Patent Publication Number: US-2023158241-A1

Title: Needle-free injection system

Description:
REFERENCE TO RELATED APPLICATIONS 
     This non-provisional application claims priority claim under 35 U.S.C. § 119(a) on Taiwan Patent Application No. 110144048 (filed Nov. 25, 2021), No. 110214033 (filed Nov. 25, 2021), No. 110215138 (filed Dec. 20, 2021) and No. 111120710 (filed Jun. 2, 2022), the entire contents of which are incorporated herein by reference. 
     FIELD OF THE INVENTION 
     The present invention relates to a needle-free injection system, which can inject a delivery material into the cells of a target object by a high-pressure gas, thereby reducing discomfort and injection risks caused by traditional intramuscular injection needles. 
     BACKGROUND 
     A needle-free injection system, such as a gene gun, is a gene transfer device. The needle-free injection system mainly dissolves a delivery material in a solution or adheres to the surface of a metal particle, such as tungsten or gold powder, and then uses a high-pressure gas to accelerate the solution or metal particle, so that the delivery material can be injected in a cell body (target object) such as a skin tissue, a cell wall or a cell membrane. The delivery material can be a medicine, a biological substance, a DNA or an RNA. The needle-free injection system is widely used in the fields of gene transfer of animals or plants, DNA vaccines, gene therapy or aesthetic medicine. 
     A conventional needle-free injection system  10  is shown in  FIG.  1   , mainly includes a pressure accumulator  11 , an output pipe  15  and a hand-holding device  17 . The output pipe  15  is fixed at the front end of the pressure accumulator  11 , and the hand-holding device  17  is fixed at the bottom end of the pressure accumulator  11 . The pressure accumulator  11  can be connected to a fluid supply device  19 . The fluid supply device  19  includes a gas cylinder  191 , a pressure regulator  193  and a gas delivery pipe  195 . By adjusting the pressure regulator  193 , a high-pressure gas in the gas cylinder  191  can be controlled to be transmitted to the pressure accumulator  11  through the gas delivery pipe  195 . 
     The output pipe  15  is provided with a charging hole  159 , and a delivery material (not shown) is put into the output pipe  15  through the charging hole  159 . The high-pressure gas will be accelerated when passing through the output pipe  15 , and will drive the delivery material in the output pipe  15  to be injected into a target object (cell body). 
     The needle-free injection systems can utilize a gunpowder explosion, a high voltage, or a high-pressure gas as a power source to accelerate metal particles or solutions that include a delivery material. The structure of the conventional needle-free injection system is very complicated, which not only increases the cost and difficulty of production, but also may affect the gene transfer effect due to the poor production quality of the needle-free injection system. 
     SUMMARY 
     It is a primary object of the present invention to provide a needle-free injection system, which can quickly connect or disassemble the output pipe and the pressure accumulator through an adapter tube. Through the adapter tube, the disadvantage of the output tube being loose during use can be avoided, and the convenience during use can be improved. 
     It is another object of the present invention to provide a needle-free injection system, which can fix the control panel on the outer surface of the pressure accumulator, so that the user can adjust a delivery procedure for putting the delivery material into the output pipe at any time, which can include Calibration, positioning, delivery time, number of deliveries and/or number of deliveries, thus improving ease of use. 
     It is another object of the present invention to provide a needle-free injection system. A touch control panel is fixed on the outer surface of the pressure accumulator, so as to abandon a physical wire to connect an external controller, so the needle-free injection system can be reduce its usage space and placement space. 
     It is another object of the present invention to provide a needle-free injection system, which will use the two ends of an adapter tube to connect the pressure accumulator and the output pipe individually, thereby not only improving the convenience of manufacture, but also reducing the turbulence flow in the output pipe and improve the effect of gene transfer. 
     It is another object of the present invention to provide a needle-free injection system, which can inject a proliferative agent (delivery material) into a treatment site of a patient at high speed without using an injection needle for acupuncture. The invention can relieve pain and discomfort of patients during treatment. 
     To achieve the above objective, the present invention provides a needle-free injection system, comprising: a pressure accumulator, one end of which is provided with an output portion; an output pipe, includes a connecting port, an ejection port and at least one connecting convex portion, wherein said connecting port and said ejection port are respectively located at two ends of said output pipe, and an accommodating space is formed between said connecting port and said ejection port, a dividing unit is arranged in said accommodating space, and at least one neck channel is arranged inside said dividing unit or between said dividing unit and an inner wall of said output pipe, said connecting convex portion is located on the outer surface of said output pipe, the outer surface of said output pipe is provided with a charging hole, which can be connected to said accommodating space; an adapter tube, includes a first connecting end, a second connecting end and at least one engaging groove, said first connecting end and said second connecting end are respectively located at two ends of said adapter tube, said engaging groove is located on said adapter tube, said first connection end can be sleeved on said output portion of said pressure accumulator, said connection port of said output pipe can enter said adapter tube from said second connection end and be connected to said output portion of said pressure accumulator, said connecting convex portion of said output pipe can be engaged with said engaging groove of said adapter tube; and a hand-holding device, fixed on the bottom end or the outer surface of said pressure accumulator, includes a shooting button for controlling a high-pressure gas entering or leaving said pressure accumulator. 
