Patent Publication Number: US-2023140636-A1

Title: Packaging for individual articles with use indicator insert and assembly of such a packaging with the articles

Description:
TECHNICAL FIELD 
     The invention concerns the field of cardboard packagings intended to accommodate a predetermined number of individual articles, such a packaging comprising a tubular enclosure obtained by folding at least one blank cut from a sheet of cardboard. Such a packaging is provided, on one side, at a longitudinal end, with an upper opening giving access to an inner space in which the individual articles are intended to be received. The invention more particularly relates to packagings for individual single-use articles. In particular, the invention has a particularly advantageous application in the field of packaging of single-use medical products. 
     When a packaging is intended to accommodate a plurality of individual articles, the individual articles are intended to be used, therefore to be withdrawn from the packaging, as they are used. In certain cases, after use of an article, the user may be led to replace the article in the packaging. Often, the packaging also comprises internal wedging which has a certain number of wedging shapes, this number being the predetermined number of individual articles that the packaging is intended to accommodate. Initially, each wedging shape accommodates an individual article. However, it becomes practical for the user, after use of the individual article, to rest the used individual article in the packaging, in particular in the wedging shape from which it was extracted. 
     However, in particular, if single-use individual articles are involved, or sensitive individual articles, it may be necessary, or in any case very useful, to be able to easily identify that an article contained in the packaging has already been withdrawn at least once from the packaging, to show that it has probably already been used. Such an indication enables the user to know instantly whether or not a given article is still unused. 
     It is noted that this indication, or use indicator, is above all for information purposes and is above all intended to inform a user in good faith. This indication is not necessarily a complete guarantee of non-use. 
     The aim of the invention is therefore to provide a packaging comprising means for visualising that a determined article, initially contained in a packaging, has been withdrawn at least a first time from the packaging. 
     DISCLOSURE OF THE INVENTION 
     For this purpose, the invention provides a packaging for packaging a determined number of individual articles, the packaging comprising a packaging case having an enclosure:
         which is obtained by folding at least one blank cut from a sheet of cardboard,   which is tubular in a longitudinal direction,   which has, in a transverse plane perpendicular to the longitudinal direction, a closed polygonal transverse contour around an inner space of the packaging case,   which comprises an upper opening at a upper longitudinal end of the enclosure and a lower closure at a lower longitudinal end of the enclosure.       

     The packaging comprises a use indicator insert:
         which is received in the inner space of the packaging case above a lower portion of the inner space, the lower portion of the inner space being intended to receive the individual articles,   which comprises a transverse plate extending perpendicularly to the longitudinal direction of the enclosure of the packaging case.       

     The transverse plate is obtained from at least one blank cut from a sheet of cardboard. 
     The transverse plate has the same number of individual access openings for an individual article, as the determined number of individual articles. 
     The transverse plate has, around each individual access opening, an individual precut system which at least partially surrounds the associated individual access opening and which comprises at least one or more precut lines, each individual precut system determining, after breaking of the precut line or lines, an individual extraction opening which encompasses the individual access opening and which has at least one transverse extraction dimension which is greater than a corresponding transverse dimension of the corresponding individual access opening. 
     The packaging also comprises anchoring means for ensuring the anchoring of the use indicator insert in the packaging case. 
     Such a packaging can furthermore comprise one or other of the following optional additional features, taken alone or in combination. 
     In certain embodiments, at least one individual precut system completely surrounds the associated individual opening. In certain alternatives of such embodiments, at least one individual precut system comprises a precut line which completely surrounds the associated individual access opening and which delimits, in the transverse plate of the use indicator insert, a ring which, by breaking the precut line, detaches itself from the transverse plate. 
     In certain embodiments, at least one individual precut system only partially surrounds the associated individual access opening and delimits, in the transverse plate of the use indicator insert, at least one leaf which, after breaking of the precut line or lines, remains attached to the transverse plate by a non-precut connection region, while being able to pivot around a fold line which extends transverse to the connection region. In certain alternatives of such embodiments, the fold line which extends transverse to the connection region is a premarked fold line. 
     In certain embodiments, the packaging comprises at least one internal wedging of the individual articles, the internal wedging being obtained from at least one blank cut from a sheet of cardboard, and the internal wedging being received in the inner space of the packaging case, and the anchoring means ensure a connection between the use indicator insert and the internal wedging in order to ensure the anchoring of the use indicator insert in the packaging case. In certain alternatives of such embodiments, the anchoring means comprise at least one anchoring tab, integral with one among the use indicator insert and the internal wedging, and an anchoring slot arranged in the other among the use indicator insert and the internal wedging, and the anchoring tab comprises an anchoring shape enabling the insertion of the anchoring tab into the anchoring slot and opposing the withdrawal of the anchoring tab relative to the anchoring slot. In certain of these alternatives, the anchoring slot is arranged at a fold line between a transverse plate and a flap, the fold line defining a folding axis and the flap being folded over towards the direction from which the anchoring tab must be inserted in the anchoring slot, in that the anchoring slot comprises a central lumen and, on each side of the central lumen in the direction of the folding axis, junction cuts which join the corresponding end of the central lumen at the fold line, and the junction cuts have an offset relative to the folding axis, in a direction of the flap, in order to define transverse projections of the transverse plate which prolong the transverse plate beyond the folding axis. 
     In certain embodiments comprising an internal wedging, the internal wedging is produced in a single piece with the blank from which the enclosure is obtained. 
     In certain embodiments comprising an internal wedging, the internal wedging has a number of wedging shapes corresponding to the determined number of individual articles. 
     In certain embodiments, the packaging comprises a lower internal wedging and an upper internal wedging arranged above the lower internal wedging in the inner space delimited by the case, and the anchoring means ensure a connection between the use indicator insert and the upper internal wedging in order to ensure the anchoring of the use indicator insert in the packaging case. 
     In certain embodiments comprising an internal wedging, the internal wedging determines a position and an orientation of each individual article with regard to an individual access opening associated with this individual article. 
     In certain embodiments, the use indicator insert is arranged in the packaging at a predetermined distance from the upper longitudinal end of the enclosure, towards the interior in the longitudinal direction. 
     In certain embodiments, the packaging case and the opening indicator insert are each obtained from separate cardboard blanks. By contrast, in certain embodiments, the packaging case and the opening indicator insert are each obtained from a common cardboard blank. 
     The invention further concerns an assembly comprising, on the one hand, a packaging as described above and, on the other hand, individual articles contained in the packaging, characterised in that the individual articles have at least one portion which is received in the lower portion of the inner space of the packaging case, said portion having a transverse dimension which is greater than a corresponding transverse dimension of the individual access opening associated with this article. 
