Patent Publication Number: US-2005143623-A1

Title: Medical capsule apparatus

Description:
This application claims the benefit of Japanese Application No. 2003-431383 filed on Dec. 25, 2003, the contents of which are incorporated by this reference.  
     BACKGROUND OF THE INVENTION  
      1. Field of the Invention  
      The present invention relates to a medical capsule apparatus, and more particularly, to a medical capsule apparatus having observing means that observes the state of the body cavity in a substantially-capsule-shaped casing as a whole, with which a desired portion in the body cavity is observed and a medical drug or the like is sprayed.  
      2. Description of the Related Art  
      One conventional endoscope apparatus comprises a tube inserting portion having an image pick-up device at the distal end thereof, an operating portion continuously-arranged to the inserting portion, and various devices such as an image processing device, a display unit, and a light source device which are connected to the operating portion. In the examination of the body cavity or the like, the inserting portion is inserted into the body cavity from the mouth of an examinee and a desired portion of the body cavity is observed. The conventional endoscope apparatus described as above is put into practical use and is widely used. However, the conventional endoscope apparatus described as above has a limit of the length of the inserting portion that is inserted in the body cavity. Consequently, the range of the observation or examination is limited.  
      Recently, a compact endoscope for accommodating image pick-up means (observing means) including an image pick-up optical system, illuminating means, communication means, power receiving means and a power supply, for example, in a capsule casing is variously suggested. That is, a medical capsule apparatus called a capsule endoscope is variously suggested.  
      Further, Japanese Unexamined Patent Application Publication No. 2-19140 discloses another conventional medical capsule apparatus in which a medical drug is accommodated in a capsule, an examinee swallows a capsule apparatus into the body cavity, then, the medical drug accommodated in the capsule is arbitrarily discharged out of the capsule by driving means using the electric control operation.  
      In the conventional medical capsule apparatus disclosed in Japanese Unexamined Patent Application Publication No. 2-19140, a mechanochemical substance which expands by receiving a voltage application or a change of a pH level and then increases in volume is used, thereby discharging the medical drug accommodated in the capsule out of the capsule.  
      Further, in the observation of the body cavity using the one conventional medical capsule device having the observing means, it is excessively convenient to perform predetermined treatment such as an operation for spraying the medical drug to a found lesion portion in the body cavity of the examinee. The medical drug sprayed in this case may be a curing medical drug or a marking agent for specifying the lesion portion.  
      Thus, the medical capsule apparatus observes the body cavity and simultaneously executes treatment on the desired portion. Further, in the detailed examination using a normal endoscope after the examination using the medical capsule apparatus, the operation for re-finding the lesion portion as a target of the endoscope examination is easy and the treatment is performed fast without fail.  
      In view of the form of the capsule main body of the conventional medical capsule endoscopes, observing means for observing the body cavity and a mechanism for accommodating and discharging the medical drug are integrally structured.  
      However, with the above-mentioned structure, the medical capsule apparatus must be provided corresponding to every kind of the used medical drug. Therefore, the structure has a problem that a user must prepare medical capsule apparatuses varied depending on any medical drugs which may be used.  
     SUMMARY OF THE INVENTION  
      According to the present invention, a medical capsule apparatus put into the body cavity includes at least a main body unit having a function for observing the body cavity, and a medical drug unit having a function for accommodating and discharging the medical drug. The main body unit and the medical drug unit are freely connected and separated.  
      The advantages of the present invention will be obvious by the following detailed description. 
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS  
       FIG. 1  is a block diagram schematically showing the internal structure of a medical capsule apparatus according to a first embodiment of the present invention;  
       FIG. 2  is a conceptual diagram showing a separating state of a main body unit and a medical drug unit in the medical capsule apparatus according to the first embodiment;  
       FIG. 3  is a conceptual diagram showing a solving state of a soluble film when the main body unit is connected to the medical drug unit in the medical capsule apparatus shown in  FIG. 1  and the main body unit and the medical drug unit are put in the body cavity;  
       FIG. 4  is a conceptual diagram showing a state of discharging a medical drug from the medical drug unit by operating a magnetic-force generating portion of the main body unit in the medical capsule apparatus shown in  FIG. 1 ;  
       FIG. 5  is a diagram schematically showing the arrangement of internal members in a medical capsule apparatus according to a second embodiment of the present invention; and  
       FIG. 6  is a cross-sectional view along VI-VI-line in  FIG. 5 . 
