Patent Publication Number: US-2023145692-A1

Title: Plants Having Increased Tolerance to Herbicides

Description:
This application is a continuation of U.S. application Ser. No. 16/317,623, which is a U.S. National Stage application of International Application No. PCT/IB2017/054246, filed Jul. 13, 2017; the entire contents of the aforementioned applications are hereby incorporated by reference herein in their entirety. International Application No. PCT/IB2017/054246 claims the benefit of European Patent Application No. 16179593.5, filed on Jul. 15, 2016. 
    
    
     INCORPORATION BY REFERENCE OF MATERIAL SUBMITTED ELECTRONICALLY 
     The Sequence Listing, which is a part of the present disclosure, is submitted concurrently with the specification in XML format. The name of the text file containing the Sequence Listing is “160566A_SubSeqlisting.XML”, which was created on Dec. 11, 2022 and is 51,987 bytes in size. The subject matter of the Sequence Listing is incorporated herein in its entirety by reference. 
     FIELD OF THE INVENTION 
     The present invention relates in general to methods for conferring on plants agricultural level tolerance to herbicides. Particularly, the invention refers to plants having an increased tolerance to herbicides, more specifically to herbicides which inhibit cellulose biosynthesis, thus, interfere with cell wall biosynthesis. 
     BACKGROUND OF THE INVENTION 
     Microorganisms often respond to the input of xenobiotics into the environment by evolving mechanisms to use them as sources of nutrients and energy for their growth. As the structure of the herbicides based on a s-triazine ring differ from naturally occurring compounds (Esser et al. 1975), microorganisms slowly evolved enzymes and pathways capable of degrading them. The amidohydrolase superfamily comprises a remarkable set of enzymes that catalyze the hydrolysis of a wide range of substrates bearing amide or ester functional groups at carbon and phosphorus centers. In all cases, the nucleophilic water molecule is activated through complexation with a mononuclear or binuclear metal center. In the mononuclear metal centers, the substrate is activated by a proton transfer from the active site, and the water is activated by metal ligation and general base catalysis. The metal centers are perched at the C-terminal end of the beta-barrel core within within a (beta alpha) 8 structural domain. One prominent example is the Atrazine chlorohydrolase (AtzA) an Fe(II)-dependent homohexamer (Seffernick et al. 2002; Wackett et al. 2002a) catalyzing the hydrolytic dechlorination of atrazine, a herbicide, yielding the nonherbicidal product 2-hydroxyatrazine (de Souza et al. 1996; Seffernick et al. 2002; Sadowsky and Wackett 2000). The closest known relative of AtzA is melamine deaminase (TriA from  Pseudomonas  sp. strain NRRL B-12227; 98% sequence identity). Despite their high sequence similarity, AtzA and TriA are catalytically distinct; TriA is a deaminase with a dechlorinase activity several orders below its physiological deaminase activity, while AtzA a dechlorinase with no detectable deaminase activity. Previous work has shown that three of the nine amino acids that differ between the two proteins (S331C; N328D; and F841 AtzA) are largely responsible for the differences in catalytic specificity. 
     The present invention provides new methods to increase herbicide tolerance in plants by the introduction of bacterial genes encoding target proteins that biodegrade the herbicide, in particular cellulose biosynthesis inhibitors named azines. The bacterial enzyme TriA was engineered in a form to remain or increase the amidohydrolase activity and to expand the enzyme pocket towards a more bulky substrate acceptance. The inventors of the present invention have surprisingly found that over-expression of wildtype or mutant melamine deaminase TriA forms confers in plants tolerance/resistance to particular classes of herbicides as compared to the non-transformed and/or non-mutagenized plants or plant cells, respectively. More specifically, the inventors of the present invention have found that TriA expression confers tolerance/resistance to azines. 
     The problem of the present invention can be seen as to the provision of novel traits by identifying target polypeptides, the manipulation of which makes plants tolerant to herbicides. 
     Three main strategies are available for making plants tolerant to herbicides, i.e. (1) detoxifying the herbicide with an enzyme which transforms the herbicide, or its active metabolite, into non-toxic products, such as, for example, the enzymes for tolerance to bromoxynil or to basta (EP242236, EP337899); (2) mutating the target enzyme into a functional enzyme which is less sensitive to the herbicide, or to its active metabolite, such as, for example, the enzymes for tolerance to glyphosate (EP293356, Padgette S. R. et al., J. Biol. Chem., 266, 33, 1991); or (3) overexpressing the sensitive enzyme so as to produce quantities of the target enzyme in the plant which are sufficient in relation to the herbicide, in view of the kinetic constants of this enzyme, so as to have enough of the functional enzyme available despite the presence of its inhibitor. 
     The problem is solved by the subject-matter of the present invention. 
     SUMMARY OF THE INVENTION 
     Accordingly, in one aspect, the present invention provides a plant or plant part comprising a polynucleotide encoding a mutated TriA polypeptide, the expression of said polynucleotide confers to the plant or plant part tolerance to herbicides. 
     In some aspects, the present invention provides a seed capable of germination into a plant comprising in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to herbicides. 
     In one aspect, the present invention provides a plant cell capable of regenerating a plant comprising in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to herbicides, wherein the plant cell comprises the polynucleotide operably linked to a promoter. 
     In another aspect, the present invention provides a plant cell comprising a polynucleotide operably linked to a promoter operable in a cell, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to herbicides. 
     In other aspects, the present invention provides a plant product prepared from a plant or plant part comprising in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to herbicides. 
     In some aspects, the present invention provides a progeny or descendant plant derived from a plant comprising in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, wherein the progeny or descendant plant comprises in at least some of its cells the recombinant polynucleotide operably linked to the promoter, the expression of the mutated TriA polypeptide conferring to the progeny or descendant plant tolerance to the herbicides. 
     In other aspects, the present invention provides a method for controlling weeds at a locus for growth of a plant, the method comprising: (a) applying an herbicide composition comprising herbicides to the locus; and (b) planting a seed at the locus, wherein the seed is capable of producing a plant that comprises in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to herbicides. 
     In some aspects, the present invention provides a method for controlling weeds at a locus for growth of a plant, the method comprising: applying an herbicidal composition comprising herbicides to the locus; wherein said locus is: (a) a locus that contains: a plant or a seed capable of producing said plant; or (b) a locus that is to be after said applying is made to contain the plant or the seed; wherein the plant or the seed comprises in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to herbicides. 
     In one aspect, step (a) occurs before, after, or concurrently with step (b). 
     In other aspects, the present invention provides a method of producing a plant having tolerance to herbicides, the method comprising regenerating a plant from a plant cell transformed with a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to herbicides. 
     In one aspect, the present invention provides a method of producing a progeny plant having tolerance to herbicides, the method comprising: crossing a first herbicide-tolerant plant with a second plant to produce a herbicide-tolerant progeny plant, wherein the first plant and the progeny plant comprise in at least some of their cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to herbicides. 
     In addition, the present invention refers to a method for identifying a herbicide by using a wild-type or mutated TriA of the present invention encoded by a nucleic acid which comprises the nucleotide sequence of SEQ ID NO: 1, or a variant, homologue, paralogue or orthologue thereof. 
     Said method comprises the steps of:
     a) generating a transgenic cell or plant comprising a nucleic acid encoding a mutated TriA of the present invention, wherein the mutated TriA of the present invention is expressed;   b) applying a herbicide to the transgenic cell or plant of a) and to a control cell or plant of the same variety;   c) determining the growth or the viability of the transgenic cell or plant and the control cell or plant after application of said test compound, and   d) selecting test compounds which confer reduced growth to the control cell or plant as compared to the growth of the transgenic cell or plant.   

     Another object refers to a method of identifying a nucleotide sequence encoding a mutated TriA which is resistant or tolerant to a herbicide, the method comprising:
     a) generating a library of mutated TriA-encoding nucleic acids,   b) screening a population of the resulting mutated TriA-encoding nucleic acids by expressing each of said nucleic acids in a cell or plant and treating said cell or plant with a herbicide,   c) comparing the herbicide-tolerance levels provided by said population of mutated TriA encoding nucleic acids with the herbicide-tolerance level provided by a control TriA-encoding nucleic acid,   d) selecting at least one mutated TriA-encoding nucleic acid that provides a significantly increased level of tolerance to a herbicide as compared to that provided by the control TriA-encoding nucleic acid.   

     In a preferred embodiment, the mutated TriA-encoding nucleic acid selected in step d) provides at least 2-fold as much tolerance to a herbicide as compared to that provided by the control TriA-encoding nucleic acid. 
     The resistance or tolerance can be determined by generating a transgenic plant comprising a nucleic acid sequence of the library of step a) and comparing said transgenic plant with a control plant. 
     Another object refers to an isolated, recombinant and/or chemically synthesized nucleic acid encoding a mutated TriA, the nucleic acid comprising the sequence of SEQ ID NO: 1, or a variant thereof, as defined hereinafter. 
     A preferred embodiment refers to an isolated and/or recombinantly produced and/or synthetic nucleic acid molecule comprising a nucleic acid molecule encoding a mutated TriA polypeptide selected from the group consisting of:
         (a) a nucleic acid molecule encoding a mutated TriA polypeptide comprising the sequence of SEQ ID NO: 2, or a variant, paralogue, orthologue or homolog thereof;   (b) a nucleic acid molecule comprising the sequence of SEQ ID NO: 1, or a variant, paralogue, orthologue or homolog thereof;   (c) a nucleic acid molecule, which, as a result of the degeneracy of the genetic code, can be derived from a TriA polypeptide sequence of SEQ ID NO: 2, or a variant, paralogue, orthologue or homolog thereof, and confers increased herbicide tolerance or resistance, as compared to a corresponding, e.g. non-transformed, wild type plant cell, a plant or a part thereof;   (d) a nucleic acid molecule having 30% or more identity, preferably 40%, 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, or more with the nucleic acid molecule sequence of a polynucleotide comprising the nucleic acid molecule of SEQ ID NO: 1, or a variant, paralogue, orthologue or homolog thereof, and confers increased herbicide tolerance or resistance, as compared to a corresponding, e.g. non-transformed, wild type plant cell, a plant or a part thereof;   (e) a nucleic acid molecule encoding a mutated TriA polypeptide having 30% or more identity, preferably at least 40%, 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5% or more, with the amino acid sequence of the TriA polypeptide sequence of SEQ ID NO: 2, and confers increased herbicide tolerance or resistance, as compared to a corresponding, e.g. non-transformed, wild type plant cell, a plant or a part thereof;   (f) nucleic acid molecule which hybridizes with a nucleic acid molecule of (a), (b), (c), (d) or (e) under stringent hybridization conditions and confers increased herbicide tolerance or resistance, as compared to a corresponding, e.g. non-transformed, wild type plant cell, a plant or a part thereof;   wherein the amino acid sequence of the mutated TriA polypeptide differs from the wildtype amino acid sequence of a TriA polypeptide at one or more positions corresponding to the following positions of SEQ ID NO:2: 69, 70, 71, 74, 82, 84, 85, 87, 88, 89, 91, 92, 93, 96, 126, 128, 129, 130, 131, 155, 157, 160, 167, 170, 174, 180, 182, 216, 217, 219, 220, 246, 247, 248, 249, 250, 251, 298, 301, 302, 304, 328.       

     Another object refers to an expression cassette comprising the nucleic acid molecule of the present invention and a promoter operable in plant cells. 
     Preferably, the promoter is a root-specific or root-enhanced promoter from  Glycine max.    
     Another object refers to an isolated, recombinant and/or chemically synthesized mutated TriA polypeptide, the polypeptide comprising the sequence set forth in SEQ ID NO: 2, a variant, derivative, orthologue, paralogue or homologue thereof, as defined hereinafter. 
     Preferably, the amino acid sequence of the mutated TriA polypeptide differs from the wildtype amino acid sequence of a TriA polypeptide at one or more positions corresponding to the following positions of SEQ ID NO:2: 69, 70, 71, 74, 82, 84, 85, 87, 88, 89, 91, 92, 93, 96, 126, 128, 129, 130, 131, 155, 157, 160, 167, 170, 174, 180, 182, 216, 217, 219, 220, 246, 247, 248, 249, 250, 251, 298, 301, 302, 304, 328. 
     In still further aspects, the present invention provides a plant or plant part comprising in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to herbicides, wherein the plant or plant part further exhibits a second or third herbicide-tolerant trait. 
     In another embodiment, the invention refers to a plant cell transformed by and expressing a wildtype or a mutated TriA nucleic acid according to the present invention or a plant which has been mutated to obtain a plant expressing, preferably overexpressing a wildtype or a mutated TriA nucleic acid according to the present invention, wherein expression of said nucleic acid in the plant cell results in increased resistance or tolerance to a herbicide as compared to a wildtype variety of the plant cell 
     In another embodiment, the invention refers to a plant comprising a plant cell according to the present invention, wherein expression of the nucleic acid in the plant results in the plant&#39;s increased resistance to herbicide as compared to a wildtype variety of the plant. 
     Preferably, the expression of the nucleic acid of the invention in the plant results in the plant&#39;s increased resistance to herbicides as compared to a wildtype variety of the plant. 
     In another embodiment, the invention refers to a seed produced by a transgenic plant comprising a plant cell of the present invention, wherein the seed is true breeding for an increased resistance to a herbicide as compared to a wildtype variety of the seed. 
     In another embodiment, the invention refers to a method of producing a transgenic plant cell with an increased resistance to a herbicide as compared to a wildtype variety of the plant cell comprising, transforming the plant cell with an expression cassette comprising a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide. 
     In another embodiment, the invention refers to a method of producing a transgenic plant comprising, (a) transforming a plant cell with an expression cassette comprising a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, and (b) generating a plant with an increased resistance to herbicide from the plant cell. 
     Preferably, the expression cassette further comprises a transcription initiation regulatory region and a translation initiation regulatory region that are functional in the plant. 
    
    
     
       DESCRIPTION OF THE DRAWINGS 
         FIG.  1    shows the preemergence tolerance assessment of soybean plants treated with azines. Phenotypic development of wildtype (A) and transgenic event expressing triA mutant variant of SEQ ID NO: 2 containing amino acid substitutions at four positions, namely L92A_Y93L_M155T_F157L (B). Indicated values reflect [g/ha] amount of 6-cyclopentyl-N4-(2,3,4,5,6-pentafluorophenyl)-1,3,5-triazine-2,4-diamine. The upper part of each plant shows stung shoots, lower part shows root injury. 
         FIG.  2    shows the preemergence tolerance assessment of corn plants treated with azines. Phenotypic development of wildtype (A) and transgenic event expressing triA mutant variant of SEQ ID NO: 2 containing amino acid substitutions at four positions, namely L92A_Y93L_M155T_F157L (B). Indicated values reflect [g/ha] amount of 6-cyclopentyl-N4-(2,3,4,5,6-pentafluorophenyl)-1,3,5-triazine-2,4-diamine. 
     
    
    