     In certain embodiments of such an assembly, the transverse dimensions of each individual article are less than the transverse dimensions of the corresponding individual extraction openings. 
     In certain embodiments of such an assembly, the individual articles comprise an upper portion which projects above the use indicator insert. 
    
    
     
       BRIEF DESCRIPTION OF THE FIGURES 
         FIG.  1    is a perspective schematic view with a cutaway, showing a packaging according to the invention, in which a first individual article that has never been withdrawn from the packaging and a second individual article that has already been withdrawn from the packaging are shown. 
         FIG.  2    is a plan view of an exemplary embodiment of a blank for producing a packaging case according to an embodiment of the invention. 
         FIG.  3    is a plan view of an exemplary embodiment of a blank for producing a first exemplary embodiment of an opening indicator insert for a packaging according to the invention. 
         FIG.  4    is a plan view of an exemplary embodiment of a blank for providing a second exemplary embodiment of an opening indicator insert for a packaging according to the invention. 
         FIG.  5    is a perspective schematic view with a cutaway, showing a packaging according to the invention. 
         FIG.  6    is a perspective schematic view with a cutaway along a plane perpendicular to the cutaway plane of  FIG.  5   , showing the packaging of  FIG.  5   . 
         FIG.  7    is a perspective schematic view of an exemplary embodiment of the blank of  FIG.  4   , for providing a second exemplary embodiment of an opening indicator insert. 
         FIG.  8    is a schematic plan view of a detail of an exemplary embodiment of a blank for producing a packaging case having an improved anchoring slot. 
         FIG.  9    is a schematic side view showing anchoring means comprising an anchoring tab and an anchoring slot, the latter being produced from a blank as illustrated in  FIG.  8   . 
     
    
    
     DESCRIPTION OF CERTAIN EMBODIMENTS 
     The invention relates to a packaging  10  for packaging a determined number of individual articles  12 . In the example, each individual article is a syringe  12  comprising a syringe body  14  and a piston  16  which delimits, in the syringe body, a volume filled with a fluid product, in particular a liquid product. In known manner, the syringe body  14  has, at an upper end, a collar  18  enabling the user to counterbalance a pushing force exerted on the piston  16 . However, the invention also relates to packagings for other types of individual articles, for example individual flasks, individual tools etc. In many cases, an individual article  12  will be a single-use article. The invention will have particular application in fields requiring that the individual articles have properties of integrity before use, in particular non-contamination properties. 
     The packaging  10  is intended to contain a determined number, greater than or equal to two, of individual articles  12  that will generally be identical to one another. It is noted, however, that the invention can be implemented for packagings intended to contain several series of individual articles, the individual articles of one series being identical with one another, but the individual articles of two different series optionally being different. In the example, the individual articles of a first series could for example, be syringes, whereas the individual articles of a second series could be the needles intended to be used with these syringes. In the illustrative example, the packaging  10  is provided for a single series of identical individual articles, here for example a number equal to 10 syringes. 
     The packaging  10  shown in the figures comprises firstly, and mainly, a packaging case  20  having an enclosure  22  which is obtained by folding at least one blank  24  cut from a sheet of cardboard, an example of which is illustrated in  FIG.  2   . The enclosure  22  is tubular in a longitudinal direction. In the rest of the text, it is considered that, on using the packaging  10 , the longitudinal direction corresponds to the vertical direction of terrestrial gravity, while the transverse directions will be the horizontal directions. In the sense of the present text, it is noted that the longitudinal direction is not necessarily the direction along which the packaging has the largest dimension. As will be understood, the longitudinal direction is that which is perpendicular to an opening of the packaging via which the individual articles are intended to be withdrawn. 
     In the example, the packaging  10  consists exclusively of cardboard and is formed exclusively from one or more blanks cut from a sheet of cardboard. In the example, the packaging  10  consists of two separate blanks, one, an exemplary embodiment of which is illustrated in  FIG.  2   , is intended to form a case, here comprising, by way of example, wedging means, and the other, two exemplary embodiments of which are respectively illustrated in  FIGS.  3  and  4   , is intended to form an opening indicator insert  70 . 
     Preferably, the cardboard used for the packaging  10  is a compact cardboard, also called flat cardboard, as opposed to corrugated cardboard. A sheet of compact cardboard thus has a front face and a reverse face, and, in its thickness between the front face and the reverse face, this material has a substantially constant density, as opposed to a corrugated cardboard which comprises empty spaces between its front face and its rear face. However, the packaging according to the invention can also be produced, at least partially, in corrugated cardboard. 
     Typically, the packaging  10  can be produced in compact cardboard having a grammage in the range from 160 grams per square metre to 600 grams per square metre, preferably in the range from 180 grams per square metre to 400 grams per square metre. 
     The enclosure  22  has, seen in section through a transverse plane perpendicular to the longitudinal direction, a closed polygonal transverse contour around an inner space of the packaging  20 . 
     In the illustrative example, the tubular enclosure  22  comprises at least four main successive panels  26 . i  (in the illustrated example:  26 . 1 ,  26 . 2 ,  26 . 3 ,  26 . 4 ) traversing the closed polygonal transverse contour. In this example, two main successive panels  26   i  traversing the closed transverse contour are connected at a common longitudinal edge, the common longitudinal edge corresponding to a fold line of the sheet of cardboard. In the illustrated example of a flat blank  24 , which is delimited by an outer contour along which it has been cut from a sheet of cardboard, the four successive main panels  26   i  are juxtaposed with one another in a transverse direction. 
     The number of main panels of the tubular enclosure  22  is equal to the number of sides of the transverse polygonal contour of the tubular enclosure  22 . In the illustrated example, the number of main panels of the tubular enclosure is equal to four. The transverse polygonal contour of the tubular enclosure is therefore a quadrilateral, preferably a rectangle or a square. However, the number of main panels of the tubular enclosure  22  could be greater than four. 
     In the plan views of the blanks, the free or cut edges of the blank, in particular of the outer contour, have been shown as thick continuous lines. Predefined fold lines, marked in the material of the blank, to the extent where the blank is not cut or in any case not entirely cut, have been shown as mixed lines. The producing of fold lines may involve one or more techniques, including, for example:
         the kiss-cutting technique, in which the sheet of material is cut, but not through its full thickness;   marking by crushing material (creasing), etc.       

     These predefined fold lines of the sheet of cardboard, also called premarked fold lines, facilitate the three-dimensional assembly, but are not intended to be broken during normal use of the packaging. 
     Also illustrated in the plan views of the blanks, with dashes, are precut lines which are intended to allow tearing of the material along the thus produced precut line. 