    
    
     DESCRIPTION OF THE PREFERRED EMBODIMENTS  
      Hereinbelow, a description is given of embodiments of the present invention with reference to the drawings.  
       FIG. 1  is a block diagram schematically showing the internal structure of a medical capsule apparatus according to a first embodiment of the present invention. Referring to  FIG. 1 , the cross section of the medical capsule apparatus is shown, thus showing the internal structure.  
      Referring to  FIG. 1 , a medical capsule apparatus (hereinafter, referred to as a capsule apparatus)  1  according to the first embodiment comprises: a main body unit  10  having the arrangement of various components such as observing means for observing the body cavity in a casing; and a medical drug unit  20  having a mechanism which accommodates and discharges a medical drug.  
       FIG. 1  shows a connecting state of the main body unit  10  and the medical drug unit  20 . In the connecting state shown in  FIG. 1 , the external shape of the capsule apparatus  1  is substantially capsule-shaped as a whole.  
      Separately from the main body unit  10  and the medical drug unit  20 , the capsule apparatus  1  comprises an external control device (not shown) comprising control means which externally controls the main body unit  10 .  
      The main body unit  10  comprises a main-body-unit exterior case  11  serving an exterior member for watertightly sealing the main body unit  10  and various components arranged in the main-body-unit exterior case  11 . For example, the main body unit  10  comprises in the main-body-unit exterior case  11 : an image pick-up unit serving as observing means comprising an illumination  13  serving as illuminating means and a light source, optical lenses  15  serving as an optical system having a plurality of optical devices, a lens barrel  15   a  which holds the optical lenses  15 , a solid-state image pick-up device  14  which generates an image signal of a subject, and a signal processing portion  16  serving as signal processing means which processes an output signal from the solid-state image pick-up device  14 ; a circuit substrate  12  having the signal processing portion  16 , the illumination  13 , an electric circuit for controlling the driving operation of the signal processing portion  16  and the illumination  13 , and a control circuit which systematically controls electric circuits in the capsule apparatus  1 ; a radio receiving/sending portion  17  serving as communication means which receives an output signal from the signal processing portion  16  and receives/sends the signal between the main body unit  10  and the external control device; a battery  18  which supplies power to the electric components in the capsule apparatus  1 ; medical drug discharge control means having a magnetic-force generating portion  19   b  which controls a signal for generating the magnetic force and a magnetic-force control portion  19   a  which controls the driving operation of the magnetic-force generating portion  19   b , the magnetic force generated from the magnetic-force generating portion  19   b , and the discharge operation of a medical drug  22 ; a flexible printed circuit (FPC) board  12   a  which electrically connects the circuit substrate  12  to the radio receiving/sending portion  17  or the battery  18  and the magnetic-force generating portion  19   b  to the magnetic-force control portion  19   a ; and the like.  
      The main-body-unit exterior case  11  contains a rigid member such as resin, and comprises: a transparent window portion  11   a  which covers and protects the front portion of the main body unit  10  in the capsule apparatus  1  and through which illuminated beams outputted from the illumination  13  or beams incident on the optical lenses  15  are passed; and a main body portion  11   b  which comprises a main portion of the main-body-unit exterior case  11  with internal components and externally covers and protects the internal components.  
      Among the components of the image pick-up unit serving as the observing means, the optical lenses  15  comprise a plurality of lenses as mentioned above. The optical lenses  15  are held by the lens barrel  15   a.    
      On the rear side along the optical axis of the optical lenses  15  held by the lens barrel  15   a , the circuit substrate  12  is arranged at a predetermined position perpendicularly to the optical axis. The solid-state image pick-up device  14  is mounted on the circuit substrate  12 , having the light receiving surface thereof in the front-surface direction. The solid-state image pick-up device  14  comprises an image pick-up device such as a CCD or a CMOS which receives an optical image of the subject that passes through the optical lenses  15  and is formed and which performs photoelectrical converting processing.  