     To achieve the above objective, the present invention provides a needle-free injection system, comprising: a pressure accumulator, comprising an output portion and a power controller, said output portion is arranged at one end of said pressure accumulator, said power controller can control a power source to leave said pressure accumulator from said output portion; an output pipe, the two ends of said output pipe are respectively a connection port and an ejection port, an accommodating space is formed between said connection port and said ejection port, said connection port is connected to said output portion of said pressure accumulator, the outer surface of said output pipe is provided with a charging hole that can communicate with said accommodating space, and a dividing unit is arranged in said accommodating space; a delivery device, located at the top side of said pressure accumulator, has a driving device, a material storage member and a material delivery pipe, said material delivery pipe is arranged at the front end of the material storage member and communicated with said charging hole of said output pipe, said material storage member is used for placing a proliferating agent or a delivery material, said driving device can move forward and backward, thereby pushes said proliferating agent or said delivery material in said material storage member through said material delivery pipe and said charging hole into said accommodation space; a shooting button, connected to said power controller of said pressure accumulator; and a control panel, has a display and at least one control key, said control panel is electrically connected to the delivery device. 
     To achieve the above objective, the present invention provides a needle-free injection system, comprising: a pressure accumulator, one end of which is provided with an output portion; an output pipe, the two ends of which are respectively a connection port and an ejection port, an accommodating space is formed between said connection port and said ejection port, said connection port is connected to said output portion of said pressure accumulator, and the outer surface of said output pipe is provided with a charging hole that can be connected to said accommodating space; a shooting button, which is connected to said pressure accumulator to control a high-pressure gas entering or leaving said pressure accumulator; a delivery device, comprising a material storage member and a material delivery pipe, said material storage member is used for storing a delivery material, said material delivery pipe is connected to said charging hole of said output pipe; and a control panel, fixed on the outer surface of said pressure accumulator, the outer surface of said output pipe, or a portable control panel, said control panel has a display and at least one control key, said control panel is electrically connected to said delivery device. 
     In one embodiment of the present invention, wherein said dividing unit of said output tube has a first surface and a second surface, said first surface having a convex shape faces said connection port, and said second surface faces said ejection port, the distance between said first surface and said inner wall is gradually reduced from said connection port to said ejection port, the distance between said second surface and said inner wall are gradually increases from said connection port to said ejection port. 
     In one embodiment of the present invention, wherein said pressure accumulator includes a pressure trimmer, said pressure accumulator can be connected to a fluid supply device, said fluid supply device provides said high-pressure gas and leads said high-pressure gas into said pressure accumulator. 
     In one embodiment of the present invention, wherein said output portion of said pressure accumulator is provided with at least one fixing groove, said adapter tube is provided with a fixing hole corresponding to the position of said fixing groove, and a fixing member can pass through said fixing hole, so that said pressure accumulator is fixed on said adapter tube, said pressure accumulator is provided with a second locking hole adjacent to said output portion, said adapter tube is provided with a first locking hole corresponding to said second locking hole, and a locking piece can pass through said first locking hole and be fixed to said second locking hole. 
     In one embodiment of the present invention, wherein said pressure accumulator contains a solenoid valve, which is electrically connected to said shooting button and a power supply device, said pressure accumulator is connected to a control panel, which has a display and at least one control key. 
     In one embodiment of the present invention, wherein said control panel and said shooting button are fixed on the outer surface of said pressure accumulator or the outer surface of said output pipe. 
     In one embodiment of the present invention, wherein said control panel is a touch panel, said control key and said shooting button are an image control key and an image shooting key in said display. 
     In one embodiment of the present invention, wherein the bottom end or the outer casing of said pressure accumulator is fixedly provided with a hand-holding device, said shooting button is arranged on said hand-holding device. 
     In one embodiment of the present invention, wherein said pressure accumulator further comprises a pressure accumulating chamber, said pressure accumulator is connected to a power supply device, said power supply device provides said power, said power controller is located in said pressure accumulating chamber, said power controller is a solenoid valve. 
     In one embodiment of the present invention, wherein said output pipe is a jet engine type output pipe or a venturi type output pipe. 
     In one embodiment of the present invention, wherein said control panel is a touch panel, said control key is an image control key in said display, said shooting button is a physical button or an image shooting key in said display. 
     In one embodiment of the present invention, wherein said control panel is fixed to the top surface, the side surface, or the rear surface of said pressure accumulator, and the shooting button is provided on the outer surface of said pressure accumulator. 
     In one embodiment of the present invention, further comprising a hand-holding device fixed on the bottom end of said pressure accumulator, said shooting button is arranged on said hand-holding device, and said pressure accumulator is connected to a fluid supply device that provides said high-pressure gas for input to said pressure accumulator. 
     In one embodiment of the present invention, wherein said pressure accumulator is provided with a solenoid valve, said solenoid valve is electrically connected to said shooting button. 