     A precut line is a line along which the material is partially, but not entirely, cut, so as to keep a connection between the two sides of the precut line, this connection however being weakened relative to the strength of the material. Such a precut line can be produced in the form of a kiss-cut, over all or part of the length of the precut line, but is preferably produced in the form of a discontinuous cut along the line, with alternating entirely cut sections and uncut or kiss-cut sections. 
     The blank  24  of the case  20  therefore comprises, in the illustrated example, four main panels  26 . i  which are juxtaposed and articulated successively one after the other about three parallel longitudinal fold lines  28 . i  (in this case  28 . 1 ,  28 . 2 ,  28 . 3 ). A first fold line  28 . 1  connects and delimits an end distal main panel, which will here be arbitrarily qualified as the rear main panel  26 . 1 , and an intermediate distal main panel, which will here be arbitrarily qualified as the first side panel  26 . 2 . A second fold line  28 . 2  connects the first side panel  26 . 2  to an intermediate proximal main panel, which will here be arbitrarily qualified as the front main panel  26 . 3 , and which is connected along a fold line  28 . 3  to an end proximal main panel, which will here be arbitrarily qualified as the second side panel  26 . 4 . The fold lines  28 . i  therefore define, in the flat blank  20 , longitudinal sides of the corresponding main panels. 
     The rear main panel  26 . 1  further comprises a longitudinal side  30  via which it is connected to an assembly flap  32 , the longitudinal side  30  corresponding to a fold line between the rear main panel  26 . i  and the assembly flap  32 . Transversely opposite the longitudinal side  30 , the assembly flap  32  comprises a longitudinal free edge  34 , which is a free edge of the blank  24 , belonging to the outer contour of the blank  24 . 
     The second side panel  26 . 4  comprises, transversely opposite the longitudinal side  28 . 3 , a longitudinal side  36  which, in this exemplary embodiment, is a free edge of the blank  24 , belonging to the outer contour of the blank  24 . 
     Each of the main panels  26 . i  has opposite upper  38 . i  (in this case  38 . 1 ,  38 . 2 ,  38 . 3 ,  38 . 4 ) and lower  40 . i  (in this case  40 . 1 ,  40 . 2 ,  40 . 3 ,  40 . 4 ) transverse sides, which are arranged at the longitudinal ends of the corresponding panel. In the text, “upper” designates, in an arbitrary but usual manner, the longitudinal side of the packaging via which it will be opened on use. The concepts of “high”, “low”, “above”, “below”, etc. used in this text arise from this concept of “upper”. 
     In the proposed example, the main panels all have the same size in the longitudinal direction so that, in the fiat blank  24 , the upper  38 . i  and lower  40 . i  transverse edges of the four main panels  26 . i  are respectively aligned along an upper transverse line and along a lower transverse line. 
     It is understood that the four main panels  26 . i  are intended to form, after folding through 90° around each of the fold lines  28 . 1 , which each therefore become a common longitudinal edge between two successive main panels, a tubular enclosure  22 , closed on itself, in which the main panels  26 . i  define the closed polygonal contour around an inner space of the case  20 . It is also understood that the assembly flap  32  can itself also be folded through 90° around the fold line  30  in such a way as to be able to be brought into abutment, plane against plane, against the second side panel  26 A. Assembly of the assembly flap  32  on the second side panel  26 . 4 , for example by gluing, makes it possible to fix the three-dimensional geometry of the packaging case  20 . The fact that the enclosure  22  defines a closed contour does not preclude the main panels, which compose it, from possibly having windows or openings. 
     Furthermore, the packaging case  20  comprises an opening  50  via which it is intended that the user accesses the individual articles  12  contained in the packaging case  20 , and through which the individual articles  12  can be extracted. By convention in this text, this opening is qualified as the upper opening  50  and it is therefore arranged at an upper longitudinal end of the tubular enclosure  22 . 
     The way in which the illustrated blank  24  illustrated and described in detail above is produced, and in particular the arrangement of the main panels relative to the longitudinal direction, is only one exemplary embodiment. Thus, it could be provided that the blank comprises juxtaposed panels in the longitudinal direction which has already been seen, and that is explained further below, that is defined by the position of the opening via which it is envisaged that the user accesses the articles. These panels juxtaposed in the plane could thus comprise, for example, in such a case, an upper panel (forming the upper opening or comprising an arrangement forming the upper opening), a lower panel, and two side or front and rear panels. 
     The packaging case  20  comprises a lower closure  60  at a lower longitudinal end of the tubular enclosure  22 , thus on the side opposite the side of the packaging case  20  where the upper opening  50  is arranged. 
     In the example, the lower closure  60  of the packaging case  12  comprises as many lower flaps  62 . i  as the number of main panels  26 . i , i.e., in the illustrated example, four lower flaps  62 . 1 ,  62 . 2 ,  62 . 3 ,  62 . 4 . In this example, each lower flap  62 . i  is connected to a lower transverse edge  40 . i  of one of the main panels  26 . i  of the tubular enclosure  22 . During the assembly of the packaging case  20 , the lower flaps  62 . 1  are folded over transversely, at right angles relative to the longitudinal direction, towards the inside of the space delimited by the tubular enclosure  22 . The lower flaps  62 . 1  are folded over with overlap and are assembled together in order to ensure locking of the lower closure  60  of the packaging case  12 , either by shape matching or by bonding. The lower closure  60  of the packaging case  20  could be produced in the form of an automatic bottom which deploys automatically during the assembly of the packaging case  10 . A person skilled in the art knows numerous ways to produce an automatic bottom with glued flaps. 
     As can be seen in the figures, the upper opening  50  of the packaging case  12  comprises, in the illustrated example, an upper closure leaf  52  which has a contour identical to the closed transverse contour of the tubular enclosure  22 . This upper closure leaf  52  is articulated by an attachment edge on a transverse edge of one of the main panels of the tubular enclosure. In the illustrated example, the upper closure leaf  52  is connected to the rear main panel  26 . 1  at the upper transverse edge  38 . 1  thereof, which therefore also forms the attachment edge of the upper closure leaf  52 . Preferably, in the blank  10 , the upper transverse edge  38 . 1  of the rear panel  26 . 1  is therefore in the form of a fold line. Thus, in this example, the upper opening of the packaging, via which a user can extract the individual articles, is formed by opening the upper closure leaf  52 , by pivoting it around its attachment edge  38 . 1 . 
     In other designs of the packaging case  20 , the upper opening  50  of the packaging could be arranged in an upper panel of the packaging, for example in the form of a precut line in this panel of the case (this panel being, according to the terminology adopted in this text, an upper panel of the case) so as to delimit in this upper panel for example, an access leaf or hatch to the inner space. 
