Patent Publication Number: US-2021164056-A1

Title: Use of metastases-specific signatures for treatment of cancer

Description:
PRIORITY 
     This application claims the benefit of U.S. provisional application Ser. No. 62/703,237, filed on Jul. 25, 2018, which is incorporated by reference herein in its entirety. 
    
    
     STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT 
     This invention was made with government support under DE027445 awarded by the National Institutes of Health. The government has certain rights in the invention. 
    
    
     BACKGROUND OF THE INVENTION 
     Field of the Invention 
     This disclosure relates to compositions and methods for diagnosing and treating cancer, and head and neck squamous cells cancers (HNSCCs), breast cancers, and melanomas in particular. 
     Description of Related Art 
     Lymph node metastases (LNMs) represent an aggressive yet curable state for many solid tumors. The clinical significance of LNMs reflects, in part, an intermediate metastatic step during the sequential spread of cancers from the primary site to the lymph nodes and then to distant organs (1-3). Alternatively, LNMs may not directly lead to distant metastases but reflect the biological selection of more aggressive subpopulations that are associated with increased local and/or regional recurrence (4-6). The presence of LNMs is associated with decreased survival in gastric cancers, melanomas, and breast cancers among others (7-9). Similarly, LNMs are one of the most important prognostic features in head and neck squamous cells cancers (HNSCCs) (10), where the survival of patients with LNMs is approximately half the survival of patients without LNMs (11, 12). However, despite these worse outcomes, LNMs represent a heterogeneous disease state as evidenced by the inability of existing lymph node staging systems to accurately predict locoregional control, distant metastasis, and/or survival (13). Previous investigators have tried to stratify patients with LNMs using clinicopathological features including lymph node density, tumor and/or lymph node location, and extracapsular extension, among others (14, 15). Although several groups have sought to biologically classify LNMs in HNSCCs, and in other cancers, these efforts have primarily focused on differences between LNMs and the primary tumor rather than defining distinct subtypes within LNMs (16, 17). Given that approximately 50-60% of HNSCC patients present with LNMs (18), identifying LNM subtypes based on intrinsic molecular differences would likely provide novel biological and prognostic information. 
     Unsupervised integrative clustering of 72 LNMs was used to identify three distinct LNM-specific molecular subtypes associated with different rates of locoregional control and survival. The most aggressive LNM subtype displayed a lymph node-specific gene expression signature that was prognostic across multiple cancer types and was enriched for genes associated with an invasive subtype. 
     In many cancers, LNMs portend for worse chances for survival. However, the heterogeneous outcomes of patients with LNMs indicate a need to identify subgroups of patients at increased risk of disease recurrence. Using unsupervised clustering of RNA and miRNA profiles, three novel subtypes of LNMs were identified in Human Papillomavirus-negative Head and Neck cancers. One LNM-specific subtype had a 10-fold higher risk of locoregional recurrence in head and neck cancers and predicted for worse disease control and/or survival in breast cancers and melanomas. Identification of this aggressive subtype in patients will enable better risk stratification of patients and the selection of patients for treatment escalation. Furthermore, gene pathways selectively activated in this high risk subtype will facilitate the identification of new targets to more precisely treat patients at increased risk of disease recurrence. Finally, these results likely extend to other cancer types. 
     SUMMARY OF THE INVENTION 
     This disclosure identified three distinct molecular subtypes of LNMs that were associated with differences in clinical outcomes after surgery and post-operative radiotherapy. These subtypes, termed Group 1, Group 2, and Group 3, displayed an immune, an invasive, and a metabolic/proliferative phenotype, respectively. The Group 2 LNM subtype was associated with significantly worse locoregional control, relapse-free survival, and overall survival. This predictive classifier was established in HNSCCs and validated in breast adenocarcinomas, and in melanomas. Since this classifier was predictive in epithelial cancers of different histologies, as well as in non-epithelial cancers, this classifier is likely predictive in all cancer types. The common biological pathways were enriched in these distinct cancer types further supporting the role of this classifier in pan-cancer analyses. Finally, the enriched pathways are commonly associated with poor prognostic features across many cancers. Thus, this signature is predictive for multiple cancer types. 
     In a first aspect, the invention provides a method for treating cancer in a subject, the method comprising:
         (a) obtaining a sample comprising lymph node metastasis (LNM) cells from the subject;   (b) measuring gene expression levels in the sample of at least ten genes selected from the group consisting of: TGFBR1, OLR1, PDGFC, ACE, MGA, PAPPA, APBB2, CARD19, SPDYE3, ACOT9, C1QTNF6, FAM153B, C10orf55, SLC25A33, KAT7, MUC20, ENTPD7, GOLT1B, PPRC1, ITPRIPL2, ZC3H12C, ARF4, COL27A1, ZNF850, VKORC1, RBM23, CAPG, TOR4A, METTL21B, TRMT2B, EVC, ZBTB14, PFDN1, FBXO25, B4GALT1, NTMT1, FAM227B, AGTRAP, RRAS, STRIP2, HECTD3, SH3BGRL2, LHFPL2, WHSC1L1, DCBLD1, SPRED1, BTBD18, FTSJ1, GSTO1, FAM102A, ZDHHC8, PDGFB, SDHAF4, PCBP4, HRH1, FMC1, FLNB, RPAIN, TAS2R4, TUBD1, FKBP14, METTL21A, TANC2, POLB, XKR4, ZNF19, NOX5, HBP1, C1orf56, KCNJ15, NDOR1, 43351, and PHACTR3;   (c) determining a LNM-specific molecular subtype comprising the gene expression levels of the at least ten genes;   (d) providing an indication as to the outcome of locoregional control (LRC), relapse-free survival (RFS), and/or overall survival (OS) when the LNM-specific molecular subtype indicates that the expression levels of the at least ten genes are altered in a predictive manner; and   (e) administering an aggressive cancer treatment regimen to the subject when a determination is made that the subject has LNM cells with decreased LRC, decreased RFS, and/or decreased OS.       

     In certain embodiments of the first aspect, measuring gene expression levels of the at least ten genes comprises measurement by RNA-sequencing, miRNA sequencing, microarrays, Real-Time PCR (RT-PCR; including quantitative RT-PCR), microRNA, nanostring or other hybridization detection methods, immunohistochemistry/Western blot analyses, nuclease protection assays, and Northern blot analyses. 
     In certain embodiments of the first aspect, the LNM cells from the subject are obtained from a primary cancer selected from the group consisting of: human papillomavirus-negative head and neck cancer, head and neck squamous cell cancer, breast cancer, melanoma, acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), adrenocortical carcinoma, kaposi sarcoma, aids-related lymphoma, primary CNS lymphoma, anal cancer, appendix cancer, astrocytomas, brain cancer, atypical teratoid/rhabdoid tumor, basal cell carcinoma of the skin, bile duct cancer, bladder cancer, bone cancer, bronchial tumors, Burkitt lymphoma, non-Hodgkin lymphoma, carcinoid tumor (gastrointestinal), cardiac tumors, cervical cancer, cholangiocarcinoma, chordoma, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), colorectal cancer, craniopharyngioma, cutaneous t-cell lymphoma, ductal carcinoma in situ (DCIS), endometrial cancer, esophageal cancer, esthesioneuroblastoma, extragonadal germ cell tumor, eye cancer, intraocular melanoma, retinoblastoma, fallopian tube cancer, gallbladder cancer, gastric cancer, gastrointestinal carcinoid tumor, gastrointestinal stromal tumors (GIST), germ cell tumors, gestational trophoblastic disease, hairy cell leukemia, head and neck cancer, liver cancer, Hodgkin lymphoma, hypopharyngeal cancer, islet cell tumors, pancreatic neuroendocrine tumors, Langerhans cell histiocytosis, laryngeal cancer, leukemia, lip and oral cavity cancer, lung cancer, lymphoma, Merkel cell carcinoma, mesothelioma, plasma cell neoplasms, mycosis fungoides, myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, nasal cavity and paranasal sinus cancer, nasopharyngeal cancer, neuroblastoma, non-small cell lung cancer, oral cancer, oropharyngeal cancer, osteosarcoma, ovarian cancer, pancreatic cancer, paraganglioma, parathyroid cancer, penile cancer, multiple myeloma, prostate cancer, renal cell cancer, retinoblastoma, rhabdomyosarcoma, salivary gland cancer, sarcoma, uterine sarcoma, small cell lung cancer, small intestine cancer, soft tissue sarcoma, t-cell lymphoma, testicular cancer, throat cancer, thymoma, thyroid cancer, urethral cancer, uterine cancer, vaginal cancer, and Wilms tumor. 
     In certain embodiments of the first aspect, the primary cancer is a head and neck squamous cell cancer. 
     In certain embodiments of the first aspect, the primary cancer is breast cancer. 
     In certain embodiments of the first aspect, the primary cancer is melanoma. 
     In certain embodiments of the first aspect, the aggressive cancer treatment regimen comprises surgical resection of the primary tumor and lymph node dissection followed by radiotherapy with or without chemotherapy 
     In certain embodiments of the first aspect, the lymph node metastasis is taken from a formalin-fixed, paraffin-embedded sample. In some embodiments, samples may be isolated from fine needle aspirates, or fresh frozen tissues. 
     In certain embodiments of the first aspect, the subject is a human. 
     In a second aspect, the invention provides a method for predicting outcome of locoregional control (LRC), relapse-free survival (RFS), and/or overall survival (OS) of a lymph node metastasis (LNM) in a subject, the method comprising:
         (a) obtaining a sample comprising LNM cells from the subject;   (b) measuring gene expression levels in the sample of at least ten genes selected from the group consisting of: TGFBR1, OLR1, PDGFC, ACE, MGA, PAPPA, APBB2, CARD19, SPDYE3, ACOT9, C1QTNF6, FAM153B, C10orf55, SLC25A33, KAT7, MUC20, ENTPD7, GOLT1B, PPRC1, ITPRIPL2, ZC3H12C, ARF4, COL27A1, ZNF850, VKORC1, RBM23, CAPG, TOR4A, METTL21B, TRMT2B, EVC, ZBTB14, PFDN1, FBXO25, B4GALT1, NTMT1, FAM227B, AGTRAP, RRAS, STRIP2, HECTD3, SH3BGRL2, LHFPL2, WHSC1L1, DCBLD1, SPRED1, BTBD18, FTSJ1, GSTO1, FAM102A, ZDHHC8, PDGFB, SDHAF4, PCBP4, HRH1, FMC1, FLNB, RPAIN, TAS2R4, TUBD1, FKBP14, METTL21A, TANC2, POLB, XKR4, ZNF19, NOX5, HBP1, C1orf56, KCNJ15, NDOR1, 43351, and PHACTR3;   (c) determining a LNM-specific molecular subtype comprising the gene expression levels of the at least ten genes; and   (d) providing an indication as to the outcome of LRC, RFS, and/or OS when the LNM-specific molecular subtype indicates that the expression levels of the at least ten genes are altered in a predictive manner.       