      Mounted on the circuit substrate  12  is an electric circuit comprising a plurality of electric parts which drive the solid-state image pick-up device  14  and perform predetermined signal processing. Thus, the optical image of the subject formed by the optical lenses  15  is formed onto the light receiving surface of the solid-state image pick-up device  14 , predetermined photoelectrical converting processing is performed, and a predetermined image signal is generated.  
      The illumination  13  is a light source such as an LED (light emitting device) or an organic EL which illuminates the subject such as the digestive organ in the body cavity. The illumination  13  is mounted on the circuit substrate  12  so as to illuminate the subject on the front side of the capsule apparatus  1 .  
      The illumination  13  illuminates the subject and the illuminating beams are reflected by the subject. Then, the reflected beams are condensed by the optical lenses  15 . After the condensed beams pass through the optical lenses  15 , the optical image of the subject is formed onto the light receiving surface of the solid-state image pick-up device  14 .  
      The solid-state image pick-up device  14  receives the optical image of the subject formed by the optical lenses  15 , performs the signal processing such as the predetermined photoelectrical converting processing, and generates an electric signal (image signal) corresponding to the optical image of the subject.  
      The image signal outputted from the solid-state image pick-up device  14  is subjected to various signal processing (including image signal processing and communication processing) in the signal processing portion  16 . Thereafter, the image signal is outputted to the radio receiving/sending portion  17 .  
      As mentioned above, the medical-drug discharge control means comprises the magnetic-force generating portion  19   b  and the magnetic-force control portion  19   a , and forms a mechanism for externally discharging the medical drug  22  accommodated in a medical drug unit  20  which will be described later. In this case, the magnetic-force control portion  19   a  receives a predetermined radio signal from a radio sending device externally-arranged to the body cavity, and controls the magnetic force of the magnetic-force generating portion  19   b  based on the received signal (which will be described in detail later).  
      The medical drug unit  20  comprises: a medical-drug-unit exterior case  21  which contains a rigid member such as resin and has a space for filling the medical drug  22  therein; the medical drug  22  which is filled in the medical-drug-unit exterior case  21 ; a magnetic-force absorbing portion  23  which absorbs the magnetic force; a spray nozzle  24  which externally discharges and sprays the medical drug  22  filled in the medical-drug-unit exterior case  21 ; a soluble film  25  serving as spray nozzle opening/closing means which is at one end of the spray nozzle  24  and is arranged to close and watertightly seal a hole portion  21   a  of the medical-drug-unit exterior case  21 .  
      The used medical drug  22  is a medical drug for curing, a marking agent which specifies the lesion portion, or the like.  
      The magnetic-force absorbing portion  23  contains a plate member which absorbs magnetic force. Further, the magnetic-force absorbing portion  23  is arranged so as to be moved in parallel with the absorbing direction of the magnetic-force generating portion  19   b  in the medical drug unit  20  upon generating the magnetic force from the magnetic-force generating portion  19   b  by the magnetic-force control portion  19   a  of the main body unit  10 .  
      The spray nozzle  24  comprises a hollow tube member which is communicated with the hole portion  21   a  formed substantially in the center of one side surface of the medical-drug-unit exterior case  21  and which is arranged toward the inside of the medical-drug-unit exterior case  21 . The spray nozzle  24  is arranged to externally discharge the medical drug  22  filled in the medical-drug-unit exterior case  21 .  
      That is, the magnetic-force control portion  19   a  of the main body unit  10  generates the magnetic force from the magnetic-force generating portion  19   b  and then the magnetic-force absorbing portion  23  of the medical drug unit  20  is moved in parallel with the direction for absorbing the magnetic-force absorbing portion  23  of the medical drug unit  20  to the magnetic-force generating portion  19   b . Then, the medical drug  22  filled in the medical drug unit  20  is pressed. Therefore, the medical drug  22  is externally discharged out of the medical-drug-unit exterior case  21  via the spray nozzle  24 .  
      The soluble film  25  contains a thin-film member made of a soluble component such as gelatin in the body cavity. The hole portion  21   a  of the medical-drug-unit exterior case  21  is watertightly closed by using the soluble film  25 . Thus, the soluble film  25  prevents the leakage of the medical drug  22  from the medical-drug-unit exterior case  21  and the invasion of molds and the like in the medical-drug-unit exterior case  21 .  
