Patent Publication Number: US-2015072021-A1

Title: Methods and Kits for Predicting Outcome and Methods and Kits for Treating Breast Cancer with Radiation Therapy

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application claims priority to U.S. Provisional Patent Application Ser. No. 61/875,373 filed Sep. 9, 2013 and to U.S. Provisional Patent Application Ser. No. 61/990,948 filed May 9, 2014, the contents of which are herein incorporated by reference in their entirety. 
    
    
     FIELD OF THE INVENTION 
     This disclosure relates generally to the field of cancer biology, and specifically, to the fields of detection and identification of specific cancer cell phenotypes and correlation with appropriate therapies. 
     INCORPORATION BY REFERENCE OF SEQUENCE LISTING 
     The contents of the text file named “NATE-022001US_ST25.txt”, which was created on Sep. 8, 2014 and is 328,667 bytes in size, are hereby incorporated by reference in their entireties. 
     BACKGROUND OF THE INVENTION 
     Radiation therapy (also known as radiotherapy or radiation oncology) is often utilized following lumpectomy or mastectomy to reduce or control malignant cancer cells that remain post-surgery, i.e., as an adjuvant therapy, and is known to lower the chances of breast cancer recurrence and breast cancer death. Radiation is used after mastectomy to treat the chest wall and the lymph nodes around the collarbone and axillary nodes in the underarm area. However, there are various adverse side effects associated with radiation therapy, such as nausea and vomiting, intestinal discomfort, mouth, throat and stomach sores, damage to epithelial surfaces, edema, infertility, fibrosis, lymphedema, hypopituitarism and epilation. Thus, there is a need in the art to determine types of cancer and identifying subjects having such cancer types that respond best to radiation-based therapy and which types of cancer and subjects having such cancer types would be better treated with non-radiation-based therapy; accordingly, an optimal treatment is provided to the subject in need thereof. The present invention addresses these needs. 
     SUMMARY OF THE INVENTION 
     The present invention provides a method of predicting local-regional relapse free, or breast cancer specific survival in a subject having a breast cancer including steps of: (a) obtaining a biological sample from the subject and (b) assaying the biological sample to determine whether the biological sample is classified as a Luminal A subtype, Luminal B subtype, Basal-like subtype, or HER2-enriched subtype, wherein the subtypes are determined using a measurement of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1, wherein (1) if the biological sample is classified as a Luminal A subtype or Basal-like subtype, a post-mastectomy breast cancer treatment including radiation is more likely to prolong local-regional relapse free survival or breast cancer specific survival of the subject or (2) if the biological sample is classified as a Luminal B subtype or HER2-enriched subtype, a post-mastectomy breast cancer treatment including radiation is not likely to prolong local-regional relapse free survival or breast cancer specific survival of the subject. 
     The present invention also provides a method of screening for the likelihood of the effectiveness of a post-mastectomy breast cancer treatment including radiation in a subject in need thereof including steps of: (a) obtaining a biological sample from the subject and (b) assaying the biological sample to determine whether the biological sample is classified as a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype, wherein the subtype is determined using a measurement of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1, wherein (1) if the biological sample is classified as a Luminal A subtype or Basal-like subtype, the post-mastectomy breast cancer treatment including radiation is more likely to be effective in the subject or (2) if the biological sample is classified as a Luminal B subtype or HER2-enriched subtype, the post-mastectomy breast cancer treatment including radiation is not likely to be effective in the subject. 
     The present invention also provides a method of treating breast cancer in a subject in need thereof including steps of: (a) obtaining a biological sample from the subject, (b) assaying the biological sample to determine whether the biological sample is classified as a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype, wherein the subtype is determined using a measurement of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1, and (c) administering a breast cancer treatment to the subject, wherein (1) if the biological sample is classified as a Luminal A or Basal-like subtype, the subject is administered a post-mastectomy breast cancer treatment including radiation or (2) if the biological sample is a Luminal B or HER2-enriched subtype, the subject is administered a breast cancer treatment not including radiation, thereby treating breast cancer in the subject. 
     In any of the above methods, preferably, the subtypes are determined using expression levels (e.g., RNA expression levels) of at least 40 of the genes listed in Table 1, e.g., 46 or 50 of the genes listed in Table 1. The step of assaying may include detecting expression levels of at the least the following 24 genes from the at least 40 of the genes listed in Table 1, i.e., FOXA1, MLPH, ESR1, FOXC1, CDC20, ANLN, MAPT, ORC6L, CEP55, MKI67, UBE2C, KNTC2, EXO1, PTTG1, MELK, BIRC5, GPR160, RRM2, SRFP1, NAT1, KIF2C, CXXC5, MIA and BCL2. Expression levels of CCNE1, CDC6, CDCA1, CENPF, TYMS, and UBE2T may additionally be detected. In embodiments, expression level of each gene in the NANO46 gene set (which is all 50 genes in Table 1 with the exception of MYBL2, BIRC5, GRB7 and CCNB1) is detected. Additionally, expression levels of housekeeping genes may be detected. Expression levels of the at least 40 genes as well as a plurality of (e.g., eight or more) housekeeping genes can be detected in a single hybridization reaction. Expression levels of the at least 40 genes may be normalized to expression levels of the plurality of housekeeping genes. To control for any differences in the intact RNA amount in the reference sample, the levels of the at least 40 genes are normalized against the mean of the level of plurality of housekeeping genes. 
     A synthetic RNA reference sample, comprising in vitro transcribed RNA targets from the at least 40 genes and the plurality of housekeeping genes, may be assayed and used as a control. Further, to control for any variation in the assay procedure, the above normalized expression levels for each of the at least 40 genes from a biological sample are then further normalized to the normalized levels from each of the at least 40 genes of the synthetic reference sample. The normalized gene expression levels are then log transformed and scaled using two scaling factors. 
     The step of assaying may include one or more steps of generating a gene expression profile based on expression of the genes in the biological sample, comparing the gene expression profile for the biological sample to centroids constructed from gene expression data for the at least 40 of the genes listed in Table 1 for the Luminal A, Luminal B, HER2-enriched or Basal-like subtypes, utilizing a supervised algorithm and calculating the distance of the gene expression profile for the biological sample to each of the centroids, and classifying the biological sample as a Luminal A, Luminal B, HER2-enriched or Basal-like subtype based upon the nearest centroid. More specifically, a computational algorithm based on a Pearson&#39;s correlation compares the normalized and scaled gene expression profile of the entirety of the at least 40 genes from the biological sample to prototypical expression signatures (termed “centroids”) which define each of the four breast cancer intrinsic subtypes, e.g., derived from gene expression data deposited with the National Center for Biotechnology Information Gene Expression Omnibus (GEO) (as examples, with accession number GSE2845 or GSE10886). The Pearson&#39;s correlation calculation assigns the patient breast tumor sample to the intrinsic subtype with the most similar expression profile or centroid score across the at least 40 genes. The Pearson&#39;s correlation of the totality of the at least 40 genes to the four centroids results in four numerical values that each range from −1 to +1 where a value of +1 is a perfectly correlated expression profile, −1 is a perfectly anti-correlated profile and 0 is completely uncorrelated. Features of the above-mentioned steps are included in the “PAM50 classification model” or the “NANO46 classification model”, as described below. 
     At least one of the above described steps is performed on a computer or electronic computational device. 
     In embodiments, assaying includes detecting expression levels of HER2. 
     The breast cancer can be primary breast cancer, locally advanced breast cancer or metastatic breast cancer. The subject can be a mammal. Preferably, the subject is human. The subject may be a male or a female. The subject has been diagnosed by a skilled artisan as having a breast cancer and is included in a subpopulation of humans who currently have breast cancer or had breast cancer. The subject that has breast cancer can be pre-mastectomy or post-mastectomy. Preferably the subject is post-mastectomy. The subject may have undergone breast-conserving therapy. The subject that has breast cancer may have been previously been treated with an anti-cancer or chemotherapeutic agent. Preferably the subject has not been previously treated with an anti-cancer agent or chemotherapeutic agent. The subject may have been previously been treated with radiation. Preferably the subject has not been previously treated with radiation. The subject can be pre-menopausal or post-menopausal. Preferably, the subject is pre-menopausal. The subject can have node-positive breast cancer. Preferably, the subject has node-positive breast cancer. The subject can have estrogen receptor positive or estrogen receptor negative breast cancer. The subject that has estrogen receptor positive breast cancer may also undergo or be subjected to oophorectomy, alone or in addition to other breast cancer treatments. The subject may have Stage I or II, lymph node-negative, breast cancer or Stage II, lymph node positive, breast cancer. 
     The breast cancer treatment that includes radiation can also include one or more anti-cancer or chemotherapeutic agents. Classes of anti-cancer or chemotherapeutic agents can include anthracycline agents, alkylating agents, nucleoside analogs, platinum agents, taxanes,  vinca  agents, anti-estrogen drugs, aromatase inhibitors, ovarian suppression agents, endocrine/hormonal agents, bisphophonate therapy agents and targeted biological therapy agents. Specific anti-cancer or chemotherapeutic agents include cyclophosphamide, fluorouracil (or 5-fluorouracil or 5-FU), methotrexate, thiotepa, carboplatin, cisplatin, gemcitabine, anthracycline, taxanes, paclitaxel, protein-bound paclitaxel, docetaxel, vinorelbine, tamoxifen, raloxifene, toremifene, fulvestrant, irinotecan, ixabepilone, temozolmide, topotecan, vincristine, vinblastine, eribulin, mutamycin, capecitabine, capecitabine, anastrozole, exemestane, letrozole, leuprolide, abarelix, buserlin, goserelin, megestrol acetate, risedronate, pamidronate, ibandronate, alendronate, denosumab, zoledronate, trastuzumab, tykerb or bevacizumab, or combinations thereof. Preferably, the treatment that includes radiation also includes cyclophosphamide, fluorouracil (or 5-fluorouracil or 5-FU), methotrexate, or combinations thereof one such combination is CMF which includes cyclophosphamide, methotrexate, and fluorouracil. 
     The assaying of the biological sample to determine whether the biological sample is classified as either a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype cancer is performed using RNA expression profiling, immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH). Preferably, the assay is RNA expression profiling. The expression of the members of the gene list of Table 1 can be determined using a nanoreporter and the nanoreporter code system (nCounter® Analysis system; NanoString Technologies, Seattle, Wash.). Preferably, expression of the members of the gene list of Table 1 can be determined using a reporter probe and capture probe for the detection of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1. In particular, expression of the “NANO46” set of genes is determined (which is by determining the expression of all 50 genes in Table 1 with the exception of determining the expression of MYBL2, BIRC5, GRB7 and CCNB1). Preferably, there is only one reporter probe/capture probe pair for any one gene of Table 1 to be detected. 
     The biological sample can be a cell, a tissue or a bodily fluid. The tissue can be sampled from a biopsy or smear. The biological sample can be a tumor. The tumor can be an estrogen receptor positive tumor or an estrogen receptor negative tumor. The sample can also be a sampling of bodily fluids. The bodily fluid can include blood, lymph, urine, saliva, nipple aspirates and gynecological fluids. The biological sample can be a formalin fixed paraffin embedded tissues (FFPE) sample. 
     When a biological sample is classified as either a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype cancer, the subject from which the biological sample is obtained is classified as having, respectively, a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype cancer. A subject is assigned to a recommended treatment group based on his/her classified cancer subtype. Finally, a recommend treatment to be provided to a subject depends on the group to which the subject is assigned. 
     In embodiments, a computational algorithm then calculates a Risk of Recurrence (ROR) score. In embodiments, the ROR score is calculated using coefficients from a Cox model that includes (1) Pearson&#39;s correlation of the expression profiles of the at least 40 genes (e.g., the NANO46 gene set) in the biological sample with the expected profiles for the four intrinsic subtypes (as described above), (2) a proliferation score (determined from the mean gene expression of a subset of 18 proliferation genes of the at least 40 genes (as described below) and (3) gross tumor size of the subject&#39;s tumor. The variables are multiplied by the corresponding coefficients from the Cox Model to generate the score, which is then adjusted to a 0-100 scale. The 0-100 ROR score is correlated with the probability of distant recurrence at ten years (Distant Recurrence-Free Survival (DRFS) at 10 years). Risk categories (low, intermediate, or high) are also calculated based on cut-offs for risk of recurrence score determined in a clinical validation study. 
     In embodiments, a risk of recurrence (ROR) score of 0 to 40 is a low risk of recurrence for a node-negative cancer, a ROR score of 0 to 15 is a low risk of recurrence for a node-positive cancer, a ROR score of 61 to 100 is a high risk of recurrence for a node-negative cancer, and a ROR score of 41 to 100 is a high risk of recurrence for a node-positive cancer. 
     As used herein a ROR score can be calculated using any method or formula known in the art. Exemplary formulae include Equations 1 to 6, as described herein. 
     The at least 40 genes set contains many genes that are known markers for proliferation. The methods and kits of the present invention provide for the determination of subsets of genes that provide a proliferation signature. The methods and kits of the present invention can include steps and reagents for determining the expression of at least one of, a combination of, or each of, a 18-gene subset of the intrinsic genes of Table 1 selected from ANLN, CCNE1, CDC20, CDC6, CDCA1, CENPF, CEP55, EXO1, KIF2C, KNTC2, MELK, MKI67, ORC6L, PTTG1, RRM2, TYMS, UBE2C and/or UBE2T. Preferably, the expression of each of the 18-gene subset of the gene set of Table 1 is determined to provide a proliferation score. The expression of one or more of these genes may be determined and a proliferation signature index can be generated by averaging the normalized expression estimates of one or more of these genes in a sample. The sample can be assigned a high proliferation signature, a moderate/intermediate proliferation signature, a low proliferation signature or an ultra-low proliferation signature. Methods of determining a proliferation signature from a biological sample are as described in Nielsen et al.  Clin. Cancer Res.,  16(21):5222-5232 (2009) and supplemental online material. 
     The present invention provides a kit for predicting local-regional relapse free or breast cancer specific survival in a subject having a breast cancer including reagents (e.g., sets of reporter/capture probes and/or primers) sufficient for detecting expression of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1; instructions for performing an assay to classify a biological sample from the subject as a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype, by using the reagents to detect or measure expression of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1; instructions providing information allowing a user to classify whether the biological sample from the subject is a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype by using the reagents to detect or measure expression at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1; and instructions for obtaining a prediction whether a treatment including radiation is more likely or not likely to prolong local-regional relapse free or breast cancer specific survival in the subject based on the classified cancer subtype, wherein (a) if the biological sample is classified as a Luminal A subtype or Basal-like, a post-mastectomy breast cancer treatment including radiation is more likely to prolong local-regional relapse free survival or breast cancer specific survival of the subject and (b) if the biological sample is classified as a Luminal B or HER2-enriched subtype, a post-mastectomy breast cancer treatment including radiation is not likely to prolong local-regional relapse free survival or breast cancer specific survival of the subject. The instructions may provide a recommended treatment for the subject based on the obtained prediction. The instructions may further specify how to determine a proliferation score/signature, how to utilize clinicopathological variables in calculations, and how to calculate risk of recurrence (ROR) scores/signatures, e.g., which may be based in part of expression data of the NANO46 set of genes. The kit may also contain reagents sufficient to facilitate detection and/or quantitation of HER2, in order to classify cells as HER2+. The kit may include a positive and/or negative control reference sample(s). The kit may include reagents for detecting expression of one or more housekeeping genes, DNA Repair genes, and/or tumor suppressor genes (e.g., RB1). The kit may further comprise a non-transitory computer readable medium including, at least, any of the above-described instructions. The kit may comprise an array. The kit may include reagents and instructions for determining a VEGF-signature score (as described below, including Table 7). 
     The present invention also provides a kit for screening for the likelihood of the effectiveness of a post-mastectomy breast cancer treatment including radiation in a subject in need thereof including reagents (e.g., sets of reporter/capture probes and/or primers) sufficient for detecting expression of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1; instructions for performing an assay to classify a biological sample from the subject as a Luminal A, Luminal B, HER2-enriched or Basal-like subtype, by using the reagents to detect or measure expression of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1; instructions providing information allowing a user to classify whether the biological sample from the subject is a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype by using the reagents to detect or measure expression of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1; and instructions for determining the likelihood of the effectiveness of a post-mastectomy breast cancer treatment including radiation in the subject based on the classified cancer subtype, wherein (a) if the biological sample is classified as a Luminal A or Basal-like subtype, a post-mastectomy breast cancer treatment including radiation is more likely to be effective in the subject or (b) if the biological sample is classified as a Luminal B or HER2-enriched subtype, a post-mastectomy breast cancer treatment including radiation is not likely to be effective in the subject. The instructions provide a recommended treatment based on the determined likelihood of effectiveness. The instructions may further specify how to determine a proliferation score/signature, how to utilize clinicopathological variables in calculations, and how to calculate risk of recurrence (ROR) scores/signatures, e.g., which may be based in part of expression data of the NANO46 set of genes. The kit may also contain reagents sufficient to facilitate detection and/or quantitation of HER2, in order to classify cells as HER2+. The kit may include a positive and/or negative control reference sample(s). The kit may include reagents for detecting expression of one or more housekeeping genes, DNA Repair genes, and/or tumor suppressor genes (e.g., RB1). The kit may further comprise a non-transitory computer readable medium including, at least, any of the above-described instructions. The kit may comprise an array. The kit may include reagents and instructions for determining a VEGF-signature score. 
     The present invention also provides a kit for treating breast cancer in a subject in need thereof including reagents (e.g., sets of reporter/capture probes and/or primers) sufficient for detecting expression of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1; instructions for performing an assay to classify a biological sample from the subject as a Luminal A, Luminal B, HER2-enriched or Basal-like subtype, by using the reagents to detect or measure expression of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1; instructions providing information allowing a user to classify whether the biological sample from the subject is a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype by using the reagents to measure at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1; and instructions for administering a post-mastectomy breast cancer treatment including radiation if the biological sample is classified as a Luminal A or Basal-like subtype and instructions for administering a post-mastectomy breast cancer treatment not including radiation if the biological sample is classified as a Luminal B or HER2-enriched subtype. The instructions may further specify how to determine a proliferation score/signature, how to utilize clinicopathological variables in calculations, and how to calculate risk of recurrence (ROR) scores/signatures, e.g., which may be based in part of expression data of the NANO46 set of genes. The kit may also contain reagents sufficient to facilitate detection and/or quantitation of HER2, in order to classify cells as HER2+. The kit may include a positive and/or negative control reference sample(s). The kit may include reagents for detecting expression of one or more housekeeping genes, DNA Repair genes, and/or tumor suppressor genes (e.g., RB1). The kit may further comprise a non-transitory computer readable medium including, at least, any of the above-described instructions. The kit may comprise an array. The kit may include reagents and instructions for determining a VEGF-signature score. 
     Preferably, the kit provides reagents sufficient for the detection of at least 40 of the genes listed in Table 1. Preferably, the kit provides reagents sufficient for the detection of at least 45 of the genes listed in Table 1, i.e., 46 of the genes listed in Table 1. The reagents sufficient for the detection of the at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1 can include an array (e.g., a microarray) or a microfluidic device. Preferably, the reagents include a reporter probe and capture probe for the detection of at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1. Preferably, the kit includes reagents sufficient to detect one or more housekeeping genes, DNA Repair genes, and/or tumor suppressor genes (e.g., RB1). Preferably, there is only one reporter probe/capture probe pair for any one gene of Table 1 to be detected or only one housekeeping gene. Preferably, the kit includes reagents sufficient to facilitate detection and/or quantitation of HER2. Preferably, the kit includes reagents sufficient to determine a VEGF-signature score. Preferably, the kit includes instructions for utilizing the reagents and for performing any of the methods provided in the instant invention. 
     The term “likely” as used herein has the meaning commonly understood by a person skilled in the art to which this invention belongs. For example, if a subject is “more likely” to benefit from a therapy, it would be recommended for a health care provider to select the therapy for the subject. 
     The term “measurement” as used herein includes obtaining, measuring, or detecting a numeric value of a quantifiable property, e.g., expression level of a gene, and also includes calculations using the value, e.g., the deviation of a gene&#39;s expression level in a test sample relative to a control sample, a correlation, and a statistic. 
     Any of the above aspects and embodiments can be combined with any other aspect or embodiment. 
     Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In the specification, the singular forms also include the plural unless the context clearly dictates otherwise; as examples, the terms “a,” “an,” and “the” are understood to be singular or plural and the term “or” is understood to be inclusive. By way of example, “an element” means one or more element. Throughout the specification the word “comprising,” or variations such as “comprises” or “comprising,” will be understood to imply the inclusion of a stated element, integer or step, or group of elements, integers or steps, but not the exclusion of any other element, integer or step, or group of elements, integers or steps. About can be understood as within 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 0.5%, 0.1%, 0.05%, or 0.01% of the stated value. Unless otherwise clear from the context, all numerical values provided herein are modified by the term “about.” 
     Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. The references cited herein are not admitted to be prior art to the claimed invention. In the case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and are not intended to be limiting. Other features and advantages of the invention will be apparent from the following detailed description and claim. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The above and further features will be more clearly appreciated from the following detailed description when taken in conjunction with the accompanying drawings. 
         FIGS. 1A and 1B  show loco-regional relapse and breast cancer specific survival (BCSS), respectively, for subjects whose tumor samples are classified as Luminal A, with or without radiation therapy. 
         FIGS. 2A and 2B  show loco-regional free survival and BCSS, respectively, for subjects whose tumor samples are classified as Luminal B, with or without radiation therapy. 
         FIGS. 3A and 3B  show loco-regional free survival and BCSS, respectively, for subjects whose tumor samples are classified as HER2-enriched, with or without radiation therapy. 
         FIGS. 4A and 4B  show loco-regional free survival and BCSS, respectively, for subjects whose tumor samples are classified as Basal-like, with or without radiation therapy. 
         FIG. 5  shows 10-year BCSS for subpopulations of Basal-like tumors, with or without radiation therapy. 
         FIGS. 6A and 6B  show loco-regional free survival and BCSS, respectively, for subjects who are classified as low risk based on their Risk of Recurrence Score (subtypes centroid based), ROR-S, with or without radiation therapy. 
         FIGS. 7A and 7B  show loco-regional free survival and BCSS, respectively, for subjects who are classified as moderate/intermediate risk based on their Risk of Recurrence Score (subtypes centroid based), ROR-S, with or without radiation therapy. 
         FIGS. 8A and 8B  show loco-regional free survival and BCSS, respectively, for subjects who are classified as high risk based on their Risk of Recurrence Score (subtypes centroid based), ROR-S, with or without radiation therapy. 
         FIG. 9  is a schematic of the Breast Cancer Intrinsic Subtyping test. 
         FIG. 10  is a schematic of an algorithm process. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     The present invention provides a method of determining whether a post-mastectomy breast cancer treatment comprising radiation is optimal for administration to a patient suffering from breast cancer. Determining whether a breast cancer patient should receive a treatment including radiation includes classifying the subtype of the breast cancer using a gene expression set. The disclosure also provides a method of treating breast cancer by determining whether a post-mastectomy breast cancer patient should receive a treatment including radiation and then administering the optimal breast cancer treatment to the patient based on that determination. 
     Intrinsic genes are statistically selected to have low variation in expression between biological sample replicates from the same individual and high variation in expression across samples from different individuals. Thus, intrinsic genes are used as classifier genes for breast cancer classification. Although clinical information was not used to derive the breast cancer intrinsic subtypes, this classification has proved to have prognostic significance. Intrinsic gene screening can be used to classify breast cancers into various subtypes. The major intrinsic subtypes of breast cancer are referred to as Luminal A (LumA), Luminal B (LumB), HER2-enriched (Her-2-E), Basal-like, and Normal-like (Perou et al.  Nature,  406(6797):747-52 (2000); Sorlie et al.  PNAS,  98(19):10869-74 (2001)). 
     The PAM50 gene expression assay, as described herein, is able to identify intrinsic subtype from standard formalin fixed paraffin embedded tumor tissue (also see, Parker et al.  J Clin Oncol.,  27(8):1160-7 (2009) and U.S. Patent Application Publication No. 2011/0145176). The methods utilize a supervised algorithm to classify subject samples according to breast cancer intrinsic subtype. This algorithm, referred to herein as the “PAM50 classification model”, is based on the gene expression profile of a defined subset of intrinsic genes that has been identified herein as superior for classifying breast cancer intrinsic subtypes. See, U.S. Patent Application Publication No. 2011/0145176. The subset of genes, along with exemplary primers specific for their detection, is provided in Table 1. The subset of genes, along with exemplary probes specific for their detection, is provided in Table 2. The exemplary primers and target specific probe sequences are merely representative and not meant to limit the invention. The skilled artisan can utilize any primer and/or target sequence-specific probe for detecting any of (or each of) the genes in Table 1. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 PAM50 Intrinsic Gene List 
               
               
                 Table 1 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 REPRESENTATIVE 
                   
                   
                   
                   
               
               
                   
                 GENBANK 
                   
                 SEQ 
                   
                 SEQ 
               
               
                 GENE 
                 ACCESSION 
                   
                 ID 
                   
                 ID 
               
               
                 NAME 
                 NUMBER 
                 FORWARD PRIMER 
                 NO: 
                 REVERSE PRIMER 
                 NO: 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 ACTR3B 
                 NM_020445 
                 AAAGATTCCTGGGA 
                 1 
                 TGGGGCAGTTCTGTA 
                 51 
               
               
                   
                 NM_001040135 
                 CCTGA 
                   
                 TTACTTC 
                   
               
               
                   
               
               
                 ANLN 
                 NM_018685 
                 ACAGCCACTTTCAG 
                 2 
                 CGATGGTTTTGTACA 
                 52 
               
               
                   
                   
                 AAGCAAG 
                   
                 AGATTTCTC 
                   
               
               
                   
               
               
                 BAG1 
                 NM_004323 
                 CTGGAAGAGTTGAA 
                 3 
                 GCAAATCCTTGGGC 
                 53 
               
               
                   
                   
                 TAAAGAGC 
                   
                 AGA 
                   
               
               
                   
               
               
                 BCL2 
                 NM_000633 
                 TACCTGAACCGGCA 
                 4 
                 GCCGTACAGTTCCAC 
                 54 
               
               
                   
                   
                 CCTG 
                   
                 AAAGG 
                   
               
               
                   
               
               
                 BIRC5 
                 NM_001012271 
                 GCACAAAGCCATTC 
                 5 
                 GACGCTTCCTATCAC 
                 55 
               
               
                   
                   
                 TAAGTC 
                   
                 TCTATTC 
                   
               
               
                   
               
               
                 BLVRA 
                 BX647539 
                 GCTGGCTGAGCAGA 
                 6 
                 TTCCTCCATCAAGAG 
                 56 
               
               
                   
                   
                 AAG 
                   
                 TTCAACA 
                   
               
               
                   
               
               
                 CCNB1 
                 NM_031966 
                 CTTTCGCCTGAGCCT 
                 7 
                 GGGCACATCCAGAT 
                 57 
               
               
                   
                   
                 ATTT 
                   
                 GTTT 
                   
               
               
                   
               
               
                 CCNE1 
                 BC035498 
                 GGCCAAAATCGACA 
                 8 
                 GGGTCTGCACAGAC 
                 58 
               
               
                   
                   
                 GGAC 
                   
                 TGCAT 
                   
               
               
                   
               
               
                 CDC20 
                 BG256659 
                 CTGTCTGAGTGCCG 
                 9 
                 TCCTTGTAATGGGGA 
                 59 
               
               
                   
                   
                 TGGAT 
                   
                 GACCA 
                   
               
               
                   
               
               
                 CDC6 
                 NM_001254 
                 GTAAATCACCTTCT 
                 10 
                 ACTTGGGATATGTGA 
                 60 
               
               
                   
                   
                 GAGCCT 
                   
                 ATAAGACC 
                   
               
               
                   
               
               
                 CDCA1 
                 NM_031423 
                 GGAGGCGGAAGAA 
                 11 
                 GGGGAAAGACAAAG 
                 61 
               
               
                   
                   
                 ACCAG 
                   
                 TTTCCA 
                   
               
               
                   
               
               
                 CDH3 
                 BC041846 
                 GACAAGGAGAATCA 
                 12 
                 ACTGTCTGGGTCCAT 
                 62 
               
               
                   
                   
                 AAAGATCAGC 
                   
                 GGCTA 
                   
               
               
                   
               
               
                 CENPF 
                 NM_016343 
                 GTGGCAGCAGATCA 
                 13 
                 GGATTTCGTGGTGGG 
                 63 
               
               
                   
                   
                 CAA 
                   
                 TTC 
                   
               
               
                   
               
               
                 CEP55 
                 AB091343 
                 CCTCACGAATTGCT 
                 14 
                 CCACAGTCTGTGATA 
                 64 
               
               
                   
                   
                 GAACTT 
                   
                 AACGG 
                   
               
               
                   
               
               
                 CXXC5 
                 BC006428 
                 CATGAAATAGTGCA 
                 15 
                 CCATCAACATTCTCT 
                 65 
               
               
                   
                   
                 TAGTTTGCC 
                   
                 TTATGAACG 
                   
               
               
                   
               
               
                 EGFR 
                 NM_005228 
                 ACACAGAATCTATA 
                 16 
                 ATCAACTCCCAAAC 
                 66 
               
               
                   
                   
                 CCCACCAGAGT 
                   
                 GGTCAC 
                   
               
               
                   
               
               
                 ERBB2 
                 NM_001005862 
                 GCTGGCTCTCACAC 
                 17 
                 GCCCTTACACATCGG 
                 67 
               
               
                   
                   
                 TGATAG 
                   
                 AGAAC 
                   
               
               
                   
               
               
                 ESR1 
                 NM_001122742 
                 GCAGGGAGAGGAGT 
                 18 
                 GACTTCAGGGTGCTG 
                 68 
               
               
                   
                   
                 TTGT 
                   
                 GAC 
                   
               
               
                   
               
               
                 EXO1 
                 NM_130398 
                 CCCATCCATGTGAG 
                 19 
                 TGTGAAGCCAGCAA 
                 69 
               
               
                   
                   
                 GAAGTATAA 
                   
                 TATGTATC 
                   
               
               
                   
               
               
                 FGFR4 
                 AB209631 
                 CTTCTTGGACCTTGG 
                 20 
                 TATTGGGAGGCAGG 
                 70 
               
               
                   
                   
                 CG 
                   
                 AGGTTTA 
                   
               
               
                   
               
               
                 FOXA1 
                 NM_004496 
                 GCTACTACGCAGAC 
                 21 
                 CTGAGTTCATGTTGC 
                 71 
               
               
                   
                   
                 ACG 
                   
                 TGACC 
                   
               
               
                   
               
               
                 FOXC1 
                 NM_001453 
                 GATGTTCGAGTCAC 
                 22 
                 GACAGCTACTATTCC 
                 72 
               
               
                   
                   
                 AGAGG 
                   
                 CGTT 
                   
               
               
                   
               
               
                 GPR160 
                 AJ249248 
                 TTCGGCTGGAAGGA 
                 23 
                 TATGTGAGTAAGCTC 
                 73 
               
               
                   
                   
                 ACC 
                   
                 GGAGAC 
                   
               
               
                   
               
               
                 GRB7 
                 NM_005310 
                 CGTGGCAGATGTGA 
                 24 
                 AGTGGGCATCCCGT 
                 74 
               
               
                   
                   
                 ACGA 
                   
                 AGA 
                   
               
               
                   
               
               
                 HSPC150 
                 NM_014176 
                 GGAGATCCGTCAAC 
                 25 
                 AGTGGACATGCGAG 
                 75 
               
               
                 (UBE2T) 
                   
                 TCCAAA 
                   
                 TGGAG 
                   
               
               
                   
               
               
                 KIF2C 
                 NM_006845 
                 TGGGTCGTGTCAGG 
                 26 
                 CACCGCTGGAAACT 
                 76 
               
               
                   
                   
                 AAAC 
                   
                 GAAC 
                   
               
               
                   
               
               
                 KNTC2 
                 NM_006101 
                 CGCAGTCATCCAGA 
                 27 
                 CGTGCACATCCATGA 
                 77 
               
               
                   
                   
                 GATGTG 
                   
                 CCTT 
                   
               
               
                   
               
               
                 KRT14 
                 BC042437 
                 ACTCAGTACAAGAA 
                 28 
                 GAGGAGATGACCTT 
                 78 
               
               
                   
                   
                 AGAACCG 
                   
                 GCC 
                   
               
               
                   
               
               
                 KRT17 
                 AK095281 
                 GTTGGACCAGTCAA 
                 29 
                 GCCATAGCCACTGCC 
                 79 
               
               
                   
                   
                 CATCTCTG 
                   
                 ACT 
                   
               
               
                   
               
               
                 KRT5 
                 M21389 
                 TGTGGCTCATTAGG 
                 30 
                 CTTCGACTGGACTCT 
                 80 
               
               
                   
                   
                 CAAC 
                   
                 GT 
                   
               
               
                   
               
               
                 MAPT 
                 NM_001123066 
                 GACTCCAAGCGCGA 
                 31 
                 CAGACATGTTGGTAT 
                 81 
               
               
                   
                   
                 AAAC 
                   
                 TGCACATT 
                   
               
               
                   
               
               
                 MDM2 
                 M92424 
                 CCACAAAATATTCA 
                 32 
                 AGGCGATCCTGGGA 
                 82 
               
               
                   
                   
                 TGGTTCTTG 
                   
                 AATTAT 
                   
               
               
                   
               
               
                 MELK 
                 NM_014791 
                 CCAGTAGCATTGTC 
                 33 
                 CCCATTTGTCTGTCT 
                 83 
               
               
                   
                   
                 CGAG 
                   
                 TCAC 
                   
               
               
                   
               
               
                 MIA 
                 BG765502 
                 GTCTCTGGTAATGC 
                 34 
                 CTGATGGTTGAGGCT 
                 84 
               
               
                   
                   
                 ACACT 
                   
                 GTT 
                   
               
               
                   
               
               
                 MK167 
                 NM_002417 
                 GTGGAATGCCTGCT 
                 35 
                 CGCACTCCAGCACCT 
                 85 
               
               
                   
                   
                 GACC 
                   
                 AGAC 
                   
               
               
                   
               
               
                 MLPH 
                 NM_024101 
                 AGGGGTGCCCTCTG 
                 36 
                 TCACAGGGTCAAAC 
                 86 
               
               
                   
                   
                 AGAT 
                   
                 TTCCAGT 
                   
               
               
                   
               
               
                 MMP11 
                 NM_005940 
                 CGAGATCGCCAAGA 
                 37 
                 GATGGTAGAGTTCC 
                 87 
               
               
                   
                   
                 TGTT 
                   
                 AGTGATT 
                   
               
               
                   
               
               
                 MYBL2 
                 BX647151 
                 AGGCGAACACACAA 
                 38 
                 TCTGGTCACGCAGG 
                 88 
               
               
                   
                   
                 CGTC 
                   
                 GCAA 
                   
               
               
                   
               
               
                 MYC 
                 NM_002467 
                 AGCCTCGAACAATT 
                 39 
                 ACACAGATGATGGA 
                 89 
               
               
                   
                   
                 GAAGA 
                   
                 GATGTC 
                   
               
               
                   
               
               
                 NAT1 
                 BC013732 
                 ATCGACTGTGTAAA 
                 40 
                 AGTAGCTACATCTCC 
                 90 
               
               
                   
                   
                 CAACTAGAGAAGA 
                   
                 AGGTTCTCTG 
                   
               
               
                   
               
               
                 ORC6L 
                 NM_014321 
                 TTTAAGAGGGCAAA 
                 41 
                 CGGATTTTATCAACG 
                 91 
               
               
                   
                   
                 TGGAAGG 
                   
                 ATGCAG 
                   
               
               
                   
               
               
                 PGR 
                 NM_000926 
                 TGCCGCAGAACTCA 
                 42 
                 CATTTGCCGTCCTTC 
                 92 
               
               
                   
                   
                 CTTG 
                   
                 ATCG 
                   
               
               
                   
               
               
                 PHGDH 
                 AK093306 
                 CCTCAGATGATGCC 
                 43 
                 GCAGGTCAAAACTC 
                 93 
               
               
                   
                   
                 TATCCA 
                   
                 TCAAAG 
                   
               
               
                   
               
               
                 PTTG1 
                 BE904476 
                 CAGCAAGCGATGGC 
                 44 
                 AGCGGGCTTCTGTAA 
                 94 
               
               
                   
                   
                 ATAGT 
                   
                 TCTGA 
                   
               
               
                   
               
               
                 RRM2 
                 AK123010 
                 AATGCCACCGAAGC 
                 45 
                 GCCTCAGATTTCAAC 
                 95 
               
               
                   
                   
                 CTC 
                   
                 TCGT 
                   
               
               
                   
               
               
                 SFRP1 
                 BC036503 
                 TCGAACTGAAGGCT 
                 46 
                 CTGCTGAGAATCAA 
                 96 
               
               
                   
                   
                 ATTTACGAG 
                   
                 AGTGGGA 
                   
               
               
                   
               
               
                 SLC39A6 
                 NM_012319 
                 GTCGAAGCCGCAAT 
                 47 
                 GGAACAAACTGCTC 
                 97 
               
               
                   
                   
                 TAGG 
                   
                 TGCCA 
                   
               
               
                   
               
               
                 TMEM45B 
                 AK098106 
                 CAAACGTGTGTTCT 
                 48 
                 ACAGCTCTTTAGCAT 
                 98 
               
               
                   
                   
                 GGAGG 
                   
                 TTGTGGA 
                   
               
               
                   
               
               
                 TYMS 
                 BQ56428 
                 TGCCCTGTATGATGT 
                 49 
                 GGGACTATCAATGTT 
                 99 
               
               
                   
                   
                 CAGGA 
                   
                 GGGTTCTC 
                   
               
               
                   
               
               
                 UBE2C 
                 BC032677 
                 GTGAGGGGTGTCAG 
                 50 
                 CACACAGTTCACTGC 
                 100 
               
               
                   
                   
                 CTCAGT 
                   
                 TCCACA 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Exemplary Probes for detecting NANO46 genes 
               
               
                 Table 2 
               
            
           
           
               
               
               
               
            
               
                   
                   
                   
                 SEQ 
               
               
                   
                   
                   
                 ID 
               
               
                 Gene Name 
                 Ref Seq Accession 
                 Target Sequence 
                 NO: 
               
               
                   
               
               
                 ACTR3B 
                 NM_001040135.1 
                 CCAGAAGAAGTTTGTTATAGACGTTGGTTACGAA 
                 101 
               
               
                   
                   
                 AGATTCCTGGGACCTGAAATATTCTTTCACCCGGA 
                   
               
               
                   
                   
                 GTTTGCCAACCCAGACTTTATGGAGTCCATC 
                   
               
               
                   
               
               
                 ANLN 
                 NM_018685.2 
                 CGTGCCAGGCGAGAGAATCTTCAGAGAAAAATGG 
                 102 
               
               
                   
                   
                 CTGAGAGGCCCACAGCAGCTCCAAGGTCTATGAC 
                   
               
               
                   
                   
                 TCATGCTAAGCGAGCTAGACAGCCACTTTCAG 
                   
               
               
                   
               
               
                 BAG1 
                 NM_004323.3 
                 CTTCATGTTACCTCCCAGCAGGGCAGCAGTGAAC 
                 103 
               
               
                   
                   
                 CAGTTGTCCAAGACCTGGCCCAGGTTGTTGAAGA 
                   
               
               
                   
                   
                 GGTCATAGGGGTTCCACAGTCTTTTCAGAAAC 
                   
               
               
                   
               
               
                 BCL2 
                 NM_000633.2 
                 CCAAGCACCGCTTCGTGTGGCTCCACCTGGATGTT 
                 104 
               
               
                   
                   
                 CTGTGCCTGTAAACATAGATTCGCTTTCCATGTTG 
                   
               
               
                   
                   
                 TTGGCCGGATCACCATCTGAAGAGCAGACG 
                   
               
               
                   
               
               
                 BLVRA 
                 NM_000712.3 
                 TTCCTGAAAAAAGAAGTGGTGGGGAAAGACCTGC 
                 105 
               
               
                   
                   
                 TGAAAGGGTCGCTCCTCTTCACAGCTGGCCCGTTG 
                   
               
               
                   
                   
                 GAAGAAGAGCGGTTTGGCTTCCCTGCATTCA 
                   
               
               
                   
               
               
                 CCNE1 
                 NM_001238.1 
                 GAGAACTGTGTCAAGTGGATGGTTCCATTTGCCA 
                 106 
               
               
                   
                   
                 TGGTTATAAGGGAGACGGGGAGCTCAAAACTGAA 
                   
               
               
                   
                   
                 GCACTTCAGGGGCGTCGCTGATGAAGATGCAC 
                   
               
               
                   
               
               
                 CDC20 
                 NM_001255.1 
                 CCCGAGTGGGCTCCCTAAGCTGGAACAGCTATAT 
                 107 
               
               
                   
                   
                 CCTGTCCAGTGGTTCACGTTCTGGCCACATCCACC 
                   
               
               
                   
                   
                 ACCATGATGTTCGGGTAGCAGAACACCATGT 
                   
               
               
                   
               
               
                 CDC6 
                 NM_001254.3 
                 GGGGAAGTTATATGAAGCCTACAGTAAAGTCTGT 
                 108 
               
               
                   
                   
                 CGCAAACAGCAGGTGGCGGCTGTGGACCAGTCAG 
                   
               
               
                   
                   
                 AGTGTTTGTCACTTTCAGGGCTCTTGGAAGCC 
                   
               
               
                   
               
               
                 CDCA1 
                 NM_145697.1 
                 GCCTGGCGGTGTTTTCGTCGTGCTCAGCGGTGGG 
                 109 
               
               
                   
                   
                 AGGAGGCGGAAGAAACCAGAGCCTGGGAGATTA 
                   
               
               
                   
                   
                 ACAGGAAACTTCCAAGATGGAAACTTTGTCTTT 
                   
               
               
                   
               
               
                 CDH3 
                 NM_001793.3 
                 CCCTCGACCGTGAGGATGAGCAGTTTGTGAGGAA 
                 110 
               
               
                   
                   
                 CAACATCTATGAAGTCATGGTCTTGGCCATGGAC 
                   
               
               
                   
                   
                 AATGGAAGCCCTCCCACCACTGGCACGGGAAC 
                   
               
               
                   
               
               
                 CENPF 
                 NM_016343.3 
                 AGAAAATCTTGCAGAGTCCTCCAAACCAACAGCT 
                 111 
               
               
                   
                   
                 GGTGGCAGCAGATCACAAAAGGTCAAAGTTGCTC 
                   
               
               
                   
                   
                 AGCGGAGCCCAGTAGATTCAGGCACCATCCTC 
                   
               
               
                   
               
               
                 CEP55 
                 NM_018131.3 
                 GTACTACCGCATTGCTTGAACAGCTGGAAGAGAC 
                 112 
               
               
                   
                   
                 AACGAGAGAAGGAGAAAGGAGGGAGCAGGTGTT 
                   
               
               
                   
                   
                 GAAAGCCTTATCTGAAGAGAAAGACGTATTGAA 
                   
               
               
                   
               
               
                 CXXC5 
                 NM_016463.5 
                 AGCTGCCCTCTCCGTGCAATGTCACTGCTCGTGTG 
                 113 
               
               
                   
                   
                 GTCTCCAGCAAGGGATTCGGGCGAAGACAAACGG 
                   
               
               
                   
                   
                 ATGCACCCGTCTTTAGAACCAAAAATATTCT 
                   
               
               
                   
               
               
                 EGFR 
                 NM_005228.3 
                 GCAGCCAGGAACGTACTGGTGAAAACACCGCAGC 
                 114 
               
               
                   
                   
                 ATGTCAAGATCACAGATTTTGGGCTGGCCAAACT 
                   
               
               
                   
                   
                 GCTGGGTGCGGAAGAGAAAGAATACCATGCAG 
                   
               
               
                   
               
               
                 ERBB2 
                 NM_004448.2 
                 TGAAGGTGCTTGGATCTGGCGCTTTTGGCACAGTC 
                 115 
               
               
                   
                   
                 TACAAGGGCATCTGGATCCCTGATGGGGAGAATG 
                   
               
               
                   
                   
                 TGAAAATTCCAGTGGCCATCAAAGTGTTGAG 
                   
               
               
                   
               
               
                 ESR1 
                 NM_000125.2 
                 AGGAACCAGGGAAAATGTGTAGAGGGCATGGTG 
                 116 
               
               
                   
                   
                 GAGATCTTCGACATGCTGCTGGCTACATCATCTCG 
                   
               
               
                   
                   
                 GTTCCGCATGATGAATCTGCAGGGAGAGGAGT 
                   
               
               
                   
               
               
                 EXO1 
                 NM_006027.3 
                 TGGCCCACAAAGTAATTAAAGCTGCCCGGTCTCA 
                 117 
               
               
                   
                   
                 GGGGGTAGATTGCCTCGTGGCTCCCTATGAAGCT 
                   
               
               
                   
                   
                 GATGCGCAGTTGGCCTATCTTAACAAAGCGGG 
                   
               
               
                   
               
               
                 FGFR4 
                 NM_002011.3 
                 CCCACATCCAGTGGCTGAAGCACATCGTCATCAA 
                 118 
               
               
                   
                   
                 CGGCAGCAGCTTCGGAGCCGACGGTTTCCCCTAT 
                   
               
               
                   
                   
                 GTGCAAGTCCTAAAGACTGCAGACATCAATAG 
                   
               
               
                   
               
               
                 FOXA1 
                 NM_004496.2 
                 TGGATGGTTGTATTGGGCAGGGTGGCTCCAGGAT 
                 119 
               
               
                   
                   
                 GTTAGGAACTGTGAAGATGGAAGGGCATGAAACC 
                   
               
               
                   
                   
                 AGCGACTGGAACAGCTACTACGCAGACACGCA 
                   
               
               
                   
               
               
                 FOXC1 
                 NM_001453.1 
                 TTCGAGTCACAGAGGATCGGCTTGAACAACTCTC 
                 120 
               
               
                   
                   
                 CAGTGAACGGGAATAGTAGCTGTCAAATGGCCTT 
                   
               
               
                   
                   
                 CCCTTCCAGCCAGTCTCTGTACCGCACGTCCG 
                   
               
               
                   
               
               
                 GPR160 
                 NM_014373.1 
                 GGATTTCAGTCCTTGCTTATGTTTTGGGAGACCCA 
                 121 
               
               
                   
                   
                 GCCATCTACCAAAGCCTGAAGGCACAGAATGCTT 
                   
               
               
                   
                   
                 ATTCTCGTCACTGTCCTTTCTATGTCAGCAT 
                   
               
               
                   
               
               
                 UBE2T 
                 NM_014176.1 
                 GTGTCAGCTCAGTGCATCCCAGGCAGCTCTTAGT 
                 122 
               
               
                   
                   
                 GTGGAGCAGTGAACTGTGTGTGGTTCCTTCTACTT 
                   
               
               
                   
                   
                 GGGGATCATGCAGAGAGCTTCACGTCTGAAG 
                   
               
               
                   
               
               
                 KIF2C 
                 NM_006845.2 
                 GTTGTCTACAGGTTCACAGCAAGGCCACTGGTAC 
                 123 
               
               
                   
                   
                 AGACAATCTTTGAAGGTGGAAAAGCAACTTGTTT 
                   
               
               
                   
                   
                 TGCATATGGCCAGACAGGAAGTGGCAAGACAC 
                   
               
               
                   
               
               
                 KNTC2 
                 NM_006101.1 
                 AAAAGGTCATAAGCATGAAGCGCAGTTCAGTTTC 
                 124 
               
               
                   
                   
                 CAGCGGTGGTGCTGGCCGCCTCTCCATGCAGGAG 
                   
               
               
                   
                   
                 TTAAGATCCCAGGATGTAAATAAACAAGGCCT 
                   
               
               
                   
               
               
                 KRT14 
                 NM_000526.3 
                 GCAGTCATCCAGAGATGTGACCTCCTCCAGCCGC 
                 125 
               
               
                   
                   
                 CAAATCCGCACCAAGGTCATGGATGTGCACGATG 
                   
               
               
                   
                   
                 GCAAGGTGGTGTCCACCCACGAGCAGGTCCTT 
                   
               
               
                   
               
               
                 KRT17 
                 NM_000422.1 
                 CTGACTCAGTACAAGAAAGAACCGGTGACCACCC 
                 126 
               
               
                   
                   
                 GTCAGGTGCGTACCATTGTGGAAGAGGTCCAGGA 
                   
               
               
                   
                   
                 TGGCAAGGTCATCTCCTCCCGCGAGCAGGTCC 
                   
               
               
                   
               
               
                 KRT5 
                 NM_000424.2 
                 CTGGTTCTCTTGCTCCACCAGGAACAAGCCACCAT 
                 127 
               
               
                   
                   
                 GTCTCGCCAGTCAAGTGTGTCCTTCCGGAGCGGG 
                   
               
               
                   
                   
                 GGCAGTCGTAGCTTCAGCACCGCCTCTGCCA 
                   
               
               
                   
               
               
                 MAPT 
                 NM_016835.3 
                 GCCGGGTCCCTCAACTCAAAGCTCGCATGGTCAG 
                 128 
               
               
                   
                   
                 TAAAAGCAAAGACGGGACTGGAAGCGATGACAA 
                   
               
               
                   
                   
                 AAAAGCCAAGACATCCACACGTTCCTCTGCTAA 
                   
               
               
                   
               
               
                 MDM2 
                 NM_006878.2 
                 GGTGAGGAGCAGGCAAATGTGCAATACCAACATG 
                 129 
               
               
                   
                   
                 TCTGTACCTACTGATGGTGCTGTAACCACCTCACA 
                   
               
               
                   
                   
                 GATTCCAGCTTCGGAACAAGAGACCCTGGTT 
                   
               
               
                   
               
               
                 MELK 
                 NM_014791.2 
                 AGAGACAGCCAACAAAATATTCATGGTTCTTGAG 
                 130 
               
               
                   
                   
                 TACTGCCCTGGAGGAGAGCTGTTTGACTATATAA 
                   
               
               
                   
                   
                 TTTCCCAGGATCGCCTGTCAGAAGAGGAGACC 
                   
               
               
                   
               
               
                 MIA 
                 NM_006533.1 
                 CCGGGGCCAAGTGGTGTATGTCTTCTCCAAGCTG 
                 131 
               
               
                   
                   
                 AAGGGCCGTGGGCGGCTCTTCTGGGGAGGCAGCG 
                   
               
               
                   
                   
                 TTCAGGGAGATTACTATGGAGATCTGGCTGCT 
                   
               
               
                   
               
               
                 MKI67 
                 NM_002417.2 
                 GCTTCCAGCAGCAAATCTCAGACAGAGGTTCCTA 
                 132 
               
               
                   
                   
                 AGAGAGGAGGAGAAAGAGTGGCAACCTGCCTTC 
                   
               
               
                   
                   
                 AAAAGAGAGTGTCTATCAGCCGAAGTCAACATG 
                   
               
               
                   
               
               
                 MLPH 
                 NM_024101.4 
                 GAGGAAGTCAAACCTCCCGATATTTCTCCCTCGA 
                 133 
               
               
                   
                   
                 GTGGCTGGGAAACTTGGCAAGAGACCAGAGGAC 
                   
               
               
                   
                   
                 CCAAATGCAGACCCTTCAAGTGAGGCCAAGGCA 
                   
               
               
                   
               
               
                 MMP11 
                 NM_005940.3 
                 AGCAGCCAAGGCCCTGATGTCCGCCTTCTACACC 
                 134 
               
               
                   
                   
                 TTTCGCTACCCACTGAGTCTCAGCCCAGATGACTG 
                   
               
               
                   
                   
                 CAGGGGCGTTCAACACCTATATGGCCAGCCC 
                   
               
               
                   
               
               
                 MYC 
                 NM_002467.3 
                 CACCGAGGAGAATGTCAAGAGGCGAACACACAA 
                 135 
               
               
                   
                   
                 CGTCTTGGAGCGCCAGAGGAGGAACGAGCTAAA 
                   
               
               
                   
                   
                 ACGGAGCTTTTTTGCCCTGCGTGACCAGATCCCG 
                   
               
               
                   
               
               
                 NAT1 
                 NM_000662.4 
                 AGCACTTCCTCATAGACCTTGGATGTGGGAGGAT 
                 136 
               
               
                   
                   
                 TGCATTCAGTCTAGTTCCTGGTTGCCGGCTGAAAT 
                   
               
               
                   
                   
                 AACCTGAATTCAAGCCAGGAAGAAGCAGCAA 
                   
               
               
                   
               
               
                 ORC6L 
                 NM_014321.2 
                 GACTGTGTAAACAACTAGAGAAGATTGGACAGCA 
                 137 
               
               
                   
                   
                 GGTCGACAGAGAACCTGGAGATGTAGCTACTCCA 
                   
               
               
                   
                   
                 CCACGGAAGAGAAAGAAGATAGTGGTTGAAGC 
                   
               
               
                   
               
               
                 PGR 
                 NM_000926.2 
                 GGGATGAAGCATCAGGCTGTCATTATGGTGTCCT 
                 138 
               
               
                   
                   
                 TACCTGTGGGAGCTGTAAGGTCTTCTTTAAGAGG 
                   
               
               
                   
                   
                 GCAATGGAAGGGCAGCACAACTACTTATGTGC 
                   
               
               
                   
               
               
                 PHGDH 
                 NM_006623.2 
                 GCGACGGCTTCGATGAAGGACGGCAAATGGGAG 
                 139 
               
               
                   
                   
                 CGGAAGAAGTTCATGGGAACAGAGCTGAATGGA 
                   
               
               
                   
                   
                 AAGACCCTGGGAATTCTTGGCCTGGGCAGGATTG 
                   
               
               
                   
               
               
                 PTTG1 
                 NM_004219.2 
                 CACCAGCCTTACCTAAAGCTACTAGAAAGGCTTT 
                 140 
               
               
                   
                   
                 GGGAACTGTCAACAGAGCTACAGAAAAGTCTGTA 
                   
               
               
                   
                   
                 AAGACCAAGGGACCCCTCAAACAAAAACAGCC 
                   
               
               
                   
               
               
                 RRM2 
                 NM_001034.1 
                 TTCCTTTTGGACCGCCGAGGAGGTTGACCTCTCCA 
                 141 
               
               
                   
                   
                 AGGACATTCAGCACTGGGAATCCCTGAAACCCGA 
                   
               
               
                   
                   
                 GGAGAGATATTTTATATCCCATGTTCTGGCT 
                   
               
               
                   
               
               
                 SFRP1 
                 NM_003012.3 
                 GTGGGTCACACACACGCACTGCGCCTGTCAGTAG 
                 142 
               
               
                   
                   
                 TGGACATTGTAATCCAGTCGGCTTGTTCTTGCAGC 
                   
               
               
                   
                   
                 ATTCCCGCTCCCTTCCCTCCATAGCCACGCT 
                   
               
               
                   
               
               
                 SLC39A6 
                 NM_012319.2 
                 GATCGAACTGAAGGCTATTTACGAGCAGACTCAC 
                 143 
               
               
                   
                   
                 AAGAGCCCTCCCACTTTGATTCTCAGCAGCCTGCA 
                   
               
               
                   
                   
                 GTCTTGGAAGAAGAAGAGGTCATGATAGCTC 
                   
               
               
                   
               
               
                 TMEM45B 
                 NM_138788.3 
                 CTGGCTGCCCTCAGCATTGTGGCCGTCAACTATTC 
                 144 
               
               
                   
                   
                 TCTTGTTTACTGCCTTTTGACTCGGATGAAGAGAC 
                   
               
               
                   
                   
                 ACGGAAGGGGAGAAATCATTGGAATTCAGA 
                   
               
               
                   
               
               
                 TYMS 
                 NM_001071.1 
                 TGCTAAAGAGCTGTCTTCCAAGGGAGTGAAAATC 
                 145 
               
               
                   
                   
                 TGGGATGCCAATGGATCCCGAGACTTTTTGGACA 
                   
               
               
                   
                   
                 GCCTGGGATTCTCCACCAGAGAAGAAGGGGAC 
                   
               
               
                   
               
               
                 UBE2C 
                 NM_007019.2 
                 GTCTGCCCTGTATGATGTCAGGACCATTCTGCTCT 
                 146 
               
               
                   
                   
                 CCATCCAGAGCCTTCTAGGAGAACCCAACATTGA 
                   
               
               
                   
                   
                 TAGTCCCTTGAACACACATGCTGCCGAGCTC 
               
               
                   
               
            
           
         
       
     
     Table 3 provides select sequences for the PAM50 genes of Table 1. 
     
       
         
           
               
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 GENBANK 
                   
                   
               
               
                 ACCESSION 
                   
                 SEQ 
               
               
                 NUMBER 
                 SEQUENCE 
                 ID NO: 
               
               
                   
               
             
            
               
                 NM_020445 
                 CAGCGGCGCTGCGGCGGCTCGCGGGAGACGCTGCGCGCGGGGCTAGCG 
                 147 
               
               
                   
                 GGCGGCGGAGCGGACGGCGACGGGGCGCTCTCGGGCTGCCGGCGGGGC 
                   
               
               
                   
                 CGAGCGCCGCGCGTCCCGAGCATGGCAGGCTCCCTGCCTCCCTGCGTGG 
                   
               
               
                   
                 TGGACTGTGGCACCGGGTATACCAAGCTTGGCTACGCAGGCAACACTG 
                   
               
               
                   
                 AGCCCCAGTTCATTATTCCTTCATGTATTGCCATCAGAGAGTCAGCAAA 
                   
               
               
                   
                 GGTAGTTGACCAAGCTCAAAGGAGAGTGTTGAGGGGAGTTGATGACCT 
                   
               
               
                   
                 TGACTTTTTCATAGGAGATGAAGCCATCGATAAACCTACATATGCTACA 
                   
               
               
                   
                 AAGTGGCCGATACGACATGGAATCATTGAAGACTGGGATCTTATGGAA 
                   
               
               
                   
                 AGGTTCATGGAGCAAGTGGTTTTTAAATATCTTCGAGCTGAACCTGAGG 
                   
               
               
                   
                 ACCATTATTTTTTAATGACAGAACCTCCACTCAATACACCAGAAAACAG 
                   
               
               
                   
                 AGAGTATCTTGCAGAAATTATGTTTGAATCATTTAACGTACCAGGACTC 
                   
               
               
                   
                 TACATTGCAGTTCAGGCAGTGCTGGCCTTGGCGGCATCTTGGACATCTC 
                   
               
               
                   
                 GACAAGTGGGTGAACGTACGTTAACGGGGATAGTCATTGACAGCGGAG 
                   
               
               
                   
                 ATGGAGTCACCCATGTTATCCCAGTGGCAGAAGGTTATGTAATTGGAAG 
                   
               
               
                   
                 CTGCATCAAACACATCCCGATTGCAGGTAGAGATATTACGTATTTCATT 
                   
               
               
                   
                 CAACAGCTGCTAAGGGAGAGGGAGGTGGGAATCCCTCCTGAGCAGTCA 
                   
               
               
                   
                 CTGGAGACCGCAAAAGCCATTAAGGAGAAATACTGTTACATTTGCCCC 
                   
               
               
                   
                 GATATAGTCAAGGAATTTGCCAAGTATGATGTGGATCCCCGGAAGTGG 
                   
               
               
                   
                 ATCAAACAGTACACGGGTATCAATGCGATCAACCAGAAGAAGTTTGTT 
                   
               
               
                   
                 ATAGACGTTGGTTACGAAAGATTCCTGGGACCTGAAATATTCTTTCACC 
                   
               
               
                   
                 CGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGA 
                   
               
               
                   
                 TGAAGTAATACAGAACTGCCCCATCGATGTGCGGCGCCCGCTGTATAAG 
                   
               
               
                   
                 AATGTCGTACTCTCAGGAGGCTCCACCATGTTCAGGGATTTCGGACGCC 
                   
               
               
                   
                 GACTGCAGAGGGATTTGAAGAGAGTGGTGGATGCTAGGCTGAGGCTCA 
                   
               
               
                   
                 GCGAGGAGCTCAGCGGCGGGAGGATCAAGCCGAAGCCTGTGGAGGTCC 
                   
               
               
                   
                 AGGTGGTCACGCATCACATGCAGCGCTACGCCGTGTGGTTCGGAGGCTC 
                   
               
               
                   
                 CATGCTGGCCTCGACTCCCGAGTTCTTTCAGGTCTGCCACACCAAGAAG 
                   
               
               
                   
                 GACTATGAAGAGTACGGGCCCAGCATCTGCCGCCACAACCCCGTCTTTG 
                   
               
               
                   
                 GAGTCATGTCCTAGTGTCTGCCTGAACGCGTCGTTCGATGGTGTCACGT 
                   
               
               
                   
                 TGGGGAACAAGTGTCCTTCAGAACCCAGAGAAGGCCGCCGTTCTGTAA 
                   
               
               
                   
                 ATAGCGACGTCGGTGTTGCTGCCCAGCAGCGTGCTTGCATTGCCGGTGC 
                   
               
               
                   
                 ATGAGGCGCGGCGCGGGCCCTTCAGTAAAAGCCATTTATCCGTGTGCCG 
                   
               
               
                   
                 ACCGCTGTCTGCCAGCCTCCTCCTTCTCCCGCCCTCCTCACCCTCGCTCT 
                   
               
               
                   
                 CCCTCCTCCTCCTCCTCCGAGCTGCTAGCTGACAAATACAATTCTGAAG 
                   
               
               
                   
                 GAATCCAAATGTGACTTTGAAAATTGTTAGAGAAAACAACATTAGAAA 
                   
               
               
                   
                 ATGGCGCAAAATCGTTAGGTCCCAGGAGAGAATGTGGGGGCGCAAACC 
                   
               
               
                   
                 CTTTTCCTCCCAGCCTATTTTTGTAAATAAAATGTTTAAACTTGAAATAC 
                   
               
               
                   
                 AAATCGATGTTTATATTTCCTATCATTTTGTATTTTATGGTATTTGGTAC 
                   
               
               
                   
                 AACTGGCTGATACTAAGCACGAATAGATATTGATGTTATGGAGTGCTGT 
                   
               
               
                   
                 AATCCAAAGTTTTTAATTGTGAGGCATGTTCTGATATGTTTATAGGCAA 
                   
               
               
                   
                 ACAAATAAAACAGCAAACTTTTTTGCCACATGTTTGCTAGAAAATGATT 
                   
               
               
                   
                 ATACTTTATTGGAGTGACATGAAGTTTGAACACTAAACAGTAATGTATG 
                   
               
               
                   
                 AGAATTACTACAGATACATGTATCTTTTAGTTTTTTTTGTTTGAACTTTC 
                   
               
               
                   
                 TGGAGCTGTTTTATAGAAGATGATGGTTTGTTGTCGGTGAGTGTTGGAT 
                   
               
               
                   
                 GAAATACTTCCTTGCACCATTGTAATAAAAGCTGTTAGAATATTTGTAA 
                   
               
               
                   
                 ATATC 
                   
               
               
                   
               
               
                 NM_001040135 
                 CAGCGGCGCTGCGGCGGCTCGCGGGAGACGCTGCGCGCGGGGCTAGCG 
                 148 
               
               
                   
                 GGCGGCGGAGCGGACGGCGACGGGGCGCTCTCGGGCTGCCGGCGGGGC 
                   
               
               
                   
                 CGAGCGCCGCGCGTCCCGAGCATGGCAGGCTCCCTGCCTCCCTGCGTGG 
                   
               
               
                   
                 TGGACTGTGGCACCGGGTATACCAAGCTTGGCTACGCAGGCAACACTG 
                   
               
               
                   
                 AGCCCCAGTTCATTATTCCTTCATGTATTGCCATCAGAGAGTCAGCAAA 
                   
               
               
                   
                 GGTAGTTGACCAAGCTCAAAGGAGAGTGTTGAGGGGAGTTGATGACCT 
                   
               
               
                   
                 TGACTTTTTCATAGGAGATGAAGCCATCGATAAACCTACATATGCTACA 
                   
               
               
                   
                 AAGTGGCCGATACGACATGGAATCATTGAAGACTGGGATCTTATGGAA 
                   
               
               
                   
                 AGGTTCATGGAGCAAGTGGTTTTTAAATATCTTCGAGCTGAACCTGAGG 
                   
               
               
                   
                 ACCATTATTTTTTAATGACAGAACCTCCACTCAATACACCAGAAAACAG 
                   
               
               
                   
                 AGAGTATCTTGCAGAAATTATGTTTGAATCATTTAACGTACCAGGACTC 
                   
               
               
                   
                 TACATTGCAGTTCAGGCAGTGCTGGCCTTGGCGGCATCTTGGACATCTC 
                   
               
               
                   
                 GACAAGTGGGTGAACGTACGTTAACGGGGATAGTCATTGACAGCGGAG 
                   
               
               
                   
                 ATGGAGTCACCCATGTTATCCCAGTGGCAGAAGGTTATGTAATTGGAAG 
                   
               
               
                   
                 CTGCATCAAACACATCCCGATTGCAGGTAGAGATATTACGTATTTCATT 
                   
               
               
                   
                 CAACAGCTGCTAAGGGAGAGGGAGGTGGGAATCCCTCCTGAGCAGTCA 
                   
               
               
                   
                 CTGGAGACCGCAAAAGCCATTAAGGAGAAATACTGTTACATTTGCCCC 
                   
               
               
                   
                 GATATAGTCAAGGAATTTGCCAAGTATGATGTGGATCCCCGGAAGTGG 
                   
               
               
                   
                 ATCAAACAGTACACGGGTATCAATGCGATCAACCAGAAGAAGTTTGTT 
                   
               
               
                   
                 ATAGACGTTGGTTACGAAAGATTCCTGGGACCTGAAATATTCTTTCACC 
                   
               
               
                   
                 CGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGA 
                   
               
               
                   
                 TGAAGTAATACAGAACTGCCCCATCGATGTGCGGCGCCCGCTGTATAAG 
                   
               
               
                   
                 CCCGAGTTCTTTCAGGTCTGCCACACCAAGAAGGACTATGAAGAGTACG 
                   
               
               
                   
                 GGCCCAGCATCTGCCGCCACAACCCCGTCTTTGGAGTCATGTCCTAGTG 
                   
               
               
                   
                 TCTGCCTGAACGCGTCGTTCGATGGTGTCACGTTGGGGAACAAGTGTCC 
                   
               
               
                   
                 TTCAGAACCCAGAGAAGGCCGCCGTTCTGTAAATAGCGACGTCGGTGTT 
                   
               
               
                   
                 GCTGCCCAGCAGCGTGCTTGCATTGCCGGTGCATGAGGCGCGGCGCGG 
                   
               
               
                   
                 GCCCTTCAGTAAAAGCCATTTATCCGTGTGCCGACCGCTGTCTGCCAGC 
                   
               
               
                   
                 CTCCTCCTTCTCCCGCCCTCCTCACCCTCGCTCTCCCTCCTCCTCCTCCTC 
                   
               
               
                   
                 CGAGCTGCTAGCTGACAAATACAATTCTGAAGGAATCCAAATGTGACTT 
                   
               
               
                   
                 TGAAAATTGTTAGAGAAAACAACATTAGAAAATGGCGCAAAATCGTTA 
                   
               
               
                   
                 GGTCCCAGGAGAGAATGTGGGGGCGCAAACCCTTTTCCTCCCAGCCTAT 
                   
               
               
                   
                 TTTTGTAAATAAAATGTTTAAACTTGAAATACAAATCGATGTTTATATTT 
                   
               
               
                   
                 CCTATCATTTTGTATTTTATGGTATTTGGTACAACTGGCTGATACTAAGC 
                   
               
               
                   
                 ACGAATAGATATTGATGTTATGGAGTGCTGTAATCCAAAGTTTTTAATT 
                   
               
               
                   
                 GTGAGGCATGTTCTGATATGTTTATAGGCAAACAAATAAAACAGCAAA 
                   
               
               
                   
                 CTTTTTTGCCACATGTTTGCTAGAAAATGATTATACTTTATTGGAGTGAC 
                   
               
               
                   
                 ATGAAGTTTGAACACTAAACAGTAATGTATGAGAATTACTACAGATAC 
                   
               
               
                   
                 ATGTATCTTTTAGTTTTTTTTGTTTGAACTTTCTGGAGCTGTTTTATAGAA 
                   
               
               
                   
                 GATGATGGTTTGTTGTCGGTGAGTGTTGGATGAAATACTTCCTTGCACC 
                   
               
               
                   
                 ATTGTAATAAAAGCTGTTAGAATATTTGTAAATATC 
                   
               
               
                   
               
               
                 NM_018685 
                 CTCGGCGCTGAAATTCAAATTTGAACGGCTGCAGAGGCCGAGTCCGTCA 
                 149 
               
               
                   
                 CTGGAAGCCGAGAGGAGAGGACAGCTGGTTGTGGGAGAGTTCCCCCGC 
                   
               
               
                   
                 CTCAGACTCCTGGTTTTTTCCAGGAGACACACTGAGCTGAGACTCACTT 
                   
               
               
                   
                 TTCTCTTCCTGAATTTGAACCACCGTTTCCATCGTCTCGTAGTCCGACGC 
                   
               
               
                   
                 CTGGGGCGATGGATCCGTTTACGGAGAAACTGCTGGAGCGAACCCGTG 
                   
               
               
                   
                 CCAGGCGAGAGAATCTTCAGAGAAAAATGGCTGAGAGGCCCACAGCAG 
                   
               
               
                   
                 CTCCAAGGTCTATGACTCATGCTAAGCGAGCTAGACAGCCACTTTCAGA 
                   
               
               
                   
                 AGCAAGTAACCAGCAGCCCCTCTCTGGTGGTGAAGAGAAATCTTGTAC 
                   
               
               
                   
                 AAAACCATCGCCATCAAAAAAACGCTGTTCTGACAACACTGAAGTAGA 
                   
               
               
                   
                 AGTTTCTAACTTGGAAAATAAACAACCAGTTGAGTCGACATCTGCAAAA 
                   
               
               
                   
                 TCTTGTTCTCCAAGTCCTGTGTCTCCTCAGGTGCAGCCACAAGCAGCAG 
                   
               
               
                   
                 ATACCATCAGTGATTCTGTTGCTGTCCCGGCATCACTGCTGGGCATGAG 
                   
               
               
                   
                 GAGAGGGCTGAACTCAAGATTGGAAGCAACTGCAGCCTCCTCAGTTAA 
                   
               
               
                   
                 AACACGTATGCAAAAACTTGCAGAGCAACGGCGCCGTTGGGATAATGA 
                   
               
               
                   
                 TGATATGACAGATGACATTCCTGAAAGCTCACTCTTCTCACCAATGCCA 
                   
               
               
                   
                 TCAGAGGAAAAGGCTGCTTCCCCTCCCAGACCTCTGCTTTCAAATGCCT 
                   
               
               
                   
                 CGGCAACTCCAGTTGGCAGAAGGGGCCGTCTGGCCAATCTTGCTGCAAC 
                   
               
               
                   
                 TATTTGCTCCTGGGAAGATGATGTAAATCACTCATTTGCAAAACAAAAC 
                   
               
               
                   
                 AGTGTACAAGAACAGCCTGGTACCGCTTGTTTATCCAAATTTTCCTCTG 
                   
               
               
                   
                 CAAGTGGAGCATCTGCTAGGATCAATAGCAGCAGTGTTAAGCAGGAAG 
                   
               
               
                   
                 CTACATTCTGTTCCCAAAGGGATGGCGATGCCTCTTTGAATAAAGCCCT 
                   
               
               
                   
                 ATCCTCAAGTGCTGATGATGCGTCTTTGGTTAATGCCTCAATTTCCAGCT 
                   
               
               
                   
                 CTGTGAAAGCTACTTCTCCAGTGAAATCTACTACATCTATCACTGATGC 
                   
               
               
                   
                 TAAAAGTTGTGAGGGACAAAATCCTGAGCTACTTCCAAAAACTCCTATT 
                   
               
               
                   
                 AGTCCTCTGAAAACGGGGGTATCGAAACCAATTGTGAAGTCAACTTTAT 
                   
               
               
                   
                 CCCAGACAGTTCCATCCAAGGGAGAATTAAGTAGAGAAATTTGTCTGC 
                   
               
               
                   
                 AATCTCAATCTAAAGACAAATCTACGACACCAGGAGGAACAGGAATTA 
                   
               
               
                   
                 AGCCTTTCCTGGAACGCTTTGGAGAGCGTTGTCAAGAACATAGCAAAG 
                   
               
               
                   
                 AAAGTCCAGCTCGTAGCACACCCCACAGAACCCCCATTATTACTCCAAA 
                   
               
               
                   
                 TACAAAGGCCATCCAAGAAAGATTATTCAAGCAAGACACATCTTCATCT 
                   
               
               
                   
                 ACTACCCATTTAGCACAACAGCTCAAGCAGGAACGTCAAAAAGAACTA 
                   
               
               
                   
                 GCATGTCTTCGTGGCCGATTTGACAAGGGCAATATATGGAGTGCAGAA 
                   
               
               
                   
                 AAAGGCGGAAACTCAAAAAGCAAACAACTAGAAACCAAACAGGAAAC 
                   
               
               
                   
                 TCACTGTCAGAGCACTCCCCTCAAAAAACACCAAGGTGTTTCAAAAACT 
                   
               
               
                   
                 CAGTCACTTCCAGTAACAGAAAAGGTGACCGAAAACCAGATACCAGCC 
                   
               
               
                   
                 AAAAATTCTAGTACAGAACCTAAAGGTTTCACTGAATGCGAAATGACG 
                   
               
               
                   
                 AAATCTAGCCCTTTGAAAATAACATTGTTTTTAGAAGAGGACAAATCCT 
                   
               
               
                   
                 TAAAAGTAACATCAGACCCAAAGGTTGAGCAGAAAATTGAAGTGATAC 
                   
               
               
                   
                 GTGAAATTGAGATGAGTGTGGATGATGATGATATCAATAGTTCGAAAG 
                   
               
               
                   
                 TAATTAATGACCTCTTCAGTGATGTCCTAGAGGAAGGTGAACTAGATAT 
                   
               
               
                   
                 GGAGAAGAGCCAAGAGGAGATGGATCAAGCATTAGCAGAAAGCAGCG 
                   
               
               
                   
                 AAGAACAGGAAGATGCACTGAATATCTCCTCAATGTCTTTACTTGCACC 
                   
               
               
                   
                 ATTGGCACAAACAGTTGGTGTGGTAAGTCCAGAGAGTTTAGTGTCCACA 
                   
               
               
                   
                 CCTAGACTGGAATTGAAAGACACCAGCAGAAGTGATGAAAGTCCAAAA 
                   
               
               
                   
                 CCAGGAAAATTCCAAAGAACTCGTGTCCCTCGAGCTGAATCTGGTGATA 
                   
               
               
                   
                 GCCTTGGTTCTGAAGATCGTGATCTTCTTTACAGCATTGATGCATATAG 
                   
               
               
                   
                 ATCTCAAAGATTCAAAGAAACAGAACGTCCATCAATAAAGCAGGTGAT 
                   
               
               
                   
                 TGTTCGGAAGGAAGATGTTACTTCAAAACTGGATGAAAAAAATAATGC 
                   
               
               
                   
                 CTTTCCTTGTCAAGTTAATATCAAACAGAAAATGCAGGAACTCAATAAC 
                   
               
               
                   
                 GAAATAAATATGCAACAGACAGTGATCTATCAAGCTAGCCAGGCTCTT 
                   
               
               
                   
                 AACTGCTGTGTTGATGAAGAACATGGAAAAGGGTCCCTAGAAGAAGCT 
                   
               
               
                   
                 GAAGCAGAAAGACTTCTTCTAATTGCAACTGGGAAGAGAACACTTTTG 
                   
               
               
                   
                 ATTGATGAATTGAATAAATTGAAGAACGAAGGACCTCAGAGGAAGAAT 
                   
               
               
                   
                 AAGGCTAGTCCCCAAAGTGAATTTATGCCATCCAAAGGATCAGTTACTT 
                   
               
               
                   
                 TGTCAGAAATCCGCTTGCCTCTAAAAGCAGATTTTGTCTGCAGTACGGT 
                   
               
               
                   
                 TCAGAAACCAGATGCAGCAAATTACTATTACTTAATTATACTAAAAGCA 
                   
               
               
                   
                 GGAGCTGAAAATATGGTAGCCACACCATTAGCAAGTACTTCAAACTCTC 
                   
               
               
                   
                 TTAACGGTGATGCTCTGACATTCACTACTACATTTACTCTGCAAGATGT 
                   
               
               
                   
                 ATCCAATGACTTTGAAATAAATATTGAAGTTTACAGCTTGGTGCAAAAG 
                   
               
               
                   
                 AAAGATCCCTCAGGCCTTGATAAGAAGAAAAAAACATCCAAGTCCAAG 
                   
               
               
                   
                 GCTATTACTCCAAAGCGACTCCTCACATCTATAACCACAAAAAGCAACA 
                   
               
               
                   
                 TTCATTCTTCAGTCATGGCCAGTCCAGGAGGTCTTAGTGCTGTGCGAAC 
                   
               
               
                   
                 CAGCAACTTCGCCCTTGTTGGATCTTACACATTATCATTGTCTTCAGTAG 
                   
               
               
                   
                 GAAATACTAAGTTTGTTCTGGACAAGGTCCCCTTTTTATCTTCTTTGGAA 
                   
               
               
                   
                 GGTCATATTTATTTAAAAATAAAATGTCAAGTGAATTCCAGTGTTGAAG 
                   
               
               
                   
                 AAAGAGGTTTTCTAACCATATTTGAAGATGTTAGTGGTTTTGGTGCCTG 
                   
               
               
                   
                 GCATCGAAGATGGTGTGTTCTTTCTGGAAACTGTATATCTTATTGGACTT 
                   
               
               
                   
                 ATCCAGATGATGAGAAACGCAAGAATCCCATAGGAAGGATAAATCTGG 
                   
               
               
                   
                 CTAATTGTACCAGTCGTCAGATAGAACCAGCCAACAGAGAATTTTGTGC 
                   
               
               
                   
                 AAGACGCAACACTTTTGAATTAATTACTGTCCGACCACAAAGAGAAGA 
                   
               
               
                   
                 TGACCGAGAGACTCTTGTCAGCCAATGCAGGGACACACTCTGTGTTACC 
                   
               
               
                   
                 AAGAACTGGCTGTCTGCAGATACTAAAGAAGAGCGGGATCTCTGGATG 
                   
               
               
                   
                 CAAAAACTCAATCAAGTTCTTGTTGATATTCGCCTCTGGCAACCTGATG 
                   
               
               
                   
                 CTTGCTACAAACCTATTGGAAAGCCTTAAACCGGGAAATTTCCATGCTA 
                   
               
               
                   
                 TCTAGAGGTTTTTGATGTCATCTTAAGAAACACACTTAAGAGCATCAGA 
                   
               
               
                   
                 TTTACTGATTGCATTTTATGCTTTAAGTACGAAAGGGTTTGTGCCAATAT 
                   
               
               
                   
                 TCACTACGTATTATGCAGTATTTATATCTTTTGTATGTAAAACTTTAACT 
                   
               
               
                   
                 GATTTCTGTCATTCATCAATGAGTAGAAGTAAATACATTATAGTTGATT 
                   
               
               
                   
                 TTGCTAAATCTTAATTTAAAAGCCTCATTTTCCTAGAAATCTAATTATTC 
                   
               
               
                   
                 AGTTATTCATGACAATATTTTTTTAAAAGTAAGAAATTCTGAGTTGTCTT 
                   
               
               
                   
                 CTTGGAGCTGTAGGTCTTGAAGCAGCAACGTCTTTCAGGGGTTGGAGAC 
                   
               
               
                   
                 AGAAACCCATTCTCCAATCTCAGTAGTTTTTTCGAAAGGCTGTGATCAT 
                   
               
               
                   
                 TTATTGATCGTGATATGACTTGTTACTAGGGTACTGAAAAAAATGTCTA 
                   
               
               
                   
                 AGGCCTTTACAGAAACATTTTTAGTAATGAGGATGAGAACTTTTTCAAA 
                   
               
               
                   
                 TAGCAAATATATATTGGCTTAAAGCATGAGGCTGTCTTCAGAAAAGTGA 
                   
               
               
                   
                 TGTGGACATAGGAGGCAATGTGTGAGACTTGGGGGTTCAATATTTTATA 
                   
               
               
                   
                 TAGAAGAGTTAATAAGCACATGGTTTACATTTACTCAGCTACTATATAT 
                   
               
               
                   
                 GCAGTGTGGTGCACATTTTCACAGAATTCTGGCTTCATTAAGATCATTA 
                   
               
               
                   
                 TTTTTGCTGCGTAGCTTACAGACTTAGCATATTAGTTTTTTCTACTCCTA 
                   
               
               
                   
                 CAAGTGTAAATTGAAAAATCTTTATATTAAAAAAGTAAACTGTTATGAA 
                   
               
               
                   
                 GCTGCTATGTACTAATAATACTTTGCTTGCCAAAGTGTTTGGGTTTTGTT 
                   
               
               
                   
                 GTTGTTTGTTTGTTTGTTTGTTTTTGGTTCATGAACAACAGTGTCTAGAA 
                   
               
               
                   
                 ACCCATTTTGAAAGTGGAAAATTATTAAGTCACCTATCACCTTTAAACG 
                   
               
               
                   
                 CCTTTTTTTAAAATTATAAAATATTGTAAAGCAGGGTCTCAACTTTTAAA 
                   
               
               
                   
                 TACACTTTGAACTTCTTCTCTGAATTATTAAAGTTCTTTATGACCTCATT 
                   
               
               
                   
                 TATAAACACTAAATTCTGTCACCTCCTGTCATTTTATTTTTTATTCATTCA 
                   
               
               
                   
                 AATGTATTTTTTCTTGTGCATATTATAAAAATATATTTTATGAGCTCTTA 
                   
               
               
                   
                 CTCAAATAAATACCTGTAAATGTCTAAAGGAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_004323 
                 AGGCCGGGGCGGGGCTGGGAAGTAGTCGGGCGGGGTTGTGAGACGCCG 
                 150 
               
               
                   
                 CGCTCAGCTTCCATCGCTGGGCGGTCAACAAGTGCGGGCCTGGCTCAGC 
                   
               
               
                   
                 GCGGGGGGGCGCGGAGACCGCGAGGCGACCGGGAGCGGCTGGGTTCCC 
                   
               
               
                   
                 GGCTGCGCGCCCTTCGGCCAGGCCGGGAGCCGCGCCAGTCGGAGCCCC 
                   
               
               
                   
                 CGGCCCAGCGTGGTCCGCCTCCCTCTCGGCGTCCACCTGCCCGGAGTAC 
                   
               
               
                   
                 TGCCAGCGGGCATGACCGACCCACCAGGGGCGCCGCCGCCGGCGCTCG 
                   
               
               
                   
                 CAGGCCGCGGATGAAGAAGAAAACCCGGCGCCGCTCGACCCGGAGCGA 
                   
               
               
                   
                 GGAGTTGACCCGGAGCGAGGAGTTGACCCTGAGTGAGGAAGCGACCTG 
                   
               
               
                   
                 GAGTGAAGAGGCGACCCAGAGTGAGGAGGCGACCCAGGGCGAAGAGA 
                   
               
               
                   
                 TGAATCGGAGCCAGGAGGTGACCCGGGACGAGGAGTCGACCCGGAGCG 
                   
               
               
                   
                 AGGAGGTGACCAGGGAGGAAATGGCGGCAGCTGGGCTCACCGTGACTG 
                   
               
               
                   
                 TCACCCACAGCAATGAGAAGCACGACCTTCATGTTACCTCCCAGCAGGG 
                   
               
               
                   
                 CAGCAGTGAACCAGTTGTCCAAGACCTGGCCCAGGTTGTTGAAGAGGT 
                   
               
               
                   
                 CATAGGGGTTCCACAGTCTTTTCAGAAACTCATATTTAAGGGAAAATCT 
                   
               
               
                   
                 CTGAAGGAAATGGAAACACCGTTGTCAGCACTTGGAATACAAGATGGT 
                   
               
               
                   
                 TGCCGGGTCATGTTAATTGGGAAAAAGAACAGTCCACAGGAAGAGGTT 
                   
               
               
                   
                 GAACTAAAGAAGTTGAAACATTTGGAGAAGTCTGTGGAGAAGATAGCT 
                   
               
               
                   
                 GACCAGCTGGAAGAGTTGAATAAAGAGCTTACTGGAATCCAGCAGGGT 
                   
               
               
                   
                 TTTCTGCCCAAGGATTTGCAAGCTGAAGCTCTCTGCAAACTTGATAGGA 
                   
               
               
                   
                 GAGTAAAAGCCACAATAGAGCAGTTTATGAAGATCTTGGAGGAGATTG 
                   
               
               
                   
                 ACACACTGATCCTGCCAGAAAATTTCAAAGACAGTAGATTGAAAAGGA 
                   
               
               
                   
                 AAGGCTTGGTAAAAAAGGTTCAGGCATTCCTAGCCGAGTGTGACACAG 
                   
               
               
                   
                 TGGAGCAGAACATCTGCCAGGAGACTGAGCGGCTGCAGTCTACAAACT 
                   
               
               
                   
                 TTGCCCTGGCCGAGTGAGGTGTAGCAGAAAAAGGCTGTGCTGCCCTGA 
                   
               
               
                   
                 AGAATGGCGCCACCAGCTCTGCCGTCTCTGGAGCGGAATTTACCTGATT 
                   
               
               
                   
                 TCTTCAGGGCTGCTGGGGGCAACTGGCCATTTGCCAATTTTCCTACTCTC 
                   
               
               
                   
                 ACACTGGTTCTCAATGAAAAATAGTGTCTTTGTGATTTTGAGTAAAGCT 
                   
               
               
                   
                 CCTATCTGTTTTCTCCTTCTGTCTCTGTGGTTGTACTGTCCAGCAATCCA 
                   
               
               
                   
                 CCTTTTCTGGAGAGGGCCACCTCTGCCCAAATTTTCCCAGCTGTTTGGAC 
                   
               
               
                   
                 CTCTGGGTGCTTTCTTTGGGCTGGTGAGAGCTCTAATTTGCCTTGGGCCA 
                   
               
               
                   
                 GTTTCAGGTTTATAGGCCCCCTCAGTCTTCAGATACATGAGGGCTTCTTT 
                   
               
               
                   
                 GCTCTTGTGATCGTGTAGTCCCATAGCTGTAAAACCAGAATCACCAGGA 
                   
               
               
                   
                 GGTTGCACCTAGTCAGGAATATTGGGAATGGCCTAGAACAAGGTGTTTG 
                   
               
               
                   
                 GCACATAAGTAGACCACTTATCCCTCATTGTGACCTAATTCCAGAGCAT 
                   
               
               
                   
                 CTGGCTGGGTTGTTGGGTTCTAGACTTTGTCCTCACCTCCCAGTGACCCT 
                   
               
               
                   
                 GACTAGCCACAGGCCATGAGATACCAGGGGGCCGTTCCTTGGATGGAG 
                   
               
               
                   
                 CCTGTGGTTGATGCAAGGCTTCCTTGTCCCCAAGCAAGTCTTCAGAAGG 
                   
               
               
                   
                 TTAGAACCCAGTGTTGACTGAGTCTGTGCTTGAAACCAGGCCAGAGCCA 
                   
               
               
                   
                 TGGATTAGGAAGGGCAAAGAGAAGGCACCAGAATGAGTAAAGCAGGC 
                   
               
               
                   
                 AGGTGGTGAAGCCAACCATAAACTTCTCAGGAGTGACATGTGCTTCCTT 
                   
               
               
                   
                 CAAAGGCATTTTTGTTAACCATATCCTTCTGAGTTCTATGTTTCCTTCAC 
                   
               
               
                   
                 AGCTGTTCTATCCATTTTGTGGACTGTCCCCCACCCCCACCCCATCATTG 
                   
               
               
                   
                 TTTTTAAAAAATTAAGGCCTGGCGCAGCAGCTCATGCCTATAATCCCAG 
                   
               
               
                   
                 CACTTTGGGAGGCTGAGGCGGGCGGATCACTTGAGGCCAGGAGTTTGA 
                   
               
               
                   
                 GACCAGCCCAGGCAACATAGCAAAACCCCATTCTGCTTTAAAAAAAAA 
                   
               
               
                   
                 AAAAAAAAAAATTAGCTTGGCGTAGTGGCATGTGCCTATAATCCCAGCT 
                   
               
               
                   
                 ACTGGGGAGGCTGAGGCACAAGAATCATTTGAACCTGGGAGGTAGAGG 
                   
               
               
                   
                 TTGCTGTGAGCCGAGATTACGCCCCTGCACTCCAGCCTGGGTCACAGAG 
                   
               
               
                   
                 TGAGACTCCATCTCAGAAAAAAAAAAAATTGAGTCAGGTGCAGTAGCT 
                   
               
               
                   
                 CCTTCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCTAGAGGATCACTT 
                   
               
               
                   
                 GAGCCCAGGAGTTTGAGTCTAGTCTGGGCAACATAGCAAGACCCCATCT 
                   
               
               
                   
                 CTAAAATTTAAGTAAGTAAAAGTAGATAAATAAAAAGAAAAAAAAACT 
                   
               
               
                   
                 GTTTATGTGCTCATCATAAAGTAGAAGAGTGGTTTGCTTTTTTTTTTTTT 
                   
               
               
                   
                 TTTGGATTAATGAGGAAATCATTCTGTGGCTCTAGTCATAATTTATGCTT 
                   
               
               
                   
                 AATAACATTGATAGTAGCCCTTTGCGCTATAACTCTACCTAAAGACTCA 
                   
               
               
                   
                 CATCATTTGGCAGAGAGAGAGTCGTTGAAGTCCCAGGAATTCAGGACT 
                   
               
               
                   
                 GGGCAGGTTAAGACCTCAGACAAGGTAGTAGAGGTAGACTTGTGGACA 
                   
               
               
                   
                 AGGCTCGGGTCCCAGCCCACCGCACCCCAACTTTAATCAGAGTGGTTCA 
                   
               
               
                   
                 CTATTGATCTATTTTTGTGTGATAGCTGTGTGGCGTGGGCCACAACATTT 
                   
               
               
                   
                 AATGAGAAGTTACTGTGCACCAAACTGCCGAACACCATTCTAAACTATT 
                   
               
               
                   
                 CATATATATTAGTCATTTAATTCTTACATAACTTGAGAGGTAGACAGAT 
                   
               
               
                   
                 ATCCTTATTTTAGAGATGAGGAAACCAAGAGAACTTAGGTCATTAGCGC 
                   
               
               
                   
                 AAGGTTGTAGAGTAAGCGGCAAAGCCAAGACACAAAGCTGGGTGGTTT 
                   
               
               
                   
                 GGTTTCAGAGCCAGTGCTTTTCCCCTCTACTGTACTGCCTCTCAACCAAC 
                   
               
               
                   
                 ACAGGGTTGCACAGGCCCATTCTCTGATTTTTTTCCTCTTGTCCTCTGCC 
                   
               
               
                   
                 TCTCCCTCTAGCTCCCACTTCCTCTCTGCTCTAGTTCATTTTCTTTAGAGC 
                   
               
               
                   
                 AGCCCGAGTGATCATGAAGTGCAAATCTTGCCATGTCAGTCCCCTGCTT 
                   
               
               
                   
                 AGAACCCTCCAATGGCTCACTTTCTCTTTAGGCAAAAGTCTTTACCCCAT 
                   
               
               
                   
                 GCCTTCTCCCATCTCATCTCAACCCCCTCATTTGTTGGCTGTCTGCTGTC 
                   
               
               
                   
                 AGCCACTCTTCTTTCAGGTCCTCAGATGCACTGCACCCTCTCCTGCCTGG 
                   
               
               
                   
                 GGGTCTTTGCTCCTGCTACTACCTCTGCTTGAACAGCTCCTCACCTTCCT 
                   
               
               
                   
                 TCCTCCAACCCTACCCTTGTATAGGTGACTTTTGTTCATCCTTCAGAATT 
                   
               
               
                   
                 CAACTCACATGTCTCTTGCATGGAGAACCCTCACCTACTGTGTTGAGAC 
                   
               
               
                   
                 CCTGTCCAGCCCCCAGGTGGGATCCTCTCTCGACTTCCCATACATTTCTT 
                   
               
               
                   
                 TCACAGCATTTACATAGTCCATGATAGTTTACTTGTGGGATTATTTGGTT 
                   
               
               