     In certain embodiments of the second aspect, the LNM-specific molecular subtype for the LNM is classified as Group 1, Group 2, or Group 3. In certain embodiments, Group 1 indicates an immune subtype, Group 2 indicates a significantly worse LRC, RFS, and/or OS, and Group 3 indicates a metabolic/proliferative subtype. 
     In certain embodiments of the second aspect, measuring gene expression levels of the at least ten genes comprises measurement by RNAseq, miRNAseq, RT-PCR, nanostring, or other hybridization detection methods, immunohistochemistry/western blot analyses, nuclease protection assays, or Northern blot analyses. 
     In certain embodiments of the second aspect, the LNM cells from the subject are obtained from a primary cancer selected from the group consisting of: human papillomavirus-negative head and neck cancer, head and neck squamous cell cancer, breast cancer, melanoma, acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), adrenocortical carcinoma, kaposi sarcoma (soft tissue sarcoma), aids-related lymphoma, primary CNS lymphoma, anal cancer, appendix cancer, astrocytomas, brain cancer, atypical teratoid/rhabdoid tumor, basal cell carcinoma of the skin, bile duct cancer, bladder cancer, bone cancer (including Ewing sarcoma and osteosarcoma and malignant fibrous histiocytoma), brain tumors, bronchial tumors, Burkitt lymphoma, non-Hodgkin lymphoma, carcinoid tumor (gastrointestinal), cardiac (heart) tumors, cervical cancer, cholangiocarcinoma, chordoma, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), colorectal cancer, craniopharyngioma, cutaneous T-cell lymphoma, ductal carcinoma in situ (DCIS), endometrial cancer (uterine cancer), esophageal cancer, esthesioneuroblastoma, extragonadal germ cell tumor, eye cancer, intraocular melanoma, retinoblastoma, fallopian tube cancer, gallbladder cancer, gastric (stomach) cancer, gastrointestinal carcinoid tumor, gastrointestinal stromal tumors (GIST), germ cell tumors, gestational trophoblastic disease, hairy cell leukemia, head and neck cancer, liver cancer, Hodgkin lymphoma, hypopharyngeal cancer, islet cell tumors, pancreatic neuroendocrine tumors, Langerhans cell histiocytosis, laryngeal cancer, leukemia, lip and oral cavity cancer, lung cancer, lymphoma, Merkel cell carcinoma, mesothelioma, plasmamesothelioma, plasma cell neoplasms, mycosis fungoides, myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, nasal cavity and paranasal sinus cancer, nasopharyngeal cancer, neuroblastoma, non-small cell lung cancer, oral cancer, oropharyngeal cancer, osteosarcoma, ovarian cancer, pancreatic cancer, paraganglioma, parathyroid cancer, penile cancer, multiple myeloma, prostate cancer, rectal cancer, renal cell (kidney) cancer, retinoblastoma, rhabdomyosarcoma, salivary gland cancer, sarcoma, uterine sarcoma, small cell lung cancer, small intestine cancer, soft tissue sarcoma, T-cell lymphoma, testicular cancer, throat cancer, thymoma, thyroid cancer, urethral cancer, uterine cancer, vaginal cancer, and Wilms tumor. 
     In certain embodiments of the second aspect, the primary cancer is a head and neck squamous cell cancer. 
     In certain embodiments of the second aspect, the primary cancer is breast cancer. 
     In certain embodiments of the second aspect, the primary cancer is melanoma. 
     In certain embodiments of the second aspect, the lymph node metastasis is taken from a formalin-fixed, paraffin-embedded sample. In some embodiments, samples may be isolated from fine needle aspirates, or fresh frozen tissues. 
     In certain embodiments of the second aspect, the subject is a human. 
     These and other features and advantages of the present invention will be more fully understood from the following detailed description taken together with the accompanying claims. It is noted that the scope of the claims is defined by the recitations therein and not by the specific discussion of features and advantages set forth in the present description. 
    
    
     
       BRIEF DESCRIPTION OF DRAWINGS 
         FIGS. 1A-1H : Integrative analysis of lymph node metastasis from head and neck cancers identified 3 molecular subtypes having different rates of locoregional control and relapse-free survival. ( 1 A) Schema of analysis. 34 patients with HNSCCs underwent surgery followed by adjuvant radiotherapy±cisplatin-based chemotherapy. 72 lymph node metastasis underwent RNAseq and miRNAseq followed by integrative clustering (iCluster) analysis to identify 3 groups: Group 1, Group 2 and Group 3. ( 1 B- 1 D) Group 2 is associated with significantly worse disease control as assessed by ( 1 B) locoregional control, ( 1 C) local-only control, and ( 1 D) relapse-free survival. ( 1 E) Heat map of 2039 DEmRNAs between Group 1, Group 2 and Group 3 LNMs with FDR&lt;0.05 and ≥1.5-fold expression. ( 1 F- 1 H) Consensus clustering of DEmRNAs confirms 3 distinct groups as the optimal clustering. ( 1 F) Consensus clustering, ( 1 G) consensus CDF, ( 1 H) Proportion of ambiguous clustering. 
         FIGS. 2A-2F : Group 2 LNM subtype was enriched in invasive gene signatures. ( 2 A- 2 C) Heat map of normalized enrichment scores obtained using GSEA on the Hallmark pathway divided into pathways showing enrichment in Group 2 only ( 2 A), Group 1 and 2 ( 2 B) or Group 2 and 3 ( 2 C) (for  2 A- 2 C; *, **, and *** indicates FDR&lt;0.25 for Group 1, Group 2, and Group 3 LNMs, respectively). ( 2 D- 2 F) GESA enrichment plot for the Hallmark Epithelial Mesenchymal Transition Signature. 
         FIGS. 3A-3F : LNM subtypes were not present in the matched primary tumor. ( 3 A) Integrative clustering of primary tumors identified 2 molecular subgroups that were not associated with differences in locoregional control (LRC). ( 3 B) Heat map of Tumor Group 1 and Tumor Group 2 DEmiRNA. Consensus clustering 2039 DEG confirms 3 distinct groups. ( 3 C) Consensus clustering confirms 2 molecular subgroups in primary HNSCC tumors. ( 3 D) Consensus clustering of primary tumors using DEG identified in LNMs identifies 6 subgroups of primary tumors. ( 3 E) Proportion of ambiguous clustering identifies k=6 as optimal clustering using DEGs from lymph node metastases. ( 3 F) Clustering of primary tumors using lymph node metastases DEGs does not identify subgroups associated with improved survival. 
         FIGS. 4A-4D : The gene expression patterns of lymph node metastasis better predicted for patients at higher risk of locoregional failure. The prognostic performance of 4 HNSCC classifiers was tested on primary tumor (left panel) and LNMs (right panel). ( 4 A) 172 gene signature significantly predicted LRC only in the lymph node metastases cohort. High risk and Low risk were determined as greater than or less than the average trait value, respectively. ( 4 B) 30 gene Prognostic Index (PI) had a lower log-rank test p-value for LRC in the lymph node metastases cohort. PI-high and PI-low were determined as greater or less than the median 30 gene PI value, respectively. ( 4 C) 10 gene radiosensitivity index (RSI) significantly predicted LRC only in the lymph node metastases cohort. Responder and Non-Responders were determined as the lesser than or greater than the 25 th  RSI percentile, respectively. ( 4 D) 13 gene oral cavity squamous cell carcinoma risk score significantly predicted LRC only in the lymph node metastases cohort. High risk and Low risk were determined as greater than or less than the median risk score, respectively. 
         FIGS. 5A-5C : A 73 gene LNM-specific classifier predicted outcomes only in LNMs across multiple cancer types. ( 5 A) LRC of UIC HNSCC patients stratified by Group 2 or Group 1 &amp; 3 subtypes in LNMs (left panel) and matched primary tumors (right panel). ( 5 B) OS in a prospective breast cancer cohort stratified by Group 2 or Group 1 &amp; 3 subtypes in LNMs (left panel) or other recurrent disease sites (right panel). ( 5 C) Disease specific survival in a retrospective melanoma cohort stratified by Group 2 or Group 1&amp;3 subtypes in LNMs (left panel) or other disease sites (right panel). 
         FIGS. 6A-6C : A 73 gene classifier identified similar Group 2-like subtype in breast cancers, melanoma, and HNSCCs. EGSEA comparing Group 2 and Group 1 &amp; 3 subtypes from breast cancer, melanoma, and two HNSCC datasets (MDA HNSCC and UIC HNSCC) using Hallmark and KEGG. The median rank was used for all pathways. ( 6 A) Heat map of EGSEA for Hallmark pathways. ( 6 B) Heat map of EGSEA of KEGG supergroup pathways grouped by supergroup. ( 6 C) Heat map of EGSEA of individual KEGG pathways. Common Hallmark and KEGG pathways were highly ranked across all Group 2-like subtypes. 
         FIG. 7 : shows a schematic of process for patient selection. 
         FIGS. 8A-8F : Outcomes in HNSCC cohort. Kaplan-Meier analysis of: ( 8 A) Locoregional control. ( 8 B) Local-only control. ( 8 C) Relapse-free survival. ( 8 D) Regional control. ( 8 E) Distant control. ( 8 F) Overall survival. 
         FIGS. 9A-9C : Outcomes by molecular subtypes of LNMs. Kaplan-Meier analysis of: ( 9 A) Regional control. ( 9 B) Distant control. ( 9 C) Overall survival. 
         FIGS. 10A-10G : DEmiRNAs in LNMs subtypes. ( 10 A) Heat map of 24 DEmiRNAs. ( 10 B) Proportion of ambiguous clustering plot using 24 DEmiRNAs to determine optimal clustering of lymph node metastasis. Lowest PAC value infers the optimal k (k=2). ( 10 C- 10 G) Upper panels, Heat maps of the consensus matrix for the predefined cluster ( 10 C) k=2, ( 10 D) k=3, ( 10 E) k=4, ( 10 F) k=5 and ( 10 G) k=6. Lower panels, Kaplan-Meier plots for locoregional control of the patients stratified by their consensus cluster membership. P-value determined using log-rank test. 
         FIGS. 11A-11H : Consensus clustering of pairwise DEGs for other predefined cluster numbers does not identify other LNMs subtypes that predict for disease recurrence. ( 11 A,  11 C,  11 E &amp;  11 G) Heat map of the consensus matrix for the predefined cluster number ( 11 A) k=2, ( 11 C) k=4, ( 11 E) k=5 and ( 11 G) k=6. ( 11 B,  11 D,  11 F &amp;  11 H) Kaplan-Meier plot for locoregional control of the patients stratified by the consensus cluster membership in ( 11 B) k=2, ( 11 D) k=4, ( 11 F) k=5 and ( 11 H) k=6. P value determined by the log-rank test. 
         FIGS. 12A-12B : Enrichment of KEGG pathways in LNMs subtypes. ( 12 A) Heat map for the average enrichment scores of KEGG super pathways demonstrating for Group 1, Group 2, Group 3. ( 12 B) Heat map for individual KEGG pathways enriched in Group 1 (*), Group 2 (**) or Group 3 (***). 
         FIGS. 13A-13D : The transcriptome of lymph node metastasis better predicts for patients at higher risk of relapse or death. The prognostic performance of 4 HNSCC classifiers was tested on primary tumor (left panel) and lymph node metastasis (right panel). ( 13 A) 172 gene signature significantly predicted RFS in both the primary tumor in the lymph node metastases cohort. High risk and Low risk were determined as greater than or less than the average trait value, respectively. ( 13 B) 30 gene Prognostic Index (PI) had significantly predicted RFS only in the lymph node metastases cohort. PI-high and PI-low were determined as greater or less than the median 30 gene PI value, respectively. ( 13 C) 10 gene radiosensitivity index (RSI) significantly predicted RFS only in the lymph node metastases cohort. Responder and Non-Responders were determined as the lesser than or greater than the 25 th  RSI percentile, respectively. ( 13 D) 13 gene oral cavity squamous cell carcinoma risk score significantly predicted RFS in both the primary tumor and in the lymph node metastases cohort. High risk and Low risk were determined as greater than or less than the median risk score, respectively. 
         FIG. 14 : shows a Receiver-Operator Curve for a 73 gene LNM-classifier. 
     
