
               
               
                   
                   
                   
                 UGGACACCCAACGA 
                   
                   
               
               
                   
                   
                   
                 GAACCACGAUGUGA 
                   
                   
               
               
                   
                   
                   
                 CAGCCGGCUACGGC 
                   
                   
               
               
                   
                   
                   
                 UUCGACAGACAGGA 
                   
                   
               
               
                   
                   
                   
                 CAGAGAUAGCGACA 
                   
                   
               
               
                   
                   
                   
                 GCCUGGACAAGAAC 
                   
                   
               
               
                   
                   
                   
                 CGGCUGGAAAGACA 
                   
                   
               
               
                   
                   
                   
                 GAACUACGCCCUGA 
                   
                   
               
               
                   
                   
                   
                 GCCACAACGGCAGA 
                   
                   
               
               
                   
                   
                   
                 UGGGACCUGGGAAA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAGCUGAAGU 
                   
                   
               
               
                   
                   
                   
                 UCUACGGCGAGAAG 
                   
                   
               
               
                   
                   
                   
                 GUCGAGAACAAGAA 
                   
                   
               
               
                   
                   
                   
                 CCCCGGCAACAGCA 
                   
                   
               
               
                   
                   
                   
                 GCCCUAUCACCAGC 
                   
                   
               
               
                   
                   
                   
                 GAGAGCAACAGCAU 
                   
                   
               
               
                   
                   
                   
                 CGAUGGCAAAUACG 
                   
                   
               
               
                   
                   
                   
                 UGCUGCCCCUGGCC 
                   
                   
               
               
                   
                   
                   
                 UCCGUGAAUCAGUU 
                   
                   
               
               
                   
                   
                   
                 CCUGACAUUUGGCG 
                   
                   
               
               
                   
                   
                   
                 GAGAGUGGCGGCAC 
                   
                   
               
               
                   
                   
                   
                 GACAAGCUGUCUGA 
                   
                   
               
               
                   
                   
                   
                 UGCCGUUUCUCUGA 
                   
                   
               
               
                   
                   
                   
                 CCGGCGGCAGCAGC 
                   
                   
               
               
                   
                   
                   
                 ACAAAGACAAGCGC 
                   
                   
               
               
                   
                   
                   
                 CUCUCAGUACGCCC 
                   
                   
               
               
                   
                   
                   
                 UGUUCCUGGAAGAU 
                   
                   
               
               
                   
                   
                   
                 GAGUGGCGGAUCUU 
                   
                   
               
               
                   
                   
                   
                 CGAGCCCCUGGCUC 
                   
                   
               
               
                   
                   
                   
                 UGACAACAGGCAUC 
                   
                   
               
               
                   
                   
                   
                 AGAAUGGACGACCA 
                   
                   
               
               
                   
                   
                   
                 CGAGACAUACGGCG 
                   
                   
               
               
                   
                   
                   
                 ACCACUGGUCCCCA 
                   
                   
               
               
                   
                   
                   
                 AGAGCCUACCUGGU 
                   
                   
               
               
                   
                   
                   
                 GUACAACGCCACCG 
                   
                   
               
               
                   
                   
                   
                 ACACACUGACCGUG 
                   
                   
               
               
                   
                   
                   
                 AAAGGCGGAUGGGC 
                   
                   
               
               
                   
                   
                   
                 CACAGCCUUUAAGG 
                   
                   
               
               
                   
                   
                   
                 CUCCUAGUCUGCUG 
                   
                   
               
               
                   
                   
                   
                 CAGCUGAGCCCCGA 
                   
                   
               
               
                   
                   
                   
                 UUGGGCCACCAAUU 
                   
                   
               
               
                   
                   
                   
                 CUUGUAGAGGCGGC 
                   
                   
               
               
                   
                   
                   
                 UGCAGAAUCGUGGG 
                   
                   
               
               
                   
                   
                   
                 CAGCCCUGAUCUGA 
                   
                   
               
               
                   
                   
                   
                 AGCCCGAGACAUCU 
                   
                   
               
               
                   
                   
                   
                 GAGUCUUGGGAGCU 
                   
                   
               
               
                   
                   
                   
                 GGGACUGUACUACA 
                   
                   
               
               
                   
                   
                   
                 GGGGCGAAGAGGGA 
                   
                   
               
               
                   
                   
                   
                 AUCCUGGAAGGCGU 
                   
                   
               
               
                   
                   
                   
                 GGAAGCCAGCGUGA 
                   
                   
               
               
                   
                   
                   
                 CAACCUUCAGAAAC 
                   
                   
               
               
                   
                   
                   
                 GACGUGGACAACCG 
                   
                   
               
               
                   
                   
                   
                 GAUCAGCAUCUCCA 
                   
                   
               
               
                   
                   
                   
                 GAACACCCGACGUG 
                   
                   
               
               
                   
                   
                   
                 AACGCCGCUCCUGG 
                   
                   
               
               
                   
                   
                   
                 CUACUCUAAUUUCG 
                   
                   
               
               
                   
                   
                   
                 AACAGCAGAGGCCA 
                   
                   
               
               
                   
                   
                   
                 GAGGGUGCCCGUGU 
                   
                   
               
               
                   
                   
                   
                 UUCGGUACUACAAC 
                   
                   
               
               
                   
                   
                   
                 GUGAACAAGGCCCG 
                   
                   
               
               
                   
                   
                   
                 GAUCCAGGGCGUCG 
                   
                   
               
               
                   
                   
                   
                 AGACAGAGCUGAAG 
                   
                   
               
               
                   
                   
                   
                 GUGCCCUUUAACGA 
                   
                   
               
               
                   
                   
                   
                 AGCCUGGAAGCUGA 
                   
                   
               
               
                   
                   
                   
                 GCCUGAACUACACA 
                   
                   
               
               
                   
                   
                   
                 UACAACGACGGCCG 
                   
                   
               
               
                   
                   
                   
                 GGACGUGUCCAACG 
                   
                   
               
               
                   
                   
                   
                 GCGGAAACAAACCU 
                   
                   
               
               
                   
                   
                   
                 CUGAGCGACCUGCC 
                   
                   
               
               
                   
                   
                   
                 UUUCCACACCGCCA 
                   
                   
               
               
                   
                   
                   
                 AUGGCACCCUGGAU 
                   
                   
               
               
                   
                   
                   
                 UGGAAGCCUGCUCA 
                   
                   
               
               
                   
                   
                   
                 GCUGGAAGAUUGGA 
                   
                   
               
               
                   
                   
                   
                 GCUUCUACGUGUCC 
                   
                   
               
               
                   
                   
                   
                 GGCAACUACACCGG 
                   
                   
               
               
                   
                   
                   
                 CAGAAAGAGAGCCG 
                   
                   
               
               
                   
                   
                   
                 AUAGCGCCACCGCU 
                   
                   
               
               
                   
                   
                   
                 AAGACACCAGGCGG 
                   
                   
               
               
                   
                   
                   
                 AUACGUCGUGUGGG 
                   
                   
               
               
                   
                   
                   
                 AUACAGGUGCUGCU 
                   
                   
               
               
                   
                   
                   
                 UGGCAGGCCACCAA 
                   
                   
               
               
                   
                   
                   
                 GAACGUGAAACUGA 
                   
                   
               
               
                   
                   
                   
                 GAGCCGGCGUGCUG 
                   
                   
               
               
                   
                   
                   
                 AACGUGGGCGACAA 
                   
                   
               
               
                   
                   
                   
                 AGACCUGAAGAGGG 
                   
                   
               
               
                   
                   
                   
                 ACGACUACGGCUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAGGACGGCAG 
                   
                   
               
               
                   
                   
                   
                 ACGGUACUUCAUGG 
                   
                   
               
               
                   
                   
                   
                 CCGUGGACUACCGG 
                   
                   
               
               
                   
                   
                   
                 UUCCACCACCACCA 
                   
                   
               
               
                   
                   
                   
                 UCACCAU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 81 
                 82 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 200 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 82, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_CirA_n 
                 MGLQTTKWPSHGAF 
                 AUGGGCCUGCAGAC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 FLRT2 
                 FLKSWLIISLGLYSQV 
                 CACAAAGUGGCCUU 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 SKLLAATDDGETMV 
                 CUCACGGCGCAUUC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 VTASAIEQNLKDAPA 
                 UUUCUGAAGUCCUG 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SISVITQQDLQRRPVQ 
                 GCUGAUCAUCUCCC 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NLKDVLKEVPGVQL 
                 UGGGCCUGUACAGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 TNEGDNRKGVSIRGL 
                 CAGGUGUCCAAACU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 DSSYTLILIDGKRVNS 
                 GCUGGCCGCCACCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 RNAVFRHNDFDLNW 
                 AUGAUGGCGAGACA 
                   
                 UCCCCC 
               
               
                   
                   
                 IPVDAIERIEVVRGPM 
                 AUGGUGGUUACAGC 
                   
                 CAGCCC 
               
               
                   
                   
                 SSLYGSDALGGVVNII 
                 CAGCGCCAUCGAGC 
                   
                 CUCCUC 
               
               
                   
                   
                 TKKIGQKWHGSVTV 
                 AGAACCUGAAAGAU 
                   
                 CCCUUC 
               
               
                   
                   
                 DSTIQEHRDRGDTYN 
                 GCCCCUGCCAGCAU 
                   
                 CUGCAC 
               
               
                   
                   
                 GQFFTSGPLIDGVLG 
                 CAGCGUGAUCACCC 
                   
                 CCGUAC 
               
               
                   
                   
                 MKAYGSLAKREKDE 
                 AGCAGGAUCUGCAG 
                   
                 CCCCGU 
               
               
                   
                   
                 QQSSATTATGETPRIE 
                 AGAAGGCCCGUGCA 
                   
                 GGUCUU 
               
               
                   
                   
                 GFTSRDGNVEFAWTP 
                 GAAUCUGAAGGACG 
                   
                 UGAAUA 
               
               
                   
                   
                 NENHDVTAGYGFDR 
                 UGCUGAAAGAGGUG 
                   
                 AAGUCU 
               
               
                   
                   
                 QDRDSDSLDKNRLER 
                 CCCGGCGUCCAGCU 
                   
                 GAGUGG 
               
               
                   
                   
                 QNYALSHNGRWDLG 
                 GACAAACGAGGGCG 
                   
                 GCGGC 
               
               
                   
                   
                 NSELKFYGEKVENKN 
                 AUAAUAGAAAGGGC 
                   
                   
               
               
                   
                   
                 PGNSSPITSESNSIDG 
                 GUGUCCAUCAGAGG 
                   
                   
               
               
                   
                   
                 KYVLPLASVNQFLTF 
                 CCUGGACAGCAGCU 
                   
                   
               
               
                   
                   
                 GGEWRHDKLSDAVS 
                 ACACCCUGAUCCUG 
                   
                   
               
               
                   
                   
                 LTGGSSTKTSASQYA 
                 AUCGACGGCAAGAG 
                   
                   
               
               
                   
                   
                 LFLEDEWRIFEPLALT 
                 AGUGAACAGCCGGA 
                   
                   
               
               
                   
                   
                 TGIRMDDHETYGDH 
                 ACGCCGUGUUCCGG 
                   
                   
               
               
                   
                   
                 WSPRAYLVYNATDT 
                 CACAACGACUUCGA 
                   
                   
               
               
                   
                   
                 LTVKGGWATAFKAP 
                 CCUGAACUGGAUCC 
                   
                   
               
               
                   
                   
                 SLLQLSPDWATNSCR 
                 CCGUGGAUGCCAUC 
                   
                   
               
               
                   
                   
                 GGCRIVGSPDLKPETS 
                 GAGAGGAUCGAAGU 
                   
                   
               
               
                   
                   
                 ESWELGLYYRGEEGI 
                 UGUGCGGGGACCUA 
                   
                   
               
               
                   
                   
                 LEGVEASVTTFRNDV 
                 UGAGCAGCCUGUAC 
                   
                   
               
               
                   
                   
                 DNRISISRTPDVNAAP 
                 GGAUCUGAUGCCCU 
                   
                   
               
               
                   
                   
                 GYSNFVGFETNSRGQ 
                 CGGCGGCGUGGUCA 
                   
                   
               
               
                   
                   
                 RVPVFRYYNVNKARI 
                 ACAUCAUCACCAAG 
                   
                   
               
               
                   
                   
                 QGVETELKVPFNEA 
                 AAGAUCGGCCAGAA 
                   
                   
               
               
                   
                   
                 WKLSLNYTYNDGRD 
                 AUGGCACGGCAGCG 
                   
                   
               
               
                   
                   
                 VSNGGNKPLSDLPFH 
                 UGACCGUGGAUAGC 
                   
                   
               
               
                   
                   
                 TANGTLDWKPAQLE 
                 ACCAUCCAAGAGCA 
                   
                   
               
               
                   
                   
                 DWSFYVSGNYTGRK 
                 CAGAGACAGAGGCG 
                   
                   
               
               
                   
                   
                 RADSATAKTPGGYV 
                 ACACCUACAACGGC 
                   
                   
               
               
                   
                   
                 VWDTGAAWQATKN 
                 CAGUUCUUCACAAG 
                   
                   
               
               
                   
                   
                 VKLRAGVLNVGDKD 
                 CGGCCCUCUGAUUG 
                   
                   
               
               
                   
                   
                 LKRDDYGYTEDGRR 
                 AUGGCGUGCUGGGC 
                   
                   
               
               
                   
                   
                 YFMAVDYRF 
                 AUGAAGGCCUACGG 
                   
                   
               
               
                   
                   
                   
                 AUCUCUGGCCAAGA 
                   
                   
               
               
                   
                   
                   
                 GAGAGAAGGACGAG 
                   
                   
               
               
                   
                   
                   
                 CAGCAGAGCAGCGC 
                   
                   
               
               
                   
                   
                   
                 CACAACAGCCACAG 
                   
                   
               
               
                   
                   
                   
                 GCGAGACACCUAGA 
                   
                   
               
               
                   
                   
                   
                 AUCGAGGGCUUCAC 
                   
                   
               
               
                   
                   
                   
                 CAGCAGAGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 ACGUGGAAUUCGCC 
                   
                   
               
               
                   
                   
                   
                 UGGACACCCAACGA 
                   
                   
               
               
                   
                   
                   
                 GAACCACGAUGUGA 
                   
                   
               
               
                   
                   
                   
                 CAGCCGGCUACGGC 
                   
                   
               
               
                   
                   
                   
                 UUCGACAGACAGGA 
                   
                   
               
               
                   
                   
                   
                 CAGAGAUAGCGACA 
                   
                   
               
               
                   
                   
                   
                 GCCUGGACAAGAAC 
                   
                   
               
               
                   
                   
                   
                 CGGCUGGAAAGACA 
                   
                   
               
               
                   
                   
                   
                 GAACUACGCCCUGA 
                   
                   
               
               
                   
                   
                   
                 GCCACAACGGCAGA 
                   
                   
               
               
                   
                   
                   
                 UGGGACCUGGGAAA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAGCUGAAGU 
                   
                   
               
               
                   
                   
                   
                 UCUACGGCGAGAAG 
                   
                   
               
               
                   
                   
                   
                 GUCGAGAACAAGAA 
                   
                   
               
               
                   
                   
                   
                 CCCCGGCAACAGCA 
                   
                   
               
               
                   
                   
                   
                 GCCCUAUCACCAGC 
                   
                   
               
               
                   
                   
                   
                 GAGAGCAACAGCAU 
                   
                   
               
               
                   
                   
                   
                 CGAUGGCAAAUACG 
                   
                   
               
               
                   
                   
                   
                 UGCUGCCCCUGGCC 
                   
                   
               
               
                   
                   
                   
                 UCCGUGAAUCAGUU 
                   
                   
               
               
                   
                   
                   
                 CCUGACAUUUGGCG 
                   
                   
               
               
                   
                   
                   
                 GAGAGUGGCGGCAC 
                   
                   
               
               
                   
                   
                   
                 GACAAGCUGUCUGA 
                   
                   
               
               
                   
                   
                   
                 UGCCGUUUCUCUGA 
                   
                   
               
               
                   
                   
                   
                 CCGGCGGCAGCAGC 
                   
                   
               
               
                   
                   
                   
                 CUCUCAGUACGCCC 
                   
                   
               
               
                   
                   
                   
                 UGUUCCUGGAAGAU 
                   
                   
               
               
                   
                   
                   
                 GAGUGGCGGAUCUU 
                   
                   
               
               
                   
                   
                   
                 CGAGCCCCUGGCUC 
                   
                   
               
               
                   
                   
                   
                 UGACAACAGGCAUC 
                   
                   
               
               
                   
                   
                   
                 AGAAUGGACGACCA 
                   
                   
               
               
                   
                   
                   
                 CGAGACAUACGGCG 
                   
                   
               
               
                   
                   
                   
                 ACCACUGGUCCCCA 
                   
                   
               
               
                   
                   
                   
                 AGAGCCUACCUGGU 
                   
                   
               
               
                   
                   
                   
                 GUACAACGCCACCG 
                   
                   
               
               
                   
                   
                   
                 ACACACUGACCGUG 
                   
                   
               
               
                   
                   
                   
                 AAAGGCGGAUGGGC 
                   
                   
               
               
                   
                   
                   
                 CACAGCCUUUAAGG 
                   
                   
               
               
                   
                   
                   
                 CUCCUAGUCUGCUG 
                   
                   
               
               
                   
                   
                   
                 CAGCUGAGCCCCGA 
                   
                   
               
               
                   
                   
                   
                 UUGGGCCACCAAUU 
                   
                   
               
               
                   
                   
                   
                 CUUGUAGAGGCGGC 
                   
                   
               
               
                   
                   
                   
                 UGCAGAAUCGUGGG 
                   
                   
               
               
                   
                   
                   
                 CAGCCCUGAUCUGA 
                   
                   
               
               
                   
                   
                   
                 AGCCCGAGACAUCU 
                   
                   
               
               
                   
                   
                   
                 GAGUCUUGGGAGCU 
                   
                   
               
               
                   
                   
                   
                 GGGACUGUACUACA 
                   
                   
               
               
                   
                   
                   
                 GGGGCGAAGAGGGA 
                   
                   
               
               
                   
                   
                   
                 AUCCUGGAAGGCGU 
                   
                   
               
               
                   
                   
                   
                 GGAAGCCAGCGUGA 
                   
                   
               
               
                   
                   
                   
                 CAACCUUCAGAAAC 
                   
                   
               
               
                   
                   
                   
                 GACGUGGACAACCG 
                   
                   
               
               
                   
                   
                   
                 GAUCAGCAUCUCCA 
                   
                   
               
               
                   
                   
                   
                 GAACACCCGACGUG 
                   
                   
               
               
                   
                   
                   
                 AACGCCGCUCCUGG 
                   
                   
               
               
                   
                   
                   
                 CUACUCUAAUUUCG 
                   
                   
               
               
                   
                   
                   
                 UGGGCUUCGAGACA 
                   
                   
               
               
                   
                   
                   
                 AACAGCAGAGGCCA 
                   
                   
               
               
                   
                   
                   
                 GAGGGUGCCCGUGU 
                   
                   
               
               
                   
                   
                   
                 UUCGGUACUACAAC 
                   
                   
               
               
                   
                   
                   
                 GUGAACAAGGCCCG 
                   
                   
               
               
                   
                   
                   
                 GAUCCAGGGCGUCG 
                   
                   
               
               
                   
                   
                   
                 AGACAGAGCUGAAG 
                   
                   
               
               
                   
                   
                   
                 GUGCCCUUUAACGA 
                   
                   
               
               
                   
                   
                   
                 AGCCUGGAAGCUGA 
                   
                   
               
               
                   
                   
                   
                 GCCUGAACUACACA 
                   
                   
               
               
                   
                   
                   
                 UACAACGACGGCCG 
                   
                   
               
               
                   
                   
                   
                 GGACGUGUCCAACG 
                   
                   
               
               
                   
                   
                   
                 GCGGAAACAAACCU 
                   
                   
               
               
                   
                   
                   
                 CUGAGCGACCUGCC 
                   
                   
               
               
                   
                   
                   
                 UUUCCACACCGCCA 
                   
                   
               
               
                   
                   
                   
                 AUGGCACCCUGGAU 
                   
                   
               
               
                   
                   
                   
                 UGGAAGCCUGCUCA 
                   
                   
               
               
                   
                   
                   
                 GCUGGAAGAUUGGA 
                   
                   
               
               
                   
                   
                   
                 GCUUCUACGUGUCC 
                   
                   
               
               
                   
                   
                   
                 GGCAACUACACCGG 
                   
                   
               
               
                   
                   
                   
                 CAGAAAGAGAGCCG 
                   
                   
               
               
                   
                   
                   
                 AUAGCGCCACCGCU 
                   
                   
               
               
                   
                   
                   
                 AAGACACCAGGCGG 
                   
                   
               
               
                   
                   
                   
                 AUACGUCGUGUGGG 
                   
                   
               
               
                   
                   
                   
                 AUACAGGUGCUGCU 
                   
                   
               
               
                   
                   
                   
                 UGGCAGGCCACCAA 
                   
                   
               
               
                   
                   
                   
                 GAACGUGAAACUGA 
                   
                   
               
               
                   
                   
                   
                 GAGCCGGCGUGCUG 
                   
                   
               
               
                   
                   
                   
                 AACGUGGGCGACAA 
                   
                   
               
               
                   
                   
                   
                 AGACCUGAAGAGGG 
                   
                   
               
               
                   
                   
                   
                 ACGACUACGGCUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAGGACGGCAG 
                   
                   
               
               
                   
                   
                   
                 ACGGUACUUCAUGG 
                   
                   
               
               
                   
                   
                   
                 CCGUGGACUACCGG 
                   
                   
               
               
                   
                   
                   
                 UUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 83 
                 84 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 201 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 84, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_cirA_N 
                 MGLQTTKWPSHGAF 
                 AUGGGCCUGCAGAC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 GM_nFLR 
                 FLKSWLIISLGLYSQV 
                 CACAAAGUGGCCUU 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 T2_cHis 
                 SKLLAATDDGETMV 
                 CUCACGGCGCAUUC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 VTASAIEQNLKDAPA 
                 UUUCUGAAGUCCUG 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SISVITQQDLQRRPVQ 
                 GCUGAUCAUCUCCC 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NLKDVLKEVPGVQL 
                 UGGGCCUGUACAGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 TNEGDNRKGVSIRGL 
                 CAGGUGUCCAAACU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 DSSYTLILIDGKRVNS 
                 GCUGGCCGCCACCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 RNAVFRHNDFDLNW 
                 AUGAUGGCGAGACA 
                   
                 UCCCCC 
               
               
                   
                   
                 IPVDAIERIEVVRGPM 
                 AUGGUGGUUACAGC 
                   
                 CAGCCC 
               
               
                   
                   
                 SSLYGSDALGGVVNII 
                 CAGCGCCAUCGAGC 
                   
                 CUCCUC 
               
               
                   
                   
                 TKKIGQKWHGSVTV 
                 AGAACCUGAAAGAU 
                   
                 CCCUUC 
               
               
                   
                   
                 DSTIQEHRDRGDTYN 
                 GCCCCUGCCAGCAU 
                   
                 CUGCAC 
               
               
                   
                   
                 GQFFTSGPLIDGVLG 
                 CAGCGUGAUCACCC 
                   
                 CCGUAC 
               
               
                   
                   
                 MKAYGSLAKREKDE 
                 AGCAGGAUCUGCAG 
                   
                 CCCCGU 
               
               
                   
                   
                 QQSSATTATGETPRIE 
                 AGAAGGCCCGUGCA 
                   
                 GGUCUU 
               
               
                   
                   
                 GFTSRDGNVEFAWTP 
                 GAAUCUGAAGGACG 
                   
                 UGAAUA 
               
               
                   
                   
                 NENHDVTAGYGFDR 
                 UGCUGAAAGAGGUG 
                   
                 AAGUCU 
               
               
                   
                   
                 QDRDSDSLDKNRLER 
                 CCCGGCGUCCAGCU 
                   
                 GAGUGG 
               
               
                   
                   
                 QNYALSHNGRWDLG 
                 GACAAACGAGGGCG 
                   
                 GCGGC 
               
               
                   
                   
                 NSELKFYGEKVENKN 
                 AUAAUAGAAAGGGC 
                   
                   
               
               
                   
                   
                 PGNSSPITSESNSIDG 
                 GUGUCCAUCAGAGG 
                   
                   
               
               
                   
                   
                 KYVLPLASVNQFLTF 
                 CCUGGACAGCAGCU 
                   
                   
               
               
                   
                   
                 GGEWRHDKLSDAVS 
                 ACACCCUGAUCCUG 
                   
                   
               
               
                   
                   
                 LTGGSSTKTSASQYA 
                 AUCGACGGCAAGAG 
                   
                   
               
               
                   
                   
                 LFLEDEWRIFEPLALT 
                 AGUGAACAGCCGGA 
                   
                   
               
               
                   
                   
                 TGIRMDDHETYGDH 
                 ACGCCGUGUUCCGG 
                   
                   
               
               
                   
                   
                 WSPRAYLVYNAADT 
                 CACAACGACUUCGA 
                   
                   
               
               
                   
                   
                 LTVKGGWATAFKAP 
                 CCUGAACUGGAUCC 
                   
                   
               
               
                   
                   
                 SLLQLSPDWATNSCR 
                 CCGUGGAUGCCAUC 
                   
                   
               
               
                   
                   
                 GGCRIVGSPDLKPETS 
                 GAGAGGAUCGAAGU 
                   
                   
               
               
                   
                   
                 ESWELGLYYRGEEGI 
                 UGUGCGGGGACCUA 
                   
                   
               
               
                   
                   
                 LEGVEASVTTFRNDV 
                 UGAGCAGCCUGUAC 
                   
                   
               
               
                   
                   
                 DNRISISRTPDVNAAP 
                 GGAUCUGAUGCCCU 
                   
                   
               
               
                   
                   
                 GYSNFVGFETNSRGQ 
                 CGGCGGCGUGGUCA 
                   
                   
               
               
                   
                   
                 RVPVFRYYNVNKARI 
                 ACAUCAUCACCAAG 
                   
                   
               
               
                   
                   
                 QGVETELKVPFNEA 
                 AAGAUCGGCCAGAA 
                   
                   
               
               
                   
                   
                 WKLSLNYAYNDGRD 
                 AUGGCACGGCAGCG 
                   
                   
               
               
                   
                   
                 VSNGGNKPLSDLPFH 
                 UGACCGUGGAUAGC 
                   
                   
               
               
                   
                   
                 TANGALDWKPAQLE 
                 ACCAUCCAAGAGCA 
                   
                   
               
               
                   
                   
                 DWSFYVSGNYAGRK 
                 CAGAGACAGAGGCG 
                   
                   
               
               
                   
                   
                 RADSATAKTPGGYV 
                 ACACCUACAACGGC 
                   
                   
               
               
                   
                   
                 VWDTGAAWQATKN 
                 CAGUUCUUCACAAG 
                   
                   
               
               
                   
                   
                 VKLRAGVLNVGDKD 
                 CGGCCCUCUGAUUG 
                   
                   
               
               
                   
                   
                 LKRDDYGYTEDGRR 
                 AUGGCGUGCUGGGC 
                   
                   
               
               
                   
                   
                 YFMAVDYRFHHHHH 
                 AUGAAGGCCUACGG 
                   
                   
               
               
                   
                   
                 H 
                 AUCUCUGGCCAAGA 
                   
                   
               
               
                   
                   
                   
                 GAGAGAAGGACGAG 
                   
                   
               
               
                   
                   
                   
                 CAGCAGAGCAGCGC 
                   
                   
               
               
                   
                   
                   
                 CACAACAGCCACAG 
                   
                   
               
               
                   
                   
                   
                 GCGAGACACCUAGA 
                   
                   
               
               
                   
                   
                   
                 AUCGAGGGCUUCAC 
                   
                   
               
               
                   
                   
                   
                 CAGCAGAGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 ACGUGGAAUUCGCC 
                   
                   
               
               
                   
                   
                   
                 UGGACACCCAACGA 
                   
                   
               
               
                   
                   
                   
                 GAACCACGAUGUGA 
                   
                   
               
               
                   
                   
                   
                 CAGCCGGCUACGGC 
                   
                   
               
               
                   
                   
                   
                 UUCGACAGACAGGA 
                   
                   
               
               
                   
                   
                   
                 CAGAGAUAGCGACA 
                   
                   
               
               
                   
                   
                   
                 GCCUGGACAAGAAC 
                   
                   
               
               
                   
                   
                   
                 CGGCUGGAAAGACA 
                   
                   
               
               
                   
                   
                   
                 GAACUACGCCCUGA 
                   
                   
               
               
                   
                   
                   
                 GCCACAACGGCAGA 
                   
                   
               
               
                   
                   
                   
                 UGGGACCUGGGAAA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAGCUGAAGU 
                   
                   
               
               
                   
                   
                   
                 UCUACGGCGAGAAG 
                   
                   
               
               
                   
                   
                   
                 GUCGAGAACAAGAA 
                   
                   
               
               
                   
                   
                   
                 CCCCGGCAACAGCA 
                   
                   
               
               
                   
                   
                   
                 GCCCUAUCACCAGC 
                   
                   
               
               
                   
                   
                   
                 GAGAGCAACAGCAU 
                   
                   
               
               
                   
                   
                   
                 CGAUGGCAAAUACG 
                   
                   
               
               
                   
                   
                   
                 UGCUGCCCCUGGCC 
                   
                   
               
               
                   
                   
                   
                 UCCGUGAAUCAGUU 
                   
                   
               
               
                   
                   
                   
                 CCUGACAUUUGGCG 
                   
                   
               
               
                   
                   
                   
                 GAGAGUGGCGGCAC 
                   
                   
               
               
                   
                   
                   
                 GACAAGCUGUCUGA 
                   
                   
               
               
                   
                   
                   
                 UGCCGUUUCUCUGA 
                   
                   
               
               
                   
                   
                   
                 CCGGCGGCAGCAGC 
                   
                   
               
               
                   
                   
                   
                 ACAAAGACAAGCGC 
                   
                   
               
               
                   
                   
                   
                 CUCUCAGUACGCCC 
                   
                   
               
               
                   
                   
                   
                 UGUUCCUGGAAGAU 
                   
                   
               
               
                   
                   
                   
                 GAGUGGCGGAUCUU 
                   
                   
               
               
                   
                   
                   
                 CGAGCCCCUGGCUC 
                   
                   
               
               
                   
                   
                   
                 UGACAACAGGCAUC 
                   
                   
               
               
                   
                   
                   
                 AGAAUGGACGACCA 
                   
                   
               
               
                   
                   
                   
                 CGAGACAUACGGCG 
                   
                   
               
               
                   
                   
                   
                 ACCACUGGUCCCCA 
                   
                   
               
               
                   
                   
                   
                 AGAGCCUACCUGGU 
                   
                   
               
               
                   
                   
                   
                 GUACAACGCCGCCG 
                   
                   
               
               
                   
                   
                   
                 ACACACUGACCGUG 
                   
                   
               
               
                   
                   
                   
                 AAAGGCGGAUGGGC 
                   
                   
               
               
                   
                   
                   
                 CACAGCCUUUAAGG 
                   
                   
               
               
                   
                   
                   
                 CUCCUAGUCUGCUG 
                   
                   
               
               
                   
                   
                   
                 CAGCUGAGCCCCGA 
                   
                   
               
               
                   
                   
                   
                 UUGGGCCACCAAUU 
                   
                   
               
               
                   
                   
                   
                 CUUGUAGAGGCGGC 
                   
                   
               
               
                   
                   
                   