     DETAILED DESCRIPTION 
     The articles “a” and “an” are used herein to refer to one or more than one (i.e., to at least one) of the grammatical object of the article. By way of example, “an element” means one or more elements. 
     As used herein, the word “comprising,” or variations such as “comprises” or “comprising,” will be understood to imply the inclusion of a stated element, integer or step, or group of elements, integers or steps, but not the exclusion of any other element, integer or step, or group of elements, integers or steps. 
     The term “control of undesired vegetation or weeds” is to be understood as meaning the killing of weeds and/or otherwise retarding or inhibiting the normal growth of the weeds. Weeds, in the broadest sense, are understood as meaning all those plants which grow in locations where they are undesired. The weeds of the present invention include, for example, dicotyledonous and monocotyledonous weeds. Dicotyledonous weeds include, but are not limited to, weeds of the genera:  Sinapis, Lepidium, Galium, Stellaria, Matricaria, Anthemis, Galinsoga, Chenopodium, Urtica, Senecio, Amaranthus, Portulaca, Xanthium, Convolvulus, Ipomoea, Polygonum, Sesbania, Ambrosia, Cirsium, Carduus, Sonchus, Solanum, Rorippa, Rotala, Lindernia, Lamium, Veronica, Abutilon, Emex, Datura, Viola, Galeopsis, Papaver, Centaurea, Trifolium, Ranunculus , and  Taraxacum. Monocotyledonous weeds include, but are not limited to, weeds of of the genera: Echinochloa, Setaria, Panicum, Digitaria, Phleum, Poa, Festuca, Eleusine, Brachiaria, Lolium, Bromus, Avena, Cyperus, Sorghum, Agropyron, Cynodon, Monochoria, Fimbristyslis, Sagittaria, Eleocharis, Scirpus, Paspalum, Ischaemum, Sphenoclea, Dactyloctenium, Agrostis, Alopecurus , and  Apera . In addition, the weeds of the present invention can include, for example, crop plants that are growing in an undesired location. For example, a volunteer maize plant that is in a field that predominantly comprises soybean plants can be considered a weed, if the maize plant is undesired in the field of soybean plants. 
     The term “plant” is used in its broadest sense as it pertains to organic material and is intended to encompass eukaryotic organisms that are members of the Kingdom Plantae, examples of which include but are not limited to vascular plants, vegetables, grains, flowers, trees, herbs, bushes, grasses, vines, ferns, mosses, fungi and algae, etc, as well as clones, offsets, and parts of plants used for asexual propagation (e.g. cuttings, pipings, shoots, rhizomes, underground stems, clumps, crowns, bulbs, corms, tubers, rhizomes, plants/tissues produced in tissue culture, etc.). The term “plant” further encompasses whole plants, ancestors and progeny of the plants and plant parts, including seeds, shoots, stems, leaves, roots (including tubers), flowers, florets, fruits, pedicles, peduncles, stamen, anther, stigma, style, ovary, petal, sepal, carpel, root tip, root cap, root hair, leaf hair, seed hair, pollen grain, microspore, cotyledon, hypocotyl, epicotyl, xylem, phloem, parenchyma, endosperm, a companion cell, a guard cell, and any other known organs, tissues, and cells of a plant, and tissues and organs, wherein each of the aforementioned comprise the gene/nucleic acid of interest. The term “plant” also encompasses plant cells, suspension cultures, callus tissue, embryos, meristematic regions, gametophytes, sporophytes, pollen and microspores, again wherein each of the aforementioned comprises the gene/nucleic acid of interest. 
     Plants that are particularly useful in the methods of the invention include all plants which belong to the superfamily Viridiplantae, in particular monocotyledonous and dicotyledonous plants including fodder or forage legumes, ornamental plants, food crops, trees or shrubs selected from the list comprising  Acer  spp.,  Actinidia  spp.,  Abelmoschus  spp.,  Agave sisalana, Agropyron  spp.,  Agrostis stolonifera, Allium  spp., Amaranth us spp.,  Ammophila arenaria, Ananas comosus , Annona spp.,  Apium graveolens, Arachis  spp,  Artocarpus  spp.,  Asparagus officinalis, Avena  spp. (e.g.  Avena sativa, Avena fatua, Avena byzantina, Avena fatua  var.  sativa, Avena hybrida ),  Averrhoa carambola, Bambusa  sp.,  Benincasa hispida, Bertholletia excelsea, Beta vulgaris, Brassica  spp. (e.g.  Brassica napus, Brassica rapa  ssp. [canola, oilseed rape, turnip rape]),  Cadaba farinosa, Camellia sinensis, Canna indica, Cannabis sativa, Capsicum  spp.,  Carex elata, Carica papaya, Carissa macrocarpa, Carya  spp.,  Carthamus tinctorius, Castanea  spp.,  Ceiba pentandra, Cichorium endivia, Cinnamomum  spp.,  Citrullus lanatus, Citrus  spp.,  Cocos  spp.,  Coffea  spp.,  Colocasia esculenta, Cola  spp.,  Corchorus  sp.,  Coriandrum sativum, Corylus  spp.,  Crataegus  spp.,  Crocus sativus, Cucurbita  spp.,  Cucumis  spp.,  Cynara  spp.,  Daucus carota, Desmodium  spp.,  Dimocarpus longan, Dioscorea  spp.,  Diospyros  spp.,  Echinochloa  spp.,  Elaeis  (e.g.  Elaeis guineensis, Elaeis  oleifera),  Eleusine coracana, Eragrostis tef, Erianthus  sp.,  Eriobotrya japonica, Eucalyptus  sp.,  Eugenia uniflora, Fagopyrum  spp.,  Fagus  spp.,  Festuca arundinacea, Ficus carica, Fortunella  spp.,  Fragaria  spp.,  Ginkgo biloba, Glycine  spp. (e.g.  Glycine max, Soja hispida  or  Soja max ),  Gossypium hirsutum, Helianthus  spp. (e.g.  Helianthus annuus ),  Hemerocallis fulva, Hibiscus  spp.,  Hordeum  spp. (e.g.  Hordeum vulgare ),  Ipomoea batatas, Juglans  spp.,  Lactuca sativa, Lathyrus  spp.,  Lens culinaris, Linum usitatissimum, Litchi chinensis, Lotus  spp.,  Luffa acutangula, Lupinus  spp.,  Luzula sylvatica, Lycopersicon  spp. (e.g.  Lycopersicon esculentum, Lycopersicon lycopersicum, Lycopersicon pyriforme ),  Macrotyloma  spp.,  Malus  spp.,  Malpighia emarginata, Mammea americana, Mangifera indica, Manihot  spp.,  Manilkara zapota, Medicago sativa, Melilotus  spp.,  Mentha  spp.,  Miscanthus sinensis, Momordica  spp.,  Morus nigra, Musa  spp.,  Nicotiana  spp.,  Olea  spp.,  Opuntia  spp.,  Ornithopus  spp.,  Oryza  spp. (e.g.  Oryza sativa, Oryza latifolia ),  Panicum miliaceum, Panicum virgatum, Passiflora edulis, Pastinaca sativa, Pennisetum  sp.,  Persea  spp.,  Petroselinum crispum, Phalaris arundinacea, Phaseolus  spp.,  Phleum pratense, Phoenix  spp.,  Phragmites australis, Physalis  spp.,  Pinus  spp.,  Pistacia vera, Pisum  spp.,  Poa  spp.,  Populus  spp.,  Prosopis  spp.,  Prunus  spp.,  Psidium  spp.,  Punica granatum, Pyrus communis, Quercus  spp.,  Raphanus sativus, Rheum rhabarbarum, Ribes  spp.,  Ricinus communis, Rubus  spp.,  Saccharum  spp.,  Salix  sp.,  Sambucus  spp.,  Secale cereale, Sesamum  spp.,  Sinapis  sp.,  Solanum  spp. (e.g.  Solanum tuberosum, Solanum integrifolium  or  Solanum lycopersicum ),  Sorghum bicolor, Spinacia  spp.,  Syzygium  spp.,  Tagetes  spp.,  Tamarind us indica, Theobroma cacao, Trifolium  spp.,  Tripsacum dactyloides, Triticosecale rimpaui, Triticum  spp. (e.g.  Triticum aestivum, Triticum durum, Triticum turgidum, Triticum hybernum, Triticum macha, Triticum sativum, Triticum monococcum  or  Triticum vulgare ),  Tropaeolum minus, Tropaeolum majus, Vaccinium  spp.,  Vicia  spp.,  Vigna  spp.,  Viola odorata, Vitis  spp.,  Zea mays, Zizania palustris , Ziziphus spp., amaranth, artichoke, asparagus, broccoli, Brussels sprouts, cabbage, canola, carrot, cauliflower, celery, collard greens, flax, kale, lentil, oilseed rape, okra, onion, potato, rice, soybean, strawberry, sugar beet, sugar cane, sunflower, tomato, squash, tea and algae, amongst others. According to a preferred embodiment of the present invention, the plant is a crop plant. Examples of crop plants include inter alia soybean, sunflower, canola, alfalfa, rapeseed, cotton, tomato, potato or tobacco. Further preferebly, the plant is a monocotyledonous plant, such as sugarcane. Further preferably, the plant is a cereal, such as rice, maize, wheat, barley, millet, rye, sorghum or oats. 
     Generally, the term “herbicide” is used herein to mean an active ingredient that kills, controls or otherwise adversely modifies the growth of plants. The preferred amount or concentration of the herbicide is an “effective amount” or “effective concentration.” By “effective amount” and “effective concentration” is intended an amount and concentration, respectively, that is sufficient to kill or inhibit the growth of a similar, wild-type, plant, plant tissue, plant cell, or host cell, but that said amount does not kill or inhibit as severely the growth of the herbicide-resistant plants, plant tissues, plant cells, and host cells of the present invention. Typically, the effective amount of a herbicide is an amount that is routinely used in agricultural production systems to kill weeds of interest. Such an amount is known to those of ordinary skill in the art. Herbicidal activity is exhibited by herbicides useful for the the present invention when they are applied directly to the plant or to the locus of the plant at any stage of growth or before planting or emergence. The effect observed depends upon the plant species to be controlled, the stage of growth of the plant, the application parameters of dilution and spray drop size, the particle size of solid components, the environmental conditions at the time of use, the specific compound employed, the specific adjuvants and carriers employed, the soil type, and the like, as well as the amount of chemical applied. These and other factors can be adjusted as is known in the art to promote non-selective or selective herbicidal action. Generally, the herbicide treatments can be applied PPI (Pre Plant Incorporated), PPSA (Post plant surface applied), PRE- or POST-emergent. Postemergent treatment typically occurs to relatively immature undesirable vegetation to achieve the maximum control of weeds. 
     By a “herbicide-tolerant” or “herbicide-resistant” plant, it is intended that a plant that is tolerant or resistant to at least one herbicide at a level that would normally kill, or inhibit the growth of, a normal or wildtype plant. Levels of herbicide that normally inhibit growth of a non-tolerant plant are known and readily determined by those skilled in the art. Examples include the amounts recommended by manufacturers for application. The maximum rate is an example of an amount of herbicide that would normally inhibit growth of a non-tolerant plant. For the present invention, the terms “herbicide-tolerant” and “herbicide-resistant” are used interchangeably and are intended to have an equivalent meaning and an equivalent scope. Similarly, the terms “herbicide-tolerance” and “herbicide-resistance” are used interchangeably and are intended to have an equivalent meaning and an equivalent scope. Similarly, the terms “tolerant” and “resistant” are used interchangeably and are intended to have an equivalent meaning and an equivalent scope. As used herein, in regard to an herbicidal composition useful in various embodiments hereof, terms such as herbicides, and the like, refer to those agronomically acceptable herbicide active ingredients (A.I.) recognized in the art. Similarly, terms such as fungicide, nematicide, pesticide, and the like, refer to other agronomically acceptable active ingredients recognized in the art. 
     When used in reference to a particular mutant enzyme or polypeptide, terms such as herbicide-tolerant and herbicide-tolerance refer to the ability of such enzyme or polypeptide to perform its physiological activity in the presence of an amount of an herbicide A.I. that would normally inactivate or inhibit the activity of the wild-type (non-mutant) version of said enzyme or polypeptide. On the other hand, when used specifically in regard to a TriA enzyme, it refers specifically to the ability to metabolize, and thereby inactivate herbicides which inhibit cellulose biosynthesis, so-called cellulose biosynthesis inhibitors (CBI) By “herbicide-tolerant mutated TriA protein” or “herbicide-resistant mutated TriA protein”, it is intended that such a TriA protein displays higher metabolizing activity, relative to the metabolizing activity of a wild-type TriA protein, when in the presence of at least one herbicide that is known to interfere with cellulose biosynthesis and at a concentration or level of the herbicide that is known to inhibit cellulose biosynthesis. Furthermore, the TriA activity of such a herbicide-tolerant or herbicide-resistant mutated TriA protein may be referred to herein as “herbicide-tolerant” or “herbicide-resistant” TriA activity. 
     As used herein, “recombinant,” when referring to nucleic acid or polypeptide, indicates that such material has been altered as a result of human application of a recombinant technique, such as by polynucleotide restriction and ligation, by polynucleotide overlap-extension, or by genomic insertion or transformation. A gene sequence open reading frame is recombinant if that nucleotide sequence has been removed from it natural text and cloned into any type of artificial nucleic acid vector. The term recombinant also can refer to an organism having a recombinant material, e.g., a plant that comprises a recombinant nucleic acid can be considered a recombinant plant. 
     The term “transgenic plant” refers to a plant that comprises a heterologous polynucleotide. Preferably, the heterologous polynucleotide is stably integrated within the genome such that the polynucleotide is passed on to successive generations. The heterologous polynucleotide may be integrated into the genome alone or as part of a recombinant expression cassette. “Transgenic” is used herein to refer to any cell, cell line, callus, tissue, plant part or plant, the genotype of which has been so altered by the presence of heterologous nucleic acid including those transgenic organisms or cells initially so altered, as well as those created by crosses or asexual propagation from the initial transgenic organism or cell. In some embodiments, a “recombinant” organism is a “transgenic” organism. The term “transgenic” as used herein is not intended to encompass the alteration of the genome (chromosomal or extra-chromosomal) by conventional plant breeding methods (e.g., crosses) or by naturally occurring events such as, e.g., self-fertilization, random cross-fertilization, non-recombinant viral infection, non-recombinant bacterial transformation, non-recombinant transposition, or spontaneous mutation. 
     As used herein, “mutagenized” refers to an organism or DNA thereof having alteration(s) in the biomolecular sequence of its native genetic material as compared to the sequence of the genetic material of a corresponding wildtype organism or DNA, wherein the alteration(s) in genetic material were induced and/or selected by human action. Examples of human action that can be used to produce a mutagenized organism or DNA include, but are not limited to treatment with a chemical mutagen such as EMS and subsequent selection with herbicide(s); or by treatment of plant cells with x-rays and subsequent selection with herbicide(s). Any method known in the art can be used to induce mutations. Methods of inducing mutations can induce mutations in random positions in the genetic material or can induce mutations in specific locations in the genetic material (i.e., can be directed mutagenesis techniques), such as by use of a genoplasty technique. 
     As used herein, a “genetically modified organism” (GMO) is an organism whose genetic characteristics contain alteration(s) that were produced by human effort causing transfection that results in transformation of a target organism with genetic material from another or “source” organism, or with synthetic or modified-native genetic material, or an organism that is a descendant thereof that retains the inserted genetic material. The source organism can be of a different type of organism (e.g., a GMO plant can contain bacterial genetic material) or from the same type of organism (e.g., a GMO plant can contain genetic material from another plant). As used herein in regard to plants and other organisms, “recombinant,” “transgenic,” and “GMO” are considered synonyms and indicate the presence of genetic material from a different source; in contrast, “mutagenized” is used to refer to a plant or other organism, or the DNA thereof, in which no such transgenic material is present, but in which the native genetic material has become mutated so as to differ from a corresponding wild-type organism or DNA. 
     As used herein, “wildtype” or “corresponding wildtype plant” means the typical form of an organism or its genetic material, as it normally occurs, as distinguished from, e.g., mutagenized and/or recombinant forms. Similarly, by “control cell” or “similar, wildtype, plant, plant tissue, plant cell or host cell” is intended a plant, plant tissue, plant cell, or host cell, respectively, that lacks the herbicide-resistance characteristics and/or particular polynucleotide of the invention that are disclosed herein. The use of the term “wildtype” is not, therefore, intended to imply that a plant, plant tissue, plant cell, or other host cell lacks recombinant DNA in its genome, and/or does not possess herbicide-resistant characteristics that are different from those disclosed herein. 
     As used herein, “descendant” refers to any generation plant. In some embodiments, a descendant is a first, second, third, fourth, fifth, sixth, seventh, eight, ninth, or tenth generation plant. 
     As used herein, “progeny” refers to a first generation plant. 
     The term “seed” comprises seeds of all types, such as, for example, true seeds, caryopses, achenes, fruits, tubers, seedlings and similar forms. In the context of  Brassica  and  Sinapis  species, “seed” refers to true seed(s) unless otherwise specified. For example, the seed can be seed of transgenic plants or plants obtained by traditional breeding methods. Examples of traditional breeding methods can include cross-breeding, selfing, back-crossing, embryo rescue, in-crossing, out-crossing, inbreeding, selection, asexual propagation, and other traditional techniques as are known in the art. 
     Although exemplified with reference to specific plants or plant varieties and their hybrids, in various embodiments, the presently described methods using herbicides can be employed with a variety of commercially valuable plants. Herbicide-tolerant plant lines described as useful herein can be employed in weed control methods either directly or indirectly, i. e. either as crops for herbicide treatment or as herbicide-tolerance trait donor lines for development, to produce other varietal and/or hybrid crops containing such trait or traits. All such resulting variety or hybrids crops, containing the ancestral herbicide-tolerance trait or traits can be referred to herein as progeny or descendant of the ancestral, herbicide-tolerant line(s). Such resulting plants can be said to retain the “herbicide tolerance characteristic(s)” of the ancestral plant, i.e. meaning that they possess and express the ancestral genetic molecular components responsible for the trait. 
     In one aspect, the present invention provides a plant or plant part comprising a polynucleotide encoding a mutated TriA polypeptide, the expression of said polynucleotide confers to the plant or plant part tolerance to herbicides. 
     In a preferred embodiment, the plant has been previously produced by a process comprising recombinantly preparing a plant by introducing and over-expressing a wild-type or mutated TriA transgene according to the present invention, as described in greater detail hereinfter. 
     In another embodiment, the polynucleotide encoding the mutated TriA polypeptide polypeptide comprises the nucleic acid sequence set forth in SEQ ID NO: 1, or a variant or derivative thereof. 
     In other embodiments, the mutated TriA polypeptide according to the present invention is a functional variant having, over the full-length of the variant, at least about 80%, illustratively, at least about 80%, 90%, 95%, 98%, 99% or more amino acid sequence identity to SEQ ID NO: 2. 
     In another embodiment, the mutated TriA polypeptide for use according to the present invention is a functional fragment of a polypeptide having the amino acid sequence set forth in SEQ ID NO: 2. 
     It is recognized that the TriA polynucleotide molecules and TriA polypeptides of the invention encompass polynucleotide molecules and polypeptides comprising a nucleotide or an amino acid sequence that is sufficiently identical to nucleotide sequence set forth in SEQ ID Nos: 1, or to the amino acid sequence set forth in SEQ ID Nos: 2. The term “sufficiently identical” is used herein to refer to a first amino acid or nucleotide sequence that contains a sufficient or minimum number of identical or equivalent (e.g., with a similar side chain) amino acid residues or nucleotides to a second amino acid or nucleotide sequence such that the first and second amino acid or nucleotide sequences have a common structural domain and/or common functional activity. 
     Generally, “sequence identity” refers to the extent to which two optimally aligned DNA or amino acid sequences are invariant throughout a window of alignment of components, e.g., nucleotides or amino acids. An “identity fraction” for aligned segments of a test sequence and a reference sequence is the number of identical components that are shared by the two aligned sequences divided by the total number of components in reference sequence segment, i.e., the entire reference sequence or a smaller defined part of the reference sequence. “Percent identity” is the identity fraction times 100. Optimal alignment of sequences for aligning a comparison window are well known to those skilled in the art and may be conducted by tools such as the local homology algorithm of Smith and Waterman, the homology alignment algorithm of Needleman and Wunsch, the search for similarity method of Pearson and Lipman, and preferably by computerized implementations of these algorithms such as GAP, BESTFIT, FASTA, and TFASTA available as part of the GCG. Wisconsin Package. (Accelrys Inc. Burlington, Mass.) 
     Polynucleotides and Oligonucleotides 
     By an “isolated polynucleotide”, including DNA, RNA, or a combination of these, single or double stranded, in the sense or antisense orientation or a combination of both, dsRNA or otherwise, we mean a polynucleotide which is at least partially separated from the polynucleotide sequences with which it is associated or linked in its native state. Preferably, the isolated polynucleotide is at least 60% free, preferably at least 75% free, and most preferably at least 90% free from other components with which they are naturally associated. As the skilled addressee would be aware, an isolated polynucleotide can be an exogenous polynucleotide present in, for example, a transgenic organism which does not naturally comprise the polynucleotide. Furthermore, the terms “polynucleotide(s)”, “nucleic acid sequence(s)”, “nucleotide sequence(s)”, “nucleic acid(s)”, “nucleic acid molecule” are used interchangeably herein and refer to nucleotides, either ribonucleotides or deoxyribonucleotides or a combination of both, in a polymeric unbranched form of any length. 
     The term “mutated TriA nucleic acid” refers to a TriA nucleic acid having a sequence that is mutated from a wild-type TriA nucleic acid and that confers increased herbicide tolerance to a plant in which it is expressed. Furthermore, the term “mutated melamine deaminase (mutated TriA)” refers to the replacement of an amino acid of the wild-type primary sequence of SEQ ID NO: 2, or a variant, a derivative, a homologue, an orthologue, or paralogue thereof, with another amino acid. The expression “mutated amino acid” will be used below to designate the amino acid which is replaced by another amino acid, thereby designating the site of the mutation in the primary sequence of the protein. 
     In a preferred embodiment, the TriA nucleotide sequence encoding a mutated TriA comprises the sequence of SEQ ID NO: 1, or a variant or derivative thereof 
     Furthermore, it will be understood by the person skilled in the art that the TriA nucleotide sequences encompasse homologues, paralogues and and orthologues of SEQ ID NO: 1, as defined hereinafter. 
     The term “variant” with respect to a sequence (e.g., a polypeptide or nucleic acid sequence such as—for example—a transcription regulating nucleotide sequence of the invention) is intended to mean substantially similar sequences. For nucleotide sequences comprising an open reading frame, variants include those sequences that, because of the degeneracy of the genetic code, encode the identical amino acid sequence of the native protein. Naturally occurring allelic variants such as these can be identified with the use of well-known molecular biology techniques, as, for example, with polymerase chain reaction (PCR) and hybridization techniques. Variant nucleotide sequences also include synthetically derived nucleotide sequences, such as those generated, for example, by using site-directed mutagenesis and for open reading frames, encode the native protein comprising the sequence of SEQ ID NO: 2, as well as those that encode a polypeptide having amino acid substitutions relative to the native protein, e.g. the mutated TriA according to the present invention as disclosed herein. Generally, nucleotide sequence variants of the invention will have at least 30, 40, 50, 60, to 70%, e.g., preferably 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, to 79%, generally at least 80%, e.g., 81%-84%, at least 85%, e.g., 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, to 98% and 99% nucleotide “sequence identity” to the nucleotide sequence of SEQ ID NO: 1. The % identity of a polynucleotide is determined by GAP (Needleman and Wunsch, 1970) analysis (GCG program) with a gap creation penalty=5, and a gap extension penalty=0.3. Unless stated otherwise, the query sequence is at least 45 nucleotides in length, and the GAP analysis aligns the two sequences over a region of at least 45 nucleotides. Preferably, the query sequence is at least 150 nucleotides in length, and the GAP analysis aligns the two sequences over a region of at least 150 nucleotides. More preferably, the query sequence is at least 300 nucleotides in length and the GAP analysis aligns the two sequences over a region of at least 300 nucleotides. Even more preferably, the GAP analysis aligns the two sequences over their entire length. 
     Polypeptides 
     By “substantially purified polypeptide” or “purified” a polypeptide is meant that has been separated from one or more lipids, nucleic acids, other polypeptides, or other contaminating molecules with which it is associated in its native state. It is preferred that the substantially purified polypeptide is at least 60% free, more preferably at least 75% free, and more preferably at least 90% free from other components with which it is naturally associated. As the skilled addressee will appreciate, the purified polypeptide can be a recombinantly produced polypeptide. The terms “polypeptide” and “protein” are generally used interchangeably and refer to a single polypeptide chain which may or may not be modified by addition of non-amino acid groups. It would be understood that such polypeptide chains may associate with other polypeptides or proteins or other molecules such as co-factors. The terms “proteins” and “polypeptides” as used herein also include variants, mutants, modifications, analogous and/or derivatives of the polypeptides of the invention as described herein. 
     The % identity of a polypeptide is determined by GAP (Needleman and Wunsch, 1970) analysis (GCG program) with a gap creation penalty=5, and a gap extension penalty=0.3. The query sequence is at least 25 amino acids in length, and the GAP analysis aligns the two sequences over a region of at least 25 amino acids. More preferably, the query sequence is at least 50 amino acids in length, and the GAP analysis aligns the two sequences over a region of at least 50 amino acids. More preferably, the query sequence is at least 100 amino acids in length and the GAP analysis aligns the two sequences over a region of at least 100 amino acids. Even more preferably, the query sequence is at least 250 amino acids in length and the GAP analysis aligns the two sequences over a region of at least 250 amino acids. Even more preferably, the GAP analysis aligns the two sequences over their entire length. 
     With regard to a defined polypeptide, it will be appreciated that % identity figures higher than those provided above will encompass preferred embodiments. Thus, where applicable, in light of the minimum % identity figures, it is preferred that the TriA polypeptide of the invention comprises an amino acid sequence which is at least 40%, more preferably at least 45%, more preferably at least 50%, more preferably at least 55%, more preferably at least 60%, more preferably at least 65%, more preferably at least 70%, more preferably at least 75%, more preferably at least 80%, more preferably at least 85%, more preferably at least 90%, more preferably at least 91%, more preferably at least 92%, more preferably at least 93%, more preferably at least 94%, more preferably at least 95%, more preferably at least 96%, more preferably at least 97%, more preferably at least 98%, more preferably at least 99%, more preferably at least 99.1%, more preferably at least 99.2%, more preferably at least 99.3%, more preferably at least 99.4%, more preferably at least 99.5%, more preferably at least 99.6%, more preferably at least 99.7%, more preferably at least 99.8%, and even more preferably at least 99.9% identical to SEQ ID NO: 2. 
     By “variant” polypeptide is intended a polypeptide derived from the protein of SEQ ID NO: 2, by deletion (so-called truncation) or addition of one or more amino acids to the N-terminal and/or C-terminal end of the native protein; deletion or addition of one or more amino acids at one or more sites in the native protein; or substitution of one or more amino acids at one or more sites in the native protein. Such variants may result from, for example, genetic polymorphism or from human manipulation. Methods for such manipulations are generally known in the art. 
     “Derivatives” of a protein encompass peptides, oligopeptides, polypeptides, proteins and enzymes having amino acid substitutions, deletions and/or insertions relative to the unmodified protein in question and having similar biological and functional activity as the unmodified protein from which they are derived. Thus, functional variants and fragments of the TriA polypeptides, and nucleic acid molecules encoding them, also are within the scope of the present invention, and unless specifically described otherwise, irrespective of the origin of said polypeptide and irrespective of whether it occurs naturally. Various assays for functionality of a TriA polypeptide can be employed. For example, a functional variant or fragment of the TriA polypeptide can be assayed to determine its ability to confer herbicides detoxification. By way of illustration, a herbicides detoxification rate can be defined as a catalytic rate sufficient to provide a determinable increase in tolerance to herbicides in a plant or plant part comprising a recombinant polynucleotide encoding the variant or fragment of the TriA polypeptide, wherein the plant or plant part expresses the variant or fragment at up to about 0.5%, illustratively, about 0.05 to about 0.5%, about 0.1 to about 0.4%, and about 0.2 to about 0.3%, of the total cellular protein relative to a similarly treated control plant that does not express the variant or fragment. 
     In a preferred embodiment, the mutated TriA polypeptide is a functional variant or fragment of a melamine deaminase having the amino acid sequence set forth in SEQ ID NO: 2, wherein the functional variant or fragment has at least about 80% amino acid sequence identity to SEQ ID NO: 2. 
     In other embodiments, the functional variant or fragment further has a herbicides detoxification rate defined as a catalytic rate sufficient to provide a determinable increase in tolerance to herbicides in a plant or plant part comprising a recombinant polynucleotide encoding the variant or fragment, wherein the plant or plant part expresses the variant or fragment at up to about 0.5% of the total cellular protein to a similarly treated control plant that does not express the variant or fragment. 
     “Homologues” of a protein encompass peptides, oligopeptides, polypeptides, proteins and enzymes having amino acid substitutions, deletions and/or insertions relative to the unmodified protein in question and having similar biological and functional activity as the unmodified protein from which they are derived. 
     In addition, one of ordinary skill in the art will further appreciate that changes can be introduced by mutation into the nucleotide sequences of the invention thereby leading to changes in the amino acid sequence of the encoded proteins without altering the biological activity of the proteins. Thus, for example, an isolated polynucleotide molecule encoding a mutated TriA polypeptide having an amino acid sequence that differs from that of SEQ ID NO: 2 can be created by introducing one or more nucleotide substitutions, additions, or deletions into the corresponding nucleotide sequence, such that one or more amino acid substitutions, additions or deletions are introduced into the encoded protein. Mutations can be introduced by standard techniques, such as site-directed mutagenesis and PCR-mediated mutagenesis. Such variant nucleotide sequences are also encompassed by the present invention. For example, preferably, conservative amino acid substitutions may be made at one or more predicted preferably nonessential amino acid residues. A “nonessential” amino acid residue is a residue that can be altered from the wild-type sequence of a protein without altering the biological activity, whereas an “essential” amino acid residue is required for biological activity. A deletion refers to removal of one or more amino acids from a protein. 
     An insertion refers to one or more amino acid residues being introduced into a predetermined site in a protein. Insertions may comprise N-terminal and/or C-terminal fusions as well as intra-sequence insertions of single or multiple amino acids. Generally, insertions within the amino acid sequence will be smaller than N- or C-terminal fusions, of the order of about 1 to 10 residues. Examples of N- or C-terminal fusion proteins or peptides include the binding domain or activation domain of a transcriptional activator as used in the yeast two-hybrid system, phage coat proteins, (histidine)-6-tag, glutathione S-transferase-tag, protein A, maltose-binding protein, dihydrofolate reductase, Tag⋅100 epitope, c-myc epitope, FLAG®-epitope, lacZ, CMP (calmodulin-binding peptide), HA epitope, protein C epitope and VSV epitope. 
     A substitution refers to replacement of amino acids of the protein with other amino acids having similar properties (such as similar hydrophobicity, hydrophilicity, antigenicity, propensity to form or break α-helical structures or β-sheet structures). Amino acid substitutions are typically of single residues, but may be clustered depending upon functional constraints placed upon the polypeptide and may range from 1 to 10 amino acids; insertions will usually be of the order of about 1 to 10 amino acid residues. A conservative amino acid substitution is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Such substitutions would not be made for conserved amino acid residues, or for amino acid residues residing within a conserved motif. Conservative substitution tables are well known in the art (see for example Creighton (1984) Proteins. W.H. Freeman and Company (Eds). 
     Amino acid substitutions, deletions and/or insertions may readily be made using peptide synthetic techniques well known in the art, such as solid phase peptide synthesis and the like, or by recombinant DNA manipulation. Methods for the manipulation of DNA sequences to produce substitution, insertion or deletion variants of a protein are well known in the art. For example, techniques for making substitution mutations at predetermined sites in DNA are well known to those skilled in the art and include M13 mutagenesis, T7-Gen in vitro mutagenesis (USB, Cleveland, Ohio), QuickChange Site Directed mutagenesis (Stratagene, San Diego, Calif.), PCR-mediated site-directed mutagenesis or other site-directed mutagenesis protocols. 
     “Derivatives” further include peptides, oligopeptides, polypeptides which may, compared to the amino acid sequence of the naturally-occurring form of the protein, such as the protein of interest, comprise substitutions of amino acids with non-naturally occurring amino acid residues, or additions of non-naturally occurring amino acid residues. “Derivatives” of a protein also encompass peptides, oligopeptides, polypeptides which comprise naturally occurring altered (glycosylated, acylated, prenylated, phosphorylated, myristoylated, sulphated etc.) or non-naturally altered amino acid residues compared to the amino acid sequence of a naturally-occurring form of the polypeptide. A derivative may also comprise one or more non-amino acid substituents or additions compared to the amino acid sequence from which it is derived, for example a reporter molecule or other ligand, covalently or non-covalently bound to the amino acid sequence, such as a reporter molecule which is bound to facilitate its detection, and non-naturally occurring amino acid residues relative to the amino acid sequence of a naturally-occurring protein. Furthermore, “derivatives” also include fusions of the naturally-occurring form of the protein with tagging peptides such as FLAG, HIS6 or thioredoxin (for a review of tagging peptides, see Terpe, Appl. Microbiol. Biotechnol. 60, 523-533, 2003). 
     “Orthologues” and “paralogues” encompass evolutionary concepts used to describe the ancestral relationships of genes. Paralogues are genes within the same species that have originated through duplication of an ancestral gene; orthologues are genes from different organisms that have originated through speciation, and are also derived from a common ancestral gene. 
     Variants, orthologues and paralogues of SEQ ID NO:2 encompassed by the present invention are shown, but not limited to polypeptides comprising SEQ ID NO: 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, or 31. 
     It is well-known in the art that paralogues and orthologues may share distinct domains harboring suitable amino acid residues at given sites, such as binding pockets for particular substrates or binding motifs for interaction with other proteins. 
     The term “domain” refers to a set of amino acids conserved at specific positions along an alignment of sequences of evolutionarily related proteins. While amino acids at other positions can vary between homologues, amino acids that are highly conserved at specific positions indicate amino acids that are likely essential in the structure, stability or function of a protein. Identified by their high degree of conservation in aligned sequences of a family of protein homologues, they can be used as identifiers to determine if any polypeptide in question belongs to a previously identified polypeptide family. 
     The term “motif” or “consensus sequence” refers to a short conserved region in the sequence of evolutionarily related proteins. Motifs are frequently highly conserved parts of domains, but may also include only part of the domain, or be located outside of conserved domain (if all of the amino acids of the motif fall outside of a defined domain). 
     Specialist databases exist for the identification of domains, for example, SMART (Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864; Letunic et al. (2002) Nucleic Acids Res 30, 242-244), InterPro (Mulder et al., (2003) Nucl. Acids. Res. 31, 315-318), Prosite (Bucher and Bairoch (1994), A generalized profile syntax for biomolecular sequences motifs and its function in automatic sequence interpretation. (In) ISMB-94; Proceedings 2nd International Conference on Intelligent Systems for Molecular Biology. Altman R., Brutlag D., Karp P., Lathrop R., Searls D., Eds., pp 53-61, AAAI Press, Menlo Park; Hulo et al., Nucl. Acids. Res. 32:D134-D137, (2004)), or Pfam (Bateman et al., Nucleic Acids Research 30(1): 276-280 (2002)). A set of tools for in silico analysis of protein sequences is available on the ExPASy proteomics server (Swiss Institute of Bioinformatics (Gasteiger et al., ExPASy: the proteomics server for in-depth protein knowledge and analysis, Nucleic Acids Res. 31:3784-3788(2003)). Domains or motifs may also be identified using routine techniques, such as by sequence alignment. 
     Methods for the alignment of sequences for comparison are well known in the art, such methods include GAP, BESTFIT, BLAST, FASTA and TFASTA. GAP uses the algorithm of Needleman and Wunsch ((1970) J Mol Biol 48: 443-453) to find the global (i.e. spanning the complete sequences) alignment of two sequences that maximizes the number of matches and minimizes the number of gaps. The BLAST algorithm (Altschul et al. (1990) J Mol Biol 215: 403-10) calculates percent sequence identity and performs a statistical analysis of the similarity between the two sequences. The software for performing BLAST analysis is publicly available through the National Centre for Biotechnology Information (NCBI). Homologues may readily be identified using, for example, the ClustalW multiple sequence alignment algorithm (version 1.83), with the default pairwise alignment parameters, and a scoring method in percentage (See  FIG.  1   ). Global percentages of similarity and identity may also be determined using one of the methods available in the MatGAT software package (Campanella et al., BMC Bioinformatics. 2003 Jul. 10; 4:29. MatGAT: an application that generates similarity/identity matrices using protein or DNA sequences.). Minor manual editing may be performed to optimise alignment between conserved motifs, as would be apparent to a person skilled in the art. Furthermore, instead of using full-length sequences for the identification of homologues, specific domains may also be used. The sequence identity values may be determined over the entire nucleic acid or amino acid sequence or over selected domains or conserved motif(s), using the programs mentioned above using the default parameters. For local alignments, the Smith-Waterman algorithm is particularly useful (Smith T F, Waterman M S (1981) J. Mol. Biol 147(1); 195-7). 
     The proteins of the invention may be altered in various ways including amino acid substitutions, deletions, truncations, and insertions. Methods for such manipulations are generally known in the art. For example, amino acid sequence variants can be prepared by mutations in the DNA. Methods for mutagenesis and nucleotide sequence alterations are well known in the art. See, for example, Kunkel (1985) PNAS, 82:488-492; Kunkel et al. (1987) Methods in Enzymol. 154:367-382; U.S. Pat. No. 4,873,192; Walker and Gaastra, eds. (1983) Techniques in Molecular Biology (MacMillan Publishing Company, New York) and the references cited therein. Guidance as to appropriate amino acid substitutions that do not affect biological activity of the protein of interest may be found in the model of Dayhoff et al. (1978) Atlas of Protein Sequence and Structure (Natl. Biomed. Res. Found., Washington, D. C), herein incorporated by reference. Conservative substitutions, such as exchanging one amino acid with another having similar properties, may be preferable. 
     Alternatively, variant nucleotide sequences can be made by introducing mutations randomly along all or part of a coding sequence, such as by saturation mutagenesis, and the resultant mutants can be screened to identify mutants that encode proteins that retain activity. For example, following mutagenesis, the encoded protein can be expressed recombinantly, and the activity of the protein can be determined using standard assay techniques. 
     The inventors of the present invention have found that by substituting one or more of the key amino acid residues of the TriA enzyme of SEQ ID NO: 2, e.g. by employing one of the above described methods to mutate the TriA encoding nucleic acids, the tolerance or resistance to particular herbicides could be remarkably increased. Preferred substitutions of mutated TriA are those that increase the herbicide tolerance of the plant, but leave the biological activitiy of the deaminase activity substantially unaffected. 
     Accordingly, in another object of the present invention refers to a mutated TriA polypeptide, comprising the sequence of SEQ ID NO: 2, a variant, derivative, orthologue, paralogue or homologue thereof, the key amino acid residues of which is substituted by any other amino acid. 
     It will be understood by the person skilled in the art that amino acids located in a close proximity to the positions of amino acids mentioned below may also be substituted. Thus, in another embodiment the variant of SEQ ID NO: 2, a variant, derivative, orthologue, paralogue or homologue thereof comprises a mutated TriA, wherein an amino acid ±3, ±2 or ±1 amino acid positions from a key amino acid is substituted by any other amino acid. 
     Based on techniques well-known in the art, a highly characteristic sequence pattern can be developed, by means of which further of mutated TriA candidates with the desired activity may be searched. 
     Searching for further mutated TriA candidates by applying a suitable sequence pattern would also be encompassed by the present invention. It will be understood by a skilled reader that the present sequence pattern is not limited by the exact distances between two adjacent amino acid residues of said pattern. Each of the distances between two neighbours in the above patterns may, for example, vary independently of each other by up to ±10, ±5, ±3, ±2 or ±1 amino acid positions without substantially affecting the desired activity. 
     Furthermore, by applying the method of site directed mutagenesis, e.g. saturation mutagenes (see e.g. Schenk et al., Biospektrum 03/2006, pages 277-279), the inventors of the present invention have identified and generated specific amino acid subsitutions and combinations thereof, which—when introduced into a plant by transforming and expressing the respective mutated TriA encoding nucleic acid—confer increased herbicide resistance or tolerance to a herbicide to said plant. 
     Thus, in a particularly preferred embodiment, the variant or derivative of the mutated TriA refers to a TriA polypeptide comprising SEQ ID NO:2, a orthologue, paralogue, or homologue thereof, wherein the amino acid sequence differs from the wildtype amino acid sequence of a TriA polypeptide at one or more positions corresponding to the following positions of SEQ ID NO:2: 
     69, 70, 71, 74, 82, 84, 85, 87, 88, 89, 91, 92, 93, 96, 126, 128, 129, 130, 131, 155, 157, 160, 167, 170, 174, 180, 182, 216, 217, 219, 220, 246, 247, 248, 249, 250, 251, 298, 301, 302, 304, 328. 
     Examples of differences at these amino acid positions include, but are not limited to, one or more of the following: 
     the amino acid corresponding to position 69 is substituted by any other amino acid; 
     the amino acid corresponding to position 70 is substituted by any other amino acid; 
     the amino acid corresponding to position 71 is substituted by any other amino acid; 
     the amino acid corresponding to position 74 is substituted by any other amino acid; 
     the amino acid corresponding to position 82 is substituted by any other amino acid; 
     the amino acid corresponding to position 84 is substituted by any other amino acid; 
     the amino acid corresponding to position 85 is substituted by any other amino acid; 
     the amino acid corresponding to position 87 is substituted by any other amino acid; 
     the amino acid corresponding to position 88 is substituted by any other amino acid; 
     the amino acid corresponding to position 89 is substituted by any other amino acid; 
     the amino acid corresponding to position 91 is substituted by any other amino acid; 
     the amino acid corresponding to position 92 is substituted by any other amino acid; 
     the amino acid corresponding to position 93 is substituted by any other amino acid; 
     the amino acid corresponding to position 96 is substituted by any other amino acid; 
     the amino acid corresponding to position 126 is substituted by any other amino acid; 
     the amino acid corresponding to position 128 is substituted by any other amino acid; 
     the amino acid corresponding to position 129 is substituted by any other amino acid; 
     the amino acid corresponding to position 130 is substituted by any other amino acid; 
     the amino acid corresponding to position 131 is substituted by any other amino acid; 
     the amino acid corresponding to position 155 is substituted by any other amino acid; 
     the amino acid corresponding to position 157 is substituted by any other amino acid; 
     the amino acid corresponding to position 160 is substituted by any other amino acid; 
     the amino acid corresponding to position 167 is substituted by any other amino acid; 
     the amino acid corresponding to position 170 is substituted by any other amino acid; 
     the amino acid corresponding to position 174 is substituted by any other amino acid; 
     the amino acid corresponding to position 180 is substituted by any other amino acid; 
     the amino acid corresponding to position 182 is substituted by any other amino acid; 
     the amino acid corresponding to position 216 is substituted by any other amino acid; 
     the amino acid corresponding to position 217 is substituted by any other amino acid; 
     the amino acid corresponding to position 219 is substituted by any other amino acid; 
     the amino acid corresponding to position 220 is substituted by any other amino acid; 
     the amino acid corresponding to position 246 is substituted by any other amino acid; 
     the amino acid corresponding to position 247 is substituted by any other amino acid; 
     the amino acid corresponding to position 248 is substituted by any other amino acid; 
     the amino acid corresponding to position 249 is substituted by any other amino acid; 
     the amino acid corresponding to position 250 is substituted by any other amino acid; 
     the amino acid corresponding to position 251 is substituted by any other amino acid; 
     the amino acid corresponding to position 298 is substituted by any other amino acid; 
     the amino acid corresponding to position 301 is substituted by any other amino acid; 
     the amino acid corresponding to position 302 is substituted by any other amino acid; 
     the amino acid corresponding to position 304 is substituted by any other amino acid; 
     the amino acid corresponding to position 328 is substituted by any other amino acid; 
     Examples of differences at these amino acid positions include, but are not limited to, one or more of the following: 
     the amino acid corresponding to position 69 is other than Valine; 
     the amino acid corresponding to position 70 is other than Asparagine; 
     the amino acid corresponding to position 71 is other than Glutamine; 
     the amino acid corresponding to position 74 is other than Leucine; 
     the amino acid corresponding to position 82 is other than Arginine; 
     the amino acid corresponding to position 84 is other than Leucine; 
     the amino acid corresponding to position 85 is other than Tyrosine; 
     the amino acid corresponding to position 87 is other than Tryptophan; 
     the amino acid corresponding to position 88 is other than Leucine; 
     the amino acid corresponding to position 89 is other than Phenylalanine; 
     the amino acid corresponding to position 91 is other than Valine; 
     the amino acid corresponding to position 92 is other than Leucine; 
     the amino acid corresponding to position 93 is other than Tyrosine; 
     the amino acid corresponding to position 96 is other than Glutamine; 
     the amino acid corresponding to position 126 is other than Asparagine; 
     the amino acid corresponding to position 128 is other than Aspartic Acid; 
     the amino acid corresponding to position 129 is other than Serine; 
     the amino acid corresponding to position 130 is other than Alanine; 
     the amino acid corresponding to position 131 is other than Isoleucine; 
     the amino acid corresponding to position 155 is other than Methionine; 
     the amino acid corresponding to position 157 is other than Phenylalanine; 
     the amino acid corresponding to position 160 is other than Methionine; 
     the amino acid corresponding to position 167 is other than Tyrosine; 
     the amino acid corresponding to position 170 is other than Alanine; 
     the amino acid corresponding to position 174 is other than Lysine; 
     the amino acid corresponding to position 180 is other than Leucine; 
     the amino acid corresponding to position 182 is other than Serine; 
     the amino acid corresponding to position 216 is other than Alanine; 
     the amino acid corresponding to position 217 is other than Isoleucine; 
     the amino acid corresponding to position 219 is other than Proline; 
     the amino acid corresponding to position 220 is other than Alanine; 
     the amino acid corresponding to position 246 is other than Glutamate; 
     the amino acid corresponding to position 247 is other than Serine; 
     the amino acid corresponding to position 248 is other than Aspartate; 
     the amino acid corresponding to position 249 is other than Histidine; 
     the amino acid corresponding to position 250 is other than Aspartate; 
     the amino acid corresponding to position 251 is other than Glutamate; 
     the amino acid corresponding to position 298 is other than Glutamine; 
     the amino acid corresponding to position 301 is other than Serine; 
     the amino acid corresponding to position 302 is other than Asparagine; 
     the amino acid corresponding to position 304 is other than Tyrosine; 
     the amino acid corresponding to position 328 is other than Aspartate; 
     In a preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: the amino acid corresponding to position 70 is Thr, Cys, Gly, Val, or Ser. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: the amino acid corresponding to position 71 is Thr, Val, Gly, Cys, or Ser. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 70 is Val, and the amino acid corresponding to position 71 is Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 70 is Val, and the amino acid corresponding to position 71 is Thr. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 70 is Thr, and the amino acid corresponding to position 71 is Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 70 is Thr, and the amino acid corresponding to position 71 is Thr. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 155 is Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: the amino acid corresponding to position 128 is Gly, Pro, or Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: the amino acid corresponding to position 70 is Val, and the amino acid corresponding to position 155 is Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: the amino acid corresponding to position 70 is Val, and the amino acid corresponding to position 155 is Val, and the amino acid corresponding to position 128 is Ser. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: the amino acid corresponding to position 70 is Val, and the amino acid corresponding to position 155 is Val, and the amino acid corresponding to position 128 is Thr. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: the amino acid corresponding to position 157 is Thr, Ala, Met or Ser. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 157 is Ala, and the amino acid corresponding to position 70 is Leu, and the amino acid corresponding to position 71 is Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 157 is Ala, and the amino acid corresponding to position 70 is Ile, and the amino acid corresponding to position 71 is Ile. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 88 is Val, and the amino acid corresponding to position 92 is Ile. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 88 is Val, and the amino acid corresponding to position 92 is Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 157 is Val, and the amino acid corresponding to position 88 is Val, and the amino acid corresponding to position 92 is Ile. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 157 is Ala, and the amino acid corresponding to position 88 is Val, and the amino acid corresponding to position 92 is Ile. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 96 is Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Val, and the amino acid corresponding to position 92 is Val, and the amino acid corresponding to position 155 is Ala, and the amino acid corresponding to position 157 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 128 is Ile, and the amino acid corresponding to position 155 is Val, and the amino acid corresponding to position 70 is Leu, and the amino acid corresponding to position 71 is Ile. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Leu, and the amino acid corresponding to position 91 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Leu, and the amino acid corresponding to position 91 is Ala, and the amino acid corresponding to position 92 is Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Leu, and the amino acid corresponding to position 91 is Ala, and the amino acid corresponding to position 92 is Val, and the amino acid corresponding to position 88 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 88 is Ala, and the amino acid corresponding to position 157 is Ile. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 88 is Ala, and the amino acid corresponding to position 157 is Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 69 is Ala, Leu, or Ser. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 74 is Val, or Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 74 is Ala, and the amino acid corresponding to position 70 is Leu, and the amino acid corresponding to position 71 is Ile. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 82 is Leu, Met, or Gly. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 96 is Glu, Asp, Ala, Thr or Asn. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 126 is Ala, Met, Ser, or Asp. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 128 is Ser, Ala, or Asn. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 155 is Gly, Ala, or Glu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 157 is Met, or Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 167 is Ile, and the amino acid corresponding to position 88 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 167 is Ile, and the amino acid corresponding to position 88 is Ala, and the amino acid corresponding to position 84 is Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 167 is Ile, and the amino acid corresponding to position 88 is Ala, and the amino acid corresponding to position 84 is Thr. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 216 is Ser, or Gly. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 217 is Ala, Ser, or Thr. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 219 is Gly, and the amino acid corresponding to position 249 is Asn. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 219 is Gly, and the amino acid corresponding to position 249 is Asn, and the amino acid corresponding to position 217 is Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 220 is Thr, Ser, or Gly. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 220 is Gly, and the amino acid corresponding to position 157 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 246 is Ser, Thr, Gln, or Asp. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 247 is Ala, Asn, Val, Gly, or Pro. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 248 is Ser, Asn, or Gly. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 249 is Val, Ile, or Asn. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 250 is Glu, or Asn. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 251 is Asp. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 251 is Asp, and the amino acid corresponding to position 248 is Glu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 298 is Cys, Asn, Thr, or Ser. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 301 is Ala, Thr, or Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 302 is Glu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 304 is Lys. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 87 is Thr. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 88 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Phe. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 128 is Gly. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 128 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 88 is Ala, and the amino acid corresponding to position 93 is Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 88 is Ala, and the amino acid corresponding to position 93 is Phe. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 88 is Ala, and the amino acid corresponding to position 128 is Gly. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 88 is Ala, and the amino acid corresponding to position 128 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Phe, and the amino acid corresponding to position 128 is Gly. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Phe, and the amino acid corresponding to position 128 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 155 is Thr, and the amino acid corresponding to position 157 is Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 155 is Thr, and the amino acid corresponding to position 157 is Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 155 is Val, and the amino acid corresponding to position 157 is Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 155 is Val, and the amino acid corresponding to position 157 is Val. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 328 is Gly. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 89 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 89 is Ala, and the amino acid corresponding to position 93 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 89 is Ala, and the amino acid corresponding to position 93 is Ala, and the amino acid corresponding to position 160 is Gly. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Phe. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 89 is Ala, Val, or Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 93 is Ala, Val, Leu, or Phe. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 217 is Gly. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 160 is Gly. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 250 is Ser. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 328 is Gly, or Ala. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     The amino acid corresponding to position 129 and/or position 130 is deleted. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     The amino acid corresponding to position 130 and/or position 131 is deleted. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     The amino acid corresponding to position 170 and/or position 182 is deleted. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     The amino acid corresponding to position 174 and/or position 180 is deleted. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 89 is Ala, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 89 is Leu, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 85 is Leu, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Leu. 
     In another preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 85 is Leu, and the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Val. 
     In a particularly preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Val, and the amino acid corresponding to position 155 is Thr, and the amino acid corresponding to position 157 is Leu. 
     In another particularly preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Leu, and the amino acid corresponding to position 155 is Thr, and the amino acid corresponding to position 157 is Leu. 
     In another particularly preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Leu, and the amino acid corresponding to position 155 is Val, and the amino acid corresponding to position 157 is Leu. 
     In another particularly preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Leu, and the amino acid corresponding to position 157 is Leu. 
     In another particularly preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Phe, and the amino acid corresponding to position 96 is Thr, and the amino acid corresponding to position 128 is Gly. 
     In another particularly preferred embodiment, the mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 71 is Asn, the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Leu, and the amino acid corresponding to position 96 is Thr, and the amino acid corresponding to position 128 is Gly. 
     Other preferred embodiments, i.e. combinations of mutations are shown in the following Table 1. 
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                   
                 amino 
                   
                 amino 
                   
                 amino 
                   
                 amino 
                   
                 amino 
                   
                 amino 
                   
                 amino 
                   
                 amino 
                   
                 amino 
                   
               
               
                   
                 acid 
                   
                 acid 
                   
                 acid 
                   
                 acid 
                   
                 acid 
                   
                 acid 
                   
                 acid 
                   
                 acid 
                   
                 acid 
                   
               
               
                   
                 posi- 
                   
                 posi- 
                   
                 posi- 
                   
                 posi- 
                   
                 posi- 
                   
                 posi- 
                   
                 posi- 
                   
                 posi- 
                   
                 posi- 
                   
               
               
                   
                 tion  
                 pre- 
                 tion  
                 pre- 
                 tion  
                 pre- 
                 tion  
                 pre- 
                 tion  
                 pre- 
                 tion  
                 pre- 
                 tion  
                 pre- 
                 tion  
                 pre- 
                 tion  
                 pre- 
               
               
                   
                 in 
                 ferred 
                 in 
                 ferred 
                 in 
                 ferred 
                 in 
                 ferred 
                 in 
                 ferred 
                 in 
                 ferred 
                 in 
                 ferred 
                 in 
                 ferred 
                 in 
                 ferred 
               
               
                 Com- 
                 SEQ 
                 sub- 
                 SEQ 
                 sub- 
                 SEQ 
                 sub- 
                 SEQ 
                 sub- 
                 SEQ 
                 sub- 
                 SEQ 
                 sub- 
                 SEQ 
                 sub- 
                 SEQ 
                 sub- 
                 SEQ 
                 sub- 
               
               
                 bina- 
                 ID 
                 stitu- 
                 ID 
                 stitu- 
                 ID 
                 stitu- 
                 ID 
                 stitu- 
                 ID 
                 stitu- 
                 ID 
                 stitu- 
                 ID 
                 stitu- 
                 ID 
                 stitu- 
                 ID 
                 stitu- 
               
               
                 tion 
                 NO: 2 
                 tion 
                 NO: 2 
                 tion 
                 NO: 2 
                 tion 
                 NO: 2 
                 tion 
                 NO: 2 
                 tion 
                 NO: 2 
                 tion 
                 NO: 2 
                 tion 
                 NO: 2 
                 tion 
                 NO: 2 
                 tion 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1 
                 Q71 
                 V 
                 L92 
                 V 
                 M155 
                 A 
                 F157 
                 A 
                 N70 
                 V 
                   
               
               
                 2 
                 Q71 
                 V 
                 L92 
                 V 
                 M155 
                 A 
                 F157 
                 A 
                 N70 
                 1 
                   
               
               
                 3 
                 D128 
                 1 
                 M155 
                 V 
                 N70 
                 L 
                 Q71 
                 1 
                 F157 
                 L 
                   
               
               
                 4 
                 Q71 
                 L 
                 V91 
                 A 
                 L92 
                 V 
                 L88 
                 A 
                 F157 
                 L 
                   
               
               
                 5 
                 Q71 
                 N 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 L 
                 1217 
                 A 
                   
               
               
                 6 
                 Q71 
                 N 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 F 
                 F157 
                 L 
                   
               
               
                 7 
                 Q71 
                 N 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 F 
                 D128 
                 G 
                   
               
               
                 8 
                 Q71 
                 N 
                 L92 
                 A 
                 Y93 
                 F 
                 D128 
                 G 
                 Q96 
                 T 
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 9 
                 Y85 
                 L 
                 F89 
                 A 
                 L92 
                 A 
                 Y93 
                 L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 10 
                 Y85 
                 L 
                 L92 
                 A 
                 Y93 
                 L 
                 D250 
                 S 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 11 
                 Y85 
                 L 
                 L92 
                 A 
                 Y93 
                 L 
                 D128 
                 A 
                 D250 
                 S 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 12 
                 L92 
                 A 
                 Y93 
                 L 
                 D250 
                 S 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 13 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 14 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 V 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 15 
                 Y85 
                 L 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 16 
                 Y85 
                 L 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 V 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 17 
                 Y85 
                 L 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 L 
                 D128 
                 G 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 18 
                 Y85 
                 L 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 V 
                 D128 
                 G 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 19 
                 Y85 
                 L 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 L 
                 Q96 
                 T 
                 D128 
                 G 
                   
                   
                   
                   
                   
                   
               
               
                 20 
                 Y85 
                 L 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 V 
                 Q96 
                 T 
                 D128 
                 G 
                   
                   
                   
                   
                   
                   
               
               
                 21 
                 Y85 
                 L 
                 L88 
                 A 
                 F89 
                 A 
                 L92 
                 A 
                 Y93 
                 L 
                 Q96 
                 T 
                 D128 
                 G 
                   
                   
                   
                   
               
               
                 22 
                 Y85 
                 L 
                 L88 
                 A 
                 F89 
                 A 
                 L92 
                 A 
                 Y93 
                 V 
                 Q96 
                 T 
                 D128 
                 G 
                   
                   
                   
                   
               
               
                 23 
                 Q71 
                 N 
                 L92 
                 A 
                 Y93 
                 L 
                 Q96 
                 T 
                 D128 
                 G 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 24 
                 L92 
                 A 
                 Y93 
                 L 
                 Q96 
                 T 
                 D128 
                 G 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 25 
                 L92 
                 A 
                 Y93 
                 V 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 26 
                 L92 
                 A 
                 Y93 
                 I 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 27 
                 L92 
                 A 
                 Y93 
                 V 
                 M155 
                 T 
                 F157 
                 L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 28 
                 L92 
                 A 
                 Y93 
                 L 
                 M155 
                 T 
                 F157 
                 L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 29 
                 L92 
                 A 
                 Y93 
                 L 
                 F157 
                 L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 30 
                 L88 
                 A 
                 L92 
                 A 
                 Y93 
                 L 
                 F157 
                 L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 31 
                 W87 
                 F 
                 L92 
                 A 
                 Y93 
                 L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 32 
                 W87 
                 H 
                 L92 
                 A 
                 Y93 
                 L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 33 
                 W87 
                 A 
                 L92 
                 A 
                 Y93 
                 L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 34 
                 Y85 
                 L 
                 L88 
                 A 
                 F89 
                 A 
                 L92 
                 A 
                 Y93 
                 L 
                 Q96 
                 T 
                 D128 
                 G 
                 M155 
                 V 
                 F157 
                 L 
               
               
                 35 
                 Y85 
                 L 
                 L88 
                 A 
                 F89 
                 A 
                 L92 
                 A 
                 Y93 
                 V 
                 Q96 
                 T 
                 D128 
                 G 
                 M155 
                 V 
                 F157 
                 L 
               
               
                   
               
            
           
         
       
     
     It will be within the knowledge of the skilled artisan to identify conserved regions and motifs shared between the homologues, orthologues and paralogues encoded by SEQ ID NO: 1. Having identified such conserved regions that may represent suitable binding motifs, amino acids can be chosen to be subsituted by any other amino acid, for example by conserved amino acids, preferably by the amino acid substitutions described SUPRA using SEQ ID NO:2 as reference. 
     Another object refers to a method of identifying a nucleotide sequence encoding a mutated TriA which is resistant or tolerant to a herbicide, the method comprising:
     a) generating a library of mutated TriA-encoding nucleic acids,   b) screening a population of the resulting mutated TriA-encoding nucleic acids by expressing each of said nucleic acids in a cell or plant and treating said cell or plant with a herbicide,   c) comparing the herbicide-tolerance levels provided by said population of mutated TriA encoding nucleic acids with the herbicide-tolerance level provided by a control TriA-encoding nucleic acid,   d) selecting at least one mutated TriA-encoding nucleic acid that provides a significantly increased level of tolerance to a herbicide as compared to that provided by the control TriA-encoding nucleic acid.   