    
    
     DETAILED DESCRIPTION 
     All publications, patents, and patent applications cited herein are hereby expressly incorporated by reference in their entirety for all purposes. 
     Before describing the present invention in detail, a number of terms will be defined. As used herein, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. 
     It is noted that terms like “preferably,” “commonly,” and “typically” are not utilized herein to limit the scope of the claimed invention or to imply that certain features are critical, essential, or even important to the structure or function of the claimed invention. Rather, these terms are merely intended to highlight alternative or additional features that can or cannot be utilized in a particular embodiment of the present invention. 
     For the purposes of describing and defining the present invention it is noted that the term “substantially” as used herein represents the inherent degree of uncertainty that can be attributed to any quantitative comparison, value, measurement, or other representation. The term “substantially” is also used herein to represent the degree by which a quantitative representation can vary from a stated reference without resulting in a change in the basic function of the subject matter at issue. 
     As used herein, the terms “or” and “and/or” is utilized to describe multiple components in combination or exclusive of one another. For example, “x, y, and/or z” can refer to “x” alone, “y” alone, “z” alone, “x, y, and z,” “(x and y) or z,” “x or (y and z),” or “x or y or z.” 
     As used herein, the term “about” refers to ±10% of a given value. 
     In a first aspect, the present disclosure provides a method for treating cancer in a subject, the method comprising:
         (a) obtaining a sample comprising lymph node metastasis (LNM) cells from the subject;   (b) measuring gene expression levels in the sample of at least ten genes selected from the group consisting of: TGFBR1, OLR1, PDGFC, ACE, MGA, PAPPA, APBB2, CARD19, SPDYE3, ACOT9, C1QTNF6, FAM153B, C10orf55, SLC25A33, KAT7, MUC20, ENTPD7, GOLT1B, PPRC1, ITPRIPL2, ZC3H12C, ARF4, COL27A1, ZNF850, VKORC1, RBM23, CAPG, TOR4A, METTL21B, TRMT2B, EVC, ZBTB14, PFDN1, FBXO25, B4GALT1, NTMT1, FAM227B, AGTRAP, RRAS, STRIP2, HECTD3, SH3BGRL2, LHFPL2, WHSC1L1, DCBLD1, SPRED1, BTBD18, FTSJ1, GSTO1, FAM102A, ZDHHC8, PDGFB, SDHAF4, PCBP4, HRH1, FMC1, FLNB, RPAIN, TAS2R4, TUBD1, FKBP14, METTL21A, TANC2, POLB, XKR4, ZNF19, NOX5, HBP1, C1orf56, KCNJ15, NDOR1, 43351, and PHACTR3;   (c) determining a LNM-specific molecular subtype comprising the gene expression levels of the at least ten genes;   (d) providing an indication as to the outcome of locoregional control (LRC), relapse-free survival (RFS), and/or overall survival (OS) when the LNM-specific molecular subtype indicates that the expression levels of the at least ten genes are altered in a predictive manner; and   (e) administering an aggressive cancer treatment regimen to the subject when a determination is made that the subject has LNM cells with decreased LRC, decreased RFS, and/or decreased OS.       

     In certain embodiments of the first aspect, the aggressive cancer treatment regimen comprises surgical resection of the primary tumor and lymph node dissection followed by radiotherapy with or without chemotherapy. 
     As defined herein, the term “LNM-specific molecular subtype” refers to a subtype determined by any combination of genes, the measured messenger RNA transcript expression levels, cDNA levels, or direct DNA expression levels, or immunohistochemistry levels of which can be used to distinguish between two biologically different tissues and/or cells and/or cellular changes. In certain embodiments, a LNM-specific molecular subtype is comprised of the gene-expression levels of at least 100, 99, 98, 97, 96, 95, 94, 93, 92, 91, 90, 89, 88, 87, 86, 85, 84, 83, 82, 81, 80, 79, 78, 77, 76, 75, 74, 73, 72, 71, 70, 69, 68, 67, 66, 65, 64, 63, 62, 61, 60, 59, 58, 57, 56, 55, 54, 53, 52, 51, 50, 49, 48, 47, 46, 45, 44, 43, 42, 41, 40, 39, 38, 37, 36, 35, 34, 33, 32, 31, 30, 29, 28, 27, 26, 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, or 10 genes or less. In an embodiment, the LNM-specific molecular subtype is determined by measuring the expression of 73 genes. In certain embodiments, the genes are selected from: TGFBR1, OLR1, PDGFC, ACE, MGA, PAPPA, APBB2, CARD19, SPDYE3, ACOT9, C1QTNF6, FAM153B, C10orf55, SLC25A33, KAT7, MUC20, ENTPD7, GOLT1B, PPRC1, ITPRIPL2, ZC3H12C, ARF4, COL27A1, ZNF850, VKORC1, RBM23, CAPG, TOR4A, METTL21B, TRMT2B, EVC, ZBTB14, PFDN1, FBXO25, B4GALT1, NTMT1, FAM227B, AGTRAP, RRAS, STRIP2, HECTD3, SH3BGRL2, LHFPL2, WHSC1L1, DCBLD1, SPRED1, BTBD18, FTSJ1, GSTO1, FAM102A, ZDHHC8, PDGFB, SDHAF4, PCBP4, HRH1, FMC1, FLNB, RPAIN, TAS2R4, TUBD1, FKBP14, METTL21A, TANC2, POLB, XKR4, ZNF19, NOX5, HBP1, C1orf56, KCNJ15, NDOR1, 43351, and PHACTR3 (also see Table 6). 
     In certain embodiments of the first aspect, measuring gene expression levels of the at least ten genes comprises measurement by RNAseq, miRNAseq, or RT-PCR of the at least ten genes. The phrase “measuring the gene-expression levels” or “determining the gene-expression levels” as used herein refers to determining or quantifying RNA or proteins expressed by the gene or genes. The term “RNA” includes mRNA transcripts, and/or specific spliced variants of mRNA. The term “RNA product of the gene” as used herein refers to RNA transcripts transcribed from the gene and/or specific spliced variants. In some embodiments, mRNA is converted to cDNA before the gene expression levels are measured. In the case of “protein”, it refers to proteins translated from the RNA transcripts transcribed from the gene. The term “protein product of the gene” refers to proteins translated from RNA products of the gene. A number of methods can be used to detect or quantify the level of RNA products of the gene or genes within a sample, including: RNA-sequencing, miRNA sequencing, microarrays, Real-Time PCR (RT-PCR; including quantitative RT-PCR), nanostring or other hybridization detection methods, immunohistochemistry/Western blot analyses, nuclease protection assays, and Northern blot analyses. In addition, a person skilled in the art will appreciate that a number of methods can be used to determine the amount of a protein product of a gene of the invention, including immunoassays such as western blots, ELISA, and immunoprecipitation followed by SDS-PAGE and immunocytochemistry. In certain embodiments, the expression level of each gene in the gene set is determined by reverse transcribing the isolated RNA, miRNA, or mRNA into cDNA and measuring a level of fluorescence for each gene in the gene set by a nucleic acid sequence detection system following Real-Time Polymerase Chain Reaction (RT-PCR). 
     A person skilled in the art will appreciate that a number of detection agents can be used to determine gene expression. For example, to detect RNA products of the biomarkers, probes, primers, complementary nucleotide sequences or nucleotide sequences that hybridize to the RNA products can be used. In another example, to detect cDNA products of the biomarkers, probes, primers, complementary nucleotide sequences or nucleotide sequences that hybridize to the cDNA products can be used. To detect protein products of the biomarkers, ligands or antibodies that specifically bind to the protein products can be used. 
     In certain embodiments of the first aspect, the LNM cells from the subject are obtained from a primary cancer selected from the group consisting of: human papillomavirus-negative head and neck cancer, head and neck squamous cell cancer, breast cancer, melanoma, acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), adrenocortical carcinoma, kaposi sarcoma, aids-related lymphoma, primary CNS lymphoma, anal cancer, appendix cancer, astrocytomas, brain cancer, atypical teratoid/rhabdoid tumor, basal cell carcinoma of the skin, bile duct cancer, bladder cancer, bone cancer, bronchial tumors, Burkitt lymphoma, non-Hodgkin lymphoma, carcinoid tumor (gastrointestinal), cardiac tumors, cervical cancer, cholangiocarcinoma, chordoma, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), colorectal cancer, craniopharyngioma, cutaneous T-cell lymphoma, ductal carcinoma in situ (DCIS), endometrial cancer, esophageal cancer, esthesioneuroblastoma, extragonadal germ cell tumor, eye cancer, intraocular melanoma, retinoblastoma, fallopian tube cancer, gallbladder cancer, gastric cancer, gastrointestinal carcinoid tumor, gastrointestinal stromal tumors (GIST), germ cell tumors, gestational trophoblastic disease, hairy cell leukemia, head and neck cancer, liver cancer, Hodgkin lymphoma, hypopharyngeal cancer, islet cell tumors, pancreatic neuroendocrine tumors, Langerhans cell histiocytosis, laryngeal cancer, leukemia, lip and oral cavity cancer, lung cancer, lymphoma, Merkel cell carcinoma, mesothelioma, plasma cell neoplasms, mycosis fungoides, myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, nasal cavity and paranasal sinus cancer, nasopharyngeal cancer, neuroblastoma, non-small cell lung cancer, oral cancer, oropharyngeal cancer, osteosarcoma, ovarian cancer, pancreatic cancer, paraganglioma, parathyroid cancer, penile cancer, multiple myeloma, prostate cancer, renal cell cancer, retinoblastoma, rhabdomyosarcoma, salivary gland cancer, sarcoma, uterine sarcoma, small cell lung cancer, small intestine cancer, soft tissue sarcoma, T-cell lymphoma, testicular cancer, throat cancer, thymoma, thyroid cancer, urethral cancer, uterine cancer, vaginal cancer, and Wilms tumor. 
     In certain embodiments of the first aspect, the lymph node metastasis is taken from a formalin-fixed, paraffin-embedded sample. In some embodiments, samples may be isolated from fine needle aspirates or fresh and/or frozen tissues. 
     In certain embodiments of the first aspect, the subject is a human. 
     In a second aspect of the invention, the invention provides a method for predicting outcome of locoregional control (LRC), relapse-free survival (RFS), and/or overall survival (OS) of a lymph node metastasis (LNM) in a subject, the method comprising:
         (a) obtaining a sample comprising LNM cells from the subject;   (b) measuring gene expression levels in the sample of at least ten genes selected from the group consisting of: TGFBR1, OLR1, PDGFC, ACE, MGA, PAPPA, APBB2, CARD19, SPDYE3, ACOT9, C1QTNF6, FAM153B, C10orf55, SLC25A33, KAT7, MUC20, ENTPD7, GOLT1B, PPRC1, ITPRIPL2, ZC3H12C, ARF4, COL27A1, ZNF850, VKORC1, RBM23, CAPG, TOR4A, METTL21B, TRMT2B, EVC, ZBTB14, PFDN1, FBXO25, B4GALT1, NTMT1, FAM227B, AGTRAP, RRAS, STRIP2, HECTD3, SH3BGRL2, LHFPL2, WHSC1L1, DCBLD1, SPRED1, BTBD18, FTSJ1, GSTO1, FAM102A, ZDHHC8, PDGFB, SDHAF4, PCBP4, HRH1, FMC1, FLNB, RPAIN, TAS2R4, TUBD1, FKBP14, METTL21A, TANC2, POLB, XKR4, ZNF19, NOX5, HBP1, C1orf56, KCNJ15, NDOR1, 43351, and PHACTR3;   (c) determining a LNM-specific molecular subtype comprising the gene expression levels of the at least ten genes; and   (d) providing an indication as to the outcome of LRC, RFS, and/or OS when the LNM-specific molecular subtype indicates that the expression levels of the at least ten genes are altered in a predictive manner.       