     The upper closure leaf  52  comprises an insertion tab  54  which is articulated at a free edge  56  of the upper closure leaf  52 , this free edge  56  being opposite the attachment edge  38 . 1  of the upper closure leaf  52 . During the assembly of the packaging case  20 , the insertion tab  54  can be folded by 90° around the free edge  56 , and the upper closure leaf  52  can be folded over by 90° in order to adopt a horizontal transverse orientation in which the insertion tab  54  is inserted into the inner space delimited by the tubular enclosure  22 . In the example, the insertion tab  54  is thus, in the closure configuration of the upper closure leaf  52 , engaged in the inner space opposite the inner face of the front main panel  26 . 3 . 
     However, it is particularly advantageous that the tubular enclosure  22  comprises, at an upper transverse edge of one of the main panels, a locking tab  58  of the upper closure leaf  52 . Preferably, this locking tab  58  is arranged at an upper transverse edge of one of the main panels which is opposite that of the main panels to which the upper closure leaf  52  is attached. In this case, in the illustrated example, the locking tab  58  is thus advantageously arranged at the upper transverse edge  38 . 3  of the front main panel  26 . 3  of the tubular enclosure  22 . The locking tab  58  has a projection which, when the upper closure leaf  52  is in the closure configuration, is intended to be engaged in a slot  59  arranged at the centre of the free edge  56  of the upper closure leaf  52 , between the upper closure leaf  52  and the insertion tab  54 . 
     Advantageously, the locking tab  58  can be configured to form a tamper indicator, for example by having the shape of a harpoon. Hence, after a first closure operation of the upper closure  50  of the packaging case  10 , the upper closure leaf  52  can be locked in the closure configuration using the locking tab  58 , and any attempt at opening will be visible, for example due to the alteration or even a tearing of the locking tab  58 . The locking tab  58  can advantageously comprise a line of weakness, for example a precut line, which will be arranged, for example, at the base of the harpoon shape, which will tend to tear easily in the event of an attempt to withdraw the locking tab. Alteration of the locking tab makes the opening of the packaging case  20  immediately visible. On the other hand, if the tamper indicator formed by the locking tab  58  appears intact, this reinforces the confidence of the user in the integrity of the packaging  10  and therefore of its contents. 
     According to the invention the packaging comprises a use indicator insert  70  for visualising that an individual article  12 , initially contained in the packaging, has been extracted therefrom. 
     In the illustrated embodiments, the use indicator insert  70  is received in the inner space of the packaging, above a lower portion  72  of the inner space, the lower portion  72  of the inner space being intended to receive the individual articles  12 . 
     The use indicator insert  70  comprises a transverse plate  74  which extends perpendicularly to the longitudinal direction of the enclosure of the packaging case. Preferably, the use indicator insert  70  extends over the entire surface of the transverse section of the enclosure  22  such that an individual article cannot be extracted from the lower portion  72  of the inner space of the packaging when the use indicator insert  70  is in place, at least, as will be explained, cannot be extracted without the use indicator insert  70  being clearly and visibly marked by this extraction. 
     Advantageously, the transverse plate  74  of the use indicator insert  70  is obtained from at least one blank cut in a sheet of cardboard, such as the packaging case  20 . In the examples illustrated, the entirety of the use indicator insert  70  is obtained from a single blank. In the examples illustrated, the transverse plate  74  of the use indicator insert  70  is obtained from a blank which is distinct from the blank  24  forming the packaging case  20 . However, in certain embodiments, the use indicator insert  70  can also be obtained from the same blank as the packaging case  20 . 
     According to one aspect, the transverse plate  74  of the use indicator insert  70  has the same number of individual access openings  76  to an individual article, as the determined number of individual articles. Each individual access opening  76  has at least one transverse dimension which is less than a transverse dimension of the associated individual article  12 . In other words, each individual access opening  76  has a geometry and dimensions which prevent the individual article  12  from being extracted from the packaging  10  through the individual access opening  76  without the use indicator insert  70  being clearly and visibly marked by this extraction. In the illustrated example, the individual access openings  76  are circular openings. These individual access openings  76  are adapted to the individual articles  12  of the example, which are therefore syringes, the syringes having, at their collar  18 , a transverse dimension greater than the diameter of the individual access openings  76 . 
     In other words, in general, the individual articles  12  have at least one portion  18  which is received in the lower portion  72  of the inner space of the packaging case  20 , and which has a transverse dimension greater than a corresponding transverse dimension of the individual access opening associated with this article. 
     On the other hand, the transverse plate  74  of the use indicator insert  70  has, around each individual access opening  76 , an individual precut system  78  which at least partially surrounds the associated individual access opening  76  and which comprises at least one or more precut line or lines  80 . 
     Each individual precut system  78  determines, after breaking of the precut line or lines, an individual extraction opening  82  which encompasses the individual access opening  76  and which has at least one transverse extraction dimension which is greater than a corresponding transverse dimension of the corresponding individual access opening  76 , so as to allow the individual article to pass. 
     Hence, it is understood that the packaging is designed such that a user is able to grasp an individual article using the access provided by the individual access opening  76 . This is done either by accessing the individual article through the individual access opening  76 , or because a portion of the individual article  12  projects, out of the lower portion  72  of the inner space, delimited by the opening indicator insert  70 , through the individual access opening  76 . An individual article  12  is illustrated in  FIG.  2   , in this case a syringe, which, in a storage configuration, is received in the packaging such that all of the body  14  of the syringe is received in the lower portion  72  of the inner space delimited by the opening indicator insert  70 . It is noted that, in this configuration, the collar  18  arranged at the upper end of the body  14  of the syringe is therefore located below the opening indicator insert  70 . On the other hand, it is observed that at least a part of the piston  16  of the syringe projects through the individual access opening  76 , above the use indicator insert  70 , such that it is easily accessible to the user when the upper leaf  52  of the packaging is open. In general, it can therefore be provided that the individual articles  12  each comprise an upper proportion  16  which projects above the use indicator insert  70 . The user is therefore able to grasp the individual article  12 , in this case the syringe, for example by gripping its piston  16 , in order to extract it from the packaging. In the example, the collar  18  of the body  14  of the syringe has a transverse dimension which is greater than the transverse dimension of the individual access opening  76 , in this case the diameter of the circular orifice acting as individual access opening  76 . 
     In certain embodiments, at least one individual precut system  78  completely surrounds the associated individual opening. 