                 UGCAGAAUCGUGGG 
                   
                   
               
               
                   
                   
                   
                 CAGCCCUGAUCUGA 
                   
                   
               
               
                   
                   
                   
                 AGCCCGAGACAUCU 
                   
                   
               
               
                   
                   
                   
                 GAGUCUUGGGAGCU 
                   
                   
               
               
                   
                   
                   
                 GGGACUGUACUACA 
                   
                   
               
               
                   
                   
                   
                 GGGGCGAAGAGGGA 
                   
                   
               
               
                   
                   
                   
                 AUCCUGGAAGGCGU 
                   
                   
               
               
                   
                   
                   
                 GGAAGCCAGCGUGA 
                   
                   
               
               
                   
                   
                   
                 CAACCUUCAGAAAC 
                   
                   
               
               
                   
                   
                   
                 GACGUGGACAACCG 
                   
                   
               
               
                   
                   
                   
                 GAUCAGCAUCUCCA 
                   
                   
               
               
                   
                   
                   
                 GAACACCCGACGUG 
                   
                   
               
               
                   
                   
                   
                 AACGCCGCUCCUGG 
                   
                   
               
               
                   
                   
                   
                 CUACUCUAAUUUCG 
                   
                   
               
               
                   
                   
                   
                 UGGGCUUCGAGACA 
                   
                   
               
               
                   
                   
                   
                 AACAGCAGAGGCCA 
                   
                   
               
               
                   
                   
                   
                 GAGGGUGCCCGUGU 
                   
                   
               
               
                   
                   
                   
                 UUCGGUACUACAAC 
                   
                   
               
               
                   
                   
                   
                 GUGAACAAGGCCCG 
                   
                   
               
               
                   
                   
                   
                 GAUCCAGGGCGUCG 
                   
                   
               
               
                   
                   
                   
                 AGACAGAGCUGAAG 
                   
                   
               
               
                   
                   
                   
                 GUGCCCUUUAACGA 
                   
                   
               
               
                   
                   
                   
                 AGCCUGGAAGCUGA 
                   
                   
               
               
                   
                   
                   
                 GCCUGAACUACGCA 
                   
                   
               
               
                   
                   
                   
                 UACAACGACGGCCG 
                   
                   
               
               
                   
                   
                   
                 GGACGUGUCCAACG 
                   
                   
               
               
                   
                   
                   
                 GCGGAAACAAACCU 
                   
                   
               
               
                   
                   
                   
                 CUGAGCGACCUGCC 
                   
                   
               
               
                   
                   
                   
                 UUUCCACACCGCCA 
                   
                   
               
               
                   
                   
                   
                 AUGGCGCCCUGGAU 
                   
                   
               
               
                   
                   
                   
                 UGGAAGCCUGCUCA 
                   
                   
               
               
                   
                   
                   
                 GCUGGAAGAUUGGA 
                   
                   
               
               
                   
                   
                   
                 GCUUCUACGUGUCC 
                   
                   
               
               
                   
                   
                   
                 GGCAACUACGCCGG 
                   
                   
               
               
                   
                   
                   
                 CAGAAAGAGAGCCG 
                   
                   
               
               
                   
                   
                   
                 AUAGCGCCACCGCU 
                   
                   
               
               
                   
                   
                   
                 AAGACACCAGGCGG 
                   
                   
               
               
                   
                   
                   
                 AUACGUCGUGUGGG 
                   
                   
               
               
                   
                   
                   
                 AUACAGGUGCUGCU 
                   
                   
               
               
                   
                   
                   
                 UGGCAGGCCACCAA 
                   
                   
               
               
                   
                   
                   
                 GAACGUGAAACUGA 
                   
                   
               
               
                   
                   
                   
                 GAGCCGGCGUGCUG 
                   
                   
               
               
                   
                   
                   
                 AACGUGGGCGACAA 
                   
                   
               
               
                   
                   
                   
                 AGACCUGAAGAGGG 
                   
                   
               
               
                   
                   
                   
                 ACGACUACGGCUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAGGACGGCAG 
                   
                   
               
               
                   
                   
                   
                 ACGGUACUUCAUGG 
                   
                   
               
               
                   
                   
                   
                 CCGUGGACUACCGG 
                   
                   
               
               
                   
                   
                   
                 UUCCACCACCACCA 
                   
                   
               
               
                   
                   
                   
                 UCACCAU 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 85 
                 86 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 202 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 86, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_cirA_N 
                 MGLQTTKWPSHGAF 
                 AUGGGCCUGCAGAC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 GM_nFLR 
                 FLKSWLIISLGLYSQV 
                 CACAAAGUGGCCUU 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 T2 
                 SKLLAATDDGETMV 
                 CUCACGGCGCAUUC 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 VTASAIEQNLKDAPA 
                 UUUCUGAAGUCCUG 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SISVITQQDLQRRPVQ 
                 GCUGAUCAUCUCCC 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NLKDVLKEVPGVQL 
                 UGGGCCUGUACAGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 TNEGDNRKGVSIRGL 
                 CAGGUGUCCAAACU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 DSSYTLILIDGKRVNS 
                 GCUGGCCGCCACCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 RNAVFRHNDFDLNW 
                 AUGAUGGCGAGACA 
                   
                 UCCCCC 
               
               
                   
                   
                 IPVDAIERIEVVRGPM 
                 AUGGUGGUUACAGC 
                   
                 CAGCCC 
               
               
                   
                   
                 SSLYGSDALGGVVNII 
                 CAGCGCCAUCGAGC 
                   
                 CUCCUC 
               
               
                   
                   
                 TKKIGQKWHGSVTV 
                 AGAACCUGAAAGAU 
                   
                 CCCUUC 
               
               
                   
                   
                 DSTIQEHRDRGDTYN 
                 GCCCCUGCCAGCAU 
                   
                 CUGCAC 
               
               
                   
                   
                 GQFFTSGPLIDGVLG 
                 CAGCGUGAUCACCC 
                   
                 CCGUAC 
               
               
                   
                   
                 MKAYGSLAKREKDE 
                 AGCAGGAUCUGCAG 
                   
                 CCCCGU 
               
               
                   
                   
                 QQSSATTATGETPRIE 
                 AGAAGGCCCGUGCA 
                   
                 GGUCUU 
               
               
                   
                   
                 GFTSRDGNVEFAWTP 
                 GAAUCUGAAGGACG 
                   
                 UGAAUA 
               
               
                   
                   
                 NENHDVTAGYGFDR 
                 UGCUGAAAGAGGUG 
                   
                 AAGUCU 
               
               
                   
                   
                 QDRDSDSLDKNRLER 
                 CCCGGCGUCCAGCU 
                   
                 GAGUGG 
               
               
                   
                   
                 QNYALSHNGRWDLG 
                 GACAAACGAGGGCG 
                   
                 GCGGC 
               
               
                   
                   
                 NSELKFYGEKVENKN 
                 AUAAUAGAAAGGGC 
                   
                   
               
               
                   
                   
                 PGNSSPITSESNSIDG 
                 GUGUCCAUCAGAGG 
                   
                   
               
               
                   
                   
                 KYVLPLASVNQFLTF 
                 CCUGGACAGCAGCU 
                   
                   
               
               
                   
                   
                 GGEWRHDKLSDAVS 
                 ACACCCUGAUCCUG 
                   
                   
               
               
                   
                   
                 LTGGSSTKTSASQYA 
                 AUCGACGGCAAGAG 
                   
                   
               
               
                   
                   
                 LFLEDEWRIFEPLALT 
                 AGUGAACAGCCGGA 
                   
                   
               
               
                   
                   
                 TGIRMDDHETYGDH 
                 ACGCCGUGUUCCGG 
                   
                   
               
               
                   
                   
                 WSPRAYLVYNAADT 
                 CACAACGACUUCGA 
                   
                   
               
               
                   
                   
                 LTVKGGWATAFKAP 
                 CCUGAACUGGAUCC 
                   
                   
               
               
                   
                   
                 SLLQLSPDWATNSCR 
                 CCGUGGAUGCCAUC 
                   
                   
               
               
                   
                   
                 GGCRIVGSPDLKPETS 
                 GAGAGGAUCGAAGU 
                   
                   
               
               
                   
                   
                 ESWELGLYYRGEEGI 
                 UGUGCGGGGACCUA 
                   
                   
               
               
                   
                   
                 LEGVEASVTTFRNDV 
                 UGAGCAGCCUGUAC 
                   
                   
               
               
                   
                   
                 DNRISISRTPDVNAAP 
                 GGAUCUGAUGCCCU 
                   
                   
               
               
                   
                   
                 GYSNFVGFETNSRGQ 
                 CGGCGGCGUGGUCA 
                   
                   
               
               
                   
                   
                 RVPVFRYYNVNKARI 
                 ACAUCAUCACCAAG 
                   
                   
               
               
                   
                   
                 QGVETELKVPFNEA 
                 AAGAUCGGCCAGAA 
                   
                   
               
               
                   
                   
                 WKLSLNYAYNDGRD 
                 AUGGCACGGCAGCG 
                   
                   
               
               
                   
                   
                 VSNGGNKPLSDLPFH 
                 UGACCGUGGAUAGC 
                   
                   
               
               
                   
                   
                 TANGALDWKPAQLE 
                 ACCAUCCAAGAGCA 
                   
                   
               
               
                   
                   
                 DWSFYVSGNYAGRK 
                 CAGAGACAGAGGCG 
                   
                   
               
               
                   
                   
                 RADSATAKTPGGYV 
                 ACACCUACAACGGC 
                   
                   
               
               
                   
                   
                 VWDTGAAWQATKN 
                 CAGUUCUUCACAAG 
                   
                   
               
               
                   
                   
                 VKLRAGVLNVGDKD 
                 CGGCCCUCUGAUUG 
                   
                   
               
               
                   
                   
                 LKRDDYGYTEDGRR 
                 AUGGCGUGCUGGGC 
                   
                   
               
               
                   
                   
                 YFMAVDYRF 
                 AUGAAGGCCUACGG 
                   
                   
               
               
                   
                   
                   
                 AUCUCUGGCCAAGA 
                   
                   
               
               
                   
                   
                   
                 GAGAGAAGGACGAG 
                   
                   
               
               
                   
                   
                   
                 CAGCAGAGCAGCGC 
                   
                   
               
               
                   
                   
                   
                 CACAACAGCCACAG 
                   
                   
               
               
                   
                   
                   
                 GCGAGACACCUAGA 
                   
                   
               
               
                   
                   
                   
                 AUCGAGGGCUUCAC 
                   
                   
               
               
                   
                   
                   
                 CAGCAGAGAUGGCA 
                   
                   
               
               
                   
                   
                   
                 ACGUGGAAUUCGCC 
                   
                   
               
               
                   
                   
                   
                 UGGACACCCAACGA 
                   
                   
               
               
                   
                   
                   
                 GAACCACGAUGUGA 
                   
                   
               
               
                   
                   
                   
                 CAGCCGGCUACGGC 
                   
                   
               
               
                   
                   
                   
                 UUCGACAGACAGGA 
                   
                   
               
               
                   
                   
                   
                 CAGAGAUAGCGACA 
                   
                   
               
               
                   
                   
                   
                 GCCUGGACAAGAAC 
                   
                   
               
               
                   
                   
                   
                 CGGCUGGAAAGACA 
                   
                   
               
               
                   
                   
                   
                 GAACUACGCCCUGA 
                   
                   
               
               
                   
                   
                   
                 GCCACAACGGCAGA 
                   
                   
               
               
                   
                   
                   
                 UGGGACCUGGGAAA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAGCUGAAGU 
                   
                   
               
               
                   
                   
                   
                 UCUACGGCGAGAAG 
                   
                   
               
               
                   
                   
                   
                 GUCGAGAACAAGAA 
                   
                   
               
               
                   
                   
                   
                 CCCCGGCAACAGCA 
                   
                   
               
               
                   
                   
                   
                 GCCCUAUCACCAGC 
                   
                   
               
               
                   
                   
                   
                 GAGAGCAACAGCAU 
                   
                   
               
               
                   
                   
                   
                 CGAUGGCAAAUACG 
                   
                   
               
               
                   
                   
                   
                 UGCUGCCCCUGGCC 
                   
                   
               
               
                   
                   
                   
                 UCCGUGAAUCAGUU 
                   
                   
               
               
                   
                   
                   
                 CCUGACAUUUGGCG 
                   
                   
               
               
                   
                   
                   
                 GAGAGUGGCGGCAC 
                   
                   
               
               
                   
                   
                   
                 GACAAGCUGUCUGA 
                   
                   
               
               
                   
                   
                   
                 UGCCGUUUCUCUGA 
                   
                   
               
               
                   
                   
                   
                 CCGGCGGCAGCAGC 
                   
                   
               
               
                   
                   
                   
                 ACAAAGACAAGCGC 
                   
                   
               
               
                   
                   
                   
                 CUCUCAGUACGCCC 
                   
                   
               
               
                   
                   
                   
                 UGUUCCUGGAAGAU 
                   
                   
               
               
                   
                   
                   
                 GAGUGGCGGAUCUU 
                   
                   
               
               
                   
                   
                   
                 CGAGCCCCUGGCUC 
                   
                   
               
               
                   
                   
                   
                 UGACAACAGGCAUC 
                   
                   
               
               
                   
                   
                   
                 AGAAUGGACGACCA 
                   
                   
               
               
                   
                   
                   
                 CGAGACAUACGGCG 
                   
                   
               
               
                   
                   
                   
                 ACCACUGGUCCCCA 
                   
                   
               
               
                   
                   
                   
                 AGAGCCUACCUGGU 
                   
                   
               
               
                   
                   
                   
                 GUACAACGCCGCCG 
                   
                   
               
               
                   
                   
                   
                 ACACACUGACCGUG 
                   
                   
               
               
                   
                   
                   
                 AAAGGCGGAUGGGC 
                   
                   
               
               
                   
                   
                   
                 CACAGCCUUUAAGG 
                   
                   
               
               
                   
                   
                   
                 CUCCUAGUCUGCUG 
                   
                   
               
               
                   
                   
                   
                 CAGCUGAGCCCCGA 
                   
                   
               
               
                   
                   
                   
                 UUGGGCCACCAAUU 
                   
                   
               
               
                   
                   
                   
                 CUUGUAGAGGCGGC 
                   
                   
               
               
                   
                   
                   
                 UGCAGAAUCGUGGG 
                   
                   
               
               
                   
                   
                   
                 CAGCCCUGAUCUGA 
                   
                   
               
               
                   
                   
                   
                 AGCCCGAGACAUCU 
                   
                   
               
               
                   
                   
                   
                 GAGUCUUGGGAGCU 
                   
                   
               
               
                   
                   
                   
                 GGGACUGUACUACA 
                   
                   
               
               
                   
                   
                   
                 GGGGCGAAGAGGGA 
                   
                   
               
               
                   
                   
                   
                 AUCCUGGAAGGCGU 
                   
                   
               
               
                   
                   
                   
                 GGAAGCCAGCGUGA 
                   
                   
               
               
                   
                   
                   
                 CAACCUUCAGAAAC 
                   
                   
               
               
                   
                   
                   
                 GACGUGGACAACCG 
                   
                   
               
               
                   
                   
                   
                 GAUCAGCAUCUCCA 
                   
                   
               
               
                   
                   
                   
                 GAACACCCGACGUG 
                   
                   
               
               
                   
                   
                   
                 AACGCCGCUCCUGG 
                   
                   
               
               
                   
                   
                   
                 CUACUCUAAUUUCG 
                   
                   
               
               
                   
                   
                   
                 UGGGCUUCGAGACA 
                   
                   
               
               
                   
                   
                   
                 AACAGCAGAGGCCA 
                   
                   
               
               
                   
                   
                   
                 GAGGGUGCCCGUGU 
                   
                   
               
               
                   
                   
                   
                 UUCGGUACUACAAC 
                   
                   
               
               
                   
                   
                   
                 GUGAACAAGGCCCG 
                   
                   
               
               
                   
                   
                   
                 GAUCCAGGGCGUCG 
                   
                   
               
               
                   
                   
                   
                 AGACAGAGCUGAAG 
                   
                   
               
               
                   
                   
                   
                 GUGCCCUUUAACGA 
                   
                   
               
               
                   
                   
                   
                 AGCCUGGAAGCUGA 
                   
                   
               
               
                   
                   
                   
                 GCCUGAACUACGCA 
                   
                   
               
               
                   
                   
                   
                 UACAACGACGGCCG 
                   
                   
               
               
                   
                   
                   
                 GGACGUGUCCAACG 
                   
                   
               
               
                   
                   
                   
                 GCGGAAACAAACCU 
                   
                   
               
               
                   
                   
                   
                 CUGAGCGACCUGCC 
                   
                   
               
               
                   
                   
                   
                 UUUCCACACCGCCA 
                   
                   
               
               
                   
                   
                   
                 AUGGCGCCCUGGAU 
                   
                   
               
               
                   
                   
                   
                 UGGAAGCCUGCUCA 
                   
                   
               
               
                   
                   
                   
                 GCUGGAAGAUUGGA 
                   
                   
               
               
                   
                   
                   
                 GCUUCUACGUGUCC 
                   
                   
               
               
                   
                   
                   
                 GGCAACUACGCCGG 
                   
                   
               
               
                   
                   
                   
                 CAGAAAGAGAGCCG 
                   
                   
               
               
                   
                   
                   
                 AUAGCGCCACCGCU 
                   
                   
               
               
                   
                   
                   
                 AAGACACCAGGCGG 
                   
                   
               
               
                   
                   
                   
                 AUACGUCGUGUGGG 
                   
                   
               
               
                   
                   
                   
                 AUACAGGUGCUGCU 
                   
                   
               
               
                   
                   
                   
                 UGGCAGGCCACCAA 
                   
                   
               
               
                   
                   
                   
                 GAACGUGAAACUGA 
                   
                   
               
               
                   
                   
                   
                 GAGCCGGCGUGCUG 
                   
                   
               
               
                   
                   
                   
                 AACGUGGGCGACAA 
                   
                   
               
               
                   
                   
                   
                 AGACCUGAAGAGGG 
                   
                   
               
               
                   
                   
                   
                 ACGACUACGGCUAC 
                   
                   
               
               
                   
                   
                   
                 ACCGAGGACGGCAG 
                   
                   
               
               
                   
                   
                   
                 ACGGUACUUCAUGG 
                   
                   
               
               
                   
                   
                   
                 CCGUGGACUACCGG 
                   
                   
               
               
                   
                   
                   
                 UUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 87 
                 88 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 203 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 88, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_ViMim 
                 MDSKGSSQKGSRLLL 
                 AUGGAUAGCAAGGG 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 o_Lumazin 
                 LLVVSNLLLPQGVVG 
                 CAGCAGCCAGAAGG 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 e_cHis 
                 TSHHDSHGLHRVGSG 
                 GCUCCAGACUGCUG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 SAMQIYEGKLTAEGL 
                 CUGCUUCUGGUGGU 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 RFGIVASRFNHALVD 
                 GUCCAACCUGCUUC 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 RLVEGAIDAIVRHGG 
                 UGCCUCAAGGCGUU 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 REEDITLVRVPGSWEI 
                 GUGGGCACGAGCCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 PVAAGELARKENISA 
                 CCACGACAGCCACG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 VIAIGVLIRGATPHFD 
                 GGUUGCACAGGGUG 
                   
                 UCCCCC 
               
               
                   
                   
                 YIASEVSKGLADLSL 
                 GGAAGCGGCAGCGC 
                   
                 CAGCCC 
               
               
                   
                   
                 ELRKPITFGVITADTL 
                 CAUGCAGAUCUACG 
                   
                 CUCCUC 
               
               
                   
                   
                 EQAIERAGTKHGNKG 
                 AGGGAAAGCUGACC 
                   
                 CCCUUC 
               
               
                   
                   
                 WEAALSAIEMANLFK 
                 GCCGAGGGCCUGAG 
                   
                 CUGCAC 
               
               
                   
                   
                 SLRGGLVPRGSHHHH 
                 AUUUGGAAUCGUGG 
                   
                 CCGUAC 
               
               
                   
                   
                 HHSAWSHPQFEK 
                 CCAGCCGGUUCAAU 
                   
                 CCCCGU 
               
               
                   
                   
                   
                 CACGCCCUGGUGGA 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 UAGACUGGUGGAAG 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 GCGCCAUCGAUGCC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 AUUGUCAGACACGG 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CGGCAGAGAAGAGG 
                   
                 GCGGC 
               
               
                   
                   
                   
                 ACAUCACCCUCGUU 
                   
                   
               
               
                   
                   
                   
                 AGAGUGCCCGGCUC 
                   
                   
               
               
                   
                   
                   
                 UUGGGAGAUUCCUG 
                   
                   
               
               
                   
                   
                   
                 UGGCUGCUGGCGAG 
                   
                   
               
               
                   
                   
                   
                 CUGGCCCGGAAAGA 
                   
                   
               
               
                   
                   
                   
                 GAAUAUCUCUGCCG 
                   
                   
               
               
                   
                   
                   
                 UUAUCGCCAUCGGC 
                   
                   
               
               
                   
                   
                   
                 GUGCUGAUCAGAGG 
                   
                   
               
               
                   
                   
                   
                 CGCCACACCUCACU 
                   
                   
               
               
                   
                   
                   
                 UCGACUAUAUCGCC 
                   
                   
               
               
                   
                   
                   
                 AGCGAGGUGUCCAA 
                   
                   
               
               
                   
                   
                   
                 AGGCCUGGCCGAUC 
                   
                   
               
               
                   
                   
                   
                 UGAGCCUGGAACUG 
                   
                   
               
               
                   
                   
                   
                 AGAAAGCCCAUCAC 
                   
                   
               
               
                   
                   
                   
                 CUUCGGCGUGAUCA 
                   
                   
               
               
                   
                   
                   
                 CCGCUGACACACUG 
                   
                   
               
               
                   
                   
                   
                 GAACAGGCCAUUGA 
                   
                   
               
               
                   
                   
                   
                 GAGAGCCGGCACCA 
                   
                   
               
               
                   
                   
                   
                 AGCACGGCAACAAA 
                   
                   
               
               
                   
                   
                   
                 GGAUGGGAAGCCGC 
                   
                   
               
               
                   
                   
                   
                 UCUGUCCGCCAUCG 
                   
                   
               
               
                   
                   
                   
                 AGAUGGCCAACCUG 
                   
                   
               
               
                   
                   
                   
                 UUCAAGAGCCUGAG 
                   
                   
               
               
                   
                   
                   
                 AGGCGGCCUGGUGC 
                   
                   
               
               
                   
                   
                   
                 CUAGAGGAUCUCAC 
                   
                   
               
               
                   
                   
                   
                 CACCACCAUCACCA 
                   
                   
               
               
                   
                   
                   
                 CAGCGCUUGGAGCC 
                   
                   
               
               
                   
                   
                   
                 AUCCUCAGUUCGAG 
                   
                   
               
               
                   
                   
                   
                 AAG 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 89 
                 90 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 204 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 90, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_FepA_n 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACACCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 IgK_cHis 
                   PDTTG EEKTDSAALT 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 NEDTIVVTAAQQNLQ 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 APGVSTITADEIRKNP 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 PARDVSEIIRTMPGV 
                 CGGGGAGGAGAAGA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NLTGNSTSGQRGNNR 
                 CCGACAGCGCAGCC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 QIDIRGMGPENTLILI 
                 CUGACCAACGAGGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 DGKPVTSRNSVRLG 
                 CACCAUCGUGGUGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 WRGERDTRGDTAWV 
                 CCGCCGCUCAGCAG 
                   
                 UCCCCC 
               
               
                   
                   
                 PPEMIERIEVLRGPAA 
                 AACCUGCAGGCGCC 
                   
                 CAGCCC 
               
               
                   
                   
                 ARYGNGAAGGVVNII 
                 CGGCGUGAGCACCA 
                   
                 CUCCUC 
               
               
                   
                   
                 TKKGGSEWHGSWNT 
                 UCACCGCCGACGAG 
                   
                 CCCUUC 
               
               
                   
                   
                 YFNAPEHKDEGATK 
                 AUCAGAAAGAACCC 
                   
                 CUGCAC 
               
               
                   
                   
                 RTNFSLNGPLGGDFS 
                 UCCUGCCAGAGACG 
                   
                 CCGUAC 
               
               
                   
                   
                 FRLYGNLDKTQADA 
                 UGAGCGAGAUCAUC 
                   
                 CCCCGU 
               
               
                   
                   
                 RNINQGHQSERTGSY 
                 AGAACCAUGCCUGG 
                   
                 GGUCUU 
               
               
                   
                   
                 ADTLPAGREGVINKD 
                 CGUGAACCUGACCG 
                   
                 UGAAUA 
               
               
                   
                   
                 INGVVRWDFAPLQSL 
                 GCAACAGCACCAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 ELEAGYSRQGNLYA 
                 GGCCAGAGAGGCAA 
                   
                 GAGUGG 
               
               
                   
                   
                 GDTQNTNTNQLVKD 
                 CAACAGACAGAUCG 
                   
                 GCGGC 
               
               
                   
                   
                 NYGKETNRLYRQNY 
                 ACAUCAGAGGCAUG 
                   
                   
               
               
                   
                   
                 SLTWNGGWDNGVTT 
                 GGCCCUGAGAACAC 
                   
                   
               
               
                   
                   
                 SNWVQYEHTRNSRM 
                 CCUGAUCCUGAUCG 
                   
                   
               
               
                   
                   
                 PEGLAGGTEGIFDPK 
                 ACGGCAAGCCCGUG 
                   
                   
               
               
                   
                   
                 ASQKYADADLNDVT 
                 ACCAGCAGGAAUAG 
                   
                   
               
               
                   
                   
                 LHSEVSLPFDLLVNQ 
                 CGUGAGACUGGGCU 
                   
                   
               
               
                   
                   
                 NLTLGTEWAQQRMK 
                 GGAGAGGGGAGCGC 
                   
                   
               
               
                   
                   
                 DQLSNSQTFMGGNIP 
                 GACACAAGGGGCGA 
                   
                   
               
               
                   
                   
                 GYSSTNRSPYSKAEIF 
                 UACCGCCUGGGUGC 
                   
                   
               
               
                   
                   
                 SLFAENNMELTDSTM 
                 CUCCUGAGAUGAUC 
                   
                   
               
               
                   
                   
                 LTPGIRFDHHSIVGDN 
                 GAGAGAAUCGAGGU 
                   
                   
               
               
                   
                   
                 WSPSLNLSQGLGDDF 
                 GCUGAGAGGCCCUG 
                   
                   
               
               
                   
                   
                 TLKMGIARAYKAPSL 
                 CCGCCGCCAGAUAC 
                   
                   
               
               
                   
                   
                 YQTNPNYILYSKGQG 
                 GGGAACGGAGCCGC 
                   
                   
               
               
                   
                   
                 CYATGAGTGIGCYM 
                 CGGCGGCGUGGUGA 
                   
                   
               
               
                   
                   
                 MGNDDLKAETSINKE 
                 ACAUCAUCACCAAG 
                   
                   
               
               
                   
                   
                 IGLEFKRDGWLAGVT 
                 AAGGGCGGCAGCGA 
                   
                   
               
               
                   
                   
                 WFRNDYRNKIEAGT 
                 GUGGCACGGCAGCU 
                   
                   
               
               
                   
                   
                 VPLQRINNGKTDVYQ 
                 GGAACACCUACUUC 
                   
                   
               
               
                   
                   
                 WENVPKAVVEGLEG 
                 AACGCCCCUGAGCA 
                   
                   
               
               
                   
                   
                 TLNVPVSDTVNWTN 
                 CAAGGACGAGGGCG 
                   
                   
               
               
                   
                   
                 NVTYMLQSKNKETG 
                 CCACCAAGAGAACC 
                   
                   
               
               
                   
                   
                 ERLSIIPQYTLNSTLS 
                 AACUUCAGCCUGAA 
                   
                   
               
               
                   
                   
                 WQVRQDVSLQSTFT 
                 CGGCCCUCUGGGCG 
                   
                   
               
               
                   
                   
                 WYGKQEPKKYDYQG 
                 GCGACUUCAGCUUC 
                   
                   
               
               
                   
                   
                 NPVTGTDKQAVSPYS 
                 AGACUGUACGGCAA 
                   
                   
               
               
                   
                   
                 IVGLSATWDVTKNVS 
                 CCUGGACAAGACCC 
                   
                   
               
               
                   
                   
                 LTGGVDNLFDKRLW 
                 AGGCCGACGCCAGA 
                   
                   
               
               
                   
                   
                 REGNAQTVRDTQTG 
                 AACAUCAACCAGGG 
                   
                   
               
               
                   
                   
                 GRTWYMSINTHFHH 
                 GAACCGGCAGCUAC 
                   
                   
               
               
                   
                   
                 HHHH 
                 GCCGACACCCUGCC 
                   
                   
               
               
                   
                   
                   
                 UGCCGGCAGAGAGG 
                   
                   
               
               
                   
                   
                   
                 GCGUGAUCAACAAG 
                   
                   
               
               
                   
                   
                   
                 GACAUCAACGGCGU 
                   
                   
               
               
                   
                   
                   
                 GGUCCGCUGGGAUU 
                   
                   
               
               
                   
                   
                   
                 UCGCCCCACUGCAG 
                   
                   
               
               
                   
                   
                   
                 AGCCUGGAGCUGGA 
                   
                   
               
               
                   
                   
                   
                 GGCCGGCUACAGCA 
                   
                   
               
               
                   
                   
                   
                 GACAGGGGAACCUG 
                   
                   
               
               
                   
                   
                   
                 UACGCCGGCGAUAC 
                   
                   
               
               
                   
                   
                   
                 CCAGAACACCAACA 
                   
                   
               
               
                   
                   
                   
                 CCAACCAGCUGGUG 
                   
                   
               
               
                   
                   
                   
                 AAGGACAACUACGG 
                   
                   
               
               
                   
                   
                   
                 CAAGGAGACAAAUA 
                   
                   
               
               
                   
                   
                   
                 GACUGUACCGCCAG 
                   
                   
               
               
                   
                   
                   
                 AACUACAGCCUGAC 
                   
                   
               
               
                   
                   
                   
                 CUGGAACGGCGGCU 
                   
                   
               
               
                   
                   
                   
                 GGGACAACGGGGUG 
                   
                   
               
               
                   
                   
                   
                 ACCACCAGCAACUG 
                   
                   
               
               
                   
                   
                   
                 GGUGCAGUACGAGC 
                   
                   
               
               
                   
                   
                   
                 ACACCAGAAACAGC 
                   
                   
               
               
                   
                   
                   
                 AGAAUGCCCGAGGG 
                   
                   
               
               
                   
                   
                   
                 GCUGGCCGGUGGCA 
                   
                   
               
               
                   
                   
                   
                 CUGAAGGCAUCUUC 
                   
                   
               
               
                   
                   
                   
                 GACCCUAAAGCCAG 
                   
                   
               
               
                   
                   
                   
                 CCAGAAAUACGCUG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGAUCUGAAC 
                   
                   
               
               
                   
                   
                   
                 GACGUGACCCUGCA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAGGUGAGCC 
                   
                   
               
               
                   
                   
                   
                 UGCCUUUCGACCUG 
                   
                   
               
               
                   
                   
                   
                 CUCGUCAACCAGAA 
                   
                   
               
               
                   
                   
                   
                 CCUGACCCUGGGCA 
                   
                   
               
               
                   
                   
                   
                 CCGAGUGGGCCCAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGAAUGAAGGA 
                   
                   
               
               
                   
                   
                   
                 CCAGCUGAGCAACA 
                   
                   
               