                   
                 AATCTTTGCCTTTAACACCAGGGTTCCTTGGGTGAAGGAGCTTCTTTATC 
                   
               
               
                   
                 TTGGTAACAGCATTATTTCAAGCATAACTTGTAATATAGTTATATTACAT 
                   
               
               
                   
                 ATATAACATATATATATATAACATAACATATATAACATATATAACAAGC 
                   
               
               
                   
                 ATAACTTGTTATATAGTCTTGTATATAGTAAGACCTCAATAAATATTTG 
                   
               
               
                   
                 GAGAACAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_000633 
                 TTTCTGTGAAGCAGAAGTCTGGGAATCGATCTGGAAATCCTCCTAATTT 
                 151 
               
               
                   
                 TTACTCCCTCTCCCCGCGACTCCTGATTCATTGGGAAGTTTCAAATCAGC 
                   
               
               
                   
                 TATAACTGGAGAGTGCTGAAGATTGATGGGATCGTTGCCTTATGCATTT 
                   
               
               
                   
                 GTTTTGGTTTTACAAAAAGGAAACTTGACAGAGGATCATGCTGTACTTA 
                   
               
               
                   
                 AAAAATACAACATCACAGAGGAAGTAGACTGATATTAACAATACTTAC 
                   
               
               
                   
                 TAATAATAACGTGCCTCATGAAATAAAGATCCGAAAGGAATTGGAATA 
                   
               
               
                   
                 AAAATTTCCTGCATCTCATGCCAAGGGGGAAACACCAGAATCAAGTGTT 
                   
               
               
                   
                 CCGCGTGATTGAAGACACCCCCTCGTCCAAGAATGCAAAGCACATCCA 
                   
               
               
                   
                 ATAAAATAGCTGGATTATAACTCCTCTTCTTTCTCTGGGGGCCGTGGGG 
                   
               
               
                   
                 TGGGAGCTGGGGCGAGAGGTGCCGTTGGCCCCCGTTGCTTTTCCTCTGG 
                   
               
               
                   
                 GAAGGATGGCGCACGCTGGGAGAACAGGGTACGATAACCGGGAGATA 
                   
               
               
                   
                 GTGATGAAGTACATCCATTATAAGCTGTCGCAGAGGGGCTACGAGTGG 
                   
               
               
                   
                 GATGCGGGAGATGTGGGCGCCGCGCCCCCGGGGGCCGCCCCCGCACCG 
                   
               
               
                   
                 GGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCCGCATCCC 
                   
               
               
                   
                 GGGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCG 
                   
               
               
                   
                 GCGCCGCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCT 
                   
               
               
                   
                 GACCCTCCGCCAGGCCGGCGACGACTTCTCCCGCCGCTACCGCCGCGAC 
                   
               
               
                   
                 TTCGCCGAGATGTCCAGCCAGCTGCACCTGACGCCCTTCACCGCGCGGG 
                   
               
               
                   
                 GACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGACGGGGTGAACT 
                   
               
               
                   
                 GGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGA 
                   
               
               
                   
                 GAGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTG 
                   
               
               
                   
                 GATGACTGAGTACCTGAACCGGCACCTGCACACCTGGATCCAGGATAA 
                   
               
               
                   
                 CGGAGGCTGGGATGCCTTTGTGGAACTGTACGGCCCCAGCATGCGGCCT 
                   
               
               
                   
                 CTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTGCTCAGTTTGGCCCT 
                   
               
               
                   
                 GGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGGGCCACAAGTGAAGT 
                   
               
               
                   
                 CAACATGCCTGCCCCAAACAAATATGCAAAAGGTTCACTAAAGCAGTA 
                   
               
               
                   
                 GAAATAATATGCATTGTCAGTGATGTACCATGAAACAAAGCTGCAGGC 
                   
               
               
                   
                 TGTTTAAGAAAAAATAACACACATATAAACATCACACACACAGACAGA 
                   
               
               
                   
                 CACACACACACACAACAATTAACAGTCTTCAGGCAAAACGTCGAATCA 
                   
               
               
                   
                 GCTATTTACTGCCAAAGGGAAATATCATTTATTTTTTACATTATTAAGAA 
                   
               
               
                   
                 AAAAAGATTTATTTATTTAAGACAGTCCCATCAAAACTCCTGTCTTTGG 
                   
               
               
                   
                 AAATCCGACCACTAATTGCCAAGCACCGCTTCGTGTGGCTCCACCTGGA 
                   
               
               
                   
                 TGTTCTGTGCCTGTAAACATAGATTCGCTTTCCATGTTGTTGGCCGGATC 
                   
               
               
                   
                 ACCATCTGAAGAGCAGACGGATGGAAAAAGGACCTGATCATTGGGGAA 
                   
               
               
                   
                 GCTGGCTTTCTGGCTGCTGGAGGCTGGGGAGAAGGTGTTCATTCACTTG 
                   
               
               
                   
                 CATTTCTTTGCCCTGGGGGCTGTGATATTAACAGAGGGAGGGTTCCTGT 
                   
               
               
                   
                 GGGGGGAAGTCCATGCCTCCCTGGCCTGAAGAAGAGACTCTTTGCATAT 
                   
               
               
                   
                 GACTCACATGATGCATACCTGGTGGGAGGAAAAGAGTTGGGAACTTCA 
                   
               
               
                   
                 GATGGACCTAGTACCCACTGAGATTTCCACGCCGAAGGACAGCGATGG 
                   
               
               
                   
                 GAAAAATGCCCTTAAATCATAGGAAAGTATTTTTTTAAGCTACCAATTG 
                   
               
               
                   
                 TGCCGAGAAAAGCATTTTAGCAATTTATACAATATCATCCAGTACCTTA 
                   
               
               
                   
                 AGCCCTGATTGTGTATATTCATATATTTTGGATACGCACCCCCCAACTCC 
                   
               
               
                   
                 CAATACTGGCTCTGTCTGAGTAAGAAACAGAATCCTCTGGAACTTGAGG 
                   
               
               
                   
                 AAGTGAACATTTCGGTGACTTCCGCATCAGGAAGGCTAGAGTTACCCAG 
                   
               
               
                   
                 AGCATCAGGCCGCCACAAGTGCCTGCTTTTAGGAGACCGAAGTCCGCA 
                   
               
               
                   
                 GAACCTGCCTGTGTCCCAGCTTGGAGGCCTGGTCCTGGAACTGAGCCGG 
                   
               
               
                   
                 GGCCCTCACTGGCCTCCTCCAGGGATGATCAACAGGGCAGTGTGGTCTC 
                   
               
               
                   
                 CGAATGTCTGGAAGCTGATGGAGCTCAGAATTCCACTGTCAAGAAAGA 
                   
               
               
                   
                 GCAGTAGAGGGGTGTGGCTGGGCCTGTCACCCTGGGGCCCTCCAGGTA 
                   
               
               
                   
                 GGCCCGTTTTCACGTGGAGCATGGGAGCCACGACCCTTCTTAAGACATG 
                   
               
               
                   
                 TATCACTGTAGAGGGAAGGAACAGAGGCCCTGGGCCCTTCCTATCAGA 
                   
               
               
                   
                 AGGACATGGTGAAGGCTGGGAACGTGAGGAGAGGCAATGGCCACGGC 
                   
               
               
                   
                 CCATTTTGGCTGTAGCACATGGCACGTTGGCTGTGTGGCCTTGGCCCAC 
                   
               
               
                   
                 CTGTGAGTTTAAAGCAAGGCTTTAAATGACTTTGGAGAGGGTCACAAAT 
                   
               
               
                   
                 CCTAAAAGAAGCATTGAAGTGAGGTGTCATGGATTAATTGACCCCTGTC 
                   
               
               
                   
                 TATGGAATTACATGTAAAACATTATCTTGTCACTGTAGTTTGGTTTTATT 
                   
               
               
                   
                 TGAAAACCTGACAAAAAAAAAGTTCCAGGTGTGGAATATGGGGGTTAT 
                   
               
               
                   
                 CTGTACATCCTGGGGCATTAAAAAAAAAATCAATGGTGGGGAACTATA 
                   
               
               
                   
                 AAGAAGTAACAAAAGAAGTGACATCTTCAGCAAATAAACTAGGAAATT 
                   
               
               
                   
                 TTTTTTTCTTCCAGTTTAGAATCAGCCTTGAAACATTGATGGAATAACTC 
                   
               
               
                   
                 TGTGGCATTATTGCATTATATACCATTTATCTGTATTAACTTTGGAATGT 
                   
               
               
                   
                 ACTCTGTTCAATGTTTAATGCTGTGGTTGATATTTCGAAAGCTGCTTTAA 
                   
               
               
                   
                 AAAAATACATGCATCTCAGCGTTTTTTTGTTTTTAATTGTATTTAGTTAT 
                   
               
               
                   
                 GGCCTATACACTATTTGTGAGCAAAGGTGATCGTTTTCTGTTTGAGATTT 
                   
               
               
                   
                 TTATCTCTTGATTCTTCAAAAGCATTCTGAGAAGGTGAGATAAGCCCTG 
                   
               
               
                   
                 AGTCTCAGCTACCTAAGAAAAACCTGGATGTCACTGGCCACTGAGGAG 
                   
               
               
                   
                 CTTTGTTTCAACCAAGTCATGTGCATTTCCACGTCAACAGAATTGTTTAT 
                   
               
               
                   
                 TGTGACAGTTATATCTGTTGTCCCTTTGACCTTGTTTCTTGAAGGTTTCC 
                   
               
               
                   
                 TCGTCCCTGGGCAATTCCGCATTTAATTCATGGTATTCAGGATTACATGC 
                   
               
               
                   
                 ATGTTTGGTTAAACCCATGAGATTCATTCAGTTAAAAATCCAGATGGCA 
                   
               
               
                   
                 AATGACCAGCAGATTCAAATCTATGGTGGTTTGACCTTTAGAGAGTTGC 
                   
               
               
                   
                 TTTACGTGGCCTGTTTCAACACAGACCCACCCAGAGCCCTCCTGCCCTC 
                   
               
               
                   
                 CTTCCGCGGGGGCTTTCTCATGGCTGTCCTTCAGGGTCTTCCTGAAATGC 
                   
               
               
                   
                 AGTGGTGCTTACGCTCCACCAAGAAAGCAGGAAACCTGTGGTATGAAG 
                   
               
               
                   
                 CCAGACCTCCCCGGCGGGCCTCAGGGAACAGAATGATCAGACCTTTGA 
                   
               
               
                   
                 ATGATTCTAATTTTTAAGCAAAATATTATTTTATGAAAGGTTTACATTGT 
                   
               
               
                   
                 CAAAGTGATGAATATGGAATATCCAATCCTGTGCTGCTATCCTGCCAAA 
                   
               
               
                   
                 ATCATTTTAATGGAGTCAGTTTGCAGTATGCTCCACGTGGTAAGATCCT 
                   
               
               
                   
                 CCAAGCTGCTTTAGAAGTAACAATGAAGAACGTGGACGTTTTTAATATA 
                   
               
               
                   
                 AAGCCTGTTTTGTCTTTTGTTGTTGTTCAAACGGGATTCACAGAGTATTT 
                   
               
               
                   
                 GAAAAATGTATATATATTAAGAGGTCACGGGGGCTAATTGCTGGCTGG 
                   
               
               
                   
                 CTGCCTTTTGCTGTGGGGTTTTGTTACCTGGTTTTAATAACAGTAAATGT 
                   
               
               
                   
                 GCCCAGCCTCTTGGCCCCAGAACTGTACAGTATTGTGGCTGCACTTGCT 
                   
               
               
                   
                 CTAAGAGTAGTTGATGTTGCATTTTCCTTATTGTTAAAAACATGTTAGA 
                   
               
               
                   
                 AGCAATGAATGTATATAAAAGCCTCAACTAGTCATTTTTTTCTCCTCTTC 
                   
               
               
                   
                 TTTTTTTTCATTATATCTAATTATTTTGCAGTTGGGCAACAGAGAACCAT 
                   
               
               
                   
                 CCCTATTTTGTATTGAAGAGGGATTCACATCTGCATCTTAACTGCTCTTT 
                   
               
               
                   
                 ATGAATGAAAAAACAGTCCTCTGTATGTACTCCTCTTTACACTGGCCAG 
                   
               
               
                   
                 GGTCAGAGTTAAATAGAGTATATGCACTTTCCAAATTGGGGACAAGGG 
                   
               
               
                   
                 CTCTAAAAAAAGCCCCAAAAGGAGAAGAACATCTGAGAACCTCCTCGG 
                   
               
               
                   
                 CCCTCCCAGTCCCTCGCTGCACAAATACTCCGCAAGAGAGGCCAGAATG 
                   
               
               
                   
                 ACAGCTGACAGGGTCTATGGCCATCGGGTCGTCTCCGAAGATTTGGCAG 
                   
               
               
                   
                 GGGCAGAAAACTCTGGCAGGCTTAAGATTTGGAATAAAGTCACAGAAT 
                   
               
               
                   
                 TAAGGAAGCACCTCAATTTAGTTCAAACAAGACGCCAACATTCTCTCCA 
                   
               
               
                   
                 CAGCTCACTTACCTCTCTGTGTTCAGATGTGGCCTTCCATTTATATGTGA 
                   
               
               
                   
                 TCTTTGTTTTATTAGTAAATGCTTATCATCTAAAGATGTAGCTCTGGCCC 
                   
               
               
                   
                 AGTGGGAAAAATTAGGAAGTGATTATAAATCGAGAGGAGTTATAATAA 
                   
               
               
                   
                 TCAAGATTAAATGTAAATAATCAGGGCAATCCCAACACATGTCTAGCTT 
                   
               
               
                   
                 TCACCTCCAGGATCTATTGAGTGAACAGAATTGCAAATAGTCTCTATTT 
                   
               
               
                   
                 GTAATTGAACTTATCCTAAAACAAATAGTTTATAAATGTGAACTTAAAC 
                   
               
               
                   
                 TCTAATTAATTCCAACTGTACTTTTAAGGCAGTGGCTGTTTTTAGACTTT 
                   
               
               
                   
                 CTTATCACTTATAGTTAGTAATGTACACCTACTCTATCAGAGAAAAACA 
                   
               
               
                   
                 GGAAAGGCTCGAAATACAAGCCATTCTAAGGAAATTAGGGAGTCAGTT 
                   
               
               
                   
                 GAAATTCTATTCTGATCTTATTCTGTGGTGTCTTTTGCAGCCCAGACAAA 
                   
               
               
                   
                 TGTGGTTACACACTTTTTAAGAAATACAATTCTACATTGTCAAGCTTATG 
                   
               
               
                   
                 AAGGTTCCAATCAGATCTTTATTGTTATTCAATTTGGATCTTTCAGGGAT 
                   
               
               
                   
                 TTTTTTTTTAAATTATTATGGGACAAAGGACATTTGTTGGAGGGGTGGG 
                   
               
               
                   
                 AGGGAGGAAGAATTTTTAAATGTAAAACATTCCCAAGTTTGGATCAGG 
                   
               
               
                   
                 GAGTTGGAAGTTTTCAGAATAACCAGAACTAAGGGTATGAAGGACCTG 
                   
               
               
                   
                 TATTGGGGTCGATGTGATGCCTCTGCGAAGAACCTTGTGTGACAAATGA 
                   
               
               
                   
                 GAAACATTTTGAAGTTTGTGGTACGACCTTTAGATTCCAGAGACATCAG 
                   
               
               
                   
                 CATGGCTCAAAGTGCAGCTCCGTTTGGCAGTGCAATGGTATAAATTTCA 
                   
               
               
                   
                 AGCTGGATATGTCTAATGGGTATTTAAACAATAAATGTGCAGTTTTAAC 
                   
               
               
                   
                 TAACAGGATATTTAATGACAACCTTCTGGTTGGTAGGGACATCTGTTTC 
                   
               
               
                   
                 TAAATGTTTATTATGTACAATACAGAAAAAAATTTTATAAAATTAAGCA 
                   
               
               
                   
                 ATGTGAAACTGAATTGGAGAGTGATAATACAAGTCCTTTAGTCTTACCC 
                   
               
               
                   
                 AGTGAATCATTCTGTTCCATGTCTTTGGACAACCATGACCTTGGACAAT 
                   
               
               
                   
                 CATGAAATATGCATCTCACTGGATGCAAAGAAAATCAGATGGAGCATG 
                   
               
               
                   
                 AATGGTACTGTACCGGTTCATCTGGACTGCCCCAGAAAAATAACTTCAA 
                   
               
               
                   
                 GCAAACATCCTATCAACAACAAGGTTGTTCTGCATACCAAGCTGAGCAC 
                   
               
               
                   
                 AGAAGATGGGAACACTGGTGGAGGATGGAAAGGCTCGCTCAATCAAGA 
                   
               
               
                   
                 AAATTCTGAGACTATTAATAAATAAGACTGTAGTGTAGATACTGAGTAA 
                   
               
               
                   
                 ATCCATGCACCTAAACCTTTTGGAAAATCTGCCGTGGGCCCTCCAGATA 
                   
               
               
                   
                 GCTCATTTCATTAAGTTTTTCCCTCCAAGGTAGAATTTGCAAGAGTGAC 
                   
               
               
                   
                 AGTGGATTGCATTTCTTTTGGGGAAGCTTTCTTTTGGTGGTTTTGTTTAT 
                   
               
               
                   
                 TATACCTTCTTAAGTTTTCAACCAAGGTTTGCTTTTGTTTTGAGTTACTG 
                   
               
               
                   
                 GGGTTATTTTTGTTTTAAATAAAAATAAGTGTACAATAAGTGTTTTTGTA 
                   
               
               
                   
                 TTGAAAGCTTTTGTTATCAAGATTTTCATACTTTTACCTTCCATGGCTCT 
                   
               
               
                   
                 TTTTAAGATTGATACTTTTAAGAGGTGGCTGATATTCTGCAACACTGTA 
                   
               
               
                   
                 CACATAAAAAATACGGTAAGGATACTTTACATGGTTAAGGTAAAGTAA 
                   
               
               
                   
                 GTCTCCAGTTGGCCACCATTAGCTATAATGGCACTTTGTTTGTGTTGTTG 
                   
               
               
                   
                 GAAAAAGTCACATTGCCATTAAACTTTCCTTGTCTGTCTAGTTAATATTG 
                   
               
               
                   
                 TGAAGAAAAATAAAGTACAGTGTGAGATACTG 
                   
               
               
                   
               
               
                 NM_001012271 
                 CCCAGAAGGCCGCGGGGGGTGGACCGCCTAAGAGGGCGTGCGCTCCCG 
                 152 
               
               
                   
                 ACATGCCCCGCGGCGCGCCATTAACCGCCAGATTTGAATCGCGGGACCC 
                   
               
               
                   
                 GTTGGCAGAGGTGGCGGCGGCGGCATGGGTGCCCCGACGTTGCCCCCT 
                   
               
               
                   
                 GCCTGGCAGCCCTTTCTCAAGGACCACCGCATCTCTACATTCAAGAACT 
                   
               
               
                   
                 GGCCCTTCTTGGAGGGCTGCGCCTGCACCCCGGAGCGGATGGCCGAGG 
                   
               
               
                   
                 CTGGCTTCATCCACTGCCCCACTGAGAACGAGCCAGACTTGGCCCAGTG 
                   
               
               
                   
                 TTTCTTCTGCTTCAAGGAGCTGGAAGGCTGGGAGCCAGATGACGACCCC 
                   
               
               
                   
                 ATTGGGCCGGGCACGGTGGCTTACGCCTGTAATACCAGCACTTTGGGAG 
                   
               
               
                   
                 GCCGAGGCGGGCGGATCACGAGAGAGGAACATAAAAAGCATTCGTCCG 
                   
               
               
                   
                 GTTGCGCTTTCCTTTCTGTCAAGAAGCAGTTTGAAGAATTAACCCTTGGT 
                   
               
               
                   
                 GAATTTTTGAAACTGGACAGAGAAAGAGCCAAGAACAAAATTGCAAAG 
                   
               
               
                   
                 GAAACCAACAATAAGAAGAAAGAATTTGAGGAAACTGCGGAGAAAGT 
                   
               
               
                   
                 GCGCCGTGCCATCGAGCAGCTGGCTGCCATGGATTGAGGCCTCTGGCCG 
                   
               
               
                   
                 GAGCTGCCTGGTCCCAGAGTGGCTGCACCACTTCCAGGGTTTATTCCCT 
                   
               
               
                   
                 GGTGCCACCAGCCTTCCTGTGGGCCCCTTAGCAATGTCTTAGGAAAGGA 
                   
               
               
                   
                 GATCAACATTTTCAAATTAGATGTTTCAACTGTGCTCTTGTTTTGTCTTG 
                   
               
               
                   
                 AAAGTGGCACCAGAGGTGCTTCTGCCTGTGCAGCGGGTGCTGCTGGTAA 
                   
               
               
                   
                 CAGTGGCTGCTTCTCTCTCTCTCTCTCTTTTTTGGGGGCTCATTTTTGCTG 
                   
               
               
                   
                 TTTTGATTCCCGGGCTTACCAGGTGAGAAGTGAGGGAGGAAGAAGGCA 
                   
               
               
                   
                 GTGTCCCTTTTGCTAGAGCTGACAGCTTTGTTCGCGTGGGCAGAGCCTT 
                   
               
               
                   
                 CCACAGTGAATGTGTCTGGACCTCATGTTGTTGAGGCTGTCACAGTCCT 
                   
               
               
                   
                 GAGTGTGGACTTGGCAGGTGCCTGTTGAATCTGAGCTGCAGGTTCCTTA 
                   
               
               
                   
                 TCTGTCACACCTGTGCCTCCTCAGAGGACAGTTTTTTTGTTGTTGTGTTT 
                   
               
               
                   
                 TTTTGTTTTTTTTTTTTTGGTAGATGCATGACTTGTGTGTGATGAGAGAA 
                   
               
               
                   
                 TGGAGACAGAGTCCCTGGCTCCTCTACTGTTTAACAACATGGCTTTCTT 
                   
               
               
                   
                 ATTTTGTTTGAATTGTTAATTCACAGAATAGCACAAACTACAATTAAAA 
                   
               
               
                   
                 CTAAGCACAAAGCCATTCTAAGTCATTGGGGAAACGGGGTGAACTTCA 
                   
               
               
                   
                 GGTGGATGAGGAGACAGAATAGAGTGATAGGAAGCGTCTGGCAGATAC 
                   
               
               
                   
                 TCCTTTTGCCACTGCTGTGTGATTAGACAGGCCCAGTGAGCCGCGGGGC 
                   
               
               
                   
                 ACATGCTGGCCGCTCCTCCCTCAGAAAAAGGCAGTGGCCTAAATCCTTT 
                   
               
               
                   
                 TTAAATGACTTGGCTCGATGCTGTGGGGGACTGGCTGGGCTGCTGCAGG 
                   
               
               
                   
                 CCGTGTGTCTGTCAGCCCAACCTTCACATCTGTCACGTTCTCCACACGG 
                   
               
               
                   
                 GGGAGAGACGCAGTCCGCCCAGGTCCCCGCTTTCTTTGGAGGCAGCAG 
                   
               
               
                   
                 CTCCCGCAGGGCTGAAGTCTGGCGTAAGATGATGGATTTGATTCGCCCT 
                   
               
               
                   
                 CCTCCCTGTCATAGAGCTGCAGGGTGGATTGTTACAGCTTCGCTGGAAA 
                   
               
               
                   
                 CCTCTGGAGGTCATCTCGGCTGTTCCTGAGAAATAAAAAGCCTGTCATT 
                   
               
               
                   
                 TCAAACACTGCTGTGGACCCTACTGGGTTTTTAAAATATTGTCAGTTTTT 
                   
               
               
                   
                 CATCGTCGTCCCTAGCCTGCCAACAGCCATCTGCCCAGACAGCCGCAGT 
                   
               
               
                   
                 GAGGATGAGCGTCCTGGCAGAGACGCAGTTGTCTCTGGGCGCTTGCCA 
                   
               
               
                   
                 GAGCCACGAACCCCAGACCTGTTTGTATCATCCGGGCTCCTTCCGGGCA 
                   
               
               
                   
                 GAAACAACTGAAAATGCACTTCAGACCCACTTATTTCTGCCACATCTGA 
                   
               
               
                   
                 GTCGGCCTGAGATAGACTTTTCCCTCTAAACTGGGAGAATATCACAGTG 
                   
               
               
                   
                 GTTTTTGTTAGCAGAAAATGCACTCCAGCCTCTGTACTCATCTAAGCTG 
                   
               
               
                   
                 CTTATTTTTGATATTTGTGTCAGTCTGTAAATGGATACTTCACTTTAATA 
                   
               
               
                   
                 ACTGTTGCTTAGTAATTGGCTTTGTAGAGAAGCTGGAAAAAAATGGTTT 
                   
               
               
                   
                 TGTCTTCAACTCCTTTGCATGCCAGGCGGTGATGTGGATCTCGGCTTCTG 
                   
               
               
                   
                 TGAGCCTGTGCTGTGGGCAGGGCTGAGCTGGAGCCGCCCCTCTCAGCCC 
                   
               
               
                   
                 GCCTGCCACGGCCTTTCCTTAAAGGCCATCCTTAAAACCAGACCCTCAT 
                   
               
               
                   
                 GGCTACCAGCACCTGAAAGCTTCCTCGACATCTGTTAATAAAGCCGTAG 
                   
               
               
                   
                 GCCCTTGTCTAAGTGCAACCGCCTAGACTTTCTTTCAGATACATGTCCAC 
                   
               
               
                   
                 ATGTCCATTTTTCAGGTTCTCTAAGTTGGAGTGGAGTCTGGGAAGGGTT 
                   
               
               
                   
                 GTGAATGAGGCTTCTGGGCTATGGGTGAGGTTCCAATGGCAGGTTAGA 
                   
               
               
                   
                 GCCCCTCGGGCCAACTGCCATCCTGGAAAGTAGAGACAGCAGTGCCCG 
                   
               
               
                   
                 CTGCCCAGAAGAGACCAGCAAGCCAAACTGGAGCCCCCATTGCAGGCT 
                   
               
               
                   
                 GTCGCCATGTGGAAAGAGTAACTCACAATTGCCAATAAAGTCTCATGTG 
                   
               
               
                   
                 GTTTTATCTAAAAAAAAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 BX647539 
                 AATGAGGGTATTTATAAACTACTTAAATTATAAAAAGAATGAGACATC 
                 153 
               
               
                   
                 AGACTTACAGTTTTGGATACTAATTTTTTTCACTTAACGTTCATTATGTG 
                   
               
               
                   
                 ATAGGAGTTTTCCATCCTATTATACCGCTGTGCGATCTGATCTTGGGCAC 
                   
               
               
                   
                 GTTAACCAACCTCTTGTTGCCTCGATTTTCTCACCTGTAAAAGTGGGGGT 
                   
               
               
                   
                 AATCATAATGCTTACTTAGTAGGATAGCCCTGAAGAATAAGTGACTTAG 
                   
               
               
                   
                 CGAACATAAATAGCTTACAATAGGGTTTTCAGCATGGGAAGGATTCAGT 
                   
               
               
                   
                 AAATGTTAGCTGTCATCATCACCACCTACAAAGGAAGCAATACTGTGCT 
                   
               
               
                   
                 GAAAGTTTTTCCATCATTAATGTAATTTCTATAGTACGATTCCCAAGAA 
                   
               
               
                   
                 GATATTAAAATTATGGAAATAAAGGTATTGGTATATTCCTAATTATTTC 
                   
               
               
                   
                 CTAAAAGATTGTATTGATAAATATGCTCATCCTTCCCTTAACGGGATGC 
                   
               
               
                   
                 ATTCCAGAAAAACAAGTCAAATGTTAGACAAAGTATCAGAAGGGAAAT 
                   
               
               
                   
                 TCTGTAGCCAGAGAGCTAAAAATTACAATAGGGTCTCTAATTATACTTC 
                   
               
               
                   
                 AACTTTTTTAGGAATAATTCTCAGTGTGTTTTCCCACATTTCATATGTAA 
                   
               
               
                   
                 TTTTTTTTTTTTTTTTTTTTTGAGACAGAGCCTCGCCCTGTCACCAGGCTG 
                   
               
               
                   
                 GAGTACAGTGGCGCGATCTCGGCTCACTGCAACTTCCACCTGCTGGGTT 
                   
               
               
                   
                 CAAGCAATTCTTCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAA 
                   
               
               
                   
                 GTGCTGGGATTATAACAGGCGTGGCATGAGTCACCGCGCCCGGCCGAT 
                   
               
               
                   
                 CTTTACTTTTTTATTCTTTGTACCCCCTGCCTATCCAGTTAGCATGTGATT 
                   
               
               
                   
                 AAAGTCAAAGATTTGCCACTTTGGGCCACATCTATTAATTTTCATCTTTG 
                   
               
               
                   
                 TTATAATTGTATTTAGTTTTTGATCTACACTGCTTATTACTCCCAGTCATT 
                   
               
               
                   
                 TTTTATAGAACTGAAAATCTGGTAAAATACTCAAAATTGCACTGACTTC 
                   
               
               
                   
                 TATGTAGAGGCGACACTCCATCAGAACCGTGGGCTGACAGGGAATCCC 
                   
               
               
                   
                 ACTGTGCAGGAGCTGCGCGCATTTTCATTTCTGATTCTCTTTGGCGTATC 
                   
               
               
                   
                 CAGGACTCTGATGACATGATCATATATTTATCAGTAGTAACAGGTTGGG 
                   
               
               
                   
                 CCATTTGTTTTTTGTGGTAAATCATATATTTAAGATTTTAGAAATAAGTT 
                   
               
               
                   
                 GATAGCCATGTATTTTGGAATTTGAAAAAGACATTGCATTACTCAGCTT 
                   
               
               
                   
                 CAAATTAAGCTTTAATCAAATAGTGAAACTTTCCATTAATGGACAGTGT 
                   
               
               
                   
                 ATACCTTTTTGTGTATTTAAAAAAAAAAACACTGAATATAGTGCCTTTG 
                   
               
               
                   
                 TGACAGGGGAGCTTGGTTCCTGACAATGTCCTCTTGAGCCTTTTTTTTTT 
                   
               
               
                   
                 TTTTGAGATGGAGTCTCACTGTGTCACCCAGGCTGGAGTGCAGTGGCGC 
                   
               
               
                   
                 CATCTTGGCTCACTGCAACCTCCGCCCCCTGGGTTCAAGTGATTCTCATT 
                   
               
               
                   
                 CCTCAGCTTCCTAAGTAGCTGGGATTACAGGCACGCACCACCATGACCA 
                   
               
               
                   
                 GCTAATTTTTATACTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCTAGG 
                   
               
               
                   
                 TTGGTCTCGAACTCCTGACCTCAAGTAATCCACCCACCATGGCCTCCCC 
                   
               
               
                   
                 AAAGTGCTGGGATTACAGGCGTGAGCCATTTCACCCGGCCTCTCTTCCG 
                   
               
               
                   
                 TCTTTGAGCTGTGAGGAAATAGCTACATTACATGAGCTGCTAGATCTGC 
                   
               
               
                   
                 CTTATGGTCAGAAATGAAGGTTGAACTCTCAGGAACAGTGACATATATA 
                   
               
               
                   
                 CACACTGATATTTCCAAAGTACAATGCCCCAAATTGATCCACAAAGGAA 
                   
               
               
                   
                 TTAAGGTCATTTGCAACAAAATCACAGAATAGTAACAAATAAATAGAA 
                   
               
               
                   
                 GATAAATATGGCCAGGGATGCTGCAAACTGATATACTGCCAAGTTTATC 
                   
               
               
                   
                 AGTTGGGAATCCCAACAGTGAAAAGCATAAAAATGAAAGGAATTTTAA 
                   
               
               
                   
                 GGAGACTTTTTATAGAAGAGTGGGAAGGATTGGAGGAGCCAACAAGTG 
                   
               
               
                   
                 ATGGTGAGGCACACAGGGAAGAGCTTCAGTGGGCACCATCCCCTCTCT 
                   
               
               
                   
                 GGTTTGAAGGGGTAGGGAGGGGACCAGAGCTGGGAGGAGGGGGCTGG 
                   
               
               
                   
                 AATACTGCTGGAGGAGCCACTCCCTTCCAGACCTGCTGTGGCCATCACA 
                   
               
               
                   
                 GAATGCAGCCACTGCCAGAGCAGCAGCCCGAGGAACCAGGCAGGGGG 
                   
               
               
                   
                 AGCACAAGTACCCTAGCCTCTCTCTTTCTGTTTCTTGCCTGCCGATCTCC 
                   
               
               
                   
                 TCCACTGGCTAAACCCAGCTGGATGCTAAGAGTACAGTCAGCCTGCCTG 
                   
               
               
                   
                 CTGAGGAGGGACCACCAGGGACCACCATCAGCAAGGGATCCAATGTCT 
                   
               
               
                   
                 TTCTGCCTCTGCAGAATGAAGGTTGGGGCGCGGGGGGCGCTCTACTTCT 
                   
               
               
                   
                 TAGGGATATTGTGGGAATAAAAGGAAATAGGCAAAAAATGTTTTTGAA 
                   
               
               
                   
                 AAACAAAGCACATACTGCGCACCCGTGGGCCACTACTGCTTTTGACCCC 
                   
               
               
                   
                 TGGCTCTGTTTCATGAAGTAATGTCGTGTCATTCTCTTTTTAGGTGCTAC 
                   
               
               
                   
                 AGGATTTCTTTAGGTTTGTTTTCTGTCCACCATATTTCAACTCATGTGTG 
                   
               
               
                   
                 CTGTTTGTTGTGCTAAAACAAATATTTGCTGATGCCTGAGTGAATAGTT 
                   
               
               
                   
                 GAATATTTTATATAAGTCAAATTTATACGTAATGATTTTTCTTGTAACTT 
                   
               
               
                   
                 AGCCGTTTCTCTTTTACAAACTCAGAAAACCTCAGACTTTGAAAAGGCC 
                   
               
               
                   
                 TTGAAGTTCCTCACCTGAAATCTGAGAACTTGGAGCGCCTTAAAAAATC 
                   
               
               
                   
                 TAAAGGAAAACAAAACAGTGAAAGAACATGATATAGTCAGTGTAGAGA 
                   
               
               
                   
                 ATAAAATTATTTATGTAATTAATATTGAGGATGCAGATAACACATTGTG 
                   
               
               
                   
                 AAATCTTGCTTGTAAAAAATCTCGATCTGCTGAAGAAAGATGTTCTCTC 
                   
               
               
                   
                 TAGAGATCTTTGAAAGCATAATTATTGAGCTTTTAAAATGTTAGAAACA 
                   
               
               
                   
                 AAAGTTAGACCCACACATATTCTGGCGTGTGGAAGATTTGCATTCCTTC 
                   
               
               
                   
                 CCCTGCCCGCCCCGCCCCCACACTTGTGAGTTGTGCCTGTGTACGCAGT 
                   
               
               
                   
                 TCCTGTAGCACTCGGCTGGGCAGAAATCATCTTTCAGCACTAAGGGAAC 
                   
               
               
                   
                 ATAGTTATGATCTGGACCTTCTGGGAGTGGTCAGTGCCCAAGAACAGGT 
                   
               
               
                   
                 ATGGGACTCCAGAAAGTTCTGCTCTCAACCCTATTTTGAAATAGAGTTA 
                   
               
               
                   
                 CACATTGTTCTACAATTATTTGAGTTAATAAGCAGCTCTTTTCAAACGTG 
                   
               
               
                   
                 ATTATGCCCTTCCAAGTTTAAATACACTAGACTTTAGTGAAAGTAATTG 
                   
               
               
                   
                 ACCTCATCTCATTTCTCTCCTGTTATATTAAGATCACTTTCAGTAAAAGG 
                   
               
               
                   
                 TAGAAGCTTTTGAAGTGGTGAGGAGGAGGTAGAGGAGGGACATAGAGC 
                   
               
               
                   
                 AGATAGGGGCTGGAAAGTGGGGTGAGGAAGAGAGTGGCTTCTCTTTGG 
                   
               
               
                   
                 CAGAGTACCAAGGAAAAGCCCTATCTGTACAGAACCTTTGTGCCTGGG 
                   
               
               
                   
                 AACTTGATGGCTGCAACCTGAGCCTCAACCTAGTTTGCTTGCGGAGCCA 
                   
               
               
                   
                 GAAGAGAAGCTAAAAACCTTCAGTTAACCAAGCCAGACACCAAGAAAG 
                   
               
               
                   
                 TTAAACCGAAAGAGAACCCCCCACCCCCCGCAAAAAAAAGAAGTAAAG 
                   
               
               
                   
                 TGGGTTAAAGTGATATCATGTTAGCACAGAAAGAGAACATAAGGGTCA 
                   
               
               
                   
                 TCTAAGTTCATCTGCCCCCTCTTCTATTTCAAGGTGCAGAAACTAAGGC 
                   
               
               
                   
                 ACAAGGGACCCCGTGTCCTGCTCTTGATCACATAGCTAGTGGGTGCCAA 
                   
               
               
                   
                 GCCAGGTCTAGAACTCTGTTCTCTGGGGTCACAGGCTGGCTCTTCATCC 
                   
               
               
                   
                 CTCTAGAGAGATAGCTCATCTGTGTGCACCTGAGCCCGTTGTGTTTCGG 
                   
               
               
                   
                 AGTCAAAGCAAATAAAGGCTCAAACTCCAAGACTGTTTTGCAGACCGG 
                   
               
               
                   
                 CTGCAGTAGATATGGGGGGAGGAGAAACCTGCTTTAAATTGCTTCAAG 
                   
               
               
                   
                 CAAGTTGTTTCTGCAAAGGTGTTGACTTTTTTCTTTCAACTTTCTAGTGA 
                   
               
               
                   
                 GTCACTGCAGCCTGAGCTGTTATTTGTCATTATGCAATAATTCAGGAAC 
                   
               
               
                   
                 TAACTCAAGATTCTTCTTTTTAAATTATTTGTTTATTTAGAGACAGAGTC 
                   
               
               
                   
                 TTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTG 
                   
               
               
                   
                 CAGCCTCTGCCTCCTGGGTTCAAGCAATTCTCATGTCTCAGCCTCCCGA 
                   
               
               
                   
                 ATAGCTGGTATTGCAGGCTCGTGCCACCACCCCCTGCTAATTTTTGTAAT 
                   
               
               
                   
                 TTTAGTGGAGACACGGTTTCGCCATGTTGGCCGGGCTCGTCTTGAGCTC 
                   
               
               
                   
                 CTGGCCTCAGGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTG 
                   
               
               
                   
                 CAGCCGTGAGCCTCCACACCCGGCCTATTTATTTATTTTTAAATTGGCTG 
                   
               
               
                   
                 CTCTTAGAAAGGCATACCATGTTTCTGGATGGGAAGGCTTATTAATTCA 
                   
               
               
                   
                 CCCTAATTTAATGTATAAATTTGATGCAATCATAGTCACAGTCCCAGTG 
                   
               
               
                   
                 GAATTTTTTAACTTGGTAAGATGTTCTAAAATTAATGAGAGAACTTGAA 
                   
               
               
                   
                 TTACCAGGTATTGAAACACTGTAAAGCCACAATCATGTAAACAGTATGT 
                   
               
               
                   
                 TATAACCATGGGAATAGAGGTCTGTGATACAGCAGAAAAAAGTGAAAA 
                   
               
               
                   
                 AAAGAATAACTGTATTCATAAAAATTTAAATGTGGAGTCACTGGGGGA 
                   
               
               
                   
                 AAGGATTAAATATTCGATAATGTAGAAACAACTCAACTATTTGGAGAA 
                   
               
               
                   
                 ATGTAAATTTAGAGCCTTATCTCATGCCATATACCAAAATACTATTTAG 
                   
               
               
                   
                 ATTTGATTAAAAAATAAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_031966 
                 CGAACGCCTTCGCGCGATCGCCCTGGAAACGCATTCTCTGCGACCGGCA 
                 154 
               
               
                   
                 GCCGCCAATGGGAAGGGAGTGAGTGCCACGAACAGGCCAATAAGGAG 
                   
               
               
                   
                 GGAGCAGTGCGGGGTTTAAATCTGAGGCTAGGCTGGCTCTTCTCGGCGT 
                   
               
               
                   
                 GCTGCGGCGGAACGGCTGTTGGTTTCTGCTGGGTGTAGGTCCTTGGCTG 
                   
               
               
                   
                 GTCGGGCCTCCGGTGTTCTGCTTCTCCCCGCTGAGCTGCTGCCTGGTGA 
                   
               
               
                   
                 AGAGGAAGCCATGGCGCTCCGAGTCACCAGGAACTCGAAAATTAATGC 
                   
               
               
                   
                 TGAAAATAAGGCGAAGATCAACATGGCAGGCGCAAAGCGCGTTCCTAC 
                   
               
               
                   
                 GGCCCCTGCTGCAACCTCCAAGCCCGGACTGAGGCCAAGAACAGCTCTT 
                   
               
               
                   
                 GGGGACATTGGTAACAAAGTCAGTGAACAACTGCAGGCCAAAATGCCT 
                   
               
               
                   
                 ATGAAGAAGGAAGCAAAACCTTCAGCTACTGGAAAAGTCATTGATAAA 
                   
               
               
                   
                 AAACTACCAAAACCTCTTGAAAAGGTACCTATGCTGGTGCCAGTGCCAG 
                   
               
               
                   
                 TGTCTGAGCCAGTGCCAGAGCCAGAACCTGAGCCAGAACCTGAGCCTG 
                   
               
               
                   
                 TTAAAGAAGAAAAACTTTCGCCTGAGCCTATTTTGGTTGATACTGCCTC 
                   
               
               
                   
                 TCCAAGCCCAATGGAAACATCTGGATGTGCCCCTGCAGAAGAAGACCT 
                   
               
               
                   
                 GTGTCAGGCTTTCTCTGATGTAATTCTTGCAGTAAATGATGTGGATGCA 
                   
               
               
                   
                 GAAGATGGAGCTGATCCAAACCTTTGTAGTGAATATGTGAAAGATATTT 
                   
               
               
                   
                 ATGCTTATCTGAGACAACTTGAGGAAGAGCAAGCAGTCAGACCAAAAT 
                   
               
               
                   
                 ACCTACTGGGTCGGGAAGTCACTGGAAACATGAGAGCCATCCTAATTG 
                   
               
               
                   
                 ACTGGCTAGTACAGGTTCAAATGAAATTCAGGTTGTTGCAGGAGACCAT 
                   
               
               
                   
                 GTACATGACTGTCTCCATTATTGATCGGTTCATGCAGAATAATTGTGTG 
                   
               
               
                   
                 CCCAAGAAGATGCTGCAGCTGGTTGGTGTCACTGCCATGTTTATTGCAA 
                   
               
               
                   
                 GCAAATATGAAGAAATGTACCCTCCAGAAATTGGTGACTTTGCTTTTGT 
                   
               
               
                   
                 GACTGACAACACTTATACTAAGCACCAAATCAGACAGATGGAAATGAA 
                   
               
               
                   
                 GATTCTAAGAGCTTTAAACTTTGGTCTGGGTCGGCCTCTACCTTTGCACT 
                   
               
               
                   
                 TCCTTCGGAGAGCATCTAAGATTGGAGAGGTTGATGTCGAGCAACATAC 
                   
               
               
                   
                 TTTGGCCAAATACCTGATGGAACTAACTATGTTGGACTATGACATGGTG 
                   
               
               
                   
                 CACTTTCCTCCTTCTCAAATTGCAGCAGGAGCTTTTTGCTTAGCACTGAA 
                   
               
               
                   
                 AATTCTGGATAATGGTGAATGGACACCAACTCTACAACATTACCTGTCA 
                   
               
               
                   
                 TATACTGAAGAATCTCTTCTTCCAGTTATGCAGCACCTGGCTAAGAATG 
                   
               
               
                   
                 TAGTCATGGTAAATCAAGGACTTACAAAGCACATGACTGTCAAGAACA 
                   
               
               
                   
                 AGTATGCCACATCGAAGCATGCTAAGATCAGCACTCTACCACAGCTGA 
                   
               
               
                   
                 ATTCTGCACTAGTTCAAGATTTAGCCAAGGCTGTGGCAAAGGTGTAACT 
                   
               
               
                   
                 TGTAAACTTGAGTTGGAGTACTATATTTACAAATAAAATTGGCACCATG 
                   
               
               
                   
                 TGCCATCTGTACATATTACTGTTGCATTTACTTTTAATAAAGCTTGTGGC 
                   
               
               
                   
                 CCCTTTTACTTTTTTATAGCTTAACTAATTTGAATGTGGTTACTTCCTACT 
                   
               
               
                   
                 GTAGGGTAGCGGAAAAGTTGTCTTAAAAGGTATGGTGGGGATATTTTTA 
                   
               
               
                   
                 AAAACTCCTTTTGGTTTACCTGGGGATCCAATTGATGTATATGTTTATAT 
                   
               
               
                   
                 ACTGGGTTCTTGTTTTATATACCTGGCTTTTACTTTATTAATATGAGTTA 
                   
               
               
                   
                 CTGAAGGTGATGGAGGTATTTGAAAATTTTACTTCCATAGGACATACTG 
                   
               
               
                   
                 CATGTAAGCCAAGTCATGGAGAATCTGCTGCATAGCTCTATTTTAAAGT 
                   
               
               
                   
                 AAAAGTCTACCACCGAATCCCTAGTCCCCCTGTTTTCTGTTTCTTCTTGT 
                   
               
               
                   
                 GATTGCTGCCATAATTCTAAGTTATTTACTTTTACCACTATTTAAGTTAT 
                   
               
               
                   
                 CAACTTTAGCTAGTATCTTCAAACTTTCACTTTGAAAAATGAGAATTTTA 
                   
               
               
                   
                 TATTCTAAGCCAGTTTTCATTTTGGTTTTGTGTTTTGGTTAATAAAACAA 
                   
               
               
                   
                 TACTCAAATACAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 BC035498 
                 GCGGCCGCCAGCGCGGTGTAGGGGGCAGGCGCGGATCCCGCCACCGCC 
                 155 
               
               
                   
                 GCGCGCTCGGCCCGCCGACTCCCGGCGCCGCCGCCGCCACTGCCGTCGC 
                   
               
               
                   
                 CGCCGCCGCCTGCCGGGACTGGAGCGCGCCGTCCGCCGCGGACAAGAC 
                   
               
               
                   
                 CCTGGCCTCAGGCCGGAGCAGCCCCATCATGCCGAGGGAGCGCAGGGA 
                   
               
               
                   
                 GCGGGATGCGAAGGAGCGGGACACCATGAAGGAGGACGGCGGCGCGG 
                   
               
               
                   
                 AGTTCTCGGCTCGCTCCAGGAAGAGGAAGGCAAACGTGACCGTTTTTTT 
                   
               
               
                   
                 GCAGGATCCAGATGAAGAAATGGCCAAAATCGACAGGACGGCGAGGG 
                   
               
               
                   
                 ACCAGTGTGGGAGCCAGCCTTGGGACAATAATGCAGTCTGTGCAGACC 
                   
               
               
                   
                 CCTGCTCCCTGATCCCCACACCTGACAAAGAAGATGATGACCGGGTTTA 
                   
               
               
                   
                 CCCAAACTCAACGTGCAAGCCTCGGATTATTGCACCATCCAGAGGCTCC 
                   
               
               
                   
                 CCGCTGCCTGTACTGAGCTGGGCAAATAGAGAGGAAGTCTGGAAAATC 
                   
               
               
                   
                 ATGTTAAACAAGGAAAAGACATACTTAAGGGATCAGCACTTTCTTGAG 
                   
               
               
                   
                 CAACACCCTCTTCTGCAGCCAAAAATGCGAGCAATTCTTCTGGATTGGT 
                   
               
               
                   
                 TAATGGAGGTGTGTGAAGTCTATAAACTTCACAGGGAGACCTTTTACTT 
                   
               
               
                   
                 GGCACAAGATTTCTTTGACCGGTATATGGCGACACAAGAAAATGTTGTA 
                   
               
               
                   
                 AAAACTCTTTTACAGCTTATTGGGATTTCATCTTTATTTATTGCAGCCAA 
                   
               
               
                   
                 ACTTGAGGAAATCTATCCTCCAAAGTTGCACCAGTTTGCGTATGTGACA 
                   
               
               
                   
                 GATGGAGCTTGTTCAGGAGATGAAATTCTCACCATGGAATTAATGATTA 
                   
               
               
                   
                 TGAAGGCCCTTAAGTGGCGTTTAAGTCCCCTGACTATTGTGTCCTGGCT 
                   
               
               
                   
                 GAATGTATACATGCAGGTTGCATATCTAAATGACTTACATGAAGTGCTA 
                   
               
               
                   
                 CTGCCGCAGTATCCCCAGCAAATCTTTATACAGATTGCAGAGCTGTTGG 
                   
               
               
                   
                 ATCTCTGTGTCCTGGATGTTGACTGCCTTGAATTTCCTTATGGTATACTT 
                   
               
               
                   
                 GCTGCTTCGGCCTTGTATCATTTCTCGTCATCTGAATTGATGCAAAAGGT 
                   
               
               
                   
                 TTCAGGGTATCAGTGGTGCGACATAGAGAACTGTGTCAAGTGGATGGTT 
                   
               
               
                   
                 CCATTTGCCATGGTTATAAGGGAGACGGGGAGCTCAAAACTGAAGCAC 
                   
               
               
                   
                 TTCAGGGGCGTCGCTGATGAAGATGCACACAACATACAGACCCACAGA 
                   
               
               
                   
                 GACAGCTTGGATTTGCTGGACAAAGCCCGAGCAAAGAAAGCCATGTTG 
                   
               
               
                   
                 TCTGAACAAAATAGGGCTTCTCCTCTCCCCAGTGGGCTCCTCACCCCGC 
                   
               
               
                   
                 CACAGAGCGGTAAGAAGCAGAGCAGCGGGCCGGAAATGGCGTGACCA 
                   
               
               
                   
                 CCCCATCCTTCTCCACCAAAGACAGTTGCGCGCCTGCTCCACGTTCTCTT 
                   
               
               
                   
                 CTGTCTGTTGCAGCGGAGGCGTGCGTTTGCTTTTACAGATATCTGAATG 
                   
               
               
                   
                 GAAGAGTGTTTCTTCCACAACAGAAGTATTTCTGTGGATGGCATCAAAC 
                   
               
               
                   
                 AGGGCAAAGTGTTTTTTATTGAATGCTTATAGGTTTTTTTTAAATAAGTG 
                   
               
               
                   
                 GGTCAAGTACACCAGCCACCTCCAGACACCAGTGCGTGCTCCCGATGCT 
                   
               
               
                   
                 GCTATGGAAGGTGCTACTTGACCTAAGGGACTCCCACAACAACAAAAG 
                   
               
               
                   
                 CTTGAAGCTGTGGAGGGCCACGGTGGCGTGGCTCTCCTCGCAGGTGTTC 
                   
               
               
                   
                 TGGGCTCCGTTGTACCAAGTGGAGCAGGTGGTTGCGGGCAAGCGTTGTG 
                   
               
               
                   
                 CAGAGCCCATAGCCAGCTGGGCAGGGGGCTGCCCTCTCCACATTATCAG 
                   
               
               
                   
                 TTGACAGTGTACAATGCCTTTGATGAACTGTTTTGTAAGTGCTGCTATAT 
                   
               
               
                   
                 CTATCCATTTTTTAATAAAGATAATACTGTTTTTGAAAAAAAAAAAAAA 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
                 AAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 BG256659 
                 GAGGGCACGGGCTCCGTAGGCACCAACTGCAAGGACCCCTCCCCCTGC 
                 156 
               
               
                   
                 GGGCGCTCCCATGGCACAGTTCGCGTTCGAGAGTGACCTGCACTCGCTG 
                   
               
               
                   
                 CTTCAGCTGGATGCACCCATCCCCAATGCACCCCCTGCGCGCTGGCAGC 
                   
               
               
                   
                 GCAAAGCCAAGGAAGCCGCAGGCCCGGCCCCCTCACCCATGCGGGCCG 
                   
               
               
                   
                 CCAACCGATCCCACAGCGCCGGCAGGACTCCGGGCCGAACTCCTGGCA 
                   
               
               
                   
                 AATCCAGTTCCAAGGTTCAGACCACTCCTAGCAAACCTGGCGGTGACCG 
                   
               
               
                   
                 CTATATCCCCCATCGCAGTGCTGCCCAGATGGAGGTGGCCAGCTTCCTC 
                   
               
               
                   
                 CTGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAA 
                   
               
               
                   
                 GGAACATCAGAAAGCCTGGGCTTTGAACCTGAACGGTTTTGATGTAGA 
                   
               
               
                   
                 GGAAGCCAAGATCCTTCGGCTCAGTGGAAAAACCACAAAAATGCGCCA 
                   
               
               
                   
                 GAGGGTTATCACGAACAGACTGAAAGTACTCTACAGCCAAAAGGCCAC 
                   
               
               
                   
                 TCCTGGCTCCAGCCGGAAGACCTGCCGTTTACATTCCTTCCCTGCCAAG 
                   
               
               
                   
                 ACCGTATCCTGGATGCGCCTGAAATCGAATGACTATTAACTGAACCTGT 
                   
               
               
                   
                 GGGACTGGCAGTCCGGGGAATGTCCGGGCCGGGCCACGGCCACGAGGT 
                   
               
               
                   
                 GTTCCGTGTGGAGTGCAAGCTGGGACACACCGTGCCGCTTGTGCACAGG 
                   
               
               
                   
                 GCCACGCGGGGAAATAATCCCGGGGCGCGCAAAGCGGCACTGGCGAGA 
                   
               
               
                   
                 GCCGCACGGGCCGGTGCTGGGGGTGGTACAACAGGCCAAAACAACACA 
                   
               
               
                   
                 CAAGGCCAACAAGACATACGCGCGCTGACACCACGGTGCAAAGCGCTC 
                   
               
               
                   
                 AGACGAGTAGTAACCGGCACTGTGGTTGCTGCCTCCCCACCTCTCCCGC 
                   
               
               
                   
                 TCTCAGCGTAAGATAAAAGAAAGAAGAGCAAAAAGCAAAGAAAGAAG 
                   
               
               
                   
                 ACGAGACGAGACACACAGGAACGAACAGTAAAGCAAGCTAAAGCAAA 
                   
               
               
                   
                 CGCAAGACCAGACAACAGAAATAGAAAGAACCAACAGAGAGGAGACA 
                   
               
               
                   
                 GAACAGGACGCCAGCAACATAGCAACAAACGAACAGAAGAGAGCACT 
                   
               
               
                   
                 AAACAAAAGCAGCAGCAAGACGAGACAGGAGAGAAGGAGGAAGGAG 
                   
               
               
                   
                 GGCCGAGCGAGCAGGGAGCGCGAGCAGCGAGGCGAAGCAGCAGACAA 
                   
               
               
                   
                 GGGCAGGCGAAGGGCAACGAGAGGAGGCACCACACAAAAAGGAGAGG 
                   
               
               
                   
                 GGACAGGAGAAGCAGCGAGAGAAGCGGAGGAGCAACAAGAGGAAGA 
                   
               
               
                   
                 AAAGGAGAGGGAGAGGAGGGAGAGAGCGGAAGGAGGAAGAAACAGC 
                   
               
               
                   
                 ACGAGGCGACGAAGGGGGGAGACGCGGGGGCAGGAAAAGACACAGGA 
                   
               
               
                   
                 AGGCAGCGCGGAGGAGGAGAAGGGGAAGCAGGAAGGAGACGGAAGG 
                   
               
               
                   
                 AGAAGAGGGAGAGGACAGCGCAAGAGAGCGCGCGCGGCGACAGCGAG 
                   
               
               
                   
                 GGACGGAGCGAGAGAGAGGAAACGGAAAGCGAGAGGGAAGAGGAGA 
                   
               
               
                   
                 GGCAACGCAGCGAACCAACCGAAAACAGCAGAAAGAGAGGAGAAGGA 
                   
               
               
                   
                 CGCGCAAAGAGGCAAGCGCAAGACGACAGGAAACGAAGCGAGAGACG 
                   
               
               
                   
                 AGAAGCCGGTGACGAGCAGGAGAAAGGGAAGGCAGGAGACAGGACAG 
                   
               
               
                   
                 GCGGAAGAGAGACACGCGAGACGCAAAGAGTGAGCAGAACGAAGCGA 
                   
               
               
                   
                 AGAGCAACGCACGAGAGAAACGAC 
                   
               
               
                   
               
               
                 NM_001254 
                 GAGCGCGGCTGGAGTTTGCTGCTGCCGCTGTGCAGTTTGTTCAGGGGCT 
                 157 
               
               
                   
                 TGTGGTGGTGAGTCCGAGAGGCTGCGTGTGAGAGACGTGAGAAGGATC 
                   
               
               
                   
                 CTGCACTGAGGAGGTGGAAAGAAGAGGATTGCTCGAGGAGGCCTGGGG 
                   
               
               
                   
                 TCTGTGAGGCAGCGGAGCTGGGTGAAGGCTGCGGGTTCCGGCGAGGCC 
                   
               
               
                   
                 TGAGCTGTGCTGTCGTCATGCCTCAAACCCGATCCCAGGCACAGGCTAC 
                   
               
               
                   
                 AATCAGTTTTCCAAAAAGGAAGCTGTCTCGGGCATTGAACAAAGCTAA 
                   
               
               
                   
                 AAACTCCAGTGATGCCAAACTAGAACCAACAAATGTCCAAACCGTAAC 
                   
               
               
                   
                 CTGTTCTCCTCGTGTAAAAGCCCTGCCTCTCAGCCCCAGGAAACGTCTG 
                   
               
               
                   
                 GGCGATGACAACCTATGCAACACTCCCCATTTACCTCCTTGTTCTCCACC 
                   
               
               
                   
                 AAAGCAAGGCAAGAAAGAGAATGGTCCCCCTCACTCACATACACTTAA 
                   
               
               
                   
                 GGGACGAAGATTGGTATTTGACAATCAGCTGACAATTAAGTCTCCTAGC 
                   
               
               
                   
                 AAAAGAGAACTAGCCAAAGTTCACCAAAACAAAATACTTTCTTCAGTT 
                   
               
               
                   
                 AGAAAAAGTCAAGAGATCACAACAAATTCTGAGCAGAGATGTCCACTG 
                   
               
               
                   
                 AAGAAAGAATCTGCATGTGTGAGACTATTCAAGCAAGAAGGCACTTGC 
                   
               
               
                   
                 TACCAGCAAGCAAAGCTGGTCCTGAACACAGCTGTCCCAGATCGGCTG 
                   
               
               
                   
                 CCTGCCAGGGAAAGGGAGATGGATGTCATCAGGAATTTCTTGAGGGAA 
                   
               
               
                   
                 CACATCTGTGGGAAAAAAGCTGGAAGCCTTTACCTTTCTGGTGCTCCTG 
                   
               
               
                   
                 GAACTGGAAAAACTGCCTGCTTAAGCCGGATTCTGCAAGACCTCAAGA 
                   
               
               
                   
                 AGGAACTGAAAGGCTTTAAAACTATCATGCTGAATTGCATGTCCTTGAG 
                   
               
               
                   
                 GACTGCCCAGGCTGTATTCCCAGCTATTGCTCAGGAGATTTGTCAGGAA 
                   
               
               
                   
                 GAGGTATCCAGGCCAGCTGGGAAGGACATGATGAGGAAATTGGAAAAA 
                   
               
               
                   
                 CATATGACTGCAGAGAAGGGCCCCATGATTGTGTTGGTATTGGACGAG 
                   
               
               
                   
                 ATGGATCAACTGGACAGCAAAGGCCAGGATGTATTGTACACGCTATTTG 
                   
               
               
                   
                 AATGGCCATGGCTAAGCAATTCTCACTTGGTGCTGATTGGTATTGCTAA 
                   
               
               
                   
                 TACCCTGGATCTCACAGATAGAATTCTACCTAGGCTTCAAGCTAGAGAA 
                   
               
               
                   
                 AAATGTAAGCCACAGCTGTTGAACTTCCCACCTTATACCAGAAATCAGA 
                   
               
               
                   
                 TAGTCACTATTTTGCAAGATCGACTTAATCAGGTATCTAGAGATCAGGT 
                   
               
               
                   
                 TCTGGACAATGCTGCAGTTCAATTCTGTGCCCGCAAAGTCTCTGCTGTTT 
                   
               
               
                   
                 CAGGAGATGTTCGCAAAGCACTGGATGTTTGCAGGAGAGCTATTGAAA 
                   
               
               
                   
                 TTGTAGAGTCAGATGTCAAAAGCCAGACTATTCTCAAACCACTGTCTGA 
                   
               
               
                   
                 ATGTAAATCACCTTCTGAGCCTCTGATTCCCAAGAGGGTTGGTCTTATTC 
                   
               
               
                   
                 ACATATCCCAAGTCATCTCAGAAGTTGATGGTAACAGGATGACCTTGAG 
                   
               
               
                   
                 CCAAGAAGGAGCACAAGATTCCTTCCCTCTTCAGCAGAAGATCTTGGTT 
                   
               
               
                   
                 TGCTCTTTGATGCTCTTGATCAGGCAGTTGAAAATCAAAGAGGTCACTC 
                   
               
               
                   
                 TGGGGAAGTTATATGAAGCCTACAGTAAAGTCTGTCGCAAACAGCAGG 
                   
               
               
                   
                 TGGCGGCTGTGGACCAGTCAGAGTGTTTGTCACTTTCAGGGCTCTTGGA 
                   
               
               
                   
                 AGCCAGGGGCATTTTAGGATTAAAGAGAAACAAGGAAACCCGTTTGAC 
                   
               
               
                   
                 AAAGGTGTTTTTCAAGATTGAAGAGAAAGAAATAGAACATGCTCTGAA 
                   
               
               
                   
                 AGATAAAGCTTTAATTGGAAATATCTTAGCTACTGGATTGCCTTAAATT 
                   
               
               
                   
                 CTTCTCTTACACCCCACCCGAAAGTATTCAGCTGGCATTTAGAGAGCTA 
                   
               
               
                   
                 CAGTCTTCATTTTAGTGCTTTACACATTCGGGCCTGAAAACAAATATGA 
                   
               
               
                   
                 CCTTTTTTACTTGAAGCCAATGAATTTTAATCTATAGATTCTTTAATATT 
                   
               
               
                   
                 AGCACAGAATAATATCTTTGGGTCTTACTATTTTTACCCATAAAAGTGA 
                   
               
               
                   
                 CCAGGTAGACCCTTTTTAATTACATTCACTACTTCTACCACTTGTGTATC 
                   
               
               
                   
                 TCTAGCCAATGTGCTTGCAAGTGTACAGATCTGTGTAGAGGAATGTGTG 
                   
               
               
                   
                 TATATTTACCTCTTCGTTTGCTCAAACATGAGTGGGTATTTTTTTGTTTGT 
                   
               
               
                   
                 TTTTTTTGTTGTTGTTGTTTTTGAGGCGCGTCTCACCCTGTTGCCCAGGCT 
                   
               
               
                   
                 GGAGTGCAATGGCGCGTTCTCTGCTCACTACAGCACCCGCTTCCCAGGT 
                   
               
               
                   
                 TGAAGTGATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTG 
                   
               
               
                   
                 CCCACCACCGCGCCCAGCTAATTTTTTAATTTTTAGTAGAGACAGGGTT 
                   
               
               
                   
                 TTACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCCTCAAGTGATCT 
                   
               
               
                   
                 GCCCACCTTGGCCTCCCTAAGTGCTGGGATTATAGGCGTGAGCCACCAT 
                   
               
               
                   
                 GCTCAGCCATTAAGGTATTTTGTTAAGAACTTTAAGTTTAGGGTAAGAA 
                   
               
               
                   
                 GAATGAAAATGATCCAGAAAAATGCAAGCAAGTCCACATGGAGATTTG 
                   
               
               
                   
                 GAGGACACTGGTTAAAGAATTTATTTCTTTGTATAGTATACTATGTTCAT 
                   
               
               
                   
                 GGTGCAGATACTACAACATTGTGGCATTTTAGACTCGTTGAGTTTCTTG 
                   
               
               
                   
                 GGCACTCCCAAGGGCGTTGGGGTCATAAGGAGACTATAACTCTACAGA 
                   
               
               
                   
                 TTGTGAATATATTTATTTCAAGTTGCATTCTTTGTCTTTTTAAGCAATC 
                   
               
               
                   
                 AGATTTCAAGAGAGCTCAAGCTTTCAGAAGTCAATGTGAAAATTCCTTC 
                   
               
               
                   
                 CTAGGCTGTCCCACAGTCTTTGCTGCCCTTAGATGAAGCCACTTGTTTCA 
                   
               
               
                   
                 AGATGACTACTTTGGGGTTGGGTTTTCATCTAAACACATTTTTCCAGTCT 
                   
               
               
                   
                 TATTAGATAAATTAGTCCATATGGTTGGTTAATCAAGAGCCTTCTGGGT 
                   
               
               
                   
                 TTGGTTTGGTGGCATTAAATGG 
                   
               
               
                   
               
               
                 NM_031423 
                 GCGGAATGGGGCGGGACTTCCAGTAGGAGGCGGCAAGTTTGAAAAGTG 
                 158 
               
               
                   
                 ATGACGGTTGACGTTTGCTGATTTTTGACTTTGCTTGTAGCTGCTCCCCG 
                   
               
               
                   
                 AACTCGCCGTCTTCCTGTCGGCGGCCGGCACTGTAGATTAACAGGAAAC 
                   
               
               
                   
                 TTCCAAGATGGAAACTTTGTCTTTCCCCAGATATAATGTAGCTGAGATT 
                   
               
               
                   
                 GTGATTCATATTCGCAATAAGATCTTAACAGGAGCTGATGGTAAAAACC 
                   
               
               
                   
                 TCACCAAGAATGATCTTTATCCAAATCCAAAGCCTGAAGTCTTGCACAT 
                   
               
               
                   
                 GATCTACATGAGAGCCTTACAAATAGTATATGGAATTCGACTGGAACAT 
                   
               
               
                   
                 TTTTACATGATGCCAGTGAACTCTGAAGTCATGTATCCACATTTAATGG 
                   
               
               
                   
                 AAGGCTTCTTACCATTCAGCAATTTAGTTACTCATCTGGACTCATTTTTG 
                   
               
               
                   
                 CCTATCTGCCGGGTGAATGACTTTGAGACTGCTGATATTCTATGTCCAA 
                   
               
               
                   
                 AAGCAAAACGGACAAGTCGGTTTTTAAGTGGCATTATCAACTTTATTCA 
                   
               
               
                   
                 CTTCAGAGAAGCATGCCGTGAAACGTATATGGAATTTCTTTGGCAATAT 
                   
               
               
                   
                 AAATCCTCTGCGGACAAAATGCAACAGTTAAACGCCGCACACCAGGAG 
                   
               
               
                   
                 GCATTAATGAAACTGGAGAGACTTGATTCTGTTCCAGTTGAAGAGCAAG 
                   
               
               
                   
                 AAGAGTTCAAGCAGCTTTCAGATGGAATTCAGGAGCTACAACAATCAC 
                   
               
               
                   
                 TAAATCAGGATTTTCATCAAAAAACGATAGTGCTGCAAGAGGGAAATT 
                   
               
               
                   
                 CCCAAAAGAAGTCAAATATTTCAGAGAAAACCAAGCGTTTGAATGAAC 
                   
               
               
                   
                 TAAAATTGTCGGTGGTTTCTTTGAAAGAAATACAAGAGAGTTTGAAAAC 
                   
               
               
                   
                 AAAAATTGTGGATTCTCCAGAGAAGTTAAAGAATTATAAAGAAAAAAT 
                   
               
               
                   
                 GAAAGATACGGTCCAGAAGCTTAAAAATGCCAGACAAGAAGTGGTGGA 
                   
               
               
                   
                 GAAATATGAAATCTATGGAGACTCAGTTGACTGCCTGCCTTCATGTCAG 
                   
               
               
                   
                 TTGGAAGTGCAGTTATATCAAAAGAAAATACAGGACCTTTCAGATAAT 
                   
               
               
                   
                 AGGGAAAAATTAGCCAGTATCTTAAAGGAGAGCCTGAACTTGGAGGAC 
                   
               
               
                   
                 CAAATTGAGAGTGATGAGTCAGAACTGAAGAAATTGAAGACTGAAGAA 
                   
               
               
                   
                 AATTCGTTCAAAAGACTGATGATTGTGAAGAAGGAAAAACTTGCCACA 
                   
               
               
                   
                 GCACAATTCAAAATAAATAAGAAGCATGAAGATGTTAAGCAATACAAA 
                   
               
               
                   
                 CGCACAGTAATTGAGGATTGCAATAAAGTTCAAGAAAAAAGAGGTGCT 
                   
               
               
                   
                 GTCTATGAACGAGTAACCACAATTAATCAAGAAATCCAAAAAATTAAA 
                   
               
               
                   
                 CTTGGAATTCAACAACTAAAAGATGCTGCTGAAAGGGAGAAACTGAAG 
                   
               
               
                   
                 TCCCAGGAAATATTTCTAAACTTGAAAACTGCTTTGGAGAAATACCACG 
                   
               
               
                   
                 ACGGTATTGAAAAGGCAGCAGAGGACTCCTATGCTAAGATAGATGAGA 
                   
               
               
                   
                 AGACAGCTGAACTGAAGAGGAAGATGTTCAAAATGTCAACCTGATTAA 
                   
               
               
                   
                 CAAAATTACATGTCTTTTTGTAAATGGCTTGCCATCTTTTAATTTTCTAT 
                   
               
               
                   
                 TTAGAAAGAAAAGTTGAAGCGAATGGAAGTATCAGAAGTACCAAATAA 
                   
               
               
                   
                 TGTTGGCTTCATCAGTTTTTATACACTCTCATAAGTAGTTAATAAGATGA 
                   
               
               
                   
                 ATTTAATGTAGGCTTTTATTAATTTATAATTAAAATAACTTGTGCAGCTA 
                   
               
               
                   
                 TTCATGTCTCTACTCTGCCCCTTGTTGTAAATAGTTTGAGTAAAACAAAA 
                   
               
               
                   
                 CTAGTTACCTTTGAAATATATATATTTTTTTCTGTTACTATC 
                   
               
               
                   
               
               
                 BC041846 
                 GGCTAGCGCGGGAGGTGGAGAAAGAGGCTTGGGCGGCCCCGCTGTAGC 
                 159 
               
               
                   
                 CGCGTGTGGGAGGACGCACGGGCCTGCTTCAAAGCTTTGGGATAACAG 
                   
               
               
                   
                 CGCCTCCGGGGGATAATGAATGCGGAGCCTCCGTTTTCAGTCGACTTCA 
                   
               
               
                   
                 GATGTGTCTCCACTTTTTTCCGCTGTAGCCGCAAGGCAAGGAAACATTT 
                   
               
               
                   
                 CTCTTCCCGTACTGAGGAGGCTGAGGAGTGCACTGGGTGTTCTTTTCTC 
                   
               
               
                   
                 CTCTAACCCAGAACTGCGAGACAGAGGCTGAGTCCCTGTAAAGAACAG 
                   
               
               
                   
                 CTCCAGAAAAGCCAGGAGAGCGCAGGAGGGCATCCGGGAGGCCAGGA 
                   
               
               
                   
                 GGGGTTCGCTGGGGCCTCAACCGCACCCACATCGGTCCCACCTGCGAGG 
                   
               
               
                   
                 GGGCGGGACCTCGTGGCGCTGGACCAATCAGCACCCACCTGCGCTCAC 
                   
               
               
                   
                 CTGGCCTCCTCCCGCTGGCTCCCGGGGGCTGCGGTGCTCAAAGGGGCAA 
                   
               
               
                   
                 GAGCTGAGCGGAACACCGGCCCGCCGTCGCGGCAGCTGCTTCACCCCTC 
                   
               
               
                   
                 TCTCTGCAGCCATGGGGCTCCCTCGTGGACCTCTCGCGTCTCTCCTCCTT 
                   
               
               
                   
                 CTCCAGGTTTGCTGGCTGCAGTGCGCGGCCTCCGAGCCGTGCCGGGCGG 
                   
               
               
                   
                 TCTTCAGGGAGGCTGAAGTGACCTTGGAGGCGGGAGGCGCGGAGCAGG 
                   
               
               
                   
                 AGCCCGGCCAGGCGCTGGGGAAAGTATTCATGGGCTGCCCTGGGCAAG 
                   
               
               
                   
                 AGCCAGCTCTGTTTAGCACTGATAATGATGACTTCACTGTGCGGAATGG 
                   
               
               
                   
                 CGAGACAGTCCAGGAAAGAAGGTCACTGAAGGAAAGGAATCCATTGAA 
                   
               
               
                   
                 GATCTTCCCATCCAAACGTATCTTACGAAGACACAAGAGAGATTGGGTG 
                   
               
               
                   
                 GTTGCTCCAATATCTGTCCCTGAAAATGGCAAGGGTCCCTTCCCCCAGA 
                   
               
               
                   
                 GACTGAATCAGCTCAAGTCTAATAAAGATAGAGACACCAAGATTTTCTA 
                   
               
               
                   
                 CAGCATCACGGGGCCGGGGGCAGACAGCCCCCCTGAGGGTGTCTTCGC 
                   
               
               
                   
                 TGTAGAGAAGGAGACAGGCTGGTTGTTGTTGAATAAGCCACTGGACCG 
                   
               
               
                   
                 GGAGGAGATTGCCAAGTATGAGCTCTTTGGCCACGCTGTGTCAGAGAAT 
                   
               
               
                   
                 GGTGCCTCAGTGGAGGACCCCATGAACATCTCCATCATAGTGACCGACC 
                   
               
               
                   
                 AGAATGACCACAAGCCCAAGTTTACCCAGGACACCTTCCGAGGGAGTG 
                   
               
               
                   
                 TCTTAGAGGGAGTCCTACCAGGTACTTCTGTGATGCAGATGACAGCCAC 
                   
               
               
                   
                 AGATGAGGATGATGCCATCTACACCTACAATGGGGTGGTTGCTTACTCC 
                   
               
               
                   
                 ATCCATAGCCAAGAACCAAAGGACCCACACGACCTCATGTTCACAATTC 
                   
               
               
                   
                 ACCGGAGCACAGGCACCATCAGCGTCATCTCCAGTGGCCTGGACCGGG 
                   
               
               
                   
                 AAAAAGTCCCTGAGTACACACTGACCATCCAGGCCACAGACATGGATG 
                   
               
               
                   
                 GGGACGGCTCCACCACCACGGCAGTGGCAGTAGTGGAGATCCTTGATG 
                   
               
               
                   
                 CCAATGACAATGCTCCCATGTTTGACCCCCAGAAGTACGAGGCCCATGT 
                   
               
               
                   
                 GCCTGAGAATGCAGTGGGCCATGAGGTGCAGAGGCTGACGGTCACTGA 
                   
               
               
                   
                 TCTGGACGCCCCCAACTCACCAGCGTGGCGTGCCACCTACCTTATCATG 
                   
               
               
                   
                 GGCGGTGACGACGGGGACCATTTTACCATCACCACCCACCCTGAGAGC 
                   
               
               
                   
                 AACCAGGGCATCCTGACAACCAGGAAGGGTTTGGATTTTGAGGCCAAA 
                   
               
               
                   
                 AACCAGCACACCCTGTACGTTGAAGTGACCAACGAGGCCCCTTTTGTGC 
                   
               
               
                   
                 TGAAGCTCCCAACCTCCACAGCCACCATAGTGGTCCACGTGGAGGATGT 
                   
               
               
                   
                 GAATGAGGCACCTGTGTTTGTCCCACCCTCCAAAGTCGTTGAGGTCCAG 
                   
               
               
                   
                 GAGGGCATCCCCACTGGGGAGCCTGTGTGTGTCTACACTGCAGAAGAC 
                   
               
               
                   
                 CCTGACAAGGAGAATCAAAAGATCAGCTACCGCATCCTGAGAGACCCA 
                   
               
               
                   
                 GCAGGGTGGCTAGCCATGGACCCAGACAGTGGGCAGGTCACAGCTGTG 
                   
               
               
                   
                 GGCACCCTCGACCGTGAGGATGAGCAGTTTGTGAGGAACAACATCTAT 
                   
               
               
                   
                 GAAGTCATGGTCTTGGCCATGGACAATGGAAGCCCTCCCACCACTGGCA 
                   
               
               
                   
                 CGGGAACCCTTCTGCTAACACTGATTGATGTCAACGACCATGGCCCAGT 
                   
               
               
                   
                 CCCTGAGCCCCGTCAGATCACCATCTGCAACCAAAGCCCTGTGCGCCAG 
                   
               
               
                   
                 GTGCTGAACATCACGGACAAGGACCTGTCTCCCCACACCTCCCCTTTCC 
                   
               
               
                   
                 AGGCCCAGCTCACAGATGACTCAGACATCTACTGGACGGCAGAGGTCA 
                   
               
               
                   
                 ACGAGGAAGGTGACACAGTGGTCTTGTCCCTGAAGAAGTTCCTGAAGC 
                   
               
               
                   
                 AGGATACATATGACGTGCACCTTTCTCTGTCTGACCATGGCAACAAAGA 
                   
               
               
                   
                 GCAGCTGACGGTGATCAGGGCCACTGTGTGCGACTGCCATGGCCATGTC 
                   
               
               
                   
                 GAAACCTGCCCTGGACCCTGGAAAGGAGGTTTCATCCTCCCTGTGCTGG 
                   
               
               
                   
                 GGGCTGTCCTGGCTCTGCTGTTCCTCCTGCTGGTGCTGCTTTTGTTGGTG 
                   
               
               
                   
                 AGAAAGAAGCGGAAGATCAAGGAGCCCCTCCTACTCCCAGAAGATGAC 
                   
               
               
                   
                 ACCCGTGACAACGTCTTCTACTATGGCGAAGAGGGGGGTGGCGAAGAG 
                   
               
               
                   
                 GACCAGGACTATGACATCACCCAGCTCCACCGAGGTCTGGAGGCCAGG 
                   
               
               
                   
                 CCGGAGGTGGTTCTCCGCAATGACGTGGCACCAACCATCATCCCGACAC 
                   
               
               
                   
                 CCATGTACCGTCCTAGGCCAGCCAACCCAGATGAAATCGGCAACTTTAT 
                   
               
               
                   
                 AATTGAGAACCTGAAGGCGGCTAACACAGACCCCACAGCCCCGCCCTA 
                   
               
               
                   
                 CGACACCCTCTTGGTGTTCGACTATGAGGGCAGCGGCTCCGACGCCGCG 
                   
               
               
                   
                 TCCCTGAGCTCCCTCACCTCCTCCGCCTCCGACCAAGACCAAGATTACG 
                   
               
               
                   
                 ATTATCTGAACGAGTGGGGCAGCCGCTTCAAGAAGCTGGCAGACATGT 
                   
               
               
                   
                 ACGGTGGCGGGGAGGACGACTAGGCGGCCTGCCTGCAGGGCTGGGGAC 
                   
               
               
                   
                 CAAACGTCAGGCCACAGAGCATCTCCAAGGGGTCTCAGTTCCCCCTTCA 
                   
               
               
                   
                 GCTGAGGACTTCGGAGCTTGTCAGGAAGTGGCCGTAGCAACTTGGCGG 
                   
               
               
                   
                 AGACAGGCTATGAGTCTGACGTTAGAGTGGTTGCTTCCTTAGCCTTTCA 
                   
               
               
                   
                 GGATGGAGGAATGTGGGCAGTTTGACTTCAGCACTGAAAACCTCTCCAC 
                   
               
               
                   
                 CTGGGCCAGGGTTGCCTCAGAGGCCAAGTTTCCAGAAGCCTCTTACCTG 
                   
               
               
                   
                 CCGTAAAATGCTCAACCCTGTGTCCTGGGCCTGGGCCTGCTGTGACTGA 
                   
               
               
                   
                 CCTACAGTGGACTTTCTCTCTGGAATGGAACCTTCTTAGGCCTCCTGGTG 
                   
               
               
                   
                 CAACTTAATTTTTTTTTTTAATGCTATCTTCAAAACGTTAGAGAAAGTTC 
                   
               
               
                   
                 TTCAAAAGTGCAGCCCAGAGCTGCTGGGCCCACTGGCCGTCCTGCATTT 
                   
               
               
                   
                 CTGGTTTCCAGACCCCAATGCCTCCCATTCGGATGGATCTCTGCGTTTTT 
                   
               
               
                   
                 ATACTGAGTGTGCCTAGGTTGCCCCTTATTTTTTATTTTCCCTGTTGCGTT 
                   
               
               
                   
                 GCTATAGATGAAGGGTGAGGACAATCGTGTATATGTACTAGAACTTTTT 
                   
               
               
                   
                 TATTAAAGAAACTTTTCCCAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_016343 
                 GAGACCAGAAGCGGGCGAATTGGGCACCGGTGGCGGCTGCGGGCAGTT 
                 160 
               
               
                   
                 TGAATTAGACTCTGGGCTCCAGCCCGCCGAAGCCGCGCCAGAACTGTAC 
                   
               
               
                   
                 TCTCCGAGAGGTCGTTTTCCCGTCCCCGAGAGCAAGTTTATTTACAAAT 
                   
               
               
                   
                 GTTGGAGTAATAAAGAAGGCAGAACAAAATGAGCTGGGCTTTGGAAGA 
                   
               
               
                   
                 ATGGAAAGAAGGGCTGCCTACAAGAGCTCTTCAGAAAATTCAAGAGCT 
                   
               
               
                   
                 TGAAGGACAGCTTGACAAACTGAAGAAGGAAAAGCAGCAAAGGCAGT 
                   
               
               
                   
                 TTCAGCTTGACAGTCTCGAGGCTGCGCTGCAGAAGCAAAAACAGAAGG 
                   
               
               
                   
                 TTGAAAATGAAAAAACCGAGGGTACAAACCTGAAAAGGGAGAATCAA 
                   
               
               
                   
                 AGATTGATGGAAATATGTGAAAGTCTGGAGAAAACTAAGCAGAAGATT 
                   
               
               
                   
                 TCTCATGAACTTCAAGTCAAGGAGTCACAAGTGAATTTCCAGGAAGGA 
                   
               
               
                   
                 CAACTGAATTCAGGCAAAAAACAAATAGAAAAACTGGAACAGGAACTT 
                   
               
               
                   
                 AAAAGGTGTAAATCTGAGCTTGAAAGAAGCCAACAAGCTGCGCAGTCT 
                   
               
               
                   
                 GCAGATGTCTCTCTGAATCCATGCAATACACCACAAAAAATTTTTACAA 
                   
               
               
                   
                 CTCCACTAACACCAAGTCAATATTATAGTGGTTCCAAGTATGAAGATCT 
                   
               
               
                   
                 AAAAGAAAAATATAATAAAGAGGTTGAAGAACGAAAAAGATTAGAGG 
                   
               
               
                   
                 CAGAGGTTAAAGCCTTGCAGGCTAAAAAAGCAAGCCAGACTCTTCCAC 
                   
               
               
                   
                 AAGCCACCATGAATCACCGCGACATTGCCCGGCATCAGGCTTCATCATC 
                   
               
               
                   
                 TGTGTTCTCATGGCAGCAAGAGAAGACCCCAAGTCATCTTTCATCTAAT 
                   
               
               
                   
                 TCTCAAAGAACTCCAATTAGGAGAGATTTCTCTGCATCTTACTTTTCTGG 
                   
               
               
                   
                 GGAACAAGAGGTGACTCCAAGTCGATCAACTTTGCAAATAGGGAAAAG 
                   
               
               
                   
                 AGATGCTAATAGCAGTTTCTTTGACAATTCTAGCAGTCCTCATCTTTTGG 
                   
               
               
                   
                 ATCAATTAAAAGCGCAGAATCAAGAGCTAAGAAACAAGATTAATGAGT 
                   
               
               
                   
                 TGGAACTACGCCTGCAAGGACATGAAAAAGAAATGAAAGGCCAAGTGA 
                   
               
               
                   
                 ATAAGTTTCAAGAACTCCAACTCCAACTGGAGAAAGCAAAAGTGGAAT 
                   
               
               
                   
                 TAATTGAAAAAGAGAAAGTTTTGAACAAATGTAGGGATGAACTAGTGA 
                   
               
               
                   
                 GAACAACAGCACAATACGACCAGGCGTCAACCAAGTATACTGCATTGG 
                   
               
               
                   
                 AACAAAAACTGAAAAAATTGACGGAAGATTTGAGTTGTCAGCGACAAA 
                   
               
               
                   
                 ATGCAGAAAGTGCCAGATGTTCTCTGGAACAGAAAATTAAGGAAAAAG 
                   
               
               
                   
                 AAAAGGAGTTTCAAGAGGAGCTCTCCCGTCAACAGCGTTCTTTCCAAAC 
                   
               
               
                   
                 ACTGGACCAGGAGTGCATCCAGATGAAGGCCAGACTCACCCAGGAGTT 
                   
               
               
                   
                 ACAGCAAGCCAAGAATATGCACAACGTCCTGCAGGCTGAACTGGATAA 
                   
               
               
                   
                 ACTCACATCAGTAAAGCAACAGCTAGAAAACAATTTGGAAGAGTTTAA 
                   
               
               
                   
                 GCAAAAGTTGTGCAGAGCTGAACAGGCGTTCCAGGCGAGTCAGATCAA 
                   
               
               
                   
                 GGAGAATGAGCTGAGGAGAAGCATGGAGGAAATGAAGAAGGAAAACA 
                   
               
               
                   
                 ACCTCCTTAAGAGTCACTCTGAGCAAAAGGCCAGAGAAGTCTGCCACCT 
                   
               
               
                   
                 GGAGGCAGAACTCAAGAACATCAAACAGTGTTTAAATCAGAGCCAGAA 
                   
               
               
                   
                 TTTTGCAGAAGAAATGAAAGCGAAGAATACCTCTCAGGAAACCATGTT 
                   
               
               
                   
                 AAGAGATCTTCAAGAAAAAATAAATCAGCAAGAAAACTCCTTGACTTT 
                   
               
               
                   
                 AGAAAAACTGAAGCTTGCTGTGGCTGATCTGGAAAAGCAGCGAGATTG 
                   
               
               
                   
                 TTCTCAAGACCTTTTGAAGAAAAGAGAACATCACATTGAACAACTTAAT 
                   
               
               
                   
                 GATAAGTTAAGCAAGACAGAGAAAGAGTCCAAAGCCTTGCTGAGTGCT 
                   
               
               
                   
                 TTAGAGTTAAAAAAGAAAGAATATGAAGAATTGAAAGAAGAGAAAAC 
                   
               
               
                   
                 TCTGTTTTCTTGTTGGAAAAGTGAAAACGAAAAACTTTTAACTCAGATG 
                   
               
               
                   
                 GAATCAGAAAAGGAAAACTTGCAGAGTAAAATTAATCACTTGGAAACT 
                   
               
               
                   
                 TGTCTGAAGACACAGCAAATAAAAAGTCATGAATACAACGAGAGAGTA 
                   
               
               
                   
                 AGAACGCTGGAGATGGACAGAGAAAACCTAAGTGTCGAGATCAGAAAC 
                   
               
               
                   
                 CTTCACAACGTGTTAGACAGTAAGTCAGTGGAGGTAGAGACCCAGAAA 
                   
               
               
                   
                 CTAGCTTATATGGAGCTACAGCAGAAAGCTGAGTTCTCAGATCAGAAA 
                   
               
               
                   
                 CATCAGAAGGAAATAGAAAATATGTGTTTGAAGACTTCTCAGCTTACTG 
                   
               
               
                   
                 GGCAAGTTGAAGATCTAGAACACAAGCTTCAGTTACTGTCAAATGAAA 
                   
               
               
                   
                 TAATGGACAAAGACCGGTGTTACCAAGACTTGCATGCCGAATATGAGA 
                   
               
               
                   
                 GCCTCAGGGATCTGCTAAAATCCAAAGATGCTTCTCTGGTGACAAATGA 
                   
               
               
                   
                 AGATCATCAGAGAAGTCTTTTGGCTTTTGATCAGCAGCCTGCCATGCAT 
                   
               
               
                   
                 CATTCCTTTGCAAATATAATTGGAGAACAAGGAAGCATGCCTTCAGAGA 
                   
               
               
                   
                 GGAGTGAATGTCGTTTAGAAGCAGACCAAAGTCCGAAAAATTCTGCCA 
                   
               
               
                   
                 TCCTACAAAATAGAGTTGATTCACTTGAATTTTCATTAGAGTCTCAAAA 
                   
               
               
                   
                 ACAGATGAACTCAGACCTGCAAAAGCAGTGTGAAGAGTTGGTGCAAAT 
                   
               
               
                   
                 CAAAGGAGAAATAGAAGAAAATCTCATGAAAGCAGAACAGATGCATC 
                   
               
               
                   
                 AAAGTTTTGTGGCTGAAACAAGTCAGCGCATTAGTAAGTTACAGGAAG 
                   
               
               
                   
                 ACACTTCTGCTCACCAGAATGTTGTTGCTGAAACCTTAAGTGCCCTTGA 
                   
               
               
                   
                 GAACAAGGAAAAAGAGCTGCAACTTTTAAATGATAAGGTAGAAACTGA 
                   
               
               
                   
                 GCAGGCAGAGATTCAAGAATTAAAAAAGAGCAACCATCTACTTGAAGA 
                   
               
               
                   
                 CTCTCTAAAGGAGCTACAACTTTTATCCGAAACCCTAAGCTTGGAGAAG 
                   
               
               
                   
                 AAAGAAATGAGTTCCATCATTTCTCTAAATAAAAGGGAAATTGAAGAG 
                   
               
               
                   
                 CTGACCCAAGAGAATGGGACTCTTAAGGAAATTAATGCATCCTTAAATC 
                   
               
               
                   
                 AAGAGAAGATGAACTTAATCCAGAAAAGTGAGAGTTTTGCAAACTATA 
                   
               
               
                   
                 TAGATGAAAGGGAGAAAAGCATTTCAGAGTTATCTGATCAGTACAAGC 
                   
               
               
                   
                 AAGAAAAACTTATTTTACTACAAAGATGTGAAGAAACCGGAAATGCAT 
                   
               
               
                   
                 ATGAGGATCTTAGTCAAAAATACAAAGCAGCACAGGAAAAGAATTCTA 
                   
               
               
                   
                 AATTAGAATGCTTGCTAAATGAATGCACTAGTCTTTGTGAAAATAGGAA 
                   
               
               
                   
                 AAATGAGTTGGAACAGCTAAAGGAAGCATTTGCAAAGGAACACCAAGA 
                   
               
               
                   
                 ATTCTTAACAAAATTAGCATTTGCTGAAGAAAGAAATCAGAATCTGATG 
                   
               
               
                   
                 CTAGAGTTGGAGACAGTGCAGCAAGCTCTGAGATCTGAGATGACAGAT 
                   
               
               
                   
                 AACCAAAACAATTCTAAGAGCGAGGCTGGTGGTTTAAAGCAAGAAATC 
                   
               
               
                   
                 ATGACTTTAAAGGAAGAACAAAACAAAATGCAAAAGGAAGTTAATGAC 
                   
               
               
                   
                 TTATTACAAGAGAATGAACAGCTGATGAAGGTAATGAAGACTAAACAT 
                   
               
               
                   
                 GAATGTCAAAATCTAGAATCAGAACCAATTAGGAACTCTGTGAAAGAA 
                   
               
               
                   
                 AGAGAGAGTGAGAGAAATCAATGTAATTTTAAACCTCAGATGGATCTT 
                   
               
               
                   
                 GAAGTTAAAGAAATTTCTCTAGATAGTTATAATGCGCAGTTGGTGCAAT 
                   
               
               
                   
                 TAGAAGCTATGCTAAGAAATAAGGAATTAAAACTTCAGGAAAGTGAGA 
                   
               
               
                   
                 AGGAGAAGGAGTGCCTGCAGCATGAATTACAGACAATTAGAGGAGATC 
                   
               
               
                   
                 TTGAAACCAGCAATTTGCAAGACATGCAGTCACAAGAAATTAGTGGCC 
                   
               
               
                   
                 TTAAAGACTGTGAAATAGATGCGGAAGAAAAGTATATTTCAGGGCCTC 
                   
               
               
                   
                 ATGAGTTGTCAACAAGTCAAAACGACAATGCACACCTTCAGTGCTCTCT 
                   
               
               