     In the example of  FIGS.  1 ,  3  and  5   , an individual precut system  78  comprises a precut line  80  which completely surrounds the associated individual opening  76  and which delimits, in the transverse plate of the use indicator insert, a ring  84  which, by breaking the precut line  80 , detaches itself from the transverse plate. In the example, it can indeed be seen that an individual precut system  78  is arranged around the individual access opening  76 , in this case in the form of a precut line  80  which extends around the individual access opening  76 . In this case, the precut line  80  defines a ring  84  of substantially annular shape. In the example of  FIGS.  1 ,  3  and  5   , the precut line  80  is substantially concentric with the circle of the individual access opening  76 , but has a larger diameter. It is understood that, when the user extracts the individual article  12  from the packaging, in this case by an upward tensile force, the collar  18  not being able to pass through the individual access opening  76 , will cause the precut line  80  which delimits the ring  84  forming the use indicator to break, and will therefore cause the separation of the ring  84  forming the use indicator relative to the transverse plate  74  of the use indicator insert  70 . The separation of the ring  84  forming the use indicator clearly and visibly indicates to the user that the individual article corresponding to the individual access opening  76  in question has been extracted from the packaging, even if this article is then replaced in the packaging at the same location. In the example of  FIGS.  1 ,  3  and  5   , the ring  84  is therefore intended to be entirely detached from the transverse plate  74  of the use indicator insert  70 . Once detached, the ring  84  leaves a space in the transverse plate  74 , at the individual extraction orifice  82 , the dimensions of which are such that they allow the individual article  12  to pass without difficulty. In other words, the transverse dimensions of each individual article  12  are less than the transverse dimensions of the individual extraction opening  82  which is associated with this article. 
     In the example of  FIGS.  1 ,  3  and  5   , the individual access openings  76  are arranged along two parallel lines of five units each. It is observed that, when two individual access openings  76  which are contiguous on the same line are considered, the rings  84  associated with these two individual access openings  76  are joined by a common edge  86 . The common edge  86  is preferably a portion of the precut line  80 , and still more preferably, the common edge  86  is a portion of the precut line  80  which is entirely cut in order to ensure that, when a first of the two rings  84  is detached from the transverse plate  74  at the time of the extraction of the corresponding individual article, the other of the two rings, joined to the first, is not subject to any force coming from the first ring  84  and that would risk causing the detachment of this second ring. However, the common edge  86  could be a portion of the precut line  80  that is not entirely cut, having therefore, along the common edge  86 , connection points between the joined rings  84  associated with these two contiguous individual access openings  76 , but preferably with a minimal tear strength. Furthermore, it is observed that, in this example, when two individual access openings  76  that are not on the same line are considered, the rings  84  respectively associated with these two individual access openings  76  are not joined and therefore do not have a common edge. 
     In others embodiments, such as that illustrated in  FIG.  4    and  FIG.  7   , at least one individual precut system  78  only partially surrounds the associated individual access opening  76  and delimits, in the transverse plate  74  of the use indicator insert  70 , at least one leaf  88  which, after breaking of the precut line or lines  80 , remains attached to the transverse plate  74  by a non-precut connection region, while being able to pivot around a fold line  90  which extends transverse to the connection region. By pivoting, the one or more leafs  88  transform the individual access opening  76  into an individual extraction opening  82  allowing the individual article  12  to be extracted. 
     In the example of  FIGS.  4  and  7   , it is observed that each individual access opening  76  is surrounded by two leafs  88 . Each leaf is delimited by precut lines  80  and by a fold line  90  in a non-precut connection region which ensures that the leaf  88  remains integral with the opening indicator insert  70  even when the precut lines  80  of the individual precut system are broken. Each leaf  88  therefore has an edge which is formed by a portion of the edge of the associated individual access opening  76 . In the example, the two leafs  88  are arranged diametrically opposite, on each side of the individual access opening  76 . Before breaking the individual precut system  78 , the two leafs  88  are connected to one another by a junction edge  92  common to the two leafs, this junction edge  92  itself also being produced in the form of a precut line which is caused to break in order, during the extraction of an individual article, to enable the separation of the two leafs  88  associated with a given individual access opening  76 . Indeed, it is noted that the fold lines  90  of the two leafs associated with a given individual access opening  76  are arranged on either side of the individual access opening  76  considered. By contrast, the junction edge  92  of the two leafs extends in a diametric direction relative to the individual access opening  76 . In the illustrated example, the junction edge  92  of the two leafs  88  associated with an individual access opening  76  is substantially parallel to the two fold lines  90  of these two leafs  88 . 
     The fold line  90  of each leaf  88  is preferably a premarked fold line, produced for example in the form of a crease in the cardboard, but this is not compulsory. 
     In the example of  FIGS.  4  and  7   , the individual access openings  76  are arranged along two parallel lines of five units each. It is observed that, when two individual access openings  76  which are contiguous on a given line are considered, two leafs  88  each associated with these two individual access openings  76  are joined by a common edge  94 . The common edge  94  is preferably a portion of the precut line  80 , and still more preferably, the common edge  94  is a portion of the precut line  80  which is entirely cut in order to ensure that, when a leaf  88  associated with one of the individual access openings  76  is pivoted relative to the transverse plate  74  at the time of extraction of the corresponding individual article, the other of the leafs  88 , joined to the first leaf but associated with the second individual access opening  76 , is not subject to any force coming from the first leaf  88  and which would risk causing it to pivot relative to the plane of the transverse plate  74 . However, the common edge  94  could be a portion of the precut line  80  which is not entirely cut, having therefore, along the common edge  94 , connection points between the joined leafs  88  associated with these two contiguous individual access openings  76 , but preferably with a minimal tear strength. Furthermore, it is observed that, in this example, when two individual access openings  76  are considered which are not on the same line, the leafs  88  respectably associated with these two individual access openings  76  are not joined, and therefore do not have a common edge. 
     In general, a use indicator insert can comprise individual precut systems  78  of different geometries from one another, in particular in the case of packaging  10  for receiving individual articles of several types within the same packaging. Typically, such individual precut systems  78  with different geometries can have one or more precut lines of different geometries between two individual precut systems  78 . For example, a given opening indicator insert may have one or more individual precut systems  78  having the geometry illustrated in  FIG.  3   , and one or more individual precut systems  78  having the geometry illustrated in  FIG.  4   . 
     In order that the extraction of the individual article  12  ensures the breaking of the individual precut system  78 , anchoring means are advantageously provided for ensuring the anchoring of the use indicator insert  70  in the packaging case  20 . These anchoring means can take various forms, in particular one or other or a combination of the following forms. Firstly, the anchoring means can include gluing or stapling of the use indicator insert  70  in the packaging case  20 . In other embodiments, when the opening indicator insert  70  is produced in a single piece with the blank  24  from which the packaging case  20  is formed, the anchoring means can be constituted, at least in part, by a connection region between the opening indicator insert  70  and the packaging case  20 . However, in the illustrated embodiments, the anchoring means comprise at least one anchoring tab  140 , integral with one among the use indicator insert and another element of the packaging  10 , and an anchoring slot  142  arranged in the other among the use indicator insert and the other element of the packaging  10 , this other element of the packaging  10  being able to be, for example, the packaging case  20  itself or even the enclosure  22  or, as will be seen below, an internal element such as an internal wedging. 