     In one embodiment of the present invention, wherein said output pipe is a jet engine type output pipe or a venturi type output pipe. 
     In one embodiment of the present invention, further comprising an adapter tube, said adapter tube has a first connection end and a second connection end, said first connection end is used to connect and fix said pressure accumulator, and said second connection end is used to connect and fix said output pipe, so that said pressure accumulator is connected to said output pipe. 
     In one embodiment of the present invention, wherein said portable control panel comprises a wireless transmitter, said portable control panel is electrically connected to said delivery device by using said wireless transmitter, and the outer surface of said pressure accumulator is provided with a panel holder. 
     In one embodiment of the present invention, wherein said pressure accumulator is provided with a signal receiver, and said signal receiver can be electrically connected to said wireless transmitter of said control panel. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The structure as well as preferred modes of use, further objects, and advantages of this present disclosure will be best understood by referring to the following detailed description of some illustrative embodiments in conjunction with the accompanying drawings, in which: 
         FIG.  1    is a schematic diagram of a needle-free injection system in the prior art. 
         FIG.  2    is an exploded schematic diagram of an embodiment of the needle-free injection system of the present invention. 
         FIG.  3    is a side view of the needle-free injection system of the present invention. 
         FIG.  4    is a cross-sectional view of the output pipe of the present invention. 
         FIG.  5    is a side view of another embodiment of the needle-free injection system of the present invention. 
         FIG.  6    is a side view of another embodiment of the needle-free injection system of the present invention. 
         FIG.  7    is an exploded schematic diagram of another embodiment of the needle-free injection system of the present invention. 
         FIG.  8    is a side view of another embodiment of the needle-free injection system of the present invention. 
         FIG.  9    is a cross-sectional view of a venturi-type output pipe of the present invention. 
         FIG.  10    is a side view of another embodiment of the needle-free injection system of the present invention. 
         FIG.  11    is a side view of another embodiment of the needle-free injection system of the present invention. 
         FIG.  12    is a schematic diagram of another embodiment of the needle-free injection system of the present invention. 
         FIG.  13    is a side view of a preferred embodiment of the needle-free injection system of the present invention. 
         FIG.  14    is a schematic diagram of using of another embodiment of the needle-free injection system of the present invention. 
         FIG.  15    is a side view of another embodiment of the needle-free injection system of the present invention. 
     
    
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     Referring to  FIG.  2   ,  FIG.  3    and  FIG.  4   , the needle-free injection system  30  of the present invention mainly includes a pressure accumulator  40 , an adapter tube  50  and an output pipe  60 . The two sides of the transfer pipe  50  are respectively connected to the pressure accumulator  40  and the output pipe  60 . The pressure accumulator  40  includes an output portion  41 , and outputs a power source A through the output portion  41 . The power source A such as but not limited to a high-pressure gas. Specifically, the pressure accumulator  40  includes a pressure accumulating chamber and at least one valve, wherein the pressure accumulating chamber is connected to a fluid supply device  80  through the valve. When one of the valves is opened, the high-pressure gas A will be delivered to the pressure accumulator  40  by the fluid supply device  80 , so that the gas pressure in the pressure accumulator  40  is greater than that of the outside world, for example, greater than one atmosphere. When another valve is opened, the high-pressure gas A in the pressure accumulator  40  can be output by the output portion  41  and leave the pressure accumulator  40 . 
     The output pipe  60  includes a connecting port  61 , an ejection port  63  and at least one connecting convex portion  65 . The connection port  61  and the ejection port  63  are respectively located at two ends of the output pipe  60 , and the connection convex portion  65  is located on an outer surface of the output pipe  60 . The connection port  61  of the output pipe  60  is used to connect the output portion  41  of the pressure accumulator  40 . The high-pressure gas A output from the output portion  41  of the pressure accumulator  40  will be introduced into the connection port  61  of the output pipe  60 , and then pass through the ejection port  63  of the output pipe  60  is ejected to the outside. The high-pressure gas A will be accelerated in the process of passing through the output pipe  60 , and the higher-speed gas will be ejected from the ejection port  63 , which can also shoot a delivery material to a target object (eg, a cell body). 
     In an embodiment of the present invention, the output portion  41  has a concave part, and the connection port  61  has a convex part. When the connection port  61  is connected to the output portion  41 , the convex part of the connection port  61  will be inserted into the concave part of the output portion  41 , so as to achieve the purpose of the pressure accumulator  40  and the output pipe  60  being in close contact. A dividing unit  67  is disposed in the accommodating space  62 , and the dividing unit  67  can be used to divide the accommodating space  62  into two connected spaces. The output pipe  60  of this embodiment is a jet engine type output pipe, and the dividing unit  67  can be a conical-shaped, a spindle-shaped or an olive-shaped object. The dividing unit  67  includes at least one first surface  671  and at least one second surface  673 , and at least one neck channel  68  is disposed inside the dividing unit  67  or between the dividing unit  67  and the inner wall  64 . 
