Patent Publication Number: US-11643654-B2

Title: Crispr DNA targeting enzymes and systems

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application is a continuation of U.S. Ser. No. 17/506,627, filed Oct. 20, 2021, now granted as U.S. Pat. No. 11,447,771, which is a continuation of U.S. Ser. No. 17/260,791, filed Jan. 15, 2021, now published, which is a U.S. National Stage Application under 35 U.S.C. § 371 of International Application No. PCT/US2018/068007, filed Dec. 28, 2018, which claims priority to U.S. Ser. No. 62/698,842, filed Jul. 16, 2018, and U.S. Ser. No. 62/699,513, filed Jul. 17, 2018. 
    
    
     SEQUENCE LISTING 
     The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on May 26, 2022, is named A2186-701421FT_SL.txt and is 1,380,262 bytes in size. 
     FIELD OF THE INVENTION 
     The present disclosure relates to novel CRISPR-Cas systems and components, systems for detecting CRISPR-Cas systems, and methods and compositions for use of the CRISPR systems in, for example, nucleic acid targeting and manipulation. 
     BACKGROUND 
     Recent application of advances in genome sequencing technologies and analysis have yielded significant insights into the genetic underpinning of biological activities in many diverse areas of nature, ranging from prokaryotic biosynthetic pathways to human pathologies. To fully understand and evaluate the vast quantities of information produced by genetic sequencing technologies, equivalent increases in the scale, efficacy, and ease of technologies for genome and epigenome manipulation are needed. These novel genome and epigenome engineering technologies will accelerate the development of novel applications in numerous areas, including biotechnology, agriculture, and human therapeutics. 
     Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and the CRISPR-associated (Cas) genes, collectively known as the CRISPR-Cas or CRISPR/Cas systems, are currently understood to provide immunity to bacteria and archaea against phage infection. The CRISPR-Cas systems of prokaryotic adaptive immunity are an extremely diverse group of proteins effectors, non-coding elements, as well as loci architectures, some examples of which have been engineered and adapted to produce important biotechnologies. 
     The components of the system involved in host defense include one or more effector proteins capable of modifying DNA or RNA and an RNA guide element that is responsible to targeting these protein activities to a specific sequence on the phage DNA or RNA. The RNA guide is composed of a CRISPR RNA (crRNA) and may require an additional trans-activating RNA (tracrRNA) to enable targeted nucleic acid manipulation by the effector protein(s). The crRNA consists of a direct repeat responsible for protein binding to the crRNA and a spacer sequence that is complementary to the desired nucleic acid target sequence. CRISPR-Cas systems can be reprogrammed to target alternative DNA or RNA targets by modifying the spacer sequence of the crRNA. 
     CRISPR-Cas systems can be broadly classified into two classes: Class 1 systems are composed of multiple effector proteins that together form a complex around a crRNA, and Class 2 systems consist of a single effector protein that complexes with the crRNA to target DNA or RNA substrates. The single-subunit effector composition of the Class 2 systems provides a simpler component set for engineering and application translation, and have thus far been an important source of programmable effectors. Thus, the discovery, engineering, and optimization of novel Class 2 systems may lead to widespread and powerful programmable technologies for genome engineering and beyond. 
     The characterization and engineering of Class 2 CRISPR-Cas systems, exemplified by CRISPR-Cas9, have paved the way for a diverse array of biotechnology applications in genome editing and beyond. For example, the effector proteins Cas12a (Cpf1) and Cas13a (C2c2) possess non-target-specific “collateral” single-stranded-nuclease cleavage activities, which may be harnessed to create novel diagnostics, methods, and other applications. Nevertheless, there remains a need for additional programmable effectors and systems for modifying nucleic acids and polynucleotides (i.e., DNA, RNA, or any hybrid, derivative, or modification) beyond the current CRISPR-Cas systems that enable novel applications through their unique properties. 
     SUMMARY 
     The present disclosure provides non-naturally-occurring, engineered systems and compositions for new single-effector Class 2 CRISPR-Cas systems, together with methods for computational identification of new CRISPR-Cas systems from genomic databases, together with the development of the natural loci into engineered systems, and experimental validation and application translation. These new effectors are divergent in sequence to orthologs and homologs of existing Class 2 CRISPR effectors, and also have unique domain organizations. They provide additional features that include, but are not limited to, 1) novel DNA/RNA editing properties and control mechanisms, 2) smaller size for greater versatility in delivery strategies, 3) genotype triggered cellular processes such as cell death, and 4) programmable RNA-guided DNA insertion, excision, and mobilization. Adding the novel DNA-targeting systems described herein to the toolbox of techniques for genome and epigenome manipulation enables broad applications for specific, programmed perturbations. 
     This disclosure relates to new CRISPR-Cas systems including newly discovered enzymes and other components used to create minimal systems that can be used in non-natural environments, e.g., in bacteria other than those in which the system was initially discovered or in mammalian cells. 
     In one aspect, the disclosure provides engineered, non-naturally occurring Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Cas systems of CLUST.018837 including an RNA guide comprising a direct repeat sequence and a spacer sequence capable of hybridizing to a target nucleic acid; and a CRISPR-associated protein, wherein the CRISPR-associated protein comprises or consists of an amino acid sequence that is at least 80% (e.g., 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100%) identical to an amino acid sequence provided in Table 2 (e.g., SEQ ID NOs: 1-26, 48-262); wherein the CRISPR-associated protein is capable of binding to the RNA guide and of targeting the target nucleic acid sequence complementary to the spacer sequence. In some embodiments, the CRISPR-associated protein has a RuvC domain. 
     In some embodiments of any of the systems described herein, the CRISPR associated protein is the CLUST.018837 effector protein NZ_LDOS01000005 (SEQ ID NO: 1), found in  Metallibacterium scheffleri.    
     In certain embodiments of any of the systems described herein, the CRISPR associated protein is the CLUST.018837 effector protein 3300009004 (SEQ ID NO: 9). 
     In some embodiments of any of the systems described herein, the CRISPR associated protein is the CLUST.018837 effector protein APMI01033782 (SEQ ID NO: 26). 
     In embodiments of any of the systems described herein, the CRISPR associated protein is the CLUST.018837 effector protein NZ_LVXZ01000012 (SEQ ID NO: 3), found in  Acidithiobacillus ferrooxidans.    
     In some embodiments of any of the systems described herein, the CRISPR associated protein is the CLUST.018837 effector protein ADIG01000806 (SEQ ID NO: 20). 
     In various embodiments of any of the systems described herein, the spacer sequence of the RNA guide includes or consists of between about 15 to about 24 nucleotides (e.g., 16 to 22 nucleotides). 
     In some embodiments of any of the systems described herein, the RNA guide includes a direct repeat sequence comprising or consisting of a nucleotide sequence provided in Table 3 (e.g., SEQ ID NOs: 27-47, 263-440). 
     In some embodiments of any of the systems provided herein, the target nucleic acid is a DNA. In some embodiments of any of the systems provided herein, the target nucleic acid is a single-stranded DNA. In some embodiments of any of the systems described herein, the target nucleic acid comprises a protospacer adjacent motif (PAM) (e.g., a 5′-TTN-3′ PAM or a 5′-YTN-3′ PAM, wherein N is any nucleobase and Y is cytosine or thymine). 
     In certain embodiments of any of the systems provided herein, the targeting of the target nucleic acid by the CRISPR-associated protein and RNA guide results in a modification (e.g., a single-stranded or a double-stranded cleavage event) in the target nucleic acid. In some embodiments, the modification is a deletion event. In some embodiments, the modification is an insertion event. In some embodiments, the modification results in cell toxicity. 
     In some embodiments, the CRISPR associated protein has non-specific (i.e., “collateral”) nuclease (e.g., DNAse) activity. In certain embodiments of any of the systems provided herein, the system further includes a donor template nucleic acid (e.g., a DNA or a RNA). 
     In certain embodiments of any of the systems provided herein, the system is within a cell (e.g., a eukaryotic cell (e.g., a mammalian cell) or a prokaryotic cell (e.g., a bacterial cell). 
     In some embodiments of any of the systems provided herein, the RNA guide comprises a tracrRNA, a modulator RNA, or both. In some embodiments of any of the systems provided herein, the system further includes a tracrRNA. In some embodiments of any of the systems provided herein, the system further includes a modulator RNA. 
     In another aspect, the disclosure provides methods of targeting and editing a target nucleic acid, wherein the methods include contacting the target nucleic acid with any of the systems described herein. 
     In another aspect, the disclosure provides methods of targeting the insertion of a payload nucleic acid at a site of a target nucleic acid, wherein the methods include contacting the target nucleic acid with any of the systems described herein. 
     In yet another aspect, the disclosure provides methods of targeting the excision of a payload nucleic acid from a site of a target nucleic acid, wherein the methods include contacting the target nucleic acid with any of the systems described herein. 
     In some embodiments of any of the methods described herein, the target nucleic acid is present at a transcriptionally-active site. 
     In another aspect, the disclosure provides methods of non-specifically degrading single-stranded DNA upon recognition of a DNA target nucleic acid, wherein the methods include contacting the target nucleic acid with any of the systems described herein. 
     In another aspect, the disclosure provides an engineered, non-naturally occurring Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Cas system of CLUST.018837 comprising: a CLUST.018837 CRISPR RNA (crRNA) and/or a nucleic acid encoding the crRNA, wherein the crRNA includes or consists of a direct repeat sequence and a spacer sequence capable of hybridizing to a target nucleic acid, wherein the direct repeat sequence comprises 5′-YBVMRAC-3′ (wherein Y is C, T, or U; B is T, U, C, or G; V is G, C, or A; M is A or C; and R is A or G) at the 3′ terminal end; and a CLUST.018837 CRISPR-Cas effector protein and/or a nucleic acid encoding the effector protein, wherein the effector protein is capable of binding to the crRNA and of targeting the target nucleic acid sequence complementary to the crRNA spacer sequence, wherein the target nucleic acid is a DNA. 
     The term “cleavage event,” as used herein, refers to a DNA break in a target nucleic acid created by a nuclease of a CRISPR-Cas system described herein. In some embodiments, the cleavage event is a double-stranded DNA break. In some embodiments, the cleavage event is a single-stranded DNA break. 
     The term “CRISPR-Cas system” as used herein refers to nucleic acids and/or proteins involved in the expression of, or directing the activity of, CRISPR-Cas effectors, including sequences encoding CRISPR-Cas effectors, RNA guides, and other sequences and transcripts from a CRISPR locus. 
     The term “CRISPR array” as used herein refers to the nucleic acid (e.g., DNA) segment that includes CRISPR repeats and spacers, starting with the first nucleotide of the first CRISPR repeat and ending with the last nucleotide of the last (terminal) CRISPR repeat. Typically, each spacer in a CRISPR array is located between two repeats. The term “CRISPR repeat,” or “CRISPR direct repeat,” or “direct repeat,” as used herein, refers to multiple short direct repeating sequences, which show very little or no sequence variation within a CRISPR array. 
     The term “CRISPR RNA” or “crRNA” as used herein refers to an RNA molecule comprising a guide sequence used by a CRISPR effector to specifically target a nucleic acid sequence. Typically, crRNAs contain a sequence that mediates target recognition and a sequence that forms a duplex with a tracrRNA. The crRNA:tracrRNA duplex binds to a CRISPR effector. The term “donor template nucleic acid,” as used herein refers to a nucleic acid molecule that can be used by one or more cellular proteins to alter the structure of a target nucleic acid after a CRISPR enzyme described herein has altered a target nucleic acid. In some embodiments, the donor template nucleic acid is a double-stranded nucleic acid. In some embodiments, the donor template nucleic acid is a single-stranded nucleic acid. In some embodiments, the donor template nucleic acid is linear. In some embodiments, the donor template nucleic acid is circular (e.g., a plasmid). In some embodiments, the donor template nucleic acid is an exogenous nucleic acid molecule. In some embodiments, the donor template nucleic acid is an endogenous nucleic acid molecule (e.g., a chromosome). 
     The term “CRISPR-Cas effector,” “CRISPR effector,” “effector,” “CRISPR-associated protein,” or “CRISPR enzyme” as used herein refers to a protein that carries out an enzymatic activity or that binds to a target site on a nucleic acid specified by an RNA guide. In some embodiments, a CRISPR effector has endonuclease activity, nickase activity, exonuclease activity, transposase activity, and/or excision activity. 
     The term “RNA guide” as used herein refers to any RNA molecule that facilitates the targeting of a protein described herein to a target nucleic acid. Exemplary “RNA guides” include, but are not limited to, crRNAs, as well as crRNAs fused to either tracrRNAs and/or modulator RNAs. In some embodiments, an RNA guide includes both a crRNA and a tracrRNA. In some embodiments, an RNA guide includes a crRNA and a modulator RNA. In some embodiments, a RNA guide includes a crRNA, a tracrRNA, and a modulator RNA. 
     The term “modulator RNA” as described herein refers to any RNA molecule that modulates (e.g., increases or decreases) an activity of a CRISPR-Cas effector or a nucleoprotein complex that includes a CRISPR-Cas effector. In some embodiments, a modulator RNA modulates a nuclease activity of a CRISPR-Cas effector or a nucleoprotein complex that includes a CRISPR-Cas effector. 
     As used herein, the term “targeting” refers to the ability of a complex including a CRISPR-associated protein and a RNA guide, such as a crRNA, to bind to a specific target nucleic acid and not to other nucleic acids that do not have the same sequence as the target nucleic acid. 
     As used herein, the term “target nucleic acid” refers to a specific nucleic acid sequence that is to be modified by a CRISPR-Cas system described herein. In some embodiments, the target nucleic acid comprises a gene. In some embodiments, the target nucleic acid comprises a non-coding region (e.g., a promoter). In some embodiments, the target nucleic acid is single-stranded. In some embodiments, the target nucleic acid is double-stranded. 
     The terms “trans-activating crRNA” or “tracrRNA” as used herein refer to an RNA including a sequence that forms a structure required for a CRISPR effector to bind to a specified target nucleic acid. 
     A “transcriptionally-active site” as used herein refers to a site in a nucleic acid sequence comprising promoter regions at which transcription is initiated and actively occurring. 
     The term “collateral RNAse activity,” as used herein in reference to a CRISPR enzyme, refers to non-specific RNAse activity of a CRISPR enzyme after the enzyme has modified a specifically targeted nucleic acid. 
     As used herein, the terms “engineered,” “genetically-engineered,” “genetically-modified,” “recombinant,” and “modified,” are used interchangeably and indicate intentional human manipulation to create, or cause a change in, a sequence, combination of sequences, or composition such that the sequence, combination of sequences, or composition does not exist in nature. 
     As used herein the term “operably linked” refers to nucleic acid sequences or amino acid sequences placed into a functional relationship with one another. For instance, a promoter or enhancer is operably linked to a coding sequence if it affects the modulation of the transcription of the coding sequence. Operably linked DNA sequences encoding regulatory sequences are typically contiguous to the coding sequence. However, enhancers can be functional when separated from a promoter, e.g., by up to several kilobases or more. Accordingly, some nucleic acid molecules may be operably linked, but not contiguous. 
     As used herein, the term “subject,” refers to any mammals, including, without limitation, humans and other primates, including rhesus macaques, chimpanzees and other monkey and ape species; farm animals, such as cattle, sheep, pigs, goats, and horses; domestic mammals, such as dogs and cats; laboratory animals, including rabbits, mice, rats, and guinea pigs; as well as birds, including domestic, wild, and game birds, such as chickens, turkeys, ducks, and geese; and the like. The term includes adult, young, and newborn individuals as well as male and female subjects. In some embodiments, a host cell is derived from a subject (e.g., stem cells, progenitor cells, or tissue-specific cells). In some embodiments, the subject is a non-human subject. 
     Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting. 
     Other features and advantages of the invention will be apparent from the following detailed description, and from the claims. 
    
    
     
       BRIEF FIGURE DESCRIPTION 
         FIGS.  1 A and  1 B  are a group of schematic sequence representations that together show conserved. CLUST.018837 effectors and CRISPR array elements for representative loci. 
         FIG.  2 A  is a series of sequences that show the multiple sequence alignment of examples of CRISPR direct repeat elements for CLUST.018837.  FIG.  2 A  discloses SEQ ID NOS 27, 47, 32, 263, 356, 429, 29, 293, 40, 375, 1017, 339, 336, 1018, 332, 317, 329, 1019, 299, 338, 276, 302, 379, 436, 1020-1021, 316, 387, 289, 334, 372, 414, 439, 335, 418, 306, 310, 390, 266, 291 and 1022, respectively, in order of appearance,  FIG.  3 A  discloses SEQ ID NOS 1023-1034 and  FIG.  3 B  discloses SEQ ID NOS 1035-1043, all respectively, in order of appearance. 
         FIG.  2 B  is a weblogo that depicts the 3′ end of a multiple sequence alignment of CLUST.018837 direct repeat sequences. 
         FIGS.  3 A and  3 B  are a group of schematic diagrams that together show predicted secondary structure of the RNA transcript of examples of CLUST.018837 direct repeats.  FIG.  3 A  discloses SEQ ID NOS 1023-1034 and  FIG.  3 B  discloses SEQ ID NOS 1035-1043, all respectively, in order of appearance. 
         FIGS.  4 A,  4 B,  4 C,  4 C,  4 E, and  4 F  are schematic representations that together show a phylogenetic tree of CLUST.018837 effector proteins. 
         FIG.  5 A  shows PFAM domain mapping results for CLUST.018837 effector proteins. 
         FIG.  5 B  is a schematic representation of a multiple sequence alignment of CLUST.018837 effector proteins, with the locations of the conserved catalytic residues of the RuvC domain indicated by the short bars and RuvC-NI/III annotations above the alignment. 
         FIGS.  6 A,  6 B,  6 C, and  6 D  are a series of schematic representations that together show an example of an engineered, non-naturally occurring construct for the CLUST.018837 CRISPR-Cas system containing the NZ_LDOS01000005 effector protein and CRISPR array, both expressed separately from artificial promoters.  FIGS.  6 A,  6 B,  6 C and  6 D  disclose SEQ ID NO: 1044, 
         FIGS.  7 A,  7 B,  7 C,  7 D, and  7 E  are graphs show the degree of depletion activity of the engineered constructs for CRISPR-Cas systems NZ_LDOS01000005, 3300009004, APM101033782, NZ_LVXZ01000012, and ADIG01000806, respectively. 
         FIGS.  8 A,  8 B,  8 C,  8 D, and  8 E  are graphic representations that show the location of strongly depleted targets on the pACYC184 plasmid for the engineered CLUST.018837 CRISPR-Cas systems NZ_LDOS01000005, 3300009004, APM101033782, NZ_LVXZ01000012, and ADIG01000806, respectively. Depleted targets on the top strand and bottom strand are shown separately, and in relation to the orientation of the annotated genes. Depleted targets are depicted by gray bars, with the length of the bar corresponding to the length of the matching spacer, and the shade corresponding to the magnitude of depletion (darker shades corresponding to more depletion). The light gray line indicates the total number of screened spacers targeting each nucleotide position, and the vertical gray lines delineate the boundaries between two features (e.g. tetracycline-resistance gene and the adjacent non-coding region). 
         FIGS.  9 A,  9 B,  9 C,  9 D, and  9 E  are graphic representations that show the locations of strongly depleted targets relative to the targeted  E. coli  essential genes for the engineered CLUST.018837 CRISPR-Cas systems NZ_LDOS01000005, 3300009004, APMI01033782, NZ_LVXZ01000012, and ADIG01000806, respectively. 
         FIGS.  10 A,  10 B,  10 C, and  10 D  are graphic representations that show the locations of strongly depleted targets on the pACYC184 plasmid for the “effector deletion” (negative control) CLUST.018837 CRISPR-Cas constructs for 3300009004, APMI01033782, NZ_LVXZ01000012, and ADIG01000806, respectively. 
         FIGS.  11 A,  11 B,  11 C, and  11 D  are graphic representations that show the locations of strongly depleted targets relative to the targeted  E. coli  essential genes for the “effector deletion” (negative control) CLUST.018837 CRISPR-Cas constructs for 3300009004, APMI01033782, NZ_LVXZ01000012, and ADIG01000806, respectively. 
         FIGS.  12 A,  12 B,  12 C,  12 D, and  12 E  are weblogos of the sequences flanking the sites of strongly depleted targets for the engineered CLUST.018837 CRISPR-Cas systems NZ_LDOS01000005, 3300009004, APM101033782, NZ_LVXZ01000012, and ADIG01000806, respectively. 
         FIGS.  13 A,  13 B, and  13 C  show the mature crRNA (comprising a direct repeat and a spacer) for exemplary CLUST.018837 CRISPR-Cas systems NZ_LDOS01000005, 3300009004, and ADIG01000806, respectively.  FIGS.  13 A,  13 B, and  13 C  also show sequence alignments of RNA-sequenced transcripts including the processed form of the direct repeat and the orientation of the spacer with regard to the direct repeat on the mature crRNA, the processed crRNA sequence, and the secondary structure of a mature crRNA for exemplary CLUST.018837 CRISPR-Cas systems, NZ_LDOS01000005, 3300009004, and ADIG01000806, respectively.  FIG.  13 A  discloses SEQ ID NOS 1045, 1045-1046, 1046, 1046, 1046, 1046, 1046, 1046, 1046, 1046, 1046, 1046, 1046, 1046-1047 and the hairpin sequence as SEQ ID NO: 1048,  FIG.  13 B  discloses SEQ ID NOS 1049, 1049-1050, 1050, 1050, 1050, 1050, 1050, 1050, 1050, 1050, 1050, 1050, 1050, 1050, 1050-1051 and the hairpin sequence as SEQ ID NO: 1052, and  FIG.  13 C  discloses SEQ ID NOS 1053, 1053-1054, 1054, 1054, 1054, 1054, 1054, 1054, 1054, 1054, 1054, 1054, 1054, 1054, 1054, 1054, 1054, 1056 and the hairpin sequence as SEQ ID NO: 1055, all respectively, in order of appearance. 
         FIG.  14    is an image of a gel that shows processing of the pre-crRNA into a mature crRNA by the NZ_LDOS01000005 effector protein in a dose-dependent manner. Pre-crRNA processing in the presence of EDTA suggests that magnesium is not required. 
     
    
    
     DETAILED DESCRIPTION 
     The broad natural diversity of CRISPR-Cas defense systems contains a wide range of activity mechanisms and functional elements that can be harnessed for programmable biotechnologies. In a natural system, these mechanisms and parameters enable efficient defense against foreign DNA and viruses while providing self vs. non-self discrimination to avoid self-targeting. In an engineered system, the same mechanisms and parameters also provide a diverse toolbox of molecular technologies and define the boundaries of the targeting space. For instance, systems Cas9 and Cas13a have canonical DNA and RNA endonuclease activity and their targeting spaces are defined by the protospacer adjacent motif (PAM) on targeted DNA and protospacer flanking sites (PFS) on targeted RNA, respectively. 
     The methods described herein can be used to discover additional mechanisms and parameters within single subunit Class 2 effector systems that can be more effectively harnessed for programmable biotechnologies. 
     In one aspect, the disclosure relates to the use of computational methods and algorithms to search for and identify novel protein families that exhibit a strong co-occurrence pattern with certain other features within naturally occurring genome sequences. In certain exemplary embodiments, these computational methods are directed to identifying protein families that co-occur in close proximity to CRISPR arrays. However, the methods disclosed herein are useful in identifying proteins that naturally occur within close proximity to other features, both non-coding and protein-coding (for example, CRISPR Cas1 proteins). It should be understood that the methods and calculations described herein may be performed on one or more computing devices. 
     In some embodiments, a set of genomic sequences may be obtained from genomic or metagenomic databases. The databases comprise short reads, or contig level data, or assembled scaffolds, or complete organisms. Likewise, the database may comprise genomic sequence data from prokaryotic organisms, or eukaryotic organisms, or may include data from metagenomic environmental samples. Exemplary database repositories include NCBI RefSeq, NCBI GenBank, NCBI Whole Genome Shotgun (WGS), and JGI Integrated Microbial Genomes (IMG). 
     In some embodiments, a minimum size requirement is imposed to select genome sequence data of a specified minimum length. In certain exemplary embodiments, the minimum contig length may be 100 nucleotides, 500 nt, 1 kb, 1.5 kb, 2 kb, 3 kb, 4 kb, 5 kb, 10 kb, 20 kb, 40 kb, or 50 kb. 
     In some embodiments, known or predicted proteins are extracted from the complete or a selected set of genome sequence data. In some embodiments, known or predicted proteins are taken from extracting coding sequence (CDS) annotations provided by the source database. In some embodiments, predicted proteins are determined by applying a computational method to identify proteins from nucleotide sequences. In some embodiments, the GeneMark Suite is used to predict proteins from genome sequences. In some embodiments, Prodigal is used to predict proteins from genome sequences. In some embodiments, multiple protein prediction algorithms may be used over the same set of sequence data with the resulting set of proteins de-duplicated. 
     In some embodiments, CRISPR arrays are identified from the genome sequence data. In some embodiments, PILER-CR is used to identify CRISPR arrays. In some embodiments, CRISPR Recognition Tool (CRT) is used to identify CRISPR arrays. In some embodiments, CRISPR arrays are identified by a heuristic that identifies nucleotide motifs repeated a minimum number of times (e.g. 2, 3, or 4 times), where the spacing between consecutive occurrences of a repeated motif does not exceed a specified length (e.g. 50, 100, or 150 nucleotides). In some embodiments, multiple CRISPR array identification tools may be used over the same set of sequence data with the resulting set of CRISPR arrays de-duplicated. 
     In some embodiments, proteins in close proximity to CRISPR arrays are identified. In some embodiments, proximity is defined as a nucleotide distance, and may be within 20 kb, 15 kb, or 5 kb. In some embodiments, proximity is defined as the number of open reading frames (ORFs) between a protein and a CRISPR array, and certain exemplary distances may be 10, 5, 4, 3, 2, 1, or 0 ORFs. The proteins identified as being within close proximity to a CRISPR array are then grouped into clusters of homologous proteins. In some embodiments, blastclust is used to form protein clusters. In certain other embodiments, mmseqs2 is used to form protein clusters. 
     To establish a pattern of strong co-occurrence between the members of a protein cluster with CRISPR arrays, a BLAST search of each member of the protein family may be performed over the complete set of known and predicted proteins previously compiled. In some embodiments, UBLAST or mmseqs2 may be used to search for similar proteins. In some embodiments, a search may be performed only for a representative subset of proteins in the family. 
     In some embodiments, the clusters of proteins within close proximity to CRISPR arrays are ranked or filtered by a metric to determine co-occurrence. One exemplary metric is the ratio of the number of elements in a protein cluster against the number of BLAST matches up to a certain E value threshold. In some embodiments, a constant E value threshold may be used. In other embodiments, the E value threshold may be determined by the most distant members of the protein cluster. In some embodiments, the global set of proteins is clustered and the co-occurrence metric is the ratio of the number of elements of the CRISPR associated cluster against the number of elements of the containing global cluster(s). 
     In some embodiments, a manual review process is used to evaluate the potential functionality and the minimal set of components of an engineered system based on the naturally occurring locus structure of the proteins in the cluster. In some embodiments, a graphical representation of the protein cluster may assist in the manual review, and may contain information including pairwise sequence similarity, phylogenetic tree, source organisms/environments, predicted functional domains, and a graphical depiction of locus structures. In some embodiments, the graphical depiction of locus structures may filter for nearby protein families that have a high representation. In some embodiments, representation may be calculated by the ratio of the number of related nearby proteins against the size(s) of the containing global cluster(s). In certain exemplary embodiments, the graphical representation of the protein cluster may contain a depiction of the CRISPR array structures of the naturally occurring loci. In some embodiments, the graphical representation of the protein cluster may contain a depiction of the number of conserved direct repeats versus the length of the putative CRISPR array, or the number of unique spacer sequences versus the length of the putative CRISPR array. In some embodiments, the graphical representation of the protein cluster may contain a depiction of various metrics of co-occurrence of the putative effector with CRISPR arrays predict new CRISPR-Cas systems and identify their components. 
     Pooled-Screening 
     To efficiently validate the activity of the engineered novel CRISPR-Cas systems and simultaneously evaluate in an unbiased manner different activity mechanisms and functional parameters, we used a new pooled-screening approach in  E. coli . First, from the computational identification of the conserved protein and noncoding elements of the novel CRISPR-Cas system, DNA synthesis and molecular cloning was used to assemble the separate components into a single artificial expression vector, which in one embodiment is based on a pET-28a+ backbone. In a second embodiment, the effectors and noncoding elements are transcribed on a single mRNA transcript, and different ribosomal binding sites are used to translate individual effectors. 
     Second, the natural crRNA and targeting spacers were replaced with a library of unprocessed crRNAs containing non-natural spacers targeting the essential genes of the host  E. coli , or a second plasmid encoding antibiotic resistance genes, pACYC184. This crRNA library was cloned into the vector backbone containing the protein effectors and noncoding elements (e.g. pET-28a+), and then subsequently transformed the library into  E. coli  along with the pACYC184 plasmid target. Consequently, each resulting  E. coli  cell contains no more than one targeting spacer. In an alternate embodiment, the library of unprocessed crRNAs containing non-natural spacers additionally target  E. coli  essential genes, drawn from resources such as those described in Baba et al. (2006)  Mol. Syst. Biol.  2: 2006.0008 and Gerdes et al. (2003)  J. Bacteriol.  185(19): 5673-84, each of which is incorporated herein by reference in its entirety. In this embodiment, positive, targeted activity of the novel CRISPR-Cas systems that disrupts essential gene function results in cell death or growth arrest. In some embodiments, the essential gene targeting spacers can be combined with the pACYC184 targets to add another dimension to the assay. 
     Third, the  E. coli  were grown under antibiotic selection. In one embodiment, triple antibiotic selection is used: kanamycin for ensuring successful transformation of the pET-28a+ vector containing the engineered CRISPR-Cas effector system, and chloramphenicol and tetracycline for ensuring successful co-transformation of the pACYC184 target vector. Since pACYC184 normally confers resistance to chloramphenicol and tetracycline, under antibiotic selection, positive activity of the novel CRISPR-Cas system targeting the plasmid will eliminate cells that actively express the effectors, noncoding elements, and specific active elements of the crRNA library. Examining the population of surviving cells at a later time point compared to an earlier time point results in a depleted signal compared to the inactive crRNAs. In some embodiments, double antibiotic selection is used. For example, withdrawal of either chloramphenicol or tetracycline to remove selective pressure can provide novel information about the targeting substrate, sequence specificity, and potency. In some embodiments, only kanamycin is used to ensure successful transformation of the pET-28a+ vector containing the engineered CRISPR-Cas effector system. This embodiment is suitable for libraries containing spacers targeting  E. coli  essential genes, as no additional selection beyond kanamycin is needed to observe growth alterations. In this embodiment, chloramphenicol and tetracycline dependence is removed, and their targets (if any) in the library provides an additional source of negative or positive information about the targeting substrate, sequence specificity, and potency. 
     Since the pACYC184 plasmid contains a diverse set of features and sequences that may affect the activity of a CRISPR-Cas system, mapping the active crRNAs from the pooled screen onto pACYC184 provides patterns of activity that can be suggestive of different activity mechanisms and functional parameters in a broad, hypothesis-agnostic manner. In this way, the features required for reconstituting the novel CRISPR-Cas system in a heterologous prokaryotic species can be more comprehensively tested and studied. 
     The key advantages of the in vivo pooled-screen described herein include: 
     (1) Versatility—Plasmid design allows multiple effectors and/or noncoding elements to be expressed; library cloning strategy enables both transcriptional directions of the computationally predicted crRNA to be expressed; 
     (2) Comprehensive tests of activity mechanisms and functional parameters—Evaluates diverse interference mechanisms, including DNA or RNA cleavage; examines co-occurrence of features such as transcription, plasmid DNA replication; and flanking sequences for crRNA library can be used to reliably determine PAMs with complexity equivalence of 4N&#39;s; 
     (3) Sensitivity—by targeting either the pACYC184 plasmid, which has a low copy number, or the single copy of the  E. coli  genome, this screen design enables high sensitivity for CRISPR-Cas activity since even modest interference rates can result in loss of cell viability through loss of antibiotic resistance or essential gene function; and 
     (4) Efficiency—Optimized molecular biology steps to enable greater speed and throughput, because RNA-sequencing and protein expression samples can be directly harvested from the surviving cells in the screen. 
     The novel CRISPR-Cas families described herein were evaluated using this in vivo pooled-screen to evaluate their operational elements, mechanisms and parameters, as well as their ability to be active and reprogrammed in an engineered system outside of their natural cellular environment. 
     Class 2 CRISPR-Cas Effectors Having a RuvC Domain 
     In one aspect, the disclosure provides Class 2 CRISPR-Cas systems referred to herein as CLUST.018837. These Class 2 CRISPR-Cas systems contain an isolated CRISPR-associated protein having a RuvC domain. 
     In some embodiments, the CRISPR-associated protein and the RNA guide form a “binary” complex that may include other components. The binary complex is activated upon binding to a nucleic acid substrate that is complementary to a spacer sequence in the RNA guide (i.e., a sequence-specific substrate or target nucleic acid). In some embodiments, the sequence-specific substrate is a double-stranded DNA. In some embodiments, the sequence-specific substrate is a single-stranded DNA. In some embodiments, the sequence-specific substrate is a single-stranded RNA. In some embodiments, the sequence-specific substrate is a double-stranded RNA. In some embodiments, the sequence-specificity requires a complete match of the spacer sequence in the RNA guide (e.g., crRNA) to the target substrate. In other embodiments, the sequence specificity requires a partial (contiguous or non-contiguous) match of the spacer sequence in the RNA guide (e.g., crRNA) to the target substrate. 
     In some embodiments, the binary complex becomes activated upon binding to the target substrate. In some embodiments, the activated complex exhibits “multiple turnover” activity, whereby upon acting on (e.g., cleaving) the target substrate the activated complex remains in an activated state. In some embodiments, the activated binary complex exhibits “single turnover” activity, whereby upon acting on the target substrate the binary complex reverts to an inactive state. In some embodiments, the activated binary complex exhibits non-specific (i.e., “collateral”) cleavage activity whereby the complex cleaves non-target nucleic acids. In some embodiments, the non-target nucleic acid is a DNA (e.g., a single-stranded or a double-stranded DNA). In some embodiments, the non-target nucleic acid is a RNA (e.g., a single-stranded or a double-stranded RNA). 
     CRISPR Enzyme Modifications 
     Deactivated/Inactivated/Nuclease dead CRISPR Enzymes 
     Where the CRISPR enzymes described herein have nuclease activity, the CRISPR enzymes can be modified to have diminished nuclease activity, e.g., nuclease inactivation of at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95%, at least 97%, or 100% as compared with the wild type CRISPR enzymes. The nuclease activity can be diminished by several methods known in the art, e.g., introducing mutations into the nuclease domains of the proteins. In some embodiments, catalytic residues for the nuclease activities are identified, and these amino acid residues can be substituted by different amino acid residues (e.g., glycine or alanine) to diminish the nuclease activity. 
     Generation of Fusion Proteins 
     Additionally, nuclease dead CRISPR enzymes, whether in their native form or with mutations to modulate their nuclease activity, can provide a foundation from which fusion proteins with additional functional proteins can be created. The nuclease dead CRISPR enzymes can comprise or be associated (e.g., via fusion protein, linker peptides, and “GS” linkers (“GS” disclosed as SEQ ID NO: 1005)) with one or more functional domains. These functional domains can have various activities, e.g., methylase activity, demethylase activity, transcription activation activity, transcription repression activity, transcription release factor activity, histone modification activity, RNA cleavage activity, DNA cleavage activity, nucleic acid binding activity, and switch activity (e.g., light inducible). In some embodiments, the functional domains are Krüppel associated box (KRAB), VP64, VP16, FokI, P65, HSF1, MyoD1, and biotin-APEX. 
     The positioning of the one or more functional domains on the nuclease dead CRISPR enzymes is one that allows for correct spatial orientation for the functional domain to affect the target with the attributed functional effect. For example, if the functional domain is a transcription activator (e.g., VP16, VP64, or p65), the transcription activator is placed in a spatial orientation that allows it to affect the transcription of the target. Likewise, a transcription repressor is positioned to affect the transcription of the target, and a nuclease (e.g., FokI) is positioned to cleave or partially cleave the target. In some embodiments, the functional domain is positioned at the N-terminus of the CRISPR enzyme. In some embodiments, the functional domain is positioned at the C-terminus of the CRISPR enzyme. In some embodiments, the inactivated CRISPR enzyme is modified to comprise a first functional domain at the N-terminus and a second functional domain at the C-terminus. 
     The addition of functional domains to the CRISPR enzymes or onto other effector proteins in the complex may provide an ability for the CRISPR-Cas system to modify the physical DNA (e.g., methylation, etc.) or its regulation (e.g., transcriptional or repression) in situ. 
     Split Enzymes 
     The present disclosure also provides a split version of the CRISPR enzymes described herein. The split version of the CRISPR enzymes may be advantageous for delivery. In some embodiments, the CRISPR enzymes are split to two parts of the enzymes, which together substantially comprises a functioning CRISPR enzyme. 
     The split can be done in a way that the catalytic domain(s) are unaffected. The CRISPR enzymes may function as a nuclease or may be inactivated enzymes, which are essentially RNA-binding proteins with very little or no catalytic activity (e.g., due to mutation(s) in its catalytic domains). 
     In some embodiments, the nuclease lobe and α-helical lobe are expressed as separate polypeptides. Although the lobes do not interact on their own, the RNA guide recruits them into a ternary complex that recapitulates the activity of full-length CRISPR enzymes and catalyzes site-specific DNA cleavage. The use of a modified RNA guide abrogates split-enzyme activity by preventing dimerization, allowing for the development of an inducible dimerization system. The split enzyme is described, e.g., in Wright, Addison V., et al. “Rational design of a split-Cas9 enzyme complex,” Proc. Nat&#39;l. Acad. Sci., 112.10 (2015): 2984-2989, which is incorporated herein by reference in its entirety. 
     In some embodiments, the split enzyme can be fused to a dimerization partner, e.g., by employing rapamycin sensitive dimerization domains. This allows the generation of a chemically inducible CRISPR enzyme for temporal control of CRISPR enzyme activity. The CRISPR enzymes can thus be rendered chemically inducible by being split into two fragments and rapamycin-sensitive dimerization domains can be used for controlled reassembly of the CRISPR enzymes. 
     The split point is typically designed in silico and cloned into the constructs. During this process, mutations can be introduced to the split enzyme and non-functional domains can be removed. In some embodiments, the two parts or fragments of the split CRISPR enzyme (i.e., the N-terminal and C-terminal fragments), can form a full CRISPR enzyme, comprising, e.g., at least 70%, at least 80%, at least 90%, at least 95%, or at least 99% of the sequence of the wild-type CRISPR enzyme. 
     Self-Activating or Inactivating Enzymes 
     The CRISPR enzymes described herein can be designed to be self-activating or self-inactivating. In some embodiments, the CRISPR enzymes are self-inactivating. For example, the target sequence can be introduced into the CRISPR enzyme coding constructs. Thus, the CRISPR enzymes can modify, e.g., cleave, the target sequence, as well as the construct encoding the enzyme thereby self-inactivating their expression. Methods of constructing a self-inactivating CRISPR-Cas system is described, e.g., in Epstein, Benjamin E., and David V. Schaffer. “Engineering a Self-Inactivating CRISPR-Cas System for AAV Vectors,” Mol. Ther., 24 (2016): S50, which is incorporated herein by reference in its entirety. 
     In some other embodiments, an additional RNA guide, expressed under the control of a weak promoter (e.g., 7SK promoter), can target the nucleic acid sequence encoding the CRISPR enzyme to prevent and/or block its expression (e.g., by preventing the transcription and/or translation of the nucleic acid). The transfection of cells with vectors expressing the CRISPR enzyme, and RNA guides that target the nucleic acid encoding the CRISPR enzyme can lead to efficient disruption of the nucleic acid encoding the CRISPR enzyme and decrease the levels of CRISPR enzyme, thereby limiting the genome editing activity. 
     In some embodiments, the genome editing activity of the CRISPR enzymes can be modulated through endogenous RNA signatures (e.g., miRNA) in mammalian cells. The CRISPR enzyme switch can be made by using a miRNA-complementary sequence in the 5′-UTR of mRNA encoding the CRISPR enzyme. The switches selectively and efficiently respond to miRNA in the target cells. Thus, the switches can differentially control the genome editing by sensing endogenous miRNA activities within a heterogeneous cell population. Therefore, the switch systems can provide a framework for cell-type selective genome editing and cell engineering based on intracellular miRNA information (Hirosawa, Moe et al. “Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch,” Nucl. Acids Res., 2017 Jul. 27; 45(13): e118). 
     Inducible CRISPR Enzymes 
     The CRISPR enzymes can be inducible, e.g., light inducible or chemically inducible. This mechanism allows for activation of the functional domain in the CRISPR enzymes. Light inducibility can be achieved by various methods known in the art, e.g., by designing a fusion complex wherein CRY2 PHR/CIBN pairing is used in split CRISPR Enzymes (see, e.g., Konermann et al. “Optical control of mammalian endogenous transcription and epigenetic states,”  Nature,  500.7463 (2013): 472). Chemical inducibility can be achieved, e.g., by designing a fusion complex wherein FKBP/FRB (FK506 binding protein/FKBP rapamycin binding domain) pairing is used in split CRISPR Enzymes. Rapamycin is required for forming the fusion complex, thereby activating the CRISPR enzymes (see, e.g., Zetsche, Volz, and Zhang, “A split-Cas9 architecture for inducible genome editing and transcription modulation,”  Nature Biotech.,  33.2 (2015): 139-142). 
     Furthermore, expression of the CRISPR enzymes can be modulated by inducible promoters, e.g., tetracycline or doxycycline controlled transcriptional activation (Tet-On and Tet-Off expression system), hormone inducible gene expression system (e.g., an ecdysone inducible gene expression system), and an arabinose-inducible gene expression system. When delivered as RNA, expression of the RNA targeting effector protein can be modulated via a riboswitch, which can sense a small molecule like tetracycline (see, e.g., Goldfless, Stephen J. et al. “Direct and specific chemical control of eukaryotic translation with a synthetic RNA-protein interaction,”  Nucl. Acids Res.,  40.9 (2012): e64-e64). 
     Various embodiments of inducible CRISPR enzymes and inducible CRISPR-Cas systems are described, e.g., in U.S. Pat. No. 8,871,445, US20160208243, and WO2016205764, each of which is incorporated herein by reference in its entirety. 
     Functional Mutations 
     Various mutations or modifications can be introduced into CRISPR enzymes as described herein to improve specificity and/or robustness. In some embodiments, the amino acid residues that recognize the Protospacer Adjacent Motif (PAM) are identified. The CRISPR enzymes described herein can be modified further to recognize different PAMs, e.g., by substituting the amino acid residues that recognize PAM with other amino acid residues. In some embodiments, the CRISPR enzymes can recognize a PAM, e.g., 5′-TTN-3′ or 5′-YTN-3′, wherein N is any nucleobase and Y is cytosine or thymine. 
     In some embodiments, at least one Nuclear Localization Signal (NLS) is attached to the nucleic acid sequences encoding the CRISPR enzyme. In some embodiments, at least one Nuclear Export Signal (NES) is attached to the nucleic acid sequences encoding the CRISPR enzyme. In a preferred embodiment a C-terminal and/or N-terminal NLS or NES is attached for optimal expression and nuclear targeting in eukaryotic cells, e.g., human cells. 
     In some embodiments, the CRISPR enzymes described herein are mutated at one or more amino acid residues to alter one or more functional activities. For example, in some embodiments, the CRISPR enzyme is mutated at one or more amino acid residues to alter its helicase activity. In some embodiments, the CRISPR enzyme is mutated at one or more amino acid residues to alter its nuclease activity (e.g., endonuclease activity or exonuclease activity). In some embodiments, the CRISPR enzyme is mutated at one or more amino acid residues to alter its ability to functionally associate with a RNA guide. In some embodiments, the CRISPR enzyme is mutated at one or more amino acid residues to alter its ability to functionally associate with a target nucleic acid. 
     In some embodiments, the CRISPR enzymes described herein are capable of binding to or modifying a target nucleic acid molecule. In some embodiments, the CRISPR enzyme modifies both strands of the target nucleic acid molecule. However, in some embodiments, the CRISPR enzyme is mutated at one or more amino acid residues to alter its nucleic acid manipulation activity. For example, in some embodiments, the CRISPR enzyme may comprise one or more mutations which render the enzyme incapable of cleaving a target nucleic acid. In other embodiments, the CRISPR enzyme may comprise one or more mutations such that the enzyme is capable of cleaving a single strand of the target nucleic acid (i.e., nickase activity). In some embodiments, the CRISPR enzyme is capable of cleaving the strand of the target nucleic acid that is complementary to the strand to which the RNA guide hybridizes. In some embodiments, the CRISPR enzyme is capable of cleaving the strand of the target nucleic acid to which the RNA guide hybridizes. 
     In some embodiments, a CRISPR enzyme described herein may be engineered to comprise a deletion in one or more amino acid residues to reduce the size of the enzyme while retaining one or more desired functional activities (e.g., nuclease activity and the ability to interact functionally with a RNA guide). The truncated CRISPR enzyme may be advantageously used in combination with delivery systems having load limitations. 
     Nucleic Acids Encoding the CRISPR-Associated Proteins Nucleic acids encoding the proteins (e.g., a CRISPR-associated protein) and RNA guides (e.g., a crRNA) described herein are also provided. In some embodiments, the nucleic acid is a synthetic nucleic acid. In some embodiments, the nucleic acid is a DNA molecule. In some embodiments, the nucleic acid is an RNA molecule (e.g., an mRNA molecule). In some embodiments, the nucleic acid is an mRNA. In some embodiments, the mRNA is capped, polyadenylated, substituted with 5-methylcytidine, substituted with pseudouridine, or a combination thereof. In some embodiments, the nucleic acid (e.g., DNA) is operably-linked to a regulatory element (e.g., a promoter) to control the expression of the nucleic acid. In some embodiments, the promoter is a constitutive promoter. In some embodiments, the promoter is an inducible promoter. In some embodiments, the promoter is a cell-specific promoter. In some embodiments, the promoter is an organism-specific promoter. Suitable promoters are known in the art and include, for example, a pol I promoter, a pol II promoter, a pol III promoter, a T7 promoter, a U6 promoter, a H1 promoter, retroviral Rous sarcoma virus LTR promoter, a cytomegalovirus (CMV) promoter, a SV40 promoter, a dihydrofolate reductase promoter, and a O-actin promoter. For example, a U6 promoter can be used to regulate the expression of an RNA guide molecule described herein. 
     In some embodiments, the nucleic acids are modified, e.g., optimized, e.g., codon-optimized, for expression in a eukaryotic cell, e.g., a mammalian cell, such as a human cell. 
     In some embodiments, the nucleic acid(s) are present in a vector (e.g., a viral vector or a phage). The vectors can include one or more regulatory elements that allow for the propagation of the vector in a cell of interest (e.g., a bacterial cell or a mammalian cell). In some embodiments, the vector includes a nucleic acid encoding a single component of a CRISPR-associated (Cas) system described herein. In some embodiments, the vector includes multiple nucleic acids, each encoding a component of a CRISPR-associated (Cas) system described herein. 
     In one aspect, the present disclosure provides nucleic acid sequences that are at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to the nucleic sequences described herein. In another aspect, the present disclosure also provides amino acid sequences that are at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to the amino acid sequences described herein. 
     In some embodiments, the nucleic acid sequences have at least a portion (e.g., at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 30, 40, 50, 60, 70, 80, 90, or 100 nucleotides, e.g., contiguous or non-contiguous nucleotides) that are the same as the sequences described herein. 
     In some embodiments, the nucleic acid sequences have at least a portion (e.g., at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 30, 40, 50, 60, 70, 80, 90, or 100 nucleotides, e.g., contiguous or non-contiguous nucleotides) that is different from the sequences described herein. 
     In some embodiments, the amino acid sequences have at least a portion (e.g., at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 30, 40, 50, 60, 70, 80, 90, or 100 amino acid residues, e.g., contiguous or non-contiguous amino acid residues) that is the same as the sequences described herein. In some embodiments, the amino acid sequences have at least a portion (e.g., at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 30, 40, 50, 60, 70, 80, 90, or 100 amino acid residues, e.g., contiguous or non-contiguous amino acid residues) that is different from the sequences described herein. 
     To determine the percent identity of two amino acid sequences, or of two nucleic acid sequences, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). In general, the length of a reference sequence aligned for comparison purposes should be at least 80% of the length of the reference sequence, and in some embodiments is at least 90%, 95%, or 100% of the length of the reference sequence. The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences. For purposes of the present disclosure, the comparison of sequences and determination of percent identity between two sequences can be accomplished using a Blosum 62 scoring matrix with a gap penalty of 12, a gap extend penalty of 4, and a frameshift gap penalty of 5. 
     RNA Guide Modifications 
     Spacer Lengths 
     The spacer length of RNA guides can range from about 15 to 50 nucleotides. In some embodiments, the spacer length of a RNA guide is at least 16 nucleotides, at least 17 nucleotides, at least 18 nucleotides, at least 19 nucleotides, at least 20 nucleotides, at least 21 nucleotides, or at least 22 nucleotides. In some embodiments, the spacer length is from 15 to 17 nucleotides, from 15 to 23 nucleotides, from 16 to 22 nucleotides, from 17 to 20 nucleotides, from 20 to 24 nucleotides (e.g., 20, 21, 22, 23, or 24 nucleotides), from 23 to 25 nucleotides (e.g., 23, 24, or 25 nucleotides), from 24 to 27 nucleotides, from 27 to 30 nucleotides, from 30 to 45 nucleotides (e.g., 30, 31, 32, 33, 34, 35, 40, or 45 nucleotides), from 30 or 35 to 40 nucleotides, from 41 to 45 nucleotides, from 45 to 50 nucleotides, or longer. In some embodiments, the direct repeat length of the RNA guide is at least 16 nucleotides, or is from 16 to 20 nucleotides (e.g., 16, 17, 18, 19, or 20 nucleotides). In some embodiments, the direct repeat length of the RNA guide is 19 nucleotides. 
     Exemplary RNA guide direct repeat sequences and effector protein pairs are provided in Table 3. In some embodiments, the RNA guide includes a direct repeat sequence comprising or consisting of a nucleic acid sequence listed in Table 3 (e.g., SEQ ID Nos: 27-47, 263-440). 
     The RNA guide sequences can be modified in a manner that allows for formation of the CRISPR complex and successful binding to the target, while at the same time not allowing for successful effector activity (i.e., without nuclease activity/without causing indels). These modified guide sequences are referred to as “dead guides” or “dead guide sequences.” These dead guides or dead guide sequences may be catalytically inactive or conformationally inactive with regard to nuclease activity. Dead guide sequences are typically shorter than respective guide sequences that result in active DNA modification. In some embodiments, dead guides are 5%, 10%, 20%, 30%, 40%, or 50%, shorter than respective RNA guides that have nuclease activity. Dead guide sequences of RNA guides can be from 13 to 15 nucleotides in length (e.g., 13, 14, or 15 nucleotides in length), from 15 to 19 nucleotides in length, or from 17 to 18 nucleotides in length (e.g., 17 nucleotides in length). 
     Thus, in one aspect, the disclosure provides non-naturally occurring or engineered CRISPR-Cas systems including a functional CRISPR enzyme as described herein, and a RNA guide wherein the RNA guide includes a dead guide sequence whereby the RNA guide is capable of hybridizing to a target sequence such that the CRISPR-Cas system is directed to a genomic locus of interest in a cell without detectable nucleic acid modification activity. 
     A detailed description of dead guides is described, e.g., in WO 2016094872, which is incorporated herein by reference in its entirety. 
     Inducible Guides 
     RNA guides can be generated as components of inducible systems. The inducible nature of the systems allows for spatiotemporal control of gene editing or gene expression. In some embodiments, the stimuli for the inducible systems include, e.g., electromagnetic radiation, sound energy, chemical energy, and/or thermal energy. 
     In some embodiments, the transcription of RNA guides can be modulated by inducible promoters, e.g., tetracycline or doxycycline controlled transcriptional activation (Tet-On and Tet-Off expression systems), hormone inducible gene expression systems (e.g., ecdysone inducible gene expression systems), and arabinose-inducible gene expression systems. Other examples of inducible systems include, e.g., small molecule two-hybrid transcription activations systems (FKBP, ABA, etc.), light inducible systems (Phytochrome, LOV domains, or cryptochrome), or Light Inducible Transcriptional Effector (LITE). These inducible systems are described, e.g., in WO 2016205764 and U.S. Pat. No. 8,795,965, both of which are incorporated herein by reference in their entirety. 
     Chemical Modifications 
     Chemical modifications can be applied to the RNA guide&#39;s phosphate backbone, sugar, and/or base. Backbone modifications such as phosphorothioates modify the charge on the phosphate backbone and aid in the delivery and nuclease resistance of the oligonucleotide (see, e.g., Eckstein, “Phosphorothioates, essential components of therapeutic oligonucleotides,”  Nucl. Acid Ther.,  24 (2014), pp. 374-387); modifications of sugars, such as 2′-O-methyl (2′-OMe), 2′-F, and locked nucleic acid (LNA), enhance both base pairing and nuclease resistance (see, e.g., Allerson et al. “Fully 2′-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA,”  J. Med. Chem.,  48.4 (2005): 901-904). Chemically modified bases such as 2-thiouridine or N6-methyladenosine, among others, can allow for either stronger or weaker base pairing (see, e.g., Bramsen et al., “Development of therapeutic-grade small interfering RNAs by chemical engineering,”  Front. Genet.,  2012 Aug. 20; 3:154). Additionally, RNA is amenable to both 5′ and 3′ end conjugations with a variety of functional moieties including fluorescent dyes, polyethylene glycol, or proteins. 
     A wide variety of modifications can be applied to chemically synthesized RNA guide molecules. For example, modifying an oligonucleotide with a 2′-OMe to improve nuclease resistance can change the binding energy of Watson-Crick base pairing. Furthermore, a 2′-OMe modification can affect how the oligonucleotide interacts with transfection reagents, proteins or any other molecules in the cell. The effects of these modifications can be determined by empirical testing. 
     In some embodiments, the RNA guide includes one or more phosphorothioate modifications. In some embodiments, the RNA guide includes one or more locked nucleic acids for the purpose of enhancing base pairing and/or increasing nuclease resistance. 
     A summary of these chemical modifications can be found, e.g., in Kelley et al., “Versatility of chemically synthesized guide RNAs for CRISPR-Cas9 genome editing,”  J . Biotechnol. 2016 Sep. 10; 233:74-83; WO 2016205764; and U.S. Pat. No. 8,795,965 B2; each which is incorporated by reference in its entirety. 
     Sequence Modifications 
     The sequences and the lengths of the RNA guides described herein can be optimized. In some embodiments, the optimized length of RNA guide can be determined by identifying the processed form of tracrRNA and/or crRNA, or by empirical length studies for guide RNAs, tracrRNAs, crRNAs, and the tracrRNA tetraloops. 
     The RNA guides can also include one or more aptamer sequences. Aptamers are oligonucleotide or peptide molecules that can bind to a specific target molecule. The aptamers can be specific to gene effectors, gene activators, or gene repressors. In some embodiments, the aptamers can be specific to a protein, which in turn is specific to and recruits/binds to specific gene effectors, gene activators, or gene repressors. The effectors, activators, or repressors can be present in the form of fusion proteins. In some embodiments, the RNA guide has two or more aptamer sequences that are specific to the same adaptor proteins. In some embodiments, the two or more aptamer sequences are specific to different adaptor proteins. The adaptor proteins can include, e.g., MS2, PP7, Qβ, F2, GA, fr, JP501, M12, R17, BZ13, JP34, JP500, KU1, M11, MX1, TW18, VK, SP, FI, ID2, NL95, TW19, AP205, ϕCb5, ϕCb8r, ϕCb12r, ϕCb23r, 7s, and PRR1. Accordingly, in some embodiments, the aptamer is selected from binding proteins specifically binding any one of the adaptor proteins as described herein. In some embodiments, the aptamer sequence is a MS2 loop. A detailed description of aptamers can be found, e.g., in Nowak et al., “Guide RNA engineering for versatile Cas9 functionality,”  Nucl. Acid. Res.,  2016 Nov. 16; 44(20):9555-9564; and WO 2016205764, which are incorporated herein by reference in their entirety. 
     Guide: Target Sequence Matching Requirements 
     In classic CRISPR-Cas systems, the degree of complementarity between a guide sequence and its corresponding target sequence can be about 50%, 60%, 75%, 80%, 85%, 90%, 95%, 97.5%, 99%, or 100%. In some embodiments, the degree of complementarity is 100%. The RNA guides can be about 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 40, 45, 50, 75, or more nucleotides in length. 
     To reduce off-target interactions, e.g., to reduce the guide interacting with a target sequence having low complementarity, mutations can be introduced to the CRISPR-Cas systems so that the CRISPR-Cas systems can distinguish between target and off-target sequences that have greater than 80%, 85%, 90%, or 95% complementarity. In some embodiments, the degree of complementarity is from 80% to 95%, e.g., about 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, or 95% (for example, distinguishing between a target having 18 nucleotides from an off-target of 18 nucleotides having 1, 2, or 3 mismatches). Accordingly, in some embodiments, the degree of complementarity between a guide sequence and its corresponding target sequence is greater than 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5%, 99%, 99.5%, or 99.9%. In some embodiments, the degree of complementarity is 100%. 
     It is known in the field that complete complementarity is not required provided that there is sufficient complementarity to be functional. For CRISPR nucleases, modulation of cleavage efficiency can be exploited by introduction of mismatches, e.g., one or more mismatches, such as 1 or 2 mismatches between spacer sequence and target sequence, including the position of the mismatch along the spacer/target. The more central (i.e., not at the 3′ or 5′ ends) a mismatch, e.g., a double mismatch, is located; the more cleavage efficiency is affected. Accordingly, by choosing mismatch positions along the spacer sequence, cleavage efficiency can be modulated. For example, if less than 100% cleavage of targets is desired (e.g., in a cell population), 1 or 2 mismatches between spacer and target sequence can be introduced in the spacer sequences. 
     Methods of Using CRISPR-Cas Systems 
     The CRISPR-Cas systems described herein have a wide variety of utilities including modifying (e.g., deleting, inserting, translocating, inactivating, or activating) a target polynucleotide in a multiplicity of cell types. The CRISPR-Cas systems have a broad spectrum of applications in, e.g., DNA/RNA detection (e.g., specific high sensitivity enzymatic reporter unlocking (SHERLOCK)), tracking and labeling of nucleic acids, enrichment assays (extracting desired sequence from background), detecting circulating tumor DNA, preparing next generation library, drug screening, disease diagnosis and prognosis, and treating various genetic diseases or disorders, and treating various non-genetic diseases or disorders, or augmenting health via manipulation of the genome. 
     DNA/RNA Detection 
     In one aspect, the CRISPR-Cas systems described herein can be used in DNA/RNA detection. Single effector RNA-guided DNases can be reprogrammed with CRISPR RNAs (crRNAs) to provide a platform for specific single-stranded DNA (ssDNA) sensing. Upon recognition of its DNA target, activated Type V single effector DNA-guided DNases engage in “collateral” cleavage of nearby non-targeted ssDNAs. This crRNA-programmed collateral cleavage activity allows the CRISPR-Cas systems to detect the presence of a specific DNA by nonspecific degradation of labeled ssDNA. 
     The collateral ssDNA activity can be combined with a reporter in DNA detection applications such as a method called the DNA Endonuclease-Targeted CRISPR trans reporter (DETECTR) method, which achieves attomolar sensitivity for DNA detection (see, e.g., Chen et al., Science, 360(6387):436-439, 2018), which is incorporated herein by reference in its entirety. One application of using the enzymes described herein is to degrade non-specific ssDNA in an in vitro environment. A “reporter” ssDNA molecule linking a fluorophore and a quencher can also be added to the in vitro system, along with an unknown sample of DNA (either single-stranded or double-stranded). Upon recognizing the target sequence in the unknown piece of DNA, the effector complex cleaves the reporter ssDNA resulting in a fluorescent readout. 
     In other embodiments, the SHERLOCK method (Specific High Sensitivity Enzymatic Reporter UnLOCKing) also provides an in vitro nucleic acid detection platform with attomolar (or single-molecule) sensitivity based on nucleic acid amplification and collateral cleavage of a reporter ssDNA, allowing for real-time detection of the target. Methods of using CRISPR in SHERLOCK are described in detail, e.g., in Gootenberg, et al. “Nucleic acid detection with CRISPR-Cas13a/C2c2 ,” Science,  356(6336):438-442 (2017), which is incorporated herein by reference in its entirety. 
     In some embodiments, the CRISPR-Cas systems described herein can be used in multiplexed error-robust fluorescence in situ hybridization (MERFISH). These methods are described in, e.g., Chen et al., “Spatially resolved, highly multiplexed RNA profiling in single cells,”  Science,  2015 Apr. 24; 348(6233):aaa6090, which is incorporated herein by reference in its entirety. 
     Tracking and Labeling of Nucleic Acids 
     Cellular processes depend on a network of molecular interactions among proteins, RNAs, and DNAs. Accurate detection of protein-DNA and protein-RNA interactions is key to understanding such processes. In vitro proximity labeling techniques employ an affinity tag combined with, a reporter group, e.g., a photoactivatable group, to label polypeptides and RNAs in the vicinity of a protein or RNA of interest in vitro. After UV irradiation, the photoactivatable groups react with proteins and other molecules that are in close proximity to the tagged molecules, thereby labelling them. Labelled interacting molecules can subsequently be recovered and identified. The RNA targeting effector proteins can for instance be used to target probes to selected RNA sequences. These applications can also be applied in animal models for in vivo imaging of diseases or difficult-to culture cell types. The methods of tracking and labeling of nucleic acids are described, e.g., in U.S. Pat. No. 8,795,965; WO 2016205764; and WO 2017070605; each of which is incorporated herein by reference in its entirety. 
     High-Throughput Screening 
     The CRISPR-Cas systems described herein can be used for preparing next generation sequencing (NGS) libraries. For example, to create a cost-effective NGS library, the CRISPR-Cas systems can be used to disrupt the coding sequence of a target gene, and the CRISPR enzyme transfected clones can be screened simultaneously by next-generation sequencing (e.g., on an Illumina system). A detailed description regarding how to prepare NGS libraries can be found, e.g., in Bell et al., “A high-throughput screening strategy for detecting CRISPR-Cas9 induced mutations using next-generation sequencing,”  BMC Genomics,  15.1 (2014): 1002, which is incorporated herein by reference in its entirety. 
     Engineered Microorganisms 
     Microorganisms (e.g.,  E. coli , yeast, and microalgae) are widely used for synthetic biology. The development of synthetic biology has a wide utility, including various clinical applications. For example, the programmable CRISPR-Cas systems can be used to split proteins of toxic domains for targeted cell death, e.g., using cancer-linked RNA as target transcript. Further, pathways involving protein-protein interactions can be influenced in synthetic biological systems with e.g. fusion complexes with the appropriate effectors such as kinases or enzymes. 
     In some embodiments, RNA guide sequences that target phage sequences can be introduced into the microorganism. Thus, the disclosure also provides methods of vaccinating a microorganism (e.g., a production strain) against phage infection. 
     In some embodiments, the CRISPR-Cas systems provided herein can be used to engineer microorganisms, e.g., to improve yield or improve fermentation efficiency. For example, the CRISPR-Cas systems described herein can be used to engineer microorganisms, such as yeast, to generate biofuel or biopolymers from fermentable sugars, or to degrade plant-derived lignocellulose derived from agricultural waste as a source of fermentable sugars. More particularly, the methods described herein can be used to modify the expression of endogenous genes required for biofuel production and/or to modify endogenous genes, which may interfere with the biofuel synthesis. These methods of engineering microorganisms are described e.g., in Verwaal et al., “CRISPR/Cpf1 enables fast and simple genome editing of  Saccharomyces cerevisiae,” Yeast,  2017 Sep. 8. doi: 10.1002/yea.3278; and Hlavova et al., “Improving microalgae for biotechnology—from genetics to synthetic biology,”  Biotechnol. Adv.,  2015 Nov. 1; 33:1194-203, both of which are incorporated herein by reference in their entirety. 
     Application in Plants 
     The CRISPR-Cas systems described herein have a wide variety of utility in plants. In some embodiments, the CRISPR-Cas systems can be used to engineer genomes of plants (e.g., improving production, making products with desired post-translational modifications, or introducing genes for producing industrial products). In some embodiments, the CRISPR-Cas systems can be used to introduce a desired trait to a plant (e.g., with or without heritable modifications to the genome), or regulate expression of endogenous genes in plant cells or whole plants. 
     In some embodiments, the CRISPR-Cas systems can be used to identify, edit, and/or silence genes encoding specific proteins, e.g., allergenic proteins (e.g., allergenic proteins in peanuts, soybeans, lentils, peas, green beans, and mung beans). A detailed description regarding how to identify, edit, and/or silence genes encoding proteins is described, e.g., in Nicolaou et al., “Molecular diagnosis of peanut and legume allergy,”  Curr. Opin. Allergy Clin. Immunol.,  11(3):222-8 (2011), and WO 2016205764 A1; both of which are incorporated herein by reference in their entirety. 
     Gene Drives 
     Gene drive is the phenomenon in which the inheritance of a particular gene or set of genes is favorably biased. The CRISPR-Cas systems described herein can be used to build gene drives. For example, the CRISPR-Cas systems can be designed to target and disrupt a particular allele of a gene, causing the cell to copy the second allele to fix the sequence. Because of the copying, the first allele will be converted to the second allele, increasing the chance of the second allele being transmitted to the offspring. A detailed method regarding how to use the CRISPR-Cas systems described herein to build gene drives is described, e.g., in Hammond et al., “A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector  Anopheles gambiae,” Nat. Biotechnol.,  2016 January; 34(1):78-83, which is incorporated herein by reference in its entirety. 
     Pooled-Screening 
     As described herein, pooled CRISPR screening is a powerful tool for identifying genes involved in biological mechanisms such as cell proliferation, drug resistance, and viral infection. Cells are transduced in bulk with a library of RNA guide-encoding vectors described herein, and the distribution of RNA guides is measured before and after applying a selective challenge. Pooled CRISPR screens work well for mechanisms that affect cell survival and proliferation, and they can be extended to measure the activity of individual genes (e.g., by using engineered reporter cell lines). Arrayed CRISPR screens, in which only one gene is targeted at a time, make it possible to use RNA-seq as the readout. In some embodiments, the CRISPR-Cas systems as described herein can be used in single-cell CRISPR screens. A detailed description regarding pooled CRISPR screenings can be found, e.g., in Datlinger et al., “Pooled CRISPR screening with single-cell transcriptome read-out,”  Nat. Methods.,  2017 March; 14(3):297-301, which is incorporated herein by reference in its entirety. 
     Saturation Mutagenesis (“Bashing”) 
     The CRISPR-Cas systems described herein can be used for in situ saturating mutagenesis. In some embodiments, a pooled RNA guide library can be used to perform in situ saturating mutagenesis for particular genes or regulatory elements. Such methods can reveal critical minimal features and discrete vulnerabilities of these genes or regulatory elements (e.g., enhancers). These methods are described, e.g., in Canver et al., “BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis,”  Nature,  2015 Nov. 12; 527(7577):192-7, which is incorporated herein by reference in its entirety. 
     Quantitative Trait Mapping (crisprQTL) 
     The CRISPR-Cas systems described herein can be used for mapping coding and non-coding regions of a genome that influence gene expression. For example, in some embodiments, a population of cells may be transduced with multiple random, barcoded, CRISPR guide RNA-programmed perturbations in each cell. Single-cell RNA-sequencing may then be used to profile gene expression and the collection of RNA guides in each cell. The generated data can then be used to identify associations between RNA guides and quantitative changes in gene expression, which facilitates the analysis of the cis-regulatory architecture of the cells. These methods are described, for example, in Gasperini et al., “crisprQTL mapping as a genome-wide association framework for cellular genetic screens,” bioRxiv 314344, posted May 4, 2018, doi: doi.org/10.1101/314344, which is incorporated herein by reference in its entirety. 
     Therapeutic Applications 
     The CRISPR-Cas systems described herein can have various therapeutic applications. In some embodiments, the new CRISPR-Cas systems can be used to treat various diseases and disorders, e.g., genetic disorders (e.g., monogenetic diseases), diseases that can be treated by nuclease activity (e.g., Pcsk9 targeting, Duchenne Muscular Dystrophy (DMD), BCL11a targeting), and various cancers, etc. 
     In some embodiments, the CRISPR-Cas systems described herein can be used to edit a target nucleic acid to modify the target nucleic acid (e.g., by inserting, deleting, or mutating one or more amino acid residues). For example, in some embodiments the CRISPR-Cas systems described herein comprise an exogenous donor template nucleic acid (e.g., a DNA molecule or an RNA molecule), which comprises a desirable nucleic acid sequence. Upon resolution of a cleavage event induced with the CRISPR-Cas system described herein, the molecular machinery of the cell utilizes the exogenous donor template nucleic acid in repairing and/or resolving the cleavage event. Alternatively, the molecular machinery of the cell can utilize an endogenous template in repairing and/or resolving the cleavage event. In some embodiments, the CRISPR-Cas systems described herein may be used to alter a target nucleic acid resulting in an insertion, a deletion, and/or a point mutation). In some embodiments, the insertion is a scarless insertion (i.e., the insertion of an intended nucleic acid sequence into a target nucleic acid resulting in no additional unintended nucleic acid sequence upon resolution of the cleavage event). Donor template nucleic acids may be double stranded or single stranded nucleic acid molecules (e.g., DNA or RNA). Methods of designing exogenous donor template nucleic acids are described, for example, in PCT Publication No. WO 2016094874 A1, the entire contents of which are expressly incorporated herein by reference. 
     In one aspect, the CRISPR-Cas systems described herein can be used for treating a disease caused by overexpression of RNAs, toxic RNAs, and/or mutated RNAs (e.g., splicing defects or truncations). For example, expression of the toxic RNAs may be associated with the formation of nuclear inclusions and late-onset degenerative changes in brain, heart, or skeletal muscle. In some embodiments, the disorder is myotonic dystrophy. In myotonic dystrophy, the main pathogenic effect of the toxic RNAs is to sequester binding proteins and compromise the regulation of alternative splicing (see, e.g., Osborne et al., “RNA-dominant diseases,”  Hum. Mol. Genet.,  2009 Apr. 15; 18(8):1471-81). Myotonic dystrophy (dystrophia myotonica (DM)) is of particular interest to geneticists because it produces an extremely wide range of clinical features. The classical form of DM, which is now called DM type 1 (DM1), is caused by an expansion of CTG repeats in the 3′-untranslated region (UTR) of DMPK, a gene encoding a cytosolic protein kinase. The CRISPR-Cas systems as described herein can target overexpressed RNA or toxic RNA, e.g., the DMPK gene or any of the mis-regulated alternative splicing in DM1 skeletal muscle, heart, or brain. 
     The CRISPR-Cas systems described herein can also target trans-acting mutations affecting RNA-dependent functions that cause various diseases such as, e.g., Prader Willi syndrome, Spinal muscular atrophy (SMA), and Dyskeratosis congenita. A list of diseases that can be treated using the CRISPR-Cas systems described herein is summarized in Cooper et al., “RNA and disease,”  Cell,  136.4 (2009): 777-793, and WO 2016205764 A1, both of which are incorporated herein by reference in their entirety. Those of skill in this field will understand how to use the new CRISPR-Cas systems to treat these diseases. 
     The CRISPR-Cas systems described herein can also be used in the treatment of various tauopathies, including, e.g., primary and secondary tauopathies, such as primary age-related tauopathy (PART)/Neurofibrillary tangle (NFT)-predominant senile dementia (with NFTs similar to those seen in Alzheimer Disease (AD), but without plaques), dementia pugilistica (chronic traumatic encephalopathy), and progressive supranuclear palsy. A useful list of tauopathies and methods of treating these diseases are described, e.g., in WO 2016205764, which is incorporated herein by reference in its entirety. 
     The CRISPR-Cas systems described herein can also be used to target mutations disrupting the cis-acting splicing codes that can cause splicing defects and diseases. These diseases include, e.g., motor neuron degenerative disease that results from deletion of the SMN1 gene (e.g., spinal muscular atrophy), Duchenne Muscular Dystrophy (DMD), frontotemporal dementia, and Parkinsonism linked to chromosome 17 (FTDP-17), and cystic fibrosis. 
     The CRISPR-Cas systems described herein can further be used for antiviral activity, in particular against RNA viruses. The effector proteins can target the viral RNAs using suitable RNA guides selected to target viral RNA sequences. 
     Furthermore, in vitro RNA sensing assays can be used to detect specific RNA substrates. The RNA targeting effector proteins can be used for RNA-based sensing in living cells. Examples of applications are diagnostics by sensing of, for examples, disease-specific RNAs. 
     A detailed description of therapeutic applications of the CRISPR-Cas systems described herein can be found, e.g., in U.S. Pat. No. 8,795,965, EP 3009511, WO 2016205764, and WO 2017070605; each of which is incorporated herein by reference in its entirety. 
     Delivery of CRISPR-Cas Systems 
     Through this disclosure and the knowledge in the art, the CRISPR-Cas systems described herein, or components thereof, nucleic acid molecules thereof, or nucleic acid molecules encoding or providing components thereof, can be delivered by various delivery systems such as vectors, e.g., plasmids, viral delivery vectors. The new CRISPR enzymes and/or any of the RNAs (e.g., RNA guides) can be delivered using suitable vectors, e.g., plasmids or viral vectors, such as adeno-associated viruses (AAV), lentiviruses, adenoviruses, and other viral vectors, or combinations thereof. The proteins and one or more RNA guides can be packaged into one or more vectors, e.g., plasmids or viral vectors. 
     In some embodiments, the vectors, e.g., plasmids or viral vectors, are delivered to the tissue of interest by, e.g., intramuscular injection, intravenous administration, transdermal administration, intranasal administration, oral administration, or mucosal administration. Such delivery may be either via a single dose or multiple doses. One skilled in the art understands that the actual dosage to be delivered herein may vary greatly depending upon a variety of factors, such as the vector choices, the target cells, organisms, tissues, the general conditions of the subject to be treated, the degrees of transformation/modification sought, the administration routes, the administration modes, the types of transformation/modification sought, etc. 
     In certain embodiments, the delivery is via adenoviruses, which can be at a single dose containing at least 1×10 5  particles (also referred to as particle units, pu) of adenoviruses. In some embodiments, the dose preferably is at least about 1×10 6  particles, at least about 1×10 7  particles, at least about 1×10 8  particles, and at least about 1×10 9  particles of the adenoviruses. The delivery methods and the doses are described, e.g., in WO 2016205764 A1 and U.S. Pat. No. 8,454,972 B2, both of which are incorporated herein by reference in their entirety. 
     In some embodiments, the delivery is via a recombinant adeno-associated virus (rAAV) vector. For example, in some embodiments, a modified AAV vector may be used for delivery. Modified AAV vectors can be based on one or more of several capsid types, including AAV1, AV2, AAV5, AAV6, AAV8, AAV 8.2, AAV9, AAV rhlO, modified AAV vectors (e.g., modified AAV2, modified AAV3, modified AAV6) and pseudotyped AAV (e.g., AAV2/8, AAV2/5 and AAV2/6). Exemplary AAV vectors and techniques that may be used to produce rAAV particles are known in the art (see, e.g., Aponte-Ubillus et al. (2018) Appl. Microbiol. Biotechnol. 102(3): 1045-54; Zhong et al. (2012) J. Genet. Syndr. Gene Ther. Si: 008; West et al. (1987) Virology 160: 38-47 (1987); Tratschin et al. (1985) Mol. Cell. Biol. 5: 3251-60); U.S. Pat. Nos. 4,797,368 and 5,173,414; and International Publication Nos. WO 2015/054653 and WO 93/24641, each of which is incorporated herein by reference in its entirety). 
     In some embodiments, the delivery is via plasmids. The dosage can be a sufficient number of plasmids to elicit a response. In some cases, suitable quantities of plasmid DNA in plasmid compositions can be from about 0.1 to about 2 mg. Plasmids generally include (i) a promoter; (ii) a sequence encoding a nucleic acid-targeting CRISPR enzymes, operably linked to the promoter; (iii) a selectable marker; (iv) an origin of replication; and (v) a transcription terminator downstream of and operably linked to (ii). The plasmids can also encode the RNA components of a CRISPR complex, but one or more of these may instead be encoded on different vectors. The frequency of administration is within the ambit of the medical or veterinary practitioner (e.g., physician, veterinarian), or a person skilled in the art. 
     In another embodiment, the delivery is via liposomes or lipofectin formulations and the like, and can be prepared by methods known to those skilled in the art. Such methods are described, for example, in WO 2016205764 and U.S. Pat. Nos. 5,593,972; 5,589,466; and 5,580,859; each of which is incorporated herein by reference in its entirety. 
     In some embodiments, the delivery is via nanoparticles or exosomes. For example, exosomes have been shown to be particularly useful in delivery RNA. 
     Further means of introducing one or more components of the new CRISPR-Cas systems to the cell is by using cell penetrating peptides (CPP). In some embodiments, a cell penetrating peptide is linked to the CRISPR enzymes. In some embodiments, the CRISPR enzymes and/or RNA guides are coupled to one or more CPPs to transport them inside cells effectively (e.g., plant protoplasts). In some embodiments, the CRISPR enzymes and/or RNA guide(s) are encoded by one or more circular or non-circular DNA molecules that are coupled to one or more CPPs for cell delivery. 
     CPPs are short peptides of fewer than 35 amino acids derived either from proteins or from chimeric sequences capable of transporting biomolecules across cell membrane in a receptor independent manner. CPPs can be cationic peptides, peptides having hydrophobic sequences, amphipathic peptides, peptides having proline-rich and anti-microbial sequences, and chimeric or bipartite peptides. Examples of CPPs include, e.g., Tat (which is a nuclear transcriptional activator protein required for viral replication by HIV type 1), penetratin, Kaposi fibroblast growth factor (FGF) signal peptide sequence, integrin β3 signal peptide sequence, polyarginine peptide Args sequence, Guanine rich-molecular transporters, and sweet arrow peptide. CPPs and methods of using them are described, e.g., in Hillbrink et al., “Prediction of cell-penetrating peptides,”  Methods Mol. Biol.,  2015; 1324:39-58; Ramakrishna et al., “Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA,”  Genome Res.,  2014 June; 24(6):1020-7; and WO 2016205764 A1; each of which is incorporated herein by reference in its entirety. 
     Various delivery methods for the CRISPR-Cas systems described herein are also described, e.g., in U.S. Pat. No. 8,795,965, EP 3009511, WO 2016205764, and WO 2017070605; each of which is incorporated herein by reference in its entirety. 
     EXAMPLES 
     The invention is further described in the following examples, which do not limit the scope of the invention described in the claims. 
     Example 1—Identification of Minimal Components for CLUST.018837 CRISPR-Cas System (FIGS.  1 - 5 ) 
     Genome and metagenome sequences were downloaded from NCBI (Benson et al., 2013; Pruitt et al., 2012), NCBI whole genome sequencing (WGS), and DOE JGI Integrated Microbial Genomes (Markowitz et al., 2012) and processed as described in the Detailed Description of this disclosure. 
     The identified CRISPR-Cas system described herein, designated CLUST.018837, contains a large single effector associated with CRISPR arrays found in  Acidithiobacillus, Clostridiales, Gordonia, Metallibacterium, Mycobacterium, Pelobacter, Rhodanobacter, Thioalkalivibrio , and  Thiobacillus  bacteria, as well as uncultured metagenomic sequences collected from a range of environments, including termite gut, soil, ground water, waste water, marine, and hot springs environments (TABLE 1). CLUST.018837 effectors include the exemplary proteins detailed in TABLES 1 and 2. Exemplary direct repeat sequences for these systems are shown in TABLE 3.
         Examples of naturally occurring loci containing this effector complex are depicted in  FIGS.  1 A-B , indicating that for loci containing the CLUST.018837 CRISPR-Cas system, the effector protein co-occurs with a CRISPR array. No other families of large proteins were identified within a bi-directional 15 kb window that co-occur with the effector protein or CRISPR array.   The direct repeat sequences for CLUST.018837 CRISPR-Cas systems show a consensus 5′-YBVMRAC-3′ (wherein Y is C or T; B is T, C, or G; V is G, C, or A; M is A or C; and R is A or G) nucleotide sequence at the 3′ terminal end ( FIG.  2 B ).   The predicted secondary structure of direct repeat sequences for example CLUST.018837 CRISPR-Cas systems is depicted in  FIGS.  3 A-B , indicating a high prevalence of predicted stem loop structures.     FIGS.  4 A-F , combined, show a phylogenetic tree of CLUST.018837 effectors, showing that the family exhibits sequence diversity and at a top level comprises three sub-families.   An HMM profile search of the multiple sequence alignment of CLUST.018837 effectors against the PFAM database indicates the presence of the OrfB_Zn_ribbon domain ( FIG.  5 A ). Manual inspection of the multiple sequence alignment reveals the locations of the conserved catalytic residues of the RuvC domain, indicated in  FIG.  5 B . Notably, the RuvC I domain does not contain any highly conserviced residues across this family.       