               
                   
                   
                   
                 GCCAGACCUUCAUG 
                   
                   
               
               
                   
                   
                   
                 GGCGGAAACAUACC 
                   
                   
               
               
                   
                   
                   
                 AGGCUAUAGCAGCA 
                   
                   
               
               
                   
                   
                   
                 CCAACAGAAGCCCU 
                   
                   
               
               
                   
                   
                   
                 UACAGCAAGGCCGA 
                   
                   
               
               
                   
                   
                   
                 GAUCUUCUCCCUGU 
                   
                   
               
               
                   
                   
                   
                 UCGCCGAGAACAAC 
                   
                   
               
               
                   
                   
                   
                 AUGGAGCUGACCGA 
                   
                   
               
               
                   
                   
                   
                 CAGCACCAUGCUGA 
                   
                   
               
               
                   
                   
                   
                 CCCCUGGCAUCAGA 
                   
                   
               
               
                   
                   
                   
                 UUCGACCAUCACAG 
                   
                   
               
               
                   
                   
                   
                 CAUCGUGGGCGACA 
                   
                   
               
               
                   
                   
                   
                 ACUGGAGCCCCAGC 
                   
                   
               
               
                   
                   
                   
                 CUGAACCUGAGCCA 
                   
                   
               
               
                   
                   
                   
                 AGGCCUGGGCGACG 
                   
                   
               
               
                   
                   
                   
                 ACUUCACCCUGAAG 
                   
                   
               
               
                   
                   
                   
                 AUGGGCAUCGCCAG 
                   
                   
               
               
                   
                   
                   
                 AGCCUACAAGGCCC 
                   
                   
               
               
                   
                   
                   
                 CUAGCCUGUACCAG 
                   
                   
               
               
                   
                   
                   
                 ACCAACCCUAACUA 
                   
                   
               
               
                   
                   
                   
                 CAUCCUGUACAGCA 
                   
                   
               
               
                   
                   
                   
                 AGGGCCAGGGCUGU 
                   
                   
               
               
                   
                   
                   
                 UACGCAACCGGCGC 
                   
                   
               
               
                   
                   
                   
                 CGGCACAGGCAUCG 
                   
                   
               
               
                   
                   
                   
                 GCUGCUACAUGAUG 
                   
                   
               
               
                   
                   
                   
                 GGCAACGACGACCU 
                   
                   
               
               
                   
                   
                   
                 GAAGGCCGAAACUA 
                   
                   
               
               
                   
                   
                   
                 GCAUCAACAAGGAG 
                   
                   
               
               
                   
                   
                   
                 AUCGGCCUGGAGUU 
                   
                   
               
               
                   
                   
                   
                 CAAGAGGGACGGCU 
                   
                   
               
               
                   
                   
                   
                 GGCUCGCCGGAGUG 
                   
                   
               
               
                   
                   
                   
                 ACCUGGUUUAGAAA 
                   
                   
               
               
                   
                   
                   
                 CGACUACAGAAACA 
                   
                   
               
               
                   
                   
                   
                 AGAUCGAAGCCGGC 
                   
                   
               
               
                   
                   
                   
                 ACCGUACCUCUUCA 
                   
                   
               
               
                   
                   
                   
                 GCGGAUCAACAACG 
                   
                   
               
               
                   
                   
                   
                 GCAAGACCGACGUG 
                   
                   
               
               
                   
                   
                   
                 UACCAGUGGGAGAA 
                   
                   
               
               
                   
                   
                   
                 CGUGCCUAAGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGGUGGAGGGCCUC 
                   
                   
               
               
                   
                   
                   
                 GAGGGCACCCUCAA 
                   
                   
               
               
                   
                   
                   
                 CGUGCCUGUGAGCG 
                   
                   
               
               
                   
                   
                   
                 ACACCGUGAACUGG 
                   
                   
               
               
                   
                   
                   
                 ACCAACAACGUGAC 
                   
                   
               
               
                   
                   
                   
                 CUACAUGCUGCAGA 
                   
                   
               
               
                   
                   
                   
                 GCAAGAACAAGGAA 
                   
                   
               
               
                   
                   
                   
                 ACCGGCGAGAGACU 
                   
                   
               
               
                   
                   
                   
                 GAGCAUCAUCCCUC 
                   
                   
               
               
                   
                   
                   
                 AGUACACCCUGAAC 
                   
                   
               
               
                   
                   
                   
                 AGCACCCUGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GCAGGUGAGACAGG 
                   
                   
               
               
                   
                   
                   
                 ACGUGUCCCUGCAG 
                   
                   
               
               
                   
                   
                   
                 UCCACCUUUACGUG 
                   
                   
               
               
                   
                   
                   
                 GUACGGCAAGCAGG 
                   
                   
               
               
                   
                   
                   
                 AGCCUAAGAAGUAC 
                   
                   
               
               
                   
                   
                   
                 GACUACCAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 CCCUGUGACCGGCA 
                   
                   
               
               
                   
                   
                   
                 CCGACAAGCAGGCC 
                   
                   
               
               
                   
                   
                   
                 GUCAGCCCAUAUUC 
                   
                   
               
               
                   
                   
                   
                 CAUCGUGGGACUCA 
                   
                   
               
               
                   
                   
                   
                 GCGCCACCUGGGAC 
                   
                   
               
               
                   
                   
                   
                 GUGACCAAGAACGU 
                   
                   
               
               
                   
                   
                   
                 GAGCCUGACCGGAG 
                   
                   
               
               
                   
                   
                   
                 GGGUUGACAACCUG 
                   
                   
               
               
                   
                   
                   
                 UUCGACAAGAGACU 
                   
                   
               
               
                   
                   
                   
                 GUGGAGAGAGGGCA 
                   
                   
               
               
                   
                   
                   
                 ACGCCCAGACCGUG 
                   
                   
               
               
                   
                   
                   
                 AGGGACACUCAGAC 
                   
                   
               
               
                   
                   
                   
                 CGGCGCCUACAUGG 
                   
                   
               
               
                   
                   
                   
                 CCGGCGCUGGGGCC 
                   
                   
               
               
                   
                   
                   
                 UACACCUACAACGA 
                   
                   
               
               
                   
                   
                   
                 GCCCGGUCGGACCU 
                   
                   
               
               
                   
                   
                   
                 GGUACAUGUCCAUC 
                   
                   
               
               
                   
                   
                   
                 AACACCCACUUCCA 
                   
                   
               
               
                   
                   
                   
                 CCAUCACCAUCACC 
                   
                   
               
               
                   
                   
                   
                 AC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 91 
                 92 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 205 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 92, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_FepA_n 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACACCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 IgK 
                   PDTTG EEKTDSAALT 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 NEDTIVVTAAQQNLQ 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 APGVSTITADEIRKNP 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 PARDVSEIIRTMPGV 
                 CGGGGAGGAGAAGA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NLTGNSTSGQRGNNR 
                 CCGACAGCGCAGCC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 QIDIRGMGPENTLILI 
                 CUGACCAACGAGGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 DGKPVTSRNSVRLG 
                 CACCAUCGUGGUGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 WRGERDTRGDTAWV 
                 CCGCCGCUCAGCAG 
                   
                 UCCCCC 
               
               
                   
                   
                 PPEMIERIEVLRGPAA 
                 AACCUGCAGGCGCC 
                   
                 CAGCCC 
               
               
                   
                   
                 ARYGNGAAGGVVNII 
                 CGGCGUGAGCACCA 
                   
                 CUCCUC 
               
               
                   
                   
                 TKKGGSEWHGSWNT 
                 UCACCGCCGACGAG 
                   
                 CCCUUC 
               
               
                   
                   
                 YFNAPEHKDEGATK 
                 AUCAGAAAGAACCC 
                   
                 CUGCAC 
               
               
                   
                   
                 RTNFSLNGPLGGDFS 
                 UCCUGCCAGAGACG 
                   
                 CCGUAC 
               
               
                   
                   
                 FRLYGNLDKTQADA 
                 UGAGCGAGAUCAUC 
                   
                 CCCCGU 
               
               
                   
                   
                 RNINQGHQSERTGSY 
                 AGAACCAUGCCUGG 
                   
                 GGUCUU 
               
               
                   
                   
                 ADTLPAGREGVINKD 
                 CGUGAACCUGACCG 
                   
                 UGAAUA 
               
               
                   
                   
                 INGVVRWDFAPLQSL 
                 GCAACAGCACCAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 ELEAGYSRQGNLYA 
                 GGCCAGAGAGGCAA 
                   
                 GAGUGG 
               
               
                   
                   
                 GDTQNTNTNQLVKD 
                 CAACAGACAGAUCG 
                   
                 GCGGC 
               
               
                   
                   
                 NYGKETNRLYRQNY 
                 ACAUCAGAGGCAUG 
                   
                   
               
               
                   
                   
                 SLTWNGGWDNGVTT 
                 GGCCCUGAGAACAC 
                   
                   
               
               
                   
                   
                 SNWVQYEHTRNSRM 
                 CCUGAUCCUGAUCG 
                   
                   
               
               
                   
                   
                 PEGLAGGTEGIFDPK 
                 ACGGCAAGCCCGUG 
                   
                   
               
               
                   
                   
                 ASQKYADADLNDVT 
                 ACCAGCAGGAAUAG 
                   
                   
               
               
                   
                   
                 LHSEVSLPFDLLVNQ 
                 CGUGAGACUGGGCU 
                   
                   
               
               
                   
                   
                 NLTLGTEWAQQRMK 
                 GGAGAGGGGAGCGC 
                   
                   
               
               
                   
                   
                 DQLSNSQTFMGGNIP 
                 GACACAAGGGGCGA 
                   
                   
               
               
                   
                   
                 GYSSTNRSPYSKAEIF 
                 UACCGCCUGGGUGC 
                   
                   
               
               
                   
                   
                 SLFAENNMELTDSTM 
                 CUCCUGAGAUGAUC 
                   
                   
               
               
                   
                   
                 LTPGIRFDHHSIVGDN 
                 GAGAGAAUCGAGGU 
                   
                   
               
               
                   
                   
                 WSPSLNLSQGLGDDF 
                 GCUGAGAGGCCCUG 
                   
                   
               
               
                   
                   
                 TLKMGIARAYKAPSL 
                 CCGCCGCCAGAUAC 
                   
                   
               
               
                   
                   
                 YQTNPNYILYSKGQG 
                 GGGAACGGAGCCGC 
                   
                   
               
               
                   
                   
                 CYATGAGTGIGCYM 
                 CGGCGGCGUGGUGA 
                   
                   
               
               
                   
                   
                 MGNDDLKAETSINKE 
                 ACAUCAUCACCAAG 
                   
                   
               
               
                   
                   
                 IGLEFKRDGWLAGVT 
                 AAGGGCGGCAGCGA 
                   
                   
               
               
                   
                   
                 WFRNDYRNKIEAGT 
                 GUGGCACGGCAGCU 
                   
                   
               
               
                   
                   
                 VPLQRINNGKTDVYQ 
                 GGAACACCUACUUC 
                   
                   
               
               
                   
                   
                 WENVPKAVVEGLEG 
                 AACGCCCCUGAGCA 
                   
                   
               
               
                   
                   
                 TLNVPVSDTVNWTN 
                 CAAGGACGAGGGCG 
                   
                   
               
               
                   
                   
                 NVTYMLQSKNKETG 
                 CCACCAAGAGAACC 
                   
                   
               
               
                   
                   
                 ERLSIIPQYTLNSTLS 
                 AACUUCAGCCUGAA 
                   
                   
               
               
                   
                   
                 WQVRQDVSLQSTFT 
                 CGGCCCUCUGGGCG 
                   
                   
               
               
                   
                   
                 WYGKQEPKKYDYQG 
                 GCGACUUCAGCUUC 
                   
                   
               
               
                   
                   
                 NPVTGTDKQAVSPYS 
                 AGACUGUACGGCAA 
                   
                   
               
               
                   
                   
                 IVGLSATWDVTKNVS 
                 CCUGGACAAGACCC 
                   
                   
               
               
                   
                   
                 LTGGVDNLFDKRLW 
                 AGGCCGACGCCAGA 
                   
                   
               
               
                   
                   
                 REGNAQTVRDTQTG 
                 AACAUCAACCAGGG 
                   
                   
               
               
                   
                   
                 AYMAGAGAYTYNEP 
                 CCACCAGAGCGAGA 
                   
                   
               
               
                   
                   
                 GRTWYMSINTHF 
                 GAACCGGCAGCUAC 
                   
                   
               
               
                   
                   
                   
                 GCCGACACCCUGCC 
                   
                   
               
               
                   
                   
                   
                 UGCCGGCAGAGAGG 
                   
                   
               
               
                   
                   
                   
                 GCGUGAUCAACAAG 
                   
                   
               
               
                   
                   
                   
                 GACAUCAACGGCGU 
                   
                   
               
               
                   
                   
                   
                 GGUCCGCUGGGAUU 
                   
                   
               
               
                   
                   
                   
                 UCGCCCCACUGCAG 
                   
                   
               
               
                   
                   
                   
                 AGCCUGGAGCUGGA 
                   
                   
               
               
                   
                   
                   
                 GGCCGGCUACAGCA 
                   
                   
               
               
                   
                   
                   
                 GACAGGGGAACCUG 
                   
                   
               
               
                   
                   
                   
                 UACGCCGGCGAUAC 
                   
                   
               
               
                   
                   
                   
                 CCAGAACACCAACA 
                   
                   
               
               
                   
                   
                   
                 CCAACCAGCUGGUG 
                   
                   
               
               
                   
                   
                   
                 AAGGACAACUACGG 
                   
                   
               
               
                   
                   
                   
                 CAAGGAGACAAAUA 
                   
                   
               
               
                   
                   
                   
                 GACUGUACCGCCAG 
                   
                   
               
               
                   
                   
                   
                 AACUACAGCCUGAC 
                   
                   
               
               
                   
                   
                   
                 CUGGAACGGCGGCU 
                   
                   
               
               
                   
                   
                   
                 GGGACAACGGGGUG 
                   
                   
               
               
                   
                   
                   
                 ACCACCAGCAACUG 
                   
                   
               
               
                   
                   
                   
                 GGUGCAGUACGAGC 
                   
                   
               
               
                   
                   
                   
                 ACACCAGAAACAGC 
                   
                   
               
               
                   
                   
                   
                 AGAAUGCCCGAGGG 
                   
                   
               
               
                   
                   
                   
                 GCUGGCCGGUGGCA 
                   
                   
               
               
                   
                   
                   
                 CUGAAGGCAUCUUC 
                   
                   
               
               
                   
                   
                   
                 GACCCUAAAGCCAG 
                   
                   
               
               
                   
                   
                   
                 CCAGAAAUACGCUG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGAUCUGAAC 
                   
                   
               
               
                   
                   
                   
                 GACGUGACCCUGCA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAGGUGAGCC 
                   
                   
               
               
                   
                   
                   
                 UGCCUUUCGACCUG 
                   
                   
               
               
                   
                   
                   
                 CUCGUCAACCAGAA 
                   
                   
               
               
                   
                   
                   
                 CCUGACCCUGGGCA 
                   
                   
               
               
                   
                   
                   
                 CCGAGUGGGCCCAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGAAUGAAGGA 
                   
                   
               
               
                   
                   
                   
                 CCAGCUGAGCAACA 
                   
                   
               
               
                   
                   
                   
                 GCCAGACCUUCAUG 
                   
                   
               
               
                   
                   
                   
                 GGCGGAAACAUACC 
                   
                   
               
               
                   
                   
                   
                 AGGCUAUAGCAGCA 
                   
                   
               
               
                   
                   
                   
                 CCAACAGAAGCCCU 
                   
                   
               
               
                   
                   
                   
                 UACAGCAAGGCCGA 
                   
                   
               
               
                   
                   
                   
                 GAUCUUCUCCCUGU 
                   
                   
               
               
                   
                   
                   
                 UCGCCGAGAACAAC 
                   
                   
               
               
                   
                   
                   
                 AUGGAGCUGACCGA 
                   
                   
               
               
                   
                   
                   
                 CAGCACCAUGCUGA 
                   
                   
               
               
                   
                   
                   
                 CCCCUGGCAUCAGA 
                   
                   
               
               
                   
                   
                   
                 UUCGACCAUCACAG 
                   
                   
               
               
                   
                   
                   
                 CAUCGUGGGCGACA 
                   
                   
               
               
                   
                   
                   
                 ACUGGAGCCCCAGC 
                   
                   
               
               
                   
                   
                   
                 CUGAACCUGAGCCA 
                   
                   
               
               
                   
                   
                   
                 AGGCCUGGGCGACG 
                   
                   
               
               
                   
                   
                   
                 ACUUCACCCUGAAG 
                   
                   
               
               
                   
                   
                   
                 AUGGGCAUCGCCAG 
                   
                   
               
               
                   
                   
                   
                 AGCCUACAAGGCCC 
                   
                   
               
               
                   
                   
                   
                 CUAGCCUGUACCAG 
                   
                   
               
               
                   
                   
                   
                 ACCAACCCUAACUA 
                   
                   
               
               
                   
                   
                   
                 CAUCCUGUACAGCA 
                   
                   
               
               
                   
                   
                   
                 AGGGCCAGGGCUGU 
                   
                   
               
               
                   
                   
                   
                 UACGCAACCGGCGC 
                   
                   
               
               
                   
                   
                   
                 CGGCACAGGCAUCG 
                   
                   
               
               
                   
                   
                   
                 GCUGCUACAUGAUG 
                   
                   
               
               
                   
                   
                   
                 GGCAACGACGACCU 
                   
                   
               
               
                   
                   
                   
                 GAAGGCCGAAACUA 
                   
                   
               
               
                   
                   
                   
                 GCAUCAACAAGGAG 
                   
                   
               
               
                   
                   
                   
                 AUCGGCCUGGAGUU 
                   
                   
               
               
                   
                   
                   
                 CAAGAGGGACGGCU 
                   
                   
               
               
                   
                   
                   
                 GGCUCGCCGGAGUG 
                   
                   
               
               
                   
                   
                   
                 ACCUGGUUUAGAAA 
                   
                   
               
               
                   
                   
                   
                 CGACUACAGAAACA 
                   
                   
               
               
                   
                   
                   
                 AGAUCGAAGCCGGC 
                   
                   
               
               
                   
                   
                   
                 ACCGUACCUCUUCA 
                   
                   
               
               
                   
                   
                   
                 GCGGAUCAACAACG 
                   
                   
               
               
                   
                   
                   
                 GCAAGACCGACGUG 
                   
                   
               
               
                   
                   
                   
                 UACCAGUGGGAGAA 
                   
                   
               
               
                   
                   
                   
                 CGUGCCUAAGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGGUGGAGGGCCUC 
                   
                   
               
               
                   
                   
                   
                 GAGGGCACCCUCAA 
                   
                   
               
               
                   
                   
                   
                 CGUGCCUGUGAGCG 
                   
                   
               
               
                   
                   
                   
                 ACACCGUGAACUGG 
                   
                   
               
               
                   
                   
                   
                 ACCAACAACGUGAC 
                   
                   
               
               
                   
                   
                   
                 CUACAUGCUGCAGA 
                   
                   
               
               
                   
                   
                   
                 GCAAGAACAAGGAA 
                   
                   
               
               
                   
                   
                   
                 ACCGGCGAGAGACU 
                   
                   
               
               
                   
                   
                   
                 GAGCAUCAUCCCUC 
                   
                   
               
               
                   
                   
                   
                 AGUACACCCUGAAC 
                   
                   
               
               
                   
                   
                   
                 AGCACCCUGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GCAGGUGAGACAGG 
                   
                   
               
               
                   
                   
                   
                 ACGUGUCCCUGCAG 
                   
                   
               
               
                   
                   
                   
                 UCCACCUUUACGUG 
                   
                   
               
               
                   
                   
                   
                 GUACGGCAAGCAGG 
                   
                   
               
               
                   
                   
                   
                 AGCCUAAGAAGUAC 
                   
                   
               
               
                   
                   
                   
                 GACUACCAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 CCCUGUGACCGGCA 
                   
                   
               
               
                   
                   
                   
                 CCGACAAGCAGGCC 
                   
                   
               
               
                   
                   
                   
                 GUCAGCCCAUAUUC 
                   
                   
               
               
                   
                   
                   
                 CAUCGUGGGACUCA 
                   
                   
               
               
                   
                   
                   
                 GCGCCACCUGGGAC 
                   
                   
               
               
                   
                   
                   
                 GUGACCAAGAACGU 
                   
                   
               
               
                   
                   
                   
                 GAGCCUGACCGGAG 
                   
                   
               
               
                   
                   
                   
                 GGGUUGACAACCUG 
                   
                   
               
               
                   
                   
                   
                 UUCGACAAGAGACU 
                   
                   
               
               
                   
                   
                   
                 GUGGAGAGAGGGCA 
                   
                   
               
               
                   
                   
                   
                 ACGCCCAGACCGUG 
                   
                   
               
               
                   
                   
                   
                 AGGGACACUCAGAC 
                   
                   
               
               
                   
                   
                   
                 CGGCGCCUACAUGG 
                   
                   
               
               
                   
                   
                   
                 CCGGCGCUGGGGCC 
                   
                   
               
               
                   
                   
                   
                 UACACCUACAACGA 
                   
                   
               
               
                   
                   
                   
                 GCCCGGUCGGACCU 
                   
                   
               
               
                   
                   
                   
                 GGUACAUGUCCAUC 
                   
                   
               
               
                   
                   
                   
                 AACACCCACUUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 93 
                 94 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 206 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 94, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_FepA_ 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACACCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                   PDTTG EEKTDSAALT 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 K_cHis 
                 NEDTIVVTAAQQNLQ 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 APGVSTITADEIRKNP 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 PARDVSEIIRTMPGV 
                 CGGGGAGGAGAAGA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NLAGNSASGQRGNN 
                 CCGACAGCGCAGCC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 RQIDIRGMGPENTLIL 
                 CUGACCAACGAGGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 IDGKPVTSRNSVRLG 
                 CACCAUCGUGGUGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 WRGERDTRGDTAWV 
                 CCGCCGCUCAGCAG 
                   
                 UCCCCC 
               
               
                   
                   
                 PPEMIERIEVLRGPAA 
                 AACCUGCAGGCGCC 
                   
                 CAGCCC 
               
               
                   
                   
                 ARYGNGAAGGVVNII 
                 CGGCGUGAGCACCA 
                   
                 CUCCUC 
               
               
                   
                   
                 TKKGGSEWHGSWNT 
                 UCACCGCCGACGAG 
                   
                 CCCUUC 
               
               
                   
                   
                 YFNAPEHKDEGATK 
                 AUCAGAAAGAACCC 
                   
                 CUGCAC 
               
               
                   
                   
                 RTNFALNGPLGGDFS 
                 UCCUGCCAGAGACG 
                   
                 CCGUAC 
               
               
                   
                   
                 FRLYGNLDKTQADA 
                 UGAGCGAGAUCAUC 
                   
                 CCCCGU 
               
               
                   
                   
                 RNINQGHQSERTGSY 
                 AGAACCAUGCCUGG 
                   
                 GGUCUU 
               
               
                   
                   
                 ADTLPAGREGVINKD 
                 CGUGAACCUGGCCG 
                   
                 UGAAUA 
               
               
                   
                   
                 INGVVRWDFAPLQSL 
                 GCAACAGCGCCAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 ELEAGYSRQGNLYA 
                 GGCCAGAGAGGCAA 
                   
                 GAGUGG 
               
               
                   
                   
                 GDTQNTNTNQLVKD 
                 CAACAGACAGAUCG 
                   
                 GCGGC 
               
               
                   
                   
                 NYGKETNRLYRQNY 
                 ACAUCAGAGGCAUG 
                   
                   
               
               
                   
                   
                 ALTWNGGWDNGVT 
                 GGCCCUGAGAACAC 
                   
                   
               
               
                   
                   
                 TSNWVQYEHTRNSR 
                 CCUGAUCCUGAUCG 
                   
                   
               
               
                   
                   
                 MPEGLAGGTEGIFDP 
                 ACGGCAAGCCCGUG 
                   
                   
               
               
                   
                   
                 KASQKYADADLNDV 
                 ACCAGCAGGAAUAG 
                   
                   
               
               
                   
                   
                 TLHSEVSLPFDLLVN 
                 CGUGAGACUGGGCU 
                   
                   
               
               
                   
                   
                 QNLALGTEWAQQRM 
                 GGAGAGGGGAGCGC 
                   
                   
               
               
                   
                   
                 KDQLSNSQTFMGGNI 
                 GACACAAGGGGCGA 
                   
                   
               
               
                   
                   
                 PGYSSTNRSPYSKAEI 
                 UACCGCCUGGGUGC 
                   
                   
               
               
                   
                   
                 FSLFAENNMELTDST 
                 CUCCUGAGAUGAUC 
                   
                   
               
               
                   
                   
                 MLTPGIRFDHHSIVG 
                 GAGAGAAUCGAGGU 
                   
                   
               
               
                   
                   
                 DNWSPSLNLSQGLGD 
                 GCUGAGAGGCCCUG 
                   
                   
               
               
                   
                   
                 DFTLKMGIARAYKAP 
                 CCGCCGCCAGAUAC 
                   
                   
               
               
                   
                   
                 SLYQTNPNYILYSKG 
                 GGGAACGGAGCCGC 
                   
                   
               
               
                   
                   
                 QGCYATGAGTGIGC 
                 CGGCGGCGUGGUGA 
                   
                   
               
               
                   
                   
                 YMMGNDDLKAETSI 
                 ACAUCAUCACCAAG 
                   
                   
               
               
                   
                   
                 NKEIGLEFKRDGWLA 
                 AAGGGCGGCAGCGA 
                   
                   
               
               
                   
                   
                 GVTWFRNDYRNKIE 
                 GUGGCACGGCAGCU 
                   
                   
               
               
                   
                   
                 AGTVPLQRINNGKTD 
                 GGAACACCUACUUC 
                   
                   
               
               
                   
                   
                 VYQWENVPKAVVEG 
                 AACGCCCCUGAGCA 
                   
                   
               
               
                   
                   
                 LEGTLNVPVSDTVN 
                 CAAGGACGAGGGCG 
                   
                   
               
               
                   
                   
                 WANNVAYMLQSKN 
                 CCACCAAGAGAACC 
                   
                   
               
               
                   
                   
                 KETGERLSIIPQYTLN 
                 AACUUCGCACUGAA 
                   
                   
               
               
                   
                   
                 SALSWQVRQDVSLQ 
                 CGGCCCUCUGGGCG 
                   
                   
               
               
                   
                   
                 STFTWYGKQEPKKY 
                 GCGACUUCAGCUUC 
                   
                   
               
               
                   
                   
                 DYQGNPVTGTDKQA 
                 AGACUGUACGGCAA 
                   
                   
               
               
                   
                   
                 VSPYSIVGLSATWDV 
                 CCUGGACAAGACCC 
                   
                   
               
               
                   
                   
                 TKNVSLTGGVDNLFD 
                 AGGCCGACGCCAGA 
                   
                   
               
               
                   
                   
                 KRLWREGNAQTVRD 
                 AACAUCAACCAGGG 
                   
                   
               
               
                   
                   
                 TQTGAYMAGAGAYT 
                 CCACCAGAGCGAGA 
                   
                   
               
               
                   
                   
                 YNEPGRTWYMSINT 
                 GAACCGGCAGCUAC 
                   
                   
               
               
                   
                   
                 HFHHHHHH 
                 GCCGACACCCUGCC 
                   
                   
               
               
                   
                   
                   
                 UGCCGGCAGAGAGG 
                   
                   
               
               
                   
                   
                   
                 GCGUGAUCAACAAG 
                   
                   
               
               
                   
                   
                   
                 GACAUCAACGGCGU 
                   
                   
               
               
                   
                   
                   
                 GGUCCGCUGGGAUU 
                   
                   
               
               
                   
                   
                   
                 UCGCCCCACUGCAG 
                   
                   
               
               
                   
                   
                   
                 AGCCUGGAGCUGGA 
                   
                   
               
               
                   
                   
                   
                 GGCCGGCUACAGCA 
                   
                   
               
               
                   
                   
                   
                 GACAGGGGAACCUG 
                   
                   
               
               
                   
                   
                   
                 UACGCCGGCGAUAC 
                   
                   
               
               
                   
                   
                   
                 CCAGAACACCAACA 
                   
                   
               
               
                   
                   
                   
                 CCAACCAGCUGGUG 
                   
                   
               
               
                   
                   
                   
                 AAGGACAACUACGG 
                   
                   
               
               
                   
                   
                   
                 CAAGGAGACAAAUA 
                   
                   
               
               
                   
                   
                   
                 GACUGUACCGCCAG 
                   
                   
               
               
                   
                   
                   
                 AACUACGCACUGAC 
                   
                   
               
               
                   
                   
                   
                 CUGGAACGGCGGCU 
                   
                   
               
               
                   
                   
                   
                 GGGACAACGGGGUG 
                   
                   
               
               
                   
                   
                   
                 ACCACCAGCAACUG 
                   
                   
               
               
                   
                   
                   
                 GGUGCAGUACGAGC 
                   
                   
               
               
                   
                   
                   
                 ACACCAGAAACAGC 
                   
                   
               
               
                   
                   
                   
                 AGAAUGCCCGAGGG 
                   
                   
               
               
                   
                   
                   
                 GCUGGCCGGUGGCA 
                   
                   
               
               
                   
                   
                   
                 CUGAAGGCAUCUUC 
                   
                   
               
               
                   
                   
                   
                 GACCCUAAAGCCAG 
                   
                   
               
               
                   
                   
                   
                 CCAGAAAUACGCUG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGAUCUGAAC 
                   
                   
               
               
                   
                   
                   
                 GACGUGACCCUGCA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAGGUGAGCC 
                   
                   
               
               
                   
                   
                   
                 UGCCUUUCGACCUG 
                   
                   
               
               
                   
                   
                   
                 CUCGUCAACCAGAA 
                   
                   
               
               
                   
                   
                   
                 CCUGGCCCUGGGCA 
                   
                   
               
               
                   
                   
                   
                 CCGAGUGGGCCCAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGAAUGAAGGA 
                   
                   
               
               
                   
                   
                   
                 CCAGCUGAGCAACA 
                   
                   
               
               
                   
                   
                   
                 GCCAGACCUUCAUG 
                   
                   
               
               
                   
                   
                   
                 GGCGGAAACAUACC 
                   
                   
               
               
                   
                   
                   
                 AGGCUAUAGCAGCA 
                   
                   
               
               
                   
                   
                   
                 CCAACAGAAGCCCU 
                   
                   
               
               
                   
                   
                   
                 UACAGCAAGGCCGA 
                   
                   
               
               
                   
                   
                   
                 GAUCUUCUCCCUGU 
                   
                   
               
               
                   
                   
                   
                 UCGCCGAGAACAAC 
                   
                   
               
               
                   
                   
                   
                 AUGGAGCUGACCGA 
                   
                   
               
               
                   
                   
                   
                 CAGCACCAUGCUGA 
                   
                   
               
               
                   
                   
                   
                 CCCCUGGCAUCAGA 
                   
                   
               
               
                   
                   
                   
                 UUCGACCAUCACAG 
                   
                   
               
               
                   
                   
                   
                 CAUCGUGGGCGACA 
                   
                   
               
               
                   
                   
                   
                 ACUGGAGCCCCAGC 
                   
                   
               
               
                   
                   
                   
                 CUGAACCUGAGCCA 
                   
                   
               
               
                   
                   
                   
                 AGGCCUGGGCGACG 
                   
                   
               
               
                   
                   
                   