     The first surface  671  with a convex configuration faces the connection port  61  of the output pipe  60 . The space between the first surface  671  and the inner wall  64  of the output pipe  60  is formed to gradually decrease from the connection port  61  to the ejection port  63 . In addition, the second surface  673  faces the ejection port  63  of the output pipe  60 . The space between the second surface  673  and the inner wall  64  is formed to gradually increase from the connection port  61  to the ejection port  63 . The speed of the high-pressure gas A can be accelerated through the jet engine type output pipe  60  of the present invention. 
     In another embodiment of the present invention, the second surface  673  can also be designed as a vertical plane configuration, which is different from the convex configuration shown in the figure. The second surface  673  of the vertical plane structure can also accelerate the speed of the high-pressure gas A input from the connection port  61  and ejected from the ejection port  63 . 
     Since the dividing unit  67  of the present invention has the first surface  671  of the convex configuration, the high-pressure gas A can be guided to flow to the neck channel  68  close to the position of the inner wall  64  without being concentrated in the central area of the accommodating space  62 . In other words, when the high-pressure gas A carries the solution or metal particles with the delivery material and shoots toward the ejection port  63 , the solution or metal particles can be uniformly distributed over the entire cross-sectional area of the ejection port  63  instead of being concentrated in the central area. Therefore, the present invention can improve the transgenic effect of the delivery material, and can also reduce the damage caused by the high-pressure gas A to the target object. 
     The output pipe  60  further includes a charging hole  69 , which can penetrate the inner wall  64  of the output pipe  60  and is connected to the accommodating space  62 . The solution or metal particles with the delivery material can be fed into the accommodating space  62  through the charging hole  69 . When the high-pressure gas A is input from the connection port  61  and passes through the output pipe  60 , it will drive the delivery material in the accommodating space  62  to move toward the ejection port  63  and exit the needle-free injection system  30  from the ejection port  63 . 
     The adapter tube  50  includes a first connecting end  51 , a second connecting end  53  and at least one engaging groove  55 . The first connection end  51  and the second connection end  53  are located at two ends of the adapter tube  50  respectively. The engaging groove  55  is located on an inner surface of the adapter tube  50  or forms a groove. The first connection end  51  of the adapter tube  50  can be sleeved on the output portion  41  of the pressure accumulator  40 , and the second connection end  53  of the adapter tube  50  can be sleeved with the connection port  61  of the output pipe  60 . Therefore, the adapter tube  50  can be connected to the pressure accumulator  40  and the output pipe  60  respectively. 
     In an embodiment of the present invention, a fixing groove  43  is provided on the output portion  41  of the pressure accumulator  40 , and at least one fixing hole  511  is oppositely provided at the end of the adapter tube  50  close to the first connecting end  51 . When the first connection end  51  of the adapter tube  50  is sleeved on the output portion  41  of the pressure accumulator  40 , the fixing hole  511  of the adapter tube  50  will overlap with the fixing groove  43  of the pressure accumulator  40 , and then a fixing piece  52  passes through the fixing hole  511  of the adapter tube  50  and is clamped in the fixing groove  43 , thereby the pressure accumulator  40  can be fixed on the adapter tube  50 . 
     The connection port  61  of the output pipe  60  is inserted into the second connection end  53  of the adapter tube  50 , and the connection port  61  of the output tube  60  is connected to the output part  41  of the pressure accumulator  40  through the adapter tube  50 . The connecting convex portion  65  of the output pipe  60  can be engaged in the engaging groove  55  of the adapter tube  50 , so that the output pipe  60  can be fixed to the adapter tube  50 . The connecting convex portion  65  and the engaging groove  55  may be one or more, and preferably two. 
     In an embodiment of the present invention, the connecting convex portion  65  of the output pipe  60  has a telescopic feature. When the output pipe  60  is inserted into the adapter tube  50 , the connecting convex portion  65  can shrink inwardly due to the extrusion of the inner wall of the adapter tube  50 . Once the connecting convex portion  65  reaches the position of the engaging groove  55  of the adapter tube  50 , the connecting convex portion  65  can protrude again because it is no longer pressed by the inner wall of the adapter tube  50 . 
     When the output pipe  60  is inserted into the adapter tube  50  from the second connection end  53 , the charging hole  69  of the output pipe  60  may be blocked by the adapter tube  50 , so a corresponding through hole  59  can be provided on the adapter tube  50 . When the connecting convex portion  65  of the output pipe  60  is engaged with the engaging groove  55  of the adapter tube  50 , the through hole  59  of the adapter tube  50  will be aligned with the charging hole  69  of the output pipe  60 . 
     Of course, in another embodiment of the present invention, the length of the adapter tube  50  can also be reduced, so that when the output pipe  60  is connected to the adapter tube  50 , the adapter tube  50  does not cover the charging hole  69  of the output pipe  60 . In this way, the through hole  59  does not need to be provided on the adapter tube  50 , as shown in  FIG.  5   . 