                   
                 GCAAACAACAATGAACAAGCTGAATGAGCTAGAGAAAATATGTGAAAT 
                   
               
               
                   
                 ACTGCAGGCTGAAAAGTATGAACTCGTAACTGAGCTGAATGATTCAAG 
                   
               
               
                   
                 GTCAGAATGTATCACAGCAACTAGGAAAATGGCAGAAGAGGTAGGGAA 
                   
               
               
                   
                 ACTACTAAATGAAGTTAAAATATTAAATGATGACAGTGGTCTTCTCCAT 
                   
               
               
                   
                 GGTGAGTTAGTGGAAGACATACCAGGAGGTGAATTTGGTGAACAACCA 
                   
               
               
                   
                 AATGAACAGCACCCTGTGTCTTTGGCTCCATTGGACGAGAGTAATTCCT 
                   
               
               
                   
                 ACGAGCACTTGACATTGTCAGACAAAGAAGTTCAAATGCACTTTGCCGA 
                   
               
               
                   
                 ATTGCAAGAGAAATTCTTATCTTTACAAAGTGAACACAAAATTTTACAT 
                   
               
               
                   
                 GATCAGCACTGTCAGATGAGCTCTAAAATGTCAGAGCTGCAGACCTATG 
                   
               
               
                   
                 TTGACTCATTAAAGGCCGAAAATTTGGTCTTGTCAACGAATCTGAGAAA 
                   
               
               
                   
                 CTTTCAAGGTGACTTGGTGAAGGAGATGCAGCTGGGCTTGGAGGAGGG 
                   
               
               
                   
                 GCTCGTTCCATCCCTGTCATCCTCTTGTGTGCCTGACAGCTCTAGTCTTA 
                   
               
               
                   
                 GCAGTTTGGGAGACTCCTCCTTTTACAGAGCTCTTTTAGAACAGACAGG 
                   
               
               
                   
                 AGATATGTCTCTTTTGAGTAATTTAGAAGGGGCTGTTTCAGCAAACCAG 
                   
               
               
                   
                 TGCAGTGTAGATGAAGTATTTTGCAGCAGTCTGCAGGAGGAGAATCTG 
                   
               
               
                   
                 ACCAGGAAAGAAACCCCTTCGGCCCCAGCGAAGGGTGTTGAAGAGCTT 
                   
               
               
                   
                 GAGTCCCTCTGTGAGGTGTACCGGCAGTCCCTCGAGAAGCTAGAAGAG 
                   
               
               
                   
                 AAAATGGAAAGTCAAGGGATTATGAAAAATAAGGAAATTCAAGAGCTC 
                   
               
               
                   
                 GAGCAGTTATTAAGTTCTGAAAGGCAAGAGCTTGACTGCCTTAGGAAG 
                   
               
               
                   
                 CAGTATTTGTCAGAAAATGAACAGTGGCAACAGAAGCTGACAAGCGTG 
                   
               
               
                   
                 ACTCTGGAGATGGAGTCCAAGTTGGCGGCAGAAAAGAAACAGACGGAA 
                   
               
               
                   
                 CAACTGTCACTTGAGCTGGAAGTAGCACGACTCCAGCTACAAGGTCTGG 
                   
               
               
                   
                 ACTTAAGTTCTCGGTCTTTGCTTGGCATCGACACAGAAGATGCTATTCA 
                   
               
               
                   
                 AGGCCGAAATGAGAGCTGTGACATATCAAAAGAACATACTTCAGAAAC 
                   
               
               
                   
                 TACAGAAAGAACACCAAAGCATGATGTTCATCAGATTTGTGATAAAGA 
                   
               
               
                   
                 TGCTCAGCAGGACCTCAATCTAGACATTGAGAAAATAACTGAGACTGG 
                   
               
               
                   
                 TGCAGTGAAACCCACAGGAGAGTGCTCTGGGGAACAGTCCCCAGATAC 
                   
               
               
                   
                 CAATTATGAGCCTCCAGGGGAAGATAAAACCCAGGGCTCTTCAGAATG 
                   
               
               
                   
                 CATTTCTGAATTGTCATTTTCTGGTCCTAATGCTTTGGTACCTATGGATT 
                   
               
               
                   
                 TCCTGGGGAATCAGGAAGATATCCATAATCTTCAACTGCGGGTAAAAG 
                   
               
               
                   
                 AGACATCAAATGAGAATTTGAGATTACTTCATGTGATAGAGGACCGTG 
                   
               
               
                   
                 ACAGAAAAGTTGAAAGTTTGCTAAATGAAATGAAAGAATTAGACTCAA 
                   
               
               
                   
                 AACTCCATTTACAGGAGGTACAACTAATGACCAAAATTGAAGCATGCA 
                   
               
               
                   
                 TAGAATTGGAAAAAATAGTTGGGGAACTTAAGAAAGAAAACTCAGATT 
                   
               
               
                   
                 TAAGTGAAAAATTGGAATATTTTTCTTGTGATCACCAGGAGTTACTCCA 
                   
               
               
                   
                 GAGAGTAGAAACTTCTGAAGGCCTCAATTCTGATTTAGAAATGCATGCA 
                   
               
               
                   
                 GATAAATCATCACGTGAAGATATTGGAGATAATGTGGCCAAGGTGAAT 
                   
               
               
                   
                 GACAGCTGGAAGGAGAGATTTCTTGATGTGGAAAATGAGCTGAGTAGG 
                   
               
               
                   
                 ATCAGATCGGAGAAAGCTAGCATTGAGCATGAAGCCCTCTACCTGGAG 
                   
               
               
                   
                 GCTGACTTAGAGGTAGTTCAAACAGAGAAGCTATGTTTAGAAAAAGAC 
                   
               
               
                   
                 AATGAAAATAAGCAGAAGGTTATTGTCTGCCTTGAAGAAGAACTCTCA 
                   
               
               
                   
                 GTGGTCACAAGTGAGAGAAACCAGCTTCGTGGAGAATTAGATACTATG 
                   
               
               
                   
                 TCAAAAAAAACCACGGCACTGGATCAGTTGTCTGAAAAAATGAAGGAG 
                   
               
               
                   
                 AAAACACAAGAGCTTGAGTCTCATCAAAGTGAGTGTCTCCATTGCATTC 
                   
               
               
                   
                 AGGTGGCAGAGGCAGAGGTGAAGGAAAAGACGGAACTCCTTCAGACTT 
                   
               
               
                   
                 TGTCCTCTGATGTGAGTGAGCTGTTAAAAGACAAAACTCATCTCCAGGA 
                   
               
               
                   
                 AAAGCTGCAGAGTTTGGAAAAGGACTCACAGGCACTGTCTTTGACAAA 
                   
               
               
                   
                 ATGTGAGCTGGAAAACCAAATTGCACAACTGAATAAAGAGAAAGAATT 
                   
               
               
                   
                 GCTTGTCAAGGAATCTGAAAGCCTGCAGGCCAGACTGAGTGAATCAGA 
                   
               
               
                   
                 TTATGAAAAGCTGAATGTCTCCAAGGCCTTGGAGGCCGCACTGGTGGA 
                   
               
               
                   
                 GAAAGGTGAGTTCGCATTGAGGCTGAGCTCAACACAGGAGGAAGTGCA 
                   
               
               
                   
                 TCAGCTGAGAAGAGGCATCGAGAAACTGAGAGTTCGCATTGAGGCCGA 
                   
               
               
                   
                 TGAAAAGAAGCAGCTGCACATCGCAGAGAAACTGAAAGAACGCGAGC 
                   
               
               
                   
                 GGGAGAATGATTCACTTAAGGATAAAGTTGAGAACCTTGAAAGGGAAT 
                   
               
               
                   
                 TGCAGATGTCAGAAGAAAACCAGGAGCTAGTGATTCTTGATGCCGAGA 
                   
               
               
                   
                 ATTCCAAAGCAGAAGTAGAGACTCTAAAAACACAAATAGAAGAGATGG 
                   
               
               
                   
                 CCAGAAGCCTGAAAGTTTTTGAATTAGACCTTGTCACGTTAAGGTCTGA 
                   
               
               
                   
                 AAAAGAAAATCTGACAAAACAAATACAAGAAAAACAAGGTCAGTTGTC 
                   
               
               
                   
                 AGAACTAGACAAGTTACTCTCTTCATTTAAAAGTCTGTTAGAAGAAAAG 
                   
               
               
                   
                 GAGCAAGCAGAGATACAGATCAAAGAAGAATCTAAAACTGCAGTGGA 
                   
               
               
                   
                 GATGCTTCAGAATCAGTTAAAGGAGCTAAATGAGGCAGTAGCAGCCTT 
                   
               
               
                   
                 GTGTGGTGACCAAGAAATTATGAAGGCCACAGAACAGAGTCTAGACCC 
                   
               
               
                   
                 ACCAATAGAGGAAGAGCATCAGCTGAGAAATAGCATTGAAAAGCTGAG 
                   
               
               
                   
                 AGCCCGCCTAGAAGCTGATGAAAAGAAGCAGCTCTGTGTCTTACAACA 
                   
               
               
                   
                 ACTGAAGGAAAGTGAGCATCATGCAGATTTACTTAAGGGTAGAGTGGA 
                   
               
               
                   
                 GAACCTTGAAAGAGAGCTAGAGATAGCCAGGACAAACCAAGAGCATGC 
                   
               
               
                   
                 AGCTCTTGAGGCAGAGAATTCCAAAGGAGAGGTAGAGACCCTAAAAGC 
                   
               
               
                   
                 AAAAATAGAAGGGATGACCCAAAGTCTGAGAGGTCTGGAATTAGATGT 
                   
               
               
                   
                 TGTTACTATAAGGTCAGAAAAAGAAAATCTGACAAATGAATTACAAAA 
                   
               
               
                   
                 AGAGCAAGAGCGAATATCTGAATTAGAAATAATAAATTCATCATTTGA 
                   
               
               
                   
                 AAATATTTTGCAAGAAAAAGAGCAAGAGAAAGTACAGATGAAAGAAA 
                   
               
               
                   
                 AATCAAGCACTGCCATGGAGATGCTTCAAACACAATTAAAAGAGCTCA 
                   
               
               
                   
                 ATGAGAGAGTGGCAGCCCTGCATAATGACCAAGAAGCCTGTAAGGCCA 
                   
               
               
                   
                 AAGAGCAGAATCTTAGTAGTCAAGTAGAGTGTCTTGAACTTGAGAAGG 
                   
               
               
                   
                 CTCAGTTGCTACAAGGCCTTGATGAGGCCAAAAATAATTATATTGTTTT 
                   
               
               
                   
                 GCAATCTTCAGTGAATGGCCTCATTCAAGAAGTAGAAGATGGCAAGCA 
                   
               
               
                   
                 GAAACTGGAGAAGAAGGATGAAGAAATCAGTAGACTGAAAAATCAAA 
                   
               
               
                   
                 TTCAAGACCAAGAGCAGCTTGTCTCTAAACTGTCCCAGGTGGAAGGAG 
                   
               
               
                   
                 AGCACCAACTTTGGAAGGAGCAAAACTTAGAACTGAGAAATCTGACAG 
                   
               
               
                   
                 TGGAATTGGAGCAGAAGATCCAAGTGCTACAATCCAAAAATGCCTCTTT 
                   
               
               
                   
                 GCAGGACACATTAGAAGTGCTGCAGAGTTCTTACAAGAATCTAGAGAA 
                   
               
               
                   
                 TGAGCTTGAATTGACAAAAATGGACAAAATGTCCTTTGTTGAAAAAGTA 
                   
               
               
                   
                 AACAAAATGACTGCAAAGGAAACTGAGCTGCAGAGGGAAATGCATGA 
                   
               
               
                   
                 GATGGCACAGAAAACAGCAGAGCTGCAAGAAGAACTCAGTGGAGAGA 
                   
               
               
                   
                 AAAATAGGCTAGCTGGAGAGTTGCAGTTACTGTTGGAAGAAATAAAGA 
                   
               
               
                   
                 GCAGCAAAGATCAATTGAAGGAGCTCACACTAGAAAATAGTGAATTGA 
                   
               
               
                   
                 AGAAGAGCCTAGATTGCATGCACAAAGACCAGGTGGAAAAGGAAGGG 
                   
               
               
                   
                 AAAGTGAGAGAGGAAATAGCTGAATATCAGCTACGGCTTCATGAAGCT 
                   
               
               
                   
                 GAAAAGAAACACCAGGCTTTGCTTTTGGACACAAACAAACAGTATGAA 
                   
               
               
                   
                 GTAGAAATCCAGACATACCGAGAGAAATTGACTTCTAAAGAAGAATGT 
                   
               
               
                   
                 CTCAGTTCACAGAAGCTGGAGATAGACCTTTTAAAGTCTAGTAAAGAA 
                   
               
               
                   
                 GAGCTCAATAATTCATTGAAAGCTACTACTCAGATTTTGGAAGAATTGA 
                   
               
               
                   
                 AGAAAACCAAGATGGACAATCTAAAATATGTAAATCAGTTGAAGAAGG 
                   
               
               
                   
                 AAAATGAACGTGCCCAGGGGAAAATGAAGTTGTTGATCAAATCCTGTA 
                   
               
               
                   
                 AACAGCTGGAAGAGGAAAAGGAGATACTGCAGAAAGAACTCTCTCAAC 
                   
               
               
                   
                 TTCAAGCTGCACAGGAGAAGCAGAAAACAGGTACTGTTATGGATACCA 
                   
               
               
                   
                 AGGTCGATGAATTAACAACTGAGATCAAAGAACTGAAAGAAACTCTTG 
                   
               
               
                   
                 AAGAAAAAACCAAGGAGGCAGATGAATACTTGGATAAGTACTGTTCCT 
                   
               
               
                   
                 TGCTTATAAGCCATGAAAAGTTAGAGAAAGCTAAAGAGATGTTAGAGA 
                   
               
               
                   
                 CACAAGTGGCCCATCTGTGTTCACAGCAATCTAAACAAGATTCCCGAGG 
                   
               
               
                   
                 GTCTCCTTTGCTAGGTCCAGTTGTTCCAGGACCATCTCCAATCCCTTCTG 
                   
               
               
                   
                 TTACTGAAAAGAGGTTATCATCTGGCCAAAATAAAGCTTCAGGCAAGA 
                   
               
               
                   
                 GGCAAAGATCCAGTGGAATATGGGAGAATGGTAGAGGACCAACACCTG 
                   
               
               
                   
                 CTACCCCAGAGAGCTTTTCTAAAAAAAGCAAGAAAGCAGTCATGAGTG 
                   
               
               
                   
                 GTATTCACCCTGCAGAAGACACGGAAGGTACTGAGTTTGAGCCAGAGG 
                   
               
               
                   
                 GACTTCCAGAAGTTGTAAAGAAAGGGTTTGCTGACATCCCGACAGGAA 
                   
               
               
                   
                 AGACTAGCCCATATATCCTGCGAAGAACAACCATGGCAACTCGGACCA 
                   
               
               
                   
                 GCCCCCGCCTGGCTGCACAGAAGTTAGCGCTATCCCCACTGAGTCTCGG 
                   
               
               
                   
                 CAAAGAAAATCTTGCAGAGTCCTCCAAACCAACAGCTGGTGGCAGCAG 
                   
               
               
                   
                 ATCACAAAAGGTCAAAGTTGCTCAGCGGAGCCCAGTAGATTCAGGCAC 
                   
               
               
                   
                 CATCCTCCGAGAACCCACCACGAAATCCGTCCCAGTCAATAATCTTCCT 
                   
               
               
                   
                 GAGAGAAGTCCGACTGACAGCCCCAGAGAGGGCCTGAGGGTCAAGCGA 
                   
               
               
                   
                 GGCCGACTTGTCCCCAGCCCCAAAGCTGGACTGGAGTCCAACGGCAGT 
                   
               
               
                   
                 GAGAACTGTAAGGTCCAGTGAAGGCACTTTGTGTGTCAGTACCCCTGGG 
                   
               
               
                   
                 AGGTGCCAGTCATTGAATAGATAAGGCTGTGCCTACAGGACTTCTCTTT 
                   
               
               
                   
                 AGTCAGGGCATGCTTTATTAGTGAGGAGAAAACAATTCCTTAGAAGTCT 
                   
               
               
                   
                 TAAATATATTGTACTCTTTAGATCTCCCATGTGTAGGTATTGAAAAAGTT 
                   
               
               
                   
                 TGGAAGCACTGATCACCTGTTAGCATTGCCATTCCTCTACTGCAATGTA 
                   
               
               
                   
                 AATAGTATAAAGCTATGTATATAAAGCTTTTTGGTAATATGTTACAATT 
                   
               
               
                   
                 AAAATGACAAGCACTATATCACAATCTCTGTTTGTATGTGGGTTTTACA 
                   
               
               
                   
                 CTAAAAAAATGCAAAACACATTTTATTCTTCTAATTAACAGCTCCTAGG 
                   
               
               
                   
                 AAAATGTAGACTTTTGCTTTATGATATTCTATCTGTAGTATGAGGCATG 
                   
               
               
                   
                 GAATAGTTTTGTATCGGGAATTTCTCAGAGCTGAGTAAAATGAAGGAA 
                   
               
               
                   
                 AAGCATGTTATGTGTTTTTAAGGAAAATGTGCACACATATACATGTAGG 
                   
               
               
                   
                 AGTGTTTATCTTTCTCTTACAATCTGTTTTAGACATCTTTGCTTATGAAA 
                   
               
               
                   
                 CCTGTACATATGTGTGTGTGGGTATGTGTTTATTTCCAGTGAGGGCTGC 
                   
               
               
                   
                 AGGCTTCCTAGAGGTGTGCTATACCATGCGTCTGTCGTTGTGCTTTTTTC 
                   
               
               
                   
                 TGTTTTTAGACCAATTTTTTACAGTTCTTTGGTAAGCATTGTCGTATCTG 
                   
               
               
                   
                 GTGATGGATTAACATATAGCCTTTGTTTTCTAATAAAATAGTCGCCTTCG 
                   
               
               
                   
                 TTTTCTGTAAAAAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 AB091343 
                 GGCACGAGGGGCCGACGCGAGCGCCGCGCTTCGCTTCAGCTGCTAGCT 
                 161 
               
               
                   
                 GGCCCAAGGGAGGCGACCGCGGAGGGTGGCGAGGGGCGGCCAGGACC 
                   
               
               
                   
                 CGCAGCCCCGGGGCCGGGCCGGTCCGGACCGCCAGGGAGGGCAGGTCA 
                   
               
               
                   
                 GTGGGCAGATCGCGTCCGCGGGATTCAATCTCTGCCCGCTCTGATAACA 
                   
               
               
                   
                 GTCCTTTTCCCTGGCGCTCACTTCGTGCCTGGCACCCGGCTGGGCGCCTC 
                   
               
               
                   
                 AAGACCGTTGTCTCTTCGATCGCTTCTTTGGACTTGGCGACCATTTCAGA 
                   
               
               
                   
                 GATGTCTTCCAGAAGTACCAAAGATTTAATTAAAAGTAAGTGGGGATC 
                   
               
               
                   
                 GAAGCCTAGTAACTCCAAATCCGAAACTACATTAGAAAAATTAAAGGG 
                   
               
               
                   
                 AGAAATTGCACACTTAAAGACATCAGTGGATGAAATCACAAGTGGGAA 
                   
               
               
                   
                 AGGAAAGCTGACTGATAAAGAGAGACACAGACTTTTGGAGAAAATTCG 
                   
               
               
                   
                 AGTCCTTGAGGCTGAGAAGGAGAAGAATGCTTATCAACTCACAGAGAA 
                   
               
               
                   
                 GGACAAAGAAATACAGCGACTGAGAGACCAACTGAAGGCCAGATATA 
                   
               
               
                   
                 GTACTACCGCATTGCTTGAACAGCTGGAAGAGACAACGAGAGAAGGAG 
                   
               
               
                   
                 AAAGGAGGGAGCAGGTGTTGAAAGCCTTATCTGAAGAGAAAGACGTAT 
                   
               
               
                   
                 TGAAACAACAGTTGTCTGCTGCAACCTCACGAATTGCTGAACTTGAAAG 
                   
               
               
                   
                 CAAAACCAATACACTCCGTTTATCACAGACTGTGGCTCCAAACTGCTTC 
                   
               
               
                   
                 AACTCATCAATAAATAATATTCATGAAATGGAAATACAGCTGAAAGAT 
                   
               
               
                   
                 GCTCTGGAGAAAAATCAGCAGTGGCTCGTGTATGATCAGCAGCGGGAA 
                   
               
               
                   
                 GTCTATGTAAAAGGACTTTTAGCAAAGATCTTTGAGTTGGAAAAGAAA 
                   
               
               
                   
                 ACGGAAACAGCTGCTCATTCACTCCCACAGCAGACAAAAAAGCCTGAA 
                   
               
               
                   
                 TCAGAAGGTTATCTTCAAGAAGAGAAGCAGAAATGTTACAACGATCTC 
                   
               
               
                   
                 TTGGCAAGTGCAAAAAAAGATCTTGAGGTTGAACGACAAACCATAACT 
                   
               
               
                   
                 CAGCTGAGTTTTGAACTGAGTGAATTTCGAAGAAAATATGAAGAAACC 
                   
               
               
                   
                 CAAAAAGAAGTTCACAATTTAAATCAGCTGTTGTATTCACAAAGAAGG 
                   
               
               
                   
                 GCAGATGTGCAACATCTGGAAGATGATAGGCATAAAACAGAGAAGATA 
                   
               
               
                   
                 CAAAAACTCAGGGAAGAGAATGATATTGCTAGGGGAAAACTTGAAGAA 
                   
               
               
                   
                 GAGAAGAAGAGATCCGAAGAGCTCTTATCTCAGGTCCAGTTTCTTTACA 
                   
               
               
                   
                 CATCTCTGCTAAAGCAGCAAGAAGAACAAACAAGGGTAGCTCTGTTGG 
                   
               
               
                   
                 AACAACAGATGCAGGCATGTACTTTAGACTTTGAAAATGAAAAACTCG 
                   
               
               
                   
                 ACCGTCAACATGTGCAGCATCAATTGCATGTAATTCTTAAGGAGCTCCG 
                   
               
               
                   
                 AAAAGCAAGAAATCAAATAACACAGTTGGAATCCTTGAAACAGCTTCA 
                   
               
               
                   
                 TGAGTTTGCCATCACAGAGCCATTAGTCACTTTCCAAGGAGAGACTGAA 
                   
               
               
                   
                 AACAGAGAAAAAGTTGCCGCCTCACCAAAAAGTCCCACTGCTGCACTC 
                   
               
               
                   
                 AATGAAAGCCTGGTGGAATGTCCCAAGTGCAATATACAGTATCCAGCC 
                   
               
               
                   
                 ACTGAGCATCGCGATCTGCTTGTCCATGTGGAATACTGTTCAAAGTAGC 
                   
               
               
                   
                 AAAATAAGTATTTGTTTTGATATTAAAAGATTCAATACTGTATTTTCTGT 
                   
               
               
                   
                 TAGCTTGTGGGCATTTTGAATTATATATTTCACATTTTGCATAAAACTGC 
                   
               
               
                   
                 CTATCTACCTTTGACACTCCAGCATGCTAGTGAATCATGTATCTTTTAGG 
                   
               
               
                   
                 CTGCTGTGCATTTCTCTTGGCAGTGATACCTCCCTGACATGGTTCATCAT 
                   
               
               
                   
                 CAGGCTGCAATGACAGAATGTGGTGAGCAGCGTCTACTGAGACTACTA 
                   
               
               
                   
                 ACATTTTGCACTGTCAAAATACTTGGTGAGGAAAAGATAGCTCAGGTTA 
                   
               
               
                   
                 TTGCTAATGGGTTAATGCACCAGCAAGCAAAATATTTTATGTTTTGGGG 
                   
               
               
                   
                 GTTTGAAAAATCAAAGATAATTAACCAAGGATCTTAACTGTGTTCGCAT 
                   
               
               
                   
                 TTTTTATCCAAGCACTTAGAAAACCTACAATCCTAATTTTGATGTCCATT 
                   
               
               
                   
                 GTTAAGAGGTGGTGATAGATACTATTTTTTTTTTCATATTGTATAGCGGT 
                   
               
               
                   
                 TATTAGAAAAGTTGGGGATTTTCTTGATCTTTATTGCTGCTTACCATTGA 
                   
               
               
                   
                 AACTTAACCCAGCTGTGTTCCCCAACTCTGTTCTGCGCACGAAACAGTA 
                   
               
               
                   
                 TCTGTTTGAGGCATAATCTTAAGTGGCCACACACAATGTTTTCTCTTATG 
                   
               
               
                   
                 TTATCTGGCAGTAACTGTAACTTGAATTACATTAGCACATTCTGCTTAGC 
                   
               
               
                   
                 TAAAATTGTTAAAATAAACTTTAATAAACCCATGTAGCCCTCTCATTTG 
                   
               
               
                   
                 ATTGACAGTATTTTAGTTATTTTTGGCATTCTTAAAGCTGGGCAATGTAA 
                   
               
               
                   
                 TGATCAGATCTTTGTTTGTCTGAACAGGTATTTTTATACATGCTTTTTGT 
                   
               
               
                   
                 AAACCAAAAACTTTTAAATTTCTTCAGGTTTTCTAACATGCTTACCACTG 
                   
               
               
                   
                 GGCTACTGTAAATGAGAAAAGAATAAAATTATTTAATGTTTTAAAAAA 
                   
               
               
                   
                 AAAAAAAAA 
                   
               
               
                   
               
               
                 BC006428 
                 GGCGGCTGAGCCTGAGCGGGGATGTAGAGGCGGCGGCAGCAGAGGCG 
                 162 
               
               
                   
                 GCACTGGCGGCAAGAGCAGACGCCCGAGCCGAGCGAGAAGAGCGGCA 
                   
               
               
                   
                 GAGCCTTATCCCCTGAAGCCGGGCCCCGCGTCCCAGCCCTGCCCAGCCC 
                   
               
               
                   
                 GCGCCCAGCCATGCGCGCCGCCTGCTGAGTCCGGGCGCCGCACGCTGA 
                   
               
               
                   
                 GCCCTCCGCCCGCGAGCCGCGCTCAGCTCGGGGGTGATTAGTTGCTTTT 
                   
               
               
                   
                 TGTTGTTTTTTAATTTGGGCCGCGGGGAGGGGGAGGAGGGGCAGGTGCT 
                   
               
               
                   
                 GCAGGCTCCCCCCCCTCCCCGCCTCGGGCCAGCCGCGGCGGCGCGACTC 
                   
               
               
                   
                 GGGCTCCGGACCCGGGCACTGCTGGCGGCTGGAGCGGAGCGCACCGCG 
                   
               
               
                   
                 GCGGTGGTGCCCAGAGCGGAGCGCAGCTCCCTGCCCCGCCCCTCCCCCT 
                   
               
               
                   
                 CGGCCTCGCGGCGACGGCGGCGGTGGCGGCTTGGACGACTCGGAGAGC 
                   
               
               
                   
                 CGAGTGAAGACATTTCCACCTGGACACCTGACCATGTGCCTGCCCTGAG 
                   
               
               
                   
                 CAGCGAGGCCCACCAGGCATCTCTGTTGTGGGCAGCAGGGCCAGGTCC 
                   
               
               
                   
                 TGGTCTGTGGACCCTCGGCAGTTGGCAGGCTCCCTCTGCAGTGGGGTCT 
                   
               
               
                   
                 GGGCCTCGGCCCCACCATGTCGAGCCTCGGCGGTGGCTCCCAGGATGCC 
                   
               
               
                   
                 GGCGGCAGTAGCAGCAGCAGCACCAATGGCAGCGGTGGCAGTGGCAGC 
                   
               
               
                   
                 AGTGGCCCAAAGGCAGGAGCAGCAGACAAGAGTGCAGTGGTGGCTGCC 
                   
               
               
                   
                 GCCGCACCAGCCTCAGTGGCAGATGACACACCACCCCCCGAGCGTCGG 
                   
               
               
                   
                 AACAAGAGCGGTATCATCAGTGAGCCCCTCAACAAGAGCCTGCGCCGC 
                   
               
               
                   
                 TCCCGCCCGCTCTCCCACTACTCTTCTTTTGGCAGCAGTGGTGGTAGTGG 
                   
               
               
                   
                 CGGTGGCAGCATGATGGGCGGAGAGTCTGCTGACAAGGCCACTGCGGC 
                   
               
               
                   
                 TGCAGCCGCTGCCTCCCTGTTGGCCAATGGGCATGACCTGGCGGCGGCC 
                   
               
               
                   
                 ATGGCGGTGGACAAAAGCAACCCTACCTCAAAGCACAAAAGTGGTGCT 
                   
               
               
                   
                 GTGGCCAGCCTGCTGAGCAAGGCAGAGCGGGCCACGGAGCTGGCAGCC 
                   
               
               
                   
                 GAGGGACAGCTGACGCTGCAGCAGTTTGCGCAGTCCACAGAGATGCTG 
                   
               
               
                   
                 AAGCGCGTGGTGCAGGAGCATCTCCCGCTGATGAGCGAGGCGGGTGCT 
                   
               
               
                   
                 GGCCTGCCTGACATGGAGGCTGTGGCAGGTGCCGAAGCCCTCAATGGC 
                   
               
               
                   
                 CAGTCCGACTTCCCCTACCTGGGCGCTTTCCCCATCAACCCAGGCCTCTT 
                   
               
               
                   
                 CATTATGACCCCGGCAGGTGTGTTCCTGGCCGAGAGCGCGCTGCACATG 
                   
               
               
                   
                 GCGGGCCTGGCTGAGTACCCCATGCAGGGAGAGCTGGCCTCTGCCATC 
                   
               
               
                   
                 AGCTCCGGCAAGAAGAAGCGGAAACGCTGCGGCATGTGCGCGCCCTGC 
                   
               
               
                   
                 CGGCGGCGCATCAACTGCGAGCAGTGCAGCAGTTGTAGGAATCGAAAG 
                   
               
               
                   
                 ACTGGCCATCAGATTTGCAAATTCAGAAAATGTGAGGAACTCAAAAAG 
                   
               
               
                   
                 AAGCCTTCCGCTGCTCTGGAGAAGGTGATGCTTCCGACGGGAGCCGCCT 
                   
               
               
                   
                 TCCGGTGGTTTCAGTGACGGCGGCGGAACCCAAAGCTGCCCTCTCCGTG 
                   
               
               
                   
                 CAATGTCACTGCTCGTGTGGTCTCCAGCAAGGGATTCGGGCGAAGACA 
                   
               
               
                   
                 AACGGATGCACCCGTCTTTAGAACCAAAAATATTCTCTCACAGATTTCA 
                   
               
               
                   
                 TTCCTGTTTTTATATATATATTTTTTGTTGTCGTTTTAACATCTCCACGTC 
                   
               
               
                   
                 CCTAGCATAAAAAGAAAAAGAAAAAAATTTAAACTGCTTTTTCGGAAG 
                   
               
               
                   
                 AACAACAACAAAAAAGAGGTAAAGACGAATCTATAAAGTACCGAGACT 
                   
               
               
                   
                 TCCTGGGCAAAGAATGGACAATCAGTTTCCTTCCTGTGTCGATGTCGAT 
                   
               
               
                   
                 GTTGTCTGTGCAGGAGATGCAGTTTTTGTGTAGAGAATGTAAATTTTCT 
                   
               
               
                   
                 GTAACCTTTTGAAATCTAGTTACTAATAAGCACTACTGTAATTTAGCAC 
                   
               
               
                   
                 AGTTTAACTCCACCCTCATTTAAACTTCCTTTGATTCTTTCCGACCATGA 
                   
               
               
                   
                 AATAGTGCATAGTTTGCCTGGAGAATCCACTCACGTTCATAAAGAGAAT 
                   
               
               
                   
                 GTTGATGGCGCCGTGTAGAAGCCGCTCTGTATCCATCCACGCGTGCAGA 
                   
               
               
                   
                 GCTGCCAGCAGGGAGCTCACAGAAGGGGAGGGAGCACCAGGCCAGCT 
                   
               
               
                   
                 GAGCTGCACCCACAGTCCCGAGACTGGGATCCCCCACCCCAACAGTGA 
                   
               
               
                   
                 TTTTGGAAAAAAAAATGAAAGTTCTGTTCGTTTATCCATTGCGATCTGG 
                   
               
               
                   
                 GGAGCCCCATCTCGATATTTCCAATCCTGGCTACTTTTCTTAGAGAAAA 
                   
               
               
                   
                 TAAGTCCTTTTTTTCTGGCCTTGCTAATGGCAACAGAAGAAAGGGCTTC 
                   
               
               
                   
                 TTTGCGTGGTCCCCTGCTGGTGGGGGTGGGTCCCCAGGGGGCCCCCTGC 
                   
               
               
                   
                 GGCCTGGGCCCCCCTGCCCACGGCCAGCTTCCTGCTGATGAACATGCTG 
                   
               
               
                   
                 TTTGTATTGTTTTAGGAAACCAGGCTGTTTTGTGAATAAAACGAATGCA 
                   
               
               
                   
                 TGTTTGTGTCACGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
                 AAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_005228 
                 CCCCGGCGCAGCGCGGCCGCAGCAGCCTCCGCCCCCCGCACGGTGTGA 
                 163 
               
               
                   
                 GCGCCCGACGCGGCCGAGGCGGCCGGAGTCCCGAGCTAGCCCCGGCGG 
                   
               
               
                   
                 CCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCC 
                   
               
               
                   
                 GAGTCCCCGCCTCGCCGCCAACGCCACAACCACCGCGCACGGCCCCCTG 
                   
               
               
                   
                 ACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAG 
                   
               
               
                   
                 CAGCGATGCGACCCTCCGGGACGGCCGGGGCAGCGCTCCTGGCGCTGC 
                   
               
               
                   
                 TGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTT 
                   
               
               
                   
                 GCCAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATC 
                   
               
               
                   
                 ATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTCCTTGG 
                   
               
               
                   
                 GAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTA 
                   
               
               
                   
                 AAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACACAG 
                   
               
               
                   
                 TGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGT 
                   
               
               
                   
                 ACTACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACTATGATGCAAA 
                   
               
               
                   
                 TAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAAATCCT 
                   
               
               
                   
                 GCATGGCGCCGTGCGGTTCAGCAACAACCCTGCCCTGTGCAACGTGGA 
                   
               
               
                   
                 GAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTTCTCAGCAACAT 
                   
               
               
                   
                 GTCGATGGACTTCCAGAACCACCTGGGCAGCTGCCAAAAGTGTGATCC 
                   
               
               
                   
                 AAGCTGTCCCAATGGGAGCTGCTGGGGTGCAGGAGAGGAGAACTGCCA 
                   
               
               
                   
                 GAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGT 
                   
               
               
                   
                 GGCAAGTCCCCCAGTGACTGCTGCCACAACCAGTGTGCTGCAGGCTGCA 
                   
               
               
                   
                 CAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACG 
                   
               
               
                   
                 AAGCCACGTGCAAGGACACCTGCCCCCCACTCATGCTCTACAACCCCAC 
                   
               
               
                   
                 CACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGC 
                   
               
               
                   
                 CACCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGC 
                   
               
               
                   
                 TCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGAC 
                   
               
               
                   
                 GGCGTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGT 
                   
               
               
                   
                 AACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAATGCTA 
                   
               
               
                   
                 CGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCA 
                   
               
               
                   
                 CATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACACATACTCCTCCTC 
                   
               
               
                   
                 TGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAG 
                   
               
               
                   
                 GGTTTTTGCTGATTCAGGCTTGGCCTGAAAACAGGACGGACCTCCATGC 
                   
               
               
                   
                 CTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCA 
                   
               
               
                   
                 GTTTTCTCTTGCAGTCGTCAGCCTGAACATAACATCCTTGGGATTACGCT 
                   
               
               
                   
                 CCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAA 
                   
               
               
                   
                 ATTTGTGCTATGCAAATACAATAAACTGGAAAAAACTGTTTGGGACCTC 
                   
               
               
                   
                 CGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAA 
                   
               
               
                   
                 GGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGG 
                   
               
               
                   
                 GGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGC 
                   
               
               
                   
                 AGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAG 
                   
               
               
                   
                 TTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGCCTGCCTC 
                   
               
               
                   
                 AGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCC 
                   
               
               
                   
                 AGTGTGCCCACTACATTGACGGCCCCCACTGCGTCAAGACCTGCCCGGC 
                   
               
               
                   
                 AGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGC 
                   
               
               
                   
                 CGGCCATGTGTGCCACCTGTGCCATCCAAACTGCACCTACGGATGCACT 
                   
               
               
                   
                 GGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCC 
                   
               
               
                   
                 ATCGCCACTGGGATGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCCC 
                   
               
               
                   
                 TGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCAC 
                   
               
               
                   
                 GCTGCGGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACC 
                   
               
               
                   
                 CAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAAC 
                   
               
               
                   
                 TGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGT 
                   
               
               
                   
                 GTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGT 
                   
               
               
                   
                 CGCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGA 
                   
               
               
                   
                 AATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCCCACGT 
                   
               
               
                   
                 GTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACG 
                   
               
               
                   
                 CAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTCCGGGAACACAAAG 
                   
               
               
                   
                 ACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAA 
                   
               
               
                   
                 GGGCATGAACTACTTGGAGGACCGTCGCTTGGTGCACCGCGACCTGGC 
                   
               
               
                   
                 AGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGA 
                   
               
               
                   
                 TTTTGGGCTGGCCAAACTGCTGGGTGCGGAAGAGAAAGAATACCATGC 
                   
               
               
                   
                 AGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTT 
                   
               
               
                   
                 ACACAGAATCTATACCCACCAGAGTGATGTCTGGAGCTACGGGGTGAC 
                   
               
               
                   
                 CGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCT 
                   
               
               
                   
                 GCCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAG 
                   
               
               
                   
                 CCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGA 
                   
               
               
                   
                 TGATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATT 
                   
               
               
                   
                 CTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAGGGGGAT 
                   
               
               
                   
                 GAAAGAATGCATTTGCCAAGTCCTACAGACTCCAACTTCTACCGTGCCC 
                   
               
               
                   
                 TGATGGATGAAGAAGACATGGACGACGTGGTGGATGCCGACGAGTACC 
                   
               
               
                   
                 TCATCCCACAGCAGGGCTTCTTCAGCAGCCCCTCCACGTCACGGACTCC 
                   
               
               
                   
                 CCTCCTGAGCTCTCTGAGTGCAACCAGCAACAATTCCACCGTGGCTTGC 
                   
               
               
                   
                 ATTGATAGAAATGGGCTGCAAAGCTGTCCCATCAAGGAAGACAGCTTC 
                   
               
               
                   
                 TTGCAGCGATACAGCTCAGACCCCACAGGCGCCTTGACTGAGGACAGC 
                   
               
               
                   
                 ATAGACGACACCTTCCTCCCAGTGCCTGAATACATAAACCAGTCCGTTC 
                   
               
               
                   
                 CCAAAAGGCCCGCTGGCTCTGTGCAGAATCCTGTCTATCACAATCAGCC 
                   
               
               
                   
                 TCTGAACCCCGCGCCCAGCAGAGACCCACACTACCAGGACCCCCACAG 
                   
               
               
                   
                 CACTGCAGTGGGCAACCCCGAGTATCTCAACACTGTCCAGCCCACCTGT 
                   
               
               
                   
                 GTCAACAGCACATTCGACAGCCCTGCCCACTGGGCCCAGAAAGGCAGC 
                   
               
               
                   
                 CACCAAATTAGCCTGGACAACCCTGACTACCAGCAGGACTTCTTTCCCA 
                   
               
               
                   
                 AGGAAGCCAAGCCAAATGGCATCTTTAAGGGCTCCACAGCTGAAAATG 
                   
               
               
                   
                 CAGAATACCTAAGGGTCGCGCCACAAAGCAGTGAATTTATTGGAGCAT 
                   
               
               
                   
                 GACCACGGAGGATAGTATGAGCCCTAAAAATCCAGACTCTTTCGATACC 
                   
               
               
                   
                 CAGGACCAAGCCACAGCAGGTCCTCCATCCCAACAGCCATGCCCGCATT 
                   
               
               
                   
                 AGCTCTTAGACCCACAGACTGGTTTTGCAACGTTTACACCGACTAGCCA 
                   
               
               
                   
                 GGAAGTACTTCCACCTCGGGCACATTTTGGGAAGTTGCATTCCTTTGTCT 
                   
               
               
                   
                 TCAAACTGTGAAGCATTTACAGAAACGCATCCAGCAAGAATATTGTCCC 
                   
               
               
                   
                 TTTGAGCAGAAATTTATCTTTCAAAGAGGTATATTTGAAAAAAAAAAAA 
                   
               
               
                   
                 AGTATATGTGAGGATTTTTATTGATTGGGGATCTTGGAGTTTTTCATTGT 
                   
               
               
                   
                 CGCTATTGATTTTTACTTCAATGGGCTCTTCCAACAAGGAAGAAGCTTG 
                   
               
               
                   
                 CTGGTAGCACTTGCTACCCTGAGTTCATCCAGGCCCAACTGTGAGCAAG 
                   
               
               
                   
                 GAGCACAAGCCACAAGTCTTCCAGAGGATGCTTGATTCCAGTGGTTCTG 
                   
               
               
                   
                 CTTCAAGGCTTCCACTGCAAAACACTAAAGATCCAAGAAGGCCTTCATG 
                   
               
               
                   
                 GCCCCAGCAGGCCGGATCGGTACTGTATCAAGTCATGGCAGGTACAGT 
                   
               
               
                   
                 AGGATAAGCCACTCTGTCCCTTCCTGGGCAAAGAAGAAACGGAGGGGA 
                   
               
               
                   
                 TGGAATTCTTCCTTAGACTTACTTTTGTAAAAATGTCCCCACGGTACTTA 
                   
               
               
                   
                 CTCCCCACTGATGGACCAGTGGTTTCCAGTCATGAGCGTTAGACTGACT 
                   
               
               
                   
                 TGTTTGTCTTCCATTCCATTGTTTTGAAACTCAGTATGCTGCCCCTGTCTT 
                   
               
               
                   
                 GCTGTCATGAAATCAGCAAGAGAGGATGACACATCAAATAATAACTCG 
                   
               
               
                   
                 GATTCCAGCCCACATTGGATTCATCAGCATTTGGACCAATAGCCCACAG 
                   
               
               
                   
                 CTGAGAATGTGGAATACCTAAGGATAGCACCGCTTTTGTTCTCGCAAAA 
                   
               
               
                   
                 ACGTATCTCCTAATTTGAGGCTCAGATGAAATGCATCAGGTCCTTTGGG 
                   
               
               
                   
                 GCATAGATCAGAAGACTACAAAAATGAAGCTGCTCTGAAATCTCCTTTA 
                   
               
               
                   
                 GCCATCACCCCAACCCCCCAAAATTAGTTTGTGTTACTTATGGAAGATA 
                   
               
               
                   
                 GTTTTCTCCTTTTACTTCACTTCAAAAGCTTTTTACTCAAAGAGTATATG 
                   
               
               
                   
                 TTCCCTCCAGGTCAGCTGCCCCCAAACCCCCTCCTTACGCTTTGTCACAC 
                   
               
               
                   
                 AAAAAGTGTCTCTGCCTTGAGTCATCTATTCAAGCACTTACAGCTCTGG 
                   
               
               
                   
                 CCACAACAGGGCATTTTACAGGTGCGAATGACAGTAGCATTATGAGTA 
                   
               
               
                   
                 GTGTGGAATTCAGGTAGTAAATATGAAACTAGGGTTTGAAATTGATAAT 
                   
               
               
                   
                 GCTTTCACAACATTTGCAGATGTTTTAGAAGGAAAAAAGTTCCTTCCTA 
                   
               
               
                   
                 AAATAATTTCTCTACAATTGGAAGATTGGAAGATTCAGCTAGTTAGGAG 
                   
               
               
                   
                 CCCACCTTTTTTCCTAATCTGTGTGTGCCCTGTAACCTGACTGGTTAACA 
                   
               
               
                   
                 GCAGTCCTTTGTAAACAGTGTTTTAAACTCTCCTAGTCAATATCCACCCC 
                   
               
               
                   
                 ATCCAATTTATCAAGGAAGAAATGGTTCAGAAAATATTTTCAGCCTACA 
                   
               
               
                   
                 GTTATGTTCAGTCACACACACATACAAAATGTTCCTTTTGCTTTTAAAGT 
                   
               
               
                   
                 AATTTTTGACTCCCAGATCAGTCAGAGCCCCTACAGCATTGTTAAGAAA 
                   
               
               
                   
                 GTATTTGATTTTTGTCTCAATGAAAATAAAACTATATTCATTTCCACTCT 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_001005862 
                 GTTCCCGGATTTTTGTGGGCGCCTGCCCCGCCCCTCGTCCCCCTGCTGTG 
                 164 
               
               
                   
                 TCCATATATCGAGGCGATAGGGTTAAGGGAAGGCGGACGCCTGATGGG 
                   
               
               
                   
                 TTAATGAGCAAACTGAAGTGTTTTCCATGATCTTTTTTGAGTCGCAATTG 
                   
               
               
                   
                 AAGTACCACCTCCCGAGGGTGATTGCTTCCCCATGCGGGGTAGAACCTT 
                   
               
               
                   
                 TGCTGTCCTGTTCACCACTCTACCTCCAGCACAGAATTTGGCTTATGCCT 
                   
               
               
                   
                 ACTCAATGTGAAGATGATGAGGATGAAAACCTTTGTGATGATCCACTTC 
                   
               
               
                   
                 CACTTAATGAATGGTGGCAAAGCAAAGCTATATTCAAGACCACATGCA 
                   
               
               
                   
                 AAGCTACTCCCTGAGCAAAGAGTCACAGATAAAACGGGGGCACCAGTA 
                   
               
               
                   
                 GAATGGCCAGGACAAACGCAGTGCAGCACAGAGACTCAGACCCTGGCA 
                   
               
               
                   
                 GCCATGCCTGCGCAGGCAGTGATGAGAGTGACATGTACTGTTGTGGAC 
                   
               
               
                   
                 ATGCACAAAAGTGAGTGTGCACCGGCACAGACATGAAGCTGCGGCTCC 
                   
               
               
                   
                 CTGCCAGTCCCGAGACCCACCTGGACATGCTCCGCCACCTCTACCAGGG 
                   
               
               
                   
                 CTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCTGCCCACCAAT 
                   
               
               
                   
                 GCCAGCCTGTCCTTCCTGCAGGATATCCAGGAGGTGCAGGGCTACGTGC 
                   
               
               
                   
                 TCATCGCTCACAACCAAGTGAGGCAGGTCCCACTGCAGAGGCTGCGGA 
                   
               
               
                   
                 TTGTGCGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCT 
                   
               
               
                   
                 AGACAATGGAGACCCGCTGAACAATACCACCCCTGTCACAGGGGCCTC 
                   
               
               
                   
                 CCCAGGAGGCCTGCGGGAGCTGCAGCTTCGAAGCCTCACAGAGATCTT 
                   
               
               
                   
                 GAAAGGAGGGGTCTTGATCCAGCGGAACCCCCAGCTCTGCTACCAGGA 
                   
               
               
                   
                 CACGATTTTGTGGAAGGACATCTTCCACAAGAACAACCAGCTGGCTCTC 
                   
               
               
                   
                 ACACTGATAGACACCAACCGCTCTCGGGCCTGCCACCCCTGTTCTCCGA 
                   
               
               
                   
                 TGTGTAAGGGCTCCCGCTGCTGGGGAGAGAGTTCTGAGGATTGTCAGA 
                   
               
               
                   
                 GCCTGACGCGCACTGTCTGTGCCGGTGGCTGTGCCCGCTGCAAGGGGCC 
                   
               
               
                   
                 ACTGCCCACTGACTGCTGCCATGAGCAGTGTGCTGCCGGCTGCACGGGC 
                   
               
               
                   
                 CCCAAGCACTCTGACTGCCTGGCCTGCCTCCACTTCAACCACAGTGGCA 
                   
               
               
                   
                 TCTGTGAGCTGCACTGCCCAGCCCTGGTCACCTACAACACAGACACGTT 
                   
               
               
                   
                 TGAGTCCATGCCCAATCCCGAGGGCCGGTATACATTCGGCGCCAGCTGT 
                   
               
               
                   
                 GTGACTGCCTGTCCCTACAACTACCTTTCTACGGACGTGGGATCCTGCA 
                   
               
               
                   
                 CCCTCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCAGAGGATGGAA 
                   
               
               
                   
                 CACAGCGGTGTGAGAAGTGCAGCAAGCCCTGTGCCCGAGTGTGCTATG 
                   
               
               
                   
                 GTCTGGGCATGGAGCACTTGCGAGAGGTGAGGGCAGTTACCAGTGCCA 
                   
               
               
                   
                 ATATCCAGGAGTTTGCTGGCTGCAAGAAGATCTTTGGGAGCCTGGCATT 
                   
               
               
                   
                 TCTGCCGGAGAGCTTTGATGGGGACCCAGCCTCCAACACTGCCCCGCTC 
                   
               
               
                   
                 CAGCCAGAGCAGCTCCAAGTGTTTGAGACTCTGGAAGAGATCACAGGT 
                   
               
               
                   
                 TACCTATACATCTCAGCATGGCCGGACAGCCTGCCTGACCTCAGCGTCT 
                   
               
               
                   
                 TCCAGAACCTGCAAGTAATCCGGGGACGAATTCTGCACAATGGCGCCT 
                   
               
               
                   
                 ACTCGCTGACCCTGCAAGGGCTGGGCATCAGCTGGCTGGGGCTGCGCTC 
                   
               
               
                   
                 ACTGAGGGAACTGGGCAGTGGACTGGCCCTCATCCACCATAACACCCA 
                   
               
               
                   
                 CCTCTGCTTCGTGCACACGGTGCCCTGGGACCAGCTCTTTCGGAACCCG 
                   
               
               
                   
                 CACCAAGCTCTGCTCCACACTGCCAACCGGCCAGAGGACGAGTGTGTG 
                   
               
               
                   
                 GGCGAGGGCCTGGCCTGCCACCAGCTGTGCGCCCGAGGGCACTGCTGG 
                   
               
               
                   
                 GGTCCAGGGCCCACCCAGTGTGTCAACTGCAGCCAGTTCCTTCGGGGCC 
                   
               
               
                   
                 AGGAGTGCGTGGAGGAATGCCGAGTACTGCAGGGGCTCCCCAGGGAGT 
                   
               
               
                   
                 ATGTGAATGCCAGGCACTGTTTGCCGTGCCACCCTGAGTGTCAGCCCCA 
                   
               
               
                   
                 GAATGGCTCAGTGACCTGTTTTGGACCGGAGGCTGACCAGTGTGTGGCC 
                   
               
               
                   
                 TGTGCCCACTATAAGGACCCTCCCTTCTGCGTGGCCCGCTGCCCCAGCG 
                   
               
               
                   
                 GTGTGAAACCTGACCTCTCCTACATGCCCATCTGGAAGTTTCCAGATGA 
                   
               
               
                   
                 GGAGGGCGCATGCCAGCCTTGCCCCATCAACTGCACCCACTCCTGTGTG 
                   
               
               
                   
                 GACCTGGATGACAAGGGCTGCCCCGCCGAGCAGAGAGCCAGCCCTCTG 
                   
               
               
                   
                 ACGTCCATCATCTCTGCGGTGGTTGGCATTCTGCTGGTCGTGGTCTTGGG 
                   
               
               
                   
                 GGTGGTCTTTGGGATCCTCATCAAGCGACGGCAGCAGAAGATCCGGAA 
                   
               
               
                   
                 GTACACGATGCGGAGACTGCTGCAGGAAACGGAGCTGGTGGAGCCGCT 
                   
               
               
                   
                 GACACCTAGCGGAGCGATGCCCAACCAGGCGCAGATGCGGATCCTGAA 
                   
               
               
                   
                 AGAGACGGAGCTGAGGAAGGTGAAGGTGCTTGGATCTGGCGCTTTTGG 
                   
               
               
                   
                 CACAGTCTACAAGGGCATCTGGATCCCTGATGGGGAGAATGTGAAAAT 
                   
               
               
                   
                 TCCAGTGGCCATCAAAGTGTTGAGGGAAAACACATCCCCCAAAGCCAA 
                   
               
               
                   
                 CAAAGAAATCTTAGACGAAGCATACGTGATGGCTGGTGTGGGCTCCCC 
                   
               
               
                   
                 ATATGTCTCCCGCCTTCTGGGCATCTGCCTGACATCCACGGTGCAGCTG 
                   
               
               
                   
                 GTGACACAGCTTATGCCCTATGGCTGCCTCTTAGACCATGTCCGGGAAA 
                   
               
               
                   
                 ACCGCGGACGCCTGGGCTCCCAGGACCTGCTGAACTGGTGTATGCAGAT 
                   
               
               
                   
                 TGCCAAGGGGATGAGCTACCTGGAGGATGTGCGGCTCGTACACAGGGA 
                   
               
               
                   
                 CTTGGCCGCTCGGAACGTGCTGGTCAAGAGTCCCAACCATGTCAAAATT 
                   
               
               
                   
                 ACAGACTTCGGGCTGGCTCGGCTGCTGGACATTGACGAGACAGAGTAC 
                   
               
               
                   
                 CATGCAGATGGGGGCAAGGTGCCCATCAAGTGGATGGCGCTGGAGTCC 
                   
               
               
                   
                 ATTCTCCGCCGGCGGTTCACCCACCAGAGTGATGTGTGGAGTTATGGTG 
                   
               
               
                   
                 TGACTGTGTGGGAGCTGATGACTTTTGGGGCCAAACCTTACGATGGGAT 
                   
               
               
                   
                 CCCAGCCCGGGAGATCCCTGACCTGCTGGAAAAGGGGGAGCGGCTGCC 
                   
               
               
                   
                 CCAGCCCCCCATCTGCACCATTGATGTCTACATGATCATGGTCAAATGT 
                   
               
               
                   
                 TGGATGATTGACTCTGAATGTCGGCCAAGATTCCGGGAGTTGGTGTCTG 
                   
               
               
                   
                 AATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAA 
                   
               
               
                   
                 TGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCTCA 
                   
               
               
                   
                 CTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTAT 
                   
               
               
                   
                 CTGGTACCCCAGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTG 
                   
               
               
                   
                 GGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCG 
                   
               
               
                   
                 GTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCA 
                   
               
               
                   
                 GGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGG 
                   
               
               
                   
                 TGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACA 
                   
               
               
                   
                 TGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCCCTG 
                   
               
               
                   
                 CCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGC 
                   
               
               
                   
                 CTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCG 
                   
               
               
                   
                 AGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGG 
                   
               
               
                   
                 CCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTG 
                   
               
               
                   
                 CCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAG 
                   
               
               
                   
                 GAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGA 
                   
               
               
                   
                 CAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACC 
                   
               
               
                   
                 CAGCACCTTCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGG 
                   
               
               
                   
                 TCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTG 
                   
               
               
                   
                 ATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGA 
                   
               
               
                   
                 GGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCCAGGA 
                   
               
               
                   
                 ACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGA 
                   
               
               
                   
                 AGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTTTGTG 
                   
               
               
                   
                 GATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACA 
                   
               
               
                   
                 GCCCAGCTTGGCCCTTTCCTTCCAGATCCTGGGTACTGAAAGCCTTAGG 
                   
               
               
                   
                 GAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGTCTAAGAACA 
                   
               
               
                   
                 AAAGCGACCCATTCAGAGACTGTCCCTGAAACCTAGTACTGCCCCCCAT 
                   
               
               
                   
                 GAGGAAGGAACAGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGC 
                   
               
               
                   
                 TTTTCTGTTTAGTTTTTACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATA 
                   
               
               
                   
                 AAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGG 
                   
               
               
                   
                 GTCCTTCTCCACACCCACTTTGTCCATTTGCAAATATATTTTGGAAAACA 
                   
               
               
                   
                 GCTA 
                   
               
               
                   
               
               
                 NM_001122742 
                 ATGGTCATAACAGCCTCCTGTCTACCGACTCAGAACGGATTTTACCAAA 
                 165 
               
               
                   
                 ACTGAAAATGCAGGCTCCATGCTCAGAAGCTCTTTAACAGGCTCGAAA 
                   
               
               
                   
                 GGTCCATGCTCCTTTCTCCTGCCCATTCTATAGCATAAGAAGACAGTCTC 
                   
               
               
                   
                 TGAGTGATAATCTTCTCTTCAAGAAGAAGAAAACTAGGAAGGAGTAAG 
                   
               
               
                   
                 CACAAAGATCTCTTCACATTCTCCGGGACTGCGGTACCAAATATCAGCA 
                   
               
               
                   
                 CAGCACTTCTTGAAAAAGGATGTAGATTTTAATCTGAACTTTGAACCAT 
                   
               
               
                   
                 CACTGAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACG 
                   
               
               
                   
                 GTCTGCACCCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACC 
                   
               
               
                   
                 AAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTG 
                   
               
               
                   
                 GAGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGG 
                   
               
               
                   
                 GCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCG 
                   
               
               
                   
                 AGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGG 
                   
               
               
                   
                 TCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGC 
                   
               
               
                   
                 GTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCT 
                   
               
               
                   
                 CCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCC 
                   
               
               
                   
                 TGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCA 
                   
               
               
                   
                 GCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAA 
                   
               
               
                   
                 ATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCA 
                   
               
               
                   
                 ATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACT 
                   
               
               
                   
                 GTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTC 
                   
               
               
                   
                 CTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAA 
                   
               
               
                   
                 CGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAG 
                   
               
               
                   
                 GAGGAAGAGCTGCCAGGCCTGCCGGCTCCGCAAATGCTACGAAGTGGG 
                   
               
               
                   
                 AATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGT 
                   
               
               
                   
                 TGAAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTG 
                   
               
               
                   
                 GGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCA 
                   
               
               
                   
                 TGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGA 
                   
               
               
                   
                 CCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCCATACTCTATTCC 
                   
               
               
                   
                 GAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTAC 
                   
               
               
                   
                 TGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGA 
                   
               
               
                   
                 AGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCT 
                   
               
               
                   
                 TCTAGAATGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGGCGC 
                   
               
               
                   
                 TCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGG 
                   
               
               
                   
                 ACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAGATCTTCGACA 
                   
               
               
                   
                 TGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGA 
                   
               
               
                   
                 GGAGTTTGTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACA 
                   
               
               
                   
                 CATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATCCA 
                   
               
               
                   
                 CCGAGTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAG 
                   
               
               
                   
                 GCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCCCAGCTCCTC 
                   
               
               
                   
                 CTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATC 
                   
               
               
                   
                 TGTACAGCATGAAGTGCAAGAACGTGGTGCCCCTCTATGACCTGCTGCT 
                   
               
               
                   
                 GGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGG 
                   
               
               
                   
                 GGCATCCGTGGAGGAGACGGACCAAAGCCACTTGGCCACTGCGGGCTC 
                   
               
               
                   
                 TACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAGGCAGAG 
                   
               
               
                   
                 GGTTTCCCTGCCACGGTCTGAGAGCTCCCTGGCTCCCACACGGTTCAGA 
                   
               
               
                   
                 TAATCCCTGCTGCATTTTACCCTCATCATGCACCACTTTAGCCAAATTCT 
                   
               
               
                   
                 GTCTCCTGCATACACTCCGGCATGCATCCAACACCAATGGCTTTCTAGA 
                   
               
               
                   
                 TGAGTGGCCATTCATTTGCTTGCTCAGTTCTTAGTGGCACATCTTCTGTC 
                   
               
               
                   
                 TTCTGTTGGGAACAGCCAAAGGGATTCCAAGGCTAAATCTTTGTAACAG 
                   
               
               
                   
                 CTCTCTTTCCCCCTTGCTATGTTACTAAGCGTGAGGATTCCCGTAGCTCT 
                   
               
               
                   
                 TCACAGCTGAACTCAGTCTATGGGTTGGGGCTCAGATAACTCTGTGCAT 
                   
               
               
                   
                 TTAAGCTACTTGTAGAGACCCAGGCCTGGAGAGTAGACATTTTGCCTCT 
                   
               
               
                   
                 GATAAGCACTTTTTAAATGGCTCTAAGAATAAGCCACAGCAAAGAATTT 
                   
               
               
                   
                 AAAGTGGCTCCTTTAATTGGTGACTTGGAGAAAGCTAGGTCAAGGGTTT 
                   
               
               
                   
                 ATTATAGCACCCTCTTGTATTCCTATGGCAATGCATCCTTTTATGAAAGT 
                   
               
               
                   
                 GGTACACCTTAAAGCTTTTATATGACTGTAGCAGAGTATCTGGTGATTG 
                   
               
               
                   
                 TCAATTCATTCCCCCTATAGGAATACAAGGGGCACACAGGGAAGGCAG 
                   
               
               
                   
                 ATCCCCTAGTTGGCAAGACTATTTTAACTTGATACACTGCAGATTCAGA 
                   
               
               
                   
                 TGTGCTGAAAGCTCTGCCTCTGGCTTTCCGGTCATGGGTTCCAGTTAATT 
                   
               
               
                   
                 CATGCCTCCCATGGACCTATGGAGAGCAGCAAGTTGATCTTAGTTAAGT 
                   
               
               
                   
                 CTCCCTATATGAGGGATAAGTTCCTGATTTTTGTTTTTATTTTTGTGTTAC 
                   
               
               
                   
                 AAAAGAAAGCCCTCCCTCCCTGAACTTGCAGTAAGGTCAGCTTCAGGAC 
                   
               
               
                   
                 CTGTTCCAGTGGGCACTGTACTTGGATCTTCCCGGCGTGTGTGTGCCTTA 
                   
               
               
                   
                 CACAGGGGTGAACTGTTCACTGTGGTGATGCATGATGAGGGTAAATGG 
                   
               
               
                   
                 TAGTTGAAAGGAGCAGGGGCCCTGGTGTTGCATTTAGCCCTGGGGCATG 
                   
               
               
                   
                 GAGCTGAACAGTACTTGTGCAGGATTGTTGTGGCTACTAGAGAACAAG 
                   
               
               
                   
                 AGGGAAAGTAGGGCAGAAACTGGATACAGTTCTGAGGCACAGCCAGAC 
                   
               
               
                   
                 TTGCTCAGGGTGGCCCTGCCACAGGCTGCAGCTACCTAGGAACATTCCT 
                   
               
               
                   
                 TGCAGACCCCGCATTGCCCTTTGGGGGTGCCCTGGGATCCCTGGGGTAG 
                   
               
               
                   
                 TCCAGCTCTTCTTCATTTCCCAGCGTGGCCCTGGTTGGAAGAAGCAGCT 
                   
               
               
                   
                 GTCACAGCTGCTGTAGACAGCTGTGTTCCTACAATTGGCCCAGCACCCT 
                   
               
               
                   
                 GGGGCACGGGAGAAGGGTGGGGACCGTTGCTGTCACTACTCAGGCTGA 
                   
               
               
                   
                 CTGGGGCCTGGTCAGATTACGTATGCCCTTGGTGGTTTAGAGATAATCC 
                   
               
               
                   
                 AAAATCAGGGTTTGGTTTGGGGAAGAAAATCCTCCCCCTTCCTCCCCCG 
                   
               
               
                   
                 CCCCGTTCCCTACCGCCTCCACTCCTGCCAGCTCATTTCCTTCAATTTCC 
                   
               
               
                   
                 TTTGACCTATAGGCTAAAAAAGAAAGGCTCATTCCAGCCACAGGGCAG 
                   
               
               
                   
                 CCTTCCCTGGGCCTTTGCTTCTCTAGCACAATTATGGGTTACTTCCTTTTT 
                   
               
               
                   
                 CTTAACAAAAAAGAATGTTTGATTTCCTCTGGGTGACCTTATTGTCTGTA 
                   
               
               
                   
                 ATTGAAACCCTATTGAGAGGTGATGTCTGTGTTAGCCAATGACCCAGGT 
                   
               
               
                   
                 GAGCTGCTCGGGCTTCTCTTGGTATGTCTTGTTTGGAAAAGTGGATTTCA 
                   
               
               
                   
                 TTCATTTCTGATTGTCCAGTTAAGTGATCACCAAAGGACTGAGAATCTG 
                   
               
               
                   
                 GGAGGGCAAAAAAAAAAAAAAAGTTTTTATGTGCACTTAAATTTGGGG 
                   
               
               
                   
                 ACAATTTTATGTATCTGTGTTAAGGATATGTTTAAGAACATAATTCTTTT 
                   
               
               
                   
                 GTTGCTGTTTGTTTAAGAAGCACCTTAGTTTGTTTAAGAAGCACCTTATA 
                   
               
               
                   
                 TAGTATAATATATATTTTTTTGAAATTACATTGCTTGTTTATCAGACAAT 
                   
               
               
                   
                 TGAATGTAGTAATTCTGTTCTGGATTTAATTTGACTGGGTTAACATGCA 
                   
               
               
                   
                 AAAACCAAGGAAAAATATTTAGTTTTTTTTTTTTTTTTTGTATACTTTTC 
                   
               
               
                   
                 AAGCTACCTTGTCATGTATACAGTCATTTATGCCTAAAGCCTGGTGATT 
                   
               
               
                   
                 ATTCATTTAAATGAAGATCACATTTCATATCAACTTTTGTATCCACAGTA 
                   
               
               
                   
                 GACAAAATAGCACTAATCCAGATGCCTATTGTTGGATACTGAATGACAG 
                   
               
               
                   
                 ACAATCTTATGTAGCAAAGATTATGCCTGAAAAGGAAAATTATTCAGG 
                   
               
               
                   
                 GCAGCTAATTTTGCTTTTACCAAAATATCAGTAGTAATATTTTTGGACA 
                   
               
               
                   
                 GTAGCTAATGGGTCAGTGGGTTCTTTTTAATGTTTATACTTAGATTTTCT 
                   
               
               
                   
                 TTTAAAAAAATTAAAATAAAACAAAAAAAAATTTCTAGGACTAGACGA 
                   
               
               
                   
                 TGTAATACCAGCTAAAGCCAAACAATTATACAGTGGAAGGTTTTACATT 
                   
               
               
                   
                 ATTCATCCAATGTGTTTCTATTCATGTTAAGATACTACTACATTTGAAGT 
                   
               
               
                   
                 GGGCAGAGAACATCAGATGATTGAAATGTTCGCCCAGGGGTCTCCAGC 
                   
               
               
                   
                 AACTTTGGAAATCTCTTTGTATTTTTACTTGAAGTGCCACTAATGGACAG 
                   
               
               
                   
                 CAGATATTTTCTGGCTGATGTTGGTATTGGGTGTAGGAACATGATTTAA 
                   
               
               
                   
                 AAAAAAACTCTTGCCTCTGCTTTCCCCCACTCTGAGGCAAGTTAAAATG 
                   
               
               
                   
                 TAAAAGATGTGATTTATCTGGGGGGCTCAGGTATGGTGGGGAAGTGGA 
                   
               
               
                   
                 TTCAGGAATCTGGGGAATGGCAAATATATTAAGAAGAGTATTGAAAGT 
                   
               
               
                   
                 ATTTGGAGGAAAATGGTTAATTCTGGGTGTGCACCAGGGTTCAGTAGAG 
                   
               
               
                   
                 TCCACTTCTGCCCTGGAGACCACAAATCAACTAGCTCCATTTACAGCCA 
                   
               
               
                   
                 TTTCTAAAATGGCAGCTTCAGTTCTAGAGAAGAAAGAACAACATCAGC 
                   
               
               
                   
                 AGTAAAGTCCATGGAATAGCTAGTGGTCTGTGTTTCTTTTCGCCATTGCC 
                   
               
               
                   
                 TAGCTTGCCGTAATGATTCTATAATGCCATCATGCAGCAATTATGAGAG 
                   
               
               
                   
                 GCTAGGTCATCCAAAGAGAAGACCCTATCAATGTAGGTTGCAAAATCT 
                   
               
               
                   
                 AACCCCTAAGGAAGTGCAGTCTTTGATTTGATTTCCCTAGTAACCTTGC 
                   
               
               
                   
                 AGATATGTTTAACCAAGCCATAGCCCATGCCTTTTGAGGGCTGAACAAA 
                   
               
               
                   
                 TAAGGGACTTACTGATAATTTACTTTTGATCACATTAAGGTGTTCTCACC 
                   
               
               
                   
                 TTGAAATCTTATACACTGAAATGGCCATTGATTTAGGCCACTGGCTTAG 
                   
               
               
                   
                 AGTACTCCTTCCCCTGCATGACACTGATTACAAATACTTTCCTATTCATA 
                   
               
               
                   
                 CTTTCCAATTATGAGATGGACTGTGGGTACTGGGAGTGATCACTAACAC 
                   
               
               
                   
                 CATAGTAATGTCTAATATTCACAGGCAGATCTGCTTGGGGAAGCTAGTT 
                   
               
               
                   
                 ATGTGAAAGGCAAATAGAGTCATACAGTAGCTCAAAAGGCAACCATAA 
                   
               
               
                   
                 TTCTCTTTGGTGCAGGTCTTGGGAGCGTGATCTAGATTACACTGCACCA 
                   
               
               
                   
                 TTCCCAAGTTAATCCCCTGAAAACTTACTCTCAACTGGAGCAAATGAAC 
                   
               
               
                   
                 TTTGGTCCCAAATATCCATCTTTTCAGTAGCGTTAATTATGCTCTGTTTC 
                   
               
               
                   
                 CAACTGCATTTCCTTTCCAATTGAATTAAAGTGTGGCCTCGTTTTTAGTC 
                   
               
               
                   
                 ATTTAAAATTGTTTTCTAAGTAATTGCTGCCTCTATTATGGCACTTCAAT 
                   
               
               
                   
                 TTTGCACTGTCTTTTGAGATTCAAGAAAAATTTCTATTCTTTTTTTTGCAT 
                   
               
               
                   
                 CCAATTGTGCCTGAACTTTTAAAATATGTAAATGCTGCCATGTTCCAAA 
                   
               
               
                   
                 CCCATCGTCAGTGTGTGTGTTTAGAGCTGTGCACCCTAGAAACAACATA 
                   
               
               
                   
                 TTGTCCCATGAGCAGGTGCCTGAGACACAGACCCCTTTGCATTCACAGA 
                   
               
               
                   
                 GAGGTCATTGGTTATAGAGACTTGAATTAATAAGTGACATTATGCCAGT 
                   
               
               
                   
                 TTCTGTTCTCTCACAGGTGATAAACAATGCTTTTTGTGCACTACATACTC 
                   
               
               
                   
                 TTCAGTGTAGAGCTCTTGTTTTATGGGAAAAGGCTCAAATGCCAAATTG 
                   
               
               
                   
                 TGTTTGATGGATTAATATGCCCTTTTGCCGATGCATACTATTACTGATGT 
                   
               
               
                   
                 GACTCGGTTTTGTCGCAGCTTTGCTTTGTTTAATGAAACACACTTGTAAA 
                   
               
               
                   
                 CCTCTTTTGCACTTTGAAAAAGAATCCAGCGGGATGCTCGAGCACCTGT 
                   
               
               
                   
                 AAACAATTTTCTCAACCTATTTGATGTTCAAATAAAGAATTAAACTAAA 
                   
               
               
                   
               
               
                 NM_130398 
                 AAATTGAAAGGTCAGCCTTTCGCGCGCTGTGTAGGCAAGTTACCCGTGT 
                 166 
               
               
                   
                 TCTGCGTTGCCGGCCGTGGGTGCTCTGGCCACAGTGAGTTAGGGGCGTC 
                   
               
               
                   
                 GGAGCGGGTTTCTCCAACCGCAATCGGCTCCGCTCAAGGGGAGGAGGA 
                   
               
               
                   
                 GAGTCCCTTCTCGGAAGGCCTAAGGAAACGTGTCGTCTGGAATGGGCTT 
                   
               
               
                   
                 GGGGGCCACGCCTGCACATCTCCGCGAGACAGAGGGATAAAGTGAAGA 
                   
               
               
                   
                 TGGTGCTGTTATTGTTACCTCGAGTGCCACATGCGACCTCTGAGATATG 
                   
               
               
                   
                 TACACAGTCATTCTTACTATCGCACTCAGCCATTCTTACTACGCTAAAG 
                   
               
               
                   
                 AAGAAATAATTATTCGAGGATATTTGCCTGGCCCAGAAGAAACTTATGT 
                   
               
               
                   
                 AAATTTCATGAACTATTATATCCGTTTTCCTCGGAGTGAGAGAAAACTC 
                   
               
               
                   
                 TTTTTAGATATCATCTGAGAGAACTAGTGAATCCCAGTCACTGAGTGGA 
                   
               
               
                   
                 GTTGAGAGTCTAAGAACCTCTGAAATTTGAGAACTGCTGGACCAGAGC 
                   
               
               
                   
                 CTTTAGAGCTCTGATAAGGTGTCAACAGGGTAGTTAATTTGGCACCATG 
                   
               
               
                   
                 GGGATACAGGGATTGCTACAATTTATCAAAGAAGCTTCAGAACCCATCC 
                   
               
               
                   
                 ATGTGAGGAAGTATAAAGGGCAGGTAGTAGCTGTGGATACATATTGCT 
                   
               
               
                   
                 GGCTTCACAAAGGAGCTATTGCTTGTGCTGAAAAACTAGCCAAAGGTG 
                   
               
               
                   
                 AACCTACTGATAGGTATGTAGGATTTTGTATGAAATTTGTAAATATGTT 
                   
               
               
                   
                 ACTATCTCATGGGATCAAGCCTATTCTCGTATTTGATGGATGTACTTTAC 
                   
               
               
                   
                 CTTCTAAAAAGGAAGTAGAGAGATCTAGAAGAGAAAGACGACAAGCC 
                   
               
               
                   
                 AATCTTCTTAAGGGAAAGCAACTTCTTCGTGAGGGGAAAGTCTCGGAA 
                   
               
               
                   
                 GCTCGAGAGTGTTTCACCCGGTCTATCAATATCACACATGCCATGGCCC 
                   
               
               
                   
                 ACAAAGTAATTAAAGCTGCCCGGTCTCAGGGGGTAGATTGCCTCGTGGC 
                   
               
               
                   
                 TCCCTATGAAGCTGATGCGCAGTTGGCCTATCTTAACAAAGCGGGAATT 
                   
               
               
                   
                 GTGCAAGCCATAATTACAGAGGACTCGGATCTCCTAGCTTTTGGCTGTA 
                   
               
               
                   
                 AAAAGGTAATTTTAAAGATGGACCAGTTTGGAAATGGACTTGAAATTG 
                   
               
               
                   
                 ATCAAGCTCGGCTAGGAATGTGCAGACAGCTTGGGGATGTATTCACGG 
                   
               
               
                   
                 AAGAGAAGTTTCGTTACATGTGTATTCTTTCAGGTTGTGACTACCTGTCA 
                   
               
               
                   
                 TCACTGCGTGGGATTGGATTAGCAAAGGCATGCAAAGTCCTAAGACTA 
                   
               
               
                   
                 GCCAATAATCCAGATATAGTAAAGGTTATCAAGAAAATTGGACATTATC 
                   
               
               
                   
                 TCAAGATGAATATCACGGTACCAGAGGATTACATCAACGGGTTTATTCG 
                   
               
               
                   
                 GGCCAACAATACCTTCCTCTATCAGCTAGTTTTTGATCCCATCAAAAGG 
                   
               
               
                   
                 AAACTTATTCCTCTGAACGCCTATGAAGATGATGTTGATCCTGAAACAC 
                   
               
               
                   
                 TAAGCTACGCTGGGCAATATGTTGATGATTCCATAGCTCTTCAAATAGC 
                   
               
               
                   
                 ACTTGGAAATAAAGATATAAATACTTTTGAACAGATCGATGACTACAAT 
                   
               
               
                   
                 CCAGACACTGCTATGCCTGCCCATTCAAGAAGTCATAGTTGGGATGACA 
                   
               
               
                   
                 AAACATGTCAAAAGTCAGCTAATGTTAGCAGCATTTGGCATAGGAATTA 
                   
               
               
                   
                 CTCTCCCAGACCAGAGTCGGGTACTGTTTCAGATGCCCCACAATTGAAG 
                   
               
               
                   
                 GAAAATCCAAGTACTGTGGGAGTGGAACGAGTGATTAGTACTAAAGGG 
                   
               
               
                   
                 TTAAATCTCCCAAGGAAATCATCCATTGTGAAAAGACCAAGAAGTGCA 
                   
               
               
                   
                 GAGCTGTCAGAAGATGACCTGTTGAGTCAGTATTCTCTTTCATTTACGA 
                   
               
               
                   
                 AGAAGACCAAGAAAAATAGCTCTGAAGGCAATAAATCATTGAGCTTTT 
                   
               
               
                   
                 CTGAAGTGTTTGTGCCTGACCTGGTAAATGGACCTACTAACAAAAAGAG 
                   
               
               
                   
                 TGTAAGCACTCCACCTAGGACGAGAAATAAATTTGCAACATTTTTACAA 
                   
               
               
                   
                 AGGAAAAATGAAGAAAGTGGTGCAGTTGTGGTTCCAGGGACCAGAAGC 
                   
               
               
                   
                 AGGTTTTTTTGCAGTTCAGATTCTACTGACTGTGTATCAAACAAAGTGA 
                   
               
               
                   
                 GCATCCAGCCTCTGGATGAAACTGCTGTCACAGATAAAGAGAACAATC 
                   
               
               
                   
                 TGCATGAATCAGAGTATGGAGACCAAGAAGGCAAGAGACTGGTTGACA 
                   
               
               
                   
                 CAGATGTAGCACGTAATTCAAGTGATGACATTCCGAATAATCATATTCC 
                   
               
               
                   
                 AGGTGATCATATTCCAGACAAGGCAACAGTGTTTACAGATGAAGAGTC 
                   
               
               
                   
                 CTACTCTTTTGAGAGCAGCAAATTTACAAGGACCATTTCACCACCCACT 
                   
               
               
                   
                 TTGGGAACACTAAGAAGTTGTTTTAGTTGGTCTGGAGGTCTTGGAGATT 
                   
               
               
                   
                 TTTCAAGAACGCCGAGCCCCTCTCCAAGCACAGCATTGCAGCAGTTCCG 
                   
               
               
                   
                 AAGAAAGAGCGATTCCCCCACCTCTTTGCCTGAGAATAATATGTCTGAT 
                   
               
               
                   
                 GTGTCGCAGTTAAAGAGCGAGGAGTCCAGTGACGATGAGTCTCATCCCT 
                   
               
               
                   
                 TACGAGAAGAGGCATGTTCTTCACAGTCCCAGGAAAGTGGAGAATTCT 
                   
               
               
                   
                 CACTGCAGAGTTCAAATGCATCAAAGCTTTCTCAGTGCTCTAGTAAGGA 
                   
               
               
                   
                 CTCTGATTCAGAGGAATCTGATTGCAATATTAAGTTACTTGACAGTCAA 
                   
               
               
                   
                 AGTGACCAGACCTCCAAGCTACGTTTATCTCATTTCTCAAAAAAAGACA 
                   
               
               
                   
                 CACCTCTAAGGAACAAGGTTCCTGGGCTATATAAGTCCAGTTCTGCAGA 
                   
               
               
                   
                 CTCTCTTTCTACAACCAAGATCAAACCTCTAGGACCTGCCAGAGCCAGT 
                   
               
               
                   
                 GGGCTGAGCAAGAAGCCGGCAAGCATCCAGAAGAGAAAGCATCATAAT 
                   
               
               
                   
                 GCCGAGAACAAGCCGGGGTTACAGATCAAACTCAATGAGCTCTGGAAA 
                   
               
               
                   
                 AACTTTGGATTTAAAAAAGATTCTGAAAAGCTTCCTCCTTGTAAGAAAC 
                   
               
               
                   
                 CCCTGTCCCCAGTCAGAGATAACATCCAACTAACTCCAGAAGCGGAAG 
                   
               
               
                   
                 AGGATATATTTAACAAACCTGAATGTGGCCGTGTTCAAAGAGCAATATT 
                   
               
               
                   
                 CCAGTAAATGCAGACTGCTGCAAAGCTTTTGCCTGCAAGAGAATCTGAT 
                   
               
               
                   
                 CAATTTGAAGTCCCTGTTTGGGAATGAGGCACTTATCAGCATGAAGAAT 
                   
               
               
                   
                 TTTTTCTCATTCTGTGCCATTTTAAAAATAGAATACATTTTGTATATTAA 
                   
               
               
                   
                 CTTTATAATTGGGTTGTGGTTTTTTTGCTCAGCTTTTTATATTTTTATAAG 
                   
               
               
                   
                 AAGCTAAATAGAAGAATAATTGTATCTCTGACAGGTTTTTGGAGGTTTT 
                   
               
               
                   
                 AGTGTTAATTGGGAAAATCCTCTGGAGTTTATAAAAGTCTACTCTAAAT 
                   
               
               
                   
                 ATTTCTGTAATGTTGTCAAGTAGAAAGATAGTAAATGGAGAAACTACA 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 AB209631 
                 CCATGACCTGCCTTGAGAAGGGGCAGGGGAAGCCAGATGGACTGGAAG 
                 167 
               
               
                   
                 TGGAGTGGCAGTGACCAAGGAGGAGGAGGTGTGATAGGCTTCCCACGC 
                   
               
               
                   
                 AGGGTAGATCCAGAGACACCAGTGCCACCCATAGGCCCCTAGGACTGC 
                   
               
               
                   
                 AGTGGTCACCCGATTCCTTTGTCCCAGCTGAGACTCAGTTCTGAGTGTTC 
                   
               
               
                   
                 TATTTTGGGGAACAGAGGCGTCCTTGGTAGCATTTGGAAGAGGATAGCC 
                   
               
               
                   
                 AGCTGGGGTGTGTGTACATCACAGCCTGACAGTAACAGCATCCGAACC 
                   
               
               
                   
                 AGAGGTGACTGGCTAAGGGCAGACCCAGGGCAACAGGTTAACCGTTCT 
                   
               
               
                   
                 AGGGCCGGGCACAGGGAGGAGAACATTCCAACACTCTGTGTGCCCAGT 
                   
               
               
                   
                 GCCGACGCACGTTCTCTCTTTTATCCTCAAAACAGTCCTATGAGGATAT 
                   
               
               
                   
                 AAGCCAGAGAGAGACAGAGACAAGGAATTACAAGTTGGTGAGAGTCA 
                   
               
               
                   
                 GGATTTGAACTTGGCTCTGGCAGATGGAAAATTAGGGTCTGTATTCTTT 
                   
               
               
                   
                 ACAAAACCGTGTGTGCCTCAGATGGAGTTGGTGCATAACAAGCAGAGG 
                   
               
               
                   
                 TATCCAGGGTCGCGGTCCTGCTTGCCACGGAAGGGGCCGCCTTGTCAGT 
                   
               
               
                   
                 TGTGACCACCCAGCCCTGGAAATGTCAGTAATGCTGTAAGGAGTGGGG 
                   
               
               
                   
                 ATCGGATCAGATGCCATCCAGATGCTGAAGTTTGACCTTGTGTCATTTTT 
                   
               
               
                   
                 CACTTTCTTTTTTGGCTCTTCTGCAATCAATTCATTTATTTAGCAAAAAA 
                   
               
               
                   
                 GAAATTATGTGTGCCGAGAGCATGCAGAAGATATGTCTCCGTTCTCTGC 
                   
               
               
                   
                 TTCCCTCCAAAAAAGAATCCCAAAACTGCTTTCTGTGAACGTGTGCCAG 
                   
               
               
                   
                 GGTCCCAGCAGGACTCAGGGAGAGCAGGAAGCCCAGCCCAGACCCCTT 
                   
               
               
                   
                 GCACAACCTACCGTGGGGAGGCCTTAGGCTCTGGCTACTACAGAGCTG 
                   
               
               
                   
                 GTTCCAGTCTGCACTGCCACAGCCTGGCCAGGGACTTGGACACATCTGC 
                   
               
               
                   
                 TGGCCACTTCCTGTCTCAGTTTCCTTATCTGCAAAATAAGGGAAAAGCC 
                   
               
               
                   
                 CCCACAAAGGTGCACGTGTAGCAGGAGCTCTTTTCCCTCCCTATTTTAG 
                   
               
               
                   
                 GAAGGCAGTTGGTGGGAAGTCCAGCTTGGGTCCCTGAGAGCTGTGAGA 
                   
               
               
                   
                 AGGAGATGCGGCTGCTGCTGGCCCTGTTGGGGGTCCTGCTGAGTGTGCC 
                   
               
               
                   
                 TGGGCCTCCAGTCTTGTCCCTGGAGGCCTCTGAGGAAGTGGAGCTTGGT 
                   
               
               
                   
                 ATGGCTTCTGAGGTGGGAGAGGGTGGCAGGGGTGGGAAGAGTGGGCAC 
                   
               
               
                   
                 CAGGAGGGGGCTGCTGGGCTGAGCAAAGCTGGAAAGGATCCTTGCCCA 
                   
               
               
                   
                 GGCCCTGAGAAGGTGGCGGCAGGGCAGGGCTCAACCACTGAGACTCAG 
                   
               
               
                   
                 TCAGTGCCTGGCTTCCAGCAAGCATTCATCTATCACTGTGTCTGCGAGA 
                   
               
               
                   
                 GAGGACTGGCCTTGCAGGGCGCAGGGCCCTAAGCTGGGCTGCAGAGCT 
                   
               
               
                   
                 GGTGGTGAGCTCCTTGCCTGGGTGTGTGTGCGTGTGTGTGTGTGTTCTGT 
                   
               
               
                   
                 GCACTGGGTGTGTGACCTAGGAGGTCCAGGCAGCATGTGTGGTATAAG 
                   
               
               
                   
                 CATTATGAGGGTGATATGCCCCGGTGCAGCATGACCCTGTATGTGGCAC 
                   
               
               
                   
                 CAACAGCATGTGCCTTGTGTGTGTGTGTGTCCGTATGTGTGTGTGTGTAT 
                   
               
               
                   
                 GCGTGTGTGTGTGTGTGTGTGTGTGTCTTGGCCACTGTCATGTGCACTAA 
                   
               
               
                   
                 ATGCTGTGTGTGTGACATGCCCCAAGAGTGTGGCATTTGCCCTGGGTGT 
                   
               
               
                   
                 GGCATCCGCAGCATGTGGCTGTGTGGGTGTCAAGGAGTGGTGGCTCCTT 
                   
               
               
                   
                 CAGCATGCGTTGCGAAGTGCTTGTGCCCTGCATGTGCGGTGTGTTCTCT 
                   
               
               
                   
                 GTACACAGGAGGCTGCCTCAGATGGGGCTGCGGGGTCTGCTGACCTCTG 
                   
               
               
                   
                 CCCTCTGCCCACAGAGCCCTGCCTGGCTCCCAGCCTGGAGCAGCAAGAG 
                   
               
               
                   
                 CAGGAGCTGACAGTAGCCCTTGGGCAGCCTGTGCGGCTGTGCTGTGGGC 
                   
               
               
                   
                 GGGCTGAGCGTGGTGGCCACTGGTACAAGGAGGGCAGTCGCCTGGCAC 
                   
               
               
                   
                 CTGCTGGCCGTGTACGGGGCTGGAGGGGCCGCCTAGAGATTGCCAGCTT 
                   
               
               
                   
                 CCTACCTGAGGATGCTGGCCGCTACCTCTGCCTGGCACGAGGCTCCATG 
                   
               
               
                   
                 ATCGTCCTGCAGAATCTCACCTTGATTACAGGTGACTCCTTGACCTCCA 
                   
               
               
                   
                 GCAACGATGATGAGGACCCCAAGTCCCATAGGGACCTCTCGAATAGGC 
                   
               
               
                   
                 ACAGTTACCCCCAGCAAGGTCAGTAGGTCTCCAAGGACTTGTGTCCCCG 
                   
               
               
                   
                 CTGCTGCTCATCTGATCACTGAGAAGAGGAGGCCTGTGTGGGAACACA 
                   
               
               
                   
                 CGGTCATTCTAGGGGCCTTCCCCTGCCCTCCAGCACCCTACTGGACACA 
                   
               
               
                   
                 CCCCCAGCGCATGGAGAAGAAACTGCATGCAGTACCTGCGGGGAACAC 
                   
               
               
                   
                 CGTCAAGTTCCGCTGTCCAGCTGCAGGCAACCCCACGCCCACCATCCGC 
                   
               
               
                   
                 TGGCTTAAGGATGGACAGGCCTTTCATGGGGAGAACCGCATTGGAGGC 
                   
               
               
                   
                 ATTCGGCTGCGCCATCAGCACTGGAGTCTCGTGATGGAGAGCGTGGTGC 
                   
               
               
                   
                 CCTCGGACCGCGGCACATACACCTGCCTGGTAGAGAACGCTGTGGGCA 
                   
               
               
                   
                 GCATCCGTTATAACTACCTGCTAGATGTGCTGGAGCGGTCCCCGCACCG 
                   
               
               
                   
                 GCCCATCCTGCAGGCCGGGCTCCCGGCCAACACCACAGCCGTGGTGGG 
                   
               
               
                   
                 CAGCGACGTGGAGCTGCTGTGCAAGGTGTACAGCGATGCCCAGCCCCA 
                   
               
               
                   
                 CATCCAGTGGCTGAAGCACATCGTCATCAACGGCAGCAGCTTCGGAGC 
                   
               
               
                   
                 CGACGGTTTCCCCTATGTGCAAGTCCTAAAGACTGCAGACATCAATAGC 
                   
               
               
                   
                 TCAGAGGTGGAGGTCCTGTACCTGCGGAACGTGTCAGCCGAGGACGCA 
                   
               
               
                   
                 GGCGAGTACACCTGCCTCGCAGGCAATTCCATCGGCCTCTCCTACCAGT 
                   
               
               
                   
                 CTGCCTGGCTCACGGTGCTGCCAGGTGAGCACCTGAAGGGCCAGGAGA 
                   
               
               
                   
                 TGCTGCGAGATGCCCCTCTGGGCCAGCAGTGGGGGCTGTGGCCTGTTGG 
                   
               
               
                   
                 GTGGTCAGTCTCTGTTGGCCTGTGGGGTCTGGCCTGGGGGGCAGTGTGT 
                   
               
               
                   
                 GGATTTGTGGGTTTGAGCTGTATGACAGCCCCTCTGTGCCTCTCCACAC 
                   
               
               
                   
                 GTGGCCGTCCATGTGACCGTCTGCTGAGGTGTGGGTGCCTGGGACTGGG 
                   
               
               
                   
                 CATAACTACAGCTTCCTCCGTGTGTGTCCCCACATATGTTGGGAGCTGG 
                   
               
               
                   
                 GAGGGACTGAGTTAGGGTGCACGGGGCGGCCAGTCTCACCACTGACCA 
                   
               
               
                   
                 GTTTGTCTGTCTGTGTGTGTCCATGTGCGAGGGCAGAGGAGGACCCCAC 
                   
               
               
                   
                 ATGGACCGCAGCAGCGCCCGAGGCCAGGTATACGGACATCATCCTGTA 
                   
               
               
                   
                 CGCGTCGGGCTCCCTGGCCTTGGCTGTGCTCCTGCTGCTGGCCAGGCTG 
                   
               
               
                   
                 TATCGAGGGCAGGCGCTCCACGGCCGGCACCCCCGCCCGCCCGCCACT 
                   
               
               
                   
                 GTGCAGAAGCTCTCCCGCTTCCCTCTGGCCCGACAGTTCTCCCTGGAGT 
                   
               
               
                   
                 CAGGCTCTTCCGGCAAGTCAAGCTCATCCCTGGTACGAGGCGTGCGTCT 
                   
               
               
                   
                 CTCCTCCAGCGGCCCCGCCTTGCTCGCCGGCCTCGTGAGTCTAGATCTA 
                   
               
               
                   
                 CCTCTCGACCCACTATGGGAGTTCCCCCGGGACAGGCTGGTGCTTGGGA 
                   
               
               
                   
                 AGCCCCTAGGCGAGGGCTGCTTTGGCCAGGTAGTACGTGCAGAGGCCTT 
                   
               
               
                   
                 TGGCATGGACCCTGCCCGGCCTGACCAAGCCAGCACTGTGGCCGTCAA 
                   
               
               