                 ACUUCACCCUGAAG 
                   
                   
               
               
                   
                   
                   
                 AUGGGCAUCGCCAG 
                   
                   
               
               
                   
                   
                   
                 AGCCUACAAGGCCC 
                   
                   
               
               
                   
                   
                   
                 CUAGCCUGUACCAG 
                   
                   
               
               
                   
                   
                   
                 ACCAACCCUAACUA 
                   
                   
               
               
                   
                   
                   
                 CAUCCUGUACAGCA 
                   
                   
               
               
                   
                   
                   
                 AGGGCCAGGGCUGU 
                   
                   
               
               
                   
                   
                   
                 UACGCAACCGGCGC 
                   
                   
               
               
                   
                   
                   
                 CGGCACAGGCAUCG 
                   
                   
               
               
                   
                   
                   
                 GCUGCUACAUGAUG 
                   
                   
               
               
                   
                   
                   
                 GGCAACGACGACCU 
                   
                   
               
               
                   
                   
                   
                 GAAGGCCGAAACUA 
                   
                   
               
               
                   
                   
                   
                 GCAUCAACAAGGAG 
                   
                   
               
               
                   
                   
                   
                 AUCGGCCUGGAGUU 
                   
                   
               
               
                   
                   
                   
                 CAAGAGGGACGGCU 
                   
                   
               
               
                   
                   
                   
                 GGCUCGCCGGAGUG 
                   
                   
               
               
                   
                   
                   
                 ACCUGGUUUAGAAA 
                   
                   
               
               
                   
                   
                   
                 CGACUACAGAAACA 
                   
                   
               
               
                   
                   
                   
                 AGAUCGAAGCCGGC 
                   
                   
               
               
                   
                   
                   
                 ACCGUACCUCUUCA 
                   
                   
               
               
                   
                   
                   
                 GCGGAUCAACAACG 
                   
                   
               
               
                   
                   
                   
                 GCAAGACCGACGUG 
                   
                   
               
               
                   
                   
                   
                 UACCAGUGGGAGAA 
                   
                   
               
               
                   
                   
                   
                 CGUGCCUAAGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGGUGGAGGGCCUC 
                   
                   
               
               
                   
                   
                   
                 GAGGGCACCCUCAA 
                   
                   
               
               
                   
                   
                   
                 CGUGCCUGUGAGCG 
                   
                   
               
               
                   
                   
                   
                 ACACCGUGAACUGG 
                   
                   
               
               
                   
                   
                   
                 GCCAACAACGUGGC 
                   
                   
               
               
                   
                   
                   
                 CUACAUGCUGCAGA 
                   
                   
               
               
                   
                   
                   
                 GCAAGAACAAGGAA 
                   
                   
               
               
                   
                   
                   
                 GAGCAUCAUCCCUC 
                   
                   
               
               
                   
                   
                   
                 AGUACACCCUGAAC 
                   
                   
               
               
                   
                   
                   
                 AGCGCCCUGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GCAGGUGAGACAGG 
                   
                   
               
               
                   
                   
                   
                 ACGUGUCCCUGCAG 
                   
                   
               
               
                   
                   
                   
                 UCCACCUUUACGUG 
                   
                   
               
               
                   
                   
                   
                 GUACGGCAAGCAGG 
                   
                   
               
               
                   
                   
                   
                 AGCCUAAGAAGUAC 
                   
                   
               
               
                   
                   
                   
                 GACUACCAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 CCCUGUGACCGGCA 
                   
                   
               
               
                   
                   
                   
                 CCGACAAGCAGGCC 
                   
                   
               
               
                   
                   
                   
                 GUCAGCCCAUAUUC 
                   
                   
               
               
                   
                   
                   
                 CAUCGUGGGACUCA 
                   
                   
               
               
                   
                   
                   
                 GCGCCACCUGGGAC 
                   
                   
               
               
                   
                   
                   
                 GUGACCAAGAACGU 
                   
                   
               
               
                   
                   
                   
                 GAGCCUGACCGGAG 
                   
                   
               
               
                   
                   
                   
                 GGGUUGACAACCUG 
                   
                   
               
               
                   
                   
                   
                 UUCGACAAGAGACU 
                   
                   
               
               
                   
                   
                   
                 GUGGAGAGAGGGCA 
                   
                   
               
               
                   
                   
                   
                 ACGCCCAGACCGUG 
                   
                   
               
               
                   
                   
                   
                 AGGGACACUCAGAC 
                   
                   
               
               
                   
                   
                   
                 CGGCGCCUACAUGG 
                   
                   
               
               
                   
                   
                   
                 CCGGCGCUGGGGCC 
                   
                   
               
               
                   
                   
                   
                 UACACCUACAACGA 
                   
                   
               
               
                   
                   
                   
                 GCCCGGUCGGACCU 
                   
                   
               
               
                   
                   
                   
                 GGUACAUGUCCAUC 
                   
                   
               
               
                   
                   
                   
                 AACACCCACUUCCA 
                   
                   
               
               
                   
                   
                   
                 CCAUCACCAUCACC 
                   
                   
               
               
                   
                   
                   
                 AC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 95 
                 96 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 207 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 96, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_FepA_ 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACACCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                   PDTTG EEKTDSAALT 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 K 
                 NEDTIVVTAAQQNLQ 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 APGVSTITADEIRKNP 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 PARDVSEIIRTMPGV 
                 CGGGGAGGAGAAGA 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NLAGNSASGQRGNN 
                 CCGACAGCGCAGCC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 RQIDIRGMGPENTLIL 
                 CUGACCAACGAGGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 IDGKPVTSRNSVRLG 
                 CACCAUCGUGGUGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 WRGERDTRGDTAWV 
                 CCGCCGCUCAGCAG 
                   
                 UCCCCC 
               
               
                   
                   
                 PPEMIERIEVLRGPAA 
                 AACCUGCAGGCGCC 
                   
                 CAGCCC 
               
               
                   
                   
                 ARYGNGAAGGVVNII 
                 CGGCGUGAGCACCA 
                   
                 CUCCUC 
               
               
                   
                   
                 TKKGGSEWHGSWNT 
                 UCACCGCCGACGAG 
                   
                 CCCUUC 
               
               
                   
                   
                 YFNAPEHKDEGATK 
                 AUCAGAAAGAACCC 
                   
                 CUGCAC 
               
               
                   
                   
                 RTNFALNGPLGGDFS 
                 UCCUGCCAGAGACG 
                   
                 CCGUAC 
               
               
                   
                   
                 FRLYGNLDKTQADA 
                 UGAGCGAGAUCAUC 
                   
                 CCCCGU 
               
               
                   
                   
                 RNINQGHQSERTGSY 
                 AGAACCAUGCCUGG 
                   
                 GGUCUU 
               
               
                   
                   
                 ADTLPAGREGVINKD 
                 CGUGAACCUGGCCG 
                   
                 UGAAUA 
               
               
                   
                   
                 INGVVRWDFAPLQSL 
                 GCAACAGCGCCAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 ELEAGYSRQGNLYA 
                 GGCCAGAGAGGCAA 
                   
                 GAGUGG 
               
               
                   
                   
                 GDTQNTNTNQLVKD 
                 CAACAGACAGAUCG 
                   
                 GCGGC 
               
               
                   
                   
                 NYGKETNRLYRQNY 
                 ACAUCAGAGGCAUG 
                   
                   
               
               
                   
                   
                 ALTWNGGWDNGVT 
                 GGCCCUGAGAACAC 
                   
                   
               
               
                   
                   
                 TSNWVQYEHTRNSR 
                 CCUGAUCCUGAUCG 
                   
                   
               
               
                   
                   
                 MPEGLAGGTEGIFDP 
                 ACGGCAAGCCCGUG 
                   
                   
               
               
                   
                   
                 KASQKYADADLNDV 
                 ACCAGCAGGAAUAG 
                   
                   
               
               
                   
                   
                 TLHSEVSLPFDLLVN 
                 CGUGAGACUGGGCU 
                   
                   
               
               
                   
                   
                 QNLALGTEWAQQRM 
                 GGAGAGGGGAGCGC 
                   
                   
               
               
                   
                   
                 KDQLSNSQTFMGGNI 
                 GACACAAGGGGCGA 
                   
                   
               
               
                   
                   
                 PGYSSTNRSPYSKAEI 
                 UACCGCCUGGGUGC 
                   
                   
               
               
                   
                   
                 FSLFAENNMELTDST 
                 CUCCUGAGAUGAUC 
                   
                   
               
               
                   
                   
                 MLTPGIRFDHHSIVG 
                 GAGAGAAUCGAGGU 
                   
                   
               
               
                   
                   
                 DNWSPSLNLSQGLGD 
                 GCUGAGAGGCCCUG 
                   
                   
               
               
                   
                   
                 DFTLKMGIARAYKAP 
                 CCGCCGCCAGAUAC 
                   
                   
               
               
                   
                   
                 SLYQTNPNYILYSKG 
                 GGGAACGGAGCCGC 
                   
                   
               
               
                   
                   
                 QGCYATGAGTGIGC 
                 CGGCGGCGUGGUGA 
                   
                   
               
               
                   
                   
                 YMMGNDDLKAETSI 
                 ACAUCAUCACCAAG 
                   
                   
               
               
                   
                   
                 NKEIGLEFKRDGWLA 
                 AAGGGCGGCAGCGA 
                   
                   
               
               
                   
                   
                 GVTWFRNDYRNKIE 
                 GUGGCACGGCAGCU 
                   
                   
               
               
                   
                   
                 AGTVPLQRINNGKTD 
                 GGAACACCUACUUC 
                   
                   
               
               
                   
                   
                 VYQWENVPKAVVEG 
                 AACGCCCCUGAGCA 
                   
                   
               
               
                   
                   
                 LEGTLNVPVSDTVN 
                 CAAGGACGAGGGCG 
                   
                   
               
               
                   
                   
                 WANNVAYMLQSKN 
                 CCACCAAGAGAACC 
                   
                   
               
               
                   
                   
                 KETGERLSIIPQYTLN 
                 AACUUCGCACUGAA 
                   
                   
               
               
                   
                   
                 SALSWQVRQDVSLQ 
                 CGGCCCUCUGGGCG 
                   
                   
               
               
                   
                   
                 STFTWYGKQEPKKY 
                 GCGACUUCAGCUUC 
                   
                   
               
               
                   
                   
                 DYQGNPVTGTDKQA 
                 AGACUGUACGGCAA 
                   
                   
               
               
                   
                   
                 VSPYSIVGLSATWDV 
                 CCUGGACAAGACCC 
                   
                   
               
               
                   
                   
                 TKNVSLTGGVDNLFD 
                 AGGCCGACGCCAGA 
                   
                   
               
               
                   
                   
                 KRLWREGNAQTVRD 
                 AACAUCAACCAGGG 
                   
                   
               
               
                   
                   
                 TQTGAYMAGAGAYT 
                 CCACCAGAGCGAGA 
                   
                   
               
               
                   
                   
                 YNEPGRTWYMSINT 
                 GAACCGGCAGCUAC 
                   
                   
               
               
                   
                   
                 HF 
                 GCCGACACCCUGCC 
                   
                   
               
               
                   
                   
                   
                 UGCCGGCAGAGAGG 
                   
                   
               
               
                   
                   
                   
                 GCGUGAUCAACAAG 
                   
                   
               
               
                   
                   
                   
                 GACAUCAACGGCGU 
                   
                   
               
               
                   
                   
                   
                 GGUCCGCUGGGAUU 
                   
                   
               
               
                   
                   
                   
                 UCGCCCCACUGCAG 
                   
                   
               
               
                   
                   
                   
                 AGCCUGGAGCUGGA 
                   
                   
               
               
                   
                   
                   
                 GGCCGGCUACAGCA 
                   
                   
               
               
                   
                   
                   
                 GACAGGGGAACCUG 
                   
                   
               
               
                   
                   
                   
                 UACGCCGGCGAUAC 
                   
                   
               
               
                   
                   
                   
                 CCAGAACACCAACA 
                   
                   
               
               
                   
                   
                   
                 CCAACCAGCUGGUG 
                   
                   
               
               
                   
                   
                   
                 AAGGACAACUACGG 
                   
                   
               
               
                   
                   
                   
                 CAAGGAGACAAAUA 
                   
                   
               
               
                   
                   
                   
                 GACUGUACCGCCAG 
                   
                   
               
               
                   
                   
                   
                 AACUACGCACUGAC 
                   
                   
               
               
                   
                   
                   
                 CUGGAACGGCGGCU 
                   
                   
               
               
                   
                   
                   
                 GGGACAACGGGGUG 
                   
                   
               
               
                   
                   
                   
                 ACCACCAGCAACUG 
                   
                   
               
               
                   
                   
                   
                 GGUGCAGUACGAGC 
                   
                   
               
               
                   
                   
                   
                 ACACCAGAAACAGC 
                   
                   
               
               
                   
                   
                   
                 AGAAUGCCCGAGGG 
                   
                   
               
               
                   
                   
                   
                 GCUGGCCGGUGGCA 
                   
                   
               
               
                   
                   
                   
                 CUGAAGGCAUCUUC 
                   
                   
               
               
                   
                   
                   
                 GACCCUAAAGCCAG 
                   
                   
               
               
                   
                   
                   
                 CCAGAAAUACGCUG 
                   
                   
               
               
                   
                   
                   
                 ACGCCGAUCUGAAC 
                   
                   
               
               
                   
                   
                   
                 GACGUGACCCUGCA 
                   
                   
               
               
                   
                   
                   
                 CAGCGAGGUGAGCC 
                   
                   
               
               
                   
                   
                   
                 UGCCUUUCGACCUG 
                   
                   
               
               
                   
                   
                   
                 CUCGUCAACCAGAA 
                   
                   
               
               
                   
                   
                   
                 CCUGGCCCUGGGCA 
                   
                   
               
               
                   
                   
                   
                 CCGAGUGGGCCCAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGAAUGAAGGA 
                   
                   
               
               
                   
                   
                   
                 CCAGCUGAGCAACA 
                   
                   
               
               
                   
                   
                   
                 GCCAGACCUUCAUG 
                   
                   
               
               
                   
                   
                   
                 GGCGGAAACAUACC 
                   
                   
               
               
                   
                   
                   
                 AGGCUAUAGCAGCA 
                   
                   
               
               
                   
                   
                   
                 CCAACAGAAGCCCU 
                   
                   
               
               
                   
                   
                   
                 UACAGCAAGGCCGA 
                   
                   
               
               
                   
                   
                   
                 GAUCUUCUCCCUGU 
                   
                   
               
               
                   
                   
                   
                 UCGCCGAGAACAAC 
                   
                   
               
               
                   
                   
                   
                 AUGGAGCUGACCGA 
                   
                   
               
               
                   
                   
                   
                 CAGCACCAUGCUGA 
                   
                   
               
               
                   
                   
                   
                 CCCCUGGCAUCAGA 
                   
                   
               
               
                   
                   
                   
                 UUCGACCAUCACAG 
                   
                   
               
               
                   
                   
                   
                 CAUCGUGGGCGACA 
                   
                   
               
               
                   
                   
                   
                 ACUGGAGCCCCAGC 
                   
                   
               
               
                   
                   
                   
                 CUGAACCUGAGCCA 
                   
                   
               
               
                   
                   
                   
                 AGGCCUGGGCGACG 
                   
                   
               
               
                   
                   
                   
                 ACUUCACCCUGAAG 
                   
                   
               
               
                   
                   
                   
                 AUGGGCAUCGCCAG 
                   
                   
               
               
                   
                   
                   
                 AGCCUACAAGGCCC 
                   
                   
               
               
                   
                   
                   
                 CUAGCCUGUACCAG 
                   
                   
               
               
                   
                   
                   
                 ACCAACCCUAACUA 
                   
                   
               
               
                   
                   
                   
                 CAUCCUGUACAGCA 
                   
                   
               
               
                   
                   
                   
                 AGGGCCAGGGCUGU 
                   
                   
               
               
                   
                   
                   
                 UACGCAACCGGCGC 
                   
                   
               
               
                   
                   
                   
                 CGGCACAGGCAUCG 
                   
                   
               
               
                   
                   
                   
                 GCUGCUACAUGAUG 
                   
                   
               
               
                   
                   
                   
                 GGCAACGACGACCU 
                   
                   
               
               
                   
                   
                   
                 GAAGGCCGAAACUA 
                   
                   
               
               
                   
                   
                   
                 GCAUCAACAAGGAG 
                   
                   
               
               
                   
                   
                   
                 AUCGGCCUGGAGUU 
                   
                   
               
               
                   
                   
                   
                 CAAGAGGGACGGCU 
                   
                   
               
               
                   
                   
                   
                 GGCUCGCCGGAGUG 
                   
                   
               
               
                   
                   
                   
                 ACCUGGUUUAGAAA 
                   
                   
               
               
                   
                   
                   
                 CGACUACAGAAACA 
                   
                   
               
               
                   
                   
                   
                 AGAUCGAAGCCGGC 
                   
                   
               
               
                   
                   
                   
                 ACCGUACCUCUUCA 
                   
                   
               
               
                   
                   
                   
                 GCGGAUCAACAACG 
                   
                   
               
               
                   
                   
                   
                 GCAAGACCGACGUG 
                   
                   
               
               
                   
                   
                   
                 UACCAGUGGGAGAA 
                   
                   
               
               
                   
                   
                   
                 CGUGCCUAAGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGGUGGAGGGCCUC 
                   
                   
               
               
                   
                   
                   
                 GAGGGCACCCUCAA 
                   
                   
               
               
                   
                   
                   
                 CGUGCCUGUGAGCG 
                   
                   
               
               
                   
                   
                   
                 ACACCGUGAACUGG 
                   
                   
               
               
                   
                   
                   
                 GCCAACAACGUGGC 
                   
                   
               
               
                   
                   
                   
                 CUACAUGCUGCAGA 
                   
                   
               
               
                   
                   
                   
                 GCAAGAACAAGGAA 
                   
                   
               
               
                   
                   
                   
                 ACCGGCGAGAGACU 
                   
                   
               
               
                   
                   
                   
                 GAGCAUCAUCCCUC 
                   
                   
               
               
                   
                   
                   
                 AGUACACCCUGAAC 
                   
                   
               
               
                   
                   
                   
                 AGCGCCCUGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GCAGGUGAGACAGG 
                   
                   
               
               
                   
                   
                   
                 ACGUGUCCCUGCAG 
                   
                   
               
               
                   
                   
                   
                 UCCACCUUUACGUG 
                   
                   
               
               
                   
                   
                   
                 GUACGGCAAGCAGG 
                   
                   
               
               
                   
                   
                   
                 AGCCUAAGAAGUAC 
                   
                   
               
               
                   
                   
                   
                 GACUACCAGGGCAA 
                   
                   
               
               
                   
                   
                   
                 CCCUGUGACCGGCA 
                   
                   
               
               
                   
                   
                   
                 GUCAGCCCAUAUUC 
                   
                   
               
               
                   
                   
                   
                 CAUCGUGGGACUCA 
                   
                   
               
               
                   
                   
                   
                 GCGCCACCUGGGAC 
                   
                   
               
               
                   
                   
                   
                 GUGACCAAGAACGU 
                   
                   
               
               
                   
                   
                   
                 GAGCCUGACCGGAG 
                   
                   
               
               
                   
                   
                   
                 GGGUUGACAACCUG 
                   
                   
               
               
                   
                   
                   
                 UUCGACAAGAGACU 
                   
                   
               
               
                   
                   
                   
                 GUGGAGAGAGGGCA 
                   
                   
               
               
                   
                   
                   
                 ACGCCCAGACCGUG 
                   
                   
               
               
                   
                   
                   
                 AGGGACACUCAGAC 
                   
                   
               
               
                   
                   
                   
                 CGGCGCCUACAUGG 
                   
                   
               
               
                   
                   
                   
                 CCGGCGCUGGGGCC 
                   
                   
               
               
                   
                   
                   
                 UACACCUACAACGA 
                   
                   
               
               
                   
                   
                   
                 GCCCGGUCGGACCU 
                   
                   
               
               
                   
                   
                   
                 GGUACAUGUCCAUC 
                   
                   
               
               
                   
                   
                   
                 AACACCCACUUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 97 
                 98 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 208 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 98, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_CdtB_n 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACUCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 IgK 
                   PDTTG NISDYKVMT 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 WNLQGSSASTESKW 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 NVNVRQLLSGTAGV 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 DILMVQEAGAVPTSA 
                 CGGCAACAUCAGCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 VPTGRHIQPFGVGIPI 
                 ACUACAAGGUGAUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 DEYTWNLGTTSRQDI 
                 ACCUGGAACCUGCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 RYIYHSAIDVGARRV 
                 GGGAAGCUCCGCCA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 NLAIVSRQRADNVYV 
                 GCACCGAGAGCAAG 
                   
                 UCCCCC 
               
               
                   
                   
                 LRPTTVASRPVIGIGL 
                 UGGAACGUGAACGU 
                   
                 CAGCCC 
               
               
                   
                   
                 GNDVFLTAHALASG 
                 GAGACAGCUCCUGA 
                   
                 CUCCUC 
               
               
                   
                   
                 GPDAAAIVRVTINFFR 
                 GCGGCACCGCCGGC 
                   
                 CCCUUC 
               
               
                   
                   
                 QPQMRHLSWFLAGD 
                 GUCGACAUCCUGAU 
                   
                 CUGCAC 
               
               
                   
                   
                 FNRSPDRLENDLMTE 
                 GGUGCAGGAGGCCG 
                   
                 CCGUAC 
               
               
                   
                   
                 HLERVVAVLAPTEPT 
                 GAGCCGUCCCUACC 
                   
                 CCCCGU 
               
               
                   
                   
                 QIGGGILDYGVIVDR 
                 AGCGCCGUGCCUAC 
                   
                 GGUCUU 
               
               
                   
                   
                 APYSQRVEALRNPQL 
                 CGGCAGACACAUCC 
                   
                 UGAAUA 
               
               
                   
                   
                 ASDHYPVAFLARSC 
                 AGCCUUUCGGCGUG 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 GGCAUCCCUAUCGA 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CGAGUACACCUGGA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 AUCUCGGCACCACC 
                   
                   
               
               
                   
                   
                   
                 AGCAGACAGGACAU 
                   
                   
               
               
                   
                   
                   
                 CAGAUACAUCUACC 
                   
                   
               
               
                   
                   
                   
                 ACAGCGCCAUCGAC 
                   
                   
               
               
                   
                   
                   
                 GUGGGCGCCAGAAG 
                   
                   
               
               
                   
                   
                   
                 AGUGAACCUGGCCA 
                   
                   
               
               
                   
                   
                   
                 UCGUGAGCAGACAG 
                   
                   
               
               
                   
                   
                   
                 AGAGCCGACAACGU 
                   
                   
               
               
                   
                   
                   
                 GUACGUGCUGAGGC 
                   
                   
               
               
                   
                   
                   
                 CUACCACCGUGGCC 
                   
                   
               
               
                   
                   
                   
                 AGCAGACCUGUGAU 
                   
                   
               
               
                   
                   
                   
                 CGGCAUCGGCCUGG 
                   
                   
               
               
                   
                   
                   
                 GCAACGACGUGUUC 
                   
                   
               
               
                   
                   
                   
                 CUGACCGCCCACGC 
                   
                   
               
               
                   
                   
                   
                 UCUGGCCUCCGGUG 
                   
                   
               
               
                   
                   
                   
                 GCCCCGACGCUGCC 
                   
                   
               
               
                   
                   
                   
                 GCCAUCGUGAGAGU 
                   
                   
               
               
                   
                   
                   
                 GACCAUCAACUUCU 
                   
                   
               
               
                   
                   
                   
                 UCAGACAGCCUCAG 
                   
                   
               
               
                   
                   
                   
                 AUGAGACACCUGAG 
                   
                   
               
               
                   
                   
                   
                 CUGGUUCCUGGCCG 
                   
                   
               
               
                   
                   
                   
                 GCGACUUCAACAGA 
                   
                   
               
               
                   
                   
                   
                 AGCCCUGACAGACU 
                   
                   
               
               
                   
                   
                   
                 GGAGAACGACCUGA 
                   
                   
               
               
                   
                   
                   
                 UGACCGAGCACCUG 
                   
                   
               
               
                   
                   
                   
                 GAGAGAGUGGUGGC 
                   
                   
               
               
                   
                   
                   
                 CGUGCUGGCCCCUA 
                   
                   
               
               
                   
                   
                   
                 CCGAGCCUACCCAG 
                   
                   
               
               
                   
                   
                   
                 AUCGGCGGCGGCAU 
                   
                   
               
               
                   
                   
                   
                 CCUGGACUACGGCG 
                   
                   
               
               
                   
                   
                   
                 UGAUCGUGGACAGA 
                   
                   
               
               
                   
                   
                   
                 GCCCCUUACAGCCA 
                   
                   
               
               
                   
                   
                   
                 GAGAGUGGAGGCCC 
                   
                   
               
               
                   
                   
                   
                 UGAGAAACCCUCAG 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAGCGACCA 
                   
                   
               
               
                   
                   
                   
                 CUACCCUGUGGCCU 
                   
                   
               
               
                   
                   
                   
                 UCCUGGCCAGAAGC 
                   
                   
               
               
                   
                   
                   
                 UGC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 157 
                 158 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 209 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 158, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_CdtB_n 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACUCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 IgK_cHis 
                   PDTTG NISDYKVMT 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 WNLQGSSASTESKW 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 NVNVRQLLSGTAGV 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 DILMVQEAGAVPTSA 
                 CGGCAACAUCAGCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 VPTGRHIQPFGVGIPI 
                 ACUACAAGGUGAUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 DEYTWNLGTTSRQDI 
                 ACCUGGAACCUGCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 RYIYHSAIDVGARRV 
                 GGGAAGCUCCGCCA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 NLAIVSRQRADNVYV 
                 GCACCGAGAGCAAG 
                   
                 UCCCCC 
               
               
                   
                   
                 LRPTTVASRPVIGIGL 
                 UGGAACGUGAACGU 
                   
                 CAGCCC 
               
               
                   
                   
                 GNDVFLTAHALASG 
                 GAGACAGCUCCUGA 
                   
                 CUCCUC 
               
               
                   
                   
                 GPDAAAIVRVTINFFR 
                 GCGGCACCGCCGGC 
                   
                 CCCUUC 
               
               
                   
                   
                 QPQMRHLSWFLAGD 
                 GUCGACAUCCUGAU 
                   
                 CUGCAC 
               
               
                   
                   
                 FNRSPDRLENDLMTE 
                 GGUGCAGGAGGCCG 
                   
                 CCGUAC 
               
               
                   
                   
                 HLERVVAVLAPTEPT 
                 GAGCCGUCCCUACC 
                   
                 CCCCGU 
               
               
                   
                   
                 QIGGGILDYGVIVDR 
                 AGCGCCGUGCCUAC 
                   
                 GGUCUU 
               
               
                   
                   
                 APYSQRVEALRNPQL 
                 CGGCAGACACAUCC 
                   
                 UGAAUA 
               
               
                   
                   
                 ASDHYPVAFLARSCH 
                 AGCCUUUCGGCGUG 
                   
                 AAGUCU 
               
               
                   
                   
                 HHHHH 
                 GGCAUCCCUAUCGA 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CGAGUACACCUGGA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 AUCUCGGCACCACC 
                   
                   
               
               
                   
                   
                   
                 AGCAGACAGGACAU 
                   
                   
               
               
                   
                   
                   
                 CAGAUACAUCUACC 
                   
                   
               
               
                   
                   
                   
                 ACAGCGCCAUCGAC 
                   
                   
               
               
                   
                   
                   
                 GUGGGCGCCAGAAG 
                   
                   
               
               
                   
                   
                   
                 AGUGAACCUGGCCA 
                   
                   
               
               
                   
                   
                   
                 UCGUGAGCAGACAG 
                   
                   
               
               
                   
                   
                   
                 AGAGCCGACAACGU 
                   
                   
               
               
                   
                   
                   
                 GUACGUGCUGAGGC 
                   
                   
               
               
                   
                   
                   
                 CUACCACCGUGGCC 
                   
                   
               
               
                   
                   
                   
                 AGCAGACCUGUGAU 
                   
                   
               
               
                   
                   
                   
                 CGGCAUCGGCCUGG 
                   
                   
               
               
                   
                   
                   
                 GCAACGACGUGUUC 
                   
                   
               
               
                   
                   
                   
                 CUGACCGCCCACGC 
                   
                   
               
               
                   
                   
                   
                 UCUGGCCUCCGGUG 
                   
                   
               
               
                   
                   
                   
                 GCCCCGACGCUGCC 
                   
                   
               
               
                   
                   
                   
                 GCCAUCGUGAGAGU 
                   
                   
               
               
                   
                   
                   
                 GACCAUCAACUUCU 
                   
                   
               
               
                   
                   
                   
                 UCAGACAGCCUCAG 
                   
                   
               
               
                   
                   
                   
                 AUGAGACACCUGAG 
                   
                   
               
               
                   
                   
                   
                 CUGGUUCCUGGCCG 
                   
                   
               
               
                   
                   
                   
                 GCGACUUCAACAGA 
                   
                   
               
               
                   
                   
                   
                 AGCCCUGACAGACU 
                   
                   
               
               
                   
                   
                   
                 GGAGAACGACCUGA 
                   
                   
               
               
                   
                   
                   
                 UGACCGAGCACCUG 
                   
                   
               
               
                   
                   
                   
                 GAGAGAGUGGUGGC 
                   
                   
               
               
                   
                   
                   
                 CGUGCUGGCCCCUA 
                   
                   
               
               
                   
                   
                   
                 CCGAGCCUACCCAG 
                   
                   
               
               
                   
                   
                   
                 AUCGGCGGCGGCAU 
                   
                   
               
               
                   
                   
                   
                 CCUGGACUACGGCG 
                   
                   
               
               
                   
                   
                   
                 UGAUCGUGGACAGA 
                   
                   
               
               
                   
                   
                   
                 GCCCCUUACAGCCA 
                   
                   
               
               
                   
                   
                   
                 GAGAGUGGAGGCCC 
                   
                   
               
               
                   
                   
                   
                 UGAGAAACCCUCAG 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAGCGACCA 
                   
                   
               
               
                   
                   
                   
                 CUACCCUGUGGCCU 
                   
                   
               
               
                   
                   
                   
                 UCCUGGCCAGAAGC 
                   
                   
               
               
                   
                   
                   
                 UGCCAUCACCACCA 
                   
                   
               
               
                   
                   
                   
                 CCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 99 
                 100 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 210 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 100, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_CdtB_ 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACUCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                   PDTTG NIADYKVMT 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 K 
                 WNLQGSSASTESKW 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 NVNVRQLLSGTAGV 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 DILMVQEAGAVPTSA 
                 CGGCAACAUCGCAG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 VPTGRHIQPFGVGIPI 
                 ACUACAAGGUGAUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 DEYTWNLGTTSRQDI 
                 ACCUGGAACCUGCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 RYIYHSAIDVGARRV 
                 GGGAAGCUCCGCCA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 NLAIVSRQRADNVYV 
                 GCACCGAGAGCAAG 
                   
                 UCCCCC 
               
               
                   
                   
                 LRPTTVASRPVIGIGL 
                 UGGAACGUGAACGU 
                   
                 CAGCCC 
               
               
                   
                   
                 GNDVFLTAHALASG 
                 GAGACAGCUCCUGA 
                   
                 CUCCUC 
               
               
                   
                   
                 GPDAAAIVRVTINFFR 
                 GCGGCACCGCCGGC 
                   
                 CCCUUC 
               
               
                   