     In another embodiment of the present invention, the valve of the pressure accumulator  40  can be a solenoid valve  49 , which is electrically connected to a power supply device  48 , such as a battery, a mains socket or a power connection device. The plurality of valves of the solenoid valve  49  can control the high-pressure gas A entering and leaving the pressure accumulator  40 . The fluid supply device  80  may be a powder explosion, high voltage or high-pressure gas as a power source. As shown in the figure, the fluid supply device  80  includes a gas cylinder  81 , a pressure regulator  83  and a gas delivery pipe  85 . The gas delivery pipe  85  is connected to the gas cylinder  81  and the pressure accumulator  40 . The high-pressure gas A in the gas cylinder  81  can be input into the pressure accumulator  40  through the gas delivery pipe  85  by the pressure regulator  83 . 
     In another embodiment of the present invention, a first locking hole  56  is provided at a position adjacent to the first connecting end  51  of the adapter tube  50 , and a second locking hole  45  is provided at a corresponding position of the accumulator  40 . When the adapter tube  50  fixes the pressure accumulator  40 , a locking piece  58  passes through the first locking hole  56  and is locked to the second locking hole  45 , thereby improving the fixing of the pressure accumulator  40  to the adapter tube  50  for stability. 
     In another embodiment of the present invention, a hand-holding device  70  and at least one shooting button  71  are provided on the outer surface of the pressure accumulator  40 , so that the user can directly hold the needle-free injection system  30 . By pressing the shooting button  71 , the solenoid valve  49  is controlled, and the high-pressure gas A is guided into and out of the pressure accumulator  40 , and is shot from the ejection port  63  together with the delivery material to the target object. The hand-holding device  70  may be the outer housing of the pressure accumulator  40 . 
     Referring to  FIG.  5   , in an embodiment of the present invention, the engaging groove  55  can be designed to have a long guide groove or a hole groove that can extend to the second connecting end  53 , thereby allowing the connecting convex portion  65  enters and exits the transfer tube  50 . The output pipe  60  is rotated relative to the adapter tube  50 , so that the connecting convex portion  65  of the output pipe  60  is engaged with the engaging groove  55  of the adapter tube  50 . 
     Since the pressure regulator  83  of the fluid supply device  80  is relatively far from the pressure accumulator  40 , it is inconvenient for the user of the needle-free injection system  30  to adjust the input speed and/or the input quantity of the high-pressure gas A at any time during use. Therefore, a pressure trimmer  47  may be provided on the pressure accumulator  40 . The pressure trimmer  47  is provided on the pressure accumulator  40  and/or the hand-holding device  70 . The pressure trimmer  47  is convenient for the user to adjust the input speed and/or the input quantity of the high-pressure gas A at any time, thereby improving the convenience and safety of the operation. 
     Referring to  FIG.  6   , the hand-holding device  70  of the present invention can also be designed in the shape of a handle and fixed on the bottom side of the pressure accumulator  40 . Pressing the shooting button  71  of the hand-holding device  70  can control the high-pressure gas A to enter and exit the pressure accumulator  40 , and let the delivery material ( 99 ) pass through the ejection port  63  to shoot at the target object. In addition, in order to avoid the wrong injection of the delivery material ( 99 ) due to the wrong pressing of the shooting button  71 , the hand-holding device  70  can be provided with a safety switch  79 . Of course, the number of times or the number of seconds of pressing the shooting button  71  can also be used as a safety switch ( 79 ) for whether to shoot the delivery material ( 99 ), so that the safety switch  79  can be replaced. 
     The present invention includes a delivery device  97  that stores a delivery material  99 . The delivery device  97  is connected to the charging hole  69  of the output pipe  60 , and the delivery device  97  can send the delivery material  99  into the accommodating space  62  of the output pipe  60  through the charging hole  69 . 
     In an embodiment of the present invention, the pressure accumulator  40  is connected to a control panel  90 , and the control panel  90  has a display  91  and at least one control key  95 . The user can control the delivery time, delivery quantity or delivery times of the delivery material  99  entering the output pipe  60  through the control key  95 . On the other hand, the display  91  can display the calibration, the positioning, the inventory of the delivery material, the delivery time, the delivery quantity and/or the projection times of the delivery device  97 . The delivery device  97  can send the delivery material  99  into the accommodating space  62  of the output pipe  60  through the charging hole  69 . 
     The delivery material  99  suitable for the needle-free injection system  30  of the present invention can be a hypodermic filler, a tissue promoter, a botulinum toxin, a biological substance, a medicine, a care product, a polymer particle, or a radiesse. For example but not limited to a DNA, RNA, protein, cosmetic composition, minerals, virus particles,  Clostridium botulinum , hyaluronic acid, gelatinizer, collagen, vitamins, cellulose, fruit acids, transgenic organism, vaccine, essence, pearl, precious metals, pain-relieving genes and/or restore pigment. 
     Furthermore, referring to  FIGS.  7  and  8   , the control panel  90  of the present invention will be fixed on the outer surface of the pressure accumulator  40 . The delivery material can be placed in a material storage member  971  of a delivery device  97  and can be sent into the accommodating space  62  through a material delivery pipe  973  and the charging hole  69  of the output pipe  60 . When the high-pressure gas A is input from the connection port  61  and passes through the output pipe  60 , it will drive the delivery material in the accommodating space  62  to move toward the ejection port  63 , and leave the ejection port  63  to eject toward the target object (cell body). 