                   
                 GATGCTCAAAGACAACGCCTCTGACAAGGACCTGGCCGACCTGGTCTC 
                   
               
               
                   
                 GGAGATGGAGGTGATGAAGCTGATCGGCCGACACAAGAACATCATCAA 
                   
               
               
                   
                 CCTGCTTGGTGTCTGCACCCAGGAAGGGCCCCTGTACGTGATCGTGGAG 
                   
               
               
                   
                 TGCGCCGCCAAGGGAAACCTGCGGGAGTTCCTGCGGGCCCGGCGCCCC 
                   
               
               
                   
                 CCAGGCCCCGACCTCAGCCCCGACGGTCCTCGGAGCAGTGAGGGGCCG 
                   
               
               
                   
                 CTCTCCTTCCCAGTCCTGGTCTCCTGCGCCTACCAGGTGGCCCGAGGCA 
                   
               
               
                   
                 TGCAGTATCTGGAGTCCCGGAAGTGTATCCACCGGGACCTGGCTGCCCG 
                   
               
               
                   
                 CAATGTGCTGGTGACTGAGGACAATGTGATGAAGATTGCTGACTTTGGG 
                   
               
               
                   
                 CTGGCCCGCGGCGTCCACCACATTGACTACTATAAGAAAACCAGCAAC 
                   
               
               
                   
                 GGCCGCCTGCCTGTGAAGTGGATGGCGCCCGAGGCCTTGTTTGACCGGG 
                   
               
               
                   
                 TGTACACACACCAGAGTGACGTGTGGTCTTTTGGGATCCTGCTATGGGA 
                   
               
               
                   
                 GATCTTCACCCTCGGGGGCTCCCCGTATCCTGGCATCCCGGTGGAGGAG 
                   
               
               
                   
                 CTGTTCTCGCTGCTGCGGGAGGGACATCGGATGGACCGACCCCCACACT 
                   
               
               
                   
                 GCCCCCCAGAGCTGTACGGGCTGATGCGTGAGTGCTGGCACGCAGCGC 
                   
               
               
                   
                 CCTCCCAGAGGCCTACCTTCAAGCAGCTGGTGGAGGCGCTGGACAAGG 
                   
               
               
                   
                 TCCTGCTGGCCGTCTCTGAGGAGTACCTCGACCTCCGCCTGACCTTCGG 
                   
               
               
                   
                 ACCCTATTCCCCCTCTGGTGGGGACGCCAGCAGCACCTGCTCCTCCAGC 
                   
               
               
                   
                 GATTCTGTCTTCAGCCACGACCCCCTGCCATTGGGATCCAGCTCCTTCCC 
                   
               
               
                   
                 CTTCGGGTCTGGGGTGCAGACATGAGCAAGGCTCAAGGCTGTGCAGGC 
                   
               
               
                   
                 ACATAGGCTGGTGGCCTTGGGCCTTGGGGCTCAGCCACAGCCTGACACA 
                   
               
               
                   
                 GTGCTCGACCTTGATAGCATGGGGCCCCTGGCCCAGAGTTGCTGTGCCG 
                   
               
               
                   
                 TGTCCAAGGGCCGTGCCCTTGCCCTTGGAGCTGCCGTGCCTGTGTCCTG 
                   
               
               
                   
                 ATGGCCCAAATGTCAGGGTTCTGCTCGGCTTCTTGGACCTTGGCGCTTA 
                   
               
               
                   
                 GTCCCCATCCCGGGTTTGGCTGAGCCTGGCTGGAGAGCTGCTATGCTAA 
                   
               
               
                   
                 ACCTCCTGCCTCCCAATACCAGCAGGAGGTTCTGGGCCTCTGAACCCCC 
                   
               
               
                   
                 TTTCCCCACACCTCCCCCTGCTGCTGCTGCCCCAGCGTCTTGACGGGAG 
                   
               
               
                   
                 CATTGGCCCCTGAGCCCAGAGAAGCTGGAAGCCTGCCGAAAACAGGAG 
                   
               
               
                   
                 CAAATGGCGTTTTATAAATTATTTTTTTGAAAT 
                   
               
               
                   
               
               
                 NM_004496 
                 TAAGATCCACATCAGCTCAACTGCACTTGCCTCGCAGAGGCAGCCCGCT 
                 168 
               
               
                   
                 CACTTCCCGCGGAGGCGCTCCCCGGCGCCGCGCTCCGCGGCAGCCGCCT 
                   
               
               
                   
                 GCCCCCGGCGCTGCCCCCGCCCGCCGCGCCGCCGCCGCCGCCGCGCACG 
                   
               
               
                   
                 CCGCGCCCCGCAGCTCTGGGCTTCCTCTTCGCCCGGGTGGCGTTGGGCC 
                   
               
               
                   
                 CGCGCGGGCGCTCGGGTGACTGCAGCTGCTCAGCTCCCCTCCCCCGCCC 
                   
               
               
                   
                 CGCGCCGCGCGGCCGCCCGTCGCTTCGCACAGGGCTGGATGGTTGTATT 
                   
               
               
                   
                 GGGCAGGGTGGCTCCAGGATGTTAGGAACTGTGAAGATGGAAGGGCAT 
                   
               
               
                   
                 GAAACCAGCGACTGGAACAGCTACTACGCAGACACGCAGGAGGCCTAC 
                   
               
               
                   
                 TCCTCCGTCCCGGTCAGCAACATGAACTCAGGCCTGGGCTCCATGAACT 
                   
               
               
                   
                 CCATGAACACCTACATGACCATGAACACCATGACTACGAGCGGCAACA 
                   
               
               
                   
                 TGACCCCGGCGTCCTTCAACATGTCCTATGCCAACCCGGGCCTAGGGGC 
                   
               
               
                   
                 CGGCCTGAGTCCCGGCGCAGTAGCCGGCATGCCGGGGGGCTCGGCGGG 
                   
               
               
                   
                 CGCCATGAACAGCATGACTGCGGCCGGCGTGACGGCCATGGGTACGGC 
                   
               
               
                   
                 GCTGAGCCCGAGCGGCATGGGCGCCATGGGTGCGCAGCAGGCGGCCTC 
                   
               
               
                   
                 CATGAATGGCCTGGGCCCCTACGCGGCCGCCATGAACCCGTGCATGAG 
                   
               
               
                   
                 CCCCATGGCGTACGCGCCGTCCAACCTGGGCCGCAGCCGCGCGGGCGG 
                   
               
               
                   
                 CGGCGGCGACGCCAAGACGTTCAAGCGCAGCTACCCGCACGCCAAGCC 
                   
               
               
                   
                 GCCCTACTCGTACATCTCGCTCATCACCATGGCCATCCAGCAGGCGCCC 
                   
               
               
                   
                 AGCAAGATGCTCACGCTGAGCGAGATCTACCAGTGGATCATGGACCTCT 
                   
               
               
                   
                 TCCCCTATTACCGGCAGAACCAGCAGCGCTGGCAGAACTCCATCCGCCA 
                   
               
               
                   
                 CTCGCTGTCCTTCAATGACTGCTTCGTCAAGGTGGCACGCTCCCCGGAC 
                   
               
               
                   
                 AAGCCGGGCAAGGGCTCCTACTGGACGCTGCACCCGGACTCCGGCAAC 
                   
               
               
                   
                 ATGTTCGAGAACGGCTGCTACTTGCGCCGCCAGAAGCGCTTCAAGTGCG 
                   
               
               
                   
                 AGAAGCAGCCGGGGGCCGGCGGCGGGGGCGGGAGCGGAAGCGGGGGC 
                   
               
               
                   
                 AGCGGCGCCAAGGGCGGCCCTGAGAGCCGCAAGGACCCCTCTGGCGCC 
                   
               
               
                   
                 TCTAACCCCAGCGCCGACTCGCCCCTCCATCGGGGTGTGCACGGGAAGA 
                   
               
               
                   
                 CCGGCCAGCTAGAGGGCGCGCCGGCCCCCGGGCCCGCCGCCAGCCCCC 
                   
               
               
                   
                 AGACTCTGGACCACAGTGGGGCGACGGCGACAGGGGGCGCCTCGGAGT 
                   
               
               
                   
                 TGAAGACTCCAGCCTCCTCAACTGCGCCCCCCATAAGCTCCGGGCCCGG 
                   
               
               
                   
                 GGCGCTGGCCTCTGTGCCCGCCTCTCACCCGGCACACGGCTTGGCACCC 
                   
               
               
                   
                 CACGAGTCCCAGCTGCACCTGAAAGGGGACCCCCACTACTCCTTCAACC 
                   
               
               
                   
                 ACCCGTTCTCCATCAACAACCTCATGTCCTCCTCGGAGCAGCAGCATAA 
                   
               
               
                   
                 GCTGGACTTCAAGGCATACGAACAGGCACTGCAATACTCGCCTTACGGC 
                   
               
               
                   
                 TCTACGTTGCCCGCCAGCCTGCCTCTAGGCAGCGCCTCGGTGACCACCA 
                   
               
               
                   
                 GGAGCCCCATCGAGCCCTCAGCCCTGGAGCCGGCGTACTACCAAGGTG 
                   
               
               
                   
                 TGTATTCCAGACCCGTCCTAAACACTTCCTAGCTCCCGGGACTGGGGGG 
                   
               
               
                   
                 TTTGTCTGGCATAGCCATGCTGGTAGCAAGAGAGAAAAAATCAACAGC 
                   
               
               
                   
                 AAACAAAACCACACAAACCAAACCGTCAACAGCATAATAAAATCCCAA 
                   
               
               
                   
                 CAACTATTTTTATTTCATTTTTCATGCACAACCTTTCCCCCAGTGCAAAA 
                   
               
               
                   
                 GACTGTTACTTTATTATTGTATTCAAAATTCATTGTGTATATTACTACAA 
                   
               
               
                   
                 AGACAACCCCAAACCAATTTTTTTCCTGCGAAGTTTAATGATCCACAAG 
                   
               
               
                   
                 TGTATATATGAAATTCTCCTCCTTCCTTGCCCCCCTCTCTTTCTTCCCTCT 
                   
               
               
                   
                 TTCCCCTCCAGACATTCTAGTTTGTGGAGGGTTATTTAAAAAAACAAAA 
                   
               
               
                   
                 AAGGAAGATGGTCAAGTTTGTAAAATATTTGTTTGTGCTTTTTCCCCCTC 
                   
               
               
                   
                 CTTACCTGACCCCCTACGAGTTTACAGGTCTGTGGCAATACTCTTAACC 
                   
               
               
                   
                 ATAAGAATTGAAATGGTGAAGAAACAAGTATACACTAGAGGCTCTTAA 
                   
               
               
                   
                 AAGTATTGAAAGACAATACTGCTGTTATATAGCAAGACATAAACAGAT 
                   
               
               
                   
                 TATAAACATCAGAGCCATTTGCTTCTCAGTTTACATTTCTGATACATGCA 
                   
               
               
                   
                 GATAGCAGATGTCTTTAAATGAAATACATGTATATTGTGTATGGACTTA 
                   
               
               
                   
                 ATTATGCACATGCTCAGATGTGTAGACATCCTCCGTATATTTACATAAC 
                   
               
               
                   
                 ATATAGAGGTAATAGATAGGTGATATACATGATACATTCTCAAGAGTTG 
                   
               
               
                   
                 CTTGACCGAAAGTTACAAGGACCCCAACCCCTTTGTCCTCTCTACCCAC 
                   
               
               
                   
                 AGATGGCCCTGGGAATCAATTCCTCAGGAATTGCCCTCAAGAACTCTGC 
                   
               
               
                   
                 TTCTTGCTTTGCAGAGTGCCATGGTCATGTCATTCTGAGGTCACATAAC 
                   
               
               
                   
                 ACATAAAATTAGTTTCTATGAGTGTATACCATTTAAAGAATTTTTTTTTC 
                   
               
               
                   
                 AGTAAAAGGGAATATTACAATGTTGGAGGAGAGATAAGTTATAGGGAG 
                   
               
               
                   
                 CTGGATTTCAAAACGTGGTCCAAGATTCAAAAATCCTATTGATAGTGGC 
                   
               
               
                   
                 CATTTTAATCATTGCCATCGTGTGCTTGTTTCATCCAGTGTTATGCACTT 
                   
               
               
                   
                 TCCACAGTTGGACATGGTGTTAGTATAGCCAGACGGGTTTCATTATTAT 
                   
               
               
                   
                 TTCTCTTTGCTTTCTCAATGTTAATTTATTGCATGGTTTATTCTTTTTCTTT 
                   
               
               
                   
                 ACAGCTGAAATTGCTTTAAATGATGGTTAAAATTACAAATTAAATTGTT 
                   
               
               
                   
                 AATTTTTATCAATGTGATTGTAATTAAAAATATTTTGATTTAAATAACAA 
                   
               
               
                   
                 AAATAATACCAGATTTTAAGCCGTGGAAAATGTTCTTGATCATTTGCAG 
                   
               
               
                   
                 TTAAGGACTTTAAATAAATCAAATGTTAACAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_001453 
                 ATGCAGGCGCGCTACTCCGTGTCCAGCCCCAACTCCCTGGGAGTGGTGC 
                 169 
               
               
                   
                 CCTACCTCGGCGGCGAGCAGAGCTACTACCGCGCGGCGGCCGCGGCGG 
                   
               
               
                   
                 CCGGGGGCGGCTACACCGCCATGCCGGCCCCCATGAGCGTGTACTCGC 
                   
               
               
                   
                 ACCCTGCGCACGCCGAGCAGTACCCGGGCGGCATGGCCCGCGCCTACG 
                   
               
               
                   
                 GGCCCTACACGCCGCAGCCGCAGCCCAAGGACATGGTGAAGCCGCCCT 
                   
               
               
                   
                 ATAGCTACATCGCGCTCATCACCATGGCCATCCAGAACGCCCCGGACAA 
                   
               
               
                   
                 GAAGATCACCCTGAACGGCATCTACCAGTTCATCATGGACCGCTTCCCC 
                   
               
               
                   
                 TTCTACCGGGACAACAAGCAGGGCTGGCAGAACAGCATCCGCCACAAC 
                   
               
               
                   
                 CTCTCGCTCAACGAGTGCTTCGTCAAGGTGCCGCGCGACGACAAGAAG 
                   
               
               
                   
                 CCGGGCAAGGGCAGCTACTGGACGCTGGACCCGGACTCCTACAACATG 
                   
               
               
                   
                 TTCGAGAACGGCAGCTTCCTGCGGCGGCGGCGGCGCTTCAAGAAGAAG 
                   
               
               
                   
                 GACGCGGTGAAGGACAAGGAGGAGAAGGACAGGCTGCACCTCAAGGA 
                   
               
               
                   
                 GCCGCCCCCGCCCGGCCGCCAGCCCCCGCCCGCGCCGCCGGAGCAGGC 
                   
               
               
                   
                 CGACGGCAACGCGCCCGGTCCGCAGCCGCCGCCCGTGCGCATCCAGGA 
                   
               
               
                   
                 CATCAAGACCGAGAACGGTACGTGCCCCTCGCCGCCCCAGCCCCTGTCC 
                   
               
               
                   
                 CCGGCCGCCGCCCTGGGCAGCGGCAGCGCCGCCGCGGTGCCCAAGATC 
                   
               
               
                   
                 GAGAGCCCCGACAGCAGCAGCAGCAGCCTGTCCAGCGGGAGCAGCCCC 
                   
               
               
                   
                 CCGGGCAGCCTGCCGTCGGCGCGGCCGCTCAGCCTGGACGGTGCGGAT 
                   
               
               
                   
                 TCCGCGCCGCCGCCGCCCGCGCCCTCCGCCCCGCCGCCGCACCATAGCC 
                   
               
               
                   
                 AGGGCTTCAGCGTGGACAACATCATGACGTCGCTGCGGGGGTCGCCGC 
                   
               
               
                   
                 AGAGCGCGGCCGCGGAGCTCAGCTCCGGCCTTCTGGCCTCGGCGGCCG 
                   
               
               
                   
                 CGTCCTCGCGCGCGGGGATCGCACCCCCGCTGGCGCTCGGCGCCTACTC 
                   
               
               
                   
                 GCCCGGCCAGAGCTCCCTCTACAGCTCCCCCTGCAGCCAGACCTCCAGC 
                   
               
               
                   
                 GCGGGCAGCTCGGGCGGCGGCGGCGGCGGCGCGGGGGCCGCGGGGGG 
                   
               
               
                   
                 CGCGGGCGGCGCCGGGACCTACCACTGCAACCTGCAAGCCATGAGCCT 
                   
               
               
                   
                 GTACGCGGCCGGCGAGCGCGGGGGCCACTTGCAGGGCGCGCCCGGGGG 
                   
               
               
                   
                 CGCGGGCGGCTCGGCCGTGGACGACCCCCTGCCCGACTACTCTCTGCCT 
                   
               
               
                   
                 CCGGTCACCAGCAGCAGCTCGTCGTCCCTGAGTCACGGCGGCGGCGGC 
                   
               
               
                   
                 GGCGGCGGCGGGGGAGGCCAGGAGGCCGGCCACCACCCTGCGGCCCAC 
                   
               
               
                   
                 CAAGGCCGCCTCACCTCGTGGTACCTGAACCAGGCGGGCGGAGACCTG 
                   
               
               
                   
                 GGCCACTTGGCGAGCGCGGCGGCGGCGGCGGCGGCCGCAGGCTACCCG 
                   
               
               
                   
                 GGCCAGCAGCAGAACTTCCACTCGGTGCGGGAGATGTTCGAGTCACAG 
                   
               
               
                   
                 AGGATCGGCTTGAACAACTCTCCAGTGAACGGGAATAGTAGCTGTCAA 
                   
               
               
                   
                 ATGGCCTTCCCTTCCAGCCAGTCTCTGTACCGCACGTCCGGAGCTTTCGT 
                   
               
               
                   
                 CTACGACTGTAGCAAGTTTTGACACACCCTCAAAGCCGAACTAAATCGA 
                   
               
               
                   
                 ACCCCAAAGCAGGAAAAGCTAAAGGAACCCATCAAGGCAAAATCGAA 
                   
               
               
                   
                 ACTAAAAAAAAAAAATCCATTAAAAAAAACCCCTGAGAATATTCACC 
                   
               
               
                   
                 ACACCAGCGAACAGAATATCCCTCCAAAAATTCAGCTCACCAGCACCA 
                   
               
               
                   
                 GCACGAAGAAAACTCTATTTTCTTAACCGATTAATTCAGAGCCACCTCC 
                   
               
               
                   
                 ACTTTGCCTTGTCTAAATAAACAAACCCGTAAACTGTTTTATACAGAGA 
                   
               
               
                   
                 CAGCAAAATCTTGGTTTATTAAAGGACAGTGTTACTCCAGATAACACGT 
                   
               
               
                   
                 AAGTTTCTTCTTGCTTTTCAGAGACCTGCTTTCCCCTCCTCCCGTCTCCCC 
                   
               
               
                   
                 TCTCTTGCCTTCTTCCTTGCCTCTCACCTGTAAGATATTATTTTATCCTAT 
                   
               
               
                   
                 GTTGAAGGGAGGGGGAAAGTCCCCGTTTATGAAAGTCGCTTTCTTTTTA 
                   
               
               
                   
                 TTCATGGACTTGTTTTAAAATGTAAATTGCAACATAGTAATTTATTTTTA 
                   
               
               
                   
                 ATTTGTAGTTGGATGTCGTGGACCAAACGCCAGAAAGTGTTCCCAAAAC 
                   
               
               
                   
                 CTGACGTTAAATTGCCTGAAACTTTAAATTGTGCTTTTTTTCTCATTATA 
                   
               
               
                   
                 AAAAGGGAAACTGTATTAATCTTATTCTATCCTCTTTTCTTTCTTTTTGTT 
                   
               
               
                   
                 GAACATATTCATTGTTTGTTTATTAATAAATTACCATTCAGTTTGAATGA 
                   
               
               
                   
                 GACCTATATGTCTGGATACTTTAATAGAGCTTTAATTATTACGAAAAAA 
                   
               
               
                   
                 GATTTCAGAGATAAAACACTAGAAGTTACCTATTCTCCACCTAAATCTC 
                   
               
               
                   
                 TGAAAAATGGAGAAACCCTCTGACTAGTCCATGTCAAATTTTACTAAAA 
                   
               
               
                   
                 GTCTTTTTGTTTAGATTTATTTTCCTGCAGCATCTTCTGCAAAATGTACT 
                   
               
               
                   
                 ATATAGTCAGCTTGCTTTGAGGCTAGTAAAAAGATATTTTTCTAAACAG 
                   
               
               
                   
                 ATTGGAGTTGGCATATAAACAAATACGTTTTCTCACTAATGACAGTCCA 
                   
               
               
                   
                 TGATTCGGAAATTTTAAGCCCATGAATCAGCCGCGGTCTTACCACGGTG 
                   
               
               
                   
                 ATGCCTGTGTGCCGAGAGATGGGACTGTGCGGCCAGATATGCACAGAT 
                   
               
               
                   
                 AAATATTTGGCTTGTGTATTCCATATAAAATTGCAGTGCATATTATACAT 
                   
               
               
                   
                 CCCTGTGAGCCAGATGCTGAATAGATATTTTCCTATTATTTCAGTCCTTT 
                   
               
               
                   
                 ATAAAAGGAAAAATAAACCAGTTTTTAAATGTATGTATATAATTCTCCC 
                   
               
               
                   
                 CCATTTACAATCCTTCATGTATTACATAGAAGGATTGCTTTTTTAAAAAT 
                   
               
               
                   
                 ATACTGCGGGTTGGAAAGGGATATTTAATCTTTGAGAAACTATTTTAGA 
                   
               
               
                   
                 AAATATGTTTGTAGAACAATTATTTTTGAAAAAGATTTAAAGCAATAAC 
                   
               
               
                   
                 AAGAAGGAAGGCGAGAGGAGCAGAACATTTTGGTCTAGGGTGGTTTCT 
                   
               
               
                   
                 TTTTAAACCATTTTTTCTTGTTAATTTACAGTTAAACCTAGGGGACAATC 
                   
               
               
                   
                 CGGATTGGCCCTCCCCCTTTTGTAAATAACCCAGGAAATGTAATAAATT 
                   
               
               
                   
                 CATTATCTTAGGGTGATCTGCCCTGCCAATCAGACTTTGGGGAGATGGC 
                   
               
               
                   
                 GATTTGATTACAGACGTTCGGGGGGGTGGGGGGCTTGCAGTTTGTTTTG 
                   
               
               
                   
                 GAGATAATACAGTTTCCTGCTATCTGCCGCTCCTATCTAGAGGCAACAC 
                   
               
               
                   
                 TTAAGCAGTAATTGCTGTTGCTTGTTGTCAAAATTTGATCATTGTTAAAG 
                   
               
               
                   
                 GATTGCTGCAAATAAATACACTTTAATTTCAGTCAAAAA 
                   
               
               
                   
               
               
                 AJ249248 
                 GTGGCCTCGAGGTGGTGGCAGGGCCGCCCCCTGCAGTCCGGAGACGAA 
                 170 
               
               
                   
                 CGCACGGACCGGGCCTCCGGAGGCAGGTTCGGCTGGAAGGAACCGCTC 
                   
               
               
                   
                 TCGCTTCGTCCTACACTTGCGCAAATGTCTCCGAGCTTACTCACATAGC 
                   
               
               
                   
                 ATATTGGTATATCAAAATGAAATGCAAGGAACCAAAAATAACATAATT 
                   
               
               
                   
                 GAAGGCAGTAAAAGTGAAATTAAATAGGAAGATCATCAGTCAAGGAAG 
                   
               
               
                   
                 ACCCACTGGAGAGGACAGAAAATGAAGCAGTGTTTTATCATGTGTATTT 
                   
               
               
                   
                 CAGCAGGTCTTCTTGAAATTTAACTAAAAATATGACTGCTCTCTCTTCA 
                   
               
               
                   
                 GAGAACTGCTCTTTTCAGTACCAGTTACGTCAAACAAACCAGCCCCTAG 
                   
               
               
                   
                 ACGTTAACTATCTGCTATTCTTGATCATACTTGGGAAAATATTATTAAAT 
                   
               
               
                   
                 ATCCTTACACTAGGAATGAGAAGAAAAAACACCTGTCAAAATTTTATG 
                   
               
               
                   
                 GAATATTTTTGCATTTCACTAGCATTCGTTGATCTTTTACTTTTGGTAAA 
                   
               
               
                   
                 CATTTCCATTATATTGTATTTCAGGGATTTTGTACTTTTAAGCATTAGGT 
                   
               
               
                   
                 TCACTAAATACCACATCTGCCTATTTACTCAAATTATTTCCTTTACTTAT 
                   
               
               
                   
                 GGCTTTTTGCATTATCCAGTTTTCCTGACAGCTTGTATAGATTATTGCCT 
                   
               
               
                   
                 GAATTTCTCTAAAACAACCAAGCTTTCATTTAAGTGTCAAAAATTATTTT 
                   
               
               
                   
                 ATTTCTTTACAGTAATTTTAATTTGGATTTCAGTCCTTGCTTATGTTTTGG 
                   
               
               
                   
                 GAGACCCAGCCATCTACCAAAGCCTGAAGGCACAGAATGCTTATTCTCG 
                   
               
               
                   
                 TCACTGTCCTTTCTATGTCAGCATTCAGAGTTACTGGCTGTCATTTTTCA 
                   
               
               
                   
                 TGGTGATGATTTTATTTGTAGCTTTCATAACCTGTTGGGAAGAAGTTACT 
                   
               
               
                   
                 ACTTTGGTACAGGCTATCAGGATAACTTCCTATATGAATGAAACTATCT 
                   
               
               
                   
                 TATATTTTCCTTTTTCATCCCACTCCAGTTATACTGTGAGATCTAAAAAA 
                   
               
               
                   
                 ATATTCTTATCCAAGCTCATTGTCTGTTTTCTCAGTACCTGGTTACCATT 
                   
               
               
                   
                 TGTACTACTTCAGGTAATCATTGTTTTACTTAAAGTTCAGATTCCAGCAT 
                   
               
               
                   
                 ATATTGAGATGAATATTCCCTGGTTATACTTTGTCAATAGTTTTCTCATT 
                   
               
               
                   
                 GCTACAGTGTATTGGTTTAATTGTCACAAGCTTAATTTAAAAGACATTG 
                   
               
               
                   
                 GATTACCTTTGGATCCATTTGTCAACTGGAAGTGCTGCTTCATTCCACTT 
                   
               
               
                   
                 ACAATTCCTAATCTTGAGCAAATTGAAAAGCCTATATCAATAATGATTT 
                   
               
               
                   
                 GTTAATATTATTAATTAAAAGTTACAGCTGTCATAAGATCATAATTTTAT 
                   
               
               
                   
                 GAACAGAAAGAACTCAGGACATATTAAAAAATAAACTGAACTAAAACA 
                   
               
               
                   
                 ACTTTTGCCCCCTGACTGATAGCATTTCAGAATGTGTCTTTTGAAGGGCT 
                   
               
               
                   
                 ATACCAGTTATTAAATAGTGTTTTATTTTAAAAACAAAATAATTCCAAG 
                   
               
               
                   
                 AAGTTTTTATAGTTATTCAGGGACACTATATTACAAATATTACTTTGTTA 
                   
               
               
                   
                 TTAACACAAAAAGTGATAAGAGTTAACATTTGGCTATACTGATGTTTGT 
                   
               
               
                   
                 GTTACTCAAAAAAACTACTGGATGCAAACTGTTATGTAAATCTGAGATT 
                   
               
               
                   
                 TCACTGACAACTTTAAGATATCAACCTAAACATTTTTATTAAATGTTCA 
                   
               
               
                   
                 AATGTAAGCAAGAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_005310 
                 ACCCGCCCCCATCTGCCCAAGATAATTTTAGTTTCCTTGGGCCTGGAAT 
                 171 
               
               
                   
                 CTGGACACACAGGGCTCCCCCCCGCCTCTGACTTCTCTGTCCGAAGTCG 
                   
               
               
                   
                 GGACACCCTCCTACCACCTGTAGAGAAGCGGGAGTGGATCTGAAATAA 
                   
               
               
                   
                 AATCCAGGAATCTGGGGGTTCCTAGACGGAGCCAGACTTCGGAACGGG 
                   
               
               
                   
                 TGTCCTGCTACTCCTGCTGGGGCTCCTCCAGGACAAGGGCACACAACTG 
                   
               
               
                   
                 GTTCCGTTAAGCCCCTCTCTCGCTCAGACGCCATGGAGCTGGATCTGTC 
                   
               
               
                   
                 TCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGG 
                   
               
               
                   
                 ACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGG 
                   
               
               
                   
                 TAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCG 
                   
               
               
                   
                 AGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTC 
                   
               
               
                   
                 CCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCT 
                   
               
               
                   
                 CCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAGT 
                   
               
               
                   
                 AAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGC 
                   
               
               
                   
                 AGGTGCCACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCA 
                   
               
               
                   
                 CGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCT 
                   
               
               
                   
                 AGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCA 
                   
               
               
                   
                 GGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAAC 
                   
               
               
                   
                 TTCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAG 
                   
               
               
                   
                 AAAAAATGGTCTCCAGCTGTCTCGATGCACACACTGGTATATCCCATGA 
                   
               
               
                   
                 AGACCTCATCCAGAACTTCCTGAATGCTGGCAGCTTTCCTGAGATCCAG 
                   
               
               
                   
                 GGCTTTCTGCAGCTGCGGGGTTCAGGACGGAAGCTTTGGAAACGCTTTT 
                   
               
               
                   
                 TCTGCTTCTTGCGCCGATCTGGCCTCTATTACTCCACCAAGGGCACCTCT 
                   
               
               
                   
                 AAGGATCCGAGGCACCTGCAGTACGTGGCAGATGTGAACGAGTCCAAC 
                   
               
               
                   
                 GTGTACGTGGTGACGCAGGGCCGCAAGCTCTACGGGATGCCCACTGAC 
                   
               
               
                   
                 TTCGGTTTCTGTGTCAAGCCCAACAAGCTTCGAAATGGCCACAAGGGGC 
                   
               
               
                   
                 TTCGGATCTTCTGCAGTGAAGATGAGCAGAGCCGCACCTGCTGGCTGGC 
                   
               
               
                   
                 TGCCTTCCGCCTCTTCAAGTACGGGGTGCAGCTGTACAAGAATTACCAG 
                   
               
               
                   
                 CAGGCACAGTCTCGCCATCTGCATCCATCTTGTTTGGGCTCCCCACCCTT 
                   
               
               
                   
                 GAGAAGTGCCTCAGATAATACCCTGGTGGCCATGGACTTCTCTGGCCAT 
                   
               
               
                   
                 GCTGGGCGTGTCATTGAGAACCCCCGGGAGGCTCTGAGTGTGGCCCTGG 
                   
               
               
                   
                 AGGAGGCCCAGGCCTGGAGGAAGAAGACAAACCACCGCCTCAGCCTGC 
                   
               
               
                   
                 CCATGCCAGCCTCCGGCACGAGCCTCAGTGCAGCCATCCACCGCACCCA 
                   
               
               
                   
                 ACTCTGGTTCCACGGGCGCATTTCCCGTGAGGAGAGCCAGCGGCTTATT 
                   
               
               
                   
                 GGACAGCAGGGCTTGGTAGACGGCCTGTTCCTGGTCCGGGAGAGTCAG 
                   
               
               
                   
                 CGGAACCCCCAGGGCTTTGTCCTCTCTTTGTGCCACCTGCAGAAAGTGA 
                   
               
               
                   
                 AGCATTATCTCATCCTGCCGAGCGAGGAGGAGGGCCGCCTGTACTTCAG 
                   
               
               
                   
                 CATGGATGATGGCCAGACCCGCTTCACTGACCTGCTGCAGCTCGTGGAG 
                   
               
               
                   
                 TTCCACCAGCTGAACCGCGGCATCCTGCCGTGCTTGCTGCGCCATTGCT 
                   
               
               
                   
                 GCACGCGGGTGGCCCTCTGACCAGGCCGTGGACTGGCTCATGCCTCAGC 
                   
               
               
                   
                 CCGCCTTCAGGCTGCCCGCCGCCCCTCCACCCATCCAGTGGACTCTGGG 
                   
               
               
                   
                 GCGCGGCCACAGGGGACGGGATGAGGAGCGGGAGGGTTCCGCCACTCC 
                   
               
               
                   
                 AGTTTTCTCCTCTGCTTCTTTGCCTCCCTCAGATAGAAAACAGCCCCCAC 
                   
               
               
                   
                 TCCAGTCCACTCCTGACCCCTCTCCTCAAGGGAAGGCCTTGGGTGGCCC 
                   
               
               
                   
                 CCTCTCCTTCTCCTAGCTCTGGAGGTGCTGCTCTAGGGCAGGGAATTAT 
                   
               
               
                   
                 GGGAGAAGTGGGGGCAGCCCAGGCGGTTTCACGCCCCACACTTTGTAC 
                   
               
               
                   
                 AGACCGAGAGGCCAGTTGATCTGCTCTGTTTTATACTAGTGACAATAAA 
                   
               
               
                   
                 GATTATTTTTTGATACAAAAAAAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_014176 
                 AGTCAGAGGTCGCGCAGGCGCTGGTACCCCGTTGGTCCGCGCGTTGCTG 
                 172 
               
               
                   
                 CGTTGTGAGGGGTGTCAGCTCAGTGCATCCCAGGCAGCTCTTAGTGTGG 
                   
               
               
                   
                 AGCAGTGAACTGTGTGTGGTTCCTTCTACTTGGGGATCATGCAGAGAGC 
                   
               
               
                   
                 TTCACGTCTGAAGAGAGAGCTGCACATGTTAGCCACAGAGCCACCCCC 
                   
               
               
                   
                 AGGCATCACATGTTGGCAAGATAAAGACCAAATGGATGACCTGCGAGC 
                   
               
               
                   
                 TCAAATATTAGGTGGAGCCAACACACCTTATGAGAAAGGTGTTTTTAAG 
                   
               
               
                   
                 CTAGAAGTTATCATTCCTGAGAGGTACCCATTTGAACCTCCTCAGATCC 
                   
               
               
                   
                 GATTTCTCACTCCAATTTATCATCCAAACATTGATTCTGCTGGAAGGATT 
                   
               
               
                   
                 TGTCTGGATGTTCTCAAATTGCCACCAAAAGGTGCTTGGAGACCATCCC 
                   
               
               
                   
                 TCAACATCGCAACTGTGTTGACCTCTATTCAGCTGCTCATGTCAGAACC 
                   
               
               
                   
                 CAACCCTGATGACCCGCTCATGGCTGACATATCCTCAGAATTTAAATAT 
                   
               
               
                   
                 AATAAGCCAGCCTTCCTCAAGAATGCCAGACAGTGGACAGAGAAGCAT 
                   
               
               
                   
                 GCAAGACAGAAACAAAAGGCTGATGAGGAAGAGATGCTTGATAATCTA 
                   
               
               
                   
                 CCAGAGGCTGGTGACTCCAGAGTACACAACTCAACACAGAAAAGGAAG 
                   
               
               
                   
                 GCCAGTCAGCTAGTAGGCATAGAAAAGAAATTTCATCCTGATGTTTAGG 
                   
               
               
                   
                 GGACTTGTCCTGGTTCATCTTAGTTAATGTGTTCTTTGCCAAGGTGATCT 
                   
               
               
                   
                 AAGTTGCCTACCTTGAATTTTTTTTTAAATATATTTGATGACATAATTTT 
                   
               
               
                   
                 TGTGTAGTTTATTTATCTTGTACATATGTATTTTGAAATCTTTTAAACCT 
                   
               
               
                   
                 GAAAAATAAATAGTCATTTAATGTTGAAAAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
                 AAAAAAA 
                   
               
               
                   
               
               
                 NM_006845 
                 ACGCTTGCGCGCGGGATTTAAACTGCGGCGGTTTACGCGGCGTTAAGAC 
                 173 
               
               
                   
                 TTCGTAGGGTTAGCGAAATTGAGGTTTCTTGGTATTGCGCGTTTCTCTTC 
                   
               
               
                   
                 CTTGCTGACTCTCCGAATGGCCATGGACTCGTCGCTTCAGGCCCGCCTG 
                   
               
               
                   
                 TTTCCCGGTCTCGCTATCAAGATCCAACGCAGTAATGGTTTAATTCACA 
                   
               
               
                   
                 GTGCCAATGTAAGGACTGTGAACTTGGAGAAATCCTGTGTTTCAGTGGA 
                   
               
               
                   
                 ATGGGCAGAAGGAGGTGCCACAAAGGGCAAAGAGATTGATTTTGATGA 
                   
               
               
                   
                 TGTGGCTGCAATAAACCCAGAACTCTTACAGCTTCTTCCCTTACATCCG 
                   
               
               
                   
                 AAGGACAATCTGCCCTTGCAGGAAAATGTAACAATCCAGAAACAAAAA 
                   
               
               
                   
                 CGGAGATCCGTCAACTCCAAAATTCCTGCTCCAAAAGAAAGTCTTCGAA 
                   
               
               
                   
                 GCCGCTCCACTCGCATGTCCACTGTCTCAGAGCTTCGCATCACGGCTCA 
                   
               
               
                   
                 GGAGAATGACATGGAGGTGGAGCTGCCTGCAGCTGCAAACTCCCGCAA 
                   
               
               
                   
                 GCAGTTTTCAGTTCCTCCTGCCCCCACTAGGCCTTCCTGCCCTGCAGTGG 
                   
               
               
                   
                 CTGAAATACCATTGAGGATGGTCAGCGAGGAGATGGAAGAGCAAGTCC 
                   
               
               
                   
                 ATTCCATCCGAGGCAGCTCTTCTGCAAACCCTGTGAACTCAGTTCGGAG 
                   
               
               
                   
                 GAAATCATGTCTTGTGAAGGAAGTGGAAAAAATGAAGAACAAGCGAGA 
                   
               
               
                   
                 AGAGAAGAAGGCCCAGAACTCTGAAATGAGAATGAAGAGAGCTCAGG 
                   
               
               
                   
                 AGTATGACAGTAGTTTTCCAAACTGGGAATTTGCCCGAATGATTAAAGA 
                   
               
               
                   
                 ATTTCGGGCTACTTTGGAATGTCATCCACTTACTATGACTGATCCTATCG 
                   
               
               
                   
                 AAGAGCACAGAATATGTGTCTGTGTTAGGAAACGCCCACTGAATAAGC 
                   
               
               
                   
                 AAGAATTGGCCAAGAAAGAAATTGATGTGATTTCCATTCCTAGCAAGTG 
                   
               
               
                   
                 TCTCCTCTTGGTACATGAACCCAAGTTGAAAGTGGACTTAACAAAGTAT 
                   
               
               
                   
                 CTGGAGAACCAAGCATTCTGCTTTGACTTTGCATTTGATGAAACAGCTT 
                   
               
               
                   
                 CGAATGAAGTTGTCTACAGGTTCACAGCAAGGCCACTGGTACAGACAA 
                   
               
               
                   
                 TCTTTGAAGGTGGAAAAGCAACTTGTTTTGCATATGGCCAGACAGGAAG 
                   
               
               
                   
                 TGGCAAGACACATACTATGGGCGGAGACCTCTCTGGGAAAGCCCAGAA 
                   
               
               
                   
                 TGCATCCAAAGGGATCTATGCCATGGCCTCCCGGGACGTCTTCCTCCTG 
                   
               
               
                   
                 AAGAATCAACCCTGCTACCGGAAGTTGGGCCTGGAAGTCTATGTGACAT 
                   
               
               
                   
                 TCTTCGAGATCTACAATGGGAAGCTGTTTGACCTGCTCAACAAGAAGGC 
                   
               
               
                   
                 CAAGCTGCGCGTGCTGGAGGACGGCAAGCAACAGGTGCAAGTGGTGGG 
                   
               
               
                   
                 GCTGCAGGAGCATCTGGTTAACTCTGCTGATGATGTCATCAAGATGATC 
                   
               
               
                   
                 GACATGGGCAGCGCCTGCAGAACCTCTGGGCAGACATTTGCCAACTCC 
                   
               
               
                   
                 AATTCCTCCCGCTCCCACGCGTGCTTCCAAATTATTCTTCGAGCTAAAG 
                   
               
               
                   
                 GGAGAATGCATGGCAAGTTCTCTTTGGTAGATCTGGCAGGGAATGAGC 
                   
               
               
                   
                 GAGGCGCGGACACTTCCAGTGCTGACCGGCAGACCCGCATGGAGGGCG 
                   
               
               
                   
                 CAGAAATCAACAAGAGTCTCTTAGCCCTGAAGGAGTGCATCAGGGCCC 
                   
               
               
                   
                 TGGGACAGAACAAGGCTCACACCCCGTTCCGTGAGAGCAAGCTGACAC 
                   
               
               
                   
                 AGGTGCTGAGGGACTCCTTCATTGGGGAGAACTCTAGGACTTGCATGAT 
                   
               
               
                   
                 TGCCACGATCTCACCAGGCATAAGCTCCTGTGAATATACTTTAAACACC 
                   
               
               
                   
                 CTGAGATATGCAGACAGGGTCAAGGAGCTGAGCCCCCACAGTGGGCCC 
                   
               
               
                   
                 AGTGGAGAGCAGTTGATTCAAATGGAAACAGAAGAGATGGAAGCCTGC 
                   
               
               
                   
                 TCTAACGGGGCGCTGATTCCAGGCAATTTATCCAAGGAAGAGGAGGAA 
                   
               
               
                   
                 CTGTCTTCCCAGATGTCCAGCTTTAACGAAGCCATGACTCAGATCAGGG 
                   
               
               
                   
                 AGCTGGAGGAGAAGGCTATGGAAGAGCTCAAGGAGATCATACAGCAA 
                   
               
               
                   
                 GGACCAGACTGGCTTGAGCTCTCTGAGATGACCGAGCAGCCAGACTAT 
                   
               
               
                   
                 GACCTGGAGACCTTTGTGAACAAAGCGGAATCTGCTCTGGCCCAGCAA 
                   
               
               
                   
                 GCCAAGCATTTCTCAGCCCTGCGAGATGTCATCAAGGCCTTGCGCCTGG 
                   
               
               
                   
                 CCATGCAGCTGGAAGAGCAGGCTAGCAGACAAATAAGCAGCAAGAAA 
                   
               
               
                   
                 CGGCCCCAGTGACGACTGCAAATAAAAATCTGTTTGGTTTGACACCCAG 
                   
               
               
                   
                 CCTCTTCCCTGGCCCTCCCCAGAGAACTTTGGGTACCTGGTGGGTCTAG 
                   
               
               
                   
                 GCAGGGTCTGAGCTGGGACAGGTTCTGGTAAATGCCAAGTATGGGGGC 
                   
               
               
                   
                 ATCTGGGCCCAGGGCAGCTGGGGAGGGGGTCAGAGTGACATGGGACAC 
                   
               
               
                   
                 TCCTTTTCTGTTCCTCAGTTGTCGCCCTCACGAGAGGAAGGAGCTCTTAG 
                   
               
               
                   
                 TTACCCTTTTGTGTTGCCCTTCTTTCCATCAAGGGGAATGTTCTCAGCAT 
                   
               
               
                   
                 AGAGCTTTCTCCGCAGCATCCTGCCTGCGTGGACTGGCTGCTAATGGAG 
                   
               
               
                   
                 AGCTCCCTGGGGTTGTCCTGGCTCTGGGGAGAGAGACGGAGCCTTTAGT 
                   
               
               
                   
                 ACAGCTATCTGCTGGCTCTAAACCTTCTACGCCTTTGGGCCGAGCACTG 
                   
               
               
                   
                 AATGTCTTGTACTTTAAAAAAATGTTTCTGAGACCTCTTTCTACTTTACT 
                   
               
               
                   
                 GTCTCCCTAGAGATCCTAGAGGATCCCTACTGTTTTCTGTTTTATGTGTT 
                   
               
               
                   
                 TATACATTGTATGTAACAATAAAGAGAAAAAATAAATCAGCTGTTTAA 
                   
               
               
                   
                 GTGTGTGGAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_006101 
                 ACTGCGCGCGTCGTGCGTAATGACGTCAGCGCCGGCGGAGAATTTCAA 
                 174 
               
               
                   
                 ATTCGAACGGCTTTGGCGGGCCGAGGAAGGACCTGGTGTTTTGATGACC 
                   
               
               
                   
                 GCTGTCCTGTCTAGCAGATACTTGCACGGTTTACAGAAATTCGGTCCCT 
                   
               
               
                   
                 GGGTCGTGTCAGGAAACTGGAAAAAAGGTCATAAGCATGAAGCGCAGT 
                   
               
               
                   
                 TCAGTTTCCAGCGGTGGTGCTGGCCGCCTCTCCATGCAGGAGTTAAGAT 
                   
               
               
                   
                 CCCAGGATGTAAATAAACAAGGCCTCTATACCCCTCAAACCAAAGAGA 
                   
               
               
                   
                 AACCAACCTTTGGAAAGTTGAGTATAAACAAACCGACATCTGAAAGAA 
                   
               
               
                   
                 AAGTCTCGCTATTTGGCAAAAGAACTAGTGGACATGGATCCCGGAATA 
                   
               
               
                   
                 GTCAACTTGGTATATTTTCCAGTTCTGAGAAAATCAAGGACCCGAGACC 
                   
               
               
                   
                 ACTTAATGACAAAGCATTCATTCAGCAGTGTATTCGACAACTCTGTGAG 
                   
               
               
                   
                 TTTCTTACAGAAAATGGTTATGCACATAATGTGTCCATGAAATCTCTAC 
                   
               
               
                   
                 AAGCTCCCTCTGTTAAAGACTTCCTGAAGATCTTCACATTTCTTTATGGC 
                   
               
               
                   
                 TTCCTGTGCCCCTCATACGAACTTCCTGACACAAAGTTTGAAGAAGAGG 
                   
               
               
                   
                 TTCCAAGAATCTTTAAAGACCTTGGGTATCCTTTTGCACTATCCAAAAG 
                   
               
               
                   
                 CTCCATGTACACAGTGGGGGCTCCTCATACATGGCCTCACATTGTGGCA 
                   
               
               
                   
                 GCCTTAGTTTGGCTAATAGACTGCATCAAGATACATACTGCCATGAAAG 
                   
               
               
                   
                 AAAGCTCACCTTTATTTGATGATGGGCAGCCTTGGGGAGAAGAAACTG 
                   
               
               
                   
                 AAGATGGAATTATGCATAATAAGTTGTTTTTGGACTACACCATAAAATG 
                   
               
               
                   
                 CTATGAGAGTTTTATGAGTGGTGCCGACAGCTTTGATGAGATGAATGCA 
                   
               
               
                   
                 GAGCTGCAGTCAAAACTGAAGGATTTATTTAATGTGGATGCTTTTAAGC 
                   
               
               
                   
                 TGGAATCATTAGAAGCAAAAAACAGAGCATTGAATGAACAGATTGCAA 
                   
               
               
                   
                 GATTGGAACAAGAAAGAGAAAAAGAACCGAATCGTCTAGAGTCGTTGA 
                   
               
               
                   
                 GAAAACTGAAGGCTTCCTTACAAGGAGATGTTCAAAAGTATCAGGCAT 
                   
               
               
                   
                 ACATGAGCAATTTGGAGTCTCATTCAGCCATTCTTGACCAGAAATTAAA 
                   
               
               
                   
                 TGGTCTCAATGAGGAAATTGCTAGAGTAGAACTAGAATGTGAAACAAT 
                   
               
               
                   
                 AAAACAGGAGAACACTCGACTACAGAATATCATTGACAACCAGAAGTA 
                   
               
               
                   
                 CTCAGTTGCAGACATTGAGCGAATAAATCATGAAAGAAATGAATTGCA 
                   
               
               
                   
                 GCAGACTATTAATAAATTAACCAAGGACCTGGAAGCTGAACAACAGAA 
                   
               
               
                   
                 GTTGTGGAATGAGGAGTTAAAATATGCCAGAGGCAAAGAAGCGATTGA 
                   
               
               
                   
                 AACACAATTAGCAGAGTATCACAAATTGGCTAGAAAATTAAAACTTATT 
                   
               
               
                   
                 CCTAAAGGTGCTGAGAATTCCAAAGGTTATGACTTTGAAATTAAGTTTA 
                   
               
               
                   
                 ATCCCGAGGCTGGTGCCAACTGCCTTGTCAAATACAGGGCTCAAGTTTA 
                   
               
               
                   
                 TGTACCTCTTAAGGAACTCCTGAATGAAACTGAAGAAGAAATTAATAA 
                   
               
               
                   
                 AGCCCTAAATAAAAAAATGGGTTTGGAGGATACTTTAGAACAATTGAA 
                   
               
               
                   
                 TGCAATGATAACAGAAAGCAAGAGAAGTGTGAGAACTCTGAAAGAAG 
                   
               
               
                   
                 AAGTTCAAAAGCTGGATGATCTTTACCAACAAAAAATTAAGGAAGCAG 
                   
               
               
                   
                 AGGAAGAGGATGAAAAATGTGCCAGTGAGCTTGAGTCCTTGGAGAAAC 
                   
               
               
                   
                 ACAAGCACCTGCTAGAAAGTACTGTTAACCAGGGGCTCAGTGAAGCTA 
                   
               
               
                   
                 TGAATGAATTAGATGCTGTTCAGCGGGAATACCAACTAGTTGTGCAAAC 
                   
               
               
                   
                 CACGACTGAAGAAAGACGAAAAGTGGGAAATAACTTGCAACGTCTGTT 
                   
               
               
                   
                 AGAGATGGTTGCTACACATGTTGGGTCTGTAGAGAAACATCTTGAGGA 
                   
               
               
                   
                 GCAGATTGCTAAAGTTGATAGAGAATATGAAGAATGCATGTCAGAAGA 
                   
               
               
                   
                 TCTCTCGGAAAATATTAAAGAGATTAGAGATAAGTATGAGAAGAAAGC 
                   
               
               
                   
                 TACTCTAATTAAGTCTTCTGAAGAATGAAGATAAAATGTTGATCATGTA 
                   
               
               
                   
                 TATATATCCATAGTGAATAAAATTGTCTCAGTAAAGTGTAAAAAAAAA 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 BC042437 
                 CTCCCTCCTCTGCACCATGACTACCTGCAGCCGCCAGTTCACCTCCTCCA 
                 175 
               
               
                   
                 GCTCCATGAAGGGCTCCTGCGGCATCGGGGGCGGCATCGGGGGCGGCT 
                   
               
               
                   
                 CCAGCCGCATCTCCTCCGTCCTGGCCGGAGGGTCCTGCCGCGCCCCCAG 
                   
               
               
                   
                 CACCTACGGGGGCGGCCTGTCTGTCTCATCCTCCCGCTTCTCCTCTGGGG 
                   
               
               
                   
                 GAGCCTATGGGTTGGGGGGCGGCTATGGCGGTGGCTTCAGCAGCAGCA 
                   
               
               
                   
                 GCAGCAGCTTTGGTAGTGGCTTTGGGGGAGGATATGGTGGTGGCCTTGG 
                   
               
               
                   
                 TGCTGGCTTGGGTGGTGGCTTTGGTGGTGGCTTTGCTGGTGGTGATGGG 
                   
               
               
                   
                 CTTCTGGTGGGCAGTGAGAAGGTGACCATGCAGAACCTCAACGACCGC 
                   
               
               
                   
                 CTGGCCTCCTACCTGGACAAGGTGCGTGCTCTGGAGGAGGCCAACGCC 
                   
               
               
                   
                 GACCTGGAAGTGAAGATCCGTGACTGGTACCAGAGGCAGCGGCCTGCT 
                   
               
               
                   
                 GAGATCAAAGACTACAGTCCCTACTTCAAGACCATTGAGGACCTGAGG 
                   
               
               
                   
                 AACAAGATTCTCACAGCCACAGTGGACAATGCCAATGTCCTTCTGCAGA 
                   
               
               
                   
                 TTGACAATGCCCGTCTGGCCGCGGATGACTTCCGCACCAAGTATGAGAC 
                   
               
               
                   
                 AGAGTTGAACCTGCGCATGAGTGTGGAAGCCGACATCAATGGCCTGCG 
                   
               
               
                   
                 CAGGGTGCTGGACGAACTGACCCTGGCCAGAGCTGACCTGGAGATGCA 
                   
               
               
                   
                 GATTGAGAGCCTGAAGGAGGAGCTGGCCTACCTGAAGAAGAACCACGA 
                   
               
               
                   
                 GGAGGAGATGAATGCCCTGAGAGGCCAGGTGGGTGGAGATGTCAATGT 
                   
               
               
                   
                 GGAGATGGACGCTGCACCTGGCGTGGACCTGAGCCGCATTCTGAACGA 
                   
               
               
                   
                 GATGCGTGACCAGTATGAGAAGATGGCAGAGAAGAACCGCAAGGATGC 
                   
               
               
                   
                 CGAGGAATGGTTCTTCACCAAGACAGAGGAGCTGAACCGCGAGGTGGC 
                   
               
               
                   
                 CACCAACAGCGAGCTGGTGCAGAGCGGCAAGAGCGAGATCTCGGAGCT 
                   
               
               
                   
                 CCGGCGCACCATGCAGAACCTGGAGATTGAGCTGCAGTCCCAGCTCAG 
                   
               
               
                   
                 CATGAAAGCATCCCTGGAGAACAGCCTGGAGGAGACCAAAGGTCGCTA 
                   
               
               
                   
                 CTGCATGCAGCTGGCCCAGATCCAGGAGATGATTGGCAGCGTGGAGGA 
                   
               
               
                   
                 GCAGCTGGCCCAGCTCCGCTGCGAGATGGAGCAGCAGAACCAGGAGTA 
                   
               
               
                   
                 CAAGATCCTGCTGGACGTGAAGACGCGGCTGGAGCAGGAGATCGCCAC 
                   
               
               
                   
                 CTACCGCCGCCTGCTGGAGGGCGAGGACGCCCACCTCTCCTCCTCCCAG 
                   
               
               
                   
                 TTCTCCTCTGGATCGCAGTCATCCAGAGATGTGACCTCCTCCAGCCGCC 
                   
               
               
                   
                 AAATCCGCACCAAGGTCATGGATGTGCACGATGGCAAGGTGGTGTCCA 
                   
               
               
                   
                 CCCACGAGCAGGTCCTTCGCACCAAGAACTGAGGCTGCCCAGCCCCGCT 
                   
               
               
                   
                 CAGGCCTAGGAGGCCCCCCGTGTGGACACAGATCCCACTGGAAGATCC 
                   
               
               
                   
                 CCTCTCCTGCCCAAGCACTTCACAGCTGGACCCTGCTTCACCCTCACCCC 
                   
               
               
                   
                 CTCCTGGCAATCAATACAGCTTCATTATCTGAGTTGCATAAAAAAAAAA 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
                 AAA 
                   
               
               
                   
               
               
                 AK095281 
                 CTCTTTTGCAGGGGCCGTTCCTCGGGGCATGACGCTGGCTCCTGCACAG 
                 176 
               
               
                   
                 ATCCTGCTCCTCTGTGGCCTTCCTGGGCTGCCCTCCCCTCCTCCGGGACT 
                   
               
               
                   
                 GCTCTGGACTGACACTGCTCAGGTTCGGATTCCCTCAAAGACTTTGGGA 
                   
               
               
                   
                 GACAAGACTTGGTCCCCCTTTTACAAACAAGGGAACGGAGGCTCTAGA 
                   
               
               
                   
                 ACTGACTTCCTGAAAGGCTTGGATCCAAAGCTCCCTCAGTTCAGCGGCC 
                   
               
               
                   
                 ACGTCTATTTCCCTCAGACACAGGGATCCTTGAACCTGTGGGCTGTATC 
                   
               
               
                   
                 TCCCCGCGGACTTGGAAGAATCCCAAGAGAGTGGGGCTCCCACAGGCT 
                   
               
               
                   
                 GGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCCACCTCCCAGGT 
                   
               
               
                   
                 TCAAGCTATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGATC 
                   
               
               
                   
                 CTGGTGGCTGTGGTCGGTAATTCCAGCTTCGTGCTGGCTACAGGTGGAT 
                   
               
               
                   
                 GATGCCCACCTGGCTGCCGATGACCTCTGCACCAAGTGAGGCTGGGTCT 
                   
               
               
                   
                 CTGGAGCTGCCCCAGGGGCTGGACAAGCTGACCCTGGCCGGGGCCAAC 
                   
               
               
                   
                 CTGGAGATGCAGATTGAGAACCTCAAGGAGGACCTGGTCTACCTGAAG 
                   
               
               
                   
                 AAGAACCACAAGCAGGAAATGAACGTCCTTTGAGGTCAGGTGGATGAG 
                   
               
               
                   
                 GATGTCAGTGTGAAGATGGACACTGTGCCTGGAGTGAACCTGAGCTGC 
                   
               
               
                   
                 ATCCTGAATGAGATGCGTGACCAGGACAAGACATTGGTGGAGAAGAGC 
                   
               
               
                   
                 TGCAAGGATGCCGAGGGCTGGTTCTTCAGCATGGTGGGTGGCCGTGCGT 
                   
               
               
                   
                 AAGCAGGTGTGTACACGTGTGGGCACATGTGCTGCATGCTGGTGCAGCT 
                   
               
               
                   
                 GGAGCACTGGCAGATCCACAGGCTGTCCCAGTTGGAAGGACTTTTGGA 
                   
               
               
                   
                 AACCAGTTGGACCAGCCCCTCATGTTTTAGATGTAAAACGTGAGGCTCA 
                   
               
               
                   
                 GAGAGGACTCAAGCTCACACAGCCCTTCACTGTGGCCTGCAAAATAGA 
                   
               
               
                   
                 TCCAGGTCTCTACAAGTCTGGTCTTGGGTTTCCACCACAGCTGTTTACAG 
                   
               
               
                   
                 GATGTGCGTATTTGAATACATATGTATACCCTTGGCAAGCACAGGCTGA 
                   
               
               
                   
                 GTATCTCCGGTATCCTAGGGACAGCAACAGGCGCAAAAGAATAACACC 
                   
               
               
                   
                 CAGTGCCTGTCTTTGAGGTGCTGCAGTTCAGTAGGAAAAAGAAATGCA 
                   
               
               
                   
                 AATGACCGCAGAGCAGGCTGAATTCCTCCAAGTTCCAATGTGGGTGCA 
                   
               
               
                   
                 GAGGCTCTCTGTGTGCAGAAAGAGGGGCTGAACTGCGAGGTGGCCACC 
                   
               
               
                   
                 AACACAGAGGCCCTGCAGAGTGGCTGGATAGAGATATGGAGCTCTACG 
                   
               
               
                   
                 TCTCTGTGCAGAACCTGAGCCGTCCCAGCTCAGCAAGAAAGCATCGCTG 
                   
               
               
                   
                 GAGGGCAGCCTGGTGGAGATGGAGGTGTGTTACAGGACCCTGCCGGCC 
                   
               
               
                   
                 CAGCTGCAGGGGCTTAACAGAAGCATGGAGCAGCAGCTGTGCGAGCTC 
                   
               
               
                   
                 TGCTGCGACACGGAGCACCAGGACCACAAGCACAGGTCCTTCTGGACG 
                   
               
               
                   
                 TGAAGACGTGGCTGGAGCAGGAGATCGCCACCTACCGCCGCTTGCTGG 
                   
               
               
                   
                 AGGTTGAGGACGCCCAGAGGTGATACTGACGATGCAGGCTGGAGTCTG 
                   
               
               
                   
                 GCTGAGGAGCCTTGAATGCCAAGTTAAAGCGTCTGGACTAGATCACGT 
                   
               
               
                   
                 AGGCAATGGGGAGCCATGGAGGGATTTGGAGCAGGAGAGTGAAATGA 
                   
               
               
                   
                 ACATCAAGAGATTTTAGAACATTCACTCTGGCTGCAGAGGGAGAAATG 
                   
               
               
                   
                 GATCAGAGGGGTCAGGGCGGGGCCAGAGAGATGTGTCAGGGGGCTGG 
                   
               
               
                   
                 AGCAGGGAGTCTGGCCAGAGAAGTCCCGTGCGGTGGTGGGTAGTGGGG 
                   
               
               
                   
                 CAGGGGAAGGAAGGTGGTGCACGCAGAAGAGAGGTTATAGCTCAAAA 
                   
               
               
                   
                 CAGCGGGACTGGATGCCTGGATCTCGGGGTAAGCATGGCTCACAGTCA 
                   
               
               
                   
                 GGACTCAGTAAGTGTCGGGAGAACACATGAAGGAGCAGGCATTGATGG 
                   
               
               
                   
                 CCCTGGGTTTCTGGTTCTGATGACTGTGTGAGTGGTGAAGAGCAAGGTG 
                   
               
               
                   
                 GGTGGTGGTTGGGTTTGCAGTTGGGAAGGGTGATCAGGCCTTCAGCTGA 
                   
               
               
                   
                 GAGTGTCCCGGAGTCTCCATGCTTAGTCACACGTTGCAGCTTTTTGCTCC 
                   
               
               
                   
                 CCGGAAATGGTGAAGTCCATCTATAGTCTAACAACAGTCTCTCCTGCTT 
                   
               
               
                   
                 TAATTGGGTCTATTTGTTGGGCCCTCTGGGTTATGGAAAAACCACTTGC 
                   
               
               
                   
                 TCAGCTTCTCCTTGTAAATTCCTGGTGAGTAGCCACAGAGTGCCGCCAG 
                   
               
               
                   
                 ACCTACTGCTGTGCTGTTTCTTTTTCTTCTTCCTGCTGTGCTGAACCCCTG 
                   
               
               
                   
                 CCCTTTCATTCTTGGGCCTGCGCTAATTTCTGTGCATTCCCAACTGTGAT 
                   
               
               
                   
                 TTTTCACCAATTTAGGGGAACCTCCTCTGCCAGGGCCTACTTCTCCCCAG 
                   
               
               
                   
                 CAGTGCTTGCAGGTGCCTGGGCTGGCTGGCATCCCTGGGCTGATGGGTG 
                   
               
               
                   
                 CTTCTCTCCCTGCAGGCTGGCCACTCAGTACTCCTTGTCCCTGGCCTCGC 
                   
               
               
                   
                 AGCCCACCCGGGAAGCCACAGTGACCAGCCACCAGGTGTGCCATCGTG 
                   
               
               
                   
                 GAGGAAGTCCAGGTTGGAGAGGTGGTCTTCTTCTGTGAGCAGGTCCACT 
                   
               
               
                   
                 TCTCCACCCACTGAGACCCCTTTCTGTCTGCGACAGCCCCACCTCGAGG 
                   
               
               
                   
                 GCCACGGCACAGCCATCAGCTCCAGCTCCCAGCATGCTACTGCCACGCC 
                   
               
               
                   
                 CCGAGTGTCCGTCTGGGCCCCGGTGCATGGCCTGTTGTCTTTCTGTATCT 
                   
               
               
                   
                 ACTTTCTGCAGCCCCTCACTGAGGAGGCCTCCTGGGTTTGTCCAGTGCC 
                   
               
               
                   
                 TACTATTAAAGCTTTGCTCCAAGTTC 
                   
               
               
                   
               
               
                 M21389 
                 GCATCCTTTTTGGGCTGCTCACAGCCCCCAGCCTCTATGGTGAAGACAT 
                 177 
               
               
                   
                 ACTTGCTAGCAGCGTCACCAACTTGCTGCCAAGAGATCAGTGCTGCAAG 
                   
               
               
                   
                 GCAAGGTTATTTCTAACTGAGCAGAGCCTGCCAGGAAGAAAGCGTTTG 
                   
               
               
                   
                 CACCCCACACCACTGTGCAGGTGTGACCGGTGAGCTCACAGCTGCCCCC 
                   
               
               
                   
                 CAGGCATGCCCAGCCCACTTAATCATTCACAGCTCGACAGCTCTCTCGC 
                   
               
               
                   
                 CCAGCCCAGTTCTGGAAGGGATAAAAAGGGGGCATCACCGTTCCTGGG 
                   
               
               
                   
                 TAACAGAGCCACCTTCTGCGTCCTGCTGAGCTCTGTTCTCTCCAGCACCT 
                   
               
               
                   
                 CCCAACCCACTAGTGCCTGGTTCTCTTGCTCCACCAGGAACAAGCCACC 
                   
               
               
                   
                 ATGTCTCGCCAGTCAAGTGTGTCCTTCCGGAGCGGGGGCAGTCGTAGCT 
                   
               
               
                   
                 TCAGCACCGCCTCTGCCATCACCCCGTCTGTCTCCCGCACCAGCTTCACC 
                   
               
               
                   
                 TCCGTGTCCCGGTCCGGGGGTGGCGGTGGTGGTGGCTTCGGCAGGGTCA 
                   
               
               
                   
                 GCCTTGCGGGTGCTTGTGGAGTGGGTGGCTATGGCAGCCGGAGCCTCTA 
                   
               
               
                   
                 CAACCTGGGGGGCTCCAAGAGGATATCCATCAGCACTAGAGGAGGCAG 
                   
               
               
                   
                 CTTCAGGAACCGGTTTGGTGCTGGTGCTGGAGGCGGCTATGGCTTTGGA 
                   
               
               
                   
                 GGTGGTGCCGGTAGTGGATTTGGTTTCGGCGGTGGAGCTGGTGGTGGCT 
                   
               
               
                   
                 TTGGGCTCGGTGGCGGAGCTGGCTTTGGAGGTGGCTTCGGTGGCCCTGG 
                   
               
               
                   
                 CTTTCCTGTCTGCCCTCCTGGAGGTATCCAAGAGGTCACTGTCAACCAG 
                   
               
               
                   
                 AGTCTCCTGACTCCCCTCAACCTGCAAATCGACCCCAGCATCCAGAGGG 
                   
               
               
                   
                 TGAGGACCGAGGAGCGCGAGCAGATCAAGACCCTCAACAATAAGTTTG 
                   
               
               
                   
                 CCTCCTTCATCGACAAGGTGCGGTTCCTGGAGCAGCAGAACAAGGTTCT 
                   
               
               
                   
                 GGACACCAAGTGGACCCTGCTGCAGGAGCAGGGCACCAAGACTGTGAG 
                   
               
               
                   
                 GCAGAACCTGGAGCCGTTGTTCGAGCAGTACATCAACAACCTCAGGAG 
                   
               
               
                   
                 GCAGCTGGACAGCATCGTGGGGGAACGGGGCCGCCTGGACTCAGAGCT 
                   
               
               
                   
                 GAGAAACATGCAGGACCTGGTGGAAGACTTCAAGAACAAGTATGAGGA 
                   
               
               
                   
                 TGAAATCAACAAGCGTACCACTGCTGAGAATGAGTTTGTGATGCTGAA 
                   
               
               
                   
                 GAAGGATGTAGATGCTGCCTACATGAACAAGGTGGAGCTGGAGGCCAA 
                   
               
               
                   
                 GGTTGATGCACTGATGGATGAGATTAACTTCATGAAGATGTTCTTTGAT 
                   
               
               
                   
                 GCGGAGCTGTCCCAGATGCAGACGCATGTCTCTGACACCTCAGTGGTCC 
                   
               
               
                   
                 TCTCCATGGACAACAACCGCAACCTGGACCTGGATAGCATCATCGCTGA 
                   
               
               
                   
                 GGTCAAGGCCCAGTATGAGGAGATTGCCAACCGCAGCCGGACAGAAGC 
                   
               
               
                   
                 CGAGTCCTGGTATCAGACCAAGTATGAGGAGCTGCAGCAGACAGCTGG 
                   
               
               
                   
                 CCGGCATGGCGATGACCTCCGCAACACCAAGCATGAGATCACAGAGAT 
                   
               
               
                   
                 GAACCGGATGATCCAGAGGCTGAGAGCCGAGATTGACAATGTCAAGAA 
                   
               
               
                   
                 ACAGTGCGCCAATCTGCAGAACGCCATTGCGGATGCCGAGCAGCGTGG 
                   
               
               
                   
                 GGAGCTGGCCCTCAAGGATGCCAGGAACAAGCTGGCCGAGCTGGAGGA 
                   
               
               
                   
                 GGCCCTGCAGAAGGCCAAGCAGGACATGGCCCGGCTGCTGCGTGAGTA 
                   
               
               
                   
                 CCAGGAGCTCATGAACACCAAGCTGGCCCTGGACGTGGAGATCGCCAC 
                   
               
               
                   
                 TTACCGCAAGCTGCTGGAGGGCGAGGAATGCAGACTCAGTGGAGAAGG 
                   
               
               
                   
                 AGTTGGACCAGTCAACATCTCTGTTGTCACAAGCAGTGTTTCCTCTGGA 
                   
               
               
                   
                 TATGGCAGTGGCAGTGGCTATGGCGGTGGCCTCGGTGGAGGTCTTGGCG 
                   
               
               
                   
                 GCGGCCTCGGTGGAGGTCTTGCCGGAGGTAGCAGTGGAAGCTACTACT 
                   
               
               
                   
                 CCAGCAGCAGTGGGGGTGTCGGCCTAGGTGGTGGGCTCAGTGTGGGGG 
                   
               
               
                   
                 GCTCTGGCTTCAGTGCAAGCAGTGGCCGAGGGCTGGGGGTGGGCTTTG 
                   
               
               
                   
                 GCAGTGGCGGGGGTAGCAGCTCCAGCGTCAAATTTGTCTCCACCACCTC 
                   
               
               
                   
                 CTCCTCCCGGAAGAGCTTCAAGAGCTAAGAACCTGCTGCAAGTCACTGC 
                   
               
               
                   
                 CTTCCAAGTGCAGCAACCCAGCCCATGGAGATTGCCTCTTCTAGGCAGT 
                   
               
               
                   
                 TGCTCAAGCCATGTTTTATCCTTTTCTGGAGAGTAGTCTAGACCAAGCC 
                   
               
               
                   
                 AATTGCAGAACCACATTCTTTGGTTCCCAGGAGAGCCCCATTCCCAGCC 
                   
               
               
                   
                 CCTGGTCTCCCGTGCCGCAGTTCTATATTCTGCTTCAAATCAGCCTTCAG 
                   
               
               
                   
                 GTTTCCCACAGCATGGCCCCTGCTGACACGAGAACCCAAAGTTTTCCCA 
                   
               
               
                   
                 AATCTAAATCATCAAAACAGAATCCCCACCCCAATCCCAAATTTTGTTT 
                   
               
               
                   
                 TGGTTCTAACTACCTCCAGAATGTGTTCAATAAAATGCTTTTATAATAT 
                   
               
               
                   
               
               
                 NM_001123066 
                 GGACGGCCGAGCGGCAGGGCGCTCGCGCGCGCCCACTAGTGGCCGGAG 
                 178 
               
               
                   
                 GAGAAGGCTCCCGCGGAGGCCGCGCTGCCCGCCCCCTCCCCTGGGGAG 
                   
               
               
                   
                 GCTCGCGTTCCCGCTGCTCGCGCCTGCGCCGCCCGCCGGCCTCAGGAAC 
                   
               
               
                   
                 GCGCCCTCTTCGCCGGCGCGCGCCCTCGCAGTCACCGCCACCCACCAGC 
                   
               
               
                   
                 TCCGGCACCAACAGCAGCGCCGCTGCCACCGCCCACCTTCTGCCGCCGC 
                   
               
               
                   
                 CACCACAGCCACCTTCTCCTCCTCCGCTGTCCTCTCCCGTCCTCGCCTCT 
                   
               
               
                   
                 GTCGACTATCAGGTGAACTTTGAACCAGGATGGCTGAGCCCCGCCAGG 
                   
               
               
                   
                 AGTTCGAAGTGATGGAAGATCACGCTGGGACGTACGGGTTGGGGGACA 
                   
               
               
                   
                 GGAAAGATCAGGGGGGCTACACCATGCACCAAGACCAAGAGGGTGAC 
                   
               
               
                   
                 ACGGACGCTGGCCTGAAAGAATCTCCCCTGCAGACCCCCACTGAGGAC 
                   
               
               
                   
                 GGATCTGAGGAACCGGGCTCTGAAACCTCTGATGCTAAGAGCACTCCA 
                   
               
               
                   
                 ACAGCGGAAGATGTGACAGCACCCTTAGTGGATGAGGGAGCTCCCGGC 
                   
               
               
                   
                 AAGCAGGCTGCCGCGCAGCCCCACACGGAGATCCCAGAAGGAACCACA 
                   
               
               
                   
                 GCTGAAGAAGCAGGCATTGGAGACACCCCCAGCCTGGAAGACGAAGCT 
                   
               
               
                   
                 GCTGGTCACGTGACCCAAGAGCCTGAAAGTGGTAAGGTGGTCCAGGAA 
                   
               
               
                   
                 GGCTTCCTCCGAGAGCCAGGCCCCCCAGGTCTGAGCCACCAGCTCATGT 
                   
               
               
                   
                 CCGGCATGCCTGGGGCTCCCCTCCTGCCTGAGGGCCCCAGAGAGGCCAC 
                   
               
               
                   
                 ACGCCAACCTTCGGGGACAGGACCTGAGGACACAGAGGGCGGCCGCCA 
                   
               
               
                   
                 CGCCCCTGAGCTGCTCAAGCACCAGCTTCTAGGAGACCTGCACCAGGA 
                   
               
               
                   
                 GGGGCCGCCGCTGAAGGGGGCAGGGGGCAAAGAGAGGCCGGGGAGCA 
                   
               
               
                   
                 AGGAGGAGGTGGATGAAGACCGCGACGTCGATGAGTCCTCCCCCCAAG 
                   
               
               
                   
                 ACTCCCCTCCCTCCAAGGCCTCCCCAGCCCAAGATGGGCGGCCTCCCCA 
                   
               
               
                   
                 GACAGCCGCCAGAGAAGCCACCAGCATCCCAGGCTTCCCAGCGGAGGG 
                   
               
               
                   
                 TGCCATCCCCCTCCCTGTGGATTTCCTCTCCAAAGTTTCCACAGAGATCC 
                   
               
               
                   
                 CAGCCTCAGAGCCCGACGGGCCCAGTGTAGGGCGGGCCAAAGGGCAGG 
                   
               
               
                   
                 ATGCCCCCCTGGAGTTCACGTTTCACGTGGAAATCACACCCAACGTGCA 
                   
               
               
                   
                 GAAGGAGCAGGCGCACTCGGAGGAGCATTTGGGAAGGGCTGCATTTCC 
                   
               
               
                   
                 AGGGGCCCCTGGAGAGGGGCCAGAGGCCCGGGGCCCCTCTTTGGGAGA 
                   
               
               
                   
                 GGACACAAAAGAGGCTGACCTTCCAGAGCCCTCTGAAAAGCAGCCTGC 
                   
               
               
                   
                 TGCTGCTCCGCGGGGGAAGCCCGTCAGCCGGGTCCCTCAACTCAAAGCT 
                   
               
               
                   
                 CGCATGGTCAGTAAAAGCAAAGACGGGACTGGAAGCGATGACAAAAA 
                   
               
               
                   
                 AGCCAAGACATCCACACGTTCCTCTGCTAAAACCTTGAAAAATAGGCCT 
                   
               
               
                   
                 TGCCTTAGCCCCAAACACCCCACTCCTGGTAGCTCAGACCCTCTGATCC 
                   
               
               
                   
                 AACCCTCCAGCCCTGCTGTGTGCCCAGAGCCACCTTCCTCTCCTAAATA 
                   
               
               
                   
                 CGTCTCTTCTGTCACTTCCCGAACTGGCAGTTCTGGAGCAAAGGAGATG 
                   
               
               
                   
                 AAACTCAAGGGGGCTGATGGTAAAACGAAGATCGCCACACCGCGGGGA 
                   
               
               
                   
                 GCAGCCCCTCCAGGCCAGAAGGGCCAGGCCAACGCCACCAGGATTCCA 
                   
               
               
                   
                 GCAAAAACCCCGCCCGCTCCAAAGACACCACCCAGCTCTGCGACTAAG 
                   
               
               
                   
                 CAAGTCCAGAGAAGACCACCCCCTGCAGGGCCCAGATCTGAGAGAGGT 
                   
               
               
                   
                 GAACCTCCAAAATCAGGGGATCGCAGCGGCTACAGCAGCCCCGGCTCC 
                   
               
               
                   
                 CCAGGCACTCCCGGCAGCCGCTCCCGCACCCCGTCCCTTCCAACCCCAC 
                   
               
               
                   
                 CCACCCGGGAGCCCAAGAAGGTGGCAGTGGTCCGTACTCCACCCAAGT 
                   
               
               
                   
                 CGCCGTCTTCCGCCAAGAGCCGCCTGCAGACAGCCCCCGTGCCCATGCC 
                   
               
               
                   
                 AGACCTGAAGAATGTCAAGTCCAAGATCGGCTCCACTGAGAACCTGAA 
                   
               
               
                   
                 GCACCAGCCGGGAGGCGGGAAGGTGCAGATAATTAATAAGAAGCTGGA 
                   
               
               
                   
                 TCTTAGCAACGTCCAGTCCAAGTGTGGCTCAAAGGATAATATCAAACAC 
                   
               
               
                   
                 GTCCCGGGAGGCGGCAGTGTGCAAATAGTCTACAAACCAGTTGACCTG 
                   
               
               
                   
                 AGCAAGGTGACCTCCAAGTGTGGCTCATTAGGCAACATCCATCATAAAC 
                   
               
               
                   
                 CAGGAGGTGGCCAGGTGGAAGTAAAATCTGAGAAGCTTGACTTCAAGG 
                   
               
               
                   
                 ACAGAGTCCAGTCGAAGATTGGGTCCCTGGACAATATCACCCACGTCCC 
                   
               
               
                   
                 TGGCGGAGGAAATAAAAAGATTGAAACCCACAAGCTGACCTTCCGCGA 
                   
               
               
                   
                 GAACGCCAAAGCCAAGACAGACCACGGGGCGGAGATCGTGTACAAGTC 
                   
               
               
                   
                 GCCAGTGGTGTCTGGGGACACGTCTCCACGGCATCTCAGCAATGTCTCC 
                   
               
               
                   
                 TCCACCGGCAGCATCGACATGGTAGACTCGCCCCAGCTCGCCACGCTAG 
                   
               
               
                   
                 CTGACGAGGTGTCTGCCTCCCTGGCCAAGCAGGGTTTGTGATCAGGCCC 
                   
               
               
                   
                 CTGGGGCGGTCAATAATTGTGGAGAGGAGAGAATGAGAGAGTGTGGAA 
                   
               
               
                   
                 AAAAAAAGAATAATGACCCGGCCCCCGCCCTCTGCCCCCAGCTGCTCCT 
                   
               
               
                   
                 CGCAGTTCGGTTAATTGGTTAATCACTTAACCTGCTTTTGTCACTCGGCT 
                   
               
               
                   
                 TTGGCTCGGGACTTCAAAATCAGTGATGGGAGTAAGAGCAAATTTCATC 
                   
               
               
                   
                 TTTCCAAATTGATGGGTGGGCTAGTAATAAAATATTTAAAAAAAAACAT 
                   
               
               
                   
                 TCAAAAACATGGCCACATCCAACATTTCCTCAGGCAATTCCTTTTGATT 
                   
               
               
                   
                 CTTTTTTCTTCCCCCTCCATGTAGAAGAGGGAGAAGGAGAGGCTCTGAA 
                   
               
               
                   
                 AGCTGCTTCTGGGGGATTTCAAGGGACTGGGGGTGCCAACCACCTCTGG 
                   
               
               
                   
                 CCCTGTTGTGGGGGTGTCACAGAGGCAGTGGCAGCAACAAAGGATTTG 
                   
               
               
                   
                 AAACTTGGTGTGTTCGTGGAGCCACAGGCAGACGATGTCAACCTTGTGT 
                   
               
               
                   
                 GAGTGTGACGGGGGTTGGGGTGGGGCGGGAGGCCACGGGGGAGGCCG 
                   
               
               
                   
                 AGGCAGGGGCTGGGCAGAGGGGAGAGGAAGCACAAGAAGTGGGAGTG 
                   
               
               
                   
                 GGAGAGGAAGCCACGTGCTGGAGAGTAGACATCCCCCTCCTTGCCGCT 
                   
               
               
                   
                 GGGAGAGCCAAGGCCTATGCCACCTGCAGCGTCTGAGCGGCCGCCTGT 
                   
               
               
                   
                 CCTTGGTGGCCGGGGGTGGGGGCCTGCTGTGGGTCAGTGTGCCACCCTC 
                   
               
               
                   
                 TGCAGGGCAGCCTGTGGGAGAAGGGACAGCGGGTAAAAAGAGAAGGC 
                   
               
               
                   
                 AAGCTGGCAGGAGGGTGGCACTTCGTGGATGACCTCCTTAGAAAAGAC 
                   
               
               
                   
                 TGACCTTGATGTCTTGAGAGCGCTGGCCTCTTCCTCCCTCCCTGCAGGGT 
                   
               
               
                   
                 AGGGGGCCTGAGTTGAGGGGCTTCCCTCTGCTCCACAGAAACCCTGTTT 
                   
               
               
                   
                 TATTGAGTTCTGAAGGTTGGAACTGCTGCCATGATTTTGGCCACTTTGC 
                   
               
               
                   
                 AGACCTGGGACTTTAGGGCTAACCAGTTCTCTTTGTAAGGACTTGTGCC 
                   
               
               
                   
                 TCTTGGGAGACGTCCACCCGTTTCCAAGCCTGGGCCACTGGCATCTCTG 
                   
               
               
                   
                 GAGTGTGTGGGGGTCTGGGAGGCAGGTCCCGAGCCCCCTGTCCTTCCCA 
                   
               
               
                   
                 CGGCCACTGCAGTCACCCCGTCTGCGCCGCTGTGCTGTTGTCTGCCGTG 
                   
               
               
                   
                 AGAGCCCAATCACTGCCTATACCCCTCATCACACGTCACAATGTCCCGA 
                   
               
               
                   
                 ATTCCCAGCCTCACCACCCCTTCTCAGTAATGACCCTGGTTGGTTGCAG 
                   
               
               
                   
                 GAGGTACCTACTCCATACTGAGGGTGAAATTAAGGGAAGGCAAAGTCC 
                   
               
               
                   
                 AGGCACAAGAGTGGGACCCCAGCCTCTCACTCTCAGTTCCACTCATCCA 
                   
               
               
                   
                 ACTGGGACCCTCACCACGAATCTCATGATCTGATTCGGTTCCCTGTCTCC 
                   
               
               
                   
                 TCCTCCCGTCACAGATGTGAGCCAGGGCACTGCTCAGCTGTGACCCTAG 
                   
               
               
                   
                 GTGTTTCTGCCTTGTTGACATGGAGAGAGCCCTTTCCCCTGAGAAGGCC 
                   
               
               
                   
                 TGGCCCCTTCCTGTGCTGAGCCCACAGCAGCAGGCTGGGTGTCTTGGTT 
                   
               
               
                   
                 GTCAGTGGTGGCACCAGGATGGAAGGGCAAGGCACCCAGGGCAGGCCC 
                   
               
               
                   
                 ACAGTCCCGCTGTCCCCCACTTGCACCCTAGCTTGTAGCTGCCAACCTC 
                   
               
               
                   
                 CCAGACAGCCCAGCCCGCTGCTCAGCTCCACATGCATAGTATCAGCCCT 
                   
               
               
                   
                 CCACACCCGACAAAGGGGAACACACCCCCTTGGAAATGGTTCTTTTCCC 
                   
               
               
                   
                 CCAGTCCCAGCTGGAAGCCATGCTGTCTGTTCTGCTGGAGCAGCTGAAC 
                   
               
               
                   
                 ATATACATAGATGTTGCCCTGCCCTCCCCATCTGCACCCTGTTGAGTTGT 
                   
               
               
                   
                 AGTTGGATTTGTCTGTTTATGCTTGGATTCACCAGAGTGACTATGATAGT 
                   
               
               
                   
                 GAAAAGAAAAAAAAAAAAAAAAAAGGACGCATGTATCTTGAAATGCTT 
                   
               
               
                   
                 GTAAAGAGGTTTCTAACCCACCCTCACGAGGTGTCTCTCACCCCCACAC 
                   
               
               
                   
                 TGGGACTCGTGTGGCCTGTGTGGTGCCACCCTGCTGGGGCCTCCCAAGT 
                   
               
               
                   
                 TTTGAAAGGCTTTCCTCAGCACCTGGGACCCAACAGAGACCAGCTTCTA 
                   
               
               
                   
                 GCAGCTAAGGAGGCCGTTCAGCTGTGACGAAGGCCTGAAGCACAGGAT 
                   
               
               
                   
                 TAGGACTGAAGCGATGATGTCCCCTTCCCTACTTCCCCTTGGGGCTCCCT 
                   
               
               
                   
                 GTGTCAGGGCACAGACTAGGTCTTGTGGCTGGTCTGGCTTGCGGCGCGA 
                   
               
               
                   
                 GGATGGTTCTCTCTGGTCATAGCCCGAAGTCTCATGGCAGTCCCAAAGG 
                   
               
               
                   
                 AGGCTTACAACTCCTGCATCACAAGAAAAAGGAAGCCACTGCCAGCTG 
                   
               
               
                   
                 GGGGGATCTGCAGCTCCCAGAAGCTCCGTGAGCCTCAGCCACCCCTCAG 
                   
               
               
                   
                 ACTGGGTTCCTCTCCAAGCTCGCCCTCTGGAGGGGCAGCGCAGCCTCCC 
                   
               
               
                   
                 ACCAAGGGCCCTGCGACCACAGCAGGGATTGGGATGAATTGCCTGTCC 
                   
               
               
                   
                 TGGATCTGCTCTAGAGGCCCAAGCTGCCTGCCTGAGGAAGGATGACTTG 
                   
               
               
                   
                 ACAAGTCAGGAGACACTGTTCCCAAAGCCTTGACCAGAGCACCTCAGC 
                   
               
               
                   
                 CCGCTGACCTTGCACAAACTCCATCTGCTGCCATGAGAAAAGGGAAGC 
                   
               
               
                   
                 CGCCTTTGCAAAACATTGCTGCCTAAAGAAACTCAGCAGCCTCAGGCCC 
                   
               
               
                   
                 AATTCTGCCACTTCTGGTTTGGGTACAGTTAAAGGCAACCCTGAGGGAC 
                   
               
               
                   
                 TTGGCAGTAGAAATCCAGGGCCTCCCCTGGGGCTGGCAGCTTCGTGTGC 
                   
               
               
                   
                 AGCTAGAGCTTTACCTGAAAGGAAGTCTCTGGGCCCAGAACTCTCCACC 
                   
               
               
                   
                 AAGAGCCTCCCTGCCGTTCGCTGAGTCCCAGCAATTCTCCTAAGTTGAA 
                   
               
               
                   
                 GGGATCTGAGAAGGAGAAGGAAATGTGGGGTAGATTTGGTGGTGGTTA 
                   
               
               
                   
                 GAGATATGCCCCCCTCATTACTGCCAACAGTTTCGGCTGCATTTCTTCAC 
                   
               
               
                   
                 GCACCTCGGTTCCTCTTCCTGAAGTTCTTGTGCCCTGCTCTTCAGCACCA 
                   
               
               
                   
                 TGGGCCTTCTTATACGGAAGGCTCTGGGATCTCCCCCTTGTGGGGCAGG 
                   
               
               
                   
                 CTCTTGGGGCCAGCCTAAGATCATGGTTTAGGGTGATCAGTGCTGGCAG 
                   
               
               
                   
                 ATAAATTGAAAAGGCACGCTGGCTTGTGATCTTAAATGAGGACAATCCC 
                   
               
               
                   
                 CCCAGGGCTGGGCACTCCTCCCCTCCCCTCACTTCTCCCACCTGCAGAG 
                   
               
               
                   
                 CCAGTGTCCTTGGGTGGGCTAGATAGGATATACTGTATGCCGGCTCCTT 
                   
               
               
                   
                 CAAGCTGCTGACTCACTTTATCAATAGTTCCATTTAAATTGACTTCAGTG 
                   
               
               
                   
                 GTGAGACTGTATCCTGTTTGCTATTGCTTGTTGTGCTATGGGGGGAGGG 
                   
               
               
                   
                 GGGAGGAATGTGTAAGATAGTTAACATGGGCAAAGGGAGATCTTGGGG 
                   
               
               
                   
                 TGCAGCACTTAAACTGCCTCGTAACCCTTTTCATGATTTCAACCACATTT 
                   
               
               
                   
                 GCTAGAGGGAGGGAGCAGCCACGGAGTTAGAGGCCCTTGGGGTTTCTC 
                   
               
               
                   
                 TTTTCCACTGACAGGCTTTCCCAGGCAGCTGGCTAGTTCATTCCCTCCCC 
                   
               
               
                   
                 AGCCAGGTGCAGGCGTAGGAATATGGACATCTGGTTGCTTTGGCCTGCT 
                   
               
               
                   
                 GCCCTCTTTCAGGGGTCCTAAGCCCACAATCATGCCTCCCTAAGACCTT 
                   
               
               
                   
                 GGCATCCTTCCCTCTAAGCCGTTGGCACCTCTGTGCCACCTCTCACACTG 
                   
               
               
                   
                 GCTCCAGACACACAGCCTGTGCTTTTGGAGCTGAGATCACTCGCTTCAC 
                   
               
               
                   
                 CCTCCTCATCTTTGTTCTCCAAGTAAAGCCACGAGGTCGGGGCGAGGGC 
                   
               
               
                   
                 AGAGGTGATCACCTGCGTGTCCCATCTACAGACCTGCAGCTTCATAAAA 
                   
               
               
                   
                 CTTCTGATTTCTCTTCAGCTTTGAAAAGGGTTACCCTGGGCACTGGCCTA 
                   
               
               
                   
                 GAGCCTCACCTCCTAATAGACTTAGCCCCATGAGTTTGCCATGTTGAGC 
                   
               
               
                   
                 AGGACTATTTCTGGCACTTGCAAGTCCCATGATTTCTTCGGTAATTCTGA 
                   
               
               
                   
                 GGGTGGGGGGAGGGACATGAAATCATCTTAGCTTAGCTTTCTGTCTGTG 
                   
               
               
                   
                 AATGTCTATATAGTGTATTGTGTGTTTTAACAAATGATTTACACTGACTG 
                   
               
               
                   
                 TTGCTGTAAAAGTGAATTTGGAAATAAAGTTATTACTCTGATTAAA 
                   
               
               
                   
               
               
                 M92424 
                 GCACCGCGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTC 
                 179 
               
               
                   
                 GGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGCGACCCCT 
                   
               
               
                   
                 CTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCG 
                   
               
               
                   
                 GATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCCGGAGAGTGGAATGA 
                   
               
               
                   
                 TCCCCGAGGCCCAGGGCGTCGTGCTTCCGCAGTAGTCAGTCCCCGTGAA 
                   
               
               
                   
                 GGAAACTGGGGAGTCTTGAGGGACCCCCGACTCCAAGCGCGAAAACCC 
                   
               
               
                   
                 CGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCT 
                   
               
               
                   
                 ACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGA 
                   
               
               
                   
                 CCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGG 
                   
               
               
                   
                 TGCACAAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGC 
                   
               
               
                   
                 CAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTG 
                   
               
               
                   
                 TATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTC 
                   
               
               
                   
                 TCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTG 
                   
               
               
                   
                 GTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTG 
                   
               
               
                   
                 AGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTAC 
                   
               
               
                   
                 AAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACC 
                   
               
               
                   
                 ATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTC 
                   
               
               
                   
                 AGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAG 
                   
               
               
                   
                 TATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAG 
                   
               
               
                   
                 ATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCG 
                   
               
               
                   
                 AATCCGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGG 
                   
               
               
                   
                 ATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATC 
                   
               
               
                   
                 TCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTC 
                   
               
               
                   
                 AGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGA 
                   
               
               
                   
                 GAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGAC 
                   
               
               
                   
                 TATTGGAAATGCACTTCATGCAATGAAATGAATCCCCCCCTTCCATCAC 
                   
               
               
                   
                 ATTGCAACAGATGTTGGGCCCTTCGTGAGAATTGGCTTCCTGAAGATAA 
                   
               
               
                   
                 AGGGAAAGATAAAGGGGAAATCTCTGAGAAAGCCAAACTGGAAAACT 
                   
               
               
                   
                 CAACACAAGCTGAAGAGGGCTTTGATGTTCCTGATTGTAAAAAAACTAT 
                   
               
               