     Herbicide-tolerance levels may also be determined by measuring the detoxification rate in a cell, tissue, or plant. 
     Detoxification rate is the rate of herbicide degradation within a certain timeframe in a respective tissue. The degradation and product formation can be determined analytically for instance by liquid chromatographie (LC) coupled to a high resolution (HR) mass spectromter (MS). Product can be determined by comparison to authentic standards and/or by structure elucidation. 
     In a preferred embodiment, the mutated TriA-encoding nucleic acid selected in step d) provides at least 2-fold as much resistance or tolerance of a cell or plant to a herbicide as compared to that provided by the control TriA-encoding nucleic acid. 
     In a further preferred embodiment, the mutated TriA-encoding nucleic acid selected in step d) provides at least 2-fold, at least 5-fold, at least 10-fold, at least 20-fold, at least 50-fold, at least 100-fold, at least 500-fold, as much resistance or tolerance of a cell or plant to a herbicide as compared to that provided by the control TriA-encoding nucleic acid. 
     The resistance or tolerance can be determined by generating a transgenic plant or host cell, preferably a plant cell, comprising a nucleic acid sequence of the library of step a) and comparing said transgenic plant with a control plant or host cell, preferably a plant cell. 
     Many methods well known to the skilled artisan are available for obtaining suitable candidate nucleic acids for identifying a nucleotide sequence encoding a mutated TriA from a variety of different potential source organisms including microbes, plants, fungi, algae, mixed cultures etc. as well as environmental sources of DNA such as soil. These methods include inter alia the preparation of cDNA or genomic DNA libraries, the use of suitably degenerate oligonucleotide primers, the use of probes based upon known sequences or complementation assays (for example, for growth upon tyrosine) as well as the use of mutagenesis and shuffling in order to provide recombined or shuffled mutated TriA-encoding sequences. 
     Nucleic acids comprising candidate and control TriA encoding sequences can be expressed in yeast, in a bacterial host strain, in an alga or in a higher plant such as tobacco or  Arabidopsis  and the relative levels of inherent tolerance of the TriA encoding sequences screened according to a visible indicator phenotype of the transformed strain or plant in the presence of different concentrations of the selected herbicide. Dose responses and relative shifts in dose responses associated with these indicator phenotypes (formation of brown color, growth inhibition, herbicidal effect etc) are conveniently expressed in terms, for example, of GR50 (concentration for 50% reduction of growth) or MIC (minimum inhibitory concentration) values where increases in values correspond to increases in inherent tolerance of the expressed TriA. For example, in a relatively rapid assay system based upon transformation of a bacterium such as  E. coli , each mutated TriA encoding sequence may be expressed, for example, as a DNA sequence under expression control of a controllable promoter such as the lacZ promoter and taking suitable account, for example by the use of synthetic DNA, of such issues as codon usage in order to obtain as comparable a level of expression as possible of different TriA sequences. Such strains expressing nucleic acids comprising alternative candidate TriA sequences may be plated out on different concentrations of the selected herbicide in, optionally, a tyrosine supplemented medium and the relative levels of inherent tolerance of the expressed TriA enzymes estimated on the basis of the extent and MIC for inhibition of the formation of the brown, ochronotic pigment, or by measuring the herbicide degradation via LC-HRMS (liquid chromatography high resolution mass spectrometry). 
     In another embodiment, candidate nucleic acids are transformed into plant material to generate a transgenic plant, regenerated into morphologically normal fertile plants which are then measured for differential tolerance to selected herbicides as described in the Example section hereinafter. Many suitable methods for transformation using suitable selection markers such as kanamycin, binary vectors such as from  Agrobacterium  and plant regeneration as, for example, from tobacco leaf discs are well known in the art. Optionally, a control population of plants is likewise transformed with a nucleic acid expressing the control TriA. The average, and distribution, of herbicide tolerance levels of a range of primary plant transformation events or their progeny to herbicides described supra are evaluated in the normal manner based upon plant damage, meristematic bleaching symptoms etc. at a range of different concentrations of herbicides. These data can be expressed in terms of, for example, GR50 values derived from dose/response curves having “dose” plotted on the x-axis and “percentage kill”, “herbicidal effect”, “numbers of emerging green plants” etc. plotted on the y-axis where increased GR50 values correspond to increased levels of inherent tolerance of the expressed TriA. Herbicides can suitably be applied pre-emergence or post-emergence. 
     Another object of the present invention refers to an isolated, recombinant and/or chemically synthesized nucleic acid encoding a mutated TriA as disclosed SUPRA, wherein the nucleic acid comprises the nucleotide sequence of SEQ ID NO: 1, or a variant or derivative thereof. 
     Examples of differences at these amino acid positions include, but are not limited to, one or more of the following: 
     the amino acid corresponding to position 69 is substituted by any other amino acid; 
     the amino acid corresponding to position 70 is substituted by any other amino acid; 
     the amino acid corresponding to position 71 is substituted by any other amino acid; 
     the amino acid corresponding to position 74 is substituted by any other amino acid; 
     the amino acid corresponding to position 82 is substituted by any other amino acid; 
     the amino acid corresponding to position 84 is substituted by any other amino acid; 
     the amino acid corresponding to position 85 is substituted by any other amino acid; 
     the amino acid corresponding to position 87 is substituted by any other amino acid; 
     the amino acid corresponding to position 88 is substituted by any other amino acid; 
     the amino acid corresponding to position 89 is substituted by any other amino acid; 
     the amino acid corresponding to position 91 is substituted by any other amino acid; 
     the amino acid corresponding to position 92 is substituted by any other amino acid; 
     the amino acid corresponding to position 93 is substituted by any other amino acid; 
     the amino acid corresponding to position 96 is substituted by any other amino acid; 
     the amino acid corresponding to position 126 is substituted by any other amino acid; 
     the amino acid corresponding to position 128 is substituted by any other amino acid; 
     the amino acid corresponding to position 129 is substituted by any other amino acid; 
     the amino acid corresponding to position 130 is substituted by any other amino acid; 
     the amino acid corresponding to position 131 is substituted by any other amino acid; 
     the amino acid corresponding to position 155 is substituted by any other amino acid; 
     the amino acid corresponding to position 157 is substituted by any other amino acid; 
     the amino acid corresponding to position 160 is substituted by any other amino acid; 
     the amino acid corresponding to position 167 is substituted by any other amino acid; 
     the amino acid corresponding to position 170 is substituted by any other amino acid; 
     the amino acid corresponding to position 174 is substituted by any other amino acid; 
     the amino acid corresponding to position 180 is substituted by any other amino acid; 
     the amino acid corresponding to position 182 is substituted by any other amino acid; 
     the amino acid corresponding to position 216 is substituted by any other amino acid; 
     the amino acid corresponding to position 217 is substituted by any other amino acid; 
     the amino acid corresponding to position 219 is substituted by any other amino acid; 
     the amino acid corresponding to position 220 is substituted by any other amino acid; 
     the amino acid corresponding to position 246 is substituted by any other amino acid; 
     the amino acid corresponding to position 247 is substituted by any other amino acid; 
     the amino acid corresponding to position 248 is substituted by any other amino acid; 
     the amino acid corresponding to position 249 is substituted by any other amino acid; 
     the amino acid corresponding to position 250 is substituted by any other amino acid; 
     the amino acid corresponding to position 251 is substituted by any other amino acid; 
     the amino acid corresponding to position 298 is substituted by any other amino acid; 
     the amino acid corresponding to position 301 is substituted by any other amino acid; 
     the amino acid corresponding to position 302 is substituted by any other amino acid; 
     the amino acid corresponding to position 304 is substituted by any other amino acid; 
     the amino acid corresponding to position 328 is substituted by any other amino acid; 
     In a preferred embodiment, the encoded mutated TriA is a variant of SEQ ID NO:2, which includes one or more of the following: 
     the amino acid corresponding to position 69 is other than Valine; 
     the amino acid corresponding to position 70 is other than Asparagine; 
     the amino acid corresponding to position 71 is other than Glutamine; 
     the amino acid corresponding to position 74 is other than Leucine; 
     the amino acid corresponding to position 82 is other than Arginine; 
     the amino acid corresponding to position 84 is other than Leucine; 
     the amino acid corresponding to position 85 is other than Tyrosine; 
     the amino acid corresponding to position 87 is other than Tryptophan; 
     the amino acid corresponding to position 88 is other than Leucine; 
     the amino acid corresponding to position 89 is other than Phenylalanine; 
     the amino acid corresponding to position 91 is other than Valine; 
     the amino acid corresponding to position 92 is other than Leucine; 
     the amino acid corresponding to position 93 is other than Tyrosine; 
     the amino acid corresponding to position 96 is other than Glutamine; 
     the amino acid corresponding to position 126 is other than Asparagine; 
     the amino acid corresponding to position 128 is other than Aspartic Acid; 
     the amino acid corresponding to position 129 is other than Serine; 
     the amino acid corresponding to position 130 is other than Alanine; 
     the amino acid corresponding to position 131 is other than Isoleucine; 
     the amino acid corresponding to position 155 is other than Methionine; 
     the amino acid corresponding to position 157 is other than Phenylalanine; 
     the amino acid corresponding to position 160 is other than Methionine; 
     the amino acid corresponding to position 167 is other than Tyrosine; 
     the amino acid corresponding to position 170 is other than Alanine; 
     the amino acid corresponding to position 174 is other than Lysine; 
     the amino acid corresponding to position 180 is other than Leucine; 
     the amino acid corresponding to position 182 is other than Serine; 
     the amino acid corresponding to position 216 is other than Alanine; 
     the amino acid corresponding to position 217 is other than Isoleucine; 
     the amino acid corresponding to position 219 is other than Proline; 
     the amino acid corresponding to position 220 is other than Alanine; 
     the amino acid corresponding to position 246 is other than Glutamate; 
     the amino acid corresponding to position 247 is other than Serine; 
     the amino acid corresponding to position 248 is other than Aspartate; 
     the amino acid corresponding to position 249 is other than Histidine; 
     the amino acid corresponding to position 250 is other than Aspartate; 
     the amino acid corresponding to position 251 is other than Glutamate; 
     the amino acid corresponding to position 298 is other than Glutamine; 
     the amino acid corresponding to position 301 is other than Serine; 
     the amino acid corresponding to position 302 is other than Asparagine; 
     the amino acid corresponding to position 304 is other than Tyrosine; 
     the amino acid corresponding to position 328 is other than Aspartate; 
     In a particularly preferred embodiment, the mutated TriA encoded by the nucleic acid of the present invention comprises a variant of SEQ ID NO: 2 in which the amino acids at positions corresponding to positions 92, 93, 155, and 157 of SEQ ID NO:2 are substituted by any other amino acid. 
     In a particularly preferred embodiment, the encoded mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Val, and the amino acid corresponding to position 155 is Thr, and the amino acid corresponding to position 157 is Leu. 
     In another particularly preferred embodiment, the encoded mutated TriA comprises a sequence of SEQ ID NO: 2 a variant, derivative, orthologue, paralogue of homologue therof, in which: 
     the amino acid corresponding to position 92 is Ala, and the amino acid corresponding to position 93 is Leu, and the amino acid corresponding to position 155 is Thr, and the amino acid corresponding to position 157 is Leu. 
     In other aspects, the present invention encompasses a progeny or a descendant of a herbicide-tolerant plant of the present invention as well as seeds derived from the herbicide-tolerant plants of the invention and cells derived from the herbicide-tolerant plants of the invention. 
     In some embodiments, the present invention provides a progeny or descendant plant derived from a plant comprising in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, wherein the progeny or descendant plant comprises in at least some of its cells the recombinant polynucleotide operably linked to the promoter, the expression of the mutated TriA polypeptide conferring to the progeny or descendant plant tolerance to the herbicides. 
     In one embodiment, seeds of the present invention preferably comprise the herbicide-tolerance characteristics of the herbicide-tolerant plant. In other embodiments, a seed is capable of germination into a plant comprising in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the progeny or descendant plant tolerance to the herbicides. 
     In some embodiments, plant cells of the present invention are capable of regenerating a plant or plant part. In other embodiments, plant cells are not capable of regenerating a plant or plant part. Examples of cells not capable of regenerating a plant include, but are not limited to, endosperm, seed coat (testa &amp; pericarp), and root cap. 
     In another embodiment, the present invention provides a plant cell of or capable of regenerating a plant comprising in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to the herbicides, wherein the plant cell comprises the recombinant polynucleotide operably linked to a promoter. 
     In other embodiments, the present invention provides a plant cell comprising a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the cell tolerance to the herbicides. 
     In another embodiment, the invention refers to a plant cell transformed by a nucleic acid encoding a mutated TriA polypeptide according to the present invention, wherein expression of the nucleic acid in the plant cell results in increased resistance or tolerance to a herbicide as compared to a wild type variety of the plant cell. Preferably, the mutated TriA polypeptide encoding nucleic acid comprises a polynucleotide sequence selected from the group consisting of: a) a polynucleotide as shown in SEQ ID NO: 1, or a variant or derivative thereof; b) a polynucleotide encoding a polypeptide as shown in SEQ ID NO: 2, or a variant or derivative thereof; c) a polynucleotide comprising at least 60 consecutive nucleotides of any of a) or b); and d) a polynucleotide complementary to the polynucleotide of any of a) through c). 
     In some aspects, the present invention provides a plant product prepared from the herbicide-tolerant plants hereof. In some embodiments, examples of plant products include, without limitation, grain, oil, and meal. In one embodiment, a plant product is plant grain (e.g., grain suitable for use as feed or for processing), plant oil (e.g., oil suitable for use as food or biodiesel), or plant meal (e.g., meal suitable for use as feed). 
     In one embodiment, a plant product prepared from a plant or plant part is provided, wherein the plant or plant part comprises in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the a plant or plant part tolerance to the herbicides. 
     In another embodiment, the invention refers to a method of producing a transgenic plant cell with an increased resistance to a herbicide as compared to a wild type variety of the plant cell comprising, transforming the plant cell with an expression cassette comprising a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide. 
     In another embodiment, the invention refers to a method of producing a transgenic plant comprising, (a) transforming a plant cell with an expression cassette comprising a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, and (b) generating a plant with an increased resistance to herbicide from the plant cell. 
     In some aspects, the present invention provides a method for producing a herbicide-tolerant plant. In one embodiment, the method comprises: regenerating a plant from a plant cell transformed with a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to the herbicides. 
     The term “expression/expressing” or “gene expression” means the transcription of a specific gene or specific genes or specific genetic construct. The term “expression” or “gene expression” in particular means the transcription of a gene or genes or genetic construct into structural RNA (rRNA, tRNA) or mRNA with or without subsequent translation of the latter into a protein. The process includes transcription of DNA and processing of the resulting mRNA product. 
     To obtain the desired effect, i.e. plants that are tolerant or resistant to the herbicide derivative herbicide of the present invention, it will be understood that the at least one nucleic acid is “over-expressed” by methods and means known to the person skilled in the art. 
     The term “increased expression” or “overexpression” as used herein means any form of expression that is additional to the wild-type expression level. Methods for increasing expression of genes or gene products are well documented in the art and include, for example, overexpression driven by appropriate promoters, the use of transcription enhancers or translation enhancers. Isolated nucleic acids which serve as promoter or enhancer elements may be introduced in an appropriate position (typically upstream) of a non-heterologous form of a polynucleotide so as to upregulate expression of a nucleic acid encoding the polypeptide of interest. For example, endogenous promoters may be altered in vivo by mutation, deletion, and/or substitution (see, Kmiec, U.S. Pat. No. 5,565,350; Zarling et al., WO9322443), or isolated promoters may be introduced into a plant cell in the proper orientation and distance from a gene of the present invention so as to control the expression of the gene. If polypeptide expression is desired, it is generally desirable to include a polyadenylation region at the 3′-end of a polynucleotide coding region. The polyadenylation region can be derived from the natural gene, from a variety of other plant genes, or from T-DNA. The 3′ end sequence to be added may be derived from, for example, the nopaline synthase or octopine synthase genes, or alternatively from another plant gene, or less preferably from any other eukaryotic gene. An intron sequence may also be added to the 5′ untranslated region (UTR) or the coding sequence of the partial coding sequence to increase the amount of the mature message that accumulates in the cytosol. Inclusion of a spliceable intron in the transcription unit in both plant and animal expression constructs has been shown to increase gene expression at both the mRNA and protein levels up to 1000-fold (Buchman and Berg (1988) Mol. Cell biol. 8: 4395-4405; Callis et al. (1987) Genes Dev 1:1183-1200). Such intron enhancement of gene expression is typically greatest when placed near the 5′ end of the transcription unit. Use of the maize introns Adh1-S intron 1, 2, and 6, the Bronze-1 intron are known in the art. For general information see: The Maize Handbook, Chapter 116, Freeling and Walbot, Eds., Springer, N.Y. (1994). 
     Where appropriate, nucleic acid sequences may be optimized for increased expression in a transformed plant. For example, coding sequences that comprise plant-preferred codons for improved expression in a plant can be provided. See, for example, Campbell and Gowri (1990) Plant Physiol., 92: 1-11 for a discussion of host-preferred codon usage. Methods also are known in the art for preparing plant-preferred genes. See, for example, U.S. Pat. Nos. 5,380,831, and 5,436,391, and Murray et al. (1989) Nucleic Acids Res. 17:477-498, herein incorporated by reference. 
     Consequently, wildtype/mutated TriA nucleic acids of the invention are provided in expression cassettes for expression in the plant of interest. The cassette will include regulatory sequences operably linked to a mutated TriA nucleic acid sequence of the invention. The term “regulatory element” as used herein refers to a polynucleotide that is capable of regulating the transcription of an operably linked polynucleotide. It includes, but not limited to, promoters, enhancers, introns, 5′ UTRs, and 3′ UTRs. By “operably linked” is intended a functional linkage between a promoter and a second sequence, wherein the promoter sequence initiates and mediates transcription of the DNA sequence corresponding to the second sequence. Generally, operably linked means that the nucleic acid sequences being linked are contiguous and, where necessary to join two protein coding regions, contiguous and in the same reading frame. The cassette may additionally contain at least one additional gene to be cotransformed into the organism. Alternatively, the additional gene(s) can be provided on multiple expression cassettes. 
     Such an expression cassette is provided with a plurality of restriction sites for insertion of the wildtype/mutated TriA nucleic acid sequence to be under the transcriptional regulation of the regulatory regions. The expression cassette may additionally contain selectable marker genes. The expression cassette of the present invention will include in the 5′-3′ direction of transcription, a transcriptional and translational initiation region (i.e., a promoter), a wildtype/mutated TriA encoding nucleic acid sequence of the invention, and a transcriptional and translational termination region (i.e., termination region) functional in plants. The promoter may be native or analogous, or foreign or heterologous, to the plant host and/or to the wildtype/mutated TriA nucleic acid sequence of the invention. Additionally, the promoter may be the natural sequence or alternatively a synthetic sequence. Where the promoter is “foreign” or “heterologous” to the plant host, it is intended that the promoter is not found in the native plant into which the promoter is introduced. Where the promoter is “foreign” or “heterologous” to the wildtype/mutated TriA nucleic acid sequence of the invention, it is intended that the promoter is not the native or naturally occurring promoter for the operably linked wildtype/mutatedTriA nucleic acid sequence of the invention. As used herein, a chimeric gene comprises a coding sequence operably linked to a transcription initiation region that is heterologous to the coding sequence. While it may be preferable to express the wildtype/mutated TriA nucleic acids of the invention using heterologous promoters, the native promoter sequences may be used. Such constructs would change expression levels of the wildtype/mutated TriA protein in the plant or plant cell. Thus, the phenotype of the plant or plant cell is altered. 
     The termination region may be native with the transcriptional initiation region, may be native with the operably linked wildtype/mutated TriA sequence of interest, may be native with the plant host, or may be derived from another source (i.e., foreign or heterologous to the promoter, the wildtype/mutated TriA nucleic acid sequence of interest, the plant host, or any combination thereof). Convenient termination regions are available from the Ti-plasmid of  A. tumefaciens , such as the octopine synthase and nopaline synthase termination regions. See also Guerineau et al. (1991) Mol. Gen. Genet. 262: 141-144; Proudfoot (1991) Cell 64:671-674; Sanfacon et al. (1991) Genes Dev. 5: 141-149; Mogen et al. (1990) Plant Cell 2: 1261-1272; Munroe et al. (1990) Gene 91: 151-158; Ballas t al. (1989) Nucleic Acids Res. 17:7891-7903; and Joshi et al. (1987) Nucleic Acid Res. 15:9627-9639. Where appropriate, the gene(s) may be optimized for increased expression in the transformed plant. That is, the genes can be synthesized using plant-preferred codons for improved expression. See, for example, Campbell and Gowri (1990) Plant Physiol. 92: 1-11 for a discussion of host-preferred codon usage. Methods are available in the art for synthesizing plant-preferred genes. See, for example, U.S. Pat. Nos. 5,380,831, and 5,436,391, and Murray et al. (1989) Nucleic Acids Res. 17:477-498, herein incorporated by reference. 
     Thus, the present invention provides an expression cassette comprising a mutated TriA nucleic acid nucleic acid molecule according to the present invention and a promoter operable in plant cells. 
     In a preferred embodiment, the promoter is a root-specific or root-enhanced promoter. 
     In a particularly preferred embodiment, the promoter is a a root-specific or root-enhanced promoter from  Glycine max . (e.g. p-Glyma04g34080, see Examples 8 and 9) 
     Even more preferably, the promoter comprises the nuclic acid sequence of SEQ ID NO: 32. 
     While the polynucleotides of the invention may find use as selectable marker genes for plant transformation, the expression cassettes of the invention can include another selectable marker gene for the selection of transformed cells. Selectable marker genes, including those of the present invention, are utilized for the selection of transformed cells or tissues. Marker genes include, but are not limited to, genes encoding antibiotic resistance, such as those encoding neomycin phosphotransferase II (NEO) and hygromycin phosphotransferase (HPT), as well as genes conferring resistance to herbicidal compounds, such as glufosinate ammonium, bromoxynil, imidazolinones, and 2,4-dichlorophenoxyacetate (2,4-D). See generally, Yarranton (1992) Curr. Opin. Biotech. 3:506-511; Christophers on et al (1992) Proc. Natl. Acad. ScL USA 89:6314-6318; Yao et al. (1992) Cell 71:63-72; Reznikoff (1992) Mol Microbiol 6:2419-2422; Barkley et al (1980) in The Operon, pp. 177-220; Hu et al (1987) Cell 48:555-566; Brown et al (1987) Cell 49:603-612; Figge et al (1988) Cell 52:713-722; Deuschle et al (1989) Proc. Natl Acad. AcL USA 86:5400-5404; Fuerst et al (1989) Proc. Natl Acad. ScL USA 86:2549-2553; Deuschle et al (1990) Science 248:480-483; Gossen (1993) Ph.D. Thesis, University of Heidelberg; Reines et al (1993) Proc. Natl Acad. ScL USA 90: 1917-1921; Labow et al (1990) Mol Cell Biol 10:3343-3356; Zambretti et al (1992) Proc. Natl Acad. ScL USA 89:3952-3956; Bairn et al (1991) Proc. Natl Acad. ScL USA 88:5072-5076; Wyborski et al (1991) Nucleic Acids Res. 19:4647-4653; Hillenand-Wissman (1989) Topics Mol Struc. Biol 10: 143-162; Degenkolb et al (1991) Antimicrob. Agents Chemother. 35: 1591-1595; Kleinschnidt et al (1988) Biochemistry 27: 1094-1104; Bonin (1993) Ph.D. Thesis, University of Heidelberg; Gossen et al (1992) Proc. Natl Acad. ScL USA 89:5547-5551; Oliva et al (1992) Antimicrob. Agents Chemother. 36:913-919; Hlavka et al (1985) Handbook of Experimental Pharmacology, Vol. 78 (Springer-Verlag, Berlin); Gill et al (1988) Nature 334:721-724. Such disclosures are herein incorporated by reference. The above list of selectable marker genes is not meant to be limiting. Any selectable marker gene can be used in the present invention. 
     Further, additional sequence modifications are known to enhance gene expression in a cellular host. These include elimination of sequences encoding spurious polyadenylation signals, exon-intron splice site signals, transposon-like repeats, and other such well-characterized sequences that may be deleterious to gene expression. The G-C content of the sequence may be adjusted to levels average for a given cellular host, as calculated by reference to known genes expressed in the host cell. Also, if desired, sequences can be readily modified to avoid predicted hairpin secondary mRNA structures. Nucleotide sequences for enhancing gene expression can also be used in the plant expression vectors. These include, for example, introns of the maize Adh gene Adh1-S intron 1, 2, and 6 (Callis et al. Genes and Development 1: 1183-1200, 1987), and leader sequences, (W-sequence) from the Tobacco Mosaic virus (TMV), Maize Chlorotic Mottle Virus and Alfalfa Mosaic Virus (Gallie et al. Nucleic Acid Res. 15:8693-8711, 1987 and Skuzeski et al. Plant Mol. Biol. 15:65-79, 1990). The first intron from the shrunken-1 locus of maize has been shown to increase expression of genes in chimeric gene constructs. U.S. Pat. Nos. 5,424,412 and 5,593,874 disclose the use of specific introns in gene expression constructs, and Gallie et al. (Plant Physiol. 106:929-939, 1994) also have shown that introns are useful for regulating gene expression on a tissue specific basis. To further enhance or to optimize gene expression, the plant expression vectors of the invention also may contain DNA sequences containing matrix attachment regions (MARs). Plant cells transformed with such modified expression systems, then, may exhibit overexpression or constitutive expression of a nucleotide sequence of the invention. 
     The invention further provides an isolated recombinant expression vector comprising the expression cassette containing a wildtype/mutated TriA nucleic acid nucleic acid as described above, wherein expression of the vector in a host cell results in increased tolerance to a herbicide as compared to a wild type variety of the host cell. As used herein, the term “vector” refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a “plasmid,” which refers to a circular double stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as “expression vectors.” In general, expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. In the present specification, “plasmid” and “vector” can be used interchangeably as the plasmid is the most commonly used form of vector. However, the invention is intended to include such other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses, and adeno-associated viruses), which serve equivalent functions. 
     The recombinant expression vectors of the invention comprise a nucleic acid of the invention in a form suitable for expression of the nucleic acid in a host cell, which means that the recombinant expression vectors include one or more regulatory sequences, selected on the basis of the host cells to be used for expression, which is operably linked to the nucleic acid sequence to be expressed. Regulatory sequences include those that direct constitutive expression of a nucleotide sequence in many types of host cells and those that direct expression of the nucleotide sequence only in certain host cells or under certain conditions. It will be appreciated by those skilled in the art that the design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of polypeptide desired, etc. The expression vectors of the invention can be introduced into host cells to thereby produce polypeptides or peptides, including fusion polypeptides or peptides, encoded by nucleic acids as described herein (e.g., mutated TriA polypeptides, fusion polypeptides, etc.) 
     Expression vectors may additionally contain 5′ leader sequences in the expression construct. Such leader sequences can act to enhance translation. Translation leaders are known in the art and include: picornavirus leaders, for example, EMCV leader (Encephalomyo carditis 5′ noncoding region) (Elroy-Stein et al. (1989) PNAS, 86:6126-6130); potyvirus leaders, for example, TEV leader (Tobacco Etch Virus) (Gallie et al. (1995) Gene 165(2):233-238), MDMV leader (Maize Dwarf Mosaic Virus) (Virology 154:9-20), and human immunoglobulin heavy-chain binding protein (BiP) (Macejak et al. (1991) Nature 353:90-94); untranslated leader from the coat protein mRNA of alfalfa mosaic virus (AMV RNA 4) (Jobling et al. (1987) Nature 325:622-625); tobacco mosaic virus leader (TMV) (Gallie et al. (1989) in Molecular Biology of RNA, ed. Cech (Liss, New York), pp. 237-256); and maize chlorotic mottle virus leader (MCMV) (Lommel et al. (1991) Virology 81:382-385). See also, Della-Cioppa et al. (1987) Plant Physiol. 84:965-968. 
     Other methods known to enhance translation also can be utilized, for example, introns, and the like. In preparing an expression vector, the various nucleic acid fragments may be manipulated, so as to provide for the nucleic acid sequences in the proper orientation and, as appropriate, in the proper reading frame. Toward this end, adapters or linkers may be employed to join the nucleic acid fragments or other manipulations may be involved to provide for convenient restriction sites, removal of superfluous nucleic acid, removal of restriction sites, or the like. For this purpose, in vitro mutagenesis, primer repair, restriction, annealing, resubstitutions, e.g., transitions and transversions, may be involved. 
     A number of promoters can be used in the practice of the invention. The promoters can be selected based on the desired outcome. The nucleic acids can be combined with constitutive, tissue-preferred, or other promoters for expression in plants. 
     Constitutive promoters include, for example, the core promoter of the Rsyn7 promoter and other constitutive promoters disclosed in WO 99/43838 and U.S. Pat. No. 6,072,050; the core CaMV 35S promoter (Odell et al. (1985) Nature 313:810-812); rice actin (McElroy et al. (1990) Plant Cell 2: 163-171); ubiquitin (Christensen et al. (1989) Plant Mol. Biol. 12:619-632 and Christensen et al. (1992) Plant Mol. Biol. 18:675-689); pEMU (Last et al. (1991) Theor. Appl. Genet. 81:581-588); MAS (Velten et al. (1984) EMBO J. 3:2723-2730); ALS promoter (U.S. Pat. No. 5,659,026), and the like. Other constitutive promoters include, for example, U.S. Pat. Nos. 5,608,149; 5,608,144; 5,604,121; 5,569,597; 5,466,785; 5,399,680; 5,268,463; 5,608,142; and 6,177,611. 
     Tissue-preferred promoters can be utilized to target enhanced expression within a particular plant tissue. Such tissue-preferred promoters include, but are not limited to, leaf-preferred promoters, root-preferred promoters, seed-preferred promoters, and stem-preferred promoters. Some examples of tissue-preferred promoters are described by, e.g., Yamamoto et al. (1997) Plant J. 12(2):255-265; Kawamata et al. (1997) Plant Cell Physiol. 38(7):792-803; Hansen et al. (1997) Mol. Gen Genet. 254(3):337-343; Russell et al. (1997) Transgenic Res. 6(2): 157-168; Rinehart et al. (1996) Plant Physiol. 112(3): 1331-1341; Van Camp et al. (1996) Plant Physiol. 112(2):525-535; Canevascini et al. (1996) Plant Physiol. 112(2):513-524; Yamamoto et al. (1994) Plant Cell Physiol. 35(5):773-778; Lam (1994) Results Probl. Cell Differ. 20:181-196; Orozco ef al. (1993) Plant Mol Biol. 23(6): 1129-1138; Matsuoka et al. (1993) Voc Natl. Acad. ScL USA 90(20):9586-9590; and Guevara-Garcia et al. (1993) Plant J 4(3):495-505. Promoters can be modified, if necessary, for weak expression. 
     In a preferred embodiment, the promoter is a root-specific or root-enhanced promoter. 
     In a particularly preferred embodiment, the promoter comprises the nucleic acid sequence of SEQ ID NO: 32. 
     In some embodiments, the nucleic acids of interest can be targeted to the chloroplast for expression. In this manner, where the nucleic acid of interest is not directly inserted into the chloroplast, the expression vector will additionally contain a chloroplast-targeting sequence comprising a nucleotide sequence that encodes a chloroplast transit peptide to direct the gene product of interest to the chloroplasts. Such transit peptides are known in the art. With respect to chloroplast-targeting sequences, “operably linked” means that the nucleic acid sequence encoding a transit peptide (i.e., the chloroplast-targeting sequence) is linked to the desired coding sequence of the invention such that the two sequences are contiguous and in the same reading frame. See, for example, Von Heijne et al. (1991) Plant Mol. Biol. Rep. 9: 104-126; Clark et al. (1989) J Biol. Chem. 264:17544-17550; Della-Cioppa et al. (1987) Plant Physiol. 84:965-968; Romer et al. (1993) Biochem. Biophys. Res. Commun. 196: 1414-1421; and Shah et al. (1986) Science 233:478-481. For example, a chloroplast transit peptide known in the art can be fused to the amino acid sequence of a TriA polypeptide of the invention by operably linking a choloroplast-targeting sequence to the 5′-end of a nucleotide sequence encoding the TriA polypeptide. 
     Chloroplast targeting sequences are known in the art and include the chloroplast small subunit of ribulose-1,5-bisphosphate carboxylase (Rubisco) (de Castro Silva Filho et al. (1996) Plant Mol. Biol. 30:769-780; Schnell et al. (1991) J Biol. Chem. 266(5):3335-3342); EPSPS (Archer et al. (1990) J Bioenerg. Biomemb. 22(6):789-810); tryptophan synthase (Zhao et al. (1995) J Biol. Chem. 270(11):6081-6087); plastocyanin (Lawrence et al. (1997) J Biol. Chem. 272(33):20357-20363); chorismate synthase (Schmidt et al. (1993) J Biol. Chem. 268(36):27447-27457); and the light harvesting chlorophyll a/b binding protein (LHBP) (Lamppa et al. (1988) J Biol. Chem. 263: 14996-14999). See also Von Heijne et al. (1991) Plant Mol. Biol. Rep. 9: 104-126; Clark et al. (1989) J Biol. Chem. 264: 17544-17550; Della-Cioppa et al. (1987) Plant Physiol. 84:965-968; Romer et al. (1993) Biochem Biophys. Res. Commun. 196: 1414-1421; and Shah et al. (1986) Science 233:478-481. 
     Methods for transformation of chloroplasts are known in the art. See, for example, Svab et al. (1990) Proc. Natl. Acad. ScL USA 87:8526-8530; Svab and Maliga (1993) Proc. Natl. Acad. Sci. USA 90:913-917; Svab and Maliga (1993) EMBO J. 12:601-606. The method relies on particle gun delivery of DNA containing a selectable marker and targeting of the DNA to the plastid genome through homologous recombination. Additionally, plastid transformation can be accomplished by transactivation of a silent plastid-borne transgene by tissue-preferred expression of a nuclear-encoded and plastid-directed RNA polymerase. Such a system has been reported in McBride et al. (1994) Proc. Natl. Acad. Sci. USA 91:7301-7305. 
     The nucleic acids of interest to be targeted to the chloroplast may be optimized for expression in the chloroplast to account for differences in codon usage between the plant nucleus and this organelle. In this manner, the nucleic acids of interest may be synthesized using chloroplast-preferred codons. See, for example, U.S. Pat. No. 5,380,831, herein incorporated by reference. 
     Numerous plant transformation vectors and methods for transforming plants are available. See, for example, An, G. et al. (1986) Plant PysioL, 81:301-305; Fry, J., et al. (1987) Plant Cell Rep. 6:321-325; Block, M. (1988) Theor. Appl. Genet 0.16: 161-1 1 A; Hinchee, et al. (1990) Stadler. Genet. Symp. 2032Y2.203-2Y2; Cousins, et al. (1991) Aust. J. Plant Physiol. 18:481-494; Chee, P. P. and Slightom, J. L. (1992) Gene. I I 8:255-260; Christou, et al. (1992) Trends. Biotechnol. 10:239-246; Halluin, et al. (1992) Bio/Technol. 10:309-314; Dhir, et al. (1992) Plant Physiol. 99:81-88; Casas et al. (1993) Proc. Nat. Acad Sd. USA 90: 11212-11216; Christou, P. (1993) In Vitro Cell. Dev. Biol.-Plant; 29P. 119-124; Davies, et al. (1993) Plant Cell Rep. 12: 180-183; Dong, J. A. and Mchughen, A. (1993) Plant ScL 91: 139-148; Franklin, C. I. and Trieu, T. N. (1993) Plant. Physiol. 102: 167; Golovkin, et al. (1993) Plant ScL 90:41-52; Guo Chin ScL Bull. 38:2072-2078; Asano, et al. (1994) Plant Cell Rep. 13; Ayeres N. M. and Park, W. D. (1994) Crit. Rev. Plant. Sci. 13:219-239; Barcelo, et al. (1994) Plant. J. 5:583-592; Becker, et al. (1994) Plant. J. 5:299-307; Borkowska et al. (1994) Acta. Physiol Plant. 16:225-230; Christou, P. (1994) Agro. Food. Ind. Hi Tech. 5: 17-27; Eapen et al. (1994) Plant Cell Rep. 13:582-586; Hartman, et al. (1994) Bio-Technology 12: 919923; Ritala, et al. (1994) Plant. Mol. Biol. 24:317-325; and Wan, Y. C. and Lemaux, P. G. (1994) Plant Physiol. 104:3748. 
     In some embodiments, the methods of the invention involve introducing a polynucleotide construct into a plant. By “introducing” is intended presenting to the plant the polynucleotide construct in such a manner that the construct gains access to the interior of a cell of the plant. The methods of the invention do not depend on a particular method for introducing a polynucleotide construct to a plant, only that the polynucleotide construct gains access to the interior of at least one cell of the plant. Methods for introducing polynucleotide constructs into plants are known in the art including, but not limited to, stable transformation methods, transient transformation methods, and virus-mediated methods. The term “introduction” or “transformation” as referred to herein further means the transfer of an exogenous polynucleotide into a host cell, irrespective of the method used for transfer. Plant tissue capable of subsequent clonal propagation, whether by organogenesis or embryogenesis, may be transformed with a genetic construct of the present invention and a whole plant regenerated there from. The particular tissue chosen will vary depending on the clonal propagation systems available for, and best suited to, the particular species being transformed. Exemplary tissue targets include leaf disks, pollen, embryos, cotyledons, hypocotyls, megagametophytes, callus tissue, existing meristematic tissue (e.g., apical meristem, axillary buds, and root meristems), and induced meristem tissue (e.g., cotyledon meristem and hypocotyl meristem). The polynucleotide may be transiently or stably introduced into a host cell and may be maintained non-integrated, for example, as a plasmid. Alternatively, it may be integrated into the host genome. The resulting transformed plant cell may then be used to regenerate a transformed plant in a manner known to persons skilled in the art. 
     By “stable transformation” is intended that the polynucleotide construct introduced into a plant integrates into the genome of the plant and is capable of being inherited by descendent thereof. By “transient transformation” is intended that a polynucleotide construct introduced into a plant does not integrate into the genome of the plant. 
     For the transformation of plants and plant cells, the nucleotide sequences of the invention are inserted using standard techniques into any vector known in the art that is suitable for expression of the nucleotide sequences in a plant or plant cell. The selection of the vector depends on the preferred transformation technique and the target plant species to be transformed. In an embodiment of the invention, the encoding nucleotide sequence is operably linked to a plant promoter, e.g. a promoter known in the art for high-level expression in a plant cell, and this construct is then introduced into a plant cell that is susceptible to herbicides; and a transformed plant is regenerated. In some embodiments, the transformed plant is tolerant to exposure to a level of herbicides that would kill or significantly injure a plant regenerated from an untransformed cell. This method can be applied to any plant species or crops. 
     Methodologies for constructing plant expression vectors and introducing foreign nucleic acids into plants are generally known in the art. For example, foreign DNA can be introduced into plants, using tumor-inducing (Ti) plasmid vectors. Other methods utilized for foreign DNA delivery involve the use of PEG mediated protoplast transformation, electroporation, microinjection whiskers, and biolistics or microprojectile bombardment for direct DNA uptake. Such methods are known in the art. (U.S. Pat. No. 5,405,765 to Vasil et al.; Bilang et a (1991) Gene 100: 247-250; Scheid et al. al, (1991) MoL Gen. Genet., 228: 104-112; Guerche et al., (1987) Plant Science 52: 111-1 16; Neuhause et al., (1987) Theor. Appl Genet. 75: 30-36; Klein et al., (1987) Nature 327: 70-73; Howell et al., (1980) Science 208: 1265; Horsch et al., (1985) Science 227: 1229-1231; DeBlock et al., (1989) Plant Physiology 91: 694-701; Methods for Plant Molecular Biology (Weissbach and Weissbach, eds.) Academic Press, Inc. (1988) and Methods in Plant Molecular Biology (Schuler and Zielinski, eds.) Academic Press, Inc. (1989). 
     Other suitable methods of introducing nucleotide sequences into plant cells include microinjection as described by, e.g., Crossway et al. (1986) Biotechniques 4:320-334, electroporation as described by e.g., Riggs et al. (1986) Proc. Natl. Acad. ScL USA 83:5602-5606,  Agrobacterium -mediated transformation as described by e.g., Townsend et al., U.S. Pat. No. 5,563,055, Zhao et al., U.S. Pat. No. 5,981,840, direct gene transfer as described by, e.g., Paszkowski et al. (1984) EMBO J. 3:2717-2722, and ballistic particle acceleration as described by, e.g., U.S. Pat. Nos. 4,945,050; 5,879,918; 5,886,244; and U.S. Pat. No. 5,932,782; Tomes et al. (1995) “Direct DNA Transfer into Intact Plant Cells via Microprojectile Bombardment,” in Plant Cell, Tissue, and Organ Culture: Fundamental Methods, ed. Gamborg and Phillips (Springer-Verlag, Berlin); McCabe et al. (1988) Biotechnology 6:923-926); and Led transformation (WO 00/28058). Also see, Weissinger et al., (1988) Ann. Rev. Genet. 22:421-477; Sanford et al, (1987) Particulate Science and Technology 5:27-37 (onion); Christou et al, (1988) Plant Physiol. 87:671-674 (soybean); McCabe et al., (1988) Bio/Technology 6:923-926 (soybean); Finer and McMullen (1991) In Vitro Cell Dev. Biol. 27P: 175-182 (soybean); Singh et al, (1998) Theor. Appl. Genet. 96:319-324 (soybean); Datta et al., (1990) Biotechnology 8:736-740 (rice); Klein et al., (1988) PNAS, 85:4305-4309 (maize); Klein et al., (1988) Biotechnology 6:559-563 (maize); U.S. Pat. Nos. 5,240,855; 5,322,783; and U.S. Pat. No. 5,324,646; Tomes et al., (1995) “Direct DNA Transfer into Intact Plant Cells via Microprojectile Bombardment,” in Plant Cell, Tissue, and Organ Culture: Fundamental Methods, ed. Gamborg (Springer-Verlag, Berlin) (maize); Klein et al., (1988) Plant Physiol. 91:440-444 (maize); Fromm et al., (1990) Biotechnology 8:833-839 (maize); Hooykaas-Van Slogteren et al., (1984) Nature (London) 311:763-764; Bowen et al, U.S. Pat. No. 5,736,369 (cereals); Bytebier et al, (1987) PNAS 84:5345-5349 (Liliaceae); De Wet et al., (1985) in The Experimental Manipulation of Ovule Tissues, ed. Chapman et al, (Longman, N.Y.), pp. 197-209 (pollen); Kaeppler et al., (1990) Plant Cell Reports 9:415-418 and Kaeppler et al., (1992) Theor. Apph Genet. 84:560-566 (whisker-mediated transformation); D&#39;Halluin et al., (1992) Plant Cell 4: 1495-1505 (electroporation); Li et al., (1993) Plant Cell Reports 12:250-255 and Christou and Ford (1995) Annals of Botany 75:407-413 (rice); Osjoda et al, (1996) Nature Biotechnology 14:745-750 (maize via  Agrobacterium tumefaciens ); each of which is herein incorporated by reference. 
     Transgenic plants, including transgenic crop plants, are preferably produced via  Agrobacterium -mediated transformation. An advantageous transformation method is the transformation in planta. To this end, it is possible, for example, to allow the agrobacteria to act on plant seeds or to inoculate the plant meristem with agrobacteria. It has proved particularly expedient in accordance with the invention to allow a suspension of transformed agrobacteria to act on the intact plant or at least on the flower primordia. The plant is subsequently grown on until the seeds of the treated plant are obtained (Clough and Bent, Plant J. (1998) 16, 735-743). Methods for  Agrobacterium -mediated transformation of rice include well known methods for rice transformation, such as those described in any of the following: European patent application EP 1198985 A1, Aldemita and Hodges (Planta 199: 612-617, 1996); Chan et al. (Plant Mol Biol 22 (3): 491-506, 1993), Hiei et al. (Plant J 6 (2): 271-282, 1994), which disclosures are incorporated by reference herein as if fully set forth. In the case of corn transformation, the preferred method is as described in either Ishida et al. (Nat. Biotechnol 14(6): 745-50, 1996) or Frame et al. (Plant Physiol 129(1): 13-22, 2002), which disclosures are incorporated by reference herein as if fully set forth. Said methods are further described by way of example in B. Jenes et al., Techniques for Gene Transfer, in: Transgenic Plants, Vol. 1, Engineering and Utilization, eds. S. D. Kung and R. Wu, Academic Press (1993) 128-143 and in Potrykus Annu. Rev. Plant Physiol. Plant Molec. Biol. 42 (1991) 205-225). The nucleic acids or the construct to be expressed is preferably cloned into a vector, which is suitable for transforming  Agrobacterium tumefaciens , for example pBin19 (Bevan et al., Nucl. Acids Res. 12 (1984) 8711). Agrobacteria transformed by such a vector can then be used in known manner for the transformation of plants, such as plants used as a model, like  Arabidopsis  ( Arabidopsis thaliana  is within the scope of the present invention not considered as a crop plant), or crop plants such as, by way of example, tobacco plants, for example by immersing bruised leaves or chopped leaves in an agrobacterial solution and then culturing them in suitable media. The transformation of plants by means of  Agrobacterium tumefaciens  is described, for example, by Höfgen and Willmitzer in Nucl. Acid Res. (1988) 16, 9877 or is known inter alia from F. F. White, Vectors for Gene Transfer in Higher Plants; in Transgenic Plants, Vol. 1, Engineering and Utilization, eds. S. D. Kung and R. Wu, Academic Press, 1993, pp. 15-38. 
     One transformation method known to those of skill in the art is the dipping of a flowering plant into an Agrobacteria solution, wherein the Agrobacteria contains the TriA nucleic acid, followed by breeding of the transformed gametes.  Agrobacterium  mediated plant transformation can be performed using for example the GV3101 (pMP90) (Koncz and Schell, 1986, Mol. Gen. Genet. 204:383-396) or LBA4404 (Clontech)  Agrobacterium tumefaciens  strain. Transformation can be performed by standard transformation and regeneration techniques (Deblaere et al., 1994, Nucl. Acids. Res. 13:4777-4788; Gelvin, Stanton B. and Schilperoort, Robert A, Plant Molecular Biology Manual, 2nd Ed.—Dordrecht: Kluwer Academic Publ., 1995.—in Sect., Ringbuc Zentrale Signatur: BT11-P ISBN 0-7923-2731-4; Glick, Bernard R. and Thompson, John E., Methods in Plant Molecular Biology and Biotechnology, Boca Raton: CRC Press, 1993 360 S., ISBN 0-8493-5164-2). For example, rapeseed can be transformed via cotyledon or hypocotyl transformation (Moloney et al., 1989, Plant Cell Report 8:238-242; De Block et al., 1989, Plant Physiol. 91:694-701). Use of antibiotics for  Agrobacterium  and plant selection depends on the binary vector and the  Agrobacterium  strain used for transformation. Rapeseed selection is normally performed using kanamycin as selectable plant marker.  Agrobacterium  mediated gene transfer to flax can be performed using, for example, a technique described by Mlynarova et al., 1994, Plant Cell Report 13:282-285. Additionally, transformation of soybean can be performed using for example a technique described in European Patent No. 0424 047, U.S. Pat. No. 5,322,783, European Patent No. 0397 687, U.S. Pat. No. 5,376,543, or U.S. Pat. No. 5,169,770. Transformation of maize can be achieved by particle bombardment, polyethylene glycol mediated DNA uptake, or via the silicon carbide fiber technique. (See, for example, Freeling and Walbot “The maize handbook” Springer Verlag: New York (1993) ISBN 3-540-97826-7). A specific example of maize transformation is found in U.S. Pat. No. 5,990,387, and a specific example of wheat transformation can be found in PCT Application No. WO 93/07256. 
     In some embodiments, polynucleotides of the present invention may be introduced into plants by contacting plants with a virus or viral nucleic acids. Generally, such methods involve incorporating a polynucleotide construct of the invention within a viral DNA or RNA molecule. It is recognized that the polypeptides of the invention may be initially synthesized as part of a viral polyprotein, which later may be processed by proteolysis in vivo or in vitro to produce the desired recombinant polypeptide. Further, it is recognized that promoters of the invention also encompass promoters utilized for transcription by viral RNA polymerases. Methods for introducing polynucleotide constructs into plants and expressing a protein encoded therein, involving viral DNA or RNA molecules, are known in the art. See, for example, U.S. Pat. Nos. 5,889,191, 5,889,190, 5,866,785, 5,589,367 and 5,316,931; herein incorporated by reference. The cells that have been transformed may be grown into plants in accordance with conventional ways. See, for example, McCormick et a (1986) Plant Cell Reports 5:81-84. These plants may then be grown, and either pollinated with the same transformed strain or different strains, and the resulting hybrid having constitutive expression of the desired phenotypic characteristic identified. Two or more generations may be grown to ensure that expression of the desired phenotypic characteristic is stably maintained and inherited and then seeds harvested to ensure expression of the desired phenotypic characteristic has been achieved. 
     The present invention may be used for transformation of any plant species, including, but not limited to, monocots and dicots. Examples of plant species of interest include, but are not limited to, corn or maize ( Zea mays ),  Brassica  sp. (e.g.,  B. napus, B. rapa, B. juncea ), particularly those  Brassica  species useful as sources of seed oil, alfalfa ( Medicago sativa ), rice ( Oryza sativa ), rye ( Secale cereale ), sorghum ( Sorghum bicolor, Sorghum vulgare ), millet e.g., pearl millet ( Pennisetum glaucum ), proso millet ( Panicum miliaceum ), foxtail millet ( Setaria italica ), finger millet ( Eleusine coracana )), sunflower ( Helianthus annu ), saffiower ( Carthamus tinctorius ), wheat ( Triticum aestivum , T.  Turgidum  ssp. durum), soybean ( Glycine max ), tobacco ( Nicotiana tabacum ), potato (Solarium  tuberosum ), peanuts ( Arachis hypogaea ), cotton ( Gossypium barbadense, Gossypium hirsutum ), sweet potato ( Ipomoea batatus ), cassava ( Manihot esculenta ), coffee ( Coffea  spp.), coconut ( Cocos nucifera ), pineapple ( Ananas comosus ), citrus trees ( Citrus  spp.), cocoa ( Theobroma cacao ), tea ( Camellia sinensis ), banana ( Musa  spp.), avocado ( Persea americana ), fig ( Ficus  casica), guava ( Psidium guajava ), mango ( Mangifera indica ), olive ( Olea europaea ),  papaya  ( Carica papaya ), cashew ( Anacardium occidentale ), macadamia (Macadamia  integrifolia ), almond ( Prunus  amygdalus), sugar beets ( Beta vulgaris ), sugarcane ( Saccharum  spp.), oats, barley, vegetables, ornamentals, and conifers. Preferably, plants of the present invention are crop plants (for example, sunflower,  Brassica  sp., cotton, sugar, beet, soybean, peanut, alfalfa, safflower, tobacco, corn, rice, wheat, rye, barley triticale, sorghum, millet, etc.). 
     In addition to the transformation of somatic cells, which then have to be regenerated into intact plants, it is also possible to transform the cells of plant meristems and in particular those cells which develop into gametes. In this case, the transformed gametes follow the natural plant development, giving rise to transgenic plants. Thus, for example, seeds of  Arabidopsis  are treated with agrobacteria and seeds are obtained from the developing plants of which a certain proportion is transformed and thus transgenic [Feldman, K A and Marks M D (1987). Mol Gen Genet 208:274-289; Feldmann K (1992). In: C Koncz, N-H Chua and J Shell, eds, Methods in  Arabidopsis  Research. Word Scientific, Singapore, pp. 274-289]. Alternative methods are based on the repeated removal of the inflorescences and incubation of the excision site in the center of the rosette with transformed agrobacteria, whereby transformed seeds can likewise be obtained at a later point in time (Chang (1994). Plant J. 5: 551-558; Katavic (1994). Mol Gen Genet, 245: 363-370). However, an especially effective method is the vacuum infiltration method with its modifications such as the “floral dip” method. In the case of vacuum infiltration of  Arabidopsis , intact plants under reduced pressure are treated with an agrobacterial suspension [Bechthold, N (1993). C R Acad Sci Paris Life Sci, 316: 1194-1199], while in the case of the “floral dip” method the developing floral tissue is incubated briefly with a surfactant-treated agrobacterial suspension [Clough, S J and Bent AF (1998) The Plant J. 16, 735-743]. A certain proportion of transgenic seeds are harvested in both cases, and these seeds can be distinguished from non-transgenic seeds by growing under the above-described selective conditions. In addition the stable transformation of plastids is of advantages because plastids are inherited maternally is most crops reducing or eliminating the risk of transgene flow through pollen. The transformation of the chloroplast genome is generally achieved by a process which has been schematically displayed in Klaus et al., 2004 [Nature Biotechnology 22 (2), 225-229]. Briefly the sequences to be transformed are cloned together with a selectable marker gene between flanking sequences homologous to the chloroplast genome. These homologous flanking sequences direct site specific integration into the plastome. Plastidal transformation has been described for many different plant species and an overview is given in Bock (2001) Transgenic plastids in basic research and plant biotechnology. J Mol Biol. 2001 Sep. 21; 312 (3):425-38 or Maliga, P (2003) Progress towards commercialization of plastid transformation technology. Trends Biotechnol. 21, 20-28. Further biotechnological progress has recently been reported in form of marker free plastid transformants, which can be produced by a transient co-integrated maker gene (Klaus et al., 2004, Nature Biotechnology 22(2), 225-229). The genetically modified plant cells can be regenerated via all methods with which the skilled worker is familiar. Suitable methods can be found in the abovementioned publications by S. D. Kung and R. Wu, Potrykus or Höfgen and Willmitzer. 
     Generally after transformation, plant cells or cell groupings are selected for the presence of one or more markers which are encoded by plant-expressible genes co-transferred with the gene of interest, following which the transformed material is regenerated into a whole plant. To select transformed plants, the plant material obtained in the transformation is, as a rule, subjected to selective conditions so that transformed plants can be distinguished from untransformed plants. For example, the seeds obtained in the above-described manner can be planted and, after an initial growing period, subjected to a suitable selection by spraying. A further possibility consists in growing the seeds, if appropriate after sterilization, on agar plates using a suitable selection agent so that only the transformed seeds can grow into plants. Alternatively, the transformed plants are screened for the presence of a selectable marker such as the ones described above. 
     Following DNA transfer and regeneration, putatively transformed plants may also be evaluated, for instance using Southern analysis, for the presence of the gene of interest, copy number and/or genomic organisation. Alternatively or additionally, expression levels of the newly introduced DNA may be monitored using Northern and/or Western analysis, both techniques being well known to persons having ordinary skill in the art. 
     The generated transformed plants may be propagated by a variety of means, such as by clonal propagation or classical breeding techniques. For example, a first generation (or T1) transformed plant may be selfed and homozygous second-generation (or T2) transformants selected, and the T2 plants may then further be propagated through classical breeding techniques. The generated transformed organisms may take a variety of forms. For example, they may be chimeras of transformed cells and non-transformed cells; clonal transformants (e.g., all cells transformed to contain the expression cassette); grafts of transformed and untransformed tissues (e.g., in plants, a transformed rootstock grafted to an untransformed scion). 
     Preferably, the expression of the nucleic acid in the plant results in the plant&#39;s increased resistance to herbicide as compared to a wild type variety of the plant. 
     In another embodiment, the invention refers to a plant, comprising a plant cell according to the present invention, wherein expression of the nucleic acid in the plant results in the plant&#39;s increased resistance to herbicide as compared to a wild type variety of the plant. 
     The plants described herein can be either transgenic crop plants or non-transgenic plants. 
     In addition to the general definition, give SUPRA, “transgenic”, “transgene” or “recombinant” means with regard to, for example, a nucleic acid sequence, an expression cassette, gene construct or a vector comprising the nucleic acid sequence or an organism transformed with the nucleic acid sequences, expression cassettes or vectors according to the invention, all those constructions brought about by recombinant methods in which either
     (a) the nucleic acid sequences encoding proteins useful in the methods of the invention, or   (b) genetic control sequence(s) which is operably linked with the nucleic acid sequence according to the invention, for example a promoter, or   (c) a) and b)   