     In certain embodiments of the second aspect, the LNM-specific molecular subtype for the LNM is classified as Group 1, Group 2, or Group 3. In some methods, Group 1 indicates an immune subtype, Group 2 indicates a significantly worse LRC, RFS, and/or OS, and Group 3 indicates a metabolic/proliferative subtype. 
     As used herein, the term “local recurrence” or “LR” refers to recurrence of cancer cells at the primary tumor site and is calculated as the time to local or regional failure. In this context, local recurrence occurs when there is a failure in local control (LC) or local-only control, such that therapeutic intervention is not successful in the eradication of cancer at the primary tumor site. Local control or local-only control refers to the successful treatment of cancer at the primary tumor site. 
     As used herein, the term “locoregional recurrence” or “LRR” refers to recurrence of cancer cells in tissues immediately surrounding the primary tumor site and/or lymph nodes. Locoregional recurrence occurs when there is a failure of or decreased locoregional control (LRC), such that therapeutic intervention is not completely successful in the eradication of cancer in the tissues immediately surrounding the primary tumor site and/or lymph nodes. Locoregional control refers to the successful treatment of cancer in tissues immediately surrounding the primary tumor site and/or lymph nodes. Locoregional recurrences often suggest the development of refractory cancer that is resistant to chemotherapy and radiation therapy. In addition, locoregional recurrence can be difficult to control and/or treat if: (1) the primary tumor is located or involves a vital organ or structure that limits the potential for treatment; (2) recurrence after surgery or other therapy occurs, because while likely not a result from metastasis, high rates of recurrence indicate an advanced tumor; and (3) presence of lymph node metastases indicate advanced disease. 
     As used herein, the terms “relapse-free survival” (RFS) and “disease-free survival” (DFS) refer to the period after a successful cancer treatment during which the patient survives without any signs or symptoms of that cancer and can be calculated as the time to any failure or death from any cause. The relapse-free survival or disease-free survival rate is often stated as a five-year rate, which is the percentage of people in a study or treatment group who are relapse-free or disease-free five years after their diagnosis or start of treatment. 
     As used herein, “overall survival” (OS) refers to the percentage of people in a study or treatment group who are still alive for a certain period of time after they were diagnosed with or started treatment for a disease, such as cancer, and can be calculated as the time to death from any cause. The overall survival rate is often stated as a five-year survival rate, which is the percentage of people in a study or treatment group who are alive five years after their diagnosis or the start of treatment. 
     In certain embodiments of the second aspect, measuring gene expression levels of the at least ten genes comprises measurement by RNAseq, miRNAseq, RT-PCR, nanostring, or other hybridization detection methods, immunohistochemistry/Western blot analyses, nuclease protection assays, or Northern blot analyses. 
     In certain embodiments of the second aspect, the LNM cells from the subject are obtained from a primary cancer selected from the group consisting of: human papillomavirus-negative head and neck cancer, head and neck squamous cell cancer, breast cancer, melanoma, acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), adrenocortical carcinoma, kaposi sarcoma, aids-related lymphoma, primary CNS lymphoma, anal cancer, appendix cancer, astrocytomas, brain cancer, atypical teratoid/rhabdoid tumor, basal cell carcinoma of the skin, bile duct cancer, bladder cancer, bone cancer, bronchial tumors, Burkitt lymphoma, non-Hodgkin lymphoma, carcinoid tumor (gastrointestinal), cardiac tumors, cervical cancer, cholangiocarcinoma, chordoma, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), colorectal cancer, craniopharyngioma, cutaneous T-cell lymphoma, ductal carcinoma in situ (DCIS), endometrial cancer, esophageal cancer, esthesioneuroblastoma, extragonadal germ cell tumor, eye cancer, intraocular melanoma, retinoblastoma, fallopian tube cancer, gallbladder cancer, gastric cancer, gastrointestinal carcinoid tumor, gastrointestinal stromal tumors (GIST), germ cell tumors, gestational trophoblastic disease, hairy cell leukemia, head and neck cancer, liver cancer, Hodgkin lymphoma, hypopharyngeal cancer, islet cell tumors, pancreatic neuroendocrine tumors, Langerhans cell histiocytosis, laryngeal cancer, leukemia, lip and oral cavity cancer, lung cancer, lymphoma, Merkel cell carcinoma, mesothelioma, plasma cell neoplasms, mycosis fungoides, myelodysplastic syndromes, myelodysplastic/myeloproliferative neoplasms, nasal cavity and paranasal sinus cancer, nasopharyngeal cancer, neuroblastoma, non-small cell lung cancer, oral cancer, oropharyngeal cancer, osteosarcoma, ovarian cancer, pancreatic cancer, paraganglioma, parathyroid cancer, penile cancer, multiple myeloma, prostate cancer, renal cell cancer, retinoblastoma, rhabdomyosarcoma, salivary gland cancer, sarcoma, uterine sarcoma, small cell lung cancer, small intestine cancer, soft tissue sarcoma, T-cell lymphoma, testicular cancer, throat cancer, thymoma, thyroid cancer, urethral cancer, uterine cancer, vaginal cancer, and Wilms tumor. 
     As used herein, the terms “primary tumor” or “primary cancer” or “primary cancer tumor” can be used interchangeably and refer to the original, or first, tumor or cancer in the body of the patient. A primary tumor is a tumor growing at the anatomical site where tumor progression began and proceeded to yield a cancerous mass. Cancer cells from a primary tumor may spread (i.e., metastasize) to other parts of the body and form new, or secondary, tumors. Secondary tumors are the same type of cancer as the primary tumor. 
     As used herein, the term “metastasis” refers to the spread of cancer cells from its original, primary site to another, secondary part of the body. Metastasis is a complex process and depends on detachment of malignant cells from a primary tumor, invasion of the extracellular matrix, penetration of the endothelial basement membranes to enter the body cavity and vessels, and then, after being transported by the blood, infiltration of target organs. Finally, the growth of a new tumor at the target site depends on angiogenesis. In certain embodiments, the term “metastasis” can refer to “distant metastasis” which relates to a metastasis which is remote from the primary tumor and the regional lymph node system. 
     In certain embodiments of the first or second aspect, the lymph node metastasis is taken from a formalin-fixed, paraffin-embedded sample. In some embodiments, samples may be isolated from fine needle aspirates, or fresh frozen tissues. 
     In certain embodiments of the first or second aspect, the subject is a human. 
     The terms “increased expression” or “decreased expression” as used herein refer to an expression level of one or more genes, or prognostic RNA transcripts, or their corresponding cDNAs, or their expression product(s) that has been found differentially expressed in LNMs compared to a control (for example, control can refer to a low risk LNMs group). The higher the expression level of a gene which predominantly has increased expression in LNMs of patients who had recurrence, the higher is the likelihood that the patient suffering from this LNM is expected to have a poor clinical outcome (i.e., higher risk of recurrence, decreased overall survival, or both). In contrast, the lower the expression level of a gene which predominantly has increased expressed in LNMs of patients who have recurrent tumors, the higher is the likelihood that the patient suffering from this LNM is expected to have a promising clinical outcome (i.e., decreased risk of recurrence, increased overall survival, or both). The lower the expression level of a gene which predominantly has decreased expression in LNMs of patients who had recurrence, the higher is the likelihood that the patient suffering from this LNM is expected to have a poor clinical outcome (i.e., higher risk of recurrence, decreased overall survival, or both). In contrast, the higher the expression level of a gene which predominantly has decreased expressed in LNMs of patients who have recurrent tumors, the higher is the likelihood that the patient suffering from this LNM is expected to have a promising clinical outcome (i.e., decreased risk of recurrence, increased overall survival or both). 
     As used herein, the terms “control” or “normalized sample” can be based on one or more cancer samples that are not from the patient being tested. In certain embodiments, a cancer cell or tumor may be determined to have a relative increased or decreased level of expression by comparing the expression levels of genes in the sample from the patient to the median expression levels of these genes across all cancer patients. 
     As used herein, the terms “treatment,” “treat,” or “treating” generally refer to a method of reducing the effects of a disease or condition or symptom of the disease or condition. Thus, in the disclosed methods, treatment can refer to about a 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 100% reduction in the severity of an established disease or condition or symptom of the disease or condition. For example, a method of treating a disease is considered to be a treatment if there is about a 5% reduction in one or more symptoms of the disease in a subject as compared to a control. Thus, the reduction can be about a 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100% or any percent reduction between 5 and 100% as compared to native or control levels. It is understood that treatment does not necessarily refer to a cure or complete ablation of the disease, condition, or symptoms of the disease or condition. 
     As defined herein, the term “cancer treatment regimen” is determined by a medical professional or team of medical professionals and can be specific to each patient and/or cancer type, as is known in the art. Whether a treatment is aggressive or not will generally depend on the cancer-type, the age of the patient, etc. For example, in breast cancer adjuvant chemotherapy is a common aggressive treatment given to complement the less aggressive standards of surgery and hormonal therapy. Those skilled in the art are familiar with various other aggressive and less aggressive cancer treatment regimens for each type of cancer. A cancer treatment regimen is defined by the National Comprehensive Cancer Network (NCCN), and has been defined in the NCCN Guidelines® as including one or more of: 1) imaging (CT scan, PET/CT, MRI, chest X-ray), 2) discussion and/or offering of tumor resection if the tumor(s) is determined to be resectable, 3) radiation therapy (RT), 4) chemoradiation, 5) chemotherapy, 6) regional limb therapy, 7) palliative surgery, 8) systemic therapy, 9) immunotherapy, and 10) inclusion in ongoing clinical trials. Guidelines for clinical practice are published in the National Comprehensive Cancer Network (NCCN Guidelines® &amp; Clinical Resources, available on the World Wide Web at NCCN.org). NCCN guidelines for treatment of cancer are publically available for at least the following cancers: Acute Lymphoblastic Leukemia (both, adult and AYA), Acute Lymphoblastic Leukemia (pediatric), Acute Myeloid Leukemia, AIDS-Related Kaposi Sarcoma, Anal Carcinoma, Bladder Cancer, Bone Cancer, Breast Cancer, Central Nervous System Cancers, Cervical Cancer, Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Chronic Myeloid Leukemia, Colon Cancer, Rectal Cancer, Esophageal and Esophagogastric Junction Cancers, Gastric Cancer, Gestational Trophoblastic Neoplasia, Hairy Cell Leukemia, Head and Neck Cancers, Hepatobiliary Cancers, Hodgkin Lymphoma, Kidney Cancer, Malignant Pleural Mesothelioma, Melanoma, Cutaneous Melanoma, Uveal Melanoma, Multiple Myeloma, Systemic Light Chain Amyloidosis, Waldenström&#39;s Macroglobulinemia/Lymphoplasmacytic Lymphoma, Myelodysplastic Syndromes, Myeloproliferative Neoplasms, Neuroendocrine and Adrenal Tumors, Non-Hodgkin&#39;s Lymphomas, B-Cell Lymphomas, Primary Cutaneous Lymphomas, T-Cell Lymphomas, Non-Melanoma Skin Cancers (Basal Cell Skin Cancer, Dermatofibrosarcoma Protuberans, Merkel Cell Carcinoma, Squamous Cell Skin Cancer), Non-Small Cell Lung Cancer, Occult Primary, Ovarian Cancer, Pancreatic Adenocarcinoma, Penile Cancer, Prostate Cancer, Small Cell Lung Cancer, Soft Tissue Sarcoma, Systemic Mastocytosis, Testicular Cancer, Thymomas and Thymic Carcinomas, Thyroid Carcinoma, Uterine Neoplasms, and Vulvar Cancer. 
     The LNM-specific classifiers disclosed herein provide a new tool for cancer treatment that provides clinically relevant information that can be used to tailor conventional therapeutic intervention (e.g., surgery, radiation, chemotherapy, immunotherapy, and/or hormone therapy, etc.) to an individual&#39;s specific needs. For example, individuals identified with Group 2 LNMs can receive an aggressive treatment regimen immediately to maximize potential treatment efficacy. Similarly, individuals with either Group 1 or Group 3 LNMs may be able to receive effective but less aggressive treatments, which can lead to a less disruptive treatment experience for such individuals, as well as their families and friends. 
     In certain embodiments, the disclosed methods can be used to identify and treat patients that will benefit from a more aggressive cancer treatment regimen or less aggressive cancer treatment regimen. For example, if a patient is determined to have an aggressive form (Group 2) of a head and neck squamous cell cancer, then the patient can be selected for a more aggressive cancer treatment regimen with more frequent monitoring. In contrast, if a patient is determined to have a less aggressive form (Group 1 or Group 3) of a head and neck squamous cell cancer, then the patient can be selected for a less aggressive cancer treatment regimen with less frequent monitoring. Thus, in some embodiments, the disclosed methods further include selecting and treating a patient for more or less aggressive cancer treatment regimens and/or monitoring, depending on the expression levels detected of the at least ten genes. 
     In certain embodiments, a less aggressive cancer treatment regimen can comprise selecting and administering a single therapy instead of a dual therapy. In certain embodiments, a less aggressive cancer treatment regimen can comprise selecting and administering a dual therapy instead of a triple therapy. In certain embodiments, a more aggressive cancer treatment regimen can comprise, for example, selecting and administering a triple therapy instead of a dual therapy. In certain embodiments, a more aggressive cancer treatment can comprise, for example, selecting and administering more potent drugs and/or treatments or drugs and/or treatments at higher doses. In certain embodiments, a less aggressive cancer treatment regimen can comprise, for example, selecting and administering a dual therapy instead of a triple therapy, and selecting and administering less potent drugs, a decreasing drug dosage, a decreasing dose schedule, and/or a shortening length of treatment. 
     In certain embodiments, the methods of treatment further comprise administering to the patient one or more of a chemotherapy, a radiation therapy, and/or an immunotherapy. In certain embodiments, the method further comprises a second surgery for additional removal of the primary cancer and/or a secondary tumor. 
     In certain embodiments, surgery can be used to treat the cancer. Surgery can include resection of all or part of cancerous tissue. Tumor resection refers to physical removal, excision, and/or destruction of at least part of a tumor. In addition to tumor resection, treatment by surgery includes laser surgery, cryosurgery, electrosurgery, and microscopically controlled surgery (e.g., Mohs&#39; surgery). It is further contemplated that the treatment methods described herein may be used in conjunction with removal of superficial cancers, precancers, or incidental amounts of normal tissue. 