                   
                 QPQMRHLSWFLAGD 
                 GUCGACAUCCUGAU 
                   
                 CUGCAC 
               
               
                   
                   
                 FNRSPDRLENDLMTE 
                 GGUGCAGGAGGCCG 
                   
                 CCGUAC 
               
               
                   
                   
                 HLERVVAVLAPTEPT 
                 GAGCCGUCCCUACC 
                   
                 CCCCGU 
               
               
                   
                   
                 QIGGGILDYGVIVDR 
                 AGCGCCGUGCCUAC 
                   
                 GGUCUU 
               
               
                   
                   
                 APYSQRVEALRNPQL 
                 CGGCAGACACAUCC 
                   
                 UGAAUA 
               
               
                   
                   
                 ASDHYPVAFLARSC 
                 AGCCUUUCGGCGUG 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 GGCAUCCCUAUCGA 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CGAGUACACCUGGA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 AUCUCGGCACCACC 
                   
                   
               
               
                   
                   
                   
                 AGCAGACAGGACAU 
                   
                   
               
               
                   
                   
                   
                 CAGAUACAUCUACC 
                   
                   
               
               
                   
                   
                   
                 ACAGCGCCAUCGAC 
                   
                   
               
               
                   
                   
                   
                 GUGGGCGCCAGAAG 
                   
                   
               
               
                   
                   
                   
                 AGUGAACCUGGCCA 
                   
                   
               
               
                   
                   
                   
                 UCGUGAGCAGACAG 
                   
                   
               
               
                   
                   
                   
                 AGAGCCGACAACGU 
                   
                   
               
               
                   
                   
                   
                 GUACGUGCUGAGGC 
                   
                   
               
               
                   
                   
                   
                 CUACCACCGUGGCC 
                   
                   
               
               
                   
                   
                   
                 AGCAGACCUGUGAU 
                   
                   
               
               
                   
                   
                   
                 CGGCAUCGGCCUGG 
                   
                   
               
               
                   
                   
                   
                 GCAACGACGUGUUC 
                   
                   
               
               
                   
                   
                   
                 CUGACCGCCCACGC 
                   
                   
               
               
                   
                   
                   
                 UCUGGCCUCCGGUG 
                   
                   
               
               
                   
                   
                   
                 GCCCCGACGCUGCC 
                   
                   
               
               
                   
                   
                   
                 GCCAUCGUGAGAGU 
                   
                   
               
               
                   
                   
                   
                 GACCAUCAACUUCU 
                   
                   
               
               
                   
                   
                   
                 UCAGACAGCCUCAG 
                   
                   
               
               
                   
                   
                   
                 AUGAGACACCUGAG 
                   
                   
               
               
                   
                   
                   
                 CUGGUUCCUGGCCG 
                   
                   
               
               
                   
                   
                   
                 GCGACUUCAACAGA 
                   
                   
               
               
                   
                   
                   
                 AGCCCUGACAGACU 
                   
                   
               
               
                   
                   
                   
                 GGAGAACGACCUGA 
                   
                   
               
               
                   
                   
                   
                 UGACCGAGCACCUG 
                   
                   
               
               
                   
                   
                   
                 GAGAGAGUGGUGGC 
                   
                   
               
               
                   
                   
                   
                 CGUGCUGGCCCCUA 
                   
                   
               
               
                   
                   
                   
                 CCGAGCCUACCCAG 
                   
                   
               
               
                   
                   
                   
                 AUCGGCGGCGGCAU 
                   
                   
               
               
                   
                   
                   
                 CCUGGACUACGGCG 
                   
                   
               
               
                   
                   
                   
                 UGAUCGUGGACAGA 
                   
                   
               
               
                   
                   
                   
                 GCCCCUUACAGCCA 
                   
                   
               
               
                   
                   
                   
                 GAGAGUGGAGGCCC 
                   
                   
               
               
                   
                   
                   
                 UGAGAAACCCUCAG 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAGCGACCA 
                   
                   
               
               
                   
                   
                   
                 CUACCCUGUGGCCU 
                   
                   
               
               
                   
                   
                   
                 UCCUGGCCAGAAGC 
                   
                   
               
               
                   
                   
                   
                 UGC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 101 
                 102 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 211 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 102, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_CdtB_ 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACUCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                   PDTTG NIADYKVMT 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 K_cHis 
                 WNLQGSSASTESKW 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 NVNVRQLLSGTAGV 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 DILMVQEAGAVPTSA 
                 CGGCAACAUCGCAG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 VPTGRHIQPFGVGIPI 
                 ACUACAAGGUGAUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 DEYTWNLGTTSRQDI 
                 ACCUGGAACCUGCA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 RYIYHSAIDVGARRV 
                 GGGAAGCUCCGCCA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 NLAIVSRQRADNVYV 
                 GCACCGAGAGCAAG 
                   
                 UCCCCC 
               
               
                   
                   
                 LRPTTVASRPVIGIGL 
                 UGGAACGUGAACGU 
                   
                 CAGCCC 
               
               
                   
                   
                 GNDVFLTAHALASG 
                 GAGACAGCUCCUGA 
                   
                 CUCCUC 
               
               
                   
                   
                 GPDAAAIVRVTINFFR 
                 GCGGCACCGCCGGC 
                   
                 CCCUUC 
               
               
                   
                   
                 QPQMRHLSWFLAGD 
                 GUCGACAUCCUGAU 
                   
                 CUGCAC 
               
               
                   
                   
                 FNRSPDRLENDLMTE 
                 GGUGCAGGAGGCCG 
                   
                 CCGUAC 
               
               
                   
                   
                 HLERVVAVLAPTEPT 
                 GAGCCGUCCCUACC 
                   
                 CCCCGU 
               
               
                   
                   
                 QIGGGILDYGVIVDR 
                 AGCGCCGUGCCUAC 
                   
                 GGUCUU 
               
               
                   
                   
                 APYSQRVEALRNPQL 
                 CGGCAGACACAUCC 
                   
                 UGAAUA 
               
               
                   
                   
                 ASDHYPVAFLARSCH 
                 AGCCUUUCGGCGUG 
                   
                 AAGUCU 
               
               
                   
                   
                 HHHHH 
                 GGCAUCCCUAUCGA 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CGAGUACACCUGGA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 AUCUCGGCACCACC 
                   
                   
               
               
                   
                   
                   
                 AGCAGACAGGACAU 
                   
                   
               
               
                   
                   
                   
                 CAGAUACAUCUACC 
                   
                   
               
               
                   
                   
                   
                 ACAGCGCCAUCGAC 
                   
                   
               
               
                   
                   
                   
                 GUGGGCGCCAGAAG 
                   
                   
               
               
                   
                   
                   
                 AGUGAACCUGGCCA 
                   
                   
               
               
                   
                   
                   
                 UCGUGAGCAGACAG 
                   
                   
               
               
                   
                   
                   
                 AGAGCCGACAACGU 
                   
                   
               
               
                   
                   
                   
                 CUACCACCGUGGCC 
                   
                   
               
               
                   
                   
                   
                 AGCAGACCUGUGAU 
                   
                   
               
               
                   
                   
                   
                 CGGCAUCGGCCUGG 
                   
                   
               
               
                   
                   
                   
                 GCAACGACGUGUUC 
                   
                   
               
               
                   
                   
                   
                 CUGACCGCCCACGC 
                   
                   
               
               
                   
                   
                   
                 UCUGGCCUCCGGUG 
                   
                   
               
               
                   
                   
                   
                 GCCCCGACGCUGCC 
                   
                   
               
               
                   
                   
                   
                 GCCAUCGUGAGAGU 
                   
                   
               
               
                   
                   
                   
                 GACCAUCAACUUCU 
                   
                   
               
               
                   
                   
                   
                 UCAGACAGCCUCAG 
                   
                   
               
               
                   
                   
                   
                 AUGAGACACCUGAG 
                   
                   
               
               
                   
                   
                   
                 CUGGUUCCUGGCCG 
                   
                   
               
               
                   
                   
                   
                 GCGACUUCAACAGA 
                   
                   
               
               
                   
                   
                   
                 AGCCCUGACAGACU 
                   
                   
               
               
                   
                   
                   
                 GGAGAACGACCUGA 
                   
                   
               
               
                   
                   
                   
                 UGACCGAGCACCUG 
                   
                   
               
               
                   
                   
                   
                 GAGAGAGUGGUGGC 
                   
                   
               
               
                   
                   
                   
                 CGUGCUGGCCCCUA 
                   
                   
               
               
                   
                   
                   
                 CCGAGCCUACCCAG 
                   
                   
               
               
                   
                   
                   
                 AUCGGCGGCGGCAU 
                   
                   
               
               
                   
                   
                   
                 CCUGGACUACGGCG 
                   
                   
               
               
                   
                   
                   
                 UGAUCGUGGACAGA 
                   
                   
               
               
                   
                   
                   
                 GCCCCUUACAGCCA 
                   
                   
               
               
                   
                   
                   
                 GAGAGUGGAGGCCC 
                   
                   
               
               
                   
                   
                   
                 UGAGAAACCCUCAG 
                   
                   
               
               
                   
                   
                   
                 CUGGCCAGCGACCA 
                   
                   
               
               
                   
                   
                   
                 CUACCCUGUGGCCU 
                   
                   
               
               
                   
                   
                   
                 UCCUGGCCAGAAGC 
                   
                   
               
               
                   
                   
                   
                 UGCCAUCACCACCA 
                   
                   
               
               
                   
                   
                   
                 CCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 103 
                 104 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 212 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 104, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpL_ 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACGCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK 
                   PDTTG GAYVENREA 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 YNLASDQMEFMLRV 
                 UGCUCCUUCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 GYNSDMGAGIMLTN 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 TYTLQRDDELKHGY 
                 CGGCGGCGCCUACG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NEIEGWYPLFKPTDK 
                 UGGAGAACAGAGAG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 LTIQPGGLINDKSIGS 
                 GCCUACAACCUGGC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 GGAVYLDINYKFTP 
                 CAGCGACCAGAUGG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 WFNLTVRNRYNHNN 
                 AGUUCAUGCUGAGA 
                   
                 UCCCCC 
               
               
                   
                   
                 YSSTDLNGELDNNDS 
                 GUGGGCUACAACAG 
                   
                 CAGCCC 
               
               
                   
                   
                 YEIGNYWNFIITDKFS 
                 CGACAUGGGCGCCG 
                   
                 CUCCUC 
               
               
                   
                   
                 YTFEPHYFYNVNDFN 
                 GCAUCAUGCUUACC 
                   
                 CCCUUC 
               
               
                   
                   
                 SSNGTKHHWEITNTF 
                 AACACCUACACCCU 
                   
                 CUGCAC 
               
               
                   
                   
                 RYRINEHWLPYFELR 
                 GCAGAGAGACGACG 
                   
                 CCGUAC 
               
               
                   
                   
                 WLDRNVGLYHREQN 
                 AGCUGAAGCACGGC 
                   
                 CCCCGU 
               
               
                   
                   
                 QIRIGAKYFF 
                 UACAACGAGAUCGA 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 GGGCUGGUACCCUC 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 UGUUCAAGCCUACC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 GACAAGCUGACCAU 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CCAGCCUGGCGGCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 UGAUCAACGACAAG 
                   
                   
               
               
                   
                   
                   
                 AGCAUCGGCUCUGG 
                   
                   
               
               
                   
                   
                   
                 CGGUGCCGUGUACC 
                   
                   
               
               
                   
                   
                   
                 UGGACAUCAACUAC 
                   
                   
               
               
                   
                   
                   
                 AAGUUCACCCCUUG 
                   
                   
               
               
                   
                   
                   
                 GUUCAACCUGACCG 
                   
                   
               
               
                   
                   
                   
                 UGAGAAACAGAUAC 
                   
                   
               
               
                   
                   
                   
                 AACCACAACAACUA 
                   
                   
               
               
                   
                   
                   
                 CAGCAGCACCGACC 
                   
                   
               
               
                   
                   
                   
                 UGAACGGCGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GACAACAACGACAG 
                   
                   
               
               
                   
                   
                   
                 CUACGAGAUUGGCA 
                   
                   
               
               
                   
                   
                   
                 ACUACUGGAACUUC 
                   
                   
               
               
                   
                   
                   
                 AUCAUCACCGAUAA 
                   
                   
               
               
                   
                   
                   
                 GUUCAGCUACACCU 
                   
                   
               
               
                   
                   
                   
                 UCGAGCCUCACUAC 
                   
                   
               
               
                   
                   
                   
                 UUCUACAACGUGAA 
                   
                   
               
               
                   
                   
                   
                 CGACUUCAAUAGUA 
                   
                   
               
               
                   
                   
                   
                 GCAACGGCACCAAG 
                   
                   
               
               
                   
                   
                   
                 CACCACUGGGAGAU 
                   
                   
               
               
                   
                   
                   
                 CACCAACACGUUCA 
                   
                   
               
               
                   
                   
                   
                 GAUACAGAAUCAAC 
                   
                   
               
               
                   
                   
                   
                 GAGCACUGGCUUCC 
                   
                   
               
               
                   
                   
                   
                 UUACUUCGAGCUGA 
                   
                   
               
               
                   
                   
                   
                 GGUGGCUGGACAGA 
                   
                   
               
               
                   
                   
                   
                 AACGUGGGCCUGUA 
                   
                   
               
               
                   
                   
                   
                 CCACAGAGAGCAGA 
                   
                   
               
               
                   
                   
                   
                 ACCAGAUCAGAAUC 
                   
                   
               
               
                   
                   
                   
                 GGCGCCAAGUACUU 
                   
                   
               
               
                   
                   
                   
                 CUUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 105 
                 106 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 213 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 106, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpL_ 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACGCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK_cHis 
                   PDTTG GAYVENREA 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 YNLASDQMEFMLRV 
                 UGCUCCUUCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 GYNSDMGAGIMLTN 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 TYTLQRDDELKHGY 
                 CGGCGGCGCCUACG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NEIEGWYPLFKPTDK 
                 UGGAGAACAGAGAG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 LTIQPGGLINDKSIGS 
                 GCCUACAACCUGGC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 GGAVYLDINYKFTP 
                 CAGCGACCAGAUGG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 WFNLTVRNRYNHNN 
                 AGUUCAUGCUGAGA 
                   
                 UCCCCC 
               
               
                   
                   
                 YSSTDLNGELDNNDS 
                 GUGGGCUACAACAG 
                   
                 CAGCCC 
               
               
                   
                   
                 YEIGNYWNFIITDKFS 
                 CGACAUGGGCGCCG 
                   
                 CUCCUC 
               
               
                   
                   
                 YTFEPHYFYNVNDFN 
                 GCAUCAUGCUUACC 
                   
                 CCCUUC 
               
               
                   
                   
                 SSNGTKHHWEITNTF 
                 AACACCUACACCCU 
                   
                 CUGCAC 
               
               
                   
                   
                 RYRINEHWLPYFELR 
                 GCAGAGAGACGACG 
                   
                 CCGUAC 
               
               
                   
                   
                 WLDRNVGLYHREQN 
                 AGCUGAAGCACGGC 
                   
                 CCCCGU 
               
               
                   
                   
                 QIRIGAKYFFHHHHH 
                 UACAACGAGAUCGA 
                   
                 GGUCUU 
               
               
                   
                   
                 H 
                 GGGCUGGUACCCUC 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 UGUUCAAGCCUACC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 GACAAGCUGACCAU 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CCAGCCUGGCGGCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 UGAUCAACGACAAG 
                   
                   
               
               
                   
                   
                   
                 AGCAUCGGCUCUGG 
                   
                   
               
               
                   
                   
                   
                 CGGUGCCGUGUACC 
                   
                   
               
               
                   
                   
                   
                 UGGACAUCAACUAC 
                   
                   
               
               
                   
                   
                   
                 AAGUUCACCCCUUG 
                   
                   
               
               
                   
                   
                   
                 GUUCAACCUGACCG 
                   
                   
               
               
                   
                   
                   
                 UGAGAAACAGAUAC 
                   
                   
               
               
                   
                   
                   
                 AACCACAACAACUA 
                   
                   
               
               
                   
                   
                   
                 CAGCAGCACCGACC 
                   
                   
               
               
                   
                   
                   
                 UGAACGGCGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GACAACAACGACAG 
                   
                   
               
               
                   
                   
                   
                 CUACGAGAUUGGCA 
                   
                   
               
               
                   
                   
                   
                 ACUACUGGAACUUC 
                   
                   
               
               
                   
                   
                   
                 AUCAUCACCGAUAA 
                   
                   
               
               
                   
                   
                   
                 GUUCAGCUACACCU 
                   
                   
               
               
                   
                   
                   
                 UCGAGCCUCACUAC 
                   
                   
               
               
                   
                   
                   
                 UUCUACAACGUGAA 
                   
                   
               
               
                   
                   
                   
                 CGACUUCAAUAGUA 
                   
                   
               
               
                   
                   
                   
                 GCAACGGCACCAAG 
                   
                   
               
               
                   
                   
                   
                 CACCACUGGGAGAU 
                   
                   
               
               
                   
                   
                   
                 CACCAACACGUUCA 
                   
                   
               
               
                   
                   
                   
                 GAUACAGAAUCAAC 
                   
                   
               
               
                   
                   
                   
                 GAGCACUGGCUUCC 
                   
                   
               
               
                   
                   
                   
                 UUACUUCGAGCUGA 
                   
                   
               
               
                   
                   
                   
                 GGUGGCUGGACAGA 
                   
                   
               
               
                   
                   
                   
                 AACGUGGGCCUGUA 
                   
                   
               
               
                   
                   
                   
                 CCACAGAGAGCAGA 
                   
                   
               
               
                   
                   
                   
                 ACCAGAUCAGAAUC 
                   
                   
               
               
                   
                   
                   
                 GGCGCCAAGUACUU 
                   
                   
               
               
                   
                   
                   
                 CUUCCACCAUCACC 
                   
                   
               
               
                   
                   
                   
                 ACCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 107 
                 108 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 214 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 108, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpL_ 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACGCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                   PDTTG GAYVENREA 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 K 
                 YNLASDQMEFMLRV 
                 UGCUCCUUCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 GYNSDMGAGIMLTN 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 TYTLQRDDELKHGY 
                 CGGCGGCGCCUACG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NEIEGWYPLFKPTDK 
                 UGGAGAACAGAGAG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 LTIQPGGLINDKSIGS 
                 GCCUACAACCUGGC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 GGAVYLDINYKFTP 
                 CAGCGACCAGAUGG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 WFNLAVRNRYNHNN 
                 AGUUCAUGCUGAGA 
                   
                 UCCCCC 
               
               
                   
                   
                 YASTDLNGELDNNDS 
                 GUGGGCUACAACAG 
                   
                 CAGCCC 
               
               
                   
                   
                 YEIGNYWNFIITDKFS 
                 CGACAUGGGCGCCG 
                   
                 CUCCUC 
               
               
                   
                   
                 YTFEPHYFYNVNDFN 
                 GCAUCAUGCUUACC 
                   
                 CCCUUC 
               
               
                   
                   
                 SSNGAKHHWEITNTF 
                 AACACCUACACCCU 
                   
                 CUGCAC 
               
               
                   
                   
                 RYRINEHWLPYFELR 
                 GCAGAGAGACGACG 
                   
                 CCGUAC 
               
               
                   
                   
                 WLDRNVGLYHREQN 
                 AGCUGAAGCACGGC 
                   
                 CCCCGU 
               
               
                   
                   
                 QIRIGAKYFF 
                 UACAACGAGAUCGA 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 GGGCUGGUACCCUC 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 UGUUCAAGCCUACC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 GACAAGCUGACCAU 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CCAGCCUGGCGGCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 UGAUCAACGACAAG 
                   
                   
               
               
                   
                   
                   
                 AGCAUCGGCUCUGG 
                   
                   
               
               
                   
                   
                   
                 CGGUGCCGUGUACC 
                   
                   
               
               
                   
                   
                   
                 UGGACAUCAACUAC 
                   
                   
               
               
                   
                   
                   
                 AAGUUCACCCCUUG 
                   
                   
               
               
                   
                   
                   
                 GUUCAACCUGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGAGAAACAGAUAC 
                   
                   
               
               
                   
                   
                   
                 AACCACAACAACUA 
                   
                   
               
               
                   
                   
                   
                 CGCAAGCACCGACC 
                   
                   
               
               
                   
                   
                   
                 UGAACGGCGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GACAACAACGACAG 
                   
                   
               
               
                   
                   
                   
                 CUACGAGAUUGGCA 
                   
                   
               
               
                   
                   
                   
                 ACUACUGGAACUUC 
                   
                   
               
               
                   
                   
                   
                 AUCAUCACCGAUAA 
                   
                   
               
               
                   
                   
                   
                 GUUCAGCUACACCU 
                   
                   
               
               
                   
                   
                   
                 UCGAGCCUCACUAC 
                   
                   
               
               
                   
                   
                   
                 UUCUACAACGUGAA 
                   
                   
               
               
                   
                   
                   
                 CGACUUCAAUAGUA 
                   
                   
               
               
                   
                   
                   
                 GCAACGGCGCCAAG 
                   
                   
               
               
                   
                   
                   
                 CACCACUGGGAGAU 
                   
                   
               
               
                   
                   
                   
                 CACCAACACGUUCA 
                   
                   
               
               
                   
                   
                   
                 GAUACAGAAUCAAC 
                   
                   
               
               
                   
                   
                   
                 GAGCACUGGCUUCC 
                   
                   
               
               
                   
                   
                   
                 UUACUUCGAGCUGA 
                   
                   
               
               
                   
                   
                   
                 GGUGGCUGGACAGA 
                   
                   
               
               
                   
                   
                   
                 AACGUGGGCCUGUA 
                   
                   
               
               
                   
                   
                   
                 CCACAGAGAGCAGA 
                   
                   
               
               
                   
                   
                   
                 ACCAGAUCAGAAUC 
                   
                   
               
               
                   
                   
                   
                 GGCGCCAAGUACUU 
                   
                   
               
               
                   
                   
                   
                 CUUC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 109 
                 110 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 215 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 110, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_OmpL_ 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACGCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 NGM_nIg 
                   PDTTG GAYVENREA 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 K_cHis 
                 YNLASDQMEFMLRV 
                 UGCUCCUUCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 GYNSDMGAGIMLTN 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 TYTLQRDDELKHGY 
                 CGGCGGCGCCUACG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 NEIEGWYPLFKPTDK 
                 UGGAGAACAGAGAG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 LTIQPGGLINDKSIGS 
                 GCCUACAACCUGGC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 GGAVYLDINYKFTP 
                 CAGCGACCAGAUGG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 WFNLAVRNRYNHNN 
                 AGUUCAUGCUGAGA 
                   
                 UCCCCC 
               
               
                   
                   
                 YASTDLNGELDNNDS 
                 GUGGGCUACAACAG 
                   
                 CAGCCC 
               
               
                   
                   
                 YEIGNYWNFIITDKFS 
                 CGACAUGGGCGCCG 
                   
                 CUCCUC 
               
               
                   
                   
                 YTFEPHYFYNVNDFN 
                 GCAUCAUGCUUACC 
                   
                 CCCUUC 
               
               
                   
                   
                 SSNGAKHHWEITNTF 
                 AACACCUACACCCU 
                   
                 CUGCAC 
               
               
                   
                   
                 RYRINEHWLPYFELR 
                 GCAGAGAGACGACG 
                   
                 CCGUAC 
               
               
                   
                   
                 WLDRNVGLYHREQN 
                 AGCUGAAGCACGGC 
                   
                 CCCCGU 
               
               
                   
                   
                 QIRIGAKYFFHHHHH 
                 UACAACGAGAUCGA 
                   
                 GGUCUU 
               
               
                   
                   
                 H 
                 GGGCUGGUACCCUC 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 UGUUCAAGCCUACC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 GACAAGCUGACCAU 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CCAGCCUGGCGGCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 UGAUCAACGACAAG 
                   
                   
               
               
                   
                   
                   
                 AGCAUCGGCUCUGG 
                   
                   
               
               
                   
                   
                   
                 CGGUGCCGUGUACC 
                   
                   
               
               
                   
                   
                   
                 UGGACAUCAACUAC 
                   
                   
               
               
                   
                   
                   
                 AAGUUCACCCCUUG 
                   
                   
               
               
                   
                   
                   
                 GUUCAACCUGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGAGAAACAGAUAC 
                   
                   
               
               
                   
                   
                   
                 AACCACAACAACUA 
                   
                   
               
               
                   
                   
                   
                 CGCAAGCACCGACC 
                   
                   
               
               
                   
                   
                   
                 UGAACGGCGAGCUG 
                   
                   
               
               
                   
                   
                   
                 GACAACAACGACAG 
                   
                   
               
               
                   
                   
                   
                 CUACGAGAUUGGCA 
                   
                   
               
               
                   
                   
                   
                 ACUACUGGAACUUC 
                   
                   
               
               
                   
                   
                   
                 AUCAUCACCGAUAA 
                   
                   
               
               
                   
                   
                   
                 GUUCAGCUACACCU 
                   
                   
               
               
                   
                   
                   
                 UCGAGCCUCACUAC 
                   
                   
               
               
                   
                   
                   
                 UUCUACAACGUGAA 
                   
                   
               
               
                   
                   
                   
                 CGACUUCAAUAGUA 
                   
                   
               
               
                   
                   
                   
                 GCAACGGCGCCAAG 
                   
                   
               
               
                   
                   
                   
                 CACCACUGGGAGAU 
                   
                   
               
               
                   
                   
                   
                 CACCAACACGUUCA 
                   
                   
               
               
                   
                   
                   
                 GAUACAGAAUCAAC 
                   
                   
               
               
                   
                   
                   
                 GAGCACUGGCUUCC 
                   
                   
               
               
                   
                   
                   
                 UUACUUCGAGCUGA 
                   
                   
               
               
                   
                   
                   
                 GGUGGCUGGACAGA 
                   
                   
               
               
                   
                   
                   
                 AACGUGGGCCUGUA 
                   
                   
               
               
                   
                   
                   
                 CCACAGAGAGCAGA 
                   
                   
               
               
                   
                   
                   
                 ACCAGAUCAGAAUC 
                   
                   
               
               
                   
                   
                   
                 GGCGCCAAGUACUU 
                   
                   
               
               
                   
                   
                   
                 CUUCCACCAUCACC 
                   
                   
               
               
                   
                   
                   
                 ACCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 111 
                 112 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 216 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 112, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_PltA_nI 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAAACCCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 gK 
                   PDTTG VDFVYRVDST 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 PPDVIFRDGFSLLGYN 
                 UGCUGCUGCUCUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 RNFQQFISGRSCSGGS 
                 CUGCCUGACACAAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SDSRYIATTSSVNQT 
                 CGGCGUGGACUUCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 YAIARAYYSRSTFKG 
                 UGUACAGAGUGGAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 NLYRYQIRADNNFYS 
                 AGCACCCCUCCUGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LLPSITYLETQGGHFN 
                 CGUGAUCUUCAGAG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 AYEKTMMRLQREYV 
                 ACGGCUUCAGCCUG 
                   
                 UCCCCC 
               
               
                   
                   
                 STLSILPENIQKAVAL 
                 CUGGGCUACAACAG 
                   
                 CAGCCC 
               
               
                   
                   
                 VYDSATGLVKDGVS 
                 AAACUUCCAGCAGU 
                   
                 CUCCUC 
               
               
                   
                   
                 TMNASYLGLSTTSNP 
                 UCAUCAGCGGCAGA 
                   
                 CCCUUC 
               
               
                   
                   
                 GVIPFLPEPQTYTQQR 
                 AGCUGCAGCGGCGG 
                   
                 CUGCAC 
               
               
                   
                   
                 IDAFGPLISSCFSIGSV 
                 UAGCAGCGAUAGCA 
                   
                 CCGUAC 
               
               
                   
                   
                 CHSHRGQRADVYNM 
                 GAUACAUCGCCACC 
                   
                 CCCCGU 
               
               
                   
                   
                 SFYDARPVIELILSK 
                 ACCAGCAGCGUGAA 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 CCAGACCUACGCCA 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 UCGCCAGAGCCUAC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 UACAGCAGAAGCAC 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CUUCAAGGGCAACC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 UGUACAGAUACCAG 
                   
                   
               
               
                   
                   
                   
                 AUCAGAGCCGACAA 
                   
                   
               
               
                   
                   
                   
                 CAACUUCUACAGCC 
                   
                   
               
               
                   
                   
                   
                 UGCUGCCUAGCAUC 
                   
                   
               
               
                   
                   
                   
                 ACCUACCUGGAAAC 
                   
                   
               
               
                   
                   
                   
                 GCAGGGCGGCCACU 
                   
                   
               
               
                   
                   
                   
                 UCAACGCCUACGAG 
                   
                   
               
               
                   
                   
                   
                 AAGACCAUGAUGAG 
                   
                   
               
               
                   
                   
                   
                 ACUGCAGAGAGAGU 
                   
                   
               
               
                   
                   
                   
                 ACGUGAGCACCCUG 
                   
                   
               
               
                   
                   
                   
                 UCAAUCCUGCCCGA 
                   
                   
               
               
                   
                   
                   
                 GAACAUCCAGAAGG 
                   
                   
               
               
                   
                   
                   
                 CCGUGGCCCUGGUG 
                   
                   
               
               
                   
                   
                   
                 UACGACAGCGCCAC 
                   
                   
               
               
                   
                   
                   
                 CGGCCUGGUGAAGG 
                   
                   
               
               
                   
                   
                   
                 ACGGCGUGAGCACC 
                   
                   
               
               
                   
                   
                   
                 AUGAACGCCAGCUA 
                   
                   
               
               
                   
                   
                   
                 CCUCGGGCUGAGCA 
                   
                   
               
               
                   
                   
                   
                 CAACCAGCAACCCU 
                   
                   
               
               
                   
                   
                   
                 GGCGUGAUCCCUUU 
                   
                   
               
               
                   
                   
                   
                 CCUGCCUGAGCCUC 
                   
                   
               
               
                   
                   
                   
                 AGACCUACACCCAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGAAUCGACGC 
                   
                   
               
               
                   
                   
                   
                 CUUCGGCCCUCUGA 
                   
                   
               
               
                   
                   
                   
                 UCAGCAGCUGCUUC 
                   
                   
               
               
                   
                   
                   
                 AGCAUCGGCAGCGU 
                   
                   
               
               
                   
                   
                   
                 GUGCCACAGCCACA 
                   
                   
               
               
                   
                   
                   
                 GAGGCCAGAGAGCC 
                   
                   
               
               
                   
                   
                   
                 GACGUGUACAACAU 
                   
                   
               
               
                   
                   
                   
                 GAGCUUCUACGACG 
                   
                   
               
               
                   
                   
                   
                 CCAGACCUGUGAUC 
                   
                   
               
               
                   
                   
                   
                 GAGCUGAUCCUGUC 
                   
                   
               
               
                   
                   
                   
                 CAAG 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 113 
                 114 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 217 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 114, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_PltA_nI 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAAACCCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 gK_cHis 
                   PDTTG VDFVYRVDST 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 PPDVIFRDGFSLLGYN 
                 UGCUGCUGCUCUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 RNFQQFISGRSCSGGS 
                 CUGCCUGACACAAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SDSRYIATTSSVNQT 
                 CGGCGUGGACUUCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 YAIARAYYSRSTFKG 
                 UGUACAGAGUGGAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 NLYRYQIRADNNFYS 
                 AGCACCCCUCCUGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LLPSITYLETQGGHFN 
                 CGUGAUCUUCAGAG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 AYEKTMMRLQREYV 
                 ACGGCUUCAGCCUG 
                   
                 UCCCCC 
               
               
                   