     are not located in their natural genetic environment or have been modified by recombinant methods, it being possible for the modification to take the form of, for example, a substitution, addition, deletion, inversion or insertion of one or more nucleotide residues in order to allow for the expression of the mutated TriA of the present invention. The natural genetic environment is understood as meaning the natural genomic or chromosomal locus in the original plant or the presence in a genomic library. In the case of a genomic library, the natural genetic environment of the nucleic acid sequence is preferably retained, at least in part. The environment flanks the nucleic acid sequence at least on one side and has a sequence length of at least 50 bp, preferably at least 500 bp, especially preferably at least 1000 bp, most preferably at least 5000 bp. A naturally occurring expression cassette—for example the naturally occurring combination of the natural promoter of the nucleic acid sequences with the corresponding nucleic acid sequence encoding a polypeptide useful in the methods of the present invention, as defined above—becomes a transgenic expression cassette when this expression cassette is modified by non-natural, synthetic (“artificial”) methods such as, for example, mutagenic treatment. Suitable methods are described, for example, in U.S. Pat. No. 5,565,350 or WO 00/15815. 
     A transgenic plant for the purposes of the invention is thus understood as meaning, as above, that the nucleic acids of the invention are not at their natural locus in the genome of said plant, it being possible for the nucleic acids to be expressed homologously or heterologously. However, as mentioned, transgenic also means that, while the nucleic acids according to the invention or used in the inventive method are at their natural position in the genome of a plant, the sequence has been modified with regard to the natural sequence, and/or that the regulatory sequences of the natural sequences have been modified. Transgenic is preferably understood as meaning the expression of the nucleic acids according to the invention at an unnatural locus in the genome, i.e. homologous or, preferably, heterologous expression of the nucleic acids takes place. Preferred transgenic plants are mentioned herein. Furthermore, the term “transgenic” refers to any plant, plant cell, callus, plant tissue, or plant part, that contains all or part of at least one recombinant polynucleotide. In many cases, all or part of the recombinant polynucleotide is stably integrated into a chromosome or stable extra-chromosomal element, so that it is passed on to successive generations. For the purposes of the invention, the term “recombinant polynucleotide” refers to a polynucleotide that has been altered, rearranged, or modified by genetic engineering. Examples include any cloned polynucleotide, or polynucleotides, that are linked or joined to heterologous sequences. The term “recombinant” does not refer to alterations of polynucleotides that result from naturally occurring events, such as spontaneous mutations, or from non-spontaneous mutagenesis followed by selective breeding. 
     “Alleles” or “allelic variants” are alternative forms of a given gene, located at the same chromosomal position. Allelic variants encompass Single Nucleotide Polymorphisms (SNPs), as well as Small Insertion/Deletion Polymorphisms (INDELs). The size of INDELs is usually less than 100 bp. SNPs and INDELs form the largest set of sequence variants in naturally occurring polymorphic strains of most organisms 
     The term “variety” refers to a group of plants within a species defined by the sharing of a common set of characteristics or traits accepted by those skilled in the art as sufficient to distinguish one cultivar or variety from another cultivar or variety. There is no implication in either term that all plants of any given cultivar or variety will be genetically identical at either the whole gene or molecular level or that any given plant will be homozygous at all loci. A cultivar or variety is considered “true breeding” for a particular trait if, when the true-breeding cultivar or variety is self-pollinated, all of the progeny contain the trait. The terms “breeding line” or “line” refer to a group of plants within a cultivar defined by the sharing of a common set of characteristics or traits accepted by those skilled in the art as sufficient to distinguish one breeding line or line from another breeding line or line. There is no implication in either term that all plants of any given breeding line or line will be genetically identical at either the whole gene or molecular level or that any given plant will be homozygous at all loci. A breeding line or line is considered “true breeding” for a particular trait if, when the true-breeding line or breeding line is self-pollinated, all of the progeny contain the trait. In the present invention, the trait arises from a mutation in a TriA gene of the plant or seed. 
     The herbicide-resistant plants of the invention that comprise polynucleotides encoding mutated TriA polypeptides also find use in methods for increasing the herbicide-resistance of a plant through conventional plant breeding involving sexual reproduction. The methods comprise crossing a first plant that is a herbicide-resistant plant of the invention to a second plant that may or may not be resistant to the same herbicide or herbicides as the first plant or may be resistant to different herbicide or herbicides than the first plant. The second plant can be any plant that is capable of producing viable progeny plants (i.e., seeds) when crossed with the first plant. Typically, but not necessarily, the first and second plants are of the same species. The methods can optionally involve selecting for progeny plants that comprise the mutated TriA polypeptides of the first plant and the herbicide resistance characteristics of the second plant. The progeny plants produced by this method of the present invention have increased resistance to a herbicide when compared to either the first or second plant or both. When the first and second plants are resistant to different herbicides, the progeny plants will have the combined herbicide tolerance characteristics of the first and second plants. The methods of the invention can further involve one or more generations of backcrossing the progeny plants of the first cross to a plant of the same line or genotype as either the first or second plant. Alternatively, the progeny of the first cross or any subsequent cross can be crossed to a third plant that is of a different line or genotype than either the first or second plant. 
     The present invention also provides plants, plant organs, plant tissues, plant cells, seeds, and non-human host cells that are transformed with the at least one polynucleotide molecule, expression cassette, or transformation vector of the invention. Such transformed plants, plant organs, plant tissues, plant cells, seeds, and non-human host cells have enhanced tolerance or resistance to at least one herbicide, at levels of the herbicide that kill or inhibit the growth of an untransformed plant, plant tissue, plant cell, or non-human host cell, respectively. Preferably, the transformed plants, plant tissues, plant cells, and seeds of the invention are  Arabidopsis thaliana  and crop plants. 
     In another embodiment, the invention refers to a seed produced by a transgenic plant comprising a plant cell of the present invention, wherein the seed is true breeding for an increased resistance to a herbicide as compared to a wild type variety of the seed. 
     In other aspects, herbicide-tolerant plants of the present invention can be employed as herbicide-tolerance trait donor lines for development, as by traditional plant breeding, to produce other varietal and/or hybrid crops containing such trait or traits. All such resulting variety or hybrids crops, containing the ancestral herbicide-tolerance trait or traits can be referred to herein as progeny or descendant of the ancestral, herbicide-tolerant line(s). 
     In other embodiments, the present invention provides a method for producing a herbicide-tolerant plant. The method comprises: crossing a first herbicide-tolerant plant with a second plant to produce a herbicide-tolerant progeny plant, wherein the first plant and the progeny plant comprise in at least some of their cells a polynucleotide operably linked to a promoter operable in plant cells, the recombinant polynucleotide being effective in the cells of the first plant to express a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to herbicides. 
     Traditional plant breeding might be employed whereby the herbicide-tolerant trait is introduced in the progeny plant resulting therefrom. In one embodiment, the present invention provides a method for producing a herbicide-tolerant progeny plant, the method comprising: crossing a parent plant with a herbicide-tolerant plant to introduce the herbicide-tolerance characteristics of the herbicide-tolerant plant into the germplasm of the progeny plant, wherein the progeny plant has increased tolerance to the herbicides relative to the parent plant. In other embodiments, the method further comprises the step of introgressing the herbicide-tolerance characteristics through traditional plant breeding techniques to obtain a descendent plant having the herbicide-tolerance characteristics. 
     In other aspects, plants of the invention include those plants which, in addition to being tolerant to herbicides inhibiting cellulose biosynthesis, have been subjected to further genetic modifications by breeding, mutagenesis or genetic engineering, e.g. have been rendered tolerant to applications of specific other classes of herbicides, such as AHAS inhibitors; auxinic herbicides; bleaching herbicides such as hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors or phytoene desaturase (PDS) inhibitors; EPSPS inhibitors such as glyphosate; glutamine synthetase (GS) inhibitors such as glufosinate; lipid biosynthesis inhibitors such as acetyl CoA carboxylase (ACCase) inhibitors; or oxynil {i.e. bromoxynil or ioxynil) herbicides as a result of conventional methods of breeding or genetic engineering, Thus, herbicide-tolerant plants of the invention can be made resistant to multiple classes of herbicides through multiple genetic modifications, such as resistance to both glyphosate and glufosinate or to both glyphosate and a herbicide from another class such as HPPD inhibitors, AHAS inhibitors, or ACCase inhibitors. These herbicide resistance technologies are, for example, described in Pest Management Science (at volume, year, page): 61, 2005, 246; 61, 2005, 258; 61, 2005, 277; 61, 2005, 269; 61, 2005, 286; 64, 2008, 326; 64, 2008, 332; Weed Science 57, 2009, 108; Australian Journal of Agricultural Research 58, 2007, 708; Science 316, 2007, 1185; and references quoted therein. For example, herbicide-tolerant plants of the invention, in some embodiments, may be tolerant to ACCase inhibitors, such as “dims” {e.g., cycloxydim, sethoxydim, clethodim, or tepraloxydim), “fops” {e.g., clodinafop, diclofop, fluazifop, haloxyfop, or quizalofop), and “dens” (such as pinoxaden); to auxinic herbicides, such as dicamba; to EPSPS inhibitors, such as glyphosate; to other cellulose biosynthesis inhibitors; and to GS inhibitors, such as glufosinate. 
     In addition to these classes of inhibitors, herbicide-tolerant plants of the invention may also be tolerant to herbicides having other modes of action, for example, chlorophyll/carotenoid pigment inhibitors, cell membrane disrupters, photosynthesis inhibitors, cell division inhibitors, root inhibitors, shoot inhibitors, and combinations thereof. 
     Such tolerance traits may be expressed, e.g.: as mutant or wildtype HPPD proteins, as mutant or wildtype PPO proteins, as mutant AHASL proteins, mutant ACCase proteins, mutant EPSPS proteins, or mutant glutamine synthetase proteins; or as mutant native, inbred, or transgenic aryloxyalkanoate dioxygenase (AAD or DHT), haloarylnitrilase (BXN), 2,2-dichloropropionic acid dehalogenase (DEH), glyphosate-N-acetyltransferase (GAT), glyphosate decarboxylase (GDC), glyphosate oxidoreductase (GOX), glutathione-S-transferase (GST), phosphinothricin acetyltransferase (PAT or bar), or CYP450s proteins having an herbicide-degrading activity. Herbicide-tolerant plants hereof can also be stacked with other traits including, but not limited to, pesticidal traits such as Bt Cry and other proteins having pesticidal activity toward coleopteran, lepidopteran, nematode, or other pests; nutrition or nutraceutical traits such as modified oil content or oil profile traits, high protein or high amino acid concentration traits, and other trait types known in the art. 
     Furthermore, in other embodiments, herbicide-tolerant plants are also covered which are, by the use of recombinant DNA techniques and/or by breeding and/or otherwise selected for such characteristics, rendered able to synthesize one or more insecticidal proteins, especially those known from the bacterial genus  Bacillus , particularly from  Bacillus thuringiensis , such as [delta]-endotoxins, e.g. CrylA(b), CrylA(c), CrylF, CrylF(a2), CryllA(b), CryllIA, CrylllB(b1) or Cry9c; vegetative insecticidal proteins (VIP), e.g. VIP1, VIP2, VIP3 or VIP3A; insecticidal proteins of bacteria colonizing nematodes, e.g.  Photorhabdus  spp. or Xenorhabdus spp.; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins, or other insect-specific neurotoxins; toxins produced by fungi, such streptomycete toxins; plant lectins, such as pea or barley lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin or papain inhibitors; ribosome-inactivating proteins (RIP), such as ricin, maize-RIP, abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such as 3-hydroxy-steroid oxidase, ecdysteroid-IDP-glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors or HMG-CoA-reductase; ion channel blockers, such as blockers of sodium or calcium channels; juvenile hormone esterase; diuretic hormone receptors (helicokinin receptors); stilben synthase, bibenzyl synthase, chitinases or glucanases. In the context of the present invention these insecticidal proteins or toxins are to be understood expressly also as pre-toxins, hybrid proteins, truncated or otherwise modified proteins. Hybrid proteins are characterized by a new combination of protein domains, (see, e.g. WO 02/015701). Further examples of such toxins or genetically modified plants capable of synthesizing such toxins are disclosed, e.g., in EP-A 374 753, WO 93/007278, WO 95/34656, EP-A 427 529, EP-A 451 878, WO 03/18810 und WO 03/52073. The methods for producing such genetically modified plants are generally known to the person skilled in the art and are described, e.g. in the publications mentioned above. These insecticidal proteins contained in the genetically modified plants impart to the plants producing these proteins tolerance to harmful pests from all taxonomic groups of arthropods, especially to beetles (Coeloptera), two-winged insects (Diptera), and moths (Lepidoptera) and to nematodes (Nematoda). 
     In some embodiments, expression of one or more protein toxins (e.g., insecticidal proteins) in the herbicide-tolerant plants is effective for controlling organisms that include, for example, members of the classes and orders: Coleoptera such as the American bean weevil  Acanthoscelides obtectus ; the leaf beetle  Agelastica alni ; click beetles ( Agriotes lineatus, Agriotes obscurus, Agriotes  bicolor); the grain beetle  Ahasverus advena ; the summer schafer  Amphimallon solstitialis ; the furniture beetle  Anobium punctatum; Anthonomus  spp. (weevils); the Pygmy mangold beetle  Atomaria linearis ; carpet beetles ( Anthrenus  spp.,  Attagenus  spp.); the cowpea weevil  Callosobruchus maculates ; the fried fruit beetle  Carpophilus hemipterus ; the cabbage seedpod weevil  Ceutorhynchus assimilis ; the rape winter stem weevil  Ceutorhynchus picitarsis ; the wireworms  Conoderus vespertinus  and  Conoderus falli ; the banana weevil  Cosmopolites sordidus ; the New Zealand grass grub  Costelytra zealandica ; the June beetle  Cotinis nitida ; the sunflower stem weevil 
       Cylindrocopturus adspersus ; the larder beetle  Dermestes lardarius ; the corn rootworms  Diabrotica virgifera, Diabrotica virgifera virgifera , and  Diabrotica barberi ; the Mexican bean beetle  Epilachna varivestis ; the old house borer  Hylotropes bajulus ; the lucerne weevil  Hypera postica ; the shiny spider beetle  Gibbium psylloides ; the cigarette beetle  Lasioderma serricorne ; the Colorado potato beetle  Leptinotarsa decemlineata; Lyctus  beetles { Lyctus  spp., the pollen beetle  Meligethes aeneus ; the common cockshafer  Melolontha melolontha ; the American spider beetle  Mezium americanum ; the golden spider beetle  Niptus hololeuc s ; the grain beetles  Oryzaephilus surinamensis  and  Oryzaephilus mercator ; the black vine weevil  Otiorhynchus sulcatus ; the mustard beetle  Phaedon cochleariae , the crucifer flea beetle  Phyllotreta cruciferae ; the striped flea beetle  Phyllotreta striolata ; the cabbage steam flea beetle  Psylliodes chrysocephala; Ptinus  spp. (spider beetles); the lesser grain borer  Rhizopertha dominica ; the pea and been weevil  Sitona lineatus ; the rice and granary beetles  Sitophilus oryzae  and  Sitophilus granaries ; the red sunflower seed weevil  Smicronyx fulvus ; the drugstore beetle  Stegobium paniceum ; the yellow mealworm beetle  Tenebrio molitor , the flour beetles  Tribolium castaneum  and  Tribolium confusum ; warehouse and cabinet beetles { Trogoderma  spp.); the sunflower beetle  Zygogramma exclamationis ; Dermaptera (earwigs) such as the European earwig  Forficula auricularia  and the striped earwig  Labidura riparia; Dictyoptera  such as the oriental cockroach  Blatta orientalis ; the greenhouse millipede  Oxidus gracilis ; the beet fly  Pegomyia betae ; the frit fly  Oscinella frit ; fruitflies ( Dacus  spp.,  Drosophila  spp.); Isoptera (termites) including species from the familes Hodotermitidae, Kalotermitidae, Mastotermitidae, Rhinotermitidae, Serritermitidae, Termitidae, Termopsidae; the tarnished plant bug  Lygus lineolaris ; the black bean aphid  Aphis fabae ; the cotton or melon aphid  Aphis gossypii ; the green apple aphid  Aphis pomi ; the citrus spiny whitefly  Aleurocanthus spiniferus ; the sweet potato whitefly  Bemesia tabaci ; the cabbage aphid  Brevicoryne brassicae ; the pear  psylla Cacopsylla pyricola ; the currant aphid  Cryptomyzus ribis ; the grape  phylloxera Daktulosphaira vitifoliae ; the citrus  psylla Diaphorina citri ; the potato leafhopper  Empoasca fabae ; the bean leafhopper  Empoasca  Solana; the vine leafhopper  Empoasca vitis ; the woolly aphid  Eriosoma lanigerum ; the European fruit scale  Eulecanium corni ; the mealy plum aphid  Hyalopterus arundinis ; the small brown planthopper  Laodelphax striatellus ; the potato aphid  Macrosiphum euphorbiae ; the green peach aphid  Myzus persicae ; the green rice leafhopper  Nephotettix cinticeps ; the brown planthopper  Nilaparvata lugens ; the hop aphid  Phorodon humuli ; the bird-cherry aphid  Rhopalosiphum padi ; the grain aphid  Sitobion avenae ; Lepidoptera such as  Adoxophyes orana  (summer fruit  tortrix  moth);  Archips podana  (fruit tree  tortrix  moth);  Bucculatrix pyrivorella  (pear leafminer);  Bucculatrix thurberiella  (cotton leaf perforator);  Bupalus piniarius  (pine looper);  Carpocapsa pomonella  (codling moth);  Chilo suppressalis  (striped rice borer);  Choristoneura fumiferana  (eastern spruce budworm);  Cochylis hospes  (banded sunflower moth);  Diatraea grandiosella  (southwestern corn borer);  Eupoecilia ambiguella  (European grape berry moth);  Helicoverpa armigera  (cotton bollworm);  Helicoverpa zea  (cotton bollworm);  Heliothis  vires cens (tobacco budworm),  Homeosoma electellum  (sunflower moth);  Homona magnanima  (oriental tea tree  tortrix  moth);  Lithocolletis blancardella  (spotted tentiform leafminer);  Lymantria dispar  (gypsy moth);  Malacosoma neustria  (tent caterpillar);  Mamestra brassicae  (cabbage armyworm);  Mamestra configurata  (Bertha armyworm);  Operophtera brumata  (winter moth);  Ostrinia nubilalis  (European corn borer),  Panolis flammea  (pine beauty moth),  Phyllocnistis citrella  (citrus leafminer);  Pieris brassicae  (cabbage white butterfly);  Rachiplusia ni  (soybean looper);  Spodoptera exigua  (beet armywonn);  Spodoptera littoralis  (cotton leafworm);  Sylepta derogata  (cotton leaf roller);  Trichoplusia ni  (cabbage looper); Orthoptera such as the common cricket  Acheta domesticus , tree locusts ( Anacridium  spp.), the migratory locust  Locusta migratoria , the twostriped grasshopper  Melanoplus bivittatus , the differential grasshopper  Melanoplus  differ entialis, the redlegged grasshopper  Melanoplus femurrubrum , the migratory grasshopper  Melanoplus sanguinipes , the northern mole cricket  Neocurtilla hexadectyla , the red locust  Nomadacris septemfasciata , the shortwinged mole cricket  Scapteriscus abbreviatus , the southern mole cricket  Scapteriscus borellii , the tawny mole cricket  Scapteriscus vicinus , and the desert locust  Schistocerca gregaria; Symphyla  such as the garden symphylan  Scutigerella immaculata ; Thysanoptera such as the tobacco  thrips Frankliniella fusca , the flower  thrips Frankliniella intonsa , the western flower  thrips Frankliniella occidentalism  the cotton bud  thrips Frankliniella schultzei , the banded greenhouse  thrips Hercinothrips femoralis , the soybean  thrips Neohydatothrips variabilis , Kelly&#39;s citrus  thrips Pezothrips kellyanus , the avocado  thrips Scirtothrips perseae , the melon  thrips Thrips palmi , and the onion  thrips Thrips tabaci ; and the like, and combinations comprising one or more of the foregoing organisms. 
     In some embodiments, expression of one or more protein toxins (e.g., insecticidal proteins) in the herbicide-tolerant plants is effective for controlling flea beetles, i.e. members of the flea beetle tribe of family Chrysomelidae, preferably against  Phyllotreta  spp., such as  Phyllotreta cruciferae  and/or  Phyllotreta triolata . In other embodiments, expression of one or more protein toxins {e.g., insecticidal proteins) in the herbicide-tolerant plants is effective for controlling cabbage seedpod weevil, the Bertha armyworm,  Lygus  bugs, or the diamondback moth. 
     Furthermore, in one embodiment, herbicide-tolerant plants are also covered which are, e.g. by the use of recombinant DNA techniques and/or by breeding and/or otherwise selected for such traits, rendered able to synthesize one or more proteins to increase the resistance or tolerance of those plants to bacterial, viral or fungal pathogens. The methods for producing such genetically modified plants are generally known to the person skilled in the art. 
     Furthermore, in another embodiment, herbicide-tolerant plants are also covered which are, e.g. by the use of recombinant DNA techniques and/or by breeding and/or otherwise selected for such traits, rendered able to synthesize one or more proteins to increase the productivity (e.g. oil content), tolerance to drought, salinity or other growth-limiting environmental factors or tolerance to pests and fungal, bacterial or viral pathogens of those plants. 
     Furthermore, in other embodiments, herbicide-tolerant plants are also covered which are, e.g. by the use of recombinant DNA techniques and/or by breeding and/or otherwise selected for such traits, altered to contain a modified amount of one or more substances or new substances, for example, to improve human or animal nutrition, e.g. oil crops that produce health-promoting long-chain omega-3 fatty acids or unsaturated omega-9 fatty acids (e.g. Nexera® rape, Dow Agro Sciences, Canada). 
     Furthermore, in some embodiments, herbicide-tolerant plants are also covered which are, e.g. by the use of recombinant DNA techniques and/or by breeding and/or otherwise selected for such traits, altered to contain increased amounts of vitamins and/or minerals, and/or improved profiles of nutraceutical compounds. 
     In one embodiment, herbicide-tolerant plants of the present invention, relative to a wild-type plant, comprise an increased amount of, or an improved profile of, a compound selected from the group consisting of: glucosinolates (e.g., glucoraphanin (4-methylsulfinylbutyl-glucosinolate), sulforaphane, 3-indolylmethyl-glucosinolate (glucobrassicin), I-methoxy-3-indolylmethyl-glucosinolate (neoglucobrassicin)); phenolics (e.g., flavonoids (e.g., quercetin, kaempferol), hydroxycinnamoyl derivatives (e.g., 1,2,2′-trisinapoylgentiobiose, 1,2-diferuloylgentiobiose, I,2′-disinapoyl-2-feruloylgentiobiose, 3-0-caffeoyl-quinic (neochlorogenic acid)); and vitamins and minerals (e.g., vitamin C, vitamin E, carotene, folic acid, niacin, riboflavin, thiamine, calcium, iron, magnesium, potassium, selenium, and zinc). 
     In another embodiment, herbicide-tolerant plants of the present invention, relative to a wild-type plant, comprise an increased amount of, or an improved profile of, a compound selected from the group consisting of: progoitrin; isothiocyanates; indoles (products of glucosinolate hydrolysis); glutathione; carotenoids such as beta-carotene, lycopene, and the xanthophyll carotenoids such as lutein and zeaxanthin; phenolics comprising the flavonoids such as the flavonols (e.g. quercetin, rutin), the flavans/tannins (such as the procyanidins comprising coumarin, proanthocyanidins, catechins, and anthocyanins); flavones; phytoestrogens such as coumestans, lignans, resveratrol, isoflavones e.g. genistein, daidzein, and glycitein; resorcyclic acid lactones; organosulphur compounds; phytosterols; terpenoids such as carnosol, rosmarinic acid, glycyrrhizin and saponins; chlorophyll; chlorphyllin, sugars, anthocyanins, and vanilla. In other embodiments, herbicide-tolerant plants of the present invention, relative to a wild-type plant, comprise an increased amount of, or an improved profile of, a compound selected from the group consisting of: vincristine, vinblastine, taxanes (e.g., taxol (paclitaxel), baccatin III, 10-desacetylbaccatin III, 10-desacetyl taxol, xylosyl taxol, 7-epitaxol, 7-epibaccatin III, 10-desacetylcephalomannine, 7-epicephalomannine, taxotere, cephalomannine, xylosyl cephalomannine, taxagifine, 8-benxoyloxy taxagifine, 9-acetyloxy taxusin, 9-hydroxy taxusin, taiwanxam, taxane Ia, taxane Ib, taxane Ic, taxane Id, GMP paclitaxel, 9-dihydro 13-acetylbaccatin III, 10-desacetyl-7-epitaxol, tetrahydrocannabinol (THC), cannabidiol (CBD), genistein, diadzein, codeine, morphine, quinine, shikonin, ajmalacine, serpentine, and the like. 
     In other aspects, a method for treating a plant of the present invention is provided. 
     In some embodiments, the method comprises contacting the plant with an agronomically acceptable composition. In one embodiment, the agronomically acceptable composition comprises an auxinic herbicide A. I. 
     In another aspect, the present invention provides a method for preparing a descendent seed. The method comprises planting a seed of or capable of producing a plant of the present invention. In one embodiment, the method further comprises growing a descendent plant from the seed; and harvesting a descendant seed from the descendent plant. In other embodiments, the method further comprises applying a herbicides herbicidal composition to the descendent plant. 
     In another embodiment, the invention refers to harvestable parts of the transgenic plant according to the present invention. Preferably, the harvestable parts comprise the TriA nucleic acid or TriA protein of the present invention. The harvestable parts may be seeds, roots, leaves and/or flowers comprising the TriA nucleic acid or TriA protein or parts thereof. Preferred parts of soy plants are soy beans comprising the TriA nucleic acid or TriA protein. 
     In another embodiment, the invention refers to products derived from a transgenic plant according to the present invention, parts thereof or harvestable parts thereof. A preferred plant product is fodder, seed meal, oil, or seed-treatment-coated seeds. 
     Preferably, the meal and/or oil comprise the TriA nucleic acids or TriA proteins. 
     In another embodiment, the invention refers to a method for the production of a product, which method comprises
     a) growing the plants of the invention or obtainable by the methods of invention and   b) producing said product from or by the plants of the invention and/or parts, e.g. seeds, of these plants.   

     In a further embodiment the method comprises the steps
     a) growing the plants of the invention,   b) removing the harvestable parts as defined above from the plants and   c) producing said product from or by the harvestable parts of the invention.   