     Cancer treatment regimens envisioned herein include those known in the art. Therapeutic options may include, but are not limited to: 1) combination regimens such as: AD (doxorubicin, dacarbazine); AIM (doxorubicin, ifosfamide, mesna); MAID (mesna, doxorubicin, ifosfamide, dacarbazine); ifosfamide, epirubicin, mesna; gemcitabine and docetaxel; gemcitabine and vinorelbine; gemcitabine and dacarbazine; doxorubicin and olaratumab; methotrexate and vinblastine; tamoxifen and sulindac; vincristine, dactinomycin, cyclophosphamide; vincristine, doxorubicin, cyclophosphamide; vincristine, doxorubicin, cyclophosphamide with ifosfamide and etoposide; vincristine, doxorubicin, ifosfamide; cyclophosphamide topotecan; ifosfamide, doxorubicin; and/or 2) single agents, such as, cisplatin or other metallic compounds, 5-FU/capecitabine (Xeloda®), cetuximab (Erbitux®), pembrolizumab (MK-3475), panitumumab (Vectibix®), dacomitinib (PF-00299804), gefitinib (ZD1839, Iressa), doxorubicin, ifosfamide, epirubicin, gemcitabine, dacarbazine, temozolomide, vinorelbine, eribulin, trabectedin, pazopanib, imatinib, sunitinib, regorafenib, sorafenib, nilotinib, dasatinib, interferon, toremifene, methotrexate, irinotecan, topotecan, paclitaxel, nab-paclitaxel (abraxane), docetaxel, bevacizumab, temozolomide, sirolimus (Rapamune®), everolimus, temsirolimus, crizotinib, ceritinib, and palbociclib. 
     Additional contemplated cancer treatment regimens useful herein include those disclosed in U.S. Patent Application Publication No. US2016/0333355, which is incorporated by reference herein. For example, a treatment regimen may include administering an antineoplastic agent (e.g., chemotherapy) along with IR (or radiotherapy) to treat a resistant cancer cell. An illustrative antineoplastic agent or chemotherapeutic agent includes, for example, a standard taxane. Taxanes are produced by the plants of the genus  Taxus  and are classified as diterpenes and widely uses as chemotherapy agents including, for example, paclitaxel, (Taxol™, Bristol-Meyers Squibb, CAS 33069-62-4) and docetaxel (Taxotere™, Sanofi-Aventis, CAS 114977-28-5). Other chemotherapeutic agents include semi-synthetic derivatives of a natural taxoid such as cabazitaxel (Jevtana™, Sanofi-Aventis, CAS 183133-96-2). Other chemotherapeutic agents also include an androgen receptor inhibitor or mediator. Illustrative androgen receptor inhibitors include, a steroidal antiandrogen (for example, cyperterone, CAS 2098-66-0); a non-steroidal antiandrogen (for example, flutamide, Eulexin™, Schering-Plough, CAS 13311-84-7); nilutamide (Nilandron™, CAS 63612-50-0); enzalutamide (Xtandi™, Medivation™, CAS 915087-33-1); bicalutamide (Casodex, AstraZeneca, CAS 90357-06-5); a peptide antiandrogen; a small molecule antiandrogen (for example, RU58642 (Roussel-Uclaf S A, CAS 143782-63-2); LG120907 and LG105 (Ligand Pharmaceuticals); RD162 (Medivation™, CAS 915087-27-3); BMS-641988 (Bristol-Meyers Squibb, CAS 573738-99-5); and CH5137291 (Chugai Pharmaceutical Co. Ltd., CAS 104344603904)); a natural antiandrogen (for example, ataric acid (CAS 4707-47-5) and N-butylbensensulfonamide (CAS 3622-84-2); a selective androgen receptor modulator (for example, enobosarm (Ostarine™ Merck &amp; Company, CAS 841205-47-8); BMS-564,929 (Bristol-Meyer Squibb, CAS 627530-84-1); LGD-4033 (CAS 115910-22-4); AC-262,356 (Acadia Pharmaceuticals); LGD-3303 (Ganolix Lifescience Co., Ltd., 9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo[3,2-f]quino-lin-7(6H)-one; S-40503, Kaken Pharmaceuticals, 2-[4-(dimethylamino)-6-nitro-1,2,3,4-tetrahydroquinolin-2-yl]-2-methylpro-pan-1-ol); andarine (GTx-007, S-4, GTX, Inc., CAS 401900-40-1); and S-23 (GTX, Inc., (25)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide)); or those described in U.S. Patent Application No. 2009/0304663. Other neoplastic agents or chemotherapeutic agents that may be used include, for example: alkylating agents such as nitrogen mustards such as mechlorethamine (HN 2 ), cyclophosphamide, ifosfamide, melphalan (L-sarcolysin) and chlorambucil; ethylenimines and methylmelamines such as hexamethylmelamine, thiotepa; alkyl sulphonates such as busulfan; nitrosoureas such as carmustine (BCNU), lomustine (CCNU), semustine (methyl-CCNU) and streptozocin (streptozotocin); and triazenes such as decarbazine (DTIC; dimethyltriazenoimidazole-carboxamide); antimetabolites including folic acid analogues such as methotrexate (amethopterin); pyrimidine analogues such as fluorouracil (5-fluorouracil; 5-FU), floxuridine (fluorodeoxyuridine; FUdR) and cytarabine (cytosine arabinoside); and purine analogues and related inhibitors such as mercaptopurine (6-mercaptopurine; 6-MP), thioguanine (6-thioguanine; TG) and pentostatin (2′-deoxycoformycin); natural products including  vinca  alkaloids such as vinblastine (VLB) and vincristine; epipodophyllotoxins such as etoposide and teniposide; antibiotics such as dactinomycin (actinomycin D), daunorubicin (daunomycin; rubidomycin), doxorubicin, bleomycin, plicamycin (mithramycin) and mitomycin (mitomycin C); enzymes such as L-asparaginase; biological response modifiers such as interferon alphenomes; other agents such as platinum coordination complexes such as cisplatin (cis-DDP) and carboplatin; anthracenedione such as mitoxantrone and anthracycline; substituted urea such as hydroxyurea; methyl hydrazine derivative such as procarbazine (N-methylhydrazine, MTH); adrenocortical suppressant such as mitotane (o,p′-DDD) and aminoglutethimide; taxol analogues/derivatives; hormone agonists/antagonists such as flutamide and tamoxifen; and GnRH and analogues thereof. Examples of other chemotherapeutic can be found in Cancer Principles and Practice of Oncology by V. T. Devita and S. Hellman (editors), 6 th  edition (Feb. 15, 2001), Lippincott Williams &amp; Wilkins Publishers. 
     In certain embodiments, a radiation therapy can be used. Radiation therapy (also known as radiotherapy) uses high doses of radiation to kill cancer cells and shrink tumors. Dosage ranges for X-rays can range from daily doses of 50 to 200 roentgens for prolonged periods of time (3 to 4 weeks), to single doses of 2000 to 6000 roentgens. Dosage ranges for radioisotopes vary widely, and depend on the half-life of the isotope, the strength and type of radiation emitted, and the uptake by the neoplastic cells. Different routes of administration of radiation therapy contemplated herein are familiar to the person of ordinary skill in the art. 
     Radiotherapy is based on ionizing radiation delivered to a target area that results in death of reproductive tumor cells. Some examples of radiotherapy include the radiation of cesium, palladium, iridium, iodine, or cobalt which is usually delivered as ionizing radiation delivered from a linear accelerator or an isotopic source such as a cobalt source. Also variations on linear accelerators are Cyberkine and Tomotherapy. Particle radiotherapy from cyclotrons such as Protons or Carbon nuclei may be employed. Also radioisotopes delivered systemically such as P32 or radium 223 may be used. The external radiotherapy may be systemic radiation in the form of stereotactic radiotherapy, total nodal radiotherapy, or whole body radiotherapy but is more likely focused to a particular site, such as the location of the tumor or the solid cancer tissues (for example, abdomen, lung, liver, lymph nodes, head, etc.). The radiation dosage regimen is generally defined in terms of Gray or Sieverts time and fractionation, and must be carefully defined by the radiation oncologist. The amount of radiation a subject receives will depend on various consideration but the two important considerations are the location of the tumor in relation to other critical structures or organs of the body, and the extent to which the tumor has spread. One illustrative course of treatment for a subject undergoing radiation therapy is a treatment schedule over a 5 to 8 week period, with a total dose of 50 to 80 Gray (Gy) administered to the subject in a single daily fraction of 1.8 to 2.0 Gy, 5 days a week. A Gy is an abbreviation for Gray and refers to 100 rad of dose. 
     Radiotherapy can also include implanting radioactive seeds inside or next to a site designated for radiotherapy and is termed brachytherapy (or internal radiotherapy, endocurietherapy or sealed source therapy). For prostate cancer, there are currently two types of brachytherapy: permanent and temporary. In permanent brachytherapy, radioactive (iodine-125 or palladium-103) seeds are implanted into the prostate gland using an ultrasound for guidance. Illustratively, about 40 to 100 seeds are implanted and the number and placement are generally determined by a computer-generated treatment plan known in the art specific for each subject. Temporary brachytherapy uses a hollow source placed into the prostate gland that is filled with radioactive material (iridium-192) for about 5 to about 15 minutes, for example. Following treatment, the needle and radioactive material are removed. This procedure is repeated two to three times over a course of several days. 
     Radiotherapy can also include radiation delivered by external beam radiation therapy (EBRT), including, for example, a linear accelerator (a type of high-powered X-ray machine that produces very powerful photons that penetrate deep into the body); proton beam therapy where photons are derived from a radioactive source such as iridium-192, caesium-137, radium-226 (no longer used clinically), or cobalt-60; Hadron therapy; multi-leaf collimator (MLC); and intensity modulated radiation therapy (IMRT). During this type of therapy, a brief exposure to the radiation is given for a duration of several minutes, and treatment is typically given once per day, 5 days per week, for about 5 to 8 weeks. No radiation remains in the subject after treatment. There are several ways to deliver EBRT, including, for example, three-dimensional conformal radiation therapy where the beam intensity of each beam is determined by the shape of the tumor. Illustrative dosages used for photon based radiation is measured in Gy, and in an otherwise healthy subject (that is, little or no other disease states present such as high blood pressure, infection, diabetes, etc.) for a solid epithelial tumor ranges from about 60 to about 80 Gy, and for a lymphoma ranges from about 20 to about 40 Gy. Illustrative preventative (adjuvant) doses are typically given at about 45 to about 60 Gy in about 1.8 to about 2 Gy fractions for breast, head, and neck cancers. 
     When radiation therapy is a local modality, radiation therapy as a single line of therapy is unlikely to provide a cure for those tumors that have metastasized distantly outside the zone of treatment. Thus, the use of radiation therapy with other modality regimens, including chemotherapy, has important beneficial effects for the treatment of metastasized cancers. 
     Radiation therapy has also been combined temporally with chemotherapy to improve the outcome of treatment. For example, radiation therapy and chemotherapy can be administered sequentially (e.g., administration of chemotherapy and radiation therapy separately in time or concomitantly (e.g., administration of chemotherapy and radiation therapy on the same day. Also, radiation therapy and chemotherapy can be administered alternately, (e.g., administration of radiation therapy on the days when chemotherapy is not administered). It should be noted that other therapeutically effective doses of radiotherapy can be determined by a radiation oncologist skilled in the art and can be based on, for example, whether the subject is receiving chemotherapy, if the radiation is given before or after surgery, the type and/or stage of cancer, the location of the tumor, and the age, weight and general health of the subject. 
     In certain embodiments, immunotherapies can also be used to treat the cancer. Immunotherapy typically refers to the use of immune effector cells and/or molecules to target and destroy cancer cells. An immune effector molecule may be, for example, an antibody specific for some marker on the surface of a tumor cell. The antibody alone may serve as an effector of therapy or it may recruit other cells (e.g., immune cells) to effect cancer cell killing. The antibody also may be conjugated to a drug and/or toxin (e.g., a chemotherapeutic, a radionuclide, a ricin A chain, a cholera toxin, a pertussis toxin, etc.) and serve merely as a targeting agent. Alternatively, the effector may be an immune effector cell, such as a lymphocyte carrying a surface molecule that interacts, either directly or indirectly, with a tumor cell target. Various effector cells include cytotoxic T cells and NK cells. 
     Examples of immunotherapies (that can be used alone or in combination with any one or more of tumor resection if a tumor is determined to be resectable, radiation therapy, chemoradiation, chemotherapy, systemic therapy, additional immunotherapeutic, or inclusion in ongoing clinical trials), can include, for example, pembrolizumab (Keytruda®) and nivolumab (Opdivo®), cemiplimab (REGN2810; a fully human monoclonal antibody to Programmed Death-1), or other PD-1 inhibitors. CTLA-4 inhibitors (for example, ipilimumab (Yervoy®)) are another class of drugs that can boost the immune response. In some instances, cytokine therapy (such as, interferon-alpha and/or interleukin-2) can be used to boost the immune system. Examples of interferon and interleukin-based treatments can include, but are not limited to, aldesleukin (Proleukin®), interferon alpha-2b (INTRON®), and pegylated interferon alpha-2b (Sylvatron®; PEG-INTRON®, PEGASYS). In another embodiment, oncolytic virus therapy can be used. Along with killing the cells directly, the oncolytic viruses can also alert the immune system to attack the cancer cells. For example, talimogene laherparepvec (Imlygic®), also known as T-VEC, is an oncolytic virus that can be used to treat melanomas. Additional immunotherapies may include CV8102. 
     Examples 
     The Examples that follow are illustrative of specific embodiments of the invention, and various uses thereof. They are set forth for explanatory purposes only and are not taken as limiting the invention. 
     Purpose: In advanced stage head and neck squamous cell cancers (HNSCCs), approximately half of the patients with lymph node metastases (LNMs) are not cured. Given the heterogeneous outcomes in these patients, the expression patterns of LNMs were profiled to identify the biological factors associated with patient outcomes. 
     Experimental design: mRNAseq and miRNAseq was performed on 72 LNMs and 29 matched primary tumors from 34 HNSCCs patients. Unsupervised clustering identified molecular subtypes in LNMs and in matched primary tumors. Prediction Analysis of Microarrays identified a 73 gene classifier that distinguished LNM-subtypes. Gene Set Enrichment Analysis identified pathways upregulated in distinct LNMs subtypes. 
     Results: Integrative clustering identified 3 distinct LNMs subtypes: (i) an immune subtype (Group 1), (ii) an invasive subtype (Group 2) and (iii) a metabolic/proliferative subtype (Group 3). Group 2 subtype was associated with significantly worse locoregional control and survival. LNM-specific subtypes were not observed in matched primary tumor specimens. In HNSCCs, breast cancers and melanomas, a 73-gene classifier identified similar Group 2 LNMs subtypes that were associated with worse disease control and survival only when applied to lymph node sites, but not when applied to other primary tumors or metastatic sites. Similarly, previously proposed prognostic classifiers better distinguished patients with worse outcomes when applied to the transcriptional profiles of LNMs, but not the profiles of primary tumors. 
     Data Interpretation: The transcriptional profiles of LNMs better predict outcomes than transcriptional profiles of primary tumors. The LNMs display site-specific subtypes associated with worse disease control and survival across multiple cancer types 
     Methods 