                   
                 STLSILPENIQKAVAL 
                 CUGGGCUACAACAG 
                   
                 CAGCCC 
               
               
                   
                   
                 VYDSATGLVKDGVS 
                 AAACUUCCAGCAGU 
                   
                 CUCCUC 
               
               
                   
                   
                 TMNASYLGLSTTSNP 
                 UCAUCAGCGGCAGA 
                   
                 CCCUUC 
               
               
                   
                   
                 GVIPFLPEPQTYTQQR 
                 AGCUGCAGCGGCGG 
                   
                 CUGCAC 
               
               
                   
                   
                 IDAFGPLISSCFSIGSV 
                 UAGCAGCGAUAGCA 
                   
                 CCGUAC 
               
               
                   
                   
                 CHSHRGQRADVYNM 
                 GAUACAUCGCCACC 
                   
                 CCCCGU 
               
               
                   
                   
                 SFYDARPVIELILSKH 
                 ACCAGCAGCGUGAA 
                   
                 GGUCUU 
               
               
                   
                   
                 HHHHH 
                 CCAGACCUACGCCA 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 UCGCCAGAGCCUAC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 UACAGCAGAAGCAC 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CUUCAAGGGCAACC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 UGUACAGAUACCAG 
                   
                   
               
               
                   
                   
                   
                 AUCAGAGCCGACAA 
                   
                   
               
               
                   
                   
                   
                 CAACUUCUACAGCC 
                   
                   
               
               
                   
                   
                   
                 UGCUGCCUAGCAUC 
                   
                   
               
               
                   
                   
                   
                 ACCUACCUGGAAAC 
                   
                   
               
               
                   
                   
                   
                 GCAGGGCGGCCACU 
                   
                   
               
               
                   
                   
                   
                 UCAACGCCUACGAG 
                   
                   
               
               
                   
                   
                   
                 AAGACCAUGAUGAG 
                   
                   
               
               
                   
                   
                   
                 ACUGCAGAGAGAGU 
                   
                   
               
               
                   
                   
                   
                 ACGUGAGCACCCUG 
                   
                   
               
               
                   
                   
                   
                 UCAAUCCUGCCCGA 
                   
                   
               
               
                   
                   
                   
                 GAACAUCCAGAAGG 
                   
                   
               
               
                   
                   
                   
                 CCGUGGCCCUGGUG 
                   
                   
               
               
                   
                   
                   
                 UACGACAGCGCCAC 
                   
                   
               
               
                   
                   
                   
                 CGGCCUGGUGAAGG 
                   
                   
               
               
                   
                   
                   
                 ACGGCGUGAGCACC 
                   
                   
               
               
                   
                   
                   
                 AUGAACGCCAGCUA 
                   
                   
               
               
                   
                   
                   
                 CCUCGGGCUGAGCA 
                   
                   
               
               
                   
                   
                   
                 CAACCAGCAACCCU 
                   
                   
               
               
                   
                   
                   
                 GGCGUGAUCCCUUU 
                   
                   
               
               
                   
                   
                   
                 CCUGCCUGAGCCUC 
                   
                   
               
               
                   
                   
                   
                 AGACCUACACCCAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGAAUCGACGC 
                   
                   
               
               
                   
                   
                   
                 CUUCGGCCCUCUGA 
                   
                   
               
               
                   
                   
                   
                 UCAGCAGCUGCUUC 
                   
                   
               
               
                   
                   
                   
                 AGCAUCGGCAGCGU 
                   
                   
               
               
                   
                   
                   
                 GUGCCACAGCCACA 
                   
                   
               
               
                   
                   
                   
                 GAGGCCAGAGAGCC 
                   
                   
               
               
                   
                   
                   
                 GACGUGUACAACAU 
                   
                   
               
               
                   
                   
                   
                 GAGCUUCUACGACG 
                   
                   
               
               
                   
                   
                   
                 CCAGACCUGUGAUC 
                   
                   
               
               
                   
                   
                   
                 GAGCUGAUCCUGUC 
                   
                   
               
               
                   
                   
                   
                 CAAGCACCACCACC 
                   
                   
               
               
                   
                   
                   
                 AUCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 115 
                 116 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 218 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 116, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_PltA 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAAACCCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 _NGM_nI 
                   PDTTG VDFVYRVDST 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 gK 
                 PPDVIFRDGFSLLGYN 
                 UGCUGCUGCUCUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 RNFQQFISGRSCSGGS 
                 CUGCCUGACACAAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SDSRYIATTSSVNQA 
                 CGGCGUGGACUUCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 YAIARAYYSRSTFKG 
                 UGUACAGAGUGGAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 NLYRYQIRADNNFYS 
                 AGCACCCCUCCUGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LLPSITYLETQGGHFN 
                 CGUGAUCUUCAGAG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 AYEKTMMRLQREYV 
                 ACGGCUUCAGCCUG 
                   
                 UCCCCC 
               
               
                   
                   
                 STLSILPENIQKAVAL 
                 CUGGGCUACAACAG 
                   
                 CAGCCC 
               
               
                   
                   
                 VYDSATGLVKDGVS 
                 AAACUUCCAGCAGU 
                   
                 CUCCUC 
               
               
                   
                   
                 TMNASYLGLSTTSNP 
                 UCAUCAGCGGCAGA 
                   
                 CCCUUC 
               
               
                   
                   
                 GVIPFLPEPQTYTQQR 
                 AGCUGCAGCGGCGG 
                   
                 CUGCAC 
               
               
                   
                   
                 IDAFGPLISSCFSIGSV 
                 UAGCAGCGAUAGCA 
                   
                 CCGUAC 
               
               
                   
                   
                 CHSHRGQRADVYNM 
                 GAUACAUCGCCACC 
                   
                 CCCCGU 
               
               
                   
                   
                 SFYDARPVIELILSK 
                 ACCAGCAGCGUGAA 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 CCAGGCCUACGCCA 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 UCGCCAGAGCCUAC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 UACAGCAGAAGCAC 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CUUCAAGGGCAACC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 UGUACAGAUACCAG 
                   
                   
               
               
                   
                   
                   
                 AUCAGAGCCGACAA 
                   
                   
               
               
                   
                   
                   
                 CAACUUCUACAGCC 
                   
                   
               
               
                   
                   
                   
                 UGCUGCCUAGCAUC 
                   
                   
               
               
                   
                   
                   
                 ACCUACCUGGAAAC 
                   
                   
               
               
                   
                   
                   
                 GCAGGGCGGCCACU 
                   
                   
               
               
                   
                   
                   
                 UCAACGCCUACGAG 
                   
                   
               
               
                   
                   
                   
                 AAGACCAUGAUGAG 
                   
                   
               
               
                   
                   
                   
                 ACUGCAGAGAGAGU 
                   
                   
               
               
                   
                   
                   
                 ACGUGAGCACCCUG 
                   
                   
               
               
                   
                   
                   
                 UCAAUCCUGCCCGA 
                   
                   
               
               
                   
                   
                   
                 GAACAUCCAGAAGG 
                   
                   
               
               
                   
                   
                   
                 CCGUGGCCCUGGUG 
                   
                   
               
               
                   
                   
                   
                 UACGACAGCGCCAC 
                   
                   
               
               
                   
                   
                   
                 CGGCCUGGUGAAGG 
                   
                   
               
               
                   
                   
                   
                 ACGGCGUGAGCACC 
                   
                   
               
               
                   
                   
                   
                 AUGAACGCCAGCUA 
                   
                   
               
               
                   
                   
                   
                 CCUCGGGCUGAGCA 
                   
                   
               
               
                   
                   
                   
                 CAACCAGCAACCCU 
                   
                   
               
               
                   
                   
                   
                 GGCGUGAUCCCUUU 
                   
                   
               
               
                   
                   
                   
                 CCUGCCUGAGCCUC 
                   
                   
               
               
                   
                   
                   
                 AGACCUACACCCAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGAAUCGACGC 
                   
                   
               
               
                   
                   
                   
                 CUUCGGCCCUCUGA 
                   
                   
               
               
                   
                   
                   
                 UCAGCAGCUGCUUC 
                   
                   
               
               
                   
                   
                   
                 AGCAUCGGCAGCGU 
                   
                   
               
               
                   
                   
                   
                 GUGCCACAGCCACA 
                   
                   
               
               
                   
                   
                   
                 GAGGCCAGAGAGCC 
                   
                   
               
               
                   
                   
                   
                 GACGUGUACAACAU 
                   
                   
               
               
                   
                   
                   
                 GAGCUUCUACGACG 
                   
                   
               
               
                   
                   
                   
                 CCAGACCUGUGAUC 
                   
                   
               
               
                   
                   
                   
                 GAGCUGAUCCUGUC 
                   
                   
               
               
                   
                   
                   
                 CAAG 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 117 
                 118 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 219 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 118, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_PltA 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAAACCCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 _NGM_nI 
                   PDTTG VDFVYRVDST 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 gK_cHis 
                 PPDVIFRDGFSLLGYN 
                 UGCUGCUGCUCUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 RNFQQFISGRSCSGGS 
                 CUGCCUGACACAAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SDSRYIATTSSVNQA 
                 CGGCGUGGACUUCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 YAIARAYYSRSTFKG 
                 UGUACAGAGUGGAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 NLYRYQIRADNNFYS 
                 AGCACCCCUCCUGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 LLPSITYLETQGGHFN 
                 CGUGAUCUUCAGAG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 AYEKTMMRLQREYV 
                 ACGGCUUCAGCCUG 
                   
                 UCCCCC 
               
               
                   
                   
                 STLSILPENIQKAVAL 
                 CUGGGCUACAACAG 
                   
                 CAGCCC 
               
               
                   
                   
                 VYDSATGLVKDGVS 
                 AAACUUCCAGCAGU 
                   
                 CUCCUC 
               
               
                   
                   
                 TMNASYLGLSTTSNP 
                 UCAUCAGCGGCAGA 
                   
                 CCCUUC 
               
               
                   
                   
                 GVIPFLPEPQTYTQQR 
                 AGCUGCAGCGGCGG 
                   
                 CUGCAC 
               
               
                   
                   
                 IDAFGPLISSCFSIGSV 
                 UAGCAGCGAUAGCA 
                   
                 CCGUAC 
               
               
                   
                   
                 CHSHRGQRADVYNM 
                 GAUACAUCGCCACC 
                   
                 CCCCGU 
               
               
                   
                   
                 SFYDARPVIELILSKH 
                 ACCAGCAGCGUGAA 
                   
                 GGUCUU 
               
               
                   
                   
                 HHHHH 
                 CCAGGCCUACGCCA 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 UCGCCAGAGCCUAC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 UACAGCAGAAGCAC 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CUUCAAGGGCAACC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 UGUACAGAUACCAG 
                   
                   
               
               
                   
                   
                   
                 AUCAGAGCCGACAA 
                   
                   
               
               
                   
                   
                   
                 CAACUUCUACAGCC 
                   
                   
               
               
                   
                   
                   
                 UGCUGCCUAGCAUC 
                   
                   
               
               
                   
                   
                   
                 ACCUACCUGGAAAC 
                   
                   
               
               
                   
                   
                   
                 GCAGGGCGGCCACU 
                   
                   
               
               
                   
                   
                   
                 UCAACGCCUACGAG 
                   
                   
               
               
                   
                   
                   
                 AAGACCAUGAUGAG 
                   
                   
               
               
                   
                   
                   
                 ACUGCAGAGAGAGU 
                   
                   
               
               
                   
                   
                   
                 ACGUGAGCACCCUG 
                   
                   
               
               
                   
                   
                   
                 UCAAUCCUGCCCGA 
                   
                   
               
               
                   
                   
                   
                 GAACAUCCAGAAGG 
                   
                   
               
               
                   
                   
                   
                 CCGUGGCCCUGGUG 
                   
                   
               
               
                   
                   
                   
                 UACGACAGCGCCAC 
                   
                   
               
               
                   
                   
                   
                 CGGCCUGGUGAAGG 
                   
                   
               
               
                   
                   
                   
                 ACGGCGUGAGCACC 
                   
                   
               
               
                   
                   
                   
                 AUGAACGCCAGCUA 
                   
                   
               
               
                   
                   
                   
                 CCUCGGGCUGAGCA 
                   
                   
               
               
                   
                   
                   
                 CAACCAGCAACCCU 
                   
                   
               
               
                   
                   
                   
                 GGCGUGAUCCCUUU 
                   
                   
               
               
                   
                   
                   
                 CCUGCCUGAGCCUC 
                   
                   
               
               
                   
                   
                   
                 AGACCUACACCCAG 
                   
                   
               
               
                   
                   
                   
                 CAGAGAAUCGACGC 
                   
                   
               
               
                   
                   
                   
                 CUUCGGCCCUCUGA 
                   
                   
               
               
                   
                   
                   
                 UCAGCAGCUGCUUC 
                   
                   
               
               
                   
                   
                   
                 AGCAUCGGCAGCGU 
                   
                   
               
               
                   
                   
                   
                 GUGCCACAGCCACA 
                   
                   
               
               
                   
                   
                   
                 GACGUGUACAACAU 
                   
                   
               
               
                   
                   
                   
                 GAGCUUCUACGACG 
                   
                   
               
               
                   
                   
                   
                 CCAGACCUGUGAUC 
                   
                   
               
               
                   
                   
                   
                 GAGCUGAUCCUGUC 
                   
                   
               
               
                   
                   
                   
                 CAAGCACCACCACC 
                   
                   
               
               
                   
                   
                   
                 AUCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 119 
                 120 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 220 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 120, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_PltB_nI 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACACCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 gK 
                   PDTTG EWTGDNTNA 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 YYSDEVISELHVGQI 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 DTSPYFCIKTVKANG 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SGTPVVACAVSKQSI 
                 UGGCGAGUGGACCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 WAPSFKELLDQARYF 
                 GCGACAACACCAAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 YSTGQSVRIHVQKNI 
                 GCCUACUACAGCGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 WTYPLFVNTFSANAL 
                 CGAGGUGAUCUCCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 VGLSSCSATQCFGPK 
                 AGCUGCACGUGGGA 
                   
                 UCCCCC 
               
               
                   
                   
                   
                 CAGAUCGACACCAG 
                   
                 CAGCCC 
               
               
                   
                   
                   
                 CCCUUACUUCUGCA 
                   
                 CUCCUC 
               
               
                   
                   
                   
                 UCAAGACCGUGAAG 
                   
                 CCCUUC 
               
               
                   
                   
                   
                 GCCAACGGCAGCGG 
                   
                 CUGCAC 
               
               
                   
                   
                   
                 CACCCCUGUGGUGG 
                   
                 CCGUAC 
               
               
                   
                   
                   
                 CCUGCGCCGUGAGC 
                   
                 CCCCGU 
               
               
                   
                   
                   
                 AAGCAGAGCAUCUG 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 GGCCCCUAGCUUCA 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 AGGAGCUGCUGGAC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 CAGGCCAGAUACUU 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CUACAGCACCGGCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 AGAGCGUGAGAAUC 
                   
                   
               
               
                   
                   
                   
                 CACGUGCAGAAGAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUGGACCUACC 
                   
                   
               
               
                   
                   
                   
                 CUCUGUUCGUGAAC 
                   
                   
               
               
                   
                   
                   
                 ACCUUCAGCGCGAA 
                   
                   
               
               
                   
                   
                   
                 CGCCCUGGUGGGCC 
                   
                   
               
               
                   
                   
                   
                 UGAGCAGCUGCAGC 
                   
                   
               
               
                   
                   
                   
                 GCCACCCAGUGCUU 
                   
                   
               
               
                   
                   
                   
                 CGGCCCCAAG 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 121 
                 122 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 221 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 122, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_PltB_nI 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACACCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 gK_cHis 
                   PDTTG EWTGDNTNA 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 YYSDEVISELHVGQI 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 DTSPYFCIKTVKANG 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SGTPVVACAVSKQSI 
                 UGGCGAGUGGACCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 WAPSFKELLDQARYF 
                 GCGACAACACCAAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 YSTGQSVRIHVQKNI 
                 GCCUACUACAGCGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 WTYPLFVNTFSANAL 
                 CGAGGUGAUCUCCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 VGLSSCSATQCFGPK 
                 AGCUGCACGUGGGA 
                   
                 UCCCCC 
               
               
                   
                   
                 HHHHHH 
                 CAGAUCGACACCAG 
                   
                 CAGCCC 
               
               
                   
                   
                   
                 CCCUUACUUCUGCA 
                   
                 CUCCUC 
               
               
                   
                   
                   
                 UCAAGACCGUGAAG 
                   
                 CCCUUC 
               
               
                   
                   
                   
                 GCCAACGGCAGCGG 
                   
                 CUGCAC 
               
               
                   
                   
                   
                 CACCCCUGUGGUGG 
                   
                 CCGUAC 
               
               
                   
                   
                   
                 CCUGCGCCGUGAGC 
                   
                 CCCCGU 
               
               
                   
                   
                   
                 AAGCAGAGCAUCUG 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 GGCCCCUAGCUUCA 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 AGGAGCUGCUGGAC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 CAGGCCAGAUACUU 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CUACAGCACCGGCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 AGAGCGUGAGAAUC 
                   
                   
               
               
                   
                   
                   
                 CACGUGCAGAAGAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUGGACCUACC 
                   
                   
               
               
                   
                   
                   
                 CUCUGUUCGUGAAC 
                   
                   
               
               
                   
                   
                   
                 ACCUUCAGCGCGAA 
                   
                   
               
               
                   
                   
                   
                 CGCCCUGGUGGGCC 
                   
                   
               
               
                   
                   
                   
                 UGAGCAGCUGCAGC 
                   
                   
               
               
                   
                   
                   
                 GCCACCCAGUGCUU 
                   
                   
               
               
                   
                   
                   
                 CGGCCCCAAGCACC 
                   
                   
               
               
                   
                   
                   
                 AUCACCACCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 123 
                 124 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 222 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 124, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_PltB 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACACCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 _NGM_nI 
                   PDTTG EWTGDNTNA 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 gK 
                 YYSDEVISELHVGQI 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 DTSPYFCIKTVKANG 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 AGTPVVACAVSKQSI 
                 UGGCGAGUGGACCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 WAPSFKELLDQARYF 
                 GCGACAACACCAAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 YSTGQSVRIHVQKNI 
                 GCCUACUACAGCGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 WTYPLFVNTFSANAL 
                 CGAGGUGAUCUCCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 VGLSSCSATQCFGPK 
                 AGCUGCACGUGGGA 
                   
                 UCCCCC 
               
               
                   
                   
                   
                 CAGAUCGACACCAG 
                   
                 CAGCCC 
               
               
                   
                   
                   
                 CCCUUACUUCUGCA 
                   
                 CUCCUC 
               
               
                   
                   
                   
                 UCAAGACCGUGAAG 
                   
                 CCCUUC 
               
               
                   
                   
                   
                 GCCAACGGCGCAGG 
                   
                 CUGCAC 
               
               
                   
                   
                   
                 CACCCCUGUGGUGG 
                   
                 CCGUAC 
               
               
                   
                   
                   
                 CCUGCGCCGUGAGC 
                   
                 CCCCGU 
               
               
                   
                   
                   
                 AAGCAGAGCAUCUG 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 GGCCCCUAGCUUCA 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 AGGAGCUGCUGGAC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 CAGGCCAGAUACUU 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CUACAGCACCGGCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 AGAGCGUGAGAAUC 
                   
                   
               
               
                   
                   
                   
                 CACGUGCAGAAGAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUGGACCUACC 
                   
                   
               
               
                   
                   
                   
                 CUCUGUUCGUGAAC 
                   
                   
               
               
                   
                   
                   
                 ACCUUCAGCGCGAA 
                   
                   
               
               
                   
                   
                   
                 CGCCCUGGUGGGCC 
                   
                   
               
               
                   
                   
                   
                 UGAGCAGCUGCAGC 
                   
                   
               
               
                   
                   
                   
                 GCCACCCAGUGCUU 
                   
                   
               
               
                   
                   
                   
                 CGGCCCCAAG 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 125 
                 126 
                 3 
                 4 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 223 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 126, and 3′ UTR SEQ ID NO: 4. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_PltB 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACACCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 _NGM_nI 
                   PDTTG EWTGDNTNA 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 gK_cHis 
                 YYSDEVISELHVGQI 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 DTSPYFCIKTVKANG 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 AGTPVVACAVSKQSI 
                 UGGCGAGUGGACCG 
                 UAAGAA 
                 GCCAUG 
               
               
                   
                   
                 WAPSFKELLDQARYF 
                 GCGACAACACCAAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 YSTGQSVRIHVQKNI 
                 GCCUACUACAGCGA 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 WTYPLFVNTFSANAL 
                 CGAGGUGAUCUCCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 VGLSSCSATQCFGPK 
                 AGCUGCACGUGGGA 
                   
                 UCCCCC 
               
               
                   
                   
                 HHHHHH 
                 CAGAUCGACACCAG 
                   
                 CAGCCC 
               
               
                   
                   
                   
                 CCCUUACUUCUGCA 
                   
                 CUCCUC 
               
               
                   
                   
                   
                 UCAAGACCGUGAAG 
                   
                 CCCUUC 
               
               
                   
                   
                   
                 GCCAACGGCGCAGG 
                   
                 CUGCAC 
               
               
                   
                   
                   
                 CACCCCUGUGGUGG 
                   
                 CCGUAC 
               
               
                   
                   
                   
                 CCUGCGCCGUGAGC 
                   
                 CCCCGU 
               
               
                   
                   
                   
                 AAGCAGAGCAUCUG 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 GGCCCCUAGCUUCA 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 AGGAGCUGCUGGAC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 CAGGCCAGAUACUU 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CUACAGCACCGGCC 
                   
                 GCGGC 
               
               
                   
                   
                   
                 AGAGCGUGAGAAUC 
                   
                   
               
               
                   
                   
                   
                 CACGUGCAGAAGAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUGGACCUACC 
                   
                   
               
               
                   
                   
                   
                 CUCUGUUCGUGAAC 
                   
                   
               
               
                   
                   
                   
                 ACCUUCAGCGCGAA 
                   
                   
               
               
                   
                   
                   
                 CGCCCUGGUGGGCC 
                   
                   
               
               
                   
                   
                   
                 UGAGCAGCUGCAGC 
                   
                   
               
               
                   
                   
                   
                 GCCACCCAGUGCUU 
                   
                   
               
               
                   
                   
                   
                 CGGCCCCAAGCACC 
                   
                   
               
               
                   
                   
                   
                 AUCACCACCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 127 
                 128 
                 3 
                 129 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 224 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 128, and 3′ UTR SEQ ID NO: 129. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_pilL_nI 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAAACCCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 gk 
                   PDTTG MNTQALFCLS 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 LPLVIAGCAQQTSTQ 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 TARDSAFAQSQQPSV 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 FSDIYQRSPEVTRSGR 
                 CGGCAUGAACACCC 
                 UAAGAA 
                 GCCUAG 
               
               
                   
                   
                 YTLVSIKSADAQREP 
                 AGGCCCUGUUCUGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 LNQLIDITMPGQLVN 
                 CUGAGCCUGCCUCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 SVGDGFRYLLFQSGY 
                 CGUCAUCGCCGGUU 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 SLCGHYGADFSELLN 
                 GCGCCCAGCAGACC 
                   
                 UCCCCC 
               
               
                   
                   
                 RPLPAVQRKIGPMRL 
                 AGCACCCAGACCGC 
                   
                 CAGCCC 
               
               
                   
                   
                 SEALQVVAGPAWRM 
                 CAGAGACAGCGCCU 
                   
                 CUCCUC 
               
               
                   
                   
                 SVDEVNREVCFVLRD 
                 UCGCCCAGAGCCAG 
                   
                 CCCUUC 
               
               
                   
                   
                 AYRVQAKTKALTSV 
                 CAGCCUAGCGUGUU 
                   
                 CUGCAC 
               
               
                   
                   
                 TPAVTGAARTSSPET 
                 CAGCGACAUCUACC 
                   
                 CCGUAC 
               
               
                   
                   
                 TRNPYTGVLPGNKAE 
                 AGAGAAGCCCUGAG 
                   
                 CCCCGU 
               
               
                   
                   
                 PVIAGQYLAVKKGTE 
                 GUGACCAGAAGCGG 
                   
                 GGUCUU 
               
               
                   
                   
                 LKPVSQSLPVPALRP 
                 CAGAUACACCCUGG 
                   
                 UGAAUA 
               
               
                   
                   
                 GGTPVTSGVSSAPPV 
                 UGAGCAUCAAGAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 KQVSSPAPRNPFTGK 
                 GCCGACGCCCAGAG 
                   
                 GAGUGG 
               
               
                   
                   
                 NLTGTTLSASHSPAP 
                 AGAGCCUCUGAACC 
                   
                 GCGGC 
               
               
                   
                   
                 VGEKAQAKTPSPSTV 
                 AGCUGAUCGACAUC 
                   
                   
               
               
                   
                   
                 KAVNPATATVLATTT 
                 ACCAUGCCUGGCCA 
                   
                   
               
               
                   
                   
                 KPLTGTPVAAVASGP 
                 GCUGGUGAACAGCG 
                   
                   
               
               
                   
                   
                 EWKAVVGSTLKESLT 
                 UGGGCGACGGCUUC 
                   
                   
               
               
                   
                   
                 DWAGRADCPGGGH 
                 AGAUACCUGCUGUU 
                   
                   
               
               
                   
                   
                 WVVIWQTPTDYRIDA 
                 CCAGAGCGGCUACA 
                   
                   
               
               
                   
                   
                 PLVFKGNFETALVQV 
                 GCCUGUGCGGCCAC 
                   
                   
               
               
                   
                   
                 FDLYKKADKPLFAEA 
                 UACGGAGCCGACUU 
                   
                   
               
               
                   
                   
                 SRLQCLVSVADKPAD 
                 CAGCGAGCUGCUGA 
                   
                   
               
               
                   
                   
                 RS 
                 ACAGACCUCUGCCU 
                   
                   
               
               
                   
                   
                   
                 GCCGUGCAGAGAAA 
                   
                   
               
               
                   
                   
                   
                 GAUCGGCCCUAUGA 
                   
                   
               
               
                   
                   
                   
                 GACUGAGCGAAGCC 
                   
                   
               
               
                   
                   
                   
                 CUGCAGGUGGUCGC 
                   
                   
               
               
                   
                   
                   
                 GGGCCCUGCCUGGA 
                   
                   
               
               
                   
                   
                   
                 GAAUGAGCGUGGAC 
                   
                   
               
               
                   
                   
                   
                 GAGGUGAACAGAGA 
                   
                   
               
               
                   
                   
                   
                 GGUGUGCUUCGUGC 
                   
                   
               
               
                   
                   
                   
                 UGAGAGACGCCUAC 
                   
                   
               
               
                   
                   
                   
                 AGAGUGCAGGCCAA 
                   
                   
               
               
                   
                   
                   
                 GACCAAGGCCCUGA 
                   
                   
               
               
                   
                   
                   
                 CCAGCGUGACUCCA 
                   
                   
               
               
                   
                   
                   
                 GCCGUUACCGGCGC 
                   
                   
               
               
                   
                   
                   
                 CGCCCGGACAUCCU 
                   
                   
               
               
                   
                   
                   
                 CCCCUGAGACUACC 
                   
                   
               
               
                   
                   
                   
                 AGAAACCCUUACAC 
                   
                   
               
               
                   
                   
                   
                 CGGCGUGCUGCCUG 
                   
                   
               
               
                   
                   
                   
                 GCAACAAGGCCGAG 
                   
                   
               
               
                   
                   
                   
                 CCCGUGAUCGCCGG 
                   
                   
               
               
                   
                   
                   
                 CCAGUACCUGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGAAGAAGGGCACC 
                   
                   
               
               
                   
                   
                   
                 GAGCUGAAGCCUGU 
                   
                   
               
               
                   
                   
                   
                 GAGCCAGAGCCUGC 
                   
                   
               
               
                   
                   
                   
                 CUGUGCCUGCCCUG 
                   
                   
               
               
                   
                   
                   
                 AGGCCUGGCGGCAC 
                   
                   
               
               
                   
                   
                   
                 CCCUGUGACCUCGG 
                   
                   
               
               
                   
                   
                   
                 GCGUGUCCUCUGCC 
                   
                   
               
               
                   
                   
                   
                 CCUCCUGUGAAGCA 
                   
                   
               
               
                   
                   
                   
                 GGUGAGCAGCCCCG 
                   
                   
               
               
                   
                   
                   
                 CCCCUAGAAACCCU 
                   
                   
               
               
                   
                   
                   
                 UUCACCGGCAAGAA 
                   
                   
               
               
                   
                   
                   
                 CCUGACCGGCACCA 
                   
                   
               
               
                   
                   
                   
                 CCCUGAGCGCCAGC 
                   
                   
               
               
                   
                   
                   
                 CACAGUCCCGCUCC 
                   
                   
               
               
                   
                   
                   
                 GGUGGGCGAGAAGG 
                   
                   
               
               
                   
                   
                   
                 CCCAGGCAAAGACG 
                   
                   
               
               
                   
                   
                   
                 CCUAGCCCUAGCAC 
                   
                   
               
               
                   
                   
                   
                 CGUGAAGGCCGUGA 
                   
                   
               
               
                   
                   
                   
                 ACCCUGCCACCGCC 
                   
                   
               
               
                   
                   
                   
                 ACCGUGCUCGCCAC 
                   
                   
               
               
                   
                   
                   
                 CACCACUAAGCCUC 
                   
                   
               
               
                   
                   
                   
                 UGACCGGAACUCCC 
                   
                   
               
               
                   
                   
                   
                 GUGGCCGCCGUAGC 
                   
                   
               
               
                   
                   
                   
                 CAGCGGACCUGAGU 
                   
                   
               
               
                   
                   
                   
                 GGAAAGCUGUCGUG 
                   
                   
               
               
                   
                   
                   
                 GGCUCGACCCUGAA 
                   
                   
               
               
                   
                   
                   
                 GGAGAGCCUGACCG 
                   
                   
               
               
                   
                   
                   
                 ACUGGGCCGGCAGA 
                   
                   
               
               
                   
                   
                   
                 GCCGAUUGCCCCGG 
                   
                   
               
               
                   
                   
                   
                 CGGCGGGCACUGGG 
                   
                   
               
               
                   
                   
                   
                 UGGUGAUCUGGCAG 
                   
                   
               
               
                   
                   
                   
                 ACCCCUACCGACUA 
                   
                   
               
               
                   
                   
                   
                 CAGAAUCGACGCCC 
                   
                   
               
               
                   
                   
                   
                 CUCUGGUGUUCAAG 
                   
                   
               
               
                   
                   
                   
                 GGCAACUUCGAGAC 
                   
                   
               
               
                   
                   
                   
                 AGCCCUGGUGCAGG 
                   
                   
               
               
                   
                   
                   
                 UGUUCGACCUGUAC 
                   
                   
               
               
                   
                   
                   
                 AAGAAGGCCGACAA 
                   
                   
               
               
                   
                   
                   
                 GCCCCUGUUCGCCG 
                   
                   
               
               
                   
                   
                   
                 AGGCCAGCAGACUG 
                   
                   
               
               
                   
                   
                   
                 CAGUGCCUGGUGUC 
                   
                   
               
               
                   
                   
                   
                 CGUGGCCGACAAAC 
                   
                   
               
               
                   
                   
                   