     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Representative CLUST.018837 Effector Proteins 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 effec- 
               
               
                   
                   
                 # 
                   
                   
                 tor 
               
               
                 Species 
                 effector accession 
                 spacers 
                 cas1 
                 cas2 
                 size 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Metallibacterium scheffleri 
                 WP_081130164.1 
                 9 
                 N 
                 N 
                 627 
               
               
                 (NZ_LDOS01000005) 
                   
                   
                   
                   
                   
               
               
                   Thiobacillus denitrificans  DSM 12475 
                 WP_018079340.1 
                 2 
                 N 
                 N 
                 633 
               
               
                 (NZ_AQWL01000014) 
                   
                   
                   
                   
                   
               
               
                 
                   Acidithiobacillus ferrooxidans 
                 
                 WP_064217851.1 
                 5 
                 N 
                 N 
                 596 
               
               
                 (NZ_LVXZ01000012) 
                   
                   
                   
                   
                   
               
               
                 
                   Acidithiobacillus thiooxidans 
                 
                 JMEB01000165_11 
                 2 
                 N 
                 N 
                 593 
               
               
                 (JMEB01000165) 
                   
                   
                   
                   
                   
               
               
                 
                   Acidithiobacillus thiooxidans 
                 
                 WP_051690567.1 
                 2 
                 N 
                 N 
                 615 
               
               
                 (JMEB01000165) 
                   
                   
                   
                   
                   
               
               
                   Rhodanobacter  sp. 67-28 
                 OJW42488.1 
                 3 
                 N 
                 N 
                 617 
               
               
                 (MKTU01000021) 
                   
                   
                   
                   
                   
               
               
                 activated carbon metagenome 
                 LNFM01018448_6 
                 4 
                 N 
                 N 
                 655 
               
               
                 (LNFM01018448) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater 
                 3300004774|Ga0007794_10001723_8 
                 2 
                 N 
                 N 
                 573 
               
               
                 (3300004774|Ga0007794_10001723) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater 
                 3300004776|Ga0007800_10001775_2 
                 2 
                 N 
                 N 
                 573 
               
               
                 (3300004776|Ga0007800_10001775) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-aquifer 
                 3300009004|Ga0100377_1000348_44 
                 2 
                 N 
                 N 
                 614 
               
               
                 (3300009004|Ga0100377_1000348) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater sediment 
                 3300004236|Ga0066449_1000007_83 
                 5 
                 N 
                 N 
                 582 
               
               
                 (3300004236|Ga0066449_1000007) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine 
                 3300009432|Ga0115005_10004282_5 
                 3 
                 N 
                 N 
                 585 
               
               
                 (3300009432|Ga0115005_10004282) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine 
                 3300009436|Ga0115008_10017733_3 
                 3 
                 N 
                 N 
                 587 
               
               
                 (3300009436|Ga0115008_10017733) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine 
                 3300009436|Ga0115008_10017733_4 
                 3 
                 N 
                 N 
                 569 
               
               
                 (3300009436|Ga0115008_10017733) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine-pelagic marine 
                 3300001351|JGI20153J14318_10007490_6 
                 5 
                 N 
                 N 
                 585 
               
               
                 (3300001351|JGI20153/14318_10007490) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine-pelagic marine 
                 3300009447|Ga0115560_1022222_2 
                 2 
                 N 
                 N 
                 585 
               
               
                 (3300009447|Ga0115560_1022222) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine-pelagic marine 
                 3300009505|Ga0115564_10016546_3 
                 4 
                 N 
                 N 
                 586 
               
               
                 (3300009505|Ga0115564_10016546) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine-seawater 
                 3300020165|Ga0206125_10004811_3 
                 4 
                 N 
                 N 
                 592 
               
               
                 (3300020165|Ga0206125_10004811) 
                   
                   
                   
                   
                   
               
               
                 aquatic-thermal springs-hot spring 
                 3300010313|Ga0116211_1004493_2 
                 4 
                 N 
                 N 
                 577 
               
               
                 (3300010313|Ga0116211_1004493) 
                   
                   
                   
                   
                   
               
               
                 arthropoda-digestive system-termite gut 
                 3300009784|Ga0123357_10002363_9 
                 24 
                 N 
                 N 
                 614 
               
               
                 (3300009784|Ga0123357_10002363) 
                   
                   
                   
                   
                   
               
               
                 groundwater metagenome 
                 ADIG01000806_20 
                 5 
                 N 
                 N 
                 631 
               
               
                 (ADIG01000806) 
                   
                   
                   
                   
                   
               
               
                 groundwater metagenome 
                 CXWL01128655_18 
                 3 
                 N 
                 N 
                 575 
               
               
                 (CXWL01128655) 
                   
                   
                   
                   
                   
               
               
                 hot springs metagenome 
                 OGCL01001770_13 
                 5 
                 N 
                 N 
                 577 
               
               
                 (OGCL01001770) 
                   
                   
                   
                   
                   
               
               
                 soil metagenome (LNAP01002847) 
                 LNAP01002847_16 
                 3 
                 N 
                 N 
                 579 
               
               
                 terrestrial-soil-pond soil 
                 3300007533|Ga0102944_1000048_72 
                 4 
                 N 
                 N 
                 621 
               
               
                 (3300007533|Ga0102944_1000048) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-pond soil 
                 3300007533|Ga0102944_1003721_10 
                 6 
                 N 
                 N 
                 632 
               
               
                 (3300007533|Ga0102944_1003721) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-pond soil 
                 3300007533|Ga0102944_1003721_8 
                 6 
                 N 
                 N 
                 621 
               
               
                 (3300007533|Ga0102944_1003721) 
                   
                   
                   
                   
                   
               
               
                 wastewater metagenome 
                 APMI01033782_24 
                 9 
                 N 
                 N 
                 612 
               
               
                 (APMI01033782) 
                   
                   
                   
                   
                   
               
               
                 Clostridiales bacterium DRI-13 
                 NZ_JQKL01000024_23 
                 14 
                 N 
                 N 
                 567 
               
               
                 (NZ_JQKL01000024) 
                   
                   
                   
                   
                   
               
               
                 Clostridiales bacterium DRI-13 
                 WP_081908191.1 
                 14 
                 N 
                 N 
                 594 
               
               
                 (NZ_JQKL01000024) 
                   
                   
                   
                   
                   
               
               
                 Gordonia otitidis NBRC 100426 
                 GAB36148.1 
                 5 
                 N 
                 N 
                 607 
               
               
                 (BAFB01000202) 
                   
                   
                   
                   
                   
               
               
                 Gordonia otitidis NBRC 100426 
                 BAFB01000202_4 
                 5 
                 N 
                 N 
                 591 
               
               
                 (BAFB01000202) 
                   
                   
                   
                   
                   
               
               
                 Gordonia otitidis NBRC 100426 
                 WP_039994403.1 
                 5 
                 N 
                 N 
                 597 
               
               
                 (NZ_BAFB01000202) 
                   
                   
                   
                   
                   
               
               
                 Meiothermus silvanus DSM 9946 
                 WP_013159911.1 
                 3 
                 N 
                 N 
                 536 
               
               
                 (NC_014214) 
                   
                   
                   
                   
                   
               
               
                 Methylomonas koyamae (NZ_CP023670) 
                 WP_096876841.1 
                 4 
                 N 
                 N 
                 589 
               
               
                 Mycobacterium conceptionense 
                 WP_048895525.1 
                 9 
                 N 
                 N 
                 603 
               
               
                 (NZ_LFOD01000003) 
                   
                   
                   
                   
                   
               
               
                 Mycobacterium mucogenicum 
                 WP_061006603.1 
                 14 
                 N 
                 N 
                 596 
               
               
                 (LSKL01000323) 
                   
                   
                   
                   
                   
               
               
                 Pelobacter propionicus DSM 2379 
                 WP_011733919.1 
                 3 
                 N 
                 N 
                 664 
               
               
                 (CP000483) 
                   
                   
                   
                   
                   
               
               
                 Thioalkalivibrio thiocyanodenitrificans 
                 WP_018234394.1 
                 3 
                 N 
                 N 
                 599 
               
               
                 ARhD 1 (NZ_KB900537) 
                   
                   
                   
                   
                   
               
               
                 algae-green algae-macroalgal surface- 
                 3300000944|BBAY81_10000005_89 
                 6 
                 N 
                 N 
                 636 
               
               
                 ecklonia radiata 2 
                   
                   
                   
                   
                   
               
               
                 (3300000944|BBAY81_10000005) 
                   
                   
                   
                   
                   
               
               
                 anaerobic digester metagenome 
                 LSQX01035253_23 
                 5 
                 N 
                 N 
                 592 
               
               
                 (LSQX01035253) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater 
                 3300013131|Ga0172373_10056063_2 
                 2 
                 N 
                 N 
                 696 
               
               
                 (3300013131|Ga0172373_10056063) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater 
                 3300013136|Ga0172370_10027535_4 
                 5 
                 N 
                 N 
                 670 
               
               
                 (3300013136|Ga0172370_10027535) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater 
                 3300013137|Ga0172375_10012175_6 
                 10 
                 N 
                 N 
                 655 
               
               
                 (3300013137|Ga0172375_10012175) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-anoxic lake water 
                 3300010293|Ga0116204_1010874_1 
                 3 
                 N 
                 N 
                 601 
               
               
                 (3300010293|Ga0116204_1010874) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-anoxic lake water 
                 3300010293|Ga0116204_1010874_2 
                 3 
                 N 
                 N 
                 620 
               
               
                 (3300010293|Ga0116204_1010874) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-aquifer 
                 3300008255|Ga0100403_1011992_3 
                 7 
                 N 
                 N 
                 588 
               
               
                 (3300008255|Ga0100403_1011992) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-bog 
                 3300014155|Ga0181524_10003409_23 
                 3 
                 N 
                 N 
                 685 
               
               
                 (3300014155|Ga0181524_10003409) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-bog 
                 3300014156|Ga0181518_10000096_28 
                 12 
                 N 
                 N 
                 685 
               
               
                 (3300014156|Ga0181518_10000096) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-bog 
                 3300014158|Ga0181521_10000063_92 
                 11 
                 N 
                 N 
                 685 
               
               
                 (3300014158|Ga0181521_10000063) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-bog 
                 3300014159|Ga0181530_10000119_98 
                 11 
                 N 
                 N 
                 685 
               
               
                 (3300014159|Ga0181530_10000119) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-bog 
                 3300014201|Ga0181537_10003972_13 
                 2 
                 N 
                 N 
                 702 
               
               
                 (3300014201|Ga0181537_10003972) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-bog 
                 3300014201|Ga0181537_10021284_1 
                 31 
                 N 
                 N 
                 629 
               
               
                 (3300014201|Ga0181537_10021284) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-bog 
                 3300014201|Ga0181537_10040512_3 
                 9 
                 N 
                 N 
                 560 
               
               
                 (3300014201|Ga0181537_10040512) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-bog 
                 3300014654|Ga0181525_10000532_4 
                 7 
                 N 
                 N 
                 618 
               
               
                 (3300014654|Ga0181525_10000532) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-bog 
                 3300014657|Ga0181522_10000394_52 
                 23 
                 N 
                 N 
                 591 
               
               
                 (3300014657|Ga0181522_10000394) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-bog 
                 3300014657|Ga0181522_10000394_53 
                 23 
                 N 
                 N 
                 610 
               
               
                 (3300014657|Ga0181522_10000394) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater lake 
                 3300009175|Ga0073936_10014029_2 
                 5 
                 N 
                 N 
                 717 
               
               
                 hypolimnion 
                   
                   
                   
                   
                   
               
               
                 (3300009175|Ga0073936_10014029) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300015360|Ga0163144_10020017_5 
                 5 
                 N 
                 N 
                 611 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300015360|Ga0163144_10020017) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300015360|Ga0163144_10020017_4 
                 5 
                 N 
                 N 
                 588 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300015360|Ga0163144_10020017) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300015360|Ga0163144_10033243_8 
                 2 
                 N 
                 N 
                 603 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300015360|Ga0163144_10033243) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300015360|Ga0163144_10033243_7 
                 2 
                 N 
                 N 
                 555 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300015360|Ga0163144_10033243) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300015360|Ga0163144_10062707_6 
                 24 
                 N 
                 N 
                 571 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300015360|Ga0163144_10062707) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300015360|Ga0163144_10062707_6 
                 24 
                 N 
                 N 
                 562 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300015360|Ga0163144_10062707) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300020057|Ga0163151_10006104_16 
                 5 
                 N 
                 N 
                 611 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300020057|Ga0163151_10006104) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300020186|Ga0163153_10017638_7 
                 6 
                 N 
                 N 
                 561 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300020186|Ga0163153_10017638) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300020195|Ga0163150_10003396_14 
                 19 
                 N 
                 N 
                 570 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300020195|Ga0163150_10003396) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300020203|Ga0163148_10001247_2 
                 13 
                 N 
                 N 
                 565 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300020203|Ga0163148_10001247) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300020203|Ga0163148_10001247_2 
                 13 
                 N 
                 N 
                 574 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300020203|Ga0163148_10001247) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300020213|Ga0163152_10009495_14 
                 15 
                 N 
                 N 
                 571 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300020213|Ga0163152_10009495) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300020213|Ga0163152_10009495_14 
                 15 
                 N 
                 N 
                 562 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300020213|Ga0163152_10009495) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300020219|Ga0163146_10006198_18 
                 5 
                 N 
                 N 
                 611 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300020219|Ga0163146_10006198) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300020596|Ga0163149_10010333_13 
                 8 
                 N 
                 N 
                 611 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300020596|Ga0163149_10010333) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater microbial 
                 3300020596|Ga0163149_10010333_12 
                 8 
                 N 
                 N 
                 588 
               
               
                 mat 
                   
                   
                   
                   
                   
               
               
                 (3300020596|Ga0163149_10010333) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater sediment 
                 3300004174|Ga0066406_1000030_21 
                 6 
                 N 
                 N 
                 593 
               
               
                 (3300004174|Ga0066406_1000030) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater sediment 
                 3300004200|Ga0066422_1000628_7 
                 6 
                 N 
                 N 
                 593 
               
               
                 (3300004200|Ga0066422_1000628) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater sediment 
                 3300004205|Ga0066415_1000057_23 
                 6 
                 N 
                 N 
                 593 
               
               
                 (3300004205|Ga0066415_1000057) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-freshwater sediment 
                 3300004565|Ga0066503_104695_4 
                 6 
                 N 
                 N 
                 593 
               
               
                 (3300004565|Ga0066503_104695) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-glacier valley 
                 3300009686|Ga0123338_10029047_2 
                 4 
                 N 
                 N 
                 535 
               
               
                 (3300009686|Ga0123338_10029047) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-groundwater 
                 3300001242|C687J13896_1000006_134 
                 24 
                 N 
                 N 
                 599 
               
               
                 (3300001242|C687J13896_1000006) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-groundwater 
                 3300005236|Ga0066636_10020712_3 
                 8 
                 N 
                 N 
                 588 
               
               
                 (3300005236|Ga0066636_10020712) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-groundwater 
                 3300014208|Ga0172379_10007070_15 
                 3 
                 N 
                 N 
                 623 
               
               
                 (3300014208|Ga0172379_10007070) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-groundwater 
                 3300014208|Ga0172379_10014650_2 
                 5 
                 N 
                 N 
                 612 
               
               
                 (3300014208|Ga0172379_10014650) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-groundwater 
                 3300014613|Ga0180008_1000021_8 
                 6 
                 N 
                 N 
                 627 
               
               
                 (3300014613|Ga0180008_1000021) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-groundwater 
                 3300014613|Ga0180008_1000021_9 
                 6 
                 N 
                 N 
                 658 
               
               
                 (3300014613|Ga0180008_1000021) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-groundwater 
                 3300014656|Ga0180007_10000195_44 
                 3 
                 N 
                 N 
                 627 
               
               
                 (3300014656|Ga0180007_10000195) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-groundwater 
                 3300014656|Ga0180007_10000195_48 
                 3 
                 N 
                 N 
                 658 
               
               
                 (3300014656|Ga0180007_10000195) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-groundwater 
                 3300014656|Ga0180007_10004731_7 
                 3 
                 N 
                 N 
                 560 
               
               
                 (3300014656|Ga0180007_10004731) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-groundwater 
                 3300014656|Ga0180007_10004731_5 
                 3 
                 N 
                 N 
                 561 
               
               
                 (3300014656|Ga0180007_10004731) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-groundwater 
                 3300015370|Ga0180009_10002661_7 
                 8 
                 N 
                 N 
                 589 
               
               
                 (3300015370|Ga0180009_10002661) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-peatland 
                 3300009760|Ga0116131_1003961_2 
                 5 
                 N 
                 N 
                 606 
               
               
                 (3300009760|Ga0116131_1003961) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-peatland 
                 3300018019|Ga0187874_10017489_1 
                 4 
                 N 
                 N 
                 623 
               
               
                 (3300018019|Ga0187874_10017489) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-peatland 
                 3300018025|Ga0187885_10005575_2 
                 6 
                 N 
                 N 
                 619 
               
               
                 (3300018025|Ga0187885_10005575) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-peatland 
                 3300018025|Ga0187885_10005575_1 
                 6 
                 N 
                 N 
                 642 
               
               
                 (3300018025|Ga0187885_10005575) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-peatland 
                 3300018057|Ga0187858_10035455_2 
                 2 
                 N 
                 N 
                 623 
               
               
                 (3300018057|Ga0187858_10035455) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-polar desert sand 
                 3300012183|Ga0136624_1011435_1 
                 3 
                 N 
                 N 
                 556 
               
               
                 (3300012183|Ga0136624_1011435) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-polar desert sand 
                 3300012682|Ga0136611_10000100_4 
                 12 
                 N 
                 N 
                 582 
               
               
                 (3300012682|Ga0136611_10000100) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013127|Ga0172365_10004082_5 
                 2 
                 N 
                 N 
                 547 
               
               
                 (3300013127|Ga0172365_10004082) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013127|Ga0172365_10004082_3 
                 2 
                 N 
                 N 
                 538 
               
               
                 (3300013127|Ga0172365_10004082) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013127|Ga0172365_10033732_1 
                 2 
                 N 
                 N 
                 610 
               
               
                 (3300013127|Ga0172365_10033732) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013128|Ga0172366_10016188_4 
                 2 
                 N 
                 N 
                 547 
               
               
                 (3300013128|Ga0172366_10016188) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013128|Ga0172366_10018111_5 
                 6 
                 N 
                 N 
                 543 
               
               
                 (3300013128|Ga0172366_10018111) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013129|Ga0172364_10001281_26 
                 16 
                 N 
                 N 
                 593 
               
               
                 (3300013129|Ga0172364_10001281) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013129|Ga0172364_10017363_4 
                 2 
                 N 
                 N 
                 547 
               
               
                 (3300013129|Ga0172364_10017363) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013129|Ga0172364_10018773_2 
                 7 
                 N 
                 N 
                 543 
               
               
                 (3300013129|Ga0172364_10018773) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013129|Ga0172364_10045136_2 
                 2 
                 N 
                 N 
                 610 
               
               
                 (3300013129|Ga0172364_10045136) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013130|Ga0172363_10000480_22 
                 4 
                 N 
                 N 
                 593 
               
               
                 (3300013130|Ga0172363_10000480) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013130|Ga0172363_10009486_8 
                 2 
                 N 
                 N 
                 547 
               
               
                 (3300013130|Ga0172363_10009486) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013130|Ga0172363_10014785_2 
                 2 
                 N 
                 N 
                 566 
               
               
                 (3300013130|Ga0172363_10014785) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013133|Ga0172362_10012573_3 
                 2 
                 N 
                 N 
                 547 
               
               
                 (3300013133|Ga0172362_10012573) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013133|Ga0172362_10022806_8 
                 2 
                 N 
                 N 
                 566 
               
               
                 (3300013133|Ga0172362_10022806) 
                   
                   
                   
                   
                   
               
               
                 aquatic-freshwater-sediment 
                 3300013133|Ga0172362_10025871_2 
                 2 
                 N 
                 N 
                 610 
               
               
                 (3300013133|Ga0172362_10025871) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine 
                 3300010155|Ga0098047_10009758_2 
                 2 
                 N 
                 N 
                 620 
               
               
                 (3300010155|Ga0098047_10009758) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine-aqueous 
                 3300006805|Ga0075464_10026824_2 
                 10 
                 N 
                 N 
                 479 
               
               
                 (3300006805|Ga0075464_10026824) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine-aqueous 
                 3300006805|Ga0075464_10026824_2 
                 10 
                 N 
                 N 
                 481 
               
               
                 (3300006805|Ga0075464_10026824) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine-deep subsurface 
                 3300009149|Ga0114918_10020022_2 
                 5 
                 N 
                 N 
                 664 
               
               
                 (3300009149|Ga0114918_10020022) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine-diffuse hydrothermal 
                 3300006083|Ga0081762_1007854_6 
                 8 
                 N 
                 N 
                 572 
               
               
                 flow volcanic vent 
                   
                   
                   
                   
                   
               
               
                 (3300006083|Ga0081762_1007854) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine-freshwater to marine 
                 3300010354|Ga0129333_10000304_8 
                 6 
                 N 
                 N 
                 551 
               
               
                 saline gradient 
                   
                   
                   
                   
                   
               
               
                 (3300010354|Ga0129333_10000304) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine-freshwater to marine 
                 3300010354|Ga0129333_10000304_10 
                 6 
                 N 
                 N 
                 574 
               
               
                 saline gradient 
                   
                   
                   
                   
                   
               
               
                 (3300010354|Ga0129333_10000304) 
                   
                   
                   
                   
                   
               
               
                 aquatic-marine-pelagic marine 
                 3300009507|Ga0115572_10029017_2 
                 4 
                 N 
                 N 
                 600 
               
               
                 (3300009507|Ga0115572_10029017) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017963|Ga0180437_10000100_151 
                 17 
                 N 
                 N 
                 642 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017963|Ga0180437_10000100) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017963|Ga0180437_10000153_25 
                 10 
                 N 
                 N 
                 732 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017963|Ga0180437_10000153) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017963|Ga0180437_10000488_78 
                 6 
                 N 
                 N 
                 584 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017963|Ga0180437_10000488) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017963|Ga0180437_10000692_13 
                 5 
                 N 
                 N 
                 654 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017963|Ga0180437_10000692) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017963|Ga0180437_10006965_20 
                 6 
                 N 
                 N 
                 670 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017963|Ga0180437_10006965) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017963|Ga0180437_10006965_20 
                 6 
                 N 
                 N 
                 645 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017963|Ga0180437_10006965) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017963|Ga0180437_10073069_2 
                 7 
                 N 
                 N 
                 625 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017963|Ga0180437_10073069) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017971|Ga0180438_10000090_91 
                 10 
                 N 
                 N 
                 732 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017971|Ga0180438_10000090) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017971|Ga0180438_10000124_114 
                 5 
                 N 
                 N 
                 654 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017971|Ga0180438_10000124) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017971|Ga0180438_10000195_144 
                 17 
                 N 
                 N 
                 642 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017971|Ga0180438_10000195) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017971|Ga0180438_10013386_7 
                 8 
                 N 
                 N 
                 584 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017971|Ga0180438_10013386) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017971|Ga0180438_10021273_1 
                 6 
                 N 
                 N 
                 645 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017971|Ga0180438_10021273) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017971|Ga0180438_10044179_5 
                 3 
                 N 
                 N 
                 674 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017971|Ga0180438_10044179) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017971|Ga0180438_10056790_2 
                 6 
                 N 
                 N 
                 645 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017971|Ga0180438_10056790) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017971|Ga0180438_10072596_2 
                 3 
                 N 
                 N 
                 556 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017971|Ga0180438_10072596) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017987|Ga0180431_10022214_3 
                 6 
                 N 
                 N 
                 572 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017987|Ga0180431_10022214) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017987|Ga0180431_10041976_5 
                 11 
                 N 
                 N 
                 556 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017987|Ga0180431_10041976) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017989|Ga0180432_10002388_5 
                 6 
                 N 
                 N 
                 572 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017989|Ga0180432_10002388) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017989|Ga0180432_10021155_3 
                 20 
                 N 
                 N 
                 630 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017989|Ga0180432_10021155) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017989|Ga0180432_10021155_5 
                 20 
                 N 
                 N 
                 643 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017989|Ga0180432_10021155) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017989|Ga0180432_10043261_1 
                 2 
                 N 
                 N 
                 651 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017989|Ga0180432_10043261) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017989|Ga0180432_10045094_6 
                 4 
                 N 
                 N 
                 633 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017989|Ga0180432_10045094) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017991|Ga0180434_10002646_1 
                 6 
                 N 
                 N 
                 572 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017991|Ga0180434_10002646) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017991|Ga0180434_10013735_9 
                 9 
                 N 
                 N 
                 549 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017991|Ga0180434_10013735) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300017992|Ga0180435_10018121_11 
                 6 
                 N 
                 N 
                 642 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300017992|Ga0180435_10018121) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300018065|Ga0180430_10011859_2 
                 11 
                 N 
                 N 
                 560 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300018065|Ga0180430_10011859) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300018065|Ga0180430_10038979_3 
                 7 
                 N 
                 N 
                 567 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300018065|Ga0180430_10038979) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300018080|Ga0180433_10006034_17 
                 13 
                 N 
                 N 
                 575 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300018080|Ga0180433_10006034) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300018080|Ga0180433_10006034_18 
                 13 
                 N 
                 N 
                 598 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300018080|Ga0180433_10006034) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300018080|Ga0180433_10012134_6 
                 13 
                 N 
                 N 
                 610 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300018080|Ga0180433_10012134) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300018080|Ga0180433_10012134_6 
                 13 
                 N 
                 N 
                 642 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300018080|Ga0180433_10012134) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300018080|Ga0180433_10020043_6 
                 12 
                 N 
                 N 
                 640 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300018080|Ga0180433_10020043) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300018080|Ga0180433_10021337_5 
                 10 
                 N 
                 N 
                 549 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300018080|Ga0180433_10021337) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300018080|Ga0180433_10021840_7 
                 5 
                 N 
                 N 
                 584 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300018080|Ga0180433_10021840) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300018080|Ga0180433_10021840_7 
                 5 
                 N 
                 N 
                 601 
               
               
                 hypersaline lake sediment 
                   
                   
                   
                   
                   
               
               
                 (3300018080|Ga0180433_10021840) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300001256|JGI12210J13797_10495608_9 
                 5 
                 N 
                 N 
                 580 
               
               
                 hypersaline mat 
                   
                   
                   
                   
                   
               
               
                 (3300001256|JGI12210J13797_10495608) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300001256|JGI12210J13797_10495610_14 
                 7 
                 N 
                 N 
                 580 
               
               
                 hypersaline mat 
                   
                   
                   
                   
                   
               
               
                 (3300001256|JGI12210J13797_10495610) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300005917|Ga0075115_10002831_4 
                 14 
                 N 
                 N 
                 635 
               
               
                 saline lake 
                   
                   
                   
                   
                   
               
               
                 (3300005917|Ga0075115_10002831) 
                   
                   
                   
                   
                   
               
               
                 aquatic-non marine saline and alkaline- 
                 3300005918|Ga0075116_10002890_7 
                 3 
                 N 
                 N 
                 635 
               
               
                 saline lake 
                   
                   
                   
                   
                   
               
               
                 (3300005918|Ga0075116_10002890) 
                   
                   
                   
                   
                   
               
               
                 aquatic-sediment-groundwater 
                 3300011414|Ga0137442_1000121_10 
                 17 
                 N 
                 N 
                 631 
               
               
                 sediment 
                   
                   
                   
                   
                   
               
               
                 (3300011414|Ga0137442_1000121) 
                   
                   
                   
                   
                   
               
               
                 aquatic-sediment-groundwater 
                 3300011431|Ga0137438_1001223_2 
                 8 
                 N 
                 N 
                 631 
               
               
                 sediment 
                   
                   
                   
                   
                   
               
               
                 (3300011431|Ga0137438_1001223) 
                   
                   
                   
                   
                   
               
               
                 aquatic-sediment-groundwater 
                 3300011441|Ga0137452_1000071_9 
                 7 
                 N 
                 N 
                 553 
               
               
                 sediment 
                   
                   
                   
                   
                   
               
               
                 (3300011441|Ga0137452_1000071) 
                   
                   
                   
                   
                   
               
               
                 aquatic-thermal springs-hot spring 
                 3300006855|Ga0079044_1002244_2 
                 3 
                 N 
                 N 
                 625 
               
               
                 (3300006855|Ga0079044_1002244) 
                   
                   
                   
                   
                   
               
               
                 aquatic-thermal springs-hot spring 
                 3300006855|Ga0079044_1002244_2 
                 3 
                 N 
                 N 
                 649 
               
               
                 (3300006855|Ga0079044_1002244) 
                   
                   
                   
                   
                   
               
               
                 aquatic-thermal springs-hot spring 
                 3300009503|Ga0123519_10000481_19 
                 8 
                 N 
                 N 
                 598 
               
               
                 (3300009503|Ga0123519_10000481) 
                   
                   
                   
                   
                   
               
               
                 aquatic-thermal springs-hot spring 
                 3300009503|Ga0123519_10000481_22 
                 8 
                 N 
                 N 
                 618 
               
               
                 (3300009503|Ga0123519_10000481) 
                   
                   
                   
                   
                   
               
               
                 aquatic-thermal springs-hot spring 
                 3300006865|Ga0073934_10032691_1 
                 2 
                 N 
                 N 
                 572 
               
               
                 sediment 
                   
                   
                   
                   
                   
               
               
                 (3300006865|Ga0073934_10032691) 
                   
                   
                   
                   
                   
               
               
                 aquatic-thermal springs-hypersaline mat 
                 3300001340|JGI20133J 14441_1002607_2 
                 11 
                 N 
                 N 
                 580 
               
               
                 (3300001340|JGI20133J14441_1002607) 
                   
                   
                   
                   
                   
               
               
                 arthropoda-digestive system-termite gut 
                 3300009784|Ga0123357_10000018_105 
                 2 
                 N 
                 N 
                 619 
               
               
                 (3300009784|Ga0123357_10000018) 
                   
                   
                   
                   
                   
               
               
                 arthropoda-digestive system-termite gut 
                 3300009784|Ga0123357_10000074_42 
                 2 
                 N 
                 N 
                 667 
               
               
                 (3300009784|Ga0123357_10000074) 
                   
                   
                   
                   
                   
               
               
                 arthropoda-digestive system-termite gut 
                 3300009784|Ga0123357_10000076_32 
                 2 
                 N 
                 N 
                 618 
               
               
                 (3300009784|Ga0123357_10000076) 
                   
                   
                   
                   
                   
               
               
                 groundwater metagenome 
                 BBPF01004549_6 
                 9 
                 N 
                 N 
                 584 
               
               
                 (BBPF01004549) 
                   
                   
                   
                   
                   
               
               
                 groundwater metagenome 
                 BBPG01001333_4 
                 8 
                 N 
                 N 
                 584 
               
               
                 (BBPG01001333) 
                   
                   
                   
                   
                   
               
               
                 human gut metagenome 
                 OGZV01009429_1 
                 3 
                 N 
                 N 
                 567 
               
               
                 (OGZV01009429) 
                   
                   
                   
                   
                   
               
               
                 human gut metagenome 
                 OKWZ01000119_10 
                 4 
                 N 
                 N 
                 563 
               
               
                 (OKWZ01000119) 
                   
                   
                   
                   
                   
               
               
                 human metagenome (ODGR01000476) 
                 ODGR01000476_16 
                 2 
                 N 
                 N 
                 567 
               
               
                 human metagenome (ODIG01000268) 
                 ODIG01000268_14 
                 4 
                 N 
                 N 
                 563 
               
               
                 human metagenome (ODIP01002140) 
                 ODIP01002140_2 
                 4 
                 N 
                 N 
                 567 
               
               
                 human metagenome (ODIW01000227) 
                 ODIW01000227_18 
                 4 
                 N 
                 N 
                 567 
               
               
                 human metagenome (ODJA01000260) 
                 ODJA01000260_38 
                 4 
                 N 
                 N 
                 563 
               
               
                 human metagenome (ODJP01000229) 
                 ODJP01000229_55 
                 4 
                 N 
                 N 
                 563 
               
               
                 human metagenome (ODKZ01007116) 
                 ODKZ01007116_1 
                 3 
                 N 
                 N 
                 567 
               
               
                 human metagenome (ODMO01000523) 
                 ODMO01000523_12 
                 4 
                 N 
                 N 
                 563 
               
               
                 human metagenome (ODTN01000195) 
                 ODTN01000195_35 
                 4 
                 N 
                 N 
                 563 
               
               
                 human metagenome (ODTP01000194) 
                 ODTP01000194_18 
                 4 
                 N 
                 N 
                 567 
               
               
                 human metagenome (ODWI01002981) 
                 ODWI01002981_3 
                 2 
                 N 
                 N 
                 563 
               
               
                 human metagenome (ODZZ01005262) 
                 ODZZ01005262_2 
                 4 
                 N 
                 N 
                 563 
               
               
                 human metagenome (OEED01000500) 
                 OEED01000500_25 
                 4 
                 N 
                 N 
                 567 
               
               
                 human metagenome (OEFT01000529) 
                 OEFT01000529_3 
                 4 
                 N 
                 N 
                 563 
               
               
                 marine sediment metagenome 
                 LAZR01002400_15 
                 20 
                 N 
                 N 
                 492 
               
               
                 (LAZR01002400) 
                   
                   
                   
                   
                   
               
               
                 marine sediment metagenome 
                 LAZR01002400_19 
                 20 
                 N 
                 N 
                 511 
               
               
                 (LAZR01002400) 
                   
                   
                   
                   
                   
               
               
                 metagenome (FLSK01003024) 
                 FLSK01003024_2 
                 4 
                 N 
                 N 
                 563 
               
               
                 metagenome (OFLM01000072) 
                 OFLM01000072_9 
                 4 
                 N 
                 N 
                 567 
               
               
                 metagenome (OFLO01000090) 
                 OFLO01000090_50 
                 4 
                 N 
                 N 
                 567 
               
               
                 metagenome (OFLU01000140) 
                 OFLU01000140_22 
                 3 
                 N 
                 N 
                 567 
               
               
                 metagenome (OFLV01000230) 
                 OF LVO1000230_3 
                 3 
                 N 
                 N 
                 567 
               
               
                 metagenome (OGCY01000078) 
                 OGCY01000078_30 
                 3 
                 N 
                 N 
                 567 
               
               
                 metagenome (OGJO01000473) 
                 OGJO01000473_2 
                 4 
                 N 
                 N 
                 563 
               
               
                 metagenome (0GJTO1OOO1O9) 
                 OGJT01000109_37 
                 3 
                 N 
                 N 
                 567 
               
               
                 metagenome (OGJZ01005194) 
                 OGJZ01005194_5 
                 2 
                 N 
                 N 
                 567 
               
               
                 metagenome (OGKO01001669) 
                 OGKO01001669_8 
                 4 
                 N 
                 N 
                 567 
               
               
                 metagenomes unclassified sequences. 
                 OFCI01000292_37 
                 5 
                 N 
                 N 
                 582 
               
               
                 (OFCI01000292) 
                   
                   
                   
                   
                   
               
               
                 plants-endosphere-populus endosphere 
                 3300006048|Ga0075363_100000001_25 
                 4 
                 N 
                 N 
                 634 
               
               
                 (3300006048|Ga0075363_100000001) 
                   
                   
                   
                   
                   
               
               
                 plants-endosphere-populus endosphere 
                 3300006048|Ga0075363_100000001_20 
                 4 
                 N 
                 N 
                 648 
               
               
                 (3300006048|Ga0075363_100000001) 
                   
                   
                   
                   
                   
               
               
                 plants-endosphere-populus endosphere 
                 3300006048|Ga0075363_100000020_49 
                 18 
                 N 
                 N 
                 488 
               
               
                 (3300006048|Ga0075363_100000020) 
                   
                   
                   
                   
                   
               
               
                 plants-endosphere-populus endosphere 
                 3300006178|Ga0075367_10000108_6 
                 4 
                 N 
                 N 
                 634 
               
               
                 (3300006178|Ga0075367_10000108) 
                   
                   
                   
                   
                   
               
               
                 plants-endosphere-populus endosphere 
                 3300006178|Ga0075367_10000108_6 
                 4 
                 N 
                 N 
                 648 
               
               
                 (3300006178|Ga0075367_10000108) 
                   
                   
                   
                   
                   
               
               
                 plants-endosphere-populus endosphere 
                 3300006195|Ga0075366_10000160_13 
                 4 
                 N 
                 N 
                 634 
               
               
                 (3300006195|Ga0075366_10000160) 
                   
                   
                   
                   
                   
               
               
                 plants-peat moss-host associated 
                 3300009500|Ga0116229_10010095_9 
                 21 
                 N 
                 N 
                 604 
               
               
                 (3300009500|Ga0116229_10010095) 
                   
                   
                   
                   
                   
               
               
                 plants-peat moss-host associated 
                 3300009701|Ga0116228_10018148_5 
                 4 
                 N 
                 N 
                 683 
               
               
                 (3300009701|Ga0116228_10018148) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizoplane-corn rhizosphere 
                 3300005577|Ga0068857_100000008_197 
                 15 
                 N 
                 N 
                 698 
               
               
                 (3300005577|Ga0068857_100000008) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizoplane-miscanthus 
                 3300005338|Ga0068868_100030384_5 
                 5 
                 N 
                 N 
                 637 
               
               
                 rhizosphere 
                   
                   
                   
                   
                   
               
               
                 (3300005338|Ga0068868_100030384) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizoplane-switchgrass 
                 3300005841|Ga0068863_100041042_2 
                 13 
                 N 
                 N 
                 693 
               
               
                 rhizosphere 
                   
                   
                   
                   
                   
               
               
                 (3300005841|Ga0068863_100041042) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizoplane-switchgrass 
                 3300013306|Ga0163162_10000022_153 
                 20 
                 N 
                 N 
                 586 
               
               
                 rhizosphere 
                   
                   
                   
                   
                   
               
               
                 (3300013306|Ga0163162_10000022) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-miscanthus 
                 3300009148|Ga0105243_10000126_60 
                 10 
                 N 
                 N 
                 626 
               
               
                 rhizosphere 
                   
                   
                   
                   
                   
               
               
                 (3300009148|Ga0105243_10000126) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-populus rhizosphere 
                 3300006846|Ga0075430_100000057_67 
                 3 
                 N 
                 N 
                 617 
               
               
                 (3300006846|Ga0075430_100000057) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-populus rhizosphere 
                 3300006853|Ga0075420_100000070_3 
                 3 
                 N 
                 N 
                 617 
               
               
                 (3300006853|Ga0075420_100000070) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-populus rhizosphere 
                 3300006854|Ga0075425_100000037_57 
                 22 
                 N 
                 N 
                 488 
               
               
                 (3300006854|Ga0075425_100000037) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-populus rhizosphere 
                 3300006903|Ga0075426_10000611_28 
                 2 
                 N 
                 N 
                 646 
               
               
                 (3300006903|Ga0075426_10000611) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-populus rhizosphere 
                 3300006914|Ga0075436_100000782_9 
                 2 
                 N 
                 N 
                 646 
               
               
                 (3300006914|Ga0075436_100000782) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-populus rhizosphere 
                 3300007076|Ga0075435_100000061_47 
                 2 
                 N 
                 N 
                 646 
               
               
                 (3300007076|Ga0075435_100000061) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-populus rhizosphere 
                 3300007076|Ga0075435_100000750_29 
                 22 
                 N 
                 N 
                 488 
               
               
                 (3300007076|Ga0075435_100000750) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-populus rhizosphere 
                 3300009100|Ga0075418_10076301_2 
                 6 
                 N 
                 N 
                 710 
               
               
                 (3300009100|Ga0075418_10076301) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-populus rhizosphere 
                 3300009100|Ga0075418_10076301_2 
                 6 
                 N 
                 N 
                 713 
               
               
                 (3300009100|Ga0075418_10076301) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-populus rhizosphere 
                 3300009156|Ga0111538_10081463_8 
                 3 
                 N 
                 N 
                 558 
               
               
                 (3300009156|Ga0111538_10081463) 
                   
                   
                   
                   
                   
               
               
                 plants-rhizosphere-switchgrass 
                 3300005548|Ga0070665_100000073_173 
                 7 
                 N 
                 N 
                 597 
               
               
                 rhizosphere 
                   
                   
                   
                   
                   
               
               
                 (3300005548|Ga0070665_100000073) 
                   
                   
                   
                   
                   
               
               
                 soil metagenome (OBLM01000011) 
                 OBLM01000011_1 
                 2 
                 N 
                 N 
                 635 
               
               
                 soil metagenome (OCTA010000646) 
                 OCTA010000646_37 
                 6 
                 N 
                 N 
                 628 
               
               
                 soil metagenome (ODAK010001378) 
                 ODAK010001378_33 
                 5 
                 N 
                 N 
                 617 
               
               
                 soil metagenome (ODAK010029943) 
                 ODAK010029943_5 
                 11 
                 N 
                 N 
                 595 
               
               
                 soil metagenome (ODAK010029943) 
                 ODAK010029943_6 
                 11 
                 N 
                 N 
                 638 
               
               
                 terrestrial-soil 
                 3300005602|Ga0070762_10000001_34 
                 50 
                 N 
                 N 
                 628 
               
               
                 (3300005602|Ga0070762_10000001) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300005602|Ga0070762_10000001_32 
                 50 
                 N 
                 N 
                 660 
               
               
                 (3300005602|Ga0070762_10000001) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300006796|Ga0066665_10000988_15 
                 2 
                 N 
                 N 
                 628 
               
               
                 (3300006796|Ga0066665_10000988) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300018429|Ga0190272_10000030_113 
                 4 
                 N 
                 N 
                 622 
               
               
                 (3300018429|Ga0190272_10000030) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300018432|Ga0190275_10000082_154 
                 10 
                 N 
                 N 
                 605 
               
               
                 (3300018432|Ga0190275_10000082) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300018481|Ga0190271_10027355_3 
                 7 
                 N 
                 N 
                 596 
               
               
                 (3300018481|Ga0190271_10027355) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300019874|Ga0193744_1000265_21 
                 4 
                 N 
                 N 
                 488 
               
               
                 (3300019874|Ga0193744_1000265) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300020021|Ga0193726_1013919_1 
                 3 
                 N 
                 N 
                 711 
               
               
                 (3300020021|Ga0193726_1013919) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300020021|Ga0193726_1013919_1 
                 3 
                 N 
                 N 
                 745 
               
               
                 (3300020021|Ga0193726_1013919) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300020034|Ga0193753_10002988_10 
                 2 
                 N 
                 N 
                 630 
               
               
                 (3300020034|Ga0193753_10002988) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300020034|Ga0193753_10002988_9 
                 2 
                 N 
                 N 
                 669 
               
               
                 (3300020034|Ga0193753_10002988) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300020156|Ga0196970_1000866_40 
                 6 
                 N 
                 N 
                 559 
               
               
                 (3300020156|Ga0196970_1000866) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300020579|Ga0210407_10000200_14 
                 8 
                 N 
                 N 
                 621 
               
               
                 (3300020579|Ga0210407_10000200) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300020580|Ga0210403_10000550_35 
                 8 
                 N 
                 N 
                 621 
               
               
                 (3300020580|Ga0210403_10000550) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300020580|Ga0210403_10001296_17 
                 5 
                 N 
                 N 
                 518 
               
               
                 (3300020580|Ga0210403_10001296) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300020581|Ga0210399_10010852_9 
                 9 
                 N 
                 N 
                 596 
               
               
                 (3300020581|Ga0210399_10010852) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil 
                 3300020583|Ga0210401_10033176_5 
                 3 
                 N 
                 N 
                 518 
               
               
                 (3300020583|Ga0210401_10033176) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-agricultural soil 
                 3300005435|Ga0070714_100002341_12 
                 11 
                 N 
                 N 
                 521 
               
               
                 (3300005435|Ga0070714_100002341) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-agricultural soil 
                 3300009095|Ga0079224_100000262_28 
                 6 
                 N 
                 N 
                 573 
               
               
                 (3300009095|Ga0079224_100000262) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-agricultural soil 
                 3300009095|Ga0079224_100170797_3 
                 3 
                 N 
                 N 
                 618 
               
               
                 (3300009095|Ga0079224_100170797) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-bog forest soil 
                 3300010343|Ga0074044_10013672_1 
                 9 
                 N 
                 N 
                 672 
               
               
                 (3300010343|Ga0074044_10013672) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-bog forest soil 
                 3300010343|Ga0074044_10041345_4 
                 3 
                 N 
                 N 
                 561 
               
               
                 (3300010343|Ga0074044_10041345) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-corn, switchgrass and 
                 3300005468|Ga0070707_100000083_12 
                 3 
                 N 
                 N 
                 628 
               
               
                 miscanthus rhizosphere 
                   
                   
                   
                   
                   
               
               
                 (3300005468|Ga0070707_100000083) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-corn, switchgrass and 
                 3300006163|Ga0070715_10000067_44 
                 42 
                 N 
                 N 
                 690 
               
               
                 miscanthus rhizosphere 
                   
                   
                   
                   
                   
               
               
                 (3300006163|Ga0070715_10000067) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-fen 
                 3300014498|Ga0182019_10003703_1 
                 4 
                 N 
                 N 
                 630 
               
               
                 (3300014498|Ga0182019_10003703) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-forest soil 
                 3300001131|JGI12631J13338_1000296_13 
                 22 
                 N 
                 N 
                 674 
               
               
                 (3300001131|JGI12631J13338_1000296) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-forest soil 
                 3300001593|JGI12635J15846_10002852_1 
                 22 
                 N 
                 N 
                 674 
               
               
                 (3300001593|JGI12635J15846_10002852) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-groundwater sand 
                 3300009813|Ga0105057_1000075_5 
                 8 
                 N 
                 N 
                 600 
               
               
                 (3300009813|Ga0105057_1000075) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-groundwater sand 
                 3300009813|Ga0105057_1000075_5 
                 8 
                 N 
                 N 
                 604 
               
               
                 (3300009813|Ga0105057_1000075) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-palsa 
                 3300014489|Ga0182018_10031574_1 
                 4 
                 N 
                 N 
                 525 
               
               
                 (3300014489|Ga0182018_10031574) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-palsa 
                 3300014501|Ga0182024_10047267_8 
                 13 
                 N 
                 N 
                 643 
               
               
                 (3300014501|Ga0182024_10047267) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-palsa 
                 3300014501|Ga0182024_10150440_2 
                 3 
                 N 
                 N 
                 640 
               
               
                 (3300014501|Ga0182024_10150440) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-peatlands soil 
                 3300001356|JGI12269J14319_10001968_12 
                 5 
                 N 
                 N 
                 552 
               
               
                 (3300001356|JGI12269J14319_10001968) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-pond soil 
                 3300007533|Ga0102944_1012316_2 
                 13 
                 N 
                 N 
                 622 
               
               
                 (3300007533|Ga0102944_1012316) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-rice paddy soil 
                 3300005903|Ga0075279_10000001_30 
                 5 
                 N 
                 N 
                 701 
               
               
                 (3300005903|Ga0075279_10000001) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-surface soil 
                 3300005524|Ga0070737_10002282_10 
                 8 
                 N 
                 N 
                 739 
               
               
                 (3300005524|Ga0070737_10002282) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-surface soil 
                 3300005524|Ga0070737_10031205_1 
                 5 
                 N 
                 N 
                 615 
               
               
                 (3300005524|Ga0070737_10031205) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-surface soil 
                 3300005524|Ga0070737_10031205_1 
                 5 
                 N 
                 N 
                 628 
               
               
                 (3300005524|Ga0070737_10031205) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-surface soil 
                 3300005534|Ga0070735_10023967_5 
                 2 
                 N 
                 N 
                 607 
               
               
                 (3300005534|Ga0070735_10023967) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-surface soil 
                 3300005542|Ga0070732_10013271_3 
                 2 
                 N 
                 N 
                 520 
               
               
                 (3300005542|Ga0070732_10013271) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-terrestrial soil 
                 3300010373|Ga0134128_10000310_109 
                 4 
                 N 
                 N 
                 670 
               
               
                 (3300010373|Ga0134128_10000310) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-terrestrial soil 
                 3300010373|Ga0134128_10011458_1 
                 4 
                 N 
                 N 
                 675 
               
               
                 (3300010373|Ga0134128_10011458) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-terrestrial soil 
                 3300010373|Ga0134128_10096594_3 
                 4 
                 N 
                 N 
                 674 
               
               
                 (3300010373|Ga0134128_10096594) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-terrestrial soil 
                 3300010400|Ga0134122_10000107_57 
                 2 
                 N 
                 N 
                 631 
               
               
                 (3300010400|Ga0134122_10000107) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-terrestrial soil 
                 3300010401|Ga0134121_10002041_17 
                 2 
                 N 
                 N 
                 564 
               
               
                 (3300010401|Ga0134121_10002041) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical forest soil 
                 3300004633|Ga0066395_10000027_32 
                 9 
                 N 
                 N 
                 586 
               
               
                 (3300004633|Ga0066395_10000027) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical forest soil 
                 3300005332|Ga0066388_100004304_4 
                 7 
                 N 
                 N 
                 644 
               
               
                 (3300005332|Ga0066388_100004304) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical forest soil 
                 3300005332|Ga0066388_100004304_2 
                 7 
                 N 
                 N 
                 619 
               
               
                 (3300005332|Ga0066388_100004304) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical forest soil 
                 3300005764|Ga0066903_100000051_27 
                 9 
                 N 
                 N 
                 586 
               
               
                 (33000057641Ga0066903_100000051) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical forest soil 
                 3300010047|Ga0126382_10001209_14 
                 5 
                 N 
                 N 
                 651 
               
               
                 (3300010047|Ga0126382_10001209) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical forest soil 
                 3300010047|Ga0126382_10001209_12 
                 5 
                 N 
                 N 
                 619 
               
               
                 (3300010047|Ga0126382_10001209) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical forest soil 
                 3300010048|Ga0126373_10000093_102 
                 4 
                 N 
                 N 
                 598 
               
               
                 (3300010048|Ga0126373_10000093) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical forest soil 
                 3300010366|Ga0126379_10001683_10 
                 6 
                 N 
                 N 
                 619 
               
               
                 (3300010366|Ga0126379_10001683) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical forest soil 
                 3300010376|Ga0126381_100020658_4 
                 3 
                 N 
                 N 
                 592 
               
               
                 (3300010376|Ga0126381_100020658) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical forest soil 
                 3300010398|Ga0126383_10032213_5 
                 2 
                 N 
                 N 
                 570 
               
               
                 (3300010398|Ga0126383_10032213) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical peatland 
                 3300017961|Ga0187778_10004454_1 
                 4 
                 N 
                 N 
                 612 
               
               
                 (3300017961|Ga0187778_10004454) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical peatland 
                 3300017970|Ga0187783_10000008_23 
                 16 
                 N 
                 N 
                 565 
               
               
                 (3300017970|Ga0187783_10000008) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical peatland 
                 3300017972|Ga0187781_10019688_5 
                 13 
                 N 
                 N 
                 705 
               
               
                 (3300017972|Ga0187781_10019688) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-tropical peatland 
                 3300018064|Ga0187773_10011230_2 
                 2 
                 N 
                 N 
                 640 
               
               
                 (3300018064|Ga0187773_10011230) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-vadose zone soil 
                 3300012204|Ga0137374_10001132_4 
                 22 
                 N 
                 N 
                 666 
               
               
                 (3300012204|Ga0137374_10001132) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-vadose zone soil 
                 3300012210|Ga0137378_10000107_47 
                 3 
                 N 
                 N 
                 670 
               
               
                 (3300012210|Ga0137378_10000107) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-vadose zone soil 
                 3300012532|Ga0137373_10000316_4 
                 22 
                 N 
                 N 
                 666 
               
               
                 (3300012532|Ga0137373_10000316) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-vadose zone soil 
                 3300012532|Ga0137373_10000407_43 
                 26 
                 N 
                 N 
                 479 
               
               
                 (3300012532|Ga0137373_10000407) 
                   
                   
                   
                   
                   
               
               
                 terrestrial-soil-vadose zone soil 
                 3300012930|Ga0137407_10020190_4 
                 5 
                 N 
                 N 
                 545 
               
               
                 (3300012930|Ga0137407_10020190) 
                   
                   
                   
                   
                   
               
               
                 wastewater-nutrient removal- 
                 3300005987|1071089|scaffold14955_2 
                 13 
                 N 
                 N 
                 632 
               
               
                 wastewater effluent 
                   
                   
                   
                   
                   
               
               
                 (3300005987|1071089|scaffold14955) 
                   
                   
                   
                   
                   
               
               
                 wastewater-nutrient removal- 
                 3300005988|1071091|scaffold06014_8 
                 13 
                 N 
                 N 
                 632 
               
               
                 wastewater effluent 
                   
                   
                   
                   
                   
               
               
                 (3300005988|1071091|scaffold06014) 
                   
                   
                   
                   
                   
               
               
                 wastewater-nutrient removal- 
                 3300006056|1071094|scaffold118627_2 
                 5 
                 N 
                 N 
                 632 
               
               
                 wastewater effluent 
                   
                   
                   
                   
                   
               
               
                 (3300006056|1071094|scaffold 118627) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 Amino Acid Sequences of Representative CLUST.018837 Effector Proteins* 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 &gt;WP_081130164.1 
               
               
                 [ Metallibacterium   scheffleri ] 
               
               
                 MKLSPALPPTGDVLIYEYGARVDGDCLPAVGDQIAKARRLYNDLVAVIRGIVDEMRGFVLKHAGSEALALQARIDG 
               
               
                 LSEAFDAARAANDEDRMKQIAGERRALWAELGEQVKAVRKAHRAEIQELFLSRIGKKSTCDTYQMRCKAVGDGLGW 
               
               
                 ATANQVLDAALQAFKTSFQRGQAPRFARGEEKIQDTLTLQFTAAGGVPVAALLSGDHSELSMVSSCGRRKYGSFSF 
               
               
                 RLGSASADTYANGTWQYHRPLPDGATVGLARLVRRSVGKDFKWALQLMVKRPATEPAMMEGRKPLVAVHFGWAGDA 
               
               
                 SGRRVAGITDGADPGVARVLQLPVEVEDGIRRAAEFQSARDEARDVIMTTIKNIAWGDAVACLGESSQFMHGSEPW 
               
               
                 LRARLSEELSTIRRLPAQHVAPRRLHRLCGLLRATNQMHDELEAWRKQDRLAWQASAHMARRARNLRKDFYRRVAI 
               
               
                 DLARRYSAIVLEPLDLAAAALKVNEITGEKTEFAKKARSGRVVAAIYELESSIRWAAAKSGTALLDLSGAETAARC 
               
               
                 GICGGASQSDESNSQVLHCVECGAELDRKKNGAAIAWQFAHENLDEAVTDFWAAVIAQRCEHAEKTREKKAKMAEG 
               
               
                 RRLARTLSAGVSAVGSRNV (SEQ ID NO: 1) 
               
               
                   
               
               
                 &gt;WP_018079340.1 
               
               
                 [ Thiobacillus denitrificans  DSM 12475] 
               
               
                 MSEIKPSLLPQGNVLIYEYGARLDKDCIQAVGDQIIKSRRLYNDLVATIRGIVTEMKAFVLEKSGPDAQRCQEEID 
               
               
                 ALNAAFDAARAENNEDAMKCIAESRREKWRELAVFVKEARKNHRSDIQSMYLSRIGKNSACETYRIRSKAVADGLG 
               
               
                 WATANQVLDAALTAFKKSFARGNAPRFAVGEDKDQDTLTLQFTAAGGVPVDTILAGKHGEVALSPTNGCGPRKYGE 
               
               
                 LRFRLGAAKAATNATGTWQYHRPLPDGATAGLCRLIRRRVGKDYKWAIQMQVKRPPIEQEALAGRKPLVAVHFGWA 
               
               
                 ANDEGRCVAGITDGADPGQAYVLKLPAEVEQSLVRSSAIQSERDSARDAIVPRLKEIEVPDMDIESVESLPPDSPE 
               
               
                 VRLARAADELKAIHRLPANHVAIRRLHRLCGMLRDVDFLPEWLEDWRKEDRLQWQSAAHIARRARNTRKGFYRQTA 
               
               
                 IDLARQYSSIVLEPLDLAKAAVKIDEITGERTEFAKKARAGRVVAALYELESAIRWAAAKAGSAMFELTGETASRC 
               
               
                 SICGGDVLPDETNGQLLHCTECGADLDRKQNGAAMAWQLANDDLESLVEAFWTETFAARRSAENEQAEKKQKMAEG 
               
               
                 RRKARTPIGGENTEVSRDSGNGANA (SEQ ID NO: 2) 
               
               
                   
               
               
                 &gt;WP_064217851.1 
               
               
                 [ Acidithiobacillus   ferrooxidans ] 
               
               
                 MSTITYEYGVRLEPDCIQHVDHQIILARGTYNEMIAAMRSVHDAAQSFQMEKAGPEGRAIAARIEALNTAFKEARA 
               
               
                 QQQEESLLQAIAVERRQCWRDLGVILKGVRQEHKKTLQEVFYNRIGINKGTDTYAIRCKAVADGLGWATAQDVLNR 
               
               
                 AIIAWKMSMKLGRAPQFARGDEKTQDALTVQFTEKGGMPKDKMLEGESAVIGVEQPENTGKRAYGHFWFRLGSASE 
               
               
                 GHYARGTIQWHRDLPEDASMASARLVRKRTGCKMKYYMQYVINTAQIRQVSDHARKALLAVHMGWSADISGRRVCG 
               
               
                 ITDAADPELAQIIQLPPEIERNIQRAANIQGKRDQARDEIAPKIRAFDGSLPPEWDESTQDYWSHWKVLPANHMAA 
               
               
                 SRIHAWRKRLGDFAPEWMAEWCKADRMLWIAATHTAQRARNRRKDFYRNLAKTWASQYEAIVIEKPDIKKAAKILD 
               
               
                 EATGERTEFAKKARAGRVLASLYTLDSAIRWACQKNGTAILDMNGEKTAATCAMCASEAIRADTEDGQVLHCADCG 
               
               
                 AVLDRKKNGAAVAWQLVNEQRENLVEEYWAEQLNKEREAAEAKASRLEKMQAARRAKREPALAD (SEQ ID NO: 
               
               
                 3) 
               
               
                   
               
               
                 &gt;JMEB01000165_11 
               
               
                 [ Acidithiobacillus   thiooxidans ] 
               
               
                 MNLKVCGDIDDQIRRARAMYNNIIAVMRGIYDEMQTFTMEHAGPEGQALHEKIVAANVAFDAAKADNDEPRMKQIA 
               
               
                 MERRELWKALSIILKEVRKEHKNTLKERFYSRIGNNSSTETYQCRAEAIVGGLGYATATKVLDNALKAWQMSMVKG 
               
               
                 KAPRFARGEEKDQDTLTLQFSQAGGVPVEDIFTGKRKDIGIEYPKKGFGPRSYSAFRFRLGAASEESYAEGTVQLH 
               
               
                 RAIPENARIAMAHLTRKKAGRKYQYELQLLATLAEPINLLPDHRRKPLVAIHFGWSGDEEGRRLAGIADNADPLEA 
               
               
                 RLLTLPPDIEDDIREASALQAKRDTYRDEVFLRLKEENTLPTKGETPLSEHWNKIRKLPAQHVSANRMHHLAWLVK 
               
               
                 SELIEIPEWFETWRKADQRMWVQATSLARRARNRRKKYYEKVAIDLASRYEAILIEMPDLKKSAEKVNEKTGEKTE 
               
               
                 FAKKARSGRVIAALYVLESAIQWAACKHGSAVLKIKGEKTASVCAFCEGDHLEEKEEHDSQTLYCPDCGSTVDRKL 
               
               
                 NGAANAWKRAASDLESLVTEYWEETREKQMGKAETKRLKSEKMAEARRLKRQAASQASAGA (SEQ ID NO: 4) 
               
               
                   
               
               
                 &gt;WP_051690567.1 
               
               
                 [ Acidithiobacillus   thiooxidans ] 
               
               
                 MSQIKIVPQINGSQLVYKYGVRMNLKVCGDIDDQIRRARAMYNNIIAVMRGIYDEMQTFTMEHAGPEGQALHEKIV 
               
               
                 AANVAFDAAKADNDEPRMKQIAMERRELWKALSIILKEVRKEHKNTLKERFYSRIGNNSSTETYQCRAEAIVGGLG 
               
               
                 YATATKVLDNALKAWQMSMVKGKAPRFARGEEKDQDTLTLQFSQAGGVPVEDIFTGKRKDIGIEYPKKGFGPRSYS 
               
               
                 AFRFRLGAASEESYAEGTVQLHRAIPENARIAMAHLTRKKAGRKYQYELQLLATLAEPINLLPDHRRKPLVAIHFG 
               
               
                 WSGDEEGRRLAGIADNADPLEARLLTLPPDIEDDIREASALQAKRDTYRDEVFLRLKEENTLPTKGETPLSEHWNK 
               
               
                 IRKLPAQHVSANRMHHLAWLVKSELIEIPEWFETWRKADQRMWVQATSLARRARNRRKKYYEKVAIDLASRYEAIL 
               
               
                 IEMPDLKKSAEKVNEKTGEKTEFAKKARSGRVIAALYVLESAIQWAACKHGSAVLKIKGEKTASVCAFCEGDHLEE 
               
               
                 KEEHDSQTLYCPDCGSTVDRKLNGAANAWKRAASDLESLVTEYWEETREKQMGKAETKRLKSEKMAEARRLKRQAA 
               
               
                 SQASAGA (SEQ ID NO: 5) 
               
               
                   
               
               
                 &gt;OJW42488.1 
               
               
                 [ Rhodanobacter  sp. 67-28] 
               
               
                 MKITPASLPQGDVRIYEFGARLDKDCLEAANDQFFKAHQLYNELVACMQGTLRDMQAYLLENAGQEAQSAQARVEA 
               
               
                 LNEALSAAKAANDEDTMKAVASERREVWRTLAALLRDTRKVHKATLQERFLCRIGRKSTCATYQLRCDAVAAGLGW 
               
               
                 ATANATLDAALLAFKSSFVQGRAPRFAKAGESTQDSLTLQFTAAGGVSVSTLLEGRHTEFRVKASGGCGPRRYGTL 
               
               
                 EFRLGPASSETYAAGTWQYHRAMPDDGAVGLVRLVRRRLGPKFQWAIQFQVRSPLPVNDSVGERKPLVALHAGWAA 
               
               
                 DLTGRRVAGIADGADPGLARVLQLPPEIEAGLQHSGEVESARSVARDNVVATLKAHAWPQDLLDAAEQPTEDATPE 
               
               
                 ATRRSQAAADLLVIRRLPATHVAIRRLHRLAQRLRDTADLPDWFEAWRKEDKLAWQKAAHAAKRARNRRKGFYREV 
               
               
                 ALGLATGYQAIVLQPLDLESAAKKVDDASGERTEFGRKARSGRVVAAIYELEGAIRWAAAKCGTAVLELTGETAGH 
               
               
                 CAYCGGAVKPVEDDSQRLACTQCGADIDRKRNGAALAWQATEESLPTLVEDFWRETLAARDGAAAKRKEKREKVAE 
               
               
                 ARRASRVVE (SEQ ID NO: 6) 
               
               
                   
               
               
                 &gt;LNFM01018448_6 
               
               
                 [activated carbon metagenome] 
               
               
                 MTMEQAMVGAVYESASAAGEEVMASRNETTQEETDAFSVSFSTVGPAEVMVYEFGCRIAKGDLDHLRDQLWRSRRL 
               
               
                 FNEVAAQINQTVDEAKCFLSDRAGPVAGEIAVRLGVLDTEWKSAKALDDREALVKIAGERKSLRTRWYGLLHKARR 
               
               
                 EHGTELRERYLSRIGNRVGAATYALRCAAVDDGLDWAMGNEALAAALGAFGKQWPRFKPISFRRFDDPTEVATLQF 
               
               
                 TAAGGVAVADILADKHSQIGMQLGREQAGRRMYVPFRMKLGSGAQKKAITGTVLYHRPLPAGASVPIARLVGRRIG 
               
               
                 KDVKHYLQFMVKLKQAEQPGANSKRAPMGVAHLGWYYQPTGRRLAEVASSEDPGLSEQLTLPIEVAELLDRARELD 
               
               
                 GQRSKLRDGIVGSVVRELPVEGAPEQIAEEVAALRKMRIEHVAPRRLGKLVFIWSRNCADWQRDRLKAMQAWRLED 
               
               
                 RMLWQSSAHTARRARNRRRKHYEQLALSLAGKFTNILIDVPDLAQVAKVKDEDTGEHNGLGARARGGRFDAALYEL 
               
               
                 TSAIEKAGARLGCNVGKIKGPTASTCAHCGGTTKMGKTVRDVVCEACGAVEDRAASAAAVAFGWASQNKDAVDEAV 
               
               
                 AAALDADRAKATRAAERKEKMAIARATSRAARTESDEDSADGSRELK (SEQ ID NO: 7) 
               
               
                   
               
               
                 &gt;3300004774|Ga0007794_10001723_8 
               
               
                 [aquatic-freshwater] 
               
               
                 MTIKVYKFGLLDPVSGWDQTAIDVLFLRNKLWNNLVAMEHDKRQAYRNLLLDSDTELAALQARLDAIEVEKASLIT 
               
               
                 SKKALRAKARSRQVDTAEIDLEIKKLLEERKALGGQTKDLRERVKIEVKPLAAELDQQRYEKTKQLNKESGLWWCN 
               
               
                 SMTVIAAYEVGRLRAMREKNELRFHGFDGTGKYSVCRTGGFSLDHVMTGKLSFVSIRTLPIANLDDLSERGQRSRA 
               
               
                 RHHLTMIVLRATTEEGTKIRHEVTWPIILHRPLPDDCLIKQIQVLRKRVGDRFEWTCSITVDTPEELKARLDSPSI 
               
               
                 SVCGIDLGFRQVNNDLRVATLADSSGGLRYYTIGKDWLDSMDYVEAIQSDLSGTANSVWAQLRLILKELDEYPEAL 
               
               
                 RERITDMLKAGAKTPIRAMRAMQKTLSNEPDLMPDALALLDDWKKRIRRRTKEMHDLRDKLINRRKDIYRNIACEI 
               
               
                 ARDYSLVRIANLKLKDMVKLKRNDGTDTKLTDNARKNCNRAALSELTLYIQQACAKNGVALEKIDTTYMTRTCYQC 
               
               
                 GYLNPANTINLLLSCEGCGAEYDQDDNAAKNYLNATKPGTG (SEQ ID NO: 8) 
               
               
                   
               
               
                 &gt;3300004776|Ga0007800_10001775_2 
               
               
                 [aquatic-freshwater] 
               
               
                 MTIKVYKFGLLDPVSGWDQTAIDVLFLRNKLWNNLVAMEHDKRQAYRNLLLDSDTELAALQARLDAIEVEKASLIT 
               
               
                 SKKALRAKARSRQVDTAEIDLEIKKLLEERKALGGQTKDLRERVKIEVKPLAAELDQQRYEKTKQLNKESGLWWCN 
               
               
                 SMTVIAAYEVGRLRAMREKNELRFHGFDGTGKYSVCRTGGFSLDHVMTGKLSFVSIRTLPIANLDDLSERGQRSRA 
               
               
                 RHHLTMIVLRATTEEGTKIRHEVTWPIILHRPLPDDCLIKQIQVLRKRVGDRFEWTCSITVDTPEELKARLDSPSI 
               
               
                 SVCGIDLGFRQVNNDLRVATLADSSGGLRYYTIGKDWLDSMDYVEAIQSDLSGTANSVWAQLRLILKELDEYPEAL 
               
               
                 RERITDMLKAGAKTPIRAMRAMQKTLSNEPDLMPDALALLDDWKKRIRRRTKEMHDLRDKLINRRKDIYRNIACEI 
               
               
                 ARDYSLVRIANLKLKDMVKLKRNDGTDTKLTDNARKNCNRAALSELTLYIQQACAKNGVALEKIDTTYMTRTCYQC 
               
               
                 GYLNPANTINLLLSCEGCGAEYDQDDNAAKNYLNATKPGTG (SEQ ID NO: 8) 
               
               
                   
               
               
                 &gt;3300009004|Ga0100377_1000348_44 
               
               
                 [aquatic-freshwater-aquifer] 
               
               
                 MTNQENFSIKAAKTPSGDVLIYEFGARLDKECAAEVDKQIKQARGLYNNIVALMRDTMDEMRADLVENAGPVARET 
               
               
                 QAAIDALNLKFAEAKARDDEGAMLLIAQQRRELWAQLSALLKEVRASLKSEHKSRFFSRIGINSSCATYQLRSVAV 
               
               
                 KEGLGWGTANEILDNVLGAWKKSLAMGKAPRFVSAAEKMQDTLTLQFTAAGGISVVDLLSRSKGDMILTPPSEAGK 
               
               
                 RKYGSFQFRMGAASSNSYATGTWQYHRPLPEGSSVGVARLIRRRVGKDTKYAIQLQVKIKEGIEQAVRNRKPLATV 
               
               
                 HFGWAGDVEGRRVAGIADSAEPSSAQVIALPTEIEEMLARSTTIQGERDTERDNIVPVVKQLDPTKFDETLAEEVT 
               
               
                 ALNKLPAQHIAIRRLHRLCRHLGDVDMLPEALAEWRKADRMRWQSETHLARRARNQRKDFYRNIAINLARNYEVIA 
               
               
                 IEPLDLAKAAIKLDKMTGEKTELSKKARSGRVVAAIYELESAIRWAAVKTGAAVLELTAAKTASVCSICGGHVSDD 
               
               
                 TENSQILHCDDCGADLDRKQNGAAIAWQMVEPLREDLAVDYHQAKIDAARATKQKMVEKLGKLAEGRLKGREAKAG 
               
               
                 SAANPE (SEQ ID NO: 9) 
               
               
                   
               
               
                 &gt;3300004236|Ga0066449_1000007_83 
               
               
                 [aquatic-freshwater-freshwater sediment] 
               
               
                 MINCYKFGCLQPTAGFDQSAIEHLFLRNKLWNTLVALDHEFRQRYRDLMLNSDEKLKSVQDSIDSINQEIEDLVEN 
               
               
                 KMKLRQKERTKNIDSKLLDERINVLKAKRKTLSADSKTERERVKVEIKPQIDLLNTERYEAKKLAYKESGLWWGNY 
               
               
                 ETVVAAYDTASQKAMKSNTELRFKSFDGSGKFAVRFEDGGLTIDELKAGASNLCRIETLNTSAFQNLSQRSIKSKA 
               
               
                 RHSLTMTIYTFNDEKGKKQRKEITVPIIFHREMEEGKIKTIHLQRKRLGNQFTWSASFTLKNDIEPANVADHPATA 
               
               
                 SCGIDLGYRLVKDGLRVATVADSQNNVEYLVLPKSWIDRMDYTETLQSGLSEAMTLMWAKLKAEIAKIPEYPDAVA 
               
               
                 EIIKNMQKMGDRLPYKGIKRLYRVLKEQDATGSPVAGFNAVLDILKAWDKATYRQELEMVNLKDKLLKQREHIYRN 
               
               
                 FAAGLTKKYAHIVVEDMGLAELAKTEKSETETNDMPNAVKANRQRASLYSLVEAIRLSAAKVGSYFEKSKAAYSSM 
               
               
                 TCNVCGHLNPKTQNIHQSCESCNTMYDVDENAARNFLKGEYINEKVLKQG (SEQ ID NO: 10) 
               
               
                   
               
               
                 &gt;3300009432|Ga0115005_10004282_5 
               
               
                 [aquatic-marine] 
               
               
                 MATRVYKYGLIPIGYPPQAAIDELFRANSLKNTLVALHRESRENWDDARRSASILYSEKMDELDKKNEDITEAFNG 
               
               
                 LNKARMDEGTKDETGNKRLLAERAIINRLKKEKGDIYAELKPLRKEADKSIDKKALNDAYRQKCNDAVSAKVSGVY 
               
               
                 RRTAEQIYANFKTAKDKASKDNATLQFHRFDGTGYFQFRCNPKGVSTDGISVDAFMSANFDGYMRCAVQSVDNSKK 
               
               
                 KPRIRINAVLAGGRTKASKVFQEFDWIYHRPLPADAQIQNGKILRTRVGDKFRYDLVLTIRVPDVEMVQPAKLSGT 
               
               
                 IGIDVGFRKVGNTLLIGTVMSSDRSQKAVALEVPQMMVSALEHVVALQGELDDAASDLGKAITPLLKANPIDDEHS 
               
               
                 KYRLWRSLALRPLHVTLSFEQAYKLSLWLKHEPSLFPSEINLKVHTWWRSYSRKYREIHNRRKKQLTHRKHFYRET 
               
               
                 AAKLVAENKLIVLEDINLTDFAETKSKNTKLSNKARAQRFMASLGEFRDAIKNAAGREGVPVIDVNPAYTSKTCSD 
               
               
                 CGHLNKELRSEKEWTCPACGVVHDRDENAANNLQKMGQKYLLDVQKAASMVVQ (SEQ ID NO: 11) 
               
               
                   
               
               
                 &gt;3300009436|Ga0115008_10017733_3 
               
               
                 [aquatic-marine] 
               
               
                 MTTRVYKYGLIPIGYPPQVAIDELFRANNLWNTLVALHRESRENWDDARRSASILYSEKMDELDKKNKDIREAFNG 
               
               
                 LNQARMDEGTKDETGNKRLQAERAIINRLTKEQKEIYAELNPLRKEADKTVDKKALNDEYRKKCNTAVSAKVSGVY 
               
               
                 SRTAGELYAYFRTARDKAFKDKTTLRFHRFDGTGYFAFRCRSKAVGVNVDGISVEDFMSQGFMDYMRCAVMSIDES 
               
               
                 KKKPRILISAVLTGGATKASKVVQEFDWIYHRPLPPEGQIQNGKILRTRVGDKFKYDLVLTVKLPDVEMIQPAALN 
               
               
                 GTIGIDVGFRKVGNSLLIGTVMFSDSAQKAVALEVPTMVVSALEHVDALRSELDDVASDLGKAITPLLKANPIDEE 
               
               
                 HDKYRLWRSLALRPLHVTLSFEQAYKLALWLKREPNLFPSEINEKVHTWWRSYSRKYREIHNRRKKQLTHRKHFYR 
               
               
                 ETAAKLIAQNKLIVLEKIDLTDFAETKNKNTKLSNKARSQRFMAALGEFRDAIKNAADREGVPVIDVNAAYTSKTC 
               
               
                 SECGYLNKELKSEKEWNCPECGVVHDRDENAANNLQKMGQKYLLDAAKTAVVVVK (SEQ ID NO: 12) 
               
               
                   
               
               
                 &gt;3300009436|Ga0115008_10017733_4 
               
               
                 [aquatic-marine] 
               
               
                 MAIDELFRANNLWNTLVALHRESRENWDDARRSASILYSEKMDELDKKNKDIREAFNGLNQARMDEGTKDETGNKR 
               
               
                 LQAERAIINRLTKEQKEIYAELNPLRKEADKTVDKKALNDEYRKKCNTAVSAKVSGVYSRTAGELYAYFRTARDKA 
               
               
                 FKDKTTLRFHRFDGTGYFAFRCRSKAVGVNVDGISVEDFMSQGFMDYMRCAVMSIDESKKKPRILISAVLTGGATK 
               
               
                 ASKVVQEFDWIYHRPLPPEGQIQNGKILRTRVGDKFKYDLVLTVKLPDVEMIQPAALNGTIGIDVGFRKVGNSLLI 
               
               
                 GTVMFSDSAQKAVALEVPTMVVSALEHVDALRSELDDVASDLGKAITPLLKANPIDEEHDKYRLWRSLALRPLHVT 
               
               
                 LSFEQAYKLALWLKREPNLFPSEINEKVHTWWRSYSRKYREIHNRRKKQLTHRKHFYRETAAKLIAQNKLIVLEKI 
               
               
                 DLTDFAETKNKNTKLSNKARSQRFMAALGEFRDAIKNAADREGVPVIDVNAAYTSKTCSECGYLNKELKSEKEWNC 
               
               
                 PECGVVHDRDENAANNLQKMGQKYLLDAAKTAVVVVK (SEQ ID NO: 13) 
               
               
                   
               
               
                 &gt;3300001351|JGI20153J14318_10007490_6 
               
               
                 [aquatic-marine-pelagic marine] 
               
               
                 MATRVYKYGLIPIGYPPKETIDELFKANVLWNNLVALHRKNREDWDDARRAASILYSDKIDELEKKEEDLDAAWKA 
               
               
                 FQQARMDEGTRDETNNKRLKSERASINRLKAERAEIYKELKPLRKEADKEIDKKQLNDSFRAQVNEALSVNNSGVY 
               
               
                 RAIADQIYENFKTAKDKSIKENATLRFHRFDGTGYYHFRCRRKGTNVDGISIDDFMSRNFEAYPRCAVQNIDNSKK 
               
               
                 KPRIRINAVLAGGKSKASKIHQEFDLIYHRPLPIDAQIQNGKILRTRVGDKFKYDLVLTLKIPDKEPISYNNLKGT 
               
               
                 IGIDIGFRRSVNSLLIGTVMSSDVTEEAYEIIVPPKIVEAFEHVIDLQSELDDAATDLGRIITPLLKAHPLDEDHS 
               
               
                 KYKMWRSLALRPAHVTLSFEQAYKLAIWLKHEPDTFPEEITKKVHTWWRSYSRKYRELHNRRRNQLTHRKHFYREE 
               
               
                 AAKIVALNKLIVLEEINLTDFAETKEKNTKLSKKARAQRFMASLSEFRDAIKNAAQRDGIGIIDVNPAYTSKTCSE 
               
               
                 CGNLNKDLRSEKQWSCPACGVVHDRDENAANNLQKMGQSYLENIKKETSEIIE (SEQ ID NO: 14) 
               
               
                   
               
               
                 &gt;3300009447|Ga0115560_1022222_2 
               
               
                 [aquatic-marine-pelagic marine] 
               
               
                 MATRVYKYGLIPIGYPPKETIDELFKANVLWNNLVALHRKNREDWDDARRAASILYSDKIDELEKKEEDLDAAWKA 
               
               
                 FQQARMDEGTRDETNNKRLKSERASINRLKAERAEIYKELKPLRKEADKEIDKKQLNDSYRAQVNEAISVRNSGIY 
               
               
                 NATAGQVLDNFKAARDRSFKENATLKFHRFDGTGYYHFRCRRRGAKVDGINVEDFMSRNFIANPRCAVQSIDNSKK 
               
               
                 KPRIRINAVLAGGQSKASKVHQEFDLIYHRPLPIDAQIQNGKILRTRVGDKFKYDLVLTLKIPDKEPISYNNLKGT 
               
               
                 IGIDIGFRRSVNSLLIGTVMSSNVSEKAYEIKVPPKIVEAFEHVIDLKSELDDAATDLGRIITPLMKAHPLDEDHS 
               
               
                 KYKMWRSLALRPAHVTLSFEQAYKLAIWLKHEPDTFPEEITKKVHTWWRSYSRKYRELHNRRRNQLTHRKHFYREE 
               
               
                 AAKIVALNKLIVLEEINLTDFAETKEKNTKLSKKARAQRFMASLSEFRDAIKNAAQRDGIGIIDVNPAYTSKTCSE 
               
               
                 CGNLNKDLRSEKQWSCPACGVVHDRDENAANNLQKMGQTYLESLKKETSEVIE (SEQ ID NO: 15) 
               
               
                   
               
               
                 &gt;3300009505|Ga0115564_10016546_3 
               
               
                 [aquatic-marine-pelagic marine] 
               
               
                 MATRVYKYGLIPIGYPAKETIDELFKANVLWNNLVALHRKNREDWDDARRAASVLYSDKIDDLEKKEEDLDAAWKA 
               
               
                 FQQARMDEGTRDETNNKRLKSERASINRLDTEKAEIYKELKPLRKEADKEIDKKQLNDAYRTKVNEAVSVRNSGIY 
               
               
                 SATAGQILENFKTARDRSFKESATTLRFHRFDGTGYYQFRCRRKGTNVDGISIDDFMSRNFEANPRCAVQSIDNRK 
               
               
                 KKPRIRIDAVLVGGQSKASKIHQEFDLIYHRPLPIDAQIQNGKILRTRVGDKFKYDLVLTLKIPDKEPISYNNLKG 
               
               
                 TVGIDIGFRRSVNSLLIGTVMSSDVTEKAYEIKVPPKIVEAFEHVIDLQSELDDAATDLGRIITPLLKAHPLDEDH 
               
               
                 NKYKMWRSLALRPAHVTLSFEQAYKLAIWLKHETDTFPEEITKKVHTWWRSYSRKYRELHNRRRNQLTHRKHFYRE 
               
               
                 EAAKIVALNKLIVLEEINLTDFAETKEKNTKLSKKARAQRFMASLSEFRDAIRNAAQRDGIGIIDVNPAYTSKTCS 
               
               
                 ECGNLNKDLKSEKQWSCPACGVVHDRDENAANNLQKMGQTYLESLKKETSEVIE (SEQ ID NO: 16) 
               
               
                   
               
               
                 &gt;3300020165|Ga0206125_10004811_3 
               
               
                 [aquatic-marine-seawater] 
               
               
                 MWCEINMATRVYKYGLIPIGYPPKETIDELFKANVLWNNLVALHRKNREDWDDARRAASILYSDKIDELEKKEEDL 
               
               
                 DAAWKAFQQARMDEGTRDETNNKRLKSGRASINRLDAEKAEIYKELKPLRKEADKEIDKKQLNDAYRTKVNEAVSV 
               
               
                 RNSGIYSATAGQILENFKTARDRSFKESATTLRFHRFDGTGYYQFRCRRKGTNVDGISIDDFMSRNFEANPRCAVQ 
               
               
                 SIDNSKKKPRIRIDAVLVGGQSKASKIHQEFDLIYHRPLPIDAQIQNGKILRTRVGDKFKYDLVLTLKIPDKEPIS 
               
               
                 YNNLKGTIGIDIGFRRSVNSLLIGTVMSSDVTEKAYEIKVPPKIVEAFVHVIDLQSELDDAATDLGRIITPLLKAH 
               
               
                 PLDENHSKYKMWRSLALRPAHVTLSFEQAYKLAIWLKHEPDTFPEEITKQVHTWWRSYSRKYRELHNRRRNQLTHR 
               
               
                 KHFYREEAAKIVALNKLIVLEEINLTDFAETKEKNTKLSKKARAQRFMASLSEFRDAIRNAAQRDGIGIIDVNPAY 
               
               
                 TSKTCSECGNLNKGLRSEKQWSCPACGVVHDRDENAANNLQKMGQSYLESVKKETSEVIE (SEQ ID NO: 17) 
               
               
                   
               
               
                 &gt;3300010313|Ga0116211_1004493_2 
               
               
                 [aquatic-thermal springs-hot spring] 
               
               
                 MIKAFKYGMLEPVAGFDKAAIDVLYLRNKLWNSLVELEKAHRERYRTLITGSDDELSKIQARLDQIEAERAELVKR 
               
               
                 KRQARAMVRSKKVDTSEHDDRIDMLMAERNDLRTKAKDIRLQVKEKVKPAIADLEKERYEAVKHLIHEAGLWWCNS 
               
               
                 ETVIAAYDLARVKAMKENAELRFRSFDGSGKFAVRKTGGFALSDLVSGKLSFARLEALPDANFAHLSERGKRSRAR 
               
               
                 HHLTMTILTYKDESGKLCRHEVTWPIILHRPLPPEGMIKFIHVQRKRIGKDFQWTCSITMEVDEIQKTPIDHPSRA 
               
               
                 ACGIDIGYRLVKDGLRVAVIADTSGKIDHLTLPQDWIEKMDHVESIQGHLDNSNDLAWGELKALLKSMHDYPESIA 
               
               
                 ESIGRLLKAGDRTPVRGMRALHWRLRNEPETMPEVLSILDTWEAETCRREREMHRLRRKLINRRKDLYRNFAYKVA 
               
               
                 NRYVLIRIRGLSLKKLAAVNLEDGSDNQMPQAVRNNRTRASLSELTLCLQQAAVKAGADFEKVFDVNSTTTCSTCG 
               
               
                 NQNLKMDREDIYFRCEKCDTLHDQDENAAKNLLRKEFYLAEQAVM (SEQ ID NO: 18) 
               
               
                   
               
               
                 &gt;3300009784 Ga0123357_10002363_9 
               
               
                 [arthropoda-digestive system-termite gut] 
               
               
                 MENHKFTIPDQANQGIIVYEYGIRLDKESKPLVWQQIQLSRKLYNNIVASMRQTFDAMNTFILERAGDEGKQLNQA 
               
               
                 IEEGIERFKTAKAEQNEDDIKETVLFLREKRAKLSEQLKGVRTQYKEETKRNFFNRIGMRTSCETYQIRSQAVKDG 
               
               
                 LGWATANEVLNSALKAFQARIKTGQPPKFAVGEEKQQDSLRTQFTQAGGCPVATLFESEHSGLSLRAAAGFGRRKY 
               
               
                 GTFRFRLGEAKSDVWATGTCQFHREIPSGATVASAALVQRRIGRDLKHALQLVVKLPQQAEAQATQSKKFCTVHFG 
               
               
                 WASEEGIQYVMALADQENPTKAQLFQLPTDIETDFNRVENLASQRSKLLNDLVLQIKSGSIVIPSQIKEVADEFDA 
               
               
                 IKRLPATHISLTRLHRICRLMIESDIFRPEALERWRRQDRLLLQDIAHIRRRALYRRRDFYRVTASVIAKSYGAIV 
               
               
                 IETLDLKKANTKINMVTGEKSDKNKKSRSRQRMAALHELQRQLRQAAGKAGCVIIELTGEKTTATCAFCNREGTTT 
               
               
                 TSESSQVLHCPHCGSQMNRKQNGAAVAWQLASPIIDDLVHEARSLAAVQSSERAASKILKAEKVATARKANRAARE 
               
               
                 PAATDK (SEQ ID NO: 19) 
               
               
                   
               
               
                 &gt;ADIG01000806_20 
               
               
                 [groundwater metagenome] 
               
               
                 MIVQITPAPLPQGDVRIYEFGARLDHDCVRTVDEQIFKAHQLYNQLVACMQTTVRDMQAYLLDHAGPDAHAAKARV 
               
               
                 DGLNEAFNAARAANDENRMTTVATERREAWRALAAVLRIARKEHRTAMQETFLSRIGKKSACETYQLRCKAVADGL 
               
               
                 GWATANATLDAALIAFKKSFALGRAPRFARIADSIQDTLTLQFTAAGGINIERLLDGKHTELALKPPAVCGKRGYG 
               
               
                 TFAFRLGAASAETQATGTWQYHRPLPPGGTVGLARLVRRRIGPKTTWSLQLQVRSPLPEREHEDRRPLVTVHPGWA 
               
               
                 ADLSGRRIAGIADAADPGLATVLQLPPDIEHGLQRAAELESTRSQARDALTPMLKVHPWPQELLNAATPEEDASAS 
               
               
                 GDSGPMAPERIMCRKVADEILALRRLPAQHIAIRRLHRLARWLRLAEVDVPDWLETWRKEDKLRWQASAAAAKRAR 
               
               
                 NRRRGFYRETALRLASQYQAIVIEPLNLADAAKKIDEATGERSDFAKKARAGRVVAAIFELDSAIRWAATKCGTAV 
               
               
                 LDLTGETAQHCAICGGHSLKADDEDSQCLRCSDCGADIDRKRNGAALAWQAAAAHLETHLEDFWRLTLENRASAAA 
               
               
                 KRDEKKTKLQEGRRAAMRETLET (SEQ ID NO: 20) 
               
               
                   
               
               
                 &gt;CXWL01128655_18 
               
               
                 [groundwater metagenome] 
               
               
                 MIKAYKFGLLNPISGFDQAAMDVLYLRNKLWNQLVELEKNSRAAYRALMLDSSEELSVIQTRIDAIEVERADLVSQ 
               
               
                 KKKLRASVRSKKVDTAGIDAAVERLIAERTNLRAKAKQLREVVKVEIKPKAVELDKVRYAAVLALIKGSGLWWGNS 
               
               
                 ETVIAAYDVARVRAMKESAELRFRSFDGTGKFAYRESGGIDFDKFMSGKVNFARLNTLPDSDFAHLSERGRRSKAR 
               
               
                 HHLTMTVLTSVDDAGKKVRHEVTWPIVMHRDMPAGAIKTIHVHRKRVGDQFNWTCSITIDVPEEPKQLIDHPAKAA 
               
               
                 CGIDLGFRLVKDGLRIATIADSDNRIEHVVLPLDWIEKMDYVEHLQSTLSETANLTWVRLRKHLSELPDYPESIKE 
               
               
                 RIHNILKAGERVPTRGMRSLLGALKAEPELLPEALQILAAWSDDIYRPAREMHNLRDKLMKRRQDLYRNVSHCLSN 
               
               
                 KYAMVRVEDMDLRQIARVKKDDGSDNPLPDTVRDNRKRAALFEFVLSIKQSCVKTGSVFEKMNPAYSSMTCSSCGH 
               
               
                 LNQPGMDIHYSCENCGTLHDQDENAAKNFLRGEYFSSPKQDVA (SEQ ID NO: 21) 
               
               
                   
               
               
                 &gt;OGCL01001770_13 
               
               
                 [hot springs metagenome] 
               
               
                 MIKAFKYGMLEPVAGFDKAAIDVLYLRNKLWNSLVELEKAHRERYRTLITGSDDELSKIQARLDQIEAERAELVKR 
               
               
                 KRQARAMVRSKKVDTSEHDDRIDMLMAERNDLRTKAKDIRLQVKEKVKPAIADLEKERYEAVKHLIHEAGLWWCNS 
               
               
                 ETVIAAYDLARVKAMKENAELRFRSFDGSGKFAVRKTGGFALSDLVSGKLSFARLEALPDANFAHLSERGKRSRAR 
               
               
                 HHLTMTILTYKDESGKLCRHEVTWPIILHRPLPPEGMIKFIHVQRKRIGKDFQWTCSITMEVDEIQKTPIDHPSRA 
               
               
                 ACGIDIGYRLVKDGLRVAVIADTSGKIDHLTLPQDWIEKMDHVESIQGHLDNSNDLAWGELKALLKSMHDYPESIA 
               
               
                 ESIGRLLKAGDRTPVRGMRALHWRLRNEPETMPEVLSILDTWEAETCRREREMHRLRRKLINRRKDLYRNFAYKVA 
               
               
                 NRYVLIRIRGLSLKKLAAVNLEDGSDNQMPQAVRNNRTRASLSELTLCLQQAAVKAGADFEKVFDVNSTTTCSTCG 
               
               
                 NQNLKMDREDIYFRCEKCDTLHDQDENAAKNLLRKEFYLAEQAVM (SEQ ID NO: 18) 
               
               
                   
               
               
                 &gt;LNAP01002847_16 
               
               
                 [soil metagenome] 
               
               
                 MKKITIRKYGARLLGDSEPIIVKSMRDQNTLWNKLVEIERANTTEYRDIVAQSDDVLAALTQEYAAAEQRLKDVQE 
               
               
                 MRNRVRAAKRSKQIEGAENYAAEIKAISSSLKDLRARMKECRARAKEAAKPRLEGLEDRRRAAVKQATNEAAIWWA 
               
               
                 HSELVTNSFDVARVKALKSNAELRFHRFEGEGRIGVRIQDGILLGNQKGTSMLQVREATPEELGHLQAQRARKRLV 
               
               
                 AVDIRVGKRGEDGHIPKATFLVTIHEGMELLPNTPLKTVTVKREMHAGQPKWFMVFMFVESDAEPEDKPLPPKAVG 
               
               
                 VDFGWRVVKDREWGERTGLRVATIANKDGTKQHITLPPELLARFERSTRLRSELDVAANEFWVRTASLFTDDILAT 
               
               
                 LSEDEWLRVLVGKAKRAHRPYPSLMEAITRAHAANPVLGPEADEQMQAWARRARRLNVAAFGARRKAADHRKHLYR 
               
               
                 NVAARLVRECGLIAIKDTDFHKLAKLVDDDGKETELNKHARANRFMASPSELRQAIKMAALREQRELVNVAPAHTT 
               
               
                 TTCSACGHVHGERPKDLIFVCDSCGKWHDQDENSAAICLKIALESKL (SEQ ID NO: 22) 
               
               
                   
               
               
                 &gt;3300007533|Ga0102944_1000048_72 
               
               
                 [terrestrial-soil-pond soil] 
               
               
                 MNDVTLSFRGLEPRESTSWSYGARVAGSEALEEQYTLAQRTYNNMVEVTRQALAAFNEWFAEKDPEIARLGTEIER 
               
               
                 LGAQWAEAKARDDRDELARIAAERRPLRQQWYERCFAVRKDNRGEVNALLKQWVGSAKESRLYLARVEAVKAGLYW 
               
               
                 ATATAVMTAVQRAWDKQFPRLRPVAFSRRSEKRRETLVVQFTESGGVAMETLHTKHGGLWIEPPGEGLLSAWANGR 
               
               
                 RPGRPDRYLRFRMRIGGRGREGVYVEGSVOMVRPVPEGARVMMARLVRERVATRYRYQLQLVLRLAEPLSIPAEDK 
               
               
                 APRVALDIGWYYEAGRGRRVIAYTAGANEDAVEQIYLDPSIDEAFDRVDDMNSRRSLARDDVTIALRCCQWDGAPE 
               
               
                 ALAEALSAINRLPVAHVSPARLAQMVWLWREHHGDYRPDVLEELWAWRRWDKKLYETSAHLRRRTAGRRKKFYEGW 
               
               
                 ARHFASRYATIVVVRPDLREAAMVKNAISGEHTALTARARQGRVRAALYEFLNVVATKAAEAGSVVIELTGRTTTE 
               
               
                 CSACGEIMVVPEDNPATRLLVCHACGVSHDREANSAVLAFRVLDDEASVTKGLAHAQEKADKARERRYKRRTAMRD 
               
               
                 ARWKDEQTTTSGQ (SEQ ID NO: 23) 
               