     The product may be produced at the site where the plant has been grown, the plants and/or parts thereof may be removed from the site where the plants have been grown to produce the product. Typically, the plant is grown, the desired harvestable parts are removed from the plant, if feasible in repeated cycles, and the product made from the harvestable parts of the plant. The step of growing the plant may be performed only once each time the methods of the invention is performed, while allowing repeated times the steps of product production e.g. by repeated removal of harvestable parts of the plants of the invention and if necessary further processing of these parts to arrive at the product. It is also possible that the step of growing the plants of the invention is repeated and plants or harvestable parts are stored until the production of the product is then performed once for the accumulated plants or plant parts. Also, the steps of growing the plants and producing the product may be performed with an overlap in time, even simultaneously to a large extend or sequentially. Generally the plants are grown for some time before the product is produced. 
     In one embodiment the products produced by said methods of the invention are plant products such as, but not limited to, a foodstuff, feedstuff, a food supplement, feed supplement, fiber, cosmetic and/or pharmaceutical. Foodstuffs are regarded as compositions used for nutrition and/or for supplementing nutrition. Animal feedstuffs and animal feed supplements, in particular, are regarded as foodstuffs. 
     In another embodiment the inventive methods for the production are used to make agricultural products such as, but not limited to, plant extracts, proteins, amino acids, carbohydrates, fats, oils, polymers, vitamins, and the like. 
     It is possible that a plant product consists of one or more agricultural products to a large extent. 
     Herbicides 
     As decribed above, the present invention provides nucleic acids, polypeptides, conferring tolerance of plants to compounds/herbicides interfering or inhibiting cell wall (cellulose) biosynthesis. 
     Examples of herbicides which can be used according to the present invention, i.e. to which the plants according to the present invention are tolerant/resistant to, are compounds known to the skilled artisan as azines. Examples of Azines which are metabolized by the mutated TriA polypeptides of the present invention are described in detail in the following patent applications depicted in the following Table 2. 
     
       
         
           
               
               
             
               
                 TABLE 2 
               
               
                   
               
               
                   
                 Application number/ 
               
               
                   
                 Internal reference; 
               
               
                 Structural Formula 
                 publication number 
               
               
                   
               
             
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 PCT/EP2014/065092 PF75365;  WO2015/007711 Pages 2-7, line 21 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 EP 14162309.0 PF76068;  WO2015/144881 Page 3, line 4-page 5,  line 3 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 EP 14163356.0 PF76069;  WO2015/150541 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 EP 14163742.1 PF76635;  WO2015/155129 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 EP 14163743.9 PF76636; EP2930174 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 EP 14165565.4 PF76857;  WO2015/162166 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 EP 14165624.9 PF76888;  WO2015/162169 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 EP 14164431.0 PF76890;  WO2015/155271 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 EP 14164434.4 PF76930;  WO2015/155272 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 EP 14164433.6 PF77027;  WO2015/155273 
               
               
                   
               
            
           
         
       
     
     Examples of preferred herbicides which can be used according to the present invention are azines having the Formula (I). 
     
       
         
         
             
             
         
       
     
     wherein
     A is phenyl, which is substituted by two to five substituents selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -haloalkynyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)carbonyl, (C 1 -C 6 -alkoxy)carbonyl;   R 1  H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl, (C 1 -C 6 -alkoxy)carbonyl, (C 1 -C 6 -alkyl)sulfonyl or phenylsulfonyl,
       wherein the phenyl is unsubstituted or substituted by one to five substituents selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl and C 1 -C 6 -alkoxy;   
       R 2  H, halogen, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 3 -C 6 -alkynyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl, OH, C 1 -C 6 -alkoxy or C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl;   R 3  H, halogen, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl or C 1 -C 6 -alkoxy;   R 4  H, halogen, CN, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl; or   R 3  and R 4  together with the carbon atom to which they are attached form a moiety selected from the group consisting of carbonyl, C 2 -C 6 -alkenyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl and three- to six-membered heterocyclyl,
       wherein the C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl, or three- to six-membered heterocyclyl is unsubstituted or substituted by one to three substituents selected from halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy; and   
       R 5  H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl, (C 1 -C 6 -alkoxy)carbonyl, (C 1 -C 6 -alkyl)sulfonyl or phenylsulfonyl,
       wherein the phenyl is unsubstituted or substituted by one to five substituents selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl and C 1 -C 6 -alkoxy;   
       

     including their agriculturally acceptable salts or N-oxides. 
     Preferably the present invention provides azines of formula (I), wherein
         A is 2-fluoro-phenyl, which is substituted by one to four substituents selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)carbonyl and (C 1 -C 6 -alkoxy)carbonyl;   R 1  H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl, (C 1 -C 6 -alkoxy)carbonyl, (C 1 -C 6 -alkyl)sulfonyl or phenylsulfonyl,
           wherein the phenyl is unsubstituted or substituted by one to five substituents selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl and C 1 -C 6 -alkoxy;   
           R 2  H, halogen, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 3 -C 6 -alkynyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl, OH, C 1 -C 6 -alkoxy or C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl;   R 3  H, halogen, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl or C 1 -C 6 -alkoxy;   R 4  H, halogen, CN, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl; or   R 3  and R 4  together with the carbon atom to which they are attached form a moiety selected from the group consisting of carbonyl, C 2 -C 6 -alkenyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl and three- to six-membered heterocyclyl,
           wherein the C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl or and three- to six-membered heterocyclyl is unsubstituted or substituted by one to three substituents selected from halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy; and   
           R 5  H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl, (C 1 -C 6 -alkoxy)carbonyl, (C 1 -C 6 -alkyl)sulfonyl or phenylsulfonyl,
           wherein the phenyl is unsubstituted or substituted by one to five substituents selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl and C 1 -C 6 -alkoxy;   
           including their agriculturally acceptable salts or N-oxides.       

     Useful for the present invention are also agrochemical compositions comprising at least one azines of formula (I) and auxiliaries customary for formulating crop protection agents. 
     The present invention also provides the use of azines of formula (I) as herbicides, i.e. for controlling harmful plants. 
     If the azines of formula (I) as described herein are capable of forming geometrical isomers, for example E/Z isomers, it is possible to use both, the pure isomers and mixtures thereof, in the compositions according to the invention. 
     If the azines of formula (I) as described herein have one or more centres of chirality and, as a consequence, are present as enantiomers or diastereomers, it is possible to use both, the pure enantiomers and diastereomers and their mixtures, in the compositions according to the invention. 
     If the azines of formula (I) as described herein have ionizable functional groups, they can also be employed in the form of their agriculturally acceptable salts. Suitable are, in general, the salts of those cations and the acid addition salts of those acids whose cations and anions, respectively, have no adverse effect on the activity of the active compounds. 
     Preferred cations are the ions of the alkali metals, preferably of lithium, sodium and potassium, of the alkaline earth metals, preferably of calcium and magnesium, and of the transition metals, preferably of manganese, copper, zinc and iron, further ammonium and substituted ammonium in which one to four hydrogen atoms are replaced by C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, phenyl or benzyl, preferably ammonium, methylammonium, isopropylammonium, dimethylammonium, diisopropylammonium, trimethylammonium, heptylammonium, dodecylammonium, tetradecylammonium, tetramethylammonium, tetraethylammonium, tetrabutylammonium, 2-hydroxyethylammonium (olamine salt), 2-(2-hydroxyeth-1-oxy)eth-1-ylammonium (diglycolamine salt), di(2-hydroxyeth-1-yl)-ammonium (diolamine salt), tris(2-hydroxyethyl)ammonium (trolamine salt), tris(2-hydroxypropyl)ammonium, benzyltrimethylammonium, benzyltriethylammonium, N,N,N-trimethylethanolammonium (choline salt), furthermore phosphonium ions, sulfonium ions, preferably tri(C 1 -C 4 -alkyl)sulfonium, such as trimethylsulfonium, and sulfoxonium ions, preferably tri(C 1 -C 4 -alkyl)sulfoxonium, and finally the salts of polybasic amines such as N,N-bis-(3-aminopropyl)methylamine and diethylenetriamine. 
     Anions of useful acid addition salts are primarily chloride, bromide, fluoride, iodide, hydrogensulfate, methylsulfate, sulfate, dihydrogenphosphate, hydrogenphosphate, nitrate, bicarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate and also the anions of C 1 -C 4 -alkanoic acids, preferably formate, acetate, propionate and butyrate. 
     The organic moieties mentioned in the definition of the variables, e.g. R 1  to R 5  are—like the term halogen—collective terms for individual enumerations of the individual group members. The term halogen denotes in each case fluorine, chlorine, bromine or iodine. All hydrocarbon chains, i.e. all alkyl, haloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, (alkyl)amino, di(alkyl)amino chains can be straight-chain or branched, the prefix C n -C m  denoting in each case the possible number of carbon atoms in the group. 
     Examples of such meanings are:
         C 1 -C 4 -alkyl: for example CH 3 , C 2 H, n-propyl, CH(CH 3 ) 2 , n-butyl, CH(CH 3 )—C 2 H 5 , CH 2 —CH(CH 3 ) 2  and C(CH 3 ) 3 ;   C 1 -C 6 -alkyl and also the C 1 -C 6 -alkyl moieties of (C 1 -C 6 -alkyl)carbonyl, C 1 -C 6 -alkyoxy-C 1 -C 6 -alkyl: C 1 -C 4 -alkyl as mentioned above, and also, for example, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, n-hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl or 1-ethyl-2-methylpropyl, preferably methyl, ethyl, n-propyl, 1-methylethyl, n-butyl, 1,1-dimethylethyl, n-pentyl or n-hexyl;   C 1 -C 4 -haloalkyl: a C 1 -C 4 -alkyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, for example, chloromethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, bromomethyl, iodomethyl, 2-fluoroethyl, 2-chloroethyl, 2-bromoethyl, 2-iodoethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 2-fluoropropyl, 3-fluoropropyl, 2,2-difluoropropyl, 2,3-difluoropropyl, 2-chloropropyl, 3-chloropropyl, 2,3-dichloropropyl, 2-bromopropyl, 3-bromopropyl, 3,3,3-trifluoropropyl, 3,3,3-trichloropropyl, 2,2,3,3,3-pentafluoropropyl, heptafluoropropyl, 1-(fluoromethyl)-2-fluoroethyl, 1-(chloromethyl)-2-chloroethyl, 1-(bromomethyl)-2-bromoethyl, 4-fluorobutyl, 4-chlorobutyl, 4-bromobutyl, nonafluorobutyl, 1,1,2,2,-tetrafluoroethyl and 1-trifluoromethyl-1,2,2,2-tetrafluoroethyl;   C 1 -C 6 -haloalkyl: C 1 -C 4 -haloalkyl as mentioned above, and also, for example, 5-fluoropentyl, 5-chloropentyl, 5-bromopentyl, 5-iodopentyl, undecafluoropentyl, 6-fluorohexyl, 6-chlorohexyl, 6-bromohexyl, 6-iodohexyl and dodecafluorohexyl;   C 3 -C 6 -cycloalkyl: monocyclic saturated hydrocarbons having 3 to 6 ring members, such as cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl;   C 2 -C 6 -alkenyl: for example ethenyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1-butenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl, 1-ethyl-1-propenyl, 1-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1-pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl, 4-methyl-1-pentenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 1-methyl-3-pentenyl, 2-methyl-3-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-1-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1,3-dimethyl-1-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-1-butenyl, 3,3-dimethyl-2-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl, 1-ethyl-2-methyl-1-propenyl and 1-ethyl-2-methyl-2-propenyl;   C 3 -C 6 -cycloalkenyl: 1-cyclopropenyl, 2-cyclopropenyl, 1-cyclobutenyl, 2-cyclo-butenyl, 1-cyclopentenyl, 2-cyclopentenyl, 1,3-cyclopentadienyl, 1,4-cyclopentadienyl, 2,4-cyclopentadienyl, 1-cyclohexenyl, 2-cyclohexenyl, 3-cyclohexenyl, 1,3-cyclohexa-dienyl, 1,4-cyclohexadienyl, 2,5-cyclohexadienyl;   C 3 -C 6 -alkynyl: for example 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl-2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-1-pentynyl, 3-methyl-4-pentynyl, 4-methyl-1-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl and 1-ethyl-1-methyl-2-propynyl;   C 1 -C 4 -alkoxy: for example methoxy, ethoxy, propoxy, 1-methylethoxy butoxy, 1-methylpropoxy, 2-methylpropoxy and 1,1-dimethylethoxy;   C 1 -C 6 -alkoxy and also the C 1 -C 6 -alkoxy moieties of (C 1 -C 6 -alkoxy)carbonyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl: C 1 -C 4 -alkoxy as mentioned above, and also, for example, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methoxylbutoxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy and 1-ethyl-2-methylpropoxy.   C 1 -C 4 -alkylthio: for example methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio and 1,1-dimethylethylthio;   C 1 -C 6 -alkylthio: C 1 -C 4 -alkylthio as mentioned above, and also, for example, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 2,2-dimethyl-propylthio, 1-ethylpropylthio, hexylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1-methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1-dimethylbutylthio, 1,2-dimethylbutylthio, 1,3-dimethylbutylthio, 2,2-dimethylbutylthio, 2,3-dimethylbutylthio, 3,3-dimethylbutylthio, 1-ethylbutylthio, 2-ethylbutylthio, 1,1,2-trimethylpropylthio, 1,2,2-trimethylpropylthio, 1-ethyl-1-methylpropylthio and 1-ethyl-2-methylpropylthio;   C 1 -C 6 -alkylsulfinyl (C 1 -C 6 -alkyl-S(═O)—): z.B. methylsulfinyl, ethylsulfinyl, propylsulfinyl, 1-methylethylsulfinyl, butylsulfinyl, 1-methylpropylsulfinyl, 2-methylpropylsulfinyl, 1,1-dimethylethylsulfinyl, pentylsulfinyl, 1-methylbutylsulfinyl, 2-methylbutylsulfinyl, 3-methylbutylsulfinyl, 2,2-dimethylpropylsulfinyl, 1-ethylpropylsulfinyl, 1,1-dimethylpropylsulfinyl, 1,2-dimethylpropylsulfinyl, hexylsulfinyl, 1-methylpentylsulfinyl, 2-methylpentylsulfinyl, 3-methylpentylsulfinyl, 4-methylpentyl-sulfinyl, 1,1-dimethylbutylsulfinyl, 1,2-dimethylbutylsulfinyl, 1,3-dimethylbutyl-sulfinyl, 2,2-dimethylbutylsulfinyl, 2,3-dimethylbutylsulfinyl, 3,3-dimethylbutyl-sulfinyl, 1-ethylbutylsulfinyl, 2-ethylbutylsulfinyl, 1,1,2-trimethylpropylsulfinyl, 1,2,2-trimethylpropylsulfinyl, 1-ethyl-1-methylpropylsulfinyl and 1-ethyl-2-methylpropylsulfinyl;   C 1 -C 6 -alkylsulfonyl (C 1 -C 6 -alkyl-S(O) 2 —): for example methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methyl-propylsulfonyl, 1,1-dimethylethylsulfonyl, pentylsulfonyl, 1-methylbutylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, 1,1-dimethylpropylsulfonyl, 1,2-di-methylpropylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylpropylsulfonyl, hexylsulfonyl, 1-methylpentylsulfonyl, 2-methylpentylsulfonyl, 3-methylpentylsulfonyl, 4-methylpentylsulfonyl, 1,1-dimethylbutylsulfonyl, 1,2-dimethylbutylsulfonyl, 1,3-dimethylbutylsulfonyl, 2,2-dimethylbutylsulfonyl, 2,3-dimethylbutylsulfonyl, 3,3-dimethylbutylsulfonyl, 1-ethylbutylsulfonyl, 2-ethylbutylsulfonyl, 1,1,2-trimethyl-propylsulfonyl, 1,2,2-trimethylpropylsulfonyl, 1-ethyl-1-methylpropylsulfonyl and 1-ethyl-2-methylpropylsulfonyl;   (C 1 -C 4 -alkyl)amino: for example methylamino, ethylamino, propylamino, 1-methylethylamino, butylamino, 1-methylpropylamino, 2-methylpropylamino or 1,1-dimethylethylamino;   (C 1 -C 6 -alkyl)amino: (C 1 -C 4 -alkylamino) as mentioned above, and also, for example, pentylamino, 1-methylbutylamino, 2-methylbutylamino, 3-methylbutylamino, 2,2-dimethylpropylamino, 1-ethylpropylamino, hexylamino, 1,1-dimethylpropylamino, 1,2-dimethylpropylamino, 1-methylpentylamino, 2-methylpentylamino, 3-methylpentylamino, 4-methylpentylamino, 1,1-dimethylbutylamino, 1,2-dimethylbutylamino, 1,3-dimethylbutylamino, 2,2-dimethylbutylamino, 2,3-dimethylbutyl-amino 3,3-dimethylbutylamino, 1-ethylbutylamino, 2-ethylbutylamino, 1,1,2-trimethylpropylamino, 1,2,2-trimethyl-propylamino, 1-ethyl-1-methylpropylamino or 1-ethyl-2-methylpropylamino;   di(C 1 -C 4 -alkyl)amino: for example N,N-dimethylamino, N,N-diethylamino, N,N-di(1-methylethyl)amino, N,N-dipropylamino, N,N-dibutylamino, N,N-di(1-methylpropyl)-amino, N,N-di(2-methylpropyl)amino, N,N-di(1,1-dimethylethyl)amino, N-ethyl-N-methylamino, N-methyl-N-propylamino, N-methyl-N-(1-methylethyl)amino, N-butyl-N-methylamino, N-methyl-N-(1-methylpropyl)amino, N-methyl-N-(2-methylpropyl)amino, N-(1,1-dimethylethyl)-N-methylamino, N-ethyl-N-propylamino, N-ethyl-N-(1-methyl-ethyl)amino, N-butyl-N-ethylamino, N-ethyl-N-(1-methylpropyl)amino, N-ethyl-N-(2-methylpropyl)amino, N-ethyl-N-(1,1-dimethylethyl)amino, N-(1-methylethyl)-N-propyl-amino, N-butyl-N-propylamino, N-(1-methylpropyl)-N-propylamino, N-(2-methylpropyl)-N-propylamino, N-(1,1-dimethylethyl)-N-propylamino, N-butyl-N-(1-methylethyl)amino, N-(1-methylethyl)-N-(1-methylpropyl)amino, N-(1-methylethyl)-N-(2-methylpropyl)amino, N-(1,1-dimethylethyl)-N-(1-methylethyl)amino, N-butyl-N-(1-methylpropyl)amino, N-butyl-N-(2-methylpropyl)amino, N-butyl-N-(1,1-dimethylethyl)amino, N-(1-methylpropyl)-N-(2-methylpropyl)amino, N-(1,1-dimethylethyl)-N-(1-methylpropyl)amino or N-(1,1-dimethylethyl)-N-(2-methylpropyl)amino;   di(C 1 -C 6 -alkyl)amino: di(C 1 -C 4 -alkyl)amino as mentioned above, and also, for example, N-methyl-N-pentylamino, N-methyl-N-(1-methylbutyl)amino, N-methyl-N-(2-methylbutyl)amino, N-methyl-N-(3-methylbutyl)amino, N-methyl-N-(2,2-dimethylpropyl)amino, N-methyl-N-(1-ethylpropyl)amino, N-methyl-N-hexylamino, N-methyl-N-(1,1-dimethylpropyl)amino, N-methyl-N-(1,2-dimethylpropyl)amino, N-methyl-N-(1-methylpentyl)amino, N-methyl-N-(2-methylpentyl)amino, N-methyl-N-(3-methylpentyl)amino, N-methyl-N-(4-methylpentyl)amino, N-methyl-N-(1,1-dimethylbutyl)amino, N-methyl-N-(1,2-dimethylbutyl)amino, N-methyl-N-(1,3-dimethylbutyl)amino, N-methyl-N-(2,2-dimethylbutyl)amino, N-methyl-N-(2,3-dimethylbutyl)amino, N-methyl-N-(3,3-dimethylbutyl)amino, N-methyl-N-(1-ethylbutyl)amino, N-methyl-N-(2-ethylbutyl)amino, N-methyl-N-(1,1,2-trimethylpropyl)amino, N-methyl-N-(1,2,2-trimethylpropyl)amino, N-methyl-N-(1-ethyl-1-methylpropyl)amino, N-methyl-N-(1-ethyl-2-methylpropyl)amino, N-ethyl-N-pentylamino, N-ethyl-N-(1-methylbutyl)amino, N-ethyl-N-(2-methylbutyl)amino, N-ethyl-N-(3-methylbutyl)amino, N-ethyl-N-(2,2-dimethylpropyl)amino, N-ethyl-N-(1-ethylpropyl)amino, N-ethyl-N-hexylamino, N-ethyl-N-(1,1-dimethylpropyl)amino, N-ethyl-N-(1,2-dimethylpropyl)amino, N-ethyl-N-(1-methylpentyl)amino, N-ethyl-N-(2-methylpentyl)amino, N-ethyl-N-(3-methylpentyl)amino, N-ethyl-N-(4-methylpentyl)-amino, N-ethyl-N-(1,1-dimethylbutyl)amino, N-ethyl-N-(1,2-dimethylbutyl)amino, N-ethyl-N-(1,3-dimethylbutyl)amino, N-ethyl-N-(2,2-dimethylbutyl)amino, N-ethyl-N-(2,3-dimethylbutyl)amino, N-ethyl-N-(3,3-dimethylbutyl)amino, N-ethyl-N-(1-ethylbutyl)-amino, N-ethyl-N-(2-ethylbutyl)amino, N-ethyl-N-(1,1,2-trimethylpropyl)amino, N-ethyl-N-(1,2,2-trimethylpropyl)amino, N-ethyl-N-(1-ethyl-1-methylpropyl)amino, N-ethyl-N-(1-ethyl-2-methylpropyl)amino, N-propyl-N-pentylamino, N-butyl-N-pentylamino, N,N-dipentylamino, N-propyl-N-hexylamino, N-butyl-N-hexylamino, N-pentyl-N-hexylamino or N,N-dihexylamino;   three- to six-membered heterocyclyl: monocyclic saturated or partially unsaturated hydrocarbon having three to six ring members as mentioned above which, in addition to carbon atoms, contains one or two heteroatoms selected from O, S and N;       

     for example 2-oxiranyl, 2-oxetanyl, 3-oxetanyl, 2-aziridinyl, 3-thietanyl, 1-azetidinyl, 2-azetidinyl, 
     for example 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3-tetra-hydrothienyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-isoxazolidinyl, 4-isoxazolidinyl, 5-isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl, 5-isothiazolidinyl, 3-pyrazolidinyl, 4-pyrazolidinyl, 5-pyrazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5-oxazolidinyl, 2-thiazolidinyl, 4-thiazolidinyl, 5-thiazolidinyl, 2-imidazolidinyl, 4-imidazolidinyl; 
     for example 2,3-dihydrofur-2-yl, 2,3-dihydrofur-3-yl, 2,4-dihydrofur-2-yl, 2,4-dihydrofur-3-yl, 2,3-dihydrothien-2-yl, 2,3-dihydrothien-3-yl, 2,4-dihydrothien-2-yl, 2,4-dihydro-thien-3-yl, 4,5-dihydropyrrol-2-yl, 4,5-dihydropyrrol-3-yl, 2,5-dihydropyrrol-2-yl, 2,5-dihydropyrrol-3-yl, 4,5-dihydroisoxazol-3-yl, 2,5-dihydroisoxazol-3-yl, 2,3-dihydro-isoxazol-3-yl, 4,5-dihydroisoxazol-4-yl, 2,5-dihydroisoxazol-4-yl, 2,3-dihydroisoxazol-4-yl, 4,5-dihydroisoxazol-5-yl, 2,5-dihydroisoxazol-5-yl, 2,3-dihydroisoxazol-5-yl, 4,5-di-hydroisothiazol-3-yl, 2,5-dihydroisothiazol-3-yl, 2,3-dihydroisothiazol-3-yl, 4,5-dihydro-isothiazol-4-yl, 2,5-dihydroisothiazol-4-yl, 2,3-dihydroisothiazol-4-yl, 4,5-dihydroiso-thiazol-5-yl, 2,5-dihydroisothiazol-5-yl, 2,3-dihydroisothiazol-5-yl, 2,3-dihydropyrazol-2-yl, 2,3-dihydropyrazol-3-yl, 2,3-dihydropyrazol-4-yl, 2,3-dihydropyrazol-5-yl, 3,4-dihydro-pyrazol-3-yl, 3,4-dihydropyrazol-4-yl, 3,4-dihydropyrazol-5-yl, 4,5-dihydropyrazol-3-yl, 4,5-dihydropyrazol-4-yl, 4,5-dihydropyrazol-5-yl, 2,3-dihydroimidazol-2-yl, 2,3-di-hydroimidazol-3-yl, 2,3-dihydroimidazol-4-yl, 2,3-dihydroimidazol-5-yl, 4,5-dihydro-imidazol-2-yl, 4,5-dihydroimidazol-4-yl, 4,5-dihydroimidazol-5-yl, 2,5-dihydroimidazol-2-yl, 2,5-dihydroimidazol-4-yl, 2,5-dihydroimidazol-5-yl, 2,3-dihydrooxazol-3-yl, 2,3-di-hydrooxazol-4-yl, 2,3-dihydrooxazol-5-yl, 3,4-dihydrooxazol-3-yl, 3,4-dihydrooxazol-4-yl, 3,4-dihydrooxazol-5-yl, 2,3-dihydrothiazol-3-yl, 2,3-dihydrothiazol-4-yl, 2,3-dihydro-thiazol-5-yl, 3,4-dihydrothiazol-3-yl, 3,4-dihydrothiazol-4-yl, 3,4-dihydrothiazol-5-yl, 3,4-dihydrothiazol-2-yl, 3,4-dihydrothiazol-3-yl, 3,4-dihydrothiazol-4-yl; for example 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 1,3-dioxan-2-yl, 1,3-dioxan-4-yl, 1,3-dioxan-5-yl, 1,4-dioxan-2-yl, 1,3-dithian-2-yl, 1,3-dithian-4-yl, 1,4-dithian-2-yl, 1,3-dithian-5-yl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, 2-tetrahydrothiopyranyl, 3-tetrahydrothiopyranyl, 4-tetrahydro-thiopyranyl, 3-hexahydropyridazinyl, 4-hexahydropyridazinyl, 2-hexahydropyrimidinyl, 4-hexahydropyrimidinyl, 5-hexahydropyrimidinyl, 2-piperazinyl, tetrahydro-1,3-oxazin-2-yl, tetrahydro-1,3-oxazin-6-yl, 2-morpholinyl, 3-morpholinyl; 
     for example 2H-pyran-2-yl, 2H-pyran-3-yl, 2H-pyran-4-yl, 2H-pyran-5-yl, 2H-pyran-6-yl, 3,6-dihydro-2H-pyran-2-yl, 3,6-dihydro-2H-pyran-3-yl, 3,6-dihydro-2H-pyran-4-yl, 3,6-dihydro-2H-pyran-5-yl, 3,6-dihydro-2H-pyran-6-yl, 3,4-dihydro-2H-pyran-3-yl, 3,4-dihydro-2H-pyran-4-yl, 3,4-dihydro-2H-pyran-6-yl, 2H-thiopyran-2-yl, 2H-thiopyran-3-yl, 2H-thiopyran-4-yl, 2H-thiopyran-5-yl, 2H-thiopyran-6-yl, 5,6-dihydro-4H-1,3-oxazin-2-yl; 
     The preferred embodiments of the invention mentioned herein below have to be understood as being preferred either independently from each other or in combination with one another. 
     According to a preferred embodiment of the invention preference is also given to those azines of formula (I), wherein the variables, either independently of one another or in combination with one another, have the following meanings: 
     Preferred are the azines of formula (I), wherein
     A is phenyl, which is substituted by two to five substituents selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)carbonyl, (C 1 -C 6 -alkoxy)carbonyl;
       particularly preferred phenyl, which is substituted by two to five substituents
           selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   particularly preferred selected from halogen and CN;   also particularly preferred selected from the group consisting of F, Cl, CN and CH 3 ;   especially preferred selected from the group consisting of F, Cl and CN;   
           especially preferred phenyl, which is substituted by two to four substituents
           selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl;   particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN;   
           more preferred phenyl, which is substituted by two substituents
           selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl;   particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN;   
           also more preferred phenyl, which is substituted by three substituents
           selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl;   particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN;   
           also more preferred phenyl, which is substituted by four substituents
           selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl;   particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN.   
           
       

     Also preferred are the azines of formula (I), wherein
     A is   

     
       
         
         
             
             
         
       
         
         
           
             wherein 
             R a  and R e  independently of one another are halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl; and 
             R b , R c  and R d  independently of one another are hydrogen, halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)carbonyl, (C 1 -C 6 -alkoxy)carbonyl; 
             particularly preferred R a  and R e  independently of one another are halogen, CN, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy; and
           R b , R c  and R d  independently of one another are hydrogen, halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl or C 1 -C 6 -alkoxy;   
         
             especially preferred R a  and R e  independently of one another are halogen or CN; and
           R b , R c  and R d  independently of one another are hydrogen, halogen, CN, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy;   
         
             more preferred R a  and R e  are halogen; and
           R b , R c  and R d  independently of one another are hydrogen, halogen or CN;   
         
             most preferred R a  and R e  are halogen; and
           R b , R c  and R d  are hydrogen;   
         
             also most preferred R a , R b , R d  and R e  are halogen; and
           R c  hydrogen;   
         
             also most preferred R a , R b , R c , R d  and R e  are halogen. 
           
         
       
    
     Also preferred are the azines of formula (I), wherein
     A is   

     
       
         
         
             
             
         
       
         
         
           
             wherein R a  is halogen or CN;
           R b  and R d  are H, halogen or CN;   R c  is H or halogen;   R e  is halogen, CN or C 1 -C 6 -alkyl;   
         
             particularly preferred R a  is halogen;
           R b , R c  and R d  are H or halogen; and   R e  is halogen or CN;   
         
             especially preferred R a , R b , R d  and R e  are halogen; and
           R c  is H or halogen;   
         
             more preferred R a , R b , R d  and R e  are F; and
           R c  is H or F.   
         
           
         
       
    
     Especially preferred are the azines of formula (I), wherein A is selected from the group consisting of (A.1.1), (A.1.2) and (A.1.3); 
     more preferred selected from the group consisting of (A.1.2) and (A.1.3); 
     
       
         
         
             
             
         
       
         
         
           
             wherein 
             R a  and R e  independently of one another are halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl; and 
             R b  and R d  independently of one another are halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl; 
             particularly preferred R a  and R e  independently of one another are halogen, CN, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy; and
           R b  and R d  independently of one another are halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl or C 1 -C 6 -alkoxy;   
         
             especially preferred R a  and R e  independently of one another halogen or CN; and
           R b  and R d  independently of one another are halogen, CN, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy;   
         
             more preferred R a  and R e  are halogen; and
           R b  and R d  independently of one another are halogen or CN;   
         
             most preferred R a , R b , R d  and R e  are halogen. 
           
         
       
    
     Also especially preferred are the azines of formula (I), wherein
     A is   

     
       
         
         
             
             
         
       
         
         
           
             wherein R a , R b , R d  and R e  have the meanings, in particular the preferred meanings, as defined above. 
           
         
       
    
     Also especially preferred are the azines of formula (I), wherein
     A is   

     
       
         
         
             
             
         
       
         
         
           
             wherein R a , R b  and R e  have the meanings, in particular the preferred meanings, as defined above. 
           
         
       
    
     Also especially preferred are the azines of formula (I), wherein
     A is   

     
       
         
         
             
             
         
       
         
         
           
             wherein R a  and R e  have the meanings, in particular the preferred meanings, as defined above. 
           
         
       
    
     Also preferred are the azines of formula (I), wherein
     A is 2-fluoro-phenyl, which is substituted by one to four substituents selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)carbonyl and (C 1 -C 6 -alkoxy)-carbonyl;
       particularly preferrd 2-fluoro-phenyl, which is substituted by one to four substituents
           selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   particularly preferred selected from halogen and CN;   also particularly preferred selected from the group consisting of F, Cl, CN and CH 3 ;   especially preferred selected from the group consisting of F, Cl and CN;   
           especially preferred 2-fluoro-phenyl, which is substituted by one to three substituents
           selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl and (C 1 -C 6 -alkoxy)carbonyl;   particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN;   
           more preferred 2-fluoro-phenyl, which is substituted by one substituent
           selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl and (C 1 -C 6 -alkoxy)carbonyl;   particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN;   
           also more preferred 2-fluoro-phenyl, which is substituted by two substituents
           selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl and (C 1 -C 6 -alkoxy)carbonyl;   particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN;   
           also more preferred 2-fluoro-phenyl, which is substituted by three substituents
           selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl and (C 1 -C 6 -alkoxy)carbonyl;   particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN.   
           
       

     Also preferred are the azines of formula (I), wherein
     A is   

     
       
         
         
             
             
         
       
         
         
           
             wherein 
             R a  is halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)-amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)carbonyl, (C 1 -C 6 -alkoxy)carbonyl; and 
             R b , R c  and R d  independently of one another are hydrogen, halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)carbonyl, (C 1 -C 6 -alkoxy)carbonyl; 
             particularly preferred R a  is halogen, CN, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy; and
           R b , R c  and R d  independently of one another are hydrogen, halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl or C 1 -C 6 -alkoxy;   
         
             especially preferred R a  is halogen or CN; and
           R b , R c  and R d  independently of one another are hydrogen, halogen, CN, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy;   
         
             more preferred R a  is halogen; and
           R b , R c  and R d  independently of one another are hydrogen, halogen or CN;   
         
             most preferred R a  is halogen; and
           R b , R c  and R d  are hydrogen;   
         
             also most preferred R a , R b  and R d  are halogen; and
           R c  is hydrogen;   
         
             also most preferred R a , R b , R c  and R d  are halogen. 
           
         
       
    
     Also preferred are the azines of formula (I), wherein 
     A is 
     
       
         
         
             
             
         
       
         
         
           
             wherein R a  is halogen, CN or C 1 -C 6 -alkyl;
           R b  and R d  are H, halogen or CN; and   R c  is H or halogen;   
         
             particularly preferred R a  is halogen or CN; and
           R b , R c  and R d  are H or halogen;   
         
             especially preferred R a , R b  and R d  are halogen; and
           R c  is H or halogen;   
         
             Also especially preferred R a , R b  and R d  are halogen; and
           R c  is H, F, Br or 1;   
         
             more preferred R a , R b  and R d  are F; and
           R c  is F, Br or 1;   
         
             also more preferred R a , R b  and R d  are F; and
           R c  is H or F.   
         
           
         
       
    
     Especially preferred are the azines of formula (I), wherein A is selected from the group consisting of (A.1a.1), (A.1a.2) and (A.1a.3); 
     more preferred selected from the group consisting of (A.1.2) and (A.1.3); 
     
       
         
         
             
             
         
       
         
         
           
             wherein 
             R a  is halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)-amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)carbonyl, (C 1 -C 6 -alkoxy)carbonyl; and 
             R b  and R d  independently of one another are halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl; 
             particularly preferred R a  is halogen, CN, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy; and
           R b  and R d  independently of one another are halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl or C 1 -C 6 -alkoxy;   
         
             especially preferred R a  is halogen or CN; and
           R b  and R d  independently of one another are halogen, CN, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy;   
         
             more preferred R a  is halogen; and
           R b  and R d  independently of one another are halogen or CN;   
         
             most preferred R a , R b  and R d  are halogen. 
           
         
       
    
     Also especially preferred are the azines of formula (I), wherein
     A is   

     
       
         
         
             
             
         
       
         
         
           
             wherein R a , R b  and R d  have the meanings, in particular the preferred meanings, as defined above. 
           
         
       
    
     Also especially preferred are the azines of formula (I), wherein
     A is   

     
       
         
         
             
             
         
       
         
         
           
             wherein R a  and R b  have the meanings, in particular the preferred meanings, as defined above. 
           
         
       
    
     Also especially preferred are the azines of formula (I), wherein
     A is   

     
       
         
         
             
             
         
       
         
         
           
             wherein R a  has the meanings, in particular the preferred meanings, as defined above. 
           
         
       
    
     Also preferred are the azines of formula (I), wherein
     R 1  is H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl or (C 1 -C 6 -alkyl)sulfonyl;
       particularly preferred H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl or (C 1 -C 6 -alkyl)sulfonyl;   especially preferred H, CN, CH 3 , CH 2 OCH 3 , OCH 3 , COCH 3  or SO 2 CH 3 ; more preferred hydrogen.   
       

     Also preferred are the azines of formula (I), wherein
     R 2  is H, halogen, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl;
       particularly preferred halogen, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl;   also particularly preferred H, F, Cl, CH 3  or CF 3 .   
       

     Also preferred are the azines of formula (I), wherein
     R 3  and R 4  are
       independently of one another H, halogen, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl; or together with the carbon atom to which they are attached form a moiety selected from the group consisting of C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl and three- to six-membered heterocyclyl,
           wherein the C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl or the three- to six-membered heterocyclyl is unsubstituted or substituted by one to three substituents selected from halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   
           independently of one another particularly preferred H, halogen, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl; or   together with the carbon atom to which they are attached form a moiety selected from the group consisting of C 3 -C 6 -cycloalkyl and C 3 -C 6 -cycloalkenyl,
           wherein the C 3 -C 6 -cycloalkyl or C 3 -C 6 -cycloalkenyl is unsubstituted or substituted by one to three substituents selected from halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   
           independently of one another especially preferred H, halogen, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl;   independently of one another more preferred H, halogen or C 1 -C 6 -alkyl.   
       

     Also preferred are the azines of formula (I), wherein
         R 2  is H, halogen, C 1 -C 6 -alkyl; and   R 3  and R 4  are independently of one another H, halogen, C 1 -C 6 -alkyl, or together with the carbon atom to which they are attached form a C 3 -C 6 -cycloalkyl;   particularly preferred R 2  is H, halogen or C 1 -C 6 -alkyl;
           R 3  is C 1 -C 6 -alkyl;   R 4  is H, halogen or C 1 -C 6 -alkyl;   R 3  and R 4  together with the carbon atom to which they are attached form a C 3 -C 6 -cycloalkyl;   
           especially preferred R 2  is halogen or C 1 -C 6 -alkyl;
           R 3  is C 1 -C 6 -alkyl;   R 4  is H or C 1 -C 6 -alkyl;   
           more preferred R 2  is halogen; and
           R 3  and R 4  are C 1 -C 6 -alkyl.   
               

     Also preferred are the azines of formula (I), wherein
     R 5  is H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl or (C 1 -C 6 -alkyl)sulfonyl;
       particularly preferred H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl or (C 1 -C 6 -alkyl)sulfonyl;   especially preferred H, CN, CH 3 , CH 2 OCH 3 , OCH 3 , COCH 3  or SO 2 CH 3 ; more preferred hydrogen.   
       

     Also preferred are the azines of formula (I), wherein
     A is phenyl, which is substituted by two to five substituents
       selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   particularly preferred selected from halogen and CN;   also particularly preferred selected from the group consisting of F, Cl, CN and CH 3 ;   especially preferred selected from the group consisting of F, Cl and CN;   particularly preferred phenyl, which is substituted by two to four substituents selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl;
           particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN;   
           especially preferred phenyl, which is substituted by two substituents
           selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl;   particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN;   
           also especially preferred phenyl, which is substituted by three substituents
           selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl;   particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN;   
           also specially preferred phenyl, which is substituted by four substituents
           selected from the group consisting of halogen, CN, NO 2 , C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, OH, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, (C 1 -C 6 -alkyl)sulfinyl, (C 1 -C 6 -alkyl)sulfonyl, amino, (C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkyl)amino, (C 1 -C 6 -alkyl)-carbonyl, (C 1 -C 6 -alkoxy)carbonyl;   particularly preferred selected from the group consisting of halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   especially preferred selected from halogen and CN;   also especially preferred selected from the group consisting of F, Cl, CN and CH 3 ;   more preferred selected from the group consisting of F, Cl and CN;   
           
       R 1  is H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl or (C 1 -C 6 -alkyl)sulfonyl;
       particularly preferred H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl or (C 1 -C 6 -alkyl)sulfonyl;   especially preferred H, CN, CH 3 , CH 2 OCH 3 , OCH 3 , COCH 3  or SO 2 CH 3 ;   more preferred hydrogen.   
       R 2  is H, halogen, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl;
       particularly preferred halogen, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl;   also particularly preferred H, F, CH 3  or CF 3 ;   
       R 3  and R 4  are independently of one another H, halogen, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl; or
       together with the carbon atom to which they are attached form a moiety selected from the group consisting of C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl and three- to six-membered heterocyclyl,
           wherein the C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkenyl or the three- to six-membered heterocyclyl is unsubstituted or substituted by one to three substituents selected from halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   
           independently of one another particularly preferred H, halogen, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl; or   together with the carbon atom to which they are attached form a moiety selected from the group consisting of C 3 -C 6 -cycloalkyl and C 3 -C 6 -cycloalkenyl,
           wherein the C 3 -C 6 -cycloalkyl or C 3 -C 6 -cycloalkenyl is unsubstituted or substituted by one to three substituents selected from halogen, CN, C 1 -C 6 -alkyl and C 1 -C 6 -alkoxy;   
           independently of one another especially preferred H, halogen, C 1 -C 6 -alkyl or C 1 -C 6 -haloalkyl;   independently of one another more preferred H, halogen or C 1 -C 6 -alkyl;
 
and
   
       R 5  is H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl or (C 1 -C 6 -alkyl)sulfonyl;
       particularly preferred H, CN, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, (C 1 -C 6 -alkyl)carbonyl or (C 1 -C 6 -alkyl)sulfonyl;   especially preferred H, CN, CH 3 , CH 2 OCH 3 , OCH 3 , COCH 3  or SO 2 CH 3 ; more preferred hydrogen.   
       