      Upon using the capsule apparatus  1 , that is, under the environment in the body cavity, the soluble film  25  is solved. Therefore, when the capsule apparatus  1  reaches a desired portion in the body cavity and then the medical drug  22  is discharged, the closed state of the hole portion  21   a  of the medical-drug-unit exterior case  21  is reset and the medical drug  22  is easily discharged.  
      The main body unit  10  and the medical drug unit  20  with the above-mentioned structure are connected by mechanical connecting means such as a screwing tool or a screw stop tool. Although not shown, a male screw is formed on the outer circumferential surface side at one end (on the arranging side of the magnetic-force generating portion  19   b ) of the main-body-unit exterior case  11  in the main body unit  10 . A female screw is formed near another end (on the opposite side of the formed side of the hole portion  21   a ) of the medical-drug-unit exterior case  21  in the medical drug unit  20 . Further, the main body unit  10  and the medical drug unit  20  are connected by the screw connection or the like.  
      Hereinbelow, a description is given of the operation of the capsule apparatus  1  with the above-mentioned structure according to the first embodiment.  
       FIG. 2  is a conceptual diagram showing the separating state of the main body unit  10  and the medical drug unit  20  in the capsule apparatus  1 .  FIG. 3  is a conceptual diagram showing the state of solving the soluble film  25  when the main body unit  10  is connected to the medical drug unit  20  in the medical capsule apparatus  1  shown in  FIG. 1  and the main body unit  10  and the medical drug unit  20  are put in the body cavity.  FIG. 4  is a conceptual diagram showing the state of discharging the medical drug  22  from the medical drug unit  20  by operating the magnetic-force generating portion  19   b  of the main body unit  10  in the medical capsule apparatus  1  shown in  FIG. 1 . The structure of the capsule apparatus  1  is simply shown in FIGS.  2  to  4 , and the internal structure is partly omitted.  
      Referring to  FIG. 2 , in the capsule apparatus  1  before use, the main body unit  10  and the medical drug unit  20  are separated from each other. In using the capsule apparatus  1 , the medical drug unit  20  corresponding to the application is selected from a plurality of medical drug units  20  containing different kinds of medical drug, and the selected medical drug unit  20  is mechanically connected to the main body unit  10 . Then, the state shown in  FIG. 1  is obtained.  
      The examinee swallows the capsule apparatus  1  in which the main body unit  10  and the medical drug unit  20  are connected. Thus, the capsule apparatus  1  is moved in the body cavity of the examinee by the peristaltic motion. In this case, the image pick-up unit operates on the main body unit  10  side and the state of the body cavity is observed.  
      That is, while the capsule apparatus  1  is moved in the body cavity, the illumination  13  illuminates the body cavity. In this case, the optical lenses  15  form the optical image of the body cavity onto the light receiving surface of the solid-state image pick-up device  14 . The solid-state image pick-up device  14  receives the optical image, photoelectrically converts the image, generates an electric signal, and outputs the generated signal to the signal processing portion  16 . The signal processing portion  16  performs predetermined signal processing and then outputs the processed signal to the radio receiving/sending portion  17 . The radio receiving/sending portion  17  communicates the input image signal by predetermined radio waves and sends the signal to the external control device (not shown). The external control device which receives the sent signal performs predetermined signal processing and outputs the processed signal to a monitor device (not shown) or a recording device. As a consequence, the image of the body cavity is displayed on the monitor device and the recording device records the image signal indicating the image.  
      After the examinee swallows the capsule apparatus  1  and the capsule apparatus  1  is put in the body cavity, the soluble film  25  arranged to the medical drug unit  20  of the capsule apparatus  1  starts to gradually be solved under the environment of the body cavity and then reaches the state shown in  FIG. 3 . In this state, the hole portion  21   a  of the medical-drug-unit exterior case  21  in the medical drug unit  20  is opened.  