                   
                 AGTGAATGATTCCAGAGAGTCATGTGTTGAGGAAAATGATGATAAAAT 
                   
               
               
                   
                 TACACAAGCTTCACAATCACAAGAAAGTGAAGACTATTCTCAGCCATCA 
                   
               
               
                   
                 ACTTCTAGTAGCATTATTTATAGCAGCCAAGAAGATGTGAAAGAGTTTG 
                   
               
               
                   
                 AAAGGGAAGAAACCCAAGACAAAGAAGAGAGTGTGGAATCTAGTTTGC 
                   
               
               
                   
                 CCCTTAATGCCATTGAACCTTGTGTGATTTGTCAAGGTCGACCTAAAAA 
                   
               
               
                   
                 TGGTTGCATTGTCCATGGCAAAACAGGACATCTTATGGCCTGCTTTACA 
                   
               
               
                   
                 TGTGCAAAGAAGCTAAAGAAAAGGAATAAGCCCTGCCCAGTATGTAGA 
                   
               
               
                   
                 CAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGTTGACCTGTCT 
                   
               
               
                   
                 ATAAGAGAATTATATATTTCTAACTATATAACCCTAGGAATTTAGACAA 
                   
               
               
                   
                 CCTGAAATTTATTCACATATATCAAAGTGAGAAAATGCCTCAATTCACA 
                   
               
               
                   
                 TAGATTTCTTCTCTTTAGTATAATTGACCTACTTTGGTAGTGGAATAGTG 
                   
               
               
                   
                 AATACTTACTATAATTTGACTTGAATATGTAGCTCATCCTTTACACCAAC 
                   
               
               
                   
                 TCCTAATTTTAAATAATTTCTACTCTGTCTTAAATGAGAAGTACTTGGTT 
                   
               
               
                   
                 TTTTTTTTCTTAAATATGTATATGACATTTAAATGTAACTTATTATTTTTT 
                   
               
               
                   
                 TTGAGACCGAGTCTTGCTCTGTTACCCAGGCTGGAGTGCAGTGGGTGAT 
                   
               
               
                   
                 CTTGGCTCACTGCAAGCTCTGCCCTCCCCGGGTTCGCACCATTCTCCTGC 
                   
               
               
                   
                 CTCAGCCTCCCAATTAGCTTGGCCTACAGTCATCTGCCACCACACCTGG 
                   
               
               
                   
                 CTAATTTTTTGTACTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGG 
                   
               
               
                   
                 ATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAA 
                   
               
               
                   
                 GTGCTGGGATTACAGGCATGAGCCACCG 
                   
               
               
                   
               
               
                 NM_014791 
                 GAGATTTGATTCCCTTGGCGGGCGGAAGCGGCCACAACCCGGCGATCG 
                 180 
               
               
                   
                 AAAAGATTCTTAGGAACGCCGTACCAGCCGCGTCTCTCAGGACAGCAG 
                   
               
               
                   
                 GCCCCTGTCCTTCTGTCGGGCGCCGCTCAGCCGTGCCCTCCGCCCCTCA 
                   
               
               
                   
                 GGTTCTTTTTCTAATTCCAAATAAACTTGCAAGAGGACTATGAAAGATT 
                   
               
               
                   
                 ATGATGAACTTCTCAAATATTATGAATTACATGAAACTATTGGGACAGG 
                   
               
               
                   
                 TGGCTTTGCAAAGGTCAAACTTGCCTGCCATATCCTTACTGGAGAGATG 
                   
               
               
                   
                 GTAGCTATAAAAATCATGGATAAAAACACACTAGGGAGTGATTTGCCC 
                   
               
               
                   
                 CGGATCAAAACGGAGATTGAGGCCTTGAAGAACCTGAGACATCAGCAT 
                   
               
               
                   
                 ATATGTCAACTCTACCATGTGCTAGAGACAGCCAACAAAATATTCATGG 
                   
               
               
                   
                 TTCTTGAGTACTGCCCTGGAGGAGAGCTGTTTGACTATATAATTTCCCA 
                   
               
               
                   
                 GGATCGCCTGTCAGAAGAGGAGACCCGGGTTGTCTTCCGTCAGATAGTA 
                   
               
               
                   
                 TCTGCTGTTGCTTATGTGCACAGCCAGGGCTATGCTCACAGGGACCTCA 
                   
               
               
                   
                 AGCCAGAAAATTTGCTGTTTGATGAATATCATAAATTAAAGCTGATTGA 
                   
               
               
                   
                 CTTTGGTCTCTGTGCAAAACCCAAGGGTAACAAGGATTACCATCTACAG 
                   
               
               
                   
                 ACATGCTGTGGGAGTCTGGCTTATGCAGCACCTGAGTTAATACAAGGCA 
                   
               
               
                   
                 AATCATATCTTGGATCAGAGGCAGATGTTTGGAGCATGGGCATACTGTT 
                   
               
               
                   
                 ATATGTTCTTATGTGTGGATTTCTACCATTTGATGATGATAATGTAATGG 
                   
               
               
                   
                 CTTTATACAAGAAGATTATGAGAGGAAAATATGATGTTCCCAAGTGGCT 
                   
               
               
                   
                 CTCTCCCAGTAGCATTCTGCTTCTTCAACAAATGCTGCAGGTGGACCCA 
                   
               
               
                   
                 AAGAAACGGATTTCTATGAAAAATCTATTGAACCATCCCTGGATCATGC 
                   
               
               
                   
                 AAGATTACAACTATCCTGTTGAGTGGCAAAGCAAGAATCCTTTTATTCA 
                   
               
               
                   
                 CCTCGATGATGATTGCGTAACAGAACTTTCTGTACATCACAGAAACAAC 
                   
               
               
                   
                 AGGCAAACAATGGAGGATTTAATTTCACTGTGGCAGTATGATCACCTCA 
                   
               
               
                   
                 CGGCTACCTATCTTCTGCTTCTAGCCAAGAAGGCTCGGGGAAAACCAGT 
                   
               
               
                   
                 TCGTTTAAGGCTTTCTTCTTTCTCCTGTGGACAAGCCAGTGCTACCCCAT 
                   
               
               
                   
                 TCACAGACATCAAGTCAAATAATTGGAGTCTGGAAGATGTGACCGCAA 
                   
               
               
                   
                 GTGATAAAAATTATGTGGCGGGATTAATAGACTATGATTGGTGTGAAG 
                   
               
               
                   
                 ATGATTTATCAACAGGTGCTGCTACTCCCCGAACATCACAGTTTACCAA 
                   
               
               
                   
                 GTACTGGACAGAATCAAATGGGGTGGAATCTAAATCATTAACTCCAGC 
                   
               
               
                   
                 CTTATGCAGAACACCTGCAAATAAATTAAAGAACAAAGAAAATGTATA 
                   
               
               
                   
                 TACTCCTAAGTCTGCTGTAAAGAATGAAGAGTACTTTATGTTTCCTGAG 
                   
               
               
                   
                 CCAAAGACTCCAGTTAATAAGAACCAGCATAAGAGAGAAATACTCACT 
                   
               
               
                   
                 ACGCCAAATCGTTACACTACACCCTCAAAAGCTAGAAACCAGTGCCTG 
                   
               
               
                   
                 AAAGAAACTCCAATTAAAATACCAGTAAATTCAACAGGAACAGACAAG 
                   
               
               
                   
                 TTAATGACAGGTGTCATTAGCCCTGAGAGGCGGTGCCGCTCAGTGGAAT 
                   
               
               
                   
                 TGGATCTCAACCAAGCACATATGGAGGAGACTCCAAAAAGAAAGGGAG 
                   
               
               
                   
                 CCAAAGTGTTTGGGAGCCTTGAAAGGGGGTTGGATAAGGTTATCACTGT 
                   
               
               
                   
                 GCTCACCAGGAGCAAAAGGAAGGGTTCTGCCAGAGACGGGCCCAGAAG 
                   
               
               
                   
                 ACTAAAGCTTCACTATAACGTGACTACAACTAGATTAGTGAATCCAGAT 
                   
               
               
                   
                 CAACTGTTGAATGAAATAATGTCTATTCTTCCAAAGAAGCATGTTGACT 
                   
               
               
                   
                 TTGTACAAAAGGGTTATACACTGAAGTGTCAAACACAGTCAGATTTTGG 
                   
               
               
                   
                 GAAAGTGACAATGCAATTTGAATTAGAAGTGTGCCAGCTTCAAAAACC 
                   
               
               
                   
                 CGATGTGGTGGGTATCAGGAGGCAGCGGCTTAAGGGCGATGCCTGGGT 
                   
               
               
                   
                 TTACAAAAGATTAGTGGAAGACATCCTATCTAGCTGCAAGGTATAATTG 
                   
               
               
                   
                 ATGGATTCTTCCATCCTGCCGGATGAGTGTGGGTGTGATACAGCCTACA 
                   
               
               
                   
                 TAAAGACTGTTATGATCGCTTTGATTTTAAAGTTCATTGGAACTACCAA 
                   
               
               
                   
                 CTTGTTTCTAAAGAGCTATCTTAAGACCAATATCTCTTTGTTTTTAAACA 
                   
               
               
                   
                 AAAGATATTATTTTGTGTATGAATCTAAATCAAGCCCATCTGTCATTAT 
                   
               
               
                   
                 GTTACTGTCTTTTTTAATCATGTGGTTTTGTATATTAATAATTGTTGACTT 
                   
               
               
                   
                 TCTTAGATTCACTTCCATATGTGAATGTAAGCTCTTAACTATGTCTCTTT 
                   
               
               
                   
                 GTAATGTGTAATTTCTTTCTGAAATAAAACCATTTGTGAATATAG 
                   
               
               
                   
               
               
                 BG765502 
                 GCAGCGGAGGAGCCCAGTCCACGATGGCCCGGTCCCTGGTGTGCCTTG 
                 181 
               
               
                   
                 GTGTCATCATCTTGCTGTCTGCCTTCTCCGGACCTGGTGTCAGGGGTGGT 
                   
               
               
                   
                 CCTATGCCCAAGCTGGCTGACCGGAAGCTGTGTGCGGACCAGGAGTGC 
                   
               
               
                   
                 AGCCACCCTATCTCCATGGCTGTGGCCCTTCAGGACTACATGGCCCCCG 
                   
               
               
                   
                 ACTGCCGATTCCTGACCATTCACCGGGGCCAAGTGGTGTATGTCTTCTC 
                   
               
               
                   
                 CAAGCTGAAGGGCCGTGGGCGGCTCTTCTGGGGAGGCAGCGTTCAGGG 
                   
               
               
                   
                 AGATTACTATGGAGATCTGGCTGCTCGCCTGGGCTATTTCCCCAGTAGC 
                   
               
               
                   
                 ATTGTCCGAGAGGACCAGACCCTGAAACCTGGCAAAGTCGATGTGAAG 
                   
               
               
                   
                 ACAGACAAATGGGATTTCTACTGCCAGTGAGCTCAGCCTACCGCTGGCC 
                   
               
               
                   
                 CTGCCGTTTCCCCTCCTTGGGTTTATGCAAATACAATCAGCCCAGTGCA 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAAAAAAAACTTCGGAGAAGAGATAGCAACAAA 
                   
               
               
                   
                 AGGCCGCTTGTGTGAAGGCGCCAAAAGTTTTCGCCCAAGAGACCTTCGG 
                   
               
               
                   
                 CCTCCCCCAGGGCGCGCGCAAAGGCGCCTTGTTTTGACAACCTCTTGGA 
                   
               
               
                   
                 CAACCGGAGGGGCTACCGCCCGGAGACCCCTGTGGTGGACCCCCCGGG 
                   
               
               
                   
                 CAACCCGGTGTGACAGGGTACTCACCCCCACGGCTTTGTCGGGGGTCCC 
                   
               
               
                   
                 ACCAAAGGCCCCAAAGAGGCTCTTTCAAGGCACTATTCCTTGTTGTAGA 
                   
               
               
                   
                 CCTTGTGTGTGCCACAGGCGCCAAAGAAACCTCGGGGGGCTAACAAAC 
                   
               
               
                   
                 GCACGTGCTTGGCAGCTCCGAGAAGGCTCTCTCCCACCCGAGGGGTGG 
                   
               
               
                   
                 ACGCAACAGGGGGAATGGGCCATCATATTGTTGCCCCCGGTGGGCACC 
                   
               
               
                   
                 AACTCTTTTTCCCCCATAGAGAGGCCTTAGCACACTATGTGGGGCACGT 
                   
               
               
                   
                 TATTGCCGCCTAGAGAAACCGAGCGCCAGAAAATTTCGAAGGGGGGGG 
                   
               
               
                   
                 CGCTTCTCATCATTTTGCGCAAAACCCCCTTGTGGGAGTATGCCCCGAA 
                   
               
               
                   
                 CTCCTCTGGAACACACAAGCGACACTTGCGCGGGGTCTGCAAAAAACC 
                   
               
               
                   
                 TCCTGTTGGGAAGCCGGCTTCACN 
                   
               
               
                   
               
               
                 NM_002417 
                 TACCGGGCGGAGGTGAGCGCGGCGCCGGCTCCTCCTGCGGCGGACTTT 
                 182 
               
               
                   
                 GGGTGCGACTTGACGAGCGGTGGTTCGACAAGTGGCCTTGCGGGCCGG 
                   
               
               
                   
                 ATCGTCCCAGTGGAAGAGTTGTAAATTTGCTTCTGGCCTTCCCCTACGG 
                   
               
               
                   
                 ATTATACCTGGCCTTCCCCTACGGATTATACTCAACTTACTGTTTAGAAA 
                   
               
               
                   
                 ATGTGGCCCACGAGACGCCTGGTTACTATCAAAAGGAGCGGGGTCGAC 
                   
               
               
                   
                 GGTCCCCACTTTCCCCTGAGCCTCAGCACCTGCTTGTTTGGAAGGGGTA 
                   
               
               
                   
                 TTGAATGTGACATCCGTATCCAGCTTCCTGTTGTGTCAAAACAACATTG 
                   
               
               
                   
                 CAAAATTGAAATCCATGAGCAGGAGGCAATATTACATAATTTCAGTTCC 
                   
               
               
                   
                 ACAAATCCAACACAAGTAAATGGGTCTGTTATTGATGAGCCTGTACGGC 
                   
               
               
                   
                 TAAAACATGGAGATGTAATAACTATTATTGATCGTTCCTTCAGGTATGA 
                   
               
               
                   
                 AAATGAAAGTCTTCAGAATGGAAGGAAGTCAACTGAATTTCCAAGAAA 
                   
               
               
                   
                 AATACGTGAACAGGAGCCAGCACGTCGTGTCTCAAGATCTAGCTTCTCT 
                   
               
               
                   
                 TCTGACCCTGATGAGAAAGCTCAAGATTCCAAGGCCTATTCAAAAATCA 
                   
               
               
                   
                 CTGAAGGAAAAGTTTCAGGAAATCCTCAGGTACATATCAAGAATGTCA 
                   
               
               
                   
                 AAGAAGACAGTACCGCAGATGACTCAAAAGACAGTGTTGCTCAGGGAA 
                   
               
               
                   
                 CAACTAATGTTCATTCCTCAGAACATGCTGGACGTAATGGCAGAAATGC 
                   
               
               
                   
                 AGCTGATCCCATTTCTGGGGATTTTAAAGAAATTTCCAGCGTTAAATTA 
                   
               
               
                   
                 GTGAGCCGTTATGGAGAATTGAAGTCTGTTCCCACTACACAATGTCTTG 
                   
               
               
                   
                 ACAATAGCAAAAAAAATGAATCTCCCTTTTGGAAGCTTTATGAGTCAGT 
                   
               
               
                   
                 GAAGAAAGAGTTGGATGTAAAATCACAAAAAGAAAATGTCCTACAGTA 
                   
               
               
                   
                 TTGTAGAAAATCTGGATTACAAACTGATTACGCAACAGAGAAAGAAAG 
                   
               
               
                   
                 TGCTGATGGTTTACAGGGGGAGACCCAACTGTTGGTCTCGCGTAAGTCA 
                   
               
               
                   
                 AGACCAAAATCTGGTGGGAGCGGCCACGCTGTGGCAGAGCCTGCTTCA 
                   
               
               
                   
                 CCTGAACAAGAGCTTGACCAGAACAAGGGGAAGGGAAGAGACGTGGA 
                   
               
               
                   
                 GTCTGTTCAGACTCCCAGCAAGGCTGTGGGCGCCAGCTTTCCTCTCTAT 
                   
               
               
                   
                 GAGCCGGCTAAAATGAAGACCCCTGTACAATATTCACAGCAACAAAAT 
                   
               
               
                   
                 TCTCCACAAAAACATAAGAACAAAGACCTGTATACTACTGGTAGAAGA 
                   
               
               
                   
                 GAATCTGTGAATCTGGGTAAAAGTGAAGGCTTCAAGGCTGGTGATAAA 
                   
               
               
                   
                 ACTCTTACTCCCAGGAAGCTTTCAACTAGAAATCGAACACCAGCTAAAG 
                   
               
               
                   
                 TTGAAGATGCAGCTGACTCTGCCACTAAGCCAGAAAATCTCTCTTCCAA 
                   
               
               
                   
                 AACCAGAGGAAGTATTCCTACAGATGTGGAAGTTCTGCCTACGGAAAC 
                   
               
               
                   
                 TGAAATTCACAATGAGCCATTTTTAACTCTGTGGCTCACTCAAGTTGAG 
                   
               
               
                   
                 AGGAAGATCCAAAAGGATTCCCTCAGCAAGCCTGAGAAATTGGGCACT 
                   
               
               
                   
                 ACAGCTGGACAGATGTGCTCTGGGTTACCTGGTCTTAGTTCAGTTGATA 
                   
               
               
                   
                 TCAACAACTTTGGTGATTCCATTAATGAGAGTGAGGGAATACCTTTGAA 
                   
               
               
                   
                 AAGAAGGCGTGTGTCCTTTGGTGGGCACCTAAGACCTGAACTATTTGAT 
                   
               
               
                   
                 GAAAACTTGCCTCCTAATACGCCTCTCAAAAGGGGAGAAGCCCCAACC 
                   
               
               
                   
                 AAAAGAAAGTCTCTGGTAATGCACACTCCACCTGTCCTGAAGAAAATC 
                   
               
               
                   
                 ATCAAGGAACAGCCTCAACCATCAGGAAAACAAGAGTCAGGTTCAGAA 
                   
               
               
                   
                 ATCCATGTGGAAGTGAAGGCACAAAGCTTGGTTATAAGCCCTCCAGCTC 
                   
               
               
                   
                 CTAGTCCTAGGAAAACTCCAGTTGCCAGTGATCAACGCCGTAGGTCCTG 
                   
               
               
                   
                 CAAAACAGCCCCTGCTTCCAGCAGCAAATCTCAGACAGAGGTTCCTAA 
                   
               
               
                   
                 GAGAGGAGGGAGAAAGAGTGGCAACCTGCCTTCAAAGAGAGTGTCTAT 
                   
               
               
                   
                 CAGCCGAAGTCAACATGATATTTTACAGATGATATGTTCCAAAAGAAG 
                   
               
               
                   
                 AAGTGGTGCTTCGGAAGCAAATCTGATTGTTGCAAAATCATGGGCAGAT 
                   
               
               
                   
                 GTAGTAAAACTTGGTGCAAAACAAACACAAACTAAAGTCATAAAACAT 
                   
               
               
                   
                 GGTCCTCAAAGGTCAATGAACAAAAGGCAAAGAAGACCTGCTACTCCA 
                   
               
               
                   
                 AAGAAGCCTGTGGGCGAAGTTCACAGTCAATTTAGTACAGGCCACGCA 
                   
               
               
                   
                 AACTCTCCTTGTACCATAATAATAGGGAAAGCTCATACTGAAAAAGTAC 
                   
               
               
                   
                 ATGTGCCTGCTCGACCCTACAGAGTGCTCAACAACTTCATTTCCAACCA 
                   
               
               
                   
                 AAAAATGGACTTTAAGGAAGATCTTTCAGGAATAGCTGAAATGTTCAA 
                   
               
               
                   
                 GACCCCAGTGAAGGAGCAACCGCAGTTGACAAGCACATGTCACATCGC 
                   
               
               
                   
                 TATTTCAAATTCAGAGAATTTGCTTGGAAAACAGTTTCAAGGAACTGAT 
                   
               
               
                   
                 TCAGGAGAAGAACCTCTGCTCCCCACCTCAGAGAGTTTTGGAGGAAAT 
                   
               
               
                   
                 GTGTTCTTCAGTGCACAGAATGCAGCAAAACAGCCATCTGATAAATGCT 
                   
               
               
                   
                 CTGCAAGCCCTCCCTTAAGACGGCAGTGTATTAGAGAAAATGGAAACG 
                   
               
               
                   
                 TAGCAAAAACGCCCAGGAACACCTACAAAATGACTTCTCTGGAGACAA 
                   
               
               
                   
                 AAACTTCAGATACTGAGACAGAGCCTTCAAAAACAGTATCCACTGCAA 
                   
               
               
                   
                 ACAGGTCAGGAAGGTCTACAGAGTTCAGGAATATACAGAAGCTACCTG 
                   
               
               
                   
                 TGGAAAGTAAGAGTGAAGAAACAAATACAGAAATTGTTGAGTGCATCC 
                   
               
               
                   
                 TAAAAAGAGGTCAGAAGGCAACACTACTACAACAAAGGAGAGAAGGA 
                   
               
               
                   
                 GAGATGAAGGAAATAGAAAGACCTTTTGAGACATATAAGGAAAATATT 
                   
               
               
                   
                 GAATTAAAAGAAAACGATGAAAAGATGAAAGCAATGAAGAGATCAAG 
                   
               
               
                   
                 AACTTGGGGGCAGAAATGTGCACCAATGTCTGACCTGACAGACCTCAA 
                   
               
               
                   
                 GAGCTTGCCTGATACAGAACTCATGAAAGACACGGCACGTGGCCAGAA 
                   
               
               
                   
                 TCTCCTCCAAACCCAAGATCATGCCAAGGCACCAAAGAGTGAGAAAGG 
                   
               
               
                   
                 CAAAATCACTAAAATGCCCTGCCAGTCATTACAACCAGAACCAATAAA 
                   
               
               
                   
                 CACCCCAACACACACAAAACAACAGTTGAAGGCATCCCTGGGGAAAGT 
                   
               
               
                   
                 AGGTGTGAAAGAAGAGCTCCTAGCAGTCGGCAAGTTCACACGGACGTC 
                   
               
               
                   
                 AGGGGAGACCACGCACACGCACAGAGAGCCAGCAGGAGATGGCAAGA 
                   
               
               
                   
                 GCATCAGAACGTTTAAGGAGTCTCCAAAGCAGATCCTGGACCCAGCAG 
                   
               
               
                   
                 CCCGTGTAACTGGAATGAAGAAGTGGCCAAGAACGCCTAAGGAAGAGG 
                   
               
               
                   
                 CCCAGTCACTAGAAGACCTGGCTGGCTTCAAAGAGCTCTTCCAGACACC 
                   
               
               
                   
                 AGGTCCCTCTGAGGAATCAATGACTGATGAGAAAACTACCAAAATAGC 
                   
               
               
                   
                 CTGCAAATCTCCACCACCAGAATCAGTGGACACTCCAACAAGCACAAA 
                   
               
               
                   
                 GCAATGGCCTAAGAGAAGTCTCAGGAAAGCAGATGTAGAGGAAGAATT 
                   
               
               
                   
                 CTTAGCACTCAGGAAACTAACACCATCAGCAGGGAAAGCCATGCTTAC 
                   
               
               
                   
                 GCCCAAACCAGCAGGAGGTGATGAGAAAGACATTAAAGCATTTATGGG 
                   
               
               
                   
                 AACTCCAGTGCAGAAACTGGACCTGGCAGGAACTTTACCTGGCAGCAA 
                   
               
               
                   
                 AAGACAGCTACAGACTCCTAAGGAAAAGGCCCAGGCTCTAGAAGACCT 
                   
               
               
                   
                 GGCTGGCTTTAAAGAGCTCTTCCAGACTCCTGGTCACACCGAGGAATTA 
                   
               
               
                   
                 GTGGCTGCTGGTAAAACCACTAAAATACCCTGCGACTCTCCACAGTCAG 
                   
               
               
                   
                 ACCCAGTGGACACCCCAACAAGCACAAAGCAACGACCCAAGAGAAGTA 
                   
               
               
                   
                 TCAGGAAAGCAGATGTAGAGGGAGAACTCTTAGCGTGCAGGAATCTAA 
                   
               
               
                   
                 TGCCATCAGCAGGCAAAGCCATGCACACGCCTAAACCATCAGTAGGTG 
                   
               
               
                   
                 AAGAGAAAGACATCATCATATTTGTGGGAACTCCAGTGCAGAAACTGG 
                   
               
               
                   
                 ACCTGACAGAGAACTTAACCGGCAGCAAGAGACGGCCACAAACTCCTA 
                   
               
               
                   
                 AGGAAGAGGCCCAGGCTCTGGAAGACCTGACTGGCTTTAAAGAGCTCT 
                   
               
               
                   
                 TCCAGACCCCTGGTCATACTGAAGAAGCAGTGGCTGCTGGCAAAACTA 
                   
               
               
                   
                 CTAAAATGCCCTGCGAATCTTCTCCACCAGAATCAGCAGACACCCCAAC 
                   
               
               
                   
                 AAGCACAAGAAGGCAGCCCAAGACACCTTTGGAGAAAAGGGACGTAC 
                   
               
               
                   
                 AGAAGGAGCTCTCAGCCCTGAAGAAGCTCACACAGACATCAGGGGAAA 
                   
               
               
                   
                 CCACACACACAGATAAAGTACCAGGAGGTGAGGATAAAAGCATCAACG 
                   
               
               
                   
                 CGTTTAGGGAAACTGCAAAACAGAAACTGGACCCAGCAGCAAGTGTAA 
                   
               
               
                   
                 CTGGTAGCAAGAGGCACCCAAAAACTAAGGAAAAGGCCCAACCCCTAG 
                   
               
               
                   
                 AAGACCTGGCTGGCTTGAAAGAGCTCTTCCAGACACCAGTATGCACTGA 
                   
               
               
                   
                 CAAGCCCACGACTCACGAGAAAACTACCAAAATAGCCTGCAGATCACA 
                   
               
               
                   
                 ACCAGACCCAGTGGACACACCAACAAGCTCCAAGCCACAGTCCAAGAG 
                   
               
               
                   
                 AAGTCTCAGGAAAGTGGACGTAGAAGAAGAATTCTTCGCACTCAGGAA 
                   
               
               
                   
                 ACGAACACCATCAGCAGGCAAAGCCATGCACACACCCAAACCAGCAGT 
                   
               
               
                   
                 AAGTGGTGAGAAAAACATCTACGCATTTATGGGAACTCCAGTGCAGAA 
                   
               
               
                   
                 ACTGGACCTGACAGAGAACTTAACTGGCAGCAAGAGACGGCTACAAAC 
                   
               
               
                   
                 TCCTAAGGAAAAGGCCCAGGCTCTAGAAGACCTGGCTGGCTTTAAAGA 
                   
               
               
                   
                 GCTCTTCCAGACACGAGGTCACACTGAGGAATCAATGACTAACGATAA 
                   
               
               
                   
                 AACTGCCAAAGTAGCCTGCAAATCTTCACAACCAGACCCAGACAAAAA 
                   
               
               
                   
                 CCCAGCAAGCTCCAAGCGACGGCTCAAGACATCCCTGGGGAAAGTGGG 
                   
               
               
                   
                 CGTGAAAGAAGAGCTCCTAGCAGTTGGCAAGCTCACACAGACATCAGG 
                   
               
               
                   
                 AGAGACTACACACACACACACAGAGCCAACAGGAGATGGTAAGAGCAT 
                   
               
               
                   
                 GAAAGCATTTATGGAGTCTCCAAAGCAGATCTTAGACTCAGCAGCAAG 
                   
               
               
                   
                 TCTAACTGGCAGCAAGAGGCAGCTGAGAACTCCTAAGGGAAAGTCTGA 
                   
               
               
                   
                 AGTCCCTGAAGACCTGGCCGGCTTCATCGAGCTCTTCCAGACACCAAGT 
                   
               
               
                   
                 CACACTAAGGAATCAATGACTAACGAAAAAACTACCAAAGTATCCTAC 
                   
               
               
                   
                 AGAGCTTCACAGCCAGACCTAGTGGACACCCCAACAAGCTCCAAGCCA 
                   
               
               
                   
                 CAGCCCAAGAGAAGTCTCAGGAAAGCAGACACTGAAGAAGAATTTTTA 
                   
               
               
                   
                 GCATTTAGGAAACAAACGCCATCAGCAGGCAAAGCCATGCACACACCC 
                   
               
               
                   
                 AAACCAGCAGTAGGTGAAGAGAAAGACATCAACACGTTTTTGGGAACT 
                   
               
               
                   
                 CCAGTGCAGAAACTGGACCAGCCAGGAAATTTACCTGGCAGCAATAGA 
                   
               
               
                   
                 CGGCTACAAACTCGTAAGGAAAAGGCCCAGGCTCTAGAAGAACTGACT 
                   
               
               
                   
                 GGCTTCAGAGAGCTTTTCCAGACACCATGCACTGATAACCCCACGACTG 
                   
               
               
                   
                 ATGAGAAAACTACCAAAAAAATACTCTGCAAATCTCCGCAATCAGACC 
                   
               
               
                   
                 CAGCGGACACCCCAACAAACACAAAGCAACGGCCCAAGAGAAGCCTCA 
                   
               
               
                   
                 AGAAAGCAGACGTAGAGGAAGAATTTTTAGCATTCAGGAAACTAACAC 
                   
               
               
                   
                 CATCAGCAGGCAAAGCCATGCACACGCCTAAAGCAGCAGTAGGTGAAG 
                   
               
               
                   
                 AGAAAGACATCAACACATTTGTGGGGACTCCAGTGGAGAAACTGGACC 
                   
               
               
                   
                 TGCTAGGAAATTTACCTGGCAGCAAGAGACGGCCACAAACTCCTAAAG 
                   
               
               
                   
                 AAAAGGCCAAGGCTCTAGAAGATCTGGCTGGCTTCAAAGAGCTCTTCC 
                   
               
               
                   
                 AGACACCAGGTCACACTGAGGAATCAATGACCGATGACAAAATCACAG 
                   
               
               
                   
                 AAGTATCCTGCAAATCTCCACAACCAGACCCAGTCAAAACCCCAACAA 
                   
               
               
                   
                 GCTCCAAGCAACGACTCAAGATATCCTTGGGGAAAGTAGGTGTGAAAG 
                   
               
               
                   
                 AAGAGGTCCTACCAGTCGGCAAGCTCACACAGACGTCAGGGAAGACCA 
                   
               
               
                   
                 CACAGACACACAGAGAGACAGCAGGAGATGGAAAGAGCATCAAAGCG 
                   
               
               
                   
                 TTTAAGGAATCTGCAAAGCAGATGCTGGACCCAGCAAACTATGGAACT 
                   
               
               
                   
                 GGGATGGAGAGGTGGCCAAGAACACCTAAGGAAGAGGCCCAATCACTA 
                   
               
               
                   
                 GAAGACCTGGCCGGCTTCAAAGAGCTCTTCCAGACACCAGACCACACT 
                   
               
               
                   
                 GAGGAATCAACAACTGATGACAAAACTACCAAAATAGCCTGCAAATCT 
                   
               
               
                   
                 CCACCACCAGAATCAATGGACACTCCAACAAGCACAAGGAGGCGGCCC 
                   
               
               
                   
                 AAAACACCTTTGGGGAAAAGGGATATAGTGGAAGAGCTCTCAGCCCTG 
                   
               
               
                   
                 AAGCAGCTCACACAGACCACACACACAGACAAAGTACCAGGAGATGAG 
                   
               
               
                   
                 GATAAAGGCATCAACGTGTTCAGGGAAACTGCAAAACAGAAACTGGAC 
                   
               
               
                   
                 CCAGCAGCAAGTGTAACTGGTAGCAAGAGGCAGCCAAGAACTCCTAAG 
                   
               
               
                   
                 GGAAAAGCCCAACCCCTAGAAGACTTGGCTGGCTTGAAAGAGCTCTTC 
                   
               
               
                   
                 CAGACACCAATATGCACTGACAAGCCCACGACTCATGAGAAAACTACC 
                   
               
               
                   
                 AAAATAGCCTGCAGATCTCCACAACCAGACCCAGTGGGTACCCCAACA 
                   
               
               
                   
                 ATCTTCAAGCCACAGTCCAAGAGAAGTCTCAGGAAAGCAGACGTAGAG 
                   
               
               
                   
                 GAAGAATCCTTAGCACTCAGGAAACGAACACCATCAGTAGGGAAAGCT 
                   
               
               
                   
                 ATGGACACACCCAAACCAGCAGGAGGTGATGAGAAAGACATGAAAGC 
                   
               
               
                   
                 ATTTATGGGAACTCCAGTGCAGAAATTGGACCTGCCAGGAAATTTACCT 
                   
               
               
                   
                 GGCAGCAAAAGATGGCCACAAACTCCTAAGGAAAAGGCCCAGGCTCTA 
                   
               
               
                   
                 GAAGACCTGGCTGGCTTCAAAGAGCTCTTCCAGACACCAGGCACTGAC 
                   
               
               
                   
                 AAGCCCACGACTGATGAGAAAACTACCAAAATAGCCTGCAAATCTCCA 
                   
               
               
                   
                 CAACCAGACCCAGTGGACACCCCAGCAAGCACAAAGCAACGGCCCAAG 
                   
               
               
                   
                 AGAAACCTCAGGAAAGCAGACGTAGAGGAAGAATTTTTAGCACTCAGG 
                   
               
               
                   
                 AAACGAACACCATCAGCAGGCAAAGCCATGGACACACCAAAACCAGCA 
                   
               
               
                   
                 GTAAGTGATGAGAAAAATATCAACACATTTGTGGAAACTCCAGTGCAG 
                   
               
               
                   
                 AAACTGGACCTGCTAGGAAATTTACCTGGCAGCAAGAGACAGCCACAG 
                   
               
               
                   
                 ACTCCTAAGGAAAAGGCTGAGGCTCTAGAGGACCTGGTTGGCTTCAAA 
                   
               
               
                   
                 GAACTCTTCCAGACACCAGGTCACACTGAGGAATCAATGACTGATGAC 
                   
               
               
                   
                 AAAATCACAGAAGTATCCTGTAAATCTCCACAGCCAGAGTCATTCAAA 
                   
               
               
                   
                 ACCTCAAGAAGCTCCAAGCAAAGGCTCAAGATACCCCTGGTGAAAGTG 
                   
               
               
                   
                 GACATGAAAGAAGAGCCCCTAGCAGTCAGCAAGCTCACACGGACATCA 
                   
               
               
                   
                 GGGGAGACTACGCAAACACACACAGAGCCAACAGGAGATAGTAAGAG 
                   
               
               
                   
                 CATCAAAGCGTTTAAGGAGTCTCCAAAGCAGATCCTGGACCCAGCAGC 
                   
               
               
                   
                 AAGTGTAACTGGTAGCAGGAGGCAGCTGAGAACTCGTAAGGAAAAGGC 
                   
               
               
                   
                 CCGTGCTCTAGAAGACCTGGTTGACTTCAAAGAGCTCTTCTCAGCACCA 
                   
               
               
                   
                 GGTCACACTGAAGAGTCAATGACTATTGACAAAAACACAAAAATTCCC 
                   
               
               
                   
                 TGCAAATCTCCCCCACCAGAACTAACAGACACTGCCACGAGCACAAAG 
                   
               
               
                   
                 AGATGCCCCAAGACACGTCCCAGGAAAGAAGTAAAAGAGGAGCTCTCA 
                   
               
               
                   
                 GCAGTTGAGAGGCTCACGCAAACATCAGGGCAAAGCACACACACACAC 
                   
               
               
                   
                 AAAGAACCAGCAAGCGGTGATGAGGGCATCAAAGTATTGAAGCAACGT 
                   
               
               
                   
                 GCAAAGAAGAAACCAAACCCAGTAGAAGAGGAACCCAGCAGGAGAAG 
                   
               
               
                   
                 GCCAAGAGCACCTAAGGAAAAGGCCCAACCCCTGGAAGACCTGGCCGG 
                   
               
               
                   
                 CTTCACAGAGCTCTCTGAAACATCAGGTCACACTCAGGAATCACTGACT 
                   
               
               
                   
                 GCTGGCAAAGCCACTAAAATACCCTGCGAATCTCCCCCACTAGAAGTG 
                   
               
               
                   
                 GTAGACACCACAGCAAGCACAAAGAGGCATCTCAGGACACGTGTGCAG 
                   
               
               
                   
                 AAGGTACAAGTAAAAGAAGAGCCTTCAGCAGTCAAGTTCACACAAACA 
                   
               
               
                   
                 TCAGGGGAAACCACGGATGCAGACAAAGAACCAGCAGGTGAAGATAA 
                   
               
               
                   
                 AGGCATCAAAGCATTGAAGGAATCTGCAAAACAGACACCGGCTCCAGC 
                   
               
               
                   
                 AGCAAGTGTAACTGGCAGCAGGAGACGGCCAAGAGCACCCAGGGAAA 
                   
               
               
                   
                 GTGCCCAAGCCATAGAAGACCTAGCTGGCTTCAAAGACCCAGCAGCAG 
                   
               
               
                   
                 GTCACACTGAAGAATCAATGACTGATGACAAAACCACTAAAATACCCT 
                   
               
               
                   
                 GCAAATCATCACCAGAACTAGAAGACACCGCAACAAGCTCAAAGAGAC 
                   
               
               
                   
                 GGCCCAGGACACGTGCCCAGAAAGTAGAAGTGAAGGAGGAGCTGTTAG 
                   
               
               
                   
                 CAGTTGGCAAGCTCACACAAACCTCAGGGGAGACCACGCACACCGACA 
                   
               
               
                   
                 AAGAGCCGGTAGGTGAGGGCAAAGGCACGAAAGCATTTAAGCAACCTG 
                   
               
               
                   
                 CAAAGCGGAAGCTGGACGCAGAAGATGTAATTGGCAGCAGGAGACAG 
                   
               
               
                   
                 CCAAGAGCACCTAAGGAAAAGGCCCAACCCCTGGAAGATCTGGCCAGC 
                   
               
               
                   
                 TTCCAAGAGCTCTCTCAAACACCAGGCCACACTGAGGAACTGGCAAAT 
                   
               
               
                   
                 GGTGCTGCTGATAGCTTTACAAGCGCTCCAAAGCAAACACCTGACAGTG 
                   
               
               
                   
                 GAAAACCTCTAAAAATATCCAGAAGAGTTCTTCGGGCCCCTAAAGTAG 
                   
               
               
                   
                 AACCCGTGGGAGACGTGGTAAGCACCAGAGACCCTGTAAAATCACAAA 
                   
               
               
                   
                 GCAAAAGCAACACTTCCCTGCCCCCACTGCCCTTCAAGAGGGGAGGTG 
                   
               
               
                   
                 GCAAAGATGGAAGCGTCACGGGAACCAAGAGGCTGCGCTGCATGCCAG 
                   
               
               
                   
                 CACCAGAGGAAATTGTGGAGGAGCTGCCAGCCAGCAAGAAGCAGAGG 
                   
               
               
                   
                 GTTGCTCCCAGGGCAAGAGGCAAATCATCCGAACCCGTGGTCATCATG 
                   
               
               
                   
                 AAGAGAAGTTTGAGGACTTCTGCAAAAAGAATTGAACCTGCGGAAGAG 
                   
               
               
                   
                 CTGAACAGCAACGACATGAAAACCAACAAAGAGGAACACAAATTACA 
                   
               
               
                   
                 AGACTCGGTCCCTGAAAATAAGGGAATATCCCTGCGCTCCAGACGCCA 
                   
               
               
                   
                 AAATAAGACTGAGGCAGAACAGCAAATAACTGAGGTCTTTGTATTAGC 
                   
               
               
                   
                 AGAAAGAATAGAAATAAACAGAAATGAAAAGAAGCCCATGAAGACCT 
                   
               
               
                   
                 CCCCAGAGATGGACATTCAGAATCCAGATGATGGAGCCCGGAAACCCA 
                   
               
               
                   
                 TACCTAGAGACAAAGTCACTGAGAACAAAAGGTGCTTGAGGTCTGCTA 
                   
               
               
                   
                 GACAGAATGAGAGCTCCCAGCCTAAGGTGGCAGAGGAGAGCGGAGGG 
                   
               
               
                   
                 CAGAAGAGTGCGAAGGTTCTCATGCAGAATCAGAAAGGGAAAGGAGA 
                   
               
               
                   
                 AGCAGGAAATTCAGACTCCATGTGCCTGAGATCAAGAAAGACAAAAAG 
                   
               
               
                   
                 CCAGCCTGCAGCAAGCACTTTGGAGAGCAAATCTGTGCAGAGAGTAAC 
                   
               
               
                   
                 GCGGAGTGTCAAGAGGTGTGCAGAAAATCCAAAGAAGGCTGAGGACA 
                   
               
               
                   
                 ATGTGTGTGTCAAGAAAATAAGAACCAGAAGTCATAGGGACAGTGAAG 
                   
               
               
                   
                 ATATTTGACAGAAAAATCGAACTGGGAAAAATATAATAAAGTTAGTTTT 
                   
               
               
                   
                 GTGATAAGTTCTAGTGCAGTTTTTGTCATAAATTACAAGTGAATTCTGT 
                   
               
               
                   
                 AAGTAAGGCTGTCAGTCTGCTTAAGGGAAGAAAACTTTGGATTTGCTGG 
                   
               
               
                   
                 GTCTGAATCGGCTTCATAAACTCCACTGGGAGCACTGCTGGGCTCCTGG 
                   
               
               
                   
                 ACTGAGAATAGTTGAACACCGGGGGCTTTGTGAAGGAGTCTGGGCCAA 
                   
               
               
                   
                 GGTTTGCCCTCAGCTTTGCAGAATGAAGCCTTGAGGTCTGTCACCACCC 
                   
               
               
                   
                 ACAGCCACCCTACAGCAGCCTTAACTGTGACACTTGCCACACTGTGTCG 
                   
               
               
                   
                 TCGTTTGTTTGCCTATGTCCTCCAGGGCACGGTGGCAGGAACAACTATC 
                   
               
               
                   
                 CTCGTCTGTCCCAACACTGAGCAGGCACTCGGTAAACACGAATGAATG 
                   
               
               
                   
                 GATGAGCGCACGGATGAATGGAGCTTACAAGATCTGTCTTTCCAATGGC 
                   
               
               
                   
                 CGGGGGCATTTGGTCCCCAAATTAAGGCTATTGGACATCTGCACAGGAC 
                   
               
               
                   
                 AGTCCTATTTTTGATGTCCTTTCCTTTCTGAAAATAAAGTTTTGTGCTTT 
                   
               
               
                   
                 GGAGAATGACTCGTGAGCACATCTTTAGGGACCAAGAGTGACTTTCTGT 
                   
               
               
                   
                 AAGGAGTGACTCGTGGCTTGCCTTGGTCTCTTGGGAATACTTTTCTAACT 
                   
               
               
                   
                 AGGGTTGCTCTCACCTGAGACATTCTCCACCCGCGGAATCTCAGGGTCC 
                   
               
               
                   
                 CAGGCTGTGGGCCATCACGACCTCAAACTGGCTCCTAATCTCCAGCTTT 
                   
               
               
                   
                 CCTGTCATTGAAAGCTTCGGAAGTTTACTGGCTCTGCTCCCGCCTGTTTT 
                   
               
               
                   
                 CTTTCTGACTCTATCTGGCAGCCCGATGCCACCCAGTACAGGAAGTGAC 
                   
               
               
                   
                 ACCAGTACTCTGTAAAGCATCATCATCCTTGGAGAGACTGAGCACTCAG 
                   
               
               
                   
                 CACCTTCAGCCACGATTTCAGGATCGCTTCCTTGTGAGCCGCTGCCTCC 
                   
               
               
                   
                 GAAATCTCCTTTGAAGCCCAGACATCTTTCTCCAGCTTCAGACTTGTAG 
                   
               
               
                   
                 ATATAACTCGTTCATCTTCATTTACTTTCCACTTTGCCCCCTGTCCTCTCT 
                   
               
               
                   
                 GTGTTCCCCAAATCAGAGAATAGCCCGCCATCCCCCAGGTCACCTGTCT 
                   
               
               
                   
                 GGATTCCTCCCCATTCACCCACCTTGCCAGGTGCAGGTGAGGATGGTGC 
                   
               
               
                   
                 ACCAGACAGGGTAGCTGTCCCCCAAAATGTGCCCTGTGCGGGCAGTGC 
                   
               
               
                   
                 CCTGTCTCCACGTTTGTTTCCCCAGTGTCTGGCGGGGAGCCAGGTGACA 
                   
               
               
                   
                 TCATAAATACTTGCTGAATGAATGCAGAAATCAGCGGTACTGACTTGTA 
                   
               
               
                   
                 CTATATTGGCTGCCATGATAGGGTTCTCACAGCGTCATCCATGATCGTA 
                   
               
               
                   
                 AGGGAGAATGACATTCTGCTTGAGGGAGGGAATAGAAAGGGGCAGGG 
                   
               
               
                   
                 AGGGGACATCTGAGGGCTTCACAGGGCTGCAAAGGGTACAGGGATTGC 
                   
               
               
                   
                 ACCAGGGCAGAACAGGGGAGGGTGTTCAAGGAAGAGTGGCTCTTAGCA 
                   
               
               
                   
                 GAGGCACTTTGGAAGGTGTGAGGCATAAATGCTTCCTTCTACGTAGGCC 
                   
               
               
                   
                 AACCTCAAAACTTTCAGTAGGAATGTTGCTATGATCAAGTTGTTCTAAC 
                   
               
               
                   
                 ACTTTAGACTTAGTAGTAATTATGAACCTCACATAGAAAAATTTCATCC 
                   
               
               
                   
                 AGCCATATGCCTGTGGAGTGGAATATTCTGTTTAGTAGAAAAATCCTTT 
                   
               
               
                   
                 AGAGTTCAGCTCTAACCAGAAATCTTGCTGAAGTATGTCAGCACCTTTT 
                   
               
               
                   
                 CTCACCCTGGTAAGTACAGTATTTCAAGAGCACGCTAAGGGTGGTTTTC 
                   
               
               
                   
                 ATTTTACAGGGCTGTTGATGATGGGTTAAAAATGTTCATTTAAGGGCTA 
                   
               
               
                   
                 CCCCCGTGTTTAATAGATGAACACCACTTCTACACAACCCTCCTTGGTA 
                   
               
               
                   
                 CTGGGGGAGGGAGAGATCTGACAAATACTGCCCATTCCCCTAGGCTGA 
                   
               
               
                   
                 CTGGATTTGAGAACAAATACCCACCCATTTCCACCATGGTATGGTAACT 
                   
               
               
                   
                 TCTCTGAGCTTCAGTTTCCAAGTGAATTTCCATGTAATAGGACATTCCCA 
                   
               
               
                   
                 TTAAATACAAGCTGTTTTTACTTTTTCGCCTCCCAGGGCCTGTGGGATCT 
                   
               
               
                   
                 GGTCCCCCAGCCTCTCTTGGGCTTTCTTACACTAACTCTGTACCTACCAT 
                   
               
               
                   
                 CTCCTGCCTCCCTTAGGCAGGCACCTCCAACCACCACACACTCCCTGCT 
                   
               
               
                   
                 GTTTTCCCTGCCTGGAACTTTCCCTCCTGCCCCACCAAGATCATTTCATC 
                   
               
               
                   
                 CAGTCCTGAGCTCAGCTTAAGGGAGGCTTCTTGCCTGTGGGTTCCCTCA 
                   
               
               
                   
                 CCCCCATGCCTGTCCTCCAGGCTGGGGCAGGTTCTTAGTTTGCCTGGAA 
                   
               
               
                   
                 TTGTTCTGTACCTCTTTGTAGCACGTAGTGTTGTGGAAACTAAGCCACTA 
                   
               
               
                   
                 ATTGAGTTTCTGGCTCCCCTCCTGGGGTTGTAAGTTTTGTTCATTCATGA 
                   
               
               
                   
                 GGGCCGACTGCATTTCCTGGTTACTCTATCCCAGTGACCAGCCACAGGA 
                   
               
               
                   
                 GATGTCCAATAAAGTATGTGATGAAATGGTCTTAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_024101 
                 GCGCCGGGACGTGGCCAGTTGCCCGCCTGCCCCGGAGAGCCAGGCGCT 
                 183 
               
               
                   
                 AACCAGCCGCTCTGCGCCCCGCGCCCTGCTTGCCCCCATTATCCAGCCT 
                   
               
               
                   
                 TGCCCCGGCGCCCTGACCTGACGCCCTGGCCTGACGCCCTGCTTCGTCG 
                   
               
               
                   
                 CCTCCTTTCTCTCCCAGGTGCTGGACCAGGGACTGAGCGTCCCCCGGAG 
                   
               
               
                   
                 AGGGTCCGGTGTGACCCCGACAAGAAGCAGAAATGGGGAAGAAACTG 
                   
               
               
                   
                 GATCTTTCCAAGCTCACTGATGAAGAGGCCCAGCATGTCTTGGAAGTTG 
                   
               
               
                   
                 TTCAACGAGATTTTGACCTCCGAAGGAAAGAAGAGGAACGGCTAGAGG 
                   
               
               
                   
                 CGTTGAAGGGCAAGATTAAGAAGGAAAGCTCCAAGAGGGAGCTGCTTT 
                   
               
               
                   
                 CCGACACTGCCCATCTGAACGAGACCCACTGCGCCCGCTGCCTGCAGCC 
                   
               
               
                   
                 CTACCAGCTGCTTGTGAATAGCAAAAGGCAGTGCCTGGAATGTGGCCTC 
                   
               
               
                   
                 TTCACCTGCAAAAGCTGTGGCCGCGTCCACCCGGAGGAGCAGGGCTGG 
                   
               
               
                   
                 ATCTGTGACCCCTGCCATCTGGCCAGAGTCGTGAAGATCGGCTCACTGG 
                   
               
               
                   
                 AGTGGTACTATGAGCATGTGAAAGCCCGCTTCAAGAGGTTCGGAAGTG 
                   
               
               
                   
                 CCAAGGTCATCCGGTCCCTCCACGGGCGGCTGCAGGGTGGAGCTGGGC 
                   
               
               
                   
                 CTGAACTGATATCTGAAGAGAGAAGTGGAGACAGCGACCAGACAGATG 
                   
               
               
                   
                 AGGATGGAGAACCTGGCTCAGAGGCCCAGGCCCAGGCCCAGCCCTTTG 
                   
               
               
                   
                 GCAGCAAAAAAAAGCGCCTCCTCTCCGTCCACGACTTCGACTTCGAGGG 
                   
               
               
                   
                 AGACTCAGATGACTCCACTCAGCCTCAAGGTCACTCCCTGCACCTGTCC 
                   
               
               
                   
                 TCAGTCCCTGAGGCCAGGGACAGCCCACAGTCCCTCACAGATGAGTCCT 
                   
               
               
                   
                 GCTCAGAGAAGGCAGCCCCTCACAAGGCTGAGGGCCTGGAGGAGGCTG 
                   
               
               
                   
                 ATACTGGGGCCTCTGGGTGCCACTCCCATCCGGAAGAGCAGCCGACCA 
                   
               
               
                   
                 GCATCTCACCTTCCAGACACGGCGCCCTGGCTGAGCTCTGCCCGCCTGG 
                   
               
               
                   
                 AGGCTCCCACAGGATGGCCCTGGGGACTGCTGCTGCACTCGGGTCGAAT 
                   
               
               
                   
                 GTCATCAGGAATGAGCAGCTGCCCCTGCAGTACTTGGCCGATGTGGACA 
                   
               
               
                   
                 CCTCTGATGAGGAAAGCATCCGGGCTCACGTGATGGCCTCCCACCATTC 
                   
               
               
                   
                 CAAGCGGAGAGGCCGGGCGTCTTCTGAGAGTCAGATCTTTGAGCTGAA 
                   
               
               
                   
                 TAAGCATATTTCAGCTGTGGAATGCCTGCTGACCTACCTGGAGAACACA 
                   
               
               
                   
                 GTTGTGCCTCCCTTGGCCAAGGGTCTAGGTGCTGGAGTGCGCACGGAGG 
                   
               
               
                   
                 CCGATGTAGAGGAGGAGGCCCTGAGGAGGAAGCTGGAGGAGCTGACC 
                   
               
               
                   
                 AGCAACGTCAGTGACCAGGAGACCTCGTCCGAGGAGGAGGAAGCCAAG 
                   
               
               
                   
                 GACGAAAAGGCAGAGCCCAACAGGGACAAATCAGTTGGGCCTCTCCCC 
                   
               
               
                   
                 CAGGCGGACCCGGAGGTGGGCACGGCTGCCCATCAAACCAACAGACAG 
                   
               
               
                   
                 GAAAAAAGCCCCCAGGACCCTGGGGACCCCGTCCAGTACAACAGGACC 
                   
               
               
                   
                 ACAGATGAGGAGCTGTCAGAGCTGGAGGACAGAGTGGCAGTGACGGCC 
                   
               
               
                   
                 TCAGAAGTCCAGCAGGCAGAGAGCGAGGTTTCAGACATTGAATCCAGG 
                   
               
               
                   
                 ATTGCAGCCCTGAGGGCCGCAGGGCTCACGGTGAAGCCCTCGGGAAAG 
                   
               
               
                   
                 CCCCGGAGGAAGTCAAACCTCCCGATATTTCTCCCTCGAGTGGCTGGGA 
                   
               
               
                   
                 AACTTGGCAAGAGACCAGAGGACCCAAATGCAGACCCTTCAAGTGAGG 
                   
               
               
                   
                 CCAAGGCAATGGCTGTGCCCTATCTTCTGAGAAGAAAGTTCAGTAATTC 
                   
               
               
                   
                 CCTGAAAAGTCAAGGTAAAGATGATGATTCTTTTGATCGGAAATCAGTG 
                   
               
               
                   
                 TACCGAGGCTCGCTGACACAGAGAAACCCCAACGCGAGGAAAGGAATG 
                   
               
               
                   
                 GCCAGCCACACCTTCGCGAAACCTGTGGTGGCCCACCAGTCCTAACGGG 
                   
               
               
                   
                 ACAGGACAGAGAGACAGAGCAGCCCTGCACTGTTTTCCCTCCACCACA 
                   
               
               
                   
                 GCCATCCTGTCCCTCATTGGCTCTGTGCTTTCCACTATACACAGTCACCG 
                   
               
               
                   
                 TCCCAATGAGAAACAAGAAGGAGCACCCTCCACATGGACTCCCACCTG 
                   
               
               
                   
                 CAAGTGGACAGCGACATTCAGTCCTGCACTGCTCACCTGGGTTTACTGA 
                   
               
               
                   
                 TGACTCCTGGCTGCCCCACCATCCTCTCTGATCTGTGAGAAACAGCTAA 
                   
               
               
                   
                 GCTGCTGTGACTTCCCTTTAGGACAATGTTGTGTAAATCTTTGAAGGAC 
                   
               
               
                   
                 ACACCGAAGACCTTTATACTGTGATCTTTTACCCCTTTCACTCTTGGCTT 
                   
               
               
                   
                 TCTTATGTTGCTTTCATGAATGGAATGGAAAAAAGATGACTCAGTTAAG 
                   
               
               
                   
                 GCACCAGCCATATGTGTATTCTTGATGGTCTATATCGGGGTGTGAGCAG 
                   
               
               
                   
                 ATGTTTGCGTATTTCTTGTGGGTGTGACTGGATATTAGACATCCGGACA 
                   
               
               
                   
                 AGTGACTGAACTAATGATCTGCTGAATAATGAAGGAGGAATAGACACC 
                   
               
               
                   
                 CCAGTCCCCACCCTACGTGCACCCGCTCTGCAAGTTCCCATGTGATCTG 
                   
               
               
                   
                 TAGACCAGGGGAAATTACACTGCGGTCAAGGGCAGAGCCTGCACATGA 
                   
               
               
                   
                 CAGCAAGTGAGCATTTGATAGATGCTCAGATGCTAGTGCAGAGAGCCT 
                   
               
               
                   
                 GCTGGGAGACGAAGAGACAGCAGGCAGAGCTCCAGATGGGCAAGGAA 
                   
               
               
                   
                 GAGGCTTGGTTCTAGCCTGGCTCTGCCCCTCACTGCAGTGGATCCAGTG 
                   
               
               
                   
                 GGGCAGAGGACAGAGGGTCACAACCAATGAGGGATGTCTGCCAAGGAT 
                   
               
               
                   
                 GGGGGTGCAGAGGCCACAGGAGTCAGCTTGCCACTCGCCCATTGGTTA 
                   
               
               
                   
                 CATAGATGATCTCTCAGACAGGCTGGGACTCAGAGTTATTTCCTAGTAT 
                   
               
               
                   
                 CGGTGTGCCCCATCCAGTTTTAAGTGGAGCCCTCCAAGACTCTCCAGAG 
                   
               
               
                   
                 CTGCCTTTGAACATCCTAACAGTAATCACATCTCACCCTCCCTGAGGTTC 
                   
               
               
                   
                 ACTTTAGACAGGACCCAATGGCTGCACTGCCTTTGTCAGAGGGGGTGCT 
                   
               
               
                   
                 GAGAGGAGTGGCTTCTTTTAGAATCAAACAGTAGAGACAAGAGTCAAG 
                   
               
               
                   
                 CCTTGTGTCTTCAAGCATTGACCAAGTTAAGTGTTTCCTTCCCTCTCTCA 
                   
               
               
                   
                 ATAAGACACTTCCAGGAGCTTTCCAATCTCTCACTTAAAACTAAGGTTT 
                   
               
               
                   
                 GAATCTCAAAGTGTTGCTGGGAGGCTGATACTCCTGCAACTTCAGGAGA 
                   
               
               
                   
                 CCTGTGAGCACACATTAGCAGCTGTTTCTCTGACTCCTTGTGGCATCAG 
                   
               
               
                   
                 ATAAAAACGTGGGAGTTTTTCCATATAATTCCCAGCCTTACTTATAAAT 
                   
               
               
                   
                 TCTATTCTTTGAAAAAATTATTCAGGCTAGGTAAGGTGGCTCATACCTA 
                   
               
               
                   
                 TAATCCCAGCCCTTTGAGAGGCCAAGGTGGGAGAATTGCTTGAGGCCA 
                   
               
               
                   
                 GGAGTTTGAGACCTCCTGGGCAACATAGTGAGATCCCATCTCTACAAAA 
                   
               
               
                   
                 AACAAAACAAAAAAATTACCCAAGCATGATGGTATATGCCTGTAGTCG 
                   
               
               
                   
                 TACCTACTTACTTAGGAGGCTGAGGCAGGAGGATCACTTGAGCCCTGGA 
                   
               
               
                   
                 GGTTGGGGCTGCAGTGAGCCATGATCGCATCACTATACTCGAGCCTGGG 
                   
               
               
                   
                 CAACAGAGTGAGACCTTGTCTCTTAAAAAAATTAATAATAAATAAATG 
                   
               
               
                   
                 AAAATAATTCTTCAGAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_005940 
                 AAGCCCAGCAGCCCCGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAG 
                 184 
               
               
                   
                 CGCGGCCGCGCGCGCCCTCCTGCCCCCGATGCTGCTGCTGCTGCTCCAG 
                   
               
               
                   
                 CCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGACGCCCACCACCTCC 
                   
               
               
                   
                 ATGCCGAGAGGAGGGGGCCACAGCCCTGGCATGCAGCCCTGCCCAGTA 
                   
               
               
                   
                 GCCCGGCACCTGCCCCTGCCACGCAGGAAGCCCCCCGGCCTGCCAGCA 
                   
               
               
                   
                 GCCTCAGGCCTCCCCGCTGTGGCGTGCCCGACCCATCTGATGGGCTGAG 
                   
               
               
                   
                 TGCCCGCAACCGACAGAAGAGGTTCGTGCTTTCTGGCGGGCGCTGGGA 
                   
               
               
                   
                 GAAGACGGACCTCACCTACAGGATCCTTCGGTTCCCATGGCAGTTGGTG 
                   
               
               
                   
                 CAGGAGCAGGTGCGGCAGACGATGGCAGAGGCCCTAAAGGTATGGAGC 
                   
               
               
                   
                 GATGTGACGCCACTCACCTTTACTGAGGTGCACGAGGGCCGTGCTGACA 
                   
               
               
                   
                 TCATGATCGACTTCGCCAGGTACTGGCATGGGGACGACCTGCCGTTTGA 
                   
               
               
                   
                 TGGGCCTGGGGGCATCCTGGCCCATGCCTTCTTCCCCAAGACTCACCGA 
                   
               
               
                   
                 GAAGGGGATGTCCACTTCGACTATGATGAGACCTGGACTATCGGGGAT 
                   
               
               
                   
                 GACCAGGGCACAGACCTGCTGCAGGTGGCAGCCCATGAATTTGGCCAC 
                   
               
               
                   
                 GTGCTGGGGCTGCAGCACACAACAGCAGCCAAGGCCCTGATGTCCGCC 
                   
               
               
                   
                 TTCTACACCTTTCGCTACCCACTGAGTCTCAGCCCAGATGACTGCAGGG 
                   
               
               
                   
                 GCGTTCAACACCTATATGGCCAGCCCTGGCCCACTGTCACCTCCAGGAC 
                   
               
               
                   
                 CCCAGCCCTGGGCCCCCAGGCTGGGATAGACACCAATGAGATTGCACC 
                   
               
               
                   
                 GCTGGAGCCAGACGCCCCGCCAGATGCCTGTGAGGCCTCCTTTGACGCG 
                   
               
               
                   
                 GTCTCCACCATCCGAGGCGAGCTCTTTTTCTTCAAAGCGGGCTTTGTGTG 
                   
               
               
                   
                 GCGCCTCCGTGGGGGCCAGCTGCAGCCCGGCTACCCAGCATTGGCCTCT 
                   
               
               
                   
                 CGCCACTGGCAGGGACTGCCCAGCCCTGTGGACGCTGCCTTCGAGGATG 
                   
               
               
                   
                 CCCAGGGCCACATTTGGTTCTTCCAAGGTGCTCAGTACTGGGTGTACGA 
                   
               
               
                   
                 CGGTGAAAAGCCAGTCCTGGGCCCCGCACCCCTCACCGAGCTGGGCCT 
                   
               
               
                   
                 GGTGAGGTTCCCGGTCCATGCTGCCTTGGTCTGGGGTCCCGAGAAGAAC 
                   
               
               
                   
                 AAGATCTACTTCTTCCGAGGCAGGGACTACTGGCGTTTCCACCCCAGCA 
                   
               
               
                   
                 CCCGGCGTGTAGACAGTCCCGTGCCCCGCAGGGCCACTGACTGGAGAG 
                   
               
               
                   
                 GGGTGCCCTCTGAGATCGACGCTGCCTTCCAGGATGCTGATGGCTATGC 
                   
               
               
                   
                 CTACTTCCTGCGCGGCCGCCTCTACTGGAAGTTTGACCCTGTGAAGGTG 
                   
               
               
                   
                 AAGGCTCTGGAAGGCTTCCCCCGTCTCGTGGGTCCTGACTTCTTTGGCT 
                   
               
               
                   
                 GTGCCGAGCCTGCCAACACTTTCCTCTGACCATGGCTTGGATGCCCTCA 
                   
               
               
                   
                 GGGGTGCTGACCCCTGCCAGGCCACGAATATCAGGCTAGAGACCCATG 
                   
               
               
                   
                 GCCATCTTTGTGGCTGTGGGCACCAGGCATGGGACTGAGCCCATGTCTC 
                   
               
               
                   
                 CTCAGGGGGATGGGGTGGGGTACAACCACCATGACAACTGCCGGGAGG 
                   
               
               
                   
                 GCCACGCAGGTCGTGGTCACCTGCCAGCGACTGTCTCAGACTGGGCAG 
                   
               
               
                   
                 GGAGGCTTTGGCATGACTTAAGAGGAAGGGCAGTCTTGGGCCCGCTAT 
                   
               
               
                   
                 GCAGGTCCTGGCAAACCTGGCTGCCCTGTCTCCATCCCTGTCCCTCAGG 
                   
               
               
                   
                 GTAGCACCATGGCAGGACTGGGGGAACTGGAGTGTCCTTGCTGTATCCC 
                   
               
               
                   
                 TGTTGTGAGGTTCCTTCCAGGGGCTGGCACTGAAGCAAGGGTGCTGGGG 
                   
               
               
                   
                 CCCCATGGCCTTCAGCCCTGGCTGAGCAACTGGGCTGTAGGGCAGGGCC 
                   
               
               
                   
                 ACTTCCTGAGGTCAGGTCTTGGTAGGTGCCTGCATCTGTCTGCCTTCTGG 
                   
               
               
                   
                 CTGACAATCCTGGAAATCTGTTCTCCAGAATCCAGGCCAAAAAGTTCAC 
                   
               
               
                   
                 AGTCAAATGGGGAGGGGTATTCTTCATGCAGGAGACCCCAGGCCCTGG 
                   
               
               
                   
                 AGGCTGCAACATACCTCAATCCTGTCCCAGGCCGGATCCTCCTGAAGCC 
                   
               
               
                   
                 CTTTTCGCAGCACTGCTATCCTCCAAAGCCATTGTAAATGTGTGTACAG 
                   
               
               
                   
                 TGTGTATAAACCTTCTTCTTCTTTTTTTTTTTTTAAACTGAGGATTGTC 
                   
               
               
                   
               
               
                 BX647151 
                 TAGCAGCACACAAGGGTTCGTGTTTGTGGAACCAGGTAGCTTCCTTCAG 
                 185 
               
               
                   
                 AGCTGACATTTGCCCACAGCCAGCCTGGCCCAGCCCCATACCACCAGCC 
                   
               
               
                   
                 CTGGCGCTCTGGGGCGTGAGGTGCCTTTTCTGCCCCCCTGCTCTAGGGC 
                   
               
               
                   
                 AGGTGGAAATCACCCATGGTGGGTCTACATCTGATAGAAGCATCTTATA 
                   
               
               
                   
                 GTTCTGCTTCTGGACCAGACCATCCTGGGTTTTTCTCTGTTCTGCTGAAG 
                   
               
               
                   
                 GGTTCCCTCCACGTGTCCATCACCTCGGTGAACTCTTGGGAGACCTGGG 
                   
               
               
                   
                 AAGATGCTGGCCTCACCTCTCGCCTCTCCTTTCCCTCATTGTGCTGCCAC 
                   
               
               
                   
                 CATCCTTCTCACACAGGCTCTCCAGGGAGAGCTGGGCAGGATGGGATCT 
                   
               
               
                   
                 TCCTGGGTTCCCACCTTGCTCCGTGCCCCCTCTCACTGTTCCTGAAGTGT 
                   
               
               
                   
                 GGCCACGGACTGCCTTGTTTTCTGGAAAGTCCCAAGTCTGGACCATGAC 
                   
               
               
                   
                 TGAGCAGCATTCTCGGCTATCTGCCACCTGTCTGGGGCTCCTGGCCCCT 
                   
               
               
                   
                 CTTAGACTCCCCTCTCCCTTCTGTTTCCCCCGAGCCCCTGACTTGGACCT 
                   
               
               
                   
                 GCAGGGTGGGGAGAGGGATGGGACGAGAACCTGTGCTGGGGCCAAAG 
                   
               
               
                   
                 GTCGCACTGGGGGAAGGTGGAGCCAGGGCAGCAGAGTGCCTGGCGTCG 
                   
               
               
                   
                 GCCCCTATCCTGTCACTAGTTCCCCCGTTCTGGCCCCTGGCAGGTTTGTA 
                   
               
               
                   
                 ACCCCAGATCAGAAGTACTCCATGGACAACACTCCCCACACGCCAACC 
                   
               
               
                   
                 CCGTTCAAGAACGCCCTGGAGAAGTACGGACCCCTGAAGCCCCTGGTA 
                   
               
               
                   
                 CGTGGTGTGGTCACTGCCGTGGATCTCTGCACAGTGGGATCCCTTCGGT 
                   
               
               
                   
                 TCATCCAACCATGTTCAGTCCACAGGACCCTTCCCTCTGAGGTCTCATTT 
                   
               
               
                   
                 GATTCTTTCTCCTGAGAAGATGCAGAGATCCTGATAATATAAATGGGGA 
                   
               
               
                   
                 AGCTGAGGCTGCTCTTTGTCACTTCCTCCGACTGCTCCTGAGCACCTGA 
                   
               
               
                   
                 GTTTGCAAGCACGCGCCGGCTGGTGCTAGAGACATGGTGGTATCCCGTG 
                   
               
               
                   
                 ACACTCAGCCTCAGGATGGGGGAGACTGATGTGAAATACAAATAACTT 
                   
               
               
                   
                 AAACACTTTCAGGCAAAGATAAGCACTGGGCCTAGTTCAGAGAAGTGG 
                   
               
               
                   
                 CAAATTGCTACTCTGGCCTGTCTCTGACCAACTCCCAGTTCTCTACAGA 
                   
               
               
                   
                 GCACGGGAAAGCCCCTCGGGGACGTCTTTCCTGCAGTGTGCAGGCTGCC 
                   
               
               
                   
                 CTTCTCCCCTGCTCTTCCCAGTTGATGGGATGGTTGTGTTTTCTCTATGA 
                   
               
               
                   
                 AAAAAGGAGTTGGCACCTTGGGCTTTCTGAAACACACAGGTGTTTTAGA 
                   
               
               
                   
                 AATCAGTGGAGGGTGAGAGAAAGGCATGGTTGTGGAGGCACTGGACTG 
                   
               
               
                   
                 TGAACAAGGTCTGCAGCGGGTCCCCCTGCTGTCTCTCTCTACTGCATGG 
                   
               
               
                   
                 AGCCTCCTATGAAGCCCAAGGTGGCTGGGGGCTGAGGCTCCCTTGGGCC 
                   
               
               
                   
                 TGCCATGGAACTGATTCTGAGTCAAGCAGACTTTCCACGGACCATGCTA 
                   
               
               
                   
                 CATGAGCCGAGGTGAGGCACTAGTTAGTGCTCCTTTCCTGTTGCAGTGG 
                   
               
               
                   
                 AGATTTGGCTCCTCTGTACTAAAATATCTGCATGCTCTCCAAACAGGTG 
                   
               
               
                   
                 TGAGGGCAAATCACATGACCTTGGCAGCTGTAATTAAAGTTTGTGGGGG 
                   
               
               
                   
                 CTTTTCGGATGACTTATGAGGAGTGGCTGTGATTCGCACCTTTCACTCTT 
                   
               
               
                   
                 AGTAGCACTCGCCCTCCCCTGTTCTCTGTTGCCTGAAGCTGGAGAGGTC 
                   
               
               
                   
                 CTTGGAACCCCGAGGCCTGAGAAAGGGAAATGGGTTTGAGAGCCCCCA 
                   
               
               
                   
                 TTAGTGTGGAACAAAGGGTTGAGTGAGCCTGGGCTTTGAGCTGTCGGG 
                   
               
               
                   
                 GTCCTAATTCAGCAGCTGTGTGACTGTGTGCCAGGCTGTTGATCTCTGA 
                   
               
               
                   
                 GCTTCTGTTTCTACCTGCTTAAAATGACGGTTACTGCACAGGGCTGTGT 
                   
               
               
                   
                 GAGGGTTACAGTGCGTCTCTGGGCTGCTCCCAGCCATGGCAGGCCCCTG 
                   
               
               
                   
                 GGAATCAAGGTCATCAGCTGCTTGTCCAAGGCAGCAGTTAGTGGTTGTG 
                   
               
               
                   
                 AATGGTGCGTGTGAGATCTGCATCCTGGCGTCAGGCCTCCTTCCTGCCT 
                   
               
               
                   
                 TACCCAGGACAGCCCAGTTGCAGCTGGGTTGGTCCCACAGTCCCACACA 
                   
               
               
                   
                 CACACAGCCCGAGTGTGGTGCCTCACGTGGGCTGCCCCGTGCCTACCCA 
                   
               
               
                   
                 CAGCCACAGACCCCGCACCTGGAGGAGGACTTGAAGGAGGTGCTGCGT 
                   
               
               
                   
                 TCTGAGGCTGGCATCGAACTCATCATCGAGGACGACATCAGGCCCGAG 
                   
               
               
                   
                 AAGCAGAAGAGGAAGCCTGGGCTGCGGCGGAGCCCCATCAAGAAAGTC 
                   
               
               
                   
                 CGGAAGTCTCTGGCTCTTGACATTGTGGATGAGGATGTGAAGCTGATGA 
                   
               
               
                   
                 TGTCCACACTGCCCAAGTCTCTATCCTTGCCGACAACTGCCCCTTCAAA 
                   
               
               
                   
                 CTCTTCCAGCCTCACCCTGTCAGGTATCAAAGAAGACAACAGCTTGCTC 
                   
               
               
                   
                 AACCAGGGCTTCTTGCAGGCCAAGCCCGAGAAGGCAGCAGTGGCCCAG 
                   
               
               
                   
                 AAGCCCCGAAGCCACTTCACGACACCTGCCCCTATGTCCAGTGCCTGGA 
                   
               
               
                   
                 AGACGGTGGCCTGCGGGGGGACCAGGGACCAGCTTTTCATGCAGGAGA 
                   
               
               
                   
                 AAGCCCGGCAGCTCCTGGGCCGCCTGAAGCCCAGCCACACATCTCGGA 
                   
               
               
                   
                 CCCTCATCTTGTCCTGAGGTGTTGAGGGTGTCACGAGCCCATTCACATG 
                   
               
               
                   
                 TTTACAGGGGTTGTGGGGGCAGAGGGGGTCTGTGAATCTGAGAGTCATT 
                   
               
               
                   
                 CAGGTGACCTCCTGCAGGGAGCCTTCTGCCACCAGCCCCTCCCCAGACT 
                   
               
               
                   
                 CTCAGGTGGAGGCAACAGGGCCATGTGCTGCCCTGTTGCCGAGCCCAG 
                   
               
               
                   
                 CTGTGGGCGGCTCCTGGTGCTAACAACAAAGTTCCACTTCCAGGTCTGC 
                   
               
               
                   
                 CTGGTTCCCCCCCCAAGGCCACAGGGAGCTCCGTCAGCTTCTCCCAAGC 
                   
               
               
                   
                 CCACGTCAGGCCTGGCCTCATCTCAGACCCTGCTTAGGATGGGGGATGT 
                   
               
               
                   
                 GGCCAGGGGTGCTCCTGTGCTCACCCTCTCTTGGTGCATTTTTTTGGAAG 
                   
               
               
                   
                 AATAAAATTGCCTCTCTCTTTGAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_002467 
                 GACCCCCGAGCTGTGCTGCTCGCGGCCGCCACCGCCGGGCCCCGGCCGT 
                 186 
               
               
                   
                 CCCTGGCTCCCCTCCTGCCTCGAGAAGGGCAGGGCTTCTCAGAGGCTTG 
                   
               
               
                   
                 GCGGGAAAAAGAACGGAGGGAGGGATCGCGCTGAGTATAAAAGCCGG 
                   
               
               
                   
                 TTTTCGGGGCTTTATCTAACTCGCTGTAGTAATTCCAGCGAGAGGCAGA 
                   
               
               
                   
                 GGGAGCGAGCGGGCGGCCGGCTAGGGTGGAAGAGCCGGGCGAGCAGA 
                   
               
               
                   
                 GCTGCGCTGCGGGCGTCCTGGGAAGGGAGATCCGGAGCGAATAGGGGG 
                   
               
               
                   
                 CTTCGCCTCTGGCCCAGCCCTCCCGCTGATCCCCCAGCCAGCGGTCCGC 
                   
               
               
                   
                 AACCCTTGCCGCATCCACGAAACTTTGCCCATAGCAGCGGGCGGGCACT 
                   
               
               
                   
                 TTGCACTGGAACTTACAACACCCGAGCAAGGACGCGACTCTCCCGACG 
                   
               
               
                   
                 CGGGGAGGCTATTCTGCCCATTTGGGGACACTTCCCCGCCGCTGCCAGG 
                   
               
               
                   
                 ACCCGCTTCTCTGAAAGGCTCTCCTTGCAGCTGCTTAGACGCTGGATTTT 
                   
               
               
                   
                 TTTCGGGTAGTGGAAAACCAGCAGCCTCCCGCGACGATGCCCCTCAACG 
                   
               
               
                   
                 TTAGCTTCACCAACAGGAACTATGACCTCGACTACGACTCGGTGCAGCC 
                   
               
               
                   
                 GTATTTCTACTGCGACGAGGAGGAGAACTTCTACCAGCAGCAGCAGCA 
                   
               
               
                   
                 GAGCGAGCTGCAGCCCCCGGCGCCCAGCGAGGATATCTGGAAGAAATT 
                   
               
               
                   
                 CGAGCTGCTGCCCACCCCGCCCCTGTCCCCTAGCCGCCGCTCCGGGCTC 
                   
               
               
                   
                 TGCTCGCCCTCCTACGTTGCGGTCACACCCTTCTCCCTTCGGGGAGACA 
                   
               
               
                   
                 ACGACGGCGGTGGCGGGAGCTTCTCCACGGCCGACCAGCTGGAGATGG 
                   
               
               
                   
                 TGACCGAGCTGCTGGGAGGAGACATGGTGAACCAGAGTTTCATCTGCG 
                   
               
               
                   
                 ACCCGGACGACGAGACCTTCATCAAAAACATCATCATCCAGGACTGTAT 
                   
               
               
                   
                 GTGGAGCGGCTTCTCGGCCGCCGCCAAGCTCGTCTCAGAGAAGCTGGCC 
                   
               
               
                   
                 TCCTACCAGGCTGCGCGCAAAGACAGCGGCAGCCCGAACCCCGCCCGC 
                   
               
               
                   
                 GGCCACAGCGTCTGCTCCACCTCCAGCTTGTACCTGCAGGATCTGAGCG 
                   
               
               
                   
                 CCGCCGCCTCAGAGTGCATCGACCCCTCGGTGGTCTTCCCCTACCCTCTC 
                   
               
               
                   
                 AACGACAGCAGCTCGCCCAAGTCCTGCGCCTCGCAAGACTCCAGCGCCT 
                   
               
               
                   
                 TCTCTCCGTCCTCGGATTCTCTGCTCTCCTCGACGGAGTCCTCCCCGCAG 
                   
               
               
                   
                 GGCAGCCCCGAGCCCCTGGTGCTCCATGAGGAGACACCGCCCACCACC 
                   
               
               
                   
                 AGCAGCGACTCTGAGGAGGAACAAGAAGATGAGGAAGAAATCGATGTT 
                   
               
               
                   
                 GTTTCTGTGGAAAAGAGGCAGGCTCCTGGCAAAAGGTCAGAGTCTGGA 
                   
               
               
                   
                 TCACCTTCTGCTGGAGGCCACAGCAAACCTCCTCACAGCCCACTGGTCC 
                   
               
               
                   
                 TCAAGAGGTGCCACGTCTCCACACATCAGCACAACTACGCAGCGCCTCC 
                   
               
               
                   
                 CTCCACTCGGAAGGACTATCCTGCTGCCAAGAGGGTCAAGTTGGACAGT 
                   
               
               
                   
                 GTCAGAGTCCTGAGACAGATCAGCAACAACCGAAAATGCACCAGCCCC 
                   
               
               
                   
                 AGGTCCTCGGACACCGAGGAGAATGTCAAGAGGCGAACACACAACGTC 
                   
               
               
                   
                 TTGGAGCGCCAGAGGAGGAACGAGCTAAAACGGAGCTTTTTTGCCCTG 
                   
               
               
                   
                 CGTGACCAGATCCCGGAGTTGGAAAACAATGAAAAGGCCCCCAAGGTA 
                   
               
               
                   
                 GTTATCCTTAAAAAAGCCACAGCATACATCCTGTCCGTCCAAGCAGAGG 
                   
               
               
                   
                 AGCAAAAGCTCATTTCTGAAGAGGACTTGTTGCGGAAACGACGAGAAC 
                   
               
               
                   
                 AGTTGAAACACAAACTTGAACAGCTACGGAACTCTTGTGCGTAAGGAA 
                   
               
               
                   
                 AAGTAAGGAAAACGATTCCTTCTAACAGAAATGTCCTGAGCAATCACCT 
                   
               
               
                   
                 ATGAACTTGTTTCAAATGCATGATCAAATGCAACCTCACAACCTTGGCT 
                   
               
               
                   
                 GAGTCTTGAGACTGAAAGATTTAGCCATAATGTAAACTGCCTCAAATTG 
                   
               
               
                   
                 GACTTTGGGCATAAAAGAACTTTTTTATGCTTACCATCTTTTTTTTTTCTT 
                   
               
               
                   
                 TAACAGATTTGTATTTAAGAATTGTTTTTAAAAAATTTTAAGATTTACAC 
                   
               
               
                   
                 AATGTTTCTCTGTAAATATTGCCATTAAATGTAAATAACTTTAATAAAA 
                   
               
               
                   
                 CGTTTATAGCAGTTACACAGAATTTCAATCCTAGTATATAGTACCTAGT 
                   
               
               
                   
                 ATTATAGGTACTATAAACCCTAATTTTTTTTATTTAAGTACATTTTGCTT 
                   
               
               
                   
                 TTTAAAGTTGATTTTTTTCTATTGTTTTTAGAAAAAATAAAATAACTGGC 
                   
               
               
                   
                 AAATATATCATTGAGCCAAATCTTAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 BC013732 
                 GTGGGAGGATTGCATTCAGTCTAGTTCCTGGTTGCCGGCTGAAATAACC 
                 187 
               
               
                   
                 TGCTCTCCAAAATGTCCACAAAAGTGACTTAAGTCAGGTTCCCCCAAAC 
                   
               
               
                   
                 CAGACACCAAGACAAGAATCCATGTGTGTGTGACTGAAGGAAGTGCTG 
                   
               
               
                   
                 GGAGAGCCCCAGCTGCAGCCTGGATGTGAACTGCAACTCCAAAGTGTG 
                   
               
               
                   
                 TCCAGACTCAAGGCAAGGGCACTAGGCTTTCCAGACCTCCTACTAAGTC 
                   
               
               
                   
                 ATTGATCCAGCACTGCCCTGCCAGGACATAAATCCCTGGCACCTCTTGC 
                   
               
               
                   
                 TCTCTGCAAAGGAGGGCAAAGCAGCTTCAGGAGCCCTTGGGAGTCCTC 
                   
               
               
                   
                 CAAAGAGAGTCTAGGGTACAGGTCCGAAAGTAGAAGAACACAGAAGG 
                   
               
               
                   
                 CAGGCCAGGGGCACTGTGAGATGGTAAAAGAGATCTGAAGGGATCCAG 
                   
               
               
                   
                 AATTCAAGCCAGGAAGAAGCAGCAATCTGTCTTCTGGATTAAAACTGA 
                   
               
               
                   
                 AGATCAACCTACTTTCAACTTACTAAGAAAGGGGATCATGGACATTGAA 
                   
               
               
                   
                 GCATATCTTGAAAGAATTGGCTATAAGAAGTCTAGGAACAAATTGGAC 
                   
               
               
                   
                 TTGGAAACATTAACTGATATTCTTCAACACCAGATCCGAGCTGTTCCCT 
                   
               
               
                   
                 TTGAGAACCTTAACATCCATTGTGGGGATGCCATGGACTTAGGCTTAGA 
                   
               
               
                   
                 GGCCATTTTTGATCAAGTTGTGAGAAGAAATCGGGGTGGATGGTGTCTC 
                   
               
               
                   
                 CAGGTCAATCATCTTCTGTACTGGGCTCTGACCACTATTGGTTTTGAGAC 
                   
               
               
                   
                 CACGATGTTGGGAGGGTATGTTTACAGCACTCCAGCCAAAAAATACAG 
                   
               
               
                   
                 CACTGGCATGATTCACCTTCTCCTGCAGGTGACCATTGATGGCAGGAAC 
                   
               
               
                   
                 TACATTGTCGATGCTGGGTTTGGACGCTCATACCAGATGTGGCAGCCTC 
                   
               
               
                   
                 TGGAGTTAATTTCTGGGAAGGATCAGCCTCAGGTGCCTTGTGTCTTCCG 
                   
               
               
                   
                 TTTGACGGAAGAGAATGGATTCTGGTATCTAGACCAAATCAGAAGGGA 
                   
               
               
                   
                 ACAGTACATTCCAAATGAAGAATTTCTTCATTCTGATCTCCTAGAAGAC 
                   
               
               
                   
                 AGCAAATACCGAAAAATCTACTCCTTTACTCTTAAGCCTCGAACAATTG 
                   
               
               
                   
                 AAGATTTTGAGTCTATGAATACATACCTGCAGACATCTCCATCATCTGT 
                   
               
               
                   
                 GTTTACTAGTAAATCATTTTGTTCCTTGCAGACCCCAGATGGGGTTCACT 
                   
               
               
                   
                 GTTTGGTGGGCTTCACCCTCACCCATAGGAGATTCAATTATAAGGACAA 
                   
               
               
                   
                 TACAGATCTAATAGAGTTCAAGACTCTGAGTGAGGAAGAAATAGAAAA 
                   
               
               
                   
                 AGTGCTGAAAAATATATTTAATATTTCCTTGCAGAGAAAGCTTGTGCCC 
                   
               
               
                   
                 AAACATGGTGATAGATTTTTTACTATTTAGAATAAGGAGTAAAACAATC 
                   
               
               
                   
                 TTGTCTATTTGTCATCCAGCTCACCAGTTATCAACTGACGACCTATCATG 
                   
               
               
                   
                 TATCTTCTGTACCCTTACCTTATTTTGAAGAAAATCCTAGACATCAAATC 
                   
               
               
                   
                 ATTTCACCTATAAAAATGTCATCATATATAATTAAACAGCTTTTTAAAG 
                   
               
               
                   
                 AAACATAACCACAAACCTTTTCAAATAATAATAATAATAATAATAATAA 
                   
               
               
                   
                 ATGTCTTTTAAAGATGGCCTGTGGTTATCTTGGAAATTGGTGATTTATGC 
                   
               
               
                   
                 TAGAAAGCTTTTAATGTTGGTTTATTGTTGAATTCCTAGAAAAGTTTTAT 
                   
               
               
                   
                 GGGTAGATGAGTAAATAAAATATTGTAAAAAAACTTATTGTCTATAAA 
                   
               
               
                   
                 GTATATTAAAACATTGTTGGCTAATATAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_014321 
                 GCGCGCGGGTTTCGTTGACCCGCGGCGTTCACGGGAATTGTTCGCTTTA 
                 188 
               
               
                   
                 GTGCCGGCGCCATGGGGTCGGAGCTGATCGGGCGCCTAGCCCCGCGCC 
                   
               
               
                   
                 TGGGCCTCGCCGAGCCCGACATGCTGAGGAAAGCAGAGGAGTACTTGC 
                   
               
               
                   
                 GCCTGTCCCGGGTGAAGTGTGTCGGCCTCTCCGCACGCACCACGGAGAC 
                   
               
               
                   
                 CAGCAGTGCAGTCATGTGCCTGGACCTTGCAGCTTCCTGGATGAAGTGC 
                   
               
               
                   
                 CCCTTGGACAGGGCTTATTTAATTAAACTTTCTGGTTTGAACAAGGAGA 
                   
               
               
                   
                 CATATCAGAGCTGTCTTAAATCTTTTGAGTGTTTACTGGGCCTGAATTCA 
                   
               
               
                   
                 AATATTGGAATAAGAGACCTAGCTGTACAGTTTAGCTGTATAGAAGCA 
                   
               
               
                   
                 GTGAACATGGCTTCAAAGATACTAAAAAGCTATGAGTCCAGTCTTCCCC 
                   
               
               
                   
                 AGACACAGCAAGTGGATCTTGACTTATCCAGGCCACTTTTCACTTCTGC 
                   
               
               
                   
                 TGCACTGCTTTCAGCATGCAAGATTCTAAAGCTGAAAGTGGATAAAAAC 
                   
               
               
                   
                 AAAATGGTAGCCACATCCGGTGTAAAAAAAGCTATATTTGATCGACTGT 
                   
               
               
                   
                 GTAAACAACTAGAGAAGATTGGACAGCAGGTCGACAGAGAACCTGGAG 
                   
               
               
                   
                 ATGTAGCTACTCCACCACGGAAGAGAAAGAAGATAGTGGTTGAAGCCC 
                   
               
               
                   
                 CAGCAAAGGAAATGGAGAAGGTAGAGGAGATGCCACATAAACCACAG 
                   
               
               
                   
                 AAAGATGAAGATCTGACACAGGATTATGAAGAATGGAAAAGAAAAATT 
                   
               
               
                   
                 TTGGAAAATGCTGCCAGTGCTCAAAAGGCTACAGCAGAGTGATTTCAG 
                   
               
               
                   
                 CTTCCAAACTGGTATACATTCCAAACTGATAGTACATTGCCATCTCCAG 
                   
               
               
                   
                 GAAGACTTGACGGCTTTGGGATTTTGTTTAAACTTTTATAATAAGGATC 
                   
               
               
                   
                 CTAAGACTGTTGCCTTTAAATAGCAAAGCAGCCTACCTGGAGGCTAAGT 
                   
               
               
                   
                 CTGGGCAGTGGGCTGGCCCCTGGTGTGAGCATTAGACCAGCCACAGTG 
                   
               
               
                   
                 CCTGATTGGTATAGCCTTATGTGCTTTCCTACAAAATGGAATTGGAGGC 
                   
               
               
                   
                 CGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAG 
                   
               
               
                   
                 GTGGGTGGATCACCTGAGGTCAGGAGCTCGAGACCAGCCTGGCCAACA 
                   
               
               
                   
                 TGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGAT 
                   
               
               
                   
                 GGTGCATGCCTGTAATCCCAGCTCCTCAGTAGGCTGAGACAGGAGCATC 
                   
               
               
                   
                 ACTTGAACGTGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCACCACC 
                   
               
               
                   
                 GCACTCCAGCCTGGGTGACAGAGCGAGACTTATCTCATAAATAAATAG 
                   
               
               
                   
                 ATAGATACTCCAGCCTGGGTGACAGAGCGAGACTTATAGATAGATAGA 
                   
               
               
                   
                 TAGATAGATGGATAGATAGATAGATAGATAGATAGATAGATAAACGGA 
                   
               
               
                   
                 ATTGGAGCCATTTTGCTTTAAGTGAATGGCAGTCCCTTGTCTTATTCAGA 
                   
               
               
                   
                 ATATAAAATTCAGTCTGAATGGCATCTTACAGATTTTACTTCAATTTTTG 
                   
               
               
                   
                 TGTACGGTATTTTTTATTTGACTAAATCAATATATTGTACAGCCTAAGTT 
                   
               
               
                   
                 AATAAATGTTATTTATATATGCAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_000926 
                 AGTCCACAGCTGTCACTAATCGGGGTAAGCCTTGTTGTATTTGTGCGTG 
                 189 
               
               
                   
                 TGGGTGGCATTCTCAATGAGAACTAGCTTCACTTGTCATTTGAGTGAAA 
                   
               
               
                   
                 TCTACAACCCGAGGCGGCTAGTGCTCCCGCACTACTGGGATCTGAGATC 
                   
               
               
                   
                 TTCGGAGATGACTGTCGCCCGCAGTACGGAGCCAGCAGAAGTCCGACC 
                   
               
               
                   
                 CTTCCTGGGAATGGGCTGTACCGAGAGGTCCGACTAGCCCCAGGGTTTT 
                   
               
               
                   
                 AGTGAGGGGGCAGTGGAACTCAGCGAGGGACTGAGAGCTTCACAGCAT 
                   
               
               
                   
                 GCACGAGTTTGATGCCAGAGAAAAAGTCGGGAGATAAAGGAGCCGCGT 
                   
               
               
                   
                 GTCACTAAATTGCCGTCGCAGCCGCAGCCACTCAAGTGCCGGACTTGTG 
                   
               
               
                   
                 AGTACTCTGCGTCTCCAGTCCTCGGACAGAAGTTGGAGAACTCTCTTGG 
                   
               
               
                   
                 AGAACTCCCCGAGTTAGGAGACGAGATCTCCTAACAATTACTACTTTTT 
                   
               
               