     Patient population: From a database of non-metastatic HNSCC (6), 34 patients were identified with pathologic lymph node positive HNSCC treated with post-operative radiotherapy at University of Illinois between Mar. 26, 2001 and Mar. 31, 2013 (UIC HNSCC dataset;  FIG. 7 ). The IRB waived informed consent due to the difficulty in obtaining consent of patients with archived pathological specimens. Patients were excluded due to Stage I-II disease (n=131), treatment with definitive radiation and/or did not have a therapeutic lymph node dissection prior to radiotherapy (n=352), no pathologically involved lymph nodes on dissection (n=89), no pathological accession numbers and/or tissue blocks were not available (n=79). The remaining 9 patients were excluded due to poor sequencing quality (n=8) or the presence of HPV16 transcripts (n=1). The resulting dataset is referred to as UIC HNSCC dataset. Biospecimens and de-identified linked patient data were collected in accordance with University of Illinois at Chicago Institutional Review Board guidelines (IRB 2011-1075). Data analysis was performed in accordance with University of Illinois at Chicago and University of Chicago (IRB 2015-1008) Institutional Review Board guidelines. 
     Clinical variables and analyses: Follow-up was calculated from the completion of radiotherapy to the date of first failure or last follow-up. Margin status, perineural invasion, lymphovascular space invasion, extracapsular extension, number of positive lymph nodes and number of lymph nodes dissected were based on the final pathology report. Treatment package time was calculated as the time from ablative surgery to the last day of radiotherapy. Events were determined from the last day of radiotherapy. Patterns of local (LF), regional (RF) or distant failure (DF) were documented as sites of first failure. Locoregional control (LRC) was calculated as the time to local or regional failure. Relapse-free survival (RFS) was calculated as the time to any failure or death from any cause. Overall survival (OS) was calculated as the time to death from any cause. 
     Statistical analysis was performed using JMP version 9 (SAS Institute). All tests of statistical significance were two-sided, and significance was defined as P&lt;0.05. The chi-square test was used to compare between discrete variables and t-test between continuous variables. Differences between medians were assessed using the Wilcoxon test. Survival analysis was performed for all patients. Censoring was non-informative. All events were calculated using Kaplan Meier models with log-rank test, and the differences were compared using Cox regression models. For univariate analysis (UVA), factors known to impact oncologic outcomes were selected as well as patient and treatment characteristics. Cox proportional hazards model were used to examine the effects of these different risk factors on event outcomes for LRC. Cox multivariable analysis (MVA) was performed to adjust for explanatory confounding variables prognostic on UVA. Patient characteristics that were not recorded were not included during statistical analysis. Detailed description of patient and clinical variables are contained in Supplementary Information. 
     Sample isolation, Sequencing, and Analysis: Archived formalin fixed paraffin embedded (FFPE) tissue blocks of LNMs and matched primary tumors with the corresponding H&amp;E slide were analyzed by expert head and neck pathologists (O.D. &amp; R.J.C.). The area of greatest density of tumor cells with at least 70% cancer cells were identified on the H&amp;E slide and mapped to the corresponding FFPE block. 2 mm punch biopsies were obtained for the indicated region. RNA was extracted from isolated specimens using the RecoverAll Total Nucleic Acid Isolation Kit (Ambion, TX) and stored at −80° C. until further analysis. mRNA and miRNA libraries were sequenced on a HiSEQ2500 machine using standard reagents and protocols provided by Illumina. Read alignment, quantification, and normalization are described in the Supplementary Information. 
     Detection of Differentially Expressed mRNAs or miRNAs: To identify differentially expressed mRNAs among samples grouped by iCluster method, heteroscedascity was removed from the normalized CPM data using the voomWithQualityWeights function from the limma package. A linear model for each gene was fit using the limma algorithm, adjusted for patient covariate, and ranked the genes for differential expression using the empirical Bayes method with robust option enabled. For miRNAs, the limma method was applied to identify differentially expressed miRNAs among the samples grouped by iCluster method. First the relative quality weights were estimated for each array using the arrayWeightsSimple function, and then a linear model was fit for each probeset adjusted for batch effect, followed by ranking probesets for differential expression using empirical Bayes method. The differentially expressed genes were identified with the Benjamini-Hochberg procedure for multiple testing adjustment and fold-change. The false discovery rate (FDR) controlling adjusted P-value and fold-change threshold were set at 0.05 and 1.5 for mRNAs and 0.1 and 1.5 for miRNAs, respectively. 
     Clustering analysis with iCluster+: An integrative clustering method named iCluster+ (19) was applied to the matched mRNA and miRNA expression data of the lymph node samples alone and primary tumor and lymph node samples combined. The algorithm was run for N=2 to 6 with the number of lambda as 144. For each N, a model that contains a deviance ratio metric was obtained. The metric was selected based on minimum Bayesian information criterion (BIC) for each lambda value, and can be interpreted as the percentage of total variation explained by the current model. The optimal number of clusters N was determined at the point when increasing N, the percent explained variation no longer significantly increases. Consensus clustering is described in the Supplementary Information. 
     Functional enrichment analysis: Raw gene feature counts were mapped to Entrez ID using the R/Bioconductor package org.Hs.eg.db v3.5.0. Low/non-expressed genes with less than 1 CPM across the minimum number of samples in any icluster group were excluded from subsequent analysis using edgeR. Quality weighted, TMM normalized, and log 2-transformed CPM were calculated using limma-voom (version 3.34.5). Gene set enrichment was performed with planned contrasts of one iCluster group against the remaining groups using GSEA (20) for comparison within the UIC HNSCC dataset or the R/Bioconductor package EGSEA (version 1.6.1) (21) for comparison across other publically available including HNSCC (16) (Array Express E-MEXP-44), breast cancer (22) (GSE56493) and melanoma (23) (Array Express E-GEOD-65904) databases. Independent GSEA/EGSEA analyses were performed for gene lists provided by MSigDB v5.2 containing hallmark gene set and KEGG pathway gene set. Enriched pathways were selected according to the median rank across 12 enrichment methods implemented in the package. 
     Classification—Data Preprocessing, Training and Testing: To build a classifier to distinguish samples between cluster 2 (C2) and cluster 1 and 3 combined (C13) identified by iCluster method, the normalized mRNA expression data of 33 patients was split into a training set, consisting of 22 cluster 2 samples and 33 cluster 1 and 3 samples, and a test set, consisting of 7 cluster 2 samples and 11 cluster 1 and 3 samples. The class ratio remained unchanged during the partition. For the training set, first genes were filtered with near zero-variance. Then highly correlated genes were identified with a pair-wise absolute correlation coefficient greater than 0.75, and those with the largest mean absolute correlation were removed. Potential linear dependencies of the data were also removed using the findLinearCombos function from the R package Caret (version 6.0). The preProcess function was applied to center and scale the training and test data by mean and standard deviation, followed by rescaling data to −1 and 1. Prediction Analysis of Microarrays (PAMR, version 1.55) was also applied—a nearest shrunken centroid classification algorithm—on the training set (24). A 10-fold cross-validation was performed to obtain the optimal threshold of 2.536 for the prediction, where the overall error rate was 0.091. The final classification model contains 73 genes and was evaluated using the held-out test data of 7 group two samples and 11 group one and three samples. Performance metrics such as accuracy, balanced accuracy, sensitivity, specificity, positive prediction value (PPV), negative prediction value (NPV), Cohen&#39;s Kappa, Matthew&#39;s correlation coefficient (MCC), and area under the curve (AUC) were calculated using the confusionMatrix function from the Caret package and an in-house script. 
     Independent Validation of Classifier: To evaluate the LNM classifier performance in other tumor types, lymph node metastatic tumor expression data were collected from three published studies. The studies contain microarray expression data from breast cancer (22) (GSE56493), melanoma (23) (GSE65904, 10000 most variable genes), and HNSCCs (16) (MDACC HNSCC dataset; E-TABM-114) from Gene Expression Omnibus (GEO) and ArrayExpress database. For each dataset, the normalized gene expression data was downloaded from the original studies. The probesets (Affymetrix) or probes (Illumina) were converted to Ensembl gene identifiers. The expression data of the 73 genes were scaled to −1 and 1. Values for the missing genes were set to −1. The LNM classifier was then applied to the data to predict the test samples as group two or group one and three combined. 
     Comparison of the LNM classifier and other published signatures: The LNM classifier&#39;s ability of distinguishing different survival group in HNSCC patients was evaluated with the comparison of four published gene signatures (25-28). For each signature, the gene signatures was collected from the original publication and converted the gene symbol or alias to Ensembl gene identifier, then computed the score based the gene expression in our data set. The following criteria was used to group the patients into two risk groups and performed the Kaplan-Meier survival estimates for the risk groups. 
     (1) Enokida classifier: PI&gt;75 quartile—PI high, otherwise—PI low 
     (2) RSI classifier: RSI&lt;median—Responder, otherwise—Non-responder 
     (3) 13 OSCC classifier: RS&gt;median—High risk, otherwise—Low risk 
     (4) 172-gene classifier: RS&gt;mean—High risk, otherwise—Low risk 
     Supplementary Information 
     Patient and clinical variables: Patient comorbidity burden was approximated using the Charlson Comorbidity Index. 1  Performance status was assessed using the Karnofsky Performance Status (KPS). 2  Patients were staged according to the American Joint Committee on Cancer staging system at the time of diagnosis. Documentation of race was based on patients self-reporting on clinic or hospital intake sheets. Alcohol history was defined as ≥ or &lt;2 alcoholic drinks per day. Smoking was defined as ≥ or &lt;10 pack-years. 
     Library Construction: RNA integrity and quantity were evaluated using an Agilent 2100 Bioanalyzer (Agilent Technologies, CA). Reverse-stranded single-end 50 base-pair sequencing libraries were constructed using Illumina Total RNA Stranded Kits. Ribosomal RNAs (rRNAs) were depleted by using the Ribo-Zero rRNA Removal Kit (Illumina). Libraries were sequenced on a HiSEQ2500 machine using standard reagents and protocols provided by Illumina. 
     Read Alignment and Quantification: Unless otherwise specified, all data analyses were performed under the R programming and software environment for statistical computing and graphics version 3.4 (R Core Team, 2016). FastQ file for each sample was assessed for quality using the FastQC tool (version 0.11.2). For mRNAseq, raw reads were aligned to the GRCh38 primary genome assembly using Spliced Transcripts Alignment to a Reference (STAR) aligner (version 2.4.2a) 1-pass algorithm. After sorting the bam files in lexicographical order with the sambamba program3, the reads were assigned to exon features annotated in GENCODE (release 25) using the FeatureCounts tool from the subread package (version 1.4.6) and summarized the read counts by genes. The post-alignment quality control was carried out with Picard tools (version 1.117) and RSeQC package (version 2.3.1). Specifically, the QC data regarding the alignment summary, gene body coverage, read distribution, and ribosomal RNA depletion rate was examined. Alignment-free transcriptome quantification method Salmon (version 0.8.2) 3  was used to estimate the transcript abundance of each sample. Then the transcript-level estimates for gene-level analysis was summarized using R/Bioconductor package tximport 4  and GENCODE annotation (release 25). For miRNAseq, cutadapt (version 1.7) was used with the following parameter setting (-a TGGAATTCTCGG-O 3-m 17-q 20; (SEQ ID NO:88)) to remove adapter sequences and reads with low base calling quality score. Mapper module from miRDeep (version 2.0.0.8) 5  was applied to convert trimmed reads to FASTA files and quantifier module to quantify the expression based on the predefined human miRNA precursors mature and hairpin miRNA sequences (miRBase 21). 
     Data Normalization: After removing the genes with zero read counts across all samples, the normalization factors were calculated to scale the raw library sizes using the calcNormFactors function in the edgeR package (v3.20.6) with trimmed mean of M-values (TMM) option enabled 6 . The normalized count per million (CPM) value was log 2-transformed for each gene. The log-CPM values were corrected for batch effect (sequencing lane effect) if needed, using removeBatchEffect function from the R/Bioconductor package limma (version 3.34.9). 
     Reference samples were developed to normalize samples when measuring the 73-gene signature. The list of genes to generate the reference sample is shown in Table 7. The reference oligomers (SEQ ID NOs:1-87) were synthesized at 4 nM, and resuspended at a stock concentration of 10 pmol/microliter. A batch reference sample was generated with all oligomers at a concentration of 100 fmol/microliter. The nanostring cassette detected oligomers at a concentration of 500 fmol to 8 fmol. Reference concentrations of 31.2 fmol to 125 fmol were chosen for the assay. 
     Consensus Clustering of Expression Data: To evaluate if a selected set of DEGs or DEmiRs between iCluster groups alone could identify patients with distinct survival outcomes, consensus clustering analysis was performed on mRNA and miRNA expression data sets using the R package ConsensusClusterPlus (version 1.38.0) 8 . The DEGs and the DEmiRs were selected across three iCluster groups, respectively. Normalized expression data from previous procedures were first standardized using the data normalization function in the R package clusterSim (version 0.45-1). To run ConsensusClusterPlus, the options were preset as a maximum evaluated cluster k=6, 80% samples per resampling, 1,000 resamplings, Euclidean distance, and k-means clustering algorithm. Complete and average linkage were chosen as the inner-linkage and final linkage, respectively. The optimal number of k clusters was inferred by inspecting the consensus cumulative distribution function (CDF) plot and the proportion of ambiguously clustered pairs (PAC) 9  plot where the optimal k corresponds to the lowest PAC. 
     Example No. 1. Integrative Analysis of LNMs Identified Three Molecular Subtypes Associated with Different Rates of HNSCC Recurrence 
     Thirty four patients were identified with human papillomavirus (HPV)-negative HNSCC who had accessible primary tumors and matched LNMs (6). These patients were treated with surgical resection of the primary tumor and lymph node dissection followed by radiotherapy with or without chemotherapy ( FIG. 1A ). Since differences in coding and non-coding gene expression may distinguish clinically relevant subtypes in LNMs, RNAseq and miRNAseq was performed on 29 tumors and 72 matched LNM (termed UIC HNSCC dataset). Table 1 lists the clinicopathological characteristics of this group where the majority of patients had N2-N3 disease (81.8%) and received post-operative chemoradiation (78.8%). The 2 year LRC, PFS, and OS in the entire cohort was 66.7%, 55.1%, and 52.7%, respectively, similar to previous reported outcomes in HPV-negative HNSCCs (11, 12) ( FIG. 8 ). 
     To identify distinct metastatic subtypes, integrative clustering was performed on the 72 LNMs in order to identify potential lymph node-specific subtypes. Integrative clustering identified 3 distinct molecular subtypes: 27 LNMs were classified as Group 1, 29 LNMs were classified as Group 2 and 16 LNMs were classified as Group 3. 