      An operator of the capsule apparatus  1  observes the image of the body cavity displayed on the monitor device and simultaneously waits until the capsule apparatus  1  reaches a desired portion (lesion portion) in the body cavity. When the capsule apparatus  1  reaches the desired portion in the body cavity, the operator executes a predetermined operation of the external control device, and sends a predetermined control signal to the main body unit  10 . The control signal generated in this case is an instructing signal for controlling the driving operation of the magnetic-force generating portion  19   b  via the magnetic-force control portion  19   a  and for generating predetermined magnetic force. The instructing signal is communicated to the magnetic-force control portion  19   a  via the radio receiving/sending portion  17 . Then, the magnetic-force control portion  19   a  controls the driving operation of the magnetic-force generating portion  19   b , and thus generates the predetermined magnetic force from the magnetic-force generating portion  19   b . The generated magnetic force acts on the magnetic-force absorbing portion  23  of the medical drug unit  20  and the magnetic-force absorbing portion  23  starts to be moved in the direction (X direction shown in  FIG. 3 ) for absorption to the magnetic-force generating portion  19   b . In accordance therewith, referring to  FIG. 4 , the medical drug  22  filled in the medical-drug-unit exterior case  21  is externally sprayed from the hole portion  21   a  via the spray nozzle  24 . As a consequence, the medical drug  22  is adhered to a desired portion of the lesion portion in the body cavity of the examinee.  
      After that, the capsule apparatus  1  continuously moves by the peristaltic motion in the body cavity and then is naturally discharged out of the body.  
      As mentioned above, according to the first embodiment, the main body unit  10  including the image pick-up unit for observing the body cavity and the medical drug unit  20  for accommodating the medical drug  22  therein and arbitrarily discharging it are separately structured, and are connected by easy means. Thus, the medical drug unit  20  is selected in accordance with the application and the selected medical drug unit  20  is just connected to the main body unit  10 , thereby conveniently structuring the capsule apparatus  1  suitable to the case.  
      The medical drug unit  20  is just varied depending on the kinds of the medical drug  22  filled therein. The number of the main body units  10  comprising a relatively expensive component need not be prepared the same number as the medical drug units  20 , thereby reducing the management costs.  
      Further, the main body unit  10  can be reused and therefore this contributes to the further reduction in management costs.  
      The structure of the medical drug unit  20  is simplified, and the medical drug unit  20  is manufactured as a single unit. Therefore, a device manufacturer of the main body unit  10  can be different from that of the medical drug unit  20 . Since many medical drug manufacturers share the manufacture of the medical drug unit  20 , this contributes to the reduction in manufacturing costs.  
      According to the first embodiment, the main body unit  10  in the capsule apparatus  1  includes the battery  18 , and the battery  18  supplies the power to the internal circuits in the main body unit  10 . However, the present invention is not limited to this.  
      For example, among the internal components of the main body unit  10  according to the first embodiment, in place of the radio receiving/sending portion  17  and the battery  18 , a radio power feed portion for receiving and sending the control signal and supplying the power by external radio means may be arranged. With the above-mentioned structure, the same advantages as those according to the first embodiment are obtained.  
      Positional information in the body cavity on the lesion portion is grasped by the diagnosis result obtained in advance by another means. In view of this, the main body unit  10  in the capsule apparatus  1  according to the first embodiment may comprise predetermined position detecting means which detects the position of the capsule apparatus  1  inserted in the body cavity, in place of the observing means such as the image pick-up unit that is relatively expensive. The above-mentioned position detecting means is used together with the positional information on the lesion portion that is grasped in advance and then the same advantages as those according to the first embodiment are obtained while realizing the reduction in total costs.  
      Next, according to a second embodiment, a description is given of a case in which the main body unit side of the capsule apparatus comprises in-body information detecting means (in-body sensing unit) which detects the state in the body, in place of the observing means.  
       FIG. 5  is a schematic diagram conceptually showing the arrangement of internal components of a medical capsule apparatus according to the second embodiment of the present invention.  FIG. 6  is a cross-sectional view along VI-VI-line in  FIG. 5 .  
      Referring to  FIG. 5 , a capsule apparatus  1 A according to the second embodiment comprises: a main body unit  10 A having the arrangement of various components such as an in-body sensing unit serving as the in-body information detecting means for detecting a desired portion in the body cavity; and a medical drug unit  20 A (also refer to  FIG. 6 ) having a mechanism for accommodating a plurality of medical drugs and discharging the medical drugs.  