                   
                 CTTGCGCTCCCCACTTGCCGCTCGCTGGGACAAACGACAGCCACAGTTC 
                   
               
               
                   
                 CCCTGACGACAGGATGGAGGCCAAGGGCAGGAGCTGACCAGCGCCGCC 
                   
               
               
                   
                 CTCCCCCGCCCCCGACCCAGGAGGTGGAGATCCCTCCGGTCCAGCCACA 
                   
               
               
                   
                 TTCAACACCCACTTTCTCCTCCCTCTGCCCCTATATTCCCGAAACCCCCT 
                   
               
               
                   
                 CCTCCTTCCCTTTTCCCTCCTCCTGGAGACGGGGGAGGAGAAAAGGGGA 
                   
               
               
                   
                 GTCCAGTCGTCATGACTGAGCTGAAGGCAAAGGGTCCCCGGGCTCCCC 
                   
               
               
                   
                 ACGTGGCGGGCGGCCCGCCCTCCCCCGAGGTCGGATCCCCACTGCTGTG 
                   
               
               
                   
                 TCGCCCAGCCGCAGGTCCGTTCCCGGGGAGCCAGACCTCGGACACCTTG 
                   
               
               
                   
                 CCTGAAGTTTCGGCCATACCTATCTCCCTGGACGGGCTACTCTTCCCTCG 
                   
               
               
                   
                 GCCCTGCCAGGGACAGGACCCCTCCGACGAAAAGACGCAGGACCAGCA 
                   
               
               
                   
                 GTCGCTGTCGGACGTGGAGGGCGCATATTCCAGAGCTGAAGCTACAAG 
                   
               
               
                   
                 GGGTGCTGGAGGCAGCAGTTCTAGTCCCCCAGAAAAGGACAGCGGACT 
                   
               
               
                   
                 GCTGGACAGTGTCTTGGACACTCTGTTGGCGCCCTCAGGTCCCGGGCAG 
                   
               
               
                   
                 AGCCAACCCAGCCCTCCCGCCTGCGAGGTCACCAGCTCTTGGTGCCTGT 
                   
               
               
                   
                 TTGGCCCCGAACTTCCCGAAGATCCACCGGCTGCCCCCGCCACCCAGCG 
                   
               
               
                   
                 GGTGTTGTCCCCGCTCATGAGCCGGTCCGGGTGCAAGGTTGGAGACAGC 
                   
               
               
                   
                 TCCGGGACGGCAGCTGCCCATAAAGTGCTGCCCCGGGGCCTGTCACCA 
                   
               
               
                   
                 GCCCGGCAGCTGCTGCTCCCGGCCTCTGAGAGCCCTCACTGGTCCGGGG 
                   
               
               
                   
                 CCCCAGTGAAGCCGTCTCCGCAGGCCGCTGCGGTGGAGGTTGAGGAGG 
                   
               
               
                   
                 AGGATGGCTCTGAGTCCGAGGAGTCTGCGGGTCCGCTTCTGAAGGGCA 
                   
               
               
                   
                 AACCTCGGGCTCTGGGTGGCGCGGCGGCTGGAGGAGGAGCCGCGGCTG 
                   
               
               
                   
                 TCCCGCCGGGGGCGGCAGCAGGAGGCGTCGCCCTGGTCCCCAAGGAAG 
                   
               
               
                   
                 ATTCCCGCTTCTCAGCGCCCAGGGTCGCCCTGGTGGAGCAGGACGCGCC 
                   
               
               
                   
                 GATGGCGCCCGGGCGCTCCCCGCTGGCCACCACGGTGATGGATTTCATC 
                   
               
               
                   
                 CACGTGCCTATCCTGCCTCTCAATCACGCCTTATTGGCAGCCCGCACTC 
                   
               
               
                   
                 GGCAGCTGCTGGAAGACGAAAGTTACGACGGCGGGGCCGGGGCTGCCA 
                   
               
               
                   
                 GCGCCTTTGCCCCGCCGCGGAGTTCACCCTGTGCCTCGTCCACCCCGGT 
                   
               
               
                   
                 CGCTGTAGGCGACTTCCCCGACTGCGCGTACCCGCCCGACGCCGAGCCC 
                   
               
               
                   
                 AAGGACGACGCGTACCCTCTCTATAGCGACTTCCAGCCGCCCGCTCTAA 
                   
               
               
                   
                 AGATAAAGGAGGAGGAGGAAGGCGCGGAGGCCTCCGCGCGCTCCCCGC 
                   
               
               
                   
                 GTTCCTACCTTGTGGCCGGTGCCAACCCCGCAGCCTTCCCGGATTTCCC 
                   
               
               
                   
                 GTTGGGGCCACCGCCCCCGCTGCCGCCGCGAGCGACCCCATCCAGACCC 
                   
               
               
                   
                 GGGGAAGCGGCGGTGACGGCCGCACCCGCCAGTGCCTCAGTCTCGTCT 
                   
               
               
                   
                 GCGTCCTCCTCGGGGTCGACCCTGGAGTGCATCCTGTACAAAGCGGAGG 
                   
               
               
                   
                 GCGCGCCGCCCCAGCAGGGCCCGTTCGCGCCGCCGCCCTGCAAGGCGC 
                   
               
               
                   
                 CGGGCGCGAGCGGCTGCCTGCTCCCGCGGGACGGCCTGCCCTCCACCTC 
                   
               
               
                   
                 CGCCTCTGCCGCCGCCGCCGGGGCGGCCCCCGCGCTCTACCCTGCACTC 
                   
               
               
                   
                 GGCCTCAACGGGCTCCCGCAGCTCGGCTACCAGGCCGCCGTGCTCAAG 
                   
               
               
                   
                 GAGGGCCTGCCGCAGGTCTACCCGCCCTATCTCAACTACCTGAGGCCGG 
                   
               
               
                   
                 ATTCAGAAGCCAGCCAGAGCCCACAATACAGCTTCGAGTCATTACCTCA 
                   
               
               
                   
                 GAAGATTTGTTTAATCTGTGGGGATGAAGCATCAGGCTGTCATTATGGT 
                   
               
               
                   
                 GTCCTTACCTGTGGGAGCTGTAAGGTCTTCTTTAAGAGGGCAATGGAAG 
                   
               
               
                   
                 GGCAGCACAACTACTTATGTGCTGGAAGAAATGACTGCATCGTTGATAA 
                   
               
               
                   
                 AATCCGCAGAAAAAACTGCCCAGCATGTCGCCTTAGAAAGTGCTGTCA 
                   
               
               
                   
                 GGCTGGCATGGTCCTTGGAGGTCGAAAATTTAAAAAGTTCAATAAAGTC 
                   
               
               
                   
                 AGAGTTGTGAGAGCACTGGATGCTGTTGCTCTCCCACAGCCAGTGGGCG 
                   
               
               
                   
                 TTCCAAATGAAAGCCAAGCCCTAAGCCAGAGATTCACTTTTTCACCAGG 
                   
               
               
                   
                 TCAAGACATACAGTTGATTCCACCACTGATCAACCTGTTAATGAGCATT 
                   
               
               
                   
                 GAACCAGATGTGATCTATGCAGGACATGACAACACAAAACCTGACACC 
                   
               
               
                   
                 TCCAGTTCTTTGCTGACAAGTCTTAATCAACTAGGCGAGAGGCAACTTC 
                   
               
               
                   
                 TTTCAGTAGTCAAGTGGTCTAAATCATTGCCAGGTTTTCGAAACTTACA 
                   
               
               
                   
                 TATTGATGACCAGATAACTCTCATTCAGTATTCTTGGATGAGCTTAATG 
                   
               
               
                   
                 GTGTTTGGTCTAGGATGGAGATCCTACAAACACGTCAGTGGGCAGATGC 
                   
               
               
                   
                 TGTATTTTGCACCTGATCTAATACTAAATGAACAGCGGATGAAAGAATC 
                   
               
               
                   
                 ATCATTCTATTCATTATGCCTTACCATGTGGCAGATCCCACAGGAGTTTG 
                   
               
               
                   
                 TCAAGCTTCAAGTTAGCCAAGAAGAGTTCCTCTGTATGAAAGTATTGTT 
                   
               
               
                   
                 ACTTCTTAATACAATTCCTTTGGAAGGGCTACGAAGTCAAACCCAGTTT 
                   
               
               
                   
                 GAGGAGATGAGGTCAAGCTACATTAGAGAGCTCATCAAGGCAATTGGT 
                   
               
               
                   
                 TTGAGGCAAAAAGGAGTTGTGTCGAGCTCACAGCGTTTCTATCAACTTA 
                   
               
               
                   
                 CAAAACTTCTTGATAACTTGCATGATCTTGTCAAACAACTTCATCTGTAC 
                   
               
               
                   
                 TGCTTGAATACATTTATCCAGTCCCGGGCACTGAGTGTTGAATTTCCAG 
                   
               
               
                   
                 AAATGATGTCTGAAGTTATTGCTGCACAATTACCCAAGATATTGGCAGG 
                   
               
               
                   
                 GATGGTGAAACCCCTTCTCTTTCATAAAAAGTGAATGTCATCTTTTTCTT 
                   
               
               
                   
                 TTAAAGAATTAAATTTTGTGGTATGTCTTTTTGTTTTGGTCAGGATTATG 
                   
               
               
                   
                 AGGTCTTGAGTTTTTATAATGTTCTTCTGAAAGCCTTACATTTATAACAT 
                   
               
               
                   
                 CATAGTGTGTAAATTTAAAAGAAAAATTGTGAGGTTCTAATTATTTTCT 
                   
               
               
                   
                 TTTATAAAGTATAATTAGAATGTTTAACTGTTTTGTTTACCCATATTTTC 
                   
               
               
                   
                 TTGAAGAATTTACAAGATTGAAAAAGTACTAAAATTGTTAAAGTAAACT 
                   
               
               
                   
                 ATCTTATCCATATTATTTCATACCATGTAGGTGAGGATTTTTAACTTTTG 
                   
               
               
                   
                 CATCTAACAAATCATCGACTTAAGAGAAAAAATCTTACATGTAATAACA 
                   
               
               
                   
                 CAAAGCTATTATATGTTATTTCTAGGTAACTCCCTTTGTGTCAATTATAT 
                   
               
               
                   
                 TTCCAAAAATGAACCTTTAAAATGGTATGCAAAATTTTGTCTATATATA 
                   
               
               
                   
                 TTTGTGTGAGGAGGAAATTCATAACTTTCCTCAGATTTTCAAAAGTATTT 
                   
               
               
                   
                 TTAATGCAAAAAATGTAGAAAGAGTTTAAAACCACTAAAATAGATTGA 
                   
               
               
                   
                 TGTTCTTCAAACTAGGCAAAACAACTCATATGTTAAGACCATTTTCCAG 
                   
               
               
                   
                 ATTGGAAACACAAATCTCTTAGGAAGTTAATAAGTAGATTCATATCATT 
                   
               
               
                   
                 ATGCAAATAGTATTGTGGGTTTTGTAGGTTTTTAAAATAACCTTTTTTGG 
                   
               
               
                   
                 GGAGAGAATTGTCCTCTAATGAGGTATTGCGAGTGGACATAAGAAATC 
                   
               
               
                   
                 AGAAGATTATGGCCTAACTGTACTCCTTACCAACTGTGGCATGCTGAAA 
                   
               
               
                   
                 GTTAGTCACTCTTACTGATTCTCAATTCTCTCACCTTTGAAAGTAGTAAA 
                   
               
               
                   
                 ATATCTTTCCTGCCAATTGCTCCTTTGGGTCAGAGCTTATTAACATCTTT 
                   
               
               
                   
                 TCAAATCAAAGGAAAGAAGAAAGGGAGAGGAGGAGGAGGGAGGTATC 
                   
               
               
                   
                 AATTCACATACCTTTCTCCTCTTTATCCTCCACTATCATGAATTCATATT 
                   
               
               
                   
                 ATGTTTCAGCCATGCAAATCTTTTTACCATGAAATTTCTTCCAGAATTTT 
                   
               
               
                   
                 CCCCCTTTGACACAAATTCCATGCATGTTTCAACCTTCGAGACTCAGCC 
                   
               
               
                   
                 AAATGTCATTTCTGTAAAATCTTCCCTGAGTCTTCCAAGCAGTAATTTGC 
                   
               
               
                   
                 CTTCTCCTAGAGTTTACCTGCCATTTTGTGCACATTTGAGTTACAGTAGC 
                   
               
               
                   
                 ATGTTATTTTACAATTGTGACTCTCCTGGGAGTCTGGGAGCCATATAAA 
                   
               
               
                   
                 GTGGTCAATAGTGTTTGCTGACTGAGAGTTGAATGACATTTTCTCTCTGT 
                   
               
               
                   
                 CTTGGTATTACTGTAGATTTCGATCATTCTTTGGTTACATTTCTGCATAT 
                   
               
               
                   
                 TTCTGTACCCATGACTTTATCACTTTCTTCTCCCATGCTTTATCTCCATCA 
                   
               
               
                   
                 ATTATCTTCATTACTTTTAAATTTTCCACCTTTGCTTCCTACTTTGTGAGA 
                   
               
               
                   
                 TCTCTCCCTTTACTGACTATAACATAGAAGAATAGAAGTGTATTTTATGT 
                   
               
               
                   
                 GTCTTAAGGACAATACTTTAGATTCCTTGTTCTAAGTTTTTAAACTGAAT 
                   
               
               
                   
                 GAATGGAATATTATTTCTCTCCCTAAGCAAAATTCCACAAAACAATTAT 
                   
               
               
                   
                 TTCTTATGTTTATGTAGCCTTAAATTGTTTTGTACTGTAAACCTCAGCAT 
                   
               
               
                   
                 AAAAACTTTCTTCATTTCTAATTTCATTCAACAAATATTGATTGAATACC 
                   
               
               
                   
                 TGGTATTAGCACAAGAAAAATGTGCTAATAAGCCTTATGAGAATTTGGA 
                   
               
               
                   
                 GCTGAAGAAAGACATATAACTCAGGAAAGTTACAGTCCAGTAGTAGGT 
                   
               
               
                   
                 ATAAATTACAGTGCCTGATAAATAGGCATTTTAATATTTGTACACTCAA 
                   
               
               
                   
                 CGTATACTAGGTAGGTGCAAAACATTTACATATAATTTTACTGATACCC 
                   
               
               
                   
                 ATGCAGCACAAAGGTACTAACTTTAAATATTAAATAACACCTTTATGTG 
                   
               
               
                   
                 TCAGTAATTCATTTGCATTAAATCTTATTGAAAAGGCTTTCAATATATTT 
                   
               
               
                   
                 TCCCCACAAATGTCATCCCAAGAAAAAAGTATTTTTAACATCTCCCAAA 
                   
               
               
                   
                 TATAATAGTTACAGGAAATCTACCTCTGTGAGAGTGACACCTCTCAGAA 
                   
               
               
                   
                 TGAACTGTGTGACACAAGAAAATGAATGTAGGTCTATCCAAAAAAAAC 
                   
               
               
                   
                 CCCAAGAAACAAAAACAATATTATTAGCCCTTTATGCTTAAGTGATGGA 
                   
               
               
                   
                 CTCAGGGAACAGTTGATGTTGTGATCATTTTATTATCTGATTCTTGTTAC 
                   
               
               
                   
                 TTTGAATTAAACCAATATTTTGATGATATAAATCATTTCCACCAGCATAT 
                   
               
               
                   
                 ATTTAATTTCCATAATAACTTTAAAATTTTCTAATTTCACTCAACTATGA 
                   
               
               
                   
                 GGGAATAGAATGTGGTGGCCACAGGTTTGGCTTTTGTTAAAATGTTTGA 
                   
               
               
                   
                 TATCTTCGATGTTGATCTCTGTCTGCAATGTAGATGTCTAAACACTAGG 
                   
               
               
                   
                 ATTTAATATTTAAGGCTAAGCTTTAAAAATAAAGTACCTTTTTAAAAAG 
                   
               
               
                   
                 AATATGGCTTCACCAAATGGAAAATACCTAATTTCTAAATCTTTTTCTCT 
                   
               
               
                   
                 ACAAAGTCCTATCTACTAATGTCTCCATTACTATTTAGTCATCATAACCA 
                   
               
               
                   
                 TTATCTTCATTTTACATGTCGTGTTCTTTCTGGTAGCTCTAAAATGACAC 
                   
               
               
                   
                 TAAATCATAAGAAGACAGGTTACATATCAGGAAATACTTGAAGGTTAC 
                   
               
               
                   
                 TGAAATAGATTCTTGAGTTAATGAAAATATTTTCTGTAAAAAGGTTTGA 
                   
               
               
                   
                 AAAGCCATTTGAGTCTAAAGCATTATACCTCCATTATCAGTAGTTATGT 
                   
               
               
                   
                 GACAATTGTGTGTGTGTTTAATGTTTAAAGATGTGGCACTTTTTAATAA 
                   
               
               
                   
                 GGCAATGCTATGCTATTTTTTCCCATTTAACATTAAGATAATTTATTGCT 
                   
               
               
                   
                 ATACAGATGATATGGAAATATGATGAACAATATTTTTTTTGCCAAAACT 
                   
               
               
                   
                 ATGCCTTGTAAGTAGCCATGGAATGTCAACCTGTAACTTAAATTATCCA 
                   
               
               
                   
                 CAGATAGTCATGTGTTTGATGATGGGCACTGTGGAGATAACTGACATAG 
                   
               
               
                   
                 GACTGTGCCCCCCTTCTCTGCCACTTACTAGCTGGATGAGATTAAGCAA 
                   
               
               
                   
                 GTCATTTAACTGCTCTGATTAAACCTGCCTTTCCCAAGTGCTTTGTAATG 
                   
               
               
                   
                 AATAGAAATGGAAACCAAAAAAAACGTATACAGGCCTTCAGAAATAGT 
                   
               
               
                   
                 AATTGCTACTATTTTGTTTTCATTAAGCCATAGTTCTGGCTATAATTTTA 
                   
               
               
                   
                 TCAAACTCACCAGCTATATTCTACAGTGAAAGCAGGATTCTAGAAAGTC 
                   
               
               
                   
                 TCACTGTTTTATTTATGTCACCATGTGCTATGATATATTTGGTTGAATTC 
                   
               
               
                   
                 ATTTGAAATTAGGGCTGGAAGTATTCAAGTAATTTCTTCTGCTGAAAAA 
                   
               
               
                   
                 ATACAGTGTTTTGAGTTTAGGGCCTGTTTTATCAAAGTTCTAAAGAGCC 
                   
               
               
                   
                 TATCACTCTTCCATTGTAGACATTTTAAAATAATGACACTGATTTTAACA 
                   
               
               
                   
                 TTTTTAAGTGTCTTTTTAGAACAGAGAGCCTGACTAGAACACAGCCCCT 
                   
               
               
                   
                 CCAAAAACCCATGCTCAAATTATTTTTACTATGGCAGCAATTCCACAAA 
                   
               
               
                   
                 AGGGAACAATGGGTTTAGAAATTACAATGAAGTCATCAACCCAAAAAA 
                   
               
               
                   
                 CATCCCTATCCCTAAGAAGGTTATGATATAAAATGCCCACAAGAAATCT 
                   
               
               
                   
                 ATGTCTGCTTTAATCTGTCTTTTATTGCTTTGGAAGGATGGCTATTACAT 
                   
               
               
                   
                 TTTTAGTTTTTGCTGTGAATACCTGAGCAGTTTCTCTCATCCATACTTAT 
                   
               
               
                   
                 CCTTCACACATCAGAAGTCAGGATAGAATATGAATCATTTTAAAAACTT 
                   
               
               
                   
                 TTACAACTCCAGAGCCATGTGCATAAGAAGCATTCAAAACTTGCCAAA 
                   
               
               
                   
                 ACATACATTTTTTTTCAAATTTAAAGATACTCTATTTTTGTATTCAATAG 
                   
               
               
                   
                 CTCAACAACTGTGGTCCCCACTGATAAAGTGAAGTGGACAAGGAGACA 
                   
               
               
                   
                 AGTAATGGCATAAGTTTGTTTTTCCCAAAGTATGCCTGTTCAATAGCCA 
                   
               
               
                   
                 TTGGATGTGGGAAATTTCTACATCTCTTAAAATTTTACAGAAAATACAT 
                   
               
               
                   
                 AGCCAGATAGTCTAGCAAAAGTTCACCAAGTCCTAAATTGCTTATCCTT 
                   
               
               
                   
                 ACTTCACTAAGTCATGAAATCATTTTAATGAAAAGAACATCACCTAGGT 
                   
               
               
                   
                 TTTGTGGTTTCTTTTTTTCTTATTCATGGCTGAGTGAAAACAACAATCTC 
                   
               
               
                   
                 TGTTTCTCCCTAGCATCTGTGGACTATTTAATGTACCATTATTCCACACT 
                   
               
               
                   
                 CTATGGTCCTTACTAAATACAAAATTGAACAAAAAGCAGTAAAACAAC 
                   
               
               
                   
                 TGACTCTTCACCCATATTATAAAATATAATCCAAGCCAGATTAGTCAAC 
                   
               
               
                   
                 ATCCATAAGATGAATCCAAGCTGAACTGGGCCTAGATTATTGAGTTCAG 
                   
               
               
                   
                 GTTGGATCACATCCCTATTTATTAATAAACTTAGGAAAGAAGGCCTTAC 
                   
               
               
                   
                 AGACCATCAGTTAGCTGGAGCTAATAGAACCTACACTTCTAAAGTTCGG 
                   
               
               
                   
                 CCTAGAATCAATGTGGCCTTAAAAGCTGAAAAGAAGCAGGAAAGAACA 
                   
               
               
                   
                 GTTTTCTTCAATAATTTGTCCACCCTGTCACTGGAGAAAATTTAAGAATT 
                   
               
               
                   
                 TGGGGGTGTTGGTAGTAAGTTAAACACAGCAGCTGTTCATGGCAGAAA 
                   
               
               
                   
                 TTATTCAATACATACCTTCTCTGAATATCCTATAACCAAAGCAAAGAAA 
                   
               
               
                   
                 AACACCAAGGGGTTTGTTCTCCTCCTTGGAGTTGACCTCATTCCAAGGC 
                   
               
               
                   
                 AGAGCTCAGGTCACAGGCACAGGGGCTGCGCCCAAGCTTGTCCGCAGC 
                   
               
               
                   
                 CTTATGCAGCTGTGGAGTCTGGAAGACTGTTGCAGGACTGCTGGCCTAG 
                   
               
               
                   
                 TCCCAGAATGTCAGCCTCATTTTCGATTTACTGGCTCTTGTTGCTGTATG 
                   
               
               
                   
                 TCATGCTGACCTTATTGTTAAACACAGGTTTGTTTGCTTTTTTTCCACTC 
                   
               
               
                   
                 ATGGAGACATGGGAGAGGCATTATTTTTAAGCTGGTTGAAAGCTTTAAC 
                   
               
               
                   
                 CGATAAAGCATTTTTAGAGAAATGTGAATCAGGCAGCTAAGAAAGCAT 
                   
               
               
                   
                 ACTCTGTCCATTACGGTAAAGAAAATGCACAGATTATTAACTCTGCAGT 
                   
               
               
                   
                 GTGGCATTAGTGTCCTGGTCAATATTCGGATAGATATGAATAAAATATT 
                   
               
               
                   
                 TAAATGGTATTGTAAATAGTTTTCAGGACATATGCTATAGCTTATTTTTA 
                   
               
               
                   
                 TTATCTTTTGAAATTGCTCTTAATACATCAAATCCTGATGTATTCAATTT 
                   
               
               
                   
                 ATCAGATATAAATTATTCTAAATGAAGCCCAGTTAAATGTTTTTGTCTTG 
                   
               
               
                   
                 TCAGTTATATGTTAAGTTTCTGATCTCTTTGTCTATGACGTTTACTAATC 
                   
               
               
                   
                 TGCATTTTTACTGTTATGAATTATTTTAGACAGCAGTGGTTTCAAGCTTT 
                   
               
               
                   
                 TTGCCACTAAAAATACCTTTTATTTTCTCCTCCCCCAGAAAAGTCTATAC 
                   
               
               
                   
                 CTTGAAGTATCTATCCACCAAACTGTACTTCTATTAAGAAATAGTTATT 
                   
               
               
                   
                 GTGTTTTCTTAATGTTTTGTTATTCAAAGACATATCAATGAAAGCTGCTG 
                   
               
               
                   
                 AGCAGCATGAATAACAATTATATCCACACAGATTTGATATATTTTGTGC 
                   
               
               
                   
                 AGCCTTAACTTGATAGTATAAAATGTCATTGCTTTTTAAATAATAGTTA 
                   
               
               
                   
                 GTCAATGGACTTCTATCATAGCTTTCCTAAACTAGGTTAAGATCCAGAG 
                   
               
               
                   
                 CTTTGGGGTCATAATATATTACATACAATTAAGTTATCTTTTTCTAAGGG 
                   
               
               
                   
                 CTTTAAAATTCATGAGAATAACCAAAAAAGGTATGTGGAGAGTTAATA 
                   
               
               
                   
                 CAAACATACCATATTCTTGTTGAAACAGAGATGTGGCTCTGCTTGTTCT 
                   
               
               
                   
                 CCATAAGGTAGAAATACTTTCCAGAATTTGCCTAAACTAGTAAGCCCTG 
                   
               
               
                   
                 AATTTGCTATGATTAGGGATAGGAAGAGATTTTCACATGGCAGACTTTA 
                   
               
               
                   
                 GAATTCTTCACTTTAGCCAGTAAAGTATCTCCTTTTGATCTTAGTATTCT 
                   
               
               
                   
                 GTGTATTTTAACTTTTCTGAGTTGTGCATGTTTATAAGAAAAATCAGCAC 
                   
               
               
                   
                 AAAGGGTTTAAGTTAAAGCCTTTTTACTGAAATTTGAAAGAAACAGAA 
                   
               
               
                   
                 GAAAATATCAAAGTTCTTTGTATTTTGAGAGGATTAAATATGATTTACA 
                   
               
               
                   
                 AAAGTTACATGGAGGGCTCTCTAAAACATTAAATTAATTATTTTTTGTT 
                   
               
               
                   
                 GAAAAGTCTTACTTTAGGCATCATTTTATTCCTCAGCAACTAGCTGTGA 
                   
               
               
                   
                 AGCCTTTACTGTGCTGTATGCCAGTCACTCTGCTAGATTGTGGAGATTA 
                   
               
               
                   
                 CCAGTGTTCCCGTCTTCTCCGAGCTTAGAGTTGGATGGGGAATAAAGAC 
                   
               
               
                   
                 AGGTAAACAGATAGCTACAATATTGTACTGTGAATGCTTATGCTGGAGG 
                   
               
               
                   
                 AAGTACAGGGAACTATTGGAGCACCTAAGAGGAGCACCTACCTTGAAT 
                   
               
               
                   
                 TTAGGGGTTAGCAGAGGCATCCTGAAAAAAGTCAAAGCTAAGCCACAA 
                   
               
               
                   
                 TCTATAAGCAGTTTAGGAATTAGCAGAACGTGCGTGGTGAGGAGATGC 
                   
               
               
                   
                 CAAAGGCAAGAAGAGAAGAGTATTCCAAACAGGAGGGATTCCAAAGA 
                   
               
               
                   
                 GAGAAGAGTATCCCAAACAACATTTGCACAAACCTGATGGGGAGAGAG 
                   
               
               
                   
                 AATGTGGGGTGGGGATGGATGATGAGACTGAAGAAGAAAGCCAGGTCT 
                   
               
               
                   
                 AGATAATCAGTGGCCTTGTACACCATGTTAAAGAGTGTAGACTTGATTC 
                   
               
               
                   
                 TGTTGTAAACAGGAAAGCAGCACAATTCATATGAATATTTTAGAAGACT 
                   
               
               
                   
                 CCCACTGGAATATGGAGAATAAAGTTGGAGATGACTAATCCTGGAAGC 
                   
               
               
                   
                 AGGGAGAACATTTTTGAGGAAGTTGCACTATTTTGGTGAAAATGATGAT 
                   
               
               
                   
                 CATAAACATGAAGAATTGTAGGTGATCATGACCTCCTCTCTAATTTTCC 
                   
               
               
                   
                 AGAAGGGTTTTGGAAGATATAACATAGGAACATTGACAGGACTGACGA 
                   
               
               
                   
                 AAGGAGATGAAATACACCATATAAATTGTCAAACACAAGGCCAGATGT 
                   
               
               
                   
                 CTAATTATTTTGCTTATGTGTTGAAATTACAAATTTTTCATCAGGAAACC 
                   
               
               
                   
                 AAAAACTACAAAACTTAGTTTTCCCAAGTCCCAGAATTCTATCTGTCCA 
                   
               
               
                   
                 AACAATCTGTACCACTCCACCTATATCCCTACCTTTGCATGTCTGTCCAA 
                   
               
               
                   
                 CCTCAAAGTCCAGGTCTATACACACGGGTAAGACTAGAGCAGTTCAAG 
                   
               
               
                   
                 TTTCAGAAAATGAGAAAGAGGAACTGAGTTGTGCTGAACCCATACAAA 
                   
               
               
                   
                 ATAAACACATTCTTTGTATAGATTCTTGGAACCTCGAGAGGAATTCACC 
                   
               
               
                   
                 TAACTCATAGGTATTTGATGGTATGAATCCATGGCTGGGCTCGGCTTTT 
                   
               
               
                   
                 AAAAAGCCTTATCTGGGATTCCTTCTATGGAACCAAGTTCCATCAAAGC 
                   
               
               
                   
                 CCATTTAAAAGCCTACATTAAAAACAAAATTCTTGCTGCATTGTATACA 
                   
               
               
                   
                 AATAATGATGTCATGATCAAATAATCAGATGCCATTATCAAGTGGAATT 
                   
               
               
                   
                 ACAAAATGGTATACCCACTCCAAAAAAAAAAAAAAAGCTAAATTCTCA 
                   
               
               
                   
                 GTAGAACATTGTGACTTCATGAGCCCTCCACAGCCTTGGAGCTGAGGAG 
                   
               
               
                   
                 GGAGCACTGGTGAGCAGTAGGTTGAAGAGAAAACTTGGCGCTTAATAA 
                   
               
               
                   
                 TCTATCCATGTTTTTTCATCTAAAAGAGCCTTCTTTTTGGATTACCTTATT 
                   
               
               
                   
                 CAATTTCCATCAAGGAAATTGTTAGTTCCACTAACCAGACAGCAGCTGG 
                   
               
               
                   
                 GAAGGCAGAAGCTTACTGTATGTACATGGTAGCTGTGGGAAGGAGGTT 
                   
               
               
                   
                 TCTTTCTCCAGGTCCTCACTGGCCATACACCAGTCCCTTGTTAGTTATGC 
                   
               
               
                   
                 CTGGTCATAGACCCCCGTTGCTATCATCTCATATTTAAGTCTTTGGCTTG 
                   
               
               
                   
                 TGAATTTATCTATTCTTTCAGCTTCAGCACTGCAGAGTGCTGGGACTTTG 
                   
               
               
                   
                 CTAACTTCCATTTCTTGCTGGCTTAGCACATTCCTCATAGGCCCAGCTCT 
                   
               
               
                   
                 TTTCTCATCTGGCCCTGCTGTGGAGTCACCTTGCCCCTTCAGGAGAGCC 
                   
               
               
                   
                 ATGGCTTACCACTGCCTGCTAAGCCTCCACTCAGCTGCCACCACACTAA 
                   
               
               
                   
                 ATCCAAGCTTCTCTAAGATGTTGCAGACTTTACAGGCAAGCATAAAAGG 
                   
               
               
                   
                 CTTGATCTTCCTGGACTTCCCTTTACTTGTCTGAATCTCACCTCCTTCAA 
                   
               
               
                   
                 CTTTCAGTCTCAGAATGTAGGCATTTGTCCTCTTTGCCCTACATCTTCCT 
                   
               
               
                   
                 TCTTCTGAATCATGAAAGCCTCTCACTTCCTCTTGCTATGTGCTGGAGGC 
                   
               
               
                   
                 TTCTGTCAGGTTTTAGAATGAGTTCTCATCTAGTCCTAGTAGCTTTTGAT 
                   
               
               
                   
                 GCTTAAGTCCACCTTTTAAGGATACCTTTGAGATTTAGACCATGTTTTTC 
                   
               
               
                   
                 GCTTGAGAAAGCCCTAATCTCCAGACTTGCCTTTCTGTGGATTTCAAAG 
                   
               
               
                   
                 ACCAACTGAGGAAGTCAAAAGCTGAATGTTGACTTTCTTTGAACATTTC 
                   
               
               
                   
                 CGCTATAACAATTCCAATTCTCCTCAGAGCAATATGCCTGCCTCCAACT 
                   
               
               
                   
                 GACCAGGAGAAAGGTCCAGTGCCAAAGAGAAAAACACAAAGATTAATT 
                   
               
               
                   
                 ATTTCAGTTGAGCACATACTTTCAAAGTGGTTTGGGTATTCATATGAGG 
                   
               
               
                   
                 TTTTCTGTCAAGAGGGTGAGACTCTTCATCTATCCATGTGTGCCTGACA 
                   
               
               
                   
                 GTTCTCCTGGCACTGGCTGGTAACAGATGCAAAACTGTAAAAATTAAGT 
                   
               
               
                   
                 GATCATGTATTTTAACGATATCATCACATACTTATTTTCTATGTAATGTT 
                   
               
               
                   
                 TTAAATTTCCCCTAACATACTTTGACTGTTTTGCACATGGTAGATATTCA 
                   
               
               
                   
                 CATTTTTTTGTGTTGAAGTTGATGCAATCTTCAAAGTTATCTACCCCGTT 
                   
               
               
                   
                 GCTTATTAGTAAAACTAGTGTTAATACTTGGCAAGAGATGCAGGGAATC 
                   
               
               
                   
                 TTTCTCATGACTCACGCCCTATTTAGTTATTAATGCTACTACCCTATTTT 
                   
               
               
                   
                 GAGTAAGTAGTAGGTCCCTAAGTACATTGTCCAGAGTTATACTTTTAAA 
                   
               
               
                   
                 GATATTTAGCCCCATATACTTCTTGAATCTAAAGTCATACACCTTGCTCC 
                   
               
               
                   
                 TCATTTCTGAGTGGGAAAGACATTTGAGAGTATGTTGACAATTGTTCTG 
                   
               
               
                   
                 AAGGTTTTTGCCAAGAAGGTGAAACTGTCCTTTCATCTGTGTATGCCTG 
                   
               
               
                   
                 GGGCTGGGTCCCTGGCAGTGATGGGGTGACAATGCAAAGCTGTAAAAA 
                   
               
               
                   
                 CTAGGTGCTAGTGGGCACCTAATATCATCATCATATACTTATTTTCAAG 
                   
               
               
                   
                 CTAATATGCAAAATCCCATCTCTGTTTTTAAACTAAGTGTAGATTTCAG 
                   
               
               
                   
                 AGAAAATATTTTGTGGTTCACATAAGAAAACAGTCTACTCAGCTTGACA 
                   
               
               
                   
                 AGTGTTTTATGTTAAATTGGCTGGTGGTTTGAAATGAATCATCTTCACAT 
                   
               
               
                   
                 AATGTTTTCTTTAAAAATATTGTGAATTTAACTCTAATTCTTGTTATTCT 
                   
               
               
                   
                 GTGTGATAATAAAGAATAAACTAATTTCTA 
                   
               
               
                   
               
               
                 AK093306 
                 ATTCTATGCTGCAGCCTAAGCATCATTCCTCTTCTCTTCTTAGTGGAGAT 
                 190 
               
               
                   
                 AAAATTACCCACTGCTCTCCTTACATTTACTTTGTCCATATTTGCTCCTA 
                   
               
               
                   
                 TGCTCTAGGCTCGTGCACAACAAACACAGTGTGGGCCCTTACCCTAGAA 
                   
               
               
                   
                 GCCAACTTCTCATGACCTTTCTCTATCTCCAGAATCCATGCAGTGGGAA 
                   
               
               
                   
                 TGAAGGTAAAAGAAGGTTTTCATGGGATCCAGCTGAGAGCTCTACGGG 
                   
               
               
                   
                 GAAAATGGATCTGAGGAGCCATGTGCTCCATCTCTTTTATTTTACAGGT 
                   
               
               
                   
                 AGAGACTAGGGGTATAGAGTGAGGTGAATTACCGCAGTGACCCACACA 
                   
               
               
                   
                 TTGTTGGCAGACCTAGGATTAGAACTCTGTCTTCCTGGTTCCCAGCTTGG 
                   
               
               
                   
                 TGCTTTTGAAAGCATACTTGCTGCTTTCTTACCGGCCTGGTGTCTGCCAC 
                   
               
               
                   
                 TTTGGGACAGAGTGTGGACTTGCTCACCTGCCCCATTTCTTAGGGATTCT 
                   
               
               
                   
                 CATTCTGTGTTTGAGCAAGAATATTCTTATTCTGGAAAGAACCACATAC 
                   
               
               
                   
                 CACAGGATTCTGGGTGAGCATAAGGAAGATTGTCTTGGGGATCTGACTT 
                   
               
               
                   
                 AGCTCACGTATAGTGGCTATGATGAATTCAGTGTCTTATTTTTTGCATAT 
                   
               
               
                   
                 GTATATTTTTAGTCTAATATTGCCTGGGTGTCTGAGCAAGTCTAGATGA 
                   
               
               
                   
                 ATTTAATTGCTCTCATTTTTCCCCTGCCCCTCTTCCTTTGGTCTCTCTTTT 
                   
               
               
                   
                 AGGAAATGTTTTTCTTTCAACATTCGTTTCATTCATTATTTACTCATTCG 
                   
               
               
                   
                 GCCAACCAACATTTATTGAGTGCCTTCCCTGTATCAGGGACAGGGGCTT 
                   
               
               
                   
                 ACAAAGTAGAATTTGATCCCACCTCTGCCCTCAGTAGCTCAGTGTCTAA 
                   
               
               
                   
                 TGGAGGTAGTGATGTTCATTAAGCGTCGCCAGATACTGTGCTAGGTGCT 
                   
               
               
                   
                 GTGCCTGTTCTCTCTCGCTTGTTCCTCACACACTTGAGAAGGCCGAAGCT 
                   
               
               
                   
                 GATTCATAGCTTGGAAGGCAGGGGCCTTGGATTTGAACCCAGGCCTGAC 
                   
               
               
                   
                 CAATGGCAGAACCTATCAGATGTGTGGACAGATGACATTGCCTTTCTTT 
                   
               
               
                   
                 CTTTGGATATATCAAAATCAGCCAGCAGGCAGGAACTCCCATTTTGAGC 
                   
               
               
                   
                 AAGCAATGTGCAGGAATGATAGGGTATACAGAGAGGAACAGGAGATG 
                   
               
               
                   
                 GCCCCTGACTTCCAGCATGTGTCTGATGGACATCCAGGCTGCAGGCATC 
                   
               
               
                   
                 ATGGTGCTGTCTAGAGAGATGAGCCAGGTGCCCAGAGCCCATGGGCCA 
                   
               
               
                   
                 ATGCTGCCCTTTCTTGAGCATGCCAAACAAAGCGGTTGGTGTGTTAGAG 
                   
               
               
                   
                 GCACAGTCTCCTCCACTCTAAGTAAAAATCAGCATGAGTCCTAGCCCAC 
                   
               
               
                   
                 ATTTCCCTAGTGAGTACACCAAAGATATCTATGAACTGGCAGTCATCAG 
                   
               
               
                   
                 TGACTTCCTAAGGTTCCGGAAATGCATCTCTTACTCAGGAGTAAGCAAT 
                   
               
               
                   
                 GATGTGCCTGCGGCTTTACGAGTTCTCACAGAATGACTTTCTGGACCCA 
                   
               
               
                   
                 AATGTTTTTTCTGCTTCAGGACTGTGAAGGCCTTATTGTTCGCTCTGCCA 
                   
               
               
                   
                 CCAAGGTGACCGCTGATGTCATCAACGCAGCTGAGAAACTCCAGGTGG 
                   
               
               
                   
                 TGGGCAGGGCTGGCACAGGTGTGGACAATGTGGATCTGGAGGCCGCAA 
                   
               
               
                   
                 CAAGGAAGGGCATCTTGGTTATGAACACCCCCAATGGGAACAGCCTCA 
                   
               
               
                   
                 GTGCCGCAGAACTCACTTGTGGAATGATCATGTGCCTGGCCAGGCAGAT 
                   
               
               
                   
                 TCCCCAGGCGACGGCTTCGATGAAGGACGGCAAATGGGAGCGGAAGAA 
                   
               
               
                   
                 GTTCATGGGAACAGAGCTGAATGGAAAGACCCTGGGAATTCTTGGCCT 
                   
               
               
                   
                 GGGCAGGATTGGGAGAGAGGTAGCTACCCGGATGCAGTCCTTTGGGAT 
                   
               
               
                   
                 GAAGACTATAGGGTATGACCCCATCATTTCCCCAGAGGTCTCGGCCTCC 
                   
               
               
                   
                 TTTGGTGTTCAGCAGCTGCCCCTGGAGGAGATCTGGCCTCTCTGTGATTT 
                   
               
               
                   
                 CATCACTGTGCACACTCCTCTCCTGCCCTCCACGACAGGCTTGCTGAAT 
                   
               
               
                   
                 GACAACACCTTTGCCCAGTGCAAGAAGGGGGTGCGTGTGGTGAACTGT 
                   
               
               
                   
                 GCCCGTGGAGGGATCGTGGACGAAGGCGCCCTGCTCCGGGCCCTGCAG 
                   
               
               
                   
                 TCTGGCCAGTGTGCCGGGGCTGCACTGGACGTGTTTACGGAAGAGCCGC 
                   
               
               
                   
                 CACGGGACCGGGCCTTGGTGGACCATGAGAATGTCATCAGCTGTCCCCA 
                   
               
               
                   
                 CCTGGGTGCCAGCACCAAGGAGGCTCAGAGCCGCTGTGGGGAGGAAAT 
                   
               
               
                   
                 TGCTGTTCAGTTCGTGGACATGGTGAAGGGGAAATCTCTCACGGGGGTT 
                   
               
               
                   
                 GTGAATGCCCAGGCCCTTACCAGTGCCTTCTCTCCACACACCAAGCCTT 
                   
               
               
                   
                 GGATTGGTCTGGCAGAAGCTCTGGGGACACTGATGCGAGCCTGGGCTG 
                   
               
               
                   
                 GGTCCCCCAAAGGGACCATCCAGGTGATAACACAGGGAACATCCCTGA 
                   
               
               
                   
                 AGAATGCTGGGAACTGCCTAAGCCCCGCAGTCATTGTCGGCCTCCTGAA 
                   
               
               
                   
                 AGAGGCTTCCAAGCAGGCGGATGTGAACTTGGTGAACGCTAAGCTGCT 
                   
               
               
                   
                 GGTGAAAGAGGCTGGCCTCAATGTCACCACCTCCCACAGCCCTGCTGCA 
                   
               
               
                   
                 CCAGGGGGGCAAGGCTTCGGGGAATGCCTCCTGGCCGTGGCCCTGGCA 
                   
               
               
                   
                 GGCGCCCCTTACCAGGCTGTGGGCTTGGTCCAAGGCACTACACCTGTAC 
                   
               
               
                   
                 TGCAGGGGCTCAATGGAGCTGTCTTCAGGCCAGAAGTGCCTCTCCGCAG 
                   
               
               
                   
                 GGACCTGCCCCTGCTCCTATTCCGGACTCAGACCTCTGACCCTGCAATG 
                   
               
               
                   
                 CTGCCTACCATGATTGGCCTCCTGGCAGAGGCAGGCGTGCGGCTGCTGT 
                   
               
               
                   
                 CCTACCAGACTTCACTGGTGTCAGATGGGGAGACCTGGCACGTCATGGG 
                   
               
               
                   
                 CATCTCCTCCTTGCTGCCCAGCCTGGAAGCGTGGAAGCAGCATGTGACT 
                   
               
               
                   
                 GAAGCCTTCCAGTTCCACTTCTAACCTTGGAGCTCACTGGTCCCTGCCTC 
                   
               
               
                   
                 TGGGGCTTTTCTGAAGAAACCCACCCACTGTGATCAATAGGGAGAGAA 
                   
               
               
                   
                 AATCCACATTCTTGGGCTGAACGCGAGCCTCTGACACTGCTTACACTGC 
                   
               
               
                   
                 ACTCTGACCCTGTAGTACAGCAATAACCGTCTAATAAAGAGCCTACCCC 
                   
               
               
                   
                 C 
                   
               
               
                   
               
               
                 BE904476 
                 CAAACAAAAACAGCCAAGCTTTTCTGCCAAAAAGATGACTGAGAAGAC 
                 191 
               
               
                   
                 TGTTAAAGCAAAAAGCTCTGTTCCTGCCTCAGATGATGCCTATCCAGAA 
                   
               
               
                   
                 ATAGAAAAATTCTTTCCCTTCAATCCTCTAGACTTTGAGAGTTTTGACCT 
                   
               
               
                   
                 GCCTGAAGAGCACCAGATTGCGCACCTCCCCTTGAGTGGAGTGCCTCTC 
                   
               
               
                   
                 ATGATCCTTGACGAGGAGAGAGAGCTTGAAAAGCTGTTTCAGCTGGGC 
                   
               
               
                   
                 CCCCCTTCACCTGTGAAGATGCCCTCTCCACCATGGGAATCCAATCTGT 
                   
               
               
                   
                 TGCAGTCTCCTTCAAGCATTCTGTCGACCCTGGATGTTGAATTGCCACCT 
                   
               
               
                   
                 GTTTGCTGTGACATAGATATTTAAATTTCTTAGTGCTTCAGAGTCTGTGT 
                   
               
               
                   
                 GTATTTGTATTAATAAAGCATTCTTTAACAGAAAAAAAAAAAAAAAAA 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGGGGGGGAGACACAA 
                   
               
               
                   
                 AAAGAATTCCCCAAGAGGGGGCCACAAGATAATCAGAGGATATCACAC 
                   
               
               
                   
                 AAGATCTCTCGGCGCACCAACGACGGGGGCCCCAAATAAGGGAGAGAC 
                   
               
               
                   
                 CCAGAATCACAACAGCCAAGACACGGTGGACACGACGGAAACAAACA 
                   
               
               
                   
                 CACAGCCCAGACACGGGGGCAAACACGCGCGCACACCGCGGACACCAT 
                   
               
               
                   
                 GGGACAAAGCAGACACCACCCACAAAACAACACCGCGGAGGGGGAAG 
                   
               
               
                   
                 AACAACAAAACAAGTGCGCAAACAGAACACAACCACAGAAAGAGAAA 
                   
               
               
                   
                 AATTAAAACGGCCCCCAAGACGGCGACAACACAACAAAACAACCACTA 
                   
               
               
                   
                 CAGAGCGCTCAACAGCCGAGTAAAAACACAACAACGGACAACTAACAC 
                   
               
               
                   
                 ACAAAGGAATGAAACAAAGCGGGGCCACACACCGACACCGGAAATCC 
                   
               
               
                   
                 GGCGAACAACTCACACCGAGCGAGGGTCCCAGACAACAAATACACAGA 
                   
               
               
                   
                 CAACGAAACCGAGAAACAAGACCAGCAAGACGAGCAGGCAAAAGACA 
                   
               
               
                   
                 AACAAGACAGAGGAGACGACGACGAACGCAAAGGACAAGAGGACACA 
                   
               
               
                   
                 ACGACGCGAGGAGCGAGAGCGAGAGGAAGAGACAACAAAAAGACACA 
                   
               
               
                   
                 AAAGAACAACAAGCAAGCAGCGAAGAACGACACACAACCACACGAGA 
                   
               
               
                   
                 CAGCAGGAGCAGAGGCGGAGAAAACACAACGAGCAAGCCAAGACCAA 
                   
               
               
                   
                 GAGAGGAGAACAAAATAAAAAAATACGAGAGCAGGCGGACGAGAGCA 
                   
               
               
                   
                 CGAGACGAACAGACAAACGGGAATCAGAAGCATAACGATCCGCGACG 
                   
               
               
                   
                 CGAACAACN 
                   
               
               
                   
               
               
                 AK123010 
                 GTGCACCCTGTCCCAGCCGTCCTGTCCTGGCTGCTCGCTCTGCTTCGCTG 
                 192 
               
               
                   
                 CGCCTCCACTATGCTCTCCCTCCGTGTCCCGCTCGCGCCCATCACGGACC 
                   
               
               
                   
                 CGCAGCAGCTGCAGCTCTCGCCGCTGAAGGGGCTCAGCTTGGTCGACA 
                   
               
               
                   
                 AGGAGAACACGCCGCCGGCCCTGAGCGGGACCCGCGTCCTGGCCAGCA 
                   
               
               
                   
                 AGACCGCGAGGAGGATCTTCCAGGAGAAAACCCCCGCCGCTTTGTCAT 
                   
               
               
                   
                 CTTCCCCATCGAGTACCATGATATCTGGCAGATGTATAAGAAGGCAGAG 
                   
               
               
                   
                 GCTTCCTTTTGGACCGCCGAGGAGGTGGACCTCTCCAAGGACATTCAGC 
                   
               
               
                   
                 ACTGGGAATCCCTGAAACCCGAGGAGAGATATTTTATATCCCATGTTCT 
                   
               
               
                   
                 GGCTTTCTTTGCAGCAAGCGATGGCATAGTAAATGAAAACTTGGTGGAG 
                   
               
               
                   
                 CGATTTAGCCAAGAAGTTCAGATTACAGAAGCCCGCTGTTTCTATGGCT 
                   
               
               
                   
                 TCCAAATTGCCATGGAAAACATACATTCTGAAATGTATAGTCTTCTTAT 
                   
               
               
                   
                 TGACACTTACATAAAAGATCCCAAAGAAAGGGAATTTCTCTTCAATGCC 
                   
               
               
                   
                 ATTGAAACGATGCCTTGTGTCAAGAAGAAGGCAGACTGGGCCTTGCGC 
                   
               
               
                   
                 TGGATTGGGGACAAAGAGGCTACCTATGGTGAACGTGTTGTAGCCTTTG 
                   
               
               
                   
                 CTGCAGTGGAAGGCATTTTCTTTTCCGGTTCTTTTGCGTCGATATTCTGG 
                   
               
               
                   
                 CTCAAGAAACGAGGACTGATGCCTGGCCTCACATTTTCTAATGAACTTA 
                   
               
               
                   
                 TTAGCAGAGATGAGGGTTTACACTGTGATTTTGCTTGCCTGATGTTCAA 
                   
               
               
                   
                 ACACCTGGTACACAAACCATCGGAGGAGAGAGTAAGAGAAATAATTAT 
                   
               
               
                   
                 CAATGCTGTTCGGATAGAACAGGAGTTCCTCACTGAGGCCTTGCCTGTG 
                   
               
               
                   
                 AAGCTCATTGGGATGAATTGCACTCTAATGAAGCAATACATTGAGTTTG 
                   
               
               
                   
                 TGGCAGACAGACTTATGCTGGAACTGGGTTTTAGCAAGGTTTTCAGAGT 
                   
               
               
                   
                 AGAGAACCCATTTGACTTTATGGAGAATATTTCACTGGAAGGAAAGACT 
                   
               
               
                   
                 AACTTCTTTGAGAAGAGAGTAGGCGAGTATCAGAGGATGGGAGTGATG 
                   
               
               
                   
                 TCAAGTCCAACAGAGAATTCTTTTACCTTGGATGCTGACTTCTAAATGA 
                   
               
               
                   
                 ACTGAAGATGTGCCCTTACTTGGCTGATTTTTTTTTTTCCATCTCATAAG 
                   
               
               
                   
                 AAAAATCAGCTGAAGTGTTACCAACTAGCCACACCATGAATTGTCCGTA 
                   
               
               
                   
                 ATGTTCATTAACAGCATCTTTAAAACTGTGTAGCTACCTCACAACCAGT 
                   
               
               
                   
                 CCTGTCTGTTTATAGTGCTGGTAGTATCACCTTTTGCCAGAAGGCCTGGC 
                   
               
               
                   
                 TGGCTGTGACTTACCATAGCAGTGACAATGGCAGTCTTGGCTTTAAAGT 
                   
               
               
                   
                 GAGGGGTGACCCTTTAGTGAGCTTAGCACAGCGGGATTAAACAGTCCTT 
                   
               
               
                   
                 TAACCAGCACAGCCAGTTAAAAGATGCAGCCTCACTGCTTCAACGCAG 
                   
               
               
                   
                 ATTTTAATGTTTACTTAAATATAAACCTGGCACTTTACAAACAAATAAA 
                   
               
               
                   
                 CATTGTTTGTACTCACAAGGCGATAATAGCTTGATTTATTTGGTTTCTAC 
                   
               
               
                   
                 ACCAAATACATTCTCCTGACCACTAATGGGAGCCAATTCACAATTCACT 
                   
               
               
                   
                 AAGTGACTAAAGTAAGTTAAACTTGTGTAGACTAAGCATGTAATTTTTA 
                   
               
               
                   
                 AGTTTTATTTTAATGAATTAAAATATTTGTTAACCAACTTTAAAGTCAGT 
                   
               
               
                   
                 CCTGTGTATACCTAGATATTAGTCAGTTGGTGCCAGATAGAAGACAGGT 
                   
               
               
                   
                 TGTGTTTTTATCCTGTGGCTTGTGTAGTGTCCTGGGATTCTCTGCCCCCT 
                   
               
               
                   
                 CTGAGTAGAGTGTTGTGGGATAAAGGAATCTCTCAGGGCAAGGAGCTT 
                   
               
               
                   
                 CTTAAGTTAAATCACTAGAAATTTAGGGGTGATCTGGGCCTTCATATGT 
                   
               
               
                   
                 GTGAGAAGCCGTTTCATTTTATTTCTCACTGTATTTTCCTCAACGTCTGG 
                   
               
               
                   
                 TTGATGAGAAAAAATTCTTGAAGAGTTTTCATATGTGGGAGCTAAGGTA 
                   
               
               
                   
                 GTATTGTAAAATTTCAAGTCATCCTTAAACAAAATGATCCACCTAAGAT 
                   
               
               
                   
                 CTTGCCCCTGTTAAGTGGTGAAATCAACTAGAGGTGGTTCCTACAAGTT 
                   
               
               
                   
                 GTTCATTCTAGTTTTGTTTGGTGTAAGTAGGTTGTGTGAGTTAATTCATT 
                   
               
               
                   
                 TATATTTACTATGTCTGTTAAATCAGAAATTTTTTATTATCTATGTTCTTC 
                   
               
               
                   
                 TAGATTTTACCTGTAGTTCATACTTCAGTCACCCAGTGTCTTATTCTGGC 
                   
               
               
                   
                 ATTGTCTAAATCTGAGCATTGTCTAGGGGGATCTTAAACTTTAGTAGGA 
                   
               
               
                   
                 AACCATGAGCTGTTAATACAGTTTCCATTCAAATATTAATTTCAGAATG 
                   
               
               
                   
                 AAACATAATTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCC 
                   
               
               
                   
                 AGGCTGGAGTGCAGTGGCGCGATTTTGGCTCACTGTAACCTCCATCTCC 
                   
               
               
                   
                 TGGGTTCAAGCAATTCTCCTGTCTCAGCCTCCCTAGTAGCTGGGACTGC 
                   
               
               
                   
                 AGGTATGTGCTACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATG 
                   
               
               
                   
                 GAGTTTCACCATATTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTG 
                   
               
               
                   
                 ATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTGCAGGCGTGATAAA 
                   
               
               
                   
                 CAAATATTCTTAATAGGGCTACTTTGAATTAATCTGCCTTTATGTTTGGG 
                   
               
               
                   
                 AGAAGAAAGCTGAGACATTGCATGAAAGATGATGAGAGATAAATGTTG 
                   
               
               
                   
                 ATCTTTTGGCCCCATTTGTTAATTGTATTCAGTATTTGAACGTCGTCCTG 
                   
               
               
                   
                 TTTATTGTTAGTTTTCTTCATCATTTATTGTATAGACAATTTTTAAATCTC 
                   
               
               
                   
                 TGTAATATGATACATTTTCCTATCTTTTAAGTTATTGTTACCTAAAGTTA 
                   
               
               
                   
                 ATCCAGATTATATGGTCCTTATATGTGTACAACATTAAAATGAAAGGCT 
                   
               
               
                   
                 TTGTCTTGCATTGTGAGGTACAGGCGGAAGTTGGAATCAGGTTTTAGGA 
                   
               
               
                   
                 TTCTGTCTCTCATTAGCTGAATAATGTGAGGATTAACTTCTGCCAGCTCA 
                   
               
               
                   
                 GACCATTTCCTAATCAGTTGAAAGGGAAACAAGTATTTCAGTCTCAAAA 
                   
               
               
                   
                 TTGAATAATGCACAAGTCTTAAGTGATTAAAATAAAACTGTTCTTATGT 
                   
               
               
                   
                 CAGTTT 
                   
               
               
                   
               
               
                 BC036503 
                 AGCGGGGGCACTCCAGCCCTGCAGCCTCCGGAGTCAGTGCCGCGCGCC 
                 193 
               
               
                   
                 CGCCGCCCCGCGCCTTCCTGCTCGCCGCACCTCCGGGAGCCGGGGCGCA 
                   
               
               
                   
                 CCCAGCCCGCAGCGCCGCCTCCCCGCCCGCGCCGCCTCCGACCGCAGGC 
                   
               
               
                   
                 CGAGGGCCGCCACTGGCCGGGGGGACCGGGCAGCAGCTTGCGGCCGCG 
                   
               
               
                   
                 GAGCCGGGCAACGCTGGGGACTGCGCCTTTTGTCCCCGGAGGTCCCTGG 
                   
               
               
                   
                 AAGTTTGCGGCAGGACGCGCGCGGGGAGGCGGCGGAGGCAGCCCCGAC 
                   
               
               
                   
                 GTCGCGGAGAACAGGGCGCAGAGCCGGCATGGGCATCGGGCGCAGCG 
                   
               
               
                   
                 AGGGGGGCCGCCGCGGGGCAGCCCTGGGCGTGCTGCTGGCGCTGGGCG 
                   
               
               
                   
                 CGGCGCTTCTGGCCGTGGGCTCGGCCAGCGAGTACGACTACGTGAGCTT 
                   
               
               
                   
                 CCAGTCGGACATCGGCCCGTACCAGAGCGGGCGCTTCTACACCAAGCC 
                   
               
               
                   
                 ACCTCAGTGCGTGGACATCCCCGCGGACCTGCGGCTGTGCCACAACGTG 
                   
               
               
                   
                 GGCTACAAGAAGATGGTGCTGCCCAACCTGCTGGAGCACGAGACCATG 
                   
               
               
                   
                 GCGGAGGTGAAGCAGCAGGCCAGCAGCTGGGTGCCCCTGCTCAACAAG 
                   
               
               
                   
                 AACTGCCACGCCGGCACCCAGGTCTTCCTCTGCTCGCTCTTCGCGCCCG 
                   
               
               
                   
                 TCTGCCTGGACCGGCCCATCTACCCGTGTCGCTGGCTCTGCGAGGCCGT 
                   
               
               
                   
                 GCGCGACTCGTGCGAGCCGGTCATGCAGTTCTTCGGCTTCTACTGGCCC 
                   
               
               
                   
                 GAGATGCTTAAGTGTGACAAGTTCCCCGAGGGGGACGTCTGCATCGCC 
                   
               
               
                   
                 ATGACGCCGCCCAATGCCACCGAAGCCTCCAAGCCCCAAGGCACAACG 
                   
               
               
                   
                 GTGTGTCCTCCCTGTGACAACGAGTTGAAATCTGAGGCCATCATTGAAC 
                   
               
               
                   
                 ATCTCTGTGCCAGCGAGTTTGCACTGAGGATGAAAATAAAAGAAGTGA 
                   
               
               
                   
                 AAAAAGAAAATGGCGACAAGAAGATTGTCCCCAAGAAGAAGAAGCCC 
                   
               
               
                   
                 CTGAAGTTGGGGCCCATCAAGAAGAAGGACCTGAAGAAGCTTGTGCTG 
                   
               
               
                   
                 TACCTGAAGAATGGGGCTGACTGTCCCTGCCACCAGCTGGACAACCTCA 
                   
               
               
                   
                 GCCACCACTTCCTCATCATGGGCCGCAAGGTGAAGAGCCAGTACTTGCT 
                   
               
               
                   
                 GACGGCCATCCACAAGTGGGACAAGAAAAACAAGGAGTTCAAAAACTT 
                   
               
               
                   
                 CATGAAGAAAATGAAAAACCATGAGTGCCCCACCTTTCAGTCCGTGTTT 
                   
               
               
                   
                 AAGTGATTCTCCCGGGGGCAGGGTGGGGAGGGAGCCTCGGGTGGGGTG 
                   
               
               
                   
                 GGAGCGGGGGGGACAGTGCCCCGGGAACCCGGTGGGTCACACACACGC 
                   
               
               
                   
                 ACTGCGCCTGTCAGTAGTGGACATTTAATCCAGTCGGCTTGTTCTTGCA 
                   
               
               
                   
                 GCATTCCCGCTCCCTTCCCTCCATAGCCACGCTCCAAACCCCAGGGTAG 
                   
               
               
                   
                 CCATGGCCGGGTAAAGCAAGGGCCATTTAGATTAGGAAGGTTTTTAAG 
                   
               
               
                   
                 ATCCGCAATGTGGAGCAGCAGCCACTGCACAGGAGGAGGTGACAAACC 
                   
               
               
                   
                 ATTTCCAACAGCAACACAGCCACTAAAACACAAAAAGGGGGATTGGGC 
                   
               
               
                   
                 GGAAAGTGAGAGCCAGCAGCAAAAACTACATTTTGCAACTTGTTGGTG 
                   
               
               
                   
                 TGGATCTATTGGCTGATCTATGCCTTTCAACTAGAAAATTCTAATGATTG 
                   
               
               
                   
                 GCAAGTCACGTTGTTTTCAGGTCCAGAGTAGTTTCTTTCTGTCTGCTTTA 
                   
               
               
                   
                 AATGGAAACAGACTCATACCACACTTACAATTAAGGTCAAGCCCAGAA 
                   
               
               
                   
                 AGTGATAAGTGCAGGGAGGAAAAGTGCAAGTCCATTATGTAATAGTGA 
                   
               
               
                   
                 CAGCAAAGGGACCAGGGGAGAGGCATTGCCTTCTCTGCCCACAGTCTTT 
                   
               
               
                   
                 CCGTGTGATTGTCTTTGAATCTGAATCAGCCAGTCTCAGATGCCCCAAA 
                   
               
               
                   
                 GTTTCGGTTCCTATGAGCCCGGGGCATGATCTGATCCCCAAGACATGTG 
                   
               
               
                   
                 GAGGGGCAGCCTGTGCCTGCCTTTGTGTCAGAAAAAGGAAACCACAGT 
                   
               
               
                   
                 GAGCCTGAGAGAGACGGCGATTTTCGGGCTGAGAAGGCAGTAGTTTTC 
                   
               
               
                   
                 AAAACACATAGTTAAAAAAGAAACAAATGAAAAAAATTTTAGAACAGT 
                   
               
               
                   
                 CCAGCAAATTGCTAGTCAGGGTGAATTGTGAAATTGGGTGAAGAGCTT 
                   
               
               
                   
                 ACGATTCTAATCTCATGTTTTTTCCTTTTCACATTTTTAAAAGAACAATG 
                   
               
               
                   
                 ACAAACACCCACTTATTTTTCAAGGTTTTAAAACAGTCTACATTGAGCA 
                   
               
               
                   
                 TTTGAAAGGTGTGCTAGAACAAGGTCTCCTGATCCGTCCGAGGCTGCTT 
                   
               
               
                   
                 CCCAGAGGAGCAGCTCTCCCCAGGCATTTGCCAAGGGAGGCGGATTTC 
                   
               
               
                   
                 CCTGGTAGTGTAGCTGTGTGGCTTTCCTTCCTGAAGAGTCCGTGGTTGCC 
                   
               
               
                   
                 CTAGAACCTAACACCCCCTAGCAAAACTCACAGAGCTTTCCGTTTTTTT 
                   
               
               
                   
                 CTTTCCTGTAAAGAAACATTTCCTTTGAACTTGATTGCCTATGGATCAAA 
                   
               
               
                   
                 GAAATTCAGAACAGCCTGCCTGTCCCCCCGCACTTTTTACATATATTTGT 
                   
               
               
                   
                 TTCATTTCTGCAGATGGAAAGTTGACATGGGTGGGGTGTCCCCATCCAG 
                   
               
               
                   
                 CGAGAGAGTTTAAAAAGCAAAACATCTCTGCAGTTTTTCCCAAGTGCCC 
                   
               
               
                   
                 TGAGATACTTCCCAAAGCCCTTATGTTTAATCAGCGATGTATATAAGCC 
                   
               
               
                   
                 AGTTCACTTAGACAACTTTACCCTTCTTGTCCAATGTACAGGAAGTAGT 
                   
               
               
                   
                 TCTAAAAAAAATGCATATTAATTTCTTCCCCCAAAGCCGGATTCTTAAT 
                   
               
               
                   
                 TCTCTGCAACACTTTGAGGACATTTATGATTGTCCCTCTGGGCCAATGCT 
                   
               
               
                   
                 TATACCCAGTGAGGATGCTGCAGTGAGGCTGTAAAGTGGCCCCCTGCG 
                   
               
               
                   
                 GCCCTAGCCTGACCCGGAGGAAAGGATGGTAGATTCTGTTAACTCTTGA 
                   
               
               
                   
                 AGACTCCAGTATGAAAATCAGCATGCCCGCCTAGTTACCTACCGGAGA 
                   
               
               
                   
                 GTTATCCTGATAAATTAACCTCTCACAGTTAGTGATCCTGTCCTTTTAAC 
                   
               
               
                   
                 ACCTTTTTTGTGGGGTTCTCTCTGACCTTTCATCGTAAAGTGCTGGGGAC 
                   
               
               
                   
                 CTTAAGTGATTTGCCTGTAATTTTGGATGATTAAAAAATGTGTATATAT 
                   
               
               
                   
                 ATTAGCTAATTAGAAATATTCTACTTCTCTGTTGTCAAACTGAAATTCAG 
                   
               
               
                   
                 AGCAAGTTCCTGAGTGCGTGGATCTGGGTCTTAGTTCTGGTTGATTCAC 
                   
               
               
                   
                 TCAAGAGTTCAGTGCTCATACGTATCTGCTCATTTTGACAAAGTGCCTC 
                   
               
               
                   
                 ATGCAACCGGGCCCTCTCTCTGCGGCAGAGTCCTTAGTGGAGGGGTTTA 
                   
               
               
                   
                 CCTGGAACATTAGTAGTTACCACAGAATACGGAAGAGCAGGTGACTGT 
                   
               
               
                   
                 GCTGTGCAGCTCTCTAAATGGGAATTCTCAGGTAGGAAGCAACAGCTTC 
                   
               
               
                   
                 AGAAAGAGCTCAAAATAAATTGGAAATGTGAATCGCAGCTGTGGGTTT 
                   
               
               
                   
                 TACCACCGTCTGTCTCAGAGTCCCAGGACCTTGAGTGTCATTAGTTACTT 
                   
               
               
                   
                 TATTGAAGGTTTTAGACCCATAGCAGCTTTGTCTCTGTCACATCAGCAA 
                   
               
               
                   
                 TTTCAGAACCAAAAGGGAGGCTCTCTGTAGGCACAGAGCTGCACTATC 
                   
               
               
                   
                 ACGAGCCTTTGTTTTTCTCCACAAAGTATCTAACAAAACCAATGTGCAG 
                   
               
               
                   
                 ACTGATTGGCCTGGTCATTGGTCTCCGAGAGAGGAGGTTTGCCTGTGAT 
                   
               
               
                   
                 TTCCTAATTATCGCTAGGGCCAAGGTGGGATTTGTAAAGCTTTACAATA 
                   
               
               
                   
                 ATCATTCTGGATAGAGTCCTGGGAGGTCCTTGGCAGAACTCAGTTAAAT 
                   
               
               
                   
                 CTTTGAAGAATATTTGTAGTTATCTTAGAAGATAGCATGGGAGGTGAGG 
                   
               
               
                   
                 ATTCCAAAAACATTTTATTTTTAAAATATCCTGTGTAACACTTGGCTCTT 
                   
               
               
                   
                 GGTACCTGTGGGTTAGCATCAAGTTCTCCCCAGGGTAGAATTCAATCAG 
                   
               
               
                   
                 AGCTCCAGTTTGCATTTGGATGTGTAAATTACAGTAATCCCATTTCCCA 
                   
               
               
                   
                 AACCTAAAATCTGTTTTTCTCATCAGACTCTGAGTAACTGGTTGCTGTGT 
                   
               
               
                   
                 CATAACTTCATAGATGCAGGAGGCTCAGGTGATCTGTTTGAGCAGAGCA 
                   
               
               
                   
                 CCCTAGGCAGCCTGCAGGGAATAACATACTGGCCGTTCTGACCTGTTGC 
                   
               
               
                   
                 CAGCAGATACACAGGACATGGATGAAATTCCCGTTTCCTCTAGTTTCTT 
                   
               
               
                   
                 CCTGTAGTACTCCTCTTTTAGATCCTAAGTCTCTTACAAAAGCTTTGAAT 
                   
               
               
                   
                 ACTGTGAAAATGTTTTACATTCCATTTCATTTGTGTTGTTTTTTTAACTGC 
                   
               
               
                   
                 ATTTTACCAGATGTTTTGATGTTATCGCTTATGTTAATAGTAATTCCCGT 
                   
               
               
                   
                 ACGTGTTCATTTTATTTTCATGCTTTTTCAGCCATGTATCAATATTCACTT 
                   
               
               
                   
                 GACTAAAATCACTCAATTAATCAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NM_012319 
                 AGTCCTGGGCGAAGGGGGCGGTGGTTCCCCGCGGCGCTGCGCGCGGCG 
                 194 
               
               
                   
                 GTAATTAGTGATTGTCTTCCAGCTTCGCGAAGGCTAGGGGCGCGGCTGC 
                   
               
               
                   
                 CGGGTGGCTGCGCGGCGCTGCCCCCGGACCGAGGGGCAGCCAACCCAA 
                   
               
               
                   
                 TGAAACCACCGCGTGTTCGCGCCTGGTAGAGATTTCTCGAAGACACCAG 
                   
               
               
                   
                 TGGGCCCGTTCCGAGCCCTCTGGACCGCCCGTGTGGAACCAAACCTGCG 
                   
               
               
                   
                 CGCGTGGCCGGGCCGTGGGACAACGAGGCCGCGGAGACGAAGGCGCA 
                   
               
               
                   
                 ATGGCGAGGAAGTTATCTGTAATCTTGATCCTGACCTTTGCCCTCTCTGT 
                   
               
               
                   
                 CACAAATCCCCTTCATGAACTAAAAGCAGCTGCTTTCCCCCAGACCACT 
                   
               
               
                   
                 GAGAAAATTAGTCCGAATTGGGAATCTGGCATTAATGTTGACTTGGCAA 
                   
               
               
                   
                 TTTCCACACGGCAATATCATCTACAACAGCTTTTCTACCGCTATGGAGA 
                   
               
               
                   
                 AAATAATTCTTTGTCAGTTGAAGGGTTCAGAAAATTACTTCAAAATATA 
                   
               
               
                   
                 GGCATAGATAAGATTAAAAGAATCCATATACACCATGACCACGACCAT 
                   
               
               
                   
                 CACTCAGACCACGAGCATCACTCAGACCATGAGCGTCACTCAGACCAT 
                   
               
               
                   
                 GAGCATCACTCAGACCACGAGCATCACTCTGACCATGATCATCACTCTC 
                   
               
               
                   
                 ACCATAATCATGCTGCTTCTGGTAAAAATAAGCGAAAAGCTCTTTGCCC 
                   
               
               
                   
                 AGACCATGACTCAGATAGTTCAGGTAAAGATCCTAGAAACAGCCAGGG 
                   
               
               
                   
                 GAAAGGAGCTCACCGACCAGAACATGCCAGTGGTAGAAGGAATGTCAA 
                   
               
               
                   
                 GGACAGTGTTAGTGCTAGTGAAGTGACCTCAACTGTGTACAACACTGTC 
                   
               
               
                   
                 TCTGAAGGAACTCACTTTCTAGAGACAATAGAGACTCCAAGACCTGGA 
                   
               
               
                   
                 AAACTCTTCCCCAAAGATGTAAGCAGCTCCACTCCACCCAGTGTCACAT 
                   
               
               
                   
                 CAAAGAGCCGGGTGAGCCGGCTGGCTGGTAGGAAAACAAATGAATCTG 
                   
               
               
                   
                 TGAGTGAGCCCCGAAAAGGCTTTATGTATTCCAGAAACACAAATGAAA 
                   
               
               
                   
                 ATCCTCAGGAGTGTTTCAATGCATCAAAGCTACTGACATCTCATGGCAT 
                   
               
               
                   
                 GGGCATCCAGGTTCCGCTGAATGCAACAGAGTTCAACTATCTCTGTCCA 
                   
               
               
                   
                 GCCATCATCAACCAAATTGATGCTAGATCTTGTCTGATTCATACAAGTG 
                   
               
               
                   
                 AAAAGAAGGCTGAAATCCCTCCAAAGACCTATTCATTACAAATAGCCT 
                   
               
               
                   
                 GGGTTGGTGGTTTTATAGCCATTTCCATCATCAGTTTCCTGTCTCTGCTG 
                   
               
               
                   
                 GGGGTTATCTTAGTGCCTCTCATGAATCGGGTGTTTTTCAAATTTCTCCT 
                   
               
               
                   
                 GAGTTTCCTTGTGGCACTGGCCGTTGGGACTTTGAGTGGTGATGCTTTTT 
                   
               
               
                   
                 TACACCTTCTTCCACATTCTCATGCAAGTCACCACCATAGTCATAGCCAT 
                   
               
               
                   
                 GAAGAACCAGCAATGGAAATGAAAAGAGGACCACTTTTCAGTCATCTG 
                   
               
               
                   
                 TCTTCTCAAAACATAGAAGAAAGTGCCTATTTTGATTCCACGTGGAAGG 
                   
               
               
                   
                 GTCTAACAGCTCTAGGAGGCCTGTATTTCATGTTTCTTGTTGAACATGTC 
                   
               
               
                   
                 CTCACATTGATCAAACAATTTAAAGATAAGAAGAAAAAGAATCAGAAG 
                   
               
               
                   
                 AAACCTGAAAATGATGATGATGTGGAGATTAAGAAGCAGTTGTCCAAG 
                   
               
               
                   
                 TATGAATCTCAACTTTCAACAAATGAGGAGAAAGTAGATACAGATGAT 
                   
               
               
                   
                 CGAACTGAAGGCTATTTACGAGCAGACTCACAAGAGCCCTCCCACTTTG 
                   
               
               
                   
                 ATTCTCAGCAGCCTGCAGTCTTGGAAGAAGAAGAGGTCATGATAGCTC 
                   
               
               
                   
                 ATGCTCATCCACAGGAAGTCTACAATGAATATGTACCCAGAGGGTGCA 
                   
               
               
                   
                 AGAATAAATGCCATTCACATTTCCACGATACACTCGGCCAGTCAGACGA 
                   
               
               
                   
                 TCTCATTCACCACCATCATGACTACCATCATATTCTCCATCATCACCACC 
                   
               
               
                   
                 ACCAAAACCACCATCCTCACAGTCACAGCCAGCGCTACTCTCGGGAGG 
                   
               
               
                   
                 AGCTGAAAGATGCCGGCGTCGCCACTCTGGCCTGGATGGTGATAATGG 
                   
               
               
                   
                 GTGATGGCCTGCACAATTTCAGCGATGGCCTAGCAATTGGTGCTGCTTT 
                   
               
               
                   
                 TACTGAAGGCTTATCAAGTGGTTTAAGTACTTCTGTTGCTGTGTTCTGTC 
                   
               
               
                   
                 ATGAGTTGCCTCATGAATTAGGTGACTTTGCTGTTCTACTAAAGGCTGG 
                   
               
               
                   
                 CATGACCGTTAAGCAGGCTGTCCTTTATAATGCATTGTCAGCCATGCTG 
                   
               
               
                   
                 GCGTATCTTGGAATGGCAACAGGAATTTTCATTGGTCATTATGCTGAAA 
                   
               
               
                   
                 ATGTTTCTATGTGGATATTTGCACTTACTGCTGGCTTATTCATGTATGTT 
                   
               
               
                   
                 GCTCTGGTTGATATGGTACCTGAAATGCTGCACAATGATGCTAGTGACC 
                   
               
               
                   
                 ATGGATGTAGCCGCTGGGGGTATTTCTTTTTACAGAATGCTGGGATGCT 
                   
               
               
                   
                 TTTGGGTTTTGGAATTATGTTACTTATTTCCATATTTGAACATAAAATCG 
                   
               
               
                   
                 TGTTTCGTATAAATTTCTAGTTAAGGTTTAAATGCTAGAGTAGCTTAAA 
                   
               
               
                   
                 AAGTTGTCATAGTTTCAGTAGGTCATAGGGAGATGAGTTTGTATGCTGT 
                   
               
               
                   
                 ACTATGCAGCGTTTAAAGTTAGTGGGTTTTGTGATTTTTGTATTGAATAT 
                   
               
               
                   
                 TGCTGTCTGTTACAAAGTCAGTTAAAGGTACGTTTTAATATTTAAGTTAT 
                   
               
               
                   
                 TCTATCTTGGAGATAAAATCTGTATGTGCAATTCACCGGTATTACCAGT 
                   
               
               
                   
                 TTATTATGTAAACAAGAGATTTGGCATGACATGTTCTGTATGTTTCAGG 
                   
               
               
                   
                 GAAAAATGTCTTTAATGCTTTTTCAAGAACTAACACAGTTATTCCTATA 
                   
               
               
                   
                 CTGGATTTTAGGTCTCTGAAGAACTGCTGGTGTTTAGGAATAAGAATGT 
                   
               
               
                   
                 GCATGAAGCCTAAAATACCAAGAAAGCTTATACTGAATTTAAGCAAAG 
                   
               
               
                   
                 AAATAAAGGAGAAAAGAGAAGAATCTGAGAATTGGGGAGGCATAGAT 
                   
               
               
                   
                 TCTTATAAAAATCACAAAATTTGTTGTAAATTAGAGGGGAGAAATTTAG 
                   
               
               
                   
                 AATTAAGTATAAAAAGGCAGAATTAGTATAGAGTACATTCATTAAACA 
                   
               
               
                   
                 TTTTTGTCAGGATTATTTCCCGTAAAAACGTAGTGAGCACTTTTCATATA 
                   
               
               
                   
                 CTAATTTAGTTGTACATTTAACTTTGTATAATACAGAAATCTAAATATAT 
                   
               
               
                   
                 TTAATGAATTCAAGCAATATATCACTTGACCAAGAAATTGGAATTTCAA 
                   
               
               
                   
                 AATGTTCGTGCGGGTATATACCAGATGAGTACAGTGAGTAGTTTTATGT 
                   
               
               
                   
                 ATCACCAGACTGGGTTATTGCCAAGTTATATATCACCAAAAGCTGTATG 
                   
               
               
                   
                 ACTGGATGTTCTGGTTACCTGGTTTACAAAATTATCAGAGTAGTAAAAC 
                   
               
               
                   
                 TTTGATATATATGAGGATATTAAAACTACACTAAGTATCATTTGATTCG 
                   
               
               
                   
                 ATTCAGAAAGTACTTTGATATCTCTCAGTGCTTCAGTGCTATCATTGTGA 
                   
               
               
                   
                 GCAATTGTCTTTTATATACGGTACTGTAGCCATACTAGGCCTGTCTGTGG 
                   
               
               
                   
                 CATTCTCTAGATGTTTCTTTTTTACACAATAAATTCCTTATATCAGCTTG 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 AK098106 
                 AACGCACTTGGCGCGCGGCGCGGGCTGCAGACGGCTGCGAGGCGCTGG 
                 195 
               
               
                   
                 GCACAGGTGTCCTGATGGCAAATTTCAAGGGCCACGCGCTTCCAGGGA 
                   
               
               
                   
                 GTTTCTTCCTGATCATTGGGCTGTGTTGGTCAGTGAAGTACCCGCTGAA 
                   
               
               
                   
                 GTACTTTAGCCACACGCGGAAGAACAGCCCACTACATTACTATCAGCGT 
                   
               
               
                   
                 CTCGAGATCGTCGAAGCCGCAATTAGGACTTTGTTTTCCGTCACTGGGA 
                   
               
               
                   
                 TCCTGGCAGAGCAGTTTGTTCCGGATGGGCCCCACCTGCACCTCTACCA 
                   
               
               
                   
                 TGAGAACCACTGGATAAAGTTAATGAATTGGCAGCACAGCACCATGTA 
                   
               
               
                   
                 CCTATTCTTTGCAGTCTCAGGAATTGTTGACATGCTCACCTATCTGGTCA 
                   
               
               
                   
                 GCCACGTTCCCTTGGGGGTGGACAGACTGGTTATGGCTGTGGCAGTATT 
                   
               
               
                   
                 CATGGAAGGTTTCCTCTTCTACTACCACGTCCACAACCGGCCTCCGCTG 
                   
               
               
                   
                 GACCAGCACATCCACTCACTCCTGCTGTATGCTCTGTTCGGAGGGTGTG 
                   
               
               
                   
                 TTAGTATCTCCCTAGAGGTGATCTTCCGGGACCACATTGTGCTGGAACT 
                   
               
               
                   
                 TTTCCGAACCAGTCTCATCATTCTTCAGGGAACCTGGTTCTGGCAGATT 
                   
               
               
                   
                 GGGTTTGTGCTGTTCCCACCTTTTGGAACACCCGAATGGGACCAGAAGG 
                   
               
               
                   
                 ATGATGCCAACCTCATGTTCATCACCATGTGCTTCTGCTGGCACTACCTG 
                   
               
               
                   
                 GCTGCCCTCAGCATTGTGGCCGTCAACTATTCTCTTGTTTACTGCCTTTT 
                   
               
               
                   
                 GACTCGGATGAAGAGACACGGAAGGGGAGAAATCATTGGAATTCAGAA 
                   
               
               
                   
                 GCTGAATTCAGATGACACTTACCAGACCGCCCTCTTGAGTGGCTCAGAT 
                   
               
               
                   
                 GAGGAATGAGCCGAGATGCGGAGGGCGCAGATGTCCCACTGCACAGCT 
                   
               
               
                   
                 GGAATGAATGGAGTTCATCCCCTCCACCTGAATGCCTGCTGTGGTCTGA 
                   
               
               
                   
                 TCTTAAGGGTCTATATATTTGCACCTCCTCATTCAACACAGGGCTGGAG 
                   
               
               
                   
                 GTTCTACAACAGGAAATCAGGCCTACAGCATCCTGTGTATCTTGCAGTT 
                   
               
               
                   
                 GGGATTTTTAAACATACTATAAAGTCTGTGTTGGTATAGTACCCTTCAT 
                   
               
               
                   
                 AAGGAAAAATGAAGTAATGCCTATAAGTAGCAGGCCTTTGTGCCTCAG 
                   
               
               
                   
                 TGTCAAGAGAAATCAAGAGATGCTAAAAGCTTTACAATGGAAGTGGCC 
                   
               
               
                   
                 TCATGGATGAATCCGGGGTATGAGCCCAGGAGAACGTGCTGCTTTTGGT 
                   
               
               
                   
                 AACTTATCCCTTTTTCTCTTAAGAAAGCAGGTACTTTCTTATTAGAAATA 
                   
               
               
                   
                 TGTTAGAATGTGTAAGCAAACGACAGTGCCTTTAGAATTACAATTCTAA 
                   
               
               
                   
                 CTTACATATTTTTTGAAAGTAAAATAATTCACAAGCTTTGGTATTTTAAA 
                   
               
               
                   
                 ATTATTGTTAAACATATCATAACTAATCATACCAGGGTACTGCAATACC 
                   
               
               
                   
                 ACTGTTTATAAGTGACAAAATTAGGCCAAAGGTGATTTTTTTTTAAATC 
                   
               
               
                   
                 AGGAAGCTGGTTACTGGCTCTACTGAGAGTTGGAGCCCTGATGTTCTGA 
                   
               
               
                   
                 TTCTTCAAAGTCACCCTAAAAGAAGATCTGACAGGAAAGCTGTATAATG 
                   
               
               
                   
                 AGATAGAAAAACGTCAGGTATGGAAGGCTTTCAGTTTTAATATGGCTGA 
                   
               
               
                   
                 AAGCAAAGGATAACGAATTCAGAATTAGTAATGTAAAATCTTGATACC 
                   
               
               
                   
                 CTAATCTTGCTTCTGGATCTGTTCTTTTTTTAAAAAAACTTCCTTCACCG 
                   
               
               
                   
                 CGCCTATAATCCTAGCACTTTGGGAGGCCGAGGCAGGCAGATCACGGG 
                   
               
               
                   
                 GTCAGGAGATCAAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTA 
                   
               
               
                   
                 CTGAAAATACAAAAAATTAGCCGGGTGTGGTGGCGGGCGCCTGTAGTT 
                   
               
               
                   
                 CCAGCTACTCGGGAGGCTGAGGCAAGAGAATGGCATGAACCCGGTAGG 
                   
               
               
                   
                 GGAGCTTGCAGTGAGCCCAGATCATGCCACTGTACTCCAGCCTAGGTGA 
                   
               
               
                   
                 CAGAGCAAGACTCTGTCTCAAAAACAAGCAAACAGACTTCCTTCAACA 
                   
               
               
                   
                 AATATTTATTAAATATCCACTTTGCAACAGCACTGAAATGGCTGTAAGG 
                   
               
               
                   
                 ACTCCTGAGATATGTGTCCAGCAAGGAGTTTACAGTCAAACAGGAGAG 
                   
               
               
                   
                 ACATGCCTGTAGTTACATCCAGTGTGATGGGTGCTGAGAGGCAAGTACA 
                   
               
               
                   
                 AACCACGATG 
                   
               
               
                   
               
               
                 BQ056428 
                 TCCCGCCGCGCCACTTCGCCTGCCTCCGTCCCCCGCCCGCCGCGCCATG 
                 196 
               
               
                   
                 CCTGTGGCCGGCTCGGAGCTGCCGCGCCGGCCCTTGCCCCCCGCCGCAC 
                   
               
               
                   
                 AGGAGCGGGACGCCGAGCCGCGTCCGCCGCACGGGGAGCTGCAGTACC 
                   
               
               
                   
                 TGGGGCAGATCCAACACATCCTCCGCTGCGGCGTCAGGAAGGACGCCC 
                   
               
               
                   
                 GCCCGGGCACCGGTACCCTGCCGGTATTCGGCATGCAGGCGCGCTACA 
                   
               
               
                   
                 GCCTGAGAGATGAATTCCCTCTGCTGACAACCAAACGTGTGTTCTGGAA 
                   
               
               
                   
                 CGGTGCTTCGGAGGAGCTGCTGTGGCTTATCAAGGGATCCACAAACGCT 
                   
               
               
                   
                 ATAGACCTGTCTTCCCCGGCAGCGAAAATCTCGGGATGCCACTGGATCC 
                   
               
               
                   
                 CGACACTCTCTGGACACCCTGGGATTCTCCACCAGAGAAGAACGCGACT 
                   
               
               
                   
                 TGGGCCCAGTTTGTGGCTCTCAGCGGAGGCCTCCTGTGGCAGAATACAT 
                   
               
               
                   
                 ACATTTCCAATCAGATCACTTCCCGGACACGGACCNTGACCAGCCTGCC 
                   
               
               
                   
                 AAAAAGTGGATTTCCCCCCACCCCAGAACCCANCCCCTGACGCACAGA 
                   
               
               
                   
                 AACCAACCCATTCGTTGTTGCCGCCTTGCGAACCCCAACCAGAATCTCT 
                   
               
               
                   
                 CCCCCCTGGCCGGCGCGCCTGCCGCTGCCAATGCCCCTATGGCGGCCTC 
                   
               
               
                   
                 TTGGCCCGCACCTTCCAATTGGTCGCCCTGCGCAACCAGCGAGAAAACA 
                   
               
               
                   
                 CTGGCCCGCCCGTCTCCCCCCCGCTCCGCCTACCCCACTTAATGCGCCTC 
                   
               
               
                   
                 CGTGGCATGACGCACGCGTTTGGTGTCCGCCGCCGTCTCATGTCCGCGC 
                   
               
               
                   
                 GGTGTGGACCCCCTTTTCTCTCGCGGCACATCCCCCCTATTCCCTTGCCC 
                   
               
               
                   
                 TTTGGGGGGCACCCCCTCTAGACCCGCGCTTCTCTTCTCGTCCGGTGGG 
                   
               
               
                   
                 GGACATTGGTTTGCCTGCCGCGGCGGGGGCGNTAAAAATAAAAACAGC 
                   
               
               
                   
                 CTGTTAGCCCGGCCCAGTACCCCCCCCCGGCCGGGGCCGCCTTNCGTTT 
                   
               
               
                   
                 GCATTTATACCCCAACCCATAAAGCCGCGCCCCTTTAGCNCCNTAACTT 
                   
               
               
                   
                 TTGTGGTGTGGCCTCCCCCCTTTTTCCCGGGGAGCAGCAACGGACATCT 
                   
               
               
                   
                 GTACACTAATGCTGGCCCCGACCTTTCCCAAAAACCCCCCGCCCGTGTC 
                   
               
               
                   
                 CCGTATAAATTTGGTGCCAANCCTGACGNGTTCTCCCCCGCCCTCGCCC 
                   
               
               
                   
                 CGTTGGCCGCCCGTTTAAAGCCCCCCCGGTGGTTGCGCCGCCCAACGAG 
                   
               
               
                   
                 TCCACCTATAGTTAANTCCACCAACACCCCCACCTTTTCCTCCCCGCCGC 
                   
               
               
                   
                 ATCTTCCCCACGTACCCCCTTTTGTCGCGAGATGGCCACTCCCCCCCCCC 
                   
               
               
                   
                 TGTTTGTTTAAAACAACGAGAATGGTGCTGCCAACGCTGGTCTTTTCCC 
                   
               
               
                   
                 CCCCCGGACCGCGACCGCCAGGGGGAATACGTACCATAAGCCCCCGCG 
                   
               
               
                   
                 CCCNCCTTTTTTCCCCCCTCCCCGCCAATCAAGATCCGCCGTCCATTAGA 
                   
               
               
                   
                 CGTATTATTTTTCCCGCGATACACGAAAAAACAGGGCCGCCCATTTATA 
                   
               
               
                   
                 ACTAAATTCCCGTCGCCGCCGCGCGGATATGTTTCCCAAAATACCACCC 
                   
               
               
                   
                 CCCCCCCCCCATTTTCTTTGCCCCCAACTCCTGCGCACCGGTGTTCACCA 
                   
               
               
                   
                 GCCTCGCGCCGC 
                   
               
               
                   
               
               
                 BC032677 
                 GGACGCGTGGGTCGACCCACGCGTCCGGACCCACGCGTCCGGTCGTGTT 
                 197 
               
               
                   
                 CTCCGAGTTCCTGTCTCTCTGCCAACGCCGCCCGGATGGCTTCCCAAAA 
                   
               
               
                   
                 CCGCGACCCAGCCGCCACTAGCGTCGCCGCCGCCCGTAAAGGAGCTGA 
                   
               
               
                   
                 GCCGAGCGGGGGCGCCGCCCGGGGTCCGGTGGGCAAAAGGCTACAGCA 
                   
               
               
                   
                 GGAGCTGATGACCCTCATGGTGAGTGATTAAGTGCCCAGAACCCCAGC 
                   
               
               
                   
                 CTTCCATCCAATTTTCAGTAGCCTCCTTTTTTCCGTCAGCTTTTTTGCTAG 
                   
               
               
                   
                 ACATAGGGGTAATGTAATTTGCTCCCTCCTGGGAAAGAAGTTCATACAC 
                   
               
               
                   
                 CCCACCTACACCATTTCTTCCAGCAGTCCCTCCTCCCAATTCCATCCCCC 
                   
               
               
                   
                 CACACGAAGTTATCTCGAACACTTCCCTGAAGTCATACAAGACCCTCCC 
                   
               
               