     In the packaging example 10 illustrated in the figures, the packaging  10  comprises at least one internal wedging  100 ,  120  which is obtained from at least one blank cut from a sheet of cardboard. It will be seen, more particularly, that in the illustrated example, the packaging  10  comprises a lower internal wedging  100  and an upper internal wedging  120 . In the two cases, the internal wedging  100 ,  120  is received in the inner space of the packaging case  20 . More precisely, it is received in the lower portion  72  of the inner space of the packaging case. In all cases, the internal wedging  100 ,  120  has a number of wedging shapes  102 ,  122  corresponding to the determined number of individual articles. These wedging shapes  102 ,  122  have a geometry matched to that of the individual article  12  in order to receive and wedge the latter in the packaging, in particular during transport. Each wedging shape  102 ,  122  is suitable for wedging the individual article  12  in at least one spatial direction, in particular in a transverse direction of the packaging, but also optionally, in addition or as an alternative, in the longitudinal direction of the packaging  10 . 
     Preferably, the internal wedging  100 ,  120  determines a position and an orientation of each individual article  12  relative to an individual access opening  76  which is associated with this individual article  12  by the internal wedging. In the example, the internal wedging  100 ,  120  determines a position of each syringe and a longitudinal orientation of each syringe  12  relative to an individual access opening  76  associated with this syringe  12  such that the piston  16  projects above the opening indicator insert  70 , through the associated individual access opening. 
     In the example illustrated in the figures, the packaging  10  therefore comprises a lower internal wedging  100  and an upper internal wedging  120  which have a similar structure. The upper internal wedging  100  is arranged, in the inner space of the packaging, above the lower internal wedging  100 . 
     The lower internal wedging  100  has a transverse plate  104  intended to be oriented in a plane perpendicular to the longitudinal direction of the packaging. In the transverse plate  104 , the wedging shapes are produced in the form of orifices  102 , the cross-section of which corresponds to the cross-section of the individual article  12 , in this case more particularly the cross-section of the body  14  of the corresponding syringe  12 . When an individual article  12  is in the packaging, it is received in the wedging shape  102  of the lower internal wedging  100 , so as to be held here in the two transverse directions of the packaging  10 . 
     In the illustrated example, the lower internal wedging  100  is produced in a single piece with the cut blank  24  from which the enclosure  22  of the packaging case  20  is obtained. According to an advantageous aspect, illustrated more particularly in  FIG.  2    and in  FIG.  6   , the lower internal wedging  100  is arranged, in the blank  24 , in the extension of the lower flap  62 . 3  which is associated with the front main panel  26 . 3 . In the example, this lower flap  62 . 3  therefore extends from the lower edge  40 . 3  of the front main panel  26 . 3  to an opposite parallel edge  106  and has, between these two edges, a dimension which is equal to the transverse dimension of the side panel  26 . 4 , which corresponds to a dimension of the enclosure  22  that can be referred to as the transverse depth. In this way, when the packaging case  20  is assembled, therefore when the lower flap  62 . 3  is folded over at an angle of 90 degrees in a transverse plane perpendicular to the longitudinal direction of the packaging  10 , the lower flap  62 . 3  partly forms the bottom of the packaging case  20  and the opposite parallel edge  106  comes into contact, or almost into contact, with the rear main panel  26 . 1 . It can be seen that the transverse plate  104  of the lower internal wedging  100  is connected to the opposite parallel edge  106  of the lower flap  62 . 3  by an intermediate lower panel  108 . This intermediate lower panel  108  is intended to be folded upwards through 90° relative to the lower flap  62 . 3  such that, when the packaging case  20  is assembled, the intermediate lower panel  108  extends vertically in a longitudinal plane parallel to the rear main panel  26 . 1 , in parallel and in contact therewith. The transverse plate  104  of the lower internal wedging  100  is connected to the intermediate lower panel  108  at a rear width edge  110 , and it is itself intended to be folded through 90° to the horizontal relative to the intermediate lower panel  108  around the rear width edge  110 , in the same direction of rotation as the folding of the intermediate lower panel  108  relative to the lower flap  62 . 3 . Hence, the transverse plate  104  of the lower internal wedging  100  extends in a transverse plane perpendicular to the longitudinal direction of the packaging  10 , being longitudinally offset, towards the interior of the inner space, in this case upwards, relative to the bottom of the packaging case, by a distance equal to the dimension of the intermediate lower panel  108  between the opposite parallel edge  106  of the lower flap  62 . 3  and the rear width edge  110 . At a front width edge  112  of the transverse plate  104 , parallel and opposite to the rear width edge  110  relative to the transverse plate  104  of the lower internal wedging  100 , the latter has a fixing flap  114  for fixing the internal wedging which, after folding through 90°, for example upwards, can be fixed, for example by gluing, on an inner face of the front main panel  26 . 3 . The transverse plate  104  of the lower internal wedging  100  has, between its rear width edge  110  and its front width edge  112 , substantially the same transverse depth dimension as the inner space of the enclosure  22  of the packaging case  20 , so as to be wedged in this transverse depth direction in the inner space of the case  20 . After fixing the fixing flap  114 , the transverse plate  104  of the lower internal wedging  100  is also wedged longitudinally in this inner space, on the one hand, at the front by the fixing flap  114  which is fixed on the front main panel  26 . 3  and, on the other hand, at the rear by the intermediate lower panel  108 . The fixing flap  114  could be replaced by a support flap folded downwards in parallel and in contact with the inner face of the front main panel  26 . 3 , as will be described below for the upper internal wedging  120 . 
     The upper internal wedging  120  has a transverse plate  124  intended to be oriented in a plane perpendicular to the longitudinal direction of the packaging. In the transverse plate  124 , the wedging shapes are produced in the form of orifices  122 , the cross-section of which corresponds to the cross-section of the individual article  12 , in this case more particularly the cross-section of the body  14  of the corresponding syringe  12 . When an individual article  12  is in the packaging, it is received in the wedging shape  122  of the upper internal wedging  120 , so as to be held here in the two transverse directions of the packaging  10 . 