     The control panel  90  of the present invention can be fixed on the outer surface of the pressure accumulator  40  by a snap method, a magnetic attraction method or a socket method. As shown in this figure, the control panel  90  is secured to the top surface of the pressure accumulator  40 . The control panel  90  includes a display  91  and at least one control key  95 , and is connected to the delivery device  97  through a physical wired or a wireless transmission. The user of the needle-free injection system  30  can control the delivery device  97  through the control keys  95  on the control panel  90  to make the delivery device  97  perform a delivery procedure, such as but not limited to a start-up, calibration, positioning, delivery time, delivery number and/or delivery times. The display  91  can display the data of the delivery process. Since the control panel  90  of the present invention can be fixed on the outer surface of the housing of the needle-free injection system  30 , it can not only improve the convenience for the user to operate the needle-free injection system  30 , but also reduce its use space or storage space. 
     In an embodiment of the present invention, the control keys  95  and the display  91  of the control panel  90  are independent physical components. The content of the command issued by the control key  95  can also be displayed on the display  91  to facilitate the user&#39;s operation. 
     In an embodiment of the present invention, the control panel  90  is a touch panel. The control keys  95  may be integrated into the display  91 , and one or more image control keys  95  may be displayed on the display  91 . The user can press the image control key  95  on the display  91  of the touch panel  90  to issue a delivery command. Of course, the shooting button  71  of the hand-holding device  70  can also be integrated on the control panel  90  to become the image shooting button  71  on the display  91  of the touch panel  90 . 
     Referring to  FIG.  9   , the needle-free injection system  30  of the present invention can also be applied to a venturi type output tube  60 . Two ends of the venturi type output pipe  60  are respectively a connecting port  61  and an ejection port  63 , and there is an accommodating space  62  between the connecting port  61  and the ejecting port  63 . A reducing portion  601 , a throat portion  603  and a increasing portion  605  are respectively formed in the accommodating space  62 . Similarly, a delivery material can be put into the increasing portion  605  through a charging hole  69  of the venturi-shaped output pipe  60 . 
     Referring to  FIG.  10   , the pressure accumulator  40  of the needle-free injection system  30  can be directly fitted with the output tube  60  without using the adapter tube  50 . The connection port  61  of the output pipe  60  is sleeved on the output part  41  of the pressure accumulator  40 , so that the output pipe  60  is connected to the pressure accumulator  40 . The control panel  90  of the present invention can be fixed to the side surface of the housing of the pressure accumulator  40  by a magnetic attraction method, a screwing method, or a snapping method. 
     The delivery device  97  can be fixed on the top surface of the pressure accumulator  40 . The material storage member  971  thereof can store a delivery material  99 , and the material delivery pipe  973  is connected to the charging hole  69  of the output pipe  60 . In the embodiment shown in the figure, the material storage member  971  of the delivery device  97  is in the form of a syringe, the material delivery pipe  973  is in the form of a needle. The rear end of the material storage member  971  is driven by a driving device  975  (such as a motor). By driving back and forth, the delivery material  99  stored in the material storage member  971  can be sequentially injected into the material delivery pipe  973 , the charging hole  69  and the accommodating space  62  of the output pipe  60 . The material storage member  971  and material delivery pipe  973  can be withdrawn upwards to leave the pressure accumulator  40 , and the material storage member  971  can be refilled with the delivery material  99 . The driving device  975  is electrically connected to the power supply device  48 . 
     The delivery device  97  is electrically connected to the control panel  90 , and receives a delivery instruction from the control panel  90  to perform procedures such as calibration, positioning, and delivery. The delivery device  97  can drive the delivery material  99  into the output pipe  60  for delivery time, delivery quantity or delivery times. The control panel  90  can also integrate the shooting button  71  to control the high-pressure gas A entering and leaving the pressure accumulator  40  and the output pipe  60 . The shooting button  71  can be a physical button or an image shooting key on the touch panel ( 90 ). 
     Referring to  FIG.  11   , the hand-holding device  70  of the needle-free injection system  30  of the present invention can be designed as a handle structure, and is arranged on the bottom surface of the pressure accumulator  40  by a magnetic attraction element, a snap element or other fixing means. The control panel  90  is fixed on the rear surface of the pressure accumulator  40  and is electrically connected to the delivery device  97 . The control panel  90  may have a built-in battery, or be electrically connected to the power supply device  48 . If the control panel  90  is a detachable device, it can be fixed to the pressure accumulator  40 , the output pipe  60  or the outer casing of the hand-holding device  70  by a magnetic attraction. The control panel  90  can transmit the delivery instruction to the delivery device  97  via wireless communication. 
     Referring to  FIG.  12   , the control panel  90  can be a portable control panel, such as but not limited to a mobile phone, a tablet computer or a digital media player (eg, iPod). The portable control panel  90  has a display  91 , a wireless transmitter  93  and/or a control key  95 . The control keys  95  may also be touch panel keys provided in the display  91 . The wireless transmitter  93  can be a wireless network (wifi), a bluetooth or a ZigBee. The delivery instruction may be wirelessly transmitted to the delivery device  97  via the wireless transmitter  93 . In this way, the user can directly use the user&#39;s mobile phone, tablet computer or digital media player as the control panel  90 , which not only obtains the convenience of using the needle-free injection system  30 , but also saves the cost of setting up the control panel  90 . 