               
                   
               
               
                 &gt;3300007533|Ga0102944_1003721_10 
               
               
                 [terrestrial-soil-pond soil] 
               
               
                 MNQSPPANGECMENVTLSFRGLEPRESTSWNYGARVEASEALEEQFTLAHRTYNQMVEVTRHALAALTDWFCEKDP 
               
               
                 EIARLGAAIERLSAQWSEAKARDARDELEQIAAERRFLRKDWYERCFAVRKDNRSEVNALIRQWVGLTKESRLYAV 
               
               
                 RTEAVKAGLYWASATAVMTAVQQAWDKQFPRLRPVAFSKRAEKTRETLVVQFTEAGGVPMSTLHSKHGGLWIEPPG 
               
               
                 DGLLTAWANGRRPARPDRYLRFRMRIGGRGREGVYVEGSVQMVRPVPEGARVMMARLVRERVATKYRHQLQLVLRL 
               
               
                 AEPLSIPTETKEPRVALDLGWYYEAGLGRRVIAYTGGDNEDAVEQIYLPPGIDEAFDRVDDMNSRRSLARDDVAIT 
               
               
                 LRCCQWDDAPAPLAETLAAINKAPVAHVAQARLARLVWQWRNEHSDYRPDVLAELWSWRRWDKKLYEASAHLRRRT 
               
               
                 AGQRKKFYEHWARYFASRYTTIVVVRPALREAAVIKNEASGEHTALTARARQGRVRAALYDFLNAVATKAAETGSV 
               
               
                 VIEVSGRTTTECSACGAIMAVPEENPATRTLVCHACGVSHDREANSAVLAYRVPDDDGAVTQSLEHAQEQADRARE 
               
               
                 RRERRRQAMREGRWKGKQSAGGGD (SEQ ID NO: 24) 
               
               
                   
               
               
                 &gt;3300007533|Ga0102944_1003721_8 
               
               
                 [terrestrial-soil-pond soil] 
               
               
                 MENVTLSFRGLEPRESTSWNYGARVEASEALEEQFTLAHRTYNQMVEVTRHALAALTDWFCEKDPEIARLGAAIER 
               
               
                 LSAQWSEAKARDARDELEQIAAERRFLRKDWYERCFAVRKDNRSEVNALIRQWVGLTKESRLYAVRTEAVKAGLYW 
               
               
                 ASATAVMTAVQQAWDKQFPRLRPVAFSKRAEKTRETLVVQFTEAGGVPMSTLHSKHGGLWIEPPGDGLLTAWANGR 
               
               
                 RPARPDRYLRFRMRIGGRGREGVYVEGSVQMVRPVPEGARVMMARLVRERVATKYRHQLQLVLRLAEPLSIPTETK 
               
               
                 EPRVALDLGWYYEAGLGRRVIAYTGGDNEDAVEQIYLPPGIDEAFDRVDDMNSRRSLARDDVAITLRCCQWDDAPA 
               
               
                 PLAETLAAINKAPVAHVAQARLARLVWQWRNEHSDYRPDVLAELWSWRRWDKKLYEASAHLRRRTAGQRKKFYEHW 
               
               
                 ARYFASRYTTIVVVRPALREAAVIKNEASGEHTALTARARQGRVRAALYDFLNAVATKAAETGSVVIEVSGRTTTE 
               
               
                 CSACGAIMAVPEENPATRTLVCHACGVSHDREANSAVLAYRVPDDDGAVTQSLEHAQEQADRARERRERRRQAMRE 
               
               
                 GRWKGKQSAGGGD (SEQ ID NO: 25) 
               
               
                   
               
               
                 &gt;APMI01033782_24 
               
               
                 [wastewater metagenome] 
               
               
                 MKSTPDTISITPGATANGDMLTYEYGLRLDKESIAHVGAQIAMSRRLYNDLVAQIRTTVDALQAFVIDKAGDEAVQ 
               
               
                 IKVRIEELTTNFKAAKAEDNEPEMKRIAEDRRNQWKLLSALIKAASKANRAEINERFLSKIGKNSSCPTYQLRGKA 
               
               
                 VAEGLGWGTANAVLDAALQAFKTSFALGRAPRFASGAEIDQDCLFLQFTAAGGVASASLLAGKQADLQLLPTNGCG 
               
               
                 KRKYGEFKFRLGAAKADTYATGTWQYHRPLPDGSNIALARLVRRRIGMHDKWAIQLLVKPKTPIRESVEERKPLVA 
               
               
                 VHFGWAADIAGRRVAAIADAADPGAATILALPPSIEEALDRAREIQGVRDKSRDEIAPQVRSIEIPGSANETLIDL 
               
               
                 LGRVRKTRPQDISANRIHYLCRLLREADHLPDWLEAWRKEDKNRWQDQAHIAKRARNARKSFYREVAINLGRQYDA 
               
               
                 IAIEPLDLASAAMKVNEATGEKTDFAKKARAGRVVAALYEFESAIRWAATKTAAALIEVSGATASVCSVCGGHVEA 
               
               
                 TKDDHQSIVCHDCGAVLDRKQNGAAIAWQSANDKREDVVTEFWSEYFADSEAKKEKKAEKLAKMAEGRRNARTESA 
               
               
                 AEIA (SEQ ID NO: 26) 
               
               
                   
               
               
                 &gt;NZ_JQKL01000024_23 
               
               
                 [ Clostridiales bacterium  DRI-13] 
               
               
                 METAATKNYLALSFGCLSPTRGEEYLLDQIKKKHDLWNKLVEKDREHREKVRQVMVFESETTKKIKELEEELNSLR 
               
               
                 EEIKNQRKTKRTGKVDLTDQKARIEEIKPQLKQLKEKFKEERSFIFEARKQELAQLEKERWAVVKELGKGSGLYWC 
               
               
                 NLEDVVNSYDIGRKKAKAAGGEMRFHRWDGTGKVTVRFQKGLPVNEMFSCTNNLLQIDPVDKDAWYNPVRAIRRKK 
               
               
                 SRTRVRLRACSENKKPLFIELPVVLHREIPEDALIRTASVIREKVGMRYRYKLNLVLEILGENTNRILPALEGTAA 
               
               
                 IDLGWRTVKDGLRVACLVDDKGHSEELILDNDVLHEFNKIKDLQSIRDNLFNETKAKLMELLKTLELPDEAKERTS 
               
               
                 HMANWRSQQKMLRLHQYWRENRLPGDDEVWEVLEYWRKREIHLYEWQENLRDQVLRRRKEIYRIFAAKITRKYKTI 
               
               
                 VLEEFTLNKTVQKPNPEEGPAGTLPANRNRFIAAISEFRNELANACRKNHVEFTYVPAENTTITCHKCGHKEKFDA 
               
               
                 AAQIIHTCSTCGELWDQDYNAAKNLLAFSQKGGVK (SEQ ID NO: 48) 
               
               
                   
               
               
                 &gt;WP_081908191.1 
               
               
                 [ Clostridiales bacterium  DRI-13] 
               
               
                 MSRLEARTRYLQAGQKRLGKIRKRGFFMETAATKNYLALSFGCLSPTRGEEYLLDQIKKKHDLWNKLVEKDREHRE 
               
               
                 KVRQVMVFESETTKKIKELEEELNSLREEIKNQRKTKRTGKVDLTDQKARIEEIKPQLKQLKEKFKEERSFIFEAR 
               
               
                 KQELAQLEKERWAVVKELGKGSGLYWCNLEDVVNSYDIGRKKAKAAGGEMRFHRWDGTGKVTVRFQKGLPVNEMFS 
               
               
                 CTNNLLQIDPVDKDAWYNPVRAIRRKKSRTRVRLRACSENKKPLFIELPVVLHREIPEDALIRTASVIREKVGMRY 
               
               
                 RYKLNLVLEILGENTNRILPALEGTAAIDLGWRTVKDGLRVACLVDDKGHSEELILDNDVLHEFNKIKDLQSIRDN 
               
               
                 LFNETKAKLMELLKTLELPDEAKERTSHMANWRSQQKMLRLHQYWRENRLPGDDEVWEVLEYWRKREIHLYEWQEN 
               
               
                 LRDQVLRRRKEIYRIFAAKITRKYKTIVLEEFTLNKTVQKPNPEEGPAGTLPANRNRFIAAISEFRNELANACRKN 
               
               
                 HVEFTYVPAENTTITCHKCGHKEKFDAAAQIIHTCSTCGELWDQDYNAAKNLLAFSQKGGVK (SEQ ID NO: 
               
               
                 49) 
               
               
                   
               
               
                 &gt;GAB36148.1 
               
               
                 [ Gordonia otitidis  NBRC 100426] 
               
               
                 MTRVTVQTAGVHYKWQMPDQLTQQLRLAHDLREDLVTLEYEYEDAVKAVWSSYPAVAALEAQVAELDERASELAST 
               
               
                 VKEEKSRQRTKRPSHPAVAQLAETRAQLKAAKASRREAIASVRDEATERLRTISDERYAAQKQLYRDYCTDGLLYW 
               
               
                 ATFNAVLDHHKTAVKRIAAHRKQGRAAQLRHHRWDGTGTISVQLQRQATDPARTPAIIADADTGKWRSSLIVPWVN 
               
               
                 PDVWDTMDRASRRKAGRVVIRMRCGSSRNPDGTKTSEWIDVPVQQHRMLPADADITAAQLTVRREGADLRATIGIT 
               
               
                 AKIPDQGEVDEGPTIAVHLGWRSSDHGTVVATWRSTEPLDIPETLRGVITTQSAERTVGSIVVPHRIEQRVHHHAT 
               
               
                 VASHRDLAVDSIRDTLVAWLTEHGPQPHPYDGDPITAASVQRWKAPRRFAWLALQWRDTPPPEGADIAETLEAWRR 
               
               
                 ADKKLWLESEHGRGRALRHRTDLHRQVAAYFAGVAGRIVVDDSDIAQIAGTAKHSELLTDVDRQIARRRAIAAPGM 
               
               
                 LRAAIVAAATRDEVPTTTVSHTGLSRVHAACGHENPADDRYLMQPVLCDGCGRTYDTDLSATILMLQRASAATSN 
               
               
                 (SEQ ID NO: 50) 
               
               
                   
               
               
                 &gt;BAFB01000202_4 
               
               
                 [ Gordonia otitidis  NBRC 100426] 
               
               
                 MPDQLTQQLRLAHDLREDLVTLEYEYEDAVKAVWSSYPAVAALEAQVAELDERASELASTVKEEKSRQRTKRPSHP 
               
               
                 AVAQLAETRAQLKAAKASRREAIASVRDEATERLRTISDERYAAQKQLYRDYCTDGLLYWATFNAVLDHHKTAVKR 
               
               
                 IAAHRKQGRAAQLRHHRWDGTGTISVQLQRQATDPARTPAIIADADTGKWRSSLIVPWVNPDVWDTMDRASRRKAG 
               
               
                 RVVIRMRCGSSRNPDGTKTSEWIDVPVQQHRMLPADADITAAQLTVRREGADLRATIGITAKIPDQGEVDEGPTIA 
               
               
                 VHLGWRSSDHGTVVATWRSTEPLDIPETLRGVITTQSAERTVGSIVVPHRIEQRVHHHATVASHRDLAVDSIRDTL 
               
               
                 VAWLTEHGPQPHPYDGDPITAASVQRWKAPRRFAWLALQWRDTPPPEGADIAETLEAWRRADKKLWLESEHGRGRA 
               
               
                 LRHRTDLHRQVAAYFAGVAGRIVVDDSDIAQIAGTAKHSELLTDVDRQIARRRAIAAPGMLRAAIVAAATRDEVPT 
               
               
                 TTVSHTGLSRVHAACGHENPADDRYLMQPVLCDGCGRTYDTDLSATILMLQRASAATSN (SEQ ID NO: 51) 
               
               
                   
               
               
                 &gt;WP_039994403.1 
               
               
                 [ Gordonia otitidis  NBRC 100426] 
               
               
                 MHYKWQMPDQLTQQLRLAHDLREDLVTLEYEYEDAVKAVWSSYPAVAALEAQVAELDERASELASTVKEEKSRQRT 
               
               
                 KRPSHPAVAQLAETRAQLKAAKASRREAIASVRDEATERLRTISDERYAAQKQLYRDYCTDGLLYWATFNAVLDHH 
               
               
                 KTAVKRIAAHRKQGRAAQLRHHRWDGTGTISVQLQRQATDPARTPAIIADADTGKWRSSLIVPWVNPDVWDTMDRA 
               
               
                 SRRKAGRVVIRMRCGSSRNPDGTKTSEWIDVPVQQHRMLPADADITAAQLTVRREGADLRATIGITAKIPDQGEVD 
               
               
                 EGPTIAVHLGWRSSDHGTVVATWRSTEPLDIPETLRGVITTQSAERTVGSIVVPHRIEQRVHHHATVASHRDLAVD 
               
               
                 SIRDTLVAWLTEHGPQPHPYDGDPITAASVQRWKAPRRFAWLALQWRDTPPPEGADIAETLEAWRRADKKLWLESE 
               
               
                 HGRGRALRHRTDLHRQVAAYFAGVAGRIVVDDSDIAQIAGTAKHSELLTDVDRQIARRRAIAAPGMLRAAIVAAAT 
               
               
                 RDEVPTTTVSHTGLSRVHAACGHENPADDRYLMQPVLCDGCGRTYDTDLSATILMLQRASAATSN (SEQ ID 
               
               
                 NO: 52) 
               
               
                   
               
               
                 &gt;WP_013159911.1 
               
               
                 [ Meiothermus silvanus  DSM 9946] 
               
               
                 MPFGKKARHVKAYQFGADAPQEGMEAVLEQHRLRTDYYNALVEMELRQREERTALLANLAAESGLESPNQVYERLK 
               
               
                 AAGEKGIRKHPEYVAARERQKALYGHPRLLELQSRQREERNALRRSFGAKGLYSSNYLDVERAFDKARQSPELRFR 
               
               
                 RYSPHEGRLAVLYTEGLPMREIGSDTRVQLPLPDPIIYRDRATRRKHQRVLMKFRVRSVERQPLWITVPVYLHREL 
               
               
                 PDGVCREVSLHWHRVADRLRWTVSVVVEVEGPPVASPTGRGAVAVDLGWRRVEGGLRAGFWVGEDGAGGEIALSEG 
               
               
                 DLKQFSKVEDLRSIRDQHLNALKEALAAWLEAPPAPLPDWLAEETKTLPQWRSPARFAALFRRWQSERVHADEAAY 
               
               
                 GLLEGWHKRDRHLWQYEANLREQMILRRREQYRVLAATLARQYDALIVEDFNLRAAAELDQGGSDLPDAARRYRTI 
               
               
                 ASPSTLRDALVNAFAQRGKPVRKLNPAHTTTDCHACGGALVGDPAKELRLYCPTCERFYDQDENAARNLLRRAQEV 
               
               
                 QAQV (SEQ ID NO: 53) 
               
               
                   
               
               
                 &gt;WP_096876841.1 
               
               
                 [ Methylomonas   koyamae ] 
               
               
                 MIRTYKYSLKAPENFAEDCEDELRRMNDLWNRLIEIDRQRERSFKDLCRSTSAEYAAAQDEIEALREPIDNLYDAI 
               
               
                 RAERIATRSKEPSDELRARRDELLGRRKALWEICKAIQKAIPKESQAPINEVYKTNVKLARQQSGCFWGNYNAVIE 
               
               
                 SFETAKSKAIKDGGRLHFKSFDGSGRFVNQIQGGMTVTELLAGSHSQAQLTNLVTTNKTKGRFAFTAFTGKDDAGK 
               
               
                 RFRRQLFSEINYHRPIPADGVIKAVEVVKVPHDGKQKYKWHACFTVALPEVDIKHPKRNIAGVNLGWRQFGGRLRV 
               
               
                 AVVVDDAGKKTEYFVPAELVSKFEAAETIQKAADDARNEMLSWLRTFYQDNRDEAPQEWRESIQGLLRNRPSVDAA 
               
               
                 NHLMTIWRECVFAQEESRRYAAWLKSDAALRRSYTGCRQNAVKWREEIYRHIAKELAERYAVLAVTDTPLSTMSRT 
               
               
                 KAKDDLAVDNALPESARRNRVIAAIYSLKEWIGKQAAKTGSTVETITGKMTATCHKCGYVAEKRLRGSQYATCKSC 
               
               
                 GSELELDENAAINCRNHASGAVLISDKPEKTGRFQRAKMAENDFARKIGDNASPLVT (SEQ ID NO: 54) 
               
               
                   
               
               
                 &gt;WP_048895525.1 
               
               
                 [ Mycobacterium   conceptionense ] 
               
               
                 MAITVHTAGVHYRWTDNPPEQLMRQLRLAHDLREDLVTLQLDYETAKAGIWSSYPAVAAAETELADAESAAEQAAA 
               
               
                 AVSEERTKLRTKRITGPLAQKLTAARKRVREARSTRRAAISEVHEEAKGRLVDASDALKAQQKALYKTYCQDGDLF 
               
               
                 WATFNDVLDHHKAAVKRIGQMRAAGQPAQLRHHRFDGTGSIAVQLQRQAGQPQRTPELIADVDGKYGRVLSVPWVQ 
               
               
                 PDRWERIPRRERRMIGRVTVRMRAGQLSGEPQWLDIPVQQHRMLPLDADITGARLTVTRTAGTLRAQISVTAKIPD 
               
               
                 PEPVTDGPDVAVHLGWRNTDTGVRVARWRSTEPIEVPFDFRDTLTVDPGGRSGEIFVPEAVPRRVERAHLIASHRA 
               
               
                 DRMNELRARLVDYLAETGPRPHPSREGEELGAGNVRMWKSPNRFAWLARVWADDESVSTDIREALAQWRHQDWISW 
               
               
                 HHQEGGRRRSAAQRLDVYRQVAAVLVSQAGRLVLDDTSYADIAQRSATTKTEELPNETAARINRRRAHAAPGELRQ 
               
               
                 TLVAAADRDAVPVDTVSHTGVSVVHAKCGHENPSDGRFMSVVVACDGCGEKYDQDESALTHMLTRAVQSAA (SEQ 
               
               
                 ID NO: 55) 
               
               
                   
               
               
                 &gt;WP_061006603.1 
               
               
                 [ Mycobacterium   mucogenicum ] 
               
               
                 MTTMTVHTMGVHYKWQIPEVLRQQLWLAHNLREDLVSLQLAYDDDLKAIWSSYPDVAQAEDTMAAAEADAVALSER 
               
               
                 VKQARIEARSKKISTELTQQLRDAKKRLKDARQARRDAIAVVKDDAAERRKARSDQLAADQKALYGQYCRDGDLYW 
               
               
                 ASFNTVLDHHKTAVKRIAAQRASGKPATLRHHRFDGSGTIAVQLQRQAGAPPRTPMVLADEAGKYRNVLHIPGWTD 
               
               
                 PDVWEQMTRSQCRQSGRVTVRMRCGSTDGQPQWIDLPVQVHRWLPADADITGAELVVTRVAGIYRAKLCVTARIGD 
               
               
                 TEPVTSGPTVALHLGWRSTEEGTAVATWRSDAPLDIPFGLRTVMRVDAAGTSGIIVVPATIERRLTRTENIASSRS 
               
               
                 LALDALRDKWGWLSDNDAPTYRDAPLETkATVKQWKSPQRFASLAHAWKDNGTEISDILWAWFSLDRKQWAQQENG 
               
               
                 RRKALGHRDDLYRQIAAVISDQAGHVLVDDTSVAELSARAMERTELPTEVQQKIDRRRDHAAPGGLRASVVAAMTR 
               
               
                 DGVPVTIVAAADFTRTHSRCGHVNPADDRYLSNPVRCDGCGAMYDQDRSFVTLMLRAATAPSNP (SEQ ID NO: 
               
               
                 56) 
               
               
                   
               
               
                 &gt;WP_011733919.1 
               
               
                 [ Pelobacter propionicus  DSM 2379] 
               
               
                 MKRVTITIDGEQTKGIVIGTIAANHTAAEWLLTASVSAKSAKVRFDPEEAVAETSSLVMIAPTRTEKYLYLVPDEQ 
               
               
                 VQPVTTIVRKYGLLSPLDWDCPDYPAGDAFEHLFLQNKLWNDLVTIEREHRAKYRELIGSDEETAQMDTEIASIKD 
               
               
                 RLSVLDEGRKKLRVEHRKKKCPEIDCLDENIKKLKSELKAVASKAKETRAAAKDRIRAAGNDIENLEKDRQAAVIK 
               
               
                 AYNNSGLWWGNYNAVLESYKKARIKALKDGAELKYHRFDGSGRFTNQIQGGMSVQDLLEGNRNVASLRLVSSGELG 
               
               
                 DISGKKPPSLDLQSVGSRRDSREYGILAITLYTGTDEQSKKFRRTLSFPVILHRPLPEGATLKSLSVHRKRVGTDF 
               
               
                 VWSVVFTFTTDCPTYDQRSSTGNRCGLNLGWKKQAGGGLRVATIYDGSDARHITLPQAIIDGLDYVNGDLQGRIDS 
               
               
                 AANENHAWLLEQWGGDELPESLQELRSMLRRSKRPHPAKFAKAVIAWRNYPEYLGDARDEAEQRRKATKRLTIEMA 
               
               
                 HKREKLLRRRMDFYRNTAKQLTSVYDVICLDKMDLRRLALLEKGDGTPNELTKIARKQRQQAAISELRECLSKAAA 
               
               
                 KNGTQIEQVSTASSATCSACKGKMEQVDGIMWRCRECRALVDQDINAAANLFREVL (SEQ ID NO: 57) 
               
               
                   
               
               
                 &gt;WP_018234394.1 
               
               
                 [ Thioalkalivibrio thiocyanodenitrificans  ARhD 1] 
               
               
                 MKRQQEDTEALVYAYGARIPLDDPHLQEELRKQRAFWDALVEATLAAERELDDRMKADSPQYAAAVQALIDASQAV 
               
               
                 REAIERRNAERAKTRSRTTSVDGEVKERITEKNAARKEVWRLAGEWRKANKEAVSEHQARMKEEAKRLRQGCGLYW 
               
               
                 GNYNRVLDSFQRARQQTLKKGRRVRPSDPARDDGILAVQIQRTKSGLGASPEELFSGNVSQLQIDRPPPGVEFLPA 
               
               
                 NRRRREARVTARMRVDAAGHMIEFPVVLHRPVPPGARIKAAQLVWKREGERWRGQLCLTVSSPKQEREHPGVEACG 
               
               
                 IDLGWRLQKDGALRVATVADSKSRLYTYTLPADWMRGMDQVERLSSHLDENAMEVAAWVHAHRDELPEKLTQPAAN 
               
               
                 WSPGKGSKWLRDKELHDAVRALNWEVPAEIRHWYERYRHLKTWRDNLRAKLLRSRREVYRLLAADLAGRYAVIGIE 
               
               
                 DMDLSKIAKTKKRKDASDPELHATARAQRQRAAVHALRHEIEHQANKHGAQLVHVSGKTTTTCRACGAATGQKDRA 
               
               
                 SLIWTCEHCGAVWDQDLNAAGNILDSAMGASAPAATTLAKAKSRRYDLTQPNFRERSKTGSRASARA (SEQ ID 
               
               
                 NO: 58) 
               
               
                   
               
               
                 &gt;3300000944|BBAY81_10000005_89 
               
               
                 [algae-green algae-macroalgal surface-ecklonia radiata 2] 
               
               
                 MPVINWVYRSEEPTNVAAVKNQILLNHRYRNQLIELEHNRRATYKTLAASLCPAYADAVTIYDRAVAELDEAYKDL 
               
               
                 RLSRQRARRRHEPTDSQKARINQAKAVRKTAIAQLDAAYKVAKKLIRDAHKVYQDQAAQEITQLADETESQLKRQR 
               
               
                 KVRYFELVEEAGLDDGQIAHAREAKIARQQSGVYWGTSRIMEQIAEKTYKKGPPPKFRRWEGSGAIGVRFQGGKPV 
               
               
                 AAVMENNSEILHIHIPPGSERLVIGQDRGEVAKGTIRFLVCRDDDGNPVFATFPYVHHRDFPASAKIIDGFAHLKR 
               
               
                 VGKKEYWEIRLTIKVDDVVSTVDKSNTCVLHLGHRMIDEQLRCATVMDATQQVSQLFLSSDKLRRFSRPDSLQGIR 
               
               
                 ADRFNIIRGEFLDWLASIDVPEWLVERTQTLASHQSPESLYRTVELWRDNRFVMDTETSAQFFTNSLPWAESKLNS 
               
               
                 PAVRRKRHPSDIQTVFGIMEFWRSWDRHILQESASINKKAIRNRKHVYRDWLRRLSGRYTHLIVDSTNWATLGKKE 
               
               
                 KDDEKVVLVANQRRLARIASPGLLRQCAVEIFGQSNVSVVTSVNMTRTCSTCGQVTEDWDSAKLEYHCSHCTYTVD 
               
               
                 QDINAANIMLSRIPDAVPYTEFAEAKRR (SEQ ID NO: 59) 
               
               
                   
               
               
                 &gt;LSQX01035253_23 
               
               
                 [anaerobic digester metagenome] 
               
               
                 MITVFKYGVHYRWQVPEVLREQLWLGHQLREDLVTLQLEYEAGLKAIWSSYPDVAAAEESLATAAAEALEAAEEVS 
               
               
                 RQRQVQRTKRITGPAADALAAARKRAKEARVVRRSAIAAVKDEAAERISALAAGLRASQKAKYAEYAQGKGLYWAT 
               
               
                 FGDVLDHHKTAVKMVAAKRAAGRPAALRHHRFDGTGAVAVQLQRPAGKPQRTPALISDPVASNWRNVLHLPWVDPE 
               
               
                 QWEQMTRAEQRAQGRVIVRMRCGADIIEVPVQVHRMLPADADITGARLVVAREGSDYRISLTVTARIGDPEPVTAG 
               
               
                 PTVALHFGWRGSDAGPVVVRWQSDAPVDIPNDCSAFMVGDRWGGKIVMPSVIVDRLESAAAIQAGRDEQLNTVRAA 
               
               
                 VVEWLTVNGPVPHPIRDGEEISSADASRWRRPARFAALAGWWRDAPPAGGEQIAEVLEAWRASDKRLWNTQVHTAG 
               
               
                 RALRRRDDLYRQVAAIFADQAGLVVVDDTDMGAVAASRSDAPTAVTDPAARRRTYAAPGVLRASIVAAAAREGVPV 
               
               
                 RSVSHKGMSVIHAECGTVNECDDRFLSALIKCEGCGKVYNQDVNALEVVMREGRRHTSVA (SEQ ID NO: 60) 
               
               
                   
               
               
                 &gt;3300013131|Ga0172373_10056063_2 
               
               
                 [aquatic-freshwater] 
               
               
                 MGSRVFQFGCPFGPSAGLDETIEQMRLGRAYYNARQEVSRQVRNQTRSIYASCGSVSDLERAVEEAKERKDALELE 
               
               
                 IKTARAETRTRWTKKSSAQDLKEARTVLKDARAELGAFRSRLREDPIVAAKLATITGGRPKRKDGEASRRHDNTVK 
               
               
                 NNGTKALAMRALRAEYGPRGKGLGSGTYLLVEAAQGVSEADTPLYDREGQPQDPGFRCWSMGSKHVAVHVQGFELT 
               
               
                 GATIFQPNDWAWIKPVDPRAWLKETPRGERKRLSRTMLHLRLKTGEDREPVWAVVPIIVHREIPLTAKVTWIVLSM 
               
               
                 CQQGPRAVWTCEITVNEEAPQSVPEGRGTAAVVFGWRNVSGGILAATWLNTDGVAGQLVLGDGDLDTTDADGGKGG 
               
               
                 IISGLTRVDSLKETRDKNLNAALASLVSWLRDHDMPEWMRLRTVKRQYDENHQEVQRVLPSKAQALAYLAGWKAQG 
               
               
                 KLAALCLAWRENRFSGDDDAFRALESWRYHDNHLWRWQAAQNESAHLRRRERYRIVGIELAKHARVLLDGTDFARI 
               
               
                 AFRPKTEDDKGYVQGPATNRTLVAPSELRDTVKQAAAKMLRDAVKVESANTAITCPRCGNVSKVQRFDDGDFKHSF 
               
               
                 CCVECGLTGDQDSIRCMNMLVADGHKDAVLEILRRQEEALRYQRRLSNGGDYGEDASNRSENAGVQGAAREVQCDR 
               
               
                 RRGVLLPHDVGG (SEQ ID NO: 61) 
               
               
                   
               
               
                 &gt;3300013136|Ga0172370_10027535_4 
               
               
                 [aquatic-freshwater] 
               
               
                 MVTKRLAYGLLEPTENLETVEDQMSKAHKYYNKLVEIENSIRPLRRESYNNGVKRLSPEYEGLEQQLLALQASKDT 
               
               
                 IENEIKQQRVLNRSKKLDSSNHKQTLAGIKLQIKLVYEKQKEERAKFKGKLKRPSKEKVEPEPHKRPSKEKVEPEP 
               
               
                 HKRPSKEKVEPEPQWLAEQEEIDEKRNKLISEARKASGLYWGTYLSTEDAFKNACKATPPHKNLHFQRWTGEGKIR 
               
               
                 VCRNSEPTVSNSLFFIDPLPGDSWEKKKDKGVPSPRGEGKRSRMKTQLHLLVNSNRQKKIAPVWATFPMMLSRPLP 
               
               
                 DNGRIDSVEVIRKRCGPNWKWAAQVTCTFEETNKPPKGKAIVALDLGWRKIDGNIRVAAFGAIDDAPISLPSESCP 
               
               
                 DLQQAVVKVGNGYELQLTPEVISGIRKSEELRSIRDSEFNDIRSILTRWLQENDVPEEIRTLKKRGKLNVMSQLQF 
               
               
                 IHWINSLRSQAQLASLIYRWKDNRFEGYEEILEALENWRYADQHLWEWESEQRRGAIARRNNLFKNFASWLRSIAT 
               
               
                 MVVIEGDFKITDVAERKGLIEDTNRNEIAQSNRQLAGTSILRICIKNKLGNDCIGVPAKNTSKECHVCGEVVEFAD 
               
               
                 PAALEQECHNHHQWDRDHNAWKVLLKRYASGDVIVKTLGTARKGKKKRNSKKLATGEQKIVG (SEQ ID NO: 
               
               
                 62) 
               
               
                   
               
               
                 &gt;3300013137|Ga0172375_10012175_6 
               
               
                 [aquatic-freshwater] 
               
               
                 MGSRVFQFGCPFGPSAGLDETIEQMRLGRAYYNARQEVSRQVRNQTRSIYASCGSVSDLERAVEEAKERKDALELE 
               
               
                 IKTARAETRTRWTKKSSAQDLKEARTVLKDARAELGAFRSRLREDPIVAAKLATITGGRPKRKDGEASRRHDNTVK 
               
               
                 NNGTKALAMRALRAEYGPRGKGLGSGTYLLVEAAQGVSEADTPLYDREGQPQDPGFRCWSMGSKHVAVHVQGFELT 
               
               
                 GATIFQPNDWAWIKPVDPRAWLKETPRGERKRLSRTMLHLRLKTGEDREPVWAVVPIIVHREIPLTAKVTWIVLSM 
               
               
                 CQQGPRAVWTCEITVNEEAPQSVPEGRGTAAVVFGWRNVSGGILAATWLNTDGVAGQLVLGDGDLDTTDADGGKGG 
               
               
                 IISGLTRVDSLKETRDKNLNAALASLVSWLRDHDMPEWMRLRTVKRQYDENHQEVQRVLPSKAQALAYLAGWKAQG 
               
               
                 KLAALCLAWRENRFSGDDDAFRALESWRYHDNHLWRWQAAQNESAHLRRRERYRIVGIELAKHARVLLDGTDFARI 
               
               
                 AFRPKTEDDKGYVQGPATNRTLVAPSELRDTVKQAAAKMLRDAVKVESANTAITCPRCGNVSKVQRFDDGDFKHSF 
               
               
                 CCVECGLTGDQDSIRCMNMLVADGHKDAVLEILRRQEEALRYQPAAE (SEQ ID NO: 63) 
               
               
                   
               
               
                 &gt;3300010293|Ga0116204_1010874_1 
               
               
                 [aquatic-freshwater-anoxic lake water] 
               
               
                 MLDQLRLASVYRNKLVEIELARRAATDDTLRELCPGLLECEAELADVNAKIAEAIAEHKAKNAKARCLTDDKEIKA 
               
               
                 ALTQLKCIRKELATTRKRLRDDGFSPLTEADLSLVPGLAEATKIHAAAENPHAKAKAAAVMHECRSSWLNDPSRPT 
               
               
                 PIRRLAIQIQLAEIGYAANEAQKTARKTSGLAPGSYLLVDQAADAFRKGAPPVFRGYQGEGRVGVQIVGGMNSEEA 
               
               
                 NSGRDTRLRIVHTPQAEQRVAKNGRVLPAPGAKRQAQQYTLWLRIGSDGRTPTWATWPLILHRPIPETTRIMWAIV 
               
               
                 QRRIVGGHERWQLTLNLRDDTNAAFARRDVTASGVCGVDIGYRYIDDRAQRVAYWHGSDGASGELQLPSGKVAQWK 
               
               
                 KVDDLQSIRDGLHNEARAALRDWLATNAHPEWLDEATEHMHAWRRLSRLDRLVAQWRGQRFDGDAEIMATLESWRT 
               
               
                 RERHLWQYQEQMRDQLLAWRKDFYRNFAAMLRRRYRTIAVEDMDLRSAIHDVLRPEEERETVTAQRRAARFAALSV 
               
               
                 LVAAIKDSGADVVAVEQAGTTSTCSWCGASNEVGTGVIHTCVGCGREWDRDDNAARNICARGEVAVKTR (SEQ 
               
               
                 ID NO: 64) 
               
               
                   
               
               
                 &gt;3300010293|Ga0116204_1010874_2 
               
               
                 [aquatic-freshwater-anoxic lake water] 
               
               
                 MSSKNYTYGLQTPVGNRDRVLDQLRLASVYRNKLVEIELARRAATDDTLRELCPGLLECEAELADVNAKIAEAIAE 
               
               
                 HKAKNAKARCLTDDKEIKAALTQLKCIRKELATTRKRLRDDGFSPLTEADLSLVPGLAEATKIHAAAENPHAKAKA 
               
               
                 AAVMHECRSSWLNDPSRPTPIRRLAIQIQLAEIGYAANEAQKTARKTSGLAPGSYLLVDQAADAFRKGAPPVFRGY 
               
               
                 QGEGRVGVQIVGGMNSEEANSGRDTRLRIVHTPQAEQRVAKNGRVLPAPGAKRQAQQYTLWLRIGSDGRTPTWATW 
               
               
                 PLILHRPIPETTRIMWAIVQRRIVGGHERWQLTLNLRDDTNAAFARRDVTASGVCGVDIGYRYIDDRAQRVAYWHG 
               
               
                 SDGASGELQLPSGKVAQWKKVDDLQSIRDGLHNEARAALRDWLATNAHPEWLDEATEHMHAWRRLSRLDRLVAQWR 
               
               
                 GQRFDGDAEIMATLESWRTRERHLWQYQEQMRDQLLAWRKDFYRNFAAMLRRRYRTIAVEDMDLRSAIHDVLRPEE 
               
               
                 ERETVTAQRRAARFAALSVLVAAIKDSGADVVAVEQAGTTSTCSWCGASNEVGTGVIHTCVGCGREWDRDDNAARN 
               
               
                 ICARGEVAVKTR (SEQ ID NO: 65) 
               
               
                   
               
               
                 &gt;3300008255|Ga0100403_1011992_3 
               
               
                 [aquatic-freshwater-aquifer] 
               
               
                 MTRVFEYGLPFDPFDGAELVDEQILLAHRYYNKLIELEHTRRSSILAVQRADPKVGPLLAAYDAANAEVEDLLARK 
               
               
                 REAKSRDRRVAAPELSEIEAAKEARRHLSVQLRKVKKVATDRLKPEYDLAEQATRDAKKAARAASGVFWGTYSLIE 
               
               
                 QAADAAAKAKPVLRPGTHPRPWDQQPSFRRWTGEGMVAVQININRPLNDVTVFGDDLRLRITPVDPAAWSDATSRG 
               
               
                 DRKCLARTNVTMRVGRNTGETATWPMVMHRPLPAGSRVTWAKVLRWRLDDRPHWFKYVLQLTVETADAPRHPGLVS 
               
               
                 LPPAIVAINCGWRALPNGSLRVVTWVGSDGAEGVLDLGCREYRDRIERAESIRSVRDQLRNELTSKLVGIGIDVTR 
               
               
                 WRSFDRFHRLFRELTAEGCERNEAVELLEAWHHRDRHLRQYQDGARGGALRFRREQYRLLAVELARRYPVVCVESW 
               
               
                 DLRPVVTDEDRLPGPAAARVEGASSTARLALASAATREGCVVLTQIAAHVRLQTQTCHVCGYGAKKGEEWDAAAEL 
               
               
                 VHTCEGCGETWNQDVNFCRNILAASRAAVTEIPELLVPKIMKRSARFAARHKKVAT (SEQ ID NO: 66) 
               
               
                   
               
               
                 &gt;3300014155|Ga0181524_10003409_23 
               
               
                 [aquatic-freshwater-bog] 
               
               
                 MLVYKWGIGPLPLEARQIIDREVRAAHRYRNRLVEIERSRRAAYRDLRNSLSPELAHLHAAYAAADRAVVEGRRLL 
               
               
                 SGVPRAERARHPVAAEVRRLSAARSGAWKAYAEARDRTTADVFGAADQKYREAKQSVTAAVGFACAVARFARGADP 
               
               
                 GPIGPHVLAAITAAVRERALADPAVGEPWKAKTRSQMEHEALAKRARAECGCAVGTYLAVEAAAEKSFAECAGDPP 
               
               
                 FSRLECERVGLQVRGGGLSADDVVGAAVGQVRVEFPADMTARANGTRYAVVHLHLSGRGDQATWLHLPVVWHRDMA 
               
               
                 PEARVRWAYVVARRVGLVWHYELQLTCDSVDRARAQSAGARGTIALNLGWRALKNGDLRVATPWSGSASRAEDRLV 
               
               
                 LPRSFREGSDLADRLLSYADEHFLAVRDALAGWFKGGERSLFSPEQVAAWSLDTVHAWRSHGRLARVALDLRRDWL 
               
               
                 EARGVDVPALWKAWRLERSPKLDLFGPLDEIKAWLAGRGVVSADQVLAVYLDWWRAKDRHLVNWARNNDLRLRRSR 
               
               
                 RDRYRCYARDLAARYERVVIEQWNKSETAETPDPEADTRTEQEVRGNSNRVLACVSELVDALEAAFGEANVHRAPS 
               
               
                 ERITVEHHGCGGESSDPLPQIPVTCFACGQVYDQDLNAAKHLYDRHSGEPSGGVNVGGGARGAKKSRRVEGFGRAA 
               
               
                 E (SEQ ID NO: 67) 
               
               
                   
               
               
                 &gt;3300014156|Ga0181518_10000096_28 
               
               
                 [aquatic-freshwater-bog] 
               
               
                 MLVYKWGIGPLPLEARQIIDREVRAAHRYRNRLVEIERSRRAAYRDLRNSLSPELAHLHAAYAAADRAVVEGRRLL 
               
               
                 SGVPRAERARHPVAAEVRRLSAARSGAWKAYAEARDRTTADVFGAADQKYREAKQSVTAAVGFACAVARFARGADP 
               
               
                 GPIGPHVLAAITAAVRERALADPAVGEPWKAKTRSQMEHEALAKRARAECGCAVGTYLAVEAAAEKSFAECAGDPP 
               
               
                 FSRLECERVGLQVRGGGLSADDVVGAAVGQVRVEFPADMTARANGTRYAVVHLHLSGRGDQATWLHLPVVWHRDMA 
               
               
                 PEARVRWAYVVARRVGLVWHYELQLTCDSVDRARAQSAGARGTIALNLGWRALKNGDLRVATPWSGSASRAEDRLV 
               
               
                 LPRSFREGSDLADRLLSYADEHFLAVRDALAGWFKGGERSLFSPEQVAAWSLDTVHAWRSHGRLARVALDLRRDWL 
               
               
                 EARGVDVPALWKAWRLERSPKLDLFGPLDEIKAWLAGRGVVSADQVLAVYLDWWRAKDRHLVNWARNNDLRLRRSR 
               
               
                 RDRYRCYARDLAARYERVVIEQWNKSETAETPDPEADTRTEQEVRGNSNRVLACVSELVDALEAAFGEANVHRAPS 
               
               
                 ERITVEHHGCGGESSDPLPQIPVTCFACGQVYDQDLNAAKHLYDRHSGEPSGGVNVGGGARGAKKSRRVEGFGRAA 
               
               
                 E (SEQ ID NO: 67) 
               
               
                   
               
               
                 &gt;3300014158|Ga0181521_10000063_92 
               
               
                 [aquatic-freshwater-bog] 
               
               
                 MLVYKWGIGPLPLEARQIIDREVRAAHRYRNRLVEIERSRRAAYRDLRNSLSPELAHLHAAYAAADRAVVEGRRLL 
               
               
                 SGVPRAERARHPVAAEVRRLSAARSGAWKAYAEARDRTTADVFGAADQKYREAKQSVTAAVGFACAVARFARGADP 
               
               
                 GPIGPHVLAAITAAVRERALADPAVGEPWKAKTRSQMEHEALAKRARAECGCAVGTYLAVEAAAEKSFAECAGDPP 
               
               
                 FSRLECERVGLQVRGGGLSADDVVGAAVGQVRVEFPADMTARANGTRYAVVHLHLSGRGDQATWLHLPVVWHRDMA 
               
               
                 PEARVRWAYVVARRVGLVWHYELQLTCDSVDRARAQSAGARGTIALNLGWRALKNGDLRVATPWSGSASRAEDRLV 
               
               
                 LPRSFREGSDLADRLLSYADEHFLAVRDALAGWFKGGERSLFSPEQVAAWSLDTVHAWRSHGRLARVALDLRRDWL 
               
               
                 EARGVDVPALWKAWRLERSPKLDLFGPLDEIKAWLAGRGVVSADQVLAVYLDWWRAKDRHLVNWARNNDLRLRRSR 
               
               
                 RDRYRCYARDLAARYERVVIEQWNKSETAETPDPEADTRTEQEVRGNSNRVLACVSELVDALEAAFGEANVHRAPS 
               
               
                 ERITVEHHGCGGESSDPLPQIPVTCFACGQVYDQDLNAAKHLYDRHSGEPSGGVNVGGGARGAKKSRRVEGFGRAA 
               
               
                 E (SEQ ID NO: 67) 
               
               
                   
               
               
                 &gt;3300014159|Ga0181530_10000119_98 
               
               
                 [aquatic-freshwater-bog] 
               
               
                 MLVYKWGIGPLPLEARQIIDREVRAAHRYRNRLVEIERSRRAAYRDLRNSLSPELAHLHAAYAAADRAVVEGRRLL 
               
               
                 SGVPRAERARHPVAAEVRRLSAARSGAWKAYAEARDRTTADVFGAADQKYREAKQSVTAAVGFACAVARFARGADP 
               
               
                 GPIGPHVLAAITAAVRERALADPAVGEPWKAKTRSQMEHEALAKRARAECGCAVGTYLAVEAAAEKSFAECAGDPP 
               
               
                 FSRLECERVGLQVRGGGLSADDVVGAAVGQVRVEFPADMTARANGTRYAVVHLHLSGRGDQATWLHLPVVWHRDMA 
               
               
                 PEARVRWAYVVARRVGLVWHYELQLTCDSVDRARAQSAGARGTIALNLGWRALKNGDLRVATPWSGSASRAEDRLV 
               
               
                 LPRSFREGSDLADRLLSYADEHFLAVRDALAGWFKGGERSLFSPEQVAAWSLDTVHAWRSHGRLARVALDLRRDWL 
               
               
                 EARGVDVPALWKAWRLERSPKLDLFGPLDEIKAWLAGRGVVSADQVLAVYLDWWRAKDRHLVNWARNNDLRLRRSR 
               
               
                 RDRYRCYARDLAARYERVVIEQWNKSETAETPDPEADTRTEQEVRGNSNRVLACVSELVDALEAAFGEANVHRAPS 
               
               
                 ERITVEHHGCGGESSDPLPQIPVTCFACGQVYDQDLNAAKHLYDRHSGEPSGGVNVGGGARGAKKSRRVEGFGRAA 
               
               
                 E (SEQ ID NO: 67) 
               
               
                   
               
               
                 &gt;3300014201|Ga0181537_10003972_13 
               
               
                 [aquatic-freshwater-bog] 
               
               
                 MSENMPTLVYRYGIAAPHDNADLVYEQLRLAHEYRCSLVRIERTRRAEERAARLAVSAEVAAAEAAVAAADAECER 
               
               
                 LATEIRKARSDARKRVETQQMRDALAKAREVRKERKTALFELRDRYQPQCRDCRATKSEDKPCPHVGQEAQSFCLV 
               
               
                 LDAIAERAKESIRKARAESGLYWGSYLLVDRAMAASRKAPLYGDDGITPNDPKMPRFDGGGAVAIQFQSSSVRPSN 
               
               
                 VRLADLGPDNARLQIVLPPWPEQCMPAPESHQGPFDPSRPPAGMRPDGTLAPATRADGSPARWLRRRANRQALVRM 
               
               
                 CVKTEGRGKPVWAAWRLDYDRPLPAQAIISWATIHRRMRGPHAEWSLCLTVEVAAEPAAEIRSGQVAIDVGWRQMP 
               
               
                 CPGGAACHGQRTDCHELRVAAWRDHGGGSGELRLSARDIRALRQPAELRSKRDTQFDAIKAAVAGWIRSASDAPEW 
               
               
                 MREAAKVMHAWRWQGRMVALVRQWAQERPNRAAPEEAVYQAALAWQTADWALWESERARDAWAHRRRREIYRVWAA 
               
               
                 RMAETYGTLILERFDLRDVTERAPVGQDDSENETARSNRHLAAVSELRGALCNAVRTRGSEVVGVTAVNSTRTCPS 
               
               
                 CGLVSDRNQAQAVQLACECGHVWDQDVEGAAPWLLAEYRERPGDAKLQAGARAEAIAAARKGKKGNDWARAKRMGA 
               
               
                 AKKGRLQAARESAATEAQ (SEQ ID NO: 68) 
               
               
                   
               
               
                 &gt;3300014201|Ga0181537_10021284_1 
               
               
                 [aquatic-freshwater-bog] 
               
               
                 MKLVYKYGLATPHDNRELVEEQMRAAHRYRNTLTEIERGRRAAVRQAEAEAGDMPKALQALRASEAELEAALTAIR 
               
               
                 RHRARTSKRDEPVALKASAKAAREAKRAASKAFRDLRRRIAEDPMVVAAKDAIGERANELGRSARAHSGVYWGSYL 
               
               
                 LVEAAASASFEDTPMYASDGRPTDPAFVRWTGEGEVGVQLQGGLGADEATACTDTQLQITQPDERAWERRGRTHRE 
               
               
                 CEQMARQAQLRMRVQSDAKGKPVWATWRMDMHRPLPEGAIIKLATVHRVRVGPHSKWYVTITLDVPARARVSPSSG 
               
               
                 TVAVDVGWRVVGDELRVAGWQDTTGARGELRLSPRDIAMLRAPEAMRSERDRRFDAARANLLGWLRSHQELVPEWL 
               
               
                 AKATTTLHAWRSEARLVALYSRWSGSRFEGDEQPYYALASWRARARHEWAVESCARDQALRRRRERYRVWAAQLAS 
               
               
                 KYNTIVIEKFDKREVAVIPAPDVQVEQNAEQAARDKAARSNRFLAATSELCDCLVTAARSRGCTVIAVPCEDTTRT 
               
               
                 CPVCGLVESRDAAAAIELTCECGASWDQDVDGAPAVLLARARERPGDTKILVGAREDEKKNENGQKPESQWQRVRR 
               
               
                 MRAEKEARMGTAREAAPEGAE (SEQ ID NO: 69) 
               
               
                   
               
               
                 &gt;3300014201|Ga0181537_10040512_3 
               
               
                 [aquatic-freshwater-bog] 
               
               
                 MTTRVYQFALLPPSGRDAALVDAQMRLAWEARQDMAMIERGRRSAMRALLDTPDVRAAEEALKAATRSTRKDVIRV 
               
               
                 VSRARRDALERAVASERYDDEACQETGYCPLYEPERIEQLAKLATKGAYHYFGDRGLAWGTRLDVSGAADAARKAP 
               
               
                 LYDDDGLTPSDPHVERWYDAKRPPDSQLAVQLQGGLSTPDGLTGQDTRVRLVDGVLWLRVGSDGRAPVWAKFAIAR 
               
               
                 PHRTGKRGVRTTHRAIPDDAKWKWVRVSRRRDGPWMRWSVEITLDVEREDWRVRDPQVQGVLAVEVCWDRPDDAIV 
               
               
                 VARWRDDSGRSGTIELPDRIATGLPKVHGIRAVRDTIRADMAKRLQRALTEDRDPKPVWLADAAGSMHLWKSSSRF 
               
               
                 HRLIQQWQDERCDAARPAYELLDAWRLRDNHLYEYETGARGNVLRWRKNWYQTLAAEWARRYRIVVLDDRNLSREA 
               
               
                 RWGEASEIRFMASPFELRQAIRNAFGRDVAEHTVKQTEKEKDEDDRDWCERALDARNAGVARTERETSEIKDKRGG 
               
               
                 AWAKRKQAKTTRHAEREAARKAVVKAAE (SEQ ID NO: 70) 
               
               
                   
               
               
                 &gt;3300014654|Ga0181525_10000532_4 
               
               
                 [aquatic-freshwater-bog] 
               
               
                 MAVYVYQFGLSAPFGENADLVYDQLFATHRYRNTLIEIERGRRAAVRAVIDASNAQTVALTAEVARWNAETEALAK 
               
               
                 RIKSQRASTRTRSESESDREALRQAREARKAAVTKLREARLAQRTDAAMTAAIDAINERANGLVRGARELTETYWG 
               
               
                 TYLLTEKAMQDSKALPLYGDDGISPNDPKFLRWEGDGALGVQIQGGAKAATILAEASTLLRMRPDARAYLERACDQ 
               
               
                 RRIKDKTGLLTMRVGSDAKGGPIWATWHMHMHRLIPENAMIKGATVHLRKVGTKAEWSLEVTVEHSRAALPPNDKT 
               
               
                 IAIDIGWRMIGDELRVAGWMDSDGKTGELRLSAKDIRLLRRPEEIRGERDRHFTLAKTALGSFLASAAQVPDRLRA 
               
               
                 ETAHLDRWGSADRLAAVVARWERFEGDAAIHNVMTAWFWRDRNLCDQEAGMRLQALRRRKNKYREWAAWVTETYGT 
               
               
                 VVVEKFDLRAVALRGAVEDPAANETARSNRQLAALSEARTAIVNAASSRGRLIAAMPAHDTTRACPSCGVVEAREA 
               
               
                 EASIVLVCPDCGATWDQDVTGAPVVLLGRWRERPGDAKILVSARDGANDNESETMRPNRWQKVKEARTAKVLRRES 
               
               
                 ARAEASNGAE (SEQ ID NO: 71) 
               
               
                   
               
               
                 &gt;3300014657|Ga0181522_10000394_52 
               
               
                 [aquatic-freshwater-bog] 
               
               
                 MKELRGNHELRNRLVEIERERRKAVRALCADLPELAAAQVCRTALDEALQTIKKARSETKKRSESAEDVKRAKEAR 
               
               
                 KAYQEALRALALARRARLSACEAEIKVVNDESAKREKEAYGESPVEAWGSKLDVFAAHAAVRAMPYWDELADNDPH 
               
               
                 FVRWEGEGQIAVQLQGGLRVGAALSGGDRRFQLTDLVPEAFEATDAAKNPRDRRRLRGAVGRLRIGSDARNPIWTE 
               
               
                 VRVQVHRPLPPSGIIKWARLSRRRVALAYAWSLEVTVDVPLSAVARPGVVGLDLGWRKKPDGSLRVGYLAFRETAK 
               
               
                 DAIATRTRELVLPASLVQRFARLREAESERTHAFEMERMWLSRLLSTFVELPDWLKKESETLSQWRSPARLARLAR 
               
               
                 IWSENRFERDELPYERLRGWAAGDALRYQENEEARQSALRAREWYYGNWAAACANAYGALAVENMNISRLIRHRDP 
               
               
                 DADEPAHEERARSRAVAAPGRLRQVFAHAFEGRGGIVMLRPTKNTTITCPTCGDVRKFDAAEILAPTCANGHTIDQ 
               
               
                 DERAARNLCEGVSGEEAAEAARAREVRESTPKESRWAKVKRMKREKEEGALARGVGSAG (SEQ ID NO: 72) 
               
               
                   
               
               
                 &gt;3300014657|Ga0181522_10000394_53 
               
               
                 [aquatic-freshwater-bog] 
               
               
                 MNRVYRYSCSPPKTEAERVMKELRGNHELRNRLVEIERERRKAVRALCADLPELAAAQVCRTALDEALQTIKKARS 
               
               
                 ETKKRSESAEDVKRAKEARKAYQEALRALALARRARLSACEAEIKVVNDESAKREKEAYGESPVEAWGSKLDVFAA 
               
               
                 HAAVRAMPYWDELADNDPHFVRWEGEGQIAVQLQGGLRVGAALSGGDRRFQLTDLVPEAFEATDAAKNPRDRRRLR 
               
               
                 GAVGRLRIGSDARNPIWTEVRVQVHRPLPPSGIIKWARLSRRRVALAYAWSLEVTVDVPLSAVARPGVVGLDLGWR 
               
               
                 KKPDGSLRVGYLAFRETAKDAIATRTRELVLPASLVQRFARLREAESERTHAFEMERMWLSRLLSTFVELPDWLKK 
               
               
                 ESETLSQWRSPARLARLARIWSENRFERDELPYERLRGWAAGDALRYQENEEARQSALRAREWYYGNWAAACANAY 
               
               
                 GALAVENMNISRLIRHRDPDADEPAHEERARSRAVAAPGRLRQVFAHAFEGRGGIVMLRPTKNTTITCPTCGDVRK 
               
               
                 FDAAEILAPTCANGHTIDQDERAARNLCEGVSGEEAAEAARAREVRESTPKESRWAKVKRMKREKEEGALARGVGS 
               
               
                 AG (SEQ ID NO: 73) 
               
               
                   
               
               
                 &gt;3300009175|Ga0073936_10014029_2 
               
               
                 [aquatic-freshwater-freshwater lake hypolimnion] 
               
               
                 MNPASMAPKGMIVGLLMTYNIYLPLLFCKFEACRIYLGVLAIGQARYTSEKLEAKKMLDKGAKVTFTYDGNETSGK 
               
               
                 ILHILAAGKKPAAYFDILTAADKALEADRCFDETRSCEDESYLVVTKRSKNTVAKIYWLSKDDLSGVQVVVRQYGL 
               
               
                 LQPSNWQDDCFNHLYLQNRYWNCLVEIEQDNRNKYRALVGEDEDVAPIQDAIDGLKSRIADMAEQRTQLKIEHCKK 
               
               
                 IGIHTEPLDNAIKAAKAEMKKLSNKAKEARAVAKERIRAAGPAFKLLEDERRQSVKEAYNNSQLWWGNYNAITNSY 
               
               
                 NTARTRAMKEGADLRFHRFDGSGRFTCQIMGGMSTDDLLSGRNSVAQLRKVSNSEFTKIIKSNPPALQLQLVGSRR 
               
               
                 DEREYGVLSITIYTAEDDQGKKTRRTLDFPIILHRPLPENATLKIISVNRKKIGTDYRWAVTFTFSEETKESIVHT 
               
               
                 SKQTCGINLGWKQVAGGLRVATVSDGTSTRHVVLPQVIIDKLAYTESLQSRIDTATNENFIWLLGKMADPPEILKG 
               
               
                 DVTSLKRSKRPHPAKFAKFVIKWRNECSEFEPQALIEAEVMRKNVKRLSLEHHHLRDKVLRRRIDFYRNEAKKIAD 
               
               
                 KYSMIVMDKMDLRQMSALEKSDGTPNELADLARYHRKVAAISEFREWIGKQAIKAGGAVEMIAIESTRTCNACDGV 
               
               
                 MAPSDGLMFRCKSCGTFVDQDENASANLLRAVT (SEQ ID NO: 74) 
               
               
                   
               
               
                 &gt;3300015360|Ga0163144_10020017_5 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MSVRVYKYGLRRPHEQGERVRAQMRAAHRYRNTLVEIERARRTAVRSAMSAYGNIGELEAAARSADVVVSDAVRLA 
               
               
                 KAAKAEARSHSGVSSDQKAALLAARERKRDAVRLLRETRVLLRQDVVLSTEVDRVNELAAELRRNARKHCGVYWGT 
               
               
                 YLLIEAADEAARKVPLYDGAEPSDPRFMRWAGEGRVGVSIAKGADIAVLDDTKDTRIRIEPGTMPKGADPASKRSA 
               
               
                 KRRHAVLAMRVGSGDQREPVFARWEMVMHRSLPAGARIKNAAVSLRLVGPREEWSVAITLDTTACAETATRGRGVV 
               
               
                 GVDLGWRMLNGDIRSAAWDGGDVSGFLALPAELIGQVEKVADLRSIRSKNFDASRAALVAAMPADAPAWLRGATAS 
               
               
                 LGQWKSIDRLTKLALRWRVARFDGDAAAYDALEAWRYNDHHLWCWESEQRTRTLRHRREIYRIFAAKLAREYETLA 
               
               
                 IENFDLRVFSVRAPVETDASIDTVTRAARVVVSPSELRLSLVNAFGPHRVVKVDAANTTRECSECHHINTWDAAAE 
               
               
                 LSHTCAQCGARWDQDANAARVIRARGTAASPAPGAARNGDSANDSAAPIESRWAKAKRMRAEKRSGEGGARKPVDA 
               
               
                 AAE (SEQ ID NO: 75) 
               
               
                   
               
               
                 &gt;3300015360|Ga0163144_10020017_4 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MRAAHRYRNTLVEIERARRTAVRSAMSAYGNIGELEAAARSADVVVSDAVRLAKAAKAEARSHSGVSSDQKAALLA 
               
               
                 ARERKRDAVRLLRETRVLLRQDVVLSTEVDRVNELAAELRRNARKHCGVYWGTYLLIEAADEAARKVPLYDGAEPS 
               
               
                 DPRFMRWAGEGRVGVSIAKGADIAVLDDTKDTRIRIEPGTMPKGADPASKRSAKRRHAVLAMRVGSGDQREPVFAR 
               
               
                 WEMVMHRSLPAGARIKNAAVSLRLVGPREEWSVAITLDTTACAETATRGRGWGVDLGVVRMLNGDIRSAAWDGGDV 
               
               
                 SGFLALPAELIGQVEKVADLRSIRSKNFDASRAALVAAMPADAPAWLRGATASLGQWKSIDRLTKLALRWRVARFD 
               
               
                 GDAAAYDALEAWRYNDHHLWCWESEQRTRTLRHRREIYRIFAAKLAREYETLAIENFDLRVFSVRAPVETDASIDT 
               
               
                 VTRAARVVVSPSELRLSLVNAFGPHRVVKVDAANTTRECSECHHINTWDAAAELSHTCAQCGARWDQDANAARVIR 
               
               
                 ARGTAASPAPGAARNGDSANDSAAPIESRWAKAKRMRAEKRSGEGGARKPVDAAAE (SEQ ID NO: 76) 
               
               
                   
               
               
                 &gt;3300015360|Ga0163144_10033243_8 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MSIRVYKYGLRRPHEQSERVRAQMLAAHRYRNTLVEIERARRAAVRSAMSAYGNIGELEAAAHAADTVVLGVVRLA 
               
               
                 KAAKAEARSHSGISSDQKAALSAAREHRRDAVRLLRETRVLLRQDVVLSTEVDRVSELACELRKSARKHCGVYWGT 
               
               
                 YLLIEAADEAARKAPLYDGAEPSDPRFARWIGEGRVGVSIMKGADISVLDMEDTRIRIEPGTMPKGADPTSKRSAK 
               
               
                 RRHTVLAMRVGSDDQRGPIFARWEMVMHRPLPAGARIKNAAVSLRLVGPREEWSVAITLDTTACAETATSGRGVVG 
               
               
                 VDLGWRMLDGDIRSAAWDGGDLSGYLALPAELIGQVEKVADLRSIRSKSFDASRDALIAVMPTNAPAWLRAATSSL 
               
               
                 RQWKSINRLTKLALRWRVARFDGDAAAYDALEAWRYNDHHLWCWESEQRTRTLRHRREIYRIFAAKLARKYETLAI 
               
               
                 ENFDLRVFSVRAPVETDASIDTITRAVRVVVSPSELRRSLINAFGPHRVVKVDAANTTRECAECHHINTWDAAAEL 
               
               
                 SHTCAQCSARWDQDANAARIIRARGAAASPQGRNSDSATTTESRWAKAKRMRAEKRSGEGGDRKSVDTAAE (SEQ 
               
               
                 ID NO: 77) 
               
               
                   
               
               
                 &gt;3300015360|Ga0163144_10033243_7 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MSAYGNIGELEAAAHAADTVVLGVVRLAKAAKAEARSHSGISSDQKAALSAAREHRRDAVRLLRETRVLLRQDVVL 
               
               
                 STEVDRVSELACELRKSARKHCGVYWGTYLLIEAADEAARKAPLYDGAEPSDPRFARWIGEGRVGVSIMKGADISV 
               
               
                 LDMEDTRIRIEPGTMPKGADPTSKRSAKRRHTVLAMRVGSDDQRGPIFARWEMVMHRPLPAGARIKNAAVSLRLVG 
               
               
                 PREEWSVAITLDTTACAETATSGRGVVGVDLGWRMLDGDIRSAAWDGGDLSGYLALPAELIGQVEKVADLRSIRSK 
               
               
                 SFDASRDALIAVMPTNAPAWLRAATSSLRQWKSINRLTKLALRWRVARFDGDAAAYDALEAWRYNDHHLWCWESEQ 
               
               
                 RTRTLRHRREIYRIFAAKLARKYETLAIENFDLRVFSVRAPVETDASIDTITRAVRVVVSPSELRRSLINAFGPHR 
               
               
                 VVKVDAANTTRECAECHHINTWDAAAELSHTCAQCSARWDQDANAARIIRARGAAASPQGRNSDSATTTESRWAKA 
               
               
                 KRMRAEKRSGEGGDRKSVDTAAE (SEQ ID NO: 78) 
               
               
                   
               
               
                 &gt;3300015360|Ga0163144_10062707_6 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MSSRSKENRMFGHESKPTRNYVYGILAPTEGADLVDEQLRAAHQYRNNLVRLELDRREAVQQCLLAMRPAVARLTG 
               
               
                 EVADAVTAYDAAAAALKVRNARERNKRASADERQASKDAAALLKGLRGQLKAVRTEAFAADDVRAALDAIETVASE 
               
               
                 RRREARGACGVYWGTYLTVEQAAGSFRSGAPPIFHRWTGEGRLAIQLQNGVEPAVLTLGQDKRLRIELTGECGRGK 
               
               
                 RPLAVAWLRVGSDGRAPVWAKFPMVYHRPIPVDAKIKWAFVHRRRCGTFWRWQLMLSVARDAWESPTTSGGSVGID 
               
               
                 LGWRVVPEGLRVASWAGDDGRRGELILPADDLRRWSEPATRRAERDVRFGEFLPRVADWFAANAGRFGEEMRERVK 
               
               
                 TIRQWRSPARLAGLLRAWSAERVTGDEEIYGELVRWMREDSREWNSESGQRARASRWRDDYYRCFVKRLASEYRVV 
               
               
                 HVEDMDLREIKRKPKAEEAESENQTARGNAFIASPGRLRELIREGFAETMSIDAAWTTQRCHACGEIDGFDAAAEL 
               
               
                 VRTCRHCGVAEDQDYRAAMNLLHGEQPDADEMAVVARGV (SEQ ID NO: 79) 
               
               
                   
               
               
                 &gt;3300015360|Ga0163144_10062707_6 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MFGHESKPTRNYVYGILAPTEGADLVDEQLRAAHQYRNNLVRLELDRREAVQQCLLAMRPAVARLTGEVADAVTAY 
               
               
                 DAAAAALKVRNARERNKRASADERQASKDAAALLKGLRGQLKAVRTEAFAADDVRAALDAIETVASERRREARGAC 
               
               
                 GVYWGTYLTVEQAAGSFRSGAPPIFHRWTGEGRLAIQLQNGVEPAVLTLGQDKRLRIELTGECGRGKRPLAVAWLR 
               
               
                 VGSDGRAPVWAKFPMVYHRPIPVDAKIKWAFVHRRRCGTFWRWQLMLSVARDAWESPTTSGGSVGIDLGWRVVPEG 
               
               
                 LRVASWAGDDGRRGELILPADDLRRWSEPATRRAERDVRFGEFLPRVADWFAANAGRFGEEMRERVKTIRQWRSPA 
               
               
                 RLAGLLRAWSAERVTGDEEIYGELVRWMREDSREWNSESGQRARASRWRDDYYRCFVKRLASEYRVVHVEDMDLRE 
               
               
                 IKRKPKAEEAESENQTARGNAFIASPGRLRELIREGFAETMSIDAAWTTQRCHACGEIDGFDAAAELVRTCRHCGV 
               
               
                 AEDQDYRAAMNLLHGEQPDADEMAVVARGV (SEQ ID NO: 80) 
               
               
                   
               
               
                 &gt;3300020057|Ga0163151_10006104_16 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MSVRVYKYGLRRPHEQGERVRAQMRAAHRYRNTLVEIERARRTAVRSAMSAYGNIGELEAAARSADVVVSDAVRLA 
               
               
                 KAAKAEARSHSGVSSDQKAALLAARERKRDAVRLLRETRVLLRQDVVLSTEVDRVNELAAELRRNARKHCGVYWGT 
               
               
                 YLLIEAADEAARKVPLYDGAEPSDPRFMRWAGEGRVGVSIAKGADIAVLDDTKDTRIRIEPGTMPKGADPASKRSA 
               
               
                 KRRHAVLAMRVGSGDQREPVFARWEMVMHRSLPAGARIKNAAVSLRLVGPREEWSVAITLDTTACAETATRGRGVV 
               
               
                 GVDLGWRMLNGDIRSAAWDGGDVSGFLALPAELIGQVEKVADLRSIRSKNFDASRAALVAAMPADAPAWLRGATAS 
               
               
                 LGQWKSIDRLTKLALRWRVARFDGDAAAYDALEAWRYNDHHLWCWESEQRTRTLRHRREIYRIFAAKLAREYETLA 
               
               
                 IENFDLRVFSVRAPVETDASIDTVTRAARVVVSPSELRLSLVNAFGPHRVVKVDAANTTRECSECHHINTWDAAAE 
               
               
                 LSHTCAQCGARWDQDANAARVIRARGTAASPAPGAARNGDSANDSAAPIESRWAKAKRMRAEKRSGEGGARKPVDA 
               
               
                 AAE (SEQ ID NO: 75) 
               
               
                   
               
               
                 &gt;3300020186|Ga0163153_10017638_7 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MTSVYRYGLLPPTLGADVVDDQMRAGHRYQNALVELERARRDAVAGVLSNNAIDEIDLEIKALDEELSARRAAIQA 
               
               
                 ERGATKRKRVPHTTATRDIARRRELRGTRRTLIAARRADPAVMAALAGIEERAKVLHKQFRADSGVYWCTYLKVEQ 
               
               
                 AMDAARKGAKFGPPSFRRWNGGGAVSMQLQRRGPERLLMTADNAIECDDPRLHLDLIPTPVPNRRGKPLPRVRLRV 
               
               
                 GSDGARRPIWAEWPMIYHRPLPDGAVITWATVIRELVASSPRWALLLTIEHGGVAPTAARGAAVAVDLGWRRAIVD 
               
               
                 GDITTRACGHTATDDSDESELHVHRDVFGALGKADNLRSIRDKRMNEMQAILVAWLRGCGSEEHRERTRFVAQWRA 
               
               
                 CARFAGLAIWWRDHRIEGDELIFVLLEAWRKRDKHLWLWEAHARRTARARRLDGYRVFAADLARRYETLIVEKINL 
               
               
                 AKVAEKPKPESTREHNATASSQRTATAPSELRGALVNAFRGRGGTVVEVGAHPSATAMLGEWRERPVAEEKPGVAR 
               
               
                 MSKFGRLRAERGGSWAQRSRPLEGGSASD (SEQ ID NO: 81) 
               
               
                   
               
               
                 &gt;3300020195|Ga0163150_10003396_14 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MTSVYRYGLLPPTLGADVVDDQMRAGHRYQNALVELERARRDAVAWVLSDGVIDEIDRGIEALSEELSAQRAGIQA 
               
               
                 ERGATKRKRVPHTAETRGLDDRRRELRGTRRTLIAARRADPAVMAALAGIEERAKVLSKLLSKSSGVHWGTKGVVH 
               
               
                 QAMDAARKGAKFGPPSFRRWNGGGAVSMQLQRTGREKRPLTADDAIECDDTRLHLDLTPTPVPNRRGKPRRGKPLP 
               
               
                 RVRLRVGSDGARRPIWAEWPMIYHRPLPDGAVITWATVIRELVASSPRWALLLTIEHGGVAPTAARGAAVAVDLGW 
               
               
                 RRAIVDGDITTRACGHTATDDSDESELHVHRDVFGALGKADNLRSIRDKRMNEMQAILVAWLRGCGSEEHRERTRF 
               
               
                 VAQWRACARFAGLAIWWRDHRMEGDELIFVLLEAWRKRDKHLWLWEAHARRTARARRLDGYRVFAADLARRYETLI 
               
               
                 VEKINLAKVAEKPKPESTREHNATASWQRTATAPSELRGALVNAFRGRGGTVVEVGAHPSATAMLGEWRERPVAEE 
               
               
                 KPGVARMSKFGRLRAERGGSWAQRSRPPEPLEGGSASD (SEQ ID NO: 82) 
               
               
                   
               
               
                 &gt;3300020203|Ga0163148_10001247_2 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MFGHESKPTRNYVYGILAPTEGADLVDEQLRAAHQYRNNLVRLELDRREAVQQCLLAMRPAVARLTGEVADAVTAY 
               
               
                 DAAAAALKVRNARERNKRASADERQASKDAADLLKGLRGQLKAVRTEAFAADDVRAALDAIETVFRERRREARGAS 
               
               
                 DVYWGTYLTVEQAAWSFRSGAPPIFHRWTGEGRLAIQLQNGVEPAVLTLGQDKRLRIELTGEYGRGKRGKRPLAVA 
               
               
                 WFRVGSDGHTPVWAKFPMVYHRPIPVDAKIKWAFVHRRRCGTFWRWQLMLSVARDAWESPITSGGSVGIDLGWRVV 
               
               
                 PEGLRVASWAGDDGRRGELILPADDLRRWSEPATRRAERDVRFGEFLPRVADWFAANSGRFSEAMRERVKSIRQWK 
               
               
                 SPARLAGLLRAWGDERVVGDEEIHAELVTWMREDSREWNSEAGQRARASRWRDDYYRCFVKRLAIEYRVVHVEDMD 
               
               
                 LREIKRKPKAEEAESENQTARGNAFIASPGRLRELIREGFAETMSIDAAWTTQRCHACGEIDGFDAAAELVRTCRH 
               
               
                 CGVTEDQDYRAAMNLLAGEQPDADEMAGVARGV (SEQ ID NO: 83) 
               
               
                   
               
               
                 &gt;3300020203|Ga0163148_10001247_2 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MSSRSKENRMFGHESKPTRNYVYGILAPTEGADLVDEQLRAAHQYRNNLVRLELDRREAVQQCLLAMRPAVARLTG 
               
               
                 EVADAVTAYDAAAAALKVRNARERNKRASADERQASKDAADLLKGLRGQLKAVRTEAFAADDVRAALDAIETVFRE 
               
               
                 RRREARGASDVYWGTYLTVEQAAWSFRSGAPPIFHRWTGEGRLAIQLQNGVEPAVLTLGQDKRLRIELTGEYGRGK 
               
               
                 RGKRPLAVAWFRVGSDGHTPVWAKFPMVYHRPIPVDAKIKWAFVHRRRCGTFWRWQLMLSVARDAWESPITSGGSV 
               
               
                 GIDLGWRVVPEGLRVASWAGDDGRRGELILPADDLRRWSEPATRRAERDVRFGEFLPRVADWFAANSGRFSEAMRE 
               
               
                 RVKSIRQWKSPARLAGLLRAWGDERVVGDEEIHAELVTWMREDSREWNSEAGQRARASRWRDDYYRCFVKRLAIEY 
               
               
                 RVVHVEDMDLREIKRKPKAEEAESENQTARGNAFIASPGRLRELIREGFAETMSIDAAWTTQRCHACGEIDGFDAA 
               
               
                 AELVRTCRHCGVTEDQDYRAAMNLLAGEQPDADEMAGVARGV (SEQ ID NO: 84) 
               
               
                   
               
               
                 &gt;3300020213|Ga0163152_10009495_14 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MSSRSKENRMFGHESKPTRNYVYGILAPTEGADLVDEQLRAAHQYRNNLVRLELDRREAVQQCLLAMRPAVARLTG 
               
               
                 EVADAVTAYDAAAAALKVRNARERNKRASADERQASKDAAALLKGLRGQLKTVRTEAFAADDVRAALDAIETVASE 
               
               
                 RRREARGACGVYWGTYLTVEQAAGSFRSGAPPIFHRWTGEGRLAIQLQNGVEPAVLTLGQDKRLRIELTGECGRGK 
               
               
                 RPLAVAWLRVGSDGRAPVWAKFPMVYHRPIPVDAKIKWAFVHRRRCGTFWRWQLMLSVARDAWESPTTSGGSVGID 
               
               
                 LGWRVVPEGLRVASWAGDDGRRGELILPADDLRRWSEPATRRAERDVRFGEFLPRVADWFAANAGRFGEEMRERVK 
               
               
                 TIRQWRSPARLAGLLRAWSAERVTGDEEIYGELVRWMREDSREWNSESGQRARASRWRDDYYRCFVKRLASEYRVV 
               
               
                 HVEDMDLREIKRKPKAEEAESENQTARGNAFIASPGRLRELIREGFAETMSIDAAWTTQRCHACGEIDGFDAAAEL 
               
               
                 VRTCRHCGVTEDQDYRAAMNLLHGEQPDADEMAGVARGV (SEQ ID NO: 85) 
               
               
                   
               
               
                 &gt;3300020213|Ga0163152_10009495_14 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MFGHESKPTRNYVYGILAPTEGADLVDEQLRAAHQYRNNLVRLELDRREAVQQCLLAMRPAVARLTGEVADAVTAY 
               
               
                 DAAAAALKVRNARERNKRASADERQASKDAAALLKGLRGQLKTVRTEAFAADDVRAALDAIETVASERRREARGAC 
               
               
                 GVYWGTYLTVEQAAGSFRSGAPPIFHRWTGEGRLAIQLQNGVEPAVLTLGQDKRLRIELTGECGRGKRPLAVAWLR 
               
               
                 VGSDGRAPVWAKFPMVYHRPIPVDAKIKWAFVHRRRCGTFWRWQLMLSVARDAWESPTTSGGSVGIDLGWRVVPEG 
               
               
                 LRVASWAGDDGRRGELILPADDLRRWSEPATRRAERDVRFGEFLPRVADWFAANAGRFGEEMRERVKTIRQWRSPA 
               
               
                 RLAGLLRAWSAERVTGDEEIYGELVRWMREDSREWNSESGQRARASRWRDDYYRCFVKRLASEYRVVHVEDMDLRE 
               
               
                 IKRKPKAEEAESENQTARGNAFIASPGRLRELIREGFAETMSIDAAWTTQRCHACGEIDGFDAAAELVRTCRHCGV 
               
               
                 TEDQDYRAAMNLLHGEQPDADEMAGVARGV (SEQ ID NO: 86) 
               
               
                   
               
               
                 &gt;3300020219|Ga0163146_10006198_18 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MSVRVYKYGLRRPHEQGERVRAQMRAAHRYRNTLVEIERARRTAVRSAMSAYGNIGELEAAARSADVVVSDAVRLA 
               
               
                 KAAKAEARSHSGVSSDQKAALLAARERKRDAVRLLRETRVLLRQDVVLSTEVDRVNELAAELRRNARKHCGVYWGT 
               
               
                 YLLIEAADEAARKVPLYDGAEPSDPRFMRWAGEGRVGVSIAKGADIAVLDDTKDTRIRIEPGTMPKGADPASKRSA 
               
               
                 KRRHAVLAMRVGSGDQREPVFARWEMVMHRSLPAGARIKNAAVSLRLVGPREEWSVAITLDTTACAETATRGRGVV 
               
               
                 GVDLGWRMLNGDIRSAAWDGGDVSGFLALPAELIGQVEKVADLRSIRSKNFDASRAALVAAMPADAPAWLRGATAS 
               
               
                 LGQWKSIDRLTKLALRWRVARFDGDAAAYDALEAWRYNDHHLWCWESEQRTRTLRHRREIYRIFAAKLAREYETLA 
               
               
                 IENFDLRVFSVRAPVETDASIDTVTRAARVVVSPSELRLSLVNAFGPHRVVKVDAANTTRECSECHHINTWDAAAE 
               
               
                 LSHTCAQCGARWDQDANAARVIRARGTAASPAPGAARNGDSANDSAAPIESRWAKAKRMRAEKRSGEGGARKPVDA 
               
               
                 AAE (SEQ ID NO: 75) 
               
               
                   
               
               
                 &gt;3300020596|Ga0163149_10010333_13 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MSVRVYRYGLRRPHEQGERVRAQMRAAHRYRNTLVEIERARRTAVRSAMSAYGNIGELEAAARSADVVVSDAVRLA 
               
               
                 KAAKAEARSHSGVSSDQKAALSAARERKRDAVRLLRETRVLLRQDVVLSTEVDRVNELAAELRRNARKHCGVYWGT 
               
               
                 YLLIEAADEAARKVPLYDGAEPSDPRFMRWAGEGRVGVSIAKGADIAVLDDTKDTRIRIEPGTMPKGADPASKRSA 
               
               
                 KRRHAVLAMRVGSGDQREPVFARWEMVMHRSLPAGARIKNAAVSLRLVGPREEWSVAITLDTTACAETATRGRGVV 
               
               
                 GVDLGWRMLNGDIRSAAWDGGDVSGFLALPAELIGQVEKVADLRSIRSKNFDASRAALVAAMPADAPAWLRGATAS 
               
               
                 LGQWKSIDRLTKLALRWRVARFDGDAAAYDALEAWRYNDHHLWCWESEQRTRTLRHRREIYRIFAAKLAREYETLA 
               
               
                 IENFDLRVFSVRAPVETDASIDTVTRAARVVVSPSELRLSLVNAFGPHRVVKVDAANTTRECSECHHINTWDAAAE 
               
               
                 LSHTCAQCGARWDQDANAARVIRARGTAASPAPGAARNGDSANDSAAPIESRWAKAKRMRAEKRSGEGGARKPVDA 
               
               
                 AAE (SEQ ID NO: 87) 
               
               
                   
               
               
                 &gt;3300020596|Ga0163149_10010333_12 
               
               
                 [aquatic-freshwater-freshwater microbial mat] 
               
               
                 MRAAHRYRNTLVEIERARRTAVRSAMSAYGNIGELEAAARSADVVVSDAVRLAKAAKAEARSHSGVSSDQKAALSA 
               
               
                 ARERKRDAVRLLRETRVLLRQDVVLSTEVDRVNELAAELRRNARKHCGVYWGTYLLIEAADEAARKVPLYDGAEPS 
               
               
                 DPRFMRWAGEGRVGVSIAKGADIAVLDDTKDTRIRIEPGTMPKGADPASKRSAKRRHAVLAMRVGSGDQREPVFAR 
               
               
                 WEMVMHRSLPAGARIKNAAVSLRLVGPREEWSVAITLDTTACAETATRGRGVVGVDLGWRMLNGDIRSAAWDGGDV 
               
               
                 SGFLALPAELIGQVEKVADLRSIRSKNFDASRAALVAAMPADAPAWLRGATASLGQWKSIDRLTKLALRWRVARFD 
               
               
                 GDAAAYDALEAWRYNDHHLWCWESEQRTRTLRHRREIYRIFAAKLAREYETLAIENFDLRVFSVRAPVETDASIDT 
               
               
                 VTRAARVVVSPSELRLSLVNAFGPHRVVKVDAANTTRECSECHHINTWDAAAELSHTCAQCGARWDQDANAARVIR 
               
               
                 ARGTAASPAPGAARNGDSANDSAAPIESRWAKAKRMRAEKRSGEGGARKPVDAAAE (SEQ ID NO: 88) 
               
               
                   
               
               
                 &gt;3300004174|Ga0066406_1000030_21 
               
               
                 [aquatic-freshwater-freshwater sediment] 
               
               
                 MIRVYKYGIKPPFDFGEDCVDELRRMNNYWNRLVEIDREREVAFRNLCRSWSPEYATAMDRIDALKQPIDAIYEEI 
               
               
                 RATRVKNRNKELPDEIKVRKDRLLGERKVLWETCKAIQKKLPKDLQEPLIQKYKTDCKLARQQSGLYWGNYNAVSE 
               
               
                 SFETAKSRTIKEGGRLHFRLFDGAGRFVNQIQGGMTAVDLFTGAKSQAKCSASVIRKSRGGTPHHSFTFTAFTGRD 
               
               
                 VDGKRFRRELTADLAYHRPIPAEGTIKSIEIVRDIIDGHEKWHVCFTVSLPDIEIEHPKRNIAGVNMGWRQIGSAL 
               
               
                 RIAVIVDDKNQKREYFLPATVAHKFEHAESIQAKADEAENEMLVWLREIYQAANQAPQEWKEAVQGVLRNRPARDA 
               
               
                 YAKLLSEWEGAQDLINGFDEYKAWHKENKKLHRYYAGTRRRAIAWREEIYRSIAKEIAENYAVIAITDTPLSQMSR 
               
               
                 TKSSGGLSIDNALPPAARRNRVIAGIYTLKEWIDKQAAKTGAVVEKITDKVTQTCHKCSAIADKRVGSERYITCTN 
               
               
                 CESELEVDENAAINSRKLASGEVTPKKELRKAAKYQRVREAMNAKNDSARKMADNSSDGVA (SEQ ID NO: 
               
               
                 89) 
               
               
                   
               
               
                 &gt;3300004200|Ga0066422_1000628_7 
               
               
                 [aquatic-freshwater-freshwater sediment] 
               
               
                 MIRVYKYGIKPPFDFGEDCVDELRRMNNYWNRLVEIDREREVAFRNLCRSWSPEYATAMDRIDALKQPIDAIYEEI 
               
               
                 RATRVKNRNKELPDEIKVRKDRLLGERKVLWETCKAIQKKLPKDLQEPLIQKYKTDCKLARQQSGLYWGNYNAVSE 
               
               
                 SFETAKSRTIKEGGRLHFRLFDGAGRFVNQIQGGMTAVDLFTGAKSQAKCSASVIRKSRGGTPHHSFTFTAFTGRD 
               
               
                 VDGKRFRRELTADLAYHRPIPAEGTIKSIEIVRDIIDGHEKWHVCFTVSLPDIEIEHPKRNIAGVNMGWRQIGSAL 
               
               
                 RIAVIVDDKNQKREYFLPATVAHKFEHAESIQAKADEAENEMLVWLREIYQAANQAPQEWKEAVQGVLRNRPARDA 
               
               
                 YAKLLSEWEGAQDLINGFDEYKAWHKENKKLHRYYAGTRRRAIAWREEIYRSIAKEIAENYAVIAITDTPLSQMSR 
               
               
                 TKSSGGLSIDNALPPAARRNRVIAGIYTLKEWIDKQAAKTGAVVEKITDKVTQTCHKCSAIADKRVGSERYITCTN 
               
               
                 CESELEVDENAAINSRKLASGEVTPKKELRKAAKYQRVREAMNAKNDSARKMADNSSDGVA (SEQ ID NO: 
               
               
                 89) 
               
               
                   
               
               
                 &gt;3300004205|Ga0066415_1000057_23 
               
               
                 [aquatic-freshwater-freshwater sediment] 
               
               
                 MIRVYKYGIKPPFDFGEDCVDELRRMNNYWNRLVEIDREREVAFRNLCRSWSPEYATAMDRIDALKQPIDAIYEEI 
               
               
                 RATRVKNRNKELPDEIKVRKDRLLGERKVLWETCKAIQKKLPKDLQEPLIQKYKTDCKLARQQSGLYWGNYNAVSE 
               
               
                 SFETAKSRTIKEGGRLHFRLFDGAGRFVNQIQGGMTAVDLFTGAKSQAKCSASVIRKSRGGTPHHSFTFTAFTGRD 
               
               
                 VDGKRFRRELTADLAYHRPIPAEGTIKSIEIVRDIIDGHEKWHVCFTVSLPDIEIEHPKRNIAGVNMGWRQIGSAL 
               
               
                 RIAVIVDDKNQKREYFLPATVAHKFEHAESIQAKADEAENEMLVWLREIYQAANQAPQEWKEAVQGVLRNRPARDA 
               
               
                 YAKLLSEWEGAQDLINGFDEYKAWHKENKKLHRYYAGTRRRAIAWREEIYRSIAKEIAENYAVIAITDTPLSQMSR 
               
               
                 TKSSGGLSIDNALPPAARRNRVIAGIYTLKEWIDKQAAKTGAVVEKITDKVTQTCHKCSAIADKRVGSERYITCTN 
               
               
                 CESELEVDENAAINSRKLASGEVTPKKELRKAAKYQRVREAMNAKNDSARKMADNSSDGVA (SEQ ID NO: 
               
               
                 89) 
               
               
                   
               
               
                 &gt;3300004565|Ga0066503_104695_4 
               
               
                 [aquatic-freshwater-freshwater sediment] 
               
               
                 MIRVYKYGIKPPFDFGEDCVDELRRMNNYWNRLVEIDREREVAFRNLCRSWSPEYATAMDRIDALKQPIDAIYEEI 
               
               
                 RATRVKNRNKELPDEIKVRKDRLLGERKVLWETCKAIQKKLPKDLQEPLIQKYKTDCKLARQQSGLYWGNYNAVSE 
               
               
                 SFETAKSRTIKEGGRLHFRLFDGAGRFVNQIQGGMTAVDLFTGAKSQAKCSASVIRKSRGGTPHHSFTFTAFTGRD 
               
               
                 VDGKRFRRELTADLAYHRPIPAEGTIKSIEIVRDIIDGHEKWHVCFTVSLPDIEIEHPKRNIAGVNMGWRQIGSAL 
               
               
                 RIAVIVDDKNQKREYFLPATVAHKFEHAESIQAKADEAENEMLVWLREIYQAANQAPQEWKEAVQGVLRNRPARDA 
               
               
                 YAKLLSEWEGAQDLINGFDEYKAWHKENKKLHRYYAGTRRRAIAWREEIYRSIAKEIAENYAVIAITDTPLSQMSR 
               
               
                 TKSSGGLSIDNALPPAARRNRVIAGIYTLKEWIDKQAAKTGAVVEKITDKVTQTCHKCSAIADKRVGSERYITCTN 
               
               
                 CESELEVDENAAINSRKLASGEVTPKKELRKAAKYQRVREAMNAKNDSARKMADNSSDGVA (SEQ ID NO: 
               