      Incidentally,  FIG. 5  shows the connecting state of the main body unit  10 A and the medical drug unit  20 A. In the connecting state shown in  FIG. 5 , the outer shape is substantially capsule-shaped as a whole.  
      In the capsule apparatus  1 A, similarly to the first embodiment, independently of the main body unit  10 A and medical drug unit  20 A, the capsule apparatus  1 A further comprises an external control device (not shown) comprising control means for externally controlling the main body unit  10 A.  
      The main body unit  10 A comprises: a main-body-unit exterior case  11 A serving as an exterior member for watertightly sealing the inside; and various components arranged in the main-body-unit exterior case  11 A. For example the main body unit  10 A comprises in the main-body-unit exterior case  11 A: an in-body sending unit, serving as the in-body information detecting means comprising a sensor  8  functioning as observing means for observing the state in the body cavity by detecting the state of the body cavity and a signal processing portion  16 A serving as signal processing means for processing an output signal from the sensor  8 ; a circuit substrate  12 A having a control circuit for entirely controlling the signal processing portion  16 A, the sensor  8 , an electric circuit for controlling the driving operation of the signal processing portion  16 A and the sensor  8 , and an internal electric circuit of the capsule apparatus  1 A; a radio power feed portion  9 , serving as communication means which receives a signal outputted form the signal processing portion  16 A and receives/sends the signal between the main body unit  10 A and the external control device, which feeds, by predetermined radio means, power from an external power supply and which supplies the power to an electric component in the capsule apparatus  1 A; medical drug discharge control means comprising the magnetic-force generating portion  19   b  for controlling a signal for generating the magnetic force and the magnetic-force control portion  19   a  for controlling the driving operation of the magnetic-force generating portion  19   b ; the flexible printed circuit (FPC) board  12   a  which electrically connects the circuit substrate  12 A to the radio power feed portion  9 , the magnetic-force control portion  19   a , and the magnetic-force generating portion  19   b ; and the like.  
      The main-body-unit exterior case  11 A contains a rigid member such as resin, and the internal component in the main body unit  10 A of the capsule apparatus  1 A is covered and is protected.  
      The sensor  8  has a communicating portion  8   a  which is partly communicated with the outside of the main-body-unit exterior case  11 A. Thus, the state of the body cavity serving as the external state of the main-body-unit exterior case  11 A is detected. The communicating portion  8   a  is unnecessary depending on the type of the sensor  8 . For example, a detecting sensor using light does not need the communicating portion  8   a , and may have a window portion containing transparent resin at a predetermined portion of the main-body-unit exterior case  11 A corresponding to the detecting device of the sensor  8 .  
      The sensor  8  for detecting and observing the state of the body cavity (also referred to as in-body information) may be a pH sensor, a temperature sensor, a pressure sensor, or a detecting sensor of the blood or tumor marker.  
      The radio power feed portion  9  comprises the same functions as those of the radio receiving/sending portion according to the first embodiment, that is, a portion having a function for receiving an output signal from the sensor  8 , sending the received signal to the external control device, and receiving the control signal from the external control device, and a portion having a function for supplying the power from the external power to a battery portion for feeding and charging the power from the external power supply by predetermined radio means, an electric member of the capsule apparatus  1 A, the sensor  8 , the signal processing portion  16 A, and the medical-drug discharge control means.  
      The magnetic-force control portion  19   a  and the magnetic-force generating portion  19   b  forming the medical-drug discharge control means are components having the same functions as those according to the first embodiment.  
      The medical drug unit  20 A according to the second embodiment comprises: a medical-drug-unit exterior case  21 A which contains a rigid member such as resin and has a space for filling the medical drug  22  therein; the medical drug  22  which is filled in the medical-drug-unit exterior case  21 A; a magnetic-force absorbing portion  23 A which absorbs the magnetic force; a spray nozzle  24 A which externally discharges and sprays the medical drug  22  filled in the medical-drug-unit exterior case  21 A; a soluble film  25  which is at one end of the spray nozzle  24 A and is arranged to close and watertightly seal the hole portion  21   a  of the medical-drug-unit exterior case  21 A.  