                   
                 TATCCAGTGTGTCCCTACTTCCTAGCCCCAACCAAGCTTTACCCACACCC 
                   
               
               
                   
                 AACTCCCCGCCCTTCTTGGTATTTCTAGCCTATGAATTTGGTTGCTTTAT 
                   
               
               
                   
                 TTTGGATCAGAGTGATGAGATTAAGGGGAGGCTGGGCGCGGTAGCTCA 
                   
               
               
                   
                 CACCTTATAATCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCC 
                   
               
               
                   
                 CGGCCAGCAACTAATATTCTAATTGAACTAAAGCACAGGATGCCAATTT 
                   
               
               
                   
                 ACAATCCTTAGACCAAAGAGTCACTGATGTCTCCACCAGATAAGAGGA 
                   
               
               
                   
                 AAGCATCAGGCTAGGCATAGTGGCTCACACCTGTAATCTCAGCACTTTG 
                   
               
               
                   
                 GGAGGCTGAGGCAGGCAGATCACATGAGCCCAGGAGTTTGAGACTGGC 
                   
               
               
                   
                 CTGGGCAACATGGTGAAACCCTGTCTCTAAAATAAAAACTAAACTAAA 
                   
               
               
                   
                 AAAACTTTTTAAAAAGGCAGTGGGGAGCATCAGAACCAGCTCAACAGT 
                   
               
               
                   
                 TTGTCTACTGTCCGGTCCCAGAGAAACTCAAGATTCTAGCAAGCCCCTT 
                   
               
               
                   
                 GTGTGGGGCTTGGGTTGGGACATGAGGCTGCTGCTGGAGCTTACTCTGC 
                   
               
               
                   
                 AACTGTTTCTCCAAATGCCAGGTATATGAAGACCTGAGGTATAAGCTCT 
                   
               
               
                   
                 CGCTAGAGTTCCCCAGTGGCTACCCTTACAATGCGCCCACAGTGAAGTT 
                   
               
               
                   
                 CCTCACGCCCTGCTATCACCCCAACGTGGACACCCAGGGTAACATATGC 
                   
               
               
                   
                 CTGGACATCCTGAAGGAAAAGTGGTCTGCCCTGTATGATGTCAGGACCA 
                   
               
               
                   
                 TTCTGCTCTCCATCCAGAGCCTTCTAGGAGAACCCAACATTGATAGTCC 
                   
               
               
                   
                 CTTGAACACACATGCTGCCGAGCTCTGGAAAAACCCCACAGCTTTTAAG 
                   
               
               
                   
                 AAGTACCTGCAAGAAACCTACTCAAAGCAGGTCACCAGCCAGGAGCCC 
                   
               
               
                   
                 TGACCCAGGCTGCCCAGCCTGTCCTTGTGTCGTCTTTTTAATTTTTCCTT 
                   
               
               
                   
                 AGATGGTCTGTCCTTTTTGTGATTTCTGTATAGGACTCTTTATCTTGAGC 
                   
               
               
                   
                 TGTGGTATTTTTGTTTTGTTTTTGTCTTTTAAATTAAGCCTCGGTTGAGCC 
                   
               
               
                   
                 CTTGTATATTAAATAAATGCATTTTTGTCCTTTTTTAAAAAAAAAATAAA 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 
               
               
                   
               
            
           
         
       
     
     The NANO46 gene expression assay, as described herein, is able to identify intrinsic subtype from standard formalin fixed paraffin embedded tumor tissue (also see, Parker et al.  J. Clin Oncol.,  27(8):1160-7 (2009) and U.S. Patent Application Publication No. 2013/0337444 The methods utilize a supervised algorithm to classify subject samples according to breast cancer intrinsic subtype. This algorithm, referred to herein as the “NANO46 classification model”, is based on the gene expression profile of a defined subset of intrinsic genes that has been identified herein as superior for classifying breast cancer intrinsic subtypes; see, U.S. Patent Application Publication No. 2013/0337444. In particular, expression of 46 of the genes listed in Table 1 is determined (which is by determining the expression of all 50 genes in Table 1 with the exception of determining the expression of MYBL2, BIRC5, GRB7 and CCNB1), i.e., the “NANO46” set of genes. The skilled artisan can utilize any primer and/or target sequence-specific probe for detecting any of (or each of) the genes in Table 1. 
     At least 10, at least 15, at least 20, at least 25, at least 40, at least 41, at least 42, at least 43, at least 44, at least 46, at least 47, at least 48, at least 49 or all 50 of the genes in Table 1 can be utilized in the methods and kits of the present invention. Preferably, the expression of each of the 50 genes is determined in a biological sample. More preferably, the expression of each of the genes in the NANO46 set of genes is determined in a biological sample. The prototypical gene expression profiles (i.e., centroid) of the four intrinsic subtypes were pre-defined from a training set of formalin fixed paraffin embedded tissues (FFPE) breast tumor samples using hierarchical clustering analysis of gene expression data. Table 4 shows the actual values of the prototypical gene expression profiles (i.e., centroids) of these four subtypes and for a normal sample. 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Table 4. Subtype Centroids for Comparison to a Sample 
               
               
                 Subtype Centroids for Comparison to a Sample 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Her2- 
                   
                   
                   
               
               
                 Target Gene 
                 Basal-like 
                 enriched 
                 Luminal A 
                 Luminal B 
                 Normal 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 ACTR3B 
                 −0.2052 
                 −0.7965 
                 −0.2790 
                 −0.4380 
                 0.6676 
               
               
                 ANLN 
                 1.0227 
                 0.5006 
                 −0.7289 
                 0.1149 
                 −1.7879 
               
               
                 BAG1 
                 −0.4676 
                 −0.3132 
                 0.4716 
                 0.5879 
                 −0.3280 
               
               
                 BCL2 
                 −0.7365 
                 −0.7237 
                 0.7234 
                 0.6363 
                 0.5144 
               
               
                 BIRC5 
                 0.9542 
                 0.4541 
                 −0.6921 
                 0.3421 
                 −1.6821 
               
               
                 BLVRA 
                 −0.8761 
                 0.2270 
                 0.1628 
                 0.7138 
                 −0.2665 
               
               
                 CCNB1 
                 0.7337 
                 0.3114 
                 −0.8626 
                 0.2165 
                 −1.5967 
               
               
                 CCNE1 
                 1.3100 
                 0.2201 
                 −0.6231 
                 −0.2729 
                 −1.0925 
               
               
                 CDC20 
                 1.0995 
                 0.1445 
                 −1.0518 
                 −0.1173 
                 −1.2069 
               
               
                 CDC6 
                 0.5817 
                 0.6601 
                 −0.7032 
                 0.3134 
                 −1.2255 
               
               
                 CDCA1 
                 0.9367 
                 0.1623 
                 −0.4509 
                 0.2692 
                 −1.9055 
               
               
                 CDH3 
                 0.7639 
                 0.0144 
                 −0.0502 
                 −1.0229 
                 0.5007 
               
               
                 CENPF 
                 1.0222 
                 0.2944 
                 −0.5657 
                 0.2437 
                 −1.8612 
               
               
                 CEP55 
                 1.0442 
                 0.4881 
                 −0.6365 
                 0.2921 
                 −1.9241 
               
               
                 CXXC5 
                 −0.9732 
                 0.1866 
                 0.5687 
                 0.9463 
                 −0.3030 
               
               
                 EGFR 
                 0.3352 
                 −0.1326 
                 −0.0011 
                 −0.9755 
                 1.4238 
               
               
                 ERBB2 
                 −0.7045 
                 1.4182 
                 0.2420 
                 0.1978 
                 −0.5530 
               
               
                 ESR1 
                 −1.1847 
                 −0.4926 
                 0.7177 
                 1.0101 
                 0.0087 
               
               
                 EXO1 
                 1.0546 
                 0.4317 
                 −0.7259 
                 0.2559 
                 −1.6488 
               
               
                 FGFR4 
                 −0.2073 
                 1.4562 
                 0.1707 
                 −0.2223 
                 −0.5802 
               
               
                 FOXA1 
                 −1.3590 
                 0.5726 
                 0.7131 
                 0.7963 
                 −0.2353 
               
               
                 FOXC1 
                 1.0666 
                 −0.7362 
                 −0.4078 
                 −0.9877 
                 0.6650 
               
               
                 GPR160 
                 −1.0540 
                 0.5524 
                 0.6032 
                 0.7305 
                 −0.3224 
               
               
                 GRB7 
                 −0.4848 
                 1.3418 
                 0.0124 
                 0.0690 
                 −0.2520 
               
               
                 KIF2C 
                 0.9242 
                 0.1104 
                 −1.1001 
                 −0.2771 
                 −1.3455 
               
               
                 KNTC2 
                 1.1373 
                 0.2266 
                 −0.7593 
                 0.1656 
                 −1.1881 
               
               
                 KRT14 
                 0.4759 
                 −0.5269 
                 0.8187 
                 −0.8879 
                 1.1352 
               
               
                 KRT17 
                 0.6863 
                 −0.3777 
                 0.6149 
                 −1.1415 
                 0.9238 
               
               
                 KRT5 
                 0.7136 
                 −0.4146 
                 0.5832 
                 −0.9462 
                 1.0985 
               
               
                 MAPT 
                 −1.1343 
                 −0.2711 
                 1.0957 
                 0.8372 
                 0.4007 
               
               
                 MDM2 
                 −0.7498 
                 −0.4855 
                 −0.1788 
                 0.2397 
                 0.1097 
               
               
                 MELK 
                 1.0209 
                 0.2678 
                 −0.8016 
                 0.1012 
                 −1.6272 
               
               
                 MIA 
                 1.2408 
                 −0.5475 
                 0.3289 
                 −0.6320 
                 0.6975 
               
               
                 MKI67 
                 1.0446 
                 0.4630 
                 −0.6717 
                 0.3161 
                 −1.7680 
               
               
                 MLPH 
                 −1.4150 
                 0.4842 
                 0.8829 
                 0.8194 
                 −0.2419 
               
               
                 MMP11 
                 −0.1295 
                 0.5220 
                 0.3402 
                 0.5653 
                 −1.7370 
               
               
                 MYBL2 
                 0.9571 
                 0.5492 
                 −0.7814 
                 0.1548 
                 −1.4404 
               
               
                 MYC 
                 0.5639 
                 −0.9904 
                 −0.3015 
                 −0.2791 
                 0.9833 
               
               
                 NAT1 
                 −0.9711 
                 −0.2708 
                 1.2256 
                 0.9576 
                 −0.5287 
               
               
                 ORC6L 
                 1.0086 
                 0.5152 
                 −1.0385 
                 −0.0336 
                 −1.4084 
               
               
                 PGR 
                 −0.9216 
                 −0.5755 
                 1.2061 
                 0.9278 
                 0.6220 
               
               
                 PHGDH 
                 0.9192 
                 0.0322 
                 −0.5194 
                 −0.5371 
                 0.5184 
               
               
                 PTTG1 
                 0.9541 
                 0.2079 
                 −1.1207 
                 0.1052 
                 −1.4067 
               
               
                 RRM2 
                 0.7895 
                 0.6336 
                 −0.8099 
                 0.3228 
                 −1.7630 
               
               
                 SFRP1 
                 0.7694 
                 −0.8271 
                 0.2617 
                 −1.0846 
                 1.3790 
               
               
                 SLC39A6 
                 −0.9992 
                 −0.4573 
                 0.6607 
                 0.9222 
                 −0.2463 
               
               
                 TMEM45B 
                 −1.0721 
                 0.7926 
                 0.3190 
                 0.2016 
                 −0.2250 
               
               
                 TYMS 
                 0.9823 
                 −0.0960 
                 −0.8593 
                 0.1827 
                 −1.3192 
               
               
                 UBE2C 
                 0.8294 
                 0.3358 
                 −1.0141 
                 0.0608 
                 −1.7637 
               
               
                 UBE2T 
                 0.6258 
                 0.0617 
                 −0.8652 
                 −0.0487 
                 −1.8602 
               
               
                   
               
            
           
         
       
     
       FIG. 9  outlines the assay processes associated with the Breast Cancer Intrinsic Subtyping test. Following RNA isolation, the test will simultaneously measure the expression levels of at least 40 target genes (e.g., 46 or 50) plus eight housekeeping genes. For example, the housekeeping genes described in U.S. Patent Publication 2008/0032293 can be used for normalization. Exemplary housekeeping genes include MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLP0, and TFRC. The housekeeping genes are used to normalize the expression of the tumor sample. Each assay run may also include a reference sample consisting of in vitro transcribed RNA&#39;s of the target genes and the housekeeping genes for normalization purposes. 
     After performing the Breast Cancer Intrinsic Subtyping test with a test breast cancer tumor sample and the reference sample provided as part of a test kit or as used in a method, a computational algorithm based on a Pearson&#39;s correlation compares the normalized and scaled gene expression profile of the at least 40 genes or the PAM50 or NANO46 intrinsic gene sets of the test sample to the prototypical expression signatures of the four breast cancer intrinsic subtypes. See, U.S. Patent Application Publication Nos. 2011/0145176 and 2013/0337444. In embodiments, the intrinsic subtype analysis is determined by determining the expression of a PAM50 or NANO46 sets of genes and the risk of recurrence (“ROR”) is determined using the NANO46 set of genes (which is determining the expression of all 50 genes in Table 1 with the exception of determining the expression of MYBL2, BIRC5, GRB7 and CCNB1). Specifically, the intrinsic subtype is identified by comparing the expression of the at least 40 genes or the PAM50 or NANO46 set of genes in the biological sample with the expected expression profiles for the four intrinsic subtypes. The subtype with the most similar expression profile is assigned to the biological sample. The ROR score is an integer value on a 0-100 scale that is related to an individual patient&#39;s probability of distant recurrence within 10 years for the defined intended use population. The ROR score is calculated by comparing the expression profiles of the at least 40 genes, e.g., the NANO46 genes, in the biological sample with the expected profiles for the four intrinsic subtypes, as described above, to calculate four different correlation values. These correlation values may then be combined with a proliferation score (and optionally one or more clinicopathological variables, such as tumor size) to calculate the ROR score. Preferably, the ROR score is calculated by comparing only the expression profiles of the NANO46 genes. 
     A ROR score can be calculated using any method or formula known in the art. Exemplary formulae include Equations 1 to 6, as described herein. 
       FIG. 10  provides a schematic of specific algorithm transformations. The tumor sample is assigned the subtype with the largest positive correlation to the sample. Kaplan Meier survival curves are generated from a training set of untreated breast cancer patients demonstrate that the intrinsic subtypes are a prognostic indicator of recurrence free survival (RFS). 
     The training set of formalin fixed paraffin embedded tissues (FFPE) breast tumor samples, which had well defined clinical characteristics and clinical outcome data, were used to establish a continuous Risk of Recurrence (ROR) score. The score is calculated using coefficients from a Cox model that includes correlation to each intrinsic subtype, a proliferation score (mean gene expression of a subset of 18 of the 46 genes), and tumor size. See, Table 5. 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Coefficients to calculate ROR-PT (Equation 1) 
               
            
           
           
               
               
               
            
               
                   
                 Test Variables 
                 Coefficient 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Basal-like Pearson&#39;s correlation (A) 
                 −0.0067 
               
               
                   
                 HER2-enriched Pearson&#39;s correlation (B) 
                 0.4317 
               
               
                   
                 Luminal A Pearson&#39;s correlation (C) 
                 −0.3172 
               
               
                   
                 Luminal B Pearson&#39;s correlation (D) 
                 0.4894 
               
               
                   
                 Proliferation Score (E) 
                 0.1981 
               
               
                   
                 Tumor Size (F) 
                 0.1133 
               
               
                   
                   
               
            
           
         
       
     
     The test variables in Table 5 are multiplied by the corresponding coefficients and summed to produce a risk score (“ROR-PT”) as shown in the following equation (Equation 1): 
       ROR-PT equation=−0.0067 *A+ 0.4317 *B+− 0.3172 *C+ 0.4894 *D+ 0.1981 *E+ 0.1133 *F.  
 
     In previous studies, the ROR score provided a continuous estimate of the risk of recurrence for ER-positive, node-negative patients who were treated with tamoxifen for 5 years (Nielsen et al.  Clin. Cancer Res.,  16(21):5222-5232 (2009)). The ROR score also exhibited a statistically significant improvement over a clinical model based in determining relapse-free survival (RFS) within this test population providing further evidence of the improved accuracy of this decision making tool when compared to traditional clinicopathological measures (Nielsen et al.  Clin. Cancer Res.,  16(21):5222-5232 (2009)). 
     The ROR score is an integer value on a 0-100 scale that is related to an individual patient&#39;s probability of distant recurrence within 10 years for the defined intended use population. The ROR score is calculated by comparing the expression profiles of 46 genes in an unknown sample with the expected profiles for the four intrinsic subtypes, as described above, to calculate four different correlation values. These correlation values are then combined with a proliferation score and the tumor size to calculate the ROR score. Risk classification is also provided to allow interpretation of the ROR score by using cutoffs related to clinical outcome in tested patient populations. See, Table 6. 
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Risk classification by ROR range and nodal status 
               
            
           
           
               
               
               
               
            
               
                   
                 Nodal Status 
                 ROR Range 
                 Risk Classification 
               
               
                   
                   
               
               
                   
                 Node-Negative 
                 0-40 
                 Low 
               
               
                   
                   
                 41-60  
                 Intermediate 
               
               
                   
                   
                 61-100 
                 High 
               
               
                   
                 Node-Positive 
                 0-15 
                 Low 
               
               
                   
                 (1-3 nodes) 
                 16-40  
                 Intermediate 
               
               
                   
                   
                 41-100 
                 High 
               
               
                   
                   
               
            
           
         
       
     
     The methods and kits of the present invention can further include steps and/or reagents for providing a VEGF-signature score. The VEGF-signature score can be determined from the expression of at least one of, a combination of, or each of, a 13-gene set of genes associated with VEGF signaling or regulation. The 13-gene set includes RRAGD, FABP5, UCHL1, GAL, PLOD, DDIT4, VEGF, ADM, ANGPTL4, NDRG1, NP, SLC16A3, and C14ORF 58. Table 7 provides the Genbank Accession Numbers and select nucleic acid sequences of the 13-gene set for determining the VEGF-signature score. 
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 VEGF Signature Score Gene Set 
               
            
           
           
               
               
               
            
               
                 GENE NAME 
                   
                   
               
               
                 GENBANK 
                   
                 SEQ 
               
               
                 ACCESSION 
                   
                 ID 
               
               
                 NUMBER 
                 SEQUENCE 
                 NO: 
               
               
                   
               
               
                 RRAGD 
                 CGCAGTCTCTCTCTCTCTCCCTCCTCCGGGAGGAACTGCCGCGCTCCGGCT 
                 198 
               
               
                 NM_021244.4 
                 GACTCCTCCGCCGGCGGGCGGGGCGGGGGAGGGGGCTTCGGGCGCGCTG 
                   
               
               
                   
                 GGAACCGCGGGACCCGGACCTGGGCGCCGCCCGCCGGGGGACGCGCGGC 
                   
               
               
                   
                 CCCCGCTTCCGCCGGGCCCCGCTGAGCTCTAGACAAACCTCCGCTTCAGA 
                   
               
               
                   
                 AATAGGCTGCGGGCGGCCGGCTAGGAGGCTTGGCCCCCACCCCGGGACC 
                   
               
               
                   
                 CCCGCCGTCCCCGGGCCGGCCGGCCGGTGGGCACGATGAGCCAGGTGCTG 
                   
               
               
                   
                 GGGAAGCCGCAGCCGCAGGACGAGGACGACGCGGAGGAGGAGGAGGAG 
                   
               
               
                   
                 GAGGATGAGCTGGTGGGGCTAGCGGACTACGGAGACGGGCCCGACTCCT 
                   
               
               
                   
                 CCGACGCCGATCCGGACAGCGGCACAGAGGAGGGAGTTCTGGACTTCAG 
                   
               
               
                   
                 TGACCCCTTCAGCACTGAAGTGAAGCCGAGAATCCTGCTCATGGGCCTGA 
                   
               
               
                   
                 GGAGAAGCGGCAAGTCGTCTATTCAGAAAGTTGTCTTTCACAAAATGTCT 
                   
               
               
                   
                 CCCAACGAAACTCTGTTCTTGGAGAGCACTAATAAGATATGCCGGGAAGA 
                   
               
               
                   
                 TGTTTCCAACAGCTCCTTTGTCAATTTTCAGATTTGGGACTTCCCAGGACA 
                   
               
               
                   
                 GATTGACTTTTTTGACCCTACATTTGACTATGAGATGATCTTCCGGGGAAC 
                   
               
               
                   
                 AGGAGCACTGATATTTGTCATTGACTCACAGGATGATTACATGGAAGCCC 
                   
               
               
                   
                 TGGCCAGGCTCCACCTCACGGTGACCAGGGCCTACAAAGTGAATACTGAC 
                   
               
               
                   
                 ATCAACTTCGAGGTGTTTATTCATAAAGTGGATGGTCTGTCAGATGACCA 
                   
               
               
                   
                 CAAAATTGAAACCCAAAGAGATATTCACCAGAGGGCAAACGATGACCTT 
                   
               
               
                   
                 GCAGATGCTGGATTAGAAAAAATTCACCTCAGCTTTTATCTGACAAGCAT 
                   
               
               
                   
                 ATATGATCATTCAATATTTGAAGCTTTTAGCAAAGTTGTTCAGAAACTGAT 
                   
               
               
                   
                 TCCACAACTCCCAACTCTGGAGAATTTGCTGAACATCTTTATCTCAAATTC 
                   
               
               
                   
                 TGGAATTGAAAAGGCATTTCTATTTGATGTGGTCAGTAAAATTTATATTGC 
                   
               
               
                   
                 AACTGATAGTACTCCGGTGGATATGCAAACCTATGAGCTCTGCTGTGATA 
                   
               
               
                   
                 TGATAGATGTGGTTATTGACATCTCTTGTATTTATGGTCTCAAAGAAGATG 
                   
               
               
                   
                 GAGCAGGAACCCCCTATGACAAGGAATCCACAGCCATCATAAAGCTTAAT 
                   
               
               
                   
                 AATACAACCGTGCTTTATTTAAAAGAGGTGACAAAGTTCCTGGCTCTCGT 
                   
               
               
                   
                 TTGCTTTGTCAGAGAGGAAAGCTTTGAAAGAAAAGGGCTAATTGACTATA 
                   
               
               
                   
                 ATTTTCATTGCTTCCGGAAGGCCATTCATGAAGTTTTTGAGGTGAGAATGA 
                   
               
               
                   
                 AAGTAGTAAAATCTCGAAAGGTTCAGAATCGGCTGCAGAAGAAAAAGAG 
                   
               
               
                   
                 AGCCACCCCTAATGGGACCCCTAGAGTGCTGCTGTAGGTGAGGTTTCAGG 
                   
               
               
                   
                 AATGTCTTTTGAAATCAGACCTTATCCATGAGGCTGCTGCGCCATGTTGCA 
                   
               
               
                   
                 CTAAAGGAAGAGGAAGAAGGAGATTGGGACACATACCATTGATTTGTTG 
                   
               
               
                   
                 TTAAAAAAAAAAAATTCCTGCAACCCTCTTGATCTTCTCTTTTATAAATAA 
                   
               
               
                   
                 AGTAAGCACTTTGAAGCAAAAACTTGTATATTAACAGTGAATGTGAAATCC 
                   
               
               
                   
                 ATTGTCATTTCATTACACAAATGTAAACTTTTATGGTCTGTAGTCAAAAAA 
                   
               
               
                   
                 ATCCCGTGTGAGAACTGCCAGGAATTGTACATATTTTGCACTTTTTCATGT 
                   
               
               
                   
                 TTCTCATTGAACTGAACTTTGATAAAACGACTTTTCTAAGCTTTTTTTCTGT 
                   
               
               
                   
                 ACTTGGTGTCAAGGACATGCATACTGTAGTCCATATCTATATGGCAATCA 
                   
               
               
                   
                 GAAATTAATCAAAAAGTGATGCATTGGTAATGACTTTTTGTAAATTTGGA 
                   
               
               
                   
                 AATCTTTGCTACCAATTGTTGAGAAAAATCATTTTTCAGTGGAGCTGGAA 
                   
               
               
                   
                 CAGATTGGAGCTACAAGCTCCAGGAGCAATAAGAACTGTCCCCTATTTAT 
                   
               
               
                   
                 AATGGGTGTAAACAGTTTTGTAGAATAATGCTAGCACCAGACTTACCTAA 
                   
               
               
                   
                 AAATTTCTATAGCAGTGGCTGTGCTTCCCTGCTCAACGGTTTTTATGAAGC 
                   
               
               
                   
                 TGTTTACCTCAACACACATCTCTATAATCACTTTATACAGAGAGGTTATTT 
                   
               
               
                   
                 CTTTTTGTTGCATTAGTATTCTTTTGAAACTTTGGGACCAGATTTCCAAAA 
                   
               
               
                   
                 TGGTGCCGAACACTGGAGAGAAGTAAGAATGTCACTGAATTGTAGGGTTT 
                   
               
               
                   
                 CTGGAGGCTTTTCTGTACCTACCACCCAGGGCTAAAGTAACATCAGAGGC 
                   
               
               
                   
                 CTAAAGTTGTTCCAAAAGTATGTGATTGGCAACTGCAGACTAAAAAACAT 
                   
               
               
                   
                 AGATACAATTCTGGACTTTTGGCCCTGTGCGATGGTCTGGTGTGCTGCATT 
                   
               
               
                   
                 TAAAATGCTTATTCAGGACCAGTTCTTTATTGCTCCATGACCATAGTGAAT 
                   
               
               
                   
                 AGAACAAATCGCAGAACCCCACCATGGAGCTCAATCCTGTTAGTCACTTT 
                   
               
               
                   
                 TGTCACCTCCACATCTCCTTCTCACTGGTGATAACATGCCTCATGTACTCC 
                   
               
               
                   
                 ACTTGTTCCCACCTTATGATTAAGCCAAGCTCAGCCTGCCACCAGCATGCT 
                   
               
               
                   
                 CTGCAAGGCTGAAGAGTCATCCTGAAGACCCCTAAAGGTCAGTGGGAAA 
                   
               
               
                   
                 AGGATGGCTGGAGAGACATTACAATTAGCTGTGTAATTGTTTCTGTGAAA 
                   
               
               
                   
                 TTATTTCACTTATGTTTACTTTAGACTAACAGGAAATTAAGAGTCCTAAAT 
                   
               
               
                   
                 CTACCCCTATGCCAAATCATTCCAAGTAGATAATTTTACGTGCATCTCAAG 
                   
               
               
                   
                 GGTTAGCACCCTAAGGCATGCTTGTGGGGCATTAGAAAATGAGATTTTTT 
                   
               
               
                   
                 TTTTTTTAAAGCAGAGCCTCCTAAGAACATCAAAGTTGGTCCTAGCAAAA 
                   
               
               
                   
                 TATATAAAGTCCCTAAAGCAACTTATACTTGAAACTTTTTTTTTTTTTTTTT 
                   
               
               
                   
                 TTAGAGGGGGGCCTCATTCTGTTGCTTGTGCTGGAATACATTGGTACAATC 
                   
               
               
                   
                 ATAGCTCACTGTTACCTCTTGGGCTCAAGGGATCCTTCCACCTCAGCCTCC 
                   
               
               
                   
                 CTAGTAGCTAGAACTACAGGTGTGCACAACCACGCCCGGCTAATTCTTAAZ 
                   
               
               
                   
                 ATTTTGTTTTTGTAGAGACAGGATCTCACTGTGTTGCCCAAGATGGTCTCA 
                   
               
               
                   
                 AACTCCTGGCCCCAAGCAATCCTCCTGCCTTGGCCTCCTCAAATGCTGAG 
                   
               
               
                   
                 ATTACAGGCCTGAGCTACTGTGCCCAGCCTAAACTTTCCCACTTCTCTCTG 
                   
               
               
                   
                 TGGCTTCTTTCCAACCTCTCTCCTTCCTCTCCCCAAGTCCTGTTTCTTTGAA 
                   
               
               
                   
                 GCTGGTAACTGAATTTAAGATGATATCTGGTTGGTGTTTAAGGTTTGAGCC 
                   
               
               
                   
                 TCCCAAGGTTCTGTGCATTTTGAAAGGAGATTTCTAAAAATAATTAAGGT 
                   
               
               
                   
                 GCCCTAACTCCTTTCCTCATGATTCCTACTCCGAAACCTGGATGGTTAGGA 
                   
               
               
                   
                 GCCCAGGGCTCCCTGATTTCCAGAGCTATATCCTGTTGGACCTTTGCCAAC 
                   
               
               
                   
                 AGACCTGACACTTAGGGGTTATTGTTATAAATCTAATTCTCTAATATTTTT 
                   
               
               
                   
                 TACATGTTGTTTCACTTTGAATAAGCAAATGAAGAATCAGTTTTCTAATAT 
                   
               
               
                   
                 GACTTTATCCTCAAGCTAGAGACACTAGCCTATTTGGTAAATCACACATT 
                   
               
               
                   
                 ACTTAGGTATATTTATTACTATAACCAGGTTGGAGCTTCCATGTTTAAGCT 
                   
               
               
                   
                 GGGTATATGATGGGTTTTTGTTAAAATGTGCCTTAAAAAGCCTATTACTTC 
                   
               
               
                   
                 AAGAGCAAATGATTCTTTGGGGGAAAGGCAAAAATAATTCTATGACATA 
                   
               
               
                   
                 GGGCCCAAGTTCATGGTAGTAAGTGTACTCTTTGATTAATCACACGCTAA 
                   
               
               
                   
                 TATAGATTACTGCCTCTAACTTTGTAAGTGTGGCAATGACTTCTTAATTAA 
                   
               
               
                   
                 AGAAAGATGCAGGAGTTATGTCTAAGCGTTCAGTTTTTCAAATCTGTGTT 
                   
               
               
                   
                 ATTGGAAATGTCTTCAAGTCATTTTGCATTGTATTTTTGATATGAGAGGCA 
                   
               
               
                   
                 GCTTATTGCGATGTGTATGGCCATGTTTCATTCTCAAATTTAATTCTATAA 
                   
               
               
                   
                 ATACAAATCCTAAATACATGGCTACAGCAACTGCACTGGAACATTTTTGC 
                   
               
               
                   
                 TTGGTTTTAGGGATTGAGAACTTGCCTTGCAGGTTTCCTTCCTCAAAAGGA 
                   
               
               
                   
                 GCAGGGCAGTCCTTTCCCTGTTGAGTCAATTAGAATTTTTACATAGAGGTG 
                   
               
               
                   
                 AGACTGTGAATTATTTTGGTTATTTTCAGTGATGTAGATTAGTGTGAATGA 
                   
               
               
                   
                 CCAGGGTGGAATGTTTTTGAAGGAATATAAAGCAAAAACTGGTTGACATT 
                   
               
               
                   
                 CACAAACTGTTCTTTTGTGAACATATTTTGGACCCTTAAATATGACTAAAA 
                   
               
               
                   
                 TCACAGCAATATTGTTACATACGGGTTATATGCCAACTCTGTTTGAAATAT 
                   
               
               
                   
                 ACTCTGGAAAAACAGCTGAATTGTCTTGGTTATTAAAGTATGGTATGTATT 
                   
               
               
                   
                 CAACTTGTACAGACTGGATGTAATTTGTAATCAGGTATAGTCCATGTTTTA 
                   
               
               
                   
                 CTTTAAGCAGTACATCACTTAATAACCATTGTTAAGCCATTGCTTTCAAGA 
                   
               
               
                   
                 ATGTTAACTGCCAATTTAAAAGCATGTGTCCTAGGTTCATGCTTTGGTAAA 
                   
               
               
                   
                 GCTCTCATTTCAAGTGTATTCATAGCTAAGCTTTCTGGGAGCAGAATTGTC 
                   
               
               
                   
                 TCTTTGGTGAAAAGGAAGTACAGCCTTTCCTGTTTCTGAGGTTGCTTACCA 
                   
               
               
                   
                 TACATGTATGTCACTGTTTCATTGGCCCTGTTACATCCATTTGGTAAAATT 
                   
               
               
                   
                 TATTTGTCCTGATTAACCAGCTCTCATTTTATGGAAATGATGATAAATCTC 
                   
               
               
                   
                 ACTACTTAAATTTAATTTATGCTTTTATTTTTAA 
                   
               
               
                   
               
               
                 FABP5 
                 CGCCGCCCAGCGCGGGCCGCCGTTATAAAGCAGCCGCCGGCGCCGGGTG 
                 199 
               
               
                 NM_001444.2 
                 CCTCACAGCACGCTGCCACGCCGACGCAGACCCCTCTCTGCACGCCAGCC 
                   
               
               
                   
                 CGCCCGCACCCACCATGGCCACAGTTCAGCAGCTGGAAGGAAGATGGCG 
                   
               
               
                   
                 CCTGGTGGACAGCAAAGGCTTTGATGAATACATGAAGGAGCTAGGAGTG 
                   
               
               
                   
                 GGAATAGCTTTGCGAAAAATGGGCGCAATGGCCAAGCCAGATTGTATCAT 
                   
               
               
                   
                 CACTTGTGATGGTAAAAACCTCACCATAAAAACTGAGAGCACTTTGAAAA 
                   
               
               
                   
                 CAACACAGTTTTCTTGTACCCTGGGAGAGAAGTTTGAAGAAACCACAGCT 
                   
               
               
                   
                 GATGGCAGAAAAACTCAGACTGTCTGCAACTTTACAGATGGTGCATTGGT 
                   
               
               
                   
                 TCAGCATCAGGAGTGGGATGGGAAGGAAAGCACAATAACAAGAAAATTG 
                   
               
               
                   
                 AAAGATGGGAAATTAGTGGTGGAGTGTGTCATGAACAATGTCACCTGTAC 
                   
               
               
                   
                 TCGGATCTATGAAAAAGTAGAATAAAAATTCCATCATCACTTTGGACAGG 
                   
               
               
                   
                 AGTTAATTAAGAGAATGACCAAGCTCAGTTCAATGAGCAAATCTCCATAC 
                   
               
               
                   
                 TGTTTCTTTCTTTTTTTTTTCATTACTGTGTTCAATTATCTTTATCATAAACA 
                   
               
               
                   
                 TTTTACATGCAGCTATTTCAAAGTGTGTTGGATTAATTAGGATCATCCCTT 
                   
               
               
                   
                 TGGTTAATAAATAAATGTGTTTGTGCTAATAAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
                 AA 
                   
               
               
                   
               
               
                 UCHL1 
                 AGTGCGTCTGGCCGGCGCTTTATAGCTGCAGCCTGGGCGGCTCCGCTAGC 
                 200 
               
               
                 NM_004181.4 
                 TGTTTTTCGTCTTCCCTAGGCTATTTCTGCCGGGCGCTCCGCGAAGATGCA 
                   
               
               
                   
                 GCTCAAGCCGATGGAGATCAACCCCGAGATGCTGAACAAAGTGCTGTCCC 
                   
               
               
                   
                 GGCTGGGGGTCGCCGGCCAGTGGCGCTTCGTGGACGTGCTGGGGCTGGAA 
                   
               
               
                   
                 GAGGAGTCTCTGGGCTCGGTGCCAGCGCCTGCCTGCGCGCTGCTGCTGCT 
                   
               
               
                   
                 GTTTCCCCTCACGGCCCAGCATGAGAACTTCAGGAAAAAGCAGATTGAAG 
                   
               
               
                   
                 AGCTGAAGGGACAAGAAGTTAGTCCTAAAGTGTACTTCATGAAGCAGAC 
                   
               
               
                   
                 CATTGGGAATTCCTGTGGCACAATCGGACTTATTCACGCAGTGGCCAATA 
                   
               
               
                   
                 ATCAAGACAAACTGGGATTTGAGGATGGATCAGTTCTGAAACAGTTTCTT 
                   
               
               
                   
                 TCTGAAACAGAGAAAATGTCCCCTGAAGACAGAGCAAAATGCTTTGAAA 
                   
               
               
                   
                 AGAATGAGGCCATACAGGCAGCCCATGATGCCGTGGCACAGGAAGGCCA 
                   
               
               
                   
                 ATGTCGGGTAGATGACAAGGTGAATTTCCATTTTATTCTGTTTAACAACGT 
                   
               
               
                   
                 GGATGGCCACCTCTATGAACTTGATGGACGAATGCCTTTTCCGGTGAACC 
                   
               
               
                   
                 ATGGCGCCAGTTCAGAGGACACCCTGCTGAAGGACGCTGCCAAGGTCTGC 
                   
               
               
                   
                 AGAGAATTCACCGAGCGTGAGCAAGGAGAAGTCCGCTTCTCTGCCGTGGC 
                   
               
               
                   
                 TCTCTGCAAGGCAGCCTAATGCTCTGTGGGAGGGACTTTGCTGATTTCCCC 
                   
               
               
                   
                 TCTTCCCTTCAACATGAAAATATATACCCCCCCATGCAGTCTAAAATGCTT 
                   
               
               
                   
                 CAGTACTTGTGAAACACAGCTGTTCTTCTGTTCTGCAGACACGCCTTCCCC 
                   
               
               
                   
                 TCAGCCACACCCAGGCACTTAAGCACAAGCAGAGTGCACAGCTGTCCACT 
                   
               
               
                   
                 GGGCCATTGTGGTGTGAGCTTCAGATGGTGAAGCATTCTCCCCAGTGTAT 
                   
               
               
                   
                 GTCTTGTATCCGATATCTAACGCTTTAAATGGCTACTTTGGTTTCTGTCTGT 
                   
               
               
                   
                 AAGTTAAGACCTTGGATGTGGTTTAATTGTTTGTCCTCAAAAGGAATAAA 
                   
               
               
                   
                 ACTTTTCTGCTGATAAGATAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 GAL 
                 ATATAGCAGCGGCGGCGGTGGCGGCGGCCACACCGGGCGGCGGACACGT 
                 201 
               
               
                 NM_015973.3 
                 GGAGGGACCCGGCCCGCGCCTTCTGCCCCTGCTGCCGGCCGCGCCATGCG 
                   
               
               
                   
                 GTGAGCGCCCCAGGCCGCCAGAGCCCACCCGACCCGGCCCGACGCCCGG 
                   
               
               
                   
                 ACCTGCCGCCCAGACCCGCCACCGCACCCGGACCCCGACGCTCCGAACCC 
                   
               
               
                   
                 GGGCGCAGCCGCAGCTCAAGATGGCCCGAGGCAGCGCCCTCCTGCTCGCC 
                   
               
               
                   
                 TCCCTCCTCCTCGCCGCGGCCCTTTCTGCCTCTGCGGGGCTCTGGTCGCCG 
                   
               
               
                   
                 GCCAAGGAAAAACGAGGCTGGACCCTGAACAGCGCGGGCTACCTGCTGG 
                   
               
               
                   
                 GCCCACATGCCGTTGGCAACCACAGGTCATTCAGCGACAAGAATGGCCTC 
                   
               
               
                   
                 ACCAGCAAGCGGGAGCTGCGGCCCGAAGATGACATGAAACCAGGAAGCT 
                   
               
               
                   
                 TTGACAGGTCCATACCTGAAAACAATATCATGCGCACAATCATTGAGTTT 
                   
               
               
                   
                 CTGTCTTTCTTGCATCTCAAAGAGGCCGGTGCCCTCGACCGCCTCCTGGAT 
                   
               
               
                   
                 CTCCCCGCCGCAGCCTCCTCAGAAGACATCGAGCGGTCCTGAGAGCCTCC 
                   
               
               
                   
                 TGGGCATGTTTGTCTGTGTGCTGTAACCTGAAGTCAAACCTTAAGATAAT 
                   
               
               
                   
                 GGATAATCTTCGGCCAATTTATGCAGAGTCAGCCATTCCTGTTCTCTTTGC 
                   
               
               
                   
                 CTTGATGTTGTGTTGTTATCATTTAAGATTTTTTTTTTTTGGTAATTATTTT 
                   
               
               
                   
                 GAGTGGCAAAATAAAGAATAGCAATTA 
                   
               
               
                   
               
               
                 PLOD 
                 CCACCATATCGGTCCCGTATTTCACATTGATAAGGTCCTGTTTCATTTCTC 
                 202 
               
               
                 L06419.1 
                 GTGACATTGGGTAGAATGAGGATCCTGTTTTCAATGGGTCGCTTTACCCTG 
                   
               
               
                   
                 GGACTGACAGGGAGGCTCTGACCATTTAGCCACCAAATGTAGGTGTAGTT 
                   
               
               
                   
                 CTCACTCTTAGGTTCACCCCGCGGCCGATCGTCCCCCATACCTCGGCCATG 
                   
               
               
                   
                 CGGCCCCTGCTGCTACTGGCCCTGCTGGGCTGGCTGCTGCTGGCCGAAGC 
                   
               
               
                   
                 GAAGGGCGACGCCAAGCCGGAGGACAACCTTTTAGTCCTCACGGTGGCC 
                   
               
               
                   
                 ACTAAGGAGACCGAGGGATTCCGTCGCTTCAAGCGCTCAGCTCAGTTCTT 
                   
               
               
                   
                 CAACTACAAGATCCAGGCGCTTGGCCTAGGGGAGGACTGGAATGTGGAG 
                   
               
               
                   
                 AAGGGGACGTCGGCAGGTGGAGGGCAGAAGGTCCGGCTGCTGAAGAAAG 
                   
               
               
                   
                 CTCTGGAGAAGCACGCAGACAAGGAGGATCTGGTCATTCTCTTCACAGAC 
                   
               
               
                   
                 AGCTATGACGTGCTGTTTGCATCGGGGCCCCGGGAGCTCCTGAAGAAGTT 
                   
               
               
                   
                 CCGGCAGGCCAGGAGCCAGGTGGTCTTCTCTGCTGAGGAGCTCATCTACC 
                   
               
               
                   
                 CAGACCGCAGGCTGGAGACCAAGTATCCGGTGGTGTCCGATGGCAAGAG 
                   
               
               
                   
                 GTTCCTGGGCTCTGGAGGCTTCATCGGTTATGCCCCCAACCTCAGCAAACT 
                   
               
               
                   
                 GGTGGCCGAGTGGGAGGGCCAGGACAGCGACAGCGATCAGCTGTTTTAC 
                   
               
               
                   
                 ACCAAGATCTTCTTGGACCCGGAGAAGAGGGAGCAGATCAATATCACCCT 
                   
               
               
                   
                 GGACCACCGCTGCCGTATCTTCCAGAACCTGGATGGAGCCTTGGATGAGG 
                   
               
               
                   
                 TCGTGCTCAAGTTTGAAATGGGCCATGTGAGAGCGAGGAACCTGGCCTAT 
                   
               
               
                   
                 GACACCCTCCCGGTCCTGATCCATGGCAACGGGCCAACCAAGCTGCAGTT 
                   
               
               
                   
                 GAACTACCTGGGCAACTACATCCCGCGCTTCTGGACCTTCGAAACAGGCT 
                   
               
               
                   
                 GCACCGTGTGTGACGAAGGCTTGCGCAGCCTCAAGGGCATTGGGGATGA 
                   
               
               
                   
                 AGCTCTGCCCACGGTCCTGGTCGGCGTGTTCATCGAACAGCCCACGCCGT 
                   
               
               
                   
                 TTGTGTCCCTGTTCTTCCAGCGGCTCCTGCGGCTCCACTACCCCCAGAAAC 
                   
               
               
                   
                 ACATGCGACTTTTCATCCACAACCACGAGCAGCACCACAAGGCTCAGGTG 
                   
               
               
                   
                 GAAGAGTTCCTGGCACAGCATGGCAGCGAGTACCAGTCTGTGAAGCTGGT 
                   
               
               
                   
                 GGGCCCTGAGGTGCGGATGGCGAATGCAGATGCCAGGAACATGGGCGCA 
                   
               
               
                   
                 GACCTGTGCCGGCAGGACCGCAGCTGCACCTACTACTTCAGCGTGGATGC 
                   
               
               
                   
                 TGACGTGGCCCTGACCGAGCCCAACAGCCTGCGGCTGCTGATCCAACAGA 
                   
               
               
                   
                 ACAAGAATGTCATTGCCCCGCTGATGACCCGGCATGGGAGGCTGTGGTCG 
                   
               
               
                   
                 AACTTCTGGGGGGCTCTCAGTGCAGATGGCTACTATGCCCGTTCCGAGGA 
                   
               
               
                   
                 CTACGTGGACATTGTGCAGGGGCGGCGTGTTGGTGTCTGGAATGTGCCCT 
                   
               
               
                   
                 ATATTTCAAACATCTACTTGATCAAGGGCAGTGCCCTGCGGGGTGAGCTG 
                   
               
               
                   
                 CAGTCCTCAGATCTCTTCCACCACAGCAAGCTGGACCCCGACATGGCCTT 
                   
               
               
                   
                 CTGTGCCAACATCCGGCAGCAGGATGTGTTCATGTTCCTGACCAACCGGC 
                   
               
               
                   
                 ACACCCTTGGCCATCTGCTCTCCCTAGACAGCTACCGCACCACCCACCTGC 
                   
               
               
                   
                 ACAACGACCTCTGGGAGGTGTTCAGCAACCCCGAGGACTGGAAGGAGAA 
                   
               
               
                   
                 GTACATCCACCAGAACTACACCAAAGCCCTGGCAGGGAAGCTGGTGGAG 
                   
               
               
                   
                 ACGCCCTGCCCGGATGTCTATTGGTTCCCCATCTTCACGGAGGTGGCCTGT 
                   
               
               
                   
                 GATGAGCTGGTGGAGGAGATGGAGCACTTTGGCCAGTGGTCTCTGGGCAA 
                   
               
               
                   
                 CAACAAGGACAACCGCATCCAGGGTGGCTACGAGAACGTGCCGACTATT 
                   
               
               
                   
                 GACATCCACATGAACCAGATCGGCTTTGAGCGGGAGTGGCACAAATTCCT 
                   
               
               
                   
                 GCTGGAGTACATTGCGCCCATGACGGAGAAGCTCTACCCCGGCTACTACA 
                   
               
               
                   
                 CCAGGGCCCAGTTTGACCTGGCCTTTGTCGTCCGCTACAAGCCTGATGAG 
                   
               
               
                   
                 CAGCCCTCACTGATGCCACACCATGATGCCTCCACCTTCACCATCAACATC 
                   
               
               
                   
                 GCCCTGAACCGAGTCGGGGTGGATTACGAGGGCGGGGGCTGTCGGTTCCT 
                   
               
               
                   
                 GCGCTACAACTGTTCCATCCGAGCCCCAAGGAAGGGCTGGACCCTCATGC 
                   
               
               
                   
                 ACCCTGGACGACTCACGCATTACCATGAGGGGCTCCCCACCACCAGGGGC 
                   
               
               
                   
                 ACCCGCTACATCGCAGTCTCCTTCGTCGATCCCTAATTGGCCAGGCCTGAC 
                   
               
               
                   
                 CCTCTTGGACCTTTCTTCTTTGCCGACAACCACTGCCCAGCAGCCTCTGGG 
                   
               
               
                   
                 ACCTCGGGGTCCCAGGGAACCCAGTCCAGCCTCCTGGCTGTTGACTTCCC 
                   
               
               
                   
                 ATTGCTCTTGGAGCCACCAATCAAAGAGATTCAAAGAGATTCCTGCAGGC 
                   
               
               
                   
                 CAGAGGCCGGAACACACCTTTATGGCTGGGGCTCTCCGTGGTGTTCTGGA 
                   
               
               
                   
                 CCCAGCCCCTGGAGACACCATTCACTTTTACTGCTTTGTAGTGACTCGTGC 
                   
               
               
                   
                 TCTCCAACCTGTCTTCCTGAAAAACCAAGGCCCCCTTCCCCCACCTCTTCC 
                   
               
               
                   
                 ATGGGGTGAGACTTGAGCAGAACAGGGGCTTCCCCAAGTTGCCCAGAAA 
                   
               
               
                   
                 GACTGTCTGGGTGAGAAGCCATGGCCAGAGCTTCTCCCAGGCACAGGTGT 
                   
               
               
                   
                 TGCACCAGGGACTTCTGCTTCAAGTTTTGGGGTAAAGACACCTGGATCAG 
                   
               
               
                   
                 ACTCCAAGGGCTGCCCTGAGTCTGGGACTTCTGCCTCCATGGCTGGTCAT 
                   
               
               
                   
                 GAGAGCAAACCGTAGTCCCCTGGAGACAGCCACTCCAGAGAACCTCTTGG 
                   
               
               
                   
                 GAGACAGAAGAGGCATCTGTGCACAGCTCGATCTTCTACTTGCCTGTGGG 
                   
               
               
                   
                 GAGGGGAGTGACAGGTCCACACACCACACTGGGTCACCCTGTCCTGGATG 
                   
               
               
                   
                 CCTCTGAAGAGAGGGACAGACCGTCAGAAACTGGAGAGTTTCTATTAAA 
                   
               
               
                   
                 GGTCATTTAAACCAC 
                   
               
               
                   
               
               
                 DDIT4 
                 AGGGCGCAGCAGGCCAAGGGGGAGGTGCGAGCGTGGACCTGGGACGGGT 
                 203 
               
               
                 NM_019058.2 
                 CTGGGCGGCTCTCGGTGGTTGGCACGGGTTCGCACACCCATTCAAGCGGC 
                   
               
               
                   
                 AGGACGCACTTGTCTTAGCAGTTCTCGCTGACCGCGCTAGCTGCGGCTTCT 
                   
               
               
                   
                 ACGCTCCGGCACTCTGAGTTCATCAGCAAACGCCCTGGCGTCTGTCCTCA 
                   
               
               
                   
                 CCATGCCTAGCCTTTGGGACCGCTTCTCGTCGTCGTCCACCTCCTCTTCGC 
                   
               
               
                   
                 CCTCGTCCTTGCCCCGAACTCCCACCCCAGATCGGCCGCCGCGCTCAGCCT 
                   
               
               
                   
                 GGGGGTCGGCGACCCGGGAGGAGGGGTTTGACCGCTCCACGAGCCTGGA 
                   
               
               
                   
                 GAGCTCGGACTGCGAGTCCCTGGACAGCAGCAACAGTGGCTTCGGGCCG 
                   
               
               
                   
                 GAGGAAGACACGGCTTACCTGGATGGGGTGTCGTTGCCCGACTTCGAGCT 
                   
               
               
                   
                 GCTCAGTGACCCTGAGGATGAACACTTGTGTGCCAACCTGATGCAGCTGC 
                   
               
               
                   
                 TGCAGGAGAGCCTGGCCCAGGCGCGGCTGGGCTCTCGACGCCCTGCGCGC 
                   
               
               
                   
                 CTGCTGATGCCTAGCCAGTTGGTAAGCCAGGTGGGCAAAGAACTACTGCG 
                   
               
               
                   
                 CCTGGCCTACAGCGAGCCGTGCGGCCTGCGGGGGGCGCTGCTGGACGTCT 
                   
               
               
                   
                 GCGTGGAGCAGGGCAAGAGCTGCCACAGCGTGGGCCAGCTGGCACTCGA 
                   
               
               
                   
                 CCCCAGCCTGGTGCCCACCTTCCAGCTGACCCTCGTGCTGCGCCTGGACTC 
                   
               
               
                   
                 ACGACTCTGGCCCAAGATCCAGGGGCTGTTTAGCTCCGCCAACTCTCCCTT 
                   
               
               
                   
                 CCTCCCTGGCTTCAGCCAGTCCCTGACGCTGAGCACTGGCTTCCGAGTCAT 
                   
               
               
                   
                 CAAGAAGAAGCTGTACAGCTCGGAACAGCTGCTCATTGAGGAGTGTTGA 
                   
               
               
                   
                 ACTTCAACCTGAGGGGGCCGACAGTGCCCTCCAAGACAGAGACGACTGA 
                   
               
               
                   
                 ACTTTTGGGGTGGAGACTAGAGGCAGGAGCTGAGGGACTGATTCCTGTGG 
                   
               
               
                   
                 TTGGAAAACTGAGGCAGCCACCTAAGGTGGAGGTGGGGGAATAGTGTTT 
                   
               
               
                   
                 CCCAGGAAGCTCATTGAGTTGTGTGCGGGTGGCTGTGCATTGGGGACACA 
                   
               
               
                   
                 TACCCCTCAGTACTGTAGCATGAAACAAAGGCTTAGGGGCCAACAAGGCT 
                   
               
               
                   
                 TCCAGCTGGATGTGTGTGTAGCATGTACCTTATTATTTTTGTTACTGACAG 
                   
               
               
                   
                 TTAACAGTGGTGTGACATCCAGAGAGCAGCTGGGCTGCTCCCGCCCCAGC 
                   
               
               
                   
                 CCGGCCCAGGGTGAAGGAAGAGGCACGTGCTCCTCAGAGCAGCCGGAGG 
                   
               
               
                   
                 GAGGGGGGAGGTCGGAGGTCGTGGAGGTGGTTTGTGTATCTTACTGGTCT 
                   
               
               
                   
                 GAAGGGACCAAGTGTGTTTGTTGTTTGTTTTGTATCTTGTTTTTCTGATCG 
                   
               
               
                   
                 GAGCATCACTACTGACCTGTTGTAGGCAGCTATCTTACAGACGCATGAAT 
                   
               
               
                   
                 GTAAGAGTAGGAAGGGGTGGGTGTCAGGGATCACTTGGGATCTTTGACAC 
                   
               
               
                   
                 TTGAAAAATTACACCTGGCAGCTGCGTTTAAGCCTTCCCCCATCGTGTACT 
                   
               
               
                   
                 GCAGAGTTGAGCTGGCAGGGGAGGGGCTGAGAGGGTGGGGGCTGGAACC 
                   
               
               
                   
                 CCTCCCCGGGAGGAGTGCCATCTGGGTCTTCCATCTAGAACTGTTTACATG 
                   
               
               
                   
                 AAGATAAGATACTCACTGTTCATGAATACACTTGATGTTCAAGTATTAAG 
                   
               
               
                   
                 ACCTATGCAATATTTTTTACTTTTCTAATAAACATGTTTGTTAAAACAGTT 
                   
               
               
                   
               
               
                 VEGF 
                 TCGGGCCTCCGAAACCATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCT 
                 204 
               
               
                 AY047581.1 
                 TGCCTTGCTGCTCTACCTCCACCATGCCAAGTGGTCCCAGGCTGCACCCAT 
                   
               
               
                   
                 GGCAGAAGGAGGGGGGCAGAATCATCACGAAGTGGTGAAGTTCATGGAT 
                   
               
               
                   
                 GTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGACATCTT 
                   
               
               
                   
                 CCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGC 
                   
               
               
                   
                 CCCTGATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTG 
                   
               
               
                   
                 CCCACTGAGGAGTCCAACATCACCATGCAGATTATGCGGATCAAACCTCA 
                   
               
               
                   
                 CCAAGGCCAGCACATAGGAGAGATGAGCTTCCTACAGCACAACAAATGT 
                   
               
               
                   
                 GAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAAAATCCCTGTGGGC 
                   
               
               
                   
                 CTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAGACGTGT 
                   
               
               
                   
                 AAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGA 
                   
               
               
                   
                 GTTAAACGAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGAGCCGGG 
                   
               
               
                   
                 CAGGAGGAAGGAGCCTCCCTCAGGGTTTCGGGAACCAGATCT 
                   
               
               
                   
               
               
                 ADM 
                 CTGGATAGAACAGCTCAAGCCTTGCCACTTCGGGCTTCTCACTGCAGCTG 
                 205 
               
               
                 NM_001124.1 
                 GGCTTGGACTTCGGAGTTTTGCCATTGCCAGTGGGACGTCTGAGACTTTCT 
                   
               
               
                   
                 CCTTCAAGTACTTGGCAGATCACTCTCTTAGCAGGGTCTGCGCTTCGCAGC 
                   
               
               
                   
                 CGGGATGAAGCTGGTTTCCGTCGCCCTGATGTACCTGGGTTCGCTCGCCTT 
                   
               
               
                   
                 CCTAGGCGCTGACACCGCTCGGTTGGATGTCGCGTCGGAGTTTCGAAAGA 
                   
               
               
                   
                 AGTGGAATAAGTGGGCTCTGAGTCGTGGGAAGAGGGAACTGCGGATGTC 
                   
               
               
                   
                 CAGCAGCTACCCCACCGGGCTCGCTGACGTGAAGGCCGGGCCTGCCCAGA 
                   
               
               
                   
                 CCCTTATTCGGCCCCAGGACATGAAGGGTGCCTCTCGAAGCCCCGAAGAC 
                   
               
               
                   
                 AGCAGTCCGGATGCCGCCCGCATCCGAGTCAAGCGCTACCGCCAGAGCAT 
                   
               
               
                   
                 GAACAACTTCCAGGGCCTCCGGAGCTTTGGCTGCCGCTTCGGGACGTGCA 
                   
               
               
                   
                 CGGTGCAGAAGCTGGCACACCAGATCTACCAGTTCACAGATAAGGACAA 
                   
               
               
                   
                 GGACAACGTCGCCCCCAGGAGCAAGATCAGCCCCCAGGGCTACGGCCGC 
                   
               
               
                   
                 CGGCGCCGGCGCTCCCTGCCCGAGGCCGGCCCGGGTCGGACTCTGGTGTC 
                   
               
               
                   
                 TTCTAAGCCACAAGCACACGGGGCTCCAGCCCCCCCGAGTGGAAGTGCTC 
                   
               
               
                   
                 CCCACTTTCTTTAGGATTTAGGCGCCCATGGTACAAGGAATAGTCGCGCA 
                   
               
               
                   
                 AGCATCCCGCTGGTGCCTCCCGGGACGAAGGACTTCCCGAGCGGTGTGGG 
                   
               
               
                   
                 GACCGGGCTCTGACAGCCCTGCGGAGACCCTGAGTCCGGGAGGCACCGTC 
                   
               
               
                   
                 CGGCGGCGAGCTCTGGCTTTGCAAGGGCCCCTCCTTCTGGGGGCTTCGCTT 
                   
               
               
                   
                 CCTTAGCCTTGCTCAGGTGCAAGTGCCCCAGGGGGCGGGGTGCAGAAGA 
                   
               
               
                   
                 ATCCGAGTGTTTGCCAGGCTTAAGGAGAGGAGAAACTGAGAAATGAATG 
                   
               
               
                   
                 CTGAGACCCCCGGAGCAGGGGTCTGAGCCACAGCCGTGCTCGCCCACAA 
                   
               
               
                   
                 ACTGATTTCTCACGGCGTGTCACCCCACCAGGGCGCAAGCCTCACTATTA 
                   
               
               
                   
                 CTTGAACTTTCCAAAACCTAAAGAGGAAAAGTGCAATGCGTGTTGTACAT 
                   
               
               
                   
                 ACAGAGGTAACTATCAATATTTAAGTTTGTTGCTGTCAAGATTTTTTTTGT 
                   
               
               
                   
                 AACTTCAAATATAGAGATATTTTTGTACGTTATATATTGTATTAAGGGCAT 
                   
               
               
                   
                 TTTAAAAGCAATTATATTGTCCTCCCCTATTTTAAGACGTGAATGTCTCAG 
                   
               
               
                   
                 CGAGGTGTAAAGTTGTTCGCCGCGTGGAATGTGAGTGTGTTTGTGTGCAT 
                   
               
               
                   
                 GAAAGAGAAAGACTGATTACCTCCTGTGTGGAAGAAGGAAACACCGAGT 
                   
               
               
                   
                 CTCTGTATAATCTATTTACATAAAATGGGTGATATGCGAACAGCAAACC 
                   
               
               
                   
               
               
                 ANGPTL4 
                 GACTGTGATCCGATTCTTTCCAGCGGCTTCTGCAACCAAGCGGGTCTTACC 
                 206 
               
               
                 BCO23647.2 
                 CCCGGTCCTCCGCGTCTCCAGTCCTCGCACCTGGAACCCCAACGTCCCCG 
                   
               
               
                   
                 AGAGTCCCCGAATCCCCGCTCCCAGGCTACCTAAGAGGATGAGCGGTGCT 
                   
               
               
                   
                 CCGACGGCCGGGGCAGCCCTGATGCTCTGCGCCGCCACCGCCGTGCTACT 
                   
               
               
                   
                 GAGCGCTCAGGGCGGACCCGTGCAGTCCAAGTCGCCGCGCTTTGCGTCCT 
                   
               
               
                   
                 GGGACGAGATGAATGTCCTGGCGCACGGACTCCTGCAGCTCGGCCAGGG 
                   
               
               
                   
                 GCTGCGCGAACACGCGGAGCGCACCCGCAGTCAGCTGAGCGCGCTGGAG 
                   
               
               
                   
                 CGGCGCCTGAGCGCGTGCGGGTCCGCCTGTCAGGGAACCGAGGGGTCCA 
                   
               
               
                   
                 CCGACCTCCCGTTAGCCCCTGAGAGCCGGGTGGACCCTGAGGTCCTTCAC 
                   
               
               
                   
                 AGCCTGCAGACACAACTCAAGGCTCAGAACAGCAGGATCCAGCAACTCTT 
                   
               
               
                   
                 CCACAAGGTGGCCCAGCAGCAGCGGCACCTGGAGAAGCAGCACCTGCGA 
                   
               
               
                   
                 ATTCAGCATCTGCAAAGCCAGTTTGGCCTCCTGGACCACAAGCACCTAGA 
                   
               
               
                   
                 CCATGAGGTGGCCAAGCCTGCCCGAAGAAAGAGGCTGCCCGAGATGGCC 
                   
               
               
                   
                 CAGCCAGTTGACCCGGCTCACAATGTCAGCCGCCTGCACCGGCTGCCCAG 
                   
               
               
                   
                 GGATTGCCAGGAGCTGTTCCAGGTTGGGGAGAGGCAGAGTGGACTATTTG 
                   
               
               
                   
                 AAATCCAGCCTCAGGGGTCTCCGCCATTTTTGGTGAACTGCAAGATGACC 
                   
               
               
                   
                 TCAGATGGAGGCTGGACAGTAATTCAGAGGCGCCACGATGGCTCAGTGG 
                   
               
               
                   
                 ACTTCAACCGGCCCTGGGAAGCCTACAAGGCGGGGTTTGGGGATCCCCAC 
                   
               
               
                   
                 GGCGAGTTCTGGCTGGGTCTGGAGAAGGTGCATAGCATCACGGGGGACC 
                   
               
               
                   
                 GCAACAGCCGCCTGGCCGTGCAGCTGCGGGACTGGGATGGCAACGCCGA 
                   
               
               
                   
                 GTTGCTGCAGTTCTCCGTGCACCTGGGTGGCGAGGACACGGCCTATAGCC 
                   
               
               
                   
                 TGCAGCTCACTGCACCCGTGGCCGGCCAGCTGGGCGCCACCACCGTCCCA 
                   
               
               
                   
                 CCCAGCGGCCTCTCCGTACCCTTCTCCACTTGGGACCAGGATCACGACCTC 
                   
               
               
                   
                 CGCAGGGACAAGAACTGCGCCAAGAGCCTCTCTGGAGGCTGGTGGTTTGG 
                   
               
               
                   
                 CACCTGCAGCCATTCCAACCTCAACGGCCAGTACTTCCGCTCCATCCCAC 
                   
               
               
                   
                 AGCAGCGGCAGAAGCTTAAGAAGGGAATCTTCTGGAAGACCTGGCGGGG 
                   
               
               
                   
                 CCGCTACTACCCACTGCAGGCCACCACCATGTTGATCCAGCCCATGGCAG 
                   
               
               
                   
                 CAGAGGCAGCCTCCTAGCGTCCTGGCTGGGCCTGGTCCCAGGCCCACGAA 
                   
               
               
                   
                 AGACGGTGACTCTTGGCTCTGCCCGAGGATGTGGCCGTTCCCTGCCTGGG 
                   
               
               
                   
                 CAGGGGCTCCAAGGAGGGGCCATCTGGAAACTTGTGGACAGAGAAGAAG 
                   
               
               
                   
                 ACCACGACTGGAGAAGCCCCCTTTCTGAGTGCAGGGGGGCTGCATGCGTT 
                   
               
               
                   
                 GCCTCCTGAGATCGAGGCTGCAGGATATGCTCAGACTCTAGAGGCGTGGA 
                   
               
               
                   
                 CCAAGGGGCATGGAGCTTCACTCCTTGCTGGCCAGGGAGTTGGGGACTCA 
                   
               
               
                   
                 GAGGGACCACTTGGGGCCAGCCAGACTGGCCTCAATGGCGGACTCAGTC 
                   
               
               
                   
                 ACATTGACTGACGGGGACCAGGGCTTGTGTGGGTCGAGAGCGCCCTCATG 
                   
               
               
                   
                 GTGCTGGTGCTGTTGTGTGTAGGTCCCCTGGGGACACAAGCAGGCGCCAA 
                   
               
               
                   
                 TGGTATCTGGGCGGAGCTCACAGAGTTCTTGGAATAAAAGCAACCTCAGA 
                   
               
               
                   
                 AAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 NDRG1 
                 ATGTCTCGGGAGATGCAGGATGTAGACCTCGCTGAGGTGAAGCCTTTGGT 
                 207 
               
               
                 CR456842.1 
                 GGAGAAAGGGGAGACCATCACCGGCCTCCTGCAAGAGTTTGATGTCCAG 
                   
               
               
                   
                 GAGCAGGACATCGAGACTTTACATGGCTCTGTTCACGTCACGCTGTGTGG 
                   
               
               
                   
                 GACTCCCAAGGGAAACCGGCCTGTCATCCTCACCTACCATGACATCGGCA 
                   
               
               
                   
                 TGAACCACAAAACCTGCTACAACCCCCTCTTCAACTACGAGGACATGCAG 
                   
               
               
                   
                 GAGATCACCCAGCACTTTGCCGTCTGCCACGTGGACGCCCCTGGCCAGCA 
                   
               
               
                   
                 GGACGGCGCAGCCTCCTTCCCCGCAGGGTACATGTACCCCTCCATGGATC 
                   
               
               
                   
                 AGCTGGCTGAAATGCTTCCTGGAGTCCTTCAACAGTTTGGGCTGAAAAGC 
                   
               
               
                   
                 ATTATTGGCATGGGAACAGGAGCAGGCGCCTACATCCTAACTCGATTTGC 
                   
               
               
                   
                 TCTAAACAACCCTGAGATGGTGGAGGGCCTTGTCCTTATCAACGTGAACC 
                   
               
               
                   
                 CTTGTGCGGAAGGCTGGATGGACTGGGCCGCCTCCAAGATCTCAGGATGG 
                   
               
               
                   
                 ACCCAAGCTCTGCCGGACATGGTGGTGTCCCACCTTTTTGGGAAGGAAGA 
                   
               
               
                   
                 AATGCAGAGTAACGTGGAAGTGGTCCACACCTACCGCCAGCACATTGTGA 
                   
               
               
                   
                 ATGACATGAACCCCGGCAACCTGCACCTGTTCATCAATGCCTACAACAGC 
                   
               
               
                   
                 CGGCGCGACCTGGAGATTGAGCGACCAATGCCGGGAACCCACACAGTCA 
                   
               
               
                   
                 CCCTGCAGTGCCCTGCTCTGTTGGTGGTTGGGGACAGCTCGCCTGCAGTG 
                   
               
               
                   
                 GATGCCGTGGTGGAGTGCAACTCAAAATTGGACCCAACAAAGACCACTCT 
                   
               
               
                   
                 CCTCAAGATGGCGGACTGTGGCGGCCTCCCGCAGATCTCCCAGCCGGCCA 
                   
               
               
                   
                 AGCTCGCTGAGGCCTTCAAGTACTTCGTGCAGGGCATGGGATACATGCCC 
                   
               
               
                   
                 TCGGCTAGCATGACCCGCCTGATGCGGTCCCGCACAGCCTCTGGTTCCAG 
                   
               
               
                   
                 CGTCACTTCTCTGGATGGCACCCGCAGCCGCTCCCACACCAGCGAGGGCA 
                   
               
               
                   
                 CCCGAAGCCGCTCCCACACCAGCGAGGGCACCCGCAGCCGCTCGCACACC 
                   
               
               
                   
                 AGCGAGGGGGCCCACCTGGACATCACCCCCAACTCGGGTGCTGCTGGGA 
                   
               
               
                   
                 ACAGCGCCGGGCCCAAGTCCATGGAGGTCTCCTGTTAA 
                   
               
               
                   
               
               
                 NP 
                 ATAAGCCAGAGCCTAGACCAGTGAGCCAACTGTGCGAACCAGACCCGGC 
                 208 
               
               
                 NM_000270.3 
                 AGCCTTGCTCAGTTCAGCATAGCGGAGCGGATCCGATCGGATCGGAGCGG 
                   
               
               
                   
                 ATCGGAGCACACCGGAGCAGGCTCATCGAGAAGGCGTCTGCGAGACCAT 
                   
               
               
                   
                 GGAGAACGGATACACCTATGAAGATTATAAGAACACTGCAGAATGGCTT 
                   
               
               
                   
                 CTGTCTCACACTAAGCACCGACCTCAAGTTGCAATAATCTGTGGTTCTGG 
                   
               
               
                   
                 ATTAGGAGGTCTGACTGATAAATTAACTCAGGCCCAGATCTTTGACTACG 
                   
               
               
                   
                 GTGAAATCCCCAACTTTCCCCGAAGTACAGTGCCAGGTCATGCTGGCCGA 
                   
               
               
                   
                 CTGGTGTTTGGGTTCCTGAATGGCAGGGCCTGTGTGATGATGCAGGGCAG 
                   
               
               
                   
                 GTTCCACATGTATGAAGGGTACCCACTCTGGAAGGTGACATTCCCAGTGA 
                   
               
               
                   
                 GGGTTTTCCACCTTCTGGGTGTGGACACCCTGGTAGTCACCAATGCAGCA 
                   
               
               
                   
                 GGAGGGCTGAACCCCAAGTTTGAGGTTGGAGATATCATGCTGATCCGTGA 
                   
               
               
                   
                 CCATATCAACCTACCTGGTTTCAGTGGTCAGAACCCTCTCAGAGGGCCCA 
                   
               
               
                   
                 ATGATGAAAGGTTTGGAGATCGTTTCCCTGCCATGTCTGATGCCTACGAC 
                   
               
               
                   
                 CGGACTATGAGGCAGAGGGCTCTCAGTACCTGGAAACAAATGGGGGAGC 
                   
               
               
                   
                 AACGTGAGCTACAGGAAGGCACCTATGTGATGGTGGCAGGCCCCAGCTTT 
                   
               
               
                   
                 GAGACTGTGGCAGAATGTCGTGTGCTGCAGAAGCTGGGAGCAGACGCTG 
                   
               
               
                   
                 TTGGCATGAGTACAGTACCAGAAGTTATCGTTGCACGGCACTGTGGACTT 
                   
               
               
                   
                 CGAGTCTTTGGCTTCTCACTCATCACTAACAAGGTCATCATGGATTATGAA 
                   
               
               
                   
                 AGCCTGGAGAAGGCCAACCATGAAGAAGTCTTAGCAGCTGGCAAACAAG 
                   
               
               
                   
                 CTGCACAGAAATTGGAACAGTTTGTCTCCATTCTTATGGCCAGCATTCCAC 
                   
               
               
                   
                 TCCCTGACAAAGCCAGTTGACCTGCCTTGGAGTCGTCTGGCATCTCCCAC 
                   
               
               
                   
                 ACAAGACCCAAGTAGCTGCTACCTTCTTTGGCCCCTTGCTGGAGTCATGTG 
                   
               
               
                   
                 CCTCTGTCCTTAGGTTGTAGCAGAAAGGAAAAGATTCCTGTCCTTCACCTT 
                   
               
               
                   
                 TCCCACTTTCTTCTACCAGACCCTTCTGGTGCCAGATCCTCTTCTCAAAGC 
                   
               
               
                   
                 TGGGATTACAGGTGTGAGCATAGTGAGACCTTGGCGCTACAAAATAAAGC 
                   
               
               
                   
                 TGTTCTCATTCCTGTTCTTTCTTACACAAGAGCTGGAGCCCGTGCCCTACC 
                   
               
               
                   
                 ACACATCTGTGGAGATGCCCAGGATTTGACTCGGGCCTTAGAACTTTGCA 
                   
               
               
                   
                 TAGCAGCTGCTACTAGCTCTTTGAGATAATACATTCCGAGGGGCTCAGTT 
                   
               
               
                   
                 CTGCCTTATCTAAATCACCAGAGACCAAACAAGGACTAATCCAATACCTC 
                   
               
               
                   
                 TTGGATTTTATTTAATGTCATAATGTTGTCAGAATAAAGAGAAAGATGAA 
                   
               
               
                   
                 ATAATTTCATTTTTTTGTGTAACTTGGTATGGGGCTGGGGCACAGACCAAG 
                   
               
               
                   
                 ATTGACATGAAAGGATGTGAGATCGCATGTCTTGTGTGACTATCTGCTTCT 
                   
               
               
                   
                 CAGACAAGCAGTTAGGAACTGAGATGAGATAGTATGTGAGGGCAGCAAA 
                   
               
               
                   
                 GGATGAAGAAGGGCAAAATGATGAAAGGTGAGGTGGAAAGAGGTTATGA 
                   
               
               
                   
                 GATGGTAAAGAAAAGTTAACTTCTGGCACTTGATTGCCACTTCTGTCAGG 
                   
               
               
                   
                 CTGGTCCTGCCTCTCTCCCTTGCCTTCTGATTGTTTCATTTCCTGTTTATTT 
                   
               
               
                   
                 GATCATATCTGAATTAGTTCACTGGTTAGCCTCTTCCTTAGTTCCCACTTC 
                   
               
               
                   
                 CTTACCAAAGCCCTAATTATATTTCCTCTTGTTTGCCTTTTCTCTCCTACTC 
                   
               
               
                   
                 TTCTCTAACATCTGCAGCCACACTCTCCATTCACTCCATGCTGACAAGGCA 
                   
               
               
                   
                 GTGGCAAACACTTTTCTCTGCTGCCAGCCACTCCACTGTTGACTGGATTGC 
                   
               
               
                   
                 TGCCAGCCCCAGGCAAACCTGTGAAGTTGTTTCATACTCTGCTTCTCTTTG 
                   
               
               
                   
                 AGTGCCTCCTTCTCTCCTTCCTCTTCCTTTCTGGGCTCCAGTCTTTCTCTTC 
                   
               
               
                   
                 ACTTGTGCTTGTCAGAACCTCCCTGTGATACTGCCTCCAGGCATTTCCCCC 
                   
               
               
                   
                 ATGTTGGCTCACCGCACTATTATCTTTGCTTATCAACTTGCATTCAGCTGG 
                   
               
               
                   
                 CTGGCATGTTTCAAAACCACACTGCCCTCCCAGGCCTGTGTGCCTTTTGAG 
                   
               
               
                   
                 AAAGACCAGTGCTGGATGAGCCTCTAGTAATGACAACATTTTAGTTGTTA 
                   
               
               
                   
                 GTGGTATAATACGGAAGAGATATTTTGCACAGGCTGCTTTGGAGAACTTT 
                   
               
               
                   
                 CAAATTATCCTTTGTTTGGTAACTGACCTACTTAACTGCCCAATACAAAGA 
                   
               
               
                   
                 AAAAGCAAAAAAAAAAAAAAAAAA 
                   
               
               
                   
               
               
                 SLC16A3 
                 GAATTCGCCCTTCAGGTGAGGCGGAACCAACCCTCCTGGCCATGGGAGGG 
                 209 
               
               
                 BC112269.1 
                 GCCGTGGTGGACGAGGGCCCCACAGGCGTCAAGGCCCCTGACGGCGGCT 
                   
               
               
                   
                 GGGGCTGGGCCGTGCTCTTCGGCTGTTTCGTCATCACTGGCTTCTCCTACG 
                   
               
               
                   
                 CCTTCCCCAAGGCCGTCAGTGTCTTCTTCAAGGAGCTCATACAGGAGTTTG 
                   
               
               
                   
                 GGATCGGCTACAGCGACACAGCCTGGATCTCCTCCATCCTGCTGGCCATG 
                   
               
               
                   
                 CTCTACGGGACAGGTCCGCTCTGCAGTGTGTGCGTGAACCGCTTTGGCTG 
                   
               
               
                   
                 CCGGCCCGTCATGCTTGTGGGGGGTCTCTTTGCGTCGCTGGGCATGGTGG 
                   
               
               
                   
                 CTGCGTCCTTTTGCCGGAGCATCATCCAGGTCTACCTCACCACTGGGGTCA 
                   
               
               
                   
                 TCACGGGGTTGGGTTTGGCACTCAACTTCCAGCCCTCGCTCATCATGCTGA 
                   
               
               
                   
                 ACCGCTACTTCAGCAAGCGGCGCCCCATGGCCAACGGGCTGGCGGCAGC 
                   
               
               
                   
                 AGGTAGCCCTGTCTTCCTGTGTGCCCTGAGCCCGCTGGGGCAGCTGCTGC 
                   
               
               
                   
                 AGGACCGCTACGGCTGGCGGGGCGGCTTCCTCATCCTGGGCGGCCTGCTG 
                   
               
               
                   
                 CTCAACTGCTGCGTGTGTGCCGCACTCATGAGGCCCCTGGTGGTCACGGC 
                   
               
               
                   
                 CCAGCCGGGCTCGGGGCCGCCGCGACCCTCCCGGCGCCTGCTAGACCTGA 
                   
               
               
                   
                 GCGTCTTCCGGGACCGCGGCTTTGTGCTTTACGCCGTGGCCGCCTCGGTCA 
                   
               
               
                   
                 TGGTGCTGGGGCTCTTCGTCCCGCCCGTGTTCGTGGTGAGCTACGCCAAG 
                   
               
               
                   
                 GACCTGGGCGTGCCCGACACCAAGGCCGCCTTCCTGCTCACCATCCTGGG 
                   
               
               
                   
                 CTTCATTGACATCTTCGCGCGGCCGGCCGCGGGCTTCGTGGCGGGGCTTG 
                   
               
               
                   
                 GGAAGGTGCGGCCCTACTCCGTCTACCTCTTCAGCTTCTCCATGTTCTTCA 
                   
               
               
                   
                 ACGGCCTCGCGGACCTGGCGGGCTCTACGGCGGGCGACTACGGCGGCCTC 
                   
               
               
                   
                 GTGGTCTTCTGCATCTTCTTTGGCATCTCCTACGGCATGGTGGGGGCCCTG 
                   
               
               
                   
                 CAGTTCGAGGTGCTCATGGCCATCGTGGGCACCCACAAGTTCTCCAGTGC 
                   
               
               
                   
                 CATTGGCCTGGTGCTGCTGATGGAGGCGGTGGCCGTGCTCGTCGGGCCCC 
                   
               
               
                   
                 CTTCGGGAGGCAAACTCCTGGATGCGACCCACGTCTACATGTACGTGTTC 
                   
               
               
                   
                 ATCCTGGCGGGGGCCGAGGTGCTCACCTCCTCCCTGATTTTGCTGCTGGGC 
                   
               
               
                   
                 AACTTCTTCTGCATTAGGAAGAAGCCCAAAGAGCCACAGCCTGAGGTGGC 
                   
               
               
                   
                 GGCCGCGGAGGAGGAGAAGCTCCACAAGCCTCCTGCAGACTCGGGGGTG 
                   
               
               
                   
                 GACTTGCGGGAGGTGGAGCATTTCCTGAAGGCTGAGCCTGAGAAAAACG 
                   
               
               
                   
                 GGGAGGTGGTTCACACCCCGGAAACAAGTGTCTGAGTGGCTGGGCGGGG 
                   
               
               
                   
                 CCGGCAGGCACAGGGAGGAGGTACAGAAGCCGGCAACGCTTGCTATTTA 
                   
               
               
                   
                 TTTTACAAACTGGACTGGCTCAGGCAGGGCCACGGCTGGGCTCCAGCTGC 
                   
               
               
                   
                 CGGCCCAGCGGATCGTCGCCCGATCAGTGTTTTGAG 
                   
               
               
                   
               
               
                 C14ORF58 
                 GCGAGGCCCCAAGCTGGCCCGGGAGAGGACTCTGCGGGCGAAGTGGCTG 
                 210 
               
               
                 NM_017791.2 
                 CGCAAGGAGAGAACTTTTCCTGCACAAGGAACGCCTCGTGGGGAGACCC 
                   
               
               
                   
                 AAGGCAGGAGCGGTCCGGAGCCGGCTGCGGCGTGTGCGGCCGGCCTTGG 
                   
               
               
                   
                 GACAGCGATCGCCGCGGGTGGCAACAGAGAGCCCCAAGCAAAAGTGGGA 
                   
               
               
                   
                 GCAGGAGCTTGGAGGTGAGCACAGGAAGCCCCACTTGAGGCTTTTACGCA 
                   
               
               
                   
                 GCCTCTAGTCTCTGTTTCTTCTGGAATAGGCAAGTGTCCTTTCAACTCTAA 
                   
               
               
                   
                 GAGACCAGCAGAGGCCACTGTCCCTTAAGACTGCCGGAGTCCTCACCACT 
                   
               
               
                   
                 TCTCCAGGATTCCAGAGGAGACTGTGGCGATGGTGAATGAAGGTCCCAAC 
                   
               
               
                   
                 CAGGAAGAGAGCGATGACACCCCTGTGCCGGAGTCCGCACTCCAAGCGG 
                   
               
               
                   
                 ACCCCAGCGTCTCGGTCCATCCCAGCGTCTCGGTCCATCCCAGCGTCTCCA 
                   
               
               
                   
                 TCAACCCCAGCGTCTCTGTCCACCCCAGCAGTTCGGCCCACCCCAGTGCCT 
                   
               
               
                   
                 TAGCCCAACCCAGTGGCTTGGCTCACCCCAGTAGCTCGGGCCCTGAGGAC 
                   
               
               
                   
                 CTCAGCGTGATCAAGGTGAGCAGGCGCCGTTGGGCCGTGGTCCTGGTGTT 
                   
               
               
                   
                 TAGCTGCTACTCCATGTGCAACTCCTTTCAGTGGATCCAGTACGGCTCCAT 
                   
               
               
                   
                 CAATAACATCTTCATGCACTTCTACGGTGTCAGTGCCTTTGCCATTGACTG 
                   
               
               
                   
                 GCTGTCCATGTGCTACATGCTGACTTACATCCCTCTGCTCCTGCCAGTGGC 
                   
               
               
                   
                 TTGGCTGCTGGAGAAGTTCGGCCTGCGCACCATTGCTCTCACTGGCTCGG 
                   
               
               
                   
                 CTCTCAACTGCCTGGGGGCCTGGGTGAAGCTGGGCAGCCTGAAGCCGCAT 
                   
               
               
                   
                 CTCTTTCCGGTCACCGTGGTGGGCCAGCTCATCTGCTCTGTGGCCCAGGTT 
                   
               
               
                   
                 TTCATCCTGGGCATGCCCTCCCGCATCGCTTCCGTCTGGTTCGGGGCTAAT 
                   
               
               
                   
                 GAGGTTTCAACAGCCTGCTCCGTGGCTGTCTTTGGCAATCAGCTTGGAATT 
                   
               
               
                   
                 GCGATTGGGTTCTTGGTCCCTCCTGTTTTGGTACCCAACATTGAAGACCGG 
                   
               
               
                   
                 GACGAGCTTGCCTACCACATCAGCATCATGTTCTATATAATAGGAGGTGT 
                   
               
               
                   
                 GGCCACTCTCCTCCTCATCCTTGTCATCATTGTGTTCAAGGAGAAACCTAA 
                   
               
               
                   
                 ATATCCCCCCAGCAGGGCCCAATCCCTGAGCTATGCCTTGACCTCTCCTGA 
                   
               
               
                   
                 TGCCTCATACTTAGGTTCCATCGCCCGGCTCTTCAAAAATCTCAACTTTGT 
                   
               
               
                   
                 GCTGCTTGTCATCACCTATGGTCTGAATGCTGGTGCTTTTTATGCCTTGTC 
                   
               
               
                   
                 CACTCTTCTGAATCGCATGGTGATCTGGCACTACCCGGGGGAAGAAGTGA 
                   
               
               
                   
                 ATGCTGGAAGAATTGGCCTGACGATCGTCATTGCAGGAATGCTTGGGGCT 
                   
               
               
                   
                 GTGATCTCAGGAATCTGGCTGGATAGGTCCAAAACCTACAAAGAGACAA 
                   
               
               
                   
                 CCCTGGTAGTCTATATCATGACACTGGTGGGCATGGTGGTGTACACGTTT 
                   
               
               
                   
                 ACCTTGAACCTGGGACACCTGTGGGTAGTGTTCATCACTGCTGGCACAAT 
                   
               
               
                   
                 GGGCTTCTTTATGACTGGCTATCTCCCACTGGGATTTGAGTTTGCTGTGGA 
                   
               
               
                   
                 GCTCACGTACCCAGAATCAGAAGGCATCTCCTCCGGCCTCCTCAACATAT 
                   
               
               
                   
                 CTGCACAGGTATTTGGGATCATCTTTACCATCTCCCAGGGCCAGATTATTG 
                   
               
               
                   
                 ACAACTATGGAACCAAGCCTGGGAACATCTTCCTGTGTGTGTTCCTTACTC 
                   
               
               
                   
                 TTGGAGCAGCCCTCACTGCATTCATTAAGGCAGATCTCCGGAGACAGAAA 
                   
               
               
                   
                 GCAAACAAAGAAACTCTTGAGAACAAACTCCAAGAGGAGGAGGAGGAG 
                   
               
               
                   
                 AGCAACACCAGCAAAGTGCCCACTGCTGTGTCAGAGGATCATCTCTGAGA 
                   
               
               
                   
                 GGAAGGTGGTGACAACTCAGGGAACACGAACACCCCACCTTTTCCTTCAG 
                   
               
               
                   
                 CACAGCTCTCACCGCCAGCACAAAGGGCTTCGCTAGAGATGTTTTTGGAG 
                   
               
               
                   
                 GGAATCAGTGGGACTATTTGTGGCATGGATGGCCTATTCCTCCTAGAACC 
                   
               
               
                   
                 CACGTAAGAGCTTGGATGATTTAGTTGGAGAAAATTGCACCTATCACCAA 
                   
               
               
                   
                 ATGCAAATTTGATTCCCACCTCCACCCCCTTTTAGGTTATGGGAGTTGGTG 
                   
               
               
                   
                 TTGGGACAGGGTGGCAGAGAATATTGGAGTCAATCCTAGCTTGGTCTCTT 
                   
               
               
                   
                 GCCTTCCCTCTTTTCCTCCATCCATCGTGGACAATGCCTGCAAAATTTTCA 
                   
               
               
                   
                 CAGGAAGAAAGCCTATTCAGGATATTAACTTGAAATTTCCAGTGTCCTAA 
                   
               
               
                   
                 GAGCCTCTCATGAAGCCCAGTTCTAATAAGTGGCAAGCTGCTCTGCCGGG 
                   
               
               
                   
                 GTCATCTCCTGGGTCATCGGACTGATTGCTCAAGTTCTGCAGGAGAGGAA 
                   
               
               
                   
                 GCACCATTAGAACAACTCCATCAGAACAGCTCCACCGGGACTTGTGGGCC 
                   
               
               
                   
                 TAAATTTTCCTGGCCTAACGGGTCTGTCTCCAAACCCTCTTTCCTAAGAGC 
                   
               
               
                   
                 TGAGCAAACCAACCATAATAAACTTGACAAAAGACTTTGTTGTGGCCATG 
                   
               
               
                   
                 ACAGAGATACCGACTCAGGAGGGCTACCTACCTAGGTGTGATCATGCTGG 
                   
               
               
                   
                 GGGCTACCTTCTGAGTATATTTGTGAAAGCACATATTTGGGAACTCTGGT 
                   
               
               
                   
                 AGCTTGAGTTGGGAATGGGAAGGTTCTTTTTTACAGAAGTACTTCCCCAG 
                   
               
               
                   
                 GGACTTCTGTGTGTCACAGTCACCTCTGATGCCTTTATCTTGATGTTGCAT 
                   
               
               
                   
                 TGGGAATCTCAGCCATCAGCCCAAGTGCTTGTTTTATTCCAAGGCAGGGT 
                   
               
               
                   
                 AATCCCCGTCAACTTACTCTAACCTTTGCTGAAAACTAATCTTGATTCATT 
                   
               
               
                   
                 CTACTCTGAAAATCCAAAGGTGCTTCTGAGAGATAAGAGGGAAGGGGTA 
                   
               
               
                   
                 GAAGGAAAGGTGCCCCTTGAAATGGGAATTGAGCCTGTTAGAATTAAAA 
                   
               
               
                   
                 GCTTATCTCACCTCTGCTGGGGACAGTATTTGCACCACCAACCCCTCTCCT 
                   
               
               
                   
                 CACCTGCTTTGAGCGATAATCTTTATCAGATATTCTAAACTTAAAGGGATT 
                   
               
               
                   
                 CCCTTTAAACCAACTCAAGCTGATCTTTCCTATCTAGCCTGCTGTTTGGCT 
                   
               
               
                   
                 GTACTCATGGGCTTTGGTAATATCTCCTAAAAATGAGGTTTTGGTAATTTT 
                   
               
               
                   
                 TCCTATGCATTGGGCAACTGTGATCGTGACCACTGTGCTGTCTTGCTCCAG 
                   
               
               
                   
                 CCACTGCCCTGGCCTCAGCATATCAGGGCAGCCTGTGCTGGCTGCAATAC 
                   
               
               
                   
                 TGTGGTGCTTGGGCCACTGCCTGAGAGGAGCCAGGTTTGTGTGTGTCTGC 
                   
               
               
                   
                 ATGTGTGTGTGTGTGTGTTTGTACAGATTCAAGCAATGGATGCAAGGAAC 
                   
               
               
                   
                 ATGCTGTATGTAATAGAAGAAAGAAGTCCACGTTTTCGGCAGAAGTAGTG 
                   
               
               
                   
                 AGTCAGTGTGGAAGAGAGGTGAGGGTGTGCTTTACTTTTTGATAAAGAGA 
                   
               
               
                   
                 AAGATGTTTACTCATAAACCCTTCAAAAGGTATTAACAAAATGTTTACCA 
                   
               
               
                   
                 AACCTATTGCTTTATTTTAAAAACATAATTTGTGTTTTCTATTTGTAAGATC 
                   
               
               
                   
                 TGACATTTCGAGGCAATAAAAACTTCTCAGAAAGTAAAAAAAAAAAAAA 
                   
               
               
                   
                 A 
               
               
                   
               
            
           
         
       
     
     Preferably, the expression of each of the 13-gene set is determined to provide the VEGF-signature score. An average expression value across the genes can be determined, i.e., by determining a log 2  expression ratio. The sample may be assigned or classified into a high expression group, an intermediate expression group, and a low expression group based on the 13-gene average log 2  expression ratio using cutoff values (i.e., −0.63/0.08) identified using X-tile and relapse-free survival, as described in Camp et al.,  Clin. Cancer Res.  10(21):7252-7259. The methods for determining the VEGF-signature score from a biological sample are as described in Hu et al.,  BMC Medicine  7:9 (2009) and supplemental online material. 
     The methods of the present invention may further include measuring the expression of DNA repair genes, such as RAD17, RAD50, and tumor suppressor RB1. Select nucleic acid sequences for these additional genes are shown in Table 8 below. 
     