               
                   
               
               
                 89) 
               
               
                 &gt;3300009686|Ga0123338_10029047_2 
               
               
                 [aquatic-freshwater-glacier valley] 
               
               
                 MNNSTPTNPSERSEPLAALERVRVVQFGACAPTAGWEAGFLQHRLRTRFWNAICEIERNHRDTVQAIVGPLKEAGM 
               
               
                 PSKDAYASEDVQALELARKGKRLVARQEAAQGGLFWTGYLEVERAMDTARRGLEPPRFKRFEAHEGKLNFLFTNGL 
               
               
                 ASSELCGDDLRVQFEPLELPEGCSARTRKANPYHVKLRVCSQDKKPVWLEFVAYLHRPIPEGSVRDVALIWRREGA 
               
               
                 KQRYSLSVTVREGGVIHAPAPFERAAINIGWKRLTHGLRVAYWRGTDGKHGEIVLSNAWLERYHHALGIESVRAKP 
               
               
                 LNSIKEQMLAYFRTTPDVPEEMATRVTHLAQWRSAARFAVLYKFWVGQRWHGDDAGFNALEAWHKRDVHLWQYGEG 
               
               
                 TSARLMRSRREQYRTFAAKMLERYGEIVMDKLDLRIFAELEARGDDLAPIARAQRVQAAPSTLRLALQNAYGREGR 
               
               
                 VVSWVGARTSSTCHVCRAPVVLGRDLIHTCQGCQSHWDVDDNACSNLLREPEAGIKIPKASRSPRARKNLALGTAV 
               
               
                 GAD (SEQ ID NO: 90) 
               
               
                   
               
               
                 &gt;3300001242|C687J13896_1000006_134 
               
               
                 [aquatic-freshwater-groundwater] 
               
               
                 MKRSKSDKSARVYKFGSPLKTAVESEVAMEQLRLQNRFWNALVEADKVFTEKYWAIRDGADARLPVLRKQIEDIKV 
               
               
                 RTEEIRTEIKKGRQDGIKGTPSDLKAEIVELKAQKKPLIAEKKEIWAFVKDTVKPQLHELDGERYDKNVAIRQEYA 
               
               
                 QNGLYWGNYLAVMDSFETARMAIMKTQVEDGQKRPELQFHRFERVGRWTCQIQGGMNITQAFLGSNNYFQIDRLPA 
               
               
                 DAWTHPSRGERGRLKRTKARIRIGSGEKKTVPIWLEIPIVMHRPIPESAEIKSVSIHVSKLADKFVWSLTVTVRED 
               
               
                 CSVPLERTGHCVAINIGWRAKGLATRIAYMLDSRGVEEEILLGSEYTVSNEKAASLQGIRKKNFNETVAWFNEWKK 
               
               
                 ANADIVPPWLSERTKMMMSWKSEAQLASVAIQWSGRGFRREGDPPEFRFHGDEEAFNKIEAWRKQDKHLWQWHANL 
               
               
                 SDRIRGRRLCEYRKIALKLSKEYDVVIQEDFDLRKTKGKKKAEEGADNDDHIRRMSDLASVSTFRTETIRAMRSAG 
               
               
                 KEHVKLDSKNITKTCPFCGGTIKPGRKTNIMVQCSKCGKVYDQDWAASKNLLTAYLDSSGDVPPETP (SEQ ID 
               
               
                 NO: 91) 
               
               
                   
               
               
                 &gt;3300005236|Ga0066636_10020712_3 
               
               
                 [aquatic-freshwater-groundwater] 
               
               
                 MTRVFEYGLPFDPFDGAELVDEQILLAHRYYNKLIELEHTRRSSILAVQRADPKVGPLLAAYDAANAEVEDLLARK 
               
               
                 REAKSRDRRVAAPELSEIEAAKEARRHLSVQLRKVKKVATDRLKPEYDLAEQATRDAKKAARAASGVFWGTYSLIE 
               
               
                 QAADAAAKAKPVLRPGTHPRPWDQQPSFRRWTGEGMVAVQININRPLNDVTVFGDDLRLRITPVDPAAWSDATSRG 
               
               
                 DRKCLARTNVTMRVGRNTGETATWPMVMHRPLPAGSRVTWAKVLRRRLDDRPHWFKYVLQLTVETADAPRHPGLVS 
               
               
                 LPPAIVAINCGWRALPNGSLRVVTWVGSDGAEGVLDLGCREYRDRIERAESIRSVRDQLRNELTSKLVGIGIDVTR 
               
               
                 WRSFDRFHRLFRELTAEGCERNEAVELLEAWHHRDRHLRQYQDGARGGALRFRREQYRLLAVELARRYPVVCVESW 
               
               
                 DLRPWTDEDRLPGPAAARVEGASSTARLALASAATREGCWLTQIAAHVRLQTQTCHVCGYGAKKGEEWDAAAEL 
               
               
                 VHTCEGCGETWNQDVNFCRNILAASRAAVTEIPELLVPKIMKRSARFAARHKKVAT (SEQ ID NO: 92) 
               
               
                   
               
               
                 &gt;3300014208_Ga0172379_10007070_15 
               
               
                 [aquatic-freshwater-groundwater] 
               
               
                 MRVYRYGLLRPTDEQELGLVREQMRLANKYRNWLVWLERGYRMALSELVDAHPSVAPFLSETEASEVKVDAKEVKI 
               
               
                 RRKRKATRSRSESTEDRQEVATERVSLTERRNALSAARWAALKGPLKAEAKRMNDLWEEMQKETRRQSVCGVFWGT 
               
               
                 SQIQDLAMKESRKALLWYRGKLALPDFVRWSDNQSVGVQVQDNIPPEDLFRQGSLVRIAPVSPQAWSEAVPRGDRK 
               
               
                 RLQRTVLSLRVQSDAKRQPVWAHWPMIMHRAIPAGCVVTRVAVRCRMIGPREEWYATITVDDSKAETAQPCGNGTV 
               
               
                 AMDLGWRAMKGGGIRVARWRDSDGGSGEFQLDEHIVSSLRKAEGLHATRDDNFNEARAKLQKWLAGAPDVPGWLRL 
               
               
                 DTETLGSWRSLERLQALAGKWKKNRFAGDEEGYAALEQWHYHDYHLWQWESDQRAKSLRHRRELYRIFAAKMACRY 
               
               
                 STLVLEDFEIPGVAKKPTVEEDSEYNKNAAHNRQLASPHEFRECMKAAFVARDGMVQLLPCADTTRHCSVCGSLEL 
               
               
                 FDQAKHLWHTCLACEGEGRATTWDQDDNAAQNLLDLWQNGADPVKTVSKALALANKREPAWIKAKRLARAKREADA 
               
               
                 SGAVVQQPTEALEAE (SEQ ID NO: 93) 
               
               
                   
               
               
                 &gt;3300014208|Ga0172379_10014650_2 
               
               
                 [aquatic-freshwater-groundwater] 
               
               
                 MGLVSGIKVYRYGLLAPTENAHLVGEQMWLAHRYQNTLIEIERARRAALRAVYVAHGDVAAMTAVCQAATAEVARL 
               
               
                 YRDAKAARSQSRKRQIPSEIGDALKVAKEASREAQARLRAARLAIKTDPSVVASREQIEERAAWLRRNARAYCGVY 
               
               
                 WGTYLGIESAVSQTAKMPLYDGSEPNDPRFSRWEHEGTVGVQLQGGLAGAGAMRCDDTRLRIEVGTAPKGVDPTSR 
               
               
                 RSATRRYMVLAMRVDSDGRDPVWARWPMKMHRPLPDDAVIKWAHVHRRRRGPHDEWSVTLTIETSAARPAAPTGAV 
               
               
                 GIDLGWRSLDTDGIRVAAWHGSDGRSGTLVLSEWDLSRLEKANDLRSIRDKKFDAARAALSTWLENACVPAWFHEA 
               
               
                 TAHLVQWKSIERLMGLVRRWKGSRFGGDDAAYEALEAWRYNDHHLWAWEAHQRVRALRNRREIYRVFAARMAREYH 
               
               
                 TVVLEDWNISKIAKRPAVDEETVADGNKNSRTARQSVAVSELRLALTHAFGARVEKVPCAFTTRDCHACGSVESWD 
               
               
                 QAAELVHTCSSCGVVWDQDANAAQNLLARFAARGGGDLDNAGTARGNETMNASETLKESRWARAKRVKAERIASDQ 
               
               
                 VARE (SEQ ID NO: 94) 
               
               
                   
               
               
                 &gt;3300014613|Ga0180008_1000021_8 
               
               
                 [aquatic-freshwater-groundwater] 
               
               
                 MIPDGKRKGEKRMILIYEYGIPFDPMEGHDFVEDQILMAHRYYNKLIEIERAKRARIRAIQQAHPILGPLVTESDE 
               
               
                 THELFNDIIDRQKKAKSKDNRYPEVDPEEWEAAKEISAEVRLRLTAAKAAVKAELTPAYEAASQEAKDRKRLARAN 
               
               
                 SKVYWGTYLITEAAAEAAVNAKPKSRPGKVPPPWHMCPAFRRWNGEGSLAVQIQKPKALTEVTVFGHDNQFRITPV 
               
               
                 DPYAWDKSTPRGLRCRLGRTTFTMRVGMKRGETASFRMVMHRPLPPGSRITWAKIIRRRVDDRLYRFRYFLQLTVE 
               
               
                 TTLCVRHPGLDNADPVSIPVVAINCGWRALADGSLRVATWLGSDNRTGTLELGREEFRDRIERAESIRSRRDIDLD 
               
               
                 ELKKAIEGFGEIFKSMEVECVEKWKSFSRFHGLYCDVLTEYAENPTEEKKELLELLTSWHHRDRYLMQYENGCRGG 
               
               
                 ALRFRREKYRLFALELAKAYPVVCIESWDLRRIVEDEHRLKEPSAARVEGASSIARQITRNTSLREGCVVLKQGDK 
               
               
                 EVELATQRCHLCGYGAKKRERWDAAKELVHVCGGCGAEWNQDVNFCENILTTSRGDLVGAPQLLEPKIVIQLGRFQ 
               
               
                 KRAAAKREREAAQADEQEE (SEQ ID NO: 95) 
               
               
                   
               
               
                 &gt;3300014613|Ga0180008_1000021_9 
               
               
                 [aquatic-freshwater-groundwater] 
               
               
                 MIPDETTTSLFAGKLSDPGRNSHRHCSPGNLVIPDGKRKGEKRMILIYEYGIPFDPMEGHDFVEDQILMAHRYYNK 
               
               
                 LIEIERAKRARIRAIQQAHPILGPLVTESDETHELFNDIIDRQKKAKSKDNRYPEVDPEEWEAAKEISAEVRLRLT 
               
               
                 AAKAAVKAELTPAYEAASQEAKDRKRLARANSKVYWGTYLITEAAAEAAVNAKPKSRPGKVPPPWHMCPAFRRWNG 
               
               
                 EGSLAVQIQKPKALTEVTVFGHDNQFRITPVDPYAWDKSTPRGLRCRLGRTTFTMRVGMKRGETASFRMVMHRPLP 
               
               
                 PGSRITWAKIIRRRVDDRLYRFRYFLQLTVETTLCVRHPGLDNADPVSIPVVAINCGWRALADGSLRVATWLGSDN 
               
               
                 RTGTLELGREEFRDRIERAESIRSRRDIDLDELKKAIEGFGEIFKSMEVECVEKWKSFSRFHGLYCDVLTEYAENP 
               
               
                 TEEKKELLELLTSWHHRDRYLMQYENGCRGGALRFRREKYRLFALELAKAYPVVCIESWDLRRIVEDEHRLKEPSA 
               
               
                 ARVEGASSIARQITRNTSLREGCVVLKQGDKEVELATQRCHLCGYGAKKRERWDAAKELVHVCGGCGAEWNQDVNF 
               
               
                 CENILTTSRGDLVGAPQLLEPKIVIQLGRFQKRAAAKREREAAQADEQEE (SEQ ID NO: 96) 
               
               
                   
               
               
                 &gt;3300014656|Ga0180007_10000195_44 
               
               
                 [aquatic-freshwater-groundwater] 
               
               
                 MIPDGKRKGEKRMILIYEYGIPFDPMEGHDFVEDQILMAHRYYNKLIEIERAKRARIRAIQQAHPILGPLVTESDE 
               
               
                 THELFNDIIDRQKKAKSKDNRYPEVDPEEWEAAKEISAEVRLRLTAAKAAVKAELTPAYEAASQEAKDRKRLARAN 
               
               
                 SKVYWGTYLITEAAAEAAVNAKPKSRPGKVPPPWHMCPAFRRWNGEGSLAVQIQKPKALTEVTVFGHDNQFRITPV 
               
               
                 DPYAWDKSTPRGLRCRLGRTTFTMRVGMKRGETASFRMVMHRPLPPGSRITWAKIIRRRVDDRLYRFRYFLQLTVE 
               
               
                 TTLCVRHPGLDNADPVSIPVVAINCGWRALADGSLRVATWLGSDNRTGTLELGREEFRDRIERAESIRSRRDIDLD 
               
               
                 ELKKAIEGFGEIFKSMEVECVEKWKSFSRFHGLYCDVLTEYAENPTEEKKELLELLTSWHHRDRYLMQYENGCRGG 
               
               
                 ALRFRREKYRLFALELAKAYPVVCIESWDLRRIVEDEHRLKEPSAARVEGASSIARQITRNTSLREGCVVLKQGDK 
               
               
                 EVELATQRCHLCGYGAKKRERWDAAKELVHVCGGCGAEWNQDVNFCENILTTSRGDLVGAPQLLEPKIVIQLGRFQ 
               
               
                 KRAAAKREREAAQADEQEE (SEQ ID NO: 95) 
               
               
                   
               
               
                 &gt;3300014656|Ga0180007_10000195_48 
               
               
                 [aquatic-freshwater-groundwater] 
               
               
                 MIPDETTTSLFAGKLSDPGRNSHRHCSPGNLVIPDGKRKGEKRMILIYEYGIPFDPMEGHDFVEDQILMAHRYYNK 
               
               
                 LIEIERAKRARIRAIQQAHPILGPLVTESDETHELFNDIIDRQKKAKSKDNRYPEVDPEEWEAAKEISAEVRLRLT 
               
               
                 AAKAAVKAELTPAYEAASQEAKDRKRLARANSKVYWGTYLITEAAAEAAVNAKPKSRPGKVPPPWHMCPAFRRWNG 
               
               
                 EGSLAVQIQKPKALTEVTVFGHDNQFRITPVDPYAWDKSTPRGLRCRLGRTTFTMRVGMKRGETASFRMVMHRPLP 
               
               
                 PGSRITWAKIIRRRVDDRLYRFRYFLQLTVETTLCVRHPGLDNADPVSIPVVAINCGWRALADGSLRVATWLGSDN 
               
               
                 RTGTLELGREEFRDRIERAESIRSRRDIDLDELKKAIEGFGEIFKSMEVECVEKWKSFSRFHGLYCDVLTEYAENP 
               
               
                 TEEKKELLELLTSWHHRDRYLMQYENGCRGGALRFRREKYRLFALELAKAYPVVCIESWDLRRIVEDEHRLKEPSA 
               
               
                 ARVEGASSIARQITRNTSLREGCVVLKQGDKEVELATQRCHLCGYGAKKRERWDAAKELVHVCGGCGAEWNQDVNF 
               
               
                 CENILTTSRGDLVGAPQLLEPKIVIQLGRFQKRAAAKREREAAQADEQEE (SEQ ID NO: 96) 
               
               
                   
               
               
                 &gt;3300014656|Ga0180007_10004731_7 
               
               
                 [aquatic-freshwater-groundwater] 
               
               
                 MFGHESQPSRIYAYGAKAPVVNGERVGEQIWLGHRYRNTLAEIELRRREQTDKMVVTLSPELPGVEAKLLEADQAI 
               
               
                 ESAAAEIKLANKQARRQKATPEQKTKLAALRKERAALRKKRKALRDVVFSDSGTHDALTGIDQRAAAEQREARAES 
               
               
                 GLYWGTYLTVEQGCQSFRKGRPPRFLRWTGEGRIAVQVQGGLAPEDAFGGEDKRLIVEPLPEDAWSKRSRGLKRTK 
               
               
                 AWLRIGSDDDRQPVWAVVPFVMHRSLPADCRIKWVYLHRRRVGTKDQWMLSFVIARQVWPQTDVAGSGEIGIDLGW 
               
               
                 RLLDHGLRVAAWAGSDGESGELVLPIQDVGRWQKAQDLRGIRDTRLDAVIARFGEWLSGNDAPDWLTERTRTLRQW 
               
               
                 RSAARLASVVLAWRDQRFAGDESIYADLEAWRKKDKHLYEWEANQRRKAVAWLKDLYRNFAAAMARRYRVAVLEAV 
               
               
                 NWRDMGRRAGVGESDKAGAARRQRVIASPGRLAECIRERFADCVSAPAEYTTQRCHACGEIDGFDARVEIVHTCGK 
               
               
                 CGKTWDQDYNAARNLLAFASGPVAKKTR (SEQ ID NO: 97) 
               
               
                   
               
               
                 &gt;3300014656|Ga0180007_10004731_5 
               
               
                 [aquatic-freshwater-groundwater] 
               
               
                 MMFGHESQPSRIYAYGAKAPVVNGERVGEQIWLGHRYRNTLAEIELRRREQTDKMVVTLSPELPGVEAKLLEADQA 
               
               
                 IESAAAEIKLANKQARRQKATPEQKTKLAALRKERAALRKKRKALRDVVFSDSGTHDALTGIDQRAAAEQREARAE 
               
               
                 SGLYWGTYLTVEQGCQSFRKGRPPRFLRWTGEGRIAVQVQGGLAPEDAFGGEDKRLIVEPLPEDAWSKRSRGLKRT 
               
               
                 KAWLRIGSDDDRQPVWAVVPFVMHRSLPADCRIKWVYLHRRRVGTKDQWMLSFVIARQVWPQTDVAGSGEIGIDLG 
               
               
                 WRLLDHGLRVAAWAGSDGESGELVLPIQDVGRWQKAQDLRGIRDTRLDAVIARFGEWLSGNDAPDWLTERTRTLRQ 
               
               
                 WRSAARLASVVLAWRDQRFAGDESIYADLEAWRKKDKHLYEWEANQRRKAVAWLKDLYRNFAAAMARRYRVAVLEA 
               
               
                 VNWRDMGRRAGVGESDKAGAARRQRVIASPGRLAECIRERFADCVSAPAEYTTQRCHACGEIDGFDARVEIVHTCG 
               
               
                 KCGKTWDQDYNAARNLLAFASGPVAKKTR (SEQ ID NO: 98) 
               
               
                   
               
               
                 &gt;3300015370|Ga0180009_10002661_7 
               
               
                 [aquatic-freshwater-groundwater] 
               
               
                 MQAKVYVYGLRPPTHEAERVAEQLHLAHRYRNDLVAIERKRRERVAALLSASGLSAHEERLEAAEQVLEAALSSLR 
               
               
                 AVRQAACKRAETSEQREAVKAARADVKAFREQLKEERKQLRPTLSAETETINDGAADERRAARAVCGVYWGTYLLI 
               
               
                 EQADEQARKSPTPPQFQRWTGEGAVGVQLQGGLDTDTVFGADTRLQIDPVPPTAWDRRRSPERRTRVRLRVGSDGR 
               
               
                 APIWAEWPVTLHRPLPTGEIVWAKVLRQRVEAKSEWGLHLTIRVEDPTPTARSGAVGVDLGWRLREDGLRSGYWVG 
               
               
                 SDGEHGEILVDQRTLDRLQKVKSLCSIRDRNLDELRPWLAEWLRARRAGLPEWLRERTQYLHTWKAPRKFNALSVA 
               
               
                 WRAQRFPGDGEAVERLEAWRKQDKHLWTWETHQRERTLRCRREGYRLLAATLAERYGVLVLEDLDLRVFQQRRPAE 
               
               
                 AEQGECQPARSQQPVAATSILRSCLINAFEAVGGRVVKLDPAGTTKECWLCGGTAWSVQAEESVDRTCRECAALVD 
               
               
                 QDENAGRVLLARFERSGGIAGSADPDTSKSGQLRVSGGRWQRRKERCSKSGTQDCTA (SEQ ID NO: 99) 
               
               
                   
               
               
                 &gt;3300009760|Ga0116131_1003961_2 
               
               
                 [aquatic-freshwater-peatland] 
               
               
                 MKRKTSLVPTKVYRYGLLSPTSNGRLVDETIYRGHQFYNRLIEIERARRAEYRAERTRRFPELATVESLVEDLTKQ 
               
               
                 IETMRTAIVATKIATQSRAVATDSAAELKRLRDERKIAHDRLVEMRAACKSDLDFSAWVKIANEKAYGLVKAARNS 
               
               
                 CGVAWGTYNLIAASAQQASATSTMDPEFRRYDGEGRIGVQIIGGMSVADLATDTQLQIAMPEFHDGMTRGEWRRAS 
               
               
                 RTVVKMRVGSDENRRPIWAEFPAVIHRPLPEDARIMSAVITRRRLGVFRRWEYSLCISCESNKFDRTLPGLKQEGT 
               
               
                 ATINFGWRQFSDGFRVATVNNDVTGIEEIRLPKTITDRFSKCEDLRSIIDMRFNIVRAELQEWLASHKADCPEWLT 
               
               
                 TSLEFLHLWKQPERLDRVVGNWAGLRFAADADIYSILADWRTKYRHLQDWQMMNRRQGLNMRKEFYRLVASRLAQH 
               
               
                 NAKLVVEAFDVRQVAVLPRPEEVASGGTAARHNRFLVAVGNLRSSILLAAQKYHCAVDVVKATNNTRRCNVCGKLL 
               
               
                 DWDPAKTVNRECPECSTWDQDVNATDNAVDRVASGEWTMIAPAELAENGSIRPATKRSWGAARNELDKMPSLL 
               
               
                 (SEQ ID NO: 100) 
               
               
                   
               
               
                 &gt;3300018019|Ga0187874_10017489_1 
               
               
                 [aquatic-freshwater-peatland] 
               
               
                 MSAILVYKFGLLRPVDNATMVHQQVRAAHDYRNDLTMIERGRRAAIRSVLESEPDVAAALTGARAARALLDAALAV 
               
               
                 VASARASARTRAAGAPATGDVKSVRAVLHAAEGTFRQALQAVRTRSHVVSETDRINERAGELGRSARAHCGVYWGT 
               
               
                 YLLIEADMQASRKMPLYDGVEPNDPRYQRWTGKGRLGVQIQKGMSASAVFGADTRIRIDPVNERAWPATSTLGWSE 
               
               
                 RRRLQHTTLHLRVSSDGAAPIWAAWPMSMHRPFPEGARIKGAVVNLRRVAGREEWTVCITLDVTDTQRAQCCGEGA 
               
               
                 VAVDLGWRLLCQPQAHNETGLRVGTWRGEDGAAGTMTLSHHWSGGELKARELRSIRDKAFEAARDALAVWLASPGD 
               
               
                 RPAWLAAKTRALGQWRSAHRLAAVAQWWAAHRFDGDAQAFAALETWRYHDHHLWQWETHQRETTLRDRREQYRIFA 
               
               
                 AGLARRYRTLVLEAFDLRKLARLPAPEQVDGEAQAPRSQRQLVAPSELRDALVKAFVARGGEVVEVSAVDSTRICH 
               
               
                 ACGVVELWDQAAELRHTCSACGVEWDQDDNAGANLLTRYRERPSGDETPGPARKAEKTGKEGSKWARAKALRAERD 
               
               
                 TRTGAARKALAKCAE (SEQ ID NO: 101) 
               
               
                   
               
               
                 &gt;3300018025|Ga0187885_10005575_2 
               
               
                 [aquatic-freshwater-peatland] 
               
               
                 MEDVDLQYRMRYSCHNDLVAVELERRYTFRAYRSTLPEYAVVEQPYLELKKQRDAVREEIKLIRQKSRTRVETPEQ 
               
               
                 NARVAALNAELKKQDVFLKIAAKKVSGDLGLVAVGKEADEVAKAATKAILDDYAARGLTWGTRALVVQELQAAKNA 
               
               
                 ERDPKIHPWDNSGRIGLQLQGKNLSEEMVASGKHIASEQKRLRAMTKELGKKSKVVESFAERLLKMKQDRYAQKTP 
               
               
                 ENRGLPISGLADDTRLQIVVPPEIAYQAASTRRGDRRRAARTTMKMRIGSTPKNAPIWMECKVTMHRQLPADGIIK 
               
               
                 WAWIRKKMLGTHEIYHLQLIIEAPSFEQKIAVADRMEAIAVDVGWRVREKNVLRIAYLVDTAGNRKEILLPTSIVE 
               
               
                 KLKHADSLRGKEDDAFNAIQDRLMEWIGLNKPILPAWFQDTFQFLAQSRSSKNLAWNVREWGRRRFAGDTLIYEEM 
               
               
                 TAWRRQFLHLYEWETNERAKAMGERKNFFRHVGLDLARSAHNVLLEDFKLAKIVENAQPEEDDDNPQTQRHNRVMS 
               
               
                 AISEFRQAIASACSAWRSTLWKLPAAYTTQDCHACHQEKDKHSKWDAAPAIVHTCQEKCGKTWDQDYNASMNLLGA 
               
               
                 WLRSRRTNRAA (SEQ ID NO: 102) 
               
               
                   
               
               
                 &gt;3300018025|Ga0187885_10005575_1 
               
               
                 [aquatic-freshwater-peatland] 
               
               
                 MVRKSTEDPTRIWSFRITEITSPMEDVDLQYRMRYSCHNDLVAVELERRYTFRAYRSTLPEYAVVEQPYLELKKQR 
               
               
                 DAVREEIKLIRQKSRTRVETPEQNARVAALNAELKKQDVFLKIAAKKVSGDLGLVAVGKEADEVAKAATKAILDDY 
               
               
                 AARGLTWGTRALVVQELQAAKNAERDPKIHPWDNSGRIGLQLQGKNLSEEMVASGKHIASEQKRLRAMTKELGKKS 
               
               
                 KVVESFAERLLKMKQDRYAQKTPENRGLPISGLADDTRLQIWPPEIAYQAASTRRGDRRRAARTTMKMRIGSTPK 
               
               
                 NAPIWMECKVTMHRQLPADGIIKWAWIRKKMLGTHEIYHLQLIIEAPSFEQKIAVADRMEAIAVDVGWRVREKNVL 
               
               
                 RIAYLVDTAGNRKEILLPTSIVEKLKHADSLRGKEDDAFNAIQDRLMEWIGLNKPILPAWFQDTFQFLAQSRSSKN 
               
               
                 LAWNVREWGRRRFAGDTLIYEEMTAWRRQFLHLYEWETNERAKAMGERKNFFRHVGLDLARSAHNVLLEDFKLAKI 
               
               
                 VENAQPEEDDDNPQTQRHNRVMSAISEFRQAIASACSAWRSTLWKLPAAYTTQDCHACHQEKDKHSKWDAAPAIVH 
               
               
                 TCQEKCGKTWDQDYNASMNLLGAWLRSRRTNRAA (SEQ ID NO: 103) 
               
               
                   
               
               
                 &gt;3300018057|Ga0187858_10035455_2 
               
               
                 [aquatic-freshwater-peatland] 
               
               
                 MSAILVYKFGLLRPVDNATMVHQQVRAAHDYRNDLTMIERGRRAAIRSVLESEPDVAAALTGARAARALLDAALAV 
               
               
                 VASARASARTRAAGAPATGDVKSVRAVLHAAEGTFRQALQAVRTRSHVVSETDRINERAGELGRSARAHCGVYWGT 
               
               
                 YLLIEADMQASRKMPLYDGVEPNDPRYQRWTGKGRLGVQIQKGMSASAVFGADTRIRIDPVNERAWPATSTLGWSE 
               
               
                 RRRLQHTTLHLRVSSDGAAPIWAAWPMSMHRPFPEGARIKGAWNLLRRVAGREEWTVCITLDVTDTQRAQCCGEGA 
               
               
                 VAVDLGWRLLCQPQAHNETELRVGTWRGEDGAAGTMTLSHHWSGGELKARELRSIRDKAFEAARDALAVWLASPGD 
               
               
                 RPAWLAAKTRALGQWRSAHRLAAVAQWWAAHRFDGDAQAFAALETWRYHDHHLWQWETHQRETTLRDRREQYRIFA 
               
               
                 AGLARRYRTLVLEAFDLRKLARLPAPEQVDGEAQAPRSQRQLVAPSELRDALVKAFVARGGEVVEVSAVDSTRICH 
               
               
                 ACGVVELWDQAAELRHTCSACGVEWDQDDNAGANLLTRYRERLGGDETPGPARKAEKTGKEGSKWARAKALRAERD 
               
               
                 TRTGAARKALAKCAE (SEQ ID NO: 104) 
               
               
                   
               
               
                 &gt;3300012183|Ga0136624_1011435_1 
               
               
                 [aquatic-freshwater-polar desert sand] 
               
               
                 MSTLVYAYGCAPNTPICEEVDEQLHLAHEFYNKLVELEIRHENALDAMWREYPDIASMMDQIDTTDLIITELKKRG 
               
               
                 KAERVENVSTVTSEPLALELKRAKRGQKETRAALRTAKNRIKEDVALPKKHLLAEHQARAKAARIDFAHRGLYWGT 
               
               
                 YNRVWADMKVAVEGVIRKRTGGEPARLHFRRWDGTGTLAVQLQRQDGDPPRDPQGLAEGTTKWRNVFSVAPWMPPA 
               
               
                 EFDSMTRPAQLRIAEQGRVRMNVGASRVVKIPVLVHRMLPPDADVLGASLTVTRVAGRRRASVSVIVNLPDAAPVG 
               
               
                 DDGPRVSVTLGWSSVPHGIQVAKLSADRPLRIPADIADLVHRGPDPHTTEITVPAAWCNRLDSAMGLQSRRDTALD 
               
               
                 AIRSELVEYLRAHPDTSDRPITTTEVARWKAPARFAAVALRWRNNPPLPHGKMIAATLEAWRRTDRRRWEAETHTR 
               
               
                 RRALGCRRDGYRRVAAWLARECSEVTMSSTDLSKLAHRTEVGASASNAVPEEVAQLARQQRVLVAPSELRESIVAA 
               
               
                 CRREGVSVASGAVRAPVSENARSA (SEQ ID NO: 105) 
               
               
                   
               
               
                 &gt;3300012682|Ga0136611_10000100_4 
               
               
                 [aquatic-freshwater-polar desert sand] 
               
               
                 MKSTLNWCYGAKTPDIEQAVSDAIFAAHTYRNQLCALELEKRARHYQVLVELSPDYVAACDAVTLVEVAAQAVEDL 
               
               
                 ITAEKVTQRTQTPKNIKHLRDRATALAAELQVKRAVRKVAQCSAYAMPAVIAALDRSTAQHKAARKQAKQASGLYW 
               
               
                 GTEATVTESCRDFHKGPPPTFKRYDGTGQLSVQLQGGLDCADAERYNTLCYLGDSLGGKRRECFIRIGSDNRAPVF 
               
               
                 ACVPIVFHRALPAGEIKRAYLERRKIASHVRWTIRFTIDIERDIPDRPMPGEVAIHTGWRMEEGSLRVATWLASDG 
               
               
                 STGTLRLSQEHCADYLRLDSLEANRAAGLNEVIAELRTWAKSRELPEFLTEVKPHLHLWKSQARLAKLVWHWAEAR 
               
               
                 FDGDSAMFERLDSWRKTDKHLWQHHRRLTVRISRRRRDAYRVFAKSLSERYGVAILAPIQVQKLTKKPTETRPPED 
               
               
                 WELDQTQSRRHAAWAAVSDLTSCIRERFPLRCITVSSVNMTKECVNCGEINKADGRKIQCRGCGQTYDCDDNAVAN 
               
               
                 TLARGDAALLDGALLALVTEQELKEAAKQAKLVKLQEANNAARTTRQTDL (SEQ ID NO: 106) 
               
               
                   
               
               
                 &gt;3300013127|Ga0172365_10004082_5 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MFGHTSDPSLIFRYGALPPVEDGPVLEQMRAAHRYRNKLVEIERDRREKAAAIVSAASPDLAGLERQYAELGEQVE 
               
               
                 SAAAEIKATNQRARKQRATLEQRAKLRTLRAERAEVYARLKEAKHTAYHSLAARAALDQLDAVTLDATKAARATCS 
               
               
                 VYWGTYLQIEAGLGSIRKGPPPRFLRWTGDGKLAVQIQGGMSRQEAEVGDSRLKIATLERRGKATNVYLRIGTDEM 
               
               
                 RNPIWAIVPVIFHRPIPDDAQIKWVYLLARRVGTHTRWAVCFVLSRATGWGKPDLATDGAVGLDLGWRILDHGLRV 
               
               
                 AYWCGSDGAGEEIVLPLRDVSRWQKADDLRAIRGKNFDAARDELALWLAGRDLPDWLIEQTRALRQWRNATRLAAL 
               
               
                 AIHWREDRFTGDEEAFAPLEAWRTQDKHLLEWEANQRRKAVAWRDDFYRRVAADLSRRYKTLVIEDCNWREMGRLP 
               
               
                 EVGESNESGRAGSYRVIAAVGSLARVLRERFAETVSADPAYTTQRCHVCGQLAQAETRTSVWVKCNHCGEAWDQDR 
               
               
                 NAALNLLSAASGAVT (SEQ ID NO: 107) 
               
               
                   
               
               
                 &gt;3300013127|Ga0172365_10004082_3 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MIFRYGALPPVEDGPVLEQMRAAHRYRNKLVEIERDRREKAAAIVSAASPDLAGLERQYAELGEQVESAAAEIKAT 
               
               
                 NQRARKQRATLEQRAKLRTLRAERAEVYARLKEAKHTAYHSLAARAALDQLDAVTLDATKAARATCSVYWGTYLQI 
               
               
                 EAGLGSIRKGPPPRFLRWTGDGKLAVQIQGGMSRQEAEVGDSRLKIATLERRGKATNVYLRIGTDEMRNPIWAIVP 
               
               
                 VIFHRPIPDDAQIKWVYLLARRVGTHTRWAVCFVLSRATGWGKPDLATDGAVGLDLGWRILDHGLRVAYWCGSDGA 
               
               
                 GEEIVLPLRDVSRWQKADDLRAIRGKNFDAARDELALWLAGRDLPDWLIEQTRALRQWRNATRLAALAIHWREDRF 
               
               
                 TGDEEAFAPLEAWRTQDKHLLEWEANQRRKAVAWRDDFYRRVAADLSRRYKTLVIEDCNWREMGRLPEVGESNESG 
               
               
                 RAGSYRVIAAVGSLARVLRERFAETVSADPAYTTQRCHVCGQLAQAETRTSVWVKCNHCGEAWDQDRNAALNLLSA 
               
               
                 ASGAVT (SEQ ID NO: 108) 
               
               
                   
               
               
                 &gt;3300013127|Ga0172365_10033732_1 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MAICKVYRYGLLPPTENRDLVLKTLRLAHEYRNKLVEIDRQERAEIRAVQTSHGSIPALAAAAKSAIQAKETAYQA 
               
               
                 IKAHKAQDRTRKVPEPLKATYEAAKAAASAASQALWQARAALRGDPTVAIRRDEISLRYNEKRKAARAASGIYHGT 
               
               
                 YMRVEAADQQARKMTPLWDGVEPSDVKFARWRGDGGVGLQMKEKPGPADLPTSRWCRIEPRGAPKGADPSSKRSAK 
               
               
                 RRHCTLALRVGSEEREPVWARWPMVMHRPLPEDGEILWVTVTLRHVGPRQEWVALFTVRHEDKRQVPPAEPVDRVG 
               
               
                 VDIGWRKLEGGGVRVAAWRTDSGAEGELVLDEHMLGQLRKADDLRSIRDKNLDAARASLVAAMPGMSLPDWFPKNV 
               
               
                 WQWRAPARFSNLAKRWKQNRFPGDDLPYAQLEAWRYHDHHLWAWETSQRTKALRHRLDVYRVFAARMARTYTGLVI 
               
               
                 EDWDMRDTAEKPDAHEQEGDNEQARSNRVKSAVSELRRALVQAFVNVAKVPAAYTTQTCSACGAIEKWDQAAELEH 
               
               
                 TCSACGAQWDQDYNAARNLLAYVEQPGGPDNGGVARDEKKPNDGAEVQESKWAKAKRMGKEKRDRVDTARNTVPSA 
               
               
                 AE (SEQ ID NO: 109) 
               
               
                   
               
               
                 &gt;3300013128|Ga0172366_10016188_4 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MFGHTSDPSLIFRYGALPPVEDGPVLEQMRAAHRYRNKLVEIERDRREKAAAIVSAASPDLAGLERQYAELGEQVE 
               
               
                 SAAAEIKATNQRARKQRATLEQRAKLRTLRAERAEVYARLKEAKHTAYHSLAARAALDQLDAVTLDATKAARATCS 
               
               
                 VYWGTYLQIEAGLGSIRKGPPPRFLRWTGDGKLAVQIQGGMSRQEAEVGDSRLKIATLERRGKATNVYLRIGTDEM 
               
               
                 RNPIWAIVPVIFHRPIPDDAQIKWVYLLARRVGTHTRWAVCFVLSRATGWGKPDLATDGAVGLDLGWRILDHGLRV 
               
               
                 AYWCGSDGAGEEIVLPLRDVSRWQKADDLRAIRGKNFDAARDELALWLAGRDLPDWLIEQTRALRQWRNATRLAAL 
               
               
                 AIHWREDRFTGDEEAFAPLEAWRTQDKHLLEWEANQRRKAVAWRDDFYRRVAADLSRRYKTLVIEDCNWREMGRLP 
               
               
                 EVGESNESGRAGSYRVIAAVGSLARVLRERFAETVSADPAYTTQRCHVCGQLAQAETRTSVWVKCNHCGEAWDQDR 
               
               
                 NAALNLLSAASGAVT (SEQ ID NO: 107) 
               
               
                   
               
               
                 &gt;3300013128|Ga0172366_10018111_5 
               
               
                 [aquatic-freshwater-sediment ] 
               
               
                 MSGEEFLLDQLRARVDYWNRLVEIERDFQAEKEQLLSAASAEMEQLATYIALTDGKLTEALSAGARARSQARTRRT 
               
               
                 PEPLAAEIAELRDRLRELRKQYREVRRTTFGNEKVKAALRTLGSERTAVIRKARREHVLKGLWWGNYLDVELAYKT 
               
               
                 ARQKAGSRLRFQRTGPEGRVSVWFQHGLPTSDVWGKDSRLTIARVPEEAWTSDVRSVRRRLARTRVWLRAGSNPDR 
               
               
                 SPRLIEAEMVMHRPLPHGLIRHASIIRERIASHYRHRLVITVAVQDIPTRDGREVGIDIGWRLFEDRLRVAVAVDE 
               
               
                 ENQLEELSLPQEMLGGFAQVRDLQAVRDTHFNGAKAMLAAFLHTAQMPDWLRDATSTLTQWRSQGRLTALALQWRD 
               
               
                 RRFKDDAVYAMLEAWRKRDKHLWEWQANLRDKLLARRREMYRLWAISIARRYGTVVIEEFDLRRIVSEDNIDVADR 
               
               
                 MRFIAALSQLRSILEHTCAREGVRIVKVPASYTTQDCAFCANREQFDARKEVRHRCSKCGAEWDQDENAARNLLKR 
               
               
                 AKGSQVSRKEV (SEQ ID NO: 110) 
               
               
                   
               
               
                 &gt;3300013129|Ga0172364_10001281_26 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MAVEAQFRAAQWYRNRLIEITNKSREKYQQLMLRIPEIARLQETIDADKALKESLREEIKVASAKARKNVPLRPGL 
               
               
                 REQIASLTKAIKENALTLRAAKDKAKAQIAEETNALYAETAAEQKALYNEAGQPGEIVHRKEGHPDIREPRVPLAW 
               
               
                 GTRLLMNKAHEQACSTGMPLKVRHDPVGRIGVQLQKGRTISQIFSGKDGFLRIEPVPDDTWDPRPQNAPKKGERLT 
               
               
                 REQHKARKGTGGKTKSRTRVHLNIGEGRGEDRPFATFPITLYNRKLPVDGKVLWAWILRERIGTRMEYKLQLSVES 
               
               
                 NTFKCESDGHGAIAFDIGWRVRSKNNLRIAYWFDDYGQSGEILLPEIIPSGLAKADSLQAIRKRKFNRMRALLSKA 
               
               
                 KADAIKTGMAIPPALLTETETLSAWRSEDRLRRLVKHIWPNHRFAGDERWFNIAKNWLHKELHLYQWECDERQQAI 
               
               
                 ARRTNFYRHTALEFARKYQTCVFENFKLTRIAVKEPVESEKADTPSNIQHNRVVSALSDFRDAFKNKMIFAKVPME 
               
               
                 FTTIVCHNCRHPEKFNAAKELIRTCPKCNTTWDQDLNAAKNILSRFHCEGTSGTDMGVQAA (SEQ ID NO: 
               
               
                 111) 
               
               
                   
               
               
                 &gt;3300013129|Ga0172364_10017363_4 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MFGHTSDPSLIFRYGALPPVEDGPVLEQMRAAHRYRNKLVEIERDRREKAAAIVSAASPDLAGLERQYAELGEQVE 
               
               
                 SAAAEIKATNQRARKQRATLEQRAKLRTLRAERAEVYARLKEAKHTAYHSLAARAALDQLDAVTLDATKAARATCS 
               
               
                 VYWGTYLQIEAGLGSIRKGPPPRFLRWTGDGKLAVQIQGGMSRQEAEVGDSRLKIATLERRGKATNVYLRIGTDEM 
               
               
                 RNPIWAIVPVIFHRPIPDDAQIKWVYLLARRVGTHTRWAVCFVLSRATGWGKPDLATDGAVGLDLGWRILDHGLRV 
               
               
                 AYWCGSDGAGEEIVLPLRDVSRWQKADDLRAIRGKNFDAARDELALWLAGRDLPDWLIEQTRALRQWRNATRLAAL 
               
               
                 AIHWREDRFTGDEEAFAPLEAWRTQDKHLLEWEANQRRKAVAWRDDFYRRVAADLSRRYKTLVIEDCNWREMGRLP 
               
               
                 EVGESNESGRAGSYRVIAAVGSLARVLRERFAETVSADPAYTTQRCHVCGQLAQAETRTSVWVKCNHCGEAWDQDR 
               
               
                 NAALNLLSAASGAVT (SEQ ID NO: 107) 
               
               
                   
               
               
                 &gt;3300013129|Ga0172364_10018773_2 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MSGEEFLLDQLRARVDYWNRLVEIERDFQAEKEQLLSAASAEMEQLATYIALTDGKLTEALSAGARARSQARTRRT 
               
               
                 PEPLAAEIAELRDRLRELRKQYREVRRTTFGNEKVKAALRTLGSERTAVIRKARREHVLKGLWWGNYLDVELAYKT 
               
               
                 ARQKAGSRLRFQRTGPEGRVSVWFQHGLPTSDVWGKDSRLTIARVPEEAWTSDVRSVRRRLARTRVWLRAGSNPDR 
               
               
                 SPRLIEAEMVMHRPLPHGLIRHASIIRERIASHYRHRLVITVAVQDIPTRDGREVGIDIGWRLFEDRLRVAVAVDE 
               
               
                 ENRLEELSLPQEMLGGFAQVRDLQAVRDTHFNGAKAMLAAFLHTAQMPDWLRDATSTLTQWRSQGRLTALALQWRD 
               
               
                 RRFKDDAVYAMLEAWRKRDKHLWEWQANLRDKLLARRREMYRLWAISIARRYGTVVIEEFDLRRIVSEDNIDVADR 
               
               
                 MRFIAALSQLRSILEHTCAREGVRIVKVPASYTTQDCAFCANREQFDARKEVRHRCSKCGAEWDQDENAARNLLKR 
               
               
                 AKGSQVSRKEV (SEQ ID NO: 112) 
               
               
                   
               
               
                 &gt;3300013129|Ga0172364_10045136_2 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MAICKVYRYGLLPPTENRDLVLKTLRLAHEYRNKLVEIDRQERAEIRAVQTSHGSIPALAAAAKSAIQAKETAYQA 
               
               
                 IKAHKAQDRTRKVPEPLKATYEAAKAAASAASQALWQARAALRGDPTVAIRRDEISLRYNEKRKAARAASGIYHGT 
               
               
                 YMRVEAADQQARKMTPLWDGVEPSDVKFARWRGDGGVGLQMKEKPGPADLPTSRWCRIEPRGAPKGADPSSKRSAK 
               
               
                 RRHCTLALRVGSEEREPVWARWPMVMHRPLPEDGEILWVTVTLRHVGPRQEWVALFTVRHEDKRQVPPAEPVDRVG 
               
               
                 VDIGWRKLEGGGVRVAAWRTDSGAEGELVLDEHTLGQLRKADDLRSIRDKNLEAARAALVAAMPGMSLPNWFPKNV 
               
               
                 WQWRAQARFSNLAKRWKQNRFPGDDLPYAQLEAWRYHDHHLWAWETSQRTKALRHRLDVYRVFAARMARTYTGLVI 
               
               
                 EDWDMRDTAEKPDAHEQEGDNEQARSNRVKSAVSELRRALVQAFVNVAKVPAAYTTQTCSACGAIEKWDQAAELEH 
               
               
                 TCSACGAQWDQDYNAARNLLAYVEQPGGPDNGGVARDEKKPNDGAEVQESKWAKAKRMGKEKRDRVDTARNTVPSA 
               
               
                 AE (SEQ ID NO: 113) 
               
               
                   
               
               
                 &gt;3300013130|Ga0172363_10000480_22 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MAVEAQFRAAQWYRNRLIEITNKSREKYQQLMLRIPEIARLQETIDADKALKESLREEIKVASAKARKNVPLRPGL 
               
               
                 REQIASLTKAIKENALTLRAAKDKAKAQIAEETNALYAETAAEQKALYNEAGQPGEIVHRKEGHPDIREPRVPLAW 
               
               
                 GTRLLMNKAHEQACSTGMPLKVRHDPVGRIGVQLQKGRTISQIFSGKDGFLRIEPVPDDTWDPRPQNAPKKGERLT 
               
               
                 REQHKARKGTGGKTKSRTRVHLNIGEGRGEDRPFATFPITLYNRKLPVDGKVLWAWILRERIGTRMEYKLQLSVES 
               
               
                 NTFKCESDGHGAIAFDIGWRVRSKNNLRIAYWFDDYGQSGEILLPEIIPSGLAKADSLQAIRKRKFNRMRALLSKA 
               
               
                 KADAIKTGMAIPPALLTETETLSAWRSEDRLRRLVKHIWPNHRFAGDERWFNIAKNWLHKELHLYQWECDERQQAI 
               
               
                 ARRTNFYRHTALEFARKYQTCVFENFKLTRIAVKEPVESEKADTPSNIQHNRVVSALSDFRDAFKNKMIFAKVPME 
               
               
                 FTTIVCHNCRHPEKFNAAKELIRTCPKCNTTWDQDLNAAKNILSRFHCEGTSGTDMGVQAA (SEQ ID NO: 
               
               
                 111) 
               
               
                   
               
               
                 &gt;3300013130|Ga0172363_10009486_8 
               
               
                 [aquatic-freshwater-sediment ] 
               
               
                 MFGHTSDPSLIFRYGALPPVEDGPVLEQMRAAHRYRNKLVEIERDRREKAAAIVSAASPDLAGLERQYAELGEQVE 
               
               
                 SAAAEIKATNQRARKQRATLEQRAKLRTLRAERAEVYARLKEAKHTVYHSLAARAALDQLDAVTLDATKAARATCS 
               
               
                 VYWGTYLQIEAGLGSIRKGPPPRFLRWTGDGKLAVQIQGGMSRQEAEVGDSRLKIATLERRGKATNVYLRIGTDEM 
               
               
                 RNPIWAIVPVIFHRPIPDDAQIKWVYLLARRVGTHTRWAVCFVLSRATGWGKPDLATDGAVGLDLGWRILDHGLRV 
               
               
                 AYWCGSDGAGEEIVLPLRDVSRWQKADDLRAIRGKNFDAARDELALWLAGRDLPDWLIEQTRALRQWRNATRLAAL 
               
               
                 AIHWREDRFTGDEEAFAPLEAWRTQDKHLLEWEANQRRKAVAWRDDFYRRVAADLSRRYKTLVIEDCNWREMGRLP 
               
               
                 EVGESNESGRAGSYRVIAAVGSLARVLRERFAETVSADPAYTTQRCHVCGQLAQAETRTSVWVKCNHCGEAWDQDR 
               
               
                 NAALNLLSAASGAVT (SEQ ID NO: 114) 
               
               
                   
               
               
                 &gt;3300013130|Ga0172363_10014785_2 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MPRTRSKALPTKVYKYGCSAPLENQELVKEQWRLANRYRNALLENSLQWRSACQAVVSAEDTELRDIDTCIDILNV 
               
               
                 NIDSLISEKKKRNSAARKRLKHPDLEAKITDCKTERKRLYARRKLVKDIAYRSPGNKQALDAVHQAFKAANREARK 
               
               
                 IASKSGLGWGTYLQIEDSAKNFAKGKPAKFKRFDRDAGGSIAIQIQTPQGAPHLTVDRLLEGKDNRLQLIPQPDGI 
               
               
                 HALVRLCVGGVDMSQRRSANNPPCYVTVRMNMHRPLPPDSHITWVKLIARRVGLKLKWDVHFTVARGSGFAPTIGS 
               
               
                 GVVGIDIGYRHLDDGSLRVAAWAGSDGRHGELILPATLVRALTRKQELQALRDEKFNVVRASLVEWCKHVSIPDWL 
               
               
                 KEAASTLALWRSQKRLHTLAQQWSQNRFTGDSSMYIVLDAWRKEDRHHLAWLANESEQGICRRKDIYGKFVAELRR 
               
               
                 HYGTVGLEDIDLREHAQADNLSKGVQNQRSIAAHSTLRSLLSTMQVIKVPAANTTRRCHYCGHINNVGTDVGYYCD 
               
               
                 DCGWTGDRDYNASQNILREATYSLRAGGRSHVAT (SEQ ID NO: 115) 
               
               
                   
               
               
                 &gt;3300013133|Ga0172362_10012573_3 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MFGHTSDPSLIFRYGALPPVEDGPVLEQMRAAHRYRNKLVEIERDRREKAAAIVSAASPDLAGLERQYAELGEQVE 
               
               
                 SAAAEIKATNQRARKQRATLEQRAKLRTLRAERAEVYARLKEAKHTAYHSLAARAALDQLDAVTLDATKAARATCS 
               
               
                 VYWGTYLQIEAGLGSIRKGPPPRFLRWTGDGKLAVQIQGGMSRQEAEVGDSRLKIATLERRGKATNVYLRIGTDEM 
               
               
                 RNPIWAIVPVIFHRPIPDDAQIKWVYLLARRVGTHTRWAVCFVLSRATGWGKPDLATDGAVGLDLGWRILDHGLRV 
               
               
                 AYWCGSDGAGEEIVLPLRDVSRWQKADDLRAIRGKNFDAARDELALWLAGRDLPDWLIEQTRALRQWRNATRLAAL 
               
               
                 AIHWREDRFTGDEEAFAPLEAWRTQDKHLLEWEANQRRKAVAWRDDFYRRVAADLSRRYKTLVIEDCNWREMGRLP 
               
               
                 EVGESNESGRAGSYRVIAAVGSLARVLRERFAETVSADPAYTTQRCHVCGQLAQAETRTSVWVKCNHCGEAWDQDR 
               
               
                 NAALNLLSAASGAVT (SEQ ID NO: 107) 
               
               
                   
               
               
                 &gt;3300013133|Ga0172362_10022806_8 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MPRTRSKALPTKVYKYGCSAPLENQELVKEQWRLANRYRNALLENSLQWRSACQAVVSAEDTELRDIDTCIDILNV 
               
               
                 NIDSLISEKKKRNSAARKRLKHPDLEAKITDCKTERKRLYARRKLVKDIAYRSPGNKQALDAVHQAFKAANREARK 
               
               
                 IASKSGLGWGTYLQIEDSAKNFAKGKPAKFKRFDRDAGGSIAIQIQTPQGAPHLTVDRLLEGKDNRLQLIPQPDGI 
               
               
                 HALVRLCVGGVDMSQRRSANNPPCYVTVRMNMHRPLPPDSHITWVKLIARRVGLKLKWDVHFTVARGSGFAPTIGS 
               
               
                 GVVGIDIGYRHLDDGSLRVAAWAGSDGRHGELILPATLVRALTRKQELQALRDEKFNVVRASLVEWCKHVSIPDWL 
               
               
                 KEAASTLALWRSQKRLHTLAQQWSQNRFTGDSSMYIVLDAWRKEDRHHLAWLANESEQGICRRKDIYGKFVAELRR 
               
               
                 HYGTVGLEDIDLREHAQADNLSKGVQNQRSIAAHSTLRSLLSTMQVIKVPAANTTRRCHYCGHINNVGTDVGYYCD 
               
               
                 DCGWTGDRDYNASQNILREATYSLRAGGRSHVAT (SEQ ID NO: 115) 
               
               
                   
               
               
                 &gt;3300013133_Ga0172362_10025871_2 
               
               
                 [aquatic-freshwater-sediment] 
               
               
                 MAICKVYRYGLLPPTENRDLVLKTLRLAHEYRNKLVEIDRQERAEIRAVQTSHGSIPALAAAAKSAIQAKETAYQA 
               
               
                 IKAHKAQDRTRKVPEPLKATYEAAKAAASAASQALWQARAALRGDPTVAIRRDEISLRYNEKRKAARAASGIYHGT 
               
               
                 YMRVEAADQQARKMTPLWDGVEPSDVKFARWRGDGGVGLQMKEKPGPADLPTSRWCRIEPRGAPKGADPSSKRSAK 
               
               
                 RRHCTLALRVGSEEREPVWARWPMVMHRPLPEDGEILWVTVTLRHVGPRQEWVALFTVRHEDKRQVPPAEPVDRVG 
               
               
                 VDIGWRKLEGGGVRVAAWRTDSGAEGELVLDEHTLGQLRKADDLRSIRDKNLEAARAALVAAMPGMSLPNWFPKNV 
               
               
                 WQWRAQARFSNLAKRWKQNRFPGDDLPYAQLEAWRYHDHHLWAWETSQRTKALRHRLDVYRVFAARMARTYTGLVI 
               
               
                 EDWDMRDTAEKPDAHEQEGDNEQARSNRVKSAVSELRRALVQAFVNVAKVPAAYTTQTCSACGAIEKWDQAAELEH 
               
               
                 TCSACGAQWDQDYNAARNLLAYVEQPGGPDNGGVARDEKKPNDGAEVQESKWAKAKRMGKEKRDRVDTARNTVPSA 
               
               
                 AE (SEQ ID NO: 113) 
               
               
                   
               
               
                 &gt;3300010155|Ga0098047_10009758_2 
               
               
                 [aquatic-marine] 
               
               
                 MPVKSKMKGDGRIYAYRASLPTKNLEIVQEQLYLVHKYRNRLVELELNRRSQVDQALRDLVPDLEPTELALKQLDD 
               
               
                 QIAAAKDAQKKANIKQRGRKVAKSDRDALKDLKAQRKVLYQKRKQLRKDTFSSTAWKSRQTQIENNAKVESKAARA 
               
               
                 SCGLYWGSYAPVEEAARAFRRGAPPRFHRWTGEGKLAVQMQAQAGKPDFTPDTLTSCSSNLLRLELRPEGIWVDGK 
               
               
                 RRPKKLGNALLWFRVGSTTVKPKRQPIWAEVPIKLHRPLPSDCKIKWCYLQRRKRGTKTIWEVCFVLQGEHGAFDP 
               
               
                 GDQASEGHVGIDVGWRKYEDRLRIAVYSGSDGQEGELCLPDWWLGESRRVERIRGHRDKLLDAAKTELKAWIKGRE 
               
               
                 SLPDWLTEAGKHMHQWRSASRLAGLCLRWRGELIKPTTDGAAALASLEAWRERDKHLYEYEAHLRAQLQGSRKDLY 
               
               
                 RKFAAMLSRKYATAYIEDLDLRKFHQLRAIEEGGDKGTDSIRAYVRDACLSELFDAIKSRFRHHVKVDPANTTKQC 
               
               
                 HACSVVDASWVDHAKVDHECSSCSVTWDQDTNAARNLLNSGDEPVTQFGGPALAPVLVHTYTHKGPNRARRRARRR 
               
               
                 RALEKKRLNDAA (SEQ ID NO: 116) 
               
               
                   
               
               
                 &gt;3300006805|Ga0075464 10026824 2 
               
               
                 [aquatic-marine-aqueous] 
               
               
                 MRVYKYRAYAPIVGAGIFDAQSRARHRYQNQLIEIERAWCGLDRATKKDPEAQARRKALVKAARQDAARRGLAWGS 
               
               
                 YNGASDDVRRAVSALRGAARDEGPRFRRFDGGGRIKVQQQPGARVVVIDGDRVTFRLGHQGAVTVPVVMHRPIPPD 
               
               
                 ATIKEAQLHRERVADKYKWWVTITVAVPAPPPAPPRGVVGIDLGWARRGGKSERDGRRVAVASFADGRELQVRCPE 
               
               
                 SILAKIDHARGLRSLRDVKFNVAIAWLREHVCEHGAPEWLRAALRWSHAWRSQAKLAAVVLRWRDARYDGDDGIYQ 
               
               
                 TLEIWRRRDKHLWTWEVHETRKALAQRREIYRVAAAYIAEHAGEVRVEDIDLAEMAESDDLPRAARRGRVDTAPST 
               
               
                 FLAAVKNACSSRGVTYAVVSAKNTTRKCSGCGVVGRSVVGDTFACGGCGLVADRDANAARNIAASAPEAPREPKPK 
               
               
                 SADLRRAGKARHDAARAAAVKAA (SEQ ID NO: 117) 
               
               
                   
               
               
                 &gt;3300006805|Ga0075464 10026824 2 
               
               
                 [aquatic-marine-aqueous] 
               
               
                 MDVRVYKYRAYAPIVGAGIFDAQSRARHRYQNQLIEIERAWCGLDRATKKDPEAQARRKALVKAARQDAARRGLAW 
               
               
                 GSYNGASDDVRRAVSALRGAARDEGPRFRRFDGGGRIKVQQQPGARVVVIDGDRVTFRLGHQGAVTVPVVMHRPIP 
               
               
                 PDATIKEAQLHRERVADKYKWWVTITVAVPAPPPAPPRGVVGIDLGWARRGGKSERDGRRVAVASFADGRELQVRC 
               
               
                 PESILAKIDHARGLRSLRDVKFNVAIAWLREHVCEHGAPEWLRAALRWSHAWRSQAKLAAVVLRWRDARYDGDDGI 
               
               
                 YQTLEIWRRRDKHLWTWEVHETRKALAQRREIYRVAAAYIAEHAGEVRVEDIDLAEMAESDDLPRAARRGRVDTAP 
               
               
                 STFLAAVKNACSSRGVTYAVVSAKNTTRKCSGCGVVGRSVVGDTFACGGCGLVADRDANAARNIAASAPEAPREPK 
               
               
                 PKSADLRRAGKARHDAARAAAVKAA (SEQ ID NO: 118) 
               
               
                   
               
               
                 &gt;3300009149|Ga0114918_10020022_2 
               
               
                 [aquatic-marine-deep subsurface] 
               
               
                 MGGKAGTVKTAKKHKHRWVEDLEKDLIENCSCGKSRKSQNSSVIVYGLGKPMFDEEGSECPSCNEESNGEPCGAHR 
               
               
                 FIDQMRLGHSYGNKLTELYRASSERYREIIGSASKKMEVIVMKLDDLDDQIKGLNALLKADKDNKEAKKLKKELTA 
               
               
                 DRKIIRADRKELVEKLKQNKIIQARLKKNNIKLNSEIIKARGEFSKLGLMWGTYNLHEASAKQAQYAPGRRGDPEF 
               
               
                 KRWEGHGRIGVQLQGGLPESKVWGDSRSFQIDKVDHETWSKLREDGSPDRAFRRKQCRTKVRVRIGSAKAKPIWVE 
               
               
                 FPMTMHRPIPEGADIRDVTILQKKSGTIYRYSLHVQINENKTNQPERSGVVGVNLGWRKHQDNTLRVAYWYGDDGR 
               
               
                 YGEYLLDSEYLEKVKVMDGKQSKRSMALDVIKETFAVWLDGQDNLPEWIQEWRGIKFIRDWRSSSRLASLVLRWRK 
               
               
                 NRFDGDALIFENLEEWRRADKHTCNQEGGIRNKNQLRRQDEYRNFAAFLARTYGKVVVDDTNYANLARKPGPEDDD 
               
               
                 NKVARKQANLASPGKLRVNIKNACHKHGAIYVAASSKHITATCHKCGTINDWDKSLSLTHWCSGCNAFWDQDMNAA 
               
               
                 INLCRSGGGKPPNFEHPGDARIELNDEVNKYDWLIQESAGMAGSKKQPIENLAVTL (SEQ ID NO: 119) 
               
               
                   
               
               
                 &gt;3300006083|Ga0081762_1007854_6 
               
               
                 [aquatic-marine-diffuse hydrothermal flow volcanic vent] 
               
               
                 MRERARNWPVMVFSYGILPSFLKEEAAINILKEEAYRMNELWNKLVEIGRKYLETYSSNIEEDPAIAPLISQRKEI 
               
               
                 ENTLEETDKQIKQLRIKLKTKKHPALAELEEKKRELRRQLREIKASIRETKKQVKEKYREVFAQMEEEVKEAVKKA 
               
               
                 PLYWCNKEVVRDKFWAAWRGVKNGNIPKFHRFDDRWCLTWRFTGGGMPVKDAFRKVLSGIVPPEVYKLPTKKRNKM 
               
               
                 ANLTCLFRQGEYRILVPIILHRPLPEGGYIKRVTFVRRPYGRDRVRLFLNFTVEVPPDKYYLPVREERKGKIAALE 
               
               
                 LGFRKVDGRIRVGVLYDPFTEEKFREIFIPQNIPERLEKVRKGQSKADEELEDIKNDLSKWLVEPQVLPKLPEEIK 
               
               
                 KLITNRVAWVKTRDRGVWKVINLLKESGADPAAARNVERRMLKREKFLNDLQRTRIKALGARKRFYENLAKEIFDR 
               
               
                 YEMLIIKDISLKKLALKEMAEQLPDEARWVRFVAALGELVGCLERRAERTKGVLVKLDPAYLTRTCHICNHINNPN 
               
               
                 RPEKLFWTCEKCGTKWDQDKNAAVNLYEQGIERLKLAQTG (SEQ ID NO: 120) 
               
               
                   
               
               
                 &gt;3300010354|Ga0129333_10000304_8 
               
               
                 [aquatic-marine-freshwater to marine saline gradient] 
               
               
                 MRLGHRYQNDLIAIERGRRLAFAAVMSSDTRIAEAEAKITEIDAKISEAVERARQARVARRTKADTEQTKSEIRSL 
               
               
                 KASKAAAVLDLRAIKPLVQSELRPRIAEVDARAHELQISARAHCGVYWGTYLLAEAAAEQAAKTTKGELRFQRWDG 
               
               
                 SGQVSVQIQGGADVDDVVGDSDTRLRWPEYVEGTRKAKRTELAMRVSSEKGVPVWARWPMVYHRPLPTNARIKRAI 
               
               
                 VSLRMRGPREEWSVEVTIDASTCRLRDRPDGGKVAVHLGWRKEPSGNVRVATWLGDDGDAGTIECPERVLTGFAKC 
               
               
                 ESLRSIRDRNLDELRARLVLAREGWPVWLRDATSSLYQWRSPGRFVALAQRWKAAGVAPEHASDYGAIEAWRYNDH 
               
               
                 HLWRWEHDQRLNSTRYRREVYRIAVAELSRRYRRAILMAADWAEMAKLPGIGEGAPDLPDEARAQRVETAPYVLTE 
               
               
                 ALHSAMTEVVWVDPSYLSQACRHCDHKDTGDTWVRECTSCGKARDIDEAAVRTMLDLEEAGAWSWKKGGAKDESGK 
               
               
                 VREIRAPKWAKKHATEAAE (SEQ ID NO: 121) 
               
               
                   
               
               
                 &gt;3300010354|Ga0129333_10000304_10 
               
               
                 [aquatic-marine-freshwater to marine saline gradient] 
               
               
                 MTTRVYRYGLLAPTENSELVRQQMRLGHRYQNDLIAIERGRRLAFAAVMSSDTRIAEAEAKITEIDAKISEAVERA 
               
               
                 RQARVARRTKADTEQTKSEIRSLKASKAAAVLDLRAIKPLVQSELRPRIAEVDARAHELQISARAHCGVYWGTYLL 
               
               
                 AEAAAEQAAKTTKGELRFQRWDGSGQVSVQIQGGADVDDVVGDSDTRLRWPEYVEGTRKAKRTELAMRVSSEKGVP 
               
               
                 VWARWPMVYHRPLPTNARIKRAIVSLRMRGPREEWSVEVTIDASTCRLRDRPDGGKVAVHLGWRKEPSGNVRVATW 
               
               
                 LGDDGDAGTIECPERVLTGFAKCESLRSIRDRNLDELRARLVLAREGWPVWLRDATSSLYQWRSPGRFVALAQRWK 
               
               
                 AAGVAPEHASDYGAIEAWRYNDHHLWRWEHDQRLNSTRYRREVYRIAVAELSRRYRRAILMAADWAEMAKLPGIGE 
               
               
                 GAPDLPDEARAQRVETAPYVLTEALHSAMTEVVWVDPSYLSQACRHCDHKDTGDTWVRECTSCGKARDIDEAAVRT 
               
               
                 MLDLEEAGAWSWKKGGAKDESGKVREIRAPKWAKKHATEAAE (SEQ ID NO: 122) 
               
               
                   
               
               
                 &gt;3300009507|Ga0115572_10029017_2 
               
               
                 [aquatic-marine-pelagic marine] 
               
               
                 MISRVYKYGAVPLKKFPEVKFPREQFPEEGVEELRRANKLRNSLVWLHRKNNEKFEAARVAADAEYGEIAEKLDAL 
               
               
                 EKTISQALTAKRQARAKAGTRDAKHPLVKAASETINELTKQRSDLWKALKPARIRADKRVDRKALTKQFDDAVKVV 
               
               
                 QHVKETGGLSSHCANEIVRYFKESRSRALNERATLRYRRFDGTGFWFYRFREPGVNKNGVDFDGLLTGNKTEARDN 
               
               
                 RNFVLTEKSRRGKRVIYKLRAKIAGGAKKDSKVYGHFDLILHRPIPENARIQSAKILRHRTGDKFTYTVSFTLKLP 
               
               
                 DVEQQTVEGSVLGLDIGFREMERNNSYRIATLATNDQSRRVETIDIARENRRGFLARMNHIDDLRSTMDENATELG 
               
               
                 KKLLPLLKTAKPLPDSHQQFIFTERLRKTRANVTLDFERSYKMARWFIRAPDEADFYGPEIVGMVLRWWEENSFKY 
               
               
                 REMHNLRRKALAERKEVYRMEAARLVGFGIPIAVEKLDMSKWAERKDSDNELSNRALSSRFLVAPSELIAAIENAA 
               
               
                 KREGVPFIKVNAANTSKACHACGTINKALKGELIWTCEECETKHDRDINAAINIAKRGILQAKKEKKQ (SEQ ID 
               
               
                 NO: 123) 
               
               
                   
               
               
                 &gt;3300017963_Ga0180437_10000100_151 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MTKTYVYGLPLGPTVNADLVEEQMRLAHKYRNALIEIERERREKVREVYDERDLALEGLVEEDKVAKSELKRATED 
               
               
                 LKRQRAKTRSRSDTAEQRARVKEARKAAQEVAKRLSEARKELKLDEELQKRLSEANLTASEKSQAAQQGFSREGLF 
               
               
                 WGTYLQVDNAMEDSRRDLKMWDEHGQPLDPKFLQWRGDGTVAVQLQGDKHPVEKIFSGEDTFLQVDMEPPPEGVVS 
               
               
                 KTRRKKRRGVMRLRVGSTKSRGPVWAEFPIIMHRPLPQGVRIKWAVVKRRMISDRPRWTVHFSLGLPAEYQHEEFG 
               
               
                 SGRGAVAVDIGWRKRGEDQIRVAYLVDGDEYAAYLRDRQDPLGRGDELLMEPEVVRGFDKVESLQSIRALNQNEMQ 
               
               
                 KSLKGWIKSNKKNLPEWFREDVRYLHSWKSPKRYAGLLRKWGEKRWDGDGEGFQILKDWLSGTYEESLGRRDGGDR 
               
               
                 HLWQWKESQEQKSLRRRKDHYRRVAAKLARKYKVLVIEDFKLTETQKHEPPESEKVEIQAARNQQKEAACYELRMM 
               
               
                 FVQAFLARGGTVVWVDARMTTQRCFECGCLEPWDAIPEVDHVCVECGAKWDQDANAARNIMRLYRNDETLKMIDGS 
               
               
                 VPVEPKMSRRQKGRKKGKKIVQQRKSQEAAQPSV (SEQ ID NO: 124) 
               
               
                   
               
               
                 &gt;3300017963|Ga0180437_10000153_25 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MTRKTSKTKRKKKPGKPRVRGPQLAYVYGLPFGPTKNAELVEKQIVLSQRYNNQCVEAERRLRATLREIYQQHTLD 
               
               
                 LMGASDEMREAFTEVKRLEKLLREMQEDLRTKRKRSRSRSDTPQERMRLREVRDLKNEAWAKLRELKNGSESDDEP 
               
               
                 GKEEPRKKVELSDELKARRAEAQQREKQELHEAYVQFKDGTYEKVTETDEELGKLYWGTYLLVNRAREASRMSLRD 
               
               
                 SLWKWNEEKGIWVERDPKFKSLDDEVIFGVELQKGDSVERVLNCQNTMFQLDMEPEMGEEVLRHRRIRRRGIARIR 
               
               
                 VGSGGKSGRDPIWAEFPVIMHRPLPPKARIKWAVVKREKITTRLRWTLHLHLEVDSGDCHKDYGTGRGVVAVDIGW 
               
               
                 RKRGTETVEMGRKRKKRGLRKQEVEVPRIRIAYLIDDREYAAYLKNPDEGEVGHEQCMSSKVVAGFQRVETLQQTR 
               
               
                 QLKQNEMLAELRAWIKARRSALPKWFRESTRGIAKWEAPKRFAWLLRLWRESRWKGDERGFEILDRWQRGVYDEEA 
               
               
                 RRLEGGDRHLWQWQESQRRKSLLQREDHYRCVDSALAREFKVLVLENIDLSKMQKHELPGSDKVEIRRARRQQKEA 
               
               
                 ALSEFRETLIQAFLSRGGTVVWVNPAMTTQRCFDCGHDAPWDPIPKVEHTCEKCGRTWDQDANAARNMMRLYRENK 
               
               
                 IVKIADGSVLVREMSDAQKNRNKGKKVVRKRKKEEEERNGEGPAPLES (SEQ ID NO: 125) 
               
               
                   
               
               
                 &gt;3300017963|Ga0180437_10000488_78 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MRVYKYGLLRPTTNADLVHEQIKIGHKYRNKLIELEIKRRDLIRAEVAKSSVVEDDFTDAKLAVEKFKHLDKLLKQ 
               
               
                 KNAQHRSKRHNNPDLKKDHTKARKEKTKAIKKLEETRRKVLKKCKETIKVFNDQYIEEEKKVRSECAPFWGTYQVI 
               
               
                 EDAMKRSRKSLPLWDGLESNNPKFRRFNGIGRVSIQLQKDVIDKNNGMNVDLVFGTTDTRLQVAPVPEEAWYSPIR 
               
               
                 SVRRKKSRTVLKMRIGSEGRAPIWAEWPMIMHRPLPDNGRIKRVTVNFRKIGPREEWTADFFINDSATLHEQYEVS 
               
               
                 GAIGLDVGWRLMDDGSLRVAFWEDDEGEKGEFRLSPTLMGAFKKADDLRSIRDKNRDEIKEFLIQHFSKNPMPSWM 
               
               
                 LDFVKGKEDSKRPTNKQACVYLSKWKSIAKLTKLVQTWKEKGITKRHQKAYNRFEDWRYHDFHLWQWETSQRKKAE 
               
               
                 RRRKDNYRVLASKLSKQYHTLVLENFDLRKVARKKAADDDSLDIKAANHNRFVANISELRLVLRNAFEKCGEIELV 
               
               
                 KAVNTTKICFWCGFINNFDQAKNLIHQCYSCGVVWDQDDNASTNIRRRRKQG (SEQ ID NO: 126) 
               
               
                   
               
               
                 &gt;3300017963|Ga0180437_10000692_13 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MGAARRRNPKVAAARKGKPPPKATGNCRNYRYGAHEPIANLDKVLDEMRGAHDLRNVLTCINRARSEMITAALGEH 
               
               
                 QSYKKATADLAALHQRRDKLEAQIRQQNSASRKRLGRHSPLSSELDTVRKRIDEGRTALKKLRRKLLKKDPALKAV 
               
               
                 VEAADDMAKRETTRAEDACGLYWCTRNEQTGKRAKLRRFKKWRDSEATISVQIPGGLTVEQLLGGENNQARLELRP 
               
               
                 EGVWVQGARKRKVEPAEAARNKLRLDEDGYPMRKLGTAILHLRCMSDEDGKPIWAEVPITYHREIPADAKIKRCYL 
               
               
                 HRFRVGNRYHWSVRFSLERGKKGDDSWLHPRVATTGTAAIDIGWRWFPDRLRVAVWAGSDGAEGELCLPKWWLDEM 
               
               
                 YSVRLDQRERDVLFNEIVSLVLPWFRSRRGELSDYVVQAIKTMHSWRDKGRLAALSMRWRDDLAADPGANPAHVAM 
               
               
                 SIRLEEWRKRDKHIWCEEVNLRSQLQGSRKDLYRRFAAMLTSRYGRIVVEEFDLSAVQKLPPASIDDGTYSRVKRH 
               
               
                 KGDAACSHLVGALKDAARQLDKKNPKWTTKRCHVCGKTERKWENPGELEHTCKHCGVLWDRDVNAARNILAASGVA 
               
               
                 VDWTRPPLAPAARMTYPQVENREMRRSRRRKEALETTRASGDRQTA (SEQ ID NO: 127) 
               
               
                   
               
               
                 &gt;3300017963|Ga0180437_10006965_20 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MLKRGERGERGERGERGERGERGASMPRNPKKKMDGVGRNYKYGAYAPLTNEDEVRWQMVLGHRYRNRLVEVELDI 
               
               
                 RAKRDAIIQEVAPGLLALEDEINKMGEIIALHEKAQKEQNKKQRGRDVHPGVANLLRDLKAEKKGLVGKRKALKAE 
               
               
                 LFASDRWKQDGGDHLNQQRKEGRSNAYSEYKDEGLWWGVRSKILRESGSFISGAPPKFRGWHKSVRSTRFVVQTQG 
               
               
                 GLTEEELLSGRNTTARLTLFPDGVWAEGKRRPKRMGDAILDLRIGSDEHRKPIWTSIPISYDRHLPAEAKIKWIYL 
               
               
                 FKRLLVDKEKWEVVFALECPAAADYDAIRRRGGDKKRTNRNRKGIRLRKYAQSGVVAIDVGWRKFEDYLLVGTCAA 
               
               
                 SDGREWELRLDGNWLGQLRRVEGMQSYRDVLLNEQVKWLHPWLKSRKGSLPELLLPPSRNLEKWGQRSVARLVKQW 
               
               
                 MRERPIGTLDEQRALARLDEWLSRENHVWHFQANLQHQLLLYRREEYRVWARRIGEVYRCVVLEKLNYGDWHKKPP 
               
               
                 VERGGSVKADMAKKYLRDAGLSHLKNALKGGVLQVADVPHEGTTVNCHACGHADVWEDPAAKDHVCETCGLRWDRD 
               
               
                 VNAARNILAASGVTVAWEREPLAPTEAWTACSKSGLNRAQRRAISSSLAIDSEIALAVGGSE (SEQ ID NO: 
               
               
                 128) 
               
               
                   
               
               
                 &gt;3300017963|Ga0180437_10006965_20 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MPRNPKKKMDGVGRNYKYGAYAPLTNEDEVRWQMVLGHRYRNRLVEVELDIRAKRDAIIQEVAPGLLALEDEINKM 
               
               
                 GEIIALHEKAQKEQNKKQRGRDVHPGVANLLRDLKAEKKGLVGKRKALKAELFASDRWKQDGGDHLNQQRKEGRSN 
               
               
                 AYSEYKDEGLWWGVRSKILRESGSFISGAPPKFRGWHKSVRSTRFVVQTQGGLTEEELLSGRNTTARLTLFPDGVW 
               
               
                 AEGKRRPKRMGDAILDLRIGSDEHRKPIWTSIPISYDRHLPAEAKIKWIYLFKRLLVDKEKWEVVFALECPAAADY 
               
               
                 DAIRRRGGDKKRTNRNRKGIRLRKYAQSGVVAIDVGWRKFEDYLLVGTCAASDGREWELRLDGNWLGQLRRVEGMQ 
               
               
                 SYRDVLLNEQVKWLHPWLKSRKGSLPELLLPPSRNLEKWGQRSVARLVKQWMRERPIGTLDEQRALARLDEWLSRE 
               
               
                 NHVWHFQANLQHQLLLYRREEYRVWARRIGEVYRCVVLEKLNYGDWHKKPPVERGGSVKADMAKKYLRDAGLSHLK 
               
               
                 NALKGGVLQVADVPHEGTTVNCHACGHADVWEDPAAKDHVCETCGLRWDRDVNAARNILAASGVTVAWEREPLAPT 
               
               
                 EAWTACSKSGLNRAQRRAISSSLAIDSEIALAVGGSE (SEQ ID NO: 129) 
               
               
                   
               
               
                 &gt;3300017963|Ga0180437_10073069_2 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MGNVPLLEQQTKEAGERVSEASKSVKQYRSKNRTRKVPEWMRTELDAARLAKKDVAAKLREVRKQLRTPEIQAEMD 
               
               
                 RINGLAGELRRSARAHCGLYWGSYLLVEDEMASSSKSPLYDKENPNEPNDPGFVRWHGEGHLGVQIQGGMPTGLVQ 
               
               
                 FHSTLLQIKKVDPVEGKLGKSHYLLRMRVGSNGRKPIWGEWPMVMHRPLDPGQIKGAAVSCRRIGLRWQWTVEITV 
               
               
                 DKESGCRPRPCGYGQVAVNFGWRKVDGGIRVAYAVDYEGNEQELVLPDGEAEGIVRPSRVRERLTDEQRAIQKRDG 
               
               
                 IIYGKACRLSDDGKSYEAEKVLSGRPDLLSRLSSRVRPARKPPILPALRKSDELRSIRDQRFGHILQSLIKWLKTI 
               
               
                 EVPCWLKDRTSHIHKWKSQNRLRKLIGYWRSNRFDGDETMFQSLEVWNHRDEHLLSWEDSQRKKSQRRRRDLYRVW 
               
               
                 AAKLADRYYTIVLNSHDMAETARKPKVEATDDIPLSRSNRQLVSPSELKEALINAKRSREGQTVENPAQKVTHTCH 
               
               
                 NCETEQDFDAASSIEHTCLACGETWDQDRNAAINSLRWFVERPSDAKILGTARKIKNLDENGVEKETRRQRISRLK 
               
               
                 REKDARMKALANDAASS (SEQ ID NO: 130) 
               
               
                   
               
               
                 &gt;3300017971|Ga0180438_10000090_91 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MTRKTSKTKRKKKPGKPRVRGPQLAYVYGLPFGPTKNAELVEKQIVLSQRYNNQCVEAERRLRATLREIYQQHTLD 
               
               
                 LMGASDEMREAFTEVKRLEKLLREMQEDLRTKRKRSRSRSDTPQERMRLREVRDLKNEAWAKLRELKNGSESDDEP 
               
               
                 GKEEPRKKVELSDELKARRAEAQQREKQELHEAYVQFKDGTYEKVTETDEELGKLYWGTYLLVNRAREASRMSLRD 
               
               
                 SLWKWNEEKGIWVERDPKFKSLDDEVIFGVELQKGDSVERVLNCQNTMFQLDMEPEMGEEVLRHRRIRRRGIARIR 
               
               
                 VGSGGKSGRDPIWAEFPVIMHRPLPPKARIKWAVVKREKITTRLRWTLHLHLEVDSGDCHKDYGTGRGVVAVDIGW 
               
               
                 RKRGTETVEMGRKRKKRGLRKQEVEVPRIRIAYLIDDREYAAYLKNPDEGEVGHEQCMSSKWAGFQRVETLLQQTR 
               
               
                 QLKQNEMLAELRAWIKARRSALPKWFRESTRGIAKWEAPKRFAWLLRLWRESRWKGDERGFEILDRWQRGVYDEEA 
               
               
                 RRLEGGDRHLWQWQESQRRKSLLQREDHYRCVDSALAREFKVLVLENIDLSKMQKHELPGSDKVEIRRARRQQKEA 
               
               
                 ALSEFRETLIQAFLSRGGTVVWVNPAMTTQRCFDCGHDAPWDPIPKVEHTCEKCGRTWDQDANAARNMMRLYRENK 
               
               
                 IVKIADGSVLVREMSDAQKNRNKGKKVVRKRKKEEEERNGEGPAPLES (SEQ ID NO: 125) 
               
               
                   
               
               
                 &gt;3300017971|Ga0180438_10000124_114 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MGAARRRNPKVAAARKGKPPPKATGNCRNYRYGAHEPIANLDKVLDEMRGAHDLRNVLTCINRARSEMITAALGEH 
               
               
                 QSYKKATADLAALHQRRDKLEAQIRQQNSASRKRLGRHSPLSSELDTVRKRIDEGRTALKKLRRKLLKKDPALKAV 
               
               
                 VEAADDMAKRETTRAEDACGLYWCTRNEQTGKRAKLRRFKKWRDSEATISVQIPGGLTVEQLLGGENNQARLELRP 
               
               
                 EGVWVQGARKRKVEPAEAARNKLRLDEDGYPMRKLGTAILHLRCMSDEDGKPIWAEVPITYHREIPADAKIKRCYL 
               
               
                 HRFRVGNRYHWSVRFSLERGKKGDDSWLHPRVATTGTAAIDIGWRWFPDRLRVAVWAGSDGAEGELCLPKWWLDEM 
               
               
                 YSVRLDQRERDVLFNEIVSLVLPWFRSRRGELSDYVVQAIKTMHSWRDKGRLAALSMRWRDDLAADPGANPAHVAM 
               
               
                 SIRLEEWRKRDKHIWCEEVNLRSQLQGSRKDLYRRFAAMLTSRYGRIVVEEFDLSAVQKLPPASIDDGTYSRVKRH 
               
               
                 KGDAACSHLVGALKDAARQLDKKNPKWTTKRCHVCGKTERKWENPGELEHTCKHCGVLWDRDVNAARNILAASGVA 
               
               
                 VDWTRPPLAPAARMTYPQVENREMRRSRRRKEALETTRASGDRQTA (SEQ ID NO: 127) 
               
               
                   
               
               
                 &gt;3300017971|Ga0180438_10000195_144 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MTKTYVYGLPLGPTVNADLVEEQMRLAHKYRNALIEIERERREKVREVYDERDLALEGLVEEDKVAKSELKRATED 
               
               
                 LKRQRAKTRSRSDTAEQRARVKEARKAAQEVAKRLSEARKELKLDEELQKRLSEANLTASEKSQAAQQGFSREGLF 
               
               
                 WGTYLQVDNAMEDSRRDLKMWDEHGQPLDPKFLQWRGDGTVAVQLQGDKHPVEKIFSGEDTFLQVDMEPPPEGVVS 
               
               
                 KTRRKKRRGVMRLRVGSTKSRGPVWAEFPIIMHRPLPQGVRIKWAVVKRRMISDRPRWTVHFSLGLPAEYQHEEFG 
               
               
                 SGRGAVAVDIGWRKRGEDQIRVAYLVDGDEYAAYLRDRQDPLGRGDELLMEPEVVRGFDKVESLQSIRALNQNEMQ 
               
               
                 KSLKGWIKSNKKNLPEWFREDVRYLHSWKSPKRYAGLLRKWGEKRWDGDGEGFQILKDWLSGTYEESLGRRDGGDR 
               
               
                 HLWQWKESQEQKSLRRRKDHYRRVAAKLARKYKVLVIEDFKLTETQKHEPPESEKVEIQAARNQQKEAACYELRMM 
               
               
                 FVQAFLARGGTVVWVDARMTTQRCFECGCLEPWDAIPEVDHVCVECGAKWDQDANAARNIMRLYRNDETLKMIDGS 
               
               
                 VPVEPKMSRRQKGRKKGKKIVQQRKSQEAAQPSV (SEQ ID NO: 124) 
               
               
                   
               
               
                 &gt;3300017971|Ga0180438_10013386_7 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MRVYKYGLLRPTTNADLVHEQIKIGHKYRNKLIELEIKRRDLIRAEVAKSSVVEDDFTDAKLAVEKFKHLDKLLKQ 
               
               
                 KNAQHRSKRHNNPDLKKDHTKARKEKTKAIKKLEETRRKVLKKCKETIKVFNDQYIEEEKKVRSECAPFWGTYQVI 
               
               
                 EDAMKRSRKSLPLWDGLESNNPKFRRFNGIGRVSIQLQKDVIDKNNGMNVDLVFGTTDTRLQVAPVPEEAWYSPIR 
               
               
                 SVRRKKSRTVLKMRIGSEGRAPIWAEWPMIMHRPLPDNGRIKRVTVNFRKIGPREEWTADFFINDSATLHEQYEVS 
               
               
                 GAIGLDVGWRLMDDGSLRVAFWEDDEGEKGEFRLSPTLMGAFKKADDLRSIRDKNRDEIKEFLIQHFSKNPMPSWM 
               
               
                 LDFVKGKEDSKRPTNKQACVYLSKWKSIAKLTKLVQTWKEKGITKRHQKAYNRFEDWRYHDFHLWQWETSQRKKAE 
               
               
                 RRRKDNYRVLASKLSKQYHTLVLENFDLRKVARKKAADDDSLDIKAANHNRFVANISELRLVLRNAFEKCGEIELV 
               
               
                 KAVNTTKICFWCGFINNFDQAKNLIHQCYSCGVVWDQDDNASTNIRRRRKQG (SEQ ID NO: 126) 
               
               
                   
               
               
                 &gt;3300017971|Ga0180438_10021273_1 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MPRNPKKKMDGVGRNYKYGAYAPLTNEDEVRWQMVLGHRYRNRLVEVELDIRAKRDAIIQEVAPGLLALEDEINKM 
               