      In the internal space of the medical-drug-unit exterior case  21 A, a plurality of spaces are formed by partitions  21 Aa (refer to  FIG. 6 ). In the individual spaces, different medical drugs  22  or the same type of the medical drug  22  is filled. Further, in the individual spaces, the magnetic-force absorbing portion  23 A and the spray nozzle  24 A are arranged. Furthermore, the holes  21   a  are pierced in the individual spaces. The hole portions  21   a  are closed by the soluble film  25 . Thus, in the single medical drug unit  20 A, a plurality of kinds of medical drugs  22  are simultaneously filled.  
      The magnetic-force absorbing portions  23 A arbitrarily operate by controlling the driving operation of the magnetic-force generating portion  19   b  by the magnetic-force control portion  19   a  of the main body unit  10 A. Therefore, a plurality of medical drugs  22  are discharged at varied timings.  
      Other structures are the same as those according to the first embodiment. Referring to  FIG. 5 , the components having the same numeral as those according to the first embodiment have the same functions.  
      The operation of the capsule apparatus  1 A with the above-mentioned structure according to the second embodiment is substantially the same as that according to the first embodiment. However, since the in-body sensing unit is arranged as the in-body information detecting means in place of the image pick-up unit as the observing means according to the first embodiment, the operation of the in-body sensing unit will mainly be described.  
      Similarly to the first embodiment, the capsule apparatus  1 A is formed by combining and connecting the medical drug unit  20 A in which the medical drug  22  is filled in accordance with the application and the main body unit  10 A having the sensor  8  in accordance with the application.  
      The examinee swallows the capsule apparatus  1 A and then the soluble film  25  is solved in the body cavity similarly to the first embodiment. Then, the hole portions  21   a  of the medical-drug-unit exterior case  21 A are opened.  
      Upon moving the capsule apparatus  1 A in the body cavity, the capsule apparatus  1 A is moved while the sensor  8  detects the state of the body cavity via the communicating portion  8   a . An output of the sensor  8  is transmitted to the radio power feed portion  9  via the signal processing portion  16 A and is sent to the external control device via the radio power feed portion  9 . Consequently, the operator continuously recognizes the state of the body cavity.  
      The capsule apparatus  1 A is monitored while the detecting result of the sensor  8  is observed. When the capsule apparatus  1 A reaches a desired portion, the operator performs predetermined operation of the external control device and a predetermined control signal is sent to the magnetic-force control portion  19   a  via the radio receiving/sending portion of the radio power feed portion  9  of the main body unit  10 A.  
      Alternatively, when the capsule apparatus  1 A reaches a desired portion, a predetermined operation is automatically performed by the signal from the sensing unit, and a predetermined control signal is sent to the magnetic-force control portion  19   a.    
      Thus, the magnetic-force control portion  19   a  generates the magnetic force from a predetermined portion of the magnetic-force generating portion  19   b . The magnetic-force absorbing portion  23 A corresponding to the space in which the desired medical drug  22  is filled is operated, thereby externally spraying the medical drug  22  from the hole portions  21   a  via the spray nozzle  24 A. Then, the medical drug  22  is adhered to a desired portion of the lesion portion in the body cavity of the examinee. The same operation is performed in accordance with the types of the medical drugs  22  filled if necessary.  
      After that, the capsule apparatus  1 A continuously moves by the peristaltic motion in the body cavity, and is naturally discharged out of the body without operations.  
      As mentioned above, according to the second embodiment, the same advantages as those according to the first embodiment are obtained.  
      Further, according to the second embodiment, the internal structure of the medical drug unit  20 A is improved so as to simultaneously fill the medical drug unit  20 A with a plurality of types of medical drugs  22  individually. Further, the medical drugs  22  are individually discharged out at an arbitrary time. Thus, a single capsule apparatus  1 A corresponds to a plurality of medical drugs  22  and to the more complicated curing.  
      Having described the preferred embodiments of the invention referring to the accompanying drawings, it should be understood that the present invention is not limited to those precise embodiments and various changes and modifications thereof could be made by one skilled in the art without departing from the spirit or scope of the invention as defined in the appended claims.