                 CCGCCGACAGAAGC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 130 
                 131 
                 3 
                 129 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 225 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 131, and 3′ UTR SEQ ID NO: 129. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_pilL_N 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAAACCCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 GM_nIgk 
                   PDTTG MNTQALFCLS 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                   
                 LPLVIAGCAQQTSTQ 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 TARDSAFAQSQQPSV 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 FSDIYQRSPEVTRSGR 
                 CGGCAUGAACACCC 
                 UAAGAA 
                 GCCUAG 
               
               
                   
                   
                 YTLVSIKSADAQREP 
                 AGGCCCUGUUCUGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 LNQLIDITMPGQLVN 
                 CUGAGCCUGCCUCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 SVGDGFRYLLFQSGY 
                 CGUCAUCGCCGGUU 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 SLCGHYGADFSELLN 
                 GCGCCCAGCAGACC 
                   
                 UCCCCC 
               
               
                   
                   
                 RPLPAVQRKIGPMRL 
                 AGCACCCAGACCGC 
                   
                 CAGCCC 
               
               
                   
                   
                 SEALQVVAGPAWRM 
                 CAGAGACAGCGCCU 
                   
                 CUCCUC 
               
               
                   
                   
                 SVDEVNREVCFVLRD 
                 UCGCCCAGAGCCAG 
                   
                 CCCUUC 
               
               
                   
                   
                 AYRVQAKTKALTSV 
                 CAGCCUAGCGUGUU 
                   
                 CUGCAC 
               
               
                   
                   
                 TPAVTGAARTSSPET 
                 CAGCGACAUCUACC 
                   
                 CCGUAC 
               
               
                   
                   
                 TRNPYTGVLPGNKAE 
                 AGAGAAGCCCUGAG 
                   
                 CCCCGU 
               
               
                   
                   
                 PVIAGQYLAVKKGTE 
                 GUGACCAGAAGCGG 
                   
                 GGUCUU 
               
               
                   
                   
                 LKPVSQSLPVPALRP 
                 CAGAUACACCCUGG 
                   
                 UGAAUA 
               
               
                   
                   
                 GGTPVTSGVSSAPPV 
                 UGAGCAUCAAGAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 KQVSSPAPRNPFTGK 
                 GCCGACGCCCAGAG 
                   
                 GAGUGG 
               
               
                   
                   
                 NLAGTTLSASHSPAP 
                 AGAGCCUCUGAACC 
                   
                 GCGGC 
               
               
                   
                   
                 VGEKAQAKTPSPSTV 
                 AGCUGAUCGACAUC 
                   
                   
               
               
                   
                   
                 KAVNPATATVLATTT 
                 ACCAUGCCUGGCCA 
                   
                   
               
               
                   
                   
                 KPLTGTPVAAVASGP 
                 GCUGGUGAACAGCG 
                   
                   
               
               
                   
                   
                 EWKAVVGSTLKESLT 
                 UGGGCGACGGCUUC 
                   
                   
               
               
                   
                   
                 DWAGRADCPGGGH 
                 AGAUACCUGCUGUU 
                   
                   
               
               
                   
                   
                 WVVIWQTPTDYRIDA 
                 CCAGAGCGGCUACA 
                   
                   
               
               
                   
                   
                 PLVFKGNFETALVQV 
                 GCCUGUGCGGCCAC 
                   
                   
               
               
                   
                   
                 FDLYKKADKPLFAEA 
                 UACGGAGCCGACUU 
                   
                   
               
               
                   
                   
                 SRLQCLVSVADKPAD 
                 CAGCGAGCUGCUGA 
                   
                   
               
               
                   
                   
                 RS 
                 ACAGACCUCUGCCU 
                   
                   
               
               
                   
                   
                   
                 GCCGUGCAGAGAAA 
                   
                   
               
               
                   
                   
                   
                 GAUCGGCCCUAUGA 
                   
                   
               
               
                   
                   
                   
                 GACUGAGCGAAGCC 
                   
                   
               
               
                   
                   
                   
                 CUGCAGGUGGUCGC 
                   
                   
               
               
                   
                   
                   
                 GGGCCCUGCCUGGA 
                   
                   
               
               
                   
                   
                   
                 GAAUGAGCGUGGAC 
                   
                   
               
               
                   
                   
                   
                 GAGGUGAACAGAGA 
                   
                   
               
               
                   
                   
                   
                 GGUGUGCUUCGUGC 
                   
                   
               
               
                   
                   
                   
                 UGAGAGACGCCUAC 
                   
                   
               
               
                   
                   
                   
                 AGAGUGCAGGCCAA 
                   
                   
               
               
                   
                   
                   
                 GACCAAGGCCCUGA 
                   
                   
               
               
                   
                   
                   
                 CCAGCGUGACUCCA 
                   
                   
               
               
                   
                   
                   
                 GCCGUUACCGGCGC 
                   
                   
               
               
                   
                   
                   
                 CGCCCGGACAUCCU 
                   
                   
               
               
                   
                   
                   
                 CCCCUGAGACUACC 
                   
                   
               
               
                   
                   
                   
                 AGAAACCCUUACAC 
                   
                   
               
               
                   
                   
                   
                 CGGCGUGCUGCCUG 
                   
                   
               
               
                   
                   
                   
                 GCAACAAGGCCGAG 
                   
                   
               
               
                   
                   
                   
                 CCCGUGAUCGCCGG 
                   
                   
               
               
                   
                   
                   
                 CCAGUACCUGGCCG 
                   
                   
               
               
                   
                   
                   
                 UGAAGAAGGGCACC 
                   
                   
               
               
                   
                   
                   
                 GAGCUGAAGCCUGU 
                   
                   
               
               
                   
                   
                   
                 GAGCCAGAGCCUGC 
                   
                   
               
               
                   
                   
                   
                 CUGUGCCUGCCCUG 
                   
                   
               
               
                   
                   
                   
                 AGGCCUGGCGGCAC 
                   
                   
               
               
                   
                   
                   
                 CCCUGUGACCUCGG 
                   
                   
               
               
                   
                   
                   
                 GCGUGUCCUCUGCC 
                   
                   
               
               
                   
                   
                   
                 CCUCCUGUGAAGCA 
                   
                   
               
               
                   
                   
                   
                 GGUGAGCAGCCCCG 
                   
                   
               
               
                   
                   
                   
                 CCCCUAGAAACCCU 
                   
                   
               
               
                   
                   
                   
                 UUCACCGGCAAGAA 
                   
                   
               
               
                   
                   
                   
                 CCUGGCCGGCACCA 
                   
                   
               
               
                   
                   
                   
                 CCCUGAGCGCCAGC 
                   
                   
               
               
                   
                   
                   
                 CACAGUCCCGCUCC 
                   
                   
               
               
                   
                   
                   
                 GGUGGGCGAGAAGG 
                   
                   
               
               
                   
                   
                   
                 CCCAGGCAAAGACG 
                   
                   
               
               
                   
                   
                   
                 CCUAGCCCUAGCAC 
                   
                   
               
               
                   
                   
                   
                 CGUGAAGGCCGUGA 
                   
                   
               
               
                   
                   
                   
                 ACCCUGCCACCGCC 
                   
                   
               
               
                   
                   
                   
                 ACCGUGCUCGCCAC 
                   
                   
               
               
                   
                   
                   
                 CACCACUAAGCCUC 
                   
                   
               
               
                   
                   
                   
                 UGACCGGAACUCCC 
                   
                   
               
               
                   
                   
                   
                 GUGGCCGCCGUAGC 
                   
                   
               
               
                   
                   
                   
                 CAGCGGACCUGAGU 
                   
                   
               
               
                   
                   
                   
                 GGAAAGCUGUCGUG 
                   
                   
               
               
                   
                   
                   
                 GGCUCGACCCUGAA 
                   
                   
               
               
                   
                   
                   
                 GGAGAGCCUGACCG 
                   
                   
               
               
                   
                   
                   
                 ACUGGGCCGGCAGA 
                   
                   
               
               
                   
                   
                   
                 GCCGAUUGCCCCGG 
                   
                   
               
               
                   
                   
                   
                 CGGCGGGCACUGGG 
                   
                   
               
               
                   
                   
                   
                 UGGUGAUCUGGCAG 
                   
                   
               
               
                   
                   
                   
                 ACCCCUACCGACUA 
                   
                   
               
               
                   
                   
                   
                 CAGAAUCGACGCCC 
                   
                   
               
               
                   
                   
                   
                 CUCUGGUGUUCAAG 
                   
                   
               
               
                   
                   
                   
                 GGCAACUUCGAGAC 
                   
                   
               
               
                   
                   
                   
                 AGCCCUGGUGCAGG 
                   
                   
               
               
                   
                   
                   
                 UGUUCGACCUGUAC 
                   
                   
               
               
                   
                   
                   
                 AAGAAGGCCGACAA 
                   
                   
               
               
                   
                   
                   
                 GCCCCUGUUCGCCG 
                   
                   
               
               
                   
                   
                   
                 AGGCCAGCAGACUG 
                   
                   
               
               
                   
                   
                   
                 CAGUGCCUGGUGUC 
                   
                   
               
               
                   
                   
                   
                 CGUGGCCGACAAAC 
                   
                   
               
               
                   
                   
                   
                 CCGCCGACAGAAGC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 132 
                 133 
                 3 
                 129 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 226 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 133, and 3′ UTR SEQ ID NO: 129. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_T0937_ 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACUCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK_NG 
                   PDTTG QTTNRSTAKD 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 M_cHis 
                 EILTGSYIDPTKTRFP 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 LADYSQSVDKWIPPD 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SADYTIPVIDSATQQR 
                 CGGCCAGACCACCA 
                 UAAGAA 
                 GCCUAG 
               
               
                   
                   
                 YFSALKSHYFGMDSE 
                 ACAGAAGCACCGCC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 AHSPWNDFYITALLK 
                 AAGGACGAGAUCCU 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 KNAAQARDASIKQFL 
                 GACCGGCAGCUACA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 SDGSAYWGENFRLY 
                 UCGACCCUACCAAG 
                   
                 UCCCCC 
               
               
                   
                   
                 TSRWKEEVRGNTDT 
                 ACCAGAUUUCCCCU 
                   
                 CAGCCC 
               
               
                   
                   
                 QIDNIYHASRRGIMV 
                 GGCUGAUUAUAGCC 
                   
                 CUCCUC 
               
               
                   
                   
                 RESLVRALPTDDPLF 
                 AGAGCGUGGACAAG 
                   
                 CCCUUC 
               
               
                   
                   
                 NDPRQAGEGYPFDNL 
                 UGGAUCCCUCCUGA 
                   
                 CUGCAC 
               
               
                   
                   
                 QMSSLRPGTPVYTLT 
                 CUCAGCCGACUACA 
                   
                 CCGUAC 
               
               
                   
                   
                 KSKDQRWQYVVSPA 
                 CCAUCCCUGUGAUC 
                   
                 CCCCGU 
               
               
                   
                   
                 VTGWVHSEDIASTDQ 
                 GACAGCGCCACCCA 
                   
                 GGUCUU 
               
               
                   
                   
                 KFITQWVLLAHKQLG 
                 GCAGAGAUACUUCA 
                   
                 UGAAUA 
               
               
                   
                   
                 AFINAPVSVHAAGVY 
                 GCGCCCUGAAGUCC 
                   
                 AAGUCU 
               
               
                   
                   
                 YFTGRPGTILPFRHQR 
                 CACUACUUCGGCAU 
                   
                 GAGUGG 
               
               
                   
                   
                 AGQFLIAAPVRGSNG 
                 GGACAGCGAGGCCC 
                   
                 GCGGC 
               
               
                   
                   
                 RAFIHWVWLSGNEFT 
                 ACAGCCCUUGGAAC 
                   
                   
               
               
                   
                   
                 AMPWKMTPENIAVL 
                 GACUUCUACAUCAC 
                   
                   
               
               
                   
                   
                 MKAMHGAPYGWGN 
                 CGCCCUGCUGAAGA 
                   
                   
               
               
                   
                   
                 FNFYNDCSAEVRSLL 
                 AGAACGCCGCCCAG 
                   
                   
               
               
                   
                   
                 MPFGIFLPRHSSAQVE 
                 GCCAGAGACGCCAG 
                   
                   
               
               
                   
                   
                 SAGRVVDLSHKNPQ 
                 CAUCAAGCAGUUUC 
                   
                   
               
               
                   
                   
                 MRIDYLTRYGKAFTT 
                 UGUCCGACGGCAGC 
                   
                   
               
               
                   
                   
                 LVYIPGHIMLYIGNTA 
                 GCCUACUGGGGCGA 
                   
                   
               
               
                   
                   
                 MNGQVVPMTYQNIW 
                 GAACUUCAGACUGU 
                   
                   
               
               
                   
                   
                 GLRPNHANSRSIIGEA 
                 ACACCAGCCGGUGG 
                   
                   
               
               
                   
                   
                 VFLPLLRFYPENPELI 
                 AAGGAGGAGGUGA 
                   
                   
               
               
                   
                   
                 SLAGKVLFKLGYIEH 
                 GAGGCAACACCGAC 
                   
                   
               
               
                   
                   
                 HHHHH 
                 ACCCAGAUCGACAA 
                   
                   
               
               
                   
                   
                   
                 CAUCUACCACGCCA 
                   
                   
               
               
                   
                   
                   
                 GCCGAAGGGGCAUC 
                   
                   
               
               
                   
                   
                   
                 AUGGUGAGAGAGA 
                   
                   
               
               
                   
                   
                   
                 GCCUGGUGAGAGCC 
                   
                   
               
               
                   
                   
                   
                 CUGCCUACCGACGA 
                   
                   
               
               
                   
                   
                   
                 CCCUCUGUUCAACG 
                   
                   
               
               
                   
                   
                   
                 ACCCUAGACAGGCC 
                   
                   
               
               
                   
                   
                   
                 GGCGAGGGCUACCC 
                   
                   
               
               
                   
                   
                   
                 UUUCGACAACCUGC 
                   
                   
               
               
                   
                   
                   
                 AGAUGAGCAGCCUG 
                   
                   
               
               
                   
                   
                   
                 CGCCCUGGCACCCC 
                   
                   
               
               
                   
                   
                   
                 UGUGUACACCCUGA 
                   
                   
               
               
                   
                   
                   
                 CCAAGAGCAAGGAC 
                   
                   
               
               
                   
                   
                   
                 CAGCGGUGGCAGUA 
                   
                   
               
               
                   
                   
                   
                 CGUGGUGUCCCCUG 
                   
                   
               
               
                   
                   
                   
                 CCGUGACAGGGUGG 
                   
                   
               
               
                   
                   
                   
                 GUGCACAGCGAGGA 
                   
                   
               
               
                   
                   
                   
                 CAUCGCCAGCACCG 
                   
                   
               
               
                   
                   
                   
                 ACCAGAAGUUCAUC 
                   
                   
               
               
                   
                   
                   
                 ACCCAGUGGGUGCU 
                   
                   
               
               
                   
                   
                   
                 GCUGGCCCAUAAGC 
                   
                   
               
               
                   
                   
                   
                 AGCUCGGCGCCUUC 
                   
                   
               
               
                   
                   
                   
                 AUCAACGCCCCUGU 
                   
                   
               
               
                   
                   
                   
                 UUCCGUGCACGCCG 
                   
                   
               
               
                   
                   
                   
                 CCGGCGUGUACUAC 
                   
                   
               
               
                   
                   
                   
                 UUCACCGGCAGACC 
                   
                   
               
               
                   
                   
                   
                 CGGAACCAUCCUGC 
                   
                   
               
               
                   
                   
                   
                 CUUUCAGACACCAG 
                   
                   
               
               
                   
                   
                   
                 AGAGCCGGGCAGUU 
                   
                   
               
               
                   
                   
                   
                 CCUGAUAGCCGCCC 
                   
                   
               
               
                   
                   
                   
                 CGGUACGCGGGAGC 
                   
                   
               
               
                   
                   
                   
                 AACGGCCGGGCCUU 
                   
                   
               
               
                   
                   
                   
                 UAUCCACUGGGUGU 
                   
                   
               
               
                   
                   
                   
                 GGCUGAGCGGCAAC 
                   
                   
               
               
                   
                   
                   
                 GAGUUCACCGCCAU 
                   
                   
               
               
                   
                   
                   
                 GCCUUGGAAGAUGA 
                   
                   
               
               
                   
                   
                   
                 CCCCUGAGAACAUC 
                   
                   
               
               
                   
                   
                   
                 GCCGUCCUGAUGAA 
                   
                   
               
               
                   
                   
                   
                 GGCCAUGCACGGCG 
                   
                   
               
               
                   
                   
                   
                 CCCCUUACGGCUGG 
                   
                   
               
               
                   
                   
                   
                 GGCAACUUCAACUU 
                   
                   
               
               
                   
                   
                   
                 CUACAACGACUGCA 
                   
                   
               
               
                   
                   
                   
                 GCGCCGAGGUGAGA 
                   
                   
               
               
                   
                   
                   
                 AGCCUGCUGAUGCC 
                   
                   
               
               
                   
                   
                   
                 UUUCGGCAUCUUCC 
                   
                   
               
               
                   
                   
                   
                 UGCCCCGUCACUCC 
                   
                   
               
               
                   
                   
                   
                 AGCGCCCAGGUCGA 
                   
                   
               
               
                   
                   
                   
                 GAGCGCCGGCAGAG 
                   
                   
               
               
                   
                   
                   
                 UGGUGGACCUGAGC 
                   
                   
               
               
                   
                   
                   
                 CACAAGAACCCUCA 
                   
                   
               
               
                   
                   
                   
                 GAUGAGAAUCGACU 
                   
                   
               
               
                   
                   
                   
                 ACCUGACCAGAUAC 
                   
                   
               
               
                   
                   
                   
                 GGCAAGGCCUUCAC 
                   
                   
               
               
                   
                   
                   
                 CACACUCGUGUACA 
                   
                   
               
               
                   
                   
                   
                 UCCCCGGCCACAUC 
                   
                   
               
               
                   
                   
                   
                 AUGCUGUACAUCGG 
                   
                   
               
               
                   
                   
                   
                 CAACACAGCCAUGA 
                   
                   
               
               
                   
                   
                   
                 ACGGCCAGGUGGUG 
                   
                   
               
               
                   
                   
                   
                 CCUAUGACCUACCA 
                   
                   
               
               
                   
                   
                   
                 GAACAUCUGGGGCC 
                   
                   
               
               
                   
                   
                   
                 UCAGACCUAACCAC 
                   
                   
               
               
                   
                   
                   
                 GCCAACAGCAGAAG 
                   
                   
               
               
                   
                   
                   
                 CAUCAUCGGCGAGG 
                   
                   
               
               
                   
                   
                   
                 CCGUGUUCCUGCCU 
                   
                   
               
               
                   
                   
                   
                 CUGCUGAGAUUCUA 
                   
                   
               
               
                   
                   
                   
                 CCCUGAGAACCCUG 
                   
                   
               
               
                   
                   
                   
                 AGCUGAUCAGCCUG 
                   
                   
               
               
                   
                   
                   
                 GCCGGCAAGGUGCU 
                   
                   
               
               
                   
                   
                   
                 GUUCAAGCUGGGCU 
                   
                   
               
               
                   
                   
                   
                 ACAUCGAGCACCAU 
                   
                   
               
               
                   
                   
                   
                 CACCACCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 134 
                 135 
                 3 
                 129 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 227 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 135, and 3′ UTR SEQ ID NO: 129. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_T0937_ 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACUCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 nIgK_nTru 
                   PDTTG VDKWIPPDSA 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 nc_NGM_ 
                 DYTIPVIDSATQQRYF 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                 cHis 
                 SALKSHYFGMDSEA 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 HSPWNDFYITALLKK 
                 CGGCGUGGACAAGU 
                 UAAGAA 
                 GCCUAG 
               
               
                   
                   
                 NAAQARDASIKQFLS 
                 GGAUCCCUCCUGAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 DGSAYWGENFRLYT 
                 UCAGCCGACUACAC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 SRWKEEVRGNTDTQI 
                 CAUCCCUGUGAUCG 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 DNIYHASRRGIMVRE 
                 ACAGCGCCACCCAG 
                   
                 UCCCCC 
               
               
                   
                   
                 SLVRALPTDDPLFND 
                 CAGAGAUACUUCAG 
                   
                 CAGCCC 
               
               
                   
                   
                 PRQAGEGYPFDNLQ 
                 CGCCCUGAAGUCCC 
                   
                 CUCCUC 
               
               
                   
                   
                 MSSLRPGTPVYTLTK 
                 ACUACUUCGGCAUG 
                   
                 CCCUUC 
               
               
                   
                   
                 SKDQRWQYVVSPAV 
                 GACAGCGAGGCCCA 
                   
                 CUGCAC 
               
               
                   
                   
                 TGWVHSEDIASTDQK 
                 CAGCCCUUGGAACG 
                   
                 CCGUAC 
               
               
                   
                   
                 FITQWVLLAHKQLGA 
                 ACUUCUACAUCACC 
                   
                 CCCCGU 
               
               
                   
                   
                 FINAPVSVHAAGVYY 
                 GCCCUGCUGAAGAA 
                   
                 GGUCUU 
               
               
                   
                   
                 FTGRPGTILPFRHQRA 
                 GAACGCCGCCCAGG 
                   
                 UGAAUA 
               
               
                   
                   
                 GQFLIAAPVRGSNGR 
                 CCAGAGACGCCAGC 
                   
                 AAGUCU 
               
               
                   
                   
                 AFIHWVWLSGNEFTA 
                 AUCAAGCAGUUUCU 
                   
                 GAGUGG 
               
               
                   
                   
                 MPWKMTPENIAVLM 
                 GUCCGACGGCAGCG 
                   
                 GCGGC 
               
               
                   
                   
                 KAMHGAPYGWGNF 
                 CCUACUGGGGCGAG 
                   
                   
               
               
                   
                   
                 NFYNDCSAEVRSLLM 
                 AACUUCAGACUGUA 
                   
                   
               
               
                   
                   
                 PFGIFLPRHSSAQVES 
                 CACCAGCCGGUGGA 
                   
                   
               
               
                   
                   
                 AGRVVDLSHKNPQM 
                 AGGAGGAGGUGAG 
                   
                   
               
               
                   
                   
                 RIDYLTRYGKAFTTL 
                 AGGCAACACCGACA 
                   
                   
               
               
                   
                   
                 VYIPGHIMLYIGNTA 
                 CCCAGAUCGACAAC 
                   
                   
               
               
                   
                   
                 MNGQVVPMTYQNIW 
                 AUCUACCACGCCAG 
                   
                   
               
               
                   
                   
                 GLRPNHANSRSIIGEA 
                 CCGAAGGGGCAUCA 
                   
                   
               
               
                   
                   
                 VFLPLLRFYPENPELI 
                 UGGUGAGAGAGAGC 
                   
                   
               
               
                   
                   
                 SLAGKVLFKLGYIEH 
                 CUGGUGAGAGCCCU 
                   
                   
               
               
                   
                   
                 HHHHH 
                 GCCUACCGACGACC 
                   
                   
               
               
                   
                   
                   
                 CUCUGUUCAACGAC 
                   
                   
               
               
                   
                   
                   
                 CCUAGACAGGCCGG 
                   
                   
               
               
                   
                   
                   
                 CGAGGGCUACCCUU 
                   
                   
               
               
                   
                   
                   
                 UCGACAACCUGCAG 
                   
                   
               
               
                   
                   
                   
                 AUGAGCAGCCUGCG 
                   
                   
               
               
                   
                   
                   
                 CCCUGGCACCCCUG 
                   
                   
               
               
                   
                   
                   
                 UGUACACCCUGACC 
                   
                   
               
               
                   
                   
                   
                 AAGAGCAAGGACCA 
                   
                   
               
               
                   
                   
                   
                 GCGGUGGCAGUACG 
                   
                   
               
               
                   
                   
                   
                 UGGUGUCCCCUGCC 
                   
                   
               
               
                   
                   
                   
                 GUGACAGGGUGGGU 
                   
                   
               
               
                   
                   
                   
                 GCACAGCGAGGACA 
                   
                   
               
               
                   
                   
                   
                 UCGCCAGCACCGAC 
                   
                   
               
               
                   
                   
                   
                 CAGAAGUUCAUCAC 
                   
                   
               
               
                   
                   
                   
                 CCAGUGGGUGCUGC 
                   
                   
               
               
                   
                   
                   
                 UGGCCCAUAAGCAG 
                   
                   
               
               
                   
                   
                   
                 CUCGGCGCCUUCAU 
                   
                   
               
               
                   
                   
                   
                 CAACGCCCCUGUUU 
                   
                   
               
               
                   
                   
                   
                 CCGUGCACGCCGCC 
                   
                   
               
               
                   
                   
                   
                 GGCGUGUACUACUU 
                   
                   
               
               
                   
                   
                   
                 CACCGGCAGACCCG 
                   
                   
               
               
                   
                   
                   
                 GAACCAUCCUGCCU 
                   
                   
               
               
                   
                   
                   
                 UUCAGACACCAGAG 
                   
                   
               
               
                   
                   
                   
                 AGCCGGGCAGUUCC 
                   
                   
               
               
                   
                   
                   
                 UGAUAGCCGCCCCG 
                   
                   
               
               
                   
                   
                   
                 GUACGCGGGAGCAA 
                   
                   
               
               
                   
                   
                   
                 CGGCCGGGCCUUUA 
                   
                   
               
               
                   
                   
                   
                 UCCACUGGGUGUGG 
                   
                   
               
               
                   
                   
                   
                 CUGAGCGGCAACGA 
                   
                   
               
               
                   
                   
                   
                 GUUCACCGCCAUGC 
                   
                   
               
               
                   
                   
                   
                 CUUGGAAGAUGACC 
                   
                   
               
               
                   
                   
                   
                 CCUGAGAACAUCGC 
                   
                   
               
               
                   
                   
                   
                 CGUCCUGAUGAAGG 
                   
                   
               
               
                   
                   
                   
                 CCAUGCACGGCGCC 
                   
                   
               
               
                   
                   
                   
                 CCUUACGGCUGGGG 
                   
                   
               
               
                   
                   
                   
                 CAACUUCAACUUCU 
                   
                   
               
               
                   
                   
                   
                 ACAACGACUGCAGC 
                   
                   
               
               
                   
                   
                   
                 GCCGAGGUGAGAAG 
                   
                   
               
               
                   
                   
                   
                 CCUGCUGAUGCCUU 
                   
                   
               
               
                   
                   
                   
                 UCGGCAUCUUCCUG 
                   
                   
               
               
                   
                   
                   
                 CCCCGUCACUCCAG 
                   
                   
               
               
                   
                   
                   
                 CGCCCAGGUCGAGA 
                   
                   
               
               
                   
                   
                   
                 GCGCCGGCAGAGUG 
                   
                   
               
               
                   
                   
                   
                 GUGGACCUGAGCCA 
                   
                   
               
               
                   
                   
                   
                 CAAGAACCCUCAGA 
                   
                   
               
               
                   
                   
                   
                 UGAGAAUCGACUAC 
                   
                   
               
               
                   
                   
                   
                 CUGACCAGAUACGG 
                   
                   
               
               
                   
                   
                   
                 CAAGGCCUUCACCA 
                   
                   
               
               
                   
                   
                   
                 CACUCGUGUACAUC 
                   
                   
               
               
                   
                   
                   
                 CCCGGCCACAUCAU 
                   
                   
               
               
                   
                   
                   
                 GCUGUACAUCGGCA 
                   
                   
               
               
                   
                   
                   
                 ACACAGCCAUGAAC 
                   
                   
               
               
                   
                   
                   
                 GGCCAGGUGGUGCC 
                   
                   
               
               
                   
                   
                   
                 UAUGACCUACCAGA 
                   
                   
               
               
                   
                   
                   
                 ACAUCUGGGGCCUC 
                   
                   
               
               
                   
                   
                   
                 AGACCUAACCACGC 
                   
                   
               
               
                   
                   
                   
                 CAACAGCAGAAGCA 
                   
                   
               
               
                   
                   
                   
                 UCAUCGGCGAGGCC 
                   
                   
               
               
                   
                   
                   
                 GUGUUCCUGCCUCU 
                   
                   
               
               
                   
                   
                   
                 GCUGAGAUUCUACC 
                   
                   
               
               
                   
                   
                   
                 CUGAGAACCCUGAG 
                   
                   
               
               
                   
                   
                   
                 CUGAUCAGCCUGGC 
                   
                   
               
               
                   
                   
                   
                 CGGCAAGGUGCUGU 
                   
                   
               
               
                   
                   
                   
                 UCAAGCUGGGCUAC 
                   
                   
               
               
                   
                   
                   
                 AUCGAGCACCAUCA 
                   
                   
               
               
                   
                   
                   
                 CCACCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 136 
                 137 
                 3 
                 129 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 228 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 3, mRNA ORF SEQ ID NO: 137, and 3′ UTR SEQ ID NO: 129. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_slyB_nI 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAAACGCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 gK_NGM_ 
                   PDTTG DSLSGDVYTA 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 cHis 
                 SEAKQVQNVAYGTIV 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 NVRPVQIQGGDDSNV 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 IGAIGGAVLGGFLGN 
                 CGGCGACAGCCUGA 
                 UAAGAA 
                 GCCUAG 
               
               
                   
                   
                 TIGGGTGRSLATAAG 
                 GCGGCGACGUGUAC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 AVAGGVAGQGVQSA 
                 ACCGCCAGCGAGGC 
                 UAAGAG 
                 GCCCCU 
               
               
                   
                   
                 MNKAQGVELEIRKD 
                 CAAGCAGGUGCAGA 
                 CCACC 
                 UGGGCC 
               
               
                   
                   
                 DGNTIMVVQKQGNT 
                 ACGUGGCCUACGGC 
                   
                 UCCCCC 
               
               
                   
                   
                 RFSAGQRVVLASNG 
                 ACCAUCGUGAACGU 
                   
                 CAGCCC 
               
               
                   
                   
                 AQVTVSPRHHHHHH 
                 CAGACCUGUGCAGA 
                   
                 CUCCUC 
               
               
                   
                   
                   
                 UCCAGGGCGGGGAC 
                   
                 CCCUUC 
               
               
                   
                   
                   
                 GACAGCAACGUGAU 
                   
                 CUGCAC 
               
               
                   
                   
                   
                 CGGCGCCAUUGGAG 
                   
                 CCGUAC 
               
               
                   
                   
                   
                 GUGCCGUGCUGGGC 
                   
                 CCCCGU 
               
               
                   
                   
                   
                 GGCUUCCUGGGCAA 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 CACUAUCGGCGGCG 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 GCACCGGCAGAAGC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 CUGGCCACAGCCGC 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CGGAGCCGUGGCUG 
                   
                 GCGGC 
               
               
                   
                   
                   
                 GCGGCGUGGCCGGU 
                   
                   
               
               
                   
                   
                   
                 CAGGGAGUGCAGAG 
                   
                   
               
               
                   
                   
                   
                 CGCCAUGAACAAGG 
                   
                   
               
               
                   
                   
                   
                 CCCAGGGCGUGGAG 
                   
                   
               
               
                   
                   
                   
                 CUGGAGAUCAGAAA 
                   
                   
               
               
                   
                   
                   
                 GGACGACGGCAACA 
                   
                   
               
               
                   
                   
                   
                 CCAUCAUGGUGGUG 
                   
                   
               
               
                   
                   
                   
                 CAGAAGCAAGGGAA 
                   
                   
               
               
                   
                   
                   
                 CACCAGAUUCAGCG 
                   
                   
               
               
                   
                   
                   
                 CCGGCCAGAGAGUG 
                   
                   
               
               
                   
                   
                   
                 GUGCUGGCCAGCAA 
                   
                   
               
               
                   
                   
                   
                 CGGCGCCCAGGUGA 
                   
                   
               
               
                   