               
                 GEIIALHEKAQKEQNKKQRGRDVHPGVANLLRDLKAEKKGLVGKRKALKAELFASDRWKQDGGDHLNQQRKEGRSN 
               
               
                 AYSEYKDEGLWWGVRSKILRESGSFISGAPPKFRGWHKSVRSTRFVVQTQGGLTEEELLSGRNTTARLTLFPDGVW 
               
               
                 AEGKRRPKRMGDAILDLRIGSDEHRKPIWTSIPISYDRHLPAEAKIKWIYLFKRLLVDKEKWEVVFALECPAAADY 
               
               
                 DAIRRRGGDKKRTNRNRKGIRLRKYAQSGVVAIDVGWRKFEDYLLVGTCAASDGREWELRLDGNWLGQLRRVEGMQ 
               
               
                 SYRDVLLNEQVKWLHPWLKSRKGSLPELLLPPSRNLEKWGQRSVARLVKQWMRERPIGTLDEQRALARLDEWLSRE 
               
               
                 NHVWHFQANLQHQLLLYRREEYRVWARRIGEVYRCVVLEKLNYGDWHKKPPVERGGSVKADMAKKYLRDAGLSHLK 
               
               
                 NALKRGVLQVADVPHEGTTVNCHACGHADVWEDPAAKDHVCETCGLRWDRDVNAARNILAASGVTVAWEREPLAPT 
               
               
                 EAWTACSKSGLNRAQRRAISSSLAIDSEIALAVGGSE (SEQ ID NO: 131) 
               
               
                   
               
               
                 &gt;3300017971|Ga0180438_10044179_5 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MIVYQYGLRAPTSQIELIHDQLWLSHRYRNTLVEIERGRRAAVRRLNSTVGNVPLLEQQTKEAGERVSEASKAVKQ 
               
               
                 YRSKNRTRKVPEWMRTELDAARLEKKDVATKLREVRKQLRTPEIQAEMDRINGLAGELRRSARAHCGLYWGSYLLV 
               
               
                 EDEMASSSKSPLYDKENPNEPNDPGFVRWHGEGHLGVQIQGGMPTGLVQFHSTLLQIKKVDPVEGKLGKSHYLLRM 
               
               
                 RVGSNGRKPIWGEWPMVMHRPLDPGQIKGAAVSCRRIGLRWQWTVEITVDKESGCRPRPCGYGQVAVNFGWRKVDG 
               
               
                 GIRVAYAVDYEGNEQELVLPDGEAEGIVRPSRVRERLTDEQRAIQKRDGLIYGKACRLSDDGKSYEAEKVLSGRPD 
               
               
                 LLSRLSSRVRPARKPPILPALRKSDELRSIRDQRFGHILQSLIKWLKTIEVPCWLKDRTSHIHKWKSQNRLRKLIG 
               
               
                 YWRSNRFDGDETMFQSLEVWNHRDEHLLSWEDSQRKKSQRRRRDLYRVWAAKLADRYYTIVLNSHDMAETARKPKV 
               
               
                 EATDDIPLSRSNRQLVSPSELKEALINAKRSREGQTVENPAQKVTHTCHNCETEQDFDAASSIEHTCLACGETWDQ 
               
               
                 DRNAAINSLRWFVERPSDAKILGTARKIKNLDENGVEKETRRQRISRLLKREKDARMKALLANDAASS (SEQ ID 
               
               
                 NO: 132) 
               
               
                   
               
               
                 &gt;3300017971|Ga0180438_10056790_2 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MSRFHKDRLKVDAKIFSFNASEPMEGLEVIRSEMKLAHDYYNKLVELERARRSEIEEEQLRRFPELLRIEEEIAVA 
               
               
                 EDSLVDLVRETKRRNSSRRSAKLPKEDRERIKIARGVLRELCKRRSEMKKGLRENADYQEAEKGITKKAKGAAKEA 
               
               
                 RHESGCFWPNYLQVEVAVESAKKPRKRRKGQRPVRWTYRPRFKRWEGRGRVSMQLQKGLSPERLESGADTRLRLVR 
               
               
                 GRVTKPGPRRERKQGTAMLWIRVGSTKEPGKRAQPVWAKVPFYYGGKRDRELPPDCSIKWCWLLVDKIGLKERWRV 
               
               
                 QFSIDAPLGTLKHVDRASDGTVAIDIGWRLMGDRLRCAIWSGSDGEEGEIALTGSWVRAYSRERAMRSYRERLFNC 
               
               
                 VLKELCSWAKEQEVLPEPLAEARALHAWKKHGKLASLSLKWRGKRDFRERSEKAASYLREGGVVDLSGASEDDVLA 
               
               
                 LLEGWRKRDKHVLEYESHLRDKLQATRLDLYRVCVANLRRRYKTCVLEEDVEDDERTKLMDLVKWHLLPDVIEAGD 
               
               
                 PGEEEQRRASKRGLRPACLFKLRAILKENMEIVGVPSEFTTKRCWSCGSVEEWDQASEVEHTCENCGETWDQDVNA 
               
               
                 ARNLLVASGVEATFFRPALAPAEVWTCGLRGTFPEPV (SEQ ID NO: 133) 
               
               
                   
               
               
                 &gt;3300017971|Ga0180438_10072596_2 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MFGHDSLPSRIYRYGAKAPTVGAENVDRQMSLGHRYYNTLVEIERRRREKAAALVARVSPALASLEQRREALTAAI 
               
               
                 AERREAVKKSNQEVRKKQATKDERDAIAALTAERKEVNVLYRDAKDLAYNSPEAAAGLAAIDQQADMEAKTARAES 
               
               
                 GLYWGTYLQVEQSLPRKGPPPKFHRWMGDGKIAVQIQGGMTLEEAFAGRDQRFRLEPIPDNAWDKGNRKHRRTRAW 
               
               
                 IRVASDGRDPVWAVVPVVLHRPIPDDAQIKWVYLLRRRVGCNNNWSLCLVISRQAWQRHDLAGDGAVGINLGWRKV 
               
               
                 EGGIRVATWVGDDDESDTLVISERDAGRWQKAKDLRSIRDGRFNAIQEALVDWLGSHAVPEWFSERTATIKQWRSQ 
               
               
                 ARLAALVIAWRSQRFEGDEGIFPAMEAWRKKDKHLYEWEANQRRKAVAWRNDLYRCFAAKLSQRYETAVLGKTDWK 
               
               
                 TIGRRPSPENPEHASGGENRTLASPGILQRMIVERVARVELADAKHITQRCHACGKLASFDARTNIFTTCRHCAET 
               
               
                 WDQDENAARNLLLSASGPVAQKTP (SEQ ID NO: 134) 
               
               
                   
               
               
                 &gt;3300017987|Ga018043l_10022214_3 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MRVIVYEYGLRQPTSGIDDIDDQIHRAHRYYNKLIEIERWRRAQVKKAQLQVPEVANTKKVVEALREDLEALRTQH 
               
               
                 KRAKSHDGKTHPPRAGAIKDTTAALKAARQGYRQAKKDAADILKPLYKKVDEERNALVRQARGESGVYWGTYLCIE 
               
               
                 QFASQAAQTAKRESPDFRRWTGDGMLAVQIQNGLDAGALFGDDTRVQVAPIDSKAWDKSISRGKRKRMQYTTLRLR 
               
               
                 VGSTGPGNREPVWAEWPLFMHRELPADASIKWVRVIRRRWDQRWKYRWVVQFTVEVPEAPGWQGEGTRKGMVAINL 
               
               
                 GWRKLATDALRVATWVDTEGNVGELQLPVSFRQRLEKANSIRSIRDRKLDELKAAIVPLLPECSRWKSPKRFEGLL 
               
               
                 RQDDLPDGVRDLVNKWAYRDRHLWWFERGCRQGALRYRREIYRLFALEMAKKYPLVIVEDYDLRPIVTDENRIKLP 
               
               
                 SHQRVEGSPSEARHVLLASVSRLGGMVIDGKSKLATQECHLCGYGKEKDERWDASPKIEHTCVGCGENWDQDVNNA 
               
               
                 RVLLARAQVMLESGELLAQPKPKRSARFAKKHKKQNEAVL (SEQ ID NO: 135) 
               
               
                   
               
               
                 &gt;3300017987|Ga0180431_10041976_5 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MFGHDSLPSRIYRYGAKAPTVGAENVDRQMSLGHRYYNTLVEIERRRREKAAALVARVSPALASLEQRREALTAAI 
               
               
                 AERREAVKKTNQEVRKKQATKDERDAIAALTAERKEVNVLYRDAKDLAYNSPEAAAGLAAIDQQADMEAKTARAES 
               
               
                 GLYWGTYLQVEQSLPRKGPPPKFHRWMGDGKIAVQIQGGMTLEEAFAGRDQRFRLEPIPDNAWDKGNRKHRRTRAW 
               
               
                 IRVASDGRDPVWAVVPVVLHRPIPDDAQIKWVYLLRRRVGCNNNWSLCLVISRQAWQRHDLAGDGAVGINLGWRKV 
               
               
                 EGGIRVATWVGDDDESGTLVISERDAGRWQKAKDLRSIRDGRFNAIQEALVDWLGSHAVPEWFSERTATIKQWRSQ 
               
               
                 ARLAALVIAWRSQRFEGDEGIFPAMEAWRKKDKHLYEWEANQRRKAVAWRNDLYRCFAAKLSQRYETAVLGKTDWK 
               
               
                 TIGRRPSPENPEHASGGENRTLASPGILQRMIVERVARVELADAKHITQRCHACGKLASFDARTNIFTTCRHCAET 
               
               
                 WDQDENAARNLLLSASGPAAQKTP (SEQ ID NO: 136) 
               
               
                   
               
               
                 &gt;3300017989|Ga0180432_10002388_5 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MRVIVYEYGLRQPTSGIDDIDDQIHRAHRYYNKLIEIERWRRAQVKKAQLQVPEVANTKKVVEALREDLEALRTQH 
               
               
                 KRAKSHDGKTHPPRAGAIKDTTAALKAARQGYRQAKKDAADILKPLYKKVDEERNALVRQARGESGVYWGTYLCIE 
               
               
                 QFASQAAQTAKRESPDFRRWTGDGMLAVQIQNGLDAGALFGDDTRVQVAPIDSKAWDKSISRGKRKRMQYTTLRLR 
               
               
                 VGSTGPGNREPVWAEWPLFMHRELPADASIKWVRVIRRRWDQRWKYRWVVQFTVEVPEAPGWQGEGTRKGMVAINL 
               
               
                 GWRKLATDALRVATWVDTEGNVGELQLPVSFRQRLEKANSIRSIRDRKLDELKAAIVPLLPECSRWKSPKRFEGLL 
               
               
                 RQDDLPDGVRDLVNKWAYRDRHLWWFERGCRQGALRYRREIYRLFALEMAKKYPLVIVEDYDLRPIVTDENRIKLP 
               
               
                 SHQRVEGSPSEARHVLLASVSRLGGMVIDGKSKLATQECHLCGYGKEKDERWDASPKIEHTCVGCGENWDQDVNNA 
               
               
                 RVLLARAQVMLESGELLAQPKPKRSARFAKKHKKQNEAVL (SEQ ID NO: 135) 
               
               
                   
               
               
                 &gt;3300017989|Ga0180432_10021155_3 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MYRYGLLPPSSGAELVDEQMWLVHRYSNELVEIERARRKGFHAALAVVPEVAEALRVEEEALARYHVLRDSDSDDR 
               
               
                 AAEFRKKGKRRRKSSPAVADALAALKAATDAVEDVRAAAVKAIGRDSKKKKTAKKKKKKKTATELVKMTPAEVASV 
               
               
                 TEAINENDAVHGDAAKRKRAEFIAQGLYWGNYQVAEASIPRKGPPPKFRRWEGRGHIAVQIQGGMTYAELLSCNHT 
               
               
                 MARLEIRDDWGSNRRTSRHGLLWIRVGSKGKGGREPVWATFPVCWHRHLPEGARIKRIDVTRRIQGVRAVWAVCVT 
               
               
                 VQTPGASLTKQALVKPVTKALPKAVGLDVGWRSTDDGGIRVAVLYDGDRHYEVALPHWFAEGDRLVSDLQSIRRCR 
               
               
                 FNAVKDQLLAALREGKHKEQAETFATLASWDSQARLARAVREWEGCPAYLTEWRAKERHLYQWERDAKRYLVEWRK 
               
               
                 NWYCHWVAWISQRYKNVVIEKFDIAKIKKKAEAGEDKEEATGPHSLAAPGELRRILLSTCSREGVQVHLAPAGNTT 
               
               
                 RKCSVCGKLRRKKKGEGVALMQECSGCGRVMDQDANASRNLYGFASAGVIPETPVAFAVPEAAWYGRFSLTPKKIQ 
               
               
                 SRVARLQAALETSPPDSDGKGG (SEQ ID NO: 137) 
               
               
                   
               
               
                 &gt;3300017989|Ga0180432_10021155_5 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MAFHHSTQPTTSRVYRYGLLPPSSGAELVDEQMWLVHRYSNELVEIERARRKGFHAALAVVPEVAEALRVEEEALA 
               
               
                 RYHVLRDSDSDDRAAEFRKKGKRRRKSSPAVADALAALKAATDAVEDVRAAAVKAIGRDSKKKKTAKKKKKKKTAT 
               
               
                 ELVKMTPAEVASVTEAINENDAVHGDAAKRKRAEFIAQGLYWGNYQVAEASIPRKGPPPKFRRWEGRGHIAVQIQG 
               
               
                 GMTYAELLSCNHTMARLEIRDDWGSNRRTSRHGLLWIRVGSKGKGGREPVWATFPVCWHRHLPEGARIKRIDVTRR 
               
               
                 IQGVRAVWAVCVTVQTPGASLTKQALVKPVTKALPKAVGLDVGWRSTDDGGIRVAVLYDGDRHYEVALPHWFAEGD 
               
               
                 RLVSDLQSIRRCRFNAVKDQLLAALREGKHKEQAETFATLASWDSQARLARAVREWEGCPAYLTEWRAKERHLYQW 
               
               
                 ERDAKRYLVEWRKNWYCHWVAWISQRYKNVVIEKFDIAKIKKKAEAGEDKEEATGPHSLAAPGELRRILLSTCSRE 
               
               
                 GVQVHLAPAGNTTRKCSVCGKLRRKKKGEGVALMQECSGCGRVMDQDANASRNLYGFASAGVIPETPVAFAVPEAA 
               
               
                 WYGRFSLTPKKIQSRVARLQAALETSPPDSDGKGG (SEQ ID NO: 138) 
               
               
                   
               
               
                 &gt;3300017989|Ga0180432_10043261_1 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MSTKVYKFRLYAPILNGDLVEEQLKLANAYRNKLIELERDRRVVARELNAERRSVLGEYIDAAEELKTRLKREVNR 
               
               
                 LKAMKAMKARGARKSPELKDQEKLVTQIRQERKAAVEDLKAREANLKTTSELQAKYDKLWEDLTNKTKEERNLNGL 
               
               
                 YWGTGGFQEQAMQKSSETLHLGKDPRFKRWDGCGTVAVQVQKPLQMPLKDFFHGKSTLINFIMDDEGASGTKRHGV 
               
               
                 VQLRVGSDRKKPIWAEWPLVMHREMHERAVITGAQIHKTRTADKFKYHLCVTAKLPDDVRKERCGDGVVALDIGWR 
               
               
                 KLLDGNLRVAYWKDREGNGGQLVLDPAVLSGLGKDASLQAICRGLLNKLYKAFYTWLSSVANLPENFQQIYEEMTA 
               
               
                 EKAYWKEFRALQKIVREARAGGLPELDALEEKLAEMKARQKEVRTWKVQGKFSGLLEDWRNNRWDGDNAGFTMLDD 
               
               
                 WWRGTYNPESGHREGGCKHLWQWRSNQREKSQRRRKHQYRNLGAEFSRKAGVLVLENFDLTDMQRDAEPEEKKKNP 
               
               
                 EAKLNQRYAACYELREAFIQAFQSRGGRWKIDPQMTTQICARCGCDTRWDAALEIEHTCERCGATWDQDENAADN 
               
               
                 LLKLYEGGGSIQEVTVVKKDPRWKRLKAEKAAKLEDRGGARKD (SEQ ID NO: 139) 
               
               
                   
               
               
                 &gt;3300017989|Ga0180432_10045094_6 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MVTEYTTKVYTCGLRPPAENADLVSEQIRLGHRYYNRLIEIEHEKRQRDHEIVGAHGDADALQAAIDEQVVVVEQV 
               
               
                 VARIRRWRIANGKKVASKDLRMELAAAKKSLKAARAELRELRRVIKQDPEIAASRVALWAEDSAARKRARAECGIP 
               
               
                 HGTYIQVEQAVEAACKAPMAPGCETPWWELPRFKRWKGEGCVGLQLQQRDGEYMDTDALFGRSDPRLQIDPVPSTA 
               
               
                 WDRRRSREQRTVVRMRIGSECRRCGALCTSIHCPEGGDGGAAYRSPVWASWPMILHRPLPEGALIKWAKVKRERIV 
               
               
                 GKARWRWSLHLTIDEPEQEPRCGEGTVAVDVGWRKTETGMRVGYWQDDSGDHNSINIDHEILDRLRKVDELESIRK 
               
               
                 RNMNAAKSQLRAWLATWEEVPDWMREASRHMHAWRSQNRLAGLALHWRQNRWEGDNPGYEDLEDWRKQDKHLWAWQ 
               
               
                 DNLRGKVLRRRREVYRVAAARLAERYDTVVLTDFDLRDTQRHPSDTSTREEIDAVKWQQKAAACSVLRGCIRNAFT 
               
               
                 SRGGRIVEVEAKLMSRTCHGCGHDGEWAKPEELEHTCQGCGETWDRDVNSTTNMLRAARERSDDDDGRPKKRAAKW 
               
               
                 AKRHGRSKNENDDDGTSRNAGDKVA (SEQ ID NO: 140) 
               
               
                   
               
               
                 &gt;3300017991|Ga0180434_10002646_1 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MRVIVYEYGLRQPTSGIDDIDDQIHRAHRYYNKLIEIERWRRAQVKKAQLQVPEVANTKKVVEALREDLEALRTQH 
               
               
                 KRAKSHDGKTHPPRAGAIKDTTAALKAARQGYRQAKKDAADILKPLYKKVDEERNALVRQARGESGVYWGTYLCIE 
               
               
                 QFASQAAQTAKRESPDFRRWTGDGMLAVQIQNGLDAGALFGDDTRVQVAPIDSKAWDKSISRGKRKRMQYTTLRLR 
               
               
                 VGSTGPGNREPVWAEWPLFMHRELPADASIKWVRVIRRRWDQRWKYRWVVQFTVEVPEAPGWQGEGTRKGMVAINL 
               
               
                 GWRKLATDALRVATWVDTEGNVGELQLPVSFRQRLEKANSIRSIRDRKLDELKAAIVPLLPECSRWKSPKRFEGLL 
               
               
                 RQDDLPDGVRDLVNKWAYRDRHLWWFERGCRQGALRYRREIYRLFALEMAKKYPLVIVEDYDLRPIVTDENRIKLP 
               
               
                 SHQRVEGSPSEARHVLLASVSRLGGMVIDGKSKLATQECHLCGYGKEKDERWDASPKIEHTCVGCGENWDQDVNNA 
               
               
                 RVLLARAQVMLESGELLAQPKPKRSARFAKKHKKQNEAVL (SEQ ID NO: 135) 
               
               
                   
               
               
                 &gt;3300017991|Ga0180434_10013735_9 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MFGHASDPSVIYRYGALPPTHNLDAAFEQLRAAHRYRNKLVEIERDRRDKTAAVVSAASPDLAGLESQYAELGERT 
               
               
                 AAAAKQIKATNQRARAQRATPEQKAVLRKLRAECKDVYSRLKEAKALAYKSLEARTALDQADAAALNAAKKARAEC 
               
               
                 ECYWGTYLQVEQGLSGIRKGAPPRFLRWTGNGKLAVQIQGGMSREEAEHGDGRLRIATTERRGKATNVYLRIGTNE 
               
               
                 DRSPIWAVVPVIFHRPIPDDARIKWVYLTARRVACHTRWHVCFVLSRAEGWRKPDLATSGTVAVDLGWRLLDHGLR 
               
               
                 VGYWRGSDGGSEEILLPTRDVARWQKADDLRAIRGERFNGVVDWLAKWLAGRDLPDWLIERTRTLRQWRSAARLAS 
               
               
                 VVIHWRENRFAGDKDGFAAVEAWRKKDKHLYEWEANQRRKAVAWRDDLYRRVAADLSRRYKTAIVEDCNWRDVGRK 
               
               
                 PDVGENNDSGAAARQRTIAAPGRLKQLLVERFAETVKAEAAYTTQRCHACGELAHVETRTSVWVTCQQCGAAWDQD 
               
               
                 DNACRNMLDMVAKGPVT (SEQ ID NO: 141) 
               
               
                   
               
               
                 &gt;3300017992|Ga0180435_10018121_11 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MTKTYVYGLPLGPTVNADLVEEQMRLAHKYRNALIEIERERREKVREVYDERDLALEGLVEEDKVAKSELKRATED 
               
               
                 LKRQRAKTRSRSDTAEQRERVKEVRKAAQEVAKRLSEARKELKLDEDLQERLSRANLTASEKSQAAQQGFSREGLF 
               
               
                 WGTYLQVDNAMEDSRRDLKMWDEHGQPLDPKFLQWRGDGTVAVQLQGDKHPVEKIFSGEDTFLQVDMEPPPEGVVS 
               
               
                 KTRRKKRRGVMKIRIGSTESRGPVWAEFPIIMHRPLPQGVRIKWAVVKRRMISERPRWTVHFSLGLPAEYQHEEFG 
               
               
                 SGRGAVAVDIGWRKRGEDQIRVAYLVDGDEYAAYLRDRQDPLGRGDELLMEPEVVRGFDKVESLQSIRALNQNEMQ 
               
               
                 KSLKGWIKSNKKNLPEWFREDVRYLHSWKSPKRYAGLLRKWGEKRWDGDGEGFQILKDWLSGTYEESLGRRDGGDR 
               
               
                 HLWQWKESQEQKSLRRRKDHYRRVAAKLARKYKVLVIEDFKLTETQKHEPPESEKVEIQAARNQQKEAACYELRMM 
               
               
                 FVQAFLARGGTVVWVDARMTTQRCFECGCLEPWDAIPEVDHVCVECGAKWDQDANAARNIMRLYRNDETLKMIDGS 
               
               
                 VPVEPKMSRRQKGRKKGKKIVQQRKSQEAAQPSV (SEQ ID NO: 142) 
               
               
                   
               
               
                 &gt;3300018065|Ga0180430_10011859_2 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MFGHKADPSLIYRYGAKTPIEHCDVVDAQIRAAHRYYNQLVEIELRRREQATELVRSLSPELDTLTEWREELSETI 
               
               
                 DSVRAEIKAANQRARRKTTTKAQRDQVKALRKQRKAVTELWREAKAAAYDSPDAKAGLAAIDEAANESRRQARAAC 
               
               
                 GVYWGTYLAIEQSIPKTSAPPTFHRWTGDGRVVVQLQGGMSAAEAFACRDNRFRIEPVPEEAWDRGQPKRLQRTRA 
               
               
                 WVRVDSDGRDPVWAVVPITLHRPFPEDCRIKWVYLIRRKVASKDKWSLCLVLSRVEGWQKTDLGASGSVGIDLGWR 
               
               
                 LVAEGLRVAYWAGDDGESGSVVLPMRDVGRWQKARDLQSIRATNFDAIVLRLAGWLAGRELPDWLTERTKTLRQWR 
               
               
                 SQGRLAAVVIQWRAERFDGDAEIFAEVEAWRKQDKHLWEWEHNQRRKAIAWRENVYRQFAAMLSRRYRVVCLEATD 
               
               
                 WRHFMRKVAAEEDGQGGAGAQRYLRIASPGQLSRLLAERFAEVVRVDPKHTTQRCHVCGELAQFDAATSLHTKCRH 
               
               
                 CGAEWDQDYNAARNLLGAASGPVPQETP (SEQ ID NO: 143) 
               
               
                   
               
               
                 &gt;3300018065|Ga0180430_10038979_3 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MFGNKALPSVIYKYGARRPVTNADEVDRQVRDAHRYRNKLVEIERDRRSCVNAKLMQLAPRLLSLETEIERLDNLI 
               
               
                 AEKRSEIKRANATRRRRDVTPEQRAELRQWQADRKALRTELKERKADAFADPRIRTALAKVDAEALAASKAARAAS 
               
               
                 GVYWGTYCQVEQSLSGMRSGAPPRFLRFDGTGKLAVQLQGGLSVAKAFAGEDRRLIIEPVPPKAYLPGEPKALQRT 
               
               
                 RVWLRIGSDGREPIWTIVPITLHRPLPDDASIKWVYLTRRRVATKDRWSVCFVLARESGWQKPGLARNGSVGVNLG 
               
               
                 WRVMDDGVERGLRVARWVGDDGTEGELRLPMPDVERWKKTEDLQAIRDQRFNAAVSLLADWLADPGCLLPDWLVER 
               
               
                 TATLRQWRSAARLAAIAIQWRGERFEGDDTAFATLEAWRKKDKHLYEWQANQLRKAIAWREDLYRNLAATLSRRYH 
               
               
                 TVCLANTDWRDLARRPTAEQAETDAGARRYQRVASPGALGRLLRERFAETVTVDSRHITQRCHACGEVNQFDAAAH 
               
               
                 VRATCRHCGAEWDQDINAARNILRAASGPVACETP (SEQ ID NO: 144) 
               
               
                   
               
               
                 &gt;3300018080|Ga0180433_10006034_17 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MRLANRYYNCLVVIERERRQAVRDALQECDQRHGIDALQDVVDTLKTQRDEAREEIKRARSKTRSRSDTEDQRKRV 
               
               
                 KDLTVQIKEACELVKRARRDIRDDEQAKEQMKAADNIARTKTREARAICGVFWGTYLTIEAAIDAARKAPLWQYGK 
               
               
                 PNDPRFRRFGGRGSVSMQLQGGLAASDVFGDDRRLQIELSPQRKSNSNRSKIRRYGVIRLRVGSSKRDPIWAEWPL 
               
               
                 LMHRQLPDLSTIKWARIVCDRVANEERWSLQLTIDIPEPVKVSDERKGTVAINPGWRLLDYGVRVGYIVDDCNETD 
               
               
                 EIVIDPGVLSGLRKVEDLRSIRDRTQNTMMEEFLPWLRSHKNILPAWLTERTKTIGQWKAAARFAALAHVWSVSRF 
               
               
                 GGDVLGYELLEQWRKQDLHLWQWESFQRRKSIGRRRNQYRRLAKQLAHRYHTLVLDTTNLAEIQRHKSTESEEIEI 
               
               
                 PAARLQQRDAATAELRSYLAEAFHATGGVVVKVNHKRATRRCHVCGHEGPWNQCDEVVHKCESCGSSWDQDENNCR 
               
               
                 NLLERLGDGDKITTKRQAKWDRLGRHNKTARKLDDNDVEIQTN (SEQ ID NO: 145) 
               
               
                   
               
               
                 &gt;3300018080|Ga0180433_10006034_18 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MPTKVYKYGVRPPTKNADIVHEQMRLANRYYNCLVVIERERRQAVRDALQECDQRHGIDALQDVVDTLKTQRDEAR 
               
               
                 EEIKRARSKTRSRSDTEDQRKRVKDLTVQIKEACELVKRARRDIRDDEQAKEQMKAADNIARTKTREARAICGVFW 
               
               
                 GTYLTIEAAIDAARKAPLWQYGKPNDPRFRRFGGRGSVSMQLQGGLAASDVFGDDRRLQIELSPQRKSNSNRSKIR 
               
               
                 RYGVIRLRVGSSKRDPIWAEWPLLMHRQLPDLSTIKWARIVCDRVANEERWSLQLTIDIPEPVKVSDERKGTVAIN 
               
               
                 PGWRLLDYGVRVGYIVDDCNETDEIVIDPGVLSGLRKVEDLRSIRDRTQNTMMEEFLPWLRSHKNILPAWLTERTK 
               
               
                 TIGQWKAAARFAALAHVWSVSRFGGDVLGYELLEQWRKQDLHLWQWESFQRRKSIGRRRNQYRRLAKQLAHRYHTL 
               
               
                 VLDTTNLAEIQRHKSTESEEIEIPAARLQQRDAATAELRSYLAEAFHATGGVVVKVNHKRATRRCHVCGHEGPWNQ 
               
               
                 CDEVVHKCESCGSSWDQDENNCRNLLERLGDGDKITTKRQAKWDRLGRHNKTARKLDDNDVEIQTN (SEQ ID 
               
               
                 NO: 146) 
               
               
                   
               
               
                 &gt;3300018080|Ga0180433_10012134_6 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MWLVHRYSNELVEIERARRKGFHAALAWPEVAEALRVEEEALLARYHVLRDSDSDDRAAEFRKKGKRRRKSSPAVA 
               
               
                 DALAALKAATDAVEDVRAAAVKAIGRDSKKKTAKKKKKKKTATELVKMTPAEVASVTEAINENDAVHGDAAKRKRA 
               
               
                 EFIAQGLYWGNYQVAEASIPRKGPPPKFRRWEGRGHIAVQIQGGMTYAELLGCNHTMARLEIRDDWGSNRRTSRHG 
               
               
                 LLWIRVGSKGKGGREPVWATFPVCWHRHLPEGARIKRIDVTRRIQGVRAVWAVCVTVQTPGASLTKQALVKPTTEA 
               
               
                 LPKAVGLDVGWRSTDDGGIRVAVLYDGDRHYEVALPHWFAEGDRLVSDLQSIRRCRFNAVKDQLLAALREGKHKEQ 
               
               
                 AETFATLASWDSQARLARAVREWEGCPAYLTEWRAKERHLYQWERDAKRYLVEWRKNWYCHWVAWISQRYKNVVIE 
               
               
                 KFDIAKIKKKAEAGEDKEEATGPHSLAAPGELRRILLSTCSREGVQVHLAPAGNTTRKCSVCGKLRRKKKGEGVAL 
               
               
                 MQECPGCGRVMDQDANAARNLYGFASVGVIPETPVAFAVPEAAWYGRFSLTPKKIQSRVARLQAALETSPPDSDGK 
               
               
                 GG (SEQ ID NO: 147) 
               
               
                   
               
               
                 &gt;3300018080|Ga0180433_10012134_6 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MAFHRSTQPTTSRVYRYGLLPPSSGANLVDEQMWLVHRYSNELVEIERARRKGFHAALAVVPEVAEALRVEEEALA 
               
               
                 RYHVLRDSDSDDRAAEFRKKGKRRRKSSPAVADALAALKAATDAVEDVRAAAVKAIGRDSKKKTAKKKKKKKTATE 
               
               
                 LVKMTPAEVASVTEAINENDAVHGDAAKRKRAEFIAQGLYWGNYQVAEASIPRKGPPPKFRRWEGRGHIAVQIQGG 
               
               
                 MTYAELLGCNHTMARLEIRDDWGSNRRTSRHGLLWIRVGSKGKGGREPVWATFPVCWHRHLPEGARIKRIDVTRRI 
               
               
                 QGVRAVWAVCVTVQTPGASLTKQALVKPTTEALPKAVGLDVGWRSTDDGGIRVAVLYDGDRHYEVALPHWFAEGDR 
               
               
                 LVSDLQSIRRCRFNAVKDQLLAALREGKHKEQAETFATLASWDSQARLARAVREWEGCPAYLTEWRAKERHLYQWE 
               
               
                 RDAKRYLVEWRKNWYCHWVAWISQRYKNVVIEKFDIAKIKKKAEAGEDKEEATGPHSLAAPGELRRILLSTCSREG 
               
               
                 VQVHLAPAGNTTRKCSVCGKLRRKKKGEGVALMQECPGCGRVMDQDANAARNLYGFASVGVIPETPVAFAVPEAAW 
               
               
                 YGRFSLTPKKIQSRVARLQAALETSPPDSDGKGG (SEQ ID NO: 148) 
               
               
                   
               
               
                 &gt;3300018080|Ga0180433_10020043_6 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MRVYKYGLPWLLDEEEAPDGAKGGRMAVERQLRAAHVYQNKLIELIRARRLVHRDAVMGYGRVAELHKQVDDINEL 
               
               
                 YQDARDDLKKTRQKERRRAESDRQKAMVAKLRELYKESLAQLYKERRKAFRDSAVKELCKEADESFYEQQRQERTR 
               
               
                 DLTDEERQRGWERPFWGTKQIVEASVKQAHESMPLWDGVRPNDPRFRSWDGSGILGVQNQRPLFSTLNDEQQMDPA 
               
               
                 VQDIFGKDTSLRVDPVDPEAWHNPKRCERKRKSRTVLWMRVGSDENRQPVWACWRMIMHRPLPDGAQIKRASVSKR 
               
               
                 IVGERQKWTVQIYVDDQGCKRAPSCGDGSVTIDLGWRQQQNGVRIATWLGSDGRQGKFKLPQKVIERMFSERGIRK 
               
               
                 TRDENLDRMRPCLEAWIRNQKCLPEWLEKRTKMIGRWRSHARFRALAQYWRGCRFPGDEEGYDMLEAWRYRDHHLW 
               
               
                 NYERGRSMKSRGWRDQLYCQFGAWLARQYGTVVWENFNIAKMAKRPKLGDDYENERARAMRHAVAVATFRDKVENA 
               
               
                 FDTRGGRSRYVSAVNTTRRCHVCGLVDAFDAASSVKRVPPCPGCGASWDQDENACVNMMETYDRGDSSSKPRKTNG 
               
               
                 ARNGKKTNGNAVEGESHWARMKRLKREKDAHK (SEQ ID NO: 149) 
               
               
                   
               
               
                 &gt;3300018080|Ga0180433_10021337_5 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MFGHASDPSVIYRYGALPPTHNLDAAFEQLRAAHRYRNKLVEIERDRRDKTAAVVSAASPDLAGLESQYAELGERT 
               
               
                 AAAAKQIKATNQRARAQRATPEQKAVLRKLRAECKDVYSRLKEAKALAYKSLEARTALDQADAAALNAAKKARAEC 
               
               
                 ECYWGTYLQVEQGLSGIRKGAPPRFLRWTGNGKLAVQIQGGMSREEAEHGDGRLRIATTERRGKATNVYLRIGTNE 
               
               
                 DRSPIWAVVPVIFHRPIPDDARIKWVYLTARRVACHTRWHVCFVLSRAEGWRKPDLATIGTVAVDLGWRLLDHGLR 
               
               
                 VGYWRGSDGGSEEILLPTRDVARWQKADDLRAIRGERFNGVVDWLAKWLAGRDLPDWLIERTRTLRQWRSAARLAS 
               
               
                 VVIHWRENRFAGDKDGFAAVEAWRKKDKHLYEWEANQRRKAVAWRDDLYRRVAADLSRRYKTAIVEDCNWRDVGRK 
               
               
                 PDVGENNDSGAAARQRTIAAPGRLKQLLVERFAETVKAEAAYTTQRCHACGELAHVETRTSVWVTCQQCGAAWDQD 
               
               
                 DNACRNMLDMVAKGPVT (SEQ ID NO: 150) 
               
               
                   
               
               
                 &gt;3300018080|Ga0180433_10021840_7 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MVDDQMRLGNRYYNRLIEIECARRDAIREAMADNDRRHGLSDAIARHARLDEQYNAAKEALKAKRSRARCRVDTAP 
               
               
                 ERAAVRDLRAQRSKAAAELKEARKGHRGDSTMHAAFDAANEEAKLQRRASRAICGVYWGTYLQIEAAVDQAAKETS 
               
               
                 LFFKGKPRDPRFRRWGGSVMVATQLQGGLLALSALACDDSRLQIEMAELGPGPHSRRQLKLRKGTLRLRVGSDGRS 
               
               
                 PIWAEWPLQMHRPLPENGVIKWAKVIRRMVSDRDKWELQLTVEISPEQPCHGEGTVAVDLGWRRKEDGTIRVGYVV 
               
               
                 DDCGLEEEIILDPGVVSGLRKSEDLRSIQDKAQAEMAARVIGWLKAQAELPPWLILATGFVDKWKSARRWRRLASI 
               
               
                 WAEHPDVGSEALSVLSAWAADSLHLWRWEAHQRRKSCLRRKDQYRCLAKRLAAEYRHLVLESKFLAKLQRHVEAED 
               
               
                 EDVEIKAVRLQQRDAAGYELKQCLIYAFRRANGTAVEVDPAMTPQRCNACGFVGRWDAAVEIDHTCEACGATWDQD 
               
               
                 ANACRNLLERERPGDDSGQEAKRQGKWARKKAAKRTARKTVPSGAESFEAGV (SEQ ID NO: 151) 
               
               
                   
               
               
                 &gt;3300018080|Ga0180433_10021840_7 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline lake sediment] 
               
               
                 MIRVYRYGLRRPTTNADLVDDQMRLGNRYYNRLIEIECARRDAIREAMADNDRRHGLSDAIARHARLDEQYNAAKE 
               
               
                 ALKAKRSRARCRVDTAPERAAVRDLRAQRSKAAAELKEARKGHRGDSTMHAAFDAANEEAKLQRRASRAICGVYWG 
               
               
                 TYLQIEAAVDQAAKETSLFFKGKPRDPRFRRWGGSVMVATQLQGGLLALSALACDDSRLQIEMAELGPGPHSRRQL 
               
               
                 KLRKGTLRLRVGSDGRSPIWAEWPLQMHRPLPENGVIKWAKVIRRMVSDRDKWELQLTVEISPEQPCHGEGTVAVD 
               
               
                 LGWRRKEDGTIRVGYVVDDCGLEEEIILDPGVVSGLRKSEDLRSIQDKAQAEMAARVIGWLKAQAELPPWLILATG 
               
               
                 FVDKWKSARRWRRLASIWAEHPDVGSEALSVLSAWAADSLHLWRWEAHQRRKSCLRRKDQYRCLAKRLAAEYRHLV 
               
               
                 LESKFLAKLQRHVEAEDEDVEIKAVRLQQRDAAGYELKQCLIYAFRRANGTAVEVDPAMTPQRCNACGFVGRWDAA 
               
               
                 VEIDHTCEACGATWDQDANACRNLLLERERPGDDSGQEAKRQGKWARKKAAKRTARKTVPSGAESFEAGV (SEQ 
               
               
                 ID NO: 152) 
               
               
                   
               
               
                 &gt;3300001256|JGI12210J13797_10495608_9 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline mat] 
               
               
                 MARKTSKTPTKIYSYGARLDEGDMATARHILWMAQDYYDDRVRIEQARRLAYREARAQVCPWLRDAEVKIDLLELD 
               
               
                 LEKVREELKSKRKSEFRRATGTDLATMAKELLALLKPMRKEARAQRKAASADPGVQAEGQRLDLLAKTLLKSCSKY 
               
               
                 YGAKGLDWRTRGRVDDETRQAFADTASRPWRLGQCKKGFCGRVGGQVLAARGVFLDTDRLFSDWSTVVQIDPLPDH 
               
               
                 TWDTRSGRRKAITAGRISVGSLGPRRPVWLRFTAVIHRRPPRGIIKNAWLFFRERGGRVEAKFQFTLESEEFLRAS 
               
               
                 PEPVHACAIAMTPSRNLSAAVAVGTDGTIQYLSLPEKVWDRFEFAESIRSAADLAFDEVRPSLVEAGLIPHQSRSR 
               
               
                 RRARRAAMGYAREALDAKAVWSTWRDERLGDGVDLWDSPDVVTDWAGRKGHDPLAVLCLVWSKKDGHLDRYEDNVR 
               
               
                 HKARGYRSETYRTWVSALASKYRLFVDPYDAKYLKHAPNPEDDPRIANIERARSRMSLYSLMTTLREKGATEVEAD 
               
               
                 AVEPGAAAHVMRAASVLAKAGEDTTKAVAKIEESRRMVEMARQLDAAE (SEQ ID NO: 153) 
               
               
                   
               
               
                 &gt;3300001256|JGI12210J13797_10495610_14 
               
               
                 [aquatic-non marine saline and alkaline-hypersaline mat] 
               
               
                 MARKTSKTPTKIYSYGARLDEGDMATARHILWMAQDYYDDRVRIEQARRLAYREARAQVCPWLRDAEVKIDLLELD 
               
               
                 LEKVREELKSKRKSEFRRATGTDLATMAKELLALLKPMRKEARAQRKAASADPGVQAEGQRLDLLAKTLLKSCSKY 
               
               
                 YGAKGLDWRTRGRVDDETRQAFADTASRPWRLGQCKKGFCGRVGGQVLAARGVFLDTDRLFSDWSTVVQIDPLPDH 
               
               
                 TWDTRSGRRKAITAGRISVGSLGPRRPVWLRFTAVIHRRPPRGIIKNAWLFFRERGGRVEAKFQFTLESEEFLRAS 
               
               
                 PEPVHACAIAMTPSRNLSAAVAVGTDGTIQYLSLPEKVWDRFEFAESIRSAADLAFDEVRPSLVEAGLIPHQSRSR 
               
               
                 RRARRAAMGYAREALDAKAVWSTWRDERLGDGVDLWDSPDVVTDWAGRKGHDPLAVLCLVWSKKDGHLDRYEDNVR 
               
               
                 HKARGYRSETYRTWVSALASKYRLFVDPYDAKYLKHAPNPEDDPRIANIERARSRMSLYSLMTTLREKGATEVEAD 
               
               
                 AVEPGAAAHVMRAASVLAKAGEDTTKAVAKIEESRRMVEMARQLDAAE (SEQ ID NO: 153) 
               
               
                   
               
               
                 &gt;3300005917|Ga0075115_10002831_4 
               
               
                 [aquatic-non marine saline and alkaline-saline lake] 
               
               
                 MAKVAKGEKMTFVYEYGLRPPSLNADIVDNQLILGNRYRNALVSIERKRRDAIRGWINKPVEKESIAYSEAIESFS 
               
               
                 IAETAMKKQRASTRSRSDTADQRDEVKDLRKKKKDALSVLKAARVKAKKEELFKAEMDDVENQSKQEIKDARSECG 
               
               
                 LYWGTYLVIEAAMAASRKKMPLWDKHFEPANPRYQRWQGTGTVAVQVQKSQQTTADHTMECTGRLIQLDMEKISDE 
               
               
                 ERSKMSKRRQKRCFGTLRMRVGSEGRDPIWAEWPIIMHRPLPSDSTITEVRVIKKKISDHGKWNVHITIKTPDGYY 
               
               
                 KQHNGVDDKCGSGPLALDLGWRLLGTGELRVAYTTDEDGTEEEIRLDHNILTGLKKSDELQGLCDDLQNKMKSTLN 
               
               
                 EWKKTHHLPDWFAEESSHIHAWKKTHKFVRLLHSWSKNRWDGDSEGFDILNDWHFGAYKEDLGRRDGGSRHLWQWR 
               
               
                 EHQRKKSLLRRKDQYRVLAARLSRKYSVLILEDLNLSKLQEHNKSEDDAVEIKEARWQQRAAACYELRECLKQAFL 
               
               
                 SRGGRVLKVKAAMTTQRCFCCGCEKKWDPIPSINHTCDQCGKTWDQDANAAKNIMLLYDKKEFSEQSSGVKKEDAE 
               
               
                 SLSKWGKIGRHKKTSLKLTDNQPEQLN (SEQ ID NO: 154) 
               
               
                   
               
               
                 &gt;3300005918|Ga0075116 10002890_7 
               
               
                 [aquatic-non marine saline and alkaline-saline lake] 
               
               
                 MAKVAKGEKMTFVYEYGLRPPSLNADIVDNQLILGNRYRNALVSIERKRRDAIRGWINKPVEKESIAYSEAIESFS 
               
               
                 IAETAMKKQRASTRSRSDTADQRDEVKDLRKKKKDALSVLKAARVKAKKEELFKAEMDDVENQSKQEIKDARSECG 
               
               
                 LYWGTYLVIEAAMAASRKKMPLWDKHFEPANPRYQRWQGTGTVAVQVQKSQQTTADHTMECTGRLIQLDMEKISDE 
               
               
                 ERSKMSKRRQKRCFGTLRMRVGSEGRDPIWAEWPIIMHRPLPSDSTITEVRVIKKKISDHDKWNVHITIKTPDGYY 
               
               
                 KQHNGVDDKCGSGPLALDLGWRLLGTGELRVAYTTDEDGTEEEIRLDHNILTGLKKSDELQGLCDDLQNKMKSTLN 
               
               
                 EWKKTHHLPDWFAEESSHIHAWKKTHKFVRLLHSWSKNRWDGDSEGFDILNDWHFGAYKEDLGRRDGGSRHLWQWR 
               
               
                 EHQRKKSLLRRKDQYRVLAARLSRKYSVLILEDLNLSKLQEHNKSEDDAVEIKEARWQQRAAACYELRECLKQAFL 
               
               
                 SRGGRVLKVKAAMTTQRCFCCGCEKKWDPIPSINHTCDQCGKTWDQDANAAKNIMLLYDKKEFSEQSSGVKKEDAE 
               
               
                 SLSKWGKIGRHKKTSLKLTDNQPEQLN (SEQ ID NO: 155) 
               
               
                   
               
               
                 &gt;3300011414|Ga0137442_1000121_10 
               
               
                 [aquatic-sediment-groundwater sediment] 
               
               
                 MKRKTSTTPTRIWSFGALEPTENQKALLDQLFFANRYYNTLIEIERKRRNRFREIRSEAVPELSMLEKRYQQLDAD 
               
               
                 YVQMVAALPKPEKGKRKTLTPEVLANKEERKTTSARMKVLRAAFLEDADAKIQTAKADEEAQLAVKAARAATDLYW 
               
               
                 GTYLLIERQVDEARKSKSDPDFRRFDGQGRVGVQLQGGLSTPELLSGEDSRLRLQPRTSTPRVKKPKAQHEVRIRI 
               
               
                 GSLGRDPIWATLPVIVHRPLPEDAEVKWAWVRIVRCGRRRIYSLQLTLESATFDRSQSGVGTVAINFGWRANEDGS 
               
               
                 RRVAYAVDDAGKEQVLSIPASIEKDTTQANSLRSLRDLHFEEAKRSLVAFAALHPKAMPEWYAEEAKFLHQWRNPA 
               
               
                 RLVRLAQRLAEEHPVDSNELLRWRQERLGGARFGRHWRSPGAPKQDLFAPFPEVMSWSTTRGIGALNFYLELWARK 
               
               
                 DKHLWGWEASLRRSVDLRRNDLFRTWAKRMTAYAEVRVEEFDLRKMTAIPAVGEEPRDSSFRSAQRAASPGKLRER 
               
               
                 IAEACGAKVMKGAAFHNTVTCFLCSHVNERSMEHRTVCAGCGEEFDQDANNCRNQLRERPSGAPEAGGARNPQKDP 
               
               
                 VVSDGYDESTVDRDVPSGVVAAE (SEQ ID NO: 156) 
               
               
                   
               
               
                 &gt;3300011431|Ga0137438_1001223_2 
               
               
                 [aquatic-sediment-groundwater sediment] 
               
               
                 MKRKTSTTPTRIWSFGALEPTENQKALLDQLFFANRYYNTLIEIERKRRNRFREIRSEAVPELSMLEKRYQQLDAD 
               
               
                 YVQMVAALPKPEKGKRKTLTPEVLANKEERKTTSARMKVLRAAFLEDADAKIQTAKADEEAQLAVKAARAATDLYW 
               
               
                 GTYLLIERQVDEARKSKSDPDFRRFDGQGRVGVQLQGGLSTPELLSGEDSRLRLQPRTSTPRVKKPKAQHEVRIRI 
               
               
                 GSLGRDPIWATLPVIVHRPLPEDAEVKWAWVRIVRCGRRRIYSLQLTLESATFDRSQSGVGTVAINFGWRANEDGS 
               
               
                 RRVAYAVDDAGKEQVLSIPASIEKDTTQANSLRSLRDLHFEEAKRSLVAFAALHPKAMPEWYAEEAKFLHQWRNPA 
               
               
                 RLVRLAQRLAEEHPVDSNELLRWRQERLGGARFGRHWRSPGAPKQDLFAPFPEVMSWSTTRGIGALNFYLELWARK 
               
               
                 DKHLWGWEASLRRSVDLRRNDLFRTWAKRMTAYAEVRVEEFDLRKMTAIPAVGEEPRDSSFRSAQRAASPGKLRER 
               
               
                 IAEACGAKVMKGAAFHNTVTCFLCSHVNERSMEHRTVCAGCGEEFDQDANNCRNQLRERPSGAPEAGGARNPQKDP 
               
               
                 VVSDGYDESTVDRDVPSGVVAAE (SEQ ID NO: 156) 
               
               
                   
               
               
                 &gt;3300011441|Ga0137452_1000071_9 
               
               
                 [aquatic-sediment-groundwater sediment] 
               
               
                 MKRASREAGQVVVYRYGCPSWADLPESGMVQLRLAHDLRNELVAVEYRYRELIDGIWSSQSAVSVAELALADATAA 
               
               
                 VERAAALMLAQRKIDRSTIPRAGAKQALAEARAARREAKLTVKVAKAIDKEAAGPLLADAKAARYAAITSTRAEYV 
               
               
                 VAGLFWATANDVVQNHDTAAKLVALAWKQGRPARRRTRPWKGTGTITTQVMWQAGKPARTPGVLASATSPWRNVFR 
               
               
                 IEPGRSRGEWPGQPSSGGTVRDDHATVHLRIEKGAEAICLPIVLHRPLPTDGDVAGVQITRRRIAGCYRLSIAITV 
               
               
                 RLPEPTPALGGVPVSVTFGWAAAGDGAVHVARLGAPFGLGPPPPWLVKHLVAIPASATDVDVFAPAIWRLLLARDD 
               
               
                 SIRGHRDDLLDGLREQVITALDEGVEVRLWPDDEDLLRSPVVARWRAPRRFVTLARAWPVEHPMAAMLEAWRLRDR 
               
               
                 HLWEYESHERDQVIARRRDAYRSVAAWICGQASEILLDYPPVAELRQVPDVNEEDEYVARAGRRQVQFAAPGDLRA 
               
               
                 AIEVAARRRGVKVIDVRVPPE (SEQ ID NO: 157) 
               
               
                   
               
               
                 &gt;3300006855|Ga0079044_1002244_2 
               
               
                 [aquatic-thermal springs-hot spring] 
               
               
                 MRVYRYGAKLRGPLDPVAEEQVELANRFWNELVDMHRKYGELLQKAQEEASPALAALRAEMAALAEEKIRLRGLIK 
               
               
                 KSRQKARGNVPADPAIKEQLRAVSQRIKELKPIVKMEKEKAKTASSDERHRLSEQQKLEKKRLRQKYAALGLYWSN 
               
               
                 YNAVLQGFDTAVKRELETQGRLRVRKHAPSGAAVWTVRIQHPTGAREYTWADATRGDPSKPFSIIMPDSEREEFTT 
               
               
                 HDGRTLSRRRLPVARLRVRAERAKTPDGTWVEFGGHHIDVPFYMHRQPPPTARVVMARLVRKRIADCYEYHLCITV 
               
               
                 DEPPAPKRSGTAAGVDLGWRRLPDGAVRVAYVAGEDGAKGALAVPQSTLDRLAHAERLQGIRDSALEGIRSDFVAW 
               
               
                 AKPLGNPALPDFVAAALAGDREHGIPPLASWRSPRRFARLLTGQLVRWAADHPNQAAALPDWPAWNRRIQSWNRQD 
               
               
                 KPLWRTLSFLRVKAIAHRNEQYRIFAKRLAERYAYIVLEDMDIQDMNRKPQAEQAPETSQQKLRHLARAAAPAAVR 
               
               
                 SAIENASWRWGSTFVKVDPANTTRRHAPCGNLVEQNYAESVMVYCPECKVWYDQDENAAVNLLLRIRENPPPAPTN 
               
               
                 PKPANGSRWQRAKAKAR (SEQ ID NO: 158) 
               
               
                   
               
               
                 &gt;3300006855_Ga0079044_1002244_2 
               
               
                 [aquatic-thermal springs-hot spring] 
               
               
                 MGPPAEAPGPRRDTAHSTEEEIASMRVYRYGAKLRGPLDPVAEEQVELANRFWNELVDMHRKYGELLQKAQEEASP 
               
               
                 ALAALRAEMAALAEEKIRLRGLIKKSRQKARGNVPADPAIKEQLRAVSQRIKELKPIVKMEKEKAKTASSDERHRL 
               
               
                 SEQQKLEKKRLRQKYAALGLYWSNYNAVLQGFDTAVKRELETQGRLRVRKHAPSGAAVWTVRIQHPTGAREYTWAD 
               
               
                 ATRGDPSKPFSIIMPDSEREEFTTHDGRTLSRRRLPVARLRVRAERAKTPDGTWVEFGGHHIDVPFYMHRQPPPTA 
               
               
                 RVVMARLVRKRIADCYEYHLCITVDEPPAPKRSGTAAGVDLGWRRLPDGAVRVAYVAGEDGAKGALAVPQSTLDRL 
               
               
                 AHAERLQGIRDSALEGIRSDFVAWAKPLLGNPALPDFVAAALAGDREHGIPPLASWRSPRRFARLTGQLVRWAADH 
               
               
                 PNQAAALPDWPAWNRRIQSWNRQDKPLWRTLSFLRVKAIAHRNEQYRIFAKRLAERYAYIVLEDMDIQDMNRKPQA 
               
               
                 EQAPETSQQKLRHLARAAAPAAVRSAIENASWRWGSTFVKVDPANTTRRHAPCGNLVEQNYAESVMVYCPECKVWY 
               
               
                 DQDENAAVNLLLRIRENPPPAPTNPKPANGSRWQRAKAKAR (SEQ ID NO: 159) 
               
               
                   
               
               
                 &gt;3300009503|Ga0123519_10000481_19 
               
               
                 [aquatic-thermal springs-hot spring] 
               
               
                 MRQLRVAHEVYNTLVQYERERRKAVADATRETDAEVARLEAEVEGLLSRLADLRAAIQAARAGGGDNARLAEAQAE 
               
               
                 ARECRRLLGEAKGALRETKRVARQNPALRERLEAIKAEHHRRQLALYHEVVEVGKRLYWPSWNDTKAAVEQAAKKT 
               
               
                 KNGDLRFRRWTGEGSLYTQVQGKQPVCETATSRWVRIDPVPPEAHDPATPRGERRRLCRTRFYLRIGSTGPREDPV 
               
               
                 FAVFPMVYHRPLPEGAVICGARIVRRKNADREYWQAVVTVDLPDEAAQKSGPRVCALDIGWRDRRPGGSDEPPPLR 
               
               
                 VAAWYDGDRTGEVLVDPSVFERCAKADAIRSTRDRMLDDLRAWLCEARKDLPEHLAEALAGCGLWRAAGKFARLRG 
               
               
                 LLSSGDVPAEVRDRFLAWYHRDRHLWQYEHGMRLNAIRDRDNAYRIAAKRFAQEYDVLIVEATGTPQKERDPKAPA 
               
               
                 AMDLRPLIKEPDPEDAPPRDQQRERKENKAHHQRFIAAAGTFRRYLLEAAAKYGTRVVMVPCEQTTLECWVCGAKY 
               
               
                 EFDRWPLMHECESCGTTWDQDQNAARNLFARGAVAAKGPGPLEVQGKPRLPRWHKRHKAYREGGAG (SEQ ID 
               
               
                 NO: 160) 
               
               
                   
               
               
                 &gt;3300009503|Ga0123519_10000481_22 
               
               
                 [aquatic-thermal springs-hot spring] 
               
               
                 MATRNCRYGLLAPVEGRDEVMRQLRVAHEVYNTLVQYERERRKAVADATRETDAEVARLEAEVEGLLSRLADLRAA 
               
               
                 IQAARAGGGDNARLAEAQAEARECRRLLGEAKGALRETKRVARQNPALRERLEAIKAEHHRRQLALYHEVVEVGKR 
               
               
                 LYWPSWNDTKAAVEQAAKKTKNGDLRFRRWTGEGSLYTQVQGKQPVCETATSRWVRIDPVPPEAHDPATPRGERRR 
               
               
                 LCRTRFYLRIGSTGPREDPVFAVFPMVYHRPLPEGAVICGARIVRRKNADREYWQAVVTVDLPDEAAQKSGPRVCA 
               
               
                 LDIGWRDRRPGGSDEPPPLRVAAWYDGDRTGEVLVDPSVFERCAKADAIRSTRDRMLDDLRAWLCEARKDLPEHLA 
               
               
                 EALAGCGLWRAAGKFARLRGLLSSGDVPAEVRDRFLAWYHRDRHLWQYEHGMRLNAIRDRDNAYRIAAKRFAQEYD 
               
               
                 VLIVEATGTPQKERDPKAPAAMDLRPLIKEPDPEDAPPRDQQRERKENKAHHQRFIAAAGTFRRYLLEAAAKYGTR 
               
               
                 VVMVPCEQTTLECWVCGAKYEFDRWPLMHECESCGTTWDQDQNAARNLFARGAVAAKGPGPLEVQGKPRLPRWHKR 
               
               
                 HKAYREGGAG (SEQ ID NO: 161) 
               
               
                   
               
               
                 &gt;3300006865|Ga0073934_10032691_1 
               
               
                 [aquatic-thermal springs-hot spring sediment] 
               
               
                 MFGHESLPSRIYSYGTMKLGDFPGRDKAEEQMRLAHRYRNRLVEIELARRRAVEEALRRLSPDLVGCELAIEAQER 
               
               
                 ALEVARSSIRRASAEARKKVASPEARDAAKTAIAHLKRERAKRMSLRKALFSSSDWEAEEKRISDEAGAAIRKARA 
               
               
                 ECGLYWGTYLHVEGTVKRTGAPPRFHRWDGSGHLAVQIQHGMTWAEALAGADNRLRVRHAPPTNSKHSQLLHVVSV 
               
               
                 RVGSTEDGFPVWADVPRVVLHRPIPDGARIKWVHLIRRRIGCSQKWHVQFVVSAESWERTDRATSGTVGINVGWRM 
               
               
                 RPDGSLRVAAFCGDDGRRGELCLPSRWLAQWKKTEDIRSIRDRNFDDVRTAIANWVKGTIPEHVRALTGEVMPELP 
               
               
                 PWWRQRAATLASWKSPARLAALTLHWRANRFAGDAVMFPLVEDWRRRDRHLYEYERHLADQLLAEREDLYRVFAAD 
               
               
                 LRRRYKTAIVMELDLRDFHVLPPAEEPTPDGALREHTRDACLSLLHRCLDESMSEVIRSDPRNVTRMCRECGGLND 
               
               
                 WDRKVLHRVCSWCHAEWDQDENAARNLRDRTGGGASDKVA (SEQ ID NO: 162) 
               
               
                   
               
               
                 &gt;3300001340|JGI20133J14441_1002607_2 
               
               
                 [aquatic-thermal springs-hypersaline mat] 
               
               
                 MPFGKKRSDKVAIVYEYGCLPPEGGLPAVAERQLVLADDFWNSLADIDRRHRAKMREILDDGELGKLNAHITSCKA 
               
               
                 RIEELRGQIKGVNQRERRNAGVDANTKAEIARLKAEVKATAARIKEIKPEHIAKQKPLLEENDALRQAAVKRARQW 
               
               
                 FSDRGLYWGTYNAVLRSYETAHKVLLKSGEQMQAHRYTGEGRWVVQIITTAGEKPTTAEDLATGTMVQIDPVDFSD 
               
               
                 WKHISRGERRRRARTKCRIRVGSEGRAPVWLELPCVMHRPLPEGAEIVGADVTRRLVGPARWEYRLHLTLRVPAPV 
               
               
                 PADAAKPAIGVDIGWRALPNGGTRVAYAVGEDGSRKEVVCPDDILAGLAKSSDLRSLRDEKMNRIKAFLRDVIPGL 
               
               
                 DSADLSEQTEHLAMWKSPKRLIRLYRWWKEHRVEGDTEAFGRLHEWYYHDYWHLYQYEDDMRQQVLARRRDMYRIA 
               
               
                 AKEIAERASVVVIEEFDLRKFAQEDQPEDGEDNKIQRARRVAVAPSEFRIALRQACAARGVRVVEKPAQNTTRVHV 
               
               
                 VCGQVVAADYAADVTVRCPRCGVAYDQDANAALNLLGAGRGESTPAAS (SEQ ID NO: 163) 
               
               
                   
               
               
                 &gt;3300009784|Ga0123357_10000018_105 
               
               
                 [arthropoda-digestive system-termite gut] 
               
               
                 MITVVQYGVWHKWMRDVPRDVMDQLWLSHCVREDFVSTTLAYDARLKEIWSSFPVVGEAECRLLEASDALDVLLEE 
               
               
                 QRVVRQSSRSKKVSADLRSRLADARGVVRAARVGRRDAIQVAKDAAMPLIVQAKDAQREARRGLYAKYCSYGVPDR 
               
               
                 DGRVIRLYHATFNDVRVMHEAAEKRLASSRKQGGRGQMRHHRFDGTGTLCVSLLRTAGDPPRTPMVVANSESGAYR 
               
               
                 NVLGVPWVAPVVWEGLSRSQRRADGRVGVRMRVGYGDDLKSPTHVDIPVQAHRFLPAEADITGAKLSIRRRGTKLI 
               
               
                 GSLSITAKDVPDPLPVKDGPSIVLHWGWRDVPTGGAEVARWVSTSPLDIPVDMRGVFTCHDESRMSGAVIAPAVMF 
               
               
                 TKLDHVEALQSELDTAFNEARGVLSEWLRAHPDVVVDDPTSREPVVLTGAVVGAWRSHERLARLAWAWHRECPAGV 
               
               
                 EDMESVLWEWRCGHRHVSNIAANTRARAINARRDVYRNVAAVISGQCGGVGVDDMDLARLASRGASSELPDTVTAP 
               
               
                 GSRRRVYAAPGELRYCIVSACQKDGVTVVTLDTAENSHTCHACGYANPGDDRWLNPMVLCDGCGKVFDQNTNALLN 
               
               
                 LVDKYTATLAV (SEQ ID NO: 164) 
               
               
                   
               
               
                 &gt;3300009784|Ga0123357_10000074_42 
               
               
                 [arthropoda-digestive system-termite gut] 
               
               
                 MVVAPPPVCDLRGNIPWILSWIIDEPAMLGMLLALYAGTLSEMIRVYRYGLLAPTMNGKLVKEQMRAAHRYRNALI 
               
               
                 EIECARRDALRRLLTESGLRELEEETAAANEAVHAAAAAAREARMTVQSKSEPIDARQRMRDAREVSRRALDALRV 
               
               
                 RRREVRENHAVQRAMDEINERAARLRRGARALCGVYWGTYLLVEDADHRARAAALYDGAQPNNPRCSRFVGAGRVG 
               
               
                 VQIQKGFPCETLFGSDARLRVAPVDSGAWHSMRRGERRQLSRTTLSLRIGSEGRDPIWAQWPMLMHRPLPEGSIVK 
               
               
                 RATVSVRRRGPRDEWAVEITVDVADEILAVQRTDSNESAVAIHIGWRAIGNELRVAAWAGSDGRSGELRLPASLLG 
               
               
                 AFAKVEELRSIRDRNLAAARDALSGWLAAAASIPEWLREATVGIMEWRVPSRLAVLAKQWRNVRFVGDEKAYEALE 
               
               
                 AWRYHDYHLWSWEDSQRIHALRARRELYRIFAAQLAREYVSIVIEDFDLRVVAKRHLVEDASIEWRGLRRNRQAAA 
               
               
                 VSELRASLQNASKSRSARIELLDTRSFLQPCHACGSKERFDSVEPLDHSCSGCGAIWDRDSNAALVLLQRWRREHA 
               
               
                 CGGEVAHADVDTKPVPEGRWVRARRHRAEKDAHARFGASDNSEWFGNGNASVISIESPS (SEQ ID NO: 165) 
               
               
                   
               
               
                 &gt;3300009784|Ga0123357_10000076_32 
               
               
                 [arthropoda-digestive system-termite gut] 
               
               
                 MITVIKYGVWHTWSRHIPDSVRDQLWLAHCAREDLVTTTLDYHDALKDIWSSFPEVAAAEQRIRDADDLLATLLDE 
               
               
                 QSKARQASQSKKVPTDLRQRLTQARASVRSAKQERRDAITTAGVIATPLIAQAKDAQYARRKELYTTYCTRGIPDR 
               
               
                 DGRIVRLYHATFNDVRTSHETAEKRISASRANGSPAQMRHHRFDETGTLAVSLLRQAGAPPRTPQVLADTETGKYR 
               
               
                 NVLAMPWFTPDAWAGKTRAQQRVDGRVTLRMRIGYADDLSSPTFVDLPVQAHRFFPPEADITGAKLTIQRRGTTFH 
               
               
                 ATVSITGKGLPDPTPVTSGPAVVLHWGWREVDTDIVEVARWAADAPLHIPDDMGDVFTTDGSGTGGSILTPKTVFT 
               
               
                 RLNHVEKLQSEQGTAFSSAKNALVSWLSTHATPMGDPTSKQPQPLAPALVDAWRSPDRLARLAWLWRDDRPDGADD 
               
               
                 LTADLLAWRGAYRHTATLIANTRAKAISHRNDVYRNVAAVISGQAATVGLDSMDLATIAATSARSELSGDVTQPGA 
               
               
                 RRRTYAAPGTLREYIAAACAKDGVTVSSLDSSHASRTHYECGHTNPRDTKWLNPIVRCDGCGESFDQNTNALHHLQ 
               
               
                 ARQRDLSLTA (SEQ ID NO: 166) 
               
               
                   
               
               
                 &gt;BBPF01004549_6 
               
               
                 [groundwater metagenome] 
               
               
                 MPFGRKAKPCRVFEYGCLPPVSGKDELLKELRLRNNYWNKLVEIDRLIRQRSALILLLPGDIEAAHLDAQIDLMRG 
               
               
                 EIKKGRQRTRSSITDADLKQRIKDSIAELRVLWEQNKKDRKPLIETTRADLAAIETEWRVARKAARADSGLYWCNY 
               
               
                 DDVDTAYDVARKETAKKWAFPKFRRFDGTGKVTVRWQNGLNANNVFDGTGTLLQIAPVHQDAWNHPVRSNRRKASR 
               
               
                 TTVRFRVRSENRSPVWVELPMVMHRPLPAGGEIRSASLVCGYVGGKPTYKLVITVAPPAHTLPEEGMHRGIRPTVG 
               
               
                 INLGWRKKDNDIRIAYWADEEGRHGELTLTSNTLAQFSKLNDLKSIRDKYFNEAISALALYISEGTIPDWLKADTT 
               
               
                 HLNKWRSKPRLLALVGKWRETRFTGDEIIYEALFYWRGRELHLHQWEANLRDQVQRHRRERYRIFAAQLAKDYSQI 
               
               
                 FIENHNLVVTKKKKATEDGTYLTTEVDTLRTIASPGILRGQIENACRREGVIFTKLDAKHITSKCHICGWQEKWNA 
               
               
                 AATITRECPGCKTEWDQDYNAARLLLQRGLDGGYLAVPQTTLEDDPNFCIGS (SEQ ID NO: 167) 
               
               
                   
               
               
                 &gt;BBPG01001333_4 
               
               
                 [groundwater metagenome] 
               
               
                 MPFGRKAKPCRVFEYGCLPPVSGKDELLKELRLRNNYWNKLVEIDRLIRQRSALILLLPGDIEAAHLDAQIDLMRG 
               
               
                 EIKKGRQRTRSSITDADLKQRIKDSIAELRVLWEQNKKDRKPLIETTRADLAAIETEWRVARKAARADSGLYWCNY 
               
               
                 DDVDTAYDVARKETAKKWAFPKFRRFDGTGKVTVRWQNGLNANNVFDGTGTLLQIAPVHQDAWNHPVRSNRRKASR 
               
               
                 TTVRFRVRSENRSPVWVELPMVMHRPLPAGGEIRSASLVCGYVGGKPTYKLVITVAPPAHTLPEEGMHRGIRPTVG 
               
               
                 INLGWRKKDNDIRIAYWADEEGRHGELTLTSNTLAQFSKLNDLKSIRDKYFNEAISALALYISEGTIPDWLKADTT 
               
               
                 HLNKWRSKPRLLALVGKWRETRFTGDEIIYEALFYWRGRELHLHQWEANLRDQVQRHRRERYRIFAAQLAKDYSQI 
               
               
                 FIENHNLVVTKKKKATEDGTYLTTEVDTLRTIASPGILRGQIENACRREGVIFTKLDAKHITSKCHICGWQEKWNA 
               
               
                 AATITRECPGCKTEWDQDYNAARLLLQRGLDGGYLAVPQTTLEDDPNFCIGS (SEQ ID NO: 167) 
               
               
                   
               
               
                 &gt;OGZV01009429_1 
               
               
                 [human gut metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHTLWNKLVEIDRDFREKSTQIITPIKSDYQVLDQEIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSESGLHGFNFDD 
               
               
                 VIHNIYDVARIKAMKQGTLLQFKRYSKNGKIAVRPYSSSPLYGSDIHRVNTIFYIEPVNQELYNSPIRGVRKKASV 
               
               
                 TRCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYAIEAPTINPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDTDDKTIECIVTQRQLNEFDTICGLSSTRQKHLNDCIHVIKAWMANKNLPDWLTDAVAYIDK 
               
               
                 WKSYTHIFDLHSAFLQHKKSGNQEIVSYLEAYIERENHLRTWQSNLQNQVIARRNYEYQNFAAKLANMYDVLVLEK 
               
               
                 LSITNIVKHQKAIIGSQQSTAVDRNRTIVAPYVLKTILINAFRSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYNHDNKGGVSCV (SEQ ID NO: 168) 
               
               
                   
               
               
                 &gt;OKWZ01000119_10 
               
               
                 [human gut metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLSLFDEALDNRHMLWNKLVEIDRDFREKSSKIITPIQSDYQVLDQEIKNLQDAVKA 
               
               
                 IKCKTRSTAKEETRTIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSKSGLHGFNFDD 
               
               
                 VTHNIYEVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGSDIHRVNTIFYIDPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRIGSAVKGKPIFVTLPMVYHRPLPMDGKINAINIKRHYIDQKPIYECFITVTYLIEAPAVNPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDHKAIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFKLYNAFLQHEKSGNQEIISYLEAYIERENHLRIWQSNLQDQAIAKRNYEYQNFAARLANMYDVLVLEK 
               
               
                 LSITDIVKYQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYDNKVGAY (SEQ ID NO: 169) 
               
               
                   
               
               
                 &gt;ODGR01000476_16 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHTLWNKLVEIDRDFREKSSQIITPIQSDYQVLDQEIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSESGLHGFNFDD 
               
               
                 VIHNIYDVARIKAMKQGTLLQFKRYSKNGKIAVRPYSSSPLYGSDIHRVNTIFYIEPVNQELYNSPIRGVRKKASV 
               
               
                 TRCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYFDHKPIYECLITVTYAIEAPTINPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDTDDKTIECIVTQRQLNEFDTICGLSSTRQKHLNDCIHVIKAWMANKNLPDWLTDAVAYIDK 
               
               
                 WKSYTHIFDLHSAFLQHKKSGNQEIVSYLEAYIERENHLRTWQSNLQNQVIARRNYEYQNFAAKLANMYDVLVLEK 
               
               
                 LSITDIVKHQKAMIGSQQSTALDRNRTIVAPYELKTILINAFTNRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYNHNNKVGVSCV (SEQ ID NO: 170) 
               
               
                   
               
               
                 &gt;ODIG01000268_14 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLSLFDEALDNRHMLWNKLVEIDRDFREKSSKIITPIQSDYQVLDQEIKNLQDAVKA 
               
               
                 IKCKTRSTAKEETRTIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSKSGLHGFNFDD 
               
               
                 VTHNIYEVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGSDIHRVNTIFYIDPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRIGSAVKGKPIFVTLPMVYHRPLPMDGKINAINIKRHYIDQKPIYECFITVTYLIEAPAVNPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDHKAIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFKLYNAFLQHEKSGNQEIISYLEAYIERENHLRIWQSNLQDQAIAKRNYEYQNFAARLANMYDVLVLEK 
               
               
                 LSITDIVKYQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYDNKVGAY (SEQ ID NO: 169) 
               
               
                   
               
               
                 &gt;ODIP01002140_2 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHMLWNKLVEIDRNFREKSSQIITPIQSDYQVLDQKIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEQVKQLRSKSGLHGFNFDD 
               
               
                 VIHNIYDVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGADIHKVNTIFYIEPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYVIEAPAVNPSSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDNKTMECIVAQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFELYNAFLQHEKSGNQEIVSYLEAYIERENHLRIWQSNLQDQVIAKRNYEYQNFAAKLANMYDVLVIEK 
               
               
                 LSITDIVKHQKAIIGSQQSTALDRNRTIVAPYVLKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTIWDQDYNACINLLTLYNHDNKVGVSCV (SEQ ID NO: 171) 
               
               
                   
               
               
                 &gt;ODIW01000227_18 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHMLWNKLVEIDRNFREKSSQIITPIQSDYQVLDQKIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEQVKQLRSKSGLHGFNFDD 
               
               
                 VIHNIYDVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGADIHKVNTIFYIEPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYVIEAPAVNPSSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDNKTMECIVAQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFELYNAFLQHEKSGNQEIVSYLEAYIERENHLRIWQSNLQDQVIAKRNYEYQNFAAKLANMYDVLVIEK 
               
               
                 LSITDIVKHQKAIIGSQQSTALDRNRTIVAPYVLKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTIWDQDYNACINLLTLYNHDNKVGVSCV (SEQ ID NO: 171) 
               
               
                   
               
               
                 &gt;ODJA01000260_38 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLSLFDEALDNRHMLWNKLVEIDRDFREKSSKIITPIQSDYQVLDQEIKNLQDAVKA 
               
               
                 IKCKTRSTAKEETRTIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSKSGLHGFNFDD 
               
               
                 VTHNIYEVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGSDIHRVNTIFYIDPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRIGSAVKGKPIFVTLPMVYHRPLPMDGKINAINIKRHYIDQKPIYECFITVTYLIEAPAVNPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDHKAIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFKLYNAFLQHEKSGNQEIISYLEAYIERENHLRIWQSNLQDQAIAKRNYEYQNFAARLANMYDVLVLEK 
               
               
                 LSITDIVKYQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYDNKVGAY (SEQ ID NO: 169) 
               
               
                   
               
               
                 &gt;ODJP01000229_55 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLSLFDEALDNRHMLWNKLVEIDRDFREKSSKIITPIQSDYQVLDQEIKNLQDAVKA 
               
               
                 IKCKTRSTAKEETRTIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSKSGLHGFNFDD 
               
               
                 VTHNIYEVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGSDIHRVNTIFYIDPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRIGSAVKGKPIFVTLPMVYHRPLPMDGKINAINIKRHYIDQKPIYECFITVTYLIEAPAVNPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDHKAIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFKLYNAFLQHEKSGNQEIISYLEAYIERENHLRIWQSNLQDQAIAKRNYEYQNFAARLANMYDVLVLEK 
               
               
                 LSITDIVKYQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYDNKVGAY (SEQ ID NO: 169) 
               
               
                   
               
               
                 &gt;ODKZ01007116_1 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHTLWNKLVEIDRNFREKSSQIITPIQSDYQVLDQEIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSESGLHGFNFDD 
               
               
                 VIHNIYDVARIKAMKQGTLLQFKRYSKNGKIAVRPYSSSPLYGSDIHRVNTIFYIEPVNQELYNSPIRGVRKKASV 
               
               
                 TRCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYAIEAPTINPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDTDDKTIECIVTQRQLNEFDTICGLSSTRQKHLNDCIHVIKAWMANKNLPDWLTDAVAYIDK 
               
               
                 WKSYTHIFDLHSAFLQHKKSGNQEIVSYLEAYIERENHLRTWQSNLQNQVIARRNYEYQNFASKLANMYDVLVLEK 
               
               
                 LSITDIVKHQKAMIGSQQSTALDRNRTIVAPYELKTILINAFTNRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYNHNNKVGVSCV (SEQ ID NO: 172) 
               
               
                   
               
               
                 &gt;ODM001000523_12 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLSLFDEALDNRHMLWNKLVEIDRDFREKSSKIITPIQSDYQVLDQEIKNLQDAVKA 
               
               
                 IKCKTRSTAKEETRTIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSKSGLHGFNFDD 
               
               
                 VTHNIYEVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGSDIHRVNTIFYIDPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRIGSAVKGKPIFVTLPMVYHRPLPMDGKINAINIKRHYIDQKPIYECFITVTYLIEAPAVNPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDHKAIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFKLYNAFLQHEKSGNQEIISYLEAYIERENHLRIWQSNLQDQAIAKRNYEYQNFAARLANMYDVLVLEK 
               
               
                 LSITDIVKYQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYDNKVGAY (SEQ ID NO: 169) 
               
               
                   
               
               
                 &gt;ODTN01000195_35 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLSLFDEALDNRHMLWNKLVEIDRDFREKSSKIITPIQSDYQVLDQEIKNLQDAVKA 
               
               
                 IKCKTRSTAKEETRTIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSKSGLHGFNFDD 
               
               
                 VTHNIYEVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGSDIHRVNTIFYIDPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRIGSAVKGKPIFVTLPMVYHRPLPMDGKINAINIKRHYIDQKPIYECFITVTYLIEAPAVNPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDHKAIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFKLYNAFLQHEKSGNQEIISYLEAYIERENHLRIWQSNLQDQAIAKRNYEYQNFAARLANMYDVLVLEK 
               
               
                 LSITDIVKYQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYDNKVGAY (SEQ ID NO: 169) 
               
               
                   
               
               
                 &gt;ODTP01000194_18 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHTLWNKLVEIDRNFREKSSQIITPIQSDYQVLDQEIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSESGLHGFNFDD 
               
               
                 VIHNIYDVARIKAMKQGTLLQFKRYSKNGKIAVRPYSSSPLYGSDIHRVNTIFYIEPVNQELYNSPIRGVRKKASV 
               
               
                 TRCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYAIEAPTINPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDTDDKTIECIVTQRQLNEFDTICGLSSTRQKHLNDCIHVIKAWMANKNLPDWLTDAVAYIDK 
               
               
                 WKSYTHIFDLHSAFLQHKKSGNQEIVSYLEAYIERENHLRTWQSNLQNQVIARRNYEYQNFASKLANMYDVLVLEK 
               
               
                 LSITDIVKHQKAMIGSQQSTALDRNRTIVAPYELKTILINAFTNRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYNHNNKVGVSCV (SEQ ID NO: 172) 
               
               
                   
               
               
                 &gt;ODWI01002981_3 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLSLFDEALDNRHMLWNKLVEIDRDFREKSSKIITPIQSDYQVLDQEIKNLQDAVKA 
               
               
                 IKCKTRSTAKEETRTIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSKSGLHGFNFDD 
               
               
                 VTHNIYEVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGSDIHRVNTIFYIDPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRIGSAVKGKPIFVTLPMVYHRPLPMDGKINAINIKRHYIDQKPIYECFITVTYLIEAPAVNPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDHKAIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFKLYNAFLQHEKSGNQEIISYLEAYIERENHLRIWQSNLQDQAIAKRNYEYQNFAARLANMYDVLVLEK 
               
               
                 LSITDIVKYQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYDNKVGAY (SEQ ID NO: 169) 
               
               
                   
               
               
                 &gt;ODZZ01005262_2 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLSLFDEALDNRHMLWNKLVEIDRDFREKSSKIITPIQSDYQVLDQEIKNLQDAVKA 
               
               
                 IKCKTRSTAKEETRTIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSKSGLHGFNFDD 
               
               
                 VTHNIYEVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGSDIHRVNTIFYIDPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRIGSAVKGKPIFVTLPMVYHRPLPMDGKINAINIKRHYIDQKPIYECFITVTYLIEAPAVNPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDHKAIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFKLYNAFLQHEKSGNQEIISYLEAYIERENHLRIWQSNLQDQAIAKRNYEYQNFAARLANMYDVLVLEK 
               
               
                 LSITDIVKYQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYDNKVGAY (SEQ ID NO: 169) 
               
               
                   
               
               
                 &gt;OEED01000500_25 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHMLWNKLVEIDRNFREKSSQIITPIQSDYQVLDQKIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEQVKQLRSKSGLHGFNFDD 
               
               
                 VIHNIYDVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGADIHKVNTIFYIEPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYVIEAPAVNPSSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDNKTMECIVAQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFELYNAFLQHEKSGNQEIVSYLEAYIERENHLRIWQSNLQDQVIAKRNYEYQNFAAKLANMYDVLVIEK 
               
               
                 LSITDIVKHQKAIIGSQQSTALDRNRTIVAPYVLKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTIWDQDYNACINLLALYNHDNKVGVSCV (SEQ ID NO: 173) 
               
               
                   
               
               
                 &gt;OEFT01000529_3 
               
               
                 [human metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLSLFDEALDNRHMLWNKLVEIDRDFREKSSKIITPIQSDYQVLDQEIKNLQDAVKA 
               
               
                 IKCKTRSTAKEETRTIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSKSGLHGFNFDD 
               
               
                 VTHNIYEVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGSDIHRVNTIFYIDPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRIGSAVKGKPIFVTLPMVYHRPLPMDGKINAINIKRHYIDQKPIYECFITVTYLIEAPAVNPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDHKAIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFKLYNAFLQHEKSGNQEIISYLEAYIERENHLRIWQSNLQDQAIAKRNYEYQNFAARLANMYDVLVLEK 
               
               
                 LSITDIVKYQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYDNKVGAY (SEQ ID NO: 169) 
               
               
                   
               
               
                 &gt;LAZR01002400_15 
               
               
                 [marine sediment metagenome] 
               
               
                 MNLGRVYYNSLVEAENERRTTMWGGDRPPSPATHVCKKSCSTCDKAESKKRKPRKHECKKFCPVCRAHYKALRKQY 
               
               
                 RSEPPLDVKPFRKKAAEGGLYWGTYLVIEQDFSAAWKETESFSLVKFRSWRQGDMCAVQIQRDKDPDRMFLIKSAP 
               
               
                 DPRKKKQQRYTLRLRVGSKGQAPVWAEPLPFEMHRPLQGTATWVKIARKYVADRVIWSVQFTRRDIPERKDNAERG 
               
               
                 AVAIDVGWRKTDDGMRIAYARGDDGAEYELVLPPKWMKHADQADRIRSARDQNLVELQKQERFWSVILAVCGFSNK 
               
               
                 KLFARLKSTLSVRRVAKPGEHTKWIKKERHLWQYEAGCRNRSVTRRRNDVRVWLRDLRRRYAHAVIKDSCHKKMKE 
               
               
                 NKTSLPKPARRQGHHAAPGEVIEEITRVFGRITGVSVVCAVDTTNHCPACSFVNSYGPERVVTCGGCGVVEDRDRV 
               
               
                 STQNMMNMYAIGNVRNPTTRKSTPRFAKKHKDPEAP (SEQ ID NO: 174) 
               
               
                   
               
               
                 &gt;LAZR01002400_19 
               
               
                 [marine sediment metagenome] 
               
               
                 MTKVYKYGALPGGDTLCAQMNLGRVYYNSLVEAENERRTTMWGGDRPPSPATHVCKKSCSTCDKAESKKRKPRKHE 
               
               
                 CKKFCPVCRAHYKALRKQYRSEPPLDVKPFRKKAAEGGLYWGTYLVIEQDFSAAWKETESFSLVKFRSWRQGDMCA 
               
               
                 VQIQRDKDPDRMFLIKSAPDPRKKKQQRYTLRLRVGSKGQAPVWAEPLPFEMHRPLQGTATWVKIARKYVADRVIW 
               
               
                 SVQFTRRDIPERKDNAERGAVAIDVGWRKTDDGMRIAYARGDDGAEYELVLPPKWMKHADQADRIRSARDQNLVEL 
               
               
                 QKQERFWSVILAVCGFSNKKLFARLKSTLSVRRVAKPGEHTKWIKKERHLWQYEAGCRNRSVTRRRNDVRVWLRDL 
               
               
                 RRRYAHAVIKDSCHKKMKENKTSLPKPARRQGHHAAPGEVIEEITRVFGRITGVSVVCAVDTTNHCPACSFVNSYG 
               
               
                 PERVVTCGGCGVVEDRDRVSTQNMMNMYAIGNVRNPTTRKSTPRFAKKHKDPEAP (SEQ ID NO: 175) 
               
               
                   
               
               
                 &gt;FLSK01003024_2 
               
               
                 [metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLSLFDEALDNRHMLWNKLVEIDRDFREKSSKIITPIQSDYQVLDQEIKNLQDAVKA 
               
               
                 IKCKTRSTAKEETRTIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSKSGLHGFNFDD 
               
               
                 VTHNIYEVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGSDIHRVNTIFYIDPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRIGSAVKGKPIFVTLPMVYHRPLPMDGKINAINIKRHYIDQKPIYECFITVTYLIEAPAVNPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDHKAIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFKLYNAFLQHEKSGNQEIISYLEAYIERENHLRIWQSNLQDQAIAKRNYEYQNFAARLANMYDVLVLEK 
               
               
                 LSITDIVKYQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYDNKVGAY (SEQ ID NO: 169) 
               
               
                   
               
               
                 &gt;OFLM01000072_9 
               
               
                 [metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHTLWNQLVEIDRNFREKSSQIITPIQSDYQVLDQEIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRIIKDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEQVKQLRSKSGLHGFNFDD 
               
               
                 VIHNIYDVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGADIHKVNTIFYIEPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYVIEAPAVNPSSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDNKTMECIVAQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFELYNAFLQHEKSGNQEIVSYLEAYIERENHLRIWQSNLQDQVIAKRNYEYQNFAAKLANMYDVLVIEK 
               
               
                 LSITDIVKHQKAIIGSQQSTALDRNRTIVAPYVLKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTIWDQDYNACINLLALYNHDNKVGVSCV (SEQ ID NO: 176) 
               
               
                   
               
               
                 &gt;OFL001000090_50 
               
               
                 [metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHTLWNQLVEIDRNFREKSSQIITPIQSDYQVLDQEIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRIIKDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEQVKQLRSKSGLHGFNFDD 
               
               
                 VIHNIYDVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGADIHKVNTIFYIEPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYVIEAPAVNPSSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDNKTMECIVAQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFELYNAFLQHEKSGNQEIVSYLEAYIERENHLRIWQSNLQDQVIAKRNYEYQNFAAKLANMYDVLVIEK 
               
               
                 LSITDIVKHQKAIIGSQQSTALDRNRTIVAPYVLKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTIWDQDYNACINLLALYNHDNKVGVSCV (SEQ ID NO: 176) 
               
               
                   
               
               
                 &gt;OFLU01000140_22 
               
               
                 [metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHTLWNKLVEIDRDFREKSSQIITPIQSDYQVLDQEIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSESGLHGFNFDD 
               
               
                 VIHNIYDVARIKAMKQGTLLQFKRYSKNGKIAVRPYSSSPLYGSDIHRANTIFYIEPVNQELYNSSIRGVRKKASV 
               
               
                 TRCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYAIEAPTINPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDTDDKTIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWMANKNLPDWLTDAVTYIDK 
               
               
                 WKSYKHIFELHDAFLQHKKSGNQEIVSYLEAYIERENHLRTWQSNLQDQVIARRNYEYQNFAAKLANMYDVLVLEK 
               
               
                 LSITDIVKHQKAIIGSQQSTALDRNRTIVAPYELKKILINAFTNRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYNHDNKVGVSYV (SEQ ID NO: 177) 
               
               
                   
               
               
                 &gt;OFLV01000230_3 
               
               
                 [metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHTLWNKLVEIDRDFREKSSQIITPIQSDYQVLDQEIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSESGLHGFNFDD 
               
               
                 VIHNIYDVARIKAMKQGTLLQFKRYSKNGKIAVRPYSSSPLYGSDIHRANTIFYIEPVNQELYNSSIRGVRKKASV 
               
               
                 TRCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYAIEAPTINPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDTDDKTIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWMANKNLPDWLTDAVTYIDK 
               
               
                 WKSYKHIFELHDAFLQHKKSGNQEIVSYLEAYIERENHLRTWQSNLQDQVIARRNYEYQNFAAKLANMYDVLVLEK 
               
               
                 LSITDIVKHQKAIIGSQQSTALDRNRTIVAPYELKKILINAFTNRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYNHDNKVGVSYV (SEQ ID NO: 177) 
               
               
                   
               
               
                 &gt;OGCY01000078_30 
               
               
                 [metagenome] 
               
               
                 MNKVSITKVFKYRCFEPFEGLELFNEALDNRHTLWNKLVEIDRDFREKSSQIITPIQSEYQILDQEIKNLQDSIKA 
               
               
                 IKRETRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSESGLHGFNFDD 
               
               
                 VIHNIYDVARIKAMKQGTLLQFKRYSKNGKIAVRPYSSSPLYGSDIHRVNTIFYIEPVNQELYNSSIRGVRKKASV 
               
               
                 TRCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYAIEAPTINPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDTDDKTIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWMANKNLPDWLTDAVAYIDK 
               
               
                 WKSYKHIFDLYDAFLQHKKSGNQEIVSYLEAYIERENHLRTWQSNLQDQVIARRNYEYQNFAAKLANMYDVLVLEK 
               
               
                 LSITDIVKHQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTNRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYNHDNKVGVSYV (SEQ ID NO: 178) 
               
               
                   
               
               
                 &gt;OGJ001000473_2 
               
               
                 [metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLSLFDEALDNRHMLWNKLVEIDRDFREKSSKIITPIQSDYQVLDQEIKNLQDAVKA 
               
               
                 IKCKTRSTAKEETRTIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSKSGLHGFNFDD 
               
               
                 VTHNIYEVARVKAMKQGTLLRFKRYSKNGKIAVRPYSNSPLYGSDIHRVNTIFYIDPVNQELYNSPIRGVRKKASV 
               
               
                 TQCHIRIGSAVKGKPIFVTLPMVYHRPLPMDGKINAINIKRHYIDQKPIYECFITVTYLIEAPAVNPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDKDHKAIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWIANKNLPDWLIDAVAYIDK 
               
               
                 WKSYTHIFKLYNAFLQHEKSGNQEIISYLEAYIERENHLRIWQSNLQDQAIAKRNYEYQNFAARLANMYDVLVLEK 
               
               
                 LSITDIVKYQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTSRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYDNKVGAY (SEQ ID NO: 169) 
               
               
                   
               
               
                 &gt;OGJT01000109_37 
               
               
                 [metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHTLWNKLVEIDRDFREKSTQIITPIQSDYQVLDQEIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKETVKQLRSESGLHGFNFDD 
               
               
                 VIHNIYDVARIKAMKQGTLLQFKRYSKNGKIAVRPYSSSPLYGSDIHRINTIFYIEPVNQELYNSSIRGIRKKASV 
               
               
                 TRCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYAIEAPTINPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDTDDKTIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWMANKNLPDWLTDAVAYIDK 
               
               
                 WKSYKHIFDLYDAFLQHKKSGNQEIVSYLESYIERENHLRTWQSNLQVQVIARRNYEYQNFAAKLANMYDVLVLEK 
               
               
                 LSITDIVKHQKAIIGSQQSTALDRNRTIVAPYELKKILINAFTNRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYNHDNKVGVSNV (SEQ ID NO: 179) 
               
               
                   
               
               
                 &gt;OGJZ01005194_5 
               
               
                 [metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHTLWNKLVEIDRDFREKSSQIITPIQSDYQVLDQEIKSLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNHERKEKVKQLRSESGLHGFNFDD 
               
               
                 VIHNIYDVARIKAMKQGTLLRFKRYSKNGKIAVRPYSSSPLYGSDIHRVNTIFYIEPVNQELYNSSIRGVRKKASV 
               
               
                 TRCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYAIKSPAVNPDSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDTDNKTMECIVAQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWMANKNLPDWLTDAVAYIDK 
               
               
                 WKSYKHIFDLYDAFLQHKKSGNQEIVSYLEAYIERENHLRIWQSNLQDQVIARRNYGYQNFAAKLANMYDVLVLEK 
               
               
                 LSITDIVKHQKAIIGSQQSTALDRNRTIVAPYELKTILINAFTNRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYNHDNKVGVSYV (SEQ ID NO: 180) 
               
               
                   
               
               
                 &gt;OGKO01001669_8 
               
               
                 [metagenome] 
               
               
                 MNKVSITKVFKYRCFEPVEGLALFDEALDNRHTLWNKLVEIDRDFREKSSQIITPIQSDYQVLDQEIKNLQDSIKA 
               
               
                 IKRKTRSTAKEETRNIQDTIKELKVKRKEAYQEFKRLKHEAIEREKPLLDCLNNERKEKVKQLRSESGLHGFNFDD 
               
               
                 VIHNIYDVARIKAMKQGTLLQFKRYSKNGKIAVRPYSSSPLYGSDIHRVNTIFYIESVNQELYNSPIRGVRKKASV 
               
               
                 TRCHIRVGSADKGKPIFVTLPMVYHRPLPMDGKINAINVKRHYIDHKPIYECLITVTYAIEAPTINPNSCVAVDLG 
               
               
                 WRMTKDGLRAAYATDTDDKTIECIVTQRQLNEFDTIRGLSSTRQKHFNDCIHVIKAWMANKNLPDWLTDAVAYIDK 
               
               
                 WKSYKHIFDLYDAFLQHKKSGNQEIVSYLEAYIERENHLRTWQSNLQDQVIARRNYEYQNFAAKLANMYDVLVLEK 
               
               
                 LSITDIVKHQKAIIGSQQSTALDRNRTIVAPYELKKILINAFTNRGKQFVEVNASYSTKVCHHCGALEEVHQSSIM 
               
               
                 HTCTQCHTVWDQDYNACINLLALYNHDNKVGVSYV (SEQ ID NO: 181) 
               
               
                   
               
               
                 &gt;OFCI01000292_37 
               
               
                 [metagenomes unclassified sequences.] 
               