     In an embodiment of the present invention, one of the control keys  95  can also be designed as a shooting button (key)  71 , and the firing command is transmitted to the pressure accumulator  40  through the wireless transmitter  93  of the control panel  90 , and the high-pressure gas A enters and exits the pressure accumulator  40 , the output pipe  60 , and the delivery material  99  are ejected toward a target object (eg, a cell body) through the ejection port  63 , thereby improving the convenience of use of the needle-free injection system  30 . Of course, in this embodiment, the pressure accumulator  40  is also provided with a corresponding signal receiver  44 , which can receive the firing command from the control panel  90  and/or the control key  95  in a wired or wireless manner. 
     In an embodiment of the present invention, the outer surface of the hand-holding device  70  or the outer surface of the pressure accumulator  40  is provided with a panel holder  75 , such as but not limited to a magnet, a devil felt, a set of parts (such as leather cases) and/or an engaging part (such as buttons, hooks), etc. The portable control panel  90  can be fixed on the hand-holding device  70  or the pressure accumulator  40  through the panel holder  75 , thereby improving the convenience for the user to operate. 
     The needle-free injection system  30  of the present invention can control the delivery material  99  to be injected into a target object through the control panel  90  and/or the fluid supply device  80 , and can also control the depth of the delivery material  99  entering the target. For example, the delivery material  99  can be injected directly into the cell body or deep within the skin. Of course, it is also possible to control the delivery material  99  to only reach the skin surface, which can be the same as the external application effect of a general external application patch, and then absorb the diffusion effect or therapeutic effect of the delivery material  99  through the skin. 
     In addition, referring to  FIG.  13   , the needle-free injection system of the present invention can be applied to a proliferative device. As shown in the figure, the needle-free injection system  30  of the present invention mainly includes a pressure accumulator  40 , an output pipe  60 , a delivery device  97 , a hand-holding device  70  and a power supply device  80 . The pressure accumulator  40  has an output portion  41 , a pressure accumulating chamber  42  and a power controller  46 . The output portion  41  is located at the front end of the pressure accumulating chamber  42 , and the power controller  46  is located in the pressure accumulating chamber  42 . The pressure accumulator  40  is connected to the power supply device  80 , and the power supply device  80  provides a power source A. The power source A can be a high-pressure gas, a compressed gas, a gunpowder detonating pressure and/or a high-pressure discharge. This figure takes a high-pressure gas as an example. The high-pressure gas A is input to the pressure accumulator  40  from the power supply device  80 , so that the gas pressure in the pressure accumulator  40  is greater than that of the outside world, for example, greater than atmospheric pressure. The power controller  46  can control the power source A to enter and exit the pressure accumulator  40 , and transmit the power source A to the output pipe  60  through the output portion  41 . 
     The delivery device  97  includes a driving device  975 , a material storage member  971  and a material delivery pipe  973 , all of which can be fixed to the top surface of the pressure accumulator  40 . A delivery material  99 , such as a proliferative agent in this embodiment, can be placed in the material storage member  971 , and the driving device  975  can move back and forth to push the delivery material  99  through the delivery pipe  973  and the charging hole  69  to put into the accommodating space  62  of the output pipe  60 . 
     In an embodiment of the present invention, the material storage member  971  can be a syringe, the material delivery pipe  973  at the front end thereof can be connected to the charging hole  69  of the output pipe  60 . The push rod at the rear end of the material storage member  971  contacts a driving device  975 . The driving device  975  is a motor assembly that can move back and forth. When the driving device  975  is retracted, the material storage member  971  and/or the material delivery pipe  973  can be moved out and away from the delivery device  97 , so that the storage member  971  and/or the proliferative agent  99  can be replaced. Conversely, when the driving device  975  moves forward, the push rod can be pushed forward, and the delivery material (eg, a proliferative agent)  99  placed in the material storage member  971  can be pushed into the accommodating space  62 . 
     When the high-pressure gas A is input from the connection port  61  and passes through the output pipe  60 , it will drive the delivery material (eg, a proliferative agent)  99  in the accommodating space  62  to move toward the ejection port  63 , and is ejected from the ejection port  63  to a target object, such as tendons, ligaments, dermis, joint capsules, or cell bodies of an organism. The above-mentioned structure of the output pipe  60  is only a specific embodiment of the present invention, and is not intended to limit the scope of the right of the present invention. 
     In an embodiment of the present invention, a partition unit  67  is provided in the accommodating space  62  of the output pipe  60 . The dividing unit  67  may divide the accommodating space  62  into two connected spaces. The output pipe  60  of this embodiment is a jet engine type output pipe, which can accelerate the speed of the power source A input from the connection port  61  and ejected from the ejection port  63 . 