                   
                   
                 CCGUGAGCCCUCGC 
                   
                   
               
               
                   
                   
                   
                 CAUCACCACCACCA 
                   
                   
               
               
                   
                   
                   
                 CCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 138 
                 139 
                 140 
                 129 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 229 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 140, mRNA ORF SEQ ID NO: 139, and 3′ UTR SEQ ID NO: 129. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_CdtB_T 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACUCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 runc_IgK_ 
                   PDTTG YKVMTWNLQ 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 cHis 
                 GSSASTESKWNVNV 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 RQLLSGTAGVDILMV 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 QEAGAVPTSAVPTGR 
                 CGGCUACAAGGUGA 
                 UAAGAA 
                 GCCUAG 
               
               
                   
                   
                 HIQPFGVGIPIDEYTW 
                 UGACCUGGAACCUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 NLGTTSRQDIRYIYHS 
                 CAGGGAAGCUCCGC 
                 UAAGAC 
                 GCCCCU 
               
               
                   
                   
                 AIDVGARRVNLAIVS 
                 CAGCACCGAGAGCA 
                 CCCGGC 
                 UGGGCC 
               
               
                   
                   
                 RQRADNVYVLRPTT 
                 AGUGGAACGUGAAC 
                 GCCGCC 
                 UCCCCC 
               
               
                   
                   
                 VASRPVIGIGLGNDV 
                 GUGAGACAGCUCCU 
                 ACC 
                 CAGCCC 
               
               
                   
                   
                 FLTAHALASGGPDAA 
                 GAGCGGCACCGCCG 
                   
                 CUCCUC 
               
               
                   
                   
                 AIVRVTINFFRQPQM 
                 GCGUCGACAUCCUG 
                   
                 CCCUUC 
               
               
                   
                   
                 RHLSWFLAGDFNRSP 
                 AUGGUGCAGGAGGC 
                   
                 CUGCAC 
               
               
                   
                   
                 DRLENDLMTEHLER 
                 CGGAGCCGUCCCUA 
                   
                 CCGUAC 
               
               
                   
                   
                 VVAVLAPTEPTQIGG 
                 CCAGCGCCGUGCCU 
                   
                 CCCCGU 
               
               
                   
                   
                 GILDYGVIVDRAPYS 
                 ACCGGCAGACACAU 
                   
                 GGUCUU 
               
               
                   
                   
                 QRVEALRNPQLASDH 
                 CCAGCCUUUCGGCG 
                   
                 UGAAUA 
               
               
                   
                   
                 YPVAFLHHHHHH 
                 UGGGCAUCCCUAUC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 GACGAGUACACCUG 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 GAAUCUCGGCACCA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 CCAGCAGACAGGAC 
                   
                   
               
               
                   
                   
                   
                 AUCAGAUACAUCUA 
                   
                   
               
               
                   
                   
                   
                 CCACAGCGCCAUCG 
                   
                   
               
               
                   
                   
                   
                 ACGUGGGCGCCAGA 
                   
                   
               
               
                   
                   
                   
                 AGAGUGAACCUGGC 
                   
                   
               
               
                   
                   
                   
                 CAUCGUGAGCAGAC 
                   
                   
               
               
                   
                   
                   
                 AGAGAGCCGACAAC 
                   
                   
               
               
                   
                   
                   
                 GUGUACGUGCUGAG 
                   
                   
               
               
                   
                   
                   
                 GCCUACCACCGUGG 
                   
                   
               
               
                   
                   
                   
                 CCAGCAGACCUGUG 
                   
                   
               
               
                   
                   
                   
                 AUCGGCAUCGGCCU 
                   
                   
               
               
                   
                   
                   
                 GGGCAACGACGUGU 
                   
                   
               
               
                   
                   
                   
                 UCCUGACCGCCCAC 
                   
                   
               
               
                   
                   
                   
                 GCUCUGGCCUCCGG 
                   
                   
               
               
                   
                   
                   
                 UGGCCCCGACGCUG 
                   
                   
               
               
                   
                   
                   
                 CCGCCAUCGUGAGA 
                   
                   
               
               
                   
                   
                   
                 GUGACCAUCAACUU 
                   
                   
               
               
                   
                   
                   
                 CUUCAGACAGCCUC 
                   
                   
               
               
                   
                   
                   
                 AGAUGAGACACCUG 
                   
                   
               
               
                   
                   
                   
                 AGCUGGUUCCUGGC 
                   
                   
               
               
                   
                   
                   
                 CGGCGACUUCAACA 
                   
                   
               
               
                   
                   
                   
                 GAAGCCCUGACAGA 
                   
                   
               
               
                   
                   
                   
                 CUGGAGAACGACCU 
                   
                   
               
               
                   
                   
                   
                 GAUGACCGAGCACC 
                   
                   
               
               
                   
                   
                   
                 UGGAGAGAGUGGU 
                   
                   
               
               
                   
                   
                   
                 GGCCGUGCUGGCCC 
                   
                   
               
               
                   
                   
                   
                 CUACCGAGCCUACC 
                   
                   
               
               
                   
                   
                   
                 CAGAUCGGCGGCGG 
                   
                   
               
               
                   
                   
                   
                 CAUCCUGGACUACG 
                   
                   
               
               
                   
                   
                   
                 GCGUGAUCGUGGAC 
                   
                   
               
               
                   
                   
                   
                 AGAGCCCCUUACAG 
                   
                   
               
               
                   
                   
                   
                 CCAGAGAGUGGAGG 
                   
                   
               
               
                   
                   
                   
                 CCCUGAGAAACCCU 
                   
                   
               
               
                   
                   
                   
                 CAGCUGGCCAGCGA 
                   
                   
               
               
                   
                   
                   
                 CCACUACCCUGUGG 
                   
                   
               
               
                   
                   
                   
                 CCUUCCUGCAUCAC 
                   
                   
               
               
                   
                   
                   
                 CACCACCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 141 
                 142 
                 140 
                 129 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 230 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 140, mRNA ORF SEQ ID NO: 142, and 3′ UTR SEQ ID NO: 129. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_CdtB_T 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACUCCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 runc_H160 
                   PDTTG YKVMTWNLQ 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 Q_IgK_cH 
                 GSSASTESKWNVNV 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                 is 
                 RQLLSGTAGVDILMV 
                 CUGCCUGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 QEAGAVPTSAVPTGR 
                 CGGCUACAAGGUGA 
                 UAAGAA 
                 GCCUAG 
               
               
                   
                   
                 HIQPFGVGIPIDEYTW 
                 UGACCUGGAACCUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 NLGTTSRQDIRYIYHS 
                 CAGGGAAGCUCCGC 
                 UAAGAC 
                 GCCCCU 
               
               
                   
                   
                 AIDVGARRVNLAIVS 
                 CAGCACCGAGAGCA 
                 CCCGGC 
                 UGGGCC 
               
               
                   
                   
                 RQRADNVYVLRPTT 
                 AGUGGAACGUGAAC 
                 GCCGCC 
                 UCCCCC 
               
               
                   
                   
                 VASRPVIGIGLGNDV 
                 GUGAGACAGCUCCU 
                 ACC 
                 CAGCCC 
               
               
                   
                   
                 FLTAQALASGGPDAA 
                 GAGCGGCACCGCCG 
                   
                 CUCCUC 
               
               
                   
                   
                 AIVRVTINFFRQPQM 
                 GCGUCGACAUCCUG 
                   
                 CCCUUC 
               
               
                   
                   
                 RHLSWFLAGDFNRSP 
                 AUGGUGCAGGAGGC 
                   
                 CUGCAC 
               
               
                   
                   
                 DRLENDLMTEHLER 
                 CGGAGCCGUCCCUA 
                   
                 CCGUAC 
               
               
                   
                   
                 VVAVLAPTEPTQIGG 
                 CCAGCGCCGUGCCU 
                   
                 CCCCGU 
               
               
                   
                   
                 GILDYGVIVDRAPYS 
                 ACCGGCAGACACAU 
                   
                 GGUCUU 
               
               
                   
                   
                 QRVEALRNPQLASDH 
                 CCAGCCUUUCGGCG 
                   
                 UGAAUA 
               
               
                   
                   
                 YPVAFLHHHHHH 
                 UGGGCAUCCCUAUC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 GACGAGUACACCUG 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 GAAUCUCGGCACCA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 CCAGCAGACAGGAC 
                   
                   
               
               
                   
                   
                   
                 AUCAGAUACAUCUA 
                   
                   
               
               
                   
                   
                   
                 CCACAGCGCCAUCG 
                   
                   
               
               
                   
                   
                   
                 ACGUGGGCGCCAGA 
                   
                   
               
               
                   
                   
                   
                 AGAGUGAACCUGGC 
                   
                   
               
               
                   
                   
                   
                 CAUCGUGAGCAGAC 
                   
                   
               
               
                   
                   
                   
                 AGAGAGCCGACAAC 
                   
                   
               
               
                   
                   
                   
                 GUGUACGUGCUGAG 
                   
                   
               
               
                   
                   
                   
                 GCCUACCACCGUGG 
                   
                   
               
               
                   
                   
                   
                 CCAGCAGACCUGUG 
                   
                   
               
               
                   
                   
                   
                 AUCGGCAUCGGCCU 
                   
                   
               
               
                   
                   
                   
                 GGGCAACGACGUGU 
                   
                   
               
               
                   
                   
                   
                 UCCUGACCGCCCAG 
                   
                   
               
               
                   
                   
                   
                 GCUCUGGCCUCCGG 
                   
                   
               
               
                   
                   
                   
                 UGGCCCCGACGCUG 
                   
                   
               
               
                   
                   
                   
                 CCGCCAUCGUGAGA 
                   
                   
               
               
                   
                   
                   
                 GUGACCAUCAACUU 
                   
                   
               
               
                   
                   
                   
                 CUUCAGACAGCCUC 
                   
                   
               
               
                   
                   
                   
                 AGAUGAGACACCUG 
                   
                   
               
               
                   
                   
                   
                 AGCUGGUUCCUGGC 
                   
                   
               
               
                   
                   
                   
                 CGGCGACUUCAACA 
                   
                   
               
               
                   
                   
                   
                 GAAGCCCUGACAGA 
                   
                   
               
               
                   
                   
                   
                 CUGGAGAACGACCU 
                   
                   
               
               
                   
                   
                   
                 GAUGACCGAGCACC 
                   
                   
               
               
                   
                   
                   
                 UGGAGAGAGUGGU 
                   
                   
               
               
                   
                   
                   
                 GGCCGUGCUGGCCC 
                   
                   
               
               
                   
                   
                   
                 CUACCGAGCCUACC 
                   
                   
               
               
                   
                   
                   
                 CAGAUCGGCGGCGG 
                   
                   
               
               
                   
                   
                   
                 CAUCCUGGACUACG 
                   
                   
               
               
                   
                   
                   
                 GCGUGAUCGUGGAC 
                   
                   
               
               
                   
                   
                   
                 AGAGCCCCUUACAG 
                   
                   
               
               
                   
                   
                   
                 CCAGAGAGUGGAGG 
                   
                   
               
               
                   
                   
                   
                 CCCUGAGAAACCCU 
                   
                   
               
               
                   
                   
                   
                 CAGCUGGCCAGCGA 
                   
                   
               
               
                   
                   
                   
                 CCACUACCCUGUGG 
                   
                   
               
               
                   
                   
                   
                 CCUUCCUGCAUCAC 
                   
                   
               
               
                   
                   
                   
                 CACCACCACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 143 
                 144 
                 140 
                 129 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 231 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 140, mRNA ORF SEQ ID NO: 144, and 3′ UTR SEQ ID NO: 129. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_STY07 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACACCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 96_nIgK_c 
                   PDTTG QAPISSVGSGS 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 His 
                 VEDRVTQLERISNAH 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 SQLLTQLQQQLSDNQ 
                 CUGCCCGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 SDIDSLRGQIQENQY 
                 CGGCCAGGCCCCUA 
                 UAAGAA 
                 GCCUAG 
               
               
                   
                   
                 QLNQVMERQKQIML 
                 UCAGCAGCGUGGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 QLGSLNNGGAAQPA 
                 AGCGGAAGCGUGGA 
                 UAAGAC 
                 GCCCCU 
               
               
                   
                   
                 AGDQSGAATAATPA 
                 GGACAGAGUGACCC 
                 CCCGGC 
                 UGGGCC 
               
               
                   
                   
                 PDAGTATSGAPVQSG 
                 AGCUGGAGAGAAUC 
                 GCCGCC 
                 UCCCCC 
               
               
                   
                   
                 DANTDYNAAIALVQ 
                 AGCAACGCCCACAG 
                 ACC 
                 CAGCCC 
               
               
                   
                   
                 DKSRQDDAIVAFQNF 
                 CCAGCUGCUCACCC 
                   
                 CUCCUC 
               
               
                   
                   
                 IKKYPDSTYQPNANY 
                 AGCUCCAGCAGCAG 
                   
                 CCCUUC 
               
               
                   
                   
                 WLGQLNYNKGKKD 
                 CUGAGCGACAACCA 
                   
                 CUGCAC 
               
               
                   
                   
                 DAAYYFASVVKNYP 
                 GAGCGACAUCGACA 
                   
                 CCGUAC 
               
               
                   
                   
                 KSPKAADAMYKVGV 
                 GCCUGAGAGGCCAG 
                   
                 CCCCGU 
               
               
                   
                   
                 IMQDKGDTAKAKAV 
                 AUCCAGGAGAACCA 
                   
                 GGUCUU 
               
               
                   
                   
                 YQQVINKYPGTDGA 
                 GUACCAGCUGAACC 
                   
                 UGAAUA 
               
               
                   
                   
                 KQAQKRLNAMHHH 
                 AGGUGAUGGAGAG 
                   
                 AAGUCU 
               
               
                   
                   
                 HHH 
                 ACAGAAGCAGAUCA 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 UGCUGCAGCUGGGA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 AGCCUGAACAACGG 
                   
                   
               
               
                   
                   
                   
                 CGGAGCCGCUCAGC 
                   
                   
               
               
                   
                   
                   
                 CUGCAGCCGGCGAC 
                   
                   
               
               
                   
                   
                   
                 CAGAGUGGCGCCGC 
                   
                   
               
               
                   
                   
                   
                 AACAGCCGCCACAC 
                   
                   
               
               
                   
                   
                   
                 CAGCCCCUGACGCG 
                   
                   
               
               
                   
                   
                   
                 GGUACAGCCACCAG 
                   
                   
               
               
                   
                   
                   
                 CGGUGCUCCCGUGC 
                   
                   
               
               
                   
                   
                   
                 AGAGCGGCGACGCC 
                   
                   
               
               
                   
                   
                   
                 AACACCGACUACAA 
                   
                   
               
               
                   
                   
                   
                 CGCCGCCAUCGCCC 
                   
                   
               
               
                   
                   
                   
                 UGGUGCAGGACAAG 
                   
                   
               
               
                   
                   
                   
                 AGCAGACAGGACGA 
                   
                   
               
               
                   
                   
                   
                 CGCUAUCGUGGCCU 
                   
                   
               
               
                   
                   
                   
                 UCCAGAACUUCAUC 
                   
                   
               
               
                   
                   
                   
                 AAGAAGUACCCCGA 
                   
                   
               
               
                   
                   
                   
                 CAGCACCUACCAGC 
                   
                   
               
               
                   
                   
                   
                 CCAACGCCAACUAC 
                   
                   
               
               
                   
                   
                   
                 UGGCUGGGCCAGCU 
                   
                   
               
               
                   
                   
                   
                 GAACUACAACAAGG 
                   
                   
               
               
                   
                   
                   
                 GCAAGAAGGACGAC 
                   
                   
               
               
                   
                   
                   
                 GCCGCCUACUACUU 
                   
                   
               
               
                   
                   
                   
                 CGCCAGCGUGGUGA 
                   
                   
               
               
                   
                   
                   
                 AGAACUACCCCAAG 
                   
                   
               
               
                   
                   
                   
                 AGCCCCAAAGCGGC 
                   
                   
               
               
                   
                   
                   
                 CGACGCCAUGUACA 
                   
                   
               
               
                   
                   
                   
                 AGGUGGGCGUGAUC 
                   
                   
               
               
                   
                   
                   
                 AUGCAGGACAAGGG 
                   
                   
               
               
                   
                   
                   
                 CGACACCGCCAAGG 
                   
                   
               
               
                   
                   
                   
                 CCAAGGCCGUGUAC 
                   
                   
               
               
                   
                   
                   
                 CAGCAGGUGAUCAA 
                   
                   
               
               
                   
                   
                   
                 CAAGUACCCCGGUA 
                   
                   
               
               
                   
                   
                   
                 CUGACGGCGCCAAG 
                   
                   
               
               
                   
                   
                   
                 CAGGCCCAGAAGAG 
                   
                   
               
               
                   
                   
                   
                 ACUGAACGCCAUGC 
                   
                   
               
               
                   
                   
                   
                 ACCAUCACCAUCAC 
                   
                   
               
               
                   
                   
                   
                 CAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 145 
                 146 
                 140 
                 129 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 232 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 140, mRNA ORF SEQ ID NO: 146, and 3′ UTR SEQ ID NO: 129. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_STY07 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAGACACCUGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 96_NGM_ 
                   PDTTG QAPISSVGSGS 
                 CCAGCUGCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 nIgK_cHis 
                 VEDRVTQLERISNAH 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 SQLLTQLQQQLSDNQ 
                 CUGCCCGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 ADIDSLRGQIQENQY 
                 CGGCCAGGCCCCUA 
                 UAAGAA 
                 GCCUAG 
               
               
                   
                   
                 QLNQVMERQKQIML 
                 UCAGCAGCGUGGGC 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 QLGSLNNGGAAQPA 
                 AGCGGAAGCGUGGA 
                 UAAGAC 
                 GCCCCU 
               
               
                   
                   
                 AGDQSGAATAATPA 
                 GGACAGAGUGACCC 
                 CCCGGC 
                 UGGGCC 
               
               
                   
                   
                 PDAGTATSGAPVQSG 
                 AGCUGGAGAGAAUC 
                 GCCGCC 
                 UCCCCC 
               
               
                   
                   
                 DANTDYNAAIALVQ 
                 AGCAACGCCCACAG 
                 ACC 
                 CAGCCC 
               
               
                   
                   
                 DKSRQDDAIVAFQNF 
                 CCAGCUGCUCACCC 
                   
                 CUCCUC 
               
               
                   
                   
                 IKKYPDSTYQPNANY 
                 AGCUCCAGCAGCAG 
                   
                 CCCUUC 
               
               
                   
                   
                 WLGQLNYNKGKKD 
                 CUGAGCGACAACCA 
                   
                 CUGCAC 
               
               
                   
                   
                 DAAYYFASVVKNYP 
                 GGCCGACAUCGACA 
                   
                 CCGUAC 
               
               
                   
                   
                 KSPKAADAMYKVGV 
                 GCCUGAGAGGCCAG 
                   
                 CCCCGU 
               
               
                   
                   
                 IMQDKGDTAKAKAV 
                 AUCCAGGAGAACCA 
                   
                 GGUCUU 
               
               
                   
                   
                 YQQVINKYPGTDGA 
                 GUACCAGCUGAACC 
                   
                 UGAAUA 
               
               
                   
                   
                 KQAQKRLNAMHHH 
                 AGGUGAUGGAGAG 
                   
                 AAGUCU 
               
               
                   
                   
                 HHH 
                 ACAGAAGCAGAUCA 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 UGCUGCAGCUGGGA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 AGCCUGAACAACGG 
                   
                   
               
               
                   
                   
                   
                 CGGAGCCGCUCAGC 
                   
                   
               
               
                   
                   
                   
                 CUGCAGCCGGCGAC 
                   
                   
               
               
                   
                   
                   
                 CAGAGUGGCGCCGC 
                   
                   
               
               
                   
                   
                   
                 AACAGCCGCCACAC 
                   
                   
               
               
                   
                   
                   
                 CAGCCCCUGACGCG 
                   
                   
               
               
                   
                   
                   
                 GGUACAGCCACCAG 
                   
                   
               
               
                   
                   
                   
                 CGGUGCUCCCGUGC 
                   
                   
               
               
                   
                   
                   
                 AGAGCGGCGACGCC 
                   
                   
               
               
                   
                   
                   
                 AACACCGACUACAA 
                   
                   
               
               
                   
                   
                   
                 CGCCGCCAUCGCCC 
                   
                   
               
               
                   
                   
                   
                 UGGUGCAGGACAAG 
                   
                   
               
               
                   
                   
                   
                 AGCAGACAGGACGA 
                   
                   
               
               
                   
                   
                   
                 CGCUAUCGUGGCCU 
                   
                   
               
               
                   
                   
                   
                 UCCAGAACUUCAUC 
                   
                   
               
               
                   
                   
                   
                 AAGAAGUACCCCGA 
                   
                   
               
               
                   
                   
                   
                 CAGCACCUACCAGC 
                   
                   
               
               
                   
                   
                   
                 CCAACGCCAACUAC 
                   
                   
               
               
                   
                   
                   
                 UGGCUGGGCCAGCU 
                   
                   
               
               
                   
                   
                   
                 GAACUACAACAAGG 
                   
                   
               
               
                   
                   
                   
                 GCAAGAAGGACGAC 
                   
                   
               
               
                   
                   
                   
                 GCCGCCUACUACUU 
                   
                   
               
               
                   
                   
                   
                 CGCCAGCGUGGUGA 
                   
                   
               
               
                   
                   
                   
                 AGAACUACCCCAAG 
                   
                   
               
               
                   
                   
                   
                 AGCCCCAAAGCGGC 
                   
                   
               
               
                   
                   
                   
                 CGACGCCAUGUACA 
                   
                   
               
               
                   
                   
                   
                 AGGUGGGCGUGAUC 
                   
                   
               
               
                   
                   
                   
                 AUGCAGGACAAGGG 
                   
                   
               
               
                   
                   
                   
                 CGACACCGCCAAGG 
                   
                   
               
               
                   
                   
                   
                 CCAAGGCCGUGUAC 
                   
                   
               
               
                   
                   
                   
                 CAGCAGGUGAUCAA 
                   
                   
               
               
                   
                   
                   
                 CAAGUACCCCGGUA 
                   
                   
               
               
                   
                   
                   
                 CUGACGGCGCCAAG 
                   
                   
               
               
                   
                   
                   
                 CAGGCCCAGAAGAG 
                   
                   
               
               
                   
                   
                   
                 ACUGAACGCCAUGC 
                   
                   
               
               
                   
                   
                   
                 ACCAUCACCAUCAC 
                   
                   
               
               
                   
                   
                   
                 CAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 147 
                 148 
                 140 
                 129 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 233 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 140, mRNA ORF SEQ ID NO: 148, and 3′ UTR SEQ ID NO: 129. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_STY10 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAAACCCCAGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 86_nIgK_c 
                   PDTTG ENKSYYQLPI 
                 CCAGCUCCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 His 
                 AQSGVQSTASQGNRL 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 LWVEQVSVPDYLAG 
                 CUUCCCGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 NGVVYQTSDVQYVI 
                 CGGCGAGAACAAGA 
                 UAAGAA 
                 GCCUAG 
               
               
                   
                   
                 ANNNLWASPLDQQL 
                 GCUACUACCAGCUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 RNTLVANLSARLPG 
                 CCCAUCGCCCAGAG 
                 UAAGAC 
                 GCCCCU 
               
               
                   
                   
                 WVVASQPLGTTQDT 
                 CGGCGUGCAGAGCA 
                 CCCGGC 
                 UGGGCC 
               
               
                   
                   
                 LNVTVTGFHGRYDG 
                 CAGCCAGCCAGGGC 
                 GCCGCC 
                 UCCCCC 
               
               
                   
                   
                 KVIVSGEWLLNHNG 
                 AACAGACUGCUGUG 
                 ACC 
                 CAGCCC 
               
               
                   
                   
                 QLIKRPFHIEASQQKD 
                 GGUGGAGCAGGUGA 
                   
                 CUCCUC 
               
               
                   
                   
                 GYDEMVKVLASAWS 
                 GCGUGCCCGACUAC 
                   
                 CCCUUC 
               
               
                   
                   
                 QEAAAIADEIKRLPH 
                 CUGGCCGGCAACGG 
                   
                 CUGCAC 
               
               
                   
                   
                 HHHHH 
                 CGUGGUGUACCAGA 
                   
                 CCGUAC 
               
               
                   
                   
                   
                 CCAGCGACGUGCAG 
                   
                 CCCCGU 
               
               
                   
                   
                   
                 UACGUGAUCGCCAA 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 CAACAACCUGUGGG 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 CCAGCCCGCUGGAC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 CAGCAGCUGAGAAA 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CACCCUGGUGGCCA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 ACCUGAGCGCCAGA 
                   
                   
               
               
                   
                   
                   
                 CUCCCCGGCUGGGU 
                   
                   
               
               
                   
                   
                   
                 CGUUGCCUCCCAGC 
                   
                   
               
               
                   
                   
                   
                 CCCUGGGCACCACC 
                   
                   
               
               
                   
                   
                   
                 CAGGACACCCUGAA 
                   
                   
               
               
                   
                   
                   
                 CGUGACCGUGACCG 
                   
                   
               
               
                   
                   
                   
                 GCUUCCACGGCAGA 
                   
                   
               
               
                   
                   
                   
                 UACGACGGCAAGGU 
                   
                   
               
               
                   
                   
                   
                 GAUCGUGAGCGGCG 
                   
                   
               
               
                   
                   
                   
                 AGUGGCUGCUGAAC 
                   
                   
               
               
                   
                   
                   
                 CACAACGGCCAGCU 
                   
                   
               
               
                   
                   
                   
                 GAUCAAGAGGCCCU 
                   
                   
               
               
                   
                   
                   
                 UCCACAUCGAGGCC 
                   
                   
               
               
                   
                   
                   
                 AGCCAGCAGAAGGA 
                   
                   
               
               
                   
                   
                   
                 CGGCUACGACGAGA 
                   
                   
               
               
                   
                   
                   
                 UGGUGAAGGUGCUG 
                   
                   
               
               
                   
                   
                   
                 GCCAGCGCCUGGAG 
                   
                   
               
               
                   
                   
                   
                 CCAGGAGGCCGCUG 
                   
                   
               
               
                   
                   
                   
                 CCAUAGCCGACGAG 
                   
                   
               
               
                   
                   
                   
                 AUCAAGAGACUGCC 
                   
                   
               
               
                   
                   
                   
                 CCACCAUCACCACC 
                   
                   
               
               
                   
                   
                   
                 ACCAC 
               
               
                   
               
               
                   
               
               
                 SEQ ID NO: 
                   
                 149 
                 150 
                 140 
                 129 
               
               
                   
               
            
           
           
               
            
               
                 SEQ ID NO: 234 consists of from 5′ end to 3′ end, 5′ UTR SEQ 
               
               
                 ID NO: 140, mRNA ORF SEQ ID NO: 150, and 3′ UTR SEQ ID NO: 129. 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 St_STY10 
                 
                   METPAQLLFLLLLWL 
                 
                 AUGGAAACCCCAGC 
                 GGGAAA 
                 UGAUAA 
               
               
                   
                 86_NGM_ 
                   PDTTG ENKAYYQLPI 
                 CCAGCUCCUGUUCC 
                 UAAGAG 
                 UAGGCU 
               
               
                   
                 nIgK_cHis 
                 AQSGVQSTASQGNRL 
                 UGCUGCUGCUGUGG 
                 AGAAAA 
                 GGAGCC 
               
               
                   
                   
                 LWVEQVSVPDYLAG 
                 CUUCCCGACACCAC 
                 GAAGAG 
                 UCGGUG 
               
               
                   
                   
                 NGVVYQTSDVQYVI 
                 CGGCGAGAACAAGG 
                 UAAGAA 
                 GCCUAG 
               
               
                   
                   
                 ANNNLWASPLDQQL 
                 CCUACUACCAGCUG 
                 GAAAUA 
                 CUUCUU 
               
               
                   
                   
                 RNTLVANLAARLPG 
                 CCCAUCGCCCAGAG 
                 UAAGAC 
                 GCCCCU 
               
               
                   
                   
                 WVVASQPLGTTQDT 
                 CGGCGUGCAGAGCA 
                 CCCGGC 
                 UGGGCC 
               
               
                   
                   
                 LNVAVTGFHGRYDG 
                 CAGCCAGCCAGGGC 
                 GCCGCC 
                 UCCCCC 
               
               
                   
                   
                 KVIVSGEWLLNHNG 
                 AACAGACUGCUGUG 
                 ACC 
                 CAGCCC 
               
               
                   
                   
                 QLIKRPFHIEASQQKD 
                 GGUGGAGCAGGUGA 
                   
                 CUCCUC 
               
               
                   
                   
                 GYDEMVKVLASAWS 
                 GCGUGCCCGACUAC 
                   
                 CCCUUC 
               
               
                   
                   
                 QEAAAIADEIKRLPH 
                 CUGGCCGGCAACGG 
                   
                 CUGCAC 
               
               
                   
                   
                 HHHHH 
                 CGUGGUGUACCAGA 
                   
                 CCGUAC 
               
               
                   
                   
                   
                 CCAGCGACGUGCAG 
                   
                 CCCCGU 
               
               
                   
                   
                   
                 UACGUGAUCGCCAA 
                   
                 GGUCUU 
               
               
                   
                   
                   
                 CAACAACCUGUGGG 
                   
                 UGAAUA 
               
               
                   
                   
                   
                 CCAGCCCGCUGGAC 
                   
                 AAGUCU 
               
               
                   
                   
                   
                 CAGCAGCUGAGAAA 
                   
                 GAGUGG 
               
               
                   
                   
                   
                 CACCCUGGUGGCCA 
                   
                 GCGGC 
               
               
                   
                   
                   
                 ACCUGGCCGCCAGA 
                   
                   
               
               
                   
                   
                   
                 CUCCCCGGCUGGGU 
                   
                   
               
               
                   
                   
                   
                 CGUUGCCUCCCAGC 
                   
                   
               
               
                   
                   
                   
                 CCCUGGGCACCACC 
                   
                   
               
               
                   
                   
                   
                 CAGGACACCCUGAA 
                   
                   
               
               
                   
                   
                   
                 CGUGGCCGUGACCG 
                   
                   
               
               
                   
                   
                   
                 GCUUCCACGGCAGA 
                   
                   
               
               
                   
                   
                   
                 UACGACGGCAAGGU 
                   
                   
               
               
                   
                   
                   
                 GAUCGUGAGCGGCG 
                   
                   
               
               
                   
                   
                   
                 AGUGGCUGCUGAAC 
                   
                   
               
               
                   
                   
                   
                 CACAACGGCCAGCU 
                   
                   
               
               
                   
                   
                   
                 GAUCAAGAGGCCCU 
                   
                   
               
               
                   
                   
                   
                 UCCACAUCGAGGCC 
                   
                   
               
               
                   
                   
                   
                 AGCCAGCAGAAGGA 
                   
                   
               
               
                   
                   
                   
                 CGGCUACGACGAGA 
                   
                   
               
               
                   
                   
                   
                 UGGUGAAGGUGCUG 
                   
                   
               
               
                   
                   
                   
                 GCCAGCGCCUGGAG 
                   
                   
               
               
                   
                   
                   
                 CCAGGAGGCCGCUG 
                   
                   
               
               
                   
                   
                   
                 CCAUAGCCGACGAG 
                   
                   
               
               
                   
                   
                   
                 AUCAAGAGACUGCC 
                   
                   
               
               
                   
                   
                   
                 CCACCAUCACCACC 
                   
                   
               
               
                   
                   
                   
                 ACCAC