               
                 MWYAHRYGNVLVEIERARRAAVRLAYGPLATFEHAAKEAGTVVRDAREAIKRARAEHRARVETDAMKLALSSAREA 
               
               
                 EREAKRALFEARRQLRESGAVDAALADIEARAGELRRGARALSGVHWGTYSLIEAAHDASRKMPLYDGVEPNDPRF 
               
               
                 ARWEHEGQVGIQVHQKGSTGTGMVAEELHAGIGGEWLRVERVHDTRQGRRAGTRARLTMRIGTSDVDGTPIVAAWP 
               
               
                 MVMHRAVPPGAIVRRATVSLRRRGPREEWSVELTIQVPSTIAPEERQGHVAINVGWRSMGDTIRVASWVGSDGQKG 
               
               
                 ELHLSKRTIEGLRKPEGLRSTRDKNFNDARNALLLALAGLNVPEWYTLRAKALSQWRSPQRLAALATEWKTKRFAG 
               
               
                 DESAYLALETWRYHDHHLWAWEASQSVGSHRHRREVYRVFGSQLAKRYRTLVLADFDKRVVAIRPAVGDANDKTQN 
               
               
                 ETARSNRQLASTSELEREAANAFTSRGGTAEYLSAVDITHTCADCGALSTFDAAERIHAACSSCGVVFDQDENAAR 
               
               
                 VLCERWRDGEKVGVARVAEPQEKVGSKWQRAKARKEERQAARKAVASAAE (SEQ ID NO: 182) 
               
               
                   
               
               
                 &gt;3300006048|Ga0075363_100000001_25 
               
               
                 [plants-endosphere-populus endosphere] 
               
               
                 MAFGNKSKPTRKYNYGCRGFLSGPREINPDGTKALRQRFDGHDLAVTQMKLAHQFQNKLVEIERARREAIDPILVR 
               
               
                 HFPALTTLHNAAQEQQERLQELRDELSQSNSQNRQLMSDPELVEQINAQKRVVSQAWEFYSDQRDAAFADPKVKAD 
               
               
                 LKDNDKSFEQRKADARNAAVEGGLYWATSLQVVGRVKRTGPPPKFKSWRGEEVISVQFQRKPDKTSPKEPVLDSKG 
               
               
                 NPKIHPRSKKPTFAHVGGSSLRTCDVFTPNTNCWIERTYQPPLTAPHPKYVVIHFRVSSDEKGKPVMASIPAVMSR 
               
               
                 PLPEDGEVKWVHLSRRKIGTHYRWDVQFDIARDAWTYHPAGQDRAQEGTVAVALGWRLIDGEIRVTEWVGDDGVTG 
               
               
                 TVRIPKELVEGWSYLDTLQSIRDTLFEAERAELVDWFVNYPNPLPEEWTERAQTLIQWRSADRFMWLIWWWKDHRI 
               
               
                 PGDEEIFQRMWGRIQLNPTTGRNQYTGGRLQSKHLCDWRAHKRDKIKNWRKDFFRKVAIDLSYQYKDVVIAEIDWN 
               
               
                 KLAENPEVENGNDIVNKRYRALSSCAQLRDEITRYMNEVTESARNIVTTCCQCGESCDHPKSGRWIRCESCGGEKR 
               
               
                 DRAVNAATNLLNRALGASGAKVPARV (SEQ ID NO: 183) 
               
               
                   
               
               
                 &gt;3300006048|Ga0075363_100000001_20 
               
               
                 [plants-endosphere-populus endosphere] 
               
               
                 MVAAKISHLLEFPSMAFGNKSKPTRKYNYGCRGFLSGPREINPDGTKALRQRFDGHDLAVTQMKLAHQFQNKLVEI 
               
               
                 ERARREAIDPILVRHFPALTTLHNAAQEQQERLQELRDELSQSNSQNRQLMSDPELVEQINAQKRVVSQAWEFYSD 
               
               
                 QRDAAFADPKVKADLKDNDKSFEQRKADARNAAVEGGLYWATSLQVVGRVKRTGPPPKFKSWRGEEVISVQFQRKP 
               
               
                 DKTSPKEPVLDSKGNPKIHPRSKKPTFAHVGGSSLRTCDVFTPNTNCWIERTYQPPLTAPHPKYVVIHFRVSSDEK 
               
               
                 GKPVMASIPAVMSRPLPEDGEVKWVHLSRRKIGTHYRWDVQFDIARDAWTYHPAGQDRAQEGTVAVALGWRLIDGE 
               
               
                 IRVTEWVGDDGVTGTVRIPKELVEGWSYLDTLQSIRDTLFEAERAELVDWFVNYPNPLPEEWTERAQTLIQWRSAD 
               
               
                 RFMWLIWWWKDHRIPGDEEIFQRMWGRIQLNPTTGRNQYTGGRLQSKHLCDWRAHKRDKIKNWRKDFFRKVAIDLS 
               
               
                 YQYKDVVIAEIDWNKLAENPEVENGNDIVNKRYRALSSCAQLRDEITRYMNEVTESARNIVTTCCQCGESCDHPKS 
               
               
                 GRWIRCESCGGEKRDRAVNAATNLLNRALGASGAKVPARV (SEQ ID NO: 184) 
               
               
                   
               
               
                 &gt;3300006048|Ga0075363_100000020_49 
               
               
                 [plants-endosphere-populus endosphere] 
               
               
                 MIVYKYGALKPKVIGGTFEDLLQYQRHSNAFYNALIEIERWRIAARDIVELAQSAPLSDEQKTEHRLAYNAACRAA 
               
               
                 GAATPIGWGQKQAVTEMVAAAMKTRRSDEFKARQRASKKGYDFLKRVMTCARPRHRRFDGEGILAATVQGATGLKA 
               
               
                 SAVLTKPGPVQISGDGKHRTVTLRLREGLSLEVPIVYHRPLPERAEKEGVPYDVRVIFARLVIDRIGDRWTYSVHL 
               
               
                 TIDAAPRVHVAQGGLGRCAVNFGWRRVPGGIRVAYAVDDDGNETSCVFPDALLGRQKHAESLRSLADEIAAAYLGD 
               
               
                 AARRTKARCSALADPDAIHRELGREWFTMEQAAKRDGTDAEHWARRDRHLYQWERDEYASVLRARREIYRLWARKL 
               
               
                 AASYDSVIIEAFDMRSVVKRTPSEDDIPAARHYRFLVGPHCLRLEIQSVFGARCEVLKPAKRTLTCHACGALCKWD 
               
               
                 KARELRHDCESCGAAWDQDANNAKNQLLDAAE (SEQ ID NO: 185) 
               
               
                   
               
               
                 &gt;3300006178|Ga0075367_10000108_6 
               
               
                 [plants-endosphere-populus endosphere] 
               
               
                 MAFGNKSKPTRKYNYGCRGFLSGPREINPDGTKALRQRFDGHDLAVTQMKLAHQFQNKLVEIERARREAIDPILVR 
               
               
                 HFPALTTLHNAAQEQQERLQELRDELSQSNSQNRQLMSDPELVEQINAQKRVVSQAWEFYSDQRDAAFADPKVKAD 
               
               
                 LKDNDKSFEQRKADARNAAVEGGLYWATSLQVVGRVKRTGPPPKFKSWRGEEVISVQFQRKPDKTSPKEPVLDSKG 
               
               
                 NPKIHPRSKKPTFAHVGGSSLRTCDVFTPNTNCWIERTYQPPLTAPHPKYVVIHFRVSSDEKGKPVMASIPAVMSR 
               
               
                 PLPEDGEVKWVHLSRRKIGTHYRWDVQFDIARDAWTYHPAGQDRAQEGTVAVALGWRLIDGEIRVTEWVGDDGVTG 
               
               
                 TVRIPKELVEGWSYLDTLQSIRDTLFEAERAELVDWFVNYPNPLPEEWTERAQTLIQWRSADRFMWLIWWWKDHRI 
               
               
                 PGDEEIFQRMWGRIQLNPTTGRNQYTGGRLQSKHLCDWRAHKRDKIKNWRKDFFRKVAIDLSYQYKDVVIAEIDWN 
               
               
                 KLAENPEVENGNDIVNKRYRALSSCAQLRDEITRYMNEVTESARNIVTTCCQCGESCDHPKSGRWIRCESCGGEKR 
               
               
                 DRAVNAATNLLNRALGASGAKVPARV (SEQ ID NO: 183) 
               
               
                   
               
               
                 &gt;3300006178|Ga0075367_10000108_6 
               
               
                 [plants-endosphere-populus endosphere] 
               
               
                 MVAAKISHLLEFPSMAFGNKSKPTRKYNYGCRGFLSGPREINPDGTKALRQRFDGHDLAVTQMKLAHQFQNKLVEI 
               
               
                 ERARREAIDPILVRHFPALTTLHNAAQEQQERLQELRDELSQSNSQNRQLMSDPELVEQINAQKRVVSQAWEFYSD 
               
               
                 QRDAAFADPKVKADLKDNDKSFEQRKADARNAAVEGGLYWATSLQVVGRVKRTGPPPKFKSWRGEEVISVQFQRKP 
               
               
                 DKTSPKEPVLDSKGNPKIHPRSKKPTFAHVGGSSLRTCDVFTPNTNCWIERTYQPPLTAPHPKYVVIHFRVSSDEK 
               
               
                 GKPVMASIPAVMSRPLPEDGEVKWVHLSRRKIGTHYRWDVQFDIARDAWTYHPAGQDRAQEGTVAVALGWRLIDGE 
               
               
                 IRVTEWVGDDGVTGTVRIPKELVEGWSYLDTLQSIRDTLFEAERAELVDWFVNYPNPLPEEWTERAQTLIQWRSAD 
               
               
                 RFMWLIWWWKDHRIPGDEEIFQRMWGRIQLNPTTGRNQYTGGRLQSKHLCDWRAHKRDKIKNWRKDFFRKVAIDLS 
               
               
                 YQYKDVVIAEIDWNKLAENPEVENGNDIVNKRYRALSSCAQLRDEITRYMNEVTESARNIVTTCCQCGESCDHPKS 
               
               
                 GRWIRCESCGGEKRDRAVNAATNLLNRALGASGAKVPARV (SEQ ID NO: 184) 
               
               
                   
               
               
                 &gt;3300006195|Ga0075366 10000160_13 
               
               
                 [plants-endosphere-populus endosphere] 
               
               
                 MAFGNKSKPTRKYNYGCRGFLSGPREINPDGTKALRQRFDGHDLAVTQMKLAHQFQNKLVEIERARREAIDPILVR 
               
               
                 HFPALTTLHNAAQEQQERLQELRDELSQSNSQNRQLMSDPELVEQINAQKRVVSQAWEFYSDQRDAAFADPKVKAD 
               
               
                 LKDNDKSFEQRKADARNAAVEGGLYWATSLQVVGRVKRTGPPPKFKSWRGEEVISVQFQRKPDKTSPKEPVLDSKG 
               
               
                 NPKIHPRSKKPTFAHVGGSSLRTCDVFTPNTNCWIERTYQPPLTAPHPKYVVIHFRVSSDEKGKPVMASIPAVMSR 
               
               
                 PLPEDGEVKWVHLSRRKIGTHYRWDVQFDIARDAWTYHPAGQDRAQEGTVAVALGWRLIDGEIRVTEWVGDDGVTG 
               
               
                 TVRIPKELVEGWSYLDTLQSIRDTLFEAERAELVDWFVNYPNPLPEEWTERAQTLIQWRSADRFMWLIWWWKDHRI 
               
               
                 PGDEEIFQRMWGRIQLNPTTGRNQYTGGRLQSKHLCDWRAHKRDKIKNWRKDFFRKVAIDLSYQYKDVVIAEIDWN 
               
               
                 KLAENPEVENGNDIVNKRYRALSSCAQLRDEITRYMNEVTESARNIVTTCCQCGESCDHPKSGRWIRCESCGGEKR 
               
               
                 DRAVNAATNLLNRALGASGAKVPARV (SEQ ID NO: 183) 
               
               
                   
               
               
                 &gt;3300009500_Ga0116229_10010095_9 
               
               
                 [plants-peat moss-host associated] 
               
               
                 MTTLVYQFHLDPPVSGERAARQQMLAAHRYANDLIAIERGRRDALRAVHDTPAVREAEVLLKAATRSTRKAAVKAL 
               
               
                 WAARREAERIASEVDETLPEVAAAKAALDALPKDAPARVRSVARQTLRAARAEAGDALARIQIFDEALRRGARALT 
               
               
                 TAHWGTYLSIEASADQARKAPLYADDALTPASPRFRFGARRGYLDESDARSVWWCARSQVGMHVQGRVCRTSGVFA 
               
               
                 GRDAWVRLEDAEPISHDHNTRRAILALRLDVDTWVRWPIRMHREIPDAARWSWVRVSCRPQQGARGKELWSVEITV 
               
               
                 DDTAPRPRELAADTLRGAVAVELLWSPLDDGTMRVARWLDSEGKRGEIVLPRELVRGLGEIPSGIRSVRDQLLNDL 
               
               
                 RPKLTRALRECTETMPTWLREAGATLHLWKSPSRFVDLARRWRASKCDAARAAYELLDAWELRDTHLDDYENGTRA 
               
               
                 RSLRRRREVYRVLAARWAQSYATVLVPDRDLSREARWGEESERRFLASPQELRDCLRKAFGDGAVDVPWRGPHGVV 
               
               
                 DDGDEDADVPEWLEKAIEQWRDEEKSGSARKGGKEKKNGEVAMSAWARRQAAARDRDLGKETARKAANNDAE 
               
               
                 (SEQ ID NO: 186) 
               
               
                   
               
               
                 &gt;3300009701|Ga0116228_10018148_5 
               
               
                 [plants-peat moss-host associated] 
               
               
                 MKIVYRYGLRAPIGHTPTNPTSKEVCKCPVCEQLFLAHSYANTLTEIERGRRAAVRALHAQVGDTGALELAVTEAN 
               
               
                 QACEKAASNIKRLRAQAFSVLAQRGHTEGAAKRGTRVTPPEMARELADARKRKQEATTRLVEHRRKIREDPAMIVG 
               
               
                 EHEITERAKELQRSARKYAGVYWGTYLLVERAHGASIASLPLYDGAGPNDPRFDRYRGEGSLAVQIQQQTGDPAFT 
               
               
                 VEQLSGSDSRVQIQKEAGRLHTRLKRDEEGRVVREGPLVEMRRGNCIVARPQAVRETYSMVGDTMLRLRIGSENRA 
               
               
                 PVWAEWPLKLSKPLPKGAIVSWVTVTKRMTGPREEWSVQFTLDTVDEVVQRDVDEEDARVVAVNFGWRLMGEELRV 
               
               
                 AYWRSETGRNGDLRLPASMLAIRAEAEEVQSRRDKEFDETRARLCKWLASTEVPTWLRDATKALAQWRSQARLVHL 
               
               
                 AKGWRVQRFAGDQEAFETLEAWRYHEHHLWQWESSVRATAVRSRDDLYKRWAKILADNFDVLVIAGDFDVRKVAER 
               
               
                 PEVDEEIQGPAAAATSRQFAAPGRLREILCHAFTKAGSKIAKERGADITRTCQVCGLVEEFDAARSVIRATPCSGC 
               
               
                 NATWDQDDNACIELLARYDRTCEKSKNTSSDDGARAEPKNETKKAAGSHWDRARQKKVEKLKKVEAARQALENTG 
               
               
                 (SEQ ID NO: 187) 
               
               
                   
               
               
                 &gt;3300005577|Ga0068857_100000008_197 
               
               
                 [plants-rhizoplane-corn rhizosphere] 
               
               
                 MEPVKKSNARKTSTSETKVYSYGAFLPKESEQIKLINDQLYFAHKYRNKLVEIERKRRNRFRNLRKLMSPELRQLE 
               
               
                 NDLLLTEEKIIELRKSFGGRAENSLDPKFPKKNRQLTPQAVEIKDLKLKKKDLSAKIKSIHTQLNLDYFKEADSKF 
               
               
                 SLLKKERLEQKAKELNKDSLGPNDVNRHNVVNNLYKEMIDGGNRFWAIKAKISKSAEASNKRARSNCKCSSGTYVS 
               
               
                 IEEAAKQSFSNSKFEPKFKSFDGSGKIGMQLTQNKGLSIKDALSGSSPVLKIDLHPEVYLRQNKKKNKVLATARIK 
               
               
                 LFGTEKTGKFVDIPFIMHRQMPEDATIKWVFLVVSKIGYRSIYNIQFTIESNSFTQPSAIRPDDVAINLGWKVNDQ 
               
               
                 TDDITVATSFDGKNYNELILPSKMRANIVYKETLISHADKHFDSVKKDVSKWLKNSNLDECITKYFTNLPQWRSHK 
               
               
                 KLLFVSKELAKVFLPDNTWYDLWKKWKTHCKENKPWKNCSDKDDLFTTLDNTIQWCKDNSIDDPNVQMAFYLKTWA 
               
               
                 EKEIHLINWARGIESKLRKHRKEIYRCFAKKLSSTYGKVIVENWDKSKTAETPDVENDNRTKQEENANAVRQFVGV 
               
               
                 SVLTDALKQKFGKDFCEENAKNISKEHFKCGGELINQKELSDVHCKKCNKSVNVNYNAAAHLFDRHGERSGAVKLP 
               
               
                 GTARKTRKSPELLA (SEQ ID NO: 188) 
               
               
                   
               
               
                 &gt;3300005338|Ga0068868_100030384 5 
               
               
                 [plants-rhizoplane-miscanthus rhizosphere] 
               
               
                 MRIYAYGARPPVENAELVFEQLRLAHAYQCALVAIERRRRVVVDRLYQSACPAEWNAYEAATARVQEIIPRMRMTR 
               
               
                 TRPGDMLPPDMEMQVEEREIVKQIKADLAAAREAEQVARQAWYAAKKMATPRLRARLRMCDRGAYARAKRAYNLAS 
               
               
                 AVGLAWGTRLKIAESVERAGKAAAKHGTLPHFPRFDGGGTIAVQIQGGLDAEAVFGGVDTRFRLNVVDAATWNALQ 
               
               
                 GKSATQSVKKSGRVVDLPQPIEGSRRSTLRRGPIARLRIGSEGRQPIWAAWPVTLRRGLPLKALIKWVQIHARKIG 
               
               
                 SRTEWQLLVTVDDAKPAVHAEGPILAVNLGWRNLEDGGLRVGYAVGSDGREEEVRVPPRYTSGVAHVDSIRSIRDK 
               
               
                 LFEAVKEFLSDWSDESPRPPDWLVDATRHIDQWRSPARLVTLLREWERKRFVGDRKTWERLSAWKTKNAHLRFWEC 
               
               
                 DERRKLLRMRLDFYRCLAARWASQYARVVVTDMDLRDFAKLPEPEEAADTEGQTQRRSRVLAAPSELRGAIKNACS 
               
               
                 TRGTGYEEKKAAWKTQTCNACGVVFAFAAKQDLLHICECGARWDQDANHCRNLLASGPVLHGAMGSLAPTGKQMES 
               
               
                 TDRPAVDGRWKKRRSRTTVEALKKTAKSA (SEQ ID NO: 189) 
               
               
                   
               
               
                 &gt;3300005841|Ga0068863_100041042_2 
               
               
                 [plants-rhizoplane-switchgrass rhizosphere] 
               
               
                 MPRARKEKSPTKIYTYGLLPPEHGGEDLMRMLRAGHNYRNALLEVERDRLAETEDFWAKRGRYTELVARVRELEAV 
               
               
                 RFPRKDDPRRQAHYDLIDDLREKVREKREATIQGSLPAEEGRRRLRSRELKAEAKKRGETLTKEQMTRLLDREPGC 
               
               
                 VSVRRKAQLDYEAQSRARGVEPSPKGMVAHLRALGLNTITQEIDDRATQKAKKAREHFKVYYGTYLLIEAQVERAL 
               
               
                 EKTQFPRFKRWTGEGRVGAPVDTNFGLSVDSIHDCQFDSKHGWEENRGNTVLQIDPVGVSCAKGFHTRARVCVDSR 
               
               
                 GRSGSKRLSVWVDFRINYHRELPRGAKICGAWINIYTLGTRVKYELQLQVQDDSFQVQPRHGTGVAAINLGYRSSG 
               
               
                 RVAYVLSEDGKGRELLVSPRIEASIGRADTSRSDRENSANRMCDMLLGWSSELGFPEAFLVGDGESKIDTWSGSVT 
               
               
                 RRSRSLSTRISALKDAREESLSNKLRGILGTWAKLRQDKQTRPSDEATYAAFVEWFHQDKIYQNNEAFTRSGARNY 
               
               
                 RDQVVRDWAHELCDRYEMLLVDGTDYAKLKMRPKDKSVMPIENQTEIAHRRDNFAPGNLRSIIEEVARARGVTVDR 
               
               
                 HDPSGLTQRHHACGWDEPWDAMPRIEHKCAGCGETFDQDANFCVGLFERFRGILPPAPARSPRTSRKNRSSSGSER 
               
               
                 AGGGQEAAE (SEQ ID NO: 190) 
               
               
                   
               
               
                 &gt;3300013306|Ga0163162_10000022_153 
               
               
                 [plants-rhizoplane-switchgrass rhizosphere] 
               
               
                 MNRVYEYGLLDPVVNAQIVEDQLRAAHRYRNLLVEIERERRTRVREILSSHADAAPLAEDVARLTVELEQAQAKIK 
               
               
                 QVRAVSRRRSETTDDRMAVRDVTTRLKAAREQLKIVKAAVAQDPSCQEALAQAEQRCHDRRIEERARCGVFWGTYL 
               
               
                 LIEEDVDRARKGKMDPKFVRFTGEGRVSVQLQGGLEWGGIAEDTRIQIRDAPDPRQGRRAGTRKWLRLRVGSTGRD 
               
               
                 PIWAEWPLILHRPLPEGAVIKRATVTRWRRDCRRWEWRLQLILDVSRCVGTKPRGTEGACALNLGWAKTERGLRVG 
               
               
                 FVVGSDGERTEIVLPGSILDRLDKANAIRAQRDQNLDVMKPLLAAWIAAHPLPEVLHAKIEHLHAWRSADRFFGLA 
               
               
                 RLWRQHRFDGDTEGYELLESWRYRDEHLQRYEAGMRRGALGHRREVYRLVGAALSRRYRMLIVDDTDLRTFQRSPA 
               
               
                 PESDRVEFDAVKRSQHVAAPSDLRMQLANAFGEDGVAELSAVDVTRRCHACLTLNDWDRASSGREHACVGCQQVWD 
               
               
                 QDVNACLNLLREWRTVAPGWEAARVAKASNRQASRAERLQQARRKKKPAEAIAG (SEQ ID NO: 191) 
               
               
                   
               
               
                 &gt;3300009148|Ga0105243_10000126_60 
               
               
                 [plants-rhizosphere-miscanthus rhizosphere] 
               
               
                 MPVIVYEYGLSPPKVNAALVEEQFRLAHKYRNMLTEIELERRTKIRAIMASHPDMVPFETELAEVQAEIEKLRGEI 
               
               
                 NAIRMAARKRASTPEQSRRIKTLAARARELRTEIKERRKRVAAELAPDLKAIQDAAVQRRKDERAKSGVYWGTYLL 
               
               
                 QEAAADQARDQPMPPKFTRWNGDGRVSVQIQQGLAKEGLWGESRQVQIATRIDSLVYDHEVTRRGDRRRLYRTTLR 
               
               
                 MRVGSTDRQPVWAEWGIAMHRPIPDGAVIKVVTVSRRRCNSTQWWWRVQFTLDTTDCKPRQRPEYGVVACNLGFSQ 
               
               
                 TDSGAIRAGYLVGDDGFEQEILVAKSDLYRGRDLTPEQKQKAMTYVRDCLAESSEIRGARDKSLAEFKTRFLEWYQ 
               
               
                 IAKATTFGEDAIPEWFRDRMEHFHMWRSPARVREMMLHWASNRWAELDDPESRWPDSRGFEMMSTWVDEDTKAEVK 
               
               
                 ESSLRNKALGDRREAYRIVAATLAKRYKTLLIDDTNLKHLQDGPEPEDAEGDIPAVKYQQRLAAGSELRQVLINAF 
               
               
                 GGTNVVKMKPSNMTVTCSGCGARDVSWDRADGFRKHRCSACREIWDQDANFCRNLLKEYARGEAPEAKVAKPSRSQ 
               
               
                 RFHESRKKKAAADQQEQG (SEQ ID NO: 192) 
               
               
                   
               
               
                 &gt;3300006846|Ga0075430_100000057_67 
               
               
                 [plants-rhizosphere-populus rhizosphere] 
               
               
                 MATIVYRYGVRTRTETGRYDLPAEVWQQIHLSHRLRNALVEVEHRHDEAMRDLWSAHPQVAEVEQRLAAAEQMVAE 
               
               
                 LIDQARLEHSQDRTTATRRGTATNLREARRAVRDARAARRAAIGEAYPVVKPGIEAVRAARKAAIKDLYREYCQDG 
               
               
                 DLYWATYNAVVADHRIAVQAVERKRRQGQAAQLRYQRWDGTGTISVQLQRQAGQPARSPELLASGDGQWRNVLQVR 
               
               
                 PWMPPEQFDGLTRGERKRHGRGEAVWSVGGGRTVTLPIQVHRMMPADADVCEAQLVVTRTGAHWSAALCVTVRLPD 
               
               
                 PDPVEGRSPLALHCGWRHRPDGSVRVGTWASPEPLVPPANLADVLAAHDSGRWGEIVIPASWLELAGRPAALRSRR 
               
               
                 DLALEPVQRKLAEWLDQNPQPDGDDGRPGLTGGDVRRWRSANRFAALAIRWRDTPPPGEGAAEMTAVLEAWRRQDK 
               
               
                 HLWEWEAHSRARLRGRRDDAWRKVGAWLAEQAGVLVVDDVDLAALRQRGDVADDDPVLPGTAAGQARARAALAAPG 
               
               
                 RLRQCATGAADRRGVAVRTVESGYLTRTCPHCGERGDAHPRYAQSAVVTCPSCGRSYDQDRSAATLMLDRERSGDG 
               
               
                 PGKGERSQQ (SEQ ID NO: 193) 
               
               
                   
               
               
                 &gt;3300006853|Ga0075420_100000070_3 
               
               
                 [plants-rhizosphere-populus rhizosphere] 
               
               
                 MATIVYRYGVRTRTETGRYDLPAEVWQQIHLSHRLRNALVEVEHRHDEAMRDLWSAHPQVAEVEQRLAAAEQMVAE 
               
               
                 LIDQARLEHSQDRTTATRRGTATNLREARRAVRDARAARRAAIGEAYPVVKPGIEAVRAARKAAIKDLYREYCQDG 
               
               
                 DLYWATYNAVVADHRIAVQAVERKRRQGQAAQLRYQRWDGTGTISVQLQRQAGQPARSPELLASGDGQWRNVLQVR 
               
               
                 PWMPPEQFDGLTRGERKRHGRGEAVWSVGGGRTVTLPIQVHRMMPADADVCEAQLVVTRTGAHWSAALCVTVRLPD 
               
               
                 PDPVEGRSPLALHCGWRHRPDGSVRVGTWASPEPLVPPANLADVLAAHDSGRWGEIVIPASWLELAGRPAALRSRR 
               
               
                 DLALEPVQRKLAEWLDQNPQPDGDDGRPGLTGGDVRRWRSANRFAALAIRWRDTPPPGEGAAEMTAVLEAWRRQDK 
               
               
                 HLWEWEAHSRARLRGRRDDAWRKVGAWLAEQAGVLVVDDVDLAALRQRGDVADDDPVLPGTAAGQARARAALAAPG 
               
               
                 RLRQCATGAADRRGVAVRTVESGYLTRTCPHCGERGDAHPRYAQSAVVTCPSCGRSYDQDRSAATLMLDRERSGDG 
               
               
                 PGKGERSQQ (SEQ ID NO: 193) 
               
               
                   
               
               
                 &gt;3300006854|Ga0075425_100000037_57 
               
               
                 [plants-rhizosphere-populus rhizosphere] 
               
               
                 MIVYKYGALKPKVIGGTFEDLLQYQRHSNAFYNALIEIERWRIAARDIVELAQSAPLSDEQKTEHRLAYNAACRAA 
               
               
                 GAATPIGWGQKQAVTEMVAAAMKTRRSDEFKARQRASKKGYDFLKRVMTCARPRHRRFDGEGILAATVQGATGLKA 
               
               
                 SAVLTKPGPVQISGDGKHRTVTLRLREGLSLEVPIVYHRPLPERAEKEGVPYDVRVIFARLVIDRIGDRWTYSVHL 
               
               
                 TIDAAPRVHVAQGGLGRCAVNFGWRRVPGGIRVAYAVDDDGNETSCVFPDALLGRQKHAESLRSLADEIAAAYLGD 
               
               
                 AARRTKARCSALADPDAIHRELGREWFTMEQAAKRDGTDAEHWARRDRHLYQWERDEYASVLRARREIYRLWARKL 
               
               
                 AASYDSVIIEAFDMRSVVKRTPSEDDIPAARHYRFLVGPHCLRLEIQSVFGARCEVLKPAKRTLTCHACGALCKWD 
               
               
                 KARELRHDCESCGAAWDQDANNAKNQLLDAAE (SEQ ID NO: 185) 
               
               
                   
               
               
                 &gt;3300006903|Ga0075426_10000611_28 
               
               
                 [plants-rhizosphere-populus rhizosphere] 
               
               
                 MKRRTSPLPTRIWSYGCLRPTTNTDAFFDQLRKAHVYYNTLIEIERDRRAEYRKDRAKLCPDIEKFEAEFLELDKA 
               
               
                 VDLFRATMKAEKKKKDDTGELKRLKDARKAIGEKLKALRLEMKNSPELKKLQEKEKEVVSGKVRAARKSSGVYWGT 
               
               
                 YLLIEKAVETARRSKMDPRFAKWRGTGRIGIQLHHVKWSDIVDGKSQMFQVDPLPETQWDTRKGRRHAYTKARVRV 
               
               
                 GTEKSATTGKQVPVFVEVPLYLHRRPPADAKLTWAWIFVTRKGPTLRYQLQLSVESNLFSAGLPEQPKKSVCAVDV 
               
               
                 CWRKMDHGLRLGLAVDHHGNQFEMVLPKAVPELIEMGDNMKSAADRIFNGTKDFVSKWIKENGLPGAIEPARVSQW 
               
               
                 LSHRKLRGLTRQWLAETIGFERARELWRAWCFERVGSRKNPLTVPKKDLFAPAEEAFAWAEKHGLTKPFEQMAFYL 
               
               
                 ELWSRKDRHLEQWAADQFYRATMIRRDAFRNWSRFLVNNYETILLEDMTHTTFAKDSVVEAEKSFDVLHRQRNEAA 
               
               
                 PGLFMQTLRSAVGAHVVPMDPADTTNDCAHCRHRNDWSQTERSKNVVLTCAGCGKMFDQDANAARTMLIRYFEGDT 
               
               
                 GSGGSKDKPKPASPPPSKPPPRALTKRRKPGAEPRASV (SEQ ID NO: 194) 
               
               
                   
               
               
                 &gt;3300006914|Ga0075436 100000782_9 
               
               
                 [plants-rhizosphere-populus rhizosphere] 
               
               
                 MKRRTSPLPTRIWSYGCLRPTTNTDAFFDQLRKAHVYYNTLIEIERDRRAEYRKDRAKLCPDIEKFEAEFLELDKA 
               
               
                 VDLFRATMKAEKKKKDDTGELKRLKDARKAIGEKLKALRLEMKNSPELKKLQEKEKEVVSGKVRAARKSSGVYWGT 
               
               
                 YLLIEKAVETARRSKMDPRFAKWRGTGRIGIQLHHVKWSDIVDGKSQMFQVDPLPETQWDTRKGRRHAYTKARVRV 
               
               
                 GTEKSATTGKQVPVFVEVPLYLHRRPPADAKLTWAWIFVTRKGPTLRYQLQLSVESNLFSAGLPEQPKKSVCAVDV 
               
               
                 CWRKMDHGLRLGLAVDHHGNQFEMVLPKAVPELIEMGDNMKSAADRIFNGTKDFVSKWIKENGLPGAIEPARVSQW 
               
               
                 LSHRKLRGLTRQWLAETIGFERARELWRAWCFERVGSRKNPLTVPKKDLFAPAEEAFAWAEKHGLTKPFEQMAFYL 
               
               
                 ELWSRKDRHLEQWAADQFYRATMIRRDAFRNWSRFLVNNYETILLEDMTHTTFAKDSVVEAEKSFDVLHRQRNEAA 
               
               
                 PGLFMQTLRSAVGAHVVPMDPADTTNDCAHCRHRNDWSQTERSKNVVLTCAGCGKMFDQDANAARTMLIRYFEGDT 
               
               
                 GSGGSKDKPKPASPPPSKPPPRALTKRRKPGAEPRASV (SEQ ID NO: 194) 
               
               
                   
               
               
                 &gt;3300007076|Ga0075435_100000061_47 
               
               
                 [plants-rhizosphere-populus rhizosphere] 
               
               
                 MKRRTSPLPTRIWSYGCLRPTTNTDAFFDQLRKAHVYYNTLIEIERDRRAEYRKDRAKLCPDIEKFEAEFLELDKA 
               
               
                 VDLFRATMKAEKKKKDDTGELKRLKDARKAIGEKLKALRLEMKNSPELKKLQEKEKEVVSGKVRAARKSSGVYWGT 
               
               
                 YLLIEKAVETARRSKMDPRFAKWRGTGRIGIQLHHVKWSDIVDGKSQMFQVDPLPETQWDTRKGRRHAYTKARVRV 
               
               
                 GTEKSATTGKQVPVFVEVPLYLHRRPPADAKLTWAWIFVTRKGPTLRYQLQLSVESNLFSAGLPEQPKKSVCAVDV 
               
               
                 CWRKMDHGLRLGLAVDHHGNQFEMVLPKAVPELIEMGDNMKSAADRIFNGTKDFVSKWIKENGLPGAIEPARVSQW 
               
               
                 LSHRKLRGLTRQWLAETIGFERARELWRAWCFERVGSRKNPLTVPKKDLFAPAEEAFAWAEKHGLTKPFEQMAFYL 
               
               
                 ELWSRKDRHLEQWAADQFYRATMIRRDAFRNWSRFLVNNYETILLEDMTHTTFAKDSVVEAEKSFDVLHRQRNEAA 
               
               
                 PGLFMQTLRSAVGAHVVPMDPADTTNDCAHCRHRNDWSQTERSKNVVLTCAGCGKMFDQDANAARTMLIRYFEGDT 
               
               
                 GSGGSKDKPKPASPPPSKPPPRALTKRRKPGAEPRASV (SEQ ID NO: 194) 
               
               
                   
               
               
                 &gt;3300007076|Ga0075435_100000750_29 
               
               
                 [plants-rhizosphere-populus rhizosphere] 
               
               
                 MIVYKYGALKPKVIGGTFEDLLQYQRHSNAFYNALIEIERWRIAARDIVELAQSAPLSDEQKTEHRLAYNAACRAA 
               
               
                 GAATPIGWGQKQAVTEMVAAAMKTRRSDEFKARQRASKKGYDFLKRVMTCARPRHRRFDGEGILAATVQGATGLKA 
               
               
                 SAVLTKPGPVQISGDGKHRTVTLRLREGLSLEVPIVYHRPLPERAEKEGVPYDVRVIFARLVIDRIGDRWTYSVHL 
               
               
                 TIDAAPRVHVAQGGLGRCAVNFGWRRVPGGIRVAYAVDDDGNETSCVFPDALLGRQKHAESLRSLADEIAAAYLGD 
               
               
                 AARRTKARCSALADPDAIHRELGREWFTMEQAAKRDGTDAEHWARRDRHLYQWERDEYASVLRARREIYRLWARKL 
               
               
                 AASYDSVIIEAFDMRSVVKRTPSEDDIPAARHYRFLVGPHCLRLEIQSVFGARCEVLKPAKRTLTCHACGALCKWD 
               
               
                 KARELRHDCESCGAAWDQDANNAKNQLLDAAE (SEQ ID NO: 185) 
               
               
                   
               
               
                 &gt;3300009100|Ga0075418_10076301_2 
               
               
                 [plants-rhizosphere-populus rhizosphere] 
               
               
                 MTEKPPTKIYTYGLLQPTKNGHEFSKMCRAAHDYYNALLEIERTRQREEDDFWAKRGGYVDLLDEFRQLEAMRPRR 
               
               
                 DDPKREEIFARRKELRKKLWELRDVTVDRSLPIEDANRRNRHRELKKAAKAEGRNITDAEISASLDKDPSCVSPRR 
               
               
                 RAQLEYTEEAKARGVNVSGRGLNQYLRDRGLLKVTQPIDDRAAEDQKRARDHFELYYGTYLLVEPAAEQAIERSEM 
               
               
                 FPAFKPWRGEVGRVGAPVNTNTGISVEAIHNCFNEDPKTGERTFSDGGNTVLQIIPIRKEVRESRRVRVKGAPSAH 
               
               
                 QQGMKFLNQTVMRICVRSEGRVGAQRIPVWVEFPMQYHRDLPPNAKVTAAWVIASQLGTRTVYKLQLQVQDEAFRN 
               
               
                 PVKPCGRSTMAVNLGYRSTGRVAYALTQDGRYEVMDVKDRVGKCIDEADELRSLRDRDANRMRNDLFEWRDVEAYP 
               
               
                 QSFLEGDGEKFVPHWSGDEKRRRSVKVRSMKTRIDGLVHARDDSLPTRLRAIYETWERMREQGLLRSVDDRIFKVF 
               
               
                 REWYIEDKRSQDKEAHQRLNAHGTRELDIYAWAHRLCDEASLILVEDTNYATMKLKSNRRPKEELPVEISVSIARR 
               
               
                 RDMYAPGRMRKILEQVAVKRGVKIVRLSSVGLTQRHHKCGFDEPWDAMRSIQHKCEGCGVTFDQDRNFCEGLFERY 
               
               
                 RGTLPAAPARKAGKGKKSRDLPAEAE (SEQ ID NO: 195) 
               
               
                   
               
               
                 &gt;3300009100|Ga0075418_10076301_2 
               
               
                 [plants-rhizosphere-populus rhizosphere] 
               
               
                 MRSMTEKPPTKIYTYGLLQPTKNGHEFSKMCRAAHDYYNALLEIERTRQREEDDFWAKRGGYVDLLDEFRQLEAMR 
               
               
                 PRRDDPKREEIFARRKELRKKLWELRDVTVDRSLPIEDANRRNRHRELKKAAKAEGRNITDAEISASLDKDPSCVS 
               
               
                 PRRRAQLEYTEEAKARGVNVSGRGLNQYLRDRGLLKVTQPIDDRAAEDQKRARDHFELYYGTYLLVEPAAEQAIER 
               
               
                 SEMFPAFKPWRGEVGRVGAPVNTNTGISVEAIHNCFNEDPKTGERTFSDGGNTVLQIIPIRKEVRESRRVRVKGAP 
               
               
                 SAHQQGMKFLNQTVMRICVRSEGRVGAQRIPVWVEFPMQYHRDLPPNAKVTAAWVIASQLGTRTVYKLQLQVQDEA 
               
               
                 FRNPVKPCGRSTMAVNLGYRSTGRVAYALTQDGRYEVMDVKDRVGKCIDEADELRSLRDRDANRMRNDLFEWRDVE 
               
               
                 AYPQSFLEGDGEKFVPHWSGDEKRRRSVKVRSMKTRIDGLVHARDDSLPTRLRAIYETWERMREQGLLRSVDDRIF 
               
               
                 KVFREWYIEDKRSQDKEAHQRLNAHGTRELDIYAWAHRLCDEASLILVEDTNYATMKLKSNRRPKEELPVEISVSI 
               
               
                 ARRRDMYAPGRMRKILEQVAVKRGVKIVRLSSVGLTQRHHKCGFDEPWDAMRSIQHKCEGCGVTFDQDRNFCEGLF 
               
               
                 ERYRGTLPAAPARKAGKGKKSRDLPAEAE (SEQ ID NO: 196) 
               
               
                   
               
               
                 &gt;3300009156|Ga0111538_10081463_8 
               
               
                 [plants-rhizosphere-populus rhizosphere] 
               
               
                 MQRQKDDSITSRVYVYGCVPERVAPVHNEDRALEQMRLGQRLWNVLVAIDRARVARYRRIMADEAQERIDALRDQA 
               
               
                 AALRDEIKTRRKQARKRSVDIGDLAERLAAVKSELSALIEEQKRTSTERHDARRAELTAMQERTNHRIKRARQAAA 
               
               
                 SLGLFWGTYNDIVQRSDAGRKHGGELHFRGFRGEGTLTAQIMGGAIVTRCVEGAHTFFQVDPPQPGRKWRYARMRI 
               
               
                 GSEERGGVKLAPVWLEIPIVYHRDLPPAGMIKSVSMTRRMLAGKPRWQLNVTLNLPAPKPTTRTAAVAIDIGWRLL 
               
               
                 PEGVRVAYWMDDAGQHGQVLIPSRDISQFERVRSLRSNCDLSRDEILPGLAEWFGGLELPAEWAQRVAYLSQWRSS 
               
               
                 DRLAGLYDWWRDHRLPGDAETFEAYTTWRKQYLHLAHWWRNLQDQMTLRVREQYRVFAAQLAGRYGVVYIEDFDLS 
               
               
                 SVARKPKTEGDGEKSASSTYRQMVSPSMFRGALLNALQREGATVTELPAEYTTRICSTCGYGREWDQAESVMHRCG 
               
               
                 GCGEMFDQDENAAKNLLRLVAQGVAG (SEQ ID NO: 197) 
               
               
                   
               
               
                 &gt;3300005548|Ga0070665_100000073_173 
               
               
                 [plants-rhizosphere-switchgrass rhizosphere] 
               
               
                 MTTLAFKYGLGDPLDWDTDIADQLYLQNKLWNRLVEIERDARTRYRAVVGEDDAIAPLVRDIEAAKAQKEALLTER 
               
               
                 KGLRAKARKRVPTPEIDARIAECATVVRELAQRIKTERVAAKERLAPHVRAIEEWRFGAVKEARNASGLWWGNYNA 
               
               
                 VCASYDTARSRAMKDGAELQFHRFTGEGRLTCQIQGGTTPEQIVDGKCSLVRVDPLSAGAHSHPSRGERRRLQRTK 
               
               
                 IAVTAYMKDGERRLLTLPMQMHRPLPDGAIVKQVVVTRRKIGTRYRWHAVFTCSVPDAQPVQHASTSACGVNFGFR 
               
               
                 QVLGGLRVATVSTSPSKTPDYLVLPEEWLRAMDRCEALQSARDEHLLPMHAAARELTRGEDAPESLRDKLDRIARA 
               
               
                 PKIGSALLASLVLAWRDTHADWQSDKLVGFEAWRRNDKRAAEEQANLRDKLHASRTERYRLWARELVRDHALVGCG 
               
               
                 KIELRKLAELEKQDGTENDLHARARSNRQRVSLYSLQLELARAAQLAGARVVMADGPLTSTCHACGATTLIKPDIM 
               
               
                 QVCDHCSAVWDQDHNAALNALSYAQQSPPPRERSGDAQDTDQENQVFGEPAEEKKDSARNVRLAA (SEQ ID 
               
               
                 NO: 198) 
               
               
                   
               
               
                 &gt;OBLM01000011_1 
               
               
                 [soil metagenome] 
               
               
                 MHSRVYLYGLLPPTPACAPLVEQQMGRAHRYRNVLVEIERERRAKVREVMAAHPDMAPLEEQVNALVAERETALQA 
               
               
                 LPRKAARNDPARANVRAMATRIRDLRGQIKAARKAVLADAEVARQLAEADEFSRERVRRARATCNVYWGTYLLQEA 
               
               
                 DADRARMERMPPKFHRWTGEGRVSVQLQGGLEQDKMWGGDTRMQIDPVAPEAHDPLSPRGVRRRAHRTVLRLRVGS 
               
               
                 DAQRGPIWAEWPMLMHRPLPKGAIIKVATVSRRYRNCTTWDWQVLLTVSIPDESARPAPAAGVVALNLGFCERPDG 
               
               
                 SLRAGYLVGDDGWTQEIVVPASTSELLGKCDSIRSFRDKNLDAMRPLLSAWRQDQNLAFERVCRDVIAACETTPPE 
               
               
                 LDGAFYRLAMYIVNGGHSLPSWLHERIQSVHAWRSHDRFRKLALTWRDRRFPGDHAAYELLEVWRYRDQHLEHYES 
               
               
                 GMRRRTLLRRREGYRIIAAAAAARYRTLLVDDTDLRHFQRKPDPEDGATVPEQIGLATMRVNQRLTACSGLREALA 
               
               
                 SAFGSRVVKMSSQNVSRRCHACGDINLAMSSAREQTCTGCAATWDVDQNACLNLLGEHRRDDPDRETARVAKLANA 
               
               
                 KPSRGKRLSAARASNGATVLAREASGN (SEQ ID NO: 199) 
               
               
                   
               
               
                 &gt;OCTA010000646_37 
               
               
                 [soil metagenome] 
               
               
                 MKRRTSTAPVRIYAYGCRLPTQGGELVEQQLLFRHRYYNKLIEIELDCREKMRAARSASSEDVAHAESAFAIYETE 
               
               
                 IVGVLDAIKAKKGAARAAKVDAAEERAVLAVLRDMKRKTIDDLHAAKLAARTPELLAEFTAIQEAANAEVRDARSK 
               
               
                 CGVYWGTYLLVEQEVEQAVKAARKNHEDPGFRRFMSVPNRQGQATIARGRVGVELIHGVPVATIMAGTDTRLQIHM 
               
               
                 EKSDSKRGQTMARAKIRVGTAENGRSPIFAEFPFRMHRPLPADGVVKWAWISKSTKGRWVDWSLQIVVEAASLHRP 
               
               
                 VRQPSDGGVVAFDIGWRVRLHEVVNELRVAYWHDDQGNHGELVLPSDDRVRVDSRGRKHRPEGVRGRFDHVDSLRS 
               
               
                 IEDKNFDAIRSELVAWKTGRDLPEWFVSALEWLHAWKSHRKLGAVFDQWRSNRFSGDDGMFAKVETWWKQHRHLYD 
               
               
                 WESCERDRALNARKNTFRQWAPQFTRKYAVVVLEEKFLAEVAKLQAPDSTKANMPRPTRRNRTVAACGEFVLALKN 
               
               
                 AAPGNGCTVDAEPCEDTTATCARCGYVERFDHRPLAHACARCGDVSGPVDQDRTAAENLLAAYAGKMSRSQSASEG 
               
               
                 GNIVGDPDGSLVIPAQEGVS (SEQ ID NO: 200) 
               
               
                   
               
               
                 &gt;ODAK010001378_33 
               
               
                 [soil metagenome] 
               
               
                 MIRVYRYGVASPHDGADLVYAQMRGAHAYRNTLIEIERGRRGALRDLESAEVRGLTAEVAAADEACQAIGSTIKVA 
               
               
                 RAESRKRSERKVDLERLAEARSVKRAITGRLYEARRNHMLATRSAVDIVNELAKCLLKSAREHCGVYWGTYLLAEE 
               
               
                 AMGASSSAPLFGKDGITQNDPKFIRWTGDGAVRVQIQKGASVAAVRADAEHSQLQIREPTGAWSHPTRSERRRLAK 
               
               
                 RGEVRIRVGSEPNGKPVWAAWRLDMHRPLPEEARIKEATIHVRQRGAHSEWSLLVTVDVPPAAVVPSESRGEAVGV 
               
               
                 DVGWRLIDGCIRVAVCMGAGGAVTELRLDAPTIRLLRSSEALRSKRDERFNAAKARIRKAAAEPVAPEWLRESGKT 
               
               
                 MHAWRSPQRLAQLHARWAEERFSGDDMVFGRLEAWWWTDRHLWSTEAQASLQGHRRRKDIYRVFAAKLAARYDVIV 
               
               
                 LEKFDLRKVARTEETGEETPAGDNDTSRSNRQLASVSEFRACLLDAARSRGRSVVMVDASETTRTCHVCGLVEAFD 
               
               
                 AAAHLRRTCACGSEWDQDENAAEVILARWRERPGDAKILVPARSTEIYCETMELLETRWQRVARLRKEKLARMDTA 
               
               
                 RKSASNAAE (SEQ ID NO: 201) 
               
               
                   
               
               
                 &gt;ODAK010029943_5 
               
               
                 [soil metagenome] 
               
               
                 MMVFKYGTVPARIAPVIGAEQAAIQLRLANRLWNLLVAIERARVARYRKVMFDAAQGRIELLKAKLSALRGKIQVR 
               
               
                 RQAGRRRVDVSDLTAESQEIRAAIKAEIKAHKATSAERHDARRAELDALSETSKSRIKRARQAAASMGLFWGTYND 
               
               
                 IVQRADVGRRAGELHFRRDTGDGTLTAQIMGGADPEECMTAHSFFQIASKCPLSGLVAGDVAETDAQPVKWQYARM 
               
               
                 RIGSTGERQPIWLAIPIVLHRPLPDGARIKSVSMTKRKTTWSLNVTVAEPAPTPKLIGPRVAIDLGWRVVPSGVRV 
               
               
                 AYWADTLGGEGQVVVSDEDIGQFGRVRSLRSRCDTMRDEYLPVLAAWTSGRELPAEWQAETIALVQWRSPDRLARL 
               
               
                 IRWWARLPGDAEMFSRASAWRKQYLHLANWWRNLEDQMRGRLREQYRIFAAGVAKKYSTVYLEVFHLPDVIETPAA 
               
               
                 ESEEVRTAESRYRQMVSLSVLRAAVRNACTREGCTVVDVAPEYTTLGCHLCGTITEWDTAASLMHQCKGCGAVWDQ 
               
               
                 DQNAAINLLARGASGGAPPTANQPDRPRKWDRVRDRSRKSAQAAESAILAAAAVEMPAQRLSC (SEQ ID NO: 
               
               
                 202) 
               
               
                   
               
               
                 &gt;ODAK010029943_6 
               
               
                 [soil metagenome] 
               
               
                 MTKPLSGLVAETGLLFRAFRAARPSSKCLLSGLVVETECDNVVMMVFKYGTVPARIAPVIGAEQAAIQLRLANRLW 
               
               
                 NLLVAIERARVARYRKVMFDAAQGRIELLKAKLSALRGKIQVRRQAGRRRVDVSDLTAESQEIRAAIKAEIKAHKA 
               
               
                 TSAERHDARRAELDALSETSKSRIKRARQAAASMGLFWGTYNDIVQRADVGRRAGELHFRRDTGDGTLTAQIMGGA 
               
               
                 DPEECMTAHSFFQIASKCPLSGLVAGDVAETDAQPVKWQYARMRIGSTGERQPIWLAIPIVLHRPLPDGARIKSVS 
               
               
                 MTKRKTTWSLNVTVAEPAPTPKLIGPRVAIDLGWRVVPSGVRVAYWADTLGGEGQVVVSDEDIGQFGRVRSLRSRC 
               
               
                 DTMRDEYLPVLAAWTSGRELPAEWQAETIALVQWRSPDRLARLIRWWARLPGDAEMFSRASAWRKQYLHLANWWRN 
               
               
                 LEDQMRGRLREQYRIFAAGVAKKYSTVYLEVFHLPDVIETPAAESEEVRTAESRYRQMVSLSVLRAAVRNACTREG 
               
               
                 CTWDVAPEYTTLGCHLCGTITEWDTAASLMHQCKGCGAVWDQDQNAAINLLARGASGGAPPTANQPDRPRKWDRV 
               
               
                 RDRSRKSAQAAESAILAAAAVEMPAQRLSC (SEQ ID NO: 203) 
               
               
                   
               
               
                 &gt;3300005602|Ga0070762_10000001_34 
               
               
                 [terrestrial-soil] 
               
               
                 MKLVYKYALASPHENFDLIDLQMRAAHRYRNTLVEIERGRRAAVRLVEAEAGDMPAAQRALTMAIGARELADGAIK 
               
               
                 RHRARSRKRDEPQEMRDTLRAARVAERDAAKAFRELRLKIKDSPAMIAARDAIGERAKELQRSARANCGVYWGSYL 
               
               
                 LVEGAVSDSFSDTSLYNKDGHANDPAWARWTGEGSVGVQIQTATADKATKSLTVERAASGNDSRLRIVLPDERAWD 
               
               
                 RSGRTHRECENMARQAQLSIRIGSNGRDPVWGSWRMDMHRPLPVGSTIQLATVHRKRVGPYDRWHVTFTLDVPAST 
               
               
                 RASTAGTGTIAVDVGWRVMGDELRVAGWQDDTGDRGELRLSAKDLAVLRAPEAMRSARDLRFDAARLALSVWLRDH 
               
               
                 REILPDWLRVISANVHAWKAEARMVALRNRWMDARFADDEAAYDALTNWAFRARHDWAVESCARGQALRRRREKYR 
               
               
                 VWAAQLATKYDTIVIENFDKRRVAATSRDATTENETARANRVLASTSELVSCMETAARSRRAALFAVPCADTTRTC 
               
               
                 PTCGLVESRDAAAAVRLECECGARWDQDVDGAPLVLLARWRERPGDAKIVVSAREQEKTNENGEKKEGRWAKVARL 
               
               
                 RAEKVARMATAREADADGAE (SEQ ID NO: 204) 
               
               
                   
               
               
                 &gt;3300005602|Ga0070762_10000001_32 
               
               
                 [terrestrial-soil] 
               
               
                 MWSIGASVATRCCRRRPSDRYGSDKRNKEIVTMKLVYKYALASPHENFDLIDLQMRAAHRYRNTLVEIERGRRAAV 
               
               
                 RLVEAEAGDMPAAQRALTMAIGARELADGAIKRHRARSRKRDEPQEMRDTLRAARVAERDAAKAFRELRLKIKDSP 
               
               
                 AMIAARDAIGERAKELQRSARANCGVYWGSYLLVEGAVSDSFSDTSLYNKDGHANDPAWARWTGEGSVGVQIQTAT 
               
               
                 ADKATKSLTVERAASGNDSRLRIVLPDERAWDRSGRTHRECENMARQAQLSIRIGSNGRDPVWGSWRMDMHRPLPV 
               
               
                 GSTIQLATVHRKRVGPYDRWHVTFTLDVPASTRASTAGTGTIAVDVGWRVMGDELRVAGWQDDTGDRGELRLSAKD 
               
               
                 LAVLRAPEAMRSARDLRFDAARLALSVWLRDHREILPDWLRVISANVHAWKAEARMVALRNRWMDARFADDEAAYD 
               
               
                 ALTNWAFRARHDWAVESCARGQALRRRREKYRVWAAQLATKYDTIVIENFDKRRVAATSRDATTENETARANRVLA 
               
               
                 STSELVSCMETAARSRRAALFAVPCADTTRTCPTCGLVESRDAAAAVRLECECGARWDQDVDGAPLVLLARWRERP 
               
               
                 GDAKIVVSAREQEKTNENGEKKEGRWAKVARLRAEKVARMATAREADADGAE (SEQ ID NO: 205) 
               
               
                   
               
               
                 &gt;3300006796|Ga0066665_10000988_15 
               
               
                 [terrestrial-soil] 
               
               
                 MSEQLDDTPEQPNEVEETKKRKQRNKGKHPARIWSVFSRYLVSGREHFDKQVLLAHRFRNKLVELELQRRAAANVV 
               
               
                 IAQASSELQPLIDALAAAEQVLEVSLQELKAVRAKHRRRAESAAQRDAVTNARTARNQASKALSKARKDAFASEAA 
               
               
                 QVGLWLAEEHHFQAVLAARHAFINDGLYWPTATDVQDRARAMRKGAPPVFRRFGGAEQAGRIAVQIQQRTDKSQSE 
               
               
                 GGITFEEAFSCSHGFFRLEKKPGRDPLPEIADQPDYKSKRQQLLTYARAWLRVGSEGKGARAKPCWVVADVLLTRQ 
               
               
                 APKTARIVQVYLDHSVIGDRERWRLSLVLTNQEGWPKPNRASGCMVGIDLGWRLLDTGELRVAYACGADGQHHELR 
               
               
                 LPASLVKVWRRPDRIQQERDNLFNDVKARLLEWLKGREDLPDWLKEQAEHLHLWKSSTRLSRLVDHWAGRDINWSS 
               
               
                 QRRIAGDEEILASLRGWVKRNLHLRDYQYHEREQLAAHRLDVYRKWADGLARLYQTAVLEDADWRDLARLPSPEDD 
               
               
                 AVNETARYNQRMASPGLLASVITNMFAITSRVECANTTRECWRCGHTEAFDAEAQLIRVCPGCGDACDQDESAARV 
               
               
                 LLARGQALNQSQVAEAAPSS (SEQ ID NO: 206) 
               
               
                   
               
               
                 &gt;3300018429|Ga0190272_10000030_113 
               
               
                 [terrestrial-soil] 
               
               
                 MAVVVHVYGVPPVLHGERVRLPAEVDEQLSLAHCLREDLVTLEHQRQDAVTAVWSSYPQIAAIETQLTAAETELTD 
               
               
                 RSAAAAAERSAARKKGPTESSEAVRQLKARIKDLRSQRRTAIADAHPTATPRLTAIADAHRAAIKALYADYSQGRG 
               
               
                 LYWATYNDVVAHHQVATKRVAAERKAGRPANIRHHRYDGSGSITVQLQRQTGAPPRLPATIADEQNGPWRNVLYLT 
               
               
                 PWVDPDTWATLARAEQRRRRLGVVRLDLGNKRHLSIPVLVHRMLPADADITSARLVVRRVAGHRKIELHVTARIKD 
               
               
                 PVTRSGGPAVALHLGWRREDGGAVRVATWRSTAPVHVPDDLNDLVHADTDHTGTISLPARWWHRVSTQPEMAARRA 
               
               
                 TSLNDIRDQLVAALTDNPLTITADDEDAQPVPTAAAVATWRSPARFAHLARTWATDCPAGHQATAAALENWRRSDR 
               
               
                 RLWEQQAHGTANTLAARADAYRRTMSWLLTGASRLVLDNTAIADLARRADPATEPTLPTAVTDRVAHQRIGASPGQ 
               
               
                 LRSIATTTANSYGVAVAVMPHTGITRTHYRCGHLNPADDRYSAARIVTCDGCGQHYDQESSATLMLLAASGDVAAP 
               
               
                 GSATARNPDTSAHA (SEQ ID NO: 207) 
               
               
                   
               
               
                 &gt;3300018432|Ga0190275_10000082_154 
               
               
                 [terrestrial-soil] 
               
               
                 MTTLEARVAQYGCLAPIENADVVRQQMRLGARYYNELIALERCRRAVYRDLRRKYVDLESVEARVEELAAELMSLR 
               
               
                 EAIKGVRKEARRRVDTADLDQRAKDVQSALRVARVALKDARQAARDNAELRAAVEQLDERAKIWSKALRAMRAPWW 
               
               
                 GTYLLEEASAEQARKATIDPSFRRARGRERISAAGEGSAEGRIGVQVQGGMTVAELYGCEDTRLRIEPVSPDAWHA 
               
               
                 SSRGVRRRCSRTRLWMRVESAGRSPVWAVFPLILHRPIPDDARIKGAVVRLRVLGFREQWTVSVTYAREPAVMPER 
               
               
                 PGIVALDLGWRQRPDGSLRVAYCADDQGNHREVVMPESVRMRLRKARDLREIQDLHFNRAVRWLARWLDAGKAPEW 
               
               
                 LARERPHLGQWRSHGRLRRLVLDWRRTRFVGDERIFAAMERWLHRSRHLYQWEVDAQRKALLARRELYRCTAAQIA 
               
               
                 RAYGRVVIEQFDLATAKRLKAPEQGEDAPLAQRAQLHASAPGEFRQCLTQAVQREGGLVISVDASGTTSHCHACGG 
               
               
                 VCSWEQGEELWHRCEYCGELWDQDHNAAINLLRRFTRDHSGDATNPAPARKPSKRAERFRKRHAQPAATDVAE 
               
               
                 (SEQ ID NO: 208) 
               
               
                   
               
               
                 &gt;3300018481|Ga0190271_10027355_3 
               
               
                 [terrestrial-soil] 
               
               
                 MELNAKPDDLELDDDIPAGEEEEEKPDLDARVAQYGCLWPIQGEDLIRQQMRAGHQYMNNLIFIERCRRTCYRDLR 
               
               
                 REHANITEIEDLCQTLAHELDELRDQIKGARKAARSRVETKELNAKAAEVLKRLQPARKELKAARTAAAQNEVLKA 
               
               
                 AVKELDARVLLCQKFLRKQTDCFWGSYILVEASMKQVKKSKIDPYFRRWKGEGRIGVQIQHGMTVQRALDGVDRRL 
               
               
                 RIMPAPTSFLGENKSASHARHKARHLLYIRVDSEGRYPVWAVFPMIMHRDMPPDALIKGVTVHCRKRGLRDKWSCD 
               
               
                 ITFTKPAVKPAKKPGVVAIDLGWRKRPDASLRVAYWVGSDGQDGEIRMPERVSRRLRHSDGLREVQDLSFNRMKSR 
               
               
                 LKLWLNAVDARDETLDKPMVPDFLTAIQPHMDKLRSHERIRKLVKQWEHERFEGDEHIFWAVKQWFRSSIHLYPWE 
               
               
                 VSQRKSTLRYRREMYRLAALELSKRYGTLVLENFDLSKAKRKNAPEQGPDAPKAQRTQLHASAPGEFRQALVQVFL 
               
               
                 REGGEVFRVDAMGTTSSCHACGATCKWDQAEEISHRCEHCGTLWDQDYNAAKNLLLRYALPQAS (SEQ ID NO: 
               
               
                 209) 
               
               
                   
               
               
                 &gt;3300019874|Ga0193744_1000265_21 
               
               
                 [terrestrial-soil] 
               
               
                 MIVYKYGALKPKVIGGSFDDLLAYQRDSNVFYNALIEVERWRIAARDIVEMDQAGPLSDEQKTEQRLAYNAACRAA 
               
               
                 GQASTIGWGQKQAVTEMVAAAMKTRRADEFKARQRATKKGYDFVKRVMTCARPRHRRFDGEGLLAATVQGCSGLKS 
               
               
                 SAVLSKSGPVQISGSGKHRTVTLRLREGLSLEIPIAYHRPLPERAEKEGVPYDVRVIFARLMIDRIGDRWIYSVHL 
               
               
                 TIDAAPRAHAAQGGLGRCAVNFGWRRVEGGIRVAYAVDDEGNETSCVIPDSLIGRQKHAESLRSLADEIADAYLGA 
               
               
                 AARRTKSRRQALASPDATHPGLGKIRFTLGQAANHAPEDAEHWARRDRHLYQWERDEYASVLRSRREIYRLWARKL 
               
               
                 AASYDSVIIEAFDMRSVVTRAPNKDNIPAARHYRFLVGPHYLRAEVQSVFGKRCEISKPAKRTLTCHACGALCKWD 
               
               
                 KARELRHDCESCGAAWDQDANNAKNQLLDAAE (SEQ ID NO: 210) 
               
               
                   
               
               
                 &gt;3300020021|Ga0193726_1013919_1 
               
               
                 [terrestrial-soil] 
               
               
                 MIKNYEYGLLDPTANAQLVDDQMRAAHRYYNQLVEIERERRAEIAAILVGHPDTEALAARVADLARQREEARLAIK 
               
               
                 ATRQATRDRSETSQMRDRVKDLATELRAARATLKTARDVIKTDAVIVAAISACDDRATTRVKARRAACEAYWGSYK 
               
               
                 LSEEAVDAAKKAKAPPHFKRWTGDGRVSVQLQGGISDGELFGTDTQVQVAPVSPDAHDLRKPRGVRRLASRTILRL 
               
               
                 RVQSTEKGRPIWAEWPMILHRPIPEGARVKIATVSRRRRDCRRWDWRVLLTLEIPDGASEHRRLIPASGAIALNLG 
               
               
                 WCKRPEDAVRAGYVLSDDGVIDREVIVPPSTINRVEKSEAIRSQRDKDLDAMRVTLVAWLRAHEAGLPAWVVERTI 
               
               
                 LSREPRAVPQVDTPRAEAVRDASQRTRAWHVAQWRSAARFRALAFAWRSQRFDGDGEGYQVLEDWRYRDEHLERYE 
               
               
                 SGMRRGGLLDRRERYRMLAADLAARYRTLVVDDFDLRTFAEIPKPEDESANVKPHRKQQRYAAGSELRAALLNAFG 
               
               
                 PTRVLRESSVDVTRACAAIVVDEATGAEHTCGQLDLWDHTVAREHTCSGCGATWDQDQNACKNLIGRWRERLGADG 
               
               
                 SVETARVATPRKESRSERLRRTRWKREPEAEAASTTEPHPSPSRVAPVAPATAAPTCQKSPIVTDGAATITATAPP 
               
               
                 PSPLRAPSPVVPGQSAVRANRPIAAPG (SEQ ID NO: 211) 
               
               
                   
               
               
                 &gt;3300020021|Ga0193726_1013919_1 
               
               
                 [terrestrial-soil] 
               
               
                 MEISRASGSHRVMPMCTQPVHACQCLQERATWDHVIKNYEYGLLDPTANAQLVDDQMRAAHRYYNQLVEIERERRA 
               
               
                 EIAAILVGHPDTEALAARVADLARQREEARLAIKATRQATRDRSETSQMRDRVKDLATELRAARATLKTARDVIKT 
               
               
                 DAVIVAAISACDDRATTRVKARRAACEAYWGSYKLSEEAVDAAKKAKAPPHFKRWTGDGRVSVQLQGGISDGELFG 
               
               
                 TDTQVQVAPVSPDAHDLRKPRGVRRLASRTILRLRVQSTEKGRPIWAEWPMILHRPIPEGARVKIATVSRRRRDCR 
               
               
                 RWDWRVLLTLEIPDGASEHRRLIPASGAIALNLGWCKRPEDAVRAGYVLSDDGVIDREVIVPPSTINRVEKSEAIR 
               
               
                 SQRDKDLDAMRVTLVAWLRAHEAGLPAWVVERTILSREPRAVPQVDTPRAEAVRDASQRTRAWHVAQWRSAARFRA 
               
               
                 LAFAWRSQRFDGDGEGYQVLEDWRYRDEHLERYESGMRRGGLLDRRERYRMLAADLAARYRTLVVDDFDLRTFAEI 
               
               
                 PKPEDESANVKPHRKQQRYAAGSELRAALLNAFGPTRVLRESSVDVTRACAAIVVDEATGAEHTCGQLDLWDHTVA 
               
               
                 REHTCSGCGATWDQDQNACKNLIGRWRERLGADGSVETARVATPRKESRSERLRRTRWKREPEAEAASTTEPHPSP 
               
               
                 SRVAPVAPATAAPTCQKSPIVTDGAATITATAPPPSPLRAPSPVVPGQSAVRANRPIAAPG (SEQ ID NO: 
               
               
                 212) 
               
               
                   
               
               
                 &gt;3300020034|Ga0193753_10002988_10 
               
               
                 [terrestrial-soil] 
               
               
                 MKEIRVYKHWAEPASAVDHHRLQSQLKLAYQYRRMLAMIENAARVAQRALVQADPAIAMLINQLAVLHEADPPATI 
               
               
                 VITAAQEALRLARRDLHKTDAYKLEARAIGDRRQVLVRGARGLFSAQGLAWGTYQHVEEAHDQSCSENPYWEDVKV 
               
               
                 RLTPGFGAIAVHIQNRVLPSGTLVGGRDTFVQIDAERYGLSTFRNGWRAIDPDGPSGRVQIPAGERRPCGGGAPRL 
               
               
                 QRIRIRTGSDGRAPIWTEFHMLLHRPLPPGKILWVRAHQTRVGIRTMYNIQFVVDIDTAGRAPRARPAGGAVMDDR 
               
               
                 APQARSHHVGDATDDRAPQARSMMSHAIVGVDIGWRKLENGDWRVAMAVIPDGTTDELVVPHDVLRRADKSADLRS 
               
               
                 IRDQSRDAMRTRLLAFRETVVASLEDATPAPSADWLEATRTMHAWLKFGRFVRLRHWWAQHRFAGDEEIYSALCAW 
               
               
                 LDNDRHLIDWQEFNIRRMKRQIDGLYQAWAMRLARSFDVIAIEDMNLTDLKASSPGLVSDLAHERGMVVGLSHLIG 
               
               
                 WLKRATAGYNTRLVEVDPAYTTRNCRKCGFCRPASAELVIKCEACGFAEDQDITAGHNITARAVATLEEPTPEATP 
               
               
                 VKRRVRRTRRRPNEATTEPNNG (SEQ ID NO: 213) 
               
               
                   
               
               
                 &gt;3300020034 Ga0193753_10002988_9 
               
               
                 [terrestrial-soil] 
               
               
                 MIDRSEIDPGNRDAQLYQRGTTQLIDRLEIDPGANQGAIMKEIRVYKHWAEPASAVDHHRLQSQLKLAYQYRRMLA 
               
               
                 MIENAARVAQRALVQADPAIAMLINQLAVLHEADPPATIVITAAQEALRLARRDLHKTDAYKLEARAIGDRRQVLV 
               
               
                 RGARGLFSAQGLAWGTYQHVEEAHDQSCSENPYWEDVKVRLTPGFGAIAVHIQNRVLPSGTLVGGRDTFVQIDAER 
               
               
                 YGLSTFRNGWRAIDPDGPSGRVQIPAGERRPCGGGAPRLQRIRIRTGSDGRAPIWTEFHMLLHRPLPPGKILWVRA 
               
               
                 HQTRVGIRTMYNIQFVVDIDTAGRAPRARPAGGAVMDDRAPQARSHHVGDATDDRAPQARSMMSHAIVGVDIGWRK 
               
               
                 LENGDWRVAMAVIPDGTTDELVVPHDVLRRADKSADLRSIRDQSRDAMRTRLLAFRETVVASLEDATPAPSADWLE 
               
               
                 ATRTMHAWLKFGRFVRLRHWWAQHRFAGDEEIYSALCAWLDNDRHLIDWQEFNIRRMKRQIDGLYQAWAMRLARSF 
               
               
                 DVIAIEDMNLTDLKASSPGLVSDLAHERGMVVGLSHLIGWLKRATAGYNTRLVEVDPAYTTRNCRKCGFCRPASAE 
               
               
                 LVIKCEACGFAEDQDITAGHNITARAVATLEEPTPEATPVKRRVRRTRRRPNEATTEPNNG (SEQ ID NO: 
               
               
                 214) 
               
               
                   
               
               
                 &gt;3300020156|Ga0196970_1000866_40 
               
               
                 [terrestrial-soil] 
               
               
                 MAYGHTALPAINWVYGCKRPFEGEELIRSQLRQANRYRNVLVAIERRRRTNFEQLVLRLCPELQKLETQRNNLTQE 
               
               
                 IIELRAAMKAENARQRKTVRNPESTRRIKELQAQRQLLRPRIKELRDATYTHPTVKVVDENAAAWVKRARAACGIY 
               
               
                 WGTYLVREATVKQAIKDARPGLPEFKRFTGQGAVAFQSQQGTSTALLEAGGGNNLVQMHWNEPRNRRGRRRGELWF 
               
               
                 RIGSDANRRPIWAKASISQHRPFPPDTVIKFGHLHLTKCGTRESWSVRFQLVRESGFVRTGLAAAGRVGVDIGWRR 
               
               
                 VPGGLRVAYWVGDDGREGQELLPEDFLASKQYVEELRSRRSLEFDAVRQRLATWLQMTSNVPEWLLDRTHSLAQWK 
               
               
                 SVDRLCWLVKAWAEQRFSVDESIFPVLWRWRGQSLRLKEEESHGQRKLVVRRRQLYREIALRLAQEYRTICVEDFN 
               
               
                 LQKLLTKPQVEQDAVEAGVTYHSQLAAVGELRMFLAERAADVLRLPAQGTTQHCHMCGAKSNASDKSQLVHTCQSC 
               
               
                 SAQYDQDRNAALWLLRGGVPEYAIDGA (SEQ ID NO: 215) 
               
               
                   
               
               
                 &gt;3300020579|Ga0210407_10000200_14 
               
               
                 [terrestrial-soil] 
               
               
                 MTMIRVYKYGLLRPIQNEALVRAQLRAKHDYRNTLIEIERGRRTAMRNVEEQHSELATAMAASRAALVELEESRQA 
               
               
                 IRLARSKSRSRSETNVMKERVKQARIVRRTTSQALYDCRARVRPEMISARDVINERAAELVRGARALTTSYWGSYL 
               
               
                 LAEDEVKAAAKQPLYDDSTPNDPRFERWTGEGQIGMQIQNGMTPGEVLSSEDTRLRISEPNWNDGKHVRTLRTLSL 
               
               
                 RVGSEGRKPVWASWPLIMHRPLPPAARIKRCNVSLRRHSSREIWSAELTIECPNVTSAIREEHGWGRGGGVEGAVG 
               
               
                 VDIGWRVVTDDDAGLRVCAYASEDGQDIGELRLSPHEITRLRKADEIRSIRDKRFDAIRLIVRDKLATLEVPAWLS 
               
               
                 MSTLHMHVWRSPARLVSLSKRWSKERFANDEEVFDLLESWRYWDSQHYQWECDQRTKALRRRREKYRVFGARLAEK 
               
               
                 YEVLVLEDRAEDDRTKPMDLRKFARRAQTEMEPENETARSNRHLAATSELRQALEEAFISHGGRVELAPCEDTTRT 
               
               
                 CTACGVVDRGLDAETEIDVTCSSCGAKQDQDVRASNNLCERWRKAQNAGGARNAKAAKSEGRWKKARRLRTEKQQR 
               
               
                 MGTFRNASDNSAE (SEQ ID NO: 216) 
               
               
                   
               
               
                 &gt;3300_02_0580|Ga0210403_1000055_0_35 
               
               
                 [terrestrial-soil] 
               
               
                 MTMIRVYKYGLLRPIQNEALVRAQLRAKHDYRNTLIEIERGRRTAMRNVEEQHSELATAMAASRAALVELEESRQA 
               
               
                 IRLARSKSRSRSETNVMKERVKQARIVRRTTSQALYDCRARVRPEMISARDVINERAAELVRGARALTTSYWGSYL 
               
               
                 LAEDEVKAAAKQPLYDDSTPNDPRFERWTGEGQIGMQIQNGMTPGEVLSSEDTRLRISEPNWNDGKHVRTLRTLSL 
               
               
                 RVGSEGRKPVWASWPLIMHRPLPPAARIKRCNVSLRRHSSREIWSAELTIECPNVTSAIREEHGWGRGGGVEGAVG 
               
               
                 VDIGWRVVTDDDAGLRVCAYASEDGQDIGELRLSPHEITRLRKADEIRSIRDKRFDAIRLIVRDKLATLEVPAWLS 
               
               
                 MSTLHMHVWRSPARLVSLSKRWSKERFANDEEVFDLLESWRYWDSQHYQWECDQRTKALRRRREKYRVFGARLAEK 
               
               
                 YEVLVLEDRAEDDRTKPMDLRKFARRAQTEMEPENETARSNRHLAATSELRQALEEAFISHGGRVELAPCEDTTRT 
               
               
                 CTACGVVDRGLDAETEIDVTCSSCGAKQDQDVRASNNLCERWRKAQNAGGARNAKAAKSEGRWKKARRLRTEKQQR 
               
               
                 MGTFRNASDNSAE (SEQ ID NO: 216) 
               
               
                   
               
               
                 &gt;3300020580|Ga0210403_10001296_17 
               
               
                 [terrestrial-soil] 
               
               
                 MIRVYKYGLLPPTQNINLVRDQFRAAHEYRNLHVEIERGRRAAVRELFDTDEIRAASELLSRTNGAERLPIYKSLA 
               
               
                 ALRSKRLKESSTRVDEIEELAAGLRRGARALTRCYWGSYLTIEAASDQVRKMPLYGRDGITPNDPRFIYWSGESQI 
               
               
                 GVQLQGGLTIPVLHEARDTRLRLERVSLEPARGRHPASRCRMLWIRIGSEGRAPIWATFPLRYHRELPSNATIKWA 
               
               
                 RVSLRREGLREEWSCEITIDIPGAHPRTLDTSLTGAIAVSLEWTAAVNELLVARTLDCQTGEYDELRLPARMVTGL 
               
               
                 RKPDGIRSVRDKNLNELRPRLIAAFREPMAPWLAAMVARIPHWRSPDPFHALAMRWRREKCDDAREAYDILQTWEL 
               
               
                 RDAHLWDYEAGSRREALRERRELYRVWSAKLSRRYKTVVLSDADLSVEARTTKEVQTDRQTAAVYELRQSLRNAFA 
               
               
                 GEESMGPGSNVQELCDRWNGEQTTGNIRNGEKSNTFEEVKGGAWAKRKSKKSSAKSILDATR (SEQ ID NO: 
               
               
                 217) 
               
               
                   
               
               
                 &gt;3300020581|Ga0210399_10010852_9 
               
               
                 [terrestrial-soil] 
               
               
                 MSVLVYKYGLRPPIEQADRVMLEMRAAHRYRNTLVEIERGRRAAQRALLAEQPQLAPFELALTVAQAELTQAYLEI 
               
               
                 RAARQTTRRRSETEPMRVRLRETRAAVRDARGSLYLARAWLRADPALATARDRIDGVAEGLRKNARAYRGCEWGTG 
               
               
                 GLIEKADEQARQMPLYDGAEPNDPRFQRWTGEGRISVQLQGGLELAGLEADTQLRIGDGVRLPGQTKPSKHAERYR 
               
               
                 TLWMRVGSDERRKPIWAVFPLKLDRPLPTNAIVKLAVVSRRLDGPRVSWTVELTLDTTTCARRESCGHGIVGIDLG 
               
               
                 WRVFGDEIRVCAWDGDDGETSELRLHGRLLSGLSRADDLRAVRDKNFNAALAAYLAWTDRQGPLPAWMRPRGIHQW 
               
               
                 RAPGRLAGLCLRWSRSRFAGDAVGFDALDVWRRRDLHLWWYESGQRRGSLAARKDLYRRFAAWLARRHDTLVLEDF 
               
               
                 DLTRVSFKGQANAQANANRHRVATSELRLILIHAFKSRGGRVVMMNPYMSTHECPVCHAVTAFDAAAYVTYSCLGC 
               
               
                 GASWDQDESAAKILRERGSDVGDPQSARSENGPDSGGLAESRWAKAKRMKREKEAARNETGKGA (SEQ ID NO: 
               
               
                 218) 
               
               
                   
               
               
                 &gt;3300020583|Ga0210401_10033176_5 
               
               
                 [terrestrial-soil] 
               
               
                 MIRVYKYGLLPPTQNINLVRDQFRAAHEYRNLHVEIERGRRAAVRELFDTDEIRAASELLSRTNGAERLPIYKSLA 
               
               
                 ALRSKRLKESSTRVDEIEELAAGLRRGARALTRCYWGSYLTIEAASDQVRKMPLYGRDGITPNDPRFIYWSGESQI 
               
               
                 GVQLQGGLTIPVLHEARDTRLRLERVSLEPARGRHPASRCRMLWIRIGSEGRAPIWATFPLRYHRELPSNATIKWA 
               
               
                 RVSLRREGLREEWSCEITIDIPGAHPRTLDTSLTGAIAVSLEWTAAVNELLVARTLDCQTGEYDELRLPARMVTGL 
               
               
                 RKPDGIRSVRDKNLNELRPRLIAAFREPMAPWLAAMVARIPHWRSPDPFHALAMRWRREKCDDAREAYDILQTWEL 
               
               
                 RDAHLWDYEAGSRREALRERRELYRVWSAKLSRRYKTVVLSDADLSVEARTTKEVQTDRQTAAVYELRQSLRNAFA 
               
               
                 GEESMGPGSNVQELCDRWNGEQTTGNIRNGEKSNTFEEVKGGAWAKRKSKKSSAKSILDATR (SEQ ID NO: 
               
               
                 217) 
               
               
                   
               
               
                 &gt;3300005435|Ga0070714_100002341_12 
               
               
                 [terrestrial-soil-agricultural soil] 
               