     The clinical relevance of the Group 1, Group 2, and Group 3 LNM subtypes was assessed by comparing clinicopathological variables, disease recurrence, and survival. Since 11 of 17 patients with multiple LNMs displayed more than one LNM subtype, patients with multiple LNMs were classified as Group 2 if patients had ≥2 Group 2 LNMs. If patients with multiple LNMs had &lt;2 Group 2 LNM, these patients were classified according the most prevalent LNM subtype. On univariate analysis, patients with Group 3 LNMs were associated with greater lymphovascular space invasion (P=0.02), and patients with Group 2 LNMs were associated with fewer numbers of LN removed at the time of surgery (P=0.03; Table 2). Patients with Group 2 LNMs displayed significantly worse LRC (ly LRC Group 1: 91.7% vs. Group 2: 0.0% vs. Group 3: 72.9%; P=0.002), RFS (P=0.002), and OS (ly OS Group 1: 92.9% vs. Group 2: 44.4% vs. Group 3: 100.0%; P=0.02;  FIGS. 1B-1D  and  FIG. 9 ). On multivariate analyses, Group 2 subtype remained the only predictor for LRC compared to either the Group 1 subtype (HR: 0.1; 95% CI 0.01-0.71; P=0.02) or the Group 3 subtype (HR: 0.2; 95% CI 0.03-0.99; P=0.04; Table 3). There was no difference in LRC between Group 1 and Group 3 subtypes (HR: 2.04; 95% CI 0.27-17.82; P=0.48). 
     The classification of these 3 molecular subtypes was primarily due to differences in mRNA expression and not miRNA expression. Using pair-wise comparisons, 2,039 differentially expressed mRNAs (DEmRNAs) were detected and 24 differentially expressed miRNAs (DEmiRNAs;  FIG. 1E ;  FIGS. 10A &amp; 10B , Table 4). Consensus clustering, consensus cumulative distribution function, and proportion of ambiguous clustering of DEmRNAs confirmed that 3 molecular subtypes were the optimal classification of LMNs ( FIGS. 1F-1H ). By contrast, consensus clustering of DEmRNAs using other predefined cluster numbers of K=2, 4, 5 or 6 exhibited less optimal cluster groupings ( FIG. 11 ). Furthermore, more than 3 pre-defined clusters failed to further stratify differences in LRC. Pre-defined clustering of DEmiRNAs did not identify any subtypes having differences in LRC ( FIGS. 10B-10G ). Therefore, molecular classification of LNMs in HPV-negative HNSCCs using DEmRNAs defined three distinct subtypes where one subtype, Group 2, had significantly worse LRC, RFS, and OS. 
     Example No. 2. The Group 2 LNM Subtype was Associated with an Invasive Subtype 
     Gene Set Enrichment Analysis (GSEA) was performed to better understand the distinct biological pathways characterizing the different LNMs subtypes ( FIG. 2  and  FIG. 12 ). The Group 2 LNM subtype was associated with pathways characterizing an invasive subtype with enriched pathways including epithelial mesenchymal transition, apical junction, TGF-β signaling, angiogenesis, hypoxia, extracellular matrix receptor interactions, regulation of the actin cytoskeleton, and focal adhesion. Group 1 was associated with pathways characterizing an immune subtype with enriched pathways including allograft rejection, T cell receptor signaling pathway, and chemokine receptor signaling pathway among others. Group 3 was associated with pathways characterizing a proliferative/metabolic subtype with enriched pathways including MYC targets, basal transcription factors, and mismatch repair. Of note, Group 1 and Group 3 often displayed an inverse pattern of enriched gene sets. By contrast, Group 2 differed from Group 1 and Group 3 primarily in gene sets involved in the cell membrane and the extracellular matrix. 
     Example No. 3. Lymph Node Subtypes were not Identified in the Primary Tumor 
     Previous reports in HNSCCs as well as in other cancers have demonstrated that the transcriptional profiles of LNMs were similar to the primary tumor (16, 17, 29, 30). Consequently, it was determined if unbiased classification methods would identify similar molecular subtypes in matched primary tumors. RNAseq and miRNAseq were performed on 29 matched primary tumors from patients with LNMs. Integrative clustering identified two molecular subtypes in primary tumors. However, these primary tumor subtypes, Tumor Group 1 and Tumor Group 2, did not differ in LRC (ly LRC: 63.5% for Tumor Group 1 vs. 64.0% for Tumor Group 2; P=0.92;  FIG. 3A ). Unlike LNMs, primary tumors did not have any DEmRNAs between groups, but there were 14 DEmiRNAs that confirmed the two subtypes as optimal stratification based on consensus clustering and proportion of ambiguous clusters ( FIGS. 3B and 3C ). Given that unbiased approaches did not identify similar molecular subtypes in primary tumors, supervised clustering of primary tumors was performed based on the DEmRNAs identified in the LNMs subtypes. Clustering based on the LNMs DEmRNAs identified 6 clusters that displayed similar rates of LRC ( FIGS. 3D-3G ). Consequently, the molecular subtypes identified in LNMs were not observed in the matched primary tumors. 
     Example No. 4. The Gene Expression Profiles of LNMs Better Predicted for Locoregional Control and Relapse-Free Survival 
     The ability to identify clinically relevant molecular subtypes in LNMs but not in primary tumors may reflect the biological selection of more aggressive subpopulations at the metastatic site. To determine if LNMs represented more aggressive variants, the ability of 4 prognostic HNSCC classifiers was assessed to predict locoregional control and relapse-free survival using the primary tumor or LNMs gene expression profiles. (1) a 172 gene signature derived from semi-supervised clustering and validated in a meta-analysis of 646 primary HNSCCs (25), (2) a 30 gene prognostic index (PI) derived from unsupervised clustering and validated in 123 primary oral cavity carcinomas (26), (3) a 10 gene radiosensitivity index (RSI) derived from a systems biology model and validated in 92 primary HNSCCs (27), and (4) 13-gene risk score derived from an L1-penalized Cox proportional hazard regression model were used and validated in 103 primary oral cavity cancers (28). When the primary tumor gene expression profiles were used in analysis, all 4 prognostic classifiers failed to stratify patients with worse LRC and 2 of 4 classifiers failed to stratify patients with worse RFS ( FIG. 4  and  FIG. 13 ). 
     By contrast, when the LNM gene expression profiles were used in analysis, 3 of the 4 classifiers stratified patients with worse LRC (173 gene signature P=0.04; 10 gene RSI P=0.02; 13 gene RS P=0.001) and all four classifiers stratified patients with worse RFS. Therefore, the gene expression profiles of LNMs better predicted outcomes than the gene expression profiles of primary tumors. 
     Example No. 5. Identification of a Lymph Node-Specific Group 2 Classifier that Predicts Outcomes Across Multiple Cancer Types 
     Previously published HNSCC prognostic signatures (25-28) were able to distinguish the aggressive Group 2 variant with 61.1% to 80.6% accuracy (Table 5). Consequently, classifiers developed from primary tumors to identify high risk subgroups may not adequately identify high risk subgroups in LNMs. A discovery set of 52 randomly selected LNMs were used to generate a nearest shrunken centroid-based 73 gene binary classifier that distinguished Group 2 LNMs from Group 1 and Group 3 LNMs (Group 1&amp;3; Table 6). Using the remaining 18 LNM specimens as a testing cohort, this 73 gene classifier had an accuracy of 0.89 (95% CI: 0.65-0.99; P=0.01) with a sensitivity of 1.00, specificity of 0.82, positive predictive value of 0.78 and negative predictive value of 1.00. The ROC plot of this 73 gene classifier had an AUC of 98.7% (95% CI 95.1% to 100.0%;  FIG. 14 ). As expected, the 73 gene LNMs classifier identified a clinically significant Group 2 subtype having worse LRC when applied to LNMs but not primary tumor specimens in the UIC HNSCC cohort ( FIG. 5A ). Next, the extent to which this 73 gene classifier predicted outcomes was assessed using the gene expression profiles from LNMs or non-LNMs in other cancers. A prospectively obtained breast cancer dataset (22) isolated from initial recurrences in LNMs (n=44), primary tumors (n=19), liver metastases (n=27), or other sites (n=30) was utilized. In addition, a dataset of retrospectively obtained melanoma specimens (23) isolated from the primary tumor (n=16), LNMs (n=139), distant metastases (n=23), in transit metastases (n=15) or local recurrences (n=11) was also utilized. Group 2 subtypes displayed worse overall survival and disease-specific survival when applied to the transcriptomes of breast and melanoma LNMs, respectively ( FIGS. 5B and 5C ). By contrast, when other non-LNM sites were analyzed, Group 2 subtypes were not associated with differences in outcomes consistent with our observations in HNSCC primary tumors. 
     To confirm that this 73 gene classifier identified a Group 2 LNM subtype, ensemble GSEA (EGSEA) was performed to identify pathways unregulated in Group 2 subtypes in breast cancer LNM (22), melanoma LNM (23) as well as in a small retrospective series of LNMs from the MDACC HNSCC cohort (16). Group 2 subtypes identified from UIC HNSCC, MDACC, HNSCC, breast, and melanoma cohorts had a significant degree of concordance (Hallmark W=0.67; P=3.2×10 −9 ; KEGG W=0.52; P=6.13×10 −16 ). Of the 49 shared Hallmark gene sets, the top 3 median ranked pathways were epithelial mesenchymal transition (median rank: UIC HNSCC 5, Breast 3.5, Melanoma 1 and MDACC HNSCC 2), coagulation (median rank: UIC HNSCC 2, Breast 5.5, Melanoma 6 and MDACC HNSCC 7.5), and hypoxia (median rank: UIC HNSCC 14.5, Breast 5, Melanoma 4 and MDACC HNSCC 4.5;  FIG. 6A ). In the 187 shared gene pathways of the KEGG database, the top 3 median ranked pathways were ECM-receptor interactions (median rank: UIC HNSCC 16, Breast 5.5, Melanoma 5, and MDACC HNSCC 8), protein digestion and absorption (median rank: UIC HNSCC 16, Breast 10.5, Melanoma 3, and MDACC HNSCC 23), and focal adhesion (median rank: UIC HNSCC 15.5, Breast 10.5, Melanoma 5.5, and MDACC HNSCC 23;  FIGS. 6B and 6C ). Therefore, in four different datasets encompassing HNSCCs, breast cancers, and melanomas, this LNM-specific classifier identified a Group 2-like subtype displaying similar biological subtypes and clinical outcomes. 
     Discussion: Here, these experiments identified 3 distinct molecular subtypes of LNMs that were associated with differences in clinical outcomes after surgery and post-operative radiotherapy. These subtypes, termed Group 1, Group 2, and Group 3, displayed an immune, an invasive, and a metabolic/proliferative phenotype, respectively. In contrast to Group 1 and Group 3 LNM subtypes, the Group 2 LNM subtype was associated with significantly worse locoregional control, relapse-free survival, and overall survival. These subtypes are likely specific to LNMs for several reasons. First, LNMs subtypes were not observed in the matched primary tumors using either unsupervised or supervised approaches. Second, a similar Group 2 subtype was also identified in breast, melanoma, and MDACC HNSCC LNMs datasets and displayed similar gene expression patterns as well as increased risk for recurrence and death. Similar to the absence of these LNMs subtypes in primary HNSCCs, this Group 2 subtype was not associated with recurrence and survival differences when classifying non-LNMs sites. Even though these LNMs subtypes were identified using a single institution retrospective dataset encompassing 34 patients, similar observations were validated in existing prospective and retrospective datasets totaling 373 patients across 3 different cancer types. Thus, described herein is a novel molecular classification of LNMs metastasis, which has both biologic and prognostic significance in HNSCCs and likely extends to LNMs in other cancers. 
     Previous attempts to biologically classify HNSCCs have mostly relied upon supervised analysis incorporating known patient outcomes in order to identify mutations and/or differentially expressed genes that correlated with worse survival (25, 28, 31-33). By contrast, fewer studies have used unbiased strategies to classify HNSCCs into distinct biological subtypes that would predict different biological outcomes (26, 34, 35). In either case, previous reports have almost always focused on the primary tumor which likely masks small subpopulations of aggressive variants due tumor heterogeneity (25, 26, 34-39). To this end, LNMs subtypes identified here were not detected in matched primary tumors using unbiased integrative clustering, supervised clustering of DEmRNAs, or a 73-gene LNM-specific classifier. These findings are consistent with a few reports that demonstrate lymph node and/or distant metastases are molecularly distinct from the primary tumor (40). Unlike these results describing LNM-specific subtypes, most previous studies of LNMs in HNSCCs and other cancers demonstrated mutational and transcriptional profiles that were most similar to the matched primary tumors (16, 17, 29, 41-43). However, these studies were not designed to identify LNM-specific molecular subtypes because analyses combined both the primary tumors and LNMs from multiple patients. By comparing LNMs to primary tumors, the variance between patients likely confounded the identification of differences between primary tumors and LNMs and, therefore, was not optimized to identify LNM-specific differences. Furthermore, compared to previous studies, the experiments described here used 5 to 7-fold more LNMs samples that provided greater power to identify distinct LNM subtypes. Therefore, classifying the molecular differences present in LNMs provides novel biological and prognostic information to lead to more effective and/or targeted treatments of cancer. 
     The present LNM-specific molecular subtypes represent an invasive subtype (Group 2), an inflammatory subtype (Group 1), and a metabolic/proliferative subtype (Group 3). Others have described 3 to 6 subtypes in primary HNSCCs (35, 38, 44, 45). Pathways enriched in the Group 2 LNM subtype were similar to pathways enriched in a basal hypoxia or angiogenesis subtype in primary HNSCCs (34, 35, 38, 44, 45). Similarly, pathways enriched in the Group 2 or Group 3 LNMs subtype were similar to pathways enriched in the inflamed/mesenchymal subtype (35, 38, 44, 45) or classical-atypical subtype (34, 35, 44, 45) in primary HNSCCs, respectively. However, in contrast to the observations presented herein, differences in molecular subtypes of primary HNSCCs were not often associated with differences in clinical outcomes. Although Chung et al. did find that an intrinsic classification system in addition to other clinicopathological features were associated with worse recurrence free survival (34, 37), the LNM-subtype was observed to be the sole factor associated with cancer recurrence. Keck et al. (35) observed survival differences between HNSCC subtypes, but these differences were mainly due to differences in survival between HPV-positive and HPV-negative HNSCC subtypes. By contrast, this study identified subtypes of HPV-negative HNSCCs that were associated with significant survival differences. One explanation for these differences between the present findings and others is that LNMs represent the biological selection of aggressive variants compared to a more genetically heterogeneous primary tumor. 
     LNMs likely reflect biological selection of clinically relevant subpopulations as well as display LN-specific gene expression patterns. The biological selection of LNMs was supported by the observation that existing prognostic classifiers in HNSCCs (25-28) identified patients at increased risk of locoregional failure and relapse-free survival primarily when applied to the transcriptional profiles of LNMs but not to the transcriptional profiles of primary tumors. 
     However, these existing classifiers only predicted the Group 2 LNM subtype with 60-80% accuracy. By contrast, a novel 73 gene classifier identified Group 2-like subtypes in multiple cancer types only when applied to the gene expression patterns of LNMs but not when applied to non-lymph node sites indicating that LNMs also reflect LN-specific changes in the gene expression patterns of metastases. Similarly, in liver metastases, a selective gene signature was associated with adverse outcomes in patients with a luminal A breast cancer subtype (46). Thus, reported herein is a novel LNM-specific classifier that predicts outcomes using both retrospective and prospective data sets encompassing multiple cancer types. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Overall patient characteristics. 
               