       
         
           
               
               
               
             
               
                 TABLE 8 
               
               
                   
               
               
                 GENE NAME 
                   
                   
               
               
                 GENBANK 
                   
                 SEQ 
               
               
                 ACCESSION 
                   
                 ID 
               
               
                 NUMBER 
                 SEQUENCE 
                 NO: 
               
               
                   
               
             
            
               
                 RAD17 
                 ACCTGTATACCTTTTGAAACGTCACAGTCTCTAATCGTGAACGATTT 
                 211 
               
               
                 AF076838.1 
                 GGGGCGGAGGGCTGAACAATGTGTTTTCTAGTGTGTCGAGGTGTTTA 
                   
               
               
                   
                 TAGGCTATGTGTGCCTCCAAACTGTAAAGTAGTCCAGTATACTTTCC 
                   
               
               
                   
                 AATGTATAAGTTTGTAGACCTTAAACTTTTCTTCTGGCTAACTTAAAA 
                   
               
               
                   
                 TCGTTGAATTCACTAGTTTGCATAAACATTTAAGAATTTGAAAACAC 
                   
               
               
                   
                 GGTTGAAAAACAGTGTTACCAAGAAATTTTGTAATAACATGTTCAAA 
                   
               
               
                   
                 TGAAGACAAAAATTTTACAGTTTAAGACTTAAATTCTTCGTCCACAG 
                   
               
               
                   
                 CAAGTGAATTCATGGTATTTTACTTTTTTGGGAAATACTGGAAATGA 
                   
               
               
                   
                 AGACCTGCAACTGTAATTTGAAATAAGGAAAACTTTAATTTTCAGTA 
                   
               
               
                   
                 TAAAAATTGCTCAAATAGAATTGCCTGATTTTAATGACAAAAGTATA 
                   
               
               
                   
                 TGGGAGTCCACATTTATGTAAGAAATGAAACTATAAAATGTATAAAT 
                   
               
               
                   
                 AATTTGCAAATCAGAATTGCTGTCGAAAGTTTTACTATAATGAAAGA 
                   
               
               
                   
                 TATTTTCATACTCTCAAAAATATAGAGGAAAGGGGCCAAGATTATAG 
                   
               
               
                   
                 TACCAGTCACAATCTTTTGATGAGGACGAAATGAATCAGGTAACAG 
                   
               
               
                   
                 ACTGGGTTGACCCATCATTTGATGATTTTCTAGAGTGTAGTGGCGTCT 
                   
               
               
                   
                 CTACTATTACTGCCACATCATTAGGTGTGAATAACTCAAGTCATAGA 
                   
               
               
                   
                 AGAAAAAATGGGCCTTCTACATTAGAAAGCAGCAGATTTCCAGCGA 
                   
               
               
                   
                 GAAAAAGAGGAAATCTATCTTCCTTAGAACAGATTTATGGTTTAGAA 
                   
               
               
                   
                 AATTCAAAAGAATATCTGTCTGAAAATGAACCATGGGTGGATAAAT 
                   
               
               
                   
                 ATAAACCAGAAACTCAGCATGAACTTGCTGTGCATAAAAAGAAAAT 
                   
               
               
                   
                 TGAAGAAGTCGAAACCTGGTTAAAAGCTCAAGTTTTAGAAAGGCAA 
                   
               
               
                   
                 CCAAAACAGGGTGGATCTATTTTATTAATAACAGGTCCTCCTGGATG 
                   
               
               
                   
                 TGGAAAGACAACGACCTTAAAAATACTATCAAAGGAGCATGGTATT 
                   
               
               
                   
                 CAAGTACAAGAGTGGATTAATCCAGTTTTACCAGACTTCCAAAAAG 
                   
               
               
                   
                 ATGATTTCAAGGGGATGTTTAATACTGAATCAAGCTTCCATATGTTT 
                   
               
               
                   
                 CCCTATCAGTCTCAGATAGCAGTTTTCAAAGAGTTTCTACTAAGAGC 
                   
               
               
                   
                 GACAAAGTATAACAAGTTACAAATGCTTGGAGATGATCTGAGAACT 
                   
               
               
                   
                 GATAAGAAGATAATTCTGGTTGAAGATTTACCTAACCAGTTTTATCG 
                   
               
               
                   
                 GGATTCTCATACTTTACATGAAGTTCTAAGGAAGTATGTGAGGATTG 
                   
               
               
                   
                 GTCGATGTCCTCTTATATTTATAATCTCGGACAGTCTCAGTGGAGAT 
                   
               
               
                   
                 AATAATCAAAGGTTATTGTTTCCCAAAGAAATTCAGGAAGAGTGTTC 
                   
               
               
                   
                 TATCTCAAATATTAGTTTCAACCCTGTGGCACCAACAATTATGATGA 
                   
               
               
                   
                 AATTTCTTAATCGAATAGTGACTATAGAAGCTAACAAGAATGGAGG 
                   
               
               
                   
                 AAAAATTACTGTCCCTGACAAAACTTCTCTAGAGTTGCTCTGTCAGG 
                   
               
               
                   
                 GATGTTCTGGTGATATCAGAAGTGCAATAAACAGCCTCCAGTTTTCT 
                   
               
               
                   
                 TCTTCAAAAGGAGAAAACAACTTACGGCCAAGGAAAAAAGGAATGT 
                   
               
               
                   
                 CTTTAAAATCAGATGCTGTGCTGTCAAAATCAAAACGAAGAAAAAA 
                   
               
               
                   
                 ACCTGATAGGGTTTTTGAAAATCAAGAGGTCCAAGCTATTGGTGGCA 
                   
               
               
                   
                 AAGATGTTTCTCTGTTTCTCTTCAGAGCTTTGGGGAAAATTCTATATT 
                   
               
               
                   
                 GTAAAAGAGCATCTTTAACAGAATTAGACTCACCTCGGTTGCCCTCT 
                   
               
               
                   
                 CATTTATCAGAATATGAACGGGATACATTACTTGTTGAACCTGAGGA 
                   
               
               
                   
                 GGTAGTAGAAATGTCACACATGCCTGGAGACTTATTTAATTTATATC 
                   
               
               
                   
                 TTCACCAAAACTACATAGATTTCTTCATGGAAATTGATGATATTGTG 
                   
               
               
                   
                 AGAGCCAGTGAATTTCTGAGTTTTGCAGATATCCTCAGTGGTGACTG 
                   
               
               
                   
                 GAATACACGCTCTTTACTCAGGGAATATAGCACATCTATAGCTACGA 
                   
               
               
                   
                 GAGGTGTGATGCATTCCAACAAAGCCCGAGGATATGCTCATTGCCA 
                   
               
               
                   
                 AGGAGGAGGATCAAGTTTTCGACCCTTGCACAAACCTCAGTGGTTTC 
                   
               
               
                   
                 TAATAAATAAAAAGTATCGGGAAAATTGCCTGGCAGCAAAAGCACT 
                   
               
               
                   
                 TTTTCCTGACTTCTGCCTACCAGCTTTATGCCTCCAAACTCAGCTATT 
                   
               
               
                   
                 GCCATACCTTGCTCTACTAACCATTCCAATGAGAAATCAAGCTCAGA 
                   
               
               
                   
                 TTTCTTTTATCCAAGATATTGGAAGGCTCCCTCTGAAGCGACACTTTG 
                   
               
               
                   
                 GAAGATTGAAAATGGAAGCCCTGACTGACAGGGAACATGGAATGAT 
                   
               
               
                   
                 AGACCCTGACAGCGGAGATGAAGCCCAGCTTAATGGAGGACATTCT 
                   
               
               
                   
                 GCAGAGGAATCTCTGGGTGAACCCACTCAAGCCACTGTGCCGGAAA 
                   
               
               
                   
                 CCTGGTCTCTTCCTTTGAGTCAGAATAGTGCCAGTGAACTGCCTGCT 
                   
               
               
                   
                 AGCCAGCCCCAGCCCTTTTCAGCCCAAGGAGACATGGAAGAAAACA 
                   
               
               
                   
                 TAATAATAGAAGACTACGAGAGTGATGGGACATAGAAGCCAGCCTG 
                   
               
               
                   
                 CTAATCAGATTGCTACTTCACAGCTTCATTTTTGTTTCATTCAGTGGT 
                   
               
               
                   
                 ACTTCAGCAGAGTTAATATGCTTTTCTGATGAATTACACAACAGTTT 
                   
               
               
                   
                 GTTAATTCTTCATTCTTGTAGTATTTCATCACAAGAAACCTACTCTTC 
                   
               
               
                   
                 TGTCATCTTGAAGTAAATAGAAGATCAAGCCTTCAAATCTCTTAATT 
                   
               
               
                   
                 TTTTCGGTATTTATTAAATCTGTGAGTGGTTTAAGGAGCGGTCAGTGT 
                   
               
               
                   
                 GTATAAAGTGTGTTTGAACATTATGCCAAATATCAAGATGTGAAGGA 
                   
               
               
                   
                 CTAATTCAGGATGCAAAAACGTTATTGGGGGGTTGTAAATATCAACT 
                   
               
               
                   
                 ATTCAACAGTTTAGGATGCAATTACGAGTGTAAACTGTGTGCCTTAT 
                   
               
               
                   
                 TTACACTTTATTGTCTCCCGCTTCTCAGATAGTTTTGATGTGTTGTAC 
                   
               
               
                   
                 AGTGGAATATCTTAGATACTTTTTGGAAAGTATTTACATAAGTTATA 
                   
               
               
                   
                 TCACAATTAAAATGTTGAATTTAA 
                   
               
               
                   
               
               
                 RAD50 
                 TTTCCCGGCGTGCCCCAGGAGAGCGGCGTGGACGCGTGCGGGCCTA 
                 212 
               
               
                 NM_005732.3 
                 GAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGT 
                   
               
               
                   
                 GCGCGGTTGCGGGGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCG 
                   
               
               
                   
                 GGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGA 
                   
               
               
                   
                 AAGCAGCTGGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTC 
                   
               
               
                   
                 CCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCC 
                   
               
               
                   
                 CCGCCCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGT 
                   
               
               
                   
                 GCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGACTCCAGGTCC 
                   
               
               
                   
                 CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGA 
                   
               
               
                   
                 TGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGATAA 
                   
               
               
                   
                 GCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAA 
                   
               
               
                   
                 TGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATATATTTGTA 
                   
               
               
                   
                 CTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGAT 
                   
               
               
                   
                 CCCAAGGTTGCTCAAGAAACAGATGTGAGAGCCCAGATTCGTCTGC 
                   
               
               
                   
                 AATTTCGTGATGTCAATGGAGAACTTATAGCTGTGCAAAGATCTATG 
                   
               
               
                   
                 GTGTGTACTCAGAAAAGCAAAAAGACAGAATTTAAAACTCTGGAAG 
                   
               
               
                   
                 GAGTCATTACTAGAACAAAGCATGGTGAAAAGGTCAGTCTGAGCTC 
                   
               
               
                   
                 TAAGTGTGCAGAAATTGACCGAGAAATGATCAGTTCTCTTGGGGTTT 
                   
               
               
                   
                 CCAAGGCTGTGCTAAATAATGTCATTTTCTGTCATCAAGAAGATTCT 
                   
               
               
                   
                 AATTGGCCTTTAAGTGAAGGAAAGGCTTTGAAGCAAAAGTTTGATG 
                   
               
               
                   
                 AGATTTTTTCAGCAACAAGATACATTAAAGCCTTAGAAACACTTCGG 
                   
               
               
                   
                 CAGGTACGTCAGACACAAGGTCAGAAAGTAAAAGAATATCAAATGG 
                   
               
               
                   
                 AACTAAAATATCTGAAGCAATATAAGGAAAAAGCTTGTGAGATTCG 
                   
               
               
                   
                 TGATCAGATTACAAGTAAGGAAGCCCAGTTAACATCTTCAAAGGAA 
                   
               
               
                   
                 ATTGTCAAATCCTATGAGAATGAACTTGATCCATTGAAGAATCGTCT 
                   
               
               
                   
                 AAAAGAAATTGAACATAATCTCTCTAAAATAATGAAACTTGACAAT 
                   
               
               
                   
                 GAAATTAAAGCCTTGGATAGCCGAAAGAAGCAAATGGAGAAAGATA 
                   
               
               
                   
                 ATAGTGAACTGGAAGAGAAAATGGAAAAGGTTTTTCAAGGGACTGA 
                   
               
               
                   
                 TGAGCAACTAAATGACTTATATCACAATCACCAGAGAACAGTAAGG 
                   
               
               
                   
                 GAGAAAGAAAGGAAATTGGTAGACTGTCATCGTGAACTGGAAAAAC 
                   
               
               
                   
                 TAAATAAAGAATCTAGGCTTCTCAATCAGGAAAAATCAGAACTGCTT 
                   
               
               
                   
                 GTTGAACAGGGTCGTCTACAGCTGCAAGCAGATCGCCATCAAGAAC 
                   
               
               
                   
                 ATATCCGAGCTAGAGATTCATTAATTCAGTCTTTGGCAACACAGCTA 
                   
               
               
                   
                 GAATTGGATGGCTTTGAGCGTGGACCATTCAGTGAAAGACAGATTA 
                   
               
               
                   
                 AAAATTTTCACAAACTTGTGAGAGAGAGACAAGAAGGGGAAGCAAA 
                   
               
               
                   
                 AACTGCCAACCAACTGATGAATGACTTTGCAGAAAAAGAGACTCTG 
                   
               
               
                   
                 AAACAAAAACAGATAGATGAGATAAGAGATAAGAAAACTGGACTG 
                   
               
               
                   
                 GGAAGAATAATTGAGTTAAAATCAGAAATCCTAAGTAAGAAGCAGA 
                   
               
               
                   
                 ATGAGCTGAAAAATGTGAAGTATGAATTACAGCAGTTGGAAGGATC 
                   
               
               
                   
                 TTCAGACAGGATTCTTGAACTGGACCAGGAGCTCATAAAAGCTGAA 
                   
               
               
                   
                 CGTGAGTTAAGCAAGGCTGAGAAAAACAGCAATGTAGAAACCTTAA 
                   
               
               
                   
                 AAATGGAAGTAATAAGTCTCCAAAATGAAAAAGCAGACTTAGACAG 
                   
               
               
                   
                 GACCCTGCGTAAACTTGACCAGGAGATGGAGCAGTTAAACCATCAT 
                   
               
               
                   
                 ACAACAACACGTACCCAAATGGAGATGCTGACCAAAGACAAAGCTG 
                   
               
               
                   
                 ACAAAGATGAACAAATCAGAAAAATAAAATCTAGGCACAGTGATGA 
                   
               
               
                   
                 ATTAACCTCACTGTTGGGATATTTTCCCAACAAAAAACAGCTTGAAG 
                   
               
               
                   
                 ACTGGCTACATAGTAAATCAAAAGAAATTAATCAGACCAGGGACAG 
                   
               
               
                   
                 ACTTGCCAAATTGAACAAGGAACTAGCTTCATCTGAGCAGAATAAA 
                   
               
               
                   
                 AATCATATAAATAATGAACTAAAAAGAAAGGAAGAGCAGTTGTCCA 
                   
               
               
                   
                 GTTACGAAGACAAGCTGTTTGATGTTTGTGGTAGCCAGGATTTTGAA 
                   
               
               
                   
                 AGTGATTTAGACAGGCTTAAAGAGGAAATTGAAAAATCATCAAAAC 
                   
               
               
                   
                 AGCGAGCCATGCTGGCTGGAGCCACAGCAGTTTACTCCCAGTTCATT 
                   
               
               
                   
                 ACTCAGCTAACAGACGAAAACCAGTCATGTTGCCCCGTTTGTCAGAG 
                   
               
               
                   
                 AGTTTTTCAGACAGAGGCTGAGTTACAAGAAGTCATCAGTGATTTGC 
                   
               
               
                   
                 AGTCTAAACTGCGACTTGCTCCAGATAAACTCAAGTCAACAGAATCA 
                   
               
               
                   
                 GAGCTAAAAAAAAAGGAAAAGCGGCGTGATGAAATGCTGGGACTTG 
                   
               
               
                   
                 TGCCCATGAGGCAAAGCATAATTGATTTGAAGGAGAAGGAAATACC 
                   
               
               
                   
                 AGAATTAAGAAACAAACTGCAGAATGTCAATAGAGACATACAGCGC 
                   
               
               
                   
                 CTAAAGAACGACATAGAAGAACAAGAAACACTCTTGGGTACAATAA 
                   
               
               
                   
                 TGCCTGAAGAAGAAAGTGCCAAAGTATGCCTGACAGATGTTACAAT 
                   
               
               
                   
                 TATGGAGAGGTTCCAGATGGAACTTAAAGATGTTGAAAGAAAAATT 
                   
               
               
                   
                 GCACAACAAGCAGCTAAGCTACAAGGAATAGACTTAGATCGAACTG 
                   
               
               
                   
                 TCCAACAAGTCAACCAGGAGAAACAAGAGAAACAGCACAAGTTAG 
                   
               
               
                   
                 ACACAGTTTCTAGTAAGATTGAATTGAATCGTAAGCTTATACAGGAC 
                   
               
               
                   
                 CAGCAGGAACAGATTCAACATCTAAAAAGTACAACAAATGAGCTAA 
                   
               
               
                   
                 AATCTGAGAAACTTCAGATATCCACTAATTTGCAACGTCGTCAGCAA 
                   
               
               
                   
                 CTGGAGGAGCAGACTGTGGAATTATCCACTGAAGTTCAGTCTTTGTA 
                   
               
               
                   
                 CAGAGAGATAAAGGATGCTAAAGAGCAGGTAAGCCCTTTGGAAACA 
                   
               
               
                   
                 ACATTGGAAAAGTTCCAGCAAGAAAAAGAAGAATTAATCAACAAAA 
                   
               
               
                   
                 AAAATACAAGCAACAAAATAGCACAGGATAAACTGAATGATATTAA 
                   
               
               
                   
                 AGAGAAGGTTAAAAATATTCATGGCTATATGAAAGACATTGAGAAT 
                   
               
               
                   
                 TATATTCAAGATGGGAAAGACGACTATAAGAAGCAAAAAGAAACTG 
                   
               
               
                   
                 AACTTAATAAAGTAATAGCTCAACTAAGTGAATGCGAGAAACACAA 
                   
               
               
                   
                 AGAAAAGATAAATGAAGATATGAGACTCATGAGACAAGATATTGAT 
                   
               
               
                   
                 ACACAGAAGATACAAGAAAGGTGGCTACAAGATAACCTTACTTTAA 
                   
               
               
                   
                 GAAAAAGAAATGAGGAACTAAAAGAAGTTGAAGAAGAAAGAAAAC 
                   
               
               
                   
                 AACATTTGAAGGAAATGGGTCAAATGCAGGTTTTGCAAATGAAAAG 
                   
               
               
                   
                 TGAACATCAGAAGTTGGAAGAGAACATAGACAATATAAAAAGAAAT 
                   
               
               
                   
                 CATAATTTGGCATTAGGGCGACAGAAAGGTTATGAAGAAGAAATTA 
                   
               
               
                   
                 TTCATTTTAAGAAAGAACTTCGAGAACCACAATTTCGGGATGCTGAG 
                   
               
               
                   
                 GAAAAGTATAGAGAAATGATGATTGTTATGAGGACAACAGAACTTG 
                   
               
               
                   
                 TGAACAAGGATCTGGATATTTATTATAAGACTCTTGACCAAGCAATA 
                   
               
               
                   
                 ATGAAATTTCACAGTATGAAAATGGAAGAAATCAATAAAATTATAC 
                   
               
               
                   
                 GTGACCTGTGGCGAAGTACCTATCGTGGACAAGATATTGAATACATA 
                   
               
               
                   
                 GAAATACGGTCTGATGCCGATGAAAATGTATCAGCTTCTGATAAAAG 
                   
               
               
                   
                 GCGGAATTATAACTACCGAGTGGTGATGCTGAAGGGAGACACAGCC 
                   
               
               
                   
                 TTGGATATGCGAGGACGATGCAGTGCTGGACAAAAGGTATTAGCCT 
                   
               
               
                   
                 CACTCATCATTCGCCTGGCCCTGGCTGAAACGTTCTGCCTCAACTGT 
                   
               
               
                   
                 GGCATCATTGCCTTGGATGAGCCAACAACAAATCTTGACCGAGAAA 
                   
               
               
                   
                 ACATTGAATCTCTTGCACATGCTCTGGTTGAGATAATAAAAAGTCGC 
                   
               
               
                   
                 TCACAGCAGCGTAACTTCCAGCTTCTGGTAATCACTCATGATGAAGA 
                   
               
               
                   
                 TTTTGTGGAGCTTTTAGGACGTTCTGAATATGTGGAGAAATTCTACA 
                   
               
               
                   
                 GGATTAAAAAGAACATCGATCAGTGCTCAGAGATTGTGAAATGCAG 
                   
               
               
                   
                 TGTTAGCTCCCTGGGATTCAATGTTCATTAAAAATATCCAAGATTTA 
                   
               
               
                   
                 AATGCCATAGAAATGTAGGTCCTCAGAAAGTGTATAATAAGAAACT 
                   
               
               
                   
                 TATTTCTCATATCAACTTAGTCAATAAGAAAATATATTCTTTCAAAG 
                   
               
               
                   
                 GAACATTGTGTCTAGGATTTTGGATGTTGAGAGGTTCTAAAATCATG 
                   
               
               
                   
                 AAACTTGTTTCACTGAAAATTGGACAGATTGCCTGTTTCTGATTTGCT 
                   
               
               
                   
                 GCTCTTCATCCCATTCCAGGCAGCCTCTGTCAGGCCTTCAGGGTTCA 
                   
               
               
                   
                 GCAGTACAGCCGAGACTCGACTCTGTGCCTCCCTCCCCAGTGCAAAT 
                   
               
               
                   
                 GCATGCTTCTTCTCAAAGCACTGTTGAGAAGGAGATAATTACTGCCT 
                   
               
               
                   
                 TGAAAATTTATGGTTTTGGTATTTTTTTAAATCATAGTTAAATGTTAC 
                   
               
               
                   
                 CTCTGAATTTACTTCCTTGCATGTGGTTTGAAAAACTGAGTATTAATA 
                   
               
               
                   
                 TCTGAGGATGACCAGAAATGGTGAGATGTATGTTTGGCTCTGCTTTT 
                   
               
               
                   
                 AACTTTATAAATCCAGTGACCTCTCTCTCTGGGACTTGGTTTCCCCAA 
                   
               
               
                   
                 CTAAAATTTGAAGTAGTTGAATGGGGTCTCAAAGTTTGACAGGAACC 
                   
               
               
                   
                 TTAAGTAATCATCTAAGTCAGTACCCACCACCTTCTTCTCCTACATAT 
                   
               
               
                   
                 CCCTTCCAGATGGTCATCCAGACTCAGAGCTCTCTCTACAGAGAGGA 
                   
               
               
                   
                 AATTCTCCACTGTGCACACCCACCTTTGGAAAGCTCTGACCACTTGA 
                   
               
               
                   
                 GGCCTGATCTGCCCATCGTGAAGAAGCCTGTAACACTCCTCTGCGTC 
                   
               
               
                   
                 TATCCTGTGTAGCATACTGGCTTCACCATCAATCCTGATTCCTCTCTA 
                   
               
               
                   
                 AGTGGGCATTGCCATGTGGAAGGCAAGCCAGGCTCACTCACAGAGT 
                   
               
               
                   
                 CAAGGCCTGCTCCCTGTAGGGTCCAACCAGACCTGGAAGAACAGGC 
                   
               
               
                   
                 CTCTCCATTTGCTCTTCAGATGCCACTTCTAAGAAAAGCCTAATCAC 
                   
               
               
                   
                 AGTTTTTCCTGGAATTGCCAGCTGACATCTTGAATCCTTCCATTCCAC 
                   
               
               
                   
                 ACAGAATGCAACCAAGTCACACGCTTTTGAATTATGCTTTGTAGAGT 
                   
               
               
                   
                 TTTGTCATTCAGAGTCAGCCAGGACCATACCGGGTCTTGATTCAGTC 
                   
               
               
                   
                 ACATGGCATGGTTTTGTGCCATCTGTAGCTATAATGAGCATGTTTGC 
                   
               
               
                   
                 CTAGACAGCTTTTCTCAACTGGGTCCAGAAGAGAATTAAGCCCTAAG 
                   
               
               
                   
                 GTCCTAAGGCATCTATCTGTGCTAGGTTAAATGGTTGGCCCCCAAAG 
                   
               
               
                   
                 ATAGACAGGTCCTGATTTCTAGAACCCGTGACTGTTACTTTATACAG 
                   
               
               
                   
                 CAAAGGAAACTTTGCAGATGTGATTAAAGCTAAGGACCTTAAGACA 
                   
               
               
                   
                 GAGTATCCTGGGGGTGGTGGTGGGGTGGGGGGGGGTCCTAAATGTA 
                   
               
               
                   
                 ATCACGAGTAAGATTAAGAGCAAATCAATTCTAGTCATATATTAAAC 
                   
               
               
                   
                 ATCCACAATAACCAAGATATTTTTATCCCAAGAATGCAAGATTTCAG 
                   
               
               
                   
                 AAAATGAAAAATCTGTTGATAAATCCATCACTATAATAAAACCGAA 
                   
               
               
                   
                 GGTGAAAAAAATTCTGAAAAAATTCTAGCAGCTATATTTGATAAAAT 
                   
               
               
                   
                 TCAACATCTCCTAGCTTTAGCAAACTCACAGTTTTGCAAATAATATTT 
                   
               
               
                   
                 TCTTAATGTTATCTGTTGCTAAATCAAAATTAAACAGTCATCTTAACT 
                   
               
               
                   
                 GCAAAATAAAACATTTCTCAGTAAATATTAAAGCCAGTTACCTTCTA 
                   
               
               
                   
                 TCAACATGTTAATGAAAGTGCTAGTTGTTGCAGCAAAGAATAACAA 
                   
               
               
                   
                 AGGCAATACACGATCAATATAGGCAGTGAAACAAAAGTATCATTTG 
                   
               
               
                   
                 CAAGTTAAAACAGACTTCCCAATTTTAAATCTGGTTTCCCCCTGAAT 
                   
               
               
                   
                 ATGTGGCATCCTTGGCAGCACTTCTGAGAGTGGCTGCTTTCATTCCA 
                   
               
               
                   
                 AGAAGCCCATGGGTTTGGAGGTGGGATAGGTGCCTTTCTGGCTTCTC 
                   
               
               
                   
                 ATTGCTGCTTCTAGATCAGTCTCCAAATATCCCCCTTCCCCACATTGG 
                   
               
               
                   
                 AATGAATAGCCATCACAGCATGGATGGAGGTTAGAATGAGCCAGAC 
                   
               
               
                   
                 TGCCTGGGCTCAAATCCTAGCACACCACTCACTAGCTGGGGACCTTG 
                   
               
               
                   
                 AGCAAGTTATTTGTCCTGTTTTCTGTTTCCTTATATGTAAAAGTGGGT 
                   
               
               
                   
                 AAAATGGTACATATTTTGTAGGGTTGTTATGAAGATTGAATGACATT 
                   
               
               
                   
                 ATTTACAAACTGCTTAGAACTGCTTGCCACCTACTAAATACTGTGTA 
                   
               
               
                   
                 AGTGTTCAAGAAAAAGCTGTCTTCATTTCA 
                   
               
               
                   
               
               
                 RB1 
                 GCTCAGTTGCCGGGCGGGGGAGGGCGCGTCCGGTTTTTCTCAGGGG 
                 213 
               
               
                 NM_000321.2 
                 ACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGT 
                   
               
               
                   
                 GCCCCGACGTGCGCGCGCGTCGTCCTCCCCGGCGCTCCTCCACAGCT 
                   
               
               
                   
                 CGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCC 
                   
               
               
                   
                 GAAAAACGGCCGCCACCGCCGCCGCTGCCGCCGCGGAACCCCCGGC 
                   
               
               
                   
                 ACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGC 
                   
               
               
                   
                 GGCCCGGAGGACCTGCCTCTCGTCAGGCTTGAGTTTGAAGAAACAG 
                   
               
               
                   
                 AAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGAT 
                   
               
               
                   
                 CATGTCAGAGAGAGAGCTTGGTTAACTTGGGAGAAAGTTTCATCTGT 
                   
               
               
                   
                 GGATGGAGTATTGGGAGGTTATATTCAAAAGAAAAAGGAACTGTGG 
                   
               
               
                   
                 GGAATCTGTATCTTTATTGCAGCAGTTGACCTAGATGAGATGTCGTT 
                   
               
               
                   
                 CACTTTTACTGAGCTACAGAAAAACATAGAAATCAGTGTCCATAAAT 
                   
               
               
                   
                 TCTTTAACTTACTAAAAGAAATTGATACCAGTACCAAAGTTGATAAT 
                   
               
               
                   
                 GCTATGTCAAGACTGTTGAAGAAGTATGATGTATTGTTTGCACTCTT 
                   
               
               
                   
                 CAGCAAATTGGAAAGGACATGTGAACTTATATATTTGACACAACCC 
                   
               
               
                   
                 AGCAGTTCGATATCTACTGAAATAAATTCTGCATTGGTGCTAAAAGT 
                   
               
               
                   
                 TTCTTGGATCACATTTTTATTAGCTAAAGGGGAAGTATTACAAATGG 
                   
               
               
                   
                 AAGATGATCTGGTGATTTCATTTCAGTTAATGCTATGTGTCCTTGACT 
                   
               
               
                   
                 ATTTTATTAAACTCTCACCTCCCATGTTGCTCAAAGAACCATATAAA 
                   
               
               
                   
                 ACAGCTGTTATACCCATTAATGGTTCACCTCGAACACCCAGGCGAGG 
                   
               
               
                   
                 TCAGAACAGGAGTGCACGGATAGCAAAACAACTAGAAAATGATACA 
                   
               
               
                   
                 AGAATTATTGAAGTTCTCTGTAAAGAACATGAATGTAATATAGATGA 
                   
               
               
                   
                 GGTGAAAAATGTTTATTTCAAAAATTTTATACCTTTTATGAATTCTCT 
                   
               
               
                   
                 TGGACTTGTAACATCTAATGGACTTCCAGAGGTTGAAAATCTTTCTA 
                   
               
               
                   
                 AACGATACGAAGAAATTTATCTTAAAAATAAAGATCTAGATGCAAG 
                   
               
               
                   
                 ATTATTTTTGGATCATGATAAAACTCTTCAGACTGATTCTATAGACA 
                   
               
               
                   
                 GTTTTGAAACACAGAGAACACCACGAAAAAGTAACCTTGATGAAGA 
                   
               
               
                   
                 GGTGAATGTAATTCCTCCACACACTCCAGTTAGGACTGTTATGAACA 
                   
               
               
                   
                 CTATCCAACAATTAATGATGATTTTAAATTCAGCAAGTGATCAACCT 
                   
               
               
                   
                 TCAGAAAATCTGATTTCCTATTTTAACAACTGCACAGTGAATCCAAA 
                   
               
               
                   
                 AGAAAGTATACTGAAAAGAGTGAAGGATATAGGATACATCTTTAAA 
                   
               
               
                   
                 GAGAAATTTGCTAAAGCTGTGGGACAGGGTTGTGTCGAAATTGGATC 
                   
               
               
                   
                 ACAGCGATACAAACTTGGAGTTCGCTTGTATTACCGAGTAATGGAAT 
                   
               
               
                   
                 CCATGCTTAAATCAGAAGAAGAACGATTATCCATTCAAAATTTTAGC 
                   
               
               
                   
                 AAACTTCTGAATGACAACATTTTTCATATGTCTTTATTGGCGTGCGCT 
                   
               
               
                   
                 CTTGAGGTTGTAATGGCCACATATAGCAGAAGTACATCTCAGAATCT 
                   
               
               
                   
                 TGATTCTGGAACAGATTTGTCTTTCCCATGGATTCTGAATGTGCTTAA 
                   
               
               
                   
                 TTTAAAAGCCTTTGATTTTTACAAAGTGATCGAAAGTTTTATCAAAG 
                   
               
               
                   
                 CAGAAGGCAACTTGACAAGAGAAATGATAAAACATTTAGAACGATG 
                   
               
               
                   
                 TGAACATCGAATCATGGAATCCCTTGCATGGCTCTCAGATTCACCTT 
                   
               
               
                   
                 TATTTGATCTTATTAAACAATCAAAGGACCGAGAAGGACCAACTGAT 
                   
               
               
                   
                 CACCTTGAATCTGCTTGTCCTCTTAATCTTCCTCTCCAGAATAATCAC 
                   
               
               
                   
                 ACTGCAGCAGATATGTATCTTTCTCCTGTAAGATCTCCAAAGAAAAA 
                   
               
               
                   
                 AGGTTCAACTACGCGTGTAAATTCTACTGCAAATGCAGAGACACAA 
                   
               
               
                   
                 GCAACCTCAGCCTTCCAGACCCAGAAGCCATTGAAATCTACCTCTCT 
                   
               
               
                   
                 TTCACTGTTTTATAAAAAAGTGTATCGGCTAGCCTATCTCCGGCTAA 
                   
               
               
                   
                 ATACACTTTGTGAACGCCTTCTGTCTGAGCACCCAGAATTAGAACAT 
                   
               
               
                   
                 ATCATCTGGACCCTTTTCCAGCACACCCTGCAGAATGAGTATGAACT 
                   
               
               
                   
                 CATGAGAGACAGGCATTTGGACCAAATTATGATGTGTTCCATGTATG 
                   
               
               
                   
                 GCATATGCAAAGTGAAGAATATAGACCTTAAATTCAAAATCATTGTA 
                   
               
               
                   
                 ACAGCATACAAGGATCTTCCTCATGCTGTTCAGGAGACATTCAAACG 
                   
               
               
                   
                 TGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATA 
                   
               
               
                   
                 ACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCT 
                   
               
               
                   
                 TCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAG 
                   
               
               
                   
                 CCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACA 
                   
               
               
                   
                 TCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTG 
                   
               
               
                   
                 CCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAA 
                   
               
               
                   
                 TTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAG 
                   
               
               
                   
                 ATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAA 
                   
               
               
                   
                 GCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGA 
                   
               
               
                   
                 TCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAAT 
                   
               
               
                   
                 TTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCA 
                   
               
               
                   
                 AAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGA 
                   
               
               
                   
                 GAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGA 
                   
               
               
                   
                 TTCATTGTCTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTT 
                   
               
               
                   
                 TATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTG 
                   
               
               
                   
                 CAGATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTC 
                   
               
               
                   
                 ATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTA 
                   
               
               
                   
                 AAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGC 
                   
               
               
                   
                 TTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCA 
                   
               
               
                   
                 GGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTT 
                   
               
               
                   
                 GCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAA 
                   
               
               
                   
                 CACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTG 
                   
               
               
                   
                 ACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGAT 
                   
               
               
                   
                 ATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTT 
                   
               
               
                   
                 ATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTT 
                   
               
               
                   
                 TGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATA 
                   
               
               
                   
                 CTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGAAC 
                   
               
               
                   
                 TTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTAT 
                   
               
               
                   
                 TGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAATTTATAAA 
                   
               
               
                   
                 GTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAG 
                   
               
               
                   
                 GTATAGAGGACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGT 
                   
               
               
                   
                 TTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAA 
                   
               
               
                   
                 CAGACTGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGT 
                   
               
               
                   
                 CTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTT 
                   
               
               
                   
                 GTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGG 
                   
               
               
                   
                 CAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACT 
                   
               
               
                   
                 GGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATC 
                   
               
               
                   
                 AAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCA 
                   
               
               
                   
                 AAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTC 
                   
               
               
                   
                 CCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAAC 
                   
               
               
                   
                 TTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCT 
                   
               
               
                   
                 TCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTT 
                   
               
               
                   
                 AAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTC 
                   
               
               
                   
                 ATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATGA 
                   
               
               
                   
                 CACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCA 
                   
               
               
                   
                 TACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCTGGGTCTT 
                   
               
               
                   
                 TTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTT 
                   
               
               
                   
                 CAGAGATCGTGTATTGAGATTTCTTAAATAATGCTTCAGATATTATT 
                   
               
               
                   
                 GCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCT 
                   
               
               
                   
                 ATGTTACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATT 
                   
               
               
                   
                 AGTTGTTAAGAGTCTTAA 
               
               
                   
               
            
           
         
       
     
     Breast Cancer 
     Subjects with breast cancer tumors that fit in the Luminal A or Basal-like subtype, classified by gene expression analysis, were surprisingly found to have a significantly decreased rate of local recurrence and significantly increased rate of breast cancer specific survival when treated with a post-mastectomy breast cancer treatment that included radiation. 
     Classifying breast cancer tumors by intrinsic subtype and treating patients with radiation only when this treatment provides increased therapeutic efficacy to offset the added cost and side effects can improve the clinical outcome and quality of life of thousands of patients. 
     For the purposes of the present disclosure, “breast cancer” includes, for example, those conditions classified by biopsy or histology as malignant pathology. The clinical delineation of breast cancer diagnoses is well known in the medical arts. One of skill in the art will appreciate that breast cancer refers to any malignancy of the breast tissue, including, for example, carcinomas and sarcomas. Particular embodiments of breast cancer include ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS), or mucinous carcinoma. Breast cancer also refers to infiltrating ductal carcinoma (IDC), lobular neoplasia or infiltrating lobular carcinoma (ILC). In most embodiments of the disclosure, the subject of interest is a human patient suspected of or actually diagnosed with breast cancer. 
     Breast cancer includes all forms of cancer of the breast. Breast cancer can include primary epithelial breast cancers. Breast cancer can include cancers in which the breast is involved by other tumors such as lymphoma, sarcoma or melanoma. Breast cancer can include carcinoma of the breast, ductal carcinoma of the breast, lobular carcinoma of the breast, undifferentiated carcinoma of the breast, cystosarcoma phyllodes of the breast, angiosarcoma of the breast, and primary lymphoma of the breast. Breast cancer can include Stage I, II, IIIA, IIIB, IIIC and IV breast cancer. Ductal carcinoma of the breast can include invasive carcinoma, invasive carcinoma in situ with predominant intraductal component, inflammatory breast cancer, and a ductal carcinoma of the breast with a histologic type selected from the group consisting of comedo, mucinous (colloid), medullary, medullary with lymphcytic infiltrate, papillary, scirrhous, and tubular. Lobular carcinoma of the breast can include invasive lobular carcinoma with predominant in situ component, invasive lobular carcinoma, and infiltrating lobular carcinoma. Breast cancer can include Paget&#39;s disease, Paget&#39;s disease with intraductal carcinoma, and Paget&#39;s disease with invasive ductal carcinoma. Breast cancer can include breast neoplasms having histologic and ultrastructual heterogeneity (e.g., mixed cell types). 
     A breast cancer that is to be treated can include familial breast cancer. A breast cancer that is to be treated can include sporadic breast cancer. A breast cancer that is to be treated can arise in a male subject. A breast cancer that is to be treated can arise in a female subject. A breast cancer that is to be treated can arise in a premenopausal female subject or a postmenopausal female subject. A breast cancer that is to be treated can be in a pre-mastectomy female subject or a post-mastectomy female patient. 
     A breast cancer that is to be treated can include a localized tumor of the breast. A breast cancer that is to be treated can include a tumor of the breast that is associated with a negative sentinel lymph node (SLN) biopsy. A breast cancer that is to be treated can include a tumor of the breast that is associated with a positive sentinel lymph node (SLN) biopsy. A breast cancer that is to be treated can include a tumor of the breast that is associated with one or more positive axillary lymph nodes, where the axillary lymph nodes have been staged by any applicable method. A breast cancer that is to be treated can include a tumor of the breast that has been typed as having nodal negative status (e.g., node-negative) or nodal positive status (e.g., node-positive). A breast cancer that is to be treated can include a tumor of the breast that has been typed as being hormone receptor negative (e.g., estrogen receptor-negative) or hormone receptor positive status (e.g., estrogen receptor-positive). A breast cancer that is to be treated can include a tumor of the breast that has metastasized to other locations in the body. A breast cancer that is to be treated can be classified as having metastasized to a location selected from the group consisting of bone, lung, liver, lymph nodes, and brain. A breast cancer that is to be treated can be classified according to a characteristic selected from the group consisting of metastatic, localized, regional, local-regional, locally advanced, distant, multicentric, bilateral, ipsilateral, contralateral, newly diagnosed, recurrent, and inoperable. 
     For the purposes of the present disclosure, “a breast cancer treatment comprising radiation” is a breast cancer treatment that includes radiation therapy, radiation treatment or radiation exposure. A “breast cancer treatment comprising radiation” can also be a breast cancer treatment that includes other anti-cancer or chemotherapeutic agents. 
     For the purposes of the present disclosure, “a breast cancer treatment not comprising radiation” is a breast cancer treatment that does not include any radiation therapy, radiation treatment or radiation exposure. These treatments can contain other anti-cancer or chemotherapeutic agents. 
     By “prolong” is meant an increase in time relative to a reference, standard, or control condition. Time may be increased anywhere from 0.01% to 10,000%, e.g., 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 90%, 100%, 200%, 300%, 400%, 500%, 600%, 700%, 800%, 900%, 1,000%, 2,000%, 3,000%, 4,000%, 5,000%, 6,000%, 7,000%, 8,000%, 9,000%, and 10,000%. 
     The amount of radiation used in radiation therapy (e.g., photon radiation therapy) is measured in gray (Gy), and varies depending on the type and stage of cancer being treated. The total dose of radiation therapy can be between about 20 to about 80 Gy. A dose for a solid epithelial tumor ranges can be from about 60 to about 80 Gy. A dose for lymphomas can be from about 20 Gy to about 40 Gy. Preventative (adjuvant) doses can be about 40 Gy to about 60 Gy. Preferably, about 45 Gy to about 60 Gy. Preferably, radiation therapy is administered in about 1.5 Gy to about 2.0 Gy fractions. 
     The total dose is fractionated (spread out over time), which permits normal cells time to recover, while tumor cells are generally less efficient in repair between fractions. Fractionation also allows tumor cells that were in a relatively radio-resistant phase of the cell cycle during one treatment to cycle into a sensitive phase of the cycle before the next fraction is given. One fractionation schedule for adults can be about 1.8 to about 2.0 Gy per day, five days a week. One fractionation schedule for children can be about 1.5 to about 1.8 Gy per day. 
     Accelerated Partial Breast Irradiation (APBI) is another fraction schedule use to treat breast cancer. APBI can be performed with either brachytherapy or with external beam radiation. APBI normally involves two high-dose fractions per day for five days, compared to whole breast irradiation, in which a single, smaller fraction is given five times a week over a six-to-seven-week period. 
     Classes of anti-cancer or chemotherapeutic agents can include anthracycline agents, alkylating agents, nucleoside analogs, platinum agents, taxanes,  vinca  agents, anti-estrogen drugs, aromatase inhibitors, ovarian suppression agents, endocrine/hormonal agents, bisphophonate therapy agents and targeted biological therapy agents. 
     Specific anti-cancer or chemotherapeutic agents can include cyclophosphamide, fluorouracil (or 5-fluorouracil or 5-FU), methotrexate, thiotepa, carboplatin, cisplatin, anthracyclines, gemcitabine, taxanes, paclitaxel, protein-bound paclitaxel, docetaxel, vinorelbine, tamoxifen, raloxifene, toremifene, fulvestrant, irinotecan, ixabepilone, temozolmide, topotecan, vincristine, vinblastine, eribulin, mutamycin, capecitabine, capecitabine, anastrozole, exemestane, letrozole, leuprolide, abarelix, buserlin, goserelin, megestrol acetate, risedronate, pamidronate, ibandronate, alendronate, denosumab, zoledronate, trastuzumab, tykerb or bevacizumab, or combinations thereof; one such combination is CMF which includes cyclophosphamide, methotrexate, and fluorouracil. 
     Description of Intrinsic Subtype Biology 
     Luminal subtypes: The most common subtypes of breast cancer are the luminal subtypes, Luminal A and Luminal B. Prior studies suggest that Luminal A comprises approximately 30% to 40% and Luminal B approximately 20% of all breast cancers, but they represent over 90% of hormone receptor positive breast cancers (Nielsen et al.  Clin. Cancer Res.,  16(21):5222-5232 (2009)). The gene expression pattern of these subtypes resembles the luminal epithelial component of the breast. These tumors are characterized by high expression of estrogen receptor (ER), progesterone receptor (PR), and genes associated with ER activation, such as LIV1, GATA3, and cyclin D1, as well as expression of luminal cytokeratins 8 and 18 (Lisa Carey &amp; Charles Perou (2009). “Gene Arrays, Prognosis, and Therapeutic Interventions”. Jay R. Harris et al. (4th ed.), “Diseases of the breast” (pp. 458-472). Philadelphia, Pa.: Lippincott Williams &amp; Wilkins). 
     Luminal A: Luminal A (LumA) breast cancers exhibit low expression of genes associated with cell cycle activation and the ERBB2 cluster resulting in a better prognosis than Luminal B. The Luminal A subgroup has the most favorable prognosis of all subtypes and is enriched for endocrine therapy-responsive tumors. 
     Luminal B: Luminal B (LumB) breast cancers also express ER and ER-associated genes. Genes associated with cell cycle activation are highly expressed and this tumor type can be HER2(+) (˜20%) or HER2(−). The prognosis is unfavorable (despite ER expression) and endocrine therapy responsiveness is generally diminished relative to LumA. 
     HER2-enriched: The HER2-enriched subtype is generally ER-negative and is HER2-positive in the majority of cases with high expression of the ERBB2 cluster, including ERBB2 and GRB7. Genes associated with cell cycle activation are highly expressed and these tumors have a poor outcome. 
     Basal-like: The Basal-like subtype is generally ER-negative, is almost always clinically HER2-negative and expresses a suite of “Basal” biomarkers including the basal epithelial cytokeratins (CK) and epidermal growth factor receptor (EGFR). Genes associated with cell cycle activation are highly expressed. 
     Clinical Variables 
     The methods described herein, e.g., the PAM50 or NANO46 classification models, may be further combined with information on clinical variables (also referred to herein as “clinicopathological variables”) to generate a continuous risk of recurrence (ROR) predictor. As described herein, a number of clinical and prognostic breast cancer factors are known in the art and are used to predict treatment outcome and the likelihood of disease recurrence. Such factors include, for example, lymph node involvement, tumor size, histologic grade, estrogen and progesterone hormone receptor status, HER2 levels, and tumor ploidy. In one embodiment, risk of recurrence (ROR) score is provided for a subject diagnosed with or suspected of having breast cancer. This score uses an above-described classification model, e.g., the PAM50 or NANO46 classification models, in combination with clinical factors of lymph node status (N) and tumor size (T). Assessment of clinical variables is based on the American Joint Committee on Cancer (AJCC) standardized system for breast cancer staging. In this system, primary tumor size is categorized on a scale of 0-4 (T0: no evidence of primary tumor; T1: &lt;2 cm; T2: &gt;2 cm to &lt;5 cm; T3: &gt;5 cm; T4: tumor of any size with direct spread to chest wall or skin). Lymph node status is classified as N0-N3 (NO: regional lymph nodes are free of metastasis; N1: metastasis to movable, same-side axillary lymph node(s); N2: metastasis to same-side lymph node(s) fixed to one another or to other structures; N3: metastasis to same-side lymph nodes beneath the breastbone). Methods of identifying breast cancer patients and staging the disease are well known and may include manual examination, biopsy, review of patient&#39;s and/or family history, and imaging techniques, such as mammography, magnetic resonance imaging (MRI), and positron emission tomography (PET). 
     Sample Source 
     In one embodiment of the present disclosure, breast cancer subtype is assessed through the evaluation of expression patterns, or profiles, of the intrinsic genes listed in Table 1 in one or more subject samples and/or fluorescence in situ hybridization (FISH) analysis or immunohistochemistry (IHC) performed to ascertain the HER2 status of the cancer. As used herein, the term “subject” or “subject sample”, refers to an individual regardless of health and/or disease status. A subject can be a subject, a study participant, a control subject, a screening subject, or any other class of individual from whom a sample is obtained and assessed in the context of the disclosure. Accordingly, a subject can be diagnosed with breast cancer, can present with one or more symptoms of breast cancer, or a predisposing factor, such as a family (genetic) or medical history (medical) factor, for breast cancer, can be undergoing treatment or therapy for breast cancer, or the like. As such, the subject is a subject in need of treatment for breast cancer, detection of breast cancer, classification of a cancer, screening of likelihood of effectiveness of a treatment, and prediction of local-regional relapse free or breast cancer specific survival in response to a treatment. Alternatively, a subject can be healthy with respect to any of the aforementioned factors or criteria. It will be appreciated that the term “healthy” as used herein, is relative to breast cancer status, as the term “healthy” cannot be defined to correspond to any absolute evaluation or status. Thus, an individual defined as healthy with reference to any specified disease or disease criterion, can in fact be diagnosed with any other one or more diseases, or exhibit any other one or more disease criterion, including one or more cancers other than breast cancer. However, the healthy controls are preferably free of any cancer. 
     As used herein, a “subject in need thereof” is a subject having breast cancer or presenting with one or more symptoms of breast cancer, or a subject having an increased risk of developing breast cancer relative to the population at large. Preferably, a subject in need thereof has breast cancer. The breast cancer can be primary breast cancer, locally advanced breast cancer or metastatic breast cancer. A “subject” includes a mammal. The mammal can be any mammal, e.g., a human, a primate, a bird, a mouse, a rat, a fowl, a dog, a cat, a cow, a horse, a goat, a camel, a sheep and a pig. Preferably, the mammal is a human. The subject can be a male or a female. 
     In particular embodiments, the methods and kits for predicting breast cancer intrinsic subtypes or HER2 status (e.g., for predicting local-regional relapse free or breast cancer specific survival in a subject, for screening for the likelihood of the effectiveness of a post-mastectomy breast cancer treatment, and for treating breast cancer in a subject) include collecting a biological sample comprising a cancer cell or tissue, such as a breast tissue sample or a primary breast tumor tissue sample. By “biological sample” is intended any sampling of cells, tissues, or bodily fluids in which expression of an intrinsic gene can be detected. Examples of such biological samples include, but are not limited to, biopsies and smears. Bodily fluids useful in the present disclosure include blood, lymph, urine, saliva, nipple aspirates, gynecological fluids, or any other bodily secretion or derivative thereof. Blood can include whole blood, plasma, serum, or any derivative of blood. In some embodiments, the biological sample includes breast cells, particularly breast tissue from a biopsy, such as a breast tumor tissue sample. Biological samples may be obtained from a subject by a variety of techniques including, for example, by scraping or swabbing an area, by using a needle to aspirate cells or bodily fluids, or by removing a tissue sample (i.e., biopsy). Methods for collecting various biological samples are well known in the art. In some embodiments, a breast tissue sample is obtained by, for example, fine needle aspiration biopsy, core needle biopsy, or excisional biopsy. Fixative and staining solutions may be applied to the cells or tissues for preserving the specimen and for facilitating examination. Biological samples, particularly breast tissue samples, may be transferred to a glass slide for viewing under magnification. In one embodiment, the biological sample is a formalin fixed paraffin embedded (FFPE) breast tissue sample, particularly a primary breast tumor sample. In various embodiments, the tissue sample is obtained from a pathologist-guided tissue core sample. 
     Expression Profiling 
     In various embodiments, the present disclosure provides methods for classifying, prognosticating, or monitoring breast cancer in subjects. In this embodiment, data obtained from analysis of intrinsic gene expression is evaluated using one or more pattern recognition algorithms. See, as examples, U.S. Patent Application Publication Nos. 2011/0145176 and 2013/0337444. Such analysis methods may be used to form a predictive model, which can be used to classify test data. For example, one convenient and particularly effective method of classification employs multivariate statistical analysis modeling, first to form a model (a “predictive mathematical model”) using data (“modeling data”) from samples of known subtype (e.g., from subjects known to have a particular breast cancer intrinsic subtype: LumA, LumB, Basal-like, HER2-enriched, or normal-like), and second to classify an unknown sample (e.g., “test sample”) according to subtype. Pattern recognition methods have been used widely to characterize many different types of problems ranging, for example, over linguistics, fingerprinting, chemistry and psychology. In the context of the methods described herein, pattern recognition is the use of multivariate statistics, both parametric and non-parametric, to analyze data, and hence to classify samples and to predict the value of some dependent variable based on a range of observed measurements. There are two main approaches. One set of methods is termed “unsupervised” and these simply reduce data complexity in a rational way and also produce display plots which can be interpreted by the human eye. However, this type of approach may not be suitable for developing a clinical assay that can be used to classify samples derived from subjects independent of the initial sample population used to train the prediction algorithm. 
     The other approach is termed “supervised” whereby a training set of samples with known class or outcome is used to produce a mathematical model which is then evaluated with independent validation data sets. Here, a “training set” of intrinsic gene expression data is used to construct a statistical model that predicts correctly the “subtype” of each sample. This training set is then tested with independent data (referred to as a test or validation set) to determine the robustness of the computer-based model. These models are sometimes termed “expert systems,” but may be based on a range of different mathematical procedures. Supervised methods can use a data set with reduced dimensionality (for example, the first few principal components), but typically use unreduced data, with all dimensionality. In all cases the methods allow the quantitative description of the multivariate boundaries that characterize and separate each subtype in terms of its intrinsic gene expression profile. It is also possible to obtain confidence limits on any predictions, for example, a level of probability to be placed on the goodness of fit. The robustness of the predictive models can also be checked using cross-validation, by leaving out selected samples from the analysis. 
     The PAM50 or NANO46 classification models described herein (and as described in U.S. Patent Application Publication Nos. 2011/0145176 and 2013/0337444) is based on the gene expression profile for a plurality of subject samples using the 50 or 46, respectively, intrinsic genes listed in Table 1. The plurality of samples includes a sufficient number of samples derived from subjects belonging to each subtype class. By “sufficient samples” or “representative number” in this context is intended a quantity of samples derived from each subtype that is sufficient for building a classification model that can reliably distinguish each subtype from all others in the group. A supervised prediction algorithm is developed based on the profiles of objectively-selected prototype samples for “training” the algorithm. The samples are selected and subtyped using an expanded intrinsic gene set according to the methods disclosed in International Patent Publication WO 2007/061876 and U.S. Patent Publication No. 2009/0299640. Alternatively, the samples can be subtyped according to any known assay for classifying breast cancer subtypes. After stratifying the training samples according to subtype, a centroid-based prediction algorithm is used to construct centroids based on the expression profile of all or some of the intrinsic gene set described in Table 1. 
     In one embodiment, the prediction algorithm is the nearest centroid methodology related to that described in Narashiman and Chu (2002)  PNAS  99:6567-6572. In the present disclosure, the method computes a standardized centroid for each subtype. This centroid is the average gene expression for each gene in each subtype (or “class”) divided by the within-class standard deviation for that gene. Nearest centroid classification takes the gene expression profile of a new sample, and compares it to each of these class centroids. Subtype prediction is done by calculating the Spearman&#39;s rank correlation of each test case to the five centroids, and assigning a sample to a subtype based on the nearest centroid. 
     Detection of Intrinsic Gene Expression 
     Any methods available in the art for detecting expression of the intrinsic genes listed in Table 1 are encompassed herein. By “detecting expression” is intended determining the quantity or presence of an RNA transcript or its expression product of an intrinsic gene. Methods for detecting expression of the intrinsic genes of the disclosure, that is, gene expression profiling, include methods based on hybridization analysis of polynucleotides, methods based on sequencing of polynucleotides, immunohistochemistry methods, and proteomics-based methods. The methods generally detect expression products (e.g., mRNA) of the intrinsic genes listed in Table 1. In preferred embodiments, PCR-based methods, such as reverse transcription PCR (RT-PCR) (Weis et al.,  TIG  8:263-64, 1992), and array-based methods such as microarray (Schena et al.,  Science  270:467-70, 1995) are used. By “microarray” is intended an ordered arrangement of hybridizable array elements, such as, for example, polynucleotide probes, on a substrate. The term “probe” refers to any molecule that is capable of selectively binding to a specifically intended target biomolecule, for example, a nucleotide transcript or a protein encoded by or corresponding to an intrinsic gene. Probes can be synthesized by one of skill in the art, or derived from appropriate biological preparations. Probes may be specifically designed to be labeled. Examples of molecules that can be utilized as probes include, but are not limited to, RNA, DNA, proteins, antibodies, and organic molecules. 
     Many expression detection methods use isolated RNA. The starting material is typically total RNA isolated from a biological sample, such as a tumor or tumor cell line, and corresponding normal tissue or cell line, respectively. If the source of RNA is a primary tumor, RNA (e.g., mRNA) can be extracted, for example, from frozen or archived paraffin-embedded and fixed (e.g., formalin-fixed) tissue samples (e.g., pathologist-guided tissue core samples). 
     General methods for RNA extraction are well known in the art and are disclosed in standard textbooks of molecular biology, including Ausubel et al., ed., “Current Protocols in Molecular Biology”, John Wiley &amp; Sons, New York 1987-1999. Methods for RNA extraction from paraffin embedded tissues are disclosed, for example, in Rupp and Locker,  Lab Invest.  56:A67, (1987); and De Andres et al.  Biotechniques  18:42-44, (1995). In particular, RNA isolation can be performed using a purification kit, a buffer set and protease from commercial manufacturers, such as Qiagen (Valencia, Calif.), according to the manufacturer&#39;s instructions. For example, total RNA from cells in culture can be isolated using Qiagen RNeasy mini-columns. Other commercially available RNA isolation kits include Masterpure™ Complete DNA and RNA Purification Kit (Epicentre®, Madison, Wis.) and Paraffin Block RNA Isolation Kit (Ambion®, Austin, Tex.). Total RNA from tissue samples can be isolated, for example, using RNA Stat-60 (Tel-Test, Friendswood, Tex.). RNA prepared from a tumor can be isolated, for example, by cesium chloride density gradient centrifugation. Additionally, large numbers of tissue samples can readily be processed using techniques well known to those of skill in the art, such as, for example, the single-step RNA isolation process of Chomczynski (U.S. Pat. No. 4,843,155). 
     Isolated RNA can be used in hybridization or amplification assays that include, but are not limited to, PCR analyses and probe arrays. One method for the detection of RNA levels involves contacting the isolated RNA with a nucleic acid molecule (probe) that can hybridize to the mRNA encoded by the gene being detected. The nucleic acid probe can be, for example, a full-length cDNA, or a portion thereof, such as an oligonucleotide of at least 7, 15, 30, 60, 100, 250, or 500 nucleotides in length and sufficient to specifically hybridize under stringent conditions to an intrinsic gene of the present disclosure, or any derivative DNA or RNA. Hybridization of an mRNA with the probe indicates that the intrinsic gene in question is being expressed. The term “stringent conditions” is as well-known in the art and as described, at least, in books, publications and patent documents listed herein. 
     In one embodiment, the mRNA is immobilized on a solid surface and contacted with a probe, for example by running the isolated mRNA on an agarose gel and transferring the mRNA from the gel to a membrane, such as nitrocellulose. In an alternative embodiment, the probes are immobilized on a solid surface and the mRNA is contacted with the probes, for example, in an Agilent (Santa Clara, Calif.) gene chip array. A skilled artisan can readily adapt known mRNA detection methods for use in detecting the level of expression of the intrinsic genes of the present disclosure. 
     An alternative method for determining the level of intrinsic gene expression product in a sample involves the process of nucleic acid amplification, for example, by RT-PCR (U.S. Pat. No. 4,683,202), ligase chain reaction (Barany,  PNAS USA  88: 189-93, (1991)), self-sustained sequence replication (Guatelli et al.,  PNAS USA  87: 1874-78, (1990)), transcriptional amplification system (Kwoh et al.,  PNAS USA  86: 1173-77, (1989)), Q-Beta Replicase (Lizardi et al.,  Bio/Technology  6:1197, (1988)), rolling circle replication (U.S. Pat. No. 5,854,033), or any other nucleic acid amplification method, followed by the detection of the amplified molecules using techniques well known to those of skill in the art. These detection schemes are especially useful for the detection of nucleic acid molecules if such molecules are present in very low numbers. 
     In particular aspects of the disclosure, intrinsic gene expression can assessed by quantitative RT-PCR. Numerous different PCR or quantitative real-time PCR (qPCR) protocols are known in the art and exemplified herein and can be directly applied or adapted for use using the presently-described methods and kits for the detection and/or quantification of the intrinsic genes listed in Table 1. Generally, in PCR, a target polynucleotide sequence is amplified by reaction with at least one oligonucleotide primer or a pair of oligonucleotide primers. The primer(s) hybridize to a complementary region of the target nucleic acid and a DNA polymerase extends the primer(s) to amplify the target sequence. Under conditions sufficient to provide polymerase-based nucleic acid amplification products, a nucleic acid fragment of one size dominates the reaction products (the target polynucleotide sequence which is the amplification product). The amplification cycle is repeated to increase the concentration of the single target polynucleotide sequence. The reaction can be performed in any thermocycler commonly used for PCR. However, preferred are cyclers with real time fluorescence measurement capabilities, for example, Smartcycler® (Cepheid, Sunnyvale, Calif.), ABI Prism 7700® (Applied Biosystems®, Foster City, Calif.), Rotor-Gene™ (Corbett Research, Sydney, Australia), Lightcycler® (Roche Diagnostics Corp, Indianapolis, Ind.), iCycler® (Biorad Laboratories, Hercules, Calif.) and MX4000® (Stratagene, La Jolla, Calif.). 
     In another embodiment of the disclosure, microarrays are used for expression profiling. Microarrays are particularly well suited for this purpose because of the reproducibility between different experiments. DNA microarrays provide one method for the simultaneous measurement of the expression levels of large numbers of genes. Each array consists of a reproducible pattern of capture probes attached to a solid support. Labeled RNA or DNA is hybridized to complementary probes on the array and then detected by laser scanning Hybridization intensities for each probe on the array are determined and converted to a quantitative value representing relative gene expression levels. See, for example, U.S. Pat. Nos. 6,040,138, 5,800,992 and 6,020,135, 6,033,860, and 6,344,316. High-density oligonucleotide arrays are particularly useful for determining the gene expression profile for a large number of RNAs in a sample. 
     In a preferred embodiment, the nCounter® Analysis System (NanoString Technologies, Seattle, Wash.) is used to detect intrinsic gene expression. The basis of the nCounter® Analysis System is the unique code assigned to each nucleic acid target to be assayed (International Patent Application Publication No. WO 08/124847, U.S. Pat. No. 8,415,102 and Geiss et al.  Nature Biotechnology.  2008. 26(3): 317-325). The code is composed of an ordered series of colored fluorescent spots which create a unique barcode for each target to be assayed. A pair of probes is designed for each DNA or RNA target, a biotinylated capture probe and a reporter probe carrying the fluorescent barcode. This system is also referred to, herein, as the nanoreporter code system. 
     Specific reporter and capture probes are synthesized for each target. The reporter probe can comprise at a least a first label attachment region to which are attached one or more label monomers that emit light constituting a first signal; at least a second label attachment region, which is non-over-lapping with the first label attachment region, to which are attached one or more label monomers that emit light constituting a second signal; and a first target-specific sequence. Preferably, each sequence specific reporter probe comprises a target specific sequence capable of hybridizing to no more than one gene of Table 1 and optionally comprises at least three, or at least four label attachment regions, said attachment regions comprising one or more label monomers that emit light, constituting at least a third signal, or at least a fourth signal, respectively. The capture probe can comprise a second target-specific sequence; and a first affinity tag. In some embodiments, the capture probe can also comprise one or more label attachment regions. Preferably, the first target-specific sequence of the reporter probe and the second target-specific sequence of the capture probe hybridize to different regions of the same gene of Table 1 to be detected. Reporter and capture probes are all pooled into a single hybridization mixture, the “probe library”. Preferably, the probe library comprises a probe pair (a capture probe and reporter) for each of the genes in Table 1. Preferably, the probe library comprises a probe pair (a capture probe and reporter) for each of the NANO46 genes as described above. Preferably, the probe library comprises a probe pair (a capture probe and reporter) for each of the housekeeping genes and other genes described herein, e.g., Her2. 
     The relative abundance of each target is measured in a single multiplexed hybridization reaction. The method comprises contacting a biological sample with a probe library, the library comprising a probe pair for each of the at least 40 genes in Table 1, e.g., each of the NANO46 or PAM50 genes, and/or the housekeeping genes and other genes described herein, such that the presence of each target in the sample creates a probe pair-target complex. The complex is then purified. More specifically, the sample is combined with the probe library, and hybridization occurs in solution. After hybridization, the tripartite hybridized complexes (probe pairs and target) are purified in a two-step procedure using magnetic beads linked to oligonucleotides complementary to universal sequences present on the capture and reporter probes. This dual purification process allows the hybridization reaction to be driven to completion with a large excess of target-specific probes, as they are ultimately removed, and, thus, do not interfere with binding and imaging of the sample. All post hybridization steps are handled robotically on a custom liquid-handling robot (Prep Station, NanoString Technologies). 
     Purified reactions are deposited by the Prep Station into individual flow cells of a sample cartridge, bound to a streptavidin-coated surface via the capture probe, electrophoresed to elongate the reporter probes, and immobilized. After processing, the sample cartridge is transferred to a fully automated imaging and data collection device (Digital Analyzer, NanoString Technologies). The expression level of a target is measured by imaging each sample and counting the number of times the code for that target is detected. For each sample, typically 600 fields-of-view (FOV) are imaged (1376×1024 pixels) representing approximately 10 mm 2  of the binding surface. Typical imaging density is 100-1200 counted reporters per field of view depending on the degree of multiplexing, the amount of sample input, and overall target abundance. Data is output in simple spreadsheet format listing the number of counts per target, per sample. 
     This system can be used along with nanoreporters. Additional disclosure regarding nanoreporters can be found in International Publication No. WO 07/076129 and WO 07/076132, and US Patent Publication No. 2010/0015607 and 2010/0261026. Further, the term nucleic acid probes and nanoreporters can include the rationally designed (e.g., synthetic sequences) described in International Publication No. WO 2010/019826 and US Patent Publication No. 2010/0047924. 
     Data Processing 
     It is often useful to pre-process gene expression data, for example, by addressing missing data, translation, scaling, normalization, and weighting. Multivariate projection methods, such as principal component analysis (PCA) and partial least squares analysis (PLS), are so-called scaling sensitive methods. By using prior knowledge and experience about the type of data studied, the quality of the data prior to multivariate modeling can be enhanced by scaling and/or weighting. Adequate scaling and/or weighting can reveal important and interesting variation hidden within the data, and therefore make subsequent multivariate modeling more efficient. Scaling and weighting may be used to place the data in the correct metric, based on knowledge and experience of the studied system, and therefore reveal patterns already inherently present in the data. 
     If possible, missing data, for example gaps in column values, should be avoided. However, if necessary, such missing data may be replaced or “filled” with, for example, the mean value of a column (“mean fill”); a random value (“random fill”); or a value based on a principal component analysis (“principal component fill”). 
     “Translation” of the descriptor coordinate axes can be useful. Examples of such translation include normalization and mean centering. “Normalization” may be used to remove sample-to-sample variation. For microarray data, the process of normalization aims to remove systematic errors by balancing the fluorescence intensities of the two labeling dyes. The dye bias can come from various sources including differences in dye labeling efficiencies, heat and light sensitivities, as well as scanner settings for scanning two channels. Some commonly used methods for calculating normalization factor include: (i) global normalization that uses all genes on the array; (ii) housekeeping genes normalization that uses constantly expressed housekeeping/invariant genes; and (iii) internal controls normalization that uses known amount of exogenous control genes added during hybridization (Quackenbush,  Nat. Genet.  32 (Suppl.), 496-501 (2002)). In one embodiment, the intrinsic genes disclosed herein can be normalized to control housekeeping genes. For example, the housekeeping genes described in U.S. Patent Publication 2008/0032293 can be used for normalization. Exemplary housekeeping genes include MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLPO, and TFRC. It will be understood by one of skill in the art that the methods disclosed herein are not bound by normalization to any particular housekeeping genes, and that any suitable housekeeping gene(s) known in the art can be used. 
     Many normalization approaches are possible, and they can often be applied at any of several points in the analysis. In one embodiment, microarray data is normalized using the LOWESS method, which is a global locally weighted scatterplot smoothing normalization function. In another embodiment, qPCR data is normalized to the geometric mean of set of multiple housekeeping genes. 
     “Mean centering” may also be used to simplify interpretation. Usually, for each descriptor, the average value of that descriptor for all samples is subtracted. In this way, the mean of a descriptor coincides with the origin, and all descriptors are “centered” at zero. In “unit variance scaling,” data can be scaled to equal variance. Usually, the value of each descriptor is scaled by 1/StDev, where StDev is the standard deviation for that descriptor for all samples. “Pareto scaling” is, in some sense, intermediate between mean centering and unit variance scaling. In Pareto scaling, the value of each descriptor is scaled by 1/sqrt(StDev), where StDev is the standard deviation for that descriptor for all samples. In this way, each descriptor has a variance numerically equal to its initial standard deviation. The Pareto scaling may be performed, for example, on raw data or mean centered data. 
     “Logarithmic scaling” may be used to assist interpretation when data have a positive skew and/or when data spans a large range, e.g., several orders of magnitude. Usually, for each descriptor, the value is replaced by the logarithm of that value. In “equal range scaling,” each descriptor is divided by the range of that descriptor for all samples. In this way, all descriptors have the same range, that is, 1. However, this method is sensitive to presence of outlier points. In “autoscaling,” each data vector is mean centered and unit variance scaled. This technique is very useful because each descriptor is then weighted equally, and large and small values are treated with equal emphasis. This can be important for genes expressed at very low, but still detectable, levels. 
     In one embodiment, data is collected for one or more test samples and classified using the at least 40 genes of Table 1 as described herein, e.g., the PAM50 or NANO46 classification models. When comparing data from multiple analyses (e.g., comparing expression profiles for one or more test samples to the centroids constructed from samples collected and analyzed in an independent study), it will be necessary to normalize data across these data sets. In one embodiment, Distance Weighted Discrimination (DWD) is used to combine these data sets together (Benito et al. (2004)  Bioinformatics  20(1): 105-114). DWD is a multivariate analysis tool that is able to identify systematic biases present in separate data sets and then make a global adjustment to compensate for these biases; in essence, each separate data set is a multi-dimensional cloud of data points, and DWD takes two points clouds and shifts one such that it more optimally overlaps the other. 
     The methods described herein may be implemented and/or the results recorded using any device capable of implementing the methods and/or recording the results. Examples of devices that may be used include but are not limited to electronic computational devices, including computers of all types. When the methods described herein are implemented and/or recorded in a computer, the computer program that may be used to configure the computer to carry out the steps of the methods may be contained in any computer readable medium capable of containing the computer program. Examples of computer readable medium that may be used include but are not limited to diskettes, CD-ROMs, DVDs, ROM, RAM, non-transitory computer-readable media, and other memory and computer storage devices. The computer program that may be used to configure the computer to carry out the steps of the methods and/or record the results may also be provided over an electronic network, for example, over the internet, an intranet, or other network. 
     Calculation of Risk of Recurrence 
     Provided herein are methods for predicting breast cancer outcome within the context of the intrinsic subtype and optionally other clinical variables. Outcome may refer to overall or disease-specific survival, event-free survival, or outcome in response to a particular treatment or therapy. In particular, the methods may be used to predict the likelihood of long-term, disease-free survival. “Predicting the likelihood of survival of a breast cancer patient” is intended to assess the risk that a patient will die as a result of the underlying breast cancer. “Long-term, disease-free survival” is intended to mean that the patient does not die from or suffer a recurrence of the underlying breast cancer within a period of at least five years, or at least ten or more years, following initial diagnosis or treatment. 
     In embodiments, outcome is predicted based on classification of a subject according to cancer subtype. This classification is based on expression profiling using the at least 40 intrinsic genes listed in Table 1. In addition to providing a subtype assignment, the at least 40 intrinsic genes listed in Table 1, e.g., the PAM50 or NANO46 genes, provide measurements of the similarity of a test sample to all four subtypes which is translated into a Risk of Recurrence (ROR) score that can be used in any patient population regardless of disease status and treatment options. The intrinsic subtypes and ROR also have value in the prediction of pathological complete response in women treated with, for example, neoadjuvant taxane and anthracycline chemotherapy (Rouzier et al.,  J Clin Oncol  23:8331-9 (2005)). Thus, in various embodiments of the present disclosure, a risk of recurrence (ROR) model is used to predict outcome. Using these risk models, subjects can be stratified into low, medium, and high risk of recurrence groups. Calculation of ROR can provide prognostic information to guide treatment decisions and/or monitor response to therapy. 
     In some embodiments described herein, the prognostic performance of the intrinsic subtypes defied by expression profiles of the at least 40 genes listed in Table 1, e.g., the PAM50- or NANO46-defined intrinsic subtypes, and/or other clinical parameters is assessed utilizing a Cox Proportional Hazards Model Analysis, which is a regression method for survival data that provides an estimate of the hazard ratio and its confidence interval. The Cox model is a well-recognized statistical technique for exploring the relationship between the survival of a patient and particular variables. This statistical method permits estimation of the hazard (i.e., risk) of individuals given their prognostic variables (e.g., intrinsic gene expression profile with or without additional clinical factors, as described herein). The “hazard ratio” is the risk of death at any given time point for patients displaying particular prognostic variables. See generally Spruance et al.,  Antimicrob. Agents  &amp;  Chemo.  48:2787-92 (2004). 
     The classification models described herein, e.g., the PAM50 or NANO46 classification models, can be trained for risk of recurrence using subtype distances (or correlations) alone, or using subtype distances with clinical variables as discussed supra. In one embodiment, the risk score for a test sample is calculated using intrinsic subtype distances alone using the following equation (Equation 2): 
       ROR=0.05*Basal+0.1 l*HER2+−0.25*LumA+0.07*LumB+−0.1 l*Normal,
         where the variables “Basal,” “HER2,” “LumA,” “LumB,” and “Normal” are the distances to the centroid for each respective classifier when the expression profile from a test sample is compared to centroids constructed using the gene expression data deposited with the National Center for Biotechnology Information Gene Expression Omnibus (GEO); as examples with accession number GSE2845 or GSE10886.       

     Risk score can also be calculated using a combination of breast cancer subtype and the clinical variables tumor size (T) and lymph nodes status (N) using the following equation (Equation 3): 
       ROR(full)=0.05*Basal+0.1*HER2+−0.19*LumA+0.05*LumB+−0.09*Normal+0.16 *T+ 0.08 *N,  
         where the variables “Basal,” “HER2,” “LumA,” and “LumB” are as described supra and when comparing test expression profiles to centroids constructed using the gene expression data deposited with GEO; as examples with accession number GSE2845 or GSE10886.       

     In yet another embodiment, risk score for a test sample is calculated using intrinsic subtype distances alone using the following equation (Equation 4): 
       ROR-S=0.05*Basal+0.12*HER2+−0.34*LumA+0.0.23*LumB,
         where the variables “Basal,” “HER2,” “LumA,” and “LumB” are as described supra and the test expression profiles are compared to centroids constructed using the gene expression data deposited with GEO; as examples with accession number GSE2845 or GSE10886.       

     In yet another embodiment, risk score can also be calculated using a combination of breast cancer subtype and the clinical variable tumor size (T) using the following equation (Equation 5): 
       ROR-C=0.05*Basal+0.1 l*HER2+−0.23*LumA+0.09*LumB+0.17 *T,  
         where the variables “Basal,” “HER2,” “LumA,” and “LumB” are as described supra and the test expression profiles are compared to centroids constructed using the gene expression data deposited with GEO; as examples with accession number GSE2845 or GSE10886.       

     In yet another embodiment, risk score for a test sample is calculated using intrinsic subtype distances in combination with the proliferation signature (“Prolif”) using the following equation (Equation 6): 
       ROR-P=−0.001*Basal+0.7*HER2+−0.95*LumA+0.49*LumB+0.34*Prolif,
         where the variables “Basal,” “HER2,” “LumA,” “LumB” and “Prolif” are as described supra and the test expression profiles are compared to centroids constructed using the gene expression data deposited with GEO; as examples with accession number GSE2845 or GSE10886.       

     In yet another embodiment, risk score can also be calculated using a combination of breast cancer subtype, proliferation signature and the clinical variable tumor size (T) using the ROR-PT described in conjunction with Table 5, supra. 
     Detection of Subtypes 
     Immunohistochemistry (IHC) for estrogen receptor (ER), progesterone receptor (PR), HER2, and Ki67 can be performed concurrently on serial sections with the standard streptaviding biotin complex method with 3,3′-diaminobenzidine as the chromogen. Staining for ER, PR, and HER2 interpretation can be performed as described previously (Cheang et al.,  Clin Cancer Res.  2008; 14(5):1368-1376), however any method known in the art may be used. 
     For example, a Ki67 antibody (clone SP6; ThermoScientific™, Fremont, Calif.) can be applied at a 1:200 dilution for 32 minutes, by following the Ventana Benchmark automated immunostainer (Ventana®, Tucson, Ariz.) standard Cell Conditioner 1 (CC1, a proprietary buffer) protocol at 98° C. for 30 minutes. An ER antibody (clone SP1; ThermoFisher Scientific™) can be used at 1:250 dilution with 10-minute incubation, after an 8-minute microwave antigen retrieval in 10 mM sodium citrate (pH 6.0). Ready-to-use PR antibody (clone 1E2; Ventana®) can be used by following the CC1 protocol as above. HER2 staining can be done with a SP3 antibody (ThermoFisher Scientific™) at a 1:100 dilution after antigen retrieval in 0.05 M Tris buffer (pH 10.0) with heating to 95° C. in a steamer for 30 minutes. For HER2 fluorescent in situ hybridization (FISH) assay, slides can be hybridized with probes to LSI (locus-specific identifier) HER2/neu and to centromere 17 by use of the PathVysion HER-2 DNA Probe kit (Abbott Molecular, Abbott Park, Ill.) according to manufacturer&#39;s instructions, with modifications to pretreatment and hybridization as previously described (Brown L A, Irving J, Parker R, et al. “Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas”.  Gynecol Oncol.  2006; 100(2):264-270). Slides can then be counterstained with 4′,6-diamidino-2-phenylindole. Stained material can be visualized on a Zeiss Axioplan epifluorescent microscope, and signals analyzed with a Metafer image acquisition system (Metasystems, Altlussheim, Germany). Biomarker expression from immunohistochemistry assays can then be scored by two pathologists, who are blinded to the clinicopathological characteristics and outcome and who used previously established and published criteria for biomarker expression levels that had been developed on other breast cancer cohorts. 
     Tumors are considered positive for ER or PR if immunostaining is observed in more than 1% of tumor nuclei, as described previously. Tumors are considered positive for HER2 if immunostaining is scored as 3+ according to HercepTest™ (Dako, Carpinteria, Calif.) criteria, with an amplification ratio for fluorescent in situ hybridization of 2.0 or more being the cut point that can be used to segregate immunohistochemistry equivocal tumors (scored as 2+) (Yaziji, et al.,  JAMA,  291(16):1972-1977 (2004)). Ki67 can be visually scored for percentage of tumor cell nuclei with positive immunostaining above the background level. 
     Other methods can also be used to detect the HER2+ subtype. These techniques include enzyme-linked immunosorbent assay (ELISA), Western blots, Northern blots, or fluorescence-activated cell sorting (FACS) analysis. 
     Kits 
     The present disclosure also describes kits useful for classifying breast cancer intrinsic subtypes and/or providing prognostic information to identify breast cancers that are more or less responsive to radiation. These kits comprise a set of reporter/capture probes and/or primers specific for the genes listed in Table 1, and/or housekeeping genes, and/or other genes descrbed herein. The kits can further include instructions for detecting the aforementioned genes and classifying breast cancer intrinsic subtypes and/or providing prognostic information to identify breast cancers that are more responsive to radiation. The kits may include instructions for recommended treatments based on a classified breast cancer intrinsic subtype. The kits may also contain reagents sufficient to facilitate detection and/or quantitation of HER2, in order to classify cells as HER2+. Preferably, the kit comprises a set of reporter/capture probes and/or primers specific for at least 10, at least 15, at least 20, at least 25, at least 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or all 50 genes listed in Table 1. The kit may further comprise a non-transitory computer readable medium. 
     In embodiments of the present disclosure, the capture probes are immobilized on an array. By “array” is intended a solid support or a substrate with peptide or nucleic acid probes attached to the support or substrate. Arrays typically comprise a plurality of different capture probes that are coupled to a surface of a substrate in different, known locations. The arrays of the disclosure comprise a substrate having a plurality of capture probes that can specifically bind an intrinsic gene expression product. The number of capture probes on the substrate varies with the purpose for which the array is intended. The arrays may be low-density arrays or high-density arrays and may contain 4 or more, 8 or more, 12 or more, 16 or more, 32 or more addresses, but will minimally comprise capture probes for at least 10, at least 15, at least 20, at least 25, or at least 46 of the intrinsic genes or all 50 intrinsic genes listed in Table 1. The array may include capture probes for the housekeeping genes and/or other genes listed herein. 
     Techniques for the synthesis of these arrays using mechanical synthesis methods are described in, e.g., U.S. Pat. No. 5,384,261. The array may be fabricated on a surface of virtually any shape or even a multiplicity of surfaces. Arrays may be probes (e.g., nucleic-acid binding probes) on beads, gels, polymeric surfaces, fibers such as fiber optics, glass or any other appropriate substrate, see U.S. Pat. Nos. 5,770,358, 5,789,162, 5,708,153, 6,040,193 and 5,800,992. Arrays may be packaged in such a manner as to allow for diagnostics or other manipulation on the device. See, for example, U.S. Pat. Nos. 5,856,174 and 5,922,591. 
     In embodiments, the kit comprises a set of oligonucleotide primers sufficient for the detection and/or quantitation of each of the intrinsic genes listed in Table 1. Preferably, the kit comprises a set of oligonucleotide primers sufficient for the detection and/or quantitation of at least 10, at least 15, at least 20, at least 25, at least 46 of the intrinsic genes or all 50 intrinsic genes listed in Table 1 and/or for the detection and/or quantitation of the housekeeping genes and/or other genes listed herein. The oligonucleotide primers may be provided in a lyophilized or reconstituted form, or may be provided as a set of nucleotide sequences. In certain embodiments, the primers are provided in a microplate format, where each primer set occupies a well (or multiple wells, as in the case of replicates) in the microplate. The microplate may further comprise primers sufficient for the detection of one or more housekeeping genes (e.g., eight) as discussed herein. The kit may further comprise reagents and instructions sufficient for the amplification of expression products from the genes listed in Table 1 and/or for the amplification of expression products from the housekeeping genes and/or other genes listed herein. 
     In order to facilitate ready access, e.g., for comparison, review, recovery, and/or modification, the molecular signatures/expression profiles are typically recorded in a database. Most typically, the database is a relational database accessible by a computational device, although other formats, e.g., manually accessible indexed files of expression profiles as photographs, analogue or digital imaging readouts, and spreadsheets can be used. Regardless of whether the expression patterns initially recorded are analog or digital in nature, the expression patterns, expression profiles (collective expression patterns), and molecular signatures (correlated expression patterns) are stored digitally and accessed via a database. Typically, the database is compiled and maintained at a central facility, with access being available locally and/or remotely. 
     In certain embodiments, the kit also includes a substance that is used to find the expression level of HER2. This substance can be an antibody or a nucleic acid probe. These substances can be used to detect HER2 using FISH, IHC, ELISA, Western blots, Northern blots, or FACS analysis. Optionally, the kit also includes reagents that allows for the detection of the detecting substance and the quantitation of HER2 expression in a sample. 
     Examples 
     Example 1 
     Background 
     Luminal A (LumA) tumors are associated with good prognosis, but with substantial risk for late loco-regional relapses. Here was tested the predictive value of intrinsic subtypes as defined by research-based PAM50 classifier, for predicting adjuvant radiation therapy benefit among pre-menopausal women with node positive tumors from a post mastectomy randomized adjuvant radiation trials with more than 20 years follow-up. 
     Methods: 
     Formalin fixed paraffin embedded tissues (FFPE) (n=145) were collected from the British Columbia trial and gene expression profiles were done using Nanostring nCounter® for FFPE samples. Tumors were classified into subtypes (Luminal A (LumA), Luminal B (LumB), HER2-enriched (HER2-E), Basal-like (BLBC) and Normal-like) based on the PAM50 classifier. Kaplan-Meier analysis and the log-rank test were used to test the differences in local-regional relapse free survival (LRFS) and breast cancer specific survival (BCSS). 
     RNA can be extracted from Formalin-fixed, Paraffin-embedded (FFPE) tissue that has been diagnosed as having a carcinoma of the breast. A Pathologist reviews a hematoxylin and eosin stain (H &amp; E) stained slide to identify the tissue area containing sufficient tumor tissue content for the test. Unstained slide mounted tissue sections are processed by macro-dissecting the identified tumor area on each slide to remove any adjacent normal tissue. RNA is then isolated from the tumor tissue, and DNA is removed from the sample. 
     Total RNA was extracted using the High Pure RNA Paraffin Kit (Roche Applied Science, Indianapolis, Ind., cat#03270289001), according to the manufacturer&#39;s protocol. RNA yield and purity were assessed using the NanoDrop ND-1000 Spectrophotometer (NanoDrop Technologies, Rockland, Del.). RNA samples used in downstream analysis met pre-specified quality criteria of an initial concentration of total RNA≧12.5 ng/μl, a minimum total yield of 250 ng, and a purity ratio in the range 1.7-2.5. 
     Gene expression was measured on the NanoString nCounter® Analysis System which delivers direct, multiplexed measurements through digital readouts of the relative abundance of hundreds of mRNA transcripts. In brief, the expression of the fifty target genes of Table 1 (PAM50) as well as normalizing “housekeeping” genes (for example MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPDH, GUSB, RPLPO, and TFRC) were measured in a single hybridization reaction without the use of any enzymatic reactions. An nCounter® CodeSet with gene-specific probe-pairs to the PAM50 targets as well as exogenous positive and negative controls was hybridized in solution to 125-500 ng total RNA (nominally 250 ng). After overnight hybridization, the samples were processed using the NanoString nCounter® Prep Station and Digital Analyzer according to the instructions and kits provided by NanoString Technologies. Data from each sample were qualified using prospectively defined quality control metrics for the positive and negative controls included in each reaction. 
     Intrinsic subtype classification of qualified patient samples was based upon the PAM50 gene expression signature. Reporter-code-count files, containing the digital abundance or “counts” of each target mRNA molecule for every sample, were sent to NanoString Technologies for PAM50 subtype calling using a prospectively defined and locked proprietary algorithm. Assignment of subtypes was performed in a blinded fashion, by researchers with no access to information regarding the clinical parameters or outcomes. 
     Results: 
     In this trial, patients received adjuvant CMF (cyclophosphamide, methotrexate, and fluorouracil) and were randomized to with or without post mastectomy radiation therapy (RT) groups. Patients with estrogen receptor positive tumor, as defined by the dextran charcoal biochemical assay, were randomized selected to receive oophorectomy and 42 of them were included in this correlative science study.  FIG. 1A  shows loco-regional relapse for subjects whose tumor samples are classified as Luminal A, with or without radiation therapy.  FIG. 1B  shows breast cancer specific survival (BCSS) for subjects whose tumor samples are classified as Luminal A, with or without radiation therapy.  FIG. 2A  shows loco-regional relapse for subjects whose tumor samples are classified as Luminal B, with or without radiation therapy.  FIG. 2B  shows breast cancer specific survival (BCSS) for subjects whose tumor samples are classified as Luminal B, with or without radiation therapy.  FIG. 3A  shows loco-regional relapse for subjects whose tumor samples are classified as HER2-enriched, with or without radiation therapy.  FIG. 3B  shows breast cancer specific survival (BCSS) for subjects whose tumor samples are classified as HER2-enriched, with or without radiation therapy.  FIG. 4A  shows loco-regional relapse for subjects whose tumor samples are classified as Basal-like, with or without radiation therapy.  FIG. 4B  shows breast cancer specific survival (BCSS) for subjects whose tumor samples are classified as Basal-like, with or without radiation therapy. 
       FIG. 5  shows a subpopulation treatment effect pattern plot (STEPP) showing 10-year breast cancer specific survival (BCSS) to the Spearman&#39;s correlation to Basal-like tumors average expression profile. 
       FIG. 6A  shows loco-regional relapse for subjects who are classified as low risk based on their Risk of Recurrence Score (subtypes centroid based), ROR-S, with or without radiation therapy.  FIG. 6B  shows breast cancer specific survival (BCSS) for subjects who are classified as low risk based on their Risk of Recurrence Score (subtypes centroid based), ROR-S, with or without radiation therapy.  FIG. 7A  shows loco-regional relapse for subjects who are classified as moderate/intermediate risk based on their Risk of Recurrence Score (subtypes centroid based), ROR-S, with or without radiation therapy.  FIG. 7B  shows breast cancer specific survival (BCSS) for subjects who are classified as moderate/intermediate risk based on their Risk of Recurrence Score (subtypes centroid based), ROR-S, with or without radiation therapy.  FIG. 8A  shows loco-regional relapse for subjects who are classified as high risk based on their Risk of Recurrence Score (subtypes centroid based), ROR-S, with or without radiation therapy.  FIG. 8B  shows breast cancer specific survival (BCSS) for subjects who are classified as high risk based on their Risk of Recurrence Score (subtypes centroid based), ROR-S, with or without radiation therapy. 
     These results demonstrate improved breast cancer specific survival (BCSS) for tumor samples classified as Basal-like subtype and have classified as ROR-S high risk and also demonstrate improved loco-regional relapse survival for tumor samples classified as Luminial A subtype and classified as ROR-S low risk. 
     Example 2 
     Herein an aim was to investigate the predictive value of additional genomic profiles (continuous measurements instead of subgroup analysis) for loco-regional recurrences (LRR) and breast cancer survival (BCSS) in node-positive, pre-menopausal breast cancer patients randomized to adjuvant chemoradiation or chemotherapy alone, in the British Columbia trial. 
     Methods: In the British Columbia trial, 318 patients received adjuvant cyclophosphamide, methotrexate, fluorouracil (CMF) and were randomized to with or without postmastectomy RT groups. From 145 formalin fixed paraffin embedded tissues, expression profiling of 66 genes was done with the Nanostring nCounter® Subpopulation Treatment Effect Pattern Plot analysis and permutation tests were used to examine treatment effects on LRR and BCSS events for the absolute difference (Kaplan-Meier) and relative effectiveness (Hazard Ratio) terms. For each tumor, the research-based PAM50 proliferation score, a Spearman&#39;s correlation to each of the four intrinsic subtypes (i.e., a quantitative measurement of similarity to the average expression profiles of a typical HER2-Enriched, Basal-like, Luminal A and Luminal B), Risk of Recurrence scores (ROR) and a 13-gene VEGF-signature score (VEGF-s) were calculated as previously described (Parker et al,  J. Clin. Oncol.,  27(8):1160-7 (2009); Hu et at  BMC Medicine,  7:9 2009). Expression level of DNA repair genes (RAD17 and RAD50) and tumor suppressor RB1 were also measured. 
     Results: Overall, patients in the RT arm (n=69) were significantly associated with better LRR and BCSS than the non-RT-treated arm (n=76). No significant treatment-effect heterogeneity was detected for VEGF-s, RAD17 and RAD50 expressions. On the other hand, patients with lower RB1 expression levels and higher proliferation scores had better LRR survival when assigned the RT (See, Table 9) respectively. The patters of treatment efficacy on LRR and BCSS were most heterogeneous for the varying levels of risk of recurrence scores particularly for patients with higher ROR-C (i.e., intrinsic subtypes centroids and tumor size) (See, Table 9) had poorest prognosis, but may benefit from adjuvant RT. 
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                 Subpopulation treatment effect pattern plot analysis of the treatment effect 
               
               
                 of RT versus no RT as measured by 10-year and 20-yr LRR and BCSS. 
               
            
           
           
               
               
               
               
            
               
                   
                   
                 LRR 
                 BCSS 
               
               
                   
                 Treatment-covariate 
                 (n = 145) 
                 (n = 145) 
               
            
           
           
               
               
               
               
               
               
            
               
                 Covariate 
                 interaction test 
                 10-yr 
                 20-yr 
                 10-yr 
                 20-yr 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 RB-1 
                 KM based p-value 
                 0.08 
                 0.03 
                 0.49 
                 0.4 
               
               
                   
                 HR based p-value 
                 0.03 
                 0.03 
                 0.41 
                 0.41 
               
               
                 Proliferation Score 
                 KM based p-value 
                 0.02 
                 0.06 
                 0.17 
                 0.6 
               
               
                   
                 HR based p-value 
                 0.06 
                 0.06 
                 0.24 
                 0.24 
               
               
                 ROR-C 
                 KM based p-value 
                 0.01 
                 0.35 
                 &lt;0.0001 
                 0.06 
               
               
                   
                 HR based p-value 
                 0.21 
                 0.2 
                 0.02 
                 0.02 
               
               
                 ROR-PC 
                 KM based p-value 
                 0.02 
                 0.11 
                 0.09 
                 0.36 
               
               
                   
                 HR based p-value 
                 0.1 
                 0.09 
                 0.04 
                 0.06 
               
               
                   
               
               
                 KM = Kaplan-Meier. 
               
               
                 HR = Hazard Ratio. 
               
            
           
         
       
     
     CONCLUSION 
     RB1, proliferation score and risk of recurrence signatures predict LRR and BCSS benefit for adjuvant radiation therapy in this study. The clinical utility of these biomarkers as predictors for adjuvant radiation therapy requires confirmation in a second independent trial.