     In the illustrated example, the upper internal wedging  120  is produced in a single piece with the cut blank  24  from which the enclosure  22  of the packaging case  20  is obtained. According to an advantageous aspect, visible more particularly in  FIG.  2    and in  FIG.  6   , the lower internal wedging  120  extends in the blank  24 , from the upper edge  38 . 3  of the front main panel  26 . 3 . Firstly it has an upper intermediate panel  128  which extends from the upper edge  38 . 3  of the front main panel  26 . 3  to a front width edge  130 . The upper intermediate panel  128  is folded downwards through an angle of 180 degrees, against an inner face of the front main panel  26 . 3 . The transverse plate  124  of the upper internal wedging  120  is connected to the upper intermediate panel  128  at the front width edge  130 , and it is itself intended to be folded through 90° relative to the upper intermediate panel  128  around the front width edge  130 , to the horizontal, in the direction of rotation opposite to the direction of folding of the upper intermediate panel  128  relative to front main panel  26 . 3 . Hence, the transverse plate  124  of the upper internal wedging  120  extends in a transverse plane perpendicular to the longitudinal direction of the packaging  10 , being longitudinally offset, towards the interior of the inner space, therefore in this case downwards, relative to the upper edge  38 . 3  of the front main panel  26 . 3  of the packaging case, by a distance equal to the dimension of the upper intermediate panel  128  between the upper edge  38 . 3  of the front main panel  26 . 3  and the front width edge  130 . At a rear width edge  132  of the transverse plate  124 , parallel and opposite to the front width edge  130  relative to the transverse plate  124  of the upper internal wedging  120 , this latter has a support flap  134  of the upper internal wedging  130  which, after folding through 90°, in this case downwards, can be slid parallel to and in contact with an inner face of the rear main panel  26 . 1 , between the rear main panel  26 . 1  and the intermediate lower panel  108  of the lower internal wedging  100 , in order to come to abut by a free edge  136  against the bottom of the case  20 . The transverse plate  124  of the upper internal wedging  120  has, between its front width edge  130  and its rear width edge  132 , substantially the same transverse depth dimension as the enclosure  22  of the packaging case  20 , so as to be wedged in this transverse depth direction in the inner space of the case  20 . After the abutment of the support flap  134  against the bottom of the case  120 , the transverse plate  124  is also longitudinally wedged in this inner space, on the one hand at the rear, by the support flap  134  which is in abutment at the bottom of the case  20 , and on the other hand, at the front by the upper intermediate panel  128 . It is noted that, instead of the support flap  134 , the upper internal wedging  120  could be provided with a fixing flap analogous to that of the lower internal wedging  100 , which, after folding through 90° (upwards or downwards) could be fixed, for example by gluing, on an inner face of the rear main panel  26 . 1 . 
     It can be seen in the illustrated example, in particular in  FIGS.  1 ,  2  and  5   , that the upper internal wedging  120  also comprises side flaps  138  which extend from the side edges of the transverse plate  124 . The side flaps  138  are intended to be folded through an angle of 90° upwards relative to the transverse plate  124  in order to extend upwards along each of an inner face of one of the main side panels  26 . 2 ,  26 . 4  of the case  20 . Advantageously, their size can be such that they extend up to the upper edge  38 . 2 ,  38  of the corresponding main side panel. In this way, when the upper leaf  52  is closed, the side flaps  138  are blocked from moving upwards by the upper leaf  52  and thus block the upward movement of the transverse plate  124  of the upper internal wedging  120 . 
     In the presence of an internal wedging  100 ,  120 , the anchoring means advantageously ensures a connection between the use indicator insert  70  and the internal wedging  100 ,  120  in order to ensure the anchoring of the use indicator insert  70  in the packaging case  20 . Indeed, by anchoring the use indicator insert  70  on an internal structure inside the inner space delimited by the enclosure  22  of the packaging case  20 , it is possible to produce a simpler mounting of the use indicator insert  70 , not impacting on the enclosure  22 . In the example comprising a lower internal wedging  100  and an upper internal wedging  120 , the latter being arranged above the lower internal wedging  100 , the anchoring means advantageously ensure a connection between the use indicator insert  70  and the upper internal wedging  120  in order to ensure the anchoring of the use indicator insert  70  in the packaging case  20 . It is understood that the use indicator insert  70  is arranged above the upper internal wedging  120  in the packaging case  20 . 
     In the example, the anchoring means comprise at least one anchoring tab  140 , integral with one among the use indicator insert  70  and the internal wedging (in the example the upper internal wedging  120 ), and an anchoring slot  142  arranged in the other among the use indicator insert  70  and the internal wedging  120 . The anchoring tab  140  comprises an anchoring shape enabling the insertion of the anchoring tab  140  in the anchoring slot  142  and opposing the withdrawal of the anchoring tab relative to the anchoring slot  142 . 
     In the illustrated examples, the anchoring tabs  140  each extend in the extension of a side flap  144  of the use indicator insert  70  which extends itself from a side edge  146  of the transverse plate  74  of the use indicator insert  70 . The side flap is intended to be folded through 90° relative to the transverse plate  74  of the use indicator insert  70 , to the vertical downwards. In the example, it is envisaged that the lower edge  148  of each side flap  144  of the use indicator insert  70  comes into contact downloads on the transverse plate  124  of the internal wedging, in this case the upper internal wedging  120 . This support of the side flaps  144  on the transverse plate  124  of the internal wedging makes it possible to position and stabilise the opening indicator insert  70  in the inner space of the packaging. 
     In the illustrated example, the anchoring tab  140  extends from the lower edge  148  of the corresponding side flap  144  of the opening indicator insert  70 . For example, the anchoring tab  140  has the shape of a flat arrow in the plane defined by the corresponding side flap  144 . The anchoring tab  140  can thus have an arrow tip  147  which is attached to the lower edge  148  of the corresponding side flap by an arrow stem  149 . The arrow tip is pointed away from the lower edge of the corresponding side flap  144 . 
     For its part, each anchoring slot  142  is arranged at a side edge  126  of the transverse plate  124  of the upper internal wedging  120 , in this case a side edge  126  from which the side flap  138  of the upper internal wedging  120  extends. 
       FIGS.  8  and  9    show a particularly advantageous configuration of the anchoring slot  142 . This configuration will be described in the illustrated case, in which the anchoring slot is arranged on an upper internal wedging  120 , the anchoring tab  142  being carried by the opening indicator insert  70 . However, an analogous configuration is possible in the inverse case, with the anchoring slot  142  arranged on the opening indicator insert  70  and the anchoring tab  140  arranged on an internal wedging. 