     Particular preference is given to azines of formula (I.a), which correspond to azines of formula (I) wherein A is (A.1) and R 1  and R 5  are H: 
     
       
         
         
             
             
         
       
         
         
           
             wherein the variables R e , R b , R c , R d , R e , R 2 , R 3  and R 4  have the meanings, in particular the preferred meanings, as defined above; 
           
         
       
    
     special preference is given to the azines of the formulae (I.a.1) to (I.a.1406) of Table A, where the definitions of the variables R e , R b , R c , R d , R e , R 2 , R 3  and R 4  are of particular importance for the compounds according to the invention not only in combination with one another but in each case also on their own: 
     
       
         
           
               
               
               
               
               
               
               
               
               
             
               
                 TABLE A 
               
               
                   
               
               
                 No. 
                 R a   
                 R b   
                 R c   
                 R d   
                 R e   
                 R 2   
                 R 3   
                 R 4   
               
               
                   
               
             
            
               
                 I.a.1 
                 F 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.2 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.3 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.4 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.5 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.6 
                 F 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.7 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.8 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.9 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.10 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.11 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.12 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.13 
                 F 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.14 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.15 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.16 
                 F 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.17 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.18 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.19 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.20 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.21 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.22 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.23 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.24 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.25 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.26 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.27 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.28 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.29 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.30 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.31 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.32 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.33 
                 H 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.34 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.35 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.36 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.37 
                 F 
                 F 
                 I 
                 F 
                 F 
                 CH 3   
                 H 
                 H 
               
               
                 I.a.38 
                 F 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.39 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.40 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.41 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.42 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.43 
                 F 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.44 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.45 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.46 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.47 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.48 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.49 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.50 
                 F 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.51 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.52 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.53 
                 F 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.54 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.55 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.56 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.57 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.58 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.59 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.60 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.61 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.62 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.63 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.64 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.65 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.66 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.67 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.68 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.69 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.70 
                 H 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.71 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.72 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.73 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.74 
                 F 
                 F 
                 I 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 H 
               
               
                 I.a.75 
                 F 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.76 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.77 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.78 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.79 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.80 
                 F 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.81 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.82 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.83 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.84 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.85 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.86 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.87 
                 F 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.88 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.89 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.90 
                 F 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.91 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.92 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.93 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.94 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.95 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.96 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.97 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.98 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.99 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.100 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.101 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.102 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.103 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.104 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.105 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.106 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.107 
                 H 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.108 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.109 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.110 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.111 
                 F 
                 F 
                 I 
                 F 
                 F 
                 CH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.112 
                 F 
                 H 
                 H 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.113 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.114 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.115 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.116 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.117 
                 F 
                 H 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.118 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.119 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.120 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.121 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.122 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.123 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.124 
                 F 
                 H 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.125 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.126 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.127 
                 F 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.128 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.129 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.130 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.131 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.132 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.133 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.134 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.135 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.136 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.137 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.138 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.139 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.140 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.141 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.142 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.143 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.144 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.145 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.146 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.147 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.148 
                 F 
                 F 
                 I 
                 F 
                 F 
                 F 
                 F 
                 F 
               
               
                 I.a.149 
                 F 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.150 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.151 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.152 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.153 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.154 
                 F 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.155 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.156 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.157 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.158 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.159 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.160 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.161 
                 F 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.162 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.163 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.164 
                 F 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.165 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.166 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.167 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.168 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.169 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.170 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.171 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.172 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.173 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.174 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.175 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.176 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.177 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.178 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.179 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.180 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.181 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.182 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.183 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.184 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.185 
                 F 
                 F 
                 I 
                 F 
                 F 
                 F 
                 CF 3   
                 F 
               
               
                 I.a.186 
                 F 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.187 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.188 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.189 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.190 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.191 
                 F 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.192 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.193 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.194 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.195 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.196 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.197 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.198 
                 F 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.199 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.200 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.201 
                 F 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.202 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.203 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.204 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.205 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.206 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.207 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.208 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.209 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.210 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.211 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.212 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.213 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.214 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.215 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.216 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.217 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.218 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.219 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.220 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.221 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.222 
                 F 
                 F 
                 I 
                 F 
                 F 
                 F 
                 CH 3   
                 F 
               
               
                 I.a.223 
                 F 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.224 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.225 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.226 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.227 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.228 
                 F 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.229 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.230 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.231 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.232 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.233 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.234 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.235 
                 F 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.236 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.237 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.238 
                 F 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.239 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.240 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.241 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.242 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.243 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.244 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.245 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.246 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.247 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.248 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.249 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.250 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.251 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.252 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.253 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.254 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.255 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.256 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.257 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.258 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.259 
                 F 
                 F 
                 I 
                 F 
                 F 
                 F 
                 CH 3   
                 H 
               
               
                 I.a.260 
                 F 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.261 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.262 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.263 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.264 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.265 
                 F 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.266 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.267 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.268 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.269 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.270 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.271 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.272 
                 F 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.273 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.274 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.275 
                 F 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.276 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.277 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.278 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.279 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.280 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.281 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.282 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.283 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.284 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.285 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.286 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.287 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.288 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.289 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.290 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.291 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.292 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.293 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.294 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.295 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.296 
                 F 
                 F 
                 I 
                 F 
                 F 
                 F 
                 CH 3   
                 CH 3   
               
               
                 I.a.297 
                 F 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.298 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.299 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.300 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.301 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.302 
                 F 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.303 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.304 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.305 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.306 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.307 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.308 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.309 
                 F 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.310 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.311 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.312 
                 F 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.313 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.314 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.315 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.316 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.317 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.318 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.319 
                 F 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.320 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.321 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.322 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.323 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.324 
                 F 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.325 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.326 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.327 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.328 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.329 
                 H 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.330 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.331 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.332 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.333 
                 F 
                 F 
                 I 
                 F 
                 F 
                 Cl 
                 CH 3   
                 CH 3   
               
               
                 I.a.334 
                 F 
                 H 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.335 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.336 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.337 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.338 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.339 
                 F 
                 H 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.340 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.341 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.342 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.343 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.344 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.345 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.346 
                 F 
                 H 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.347 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.348 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.349 
                 F 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.350 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.351 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.352 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.353 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.354 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.355 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.356 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.357 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.358 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.359 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.360 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.361 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.362 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.363 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.364 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.365 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.366 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.367 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.368 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.369 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.370 
                 F 
                 F 
                 1 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.371 
                 F 
                 H 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.372 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.373 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.374 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.375 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.376 
                 F 
                 H 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.377 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.378 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.379 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.380 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.381 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.382 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.383 
                 F 
                 H 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.384 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.385 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.386 
                 F 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.387 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.388 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.389 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.390 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.391 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.392 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.393 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.394 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.395 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.396 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.397 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.398 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.399 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.400 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.401 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.402 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.403 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.404 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.405 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.406 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
               
                 I.a.407 
                 F 
                 F 
                 I 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 I.a.408 
                 F 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.409 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.410 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.411 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.412 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.413 
                 F 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.414 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.415 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.416 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.417 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.418 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.419 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.420 
                 F 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.421 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.422 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.423 
                 F 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.424 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.425 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.426 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.427 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.428 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.429 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.430 
                 F 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.431 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.432 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.433 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.434 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.435 
                 F 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.436 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.437 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.438 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.439 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.440 
                 H 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.441 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.442 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.443 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.444 
                 F 
                 F 
                 I 
                 F 
                 F 
                 H 
                 —(CH 2 ) 2 — 
               
               
                 I.a.445 
                 F 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.446 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.447 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.448 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.449 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.450 
                 F 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.451 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.452 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.453 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.454 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.455 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.456 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.457 
                 F 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.458 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.459 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.460 
                 F 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.461 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.462 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.463 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.464 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.465 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.466 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.467 
                 F 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.468 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.469 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.470 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.471 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.472 
                 F 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.473 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.474 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.475 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.476 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.477 
                 H 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.478 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.479 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.480 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.481 
                 F 
                 F 
                 I 
                 F 
                 F 
                 H 
                 —(CH 2 ) 3 — 
               
               
                 I.a.482 
                 F 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.483 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.484 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.485 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.486 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.487 
                 F 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.488 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.489 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.490 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.491 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.492 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.493 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.494 
                 F 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.495 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.496 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.497 
                 F 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.498 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.499 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.500 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.501 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.502 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.503 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.504 
                 F 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.505 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.506 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.507 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.508 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.509 
                 F 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.510 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.511 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.512 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.513 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.514 
                 H 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.515 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.516 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.517 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.518 
                 F 
                 F 
                 I 
                 F 
                 F 
                 H 
                 —(CH 2 ) 4 — 
               
               
                 I.a.519 
                 F 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.520 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.521 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.522 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.523 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.524 
                 F 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.525 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.526 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.527 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.528 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.529 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.530 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.531 
                 F 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.532 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.533 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.534 
                 F 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.535 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.536 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.537 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.538 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.539 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.540 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.541 
                 F 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.542 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.543 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.544 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.545 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.546 
                 F 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.547 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.548 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.549 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.550 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.551 
                 H 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.552 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.553 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.554 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.555 
                 F 
                 F 
                 I 
                 F 
                 F 
                 H 
                 —(CH 2 ) 5 — 
               
               
                 I.a.556 
                 F 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.557 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.558 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.559 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.560 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.561 
                 F 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.562 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.563 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.564 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.565 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.566 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.567 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.568 
                 F 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.569 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.570 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.571 
                 F 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.572 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.573 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.574 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.575 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.576 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.577 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.578 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.579 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.580 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.581 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.582 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.583 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.584 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.585 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.586 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.587 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.588 
                 H 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.589 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.590 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.591 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.592 
                 F 
                 F 
                 1 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 2 — 
               
               
                 I.a.593 
                 F 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.594 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.595 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.596 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.597 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.598 
                 F 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.599 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.600 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.601 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.602 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.603 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.604 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.605 
                 F 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.606 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.607 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.608 
                 F 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.609 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.610 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.611 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.612 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.613 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.614 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.615 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.616 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.617 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.618 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.619 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.620 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.621 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.622 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.623 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.624 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.625 
                 H 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.626 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.627 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.628 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.629 
                 F 
                 F 
                 I 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 3 — 
               
               
                 I.a.630 
                 F 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.631 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.632 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.633 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.634 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.635 
                 F 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.636 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.637 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.638 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.639 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.640 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.641 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.642 
                 F 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.643 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.644 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.645 
                 F 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.646 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.647 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.648 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.649 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.650 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.651 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.652 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.653 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.654 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.655 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.656 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.657 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.658 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.659 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.660 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.661 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.662 
                 H 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.663 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.664 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.665 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.666 
                 F 
                 F 
                 I 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 4 — 
               
               
                 I.a.667 
                 F 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.668 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.669 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.670 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.671 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.672 
                 F 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.673 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.674 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.675 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.676 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.677 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.678 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.679 
                 F 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.680 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.681 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.682 
                 F 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.683 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.684 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.685 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.686 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.687 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.688 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.689 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.690 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.691 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.692 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.693 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.694 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.695 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.696 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.697 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.698 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.699 
                 H 
                 F 
                 F 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.700 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.701 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.702 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.703 
                 F 
                 F 
                 I 
                 F 
                 F 
                 CH 3   
                 —(CH 2 ) 5 — 
               
               
                 I.a.704 
                 F 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.705 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.706 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.707 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.708 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.709 
                 F 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.710 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.711 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.712 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.713 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.714 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.715 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.716 
                 F 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.717 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.718 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.719 
                 F 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.720 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.721 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.722 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.723 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.724 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.725 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.726 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.727 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.728 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.729 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.730 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.731 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.732 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.733 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.734 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.735 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.736 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.737 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.738 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.739 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.740 
                 F 
                 F 
                 I 
                 F 
                 F 
                 F 
                 —(CH 2 ) 2 — 
               
               
                 I.a.741 
                 F 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.742 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.743 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.744 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.745 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.746 
                 F 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.747 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.748 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.749 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.750 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.751 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.752 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.753 
                 F 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.754 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.755 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.756 
                 F 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.757 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.758 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.759 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.760 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.761 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.762 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.763 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.764 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.765 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.766 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.767 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.768 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.769 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.770 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.771 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.772 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.773 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.774 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.775 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.776 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.777 
                 F 
                 F 
                 I 
                 F 
                 F 
                 F 
                 —(CH 2 ) 3 — 
               
               
                 I.a.778 
                 F 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.779 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.780 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.781 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.782 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.783 
                 F 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.784 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.785 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.786 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.787 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.788 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.789 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.790 
                 F 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.791 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.792 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.793 
                 F 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.794 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.795 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.796 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.797 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.798 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.799 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.800 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.801 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.802 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.803 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.804 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.805 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.806 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.807 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.808 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.809 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.810 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.811 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.812 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.813 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.814 
                 F 
                 F 
                 I 
                 F 
                 F 
                 F 
                 —(CH 2 ) 4 — 
               
               
                 I.a.815 
                 F 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.816 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.817 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.818 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.819 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.820 
                 F 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.821 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.822 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.823 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.824 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.825 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.826 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.827 
                 F 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.828 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.829 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.830 
                 F 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.831 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.832 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.833 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.834 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.835 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.836 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.837 
                 F 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.838 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.839 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.840 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.841 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.842 
                 F 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.843 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.844 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.845 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.846 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.847 
                 H 
                 F 
                 F 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.848 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.849 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.850 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.851 
                 F 
                 F 
                 I 
                 F 
                 F 
                 F 
                 —(CH 2 ) 5 — 
               
               
                 I.a.852 
                 F 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.853 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.854 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.855 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.856 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.857 
                 F 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.858 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.859 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.860 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.861 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.862 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.863 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.864 
                 F 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.865 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.866 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.867 
                 F 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.868 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.869 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.870 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.871 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.872 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.873 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.874 
                 F 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.875 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.876 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.877 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.878 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.879 
                 F 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.880 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.881 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.882 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.883 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.884 
                 H 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.885 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.886 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.887 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.888 
                 F 
                 F 
                 I 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 2 — 
               
               
                 I.a.889 
                 F 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.890 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.891 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.892 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.893 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.894 
                 F 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.895 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.896 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.897 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.898 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.899 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.900 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.901 
                 F 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.902 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.903 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.904 
                 F 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.905 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.906 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.907 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.908 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.909 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.910 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.911 
                 F 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.912 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.913 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.914 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.915 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.916 
                 F 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.917 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.918 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.919 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.920 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.921 
                 H 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.922 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.923 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.924 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.925 
                 F 
                 F 
                 I 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 3 — 
               
               
                 I.a.926 
                 F 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.927 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.928 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.929 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.930 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.931 
                 F 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.932 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.933 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.934 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.935 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.936 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.937 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.938 
                 F 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.939 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.940 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.941 
                 F 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.942 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.943 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.944 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.945 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.946 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.947 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.948 
                 F 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.949 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.950 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.951 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.952 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.953 
                 F 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.954 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.955 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.956 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.957 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.958 
                 H 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.959 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.960 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.961 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.962 
                 F 
                 F 
                 I 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 4 — 
               
               
                 I.a.963 
                 F 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.964 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.965 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.966 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.967 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.968 
                 F 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.969 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.970 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.971 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.972 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.973 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.974 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.975 
                 F 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.976 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.977 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.978 
                 F 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.979 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.980 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.981 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.982 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.983 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.984 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.985 
                 F 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.986 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.987 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.988 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.989 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.990 
                 F 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.991 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.992 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.993 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.994 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.995 
                 H 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.996 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.997 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.998 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
               
                 I.a.999 
                 F 
                 F 
                 I 
                 F 
                 F 
                 Cl 
                 —(CH 2 ) 5 — 
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 I.a.1000 
                 F 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1001 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1002 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1003 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1004 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1005 
                 F 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1006 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1007 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1008 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1009 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1010 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1011 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1012 
                 F 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1013 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1014 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1015 
                 F 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1016 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1017 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1018 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1019 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1020 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1021 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1022 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1023 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1024 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1025 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1026 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1027 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1028 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1029 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1030 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1031 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1032 
                 H 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1033 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1034 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1035 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1036 
                 F 
                 F 
                 I 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 H 
               
               
                 I.a.1037 
                 F 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1038 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1039 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1040 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1041 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1042 
                 F 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1043 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1044 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1045 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1046 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1047 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1048 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1049 
                 F 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1050 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1051 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1052 
                 F 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1053 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1054 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1055 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1056 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1057 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1058 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1059 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1060 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1061 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1062 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1063 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1064 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1065 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1066 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1067 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1068 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1069 
                 H 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1070 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1071 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1072 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1073 
                 F 
                 F 
                 I 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 H 
               
               
                 I.a.1074 
                 F 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1075 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1076 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1077 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1078 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1079 
                 F 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1080 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1081 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1082 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1083 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1084 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1085 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1086 
                 F 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1087 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1088 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1089 
                 F 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1090 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1091 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1092 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1093 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1094 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1095 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1096 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1097 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1098 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1099 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1100 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1101 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1102 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1103 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1104 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1105 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1106 
                 H 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1107 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1108 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1109 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1110 
                 F 
                 F 
                 I 
                 F 
                 F 
                 C 2 H 5   
                 C 2 H 5   
                 CH 3   
               
               
                 I.a.1111 
                 F 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1112 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1113 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1114 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1115 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1116 
                 F 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1117 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1118 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1119 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1120 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1121 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1122 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1123 
                 F 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1124 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1125 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1126 
                 F 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1127 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1128 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1129 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1130 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1131 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1132 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1133 
                 F 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1134 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1135 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1136 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1137 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1138 
                 F 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1139 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1140 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1141 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1142 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1143 
                 H 
                 F 
                 F 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1144 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1145 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1146 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1147 
                 F 
                 F 
                 I 
                 F 
                 F 
                 C 2 H 5   
                 CH 3   
                 CH 3   
               
               
                 I.a.1148 
                 F 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1149 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1150 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1151 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1152 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1153 
                 F 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1154 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1155 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1156 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1157 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1158 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1159 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1160 
                 F 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1161 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1162 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1163 
                 F 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1164 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1165 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1166 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1167 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1168 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1169 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1170 
                 F 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1171 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1172 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1173 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1174 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1175 
                 F 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1176 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1177 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1178 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1179 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1180 
                 H 
                 F 
                 F 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1181 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1182 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1183 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1184 
                 F 
                 F 
                 1 
                 F 
                 F 
                 Cl 
                 CH 3   
                 H 
               
               
                 I.a.1185 
                 F 
                 H 
                 H 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1186 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1187 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1188 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1189 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1190 
                 F 
                 H 
                 H 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1191 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1192 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1193 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1194 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1195 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1196 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1197 
                 F 
                 H 
                 F 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1198 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1199 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1200 
                 F 
                 F 
                 F 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1201 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1202 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1203 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1204 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1205 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1206 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1207 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1208 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1209 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1210 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1211 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1212 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1213 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1214 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1215 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1216 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1217 
                 H 
                 F 
                 F 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1218 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1219 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1220 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1221 
                 F 
                 F 
                 I 
                 F 
                 F 
                 CH 2 Cl 
                 Cl 
                 CH 3   
               
               
                 I.a.1222 
                 F 
                 H 
                 H 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1223 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1224 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1225 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1226 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1227 
                 F 
                 H 
                 H 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1228 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1229 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1230 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1231 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1232 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1233 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1234 
                 F 
                 H 
                 F 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1235 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1236 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1237 
                 F 
                 F 
                 F 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1238 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1239 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1240 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1241 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1242 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1243 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1244 
                 F 
                 F 
                 H 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1245 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1246 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1247 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1248 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1249 
                 F 
                 F 
                 F 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1250 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1251 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1252 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1253 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1254 
                 H 
                 F 
                 F 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1255 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1256 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1257 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1258 
                 F 
                 F 
                 1 
                 F 
                 F 
                 CN 
                 CH 3   
                 CH 3   
               
               
                 I.a.1259 
                 F 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1260 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1261 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1262 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1263 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1264 
                 F 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1265 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1266 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1267 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1268 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1269 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1270 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1271 
                 F 
                 H 
                 F 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1272 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1273 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1274 
                 F 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1275 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1276 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1277 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1278 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1279 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1280 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1281 
                 F 
                 F 
                 H 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1282 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1283 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1284 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1285 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1286 
                 F 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1287 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1288 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1289 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1290 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1291 
                 H 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1292 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1293 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1294 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1295 
                 F 
                 F 
                 I 
                 F 
                 F 
                 OCH 3   
                 H 
                 H 
               
               
                 I.a.1296 
                 F 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1297 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1298 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1299 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1300 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1301 
                 F 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1302 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1303 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1304 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1305 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1306 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1307 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1308 
                 F 
                 H 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1309 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1310 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1311 
                 F 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1312 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1313 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1314 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1315 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1316 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1317 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1318 
                 F 
                 F 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1319 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1320 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1321 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1322 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1323 
                 F 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1324 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1325 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1326 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1327 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1328 
                 H 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1329 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1330 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1331 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1332 
                 F 
                 F 
                 I 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 H 
               
               
                 I.a.1333 
                 F 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1334 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1335 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1336 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1337 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1338 
                 F 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1339 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1340 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1341 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1342 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1343 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1344 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1345 
                 F 
                 H 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1346 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1347 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1348 
                 F 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1349 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1350 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1351 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1352 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1353 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1354 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1355 
                 F 
                 F 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1356 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1357 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1358 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1359 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1360 
                 F 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1361 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1362 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1363 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1364 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1365 
                 H 
                 F 
                 F 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1366 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1367 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1368 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
               
                 I.a.1369 
                 F 
                 F 
                 I 
                 F 
                 F 
                 OCH 3   
                 CH 3   
                 CH 3   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 I.a.1370 
                 F 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1371 
                 Cl 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1372 
                 Br 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1373 
                 CN 
                 H 
                 H 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1374 
                 CH 3   
                 H 
                 H 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1375 
                 F 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1376 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1377 
                 F 
                 H 
                 H 
                 Cl 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1378 
                 Cl 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1379 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1380 
                 F 
                 H 
                 H 
                 CN 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1381 
                 CN 
                 H 
                 H 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1382 
                 F 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1383 
                 Cl 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1384 
                 CN 
                 H 
                 F 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1385 
                 F 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1386 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1387 
                 F 
                 Cl 
                 F 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1388 
                 Cl 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1389 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1390 
                 F 
                 CN 
                 F 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1391 
                 CN 
                 F 
                 F 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1392 
                 F 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1393 
                 Cl 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1394 
                 F 
                 Cl 
                 H 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1395 
                 CN 
                 F 
                 H 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1396 
                 F 
                 CN 
                 H 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1397 
                 F 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1398 
                 Cl 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1399 
                 F 
                 Cl 
                 F 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1400 
                 CN 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1401 
                 F 
                 CN 
                 F 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1402 
                 H 
                 F 
                 F 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1403 
                 F 
                 F 
                 Br 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1404 
                 F 
                 F 
                 C≡CH 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1405 
                 CF 3   
                 Cl 
                 H 
                 H 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                 I.a.1406 
                 F 
                 F 
                 I 
                 F 
                 F 
                 H 
                 —O(CH 2 ) 3 — 
               
               
                   
               
            
           
         
       
     
     The herbicidal compounds useful for the present invention may further be used in conjunction with additional herbicides to which the crop plant is naturally tolerant or to which has been made tolerant by mutagenesis as described SUPRA, or to which it is resistant via expression of one or more additional transgenes as mentioned supra. The herbicides useful for the present invention are often best applied in conjunction with one or more other herbicides to obtain control of a wider variety of undesirable vegetation. When used in conjunction with other herbicides (hereinafter referred to a compound B), the presently claimed compounds can be formulated with the other herbicide or herbicides, tank mixed with the other herbicide or herbicides, or applied sequentially with the other herbicide or herbicides. 
     The further herbicidal compound B (component B) is in particular selected from the herbicides of class b1) to b15):
     b1) lipid biosynthesis inhibitors;   b2) acetolactate synthase inhibitors (ALS inhibitors);   b3) photosynthesis inhibitors;   b4) protoporphyrinogen-IX oxidase inhibitors,   b5) bleacher herbicides;   b6) enolpyruvyl shikimate 3-phosphate synthase inhibitors (EPSP inhibitors);   b7) glutamine synthetase inhibitors;   b8) 7,8-dihydropteroate synthase inhibitors (DHP inhibitors);   b9) mitosis inhibitors;   b10) inhibitors of the synthesis of very long chain fatty acids (VLCFA inhibitors);   b11) cellulose biosynthesis inhibitors;   b12) decoupler herbicides;   b13) auxinic herbicides;   b14) auxin transport inhibitors; and   b15) other herbicides selected from the group consisting of bromobutide, chlorflurenol, chlorflurenol-methyl, cinmethylin, cumyluron, dalapon, dazomet, difenzoquat, difenzoquat-metilsulfate, dimethipin, DSMA, dymron, endothal and its salts, etobenzanid, flamprop, flamprop-isopropyl, flamprop-methyl, flamprop-M-isopropyl, flamprop-M-methyl, flurenol, flurenol-butyl, flurprimidol, fosamine, fosamine-ammonium, indanofan, indaziflam, maleic hydrazide, mefluidide, metam, methiozolin (CAS 403640-27-7), methyl azide, methyl bromide, methyl-dymron, methyl iodide, MSMA, oleic acid, oxaziclomefone, pelargonic acid, pyributicarb, quinoclamine, triaziflam, tridiphane and 6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinol (CAS 499223-49-3) and its salts and esters;
       including their agriculturally acceptable salts or derivatives such as ethers, esters or amides.   
       

     Preference is given to those compositions according to the present invention comprising at least one herbicide B selected from herbicides of class b1, b6, b9, b10 and b11. 
     Examples of herbicides B which can be used in combination with the compounds of formula (I) according to the present invention are: 
     b1) from the group of the lipid biosynthesis inhibitors: 
     ACC-herbicides such as alloxydim, alloxydim-sodium, butroxydim, clethodim, clodinafop, clodinafop-propargyl, cycloxydim, cyhalofop, cyhalofop-butyl, diclofop, diclofop-methyl, fenoxaprop, fenoxaprop-ethyl, fenoxaprop-P, fenoxaprop-P-ethyl, fluazifop, fluazifop-butyl, fluazifop-P, fluazifop-P-butyl, haloxyfop, haloxyfop-methyl, haloxyfop-P, haloxyfop-P-methyl, metamifop, pinoxaden, profoxydim, propaquizafop, quizalofop, quizalofop-ethyl, quizalofop-tefuryl, quizalofop-P, quizalofop-P-ethyl, quizalofop-P-tefuryl, sethoxydim, tepraloxydim, tralkoxydim, 4-(4′-Chloro-4-cyclopropyl-2′-fluoro[1,1′-biphenyl]-3-yl)-5-hydroxy-2,2,6,6-tetramethyl-2H-pyran-3(6H)-one (CAS 1312337-72-6); 4-(2′,4′-Dichloro-4-cyclopropyl[1,1′-biphenyl]-3-yl)-5-hydroxy-2,2,6,6-tetramethyl-2H-pyran-3(6H)-one (CAS 1312337-45-3); 4-(4′-Chloro-4-ethyl-2′-fluoro[1,1′-biphenyl]-3-yl)-5-hydroxy-2,2,6,6-tetramethyl-2H-pyran-3(6H)-one (CAS 1033757-93-5); 4-(2′,4′-Dichloro-4-ethyl[1,1′-biphenyl]-3-yl)-2,2,6,6-tetramethyl-2H-pyran-3,5(4H,6H)-dione (CAS 1312340-84-3); 5-(Acetyloxy)-4-(4′-chloro-4-cyclopropyl-2′-fluoro[1,1′-biphenyl]-3-yl)-3,6-dihydro-2,2,6,6-tetramethyl-2H-pyran-3-one (CAS 1312337-48-6); 5-(Acetyloxy)-4-(2′,4′-dichloro-4-cyclopropyl-[1,1′-biphenyl]-3-yl)-3,6-dihydro-2,2,6,6-tetramethyl-2H-pyran-3-one; 5-(Acetyloxy)-4-(4′-chloro-4-ethyl-2′-fluoro[1,1′-biphenyl]-3-yl)-3,6-dihydro-2,2,6,6-tetramethyl-2H-pyran-3-one (CAS 1312340-82-1); 5-(Acetyloxy)-4-(2′,4′-dichloro-4-ethyl[1,1′-biphenyl]-3-yl)-3,6-dihydro-2,2,6,6-tetramethyl-2H-pyran-3-one (CAS 1033760-55-2); 4-(4′-Chloro-4-cyclopropyl-2′-fluoro[1,1′-biphenyl]-3-yl)-5,6-dihydro-2,2,6,6-tetramethyl-5-oxo-2H-pyran-3-yl carbonic acid methyl ester (CAS 1312337-51-1); 4-(2′,4′-Dichloro-4-cyclopropyl-[1,1′-biphenyl]-3-yl)-5,6-dihydro-2,2,6,6-tetramethyl-5-oxo-2H-pyran-3-yl carbonic acid methyl ester; 4-(4′-Chloro-4-ethyl-2′-fluoro[1,1′-biphenyl]-3-yl)-5,6-dihydro-2,2,6,6-tetramethyl-5-oxo-2H-pyran-3-yl carbonic acid methyl ester (CAS 1312340-83-2); 4-(2′,4′-Dichloro-4-ethyl[1,1′-biphenyl]-3-yl)-5,6-dihydro-2,2,6,6-tetramethyl-5-oxo-2H-pyran-3-yl carbonic acid methyl ester (CAS 1033760-58-5); and non ACC herbicides such as benfuresate, butylate, cycloate, dalapon, dimepiperate, EPTC, esprocarb, ethofumesate, flupropanate, molinate, orbencarb, pebulate, prosulfocarb, TCA, thiobencarb, tiocarbazil, triallate and vernolate; 
     b2) from the group of the ALS inhibitors: 
     sulfonylureas such as amidosulfuron, azimsulfuron, bensulfuron, bensulfuron-methyl, chlorimuron, chlorimuron-ethyl, chlorsulfuron, cinosulfuron, cyclosulfamuron, ethametsulfuron, ethametsulfuron-methyl, ethoxysulfuron, flazasulfuron, flucetosulfuron, flupyrsulfuron, flupyrsulfuron-methyl-sodium, foramsulfuron, halosulfuron, halosulfuron-methyl, imazosulfuron, iodosulfuron, iodosulfuron-methyl-sodium, iofensulfuron, iofensulfuron-sodium, mesosulfuron, metazosulfuron, metsulfuron, metsulfuron-methyl, nicosulfuron, orthosulfamuron, oxasulfuron, primisulfuron, primisulfuron-methyl, propyrisulfuron, prosulfuron, pyrazosulfuron, pyrazosulfuron-ethyl, rimsulfuron, sulfometuron, sulfometuron-methyl, sulfosulfuron, thifensulfuron, thifensulfuron-methyl, triasulfuron, tribenuron, tribenuron-methyl, trifloxysulfuron, triflusulfuron, triflusulfuron-methyl and tritosulfuron, imidazolinones such as imazamethabenz, imazamethabenz-methyl, imazamox, imazapic, imazapyr, imazaquin and imazethapyr, triazolopyrimidine herbicides and sulfonanilides such as cloransulam, cloransulam-methyl, diclosulam, flumetsulam, florasulam, metosulam, penoxsulam, pyrimisulfan and pyroxsulam, pyrimidinylbenzoates such as bispyribac, bispyribac-sodium, pyribenzoxim, pyriftalid, pyriminobac, pyriminobac-methyl, pyrithiobac, pyrithiobac-sodium, 4-[[[2-[(4,6-dimethoxy-2-pyrimidinyl)oxy]phenyl]methyl]amino]-benzoic acid-1-methylethyl ester (CAS 420138-41-6), 4-[[[2-[(4,6-dimethoxy-2-pyrimidinyl)oxy]phenyl]methyl]amino]-benzoic acid propyl ester (CAS 420138-40-5), N-(4-bromophenyl)-2-[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzenemethanamine (CAS 420138-01-8), sulfonylaminocarbonyl-triazolinone herbicides such as flucarbazone, flucarbazone-sodium, propoxycarbazone, propoxycarbazone-sodium, thiencarbazone and thiencarbazone-methyl; and triafamone; 
     among these, a preferred embodiment of the invention relates to those compositions comprising at least one imidazolinone herbicide; 
     b3) from the group of the photosynthesis inhibitors: 
     amicarbazone, inhibitors of the photosystem II, e.g. triazine herbicides, including of chlorotriazine, triazinones, triazindiones, methylthiotriazines and pyridazinones such as ametryn, atrazine, chloridazone, cyanazine, desmetryn, dimethametryn, hexazinone, metribuzin, prometon, prometryn, propazine, simazine, simetryn, terbumeton, terbuthylazin, terbutryn and trietazin, aryl urea such as chlorobromuron, chlorotoluron, chloroxuron, dimefuron, diuron, fluometuron, isoproturon, isouron, linuron, metamitron, methabenzthiazuron, metobenzuron, metoxuron, monolinuron, neburon, siduron, tebuthiuron and thiadiazuron, phenyl carbamates such as desmedipham, karbutilat, phenmedipham, phenmedipham-ethyl, nitrile herbicides such as bromofenoxim, bromoxynil and its salts and esters, ioxynil and its salts and esters, uraciles such as bromacil, lenacil and terbacil, and bentazon and bentazon-sodium, pyridate, pyridafol, pentanochlor and propanil and inhibitors of the photosystem I such as diquat, diquat-dibromide, paraquat, paraquat-dichloride and paraquat-dimetilsulfate. Among these, a preferred embodiment of the invention relates to those compositions comprising at least one aryl urea herbicide. Among these, likewise a preferred embodiment of the invention relates to those compositions comprising at least one triazine herbicide. Among these, likewise a preferred embodiment of the invention relates to those compositions comprising at least one nitrile herbicide; 
     b4) from the group of the protoporphyrinogen-IX oxidase inhibitors: 
     acifluorfen, acifluorfen-sodium, azafenidin, bencarbazone, benzfendizone, bifenox, butafenacil, carfentrazone, carfentrazone-ethyl, chlomethoxyfen, cinidon-ethyl, fluazolate, flufenpyr, flufenpyr-ethyl, flumiclorac, flumiclorac-pentyl, flumioxazin, fluoroglycofen, fluoroglycofen-ethyl, fluthiacet, fluthiacet-methyl, fomesafen, halosafen, lactofen, oxadiargyl, oxadiazon, oxyfluorfen, pentoxazone, profluazol, pyraclonil, pyraflufen, pyraflufen-ethyl, saflufenacil, sulfentrazone, thidiazimin, tiafenacil, ethyl [3-[2-chloro-4-fluoro-5-(1-methyl-6-trifluoromethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)phenoxy]-2-pyridyloxy]acetate (CAS 353292-31-6; S-3100), N-ethyl-3-(2,6-dichloro-4-trifluoromethylphenoxy)-5-methyl-1H-pyrazole-1-carboxamide (CAS 452098-92-9), N-tetrahydrofurfuryl-3-(2,6-dichloro-4-trifluoromethylphenoxy)-5-methyl-1H-pyrazole-1-carboxamide (CAS 915396-43-9), N-ethyl-3-(2-chloro-6-fluoro-4-trifluoromethylphenoxy)-5-methyl-1H-pyrazole-1-carboxamide (CAS 452099-05-7), N-tetrahydrofurfuryl-3-(2-chloro-6-fluoro-4-trifluoromethylphenoxy)-5-methyl-1H-pyrazole-1-carboxamide (CAS 452100-03-7), 3-[7-fluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl]-1,5-dimethyl-6-thioxo-[1,3,5]triazinan-2,4-dione, 1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1,3,5-triazinane-2,4-dione (CAS 1258836-72-4), 2-(2,2,7-Trifluoro-3-oxo-4-prop-2-ynyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-4,5,6,7-tetrahydro-isoindole-1,3-dione, 1-Methyl-6-trifluoromethyl-3-(2,2,7-trifluoro-3-oxo-4-prop-2-ynyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-1H-pyrimidine-2,4-dione, methyl (E)-4-[2-chloro-5-[4-chloro-5-(difluoromethoxy)-1H-methyl-pyrazol-3-yl]-4-fluoro-phenoxy]-3-methoxy-but-2-enoate [CAS 948893-00-3], and 3-[7-Chloro-5-fluoro-2-(trifluoromethyl)-1H-benzimidazol-4-yl]-1-methyl-6-(trifluoromethyl)-1H-pyrimidine-2,4-dione (CAS 212754-02-4); 
     b5) from the group of the bleacher herbicides: 
     PDS inhibitors: beflubutamid, diflufenican, fluridone, flurochloridone, flurtamone, norflurazon, picolinafen, and 4-(3-trifluoromethylphenoxy)-2-(4-trifluoromethylphenyl)-pyrimidine (CAS 180608-33-7), HPPD inhibitors: benzobicyclon, benzofenap, clomazone, fenquintrione, isoxaflutole, mesotrione, pyrasulfotole, pyrazolynate, pyrazoxyfen, sulcotrione, tefuryltrione, tembotrione, topramezone and bicyclopyrone, bleacher, unknown target: aclonifen, amitrole and flumeturon; 
     b6) from the group of the EPSP synthase inhibitors: 
     glyphosate, glyphosate-isopropylammonium, glyposate-potassium and glyphosate-trimesium (sulfosate); 
     b7) from the group of the glutamine synthase inhibitors: 
     bilanaphos (bialaphos), bilanaphos-sodium, glufosinate, glufosinate-P and glufosinate-ammonium; 
     b8) from the group of the DHP synthase inhibitors: 
     asulam; 
     b9) from the group of the mitosis inhibitors: 
     compounds of group K1: dinitroanilines such as benfluralin, butralin, dinitramine, ethalfluralin, fluchloralin, oryzalin, pendimethalin, prodiamine and trifluralin, phosphoramidates such as amiprophos, amiprophos-methyl, and butamiphos, benzoic acid herbicides such as chlorthal, chlorthal-dimethyl, pyridines such as dithiopyr and thiazopyr, benzamides such as propyzamide and tebutam; compounds of group K2: chlorpropham, propham and carbetamide, among these, compounds of group K1, in particular dinitroanilines are preferred; 
     b10) from the group of the VLCFA inhibitors: 
     chloroacetamides such as acetochlor, alachlor, butachlor, dimethachlor, dimethenamid, dimethenamid-P, metazachlor, metolachlor, metolachlor-S, pethoxamid, pretilachlor, propachlor, propisochlor and thenylchlor, oxyacetanilides such as flufenacet and mefenacet, acetanilides such as diphenamid, naproanilide, napropamide and napropamide-M, tetrazolinones such fentrazamide, and other herbicides such as anilofos, cafenstrole, fenoxasulfone, ipfencarbazone, piperophos, pyroxasulfone and isoxazoline compounds of the formulae II.1, II.2, II.3, II.4, II.5, II.6, II.7, II.8 and II.9 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     the isoxazoline compounds of the formula (I)I are known in the art, e.g. from WO 2006/024820, WO 2006/037945, WO 2007/071900 and WO 2007/096576; 
     among the VLCFA inhibitors, preference is given to chloroacetamides and oxyacetamides; 
     b11) from the group of the cellulose biosynthesis inhibitors: 
     chlorthiamid, dichlobenil, flupoxam, isoxaben and 1-Cyclohexyl-5-pentafluorphenyloxy-1 4 -[1,2,4,6]thiatriazin-3-ylamine; 
     b12) from the group of the decoupler herbicides: 
     dinoseb, dinoterb and DNOC and its salts; 
     b13) from the group of the auxinic herbicides: 
     2,4-D and its salts and esters such as clacyfos, 2,4-DB and its salts and esters, aminocyclopyrachlor and its salts and esters, aminopyralid and its salts such as aminopyralid-dimethylammonium, aminopyralid-tris(2-hydroxypropyl)ammonium and its esters, benazolin, benazolin-ethyl, chloramben and its salts and esters, clomeprop, clopyralid and its salts and esters, dicamba and its salts and esters, dichlorprop and its salts and esters, dichlorprop-P and its salts and esters, fluroxypyr, fluroxypyr-butometyl, fluroxypyr-meptyl, halauxifen and its salts and esters (CAS 943832-60-8); MCPA and its salts and esters, MCPA-thioethyl, MCPB and its salts and esters, mecoprop and its salts and esters, mecoprop-P and its salts and esters, picloram and its salts and esters, quinclorac, quinmerac, TBA (2,3,6) and its salts and esters and triclopyr and its salts and esters; 
     b14) from the group of the auxin transport inhibitors: diflufenzopyr, diflufenzopyr-sodium, naptalam and naptalam-sodium; 
     b15) from the group of the other herbicides: bromobutide, chlorflurenol, chlorflurenol-methyl, cinmethylin, cumyluron, cyclopyrimorate (CAS 499223-49-3) and its salts and esters, dalapon, dazomet, difenzoquat, difenzoquat-metilsulfate, dimethipin, DSMA, dymron, endothal and its salts, etobenzanid, flamprop, flamprop-isopropyl, flamprop-methyl, flamprop-M-isopropyl, flamprop-M-methyl, flurenol, flurenol-butyl, flurprimidol, fosamine, fosamine-ammonium, indanofan, indaziflam, maleic hydrazide, mefluidide, metam, methiozolin (CAS 403640-27-7), methyl azide, methyl bromide, methyl-dymron, methyl iodide, MSMA, oleic acid, oxaziclomefone, pelargonic acid, pyributicarb, quinoclamine, triaziflam and tridiphane. 
     Active compounds B and C having a carboxyl group can be employed in the form of the acid, in the form of an agriculturally suitable salt as mentioned above or else in the form of an agriculturally acceptable derivative in the compositions according to the invention. 
     In the case of dicamba, suitable salts include those, where the counterion is an agriculturally acceptable cation. For example, suitable salts of dicamba are dicamba-sodium, dicamba-potassium, dicamba-methylammonium, dicamba-dimethylammonium, dicamba-isopropylammonium, dicamba-diglycolamine, dicamba-olamine, dicamba-diolamine, dicamba-trolamine, dicamba-N,N-bis-(3-aminopropyl)methylamine and dicamba-diethylenetriamine. Examples of a suitable ester are dicamba-methyl and dicamba-butotyl. 
     Suitable salts of 2,4-D are 2,4-D-ammonium, 2,4-D-dimethylammonium, 2,4-D-diethylammonium, 2,4-D-diethanolammonium (2,4-D-diolamine), 2,4-D-triethanol-ammonium, 2,4-D-isopropylammonium, 2,4-D-triisopropanolammonium, 2,4-D-heptylammonium, 2,4-D-dodecylammonium, 2,4-D-tetradecylammonium, 2,4-D-triethylammonium, 2,4-D-tris(2-hydroxypropyl)ammonium, 2,4-D-tris(isopropyl)-ammonium, 2,4-D-trolamine, 2,4-D-lithium, 2,4-D-sodium. Examples of suitable esters of 2,4-D are 2,4-D-butotyl, 2,4-D-2-butoxypropyl, 2,4-D-3-butoxypropyl, 2,4-D-butyl, 2,4-D-ethyl, 2,4-D-ethylhexyl, 2,4-D-isobutyl, 2,4-D-isooctyl, 2,4-D-isopropyl, 2,4-D-meptyl, 2,4-D-methyl, 2,4-D-octyl, 2,4-D-pentyl, 2,4-D-propyl, 2,4-D-tefuryl and clacyfos. 
     Suitable salts of 2,4-DB are for example 2,4-DB-sodium, 2,4-DB-potassium and 2,4-DB-dimethylammonium. Suitable esters of 2,4-DB are for example 2,4-DB-butyl and 2,4-DB-isoctyl. 
     Suitable salts of dichlorprop are for example dichlorprop-sodium, dichlorprop-potassium and dichlorprop-dimethylammonium. Examples of suitable esters of dichlorprop are dichlorprop-butotyl and dichlorprop-isoctyl. 
     Suitable salts and esters of MCPA include MCPA-butotyl, MCPA-butyl, MCPA-dimethylammonium, MCPA-diolamine, MCPA-ethyl, MCPA-thioethyl, MCPA-2-ethylhexyl, MCPA-isobutyl, MCPA-isoctyl, MCPA-isopropyl, MCPA-isopropylammonium, MCPA-methyl, MCPA-olamine, MCPA-potassium, MCPA-sodium and MCPA-trolamine. 
     A suitable salt of MCPB is MCPB sodium. A suitable ester of MCPB is MCPB-ethyl. 
     Suitable salts of clopyralid are clopyralid-potassium, clopyralid-olamine and clopyralid-tris-(2-hydroxypropyl)ammonium. Example of suitable esters of clopyralid is clopyralid-methyl. 
     Examples of a suitable ester of fluroxypyr are fluroxypyr-meptyl and fluroxypyr-2-butoxy-1-methylethyl, wherein fluroxypyr-meptyl is preferred. 
     Suitable salts of picloram are picloram-dimethylammonium, picloram-potassium, picloram-triisopropanolammonium, picloram-triisopropylammonium and picloram-trolamine. A suitable ester of picloram is picloram-isoctyl. 
     A suitable salt of triclopyr is triclopyr-triethylammonium. Suitable esters of triclopyr are for example triclopyr-ethyl and triclopyr-butotyl. 
     Suitable salts and esters of chloramben include chloramben-ammonium, chloramben-diolamine, chloramben-methyl, chloramben-methylammonium and chloramben-sodium. Suitable salts and esters of 2,3,6-TBA include 2,3,6-TBA-dimethylammonium, 2,3,6-TBA-lithium, 2,3,6-TBA-potassium and 2,3,6-TBA-sodium. 
     Suitable salts and esters of aminopyralid include aminopyralid-potassium, aminopyralid-dimethylammonium, and aminopyralid-tris(2-hydroxypropyl)ammonium. 
     Suitable salts of glyphosate are for example glyphosate-ammonium, glyphosate-diammonium, glyphoste-dimethylammonium, glyphosate-isopropylammonium, glyphosate-potassium, glyphosate-sodium, glyphosate-trimesium as well as the ethanolamine and diethanolamine salts, preferably glyphosate-diammonium, glyphosate-isopropylammonium and glyphosate-trimesium (sulfosate). 
     A suitable salt of glufosinate is for example glufosinate-ammonium. 
     A suitable salt of glufosinate-P is for example glufosinate-P-ammonium. 
     Suitable salts and esters of bromoxynil are for example bromoxynil-butyrate, bromoxynil-heptanoate, bromoxynil-octanoate, bromoxynil-potassium and bromoxynil-sodium. 
     Suitable salts and esters of ioxonil are for example ioxonil-octanoate, ioxonil-potassium and ioxonil-sodium. 
     Suitable salts and esters of mecoprop include mecoprop-butotyl, mecoprop-dimethylammonium, mecoprop-diolamine, mecoprop-ethadyl, mecoprop-2-ethylhexyl, mecoprop-isoctyl, mecoprop-methyl, mecoprop-potassium, mecoprop-sodium and mecoprop-trolamine. 
     Suitable salts of mecoprop-P are for example mecoprop-P-butotyl, mecoprop-P-dimethylammonium, mecoprop-P-2-ethylhexyl, mecoprop-P-isobutyl, mecoprop-P-potassium and mecoprop-P-sodium. 
     A suitable salt of diflufenzopyr is for example diflufenzopyr-sodium. 
     A suitable salt of naptalam is for example naptalam-sodium. 
     Suitable salts and esters of aminocyclopyrachlor are for example aminocyclopyrachlor-dimethylammonium, aminocyclopyrachlor-methyl, aminocyclopyrachlor-triisopropanolammonium, aminocyclopyrachlor-sodium and aminocyclopyrachlor-potassium. 
     A suitable salt of quinclorac is for example quinclorac-dimethylammonium. 
     A suitable salt of quinmerac is for example quinclorac-dimethylammonium. 
     A suitable salt of imazamox is for example imazamox-ammonium. 
     Suitable salts of imazapic are for example imazapic-ammonium and imazapic-isopropylammonium. 
     Suitable salts of imazapyr are for example imazapyr-ammonium and imazapyr-isopropylammonium. 
     A suitable salt of imazaquin is for example imazaquin-ammonium. 
     Suitable salts of imazethapyr are for example imazethapyr-ammonium and imazethapyr-isopropylammonium. 
     A suitable salt of topramezone is for example topramezone-sodium. 
     Particularly preferred herbicidal compounds B are the herbicides B as defined above; in particular the herbicides B.1-B.189 listed below in table B: 
     