               
                 MSLKVYRFGARMPLDRDLVVAQLRAAHDYRNELIQYERGRREAMRALYDTPEIRDAEALLKQATKSDRKAAKRALY 
               
               
                 TLRREVLEARRDEAQAINALHHELQLGARALTRCYWGSYLDVESAMQQARAAPLYDEDGLTPSNPRFLRWREPMQG 
               
               
                 QIGMQLQASRPLTTADAMRGADTRVRVERRDGPYATLWIRVGSEGRAPVWARVPIKMHREIPNAATWKWVRVSCEP 
               
               
                 RSLRDNPEYRETWSVEITVDDPAPRARDLDTSRDGAIALSWSWDVLANESIRVASYVDTFGRRGDIVCPASIAKGI 
               
               
                 RKPDGIRAVRDMVWNEEQKEIIHRIKRNANAPRWLVEAANTMHLWRSIARVHELARRCRIEGIAEGPAYEALHKFV 
               
               
                 ERDLHLYDYEKNARDEALRERREWYRLHACWIARTYRHALVSDHDLSREARWGDESDVRFTAAPDQLRGAIKNALG 
               
               
                 DDAIVAYWDHEPEWCERACAAYLVGGARGEMFAERKEKTSNAWAARKKKKTETMTARKEAANASE (SEQ ID 
               
               
                 NO: 219) 
               
               
                   
               
               
                 &gt;3300009095|Ga0079224_100000262_28 
               
               
                 [terrestrial-soil-agricultural soil] 
               
               
                 MKRKKSQDESINWKYGCKSPRGEGAEILRQQMREAHNYRNKLVELELLKRQEFYDLERELFPEYADLQEQEKQQAD 
               
               
                 KVEDLRKQWKKANARARTRTEQHLLKAQIAEEKQTLKDLRARMKEMKEQVRNSEELKERSKQIKKRHYQRLKDLRA 
               
               
                 ETPAFWGNVGFVDQAAQSMASGSPPKYYRWEGEGFIGVSFRTPITPEVLMSGRNTRAWLEPCKTANNKAGRVKKTT 
               
               
                 LHIAVESENRKLKMASLPIYFHRDFPDGCEITSVRVFCKKVGQREEWSAVFQLRSASFAKPDAAADGMAAIHFGWR 
               
               
                 RVDDGLRVASVVDEDGTEEVLILPESIIDSYAYVKDIQAIRDYLWNETIAILSAFLKQHSDSLPEPVKEASQNMHL 
               
               
                 WKGRGRLVHLINVWSDHRFPGDEEMFLKLTRKGTPANEYHDSGWLHRDKHLWDIEANVRDNAALRRKALYREFAAK 
               
               
                 MRRKYRHLITAKLDLKKIVSVKNPEEEDDAAMKHHSRVAAIHSLQAALSDSMRDGWIWPAAKQASTCHECGAKFQ 
               
               
                 DDSGDAYISCENCGSTFDREFNACKNLLFGPKQVNAAPALV (SEQ ID NO: 220) 
               
               
                   
               
               
                 &gt;3300009095|Ga0079224_100170797_3 
               
               
                 [terrestrial-soil-agricultural soil] 
               
               
                 MAKRQREGTEALVYAYGLLDDQPELYSDPNVAAEVQRQRDFWDLLVRLEQEHEERVYQYLDEHAPEYRAAFEALCE 
               
               
                 KRRELDRLIERKRRERAEAKQKVEDPELDSAIKNATRDWKLAQKEMWAALKKARREHKEALAALRAEFYARIPKCK 
               
               
                 DSPLFWANYNRVRQSFDATLKRVRKQGQTVRFSDPHRDDVCLTVQIQKVRGVVGCSFEDLLSGRVSQLKIAPIDEA 
               
               
                 AWYTTRANRRRLCRTEVTMQVDRAGNTVRALVAVDRPVPPEARIKSAQLVWRRVGERYVGKLCLTISMPAVERTNG 
               
               
                 STAACGIDVGWRRTDDGGLRVATIVDSSGNVDHLELPADWMSGMDQVKRLSQYLDDAALDIATLLLGRDDLHPAIA 
               
               
                 AAIKRWRPGLGAGHVNVAALRDAVRELGFTGLPAELCCGVRSWRDRKERCCWYHRHIHLSTWRDNLRRKLLLRRRE 
               
               
                 IYRLAALTLAERYAVIGIEKLDLAKMAMTKKREDGSDPTLHSAARAQRQRACLHEFRTELEHQARKRGARLELVDA 
               
               
                 SKTTITCHECGAETQPTRRDRMMIHMACDSCGAVWDQDVNAARNILLAAIGASGDMTPPDDDGGSGAYKRHSEEIS 
               
               
                 DRSQLGAPLL (SEQ ID NO: 221) 
               
               
                   
               
               
                 &gt;3300010343|Ga0074044_10013672_1 
               
               
                 [terrestrial-soil-bog forest soil] 
               
               
                 MNILVYRYGLRAPHENRDLALSELRSSHEYRNKLIEIECARRKRVRAAEDALLGKPRLKLAEAQSALDAAIKAVSK 
               
               
                 HRAETRKRTTPAEMLATLKAAREAQHAASKAFRSARQLVQPRCSDCRKKDLPTPCEHATPEGVGLLAELDAAQDEA 
               
               
                 KESIKKFRNESGPFWGSYLLVDKAAGQSFSELALYDIDGKPNDPSFLRWTGEGTLGVQLQGGLSVEAALAGQDTQL 
               
               
                 RISSPPVACWDPSTGSRKARSRQSRESEVWLRQGSVGRAPIWCKFGLHMQRPLPPGAQIMWAEAHCRRVGPHFDWY 
               
               
                 LTLTLKVDDAVALKPRIIPTRDAVAIDVGWRVFGEGETHELRVAYWSDGSNDAPVVIREKDIRVPGFVIPPRGELR 
               
               
                 LDTATLNQLTQPEGVRSERDVLFDGVRARLIEWLKTPHENEPEWVDSDGVVVTLREHCKALHAWRSQAKMAALTSR 
               
               
                 WGEWLKEHPDGDKWAYDMLVAWRGQDRYLWAVESRWRDRARLRRRELYRLFGVALARTYGTVVLEEFDKREIAKRP 
               
               
                 KTEDDGEAHPARSNRQLAAVSELCECVAEAGTSRGRNVVEVPCENSTRECPVCGCVDERNAARKVTISCACGHVWD 
               
               
                 QDDGAADTLLGRWRKRPGDAKMAGAPRKPKILNGDGSVENRMQRAKRKGAEKALRKMELSKTTT (SEQ ID NO: 
               
               
                 222) 
               
               
                   
               
               
                 &gt;3300010343|Ga0074044_10041345_4 
               
               
                 [terrestrial-soil-bog forest soil] 
               
               
                 MTTRVYQFGLRPPIEGIDLVRAQLRAAHHYRNELIAIERGRRSALRQMDDTEEVRKAAGAIGGTAKADRRKAIANL 
               
               
                 RDARRRARESKPEEFKRIAEREHEMLLSARANTSCFWGSYLDIESAHRQARSAPLYGDDALEPSDPRFIRWTGVEP 
               
               
                 PSGTYPRLPQSGEGQIGMQIQKKGKSSENGKSSENGKPSEEKRRLVTSDVFACLDTRVRLKRGGAKDGDPRYGFLS 
               
               
                 LRVGSEGRAPLWATWPIKISREIPDAAEWKWVRVSLRHEGRRERWSCEITVNDPAPAARSLDSRLRGVIAVEWEWS 
               
               
                 KLEDDSIRVARWADSMGETGMVELPGSIAKGIRKPDGIRAVRDMISHELRPRLARLIREAKGPKPPWLVAAANTLH 
               
               
                 LWKSPRRAYELAERWTDPTLLPTARVVLFEWRARDEHLWDYEAGARSEALRERREFYRLLAARWARRYQSIILSDQ 
               
               
                 DLSREARWGEESDLRFTASCCELRGALRNAFGPDAFDGKYARSEQEDWQWCEQARDAWMAGGARKDAMCAKRKEQT 
               
               
                 GNAWAKRKAAAAAKRAEKGSACEPPGKSV (SEQ ID NO: 223) 
               
               
                   
               
               
                 &gt;3300005468|Ga0070707_100000083_12 
               
               
                 [terrestrial-soil-corn, switchgrass and miscanthus rhizosphere] 
               
               
                 MPVIVYEYGLSPPKVNAAIVEEQFRLAHKYRNMLTEIELERRTKIRAIMASHPDMVPFETELAEVQAEIEKLRGEI 
               
               
                 NAIRMAARKRSSTPEQSKRIKTLAARARELRTEIKERRKRVATELAPDLKAIQDAAVQRRKDERAKSGVYWGTYLL 
               
               
                 QEAAADQARDQPMPPKFTRWNGDGRVSVQIQQGLAKEGLWGESRQVQIATRIDSLVYDHEVTRRGDRRRLYRTTLR 
               
               
                 MRVGSTDRQPVWAEWGISMHRPIPDGAVIKVVTVSRRRCNSTQWWWRVQFTLDTTDCKPRQRPEYGVVACNLGFSQ 
               
               
                 TDSGAIRAGYLVGDDGFEQEILVAKSDLYRGRDLTPEQKQKAMTYVRDCLAESSEIRGARDKSLADFKTRFLEWYQ 
               
               
                 IAKATTFGEDAVPEWFRDRMEHFHLWRSPARVREMMLHWASNRWAELDDPESRWPDSRGLEMMSTWVDEDTKAEVK 
               
               
                 ESSLRNKALGDRREAYRIVAATLAKRYKTLLIDDTNLKHLQDGPEPEDAEGDIPAVKYQQRLAAGSELRQVLINAF 
               
               
                 GGTNVVKMKPSNMTVTCSGCGARDVSWDRADGFRKHRCSACREIWDQDANFCRNLLKEYASGGEAPAAKIAKPSRS 
               
               
                 QRFHESRKKKAAAADQQEQG (SEQ ID NO: 224) 
               
               
                   
               
               
                 &gt;3300006163|Ga0070715_10000067_44 
               
               
                 [terrestrial-soil-corn, switchgrass and miscanthus rhizosphere] 
               
               
                 MPKKPNPNKRVSSDTRGARIWSYGVLFPREREVNDAIRSLLHQANRYQNCQVVIERVRRQRYRVIRSAASPELARL 
               
               
                 EQEYKDLGLAIDAEVDTMRAQRASVRRRTTDPVIAAKIKALKAKRAAVNIELKIAREKANAILRPIQDAYNRHRKP 
               
               
                 GGVKAAPRTAEKLNAAARQTTLEEDWPELAKQLLRLEDWATRRVKQAREASGLPPGTYLLVDQAIAATKKEPTDPR 
               
               
                 PKRFDGTGRIGVQLFDFTPQTLFSRERKQLQIDPLPATQWDTRPGRRKARTELRIDFGGNAFEMKAAFKMILHRPL 
               
               
                 PQDASIKWAWIHVTRIGSRLHYSLQLTMRSDTFQLKPGGQGVVAVNLGWRIKEDGAMRVAYVMDEFGTERELAMPP 
               
               
                 ELRGGFVLAENLRSYSDQHFNVAKKAIGEFVKTDAAPAWLKEQCTSMHAWQRHGRLLRIARMLAIAEFPDTVLPSG 
               
               
                 ERVRNGMLSELWKRWKEHRLAAVPKLDLFDTYQVITDWARARGATDLKAATLYLWVWKKKNDHLYNWECGLRAHKQ 
               
               
                 KCRKQLYRAWATELATTYSTILVEKFDLRDTREKSAPEAEQEENPTSLIRSQNFAAPSELRDAIVAAAGTGRVKEQ 
               
               
                 KSHNNTVTCHECGHTSDRDRRFEALIQVCESCGVVKDQDKNNCENQLSRYFSGESPGGGLDPESARNHENSSDLKT 
               
               
                 DRDAAE (SEQ ID NO: 225) 
               
               
                   
               
               
                 &gt;3300014498|Ga0182019_10003703_1 
               
               
                 [terrestrial-soil-fen] 
               
               
                 MKRKTSPIPTKVYKYGLLAPVENVKLVDHAFYLGGKFYNKLIEIERTSRNEYRQERARRFPNHDKVEKLVATLSDQ 
               
               
                 KKKLSEIIKASKIATKSRNVPPELATEYKTLAAAYKSAKLRQDAEREQCKKDRDFSAWTLTHNEKKNALVADARKN 
               
               
                 SGLMWGTYNAIAASVQQAGASAILDPEFKSYRGEGRIVVQIQGGIYLAELGSDTQLQINLPNLNESLTRGEWRQSS 
               
               
                 RTIVKMRIGSDKHKKPIWATFPAVFHRPLPSDARIMSATITRRRLGVFQSSGRYEYHLCISCESTMFDNEAVRPRL 
               
               
                 QDPTQQREVREHRGTSTINFGWRQFDQGKDKRLRIAMTNNEVTGLEPLWLPREIILGLQKCENLRSIIDMKFNEVR 
               
               
                 ALLTTWLTPHKQDCPAWLAESLQFLHTWKQPDKLDRVVANWGSGMRFPADADIYPVLAEWRTKHRHLSEWMMRQRR 
               
               
                 KSYNHRDDYYLKTAARLAQSSSRMVIENFTISKVAVKPGPEVEKTGGNEARHNRTLAAVSELRSALIHACSKHHCP 
               
               
                 MDITPAVNNTRRCNVCGKLLDWDPAIKVDRQCPECSNWDQDVNATDNTNDKVASGDVVTMVVPAKTSENGEFEAGT 
               
               
                 ISTFGSARKRLHNLEKTLTIQE (SEQ ID NO: 226) 
               
               
                   
               
               
                 &gt;3300001131|JGI12631J13338_1000296_13 
               
               
                 [terrestrial-soil-forest soil] 
               
               
                 MPVTALPDGTISTARYAARGPVPAPVTEELRLGNWLDNLLTEYELDYEAAKAAAWEEDPHVALLLAAVTAAEQAWQ 
               
               
                 AARDESAACKQKLGYAKRTGTPARIAAAKAAAAQAQQAYRAAVKARQEAAAALRDIKGLRWHVAKAAINAAAEERD 
               
               
                 RKIAATYGPYRDRGGYWANWAEHAKHHKTAAKRVRDMRKQGQPAQLRYHRFDGTGTVVVQIQRELGVTPEIRAQVT 
               
               
                 ALKAAGRTPGQIKAETGVRAMTAAKMKPEGAVKEGDPPCTAAALADETGKWRSSVRLTPELPAGFEELPRGERRRI 
               
               
                 ASQGMFAIRTGSAANLAVSVVPVTVHRRMRGDGDVKYAKLTVTRNGPDKDMSVSLTQRVPAPQPRAGGRLVCVHAG 
               
               
                 WRALPDGSLRVAVISGAGPLTPGLAAPGGRDARAGELTGVVRDLGDGCHEVVIPARWRDQDAATAKTRSVRDLARD 
               
               
                 TAI7W\ADWLAASPRYETTDGEPLPAAHEVRRWQSPGRLAVLGQRAARGDYGDDAAGLGELIAGWAVPDLEAWRRE 
               
               
                 ARGRRHLTRRRDDAWANVAAWLCTGTREVRVDEWDIRAVTRRPGPGETDDPQAAAARANRTLAAPGALRQRLTITA 
               
               
                 VLAGVTVTVLDPPDAGSVLQVHAGCGGVLDRDARRESIVVQCPGCGARVDQDVNMVRLMAARQPSA (SEQ ID 
               
               
                 NO: 227) 
               
               
                   
               
               
                 &gt;3300001593|JGI12635J15846_10002852_1 
               
               
                 [terrestrial-soil-forest soil] 
               
               
                 MPVTALPDGTISTARYAARGPVPAPVTEELRLGNWLDNLLTEYELDYEAAKAAAWEEDPHVALLLAAVTAAEQAWQ 
               
               
                 AARDESAACKQKLGYAKRTGTPARIAAAKAAAAQAQQAYRAAVKARQEAAAALRDIKGLRWHVAKAAINAAAEERD 
               
               
                 RKIAATYGPYRDRGGYWANWAEHAKHHKTAAKRVRDMRKQGQPAQLRYHRFDGTGTVVVQIQRELGVTPEIRAQVT 
               
               
                 ALKAAGRTPGQIKAETGVRAMTAAKMKPEGAVKEGDPPCTAAALADETGKWRSSVRLTPELPAGFEELPRGERRRI 
               
               
                 ASQGMFAIRTGSAANLAVSVVPVTVHRRMRGDGDVKYAKLTVTRNGPDKDMSVSLTQRVPAPQPRAGGRLVCVHAG 
               
               
                 WRALPDGSLRVAVISGAGPLTPGLAAPGGRDARAGELTGVVRDLGDGCHEVVIPARWRDQDAATAKTRSVRDLARD 
               
               
                 TAIAAAADWLAASPRYETTDGEPLPAAHEVRRWQSPGRLAVLGQRAARGDYGDDAAGLGELIAGWAVPDLEAWRRE 
               
               
                 ARGRRHLTRRRDDAWANVAAWLCTGTREVRVDEWDIRAVTRRPGPGETDDPQAAAARANRTLAAPGALRQRLTITA 
               
               
                 VLAGVTVTVLDPPDAGSVLQVHAGCGGVLDRDARRESIVVQCPGCGARVDQDVNMVRLMAARQPSA (SEQ ID 
               
               
                 NO: 227) 
               
               
                   
               
               
                 &gt;3300009813|Ga0105057_1000075_5 
               
               
                 [terrestrial-soil-groundwater sand] 
               
               
                 MEDAMEADQTPATAEPAAGAVIVYRCGLRAPLDWGRDCDDQLYLMTRLLWNTLVEIEHAHREAYFAATASDPWAAI 
               
               
                 EAEITGLERLLEQLYAQRAELRKAARKRVRTPELDERIAELKAKLKARRAEAKEARKAARETIKPQLETLEAERRE 
               
               
                 AVKVARNASGLWWGNYNAVCADYDRARSAVIKRGGKLQFRRHDGSGRLVNQIQGGMSVADLLGRAHSQVQVTGGAW 
               
               
                 AVNARGHLTATVYTRTAAAARAAGAGGTRRTVTWPLQLRRPRPGPYAQARIKEVVITRRRRGHKFDWHVSFLCQLP 
               
               
                 ATEPALPAGRACGIDVGWRRLNDGVRVGTIVYSSGEREFVVLPERLVAAARRAQDIASRRDKIFNDLIVSWRAIDW 
               
               
                 TNAPEELAATAVRLQKSKLSPPQLHGLVYAWRRHPFFAPDAFTVADRWLAEDKKLWETEASLARHVSNARRDLYRG 
               
               
                 AAKRLVATCGLIGIEDIDLAALARRKTPAGGDNEIAQATAWWRRIAAPGELLAAISHAARRDGALIHKHSGKSTWI 
               
               
                 CAQCGTESMPSDRSQLVHTCPHCSHTWDQDVNAARNLLAAALASAPVTLDGPAALAWEKPRDPNDLEE (SEQ ID 
               
               
                 NO: 228) 
               
               
                   
               
               
                 &gt;3300009813|Ga0105057_1000075_5 
               
               
                 [terrestrial-soil-groundwater sand] 
               
               
                 MEDRMEDAMEADQTPATAEPAAGAVIVYRCGLRAPLDWGRDCDDQLYLMTRLWNTLVEIEHAHREAYFAATASDPV 
               
               
                 VAAIEAEITGLERLLEQLYAQRAELRKAARKRVRTPELDERIAELKAKLKARRAEAKEARKAARETIKPQLETLEA 
               
               
                 ERREAVKVARNASGLWWGNYNAVCADYDRARSAVIKRGGKLQFRRHDGSGRLVNQIQGGMSVADLLGRAHSQVQVT 
               
               
                 GGAWAVNARGHLTATVYTRTAAAARAAGAGGTRRTVTWPLQLRRPRPGPYAQARIKEVVITRRRRGHKFDWHVSFL 
               
               
                 CQLPATEPALPAGRACGIDVGWRRLNDGVRVGTIVYSSGEREFVVLPERLVAAARRAQDIASRRDKIFNDLIVSWR 
               
               
                 AIDWTNAPEELAATAVRLQKSKLSPPQLHGLVYAWRRHPFFAPDAFTVADRWLAEDKKLWETEASLARHVSNARRD 
               
               
                 LYRGAAKRLVATCGLIGIEDIDLAALARRKTPAGGDNEIAQATAWWRRIAAPGELLAAISHAARRDGALIHKHSGK 
               
               
                 STWICAQCGTESMPSDRSQLVHTCPHCSHTWDQDVNAARNLLAAALASAPVTLDGPAALAWEKPRDPNDLEE 
               
               
                 (SEQ ID NO: 229) 
               
               
                   
               
               
                 &gt;3300014489|Ga0182018_10031574_1 
               
               
                 [terrestrial-soil-paisa] 
               
               
                 MIRVYQFALRTPVDNEPLARAQLLAAHRYRNQHVAIERGRRWAVRLCEASEEVDEAVALVQSATKSTRKDALKDLR 
               
               
                 AARKAARETHADELARIAELDAEIRRNARSHTSSYWGSYLTIEQSSDQVRRMPIYEPDGLTPSDPRFVRWTGAGQI 
               
               
                 GVQLQGGALTPDVLAGRDTRIRLIDGVLWLRVGSEGRDPIWAKWPIVQHREIPSGADWKWARVSLRKEGPWERWSC 
               
               
                 EITLEIPGEHPRNLDKDPQGAIAVEVTWDKPGDALVVARWRDDAGRTGTIELSEYDEQGIRKPDGIRSVRDQLLND 
               
               
                 LKKRLPRAYAECRGDLGPPWLGEAIDGAQYWRSQSRAHTLLTRWRAEKCDAARAAYEILDAWWLRDMHLWEYEAGA 
               
               
                 RGQALRRRREKYRVLAVTWSREYRHVILDDRVLSREARFGDASDLRFTAGPSELRQCLEHAFGGRNGGNVTTHPVR 
               
               
                 DDAAKSETEERDWCERAIDAWIAGGARATKKVSESTGVKGGAWSLRKSKKSQKQAENGTAREPVAKGAV (SEQ 
               
               
                 ID NO: 230) 
               
               
                   
               
               
                 &gt;3300014501|Ga0182024_10047267_8 
               
               
                 [terrestrial-soil-paisa] 
               
               
                 MSKFRVYQYGLKAPTENAELVREQMFLAHRYHNTLIEIERGRRGAIRTLTRGHNATIRQLEADLLEADALVGKIVR 
               
               
                 EIKTQHSETRSRLSTQTDKEELKVARQKKKEIKSQLIEARYLDKNNPSIINERTNINDLAKEAIKSARKHCGVYWG 
               
               
                 TSQLIDDAVEASRKMPLYNGEKDNDPSFKPWKHQGSVGVQIQKRDDIQGMDVKNVFGADTCFRIDCVNEGAFYAEK 
               
               
                 RGDRRKQRKTTMRMRINSDDKGKPIWSYFPMTMHRPLPDGGIIKKAKVRLKKIGSREEWSLSITVDMSNVLMTTNN 
               
               
                 NHEAVAIDIGWRDMKDDNGQTTGFRMCKSRGTDGKIEEIKLDPKIISAIKKANELRGLRDDNFNKERASFVAWAKV 
               
               
                 NVLPDWLVKETKTIAQWRSISRLVKLFKQWKNNRFDGDEVIFGVSGKWNKGDKSVITGTGLAGWAYHDFHLWNWEA 
               
               
                 NQRTKAIRRRKEFYRVEASKLAKQYQTLVLEDFDLSDVSQTAEPEAEDDNQRGRSNKTISSPSEFKLALINAFDAR 
               
               
                 NGKIEKVNPKGTSYICHLCKSKEHLDSTFHIHTCSKCHQTWDREDNATANILTLWRERLSDEQNAVSARKDENGNE 
               
               
                 NKGVEETRYQRRNRAKQEKKARLETARNAEANIAE (SEQ ID NO: 231) 
               
               
                   
               
               
                 &gt;3300014501|Ga0182024_10150440_2 
               
               
                 [terrestrial-soil-paisa] 
               
               
                 MIKTEKYGLLSPTLNADLVLLEMRKAHDYQNNLIEIERWRRDEIRKIESIYGNIPQLTIDYDIASNDYETILKTKK 
               
               
                 KNNSNARANVSTPELNQQLKDAKSKRKACENKLKQARLSSRKDDKIKKAKDNISILENKKQSLLRKSDAAPWYGTY 
               
               
                 MLIDHAFGIPSAKGKTKGMPLYNGINPNNPIFRNYNGEGRIGIKQFQPYEPINKIININPTSKFLQIVPIPPPKLK 
               
               
                 KDGSQRKIGNKNLKLLRIRIGTGEKNAPIWAEFPMVYHRPLPSNSVINMVQITKKIIASREKWAVSISYEDNIQFS 
               
               
                 KNEIKKVVAFDLGWREFPDRIRIACWKDNDGKSGEISLPIGLGIKKDSNDKIIKNKDGNDKLFHSTINKLRKVKEL 
               
               
                 KSGRDLDFDRVKQLFGYFVNSGIIFPQWFQDWLNTTNKNGKKINDITYISKWRSQTKLSKLILQWKNNRFTGDEDI 
               
               
                 YMWLEYWRYHDFHLRDYEYNLRNKSIGAIESLYKNTAAHYANNYDAAIFEDINLSNIAKGKVGSTNRQLTAPSKFR 
               
               
                 NACKNAFNMRGKCYEEIIARNTSRECAVCHVLNDIGGKLEYFCSGCNVELDRDENAAENILERGRKKLSDNNTYID 
               
               
                 SHENCEHDSNAKNAVGARIDENCNENNNLQYA (SEQ ID NO: 232) 
               
               
                   
               
               
                 &gt;3300001356|JGI12269J14319_10001968_12 
               
               
                 [terrestrial-soil-peatlands soil] 
               
               
                 MTRRVYQFPLRAPIEGAALVRAQLRAAHEYRNDLVSIERGRRSALRAVDDVPAVREAIAVVLAATKSTRRSAIALL 
               
               
                 RDARKEARAKAADELVRIGVLDAQARRDARAITPTWWGTYLDIEAAHNQARSAPLYEPDAVTPSDPAFARGPRLGR 
               
               
                 EAFAPDDARAAWWLGDGQIGVQLQKGLPTPGALAGADTRVRLVLRPADHPRDRYGTLWLRVGSEGRDPVWAQWPIK 
               
               
                 LHRAIPDSAIWKWVRVSVAREGTRERWSVEITVDDAAPRPRDLDRSLAGAIAVEWEWSLLDSGAIRVARWADTRGG 
               
               
                 SGELLLPERIATGIRKPDGIRAVRDLELNALKDSLQQALREASDVATPRPPWLADAASTLHLWRSPDRFRGLLYRW 
               
               
                 QRERYDGARSAYEMLEAACHRDDHLYDYEVGARRGALGARRDLYRCVAARWSQSYRTVLMSDQDLSREARWGPESE 
               
               
                 VRFTAGCFELRSCLRNAFGDADAIDSRWRDAPGEQEDREWCERTRDAWSAGGARGDGRFAIRKEKTTNAWAARKAK 
               
               
                 SKAKRGGDEASRDPDGKGAE (SEQ ID NO: 233) 
               
               
                   
               
               
                 &gt;3300007533|Ga0102944_1012316_2 
               
               
                 [terrestrial-soil-pond soil] 
               
               
                 MAGRKKKDAPPSRVWIFGCGEPVDGAELVRDQLFETHRYRNDLARHVLNSRQVYREARSEICRVAALEQEHLEAKE 
               
               
                 ALDVLRQEQKAWSAAARRRVQSPELQQAIKDAKQKKRDVLERLKQAREEVEQDPELQQARAEINKRAAAEKKRLYN 
               
               
                 ESPAVWGSRLRVDESWLQMRWGRMDPKFRRFDGSGRVVVQIQKGMSVAQAFECKDTRFQLARPTRDWDRRTGRRGG 
               
               
                 TRTMFRIRVGSEGKRRTPVWATFPVTLHRELPEDAQIKWVEVRAVRQGPDLRFQLHLTLEWHGFDPRSRGAGAVSI 
               
               
                 VCGWRAMHDGTVCVGRWIDDSGRSDVLVLPADVGEAEKHASSLRSISDLHFDAARRVFKSRRHLLPAWVTEESAYL 
               
               
                 DKWRSHARLAKIVGRLTAEILGDEAAHVWRQWRRYRQREGLDLHAPYEELSTWLSEQGEVDPARQTAFYLEWWRRK 
               
               
                 NRHLHRVECNVRTKALRRRKAIYRNWAASFARRYETVLVDDFDLRQFARNAAPEEDARQDYLHGVMRLAAPGELRL 
               
               
                 AFLHSLGGARAVKVPATEGLRRCYLCGSPMRRPDRSGTVEHDCGVITPWQTIRGLDMLRGAGVDTVAAEQKLLEGH 
               
               
                 EAMKKLFRELARKG (SEQ ID NO: 234) 
               
               
                   
               
               
                 &gt;3300005903|Ga0075279_10000001_30 
               
               
                 [terrestrial-soil-rice paddy soil] 
               
               
                 MSETDTMAFKFRILRIVSDEARIKREIREAHQLYNDLVAIERKRRDDTRLFWADRGGYADKLAGLRAAAEDAEKAA 
               
               
                 ALTAKGDAGKKERQEIWAPVDTLKREIWELQRKTEEELSDPAKVRRKQRARELQAEAKARAGKALKKEALAALLDA 
               
               
                 EPDCMSPRDRRRLELVREYEARGVAVSGKAVAQRLRDEGLVGPTEQIEEAARKAGYEAYLKRGVSPGTRAIIADAF 
               
               
                 ERSLEDLEPWATQRFSRWDGHGSFGVQVQGGSLTEEVYSGEHTQVRLRRLEDTGKHREGSRRSGRRHELRVRIGSD 
               
               
                 GRAPVWAVFEAIVDRPLPPEASIKRVVVTCDRLGVLDIYHVVFTCSVPSSVYHKRSGEQRGTVAVDFGWRSLGGEE 
               
               
                 MRVGYWVNDRGESGEIRLPGVGVARRGTTGKNSPYEPKIRGQVPIRQLDKHTRDLTEIMAREFAEYDGGKICGGAL 
               
               
                 RDVASWLSANVSIVPEWLTERTTGIHVWRSQHRLYWLAQDWKAQRFDGDAEIFERLSAWASDWAHLAEWERRQHAA 
               
               
                 ILAARNEHYRLVAVGLAKKYERIVINGADFAAAKRRKTKDETDRLVMIDDRSRSQAHLAAAGELREEIVRSAKKWQ 
               
               
                 AIVMKAKPNKATCHACGSTCVYDAAKDLAHECEHCGVRWDQDENCCRNMLCEWSGDGQTAGGARVSPNAKKSGEVL 
               
               
                 RSKKRDEDGGPIGEAAE (SEQ ID NO: 235) 
               
               
                   
               
               
                 &gt;3300005524|Ga0070737_10002282_10 
               
               
                 [terrestrial-soil-surface soil] 
               
               
                 MSTGTVPPAAGNTPPTGEVTVARRYGAKPGPIPAAIREELDRAHWLVNRLVEIDRECDEQVTAVWEADPQVGPVLA 
               
               
                 AVRDAEDARAAASEELRRAKVKLGAVKSGRSRTGLDVARARVDAAREAVRQASAALKQARDRAGAVKQERWPAAAP 
               
               
                 VIRAAQEARDAAIRATYPEFVARGGYWATWNDITGAHKRRRDRVQQLRRQRRPAQMRYKRRDGTGTLTVQLQRQLG 
               
               
                 VSAAERAHVTGLRDAGLAPSQIAALITAGVPAAEVTPARVARLRAAGLSAPEVTQALVAGADPAAAAAASRTPGKA 
               
               
                 ARRAALGEVLAAAAAARPPRTPGRRWRPQSVARVRAGGKDTPGDPPFTPDVLAGPAGPAALQVRPVLPPGYPQLPR 
               
               
                 RQQRALARQGEVVFRTGSAANAAYTTIPVVLHRPLPAGGDVKMGRLTVTRCGPDLEQSVSITARVPAPPPAAGHTA 
               
               
                 AVHIGWRALGDGAIRVAVITGPRTPPPRQLAEAGVVRPVGGCWEVVVPPRWQVALTRVDGMRSARDREWQQVRDRV 
               
               
                 AAAIPPGHDTLPPPAQVRAWRSPGRMVTLAAACEAGEHGGHGRAIADLVTPWARRDRAAWRNESRARRRILRRRDD 
               
               
                 AWAVIAAWLTAGAGTVIVDDWELPPLGRRPGLTEEDDPQWRAARANRVLAAPGALRARVRVTAELAGVAVAEFPVP 
               
               
                 RPGQAHAGCGHPLDPDARREDVLVPCLGCGVKVDQDINMLTLMLDGAREGAPQAG (SEQ ID NO: 236) 
               
               
                   
               
               
                 &gt;3300005524|Ga0070737_10031205_1 
               
               
                 [terrestrial-soil-surface soil] 
               
               
                 MTAYSYGCPAWAVPLAPRETDPVTVIAALAGTAQALRQAQAALPGGGEREWKRWAQALQARDQAREAVWVTGEEAL 
               
               
                 AGQLRLACRLWNRLVEVTRGHERARAAVWASDPAVAAAQETLDAARAAVAACHERIRVSRQADRTTVPRDADKQAL 
               
               
                 DEARAAARAAREARDAAREAAFPRLRARFAAAAQARLAGVKZAAAEATEAGLGWAACNDITWRRFPAALQKVDRER 
               
               
                 AAGRPAELRFRRWDGTGTVTVQVMGGAGIPPRTLPALNSGRHPRSAVMRLQPWRDPSAGRPKGADRHGTLTLTAGR 
               
               
                 SRRHGPLRLQIPVVLDRYLPADADIAEVKVTRFREGTRHRLRVSAACYVPAPPGPPPGGATVAVRLSWRAAGGGWV 
               
               
                 TAAQVGSSSPLPPLPRSLEHAVRGTAGGPRLPLVRVAPGSLSAEVLYYAGWRRLLERGEAIQAVRGQNTDILREKV 
               
               
                 TAALRDDPALAAAVKVTAGEVARWRAPRRFAALARRWPAGHPLRPLLEEWRRRDRHLQDYQACETAQVLAARRDAW 
               
               
                 RCTAAWLCAGASAWIDGTRLDAEKQAPGDDEEDPEGARGARRLLHRSAPGELRAAVEAAAARRGIPVTILKAAVE 
               
               
                 PAAGGGA (SEQ ID NO: 23_7) 
               
               
                   
               
               
                 &gt;3300005524|Ga0070737_10031205_1 
               
               
                 [terrestrial-soil-surface soil] 
               
               
                 MTAPGGEGTPARVMTAYSYGCPAWAVPLAPRETDPVTVIAALAGTAQALRQAQAALPGGGEREWKRWAQALQARDQ 
               
               
                 AREAVWVTGEEALAGQLRLACRLWNRLVEVTRGHERARAAVWASDPAVAAAQETLDAARAAVAACHERIRVSRQAD 
               
               
                 RTTVPRDADKQALDEARAAARAAREARDAAREAAFPRLRARFAAAAQARLAGVKAAAAEATEAGLGWAACNDITWR 
               
               
                 RFPAALQKVDRERAAGRPAELRFRRWDGTGTVTVQVMGGAGIPPRTLPALNSGRHPRSAVMRLQPWRDPSAGRPKG 
               
               
                 ADRHGTLTLTAGRSRRHGPLRLQIPVVLDRYLPADADIAEVKVTRFREGTRHRLRVSAACYVPAPPGPPPGGATVA 
               
               
                 VRLSWRAAGGGWVTAAQVGSSSPLPPLPRSLEHAVRGTAGGPRLPLVRVAPGSLSAEVLYYAGWRRLLERGEAIQA 
               
               
                 VRGQNTDILREKVTAALRDDPALAAAVKVTAGEVARWRAPRRFAALARRWPAGHPLRPLLEEWRRRDRHLQDYQAC 
               
               
                 ETAQVLAARRDAWRCTAAWLCAGASAVVIDGTRLDAEKQAPGDDEEDPEGARGARRLLHRSAPGELRAAVEAAAAR 
               
               
                 RGIPVTILKAAVEPAAGGGA (SEQ ID NO: 238) 
               
               
                   
               
               
                 &gt;3300005534 Ga0070735_100239675 
               
               
                 [terrestrial-soil-surface soil] 
               
               
                 MEKRESTVVTIAPVRMCGTTIRVYRYGLAPPLDWDDECDAEMARLDRFYNALVEIEEAAQAEYRRLSSSDETALLE 
               
               
                 TRIAAAEEAKDWGAAKALRAALKEIRAALRKANAAAIDAAEEKRKADAKAARQNCGAYWSSYNAVIRSVELARQKA 
               
               
                 IKEGAAFGKRTHEPGKGDWRMTVQIQGGASVADVLGGKNSQLRIAAPAHFGALRDRPAGMSRKACRHGRVTMVVHN 
               
               
                 TGGLRRVTWPLMMHRPIPPEAIIVGAEIVKRRRLGSRWDDWHLCVTVREPAPAPHESPDCAGVNIGWRRLSVERGL 
               
               
                 VIDGAGLRIATIWDGATLNHVILPEEIISAAWRCDELTSAIDKRVDAATARIFKDSPDHPVARQLGDTFVESGRLR 
               
               
                 VRDLWTFANAMTPAPDWLLAMLRACSRDRRERAGLLRRMARRRRDIYRVAAKTIAENYGRIAICAVDWAKLARLRE 
               
               
                 SGKDNPLPPPARGYRKIAAPGEFEAELRRAIKARGGTIMDIKDSVSFLCHACGKEHAPSERSAAHHTCPSCGATWD 
               
               
                 QDRNAAMNLFAALDSSGPAAIKPADSLENGKGEMQSTAYVGRFQRRAKQAQEAKLANKEALENASELVDETIGCK 
               
               
                 (SEQ ID NO: 239) 
               
               
                   
               
               
                 &gt;3300005542|Ga0070732_10013271_3 
               
               
                 [terrestrial-soil-surface soil] 
               
               
                 MIRVYKYGLLPPTQNINLVRDQFRAAHEYRNLHVEIERGRRAAVRELFDTEEIRIASELLSRSSGTERLPIYKSLA 
               
               
                 ALRSKRLKESSVRVDEIEELAAGLRRGARALTRCYWGSYLTIEAASDQVRKMPLYGRDGITPNDPRFIYWSGESQI 
               
               
                 GVQLQGGLTIPVLHGARDTRLRLERVSLEPARGRHPASRCRMLWIRIGSEGRSPIWATFPLRYHRELPTNATIKWA 
               
               
                 RVSLRREGLREEWSCEITIDIPGAHPRTLDTSLTGAIAVSLEWTAAVNELLVARTLDCQTGEYDELRLPARMVTGL 
               
               
                 RKPDGIRSVRDKNLNELRPRLIAAFKEPMAPWLAAMVARISHWRSPDPFHALAMRWRREKCDDAREAYDVLQTWEL 
               
               
                 RDAHLWDYEAGSRREALRERRELYRVWSAKLSRRYKTVVLSDADLSVEARTTKEVQTDRQTAAVYELRQSLRNAFA 
               
               
                 GEESMGPGSNVQELCDRWNGEQTAGNIRNGEKSNTFEEAKGGAWAKRKAKKSSAKSILDATRQG (SEQ ID NO: 
               
               
                 240) 
               
               
                   
               
               
                 &gt;3300010373|Ga0134128_10000310_109 
               
               
                 [terrestrial-soil-terrestrial soil] 
               
               
                 MAFGNVAKPSRIYTHKSRPPHEGAQLASDQLYRAHQYANALIETERQRWNATQDLMRSMFPRIAELEARIDAINAA 
               
               
                 IEAKNAAVKHQNQAARSRTATAEDRAEVKQLQSERRDAAKELTAERHRQTGVPKPRKEAWERIHAVINATTRDEKE 
               
               
                 RKALRKAAQAAIDAGESPAPLTAEEDREAFGDPEYRRRRAAIDETANADRRAKRAVCEVYWGTYLCVEGAVDKSVE 
               
               
                 DCAKGQPVRNGKPPVPPGPPRFRRWSPEGKLGVQLQGGLSWLDALAGTDSRLRIELQPLAARPTVSKSGKPLPLAD 
               
               
                 PNSRRSRENSQVVVWARIGTEEDGRSPIWMKTVAHLHRHPPADAVIKWVYLQRNLKGVQTWWEAQFVFEREEGWAK 
               
               
                 DRETLRGEAAIDLGWRKVADGLRVAVLIDDDGERMECVLPDSWLESWAKAQSIQGFRDTEFDAIRPALVHWLKARR 
               
               
                 EAGTLPEWLGEATGSLHQWKSCERLGKVVWQWKDQRFDGDEAMFERLVEWRNRDRHLHNYARGMEETAVRRRDEHY 
               
               
                 HRWAALVRRRYALVKVEDTNWREMQHRPEATDDGKNATIGAFRCAAVGRLLETIQEHVWNVVAVEPAWTTKTCHAC 
               
               
                 GHVDDFDSAKELVHTCSACGEIWDQDDNAARGLLKGRVLKWLTREGRKLPKAERVRDVEAAV (SEQ ID NO: 
               
               
                 241) 
               
               
                   
               
               
                 &gt;3300010373|Ga0134128_10011458_1 
               
               
                 [terrestrial-soil-terrestrial soil] 
               
               
                 MFGHESKPSRIWSFKARPPHEGGGLVTEQLRLAHRYRNALVALARRKHEDTEAALLRYRPRLGTLFGLASSLSEAF 
               
               
                 SAAEDSVKARSVAGRRRDVLRGDERKAHAELRRAKEGAWAAYRRERSAAFRVPAVRSELDAIDAAFYSGWRAARGV 
               
               
                 AVNEWGLYWGTYLPAEAAFNQSLKPPGAGKDDASVSAKENIRKRWGPPEFRRRLRGEEFVGHEGAVTVQLQGGLDW 
               
               
                 YAAKLGNDTKLRILPVPAGLTPTTVTRPAFTRAERDRIKRLRREASLVRKELGRLGTPADPGGGDIDGRRSKLVAW 
               
               
                 GHSVRGEIARIRAGATLRTTPLPPPDPGSKRSRAGRRAEVWVRVGSRGPAGREPAWARAVAYIDREPPPGTVIKWV 
               
               
                 HLRRTLAGRSARWSVQFVLSRDSWDAETAAAGAAGVDVNWWMTPVGLRVATAAGSDGSVSHLFVPNDVVDAWRKHE 
               
               
                 SLQSIRSVNADAARAHLLAFRSSGVRLPGWFREASAYAHAWKGGAKLAELVWAWKGRRFPGDAVVYARLEAWRKQD 
               
               
                 RHLHDWHGAQHDKVRRIRNDLYRKWARGLARRFRLGALKDTNYAAVRRAAPAGEEDKGFTRLYSGIASPGLLSRYL 
               
               
                 REAFAECAELPANNVTRECHGCGMVNAFDQARVRFHACQGCGASWDVDENAARNLLRRAAGARREAI (SEQ ID 
               
               
                 NO: 242) 
               
               
                   
               
               
                 &gt;3300010373|Ga0134128_10096594 3 
               
               
                 [terrestrial-soil-terrestrial soil] 
               
               
                 MPTKVYTYGAKLPIHGLELLDDSIIHGHRYYNALIALNRARAEKIDALRHQLIPGLDDAEAAVVAAESGLEDLRAA 
               
               
                 VRQRNAERRTKTATPEDRQAIKAAVASLKEAKAIRKEIRSRCRDCVEYKESLDKVWNDFSEASKAAYNESPCWWGT 
               
               
                 KLHISQSVERAVESSAKIGGVPRFRRWEQVRFDPAAGDDGAFVGAGDGVAAVQLQGGMTVEELLAGADWRLRMEFV 
               
               
                 ADGKRTSLRAARKVIFSLRLGSDGREPRWVRIPAYYHRGGELPVDAKIMWAMIVRRALAPRRQRDGSWRPWYEYSV 
               
               
                 QLTVRTGEARPTADGGICGVNLGWRTKPDGSLRVAVAVGGNQETHECVLPAHMLAGWKLGETLQGHRSVNFDRIRA 
               
               
                 VLADWLRGSTEPPLGLEVSAVELDRLATLANVAEDADRFRRGARTLRAWAANWTRPADLPAWLTTESQYVGLWKSH 
               
               
                 ARLAQLLDRWRSQRFNGDEAAFSALMVWREREAHLQQWETALRKRLDGQRKDIYRKFAARLARRYQVVATEDTDYR 
               
               
                 ALKLRKPAEDNADDAAVKEHMRHGAPGLMRQYLRGRAAVELRIKSKDISRIHIDCGGINSEDRRPSILIVCPHCKV 
               
               
                 EYDQDVNAARNVLARAEVVNETPGAAREAQPKETGDDTLNDGGKRGRWSKRKADRSRKQVESAAQQ (SEQ ID 
               
               
                 NO: 243) 
               
               
                   
               
               
                 &gt;3300010400|Ga0134122_10000107_57 
               
               
                 [terrestrial-soil-terrestrial soil] 
               
               
                 MPIRVFEYGLKAPICNGPLVEQQMRSAHTYRNLLTQMERERRQEVRTIMAAHPDMAPLEARLAEIVTQRDEVRKAI 
               
               
                 TTSRGITRSRSESPELRALARELGKQIREIRAEIKANRQAVAAAVKTDLDRIEIASVRRIKEARAACGVYWGTYLL 
               
               
                 QEADADRARQEAFPPQFRPWRGEGRVSVQLQKGLSIEELHGDDTQLHIDPVPPAAHDIGTRRGDRRRARRTMLRMR 
               
               
                 VQSDGRQPVWAVWPMRYHRPLPPGSVIKVATVSRRRHDCRSWDWMLHITVEIPDAAMKPSPASGVVALNLGFCLRP 
               
               
                 GGTIRAGYIVGSDGVEQEILVPRSVIDAISKCDSIRSIRDKNMDAMKAQMGQWLATVRATHEKIVQEIAARPPPAD 
               
               
                 VDSAWYRFCAYWSMNGPAWPAWFAEATATLHAWRSADRFRRLAFRWRDNRFVGDATGFRILEGYSDQRFHDERDAW 
               
               
                 RYRDEHLERYESGMRRRALLRRRESYRIAAARLSATYRTLLIDDTDLRDFQRSPAPESESIEITRIKRNRGLAAGS 
               
               
                 ELRLTMVNAFNGLSGRVVKISPATKPCHACGVVNTWDRTEDREHTCTACHQRWDQDANACRNMLLAHERDQATDAD 
               
               
                 APSKKRLSRSERLRKNRDAPKAA (SEQ ID NO: 244) 
               
               
                   
               
               
                 &gt;3300010401|Ga0134121_10002041_17 
               
               
                 [terrestrial-soil-terrestrial soil] 
               
               
                 MQRKTTTAPTRVYSYGCSFRGVTKNADLVEEQYRRAHAYQQKLVELELQRRAAVRAVLATDAGVVKLAEVVAQHEK 
               
               
                 ALTDDLVAAAAIKQATRSKKLPPELRDRLAQTKQDLRAARDAWKAARRLFATDPNTKAALDKTNTDHVVAVKAARA 
               
               
                 ASGLAWGTYLILERAADQQRNEKMDPKHRGYTGEGRLAVQFQGGTTVAGVFGGEDTRMRIEPKPGGSRKRHICKLR 
               
               
                 IGSDGRAPIWAEIEVFIHRQLPADSRITWARLKRTRRGRDYLYDLQITLESQTFAGVLQDMAHRRVAVDLGWRVTD 
               
               
                 KGAGGLRVAYWRDSDGRHEELRLPAKLLSSLDYPDQLLGIETNWFERAKAKLLAWRADVVLPEEHRSYTGTLAHWQ 
               
               
                 SPLTLASYVWWWREHRFAGDELIFATMDEWRVRRFWHYRDWRMFQRDKALAARKDFYCVFASKLVVDCKELVLEDF 
               
               
                 DLSAFATKDTGPSAFRYWRRTGAPSELRLCLIAAAKKVGAKITLVDPAMTTRRCQACGSEEPWDQKTETVHTCKTC 
               
               
                 GTTWDQDDNATINMLASGSMVSGTSESLDPAE (SEQ ID NO: 245) 
               
               
                   
               
               
                 &gt;3300004633|Ga0066395_10000027_32 
               
               
                 [terrestrial-soil-tropical forest soil] 
               
               
                 MPITRIYRYGLLEPFLGAELVAEQMSLAHRYQNSLIELERGRRERVRAIMLGAPSLEEAQAIVDRAVKDLLDARQK 
               
               
                 IKDVRKAAQRRAETEADRASVSEIVVRLREARRVLKETRAAVRADSAIALSIAGVNDEIAEEQKRRRAACGVYWGS 
               
               
                 YLLVEQAMDAARKAIVDPRFRRWDGSGRIAVQLQGGLSWADACAGDTRLRVDLAPRAVGKGKPRPTVSLRVGSNGR 
               
               
                 DPVWASWP11LHRPVPEDATIMWAAVHRTILGGKARWHLLLTLRLPDDFVVEKGGKGTVAVDLGWRQRENGLRVGY 
               
               
                 MRDDAGDAGEILLEPAIVDGFKKVDDLRSIRDKRIDVMRPRLAEWLRERELPDWLAAERATMHLWKSAARFSRLAE 
               
               
                 IWRGKRWDGDVEGFDLLWAWRAKDRHLWLWEANLRDKVLARRLDRYRVLGAELARKYHTLVLEDFDLRNLQRHAKP 
               
               
                 ESETVEIGPVRGRQRIAAPSLLRQKLVDAFVARGGRVVEVPSANTTRSCHACGLVEAWDPVTNLMHACTGCGALWD 
               
               
                 QDDNACRNLLLRERLGADEASEAARPTETEPKTSKWGRLGRHKKRPLASGNANE (SEQ ID NO: 246) 
               
               
                   
               
               
                 &gt;3300005332|Ga0066388_100004304_4 
               
               
                 [(terrestrial-soil-tropical forest soil) 
               
               
                 MLVGWFRYNEARPAGGDVATCNNATMKRSEFNGRVLVYRFRCPVAASNIPEAAETQFRLAHELRNELVAVERAHAD 
               
               
                 AVAAIWADHPDVAATLQAQAVAEAAVAELVERAGKERIADRAKEPRAQTRAEIKAARATLAAARQDTKAARSAAYP 
               
               
                 LVRPAMADAQTRRRQAIGDAGRGAKTRGLFWHTHDAVLAGHDTAVKRVAALRAEGKPAELRSRRWDGEGRIRVTLM 
               
               
                 RHEWSHGCGAQPCGQPSPECPRRQPGDPLRTPALLAGGQGPWRNVCRLPAHMDPAICAEHPPRRHGERETILLRVG 
               
               
                 SEEREPIWWELPVFVHRPLPPGADVAFVEVRRERLAGQTRLSVCVTVRLPPVATLTEGAVAAIHPGWRSVTGGIRV 
               
               
                 MVIAASRPLGPIPERFAPVVRPLTGNHVEIIAPEEWVRVLGHADSVRSIRDQALDVIRRKIVDALAEDVPGVEVSA 
               
               
                 ADVARWRSPGRFAALVRQWPNDHPLADVLWAWRRQDRHLWKGEAHERDQIAARRTDTWRHVAVWLCDQVAVIGHAP 
               
               
                 TPIAELSRVPVIEDGDDRQATLARAHRALAAPAELVSLIEIAAGQRGVRIVEIDGARLTATHHVCGEVTGDLARDS 
               
               
                 VMLWCSRCGIAFDQDANAATASLARTIGDLSSAKVQ (SEQ ID NO: 247) 
               
               
                   
               
               
                 &gt;3300005332|Ga0066388_100004304_2 
               
               
                 [(terrestrial-soil-tropical forest soilj 
               
               
                 MKRSEFNGRVLVYRFRCPVAASNIPEAAETQFRLAHELRNELVAVERAHADAVAAIWADHPDVAATLQAQAVARAA 
               
               
                 VAELVERAGKERIADRAKEPRAQTRAEIKAARATLAAARQDTKAARSAAYPLVRPAMADAQTRRRQAIGDAGRGAK 
               
               
                 TRGLFWHTHDAVLAGHDTAVKRVAALRAEGKPAELRSRRWDGEGRIRVTLMRHEWSHGCGAQPCGQPSPECPRRQP 
               
               
                 GDPLRTPALLAGGQGPWRNVCRLPAHMDPAICAEHPPRRHGERETILLRVGSEEREPIWWELPVFVHRPLPPGADV 
               
               
                 AFVEVRRERLAGQTRLSVCVTVRLPPVATLTEGAVAAIHPGWRSVTGGIRVMVIAASRPLGPIPERFAPVVRPLTG 
               
               
                 NHVEIIAPEEWVRVLGHADSVRSIRDQALDVIRRKIVDALAEDVPGVEVSAADVARWRSPGRFAALVRQWPNDHPL 
               
               
                 ADVLWAWRRQDRHLWKGEAHERDQIAARRTDTWRHVAVWLCDQVAVIGHAPTPIAELSRVPVIEDGDDRQATLARA 
               
               
                 HRALAAPAELVSLIEIAAGQRGVRIVEIDGARLTATHHVCGEVTGDLARDSVMLWCSRCGIAFDQDANAATASLAR 
               
               
                 TIGDLSSAKVQ (SEQ ID NO: 248) 
               
               
                   
               
               
                 &gt;3300005764|Ga0066903_100000051_27 
               
               
                 [(terrestrial-soil-tropical forest soil] 
               
               
                 MPITRIYRYGLLEPFLGAELVAEQMSLAHRYQNSLIELERGRRERVRAIMLGAPSLEEAQAIVDRAVKDLLDARQK 
               
               
                 IKDVRKAAQRRAETEADRASVSEIVVRLREARRVLKETRAAVRADSAIALSIAGVNDEIAEEQKRRRAACGVYWGS 
               
               
                 YLLVEQAMDAARKAIVDPRFRRWDGSGRIAVQLQGGLSWADACAGDTRLRVDLAPRAVGKGKPRPTVSLRVGSNGR 
               
               
                 DPVWASWPIILHRPVPEDATIMWAAVHRTILGGKARWHLLLTLRLPDDFVVEKGGKGTVAVDLGWRQRENGLRVGY 
               
               
                 MRDDAGDAGEILLEPAIVDGFKKVDDLRSIRDKRIDVMRPRLAEWLRERELPDWLAAERATMHLWKSAARFSRLAE 
               
               
                 IWRGKRWDGDVEGFDLLWAWRAKDRHLWLWEANLRDKVLARRLDRYRVLGAELARKYHTLVLEDFDLRNLQRHAKP 
               
               
                 ESETVEIGPVRGRQRIAAPSLLRQKLVDAFVARGGRVVEVPSANTTRSCHACGLVEAWDPVTNLMHACTGCGALWD 
               
               
                 QDDNACRNLLLRERLGADEASEAARPTETEPKTSKWGRLGRHKKRPLASGNANE (SEQ ID NO: 246) 
               
               
                   
               
               
                 &gt;3300010047|Ga0126382_10001209_14 
               
               
                 [(terrestrial-soil-tropical forest soil] 
               
               
                 MDNAAYRVLVGWFRYNEARPAGGDVATCNNATMKRSEFNGRVLVYRFRCPVAASNIPEAAETQFRLAHELRNELVA 
               
               
                 VERAHADAVAAIWADHPDVAATLQAQAVAEAAVAELVERAGKERIADRAKEPRAQTRAEIKAARATLAAARQDTKA 
               
               
                 ARSAAYPLVRPAMADAQTRRRQAIGDAGRGAKTRGLFWHTHDAVLAGHDTAVKRVAALRAEGKPAELRSRRWDGEG 
               
               
                 RIRVTLMRHEWSHGCGAQPCGQPSPECPRRQPGDPLRTPALLAGGQGPWRNVCRLPAHMDPAICAEHPPRRHGERE 
               
               
                 TILLRVGSEEREPIWWELPVFVHRPLPPGADVAFVEVRRERLAGQTRLSVCVTVRLPPVATLTEGAVAAIHPGWRS 
               
               
                 VTGGIRVMVIAASRPLGPIPER FAPWRPLTGNHVE11APEEWVRVLGHADSVRSIRDQALDVIRRKIVDALAEDV 
               
               
                 PGVEVSAADVARWRSPGRFAALVRQWPNDHPLADVLWAWRRQDRHLWKGEAHERDQIAARRTDTWRHVAVWLCDQV 
               
               
                 AVIGHAPTPIAELSRVPVIEDGDDRQATLARAHRALAAPAELVSLIEIAAGQRGVRIVEIDGARLTATHHVCGEVT 
               
               
                 GDLARDSVMLWCSRCGIAFDQDANAATASLARTIGDLSSAKVQ (SEQ ID NO: 249) 
               
               
                   
               
               
                 &gt;3300010047|Ga0126382_10001209_12 
               
               
                 (terrestrial-soil-tropical forest soil] 
               
               
                 MKRSEFNGRVLVYRFRCPVAASNIPEAAETQFRLAHELRNELVAVERAHADAVAAIWADHPDVAATLQAQAVAEAA 
               
               
                 VAELVERAGKERIADRAKEPRAQTRAEIKAARATLAAARQDTKAARSAAYPLVRPAMADAQTRRRQAIGDAGRGAK 
               
               
                 TRGLFWHTHDAVLAGHDTAVKRVAALRAEGKPAELRSRRWDGEGRIRVTLMRHEWSHGCGAQPCGQPSPECPRRQP 
               
               
                 GDPLRTPALLAGGQGPWRNVCRLPAHMDPAICAEHPPRRHGERETILLRVGSEEREPIWWELPVFVHRPLPPGADV 
               
               
                 AFVEVRRERLAGQTRLSVCVTVRLPPVATLTEGAVAAIHPGWRSVTGGIRVMVIAASRPLGPIPERFAPVVRPLTG 
               
               
                 NHVEIIAPEEWVRVLGHADSVRSIRDQALDVIRRKIVDALAEDVPGVEVSAADVARWRSPGRFAALVRQWPNDHPL 
               
               
                 ADVLWAWRRQDRHLWKGEAHERDQIAARRTDTWRHVAVWLCDQVAVIGHAPTPIAELSRVPVIEDGDDRQATLARA 
               
               
                 HRALAAPAELVSLIEIAAGQRGVRIVEIDGARLTATHHVCGEVTGDLARDSVMLWCSRCGIAFDQDANAATASLAR 
               
               
                 TIGDLSSAKVQ (SEQ ID NO: 248) 
               
               
                   
               
               
                 &gt;3300010048|Ga0126373_10000093_102 
               
               
                 [(terrestrial-soil-tropical forest soil] 
               
               
                 MPIRVYQFGLLPPIDGEARVRVLMRQCHEYRNELVAIERGRRAALRALHDTQEVADAVALVKASKGKPLREAIGKL 
               
               
                 YKARRAAEKAASHCPGVAEASVPEDASDAERSRLRRVNLEARAAAGDAVARITLLDESIRRDARALSPLSPGAWAN 
               
               
                 YQTIEAAATQVRAMPLYERDAVTPSDPRFVKGPRAGQAFPVSNPKSCWWLGDQQVSMHIQGRTVTTADVLAGKDAW 
               
               
                 VRLELEPARLHGGTNGGKQQYSQYGVLKLRVANDTRCAVWASWPIKLHRAIPNAAKWQWVRVSCRRLARREVWTVE 
               
               
                 ITLNDPQKIQPRPDVSGAVAVELLWTPLDDGSMRVASWRDSFGATGELLMSSRMVGAIRKADGIRSVRDTLLNALR 
               
               
                 PALAEKIQHSADKLPTWLREVGNVLHLWKSQDRFYELALRWRKDKVDAARDAYELLQEWELRDAHLLDYEAGSRRN 
               
               
                 GIGWRNHYYSNWAAGLARRYKAVIVPDRDLSLEARFGDDSDRRTTVSPQKLRDMLLNAFGEDAVKAVWKGPHGVPE 
               
               
                 DSDDTWLEVVSEQWRNEENTGGACAAEKDNAVADVGGSAWAKRKARARERAAGKDGARKDVGNTAE (SEQ ID 
               
               
                 NO: 250) 
               
               
                   
               
               
                 &gt;3300010366|Ga0126379_10001683_10 
               
               
                 [(terrestrial-soil-tropical forest soil) 
               
               
                 MFGRKRDTAGATIRAYEFGTRPVGDMALASQQLYRRHQLWNQFVEIERDTRAKYRALVATESTQRVAALHEQLEEL 
               
               
                 RQQIRLHKKSAAYEHVLHGKLRSLVEAKQSALADRSPETVAIVKPRLYFADIVSYDGLRERAKQLRQALGVMRAEA 
               
               
                 KAESRAKAEQLKAEREQLERERTDRVKAAMAASNLYWCNSDDVRASYBVARKRAMREGTELHFHRFDGGGKLSVRY 
               
               
                 QQGLPVAAAFGTDTRLQIDPIDFSIWESADRAVRRRCWTKARLRIGSNDQRQPVWLTLDCWLDGRPGRHLPMEGTI 
               
               
                 RAAAVIRRRVGTGFTHRLVLTVEAPLERRDLAVERHGTVGLDVGWRLTADNGLRVAYWSDGTAQGALTLPANMVGL 
               
               
                 FEKVHDLQSIRGQHFNAAVERLQGYLEEHPGAMWLQEQCRYIAQWRSPGRLIVLLRDWQSDGTDGELLEHLQAWRK 
               
               
                 KEDHLYSWQANLLDQTAAHRRELYRIFAASLGRYARVAIEEFDLRKVLQKPRPEDGAETPDGHMRTIAAVSVLRSA 
               
               
                 IENYCRREGVEFVVVPSSGTTRRCHVCQSEQQFDQRSDLVHRCTTCGETWDQDYNAAENIRQFADRPAGDTILPSA 
               
               
                 KISPEAPEARV (SEQ ID NO: 251) 
               
               
                   
               
               
                 &gt;3300010376|Ga0126381_100020658_4 
               
               
                 [terrestrial-soil-tropical forest soil] 
               
               
                 MIVHTLYIKTVDSETRKAVLAQMRAGHNYRNELVAIERGRRWALRQAHETPEVAEAIALLKAATRSNRFERLKALT 
               
               
                 RARRQAEEAIEKPQVYLACEAARIALRDEAAGTPRKKAAQAVYDAAREALCQSDEFHYAVGERDNWIRKAAYNDAK 
               
               
                 CNWGIRAVVNQAFEALRKTGLYERDGVTAWEPRFRRWAPNRPTGTIGVQLQGGLDVKDALSGDDTQVKLLLNPPIY 
               
               
                 KGSRQQRVRQFGELWVRIGSDGRSPIWARFNVMAHRALPTDAKIKWVKVHLTRTGPFERWEAHLTLDASAPPRPIT 
               
               
                 NDRAVAVELLWSPQDDGSITAAHWRDGDGAEGFFALPAIIPTSIRKPDGIQSVRELLLNKMRPDLVALIKHYGSDL 
               
               
                 PVWLKEATNTLHLWESPLRFYDLAQCWRDSGFMGAKGAYDRLHEWELRDDHLWRYEACARKTAIRRRRDFYSCLAK 
               
               
                 NLSAQYRYVILPDRDLSRERRFGEERDIQFTVAPQELRAALTRCFGDETIEAPWRGAHGVEEDEYGDIDWLLFALE 
               
               
                 YGRDEKEARAAREAAKSSGDVKLTGGKWARIKAKRKEKDDAERGTRKESGKDAEGLGGER (SEQ ID NO: 
               
               
                 252) 
               
               
                   
               
               
                 &gt;3300010398|Ga0126383_10032213_5 
               
               
                 [terrestrial-soil-tropical forest soil] 
               
               
                 MKRQAENVRSMVYQYGTVPARVAPVEGEELALSQMRLAQRLWNVLVTIERARVAGYRSIMRDEVQEQIDALRERKD 
               
               
                 ATWQEIKATRQKARAKVATPGLDAEMMRIKTALRLLVEHKQSTKQQRHDARREQLNALAERANQRIKRARQAAASM 
               
               
                 GLFWGTYNAVIQSADAGRKHAGELRYQGFRGEGTVTAQVMGGATPEQCVAGGHPFFQVAPATPGQKWRYARVRIGS 
               
               
                 TSERQPLWVAIPVVYHREIPAEARIKSVSATRRILAGKVRWSLNVTVTLPPAEPRPAGQKVAIDIGWRLLPDGVRV 
               
               
                 AYWQDGTGNHSEVRIADSDIAQFRKISDLRSICDRAREEFLPSLVEWLKPYELDEEWTHRARALAQWRSNDRIAAL 
               
               
                 IRWWADHRLSGDAEIYQTAVEWRRQYLHLANWWRNQQEQMTLRVREQYRRFAAGIASQFATVIVEDFDLRQVTETT 
               
               
                 EKAVGTYRQMVSPSLFRAAVINACKREGVEIRIVSGAYSTGACHNCQHIEVWDQAASILHRCGACGALWDQDHNAA 
               
               
                 INLLASGGVVLWRINLVAAIGPLSQDRSQTGGKEAVES (SEQ ID NO: 253) 
               
               
                   
               
               
                 &gt;3300017961|Ga0187778_10004454_1 
               
               
                 [terrestrial-soil-tropical peatland] 
               
               
                 MTARVYEYGLLDPTYNAQLVDDQMRAGHRYRNVLVEIERDRRTEVRNLLARHPDVEPLEAELLAARNDLADRRGQI 
               
               
                 RLQRKSTRTRSEGASMREAAHAAKLRVAEIRQRVNDAKAAIKEDAVVQAAIATADARAAERVRQARASCATYWGTY 
               
               
                 ILHEADVARARASGGEVHFARWTGEGRVSAQIQGGIPSTDLAADTQVQIAPGQSIKDRRVPPNAKILRLRVQSDAK 
               
               
                 GKAIWAEWPMILHRPLPEEGRIKVVTVHKRRRDCRRWQWTVTFTVELLDGWTRGKCGEGAIALNLGYCRSYDHLKG 
               
               
                 AIRAGYLIDDRGQEREVIVPTSIIDRINKSEAIRSQRDKDVDTMRALLVAWLRDHEAILPGWIVDRTILAKAPKDA 
               
               
                 NSPEAPRIWHITAWKSAARFRALAFAWRAARFQGDDVGYDLIERWRYRDEHLQRYEAGLLRGALLHRRDLYRQLAA 
               
               
                 ELSAKYRTIVLHDTDLSDLQRS PHPEEDRREIGGAKYNQRIAAGSILRGALDNAFKRAGGEWIVDDHRITKACWK 
               
               
                 CSEAEDWNQLDREHICGACGTRWDQDANACHNMLARERAGAEGRRQAARAAKTADRKETRSERLRRGLATKRKTEA 
               
               
                 ARAM (SEQ ID NO: 254) 
               
               
                   
               
               
                 &gt;3300017970|Ga0187783_10000008_23 
               
               
                 [terrestrial-soil-tropical peatland] 
               
               
                 MFGNKSLPSRIYSYGANPAIENQKLVEDQMFLAHRYRNAMVEAEIERRKKVDEKLLSLSPSLARIEEKLAAATEEL 
               
               
                 EKLRESIKEDHKLYFTKTAKDPVKTKAIAAQKKLVKGLYTERKALRTKLFASSKWKKEQEAIEAEALAAHKELREK 
               
               
                 SDLYWGTYLLVEQSMQGSRSGAPPRFMRWDGDGHIALQIQNGMTVEEALSGADTRLA11PGRVEVDGSRTKETGIK 
               
               
                 RKLGTALCKFRIGTDEKTHSPIFASIPFHMHRPLPEDAQIKWVHFIRRRVSTHCEWRLQFVLSQKKWVKEDQAQEG 
               
               
                 TVGIDLGWSLDQEGYLQVACFAGSDGESGRLFLPADWLGEMKRVEGIRSIRDQNFNDAKALLQAFLRTSKEKSWLK 
               
               
                 EEAKTLPQWRSPAKLAWVIQKWRKERIPGDQHIFQAMEAWRLRDKHLYEFEANLRDQLLRRRESIYRNFAADLRRS 
               
               
                 YKTARILKLALKEVHELPQAEEAPENPQLREHSRDACLSFLVRCLRESMARTVEIDPKNQARRHHGCGSLEDLGAN 
               
               
                 EKLHTCSRCGEIYERHENTARNLLGMMPAGAGV (SEQ ID NO: 255) 
               
               
                   
               
               
                 &gt;3300017972|Ga0187781_10019688_5 
               
               
                 [terrestrial-soil-tropical peatland] 
               
               
                 MERLPTETSPLDVVEMEREIDEARTATGWPTATVVHRYGIASPHEGADIVHEQIRLARAYRRELVTIERARRAAAR 
               
               
                 QAMTELAPEVGFAEATVVGADAACQWLAAEIRAARAATRKRAESRGMRDRLTRARASLRTHRAELFALRSRYATQC 
               
               
                 ADCRKAKSESVPCPHATAEARRLLERVDAVNDQAAAAQRRARGECGVYWGSYLLVERAMQASRAMPLYADDGVSPN 
               
               
                 DPSVPHSLSDSLGCQIQSTRPLTVAGAAAGTDSRLRIQPPPWPEAWLHEARLDPSAQSHPSHRLPGQRPDGTPAPA 
               
               
                 TRADGTPARWVRDRACRQGEVRMRVGANGEWAAWRLDEHRAMPPNAAVKWATVVRRQRGPHTEWSLCLTLEVPLPE 
               
               
                 ALPQTGRTVAVDVGWRQIGDELRVAAWQDSDGQKGELRLTKADLHALNASAEVRSLRDGKMESIKQRLAQWSAVAS 
               
               
                 PQDCPEWIREALRTVRLWRNPVRLVRLLRQWREAGEPTRVVPRVAFDHLVAWADDDRHRWAEQESRRVWGLRRRRE 
               
               
                 RYRVFAAELAKRYDAVVLEQFDLRRVAARPQTGRELESENEVARSNRQRASVSELRDALRNACRSRGRVVVAVDAT 
               
               
                 DSTRTCPSCGLVADRGQDERVVLRCECGHEWDQDRDGAALVLLRRYREHPGDAKTLVAARAGATLAEPPKKKNDRW 
               
               
                 ARARRMSTQKKERAQGARDSG (SEQ ID NO: 256) 
               
               
                   
               
               
                 &gt;3300018064|Ga0187773_10011230_2 
               
               
                 [(terrestrial-soil-tropical peatland] 
               
               
                 MENQGEESAAAVPSEEEAPLDARVYQFGLLPPRVNRDLVEDQMYLGHRYRCQLVEFERDRRDAVREILSSQSGVEE 
               
               
                 IEARIADLAARRDAARAEIASKRSRSRSRSDSAEERATVREIGRQLKALRAEAKEARSIVASDEHVGAWISAENDR 
               
               
                 AAQRQKDARVACGVYWGTYLLHESDAQRARTGKSYPKFPRWNGDGRVAVQLQGGLSPQKLDHGQDTRLQVVSSSHR 
               
               
                 TGRRLGRGSLLRMRVQSNGRDPVWAEWPMILHRPLPEGVRIKTATVSRRRRGSQVDWCATITVDEPPRPIRATATE 
               
               
                 EAVAINLGYARRPNGGIRVGYWVGSDGAGGEILCQGSAAYRPRSSEEQIRAAVTHVEESLKKADSIRSFRDRGMNE 
               
               
                 MRARLIAWIDDFVGGDPPDGVPWWIADARRHLHLWRSPNRFASLLRRWERGWWPDLDGGYAILLAWSRRDLHLERY 
               
               
                 ETGMRTTARRDRREGYRLLAARLAARYRTLVVDDADFRNFQRSPEPESDYVEVDAQKWQQRVASPSELRFAFLSAF 
               
               
                 GVDRTAKEPCEDVTRRHAPCGHVVDVAGDSRELRCPHCSEVEKREVLFDQDANACDNLLRGWLRKAPEMRQARTKR 
               
               
                 PPSIRRQRMIAGAKKKREAKAAEERRREARGG (SEQ ID NO: 257) 
               
               
                   
               
               
                 &gt;3300012204|Ga0137374_10001132_4 
               
               
                 [terrestrial-soil-vadose zone soil] 
               
               
                 MATLVYRYGVRAHGSARQQDAVVSDPAMLEQLRLGHELRNALVGVQHRYEDGKRAVWSGFASVAAADHRVTTGETA 
               
               
                 VAELEKQARAEHSADRTAATRQGTAESLKAARAAVKQARADRKAAMAAVAEQAKPKIQALGDDRDAEIKDLYRRFC 
               
               
                 QDGVLLPRCGRCAGDLRSDGDCTDCGAAHEPRKLYWATYNAIREDHQTAVKLVEAKRKAGQPARLRFRRWTGDGTL 
               
               
                 TVQLQRMHGPACRCVTCAEKLTRRARKTDPQAPAVAADPAYPPTDPPRDPALLASGQGKWRNVLQLGTWIPPGEWS 
               
               
                 AMSRAERRRVGRSHIGWQLGGGRQLTLPVQLHRQMPADADVAMAQLTRVRVGGRHRMSVALTAKLPDPPQVQGLPP 
               
               
                 VALHLGWRQRPDGSLRVATWACPQPLDLPPAVADVVVSHGGRWGEVIMPARWLADAEVPPRLLGRRDKAMEPVLEA 
               
               
                 LADWLEAHTEACTARMTPALVRRWRSQGRLAGLTNRWRGQPPTGSAEILTYLEAWRIQDKLLWERESHLRRRLAAR 
               
               
                 RDDAWRRVASWLARHAGVLVVDDADIAELRRRDDPADTDPTMPASAAQAARARAALAAPGRLRHLATITATRDGLG 
               
               
                 VHTVASAGLTRLHRKCGHQAQPDPRYAASAVVTCPGCGNGYDQDYNAAMLMLDRQQQP (SEQ ID NO: 258) 
               
               
                   
               
               
                 &gt;3300012210|Ga0137378_10000107_47 
               
               
                 [terrestrial-soil-vadose zone soil] 
               
               
                 MENNITVMRYGARVPITGLESVDRQLRLSKKYRNALCEIERRRRDGIARVQHGTRAGASPLDADELLAPLILKIDE 
               
               
                 LEASISEMRKQTKLTHAGGGNPAARASLRDQIAAVKADLAVLRWLRGWSKSRLRLSDDERAAIAMCDGEKMSAWMI 
               
               
                 HRVKPWWALGVAVHATMNGSAALRLRCEYMIIDETAKYERRQARAVAGLSPGTYLLIEAAADKWRQNPEQPRFMRY 
               
               
                 DGTGRVGVQVQGGCTVAELEGGQDTRMRLLPATEIDPPVAPTSSRQIARAIAYGVVHFCRAGNMAPRDTYRILQLR 
               
               
                 VETMGRAPVWASIPIVYHRPLPADGVIVAAWLQRKKIGVRSVYDAQLVVRAAMTPQSHRPTTGTIAVDIGSRDIPS 
               
               
                 TGETRVAYSLDSSGAHAAMILPLFRLSSATSRGTGRRRIVPDDEKKIDDIKSIRSRHLDEIRDQITAYKVSVGAAA 
               
               
                 SSPHPVPAIEWLRAATDRITSWRSPARIVWLRRQWQHHTGDEKIFSSIEAYIRQDRHLLDWQSREMRRRLGRRREL 
               
               
                 YRTAAMRLARTYDTIILAARDYRREEWVPEDAPSTRAHESRSIMRGAAPGEFREIIRRSAKKYGTTLIEMPLEGDT 
               
               
                 AWALDYRVCQRMLASTEVVDVQAAPLASASRSNHYGTDESFHRRRLGTDERIDPLARIDVSG (SEQ ID NO: 
               
               
                 259) 
               
               
                   
               
               
                 &gt;3300012532|Ga0137373_10000316_4 
               
               
                 [terrestrial-soil-vadose zone soil] 
               
               
                 MATLVYRYGVRAHGSARQQDAVVSDPAMLEQLRLGHELRNALVGVQHRYEDGKRAVWSGFASVAAADHRVTTGETA 
               
               
                 VAELEKQARAEHSADRTAATRQGTAESLKAARAAVKQARADRKAAMAAVAEQAKPKIQALGDDRDAEIKDLYRRFC 
               
               
                 QDGVLLPRCGRCAGDLRSDGDCTDCGAAHEPRKLYWATYNAIREDHQTAVKLVEAKRKAGQPARLRFRRWTGDGTL 
               
               
                 TVQLQRMHGPACRCVTCAEKLTRRARKTDPQAPAVAADPAYPPTDPPRDPALLASGQGKWRNVLQLGTWIPPGEWS 
               
               
                 AMSRAERRRVGRSHIGWQLGGGRQLTLPVQLHRQMPADADVAMAQLTRVRVGGRHRMSVALTAKLPDPPQVQGLPP 
               
               
                 VALHLGWRQRPDGSLRVATWACPQPLDLPPAVADVVVSHGGRWGEVIMPARWLADAEVPPRLLGRRDKAMEPVLEA 
               
               
                 LADWLEAHTEACTARMTPALVRRWRSQGRLAGLTNRWRGQPPTGSAEILTYLEAWRIQDKLLWERESHLRRRLAAR 
               
               
                 RDDAWRRVASWLARHAGVLVVDDADIAELRRRDDPADTDPTMPASAAQAARARAALAAPGRLRHLATITATRDGLG 
               
               
                 VHTVASAGLTRLHRKCGHQAQPDPRYAASAVVTCPGCGNGYDQDYNAAMLMLDRQQQP (SEQ ID NO: 258) 
               
               
                   
               
               
                 &gt;3300012532|Ga0137373_10000407_43 
               
               
                 [terrestrial-soil-vadose zone soil] 
               
               
                 MIVYRYGALKPTEGFDLLLTQLRLACRYRNALVELLNWRIIAEQSGVERSAAKLVHAEMSCWLRSRCGLGWGTYQA 
               
               
                 IEADVRRAAKSPYRAPRKVSGRARWFAQVRQIKIQRPPDADGNQDAQVREIGLDPTKFRARFRRFDGTGRLGANIQ 
               
               
                 ACSGATTDDVLSGRGSLRLSAPEGRVTARLYLGLGIHVTLPVIAHRPLPPGVQVVRALICVERVGDRYVYSVHVTM 
               
               
                 RHERPERQYGSGRAAINFGWRSLGDRGVRIAYVATDEGSTDELILPRRLIDKLRHSESLRGLADDAAVAYLGDARG 
               
               
                 RTRARREALRDPSATHRELGRVPIEGEPISAEHWARRDRHLYQWERDEYAKVLRQRREIYRLWVRSLAAKYGSVVM 
               
               
                 EDYDLPTLISRDQPTEIPEARHVRFLVAPGSLRAEVQSVFGERATLATIKRRTNVCSVCGCELTGDRVRDVVLYCE 
               
               
                 QCDAQRDQDANNAANQLIDTAAE (SEQ ID NO: 260) 
               
               
                   
               
               
                 &gt;3300012930|Ga0137407_10020190_4 
               
               
                 [terrestrial-soil-vadose zone soil] 
               
               
                 MSTIVYRFGVHGAPLDNLELVKQQMRAAHNYANDLVAIERGRRTALHAIDDVPDVRNTIETVRQSTKSTRKAAITA 
               
               
                 LRLARKAARAAAEEELARVQALDESIRRDARAITVCYWGSYLTIEMSAQQQRSQPLYEDDAITPNLPRFRGWREEG 
               
               
                 QIGIQIQKGLPTSAVRACTDTRARLDRSDRKKQGSKGRSVEYADLWIRIGSDGRAPIWTRVRVIMHRQIPDAAQWK 
               
               
                 WVRLSYRREGRTFAWSVEISVDVDRPKRTLDTTLRGAIAIEPQWSENADGSIVCATYRTEDGSSGEIELSPRIVGA 
               
               
                 LRKADSIRAVRDMILNEARKDIHRALVEAGPALPVWLKDARNTMHLWKSQERFYRLANHWRRERCDAAREAYDRLQ 
               
               
                 EWELRDDHLWRYEAGSRGQAIRSRNDFYHVIASQFARKHRFVIVPKRDYSREARFGAESDLRFIVSPSSLVSALDC 
               
               
                 SFDHGESAYVCPWVRPDGDGDSAEWPAIAIBRFCAGDSAMIARKIRKENDSEEKQESAWARRKRLKREKEMRLATA 
               
               
                 RITDGNGTKSLGQ (SEQ ID NO: 261) 
               
               
                   
               
               
                 &gt;3300005987|1071089|scaffold14955_2 
               
               
                 [wastewater-nutrient removal-wastewater effluent] 
               
               
                 MSTLVYRFGLLPPHENDALVRSQMRLAHRYRNDLVQIERARRAAVRDVARAAPEVARLELEAARTDAACAKVGGQI 
               
               
                 KAARAAGRTRKDSVELIEQLKALRIEHKEWLALREAR KTARVAAEPVLAEIEERVAAMRRGARAICGVYWGTYLM 
               
               
                 IEDADQAMRKMPLYDKDAEPSDPRFVPWTGDGSVGVQIQGGMTGEDTADDTRLRIESAAPPPGADPNSKRSLRRRY 
               
               
                 CVLAMRVGSEGRDPVWARWRMVMERPLPADARIKRAAVKLRRVGPREEWSVTITLETAERDRRVSDQVGMVGIDLG 
               
               
                 WRLMPDGLRVAAWHGSDGASGFLTLPDTRPTFHTTPGGRTRSSALGVVDAARKVEDLSSKRDKAFNEARSAIARIE 
               
               
                 GAPPWFELATKTISQWKSQGRLAALVRRWRDARWDGDAEAYEEAEKWRYHDHHLWAWETSQQAKALRARREVFRLF 
               
               
                 AADMAKRYARLAIEGLDLRAFARKTDDDTNETARRNRVVVAPSKLREALLLAFGSAINHWAETPKGDRVVVVEAAG 
               
               
                 TTMVHHECGSVERWDQATHVSHLCSSCGEIFDQDANAAKNILAAGERLGGPVLSGAARNDENVSNLSQVREGRWAK 
               
               
                 AKRMKAEKDARLEAARKAAPSAAE (SEQ ID NO: 262) 
               
               
                   
               
               
                 &gt;3300005988|1071091|scaffold06014_8 
               
               
                 [wastewater-nutrient removal-wastewater effluent] 
               
               
                 MSTLVYRFGLLPPHENDALVRSQMRLAHRYRNDLVQIERARRAAVRDVARAAPEVARLELEAARTDAACAKVGGQI 
               
               
                 KAARAAGRTRKDSVELIEQLKALRIEHKEVVLALREARKTARVAAEPVLAEIEERVAAMRRGARAICGVYWGTYLM 
               
               
                 IEDADQAMRKMPLYDKDAEPSDPRFVPWTGDGSVGVQIQGGMTGEDTADDTRLRIESAAPPPGADPNSKRSLRRRY 
               
               
                 CVLAMRVGSEGRDPVWARWRMVMERPLPADARIKRAAVKLRRVGPREEWSVTITLETAERDRRVSDQVGMVGIDLG 
               
               
                 WRLMPDGLRVAAWHGSDGASGFLTLPDTRPTFHTTPGGRTRSSALGVVDAARKVEDLSSKRDKAFNEARSAIARIE 
               
               
                 GAPPWFELATKTISQWKSQGRLAALVRRWRDARWDGDAEAYEEAEKWRYHDHHLWAWETSQQAKALRARREVFRLF 
               
               
                 AADMAKRYARLAIEGLDLRAFARKTDDDTNETARRNRVVVAPSKLREALLLAFGSAINHWAETPKGDRVVVVEAAG 
               
               
                 TTMVHHECGSVERWDQATHVSHLCSSCGEIFDQDANAAKNILAAGERLGGPVLSGAARNDENVSNLSQVREGRWAK 
               
               
                 AKRMKAEKDARLEAARKAAPSAAE (SEQ ID NO: 262) 
               
               
                   
               
               
                 &gt;3300006056|1071094|scaffoldl18627_2 
               
               
                 [wastewater-nutrient removal-wastewater effluent] 
               
               
                 MSTLVYRFGLLPPHENDALVRSQMRLAHRYRNDLVQIERARRAAVRDVARAAPEVARLELEAARTDAACAKVGGQI 
               
               
                 KAARAAGRTRKDSVELIEQLKALRIEHKEVVLALREARKTARVAAEPVLAEIEERVAAMRRGARAICGVYWGTYLM 
               
               
                 IEDADQAMRKMPLYDKDAEPSDPRFVPWTGDGSVGVQIQGGMTGEDTADDTRLRIESAAPPPGADPNSKRSLRRRY 
               
               
                 CVLAMRVGSEGRDPVWARWRMVMERPLPADARIKRAAVKLRRVGPREEWSVTITLETAERDRRVSDQVGMVGIDLG 
               
               
                 WRLMPDGLRVAAWHGSDGASGFLTLPDTRPTFHTTPGGRTRSSALGVVDAARKVEDLSSKRDKAFNEARSAIARIE 
               
               
                 GAPPWFELATKTISQWKSQGRLAALVRRWRDARWDGDAEAYEEAEKWRYHDHHLWAWETSQQAKALRARREVFRLF 
               
               
                 AADMAKRYARLAIEGLDLRAFARKTDDDTNETARRNRVVVAPSKLREALLLAFGSAINHWAETPKGDRVVVVEAAG 
               
               
                 TTMVHHECGSVERWDQATHVSHLCSSCGEIFDQDANAAKNILAAGERLGGPVLSGAARNDENVSNLSQVREGRWAK 
               
               
                 AKRMKAEKDARLEAARKAAPSAAE (SEQ ID NO: 262) 
               
               
                   
               
               
                 *Effector proteins having identical amino acid sequences were identified from different sources and assigned the same sequence identifier. 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Nucleotide Sequences of Representative CLUST.018837 Direct Repeats 
               
            
           
           
               
               
            
               
                 Effector Accession 
                 Direct Repeat Nucleotide Sequence 
               
               
                   
               
               
                 WP_081130164.1 (SEQ ID NO: 1) 
                 GTTTCATCGGCCATCGCGGCGGCCTCGTAGCTGCGAC (SEQ ID 
               
               
                   
                 NO: 27) 
               
               
                   
               
               
                 WP_018079340.1 (SEQ ID NO: 2) 
                 GTTTCATCAGCCATTGCAGGGGCTTTG (SEQ ID NO: 28) 
               
               
                   
               
               
                 WP_064217851.1 (SEQ ID NO: 3) 
                 GTGTTATGCCCATCTCAGCGGGCTGGTTGCTGAGAC (SEQ ID 
               
               
                   
                 NO: 29) 
               
               
                   
               
               
                 JMEB01000165_11 (SEQ ID NO: 4) 
                 GTTATAGTGGCCATTGTAGGGGCTT (SEQ ID NO: 30) 
               
               
                   
               
               
                 WP_051690567.1 (SEQ ID NO: 5) 
                 GTTATAGTGGCCATTGTAGGGGCTT (SEQ ID NO: 30) 
               
               
                   
               
               
                 OJW42488.1 (SEQ ID NO: 6) 
                 GGTTTAAGGCGATCACGGCCGCCTAGTTGCCGCGAC (SEQ ID 
               
               
                   
                 NO: 31) 
               
               
                   
               
               
                 LNFM01018448_6 (SEQ ID NO: 7) 
                 GGTGCTCAAGCCATCGCAGCGGCATCGTTGCTGCGAC (SEQ ID 
               
               
                   
                 NO: 32) 
               
               
                   
               
               
                 3300004774|Ga0007794_10001723_8 
                 GAGCGGTTAACAGGGTGTCGATATAGATT (SEQ ID NO: 33) 
               
               
                 (SEQ ID NO: 8) 
                   
               
               
                   
               
               
                 3300004776|Ga0007800_10001775_2 
                 GAGCGGTTAACAGGGTGTCGATATAGATT (SEQ ID NO: 33) 
               
               
                 (SEQ ID NO: 8) 
                   
               
               
                   
               