     Indeed, the anchoring slot  142  is arranged at a side edge of a transverse plate  124 , in this case that of the upper internal wedging  120 , from which a flap extends, in this case the side flap  138 , which is folded through 90° by folding along a fold line which corresponds to the side edge  126 . This side edge  126  defines a fold line having a folding axis A 126 . The flap, in this case the side flap  138 , is folded over towards the direction from which the anchoring tab  140  must be inserted into the anchoring slot  142 .  FIG.  8    illustrates an embodiment of the anchoring slot  142  at the fold line of the side edge  126 . It can be seen that the anchoring slot  142  comprises a central lumen  160 , which has a certain width in the direction perpendicular to the folding axis A 126 . This width is, for example, several millimetres, in any case greater than the thickness of the cardboard in which the anchoring tab  140  is produced. The central lumen  160  has a size, in the direction of the folding axis A 126 , which is greater than that of the arrow stem  149  of the anchoring tab  140 , but less than the size, in the direction of the folding axis A 126 , of the arrow tip  147 . On each side of the central lumen  160  in the direction of the folding axis A 126 , the anchoring slot  142  has junction cuts  162  which join the corresponding end of the central lumen  160  to the fold line  126 . These junction cuts  162  are preferably produced in the form of a simple cut line in the cardboard. These junction cuts  162  have a size, in the direction of the folding axis A 126 , which is such that the total size of the anchoring slot in this direction is at least equal to that of the arrow tip  149  of the anchoring tab  140 . Hence, the arrowhead  149  is able to be inserted through the anchoring slot  140  without being deformed. As can be seen in  FIG.  8   , the junction cuts  162  have an offset relative to the folding axis A 126 , in the direction of the flap  138 , in order to define transverse projections  164  of the transverse plate which extend the transverse plate  124  beyond the folding axis A 126 . In the illustrated example, the offset of the junction cuts  162  is in the form of an inclination of each junction cut  162  relative to the folding axis A 126  in the plane of the transverse plate  124 . In the illustrated example, each junction cut  162  is produced in the form of a segment, in this case a straight segment, which has a distal end  162   d  which joins the fold line  126  on the folding axis A 126 , and a proximal end  162   p  which opens into the central lumen  160  and which is offset relative to the folding axis A 126  in the direction of the flap  138 . It is understood that, when the flap  138  is folded over perpendicularly to the transverse plate  124 , as illustrated in  FIG.  9   , it is aligned with the folding axis A 126 . By contrast, as can be seen in  FIG.  9   , the transverse projections  164 , which are each separated from the flap  138  by the corresponding junction cut  162 , remain in the plane of the transverse plate  124  and extend beyond the folding axis  126 . In the described configuration, in which the flaps  138  are folded over upwards, the projections  164  are then below the flap plane  138 . When the anchoring tab  140  is inserted in the anchoring shape  142 , in this case from above, the transverse ends of the arrow tip  147  slide under the transverse projections  164 . Any force exerted on the anchoring tab  140  in the direction of its extraction from the anchoring slot  142  means that the transverse ends of the arrow tip  147  come into abutment from the bottom against the transverse projections  164 . However, these projections  164  are blocked from moving upwards by the flap  138  which is folded over upwards and they therefore prevent any deformation of the transverse plate  124  which could enable an extraction without damage to the arrow tip  147 . This configuration of the anchoring slot  142  is therefore particularly advantageous because it enables easy insertion of the anchoring tab, by deforming the transverse projections  164  downwards, a deformation which is not counteracted. On the contrary, any upward deformation of the transverse projections  164  is counteracted by the abutment of these transverse projections  164  against the edge of the flap  138  folded over upwards. 
     Furthermore, it is noted that in the illustrated examples, the use indicator insert  70  also comprises a front flap  150  and a rear flap  152  which each extend respectively from a front edge  154  and a rear edge  156  of the transverse plate  74  of the use indicator insert  70 , which are each intended to be folded through 90° relative to the transverse plate  74  of the use indicator insert  70 . Such 90° flaps make it possible to rigidify the use indicator insert  70 . Optionally, such flaps can be folded vertically downwards, and they are sized such that a lower edge  158 ,  160  of each front flap  150  and rear flap  152  of the use indicator insert  70  comes into abutment downwards on the transverse plate  124  of the internal wedging, in this case the upper internal wedging  120 . In this case, this abutment also makes it possible to position and stabilise the opening indicator insert  70  in the inner space of the packaging. In the examples illustrated, the front  150  and rear  152  flaps do not have an anchoring tab, but it could be provided that they have, in addition or as an alternative, anchoring tabs  142  carried by the side edges  144 . 
     Advantageously, the use indicator insert  70  is arranged in the packaging at a predetermined non-zero distance from the upper longitudinal end of the enclosure  22 , towards the interior in the longitudinal direction. This makes it possible, in particular, that the individual articles have a portion which projects above the opening indicator insert, without leaving the volume of the inner space of the packaging. Thus by projecting above the opening indicator insert  70 , the articles can be easily grasped by the user. 
     In certain embodiments, the use indicator insert  70  can also be obtained from the same blank as the packaging case  20 . For example, starting from the blank  24  illustrated in  FIG.  2   , it is possible to have a use indicator insert  70 , for which the transverse plate  74  of the use indicator insert would be connected, via an intermediate panel, to an upper edge  40 . i  of one of the main panels. This intermediate panel would form a part of the anchoring means, it being possible to form another part for example, in an analogous manner to that which has been described above, by an anchoring tab carried by a flap arranged opposite the intermediate panel relative to the transverse plate  74 . Such a configuration is compatible with a case  20  comprising both a lower internal wedging  100  and an upper internal wedging  120  as described above. Indeed, it would be possible to have a use indicator insert  70  for which the transverse plate  74  of the use indicator insert would be connected, via said intermediate panel, to the upper edge  38 . 2 ,  38 . 4  of one or other of the main side panels  26 . 2 ,  26 . 4 . In the case of a packaging case not comprising any upper internal wedging incorporated in the same blank as the enclosure  22  of the case  20 , it is possible that the transverse plate  74  of the use indicator insert is connected, via said intermediate panel, to the upper edge  38 . 2 ,  38 . 4 ,  38 . 3  of one or other of the main side panels  26 . 2 ,  26 . 4  or of the front main panel  26 . 3 , the use indicator insert which would take the place, in the blank  24 , of the upper internal wedging. In such a case therefore, in the absence of upper internal wedging, it would be possible to provide, for example, the anchoring means ensuring a connection between the use indicator insert and the lower internal wedging. 
     The use indicator insert does not necessarily absolutely guarantee detection of a prior extraction of a considered article. However, in particular through a judicious choice of relative shapes and strengths, in particular relative strength of the precut lines  80 , the use indicator insert can constitute a tamper indicator device for the individual article.