       
         
           
               
               
             
               
                   
                 TABLE B 
               
               
                   
                   
               
               
                   
                 Herbicide B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 B.1 
                 clethodim 
               
               
                   
                 B.2 
                 clodinafop-propargyl 
               
               
                   
                 B.3 
                 cycloxydim 
               
               
                   
                 B.4 
                 cyhalofop-butyl 
               
               
                   
                 B.5 
                 fenoxaprop-ethyl 
               
               
                   
                 B.6 
                 fenoxaprop-P-ethyl 
               
               
                   
                 B.7 
                 metamifop 
               
               
                   
                 B.8 
                 pinoxaden 
               
               
                   
                 B.9 
                 profoxydim 
               
               
                   
                 B.10 
                 sethoxydim 
               
               
                   
                 B.11 
                 tepraloxydim 
               
               
                   
                 B.12 
                 tralkoxydim 
               
               
                   
                 B.13 
                 esprocarb 
               
               
                   
                 B.14 
                 ethofumesate 
               
               
                   
                 B.15 
                 molinate 
               
               
                   
                 B.16 
                 prosulfocarb 
               
               
                   
                 B.17 
                 thiobencarb 
               
               
                   
                 B.18 
                 triallate 
               
               
                   
                 B.19 
                 bensulfuron-methyl 
               
               
                   
                 B.20 
                 bispyribac-sodium 
               
               
                   
                 B.21 
                 cloransulam-methyl 
               
               
                   
                 B.22 
                 chlorsulfuron 
               
               
                   
                 B.23 
                 clorimuron 
               
               
                   
                 B.24 
                 cyclosulfamuron 
               
               
                   
                 B.25 
                 diclosulam 
               
               
                   
                 B.26 
                 florasulam 
               
               
                   
                 B.27 
                 flumetsulam 
               
               
                   
                 B.28 
                 flupyrsulfuron-methyl- 
               
               
                   
                   
                 sodium 
               
               
                   
                 B.29 
                 foramsulfuron 
               
               
                   
                 B.30 
                 imazamox 
               
               
                   
                 B.31 
                 imazamox-ammonium 
               
               
                   
                 B.32 
                 imazapic 
               
               
                   
                 B.33 
                 imazapic-ammonium 
               
               
                   
                 B.34 
                 imazapic- 
               
               
                   
                   
                 isopropylammonium 
               
               
                   
                 B.35 
                 imazapyr 
               
               
                   
                 B.36 
                 imazapyr-ammonium 
               
               
                   
                 B.37 
                 imazapyr- 
               
               
                   
                   
                 isopropylammonium 
               
               
                   
                 B.38 
                 imazaquin 
               
               
                   
                 B.39 
                 imazaquin-ammonium 
               
               
                   
                 B.40 
                 imazethapyr 
               
               
                   
                 B.41 
                 imazethapyr-ammonium 
               
               
                   
                 B.42 
                 imazethapyr- 
               
               
                   
                   
                 isopropylammonium 
               
               
                   
                 B.43 
                 imazosulfuron 
               
               
                   
                 B.44 
                 iodosulfuron-methyl-sodium 
               
               
                   
                 B.45 
                 iofensulfuron 
               
               
                   
                 B.46 
                 iofensulfuron-sodium 
               
               
                   
                 B.47 
                 mesosulfuron-methyl 
               
               
                   
                 B.48 
                 metazosulfuron 
               
               
                   
                 B.49 
                 metsulfuron-methyl 
               
               
                   
                 B.50 
                 metosulam 
               
               
                   
                 B.51 
                 nicosulfuron 
               
               
                   
                 B.52 
                 penoxsulam 
               
               
                   
                 B.53 
                 propoxycarbazon-sodium 
               
               
                   
                 B.54 
                 pyrazosulfuron-ethyl 
               
               
                   
                 B.55 
                 pyribenzoxim 
               
               
                   
                 B.56 
                 pyriftalid 
               
               
                   
                 B.57 
                 pyroxsulam 
               
               
                   
                 B.58 
                 propyrisulfuron 
               
               
                   
                 B.59 
                 rimsulfuron 
               
               
                   
                 B.60 
                 sulfosulfuron 
               
               
                   
                 B.61 
                 thiencarbazone-methyl 
               
               
                   
                 B.62 
                 thifensulfuron-methyl 
               
               
                   
                 B.63 
                 tribenuron-methyl 
               
               
                   
                 B.64 
                 tritosulfuron 
               
               
                   
                 B.65 
                 triafamone 
               
               
                   
                 B.66 
                 ametryne 
               
               
                   
                 B.67 
                 atrazine 
               
               
                   
                 B.68 
                 bentazon 
               
               
                   
                 B.69 
                 bromoxynil 
               
               
                   
                 B.70 
                 bromoxynil-octanoate 
               
               
                   
                 B.71 
                 bromoxynil-heptanoate 
               
               
                   
                 B.72 
                 bromoxynil-potassium 
               
               
                   
                 B.73 
                 Diuron 
               
               
                   
                 B.74 
                 fluometuron 
               
               
                   
                 B.75 
                 hexazinone 
               
               
                   
                 B.76 
                 isoproturon 
               
               
                   
                 B.77 
                 linuron 
               
               
                   
                 B.78 
                 metamitron 
               
               
                   
                 B.79 
                 metribuzin 
               
               
                   
                 B.80 
                 propanil 
               
               
                   
                 B.81 
                 simazin 
               
               
                   
                 B.82 
                 terbuthylazine 
               
               
                   
                 B.83 
                 terbutryn 
               
               
                   
                 B.84 
                 paraquat-dichloride 
               
               
                   
                 B.85 
                 acifluorfen 
               
               
                   
                 B.86 
                 butafenacil 
               
               
                   
                 B.87 
                 carfentrazone-ethyl 
               
               
                   
                 B.88 
                 flumioxazin 
               
               
                   
                 B.89 
                 fomesafen 
               
               
                   
                 B.90 
                 oxadiargyl 
               
               
                   
                 B.91 
                 oxyfluorfen 
               
               
                   
                 B.92 
                 saflufenacil 
               
               
                   
                 B.93 
                 sulfentrazone 
               
               
                   
                 B.94 
                 ethyl [3-[2-chloro-4-fluoro- 
               
               
                   
                   
                 5-(1-methyl-6- 
               
               
                   
                   
                 trifluoromethyl-2,4-dioxo- 
               
               
                   
                   
                 1,2,3,4-tetrahydropyrimidin- 
               
               
                   
                   
                 3-yl) phenoxy]-2-pyridyl - 
               
               
                   
                   
                 oxy]acetate (CAS 353292- 
               
               
                   
                   
                 31-6) 
               
               
                   
                 B.95 
                 1,5-dimethyl-6-thioxo-3- 
               
               
                   
                   
                 (2,2,7-trifluoro-3-oxo-4- 
               
               
                   
                   
                 (prop-2-ynyl)-3,4-dihydro- 
               
               
                   
                   
                 2H-benzo[b][l,4]oxazin-6- 
               
               
                   
                   
                 yl)-1,3,5-triazinane-2,4-dione 
               
               
                   
                   
                 (CAS 1258836-72-4) 
               
               
                   
                 B.96 
                 benzobicyclon 
               
               
                   
                 B.97 
                 clomazone 
               
               
                   
                 B.98 
                 diflufenican 
               
               
                   
                 B.99 
                 flurochloridone 
               
               
                   
                 B.100 
                 isoxaflutole 
               
               
                   
                 B.101 
                 mesotrione 
               
               
                   
                 B.102 
                 norflurazone 
               
               
                   
                 B.103 
                 picolinafen 
               
               
                   
                 B.104 
                 sulcotrione 
               
               
                   
                 B.105 
                 tefuryltrione 
               
               
                   
                 B.106 
                 tembotrione 
               
               
                   
                 B.107 
                 topramezone 
               
               
                   
                 B.108 
                 topramezone-sodium 
               
               
                   
                 B.109 
                 bicyclopyrone 
               
               
                   
                 B.110 
                 amitrole 
               
               
                   
                 B.111 
                 fluometuron 
               
               
                   
                 B.112 
                 fenquintrione 
               
               
                   
                 B.113 
                 glyphosate 
               
               
                   
                 B.114 
                 glyphosate-ammonium 
               
               
                   
                 B.115 
                 glyphosate- 
               
               
                   
                   
                 dimethylammonium 
               
               
                   
                 B.116 
                 glyphosate- 
               
               
                   
                   
                 isopropylammonium 
               
               
                   
                 B.117 
                 glyphosate-trimesium 
               
               
                   
                   
                 (sulfosate) 
               
               
                   
                 B.118 
                 glyphosate-potassium 
               
               
                   
                 B.119 
                 glufosinate 
               
               
                   
                 B.120 
                 glufosinate-ammonium 
               
               
                   
                 B.121 
                 glufosinate-P 
               
               
                   
                 B.122 
                 glufosinate-P-ammonium 
               
               
                   
                 B.123 
                 pendimethalin 
               
               
                   
                 B.124 
                 trifluralin 
               
               
                   
                 B.125 
                 acetochlor 
               
               
                   
                 B.126 
                 butachlor 
               
               
                   
                 B.127 
                 cafenstrole 
               
               
                   
                 B.128 
                 dimethenamid-P 
               
               
                   
                 B.129 
                 fentrazamide 
               
               
                   
                 B.130 
                 flufenacet 
               
               
                   
                 B.131 
                 mefenacet 
               
               
                   
                 B.132 
                 metazachlor 
               
               
                   
                 B.133 
                 metolachlor 
               
               
                   
                 B.134 
                 S-metolachlor 
               
               
                   
                 B.135 
                 pretilachlor 
               
               
                   
                 B.136 
                 fenoxasulfone 
               
               
                   
                 B.137 
                 isoxaben 
               
               
                   
                 B.138 
                 ipfencarbazone 
               
               
                   
                 B.139 
                 pyroxasulfone 
               
               
                   
                 B.140 
                 2,4-D 
               
               
                   
                 B.141 
                 2,4-D-isobutyl 
               
               
                   
                 B.142 
                 2,4-D-dimethylammonium 
               
               
                   
                 B.143 
                 2,4-D-N,N,N- 
               
               
                   
                   
                 trimethylethanolammonium 
               
               
                   
                 B.144 
                 aminopyralid 
               
               
                   
                 B.145 
                 aminopyralid-methyl 
               
               
                   
                 B.146 
                 aminopyralid-dimethyl- 
               
               
                   
                   
                 ammonium 
               
               
                   
                 B.147 
                 aminopyralid-tris(2- 
               
               
                   
                   
                 hydroxypropyl)ammonium 
               
               
                   
                 B.148 
                 clopyralid 
               
               
                   
                 B.149 
                 clopyralid-methyl 
               
               
                   
                 B.150 
                 clopyralid-olamine 
               
               
                   
                 B.151 
                 dicamba 
               
               
                   
                 B.152 
                 dicamba-butotyl 
               
               
                   
                 B.153 
                 dicamba-diglycolamine 
               
               
                   
                 B.154 
                 dicamba-dimethylammonium 
               
               
                   
                 B.155 
                 dicamba-diolamine 
               
               
                   
                 B.156 
                 dicamba- 
               
               
                   
                   
                 isopropylammonium 
               
               
                   
                 B.157 
                 dicamba-potassium 
               
               
                   
                 B.158 
                 dicamba-sodium 
               
               
                   
                 B.159 
                 dicamba-trolamine 
               
               
                   
                 B.160 
                 dicamba-N,N-bis-(3- 
               
               
                   
                   
                 aminopropyl) methylamine 
               
               
                   
                 B.161 
                 dicamba-diethylenetriamine 
               
               
                   
                 B.162 
                 fluroxypyr 
               
               
                   
                 B.163 
                 fluroxypyr-meptyl 
               
               
                   
                 B.164 
                 MCPA 
               
               
                   
                 B.165 
                 MCPA-2-ethylhexyl 
               
               
                   
                 B.166 
                 MCPA-dimethylammonium 
               
               
                   
                 B.167 
                 quinclorac 
               
               
                   
                 B.168 
                 quinclorac- 
               
               
                   
                   
                 dimethylammonium 
               
               
                   
                 B.169 
                 quinmerac 
               
               
                   
                 B.170 
                 quinmerac- 
               
               
                   
                   
                 dimethylammonium 
               
               
                   
                 B.171 
                 aminocyclopyrachlor 
               
               
                   
                 B.172 
                 aminocyclopyrachlor- 
               
               
                   
                   
                 potassium 
               
               
                   
                 B.173 
                 aminocyclopyrachlor-methyl 
               
               
                   
                 B.174 
                 diflufenzopyr 
               
               
                   
                 B.175 
                 diflufenzopyr-sodium 
               
               
                   
                 B.176 
                 dymron 
               
               
                   
                 B.177 
                 indanofan 
               
               
                   
                 B.178 
                 indaziflam 
               
               
                   
                 B.179 
                 oxaziclomefone 
               
               
                   
                 B.180 
                 triaziflam 
               
               
                   
                 B.181 
                 II.1 
               
               
                   
                 B.182 
                 II.2 
               
               
                   
                 B.183 
                 II.3 
               
               
                   
                 B.184 
                 II.4 
               
               
                   
                 B.185 
                 II.5 
               
               
                   
                 B.186 
                 II.6 
               
               
                   
                 B.187 
                 II.7 
               
               
                   
                 B.188 
                 II.8 
               
               
                   
                 B.189 
                 II.9 
               
               
                   
                   
               
            
           
         
       
     
     Moreover, it may be useful to apply the compounds of formula (I) in combination with safeners and optionally with one or more further heribicides. Safeners are chemical compounds which prevent or reduce damage on useful plants without having a major impact on the herbicidal action of the compounds of the formula (I) towards unwanted plants. They can be applied either before sowings (e.g. on seed treatments, shoots or seedlings) or in the pre-emergence application or post-emergence application of the useful plant. The safeners and the compounds of formula (I) and optionally the herbicides B can be applied simultaneously or in succession. 
     Suitable safeners are e.g. (quinolin-8-oxy)acetic acids, 1-phenyl-5-haloalkyl-1H-1,2,4-triazol-3-carboxylic acids, 1-phenyl-4,5-dihydro-5-alkyl-1H-pyrazol-3,5-dicarboxylic acids, 4,5-dihydro-5,5-diaryl-3-isoxazol carboxylic acids, dichloroacetamides, alpha-oximinophenylacetonitriles, acetophenonoximes, 4,6-dihalo-2-phenylpyrimidines, N-[[4-(aminocarbonyl)phenyl]sulfonyl]-2-benzoic amides, 1,8-naphthalic anhydride, 2-halo-4-(haloalkyl)-5-thiazol carboxylic acids, phosphorthiolates and N-alkyl-O-phenylcarbamates and their agriculturally acceptable salts and their agriculturally acceptable derivatives such amides, esters, and thioesters, provided they have an acid group. 
     Examples of preferred safeners C are benoxacor, cloquintocet, cyometrinil, cyprosulfamide, dichlormid, dicyclonon, dietholate, fenchlorazole, fenclorim, flurazole, fluxofenim, furilazole, isoxadifen, mefenpyr, mephenate, naphthalic anhydride, oxabetrinil, 4-(dichloroacetyl)-1-oxa-4-azaspiro[4.5]decane (MON4660, CAS 71526-07-3), 2,2,5-trimethyl-3-(dichloroacetyl)-1,3-oxazolidine (R-29148, CAS 52836-31-4) and N-(2-Methoxybenzoyl)-4-[(methylaminocarbonyl)amino]benzenesulfonamide (CAS 129531-12-0). 
     Particularly preferred safeners C are the following compounds C.1 to C.17 
     
       
         
           
               
               
               
               
               
             
               
                   
                   
               
             
            
               
                   
                 C.1 
                 benoxacor 
                 C.2 
                 cloquintocet 
               
               
                   
                 C.3 
                 cloquintocet-mexyl 
                 C.4 
                 cyprosulfamide 
               
               
                   
                 C.5 
                 dichlormid 
                 C.6 
                 fenchlorazole 
               
               
                   
                 C.7 
                 fenchlorazole-ethyl 
                 C.8 
                 fenclorim 
               
               
                   
                 C.9 
                 furilazole 
                 C.10 
                 isoxadifen 
               
               
                   
                 C.11 
                 isoxadifen-ethyl 
                 C.12 
                 mefenpyr 
               
               
                   
                 C.13 
                 mefenpyr-diethyl 
                 C.14 
                 naphtalic acid anhydride 
               
               
                   
                 C.15 
                 4-(dichloroacetyl)-1-oxa-4- 
                 C.16 
                 2,2,5-trimethyl-3-(dichloro- 
               
               
                   
                   
                 azaspiro[4.5]decane 
                   
                 acetyl)-l,3-oxazolidine 
               
               
                   
                 C.17 
                 N-(2-Methoxybenzoyl)-4- 
               
               
                   
                   
                 [(methylaminocarbonyl)amino] 
               
               
                   
                   
                 benzenesulfonamide 
               
               
                   
                   
               
            
           
         
       
     
     The active compounds B of groups b1) to b15) and the safener compounds C are known herbicides and safeners, see, for example, The Compendium of Pesticide Common Names (http://www.alanwood.net/pesticides/); Farm Chemicals Handbook 2000 volume 86, Meister Publishing Company, 2000; B. Hock, C. Fedtke, R. R. Schmidt, Herbizide [Herbicides], Georg Thieme Verlag, Stuttgart 1995; W. H. Ahrens, Herbicide Handbook, 7th edition, Weed Science Society of America, 1994; and K. K. Hatzios, Herbicide Handbook, Supplement for the 7th edition, Weed Science Society of America, 1998. 2,2,5-Trimethyl-3-(dichloroacetyl)-1,3-oxazolidine [CAS No. 52836-31-4] is also referred to as R-29148. 4-(Dichloroacetyl)-1-oxa-4-azaspiro[4.5]decane [CAS No. 71526-07-3] is also referred to as AD-67 and MON 4660. 
     The assignment of the active compounds to the respective mechanisms of action is based on current knowledge. If several mechanisms of action apply to one active compound, this substance was only assigned to one mechanism of action. 
     It is generally preferred to use the compounds of the invention in combination with herbicides that are selective for the crop being treated and which complement the spectrum of weeds controlled by these compounds at the application rate employed. It is further generally preferred to apply the compounds of the invention and other complementary herbicides at the same time, either as a combination formulation or as a tank mix. 
     In another embodiment, the present invention refers to a method for identifying a herbicide by using a mutated TriA encoded by a nucleic acid which comprises the nucleotide sequence of SEQ ID NO: 1, or a variant or derivative thereof. 
     Said method comprises the steps of:
     a) generating a transgenic cell or plant comprising a nucleic acid encoding a mutated TriA, wherein the mutated TriA is expressed;   b) applying a herbicide to the transgenic cell or plant of a) and to a control cell or plant of the same variety;   c) determining the growth or the viability of the transgenic cell or plant and the control cell or plant after application of said herbicide, and   d) selecting “herbicides” which confer reduced growth to the control cell or plant as compared to the growth of the transgenic cell or plant.   

     As described above, the present invention teaches compositions and methods for increasing the tolerance of a crop plant or seed as compared to a wild-type variety of the plant or seed. In a preferred embodiment, the tolerance of a crop plant or seed is increased such that the plant or seed can withstand a herbicide application of preferably approximately 1-1000 g ai ha −1 , more preferably 1-200 g ai ha −1 , even more preferably 5-150 g ai ha −1 , and most preferably 10-100 g ai ha −1 . As used herein, to “withstand” a herbicide application means that the plant is either not killed or only moderately injured by such application. It will be understood by the person skilled in the art that the application rates may vary, depending on the environmental conditions such as temperature or humidity, and depending on the chosen kind of herbicide (active ingredient ai). 
     Post-emergent weed control methods useful in various embodiments hereof utilize about &gt;0.3× application rates of herbicides; in some embodiments, this can be about, for example, &gt;0.3×, &gt;0.4×, &gt;0.5×, &gt;0.6×, &gt;0.7×, &gt;0.8×, &gt;0.9×, or &gt;1× of herbicides. In one embodiment, herbicide-tolerant plants of the present invention have tolerance to a post-emergant application of a herbicides at an amount of about 25 to about 200 g ai/ha. In some embodiments, wherein the herbicide-tolerant plant is a dicot (e.g., soy, cotton), the post-emergant application of the herbicides is at an amount of about 50 g ai/ha. In another embodiment, wherein the herbicide-tolerant plant is a monocot (e.g., maize, rice, sorghum), the post-emergant application of the herbicides is at an amount of about 200 g ai/ha. In other embodiments, wherein the herbicide-tolerant plant is a  Brassica  (e.g., canola), the post-emergant application of the herbicides is at an amount of about 25 g ai/ha. In post-emergent weed control methods hereof, in some embodiments, the method can utilize herbicides application rates at about 7 to 10 days post-emergent. In another embodiment, the application rate can exceed Ix herbicides; in some embodiments, the rate can be up to 4× herbicides, though more typically it will be about 2.5× or less, or about 2× or less, or about 1× or less. 
     Furthermore, the present invention provides methods that involve the use of at least one herbicide, optionally in combination with one or more herbicidal compounds B, and, optionally, a safener C, as described in detail supra. 
     In these methods, the herbicide can be applied by any method known in the art including, but not limited to, seed treatment, soil treatment, and foliar treatment. Prior to application, the herbicide can be converted into the customary formulations, for example solutions, emulsions, suspensions, dusts, powders, pastes and granules. The use form depends on the particular intended purpose; in each case, it should ensure a fine and even distribution of the compound according to the invention. 
     By providing plants having increased tolerance to herbicide, a wide variety of formulations can be employed for protecting plants from weeds, so as to enhance plant growth and reduce competition for nutrients. A herbicide can be used by itself for pre-emergence, post-emergence, pre-planting, and at-planting control of weeds in areas surrounding the crop plants described herein, or a herbicide formulation can be used that contains other additives. The herbicide can also be used as a seed treatment. Additives found in a herbicide formulation include other herbicides, detergents, adjuvants, spreading agents, sticking agents, stabilizing agents, or the like. The herbicide formulation can be a wet or dry preparation and can include, but is not limited to, flowable powders, emulsifiable concentrates, and liquid concentrates. 
     The herbicide and herbicide formulations can be applied in accordance with conventional methods, for example, by spraying, irrigation, dusting, or the like. 
     Suitable formulations are described in detail in PCT/EP2009/063387 and PCT/EP2009/063386, which are incorporated herein by reference. 
     As disclosed herein, the TriA nucleic acids of the invention find use in enhancing the herbicide tolerance of plants that comprise in their genomes a gene encoding a herbicide-tolerant wild-type or mutated TriA protein. Such a gene may be an endogenous gene or a transgene, as described above. Additionally, in certain embodiments, the nucleic acids of the present invention can be stacked with any combination of polynucleotide sequences of interest in order to create plants with a desired phenotype. For example, the nucleic acids of the present invention may be stacked with any other polynucleotides encoding polypeptides having pesticidal and/or insecticidal activity, such as, for example, the  Bacillus thuringiensis  toxin proteins (described in U.S. Pat. Nos. 5,366,892; 5,747,450; 5,737,514; 5,723,756; 5,593,881; and Geiser et al (1986) Gene 48: 109), 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), Glyphosate acetyl transferase (GAT), cytochrome P450 monooxygenase, phosphinothricin acetyltransferase (PAT), Acetohydroxyacid synthase (AHAS; EC 4.1.3.18, also known as acetolactate synthase or ALS), hydroxyphenyl pyruvate dioxygenase (HPPD), Phytoene desaturase (PD), Protoporphyrinogen oxidase (PPO) and dicamba degrading enzymes as disclosed in WO 02/068607, or phenoxyaceticacid- and phenoxypropionicacid-derivative degrading enzymes as disclosed in WO 2008141154 or WO 2005107437. The combinations generated can also include multiple copies of any one of the polynucleotides of interest. 
     Consequently, Herbicide-tolerant plants of the invention can be used in conjunction with an herbicide to which they are tolerant. Herbicides can be applied to the plants of the invention using any techniques known to those skilled in the art. Herbicides can be applied at any point in the plant cultivation process. For example, herbicides can be applied pre-planting, at planting, pre-emergence, post-emergence or combinations thereof. Herbicides may be applied to seeds and dried to form a layer on the seeds. 
     In some embodiments, seeds are treated with a safener, followed by a post-emergent application of a herbicides. In one embodiment, the post-emergent application of the herbicides is about 7 to 10 days following planting of safener-treated seeds. In some embodiments, the safener is cloquintocet, dichlormid, fluxofenim, or combinations thereof. 
     Methods of Controlling Weeds or Undesired Vegetation 
     In other aspects, the present invention provides a method for controlling weeds at a locus for growth of a plant or plant part thereof, the method comprising: applying a composition comprising a herbicides to the locus. 
     In some aspects, the present invention provides a method for controlling weeds at a locus for growth of a plant, the method comprising: applying an herbicide composition comprising herbicides to the locus; wherein said locus is: (a) a locus that contains: a plant or a seed capable of producing said plant; or (b) a locus that is to be after said applying is made to contain the plant or the seed; wherein the plant or the seed comprises in at least some of its cells a polynucleotide operably linked to a promoter operable in plant cells, the promoter capable of expressing a mutated TriA polypeptide encoded by the polynucleotide, the expression of the mutated TriA polypeptide conferring to the plant tolerance to herbicides. 
     Herbicide compositions hereof can be applied, e.g., as foliar treatments, soil treatments, seed treatments, or soil drenches. Application can be made, e.g., by spraying, dusting, broadcasting, or any other mode known useful in the art. 
     In one embodiment, herbicides can be used to control the growth of weeds that may be found growing in the vicinity of the herbicide-tolerant plants invention. In embodiments of this type, an herbicide can be applied to a plot in which herbicide-tolerant plants of the invention are growing in vicinity to weeds. An herbicide to which the herbicide-tolerant plant of the invention is tolerant can then be applied to the plot at a concentration sufficient to kill or inhibit the growth of the weed. Concentrations of herbicide sufficient to kill or inhibit the growth of weeds are known in the art and are disclosed above. 
     In other embodiments, the present invention provides a method for controlling weeds in the vicinity of a herbicide-tolerant plant of the invention. The method comprises applying an effective amount of a herbicides to the weeds and to the auxinic herbicide-tolerant plant, wherein the plant has increased tolerance to auxinic herbicide when compared to a wild-type plant. In some embodiments, the herbicide-tolerant plants of the invention are preferably crop plants, including, but not limited to, sunflower, alfalfa,  Brassica  sp., soybean, cotton, safflower, peanut, tobacco, tomato, potato, wheat, rice, maize, sorghum, barley, rye, millet, and sorghum. 
     In other aspects, herbicide(s) (e.g., herbicides) can also be used as a seed treatment. In some embodiments, an effective concentration or an effective amount of herbicide(s), or a composition comprising an effective concentration or an effective amount of herbicide(s) can be applied directly to the seeds prior to or during the sowing of the seeds. Seed Treatment formulations may additionally comprise binders and optionally colorants. 
     Binders can be added to improve the adhesion of the active materials on the seeds after treatment. In one embodiments, suitable binders are block copolymers EO/PO surfactants but also polyvinylalcoholsl, polyvinylpyrrolidones, polyacrylates, polymethacrylates, polybutenes, polyisobutylenes, polystyrene, polyethyleneamines, polyethyleneamides, polyethyleneimines (Lupasol®, Polymin®), polyethers, polyurethans, polyvinylacetate, tylose and copolymers derived from these polymers. Optionally, also colorants can be included in the formulation. Suitable colorants or dyes for seed treatment formulations are Rhodamin B, C.I. Pigment Red 112, C.I. Solvent Red 1, pigment blue 15:4, pigment blue 15:3, pigment blue 15:2, pigment blue 15:1, pigment blue 80, pigment yellow 1, pigment yellow 13, pigment red 112, pigment red 48:2, pigment red 48:1, pigment red 57:1, pigment red 53:1, pigment orange 43, pigment orange 34, pigment orange 5, pigment green 36, pigment green 7, pigment white 6, pigment brown 25, basic violet 10, basic violet 49, acid red 51, acid red 52, acid red 14, acid blue 9, acid yellow 23, basic red 10, basic red 108. 
     The term seed treatment comprises all suitable seed treatment techniques known in the art, such as seed dressing, seed coating, seed dusting, seed soaking, and seed pelleting. In one embodiment, the present invention provides a method of treating soil by the application, in particular into the seed drill: either of a granular formulation containing the herbicides as a composition/formulation (e.g., a granular formulation), with optionally one or more solid or liquid, agriculturally acceptable carriers and/or optionally with one or more agriculturally acceptable surfactants. This method is advantageously employed, for example, in seedbeds of cereals, maize, cotton, and sunflower. 
     The present invention also comprises seeds coated with or containing with a seed treatment formulation comprising herbicides and at least one other herbicide such as, e.g., an AHAS-inhibitor selected from the group consisting of amidosulfuron, azimsulfuron, bensulfuron, chlorimuron, chlorsulfuron, cinosulfuron, cyclosulfamuron, ethametsulfuron, ethoxysulfuron, flazasulfuron, flupyrsulfuron, foramsulfuron, halosulfuron, imazosulfuron, iodosulfuron, mesosulfuron, metsulfuron, nicosulfuron, oxasulfuron, primisulfuron, prosulfuron, pyrazosulfuron, rimsulfuron, sulfometuron, sulfosulfuron, thifensulfuron, triasulfuron, tribenuron, trifloxysulfuron, triflusulfuron, tritosulfuron, imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, cloransulam, diclosulam, florasulam, flumetsulam, metosulam, penoxsulam, bispyribac, pyriminobac, propoxycarbazone, flucarbazone, pyribenzoxim, pyriftalid and pyrithiobac. 
     The term “coated with and/or containing” generally signifies that the active ingredient is for the most part on the surface of the propagation product at the time of application, although a greater or lesser part of the ingredient may penetrate into the propagation product, depending on the method of application. When the said propagation product is (re)planted, it may absorb the active ingredient. 
     In some embodiments, the seed treatment application with herbicides or with a formulation comprising the herbicides is carried out by spraying or dusting the seeds before sowing of the plants and before emergence of the plants. 
     In other embodiments, in the treatment of seeds, the corresponding formulations are applied by treating the seeds with an effective amount of herbicides or a formulation comprising the herbicides. 
     In other aspects, the present invention provides a method for combating undesired vegetation or controlling weeds comprising contacting the seeds of the herbicide-tolerant plants of the present invention before sowing and/or after pregermination with herbicides. The method can further comprise sowing the seeds, for example, in soil in a field or in a potting medium in greenhouse. The method finds particular use in combating undesired vegetation or controlling weeds in the immediate vicinity of the seed. The control of undesired vegetation is understood as the killing of weeds and/or otherwise retarding or inhibiting the normal growth of the weeds. Weeds, in the broadest sense, are understood as meaning all those plants which grow in locations where they are undesired. 
     The weeds of the present invention include, for example, dicotyledonous and monocotyledonous weeds. Dicotyledonous weeds include, but are not limited to, weeds of the genera:  Sinapis, Lepiclium, Galium, Stellaria, Matricaria, Anthemis, Galinsoga, Chenopodium, Urtica, Senecio, Amaranthus, Portulaca, Xanthium, Convolvulus, Ipomoea, Polygonum, Sesbania, Ambrosia, Cirsium, Carduus, Sonchus, Solarium, Rorippa, Rotala, Lindernia, Lamium, Veronica, Abutilon, Emex, Datura, Viola, Galeopsis, Papaver, Centaurea, Trifolium, Ranunculus , and  Taraxacum . Monocotyledonous weeds include, but are not limited to, weeds of the genera:  Echinochloa, Setaria, Panicum, Digitaria, Phleum, Poa, Festuca, Eleusine, Brachiaria, Lolium, Bromus, Avena, Cyperus, Sorghum, Agropyron, Cynodon, Monochoria, Fimbristyslis, Sagittaria, Eleocharis, Scirpus, Paspalum, Ischaemum, Sphenoclea, Dactyloctenium, Agrostis, Alopecurus , and  Apera.    
     In addition, the weeds of the present invention can include, for example, crop plants that are growing in an undesired location. For example, a volunteer maize plant that is in a field that predominantly comprises soybean plants can be considered a weed, if the maize plant is undesired in the field of soybean plants. 
     In other embodiments, in the treatment of seeds, the corresponding formulations are applied by treating the seeds with an effective amount of herbicides or a formulation comprising the herbicides. 
     In still further aspects, treatment of loci, plants, plant parts, or seeds of the present invention comprises application of an agronomically acceptable composition that does not contain an A.I. In one embodiment, the treatment comprises application of an agronomically acceptable composition that does not contain a herbicides A.I. In some embodiments, the treatment comprises application of an agronomically acceptable composition that does not contain a herbicides A.L, wherein the composition comprises one or more of agronomically-acceptable carriers, diluents, excipients, plant growth regulators, and the like. In other embodiments, the treatment comprises application of an agronomically acceptable composition that does not contain a herbicides A.I., wherein the composition comprises an adjuvant. In one embodiment, the adjuvant is a surfactant, a spreader, a sticker, a penetrant, a drift-control agent, a crop oil, an emulsifier, a compatibility agent, or combinations thereof. 
     It should also be understood that the foregoing relates to preferred embodiments of the present invention and that numerous changes may be made therein without departing from the scope of the invention. The invention is further illustrated by the following examples, which are not to be construed in any way as imposing limitations upon the scope thereof. On the contrary, it is to be clearly understood that resort may be had to various other embodiments, modifications, and equivalents thereof, which, after reading the description herein, may suggest themselves to those skilled in the art without departing from the spirit of the present invention and/or the scope of the appended claims. 
     EXAMPLES 
     EXAMPLE 1: Bacterial strains. Chemical competent  Escherichia coli  TOP10 (Life Technologies; US) and BL21(DE3) Gold (Agilent Technologies; Germany) was used a recipient in transformation experiments. Transformation was done as described by Maniatis et al. Molecular Cloning: A Laboratory Manual, Cold Spring Habor Laboratory Press, Cold Spring Habor; N.Y. (1982).  Agrobacterium tumefaciens  was used to introduce the T-DNA region into  Arabidopsis , corn and soybean. 
     Bacterial cultures were routinely grown on Luria broth (LB) or at 37° C. on LB mixed with agar (15% w/v). LB was also supplemented with antibiotic kanamycin and/or chloramphenicol where required. Plasmid DNA was prepared using GeneJet Plasmid Miniprep kit (Thermo Scientific, US). TriA and variants of thereof were generated by gene synthesis (Eurofins, Germany). Synthesized genes harboring XhoI and NcoI restriction sites were cloned into pET24d N-HIS vector with kanamycin resistance. Chaperone plasmid pGro7 (chaperones groEL and groES) with chloramphenicol resistance was obtained from TaKaRa (Japan). 
     EXAMPLE 2: Gene synthesis, restriction digestion and cloning. Gene synthesis an appropriate cloning into the pMK-RQ vector was done by Eurofins (Germany). Restriction enzymes were purchased from New England Restriction enzymes were used according to manufactures instructions. 
     EXAMPLE 3: Protein Purification. TriA and variants thereof were produced in  E. coli  BL21(DE3) Gold (Agilent Technologies, Germany). Therefore  E. coli  was transformed with appropriate pET24d N-HIS tag expression vector and chaperone plasmid pGro7 (chaperones groEL and groES). Bacterial strains were grown at 30° C. in 100 mL LB for 20 h and protein expression induced with 0.1 mM IPTG at 25° C. for 20hs. Cells were harvested by centrifugation at 3000 rpm at 4° C. for 20 min, resuspended in Bug Buster protein extraction reagent (Novagen, Germany) according to manufactures instructions. Lysates were clarified by centrifugation. Samples of bovine serum albumin (5, 10, and 20 g) were loaded onto each gel analyzed by densitometry to provide an internal standard. Protein determinations were verified using Coomassie protein assay dye, according to manufactures instruction (Thermo Scientific; USA). The HIS-tagged enzymes were purified by metal ion affinity chromatography using Ni-IDA 1000 kit (Macherey-Nagel, Germany) following manufactures instructions. Protein purity was accessed by SDS-PAGE using NuPAGE Novex 4-12% Bis-Tris pre-cast gels (Life Technologies; USA) stained with Coomassie Brilliant Blue (Serva, Germany). Protein concentrations were estimated by measuring absorbance at 280 nm using Lambda Bio+ (Perkin Elmer, USA). 
     EXAMPLE 4: Enzyme kinetics. Resting cell suspension containing triA gene were incubated with various azines, melamine and atrazine and the culture filtrate was analyzed by UPLC-HR-MS. Substrates were obtained either from Sigma-Aldrich or synthesized internally. Synthetic standards and enzyme reaction products were analysed by UPLC-HR-MS (Thermo/Dionex UPLC UltiMate3000 coupled to a QExactive high resolution mass spectrometer). A Waters Acquity HSS T3 column (2.1 mm; 100 mm; 1.8 uM) was used with a mobile phase water/acetonitrile (0.1% formic acid) with a flow rate of 0.6 ul min −1 . Enzymes were used solved 25 mM sodium phosphate buffer (pH 7.2) with substrate concentration in the range of 1 nM to 10 nM at 30° C. Over time, the original azine peak disappeared whereas the formed OH-Metabolite (reaction product) increased. The product was identified by determination of the exact formula and by analysis of the accurate MS-MS fragments. Moreover for some of the formed products authentic standards were co-eluted. Degradation in % was calculated against the cells harboring the empty vector as control. The results are shown in Table 3 
     