               
                 3300009004|Ga0100377_1000348_44 
                 GTAACAACAGCCATTACCCTGGCTTAGTAAGGGTGAC (SEQ ID 
               
               
                 (SEQ ID NO: 9) 
                 NO: 34) 
               
               
                   
               
               
                 3300004236|Ga0066449_1000007_83 
                 AGTAGAACCCTGTCGCTTGGGCGGTAAAGCGAAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 10) 
                 35) 
               
               
                   
               
               
                 3300009432|Ga0115005_10004282_5 
                 GATTAAGGCCCCTGTGCATTGGGGTGTAAATGCAAC (SEQ ID 
               
               
                 (SEQ ID NO: 11) 
                 NO: 3 6) 
               
               
                   
               
               
                 3300009436|Ga0115008_10017733_3 
                 GTCTAAGGCCCCTGTGCATTGGGGTGTAAATGCAAC (SEQ ID 
               
               
                 (SEQ ID NO: 12) 
                 NO: 3 7) 
               
               
                   
               
               
                 3300009436|Ga0115008_10017733_4 
                 GTCTAAGGCCCCTGTGCATTGGGGTGTAAATGCAAC (SEQ ID 
               
               
                 (SEQ ID NO: 13) 
                 NO: 3 7) 
               
               
                   
               
               
                 3300001351 JGI20153J14318_10007490_ 
                 CTTTAAGGACCCTGTACGTTGGGGTGTAAACGTAAC (SEQ ID 
               
               
                 6 (SEQ ID NO: 14) 
                 NO: 3 8) 
               
               
                   
               
               
                 3300009447|Ga0115560_1022222_2 
                 CTTTAAGGACCCTGTACGTTGGGGTGTAAACGTAAC (SEQ ID 
               
               
                 (SEQ ID NO: 15) 
                 NO: 3 8) 
               
               
                   
               
               
                 3300009505|Ga0115564_10016546_3 
                 CTTTAAGGACCCTGTACGTTGGGGTGTAAACGTAAC (SEQ ID 
               
               
                 (SEQ ID NO: 16) 
                 NO: 3 8) 
               
               
                   
               
               
                 3300020165|Ga0206125_10004811_3 
                 CTTTAAGGACCCTGTACGTTGGGGTGTAAACGTAAC (SEQ ID 
               
               
                 (SEQ ID NO: 17) 
                 NO: 3 8) 
               
               
                   
               
               
                 3300010313|Ga0116211_1004493_2 
                 GGTATCATGACCCTACGGGTGGGGGG (SEQ ID NO: 39) 
               
               
                 (SEQ ID NO: 18) 
                   
               
               
                   
               
               
                 3300009784|Ga0123357_10002363_9 
                 AGCCATCGCAGGGGCTTGGTGCTTGCGAC (SEQ ID NO: 40) 
               
               
                 (SEQ ID NO: 19) 
                   
               
               
                   
               
               
                 ADIG01000806_20 (SEQ ID NO: 20) 
                 ATTCCAAGGCGATCACAGCCGCCTAGTAGTTGTGAC (SEQ ID 
               
               
                   
                 NO: 41) 
               
               
                   
               
               
                 CXWL01128655_18 (SEQ ID NO: 21) 
                 GTTTTAGAACCCTGTTGAGTGGGCATAAACTCAAACT (SEQ ID 
               
               
                   
                 NO: 42) 
               
               
                   
               
               
                 OGCL01001770_13 (SEQ ID NO: 18) 
                 GGTATCATGACCCTACGGATGGGGGG (SEQ ID NO: 43) 
               
               
                   
               
               
                 LNAP01002847_16 (SEQ ID NO: 22) 
                 GATTCATAGCCCTGTCGGTTGGGCGGTAAACCGAAC (SEQ ID 
               
               
                   
                 NO: 44) 
               
               
                   
               
               
                 3300007533|Ga0102944_1000048_72 
                 GTCTCAATAGCGATCGGCGCCGCTTAGTAGGGTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 23) 
                 NO: 45) 
               
               
                   
               
               
                 3300007533|Ga0102944_1003721_10 
                 GGTAACAATAGCGATCGGCGCCGCTTGGTAGTGTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 24) 
                 NO: 46) 
               
               
                   
               
               
                 3300007533|Ga0102944_1003721_8 
                 GGTAACAATAGCGATCGGCGCCGCTTGGTAGTGTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 25) 
                 NO: 46) 
               
               
                   
               
               
                 APMI01033782_24 (SEQ ID NO: 26) 
                 ATCTCAATGGCCATCGTCGGGGCTTTGTACCGGCGAC (SEQ ID 
               
               
                   
                 NO: 47) 
               
               
                   
               
               
                 NZ_JQKL01000024_23 (SEQ ID NO: 48) 
                 GTTGCAATGCCTAGCTCAGAGGTTTAAAGACTGAGAC (SEQ ID 
               
               
                   
                 NO: 263) 
               
               
                   
               
               
                 WP_081908191.1 (SEQ ID NO: 49) 
                 GTTGCAATGCCTAGCTCAGAGGTTTAAAGACTGAGAC (SEQ ID 
               
               
                   
                 NO: 263) 
               
               
                   
               
               
                 GAB36148.1 (SEQ ID NO: 50) 
                 GTGTCAACGCCAGCGCGGAGGCGTCAAATCCGCGAC (SEQ ID 
               
               
                   
                 NO: 264) 
               
               
                   
               
               
                 BAFB01000202_4 (SEQ ID NO: 51) 
                 GTGTCAACGCCAGCGCGGAGGCGTCAAATCCGCGAC (SEQ ID 
               
               
                   
                 NO: 264) 
               
               
                   
               
               
                 WP_039994403.1 (SEQ ID NO: 52) 
                 GTGTCAACGCCAGCGCGGAGGCGTCAAATCCGCGAC (SEQ ID 
               
               
                   
                 NO: 264) 
               
               
                   
               
               
                 WP_013159911.1 (SEQ ID NO: 53) 
                 GTAGCAATGCCTAGCTCAGGGGCTT (SEQ ID NO: 265) 
               
               
                   
               
               
                 WP_096876841.1 (SEQ ID NO: 54) 
                 GTTACAAACCCTGCTCATTGGGTTGGTTAATGAGAC (SEQ ID 
               
               
                   
                 NO: 266) 
               
               
                   
               
               
                 WP_048895525.1 (SEQ ID NO: 55) 
                 GTGAGAATGACCAGCGCACCGGTCGAAAGGTGCGAC (SEQ ID 
               
               
                   
                 NO: 267) 
               
               
                   
               
               
                 WP_061006603.1 (SEQ ID NO: 56) 
                 GTGTCATAGCCCAGCTTGGCGGGCGAAGGCCAAGAC (SEQ ID 
               
               
                   
                 NO: 268) 
               
               
                   
               
               
                 WP_011733919.1 (SEQ ID NO: 57) 
                 GTTGACATGCGTGCTCCGCCGCTTTGTAGTGGAGAC (SEQ ID 
               
               
                   
                 NO: 269) 
               
               
                   
               
               
                 WP_018234394.1 (SEQ ID NO: 58) 
                 TTGATAATGCCCGCTCTGCGGCCTCGTAGTAGAGAC (SEQ ID 
               
               
                   
                 NO: 270) 
               
               
                   
               
               
                 3300000944|BBAY81_10000005_89 
                 CAACGCCTACAGTGGGCTTCGTACATTGTGAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 59) 
                 271) 
               
               
                   
               
               
                 LSQX01035253_23 (SEQ ID NO: 60) 
                 CAGCGGCCCACGCACGCGAGGGACGGTC (SEQ ID NO: 272) 
               
               
                   
               
               
                 3300013131|Ga0172373_10056063_2 
                 CAAGCAAGCCTTGCCGAAGAGGCTCGATCTTCGGACG (SEQ ID 
               
               
                 (SEQ ID NO: 61) 
                 NO: 273) 
               
               
                   
               
               
                 3300013136|Ga0172370_10027535_4 
                 ATGATAAGAGTTTCTCGATACTCTATAAATCGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 62) 
                 NO: 274) 
               
               
                   
               
               
                 3300013137|Ga0172375_10012175_6 
                 CAAGCAAGCCTTGCCGAAGAGGCTCGATCTTCGGAC (SEQ ID 
               
               
                 (SEQ ID NO: 63) 
                 NO: 275) 
               
               
                   
               
               
                 3300010293|Ga0116204_1010874_1 
                 GGTTGAAGCGCCCGCGCAAGGGCTTTGTACTTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 64) 
                 NO: 276) 
               
               
                   
               
               
                 3300010293|Ga0116204_1010874_2 
                 GGTTGAAGCGCCCGCGCAAGGGCTTTGTACTTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 65) 
                 NO: 276) 
               
               
                   
               
               
                 3300008255|Ga0100403_1011992_3 
                 GTCGCAATGCCAGCCGAACGGCTTGGAAGTTCGGAC (SEQ ID 
               
               
                 (SEQ ID NO: 66) 
                 NO: 277) 
               
               
                   
               
               
                 3300014155|Ga0181524_10003409_23 
                 GTGGCTACGGCATCGCGGCGCCTCGGAGATCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 67) 
                 NO: 278) 
               
               
                   
               
               
                 3300014156|Ga0181518_10000096_28 
                 GTGGCTACGGCATCGCGGCGCCTCGGAGATCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 67) 
                 NO: 278) 
               
               
                   
               
               
                 3300014158|Ga0181521_10000063_92 
                 GTGGCTACGGCATCGCGGCGCCTCGGAGATCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 67) 
                 NO: 278) 
               
               
                   
               
               
                 3300014159|Ga0181530_10000119_98 
                 GTGGCTACGGCATCGCGGCGCCTCGGAGATCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 67) 
                 NO: 278) 
               
               
                   
               
               
                 3300014201|Ga0181537_10003972_13 
                 GTCGCAGAGGAAGCTCGACGGATCGAGCGTCGAGAG (SEQ ID 
               
               
                 (SEQ ID NO: 68) 
                 NO: 279) 
               
               
                   
               
               
                 3300014201|Ga0181537_10021284_1 
                 GTCGCGATCGAAGCTCCATCGGCTGGCGATGGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 69) 
                 NO: 280) 
               
               
                   
               
               
                 3300014201|Ga0181537_10040512_3 
                 CCAGAAAGGGCAGCGCATCGCCCAGGAGAATGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 70) 
                 NO: 281) 
               
               
                   
               
               
                 3300014654|Ga0181525_10000532_4 
                 GTAGCAACGCCAGCTCGGTTGGTTCTGAGCCGAGACA (SEQ ID 
               
               
                 (SEQ ID NO: 71) 
                 NO: 282) 
               
               
                   
               
               
                 3300014657|Ga0181522_10000394_52 
                 GTGGAAACGTCAATGTCCGGCGGACGACGCTGGAAC (SEQ ID 
               
               
                 (SEQ ID NO: 72) 
                 NO: 283) 
               
               
                   
               
               
                 3300014657|Ga0181522_10000394_53 
                 GTGGAAACGTCAATGTCCGGCGGACGACGCTGGAAC (SEQ ID 
               
               
                 (SEQ ID NO: 73) 
                 NO: 283) 
               
               
                   
               
               
                 3300009175|Ga0073936_10014029_2 
                 CGCTGCAGGGCCTCAAACGACTAGACGAGGCACTGGCAAGCTACGA 
               
               
                 (SEQ ID NO: 74) 
                 CAAGG (SEQ ID NO: 284) 
               
               
                   
               
               
                 3300015360|Ga0163144_10020017_5 
                 CCAACAACGGCTGCTGAGCGCCTT (SEQ ID NO: 285) 
               
               
                 (SEQ ID NO: 75) 
                   
               
               
                   
               
               
                 3300015360|Ga0163144_10020017_4 
                 CCAACAACGGCTGCTGAGCGCCTT (SEQ ID NO: 285) 
               
               
                 (SEQ ID NO: 76) 
                   
               
               
                   
               
               
                 3300015360|Ga0163144_10033243_8 
                 GGCTGCTGAGCGCCTTACAAGCTCAGAC (SEQ ID NO: 286) 
               
               
                 (SEQ ID NO: 77) 
                   
               
               
                   
               
               
                 3300015360|Ga0163144_10033243_7 
                 GGCTGCTGAGCGCCTTACAAGCTCAGAC (SEQ ID NO: 286) 
               
               
                 (SEQ ID NO: 78) 
                   
               
               
                   
               
               
                 3300015360|Ga0163144_10062707_6 
                 GTAACAACCCCTAGCGCAAGAGGGAAAGCTTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 79) 
                 NO: 287) 
               
               
                   
               
               
                 3300015360|Ga0163144_10062707_6 
                 GTAACAACCCCTAGCGCAAGAGGGAAAGCTTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 80) 
                 NO: 287) 
               
               
                   
               
               
                 3300020057|Ga0163151_10006104_16 
                 CCAACAGCGGCTGCTGAACGCCTTACAAGTTCAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 75) 
                 NO: 288) 
               
               
                   
               
               
                 3300020186|Ga0163153_10017638_7 
                 CTCACAGTGCCTGCGCAGCGGCTTCGTAGCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 81) 
                 NO: 289) 
               
               
                   
               
               
                 3300020195|Ga0163150_10003396_14 
                 CTCACAGTGCCTGCGCAGCGGCTTCGTAGCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 82) 
                 NO: 289) 
               
               
                   
               
               
                 3300020203|Ga0163148_10001247_2 
                 GTAACAACCCCTAGCGCAAGAGGGAAAGCTTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 83) 
                 NO: 287) 
               
               
                   
               
               
                 3300020203|Ga0163148_10001247_2 
                 GTAACAACCCCTAGCGCAAGAGGGAAAGCTTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 84) 
                 NO: 287) 
               
               
                   
               
               
                 3300020213|Ga0163152_10009495_14 
                 GTAACAACCCCTAGCGCAAGAGGGAAAGCTTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 85) 
                 NO: 287) 
               
               
                   
               
               
                 3300020213|Ga0163152_10009495_14 
                 GTAACAACCCCTAGCGCAAGAGGGAAAGCTTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 86) 
                 NO: 287) 
               
               
                   
               
               
                 3300020219|Ga0163146_10006198_18 
                 CCAACAGCGGCTGCTGAACGCCTTACAAGTTCAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 75) 
                 NO: 288) 
               
               
                   
               
               
                 3300020596|Ga0163149_10010333_13 
                 CCAACAACGGCTGCTGAACGCCTTACAAGTTCAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 87) 
                 NO: 290) 
               
               
                   
               
               
                 3300020596|Ga0163149_10010333_12 
                 CCAACAACGGCTGCTGAACGCCTTACAAGTTCAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 88) 
                 NO: 290) 
               
               
                   
               
               
                 3300004174|Ga0066406_1000030_21 
                 GTTGCAATGCCTGCTCATAGGCTTGGTTTATGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 89) 
                 NO: 291) 
               
               
                   
               
               
                 3300004200|Ga0066422_1000628_7 
                 GTTGCAATGCCTGCTCATAGGCTTGGTTTATGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 89) 
                 NO: 291) 
               
               
                   
               
               
                 3300004205|Ga0066415_1000057_23 
                 GTTGCAATGCCTGCTCATAGGCTTGGTTTATGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 89) 
                 NO: 291) 
               
               
                   
               
               
                 3300004565|Ga0066503_104695_4 
                 GTTGCAATGCCTGCTCATAGGCTTGGTTTATGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 89) 
                 NO: 291) 
               
               
                   
               
               
                 3300009686|Ga0123338_10029047_2 
                 GTAGCAATACCCTAGCTCGAGGGGGGTTTGTCGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 90) 
                 NO: 292) 
               
               
                   
               
               
                 3300001242|C687J13896_1000006_134 
                 GTTTCAGTATCCTGCTCAGAGGAGTCGTTTCTGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 91) 
                 NO: 293) 
               
               
                   
               
               
                 3300005236|Ga0066636_10020712_3 
                 GTCGCAATGCCAGCCGAACGGCTTGGAAGTTCGGAC (SEQ ID 
               
               
                 (SEQ ID NO: 92) 
                 NO: 277) 
               
               
                   
               
               
                 3300014208|Ga0172379_10007070_15 
                 GCGACGACAACGGCAGCTCATCGCCACGAAAGATGAGAC (SEQ 
               
               
                 (SEQ ID NO: 93) 
                 ID NO: 294) 
               
               
                   
               
               
                 3300014208|Ga0172379_10014650_2 
                 GTGCAGGGCTGTCGAACCTGCGA (SEQ ID NO: 295) 
               
               
                 (SEQ ID NO: 94) 
                   
               
               
                   
               
               
                 3300014613|Ga0180008_1000021_8 
                 GCTGGGATGTTTAGTGATC (SEQ ID NO: 296) 
               
               
                 (SEQ ID NO: 95) 
                   
               
               
                   
               
               
                 3300014613|Ga0180008_1000021_9 
                 GCTGGGATGTTTAGTGATC (SEQ ID NO: 296) 
               
               
                 (SEQ ID NO: 96) 
                   
               
               
                   
               
               
                 3300014656|Ga0180007_10000195_44 
                 GCTGGGAGGTTTAGTGATCCCAGAC (SEQ ID NO: 297) 
               
               
                 (SEQ ID NO: 95) 
                   
               
               
                   
               
               
                 3300014656|Ga0180007_10000195_48 
                 GCTGGGAGGTTTAGTGATCCCAGAC (SEQ ID NO: 297) 
               
               
                 (SEQ ID NO: 96) 
                   
               
               
                   
               
               
                 3300014656|Ga0180007_10004731_7 
                 GTCACAATGCCTGCGCAGAGGCTTTGTTTCTGCGACG (SEQ ID 
               
               
                 (SEQ ID NO: 97) 
                 NO: 298) 
               
               
                   
               
               
                 3300014656|Ga0180007_10004731_5 
                 GTCACAATGCCTGCGCAGAGGCTTTGTTTCTGCGACG (SEQ ID 
               
               
                 (SEQ ID NO: 98) 
                 NO: 298) 
               
               
                   
               
               
                 3300015370|Ga0180009_10002661_7 
                 GTATCAATGCCTGCTCAAGGGCTTTGTGCTTGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 99) 
                 NO: 299) 
               
               
                   
               
               
                 3300009760|Ga0116131_1003961_2 
                 CTCGCAATGCCAGCCCAGAGGCGGATGTTCTGGGAC (SEQ ID 
               
               
                 (SEQ ID NO: 100) 
                 NO: 300) 
               
               
                   
               
               
                 3300018019|Ga0187874_10017489_1 
                 CTTTCAAGACGAGCGGAAGCGTCTGCTTCTTCCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 101) 
                 NO: 301) 
               
               
                   
               
               
                 3300018025|Ga0187885_10005575_2 
                 ATCGAAGAGCCTGCTCAGGGGCTTTGTTCTTGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 102) 
                 NO: 302) 
               
               
                   
               
               
                 3300018025|Ga0187885_10005575_1 
                 ATCGAAGAGCCTGCTCAGGGGCTTTGTTCTTGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 103) 
                 NO: 302) 
               
               
                   
               
               
                 3300018057|Ga0187858_10035455_2 
                 CTTTCAAGACGAGCGGAAGCGTCTGCTTCTTCCG (SEQ ID NO: 
               
               
                 (SEQ ID NO: 104) 
                 303) 
               
               
                   
               
               
                 3300012183|Ga0136624_1011435_1 
                 TAAGTGTCAGTGCCTGCGCACCGG (SEQ ID NO: 304) 
               
               
                 (SEQ ID NO: 105) 
                   
               
               
                   
               
               
                 3300012682|Ga0136611_10000100_4 
                 CAAACAATGCCCGCGCAGTGGGCTTCGTCACTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 106) 
                 NO: 305) 
               
               
                   
               
               
                 3300013127|Ga0172365_10004082_5 
                 GTAGTAACGCCCGCGAACAGGCTTCGTTTGTTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 107) 
                 NO: 306) 
               
               
                   
               
               
                 3300013127|Ga0172365_10004082_3 
                 GTAGTAACGCCCGCGAACAGGCTTCGTTTGTTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 108) 
                 NO: 306) 
               
               
                   
               
               
                 3300013127|Ga0172365_10033732_1 
                 CGTTGCAAGGGCTGCGCGACACCCTGGAAGTCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 109) 
                 NO: 307) 
               
               
                   
               
               
                 3300013128|Ga0172366_10016188_4 
                 GTAGTAACGCCCGCGAACAGGCTTCGTTTGTTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 107) 
                 NO: 306) 
               
               
                   
               
               
                 3300013128 Ga0172366_10018111_5 
                 GTCGCAATGGGGCGCTCACCCCCCTTGTAAGTGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 110) 
                 NO: 308) 
               
               
                   
               
               
                 3300013129|Ga0172364_10001281_26 
                 GTGGCAAAGGCATCGAATCGCCTGAGAAGATTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 111) 
                 NO: 309) 
               
               
                   
               
               
                 3300013129|Ga0172364_10017363_4 
                 AACGCCTGCGAACAGGCTTCGTTTGTTCGAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 107) 
                 310) 
               
               
                   
               
               
                 3300013129|Ga0172364_10018773_2 
                 GTCGCAATGGGGCGCTCACCCCCTTTGTAAGTGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 112) 
                 NO: 311) 
               
               
                   
               
               
                 3300013129|Ga0172364_10045136_2 
                 GTTGCAAGGGCTGCGCGACACCCTGGAAGTCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 113) 
                 NO: 312) 
               
               
                   
               
               
                 3300013130|Ga0172363_10000480_22 
                 GTGGCAAAGGCATCGAATCGCCTGAGAAGATTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 111) 
                 NO: 309) 
               
               
                   
               
               
                 3300013130|Ga0172363_10009486_8 
                 AACGCCTGCGAACAGGCTTCGTTTGTTCGAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 114) 
                 310) 
               
               
                   
               
               
                 3300013130|Ga0172363_10014785_2 
                 GGGTGGCAGTGCCTGCTCAGAGGCTTAGTATCTGTGACA (SEQ 
               
               
                 (SEQ ID NO: 115) 
                 ID NO: 313) 
               
               
                   
               
               
                 3300013133|Ga0172362_10012573_3 
                 AACGCCTGCGAACAGGCTTCGTTTGTTCGAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 107) 
                 310) 
               
               
                   
               
               
                 3300013133|Ga0172362_10022806_8 
                 TGTGGCAGTGCCTGCTCAGAGGCTTAGTATCTGTGACA (SEQ ID 
               
               
                 (SEQ ID NO: 115) 
                 NO: 314) 
               
               
                   
               
               
                 3300013133|Ga0172362_10025871_2 
                 GTTGCAAGGGTTGCGCGACACCCTGGAAGTCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 113) 
                 NO: 315) 
               
               
                   
               
               
                 3300010155|Ga0098047_10009758_2 
                 GTGCAAATGCCCGCACAGAGGCTTAGTGTCTGTGAC (SEQ ID 
               
               
                 (SEQ ID NO: 116) 
                 NO: 316) 
               
               
                   
               
               
                 3300006805|Ga0075464_10026824_2 
                 GTCACAACGCCCGCGCAGGGGCTTGGTATCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 117) 
                 NO: 317) 
               
               
                   
               
               
                 3300006805|Ga0075464_10026824_2 
                 GTCACAACGCCCGCGCAGGGGCTTGGTATCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 118) 
                 NO: 317) 
               
               
                   
               
               
                 3300009149|Ga0114918_10020022_2 
                 CTTTCAAAGCTTGCTCGTTAGCTTTATGAACGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 119) 
                 NO: 318) 
               
               
                   
               
               
                 3300006083|Ga0081762_1007854_6 
                 GTTTGAAAGCAGCTATAGAGGGCAGAAAC (SEQ ID NO: 319) 
               
               
                 (SEQ ID NO: 120) 
                   
               
               
                   
               
               
                 3300010354|Ga0129333_10000304_8 
                 GCAAGGGCTGCTCAGGGCCCTGGAATCTGAGAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 121) 
                 320) 
               
               
                   
               
               
                 3300010354|Ga0129333_10000304_10 
                 GCAAGGGCTGCTCAGGGCCCTGGAATCTGAGAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 122) 
                 320) 
               
               
                   
               
               
                 3300009507|Ga0115572_10029017_2 
                 ATTTAATGACCCTGCGTGTTGGGGTGTGAACACGAC (SEQ ID 
               
               
                 (SEQ ID NO: 123) 
                 NO: 321) 
               
               
                   
               
               
                 3300017963|Ga0180437_10000100_151 
                 CTTACAATACCTGCGAGACGGTTTAGAAGTCTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 124) 
                 NO: 322) 
               
               
                   
               
               
                 3300017963|Ga0180437_10000153_25 
                 CCTTCAATCCCTGCGAGACGGGTTAGAAGTCTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 125) 
                 NO: 323) 
               
               
                   
               
               
                 3300017963|Ga0180437_10000488_78 
                 GTAACAACACCAGTCCAAAGGTTTATGATTTGGAAC (SEQ ID 
               
               
                 (SEQ ID NO: 126) 
                 NO: 324) 
               
               
                   
               
               
                 3300017963|Ga0180437_10000692_13 
                 CTCGCGGTCCCATCGGAACGGGTTGTGGTTCCGACA (SEQ ID 
               
               
                 (SEQ ID NO: 127) 
                 NO: 325) 
               
               
                   
               
               
                 3300017963|Ga0180437_10006965_20 
                 GTCTCAACGCCTACTCAGGGGCTTTGT (SEQ ID NO: 326) 
               
               
                 (SEQ ID NO: 128) 
                   
               
               
                   
               
               
                 3300017963|Ga0180437_10006965_20 
                 GTCTCAACGCCTACTCAGGGGCTTTGT (SEQ ID NO: 326) 
               
               
                 (SEQ ID NO: 129) 
                   
               
               
                   
               
               
                 3300017963|Ga0180437_10073069_2 
                 CTTGCAACGGCAGCGTACCGCCTTCAAGTGTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 130) 
                 NO: 327) 
               
               
                   
               
               
                 3300017971|Ga0180438_10000090_91 
                 CCTTCAATCCCTGCGAGACGGGTTAGAAGTCTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 125) 
                 NO: 323) 
               
               
                   
               
               
                 3300017971|Ga0180438_10000124_114 
                 CTCGCGGTCCCATCGGAACGGGTTGTGGTTCCGACA (SEQ ID 
               
               
                 (SEQ ID NO: 127) 
                 NO: 325) 
               
               
                   
               
               
                 3300017971|Ga0180438_10000195_144 
                 CTTACAATACCTGCGAGACGGTTTAGAAGTCTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 124) 
                 NO: 322) 
               
               
                   
               
               
                 3300017971|Ga0180438_10013386_7 
                 GTAACAACACCAGTCCAAAGGTTTATGATTTGGAAC (SEQ ID 
               
               
                 (SEQ ID NO: 126) 
                 NO: 324) 
               
               
                   
               
               
                 3300017971|Ga0180438_10021273_1 
                 GTCTCAACGCCTACTCAGGGGCTTTGT (SEQ ID NO: 326) 
               
               
                 (SEQ ID NO: 131) 
                   
               
               
                   
               
               
                 3300017971|Ga0180438_10044179_5 
                 CCTTGCAACGGCAGCGTACCGCCTTCAAGTGTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 132) 
                 NO: 328) 
               
               
                   
               
               
                 3300017971|Ga0180438_10056790_2 
                 CCGGGAACAGCCGCGCAGGGGCTTGGTGCCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 133) 
                 NO: 329) 
               
               
                   
               
               
                 3300017971|Ga0180438_10072596_2 
                 CGTCGCAACGCCTGCGGAGAGGCCTTGTTTCTCCGACGG (SEQ 
               
               
                 (SEQ ID NO: 134) 
                 ID NO: 330) 
               
               
                   
               
               
                 3300017987|Ga0180431_10022214_3 
                 GTTTCAGACCCATCGCAAGGGGTTATAGCTTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 135) 
                 NO: 331) 
               
               
                   
               
               
                 3300017987|Ga0180431_10041976_5 
                 GTCGCAACGCCTGCGGAGAGGCCTTGTTTCTCCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 136) 
                 NO: 332) 
               
               
                   
               
               
                 3300017989|Ga0180432_10002388_5 
                 GTTTCAGACCCATCGCAAGGGGTTATAGCTTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 135) 
                 NO: 331) 
               
               
                   
               
               
                 3300017989|Ga0180432_10021155_3 
                 GTTGCAAAGCCATCTCCAGGGTTTGGTGCTGGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 137) 
                 NO: 333) 
               
               
                   
               
               
                 3300017989|Ga0180432_10021155_5 
                 GTTGCAAAGCCATCTCCAGGGTTTGGTGCTGGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 138) 
                 NO: 333) 
               
               
                   
               
               
                 3300017989|Ga0180432_10043261_1 
                 GTTGGAATGCCTGTGGAAAGGCTTTGTATTTCCAAC (SEQ ID 
               
               
                 (SEQ ID NO: 139) 
                 NO: 334) 
               
               
                   
               
               
                 3300017989|Ga0180432_10045094_6 
                 AGCAATGCGAGCGCAGACGCTTCGTATCTGCGAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 140) 
                 335) 
               
               
                   
               
               
                 3300017991|Ga0180434_10002646_1 
                 GTTTCAGACCCATCGCAAGGGGTTATAGCTTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 135) 
                 NO: 331) 
               
               
                   
               
               
                 3300017991|Ga0180434_10013735_9 
                 GTCACAACGCCTGCGCAAGGGCTTTGTTATTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 141) 
                 NO: 336) 
               
               
                   
               
               
                 3300017992|Ga0180435_10018121_11 
                 CTTCCAATACCTGCGAGACGGTTTAGAAGTCTCGACG (SEQ ID 
               
               
                 (SEQ ID NO: 142) 
                 NO: 337) 
               
               
                   
               
               
                 3300018065|Ga0180430_10011859_2 
                 GGAGCAATGCCTGCACGAGGGCTTTGTGCTCGTGAC (SEQ ID 
               
               
                 (SEQ ID NO: 143) 
                 NO: 338) 
               
               
                   
               
               
                 3300018065|Ga0180430_10038979_3 
                 GTCGCAACGCCTGCGCGGAGGCTTTGTTTCCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 144) 
                 NO: 339) 
               
               
                   
               
               
                 3300018080|Ga0180433_10006034_17 
                 ATGGAAATGCCATTACAAAGGTTTAGGATTTGTAAC (SEQ ID 
               
               
                 (SEQ ID NO: 145) 
                 NO: 340) 
               
               
                   
               
               
                 3300018080|Ga0180433_10006034_18 
                 ATGGAAATGCCATTACAAAGGTTTAGGATTTGTAAC (SEQ ID 
               
               
                 (SEQ ID NO: 146) 
                 NO: 340) 
               
               
                   
               
               
                 3300018080|Ga0180433_10012134_6 
                 TGTCGCAAAGCCATCTCCAAGGCTTGGTG (SEQ ID NO: 341) 
               
               
                 (SEQ ID NO: 147) 
                   
               
               
                   
               
               
                 3300018080|Ga0180433_10012134_6 
                 TGTCGCAAAGCCATCTCCAAGGCTTGGTG (SEQ ID NO: 341) 
               
               
                 (SEQ ID NO: 148) 
                   
               
               
                   
               
               
                 3300018080|Ga0180433_10020043_6 
                 CTCGCAATCGAAGCTCCGCCCGTTGTAGGCGGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 149) 
                 NO: 342) 
               
               
                   
               
               
                 3300018080|Ga0180433_10021337_5 
                 GTCACAACGCCTGCGCAAGGGCTTTGTTATTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 150) 
                 NO: 336) 
               
               
                   
               
               
                 3300018080|Ga0180433_10021840_7 
                 TGGAAGAGCCATCGCAATGGCTTCGGATTGCGAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 151) 
                 343) 
               
               
                   
               
               
                 3300018080|Ga0180433_10021840_7 
                 TGGAAGAGCCATCGCAATGGCTTCGGATTGCGAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 152) 
                 343) 
               
               
                   
               
               
                 3300001256|JGI12210J13797_10495608_ 
                 CACGAAAAGGCAGCTCGATGCCTTACAAATCGAGAC (SEQ ID 
               
               
                 9 (SEQ ID NO: 153) 
                 NO: 344) 
               
               
                   
               
               
                 3300001256|JGI12210J13797_10495610_ 
                 CACGAAAAGGCAGCTCGATGCCTTACAAATCGAGAC (SEQ ID 
               
               
                 14 (SEQ ID NO: 153) 
                 NO: 344) 
               
               
                   
               
               
                 3300005917|Ga0075115_10002831_4 
                 AGAAATGGTTGTGAAATGCCTTTAAAATTTCAAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 154) 
                 345) 
               
               
                   
               
               
                 3300005918|Ga0075116_10002890_7 
                 ACAGAAATGGTAGTGGAATGCCTTTAAAATT (SEQ ID NO: 
               
               
                 (SEQ ID NO: 155) 
                 346) 
               
               
                   
               
               
                 3300011414|Ga0137442_1000121_10 
                 GCCACAGCACCTGCTCGAACGGTTCGAGTTCGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 156) 
                 NO: 347) 
               
               
                   
               
               
                 3300011431|Ga0137438_1001223_2 
                 GCCACAGCACCTGCTCGAACGGTTCGAGTTCGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 156) 
                 NO: 347) 
               
               
                   
               
               
                 3300011441|Ga0137452_1000071_9 
                 CTGAAAACGCCAGCGCGAAGGCTTCATATTCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 157) 
                 NO: 348) 
               
               
                   
               
               
                 3300006855|Ga0079044_1002244_2 
                 GTGCAAGAGCCTGCGCCGAGGCGTCGTATCGGCGACA (SEQ ID 
               
               
                 (SEQ ID NO: 158) 
                 NO: 349) 
               
               
                   
               
               
                 3300006855|Ga0079044_1002244_2 
                 GTGCAAGAGCCTGCGCCGAGGCGTCGTATCGGCGACA (SEQ ID 
               
               
                 (SEQ ID NO: 159) 
                 NO: 349) 
               
               
                   
               
               
                 3300009503|Ga0123519_10000481_19 
                 GTGGAAAGGGTATCTCTGGACCTTACAATCAGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 160) 
                 NO: 350) 
               
               
                   
               
               
                 3300009503|Ga0123519_10000481_22 
                 GTGGAAAGGGTATCTCTGGACCTTACAATCAGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 161) 
                 NO: 350) 
               
               
                   
               
               
                 3300006865|Ga0073934_10032691_1 
                 GCCGCAACGCCTGTGGAAGGGC (SEQ ID NO: 351) 
               
               
                 (SEQ ID NO: 162) 
                   
               
               
                   
               
               
                 3300001340|JGI20133J14441_1002607 
                 GGTGCAGCGGTTGCTCAGCACCGTAGAAGCTGAGAG (SEQ ID 
               
               
                 _2 (SEQ ID NO: 163) 
                 NO: 352) 
               
               
                   
               
               
                 3300009784|Ga0123357_10000018_10 
                 CCCGTGCCCGTCTCCGTCTCC (SEQ ID NO: 353) 
               
               
                 5 (SEQ ID NO: 164) 
                   
               
               
                   
               
               
                 3300009784|Ga0123357_10000074_42 
                 GATCGCGACGGCGACGGTATCC (SEQ ID NO: 354) 
               
               
                 (SEQ ID NO: 165) 
                   
               
               
                   
               
               
                 3300009784|Ga0123357_10000076_32 
                 GGCGTCCGCCAGCGTCGGGGCAACCACACCGACGAC (SEQ ID 
               
               
                 (SEQ ID NO: 166) 
                 NO: 355) 
               
               
                   
               
               
                 BBPF01004549_6 (SEQ ID NO: 167) 
                 GTTGCAGTGCCCAGCTCAGGGGCTTGATAACTGAGAC (SEQ ID 
               
               
                   
                 NO: 356) 
               
               
                   
               
               
                 BBPG01001333_4(SEQ ID NO:167) 
                 GTTGCAGTGCCCAGCTCAGGGGCTTGATAACTGAGAC (SEQ ID 
               
               
                   
                 NO: 356) 
               
               
                   
               
               
                 OGZV01009429_1 (SEQ ID NO: 168) 
                 TAGTGAGTTTAGCACATTTCTAAAAC (SEQ ID NO: 357) 
               
               
                   
               
               
                 OKWZ01000119_10 (SEQ ID NO: 169) 
                 GTTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 358) 
               
               
                   
               
               
                 ODGR01000476_16 (SEQ ID NO: 170) 
                 TTAAGTAGTAGTGAGTTTAGCATATTTCTAAAACG (SEQ ID 
               
               
                   
                 NO: 359) 
               
               
                   
               
               
                 ODIG01000268_14 (SEQ ID NO: 169) 
                 GTTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 358) 
               
               
                   
               
               
                 ODIP01002140_2 (SEQ ID NO: 171) 
                 TAAGTAATAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID NO: 
               
               
                   
                 360) 
               
               
                   
               
               
                 ODIW01000227_18 (SEQ ID NO: 171) 
                 TTAAGTAATAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID NO: 
               
               
                   
                 361) 
               
               
                   
               
               
                 ODJA01000260_38 (SEQ ID NO: 169) 
                 GTTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 358) 
               
               
                   
               
               
                 ODJP01000229_55 (SEQ ID NO: 169) 
                 GTTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 358) 
               
               
                   
               
               
                 ODKZ01007116_1 (SEQ ID NO: 172) 
                 TTAAGTAGTAGTGAGTTTAGCATATTTCTAAAACG (SEQ ID 
               
               
                   
                 NO: 359) 
               
               
                   
               
               
                 ODMO01000523_12 (SEQ ID NO: 169) 
                 GTTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 358) 
               
               
                   
               
               
                 ODTN01000195_35 (SEQ ID NO: 169) 
                 GTTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 358) 
               
               
                   
               
               
                 ODTP01000194_18 (SEQ ID NO: 172) 
                 GGTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 362) 
               
               
                   
               
               
                 ODWI01002981_3 (SEQ ID NO: 169) 
                 GTTTAAGTAGTAGTGAGTTTAGCACATTTCTA (SEQ ID NO: 
               
               
                   
                 363) 
               
               
                   
               
               
                 ODZZ01005262_2 (SEQ ID NO: 169) 
                 GTTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 358) 
               
               
                   
               
               
                 OEED01000500_25 (SEQ ID NO: 173) 
                 TAAGTAATAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID NO: 
               
               
                   
                 360) 
               
               
                   
               
               
                 OEFT01000529_3 (SEQ ID NO: 169) 
                 GTTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 358) 
               
               
                   
               
               
                 LAZR01002400_15 (SEQ ID NO: 174) 
                 GTAGCAATGGCAGCGCATCGCCTTTTAAGATGCGAC (SEQ ID 
               
               
                   
                 NO: 364) 
               
               
                   
               
               
                 LAZR01002400_19 (SEQ ID NO: 175) 
                 GTAGCAATGGCAGCGCATCGCCTTTTAAGATGCGAC (SEQ ID 
               
               
                   
                 NO: 364) 
               
               
                   
               
               
                 FLSK01003024_2 (SEQ ID NO: 169) 
                 GTTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 358) 
               
               
                   
               
               
                 OFLM01000072_9 (SEQ ID NO: 176) 
                 TAATGAGTTTAGCATATCTCTAAAAC (SEQ ID NO: 365) 
               
               
                   
               
               
                 OFLO01000090_50 (SEQ ID NO: 176) 
                 TGAGTTTAGCATATCTCTAAAAC (SEQ ID NO: 366) 
               
               
                   
               
               
                 OFLU01000140_22 (SEQ ID NO: 177) 
                 GGTTAAGTAGTAGTGAGTTTAGCATATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 367) 
               
               
                   
               
               
                 OFLV01000230_3 (SEQ ID NO: 177) 
                 GGTTAAGTAGTAGTGAGTTTAGCATATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 367) 
               
               
                   
               
               
                 OGCY01000078_30 (SEQ ID NO: 178) 
                 GGTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 362) 
               
               
                   
               
               
                 OGJO01000473_2 (SEQ ID NO: 169) 
                 GTTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 358) 
               
               
                   
               
               
                 OGJT01000109_37 (SEQ ID NO: 179) 
                 GGTTAAATAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 368) 
               
               
                   
               
               
                 OGJZ01005194_5 (SEQ ID NO: 180) 
                 GGTTAAGTAGTAGTGAGTTTAGCATATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 367) 
               
               
                   
               
               
                 OGKO01001669_8 (SEQ ID NO: 181) 
                 GGTTAAGTAGTAGTGAGTTTAGCACATCTCTAAAAC (SEQ ID 
               
               
                   
                 NO: 362) 
               
               
                   
               
               
                 OFCI01000292_37 (SEQ ID NO: 182) 
                 GTAACAGAGGCTGCTCAATGCCTTTGAAATTGAGAC (SEQ ID 
               
               
                   
                 NO: 369) 
               
               
                   
               
               
                 3300006048|Ga0075363_100000001_25 
                 GTAACAATCCCAGTGCAACGGGTTAGTAGTTGCAAC (SEQ ID 
               
               
                 (SEQ ID NO: 183) 
                 NO: 370) 
               
               
                   
               
               
                 3300006048|Ga0075363_100000001_20 
                 GTAACAATCCCAGTGCAACGGGTTAGTAGTTGCAAC (SEQ ID 
               
               
                 (SEQ ID NO: 184) 
                 NO: 370) 
               
               
                   
               
               
                 3300006048|Ga0075363_100000020_49 
                 GTGTGGAGGCAGCTCGGTGCCGATGGAAACTGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 185) 
                 NO: 371) 
               
               
                   
               
               
                 3300006178|Ga0075367_10000108__6 
                 GTAACAATCCCAGTGCAACGGGTTAGTAGTTGCAAC (SEQ ID 
               
               
                 (SEQ ID NO: 183) 
                 NO: 370) 
               
               
                   
               
               
                 3300006178|Ga0075367_10000108_6 
                 GTAACAATCCCAGTGCAACGGGTTAGTAGTTGCAAC (SEQ ID 
               
               
                 (SEQ ID NO: 184) 
                 NO: 370) 
               
               
                   
               
               
                 3300006195|Ga0075366_10000160_13 
                 GTAACAATCCCAGTGCAACGGGTTAGTAGTTGCAAC (SEQ ID 
               
               
                 (SEQ ID NO: 183) 
                 NO: 370) 
               
               
                   
               
               
                 3300009500|Ga0116229_10010095_9 
                 CTTGCAATGGCTGCGCAGGGCCTTGGACGCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 186) 
                 NO: 372) 
               
               
                   
               
               
                 3300009701|Ga0116228_10018148_5 
                 TCGAATTCGGTTGACGCT (SEQ ID NO: 373) 
               
               
                 (SEQ ID NO: 187) 
                   
               
               
                   
               
               
                 3300005577|Ga0068857_100000008_197 
                 GTTGGCAATAGAAGCTAACCTCTATAAGCGTTAGACC (SEQ ID 
               
               
                 (SEQ ID NO: 188) 
                 NO: 374) 
               
               
                   
               
               
                 3300005338|Ga0068868_100030384_5 
                 GTGGAGAGGCCAGCGCAGGGGCTTTGTGCCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 189) 
                 NO: 375) 
               
               
                   
               
               
                 3300005841|Ga0068863_100041042_2 
                 GTTGAAAACCCCATCGATTCGGGGTAGTG (SEQ ID NO: 376) 
               
               
                 (SEQ ID NO: 190) 
                   
               
               
                   
               
               
                 3300013306|Ga0163162_10000022_153 
                 CTCGCAAGCGTTGCTCGACACGCTAGGTGTCGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 191) 
                 NO: 377) 
               
               
                   
               
               
                 3300009148|Ga0105243_10000126_60 
                 TCGTCCTGCAGCGTGATCCCGCC (SEQ ID NO: 378) 
               
               
                 (SEQ ID NO: 192) 
                   
               
               
                   
               
               
                 3300006846|Ga0075430_100000057_67 
                 GCCGTCGAAATGCCTGCTCGGGGGCTTCGTACCTGAGAC (SEQ 
               
               
                 (SEQ ID NO: 193) 
                 ID NO: 379) 
               
               
                   
               
               
                 3300006853|Ga0075420_100000070_3 
                 GCCGTCGAAATGCCTGCTCGGGGGCTTCGTACCTGAGAC (SEQ 
               
               
                 (SEQ ID NO: 193) 
                 ID NO: 379) 
               
               
                   
               
               
                 3300006854|Ga0075425_100000037_57 
                 GTGTGGAGGCAGCTCGGTGCCGATGGAAACTGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 185) 
                 NO: 371) 
               
               
                   
               
               
                 3300006903|Ga0075426_10000611_28 
                 AAGAGCATCCCGGGCGCGAA (SEQ ID NO: 380) 
               
               
                 (SEQ ID NO: 194) 
                   
               
               
                   
               
               
                 3300006914|Ga0075436_100000782_9 
                 AAGAGCATCCCGGGCGCGAA (SEQ ID NO: 380) 
               
               
                 (SEQ ID NO: 194) 
                   
               
               
                   
               
               
                 3300007076|Ga0075435_100000061_47 
                 AAGAGCATCCCGGGCGCGAA (SEQ ID NO: 380) 
               
               
                 (SEQ ID NO: 194) 
                   
               
               
                   
               
               
                 3300007076|Ga0075435_100000750_29 
                 GTGTGGAGGCAGCTCGGTGCCGATGGAAACTGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 185) 
                 NO: 371) 
               
               
                   
               
               
                 3300009100|Ga0075418_10076301_2 
                 GTAGGAACCCCTAGTGTCCTGGGTGGAGAGGACAAC (SEQ ID 
               
               
                 (SEQ ID NO: 195) 
                 NO: 381) 
               
               
                   
               
               
                 3300009100|Ga0075418_10076301_2 
                 GTAGGAACCCCTAGTGTCCTGGGTGGAGAGGACAAC (SEQ ID 
               
               
                 (SEQ ID NO: 196) 
                 NO: 381) 
               
               
                   
               
               
                 3300009156|Ga0111538_10081463_8 
                 GCGCGGGGGCTTGGTTCCTGCGAC (SEQ ID NO: 382) 
               
               
                 (SEQ ID NO: 197) 
                   
               
               
                   
               
               
                 3300005548|Ga0070665_100000073_173 
                 GAAACAAAGCGTGCTCTGCCGCTTGGAAGCAGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 198) 
                 NO: 383) 
               
               
                   
               
               
                 OBLM01000011_1 (SEQ ID NO: 199) 
                 CGTGACGATGGTTGCTCG (SEQ ID NO: 384) 
               
               
                   
               
               
                 OCTA010000646_37(SEQ ID NO:200) 
                 AATCCCTGCTCAAGAGGGTGTGTCTTGAGAC (SEQ ID NO: 
               
               
                   
                 385) 
               
               
                   
               
               
                 ODAK010001378_33 (SEQ ID NO: 201) 
                 CTCGCAATCGTTGCTGGACGGACTTCTCGTTCAGAC (SEQ ID 
               
               
                   
                 NO: 386) 
               
               
                   
               
               
                 ODAK010029943_5 (SEQ ID NO: 202) 
                 GTCGAAATGCCCGCTCAGCGGCTTAGTTGCTGAGAC (SEQ ID 
               
               
                   
                 NO: 387) 
               
               
                   
               
               
                 ODAK010029943_6 (SEQ ID NO: 203) 
                 GTCGAAATGCCCGCTCAGCGGCTTAGTTGCTGAGAC (SEQ ID 
               
               
                   
                 NO: 387) 
               
               
                   
               
               
                 3300005602|Ga0070762_10000001_34 
                 GTCGAGATCAGGCTCCATGAGATCGACCATGGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 204) 
                 NO: 388) 
               
               
                   
               
               
                 3300005602|Ga0070762_10000001_32 
                 GTCGAGATCAGGCTCCATGAGATCGACCATGGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 205) 
                 NO: 388) 
               
               
                   
               
               
                 3300006796|Ga0066665_10000988_15 
                 GGTGACAAAGCCCTGTGCAGCGGGCTC7V\AGCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 206) 
                 NO: 389) 
               
               
                   
               
               
                 3300018429|Ga0190272_10000030_113 
                 GTCGCAACGCCTGCGTCGGGGCCTCGTGCCGACGAC (SEQ ID 
               
               
                 (SEQ ID NO: 207) 
                 NO: 390) 
               
               
                   
               
               
                 3300018432|Ga0190275_10000082_154 
                 GCAATGGCTGCTCAGCGCCCTTGAAGCTGAGAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 208) 
                 391) 
               
               
                   
               
               
                 3300018481|Ga0190271_10027355_3 
                 AGCCTGCGCGGTGGCTGAGGACCGCGAC (SEQ ID NO: 392) 
               
               
                 (SEQ ID NO: 209) 
                   
               
               
                   
               
               
                 3300019874 Ga0193744_1000265_21 
                 GTGTGGAGGCTGCTCAAGGCCGATGGAACTTGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 210) 
                 NO: 393) 
               
               
                   
               
               
                 33000200211Ga0193726_1013919_1 
                 GGTGGCACGAGTTGCTCGGCGCTCTACGAGCCGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 211) 
                 NO: 394) 
               
               
                   
               
               
                 33000200211Ga0193726_1013919_1 
                 GGTGGCACGAGTTGCTCGGCGCTCTACGAGCCGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 212) 
                 NO: 394) 
               
               
                   
               
               
                 3300020034|Ga0193753_10002988_10 
                 AACATCTGCTCGATCGATCCGAGATCGAGCC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 213) 
                 395) 
               
               
                   
               
               
                 3300020034|Ga0193753_10002988_9 
                 AACATCTGCTCGATCGATCCGAGATCGAGCC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 214) 
                 395) 
               
               
                   
               
               
                 3300020156|Ga0196970_1000866_40 
                 TGGAAACCCTGCGCAGGGGGTTAAAGCCTGCGAC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 215) 
                 396) 
               
               
                   
               
               
                 3300020579|Ga0210407_10000200_14 
                 GTCTCAATGGCTGCGACGAGCCGTGCAATCGTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 216) 
                 NO: 397) 
               
               
                   
               
               
                 3300020580|Ga0210403_10000550_35 
                 GTCTCAATGGCTGCGACGAGCCGTGCAATCGTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 216) 
                 NO: 397) 
               
               
                   
               
               
                 3300020580|Ga0210403_10001296_17 
                 CGCAAGCATTCGTCACAATCA (SEQ ID NO: 398) 
               
               
                 (SEQ ID NO: 217) 
                   
               
               
                   
               
               
                 3300020581|Ga0210399_10010852_9 
                 GTTGTAGAGGTAACGAAGCACCTGAAAGACTTCGAG (SEQ ID 
               
               
                 (SEQ ID NO: 218) 
                 NO: 399) 
               
               
                   
               
               
                 3300020583|Ga0210401_10033176_5 
                 GGTAGCGAAACACCTTGAAG (SEQ ID NO: 400) 
               
               
                 (SEQ ID NO: 217) 
                   
               
               
                   
               
               
                 3300005435|Ga0070714_100002341_12 
                 GTGGAAAAGAGCAGCGCGGGGCTCCAACGCCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 219) 
                 NO: 401) 
               
               
                   
               
               
                 3300009095|Ga0079224_100000262_28 
                 GCTGCAAAGGACGTGGCGTTCCTTGAACACGCCAAC (SEQ ID 
               
               
                 (SEQ ID NO: 220) 
                 NO: 402) 
               
               
                   
               
               
                 3300009095|Ga0079224_100170797_3 
                 GTTGCAATGCCGACTCCGCGGCTTGGTTGCGGAGAGG (SEQ ID 
               
               
                 (SEQ ID NO: 221) 
                 NO: 403) 
               
               
                   
               
               
                 3300010343|Ga0074044_10013672_1 
                 GTCGCAGGTGATGCTCTGAGGCTTTGGATCGGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 222) 
                 NO: 404) 
               
               
                   
               
               
                 3300010343|Ga0074044_10041345_4 
                 GTGGAAAGGGCAGCGCAGAGCCCGTGATGCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 223) 
                 NO: 405) 
               
               
                   
               
               
                 3300005468|Ga0070707_100000083_12 
                 CGGCGTGCCCTCGTCCTGCACCGTGATCCCGGC (SEQ ID NO: 
               
               
                 (SEQ ID NO: 224) 
                 406) 
               
               
                   
               
               
                 3300006163|Ga0070715_10000067_44 
                 GCGACTGCGTTTGCTCGGTGACGGGTTCACCGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 225) 
                 NO: 407) 
               
               
                   
               
               
                 3300014498|Ga0182019_10003703_1 
                 GTAACAATGCCAGCCCAGAGGCAAAGGTTCTGGGAC (SEQ ID 
               
               
                 (SEQ ID NO: 226) 
                 NO: 408) 
               
               
                   
               
               
                 3300001131|JGI12631J13338_1000296 
                 GTGCAGCCCCTGGGCACGTGGGCGACGG (SEQ ID NO: 409) 
               
               
                 _13 (SEQ ID NO: 227) 
                   
               
               
                   
               
               
                 3300001593|JGI12635J15846_ 
                 GTGCAGCCCCTGGGCACGTGGGCGACGG (SEQ ID NO: 409) 
               
               
                 10002852_1 (SEQ ID NO: 227) 
                   
               
               
                   
               
               
                 3300009813|Ga0105057_1000075_5 
                 GATCACACGGCGACCTCCGCCGCCTCGAAGCGGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 228) 
                 NO: 410) 
               
               
                   
               
               
                 3300009813|Ga0105057_1000075_5 
                 GATCACACGGCGACCTCCGCCGCCTCGAAGCGGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 229) 
                 NO: 410) 
               
               
                   
               
               
                 3300014489|Ga0182018_10031574_1 
                 CTCACAACGGCAGCGAGGCGCCTTGGAGTCCTCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 230) 
                 NO: 411) 
               
               
                   
               
               
                 3300014501|Ga0182024_10047267_8 
                 GTAGCAAGAGGTGCTCATGCCTCTAGAATATGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 231) 
                 NO: 412) 
               
               
                   
               
               
                 3300014501|Ga0182024_10150440_2 
                 GTAGCAAAGGCAGCTTGACGCCTTAAAGATCAAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 232) 
                 NO: 413) 
               
               
                   
               
               
                 3300001356|JGI12269J14319_ 
                 CTCGCAACGCCAGCGCAGGGGCCATGACGCTGCGAC (SEQ ID 
               
               
                 10001968_12 (SEQ ID NO: 233) 
                 NO: 414) 
               
               
                   
               
               
                 3300007533|Ga0102944_1012316_2 
                 GCATCAAAGGCAGTCCGATGCCTCTCAAATCGGAAC (SEQ ID 
               
               
                 (SEQ ID NO: 234) 
                 NO: 415) 
               
               
                   
               
               
                 3300005903|Ga0075279_10000001_30 
                 GTTGGAAAGGCTGCTCGAACGCCTTCAAGTCGAGAG (SEQ ID 
               
               
                 (SEQ ID NO: 235) 
                 NO: 416) 
               
               
                   
               
               
                 3300005524|Ga0070737_10002282_10 
                 CCGTGCGCAGCCGGATAACGCTGCGAC (SEQ ID NO: 417) 
               
               
                 (SEQ ID NO: 236) 
                   
               
               
                   
               
               
                 3300005524|Ga0070737_10031205_1 
                 GTCGCGAAGCTAGCGCAGAAGCTTGGTATCTGCGAG (SEQ ID 
               
               
                 (SEQ ID NO: 237) 
                 NO: 418) 
               
               
                   
               
               
                 3300005524|Ga0070737_10031205_1 
                 GTCGCGAAGCTAGCGCAGAAGCTTGGTATCTGCGAG (SEQ ID 
               
               
                 (SEQ ID NO: 238) 
                 NO: 418) 
               
               
                   
               
               
                 3300005534|Ga0070735_10023967_5 
                 GCATCAAGTCTTATCTCGC (SEQ ID NO: 419) 
               
               
                 (SEQ ID NO: 239) 
                   
               
               
                   
               
               
                 3300005542|Ga0070732_10013271_3 
                 GGCAGCGAAACGCCTTGAAG (SEQ ID NO: 420) 
               
               
                 (SEQ ID NO: 240) 
                   
               
               
                   
               
               
                 3300010373|Ga0134128_10000310_109 
                 GTGTAATGCCCGGCAGAAGGCTTTGGATTCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 241) 
                 NO: 421) 
               
               
                   
               
               
                 3300010373|Ga0134128_10011458_1 
                 GTAGCAATGCCTACCAAGAGGCTTTGTATCTTGTGAG (SEQ ID 
               
               
                 (SEQ ID NO: 242) 
                 NO: 422) 
               
               
                   
               
               
                 3300010373|Ga0134128_10096594_3 
                 GGCGCAAGCCCTGCGCGGGAGGGCAAGATCCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 243) 
                 NO: 423) 
               
               
                   
               
               
                 3300010400|Ga0134122_10000107_57 
                 CAAGCCACGCTCGGGTGGC (SEQ ID NO: 424) 
               
               
                 (SEQ ID NO: 244) 
                   
               
               
                   
               
               
                 3300010401|Ga0134121_10002041_17 
                 GGAGAGGGATCGTTTCTTCGACC (SEQ ID NO: 425) 
               
               
                 (SEQ ID NO: 245) 
                   
               
               
                   
               
               
                 3300004633|Ga0066395_10000027_32 
                 CCGACAACGCCTGCGCAGGGGCGTGGTTTCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 246) 
                 NO: 426) 
               
               
                   
               
               
                 3300005332|Ga0066388_100004304_4 
                 GGTGCAACGTGCCTTGCGAGGGCTTGATACTCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 247) 
                 NO: 427) 
               
               
                   
               
               
                 3300005332|Ga0066388_100004304_2 
                 GGTGCAACGTGCCTTGCGAGGGCTTGATACTCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 248) 
                 NO: 427) 
               
               
                   
               
               
                 3300005764|Ga0066903_100000051_27 
                 CCGACAACGCCTGCGCAGGGGCGTGGTTTCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 246) 
                 NO: 426) 
               
               
                   
               
               
                 3300010047|Ga0126382_10001209_14 
                 GGTGCAACGTGCCTTGCGAGGGCTTGATACTCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 249) 
                 NO: 427) 
               
               
                   
               
               
                 3300010047|Ga0126382_10001209_12 
                 GGTGCAACGTGCCTTGCGAGGGCTTGATACTCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 248) 
                 NO: 427) 
               
               
                   
               
               
                 3300010048|Ga0126373_10000093_102 
                 GTGGTAATGGCAGCGCAGCGCCTTTGAGACTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 250) 
                 NO: 428) 
               
               
                   
               
               
                 3300010366|Ga0126379_10001683_10 
                 GTTGCAGTACCCTGCTCACGGGGGAGACAAGTGAGAG (SEQ ID 
               
               
                 (SEQ ID NO: 251) 
                 NO: 429) 
               
               
                   
               
               
                 3300010376|Ga0126381_100020658_4 
                 GGTGAAATGGCATCGGGAGGCCACAAACGTTCCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 252) 
                 NO: 430) 
               
               
                   
               
               
                 3300010398 Ga0126383_10032213_5 
                 GTGATAGTGCCTGCTCAGTGGCTTAGT (SEQ ID NO: 431) 
               
               
                 (SEQ ID NO: 253) 
                   
               
               
                   
               
               
                 3300017961|Ga0187778_10004454_1 
                 GTGACAAGAGCAGCGCGGCGCTCTGCGAGCCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 254) 
                 NO: 432) 
               
               
                   
               
               
                 3300017970|Ga0187783_10000008_23 
                 CGAGTAGGCTTAGTTTGCTCGAC (SEQ ID NO: 433) 
               
               
                 (SEQ ID NO: 255) 
                   
               
               
                   
               
               
                 3300017972|Ga0187781_10019688_5 
                 GGCGAAGCGTCAGCGCAGCCGTCTCGAGGCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 256) 
                 NO: 434) 
               
               
                   
               
               
                 3300018064|Ga0187773_10011230_2 
                 GTCGCGATGGCTGCTCGACGCCAGGAAGATCGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 257) 
                 NO: 435) 
               
               
                   
               
               
                 3300012204|Ga0137374_10001132_4 
                 GTCGAAATGCCCGCGCGGGGGCGTCGTACCCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 258) 
                 NO: 436) 
               
               
                   
               
               
                 3300012210|Ga0137378_10000107_47 
                 GCGTGTAGTAAGAGCAGCGGTGTCGCTCTGAGATGCCGAC (SEQ 
               
               
                 (SEQ ID NO: 259) 
                 ID NO: 437) 
               
               
                   
               
               
                 3300012532|Ga0137373_10000316_4 
                 GTCGAAATGCCCGCGCGGGGGCGTCGTACCCGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 258) 
                 NO: 436) 
               
               
                   
               
               
                 3300012532|Ga0137373_10000407_43 
                 GCCCAAAGGCAGCTCGGCGCCTACAGAAGCCGAGAC (SEQ ID 
               
               
                 (SEQ ID NO: 260) 
                 NO: 438) 
               
               
                   
               
               
                 3300012930|Ga0137407_10020190_4 
                 GGTCGAAATGCCTGCGCAGGGGCTTCAACGCTGCGAC (SEQ ID 
               
               
                 (SEQ ID NO: 261) 
                 NO: 439) 
               
               
                   
               
               
                 330000598711071089|scaffold14955_2 
                 ATCGAAGAGCCTGCGCAGAGGCTTTTGATCTGCGAT (SEQ ID 
               
               
                 (SEQ ID NO: 262) 
                 NO: 440) 
               
               
                   
               
               
                 330000598811071091|scaffold06014_8 
                 ATCGAAGAGCCTGCGCAGAGGCTTTTGATCTGCGAT (SEQ ID 
               
               
                 (SEQ ID NO: 262) 
                 NO: 440) 
               
               
                   
               
               
                 330000605611071094|scaffold118627_ 
                 ATCGAAGAGCCTGCGCAGAGGCTTTTGATCTGCGAT (SEQ ID 
               
               
                 2 (SEQ ID NO: 262) 
                 NO: 440) 
               
               
                   
               
            
           
         
       
     
     REFERENCES 
     
         
         D. A. Benson et al., GenBank. Nucleic Acids Res. 41, D36-42 (2013). 
         K. D. Pruitt, T. Tatusova, G. R. Brown, D. R. Maglott, NCBI Reference Sequences (RefSeq): current status, new features and genome annotation policy. Nucleic Acids Res. 40, D130-135 (2012). 
         V. M. Markowitz et al., IMG: the Integrated Microbial Genomes database and comparative analysis system. Nucleic Acids Res. 40, D115-122 (2012). 
       
    
     Example 2—Functional Validation of Engineered CLUST.018837 CRISPR-Cas Systems (FIGS.  6 - 11 ) 
     Having identified the minimal components of CLUST.018837 CRISPR-Cas systems, we selected multiple example systems for functional validation, from the sources designated NZ_LDOS01000005 (SEQ ID NO: 1), 3300009004 (SEQ ID NO: 9), APMI01033782 (SEQ ID NO: 26), NZ_LVXZ01000012 (SEQ ID NO: 3), and ADIG01000806 (SEQ ID NO: 20). 
     DNA Synthesis and Effector Library Cloning 
     To test the activity of an exemplary CLUST.018837 CRISPR-Cas system, we designed and synthesized systems containing the pET28a(+) vector. The  E. coli  codon-optimized nucleic acid sequences encoding the selected CLUST.018837 effector proteins (amino acid sequence provided in TABLE 2) were synthesized (Genscript) and cloned into a custom expression system derived from the pET-28a(+) (EMD-Millipore) to create the Effector Plasmid. The engineered, non-naturally occurring vector included a nucleic acid encoding the CLUST.018837 effector protein under the control of a lac promoter and an  E. coli  ribosome binding sequence. The vector also included an acceptor site for a CRISPR array library driven by a J23119 promoter following the open reading frame for the CLUST.018837 effector protein ( FIGS.  6 A-D ). 
     For the minimal CRISPR array, we designed oligonucleotide library synthesis (OLS) pools comprising two direct repeats flanking natural-length spacer sequences targeting the pACYC184 plasmid, select  E. coli  essential genes, and non-targeting negative control spacers for a total of 8900 elements in the array library. The spacer length was determined by the mode of the spacer lengths found in the endogenous CRISPR array. Flanking the minimal CRISPR array were unique PCR priming sites that enabled amplification of a specific library from a larger pool of oligo synthesis. These sequences were placed under the control of a J23119 promoter and cloned into the Effector Plasmid in both the forward and reverse orientations for a total library of ˜18,000 plasmid elements 
     We next cloned the minimal CRISPR array library into the Effector Plasmid using the Golden Gate assembly method. Briefly, we first amplified each minimal CRISPR array from the OLS pool (Agilent Genomics) using unique PCR primers, and pre-linearized the plasmid backbone using BsaI to reduce potential background. Both DNA fragments were purified with Ampure® XP (Beckman Coulter) prior to addition to Golden Gate Assembly Master Mix (New England Biolabs) and incubated per the manufacturer&#39;s instructions. We further purified and concentrated the Golden Gate reaction to enable maximum transformation efficiency in the subsequent steps of the bacterial screen. 
     The plasmid library containing the distinct minimal CRISPR array and CLUST.018837 effector sequence was electroporated into E. Cloni® electrocompetent  E. coli  (Lucigen) using a Gene Pulser Xcell® (BioRad) following the protocol recommended by Lucigen. The library was co-transformed with purified pACYC184 plasmid, plated onto agar containing chloramphenicol (Fisher), tetracycline (Alfa Aesar), and kanamycin (Alfa Aesar) in BioAssay® dishes (Thermo Fisher), and incubated for 10-12 hours at 37° C. After estimation of approximate colony count to ensure sufficient library representation on the bacterial plate, the bacteria were harvested and plasmid DNA extracted using a QIAprep Spin Miniprep® Kit (Qiagen) to create an “output library.” By performing a PCR using custom primers containing barcodes and sites compatible with Illumina sequencing chemistry, we generated a barcoded next generation sequencing library from both the pre-transformation “input library” and the post-harvest “output library,” which were then pooled and loaded onto a Nextseq 550 (Illumina) to evaluate the effectors. At least two independent biological replicates were performed for each screen to ensure consistency. 
     Bacterial Screen Sequencing Analysis 
     Next generation sequencing (NGS) data for screen input and output libraries were demultiplexed using Illumina bcl2fastq. Reads in resulting fastq files for each sample contained the CRISPR array elements for the screening plasmid library. The direct repeat sequence of the CRISPR array was used to determine the array orientation, and the spacer sequence was mapped to the source (pACYC184 or  E. coli  essential genes) or negative control sequence (GFP) to determine the corresponding target. 
     To identify specific parameters resulting in enzymatic activity and bacterial cell death, we used NGS to quantify and compare the representation of individual CRISPR arrays (i.e., repeat-spacer-repeat) in the PCR product of the input and output plasmid libraries. We defined the array depletion ratio as the normalized output read count divided by the normalized input read count. An array was considered to be “strongly depleted” if the depletion ratio was less than 0.33 (more than 3-fold depletion). When calculating the array depletion ratio across biological replicates, we took the maximum depletion ratio value for a given CRISPR array across all experiments (i.e., a strongly depleted array must be strongly depleted in all biological replicates). We generated a matrix including array depletion ratios and the following features for each spacer target:target strand, transcript targeting, ORI targeting, target sequence motifs, flanking sequence motifs, and target secondary structure. We investigated the degree to which different features in this matrix explained target depletion for CLUST.018837 systems, thereby yielding a broad survey of functional parameters within a single screen. 
     We generated a matrix including array depletion ratios and the following features for each spacer target:target strand, transcript targeting, ORI targeting, target sequence motifs, flanking sequence motifs, and target secondary structure. We investigated the degree to which different features in this matrix explained target depletion for CLUST.018837 systems, thereby yielding a broad survey of functional parameters within a single screen. 
       FIGS.  7 A-E  show the degree of depletion activity of the engineered compositions by plotting for a given target the normalized ratio of sequencing reads in the screen output versus the screen input. 
     To quantify depletion activity, an enrichment ratio was calculated as R treated /R input , for each direct repeat and spacer. The normalized input read count was computed as:
 
 R   input =#reads containing  DR +spacer/total reads
 
     where the reads counts were obtained from next-generation sequencing of the plasmid DNA library expressing a CLUST.018837 effector and associated crRNA prior to transformation. The normalized treated read count was computed as:
 
 R   treated =(1+#reads containing  DR +spacer)/total reads
 
     where the read counts were obtained from next-generation sequencing of the plasmid DNA extracted from the surviving cells expressing CLUST.018837 effector and associated crRNA after antibiotic screening. A strongly depleted target had an enrichment less than ⅓, which was marked by the first vertical dashed line. Each CLUST.018837 effector was paired with a CRISPR array that took the form 5′-DR-[spacer]-DR-3′ or 5′-reverse_complement(DR)-[spacer]-reverse_complement(DR)-3′, and the depletion activity of both orientations of the DR are shown in the figure as indicated in the legend. 
     The results are plotted for each DR transcriptional orientation. In the functional screen for each composition, an active effector complexed with an active crRNA (expressed as a DR::spacer::DR) interferes with the ability of the pACYC184 to confer  E. coli  resistance to chloramphenicol and tetracycline, resulting in cell death and depletion of the spacer element within the pool. Comparing the results of deep sequencing the initial DNA library (screen input) versus the surviving transformed  E. coli  (screen output) suggest specific target sequences and DR transcriptional orientation that enable an active, programmable CRISPR-Cas system. The screen also indicates that the effector complex is only active with one orientation of the DR. 
       FIGS.  8 A-E  depicts the location of strongly depleted targets for CLUST.018837 systems targeting pACYC184, and  FIGS.  9 A-E  depicts the location of strongly depleted targets for CLUST.018837 systems targeting  E. coli  essential genes.  FIGS.  10 A-E  and  FIGS.  11 A-E  depict strongly depleted targets for the negative control, whereby the nucleotide sequence encoding the CLUST.018837 effector has been deleted from the construct being screened. Notably, the presence of many strongly depleted targets in  FIGS.  9 A-E  without corresponding activity in  FIGS.  11 A-E  indicates interference activity that is dependent upon the expression of the CLUST.018837 effector and programmed by the RNA guide. Conversely, the appearance of strongly depleted spacers in the region of the pACYC184 origin of replication in both  FIGS.  8 A-E  and  FIGS.  10 A-E  (particularly prominent in the case of 3300009004) suggests that the observed depletion activity in the origin of replication is not related to the CLUST.018837 effector activity. 
       FIGS.  12 A-E  depict a weblogos of the sequences flanking targets strongly depleted by CLUST.018837 CRISPR-Cas systems, indicating a prominent 5′ PAM of 5′-TTN-3′ or 5′-YTN-3′. 
     RNA-Sequencing Mature crRNA from In Vivo Bacterial Screen 
     Sequencing the small RNA from the in vivo bacterial screen began by extracting total RNA from harvested screen bacteria using the Direct-zol RNA MiniPrep® Plus w/ TRI Reagent (Zymo Research). Ribosomal RNA was removed using a Ribo-Zero® rRNA Removal Kit for Bacteria, followed by cleanup using a RNA Clean and Concentrator-5 kit. The resultant ribosomal RNA depleted total RNA was treated with T4 PNK, RNA 5′ polyphosphatase, prepared for sequencing using the NEBNext® Small RNA Library Prep Set. 
     We analyzed the pre-crRNA processing in the screen output samples for the direct repeat orientation that demonstrated successful targeting of pACYC184 and  E. coli  essential genes.  FIGS.  13 A-C  depict the alignment of extracted RNA against the input minimal CRISPR arrays, revealing the form of the mature crRNA. Mature crRNA sequences for example CLUST.018837 CRISPR-Cas systems are given in Table 4. 
                     TABLE 4                  Nucleotide Sequences of Mature crRNA of        Representative CLUST.O18837 CRISPR-Cas systems                     CLUST.018837           Effector           Protein           Accession   Mature crRNA Sequence               WP_081130164.1   TTTCATCGGCCATCGCGGCGGCCTCGTAGCTGCG       (SEQ ID NO: 1)   ACNNNNNNNNNNNNNNNNNN (SEQ ID NO:           1001)               WP_081130164.1   TTCATCGGCCATCGCGGCGGCCTCGTAGCTGCGA       (SEQ ID NO: 1)   CNNNNNNNNNNNNNNNNNN (SEQ ID NO:           1002)               3300009004|   ACAACAGCCATTACCCTGGCTTAGTAAGGGTGAC       Ga0100377_   NNNNNNNNNNNNNNNNNN (SEQ ID NO:       1000348_44   1003)       (SEQ ID NO: 9)                   ADIG01000806_20   TTCCAAGGCGATCACAGCCGCCTAGTAGTTGTGA       (SEQ ID NO: 20)   CNNNNNNNNNNNNNNNNNN (SEQ ID NO:           1004)                    
In Vitro pre-crRNA Processing
 
     In an effort to reconstitute processing of the NZ_LDOS0100005 pre-crRNA into a mature crRNA in vitro, we synthesized a pre-crRNA oligonucleotide template containing a T7 promoter followed the sequence, direct repeat (DR)-spacer1-DR-spacer2-DR. We PCR amplified the purified oligonucleotide template to select for full-length products and expressed the pre-crRNA using T7 in vitro transcription. The in vitro transcribed pre-crRNA was incubated with 0.0675 uM-1 μM of purified NZ_LDOS0100005 in 1×NEB Buffer2 with or without magnesium for 30 min. at 37° C. The resulting product was treated with proteinase K, supplemented with EDTA, denatured at 65° C. for 3 min., and run out on a 15% TBE-urea PAGE gel for analysis by SYBR-gold staining.  FIG.  14    shows pre-crRNA treated with effector protein is processed into a mature crRNA in a dose-dependent manner without a dependence on magnesium. 
     Example 3—Adaptation of CLUST.018837 CRISPR-Cas System Effectors for Eukaryotic and Mammalian Activity 
     DNA-modifying CRISPR-Cas systems such as CLUST.018837, systems described herein have important applications in eukaryotic cells such as therapeutic modification of the genome, with example modifications including but not limited to; genotype correction, gene knockout, genetic sequence insertion/deletion (by homology directed repair or otherwise), single nucleotide modification, or gene regulation. These gene modification modalities can utilize either natural or engineered activities of the CLUST.018837 CRISPR-Cas systems. 
     Without wishing to be limited, the applications in eukaryotic cells for the CLUST.018837 CRISPR-Cas system can be divided up into those utilizing nuclease and non-nuclease (also known as nuclease-dead) functionalities. For nucleases, in some embodiments, the natural nuclease activity of the CLUST.018837 CRISPR effector may be sufficient for applications such as gene modification, while in other embodiments, the targeted nuclease activity can be augmented by the fusion of additional nuclease domains (such as FokI) to either a nuclease-weak or nuclease-inactivated CLUST.018837 CRISPR effector. For non-nuclease functionalities, such nuclease-weak or nuclease inactivated CLUST.018837 CRISPR effectors can either be used directly or be fused to other functional domains. Both nuclease and non-nuclease functionalities are subsequently described in greater detail. 
     To develop CLUST.018837 CRISPR Cas systems for eukaryotic applications, the constructs encoding the protein effectors and/or their fusions are first codon-optimized for expression in mammalian cells, and specific localization tags are optionally appended to either or both the N-terminus or C-terminus of the effector protein. These localization tags can include sequences such as nuclear localization signal (NLS) sequences, which localize the effector to the nucleus for modification of genomic DNA. Other accessory proteins, such as fluorescent proteins, may be further appended. It has been demonstrated that the addition of robust, “superfolding” proteins such as superfolding green fluorescent protein (GFP) can increase the activity of CRISPR enzymes in mammalian cells when appended to the effector (Abudayyeh et al. (2017)  Nature  550(7675): 280-4, and Cox et al. (2017)  Science  358(6366): 1019-27). 
     The codon-optimized sequence coding for the CLUST.018837 effector and appended accessory proteins, fusion proteins, and/or localization signals is then cloned into a eukaryotic expression vector with the appropriate 5′ Kozak eukaryotic translation initiation sequence, eukaryotic promoters, and polyadenylation signals. In mammalian expression vectors, these promoters can include, e.g., general promoters such as CMV, EF1a, EFS, CAG, SV40, and cell-type specific RNA polymerase II promoters such as Syn and CamKIIa for neuronal expression, and thyroxine binding globulin (TBG) for hepatocyte expression to name a few. Similarly, useful polyadenylation signals include, but are not limited to, SV40, hGH, and BGH. For expression of the pre-crRNA or mature crRNA, RNA polymerase III promoters such as H1 or U6 can be used. 
     Delivery of the complete effector and RNA guide to the eukaryotic cells or tissues of choice can come in many different forms. For delivery to cells, in some embodiments. Transfection or nucleofection can deliver DNA or RNA from which the protein and/or RNA guide(s) is/are synthesized and assembled by the cellular machinery into active protein complexes, or the ribonucleoproteins (RNPs) themselves can be pre-formed extracellularly and delivered as a complete complex. Other applications may require the use of viral delivery, in which case the eukaryotic expression vector can be a lentiviral plasmid backbone, adeno-associated viral (AAV) plasmid backbone, or similar plasmid backbone capable of use in recombinant viral vector production. In particular, the small size of the CLUST.018837 CRISPR effectors make them ideally make them ideally suited for packaging, even when fused with other functional domains, along with its crRNA and appropriate control sequences into a single adeno-associated virus particle; the packaging size limit of 4.7 kb for AAV may preclude the use of larger effectors, particularly if large cell-type specific promoters are used for expression control. 
     After adapting the sequences, delivery vectors, and methods for eukaryotic and mammalian use, the different constructs as described herein are characterized for performance. For nuclease-based applications, in some instances, for testing of the mammalian nuclease activity of various constructs, we use a genomic dsDNA cleavage assay using either NGS or Surveyor nuclease readout to quantify the efficiency of indel formation (Hsu et al. (2013). In addition to testing various construct configurations and accessory sequences on individual targets, pooled library-based approaches are used to determine 1) any targeting dependency of specific constructs in mammalian cells as well as 2) the effect of mismatch locations and combinations along the length of the targeting crRNA. Briefly, the pooled library includes a selection plasmid that expresses a target DNA containing different flanking sequences as well as mismatches to the guide or guides used in the screening experiment, such that the successful target recognition and cleavage results in depletion of the sequence from the library. Furthermore, targeted indel sequencing or unbiased genome-wide cleavage assays can be used to evaluate the specificity of the CLUST.018837 nuclease constructs (Hsu et al. (2013), Tsai et al. (2015), Kim et al. (2015), Tsai et al. (2017)). 
     In addition to nuclease-based genome editing using CLUST.018837 effectors and a crRNA, additional template DNA sequences can be co-delivered either in a vector, such as an AAV viral vector, or as linear single stranded or double stranded DNA fragments. For insertion of template DNA by homology directed repair (HDR), template sequences are designed containing a payload sequence to be inserted into the locus of interest as well as flanking sequences that are homologous to endogenous sequences flanking the desired insertion site. In some instances, for insertion of short DNA payloads less than (for example: less than 1 kb in length), flanking homologous sequences can be short (for example: ranging from 15 to 200 nt in length). In other instances, for the insertion of long DNA payloads (for example: 1 kb or greater in length), long homologous flanking sequences are required to facilitate efficient HDR (for example: greater than 200 nt in length). Cleavage of target genomic loci for HDR between sequences homologous to template DNA flanking regions can significantly increase the frequency of HDR. CLUST.018837 effector cleavage events facilitating HDR include, but are not limited to dsDNA cleavage, double nicking, and single strand nicking activity. 
     Applications can also be based on non-nuclease functionalities of the CLUST.018837 effector and constructs from the fusion of the effector with a functional domain. In this context, the CLUST.018837 effector refers to both the natural effector amino acid sequence as well as any functional modifications to reduce or eliminate its nuclease activity. CLUST.018837 effectors have programmable DNA binding activity, which can be directly used in applications such as DNA immunoprecipitation, or other domains can be appended onto the effector to provide further functionality. Activities of these domains include, but are not limited to, DNA base modification (ex: ecTAD and its evolved forms, APOBEC), DNA methylation (m 6 A methyltransferases and demethylases), localization factors (KDEL retention sequence (SEQ ID NO: 1015), mitochondrial targeting signal), transcription modification factors (ex: KRAB, VP64). Additionally, domains can be appended to provide additional control, such as light-gated control (cryptochromes) and chemically inducible components (FKBP-FRB chemically inducible dimerization). 
     Optimizing the activity of such fusion proteins requires a systematic way of comparing linkers that connect the CLUST.018837 effector with the appended domain. These linkers may include, but are not limited to, flexible glycine-serine (GS) (“GS” disclosed as SEQ ID NO: 1005) linkers in various combinations and lengths, rigid linkers such as the alpha-helix forming EAAAK sequence (SEQ ID NO: 1016), XTEN linker (Schellenberger V, et al. Nat. Biotechnol. 2009; 27:1186-1190), as well as different combinations thereof (see TABLE 5). The various designs are then assayed in parallel over the same crRNA target complex and functional readout to determine which one yields the desired properties. 
     For adapting CLUST.018837 effectors for use in targeted DNA base modification (see, e.g., Gaudelli et al. (2017) “Programmable base editing of A⋅T to G⋅C in genomic DNA without DNA cleavage” Science 25 Oct. 2017), one begins with a panel of CLUST.018837 effectors that yielded strong interference activity in in vivo  E. coli  bacterial screens. These effectors, whether with nuclease-inactivating mutations or in their natural forms, are mammalian codon optimized and tested for specific and programmable dsDNA binding in an in vitro environment such as using an electrophoretic mobility shift assay (EMSA). 
     Next, a linker is used to create the fusion protein between CLUST.018837 effector and the base editing domain. Initially, this domain consists of the ecTadA(wt)/ecTadA*(7.10) heterodimer (hereafter referred to as the dCas12i-TadA heterodimer) engineered previously for hyperactivity and modification of dsDNA A⋅T dinucleotides to G⋅C (TABLE 7). Given the structural differences between the smaller CLUST.018837 effectors versus the previously characterized Cas9 effectors, alternate linker designs and lengths may yield the optimal design of the base editing fusion protein. Further optimization of the location of the nuclear localization sequence may also be required. 
     To evaluate the activity of the CLUST.018837-derived base editors, the HEK 293T cells are transiently transfected with the CLUST.018837 effector-TadA heterodimer construct, a plasmid expressing the crRNA, and optionally, a reporter plasmid if targeting the reporter and not an endogenous locus. The cells are harvested 48 hours after transient transfection, and the DNA is extracted and prepared for next generation sequencing. Analysis of the base composition of loci of samples containing the targeting vs. negative control non-targeting crRNAs provide information about the editing efficiency, and analysis of the sequences at computationally predicted sites of close sequence similarity yields information about the off-target activity. 
     One particular advantage of developing a DNA base editing system using CLUST.018837 effectors is that the small size, smaller than the existing Cas9 and Cas12a effectors, enables more ready packaging in AAV of CLUST.018837 effector-TadA heterodimer along with its crRNA and control elements without the need for protein truncations. This all-in-one AAV vector enables greater efficacy of in vivo base editing in tissues, which is particularly relevant as a path towards therapeutic applications of CLUST.018837 effectors. 
     
       
         
           
               
             
               
                 TABLE 5 
               
               
                   
               
               
                 Amino Acid Sequences of Motifs and Functional 
               
               
                 Domains in Engineered Variants of CLUST.018837 
               
               
                 CRISPR-Cas Effector Proteins 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 &gt;LINKER_1 
               
               
                 GS 
               
               
                 (SEQ ID NO: 1005) 
               
               
                   
               
               
                 &gt;LINKER_2 
               
               
                 GSGGGGS 
               
               
                 (SEQ ID NO: 1006) 
               
               
                   
               
               
                 &gt;LINKER_3 
               
               
                 GGGGSGGGGSGGGGS 
               
               
                 (SEQ ID NO: 1007) 
               
               
                   
               
               
                 &gt;LINKER_4 
               
               
                 GGSGGSGGSGGSGGSGGS 
               
               
                 (SEQ ID NO: 1008) 
               
               
                   
               
               
                 &gt;LINKER 5 (Gaudelli et al., 2017) 
               
               
                 SGGSSGGSSGSETPGTSESATPESSGGSSGGS 
               
               
                 (SEQ ID NO: 1009) 
               
               
                   
               
               
                 &gt;ecTadA(wt) (Gaudelli et al., 2017) [N-term 
               
               
                 fusion to ecTadA* (7.10)] 
               
               
                 MSEVEFSHEYWMRHALTLAKRAWDEREVPVGAVLVHNNRVIGEGWNRPIG 
               
               
                 RHDPTAHAEIMALRQGGLVMQNYRLIDATLYVTLEPCVMCAGAMIHSRIG 
               
               
                 RVVFGARDAKTGAAGSLMDVLHHPGMNHRVEITEGILADECAALLSDFFR 
               
               
                 MRRQEIKAQK KAQSSTD 
               
               
                 (SEQ ID NO: 1010) 
               
               
                   
               
               
                 &gt;ecTadA* (7.10) (Gaudelli et al., 2017) [N-term 
               
               
                 fusion to CRISPR nuclease] 
               
               
                 MSEVEFSHEYWMRHALTLAKRAWDEREVPVGAVLVHNNRVIGEGWNRPIG 
               
               
                 RHDPTAHAEIMALRQGGLVMQNYRLIDATLYVTLEPCVMCAGAMIHSRIG 
               
               
                 RVVFGARDAKTGAAGSLMDVLHHPGMNHRVEITEGILADECAALLSDFFR 
               
               
                 MRRQEIKAQK KAQSSTD 
               
               
                 (SEQ ID NO: 1011) 
               
               
                   
               
               
                 [Cytidine deaminase, AID, APOBEC1: N-term fusion 
               
               
                 (or optionally C-term)] 
               
               
                 &gt;AID-APOBEC1 (Dickerson et al., 2003, Komor et 
               
               
                 al., 2017) 
               
               
                 MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYWKRRDSATSFSLDFGYLRN 
               
               
                 KNGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGN 
               
               
                 PNLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTF 
               
               
                 VENHERTFKAWEGLHENSVRLSRQLRRILLPLYEVDDLRDAFRTLGL 
               
               
                 (SEQ ID NO: 1012) 
               
               
                   
               
               
                 &gt;Lamprey_AID-APOBECl (Rogozin et al., 2007, 
               
               
                 Komor et al., 2017) 
               
               
                 MTDAEYVRIHEKLDIYTFKKQFFNNKKSVSHRCYVLFELKRRGERRACFW 
               
               
                 GYAVNKPQSGTERGIHAEIFSIRKVEEYLRDNPGQFTINWYSSWSPCADC 
               
               
                 AEKILEWYNQELRGNGHTLKIWACKLYYEKNARNQIGLWNLRDNGVGLNV 
               
               
                 MVSEHYQCCRKIFIQSSHNQLNENRWLEKTLKRAEKRRSELSIMIQVKIL 
               
               
                 HTTKSPAV 
               
               
                 (SEQ ID NO: 1013) 
               
               
                   
               
               
                 &gt;APOBEC1_BE1 (Komor et al., 2016) 
               
               
                 MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINWGGRHSI 
               
               
                 WRHTSQNTNKHVEVNFIEKFTTERYFCPNTRCSITWFLSWSPCGECSRAI 
               
               
                 TEFLSRYPHVTLFIYIARLYHHADPRNRQGLRDLISSGVTIQIMTEQESG 
               
               
                 YCWRNFVNYSPSNEAHWPRYPHLWVRLYVLELYCIILGLPPCLNILRRKQ 
               
               
                 PQLTFFTIALQSCHYQRLPPHILWATGLK 
               
               
                 (SEQ ID NO: 1014) 
               
               
                   
               
            
           
         
       
     
     Other Embodiments 
     It is to be understood that while the invention has been described in conjunction with the detailed description thereof, the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.