     In an embodiment of the present invention, the power controller  46  is a solenoid valve, and the pressure accumulating chamber  42  can be designed as an outer casing of the solenoid valve. In other words, the power controller  46  in the pressure accumulator  40  can be integrated with the pressure accumulating chamber  42 , and the output portion  41  is located at the front end of the power controller  46 . The driving device  975  and the power controller  46  can be electrically connected to a power supply device  48 . The power supply device  48  can be a battery, a mains socket or a power connection device. 
     Referring to  FIG.  14   , a delivery material (eg, a proliferative agent)  99  will be placed in a material storage member  971  of the delivery device  97 . The operator can set the delivery command of the delivery device  97  through the control panel  90 , including but not limited to activation, calibration, positioning, delivery time, delivery quantity and/or delivery times. The power supply device  80  continuously provides a power A to the pressure accumulator  40 . The operator can hold the hand-holding device  70 , align the ejection port  63  of the output pipe  60  with the target object  96 , and then press the shooting button  71  to control the power A and the proliferative agent  99  stored in the accommodating space  62  is injected into the target object  96 , so that the proliferative agent  99  can be injected into the target object  96 . 
     The needle-free injection system  30  of the present invention can change the position of the target object  96  to be injected continuously, in stages, and at any time. Therefore, the needle-free injection system  30  can abandon the injection needle of the traditional acupuncture method, and can easily deliver the delivery material (eg, proliferative agent)  99  is injected into the multiple target object  96 , which not only improves the convenience of the operator during injection, but also reduces the discomfort and risk of the patient being punctured by the injection needle. The needle-free injection system  30  can further enhance the therapeutic effect of the delivery material  99 . 
     The delivery material (eg, proliferative agent)  99  to which the needle-free injection system  30  of the present invention is applicable can be a cellular preparation, an osmotic shock, an irritant, or a chemotactic agent. More specifically, the proliferative agent  99  can be a high concentration platelet rich plasma (PRP), stem cells, glucose, glycerol, zinc sulfate, phenol, tannin, guaiacol, pumice, cod liver oleic acid, extracts, ozone and/or vitamins. The target object  96  to be hit is in a tendon, ligament, dermis, joint capsule, cell body, scalp tissue, skin and other tissues. It can also be repaired for various spinal joints or skeletal muscles and other painful parts. For sports injuries, Osteoarthritis, Shoulder and Neck Pain, Fifty Shoulders, Tennis Elbow, Elbow Pain, Wrist Pain, Knee Pain, Ankle, Spine Pain, Lower Back Pain, Plantar Fasciitis, Meniscus Injury, Cruciate Ligament Injury Rotator Tendon It has significant therapeutic effects on inflammation, tendinopathy, chronic pain, skin scars, firming and smoothing of skin, hyperplasia of scalp hair follicles, and prevention of hair loss. 
     The delivery material (eg, proliferative agent)  99  to which the needle-free injection system  30  of the present invention is applicable can be a cellular preparation, an osmotic shock, an irritant, or a chemotactic agent. More specifically, the proliferative agent  99  can be a high concentration platelet rich plasma (PRP), stem cells, glucose, glycerol, zinc sulfate, phenol, tannin, guaiacol, pumice, cod liver oleic acid, extract. substances, ozone and/or vitamins. The target  99  to be hit is a tendon, ligament, dermis, joint capsule, cell body, scalp tissue, skin, vertebral joint, skeletal muscle, etc. It is also suitable for sports injuries, degenerative arthritis, shoulder and neck pain, fifty shoulders, tennis elbow, elbow pain, wrist pain, knee pain, ankle pain, spine pain, lower back pain, plantar fasciitis, meniscus injury, cruciate ligament injury, rotator tendonitis, tendinopathy, chronic pain, skin scars, firming skin smooth, scalp hair follicle hyperplasia, preventing hair loss, etc. have significant therapeutic effects. 
     The needle-free injection system  30  of the present invention has a particularly significant therapeutic effect on platelet rich plasma (PRP). Of course, the collection of the delivery material (eg, proliferative agent)  99  still needs to go through procedures such as blood drawing of the patient body, blood separation by centrifuge, extraction of high-concentration platelet plasma is placed in the material storage member  971  of the delivery device  97 , rather than a traditional injection needle, so the subsequent injection methods are completely different, and the effects after injection are also different. 
     Finally, referring to  FIG.  15   , the needle-free injection system  30  of the present invention can be applied to a venturi-type output tube  60 . The two ends of the venturi-shaped output pipe  60  are respectively a connecting port  61  and a jetting port  63 , and a partition unit is arranged in the accommodating space  62 , including a throat portion  603 , the two ends of the throat portion  603  are respectively a reducing portion  601  and a increasing portion  605 . A delivery material  99  can be fed into the increasing portion  605  through a charging hole  69  of the venturi-shaped output tube  60 . 
     The above disclosure is only the preferred embodiment of the present disclosure, and not used for limiting the scope of the present disclosure. All equivalent variations and modifications on the basis of shapes, structures, features and spirits described in claims of the present disclosure should be included in the claims of the present disclosure.