       
         
           
               
               
               
             
               
                   
               
               
                   
                   
                 6-cyclopentyl-N4- 
               
               
                   
                   
                 (2,3,4,5,6- 
               
               
                   
                   
                 pentafluorophenyl)- 
               
               
                   
                   
                 1,3,5-triazine-2,4- 
               
               
                 Mutation 
                 Melamine 
                 diamine 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 N70T 
                 0 
                 0 
               
               
                 N70C 
                 0 
                 0 
               
               
                 N70G 
                 0 
                 0 
               
               
                 N70V 
                 0 
                 4 
               
               
                 Q71T 
                 0 
                 0 
               
               
                 Q71V 
                 0 
                 0 
               
               
                 Q71G 
                 19 
                 0 
               
               
                 Q71C 
                 5 
                 0 
               
               
                 N70VQ71V 
                 0 
                 0 
               
               
                 N70VQ71T 
                 0 
                 0 
               
               
                 N70TQ71V 
                 0 
                 3 
               
               
                 M155L 
                 4 
                 0 
               
               
                 D128G 
                 0 
                 0 
               
               
                 D128P 
                 0 
                 0 
               
               
                 D128V 
                 0 
                 2 
               
               
                 N70VM155V 
                 0 
                 0 
               
               
                 N70VD128SM155V 
                 0 
                 0 
               
               
                 N70VD128TM155V 
                 4 
                 1 
               
               
                 F157T 
                 60 
                 0 
               
               
                 N70LQ71LF157A 
                 2 
                 0 
               
               
                 N70IQ71IF157A 
                 0 
                 3 
               
               
                 L88VL92I 
                 8 
                 0 
               
               
                 L88VL92V 
                 0 
                 0 
               
               
                 L88VL92IF157V 
                 5 
                 0 
               
               
                 L88VL92VF157A 
                 0 
                 0 
               
               
                 Q96V 
                 4 
                 0 
               
               
                 Q71L92VM155AF157A 
                 3 
                 1 
               
               
                 N70VQ71L92VM155AF157A 
                 0 
                 1 
               
               
                 N70IQ71L92VM155AF157A 
                 0 
                 1 
               
               
                 N70LQ71ID128IM155V 
                 9 
                 0 
               
               
                 N70LQ71ID128IM155VF157L 
                 3 
                 0 
               
               
                 Q71LV91A 
                 0 
                 0 
               
               
                 Q71LV91AL92V 
                 7 
                 3 
               
               
                 Q71LL88AV91AL92V 
                 0 
                 1 
               
               
                 Q71LL88AV91AL92VF157L 
                 4 
                 1 
               
               
                 L88AF157I 
                 0 
                 0 
               
               
                 L88AF157L 
                 2 
                 0 
               
               
                 V69A 
                 5 
                 0 
               
               
                 V69L 
                 0 
                 0 
               
               
                 V69S 
                 5 
                 3 
               
               
                 L74V 
                 3 
                 0 
               
               
                 L74A 
                 0 
                 1 
               
               
                 N70LQ71IL74A 
                 2 
                 0 
               
               
                 R82L 
                 1 
                 1 
               
               
                 R82M 
                 2 
                 2 
               
               
                 R82G 
                 0 
                 0 
               
               
                 Q96E 
                 0 
                 0 
               
               
                 Q96D 
                 0 
                 4 
               
               
                 Q96A 
                 0 
                 0 
               
               
                 Q96N 
                 2 
                 2 
               
               
                 N126A 
                 2 
                 4 
               
               
                 N126M 
                 3 
                 0 
               
               
                 N126S 
                 2 
                 1 
               
               
                 N126D 
                 0 
                 0 
               
               
                 D128S 
                 0 
                 0 
               
               
                 D128A 
                 3 
                 5 
               
               
                 D128N 
                 0 
                 2 
               
               
                 M155G 
                 4 
                 0 
               
               
                 M155A 
                 0 
                 4 
               
               
                 M155E 
                 0 
                 0 
               
               
                 F157M 
                 17 
                 0 
               
               
                 F157A 
                 19 
                 0 
               
               
                 L88AY167I 
                 2 
                 0 
               
               
                 L84VL88AY167I 
                 7 
                 3 
               
               
                 L84TL88AY167I 
                 9 
                 4 
               
               
                 A216S 
                 45 
                 1 
               
               
                 A216G 
                 64 
                 0 
               
               
                 I217A 
                 100 
                 4 
               
               
                 I217S 
                 100 
                 3 
               
               
                 I217T 
                 100 
                 3 
               
               
                 P219GH249N 
                 2 
                 0 
               
               
                 I217VP219GH249N 
                 8 
                 0 
               
               
                 A220T 
                 6 
                 1 
               
               
                 A220S 
                 0 
                 3 
               
               
                 A220G 
                 0 
                 0 
               
               
                 F157AA220G 
                 0 
                 0 
               
               
                 E246S 
                 0 
                 1 
               
               
                 E246T 
                 0 
                 3 
               
               
                 E246Q 
                 4 
                 0 
               
               
                 E246D 
                 0 
                 5 
               
               
                 S247A 
                 1 
                 0 
               
               
                 S247N 
                 0 
                 2 
               
               
                 S247V 
                 3 
                 2 
               
               
                 S247G 
                 2 
                 2 
               
               
                 S247P 
                 3 
                 0 
               
               
                 D248S 
                 20 
                 3 
               
               
                 D248N 
                 11 
                 4 
               
               
                 D248G 
                 7 
                 0 
               
               
                 H249V 
                 100 
                 0 
               
               
                 H249I 
                 100 
                 1 
               
               
                 H249N 
                 1 
                 0 
               
               
                 D250E 
                 3 
                 2 
               
               
                 D250N 
                 3 
                 1 
               
               
                 E251D 
                 100 
                 35 
               
               
                 D248EE251D 
                 1 
                 2 
               
               
                 Q298C 
                 100 
                 23 
               
               
                 Q298N 
                 5 
                 0 
               
               
                 Q298T 
                 63 
                 0 
               
               
                 Q298S 
                 83 
                 0 
               
               
                 S301A 
                 0 
                 6 
               
               
                 S301T 
                 0 
                 1 
               
               
                 S301V 
                 0 
                 0 
               
               
                 N302E 
                 8 
                 1 
               
               
                 Y304K 
                 2 
                 0 
               
               
                 Δ S129_A130 
                 0 
                 3 
               
               
                 Δ A130_I131 
                 3 
                 0 
               
               
                 Δ A170_S182 
                 0 
                 2 
               
               
                 Δ R174_L180 
                 1 
                 0 
               
               
                 N70S 
                 0 
                 0 
               
               
                 Q71S 
                 43 
                 0 
               
               
                 F157S 
                 10 
                 0 
               
               
                 Q87T 
                 0 
                 0 
               
               
                 Q71NL92A 
                 87 
                 99 
               
               
                 Q71NL88AL92A 
                 40 
                 64 
               
               
                 Q71NL92AY93L 
                 99 
                 100 
               
               
                 Q71NL92AY93F 
                 78 
                 100 
               
               
                 Q71NL92AD128G 
                 0 
                 61 
               
               
                 Q71NL92AD128A 
                 0 
                 98 
               
               
                 Q71NL88AL92AY93L 
                 4 
                 99 
               
               
                 Q71NL88AL92AY93F 
                 5 
                 92 
               
               
                 Q71NL88AL92AY93LI217A 
                 12 
                 99 
               
               
                 Q71NL88AL92AY93FF157L 
                 1 
                 91 
               
               
                 Q71NL88AL92AD128A 
                 0 
                 4 
               
               
                 Q71NL88AL92AD128G 
                 0 
                 31 
               
               
                 Q71NL92AY93FD128A 
                 0 
                 98 
               
               
                 Q71NL92AY93FD128G 
                 0 
                 74 
               
               
                 Q71NL92AY93FD128GQ96T 
                 1 
                 99 
               
               
                 Q71NL92AM155TF157L 
                 44 
                 98 
               
               
                 Q71NL92AM155TF157V 
                 52 
                 99 
               
               
                 Q71NL92AM155VF157L 
                 67 
                 100 
               
               
                 Q71NL92AD328G 
                 0 
                 6 
               
               
                 L92AF89A 
                 100 
                 100 
               
               
                 L92AF89AY93A 
                 63 
                 100 
               
               
                 L92AY93A 
                 1 
                 56 
               
               
                 L92AY93L 
                 100 
                 99 
               
               
                 L92AY93F 
                 100 
                 100 
               
               
                 F89A 
                 100 
                 26 
               
               
                 Y93A 
                 100 
                 66 
               
               
                 Y93V 
                 100 
                 98 
               
               
                 Y93L 
                 100 
                 82 
               
               
                 Y93F 
                 98 
                 33 
               
               
                 I217G 
                 100 
                 9 
               
               
                 I217G 
                 99 
                 16 
               
               
                 M160G 
                 100 
                 29 
               
               
                 D250S 
                 0 
                 16 
               
               
                 D328G 
                 0 
                 19 
               
               
                 D328A 
                 5 
                 95 
               
               
                 F89AL92AY93L 
                 7 
                 99 
               
               
                 F89LL92AY93L 
                 0 
                 35 
               
               
                 Y85LL92AY93V 
                 0 
                 24 
               
               
                 Y85LF89AL92AY93L 
                 0 
                 15 
               
               
                 Y85LL92AY93LD250S 
                 0 
                 36 
               
               
                 Y85LL92AY93LD128AD250S 
                 0 
                 9 
               
               
                 L92AY93LD250S 
                 0 
                 99 
               
               
                 L88AL92AY93L 
                 0 
                 35 
               
               
                 L88AL92AY93V 
                 0 
                 25 
               
               
                 Y85LL88AL92AY93L 
                 0 
                 13 
               
               
                 Y85LL88AL92AY93V 
                 0 
                 13 
               
               
                 Y85LL88AL92AY93LD128G 
                 0 
                 17 
               
               
                 Y85LL88AL92AY93VD128G 
                 0 
                 11 
               
               
                 Y85LL88AL92AY93LQ96TD128G 
                 0 
                 12 
               
               
                 Y85LL88AL92AY93VQ96TD128G 
                 0 
                 14 
               
               
                 Y85LL88AF89AL92AY93LQ96TD128G 
                 0 
                 9 
               
               
                 Y85LL88AF89AL92AY93VQ96TD128G 
                 0 
                 13 
               
               
                 Q71NL92AY93LQ96TD128G 
                 0 
                 85 
               
               
                 L92AY93LQ96TD128G 
                 0 
                 94 
               
               
                 L92AY93V 
                 0 
                 58 
               
               
                 L92AY93I 
                 0 
                 75 
               
               
                 L92AY93VM155TF157L 
                 0 
                 99 
               
               
                 L92AY93LM155TF157L 
                 41 
                 99 
               
               
                 L92AY93LF157L 
                 43 
                 97 
               
               
                 L88AL92AY93LF157L 
                 1 
                 99 
               
               
                 W87FL92AY93LF157L 
                 1 
                 99 
               
               
                 W87HL92AY93LF157L 
                 0 
                 18 
               
               
                 W87AL92AY93LF157L 
                 3 
                 12 
               
               
                 Y85LL88AF89AL92AY93LQ96TD128GM155VF157L 
                 1 
                 13 
               
               
                 Y85LL88AF89AL92AY93VQ96TD128GM155VF157L 
                 6 
                 13 
               
               
                   
               
            
           
         
       
     
     EXAMPLE 5: Directed evolution of amidohydrolase. The azines were docked into the active site of the triA model (based on the TrzN and AtzA crystal structure) by superimposing the molecules onto melamine. On this basis, the residues that form the active site and substrate binding pocket were identified. The main regions responsible for coordination of the active-site metal ion; residues known to be essential for the amidohydrolase activity; residues that form the hydrophobic “base” of the active site or are essential for hydrolase activity interactions with the aromatic ring of the substrate, were not changed. However, amino acids were modified in order to expand the enzyme pocket. The model was used on the one hand to predict amino acids targets away from the active site that may influence the acceptance of triazines in general, on the other hand the model was used to identify space requiring amino acids in the enzyme pocket which could be changed towards smaller amino acids having a similar hydrophobicity to achieve an accommodation of the more bulky azines without altering the enzyme activity. 
     EXAMPLE 6: Generation of herbicide tolerant model plants. Generation of azine-tolerant  Arabidopsis  plants having mutated amidohydrolase sequences. For transformation of  Arabidopsis thaliana , wildtype or amidohydrolase sequences based on SEQ ID NO: 1, encoding SEQ ID NO:2, are cloned with standard cloning techniques as described in Sambrook et al. (Molecular cloning (2001) Cold Spring Harbor Laboratory Press) in a binary vector containing resistance marker gene cassette (AHAS) and mutated amidohydrolase sequence (marked as GOI) in between ubiquitin promoter (PcUbi) and nopaline synthase terminator (NOS) sequence. Binary plasmids are introduced to  Agrobacterium tumefaciens  for plant transformation.  Arabidopsis thaliana  are transformed with mutated amidohydrolase sequences by floral dip method as decribed by McElver and Singh (WO 2008/124495). Transgenic  Arabidopsis  plants are subjected to TaqMan analysis for analysis of the number of integration loci. 
     EXAMPLE 7: Test for herbicide tolerant model plants. For selection of azine resistant  Arabidopsis thaliana  plants, expressing triA and variants thereof, are used. Selected  Arabidopsis thaliana  lines were assayed for improved resistance to azines like 6-cyclopentyl-N4-(2,3,4,5,6-pentafluorophenyl)-1,3,5-triazine-2,4-diamine in 48-well plates. Therefore, T2-seeds are surface sterilized by stirring for 5 min in ethanol+water (70+30 by volume), rinsing one time with ethanol+water (70+30 by volume) and two times with sterile, deionized water. The seeds are resuspended in 0.1% agar dissolved in water (w/v). Four to five seeds per well are plated on solid nutrient medium consisting of half-strength murashige skoog nutrient solution, pH 5.8 (Murashige and Skoog (1962) Physiologia 40 Plantarum 15: 473-497). Compounds are dissolved in dimethylsulfoxid (DMSO) and added to the medium prior to solidification (final DMSO concentration 0.1%). Multi well plates are incubated in a growth chamber at 22° C., 75% relative humidity and 110 μmol Phot*m-2*s-1 with 14:10 h light: dark photoperiod. Growth inhibition is evaluated seven to ten days after seeding in comparison to wild type plants. Tolerance factors are calculated based on IC50 values of growth inhibition of transformed versus non-transformed  Arabidopsis  plants. Additionally, transgenic T2 or T3  Arabidopsis  plants are tested for improved tolerance to cellulose biosynthesis-inhibiting herbicides in greenhouse studies. 
     EXAMPLE 8: Generation and test of herbicide tolerance crops. Binary vectors are generated as described in EXAMPLE 9. Soybean cv Jake are transformed as previously described by Siminszky et al., Phytochem Rev. 5:445-458 (2006). After regeneration, transformants are transplanted to soil in small pots, placed in growth chambers (16 hr day/8 hr night; 25° C. day/23° C. night; 65% relative humidity; 130-150 microE m-2 s-1) and subsequently tested for the presence of the T-DNA via Taqman analysis. After a few weeks, healthy, transgenic positive, single copy events are transplanted to larger pots and allowed to grow in the growth chamber. An optimal shoot for cutting is about 3-4 inches tall, with at least two nodes present. Each cutting is taken from the original transformant (mother plant) and dipped into rooting hormone powder (indole-3-butyric acid, IBA). The cutting is then placed in oasis wedges inside a bio-dome. The mother plant is taken to maturity in the greenhouse and harvested for seed. Wild type cuttings are also taken simultaneously to serve as negative controls. The cuttings are kept in the bio-dome for 5-7 days. 7-10 days after transfer to oasis wedges, the roots are treated via nutrient solution with the herbicide. Typical phytotox symptoms, like club shaped root, are evaluated 3-4 days after treatment. Less or no injury of transgenic plants compared to wildtype plants are interpreted as herbicide tolerance. 
     For the pre-emergence treatment, the culture containers used were plastic flowerpots containing loamy sand with approximately 3.0% of humus as the substrate. The seeds of the test plants were sown separately for each species/event. The used active ingredients, which had been suspended or emulsified in water, were applied directly after sowing by means of finely distributing nozzles. The containers were irrigated gently to promote germination and growth and subsequently covered with transparent plastic hoods until the plants had rooted. This cover caused uniform germination of the test plants, unless this had been impaired by the active ingredients. 
     Results are shown in  FIG.  1    and Table 4 
     
       
         
           
               
               
               
             
               
                 TABLE 4 
               
               
                   
               
               
                 Aminoacid exchange 
                 Event 
                 Tolerancefactor 
               
               
                   
               
             
            
               
                 Q71N_L92A_Y93F_Q96T_D128G 
                 RAHEKH 
                 ++ 
               
               
                 Q71N_L92A_Y93F_Q96T_D128G 
                 RAHEGE 
                 +++ 
               
               
                 Q71N_L92A_Y93F_Q96T_D128G 
                 RAHDYQ 
                 + 
               
               
                 Q71N_L92A_Y93F_Q96T_D128G 
                 RAHDZA 
                 − 
               
               
                 Q71N_L92A_Y93F_Q96T_D128G 
                 RAHDYT 
                 + 
               
               
                 Q71N_L92A_Y93F_Q96T_D128G 
                 RAHDZD 
                 + 
               
               
                 Q71N_L92A_Y93F_Q96T_D128G 
                 RAHDYS 
                 + 
               
               
                 Q71N_L92A_Y93F_Q96T_D128G 
                 RAHEGW 
                 + 
               
               
                 Q71N_L92A_Y93F_Q96T_D128G 
                 RAHEBZ 
                 − 
               
               
                 Q71N_L92A_Y93F_Q96T_D128G 
                 RAHDYV 
                 − 
               
               
                 L92A_Y93L 
                 RAHEGO 
                 ++ 
               
               
                 L92A_Y93L 
                 RAHEEP 
                 + 
               
               
                 L92A_Y93L 
                 RAHEFH 
                 + 
               
               
                 L92A_Y93L 
                 RAHDYF 
                 − 
               
               
                 L92A_Y93L 
                 RAHDYD 
                 − 
               
               
                 L92A_Y93L 
                 RAHEEZ 
                 ++ 
               
               
                 L92A_Y93L 
                 RAHEAB 
                 − 
               
               
                 L92A_Y93L 
                 RAHEBR 
                 + 
               
               
                 L92A_Y93L 
                 RAHEEN 
                 − 
               
               
                 L92A_Y93L 
                 RAHEGN 
                 − 
               
               
                 L92A_Y93F 
                 RAHEJE 
                 ++ 
               
               
                 L92A_Y93F 
                 RAHEFX 
                 + 
               
               
                 L92A_Y93F 
                 RAHEFY 
                 + 
               
               
                 L92A_Y93F 
                 RAHEJZ 
                 − 
               
               
                 L92A_Y93F 
                 RAHEJD 
                 − 
               
               
                 L92A_Y93F 
                 RAHEJC 
                 − 
               
               
                 L92A_Y93F 
                 RAHEBE 
                 − 
               
               
                 L92A_Y93F 
                 RAHEFQ 
                 − 
               
               
                 L92A_Y93F 
                 RAHEFS 
                 ++ 
               
               
                 L92A_Y93F 
                 RAHEJH 
                 + 
               
               
                 Q71N_L92A_Y93L 
                 RAHCUU 
                 + 
               
               
                 Q71N_L92A_Y93L 
                 RAHCUT 
                 − 
               
               
                 Q71N_L92A_Y93L 
                 RAHDZM 
                 − 
               
               
                 Q71N_L92A_Y93L 
                 RAHDRT 
                 − 
               
               
                 Q71N_L92A_Y93L 
                 RAHCUS 
                 − 
               
               
                 Q71N_L92A_Y93L 
                 RAHDRS 
                 − 
               
               
                 Q71N_L92A_Y93L 
                 RAHDRQ 
                 + 
               
               
                 Q71N_L92A_Y93L 
                 RAHCUV 
                 + 
               
               
                 Q71N_L92A_Y93L 
                 RAHDRY 
                 ++ 
               
               
                 Q71N_L92A_Y93L 
                 RAHDXD 
                 + 
               
               
                 L92A_Y93L_M155V_F157L 
                 RAHIEH 
                 +++ 
               
               
                 L92A_Y93L_M155V_F157L 
                 RAHIEO 
                 + 
               
               
                 L92A_Y93L_M155V_F157L 
                 RAHIEQ 
                 − 
               
               
                 L92A_Y93L_M155V_F157L 
                 RAHILU 
                 ++ 
               
               
                 L92A_Y93L_M155V_F157L 
                 RAHIDY 
                 ++ 
               
               
                 L92A_Y93L_M155V_F157L 
                 RAHILT 
                 + 
               
               
                 L92A_Y93L_M155V_F157L 
                 RAHIAT 
                 − 
               
               
                 L92A_Y93L_M155V_F157L 
                 RAHIDW 
                 − 
               
               
                 L92A_Y93L_M155V_F157L 
                 RAHIAV 
                 + 
               
               
                 L92A_Y93L_M155V_F157L 
                 RAHIEN 
                 + 
               
               
                 L92A_Y93L_F157L 
                 RAHJCN 
                 − 
               
               
                 L92A_Y93L_F157L 
                 RAHIMK 
                 − 
               
               
                 L92A_Y93L_F157L 
                 RAHJCJ 
                 − 
               
               
                 L92A_Y93L_F157L 
                 RAHHZW 
                 + 
               
               
                 L92A_Y93L_F157L 
                 RAHJCP 
                 ++ 
               
               
                 L92A_Y93L_F157L 
                 RAHHZU 
                 ++ 
               
               
                 L92A_Y93L_F157L 
                 RAHHZV 
                 + 
               
               
                 L92A_Y93L_F157L 
                 RAHJCT 
                 − 
               
               
                 L92A_Y93L_F157L 
                 RAHIDK 
                 − 
               
               
                 L92A_Y93L_F157L 
                 RAHIDJ 
                 − 
               
               
                   
               
            
           
         
       
     
     Immature corn embryos were transformed according to the procedure outlined in Peng et al. (WO2006/136596). Plants are tested for the presence of the T-DNA by Taqman analysis with the target being the nos terminator which is present in all constructs. Healthy looking plants are sent to the greenhouse for hardening and subsequent spray testing. The plants are individually transplanted into MetroMix 360 soil in 4″ pots. Once in the greenhouse (day/night cycle of 27° C./21° C. with 14 hour day length supported by 600 W high pressure sodium lights), they are allowed to grow for 14 days. Transgenic corn plants are cultivated to T1 seeds for herbicide tolerance testing. 14 days after transfer, the roots are treated via nutrient solution with the herbicide. Typical phytotox symptoms, like club shaped root, are evaluated 3-4 days after treatment. Less or no injury of transgenic plants compared to wildtype plants are interpreted as herbicide tolerance. 
     For the pre-emergence treatment, the culture containers used were plastic flowerpots containing loamy sand with approximately 3.0% of humus as the substrate. The seeds of the test plants were sown separately for each species/event. The used active ingredients, which had been suspended or emulsified in water, were applied directly after sowing by means of finely distributing nozzles. The containers were irrigated gently to promote germination and growth and subsequently covered with transparent plastic hoods until the plants had rooted. This cover caused uniform germination of the test plants, unless this had been impaired by the active ingredients. 
     For post emergence treatment, the test plants are first grown to a height of 3 to 15 cm, depending on the plant habit, and only then treated with the herbicides. For this purpose, the test plants are either sown directly, grown in the same containers or they are first grown separately and transplanted into the test containers a few days prior to treatment. Herbicide injury evaluations are taken at 2 and 3 weeks after treatment. Plant injury is rated on a scale of 0% to 100%, 0% being no injury and 100% being complete death. 100 means no emergence of the plants, or complete destruction of at least the aerial moieties, and 0 means no damage, or normal course of growth. A moderate herbicidal activity is given at values of at least 60, a good herbicidal activity is given at values of at least 70, and a very good herbicidal activity is given at values of at least 85. 
     Results for corn are shown in  FIG.  2    and Table 5 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Phyto 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                 0 g  
                 32 g  
                 64 g  
                 128 g 
                 256 g 
               
               
                   
                   
                 Al/Ha 
                 Al/Ha 
                 Al/Ha 
                 Al/Ha 
                 Al/Ha 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Construct 
                 Event 
                 Root 
                 Shoot 
                 Root 
                 Shoot 
                 Root 
                 Shoot 
                 Root 
                 Shoot 
                 Root 
                 Shoot 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Wildtype 
                 Wildtype 
                 0 
                 0 
                 30 
                 5 
                 50 
                 0 
                 60 
                 15 
                 85 
                 45 
               
               
                 L92A_Y93L_ 
                 RAHLMX 
                 0 
                 0 
                 35 
                 15 
                 35 
                 25 
                 65 
                 15 
                 80 
                 45 
               
               
                 M155T_F157L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 L92A_Y93L_ 
                 RAHLMY 
                 0 
                 0 
                 15 
                 5 
                 45 
                 0 
                 60 
                 5 
                 60 
                 10 
               
               
                 M155T_F157L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 L92A_Y93L_ 
                 RAHLMV 
                 0 
                 5 
                 15 
                 0 
                 50 
                 10 
                 55 
                 5 
                 60 
                 10 
               
               
                 M155T_F157L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 L92A_Y93L_ 
                 RAHLMW 
                 0 
                 0 
                 35 
                 5 
                 45 
                 10 
                 70 
                 20 
                 85 
                 45 
               
               
                 M155T_F157L 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 L92A_Y93L_ 
                 RAHLMU 
                 0 
                 0 
                 30 
                 0 
                 40 
                 5 
                 60 
                 5 
                 55 
                 15 
               
               
                 M155T_F157L 
               
               
                   
               
            
           
         
       
     
     EXAMPLE 9: Binary Vector Construction. Cloning methods e.g. use of restriction endonucleases to cut double stranded DNA at specific sites, agarose gel electrophoreses, purification of DNA fragments, transfer of nucleic acids onto nitrocellulose and nylon membranes, joining of DNA-fragments, transformation of  E. coli  cells and culture of bacteria were performed as described in Sambrook et al. (1989) (Cold Spring Harbor Laboratory Press: ISBN 0-87965-309-6). Polymerase chain reaction was performed using Phusion™ High-Fidelity DNA Polymerase (NEB, Frankfurt, Germany) according to the manufactures instructions. In general, primers used in PCR were designed such, that at least 20 nucleotides of the 3′ end of the primer anneal perfectly with the template to amplify. Restriction sites were added by attaching the corresponding nucleotides of the recognition sites to the 5′ end of the primer. Fusion PCR, for example described by K. Heckman and L. R. Pease, Nature Protocols (2207) 2, 924-932 was used as an alternative method to join two fragments of interest, e.g. a promoter to a gene or a gene to a terminator. Gene Synthesis, as for example described by Czar et al. (Trends in Biotechnology, 2009, 27(2): 63-72), was performed by Life Technologies using their Geneart® service. 
     Genes were assessed for codon usage and the presence of restriction sites that might impede cloning efforts. Where necessary genes were codon optimized using standard protocols for maximum expression in the crop plant (for example see Puigbo et al. 2007 and Gasper et al. 2012) as well as removal of undesired restriction sites. Genes were either synthesized by GeneArt (Regensburg) or PCR-amplified using Phusion™ High-Fidelity DNA Polymerase (NEB, Frankfurt, Germany) according to the manufactures instructions from cDNA. In both cases a NcoI and/or AscI restriction site at the 5′terminus, and a Pac I restriction site at the 3′ terminus were introduced to enable cloning of these genes between functional elements such as promoters and terminators using these restriction sites. Promoter-terminator modules or promoter-intron-terminator modules were created by complete synthesis by GeneArt (Regensburg) or by joining the corresponding expression elements using fusion PCR and cloning the PCR-product into the TOPO-vector pCR2.1 (Invitrogen) according to the manufactures instructions. While joining terminator sequences to promoter sequences or promoter-intron sequences either via synthesis of whole cassettes or using fusion PCR, recognition sequences for the restriction endonucleases were added to either side of the modules, and the recognition sites for the restriction endonucleases NcoI, AscI and PacI were introduced between promoter and terminator or between introns and terminator. To obtain the final expression modules, PCR-amplified genes were cloned between promoter and terminator or intron and terminator via NcoI and/or Pac I restriction sites. 
     Alternatively, gene synthesis, as for example described by Czar et al. (Trends in Biotechnology, 2009, 27(2): 63-72), can be performed by Life Technologies using their Geneart® service. Standard methods like cloning, restriction, molecular analysis, transformation of  E. coli  cells and culture of bacteria can be performed as described in Sambrook et al. (1989) (Cold Spring Harbor Laboratory Press: ISBN 0-87965-309-6). Polymerase chain reaction can be performed using Phusion™ High-Fidelity DNA Polymerase (NEB, Frankfurt, Germany) according to the manufactures instructions. Fusion PCR can be done as described by K. Heckman and L. R. Pease, Nature Protocols (2207) 2, 924-932. In both cases a NcoI and/or AscI restriction site at the 5′terminus, and a PacI restriction site at the 3′ terminus can be introduced to enable cloning of these genes between functional elements. Promoter-terminator modules or promoter-intron-terminator modules were created by complete synthesis by GeneArt (Regensburg) or by joining the corresponding expression elements using fusion PCR and cloning the PCR-product into the TOPO-vector pCR2.1 (Invitrogen) according to the manufactures instructions. While joining terminator sequences to promoter sequences or promoter-intron sequences either via synthesis of whole cassettes or using fusion PCR, recognition sequences for the restriction endonucleases can be added to either side of the modules, and the recognition sites for the restriction endonucleases NcoI, AscI and PacI can be introduced between promoter and terminator or between introns and terminator. To obtain the final expression modules, PCR-amplified genes can be cloned between promoter and terminator or intron and terminator via NcoI and/or Pac I restriction sites. Genes of interest can be codon optimized using standard protocols for maximum expression in the crop plant (for example see Puigbo et al. 2007 and Gasper et al. 2012) as well as removal of undesired restriction sites and synthesized by GeneArt (Regensburg, Germany). 
     REFERENCES 
     
         
         Esser H O, Dupuis G, Ebert E, Marco G J, Vogel C (1975) s-Triazines. In: Kearney P C, Kaufman D J (eds) Herbicides, chemistry, degradation and mode of action. Marcel Dekker, New York, pp 129-208 
         Seffernick J L, McTavish H, Osborne J P, de Souza M L, Sadowsky M J, Wackett L P (2002) Atrazine chlorohydrolase from  Pseudomonas  sp. strain ADP is a metalloenzyme. Biochemistry 41: 14430-14437 
         Wackett et al.; Biodegradation of atrazine and related s-triazine compounds: from enzymes to field studies, Applied Microbiology and Biotechnology; 58 (1), 39-45, 2002 
         de Souza M L, Sadowsky M J, Wackett L P (1996) Atrazine chlorohydrolase from  Pseudomonas  sp strain ADP: Gene sequence, enzyme purification, and protein characterization. Journal of Bacteriology 178: 4894-4900. 
         Sadowski et al.; U.S. Pat. No. 6,369,299, Transgenic plants expressing bacterial atrazine degrading gene AtzA 
         Padgette S. R. et al., Site directed mutagenesis of a conserved region of the 5-Enolpyruvylshikimate-3-phosphate synthase actives-site; J. Biol. Chem., 266, 33, 1991 
         Maniatis et al. Molecular Cloning: A Laboratory Manual, Cold Spring Habor Laboratory Press, Cold Spring Habor; N.Y. (1982) 
         Gasper P., Oliveira J-L., Frommlet J., Santos M. A. S., Moura G. (2012) EuGene: maximizing synthetic gene design for heterologous expression. Bioinformatics 28(20), 2683-2684. 
         Murashige and Skoog 1962 Physiologia 40 Plantarum 15: 473-497, Molecular cloning Cold Spring Harbor Laboratory Press (2001) 
         Komori T., Imayama T., Kato N., Ishida Y., Ueiki J., Komari T. (2007) Current Status of Binary Vectors and Sub-binary Vectors. Plant Physiology 145, 1155-1160. 
         Puigbo P., Guzman E., Romeu A., Garcia-Valve A. (2007) OPTIMIZER: A Web Server for Optimizing the Codon Usage of DNA Sequences. Nucleic Acids Research 35 web server edition. W126-W131. 
         Siminszky B., Plant cytochrome P450-mediated herbicide metabolism, Phytochem Rev. 5:445-458, 2006