            
           
           
               
               
               
            
               
                   
                   
                 All patients, No. of  
               
               
                   
                   
                 patients (%) (n = 34) 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Follow up, median months 
                 25.8 
               
               
                   
                 (interquartile ratio) 
                  (7.3-59.8) 
               
               
                   
                 Median age 
                 59.9 
               
               
                   
                 (interquartile ratio) 
                 (47.7-64.9) 
               
               
                   
                 Gender 
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Male 
                 23 
                 (69.7%) 
               
               
                   
                 Female 
                 10 
                 (30.3%) 
               
               
                   
                 KPS 
                   
                   
               
               
                   
                 ≥70 
                 30 
                 (93.8%) 
               
               
                   
                 &lt;70 
                 2 
                 (6.3%) 
               
               
                   
                 Cormorbidity group 
                   
                   
               
               
                   
                 Medium 
                 25 
                 (75.8%) 
               
               
                   
                 High-very high 
                 8 
                 (24.2%) 
               
               
                   
                 Ethnicity 
                   
                   
               
               
                   
                 African American 
                 11 
                 (42.3%) 
               
               
                   
                 Caucasian 
                 15 
                 (57.7%) 
               
               
                   
                 Clinical T-classification 
                   
                   
               
               
                   
                 T1-2 
                 10 
                 (30.0%) 
               
               
                   
                 T3-4 
                 23 
                 (69.7%) 
               
               
                   
                 Clinical N-classification 
                   
                   
               
               
                   
                 N0-1 
                 17 
                 (51.5%) 
               
               
                   
                 N2-3 
                 16 
                 (48.5%) 
               
               
                   
                 Primary 
                   
                   
               
               
                   
                 Oral cavity 
                 25 
                 (75.8%) 
               
               
                   
                 Oropharynx 
                 1 
                 (3.0%) 
               
               
                   
                 Larynx 
                 4 
                 (12.1%) 
               
               
                   
                 Hypopharynx 
                 1 
                 (3.0%) 
               
               
                   
                 Other 
                 2 
                 (6.1%) 
               
               
                   
                 Alcohol use 
                   
                   
               
               
                   
                 Yes 
                 13 
                 (65.0%) 
               
               
                   
                 No 
                 7 
                 (35.0%) 
               
               
                   
                 Smoking use 
                   
                   
               
               
                   
                 Yes 
                 21 
                 (63.6%) 
               
               
                   
                 No 
                 7 
                 (36.4%) 
               
               
                   
                 Pathologic T-classification 
                   
                   
               
               
                   
                 pT1-2 
                 11 
                 (65.6%) 
               
               
                   
                 pT3-4 
                 21 
                 (34.4%) 
               
               
                   
                 Pathologic N-classification 
                   
                   
               
               
                   
                 pN1 
                 6 
                 (18.2%) 
               
               
                   
                 pN2-3 
                 27 
                 (81.8%) 
               
               
                   
                 Margin status 
                   
                   
               
               
                   
                 Positive 
                 12 
                 (38.7%) 
               
               
                   
                 ≤5 mm 
                 11 
                 (34.5%) 
               
               
                   
                 Negative 
                 8 
                 (25.8%) 
               
               
                   
                 Perineural invasion 
                   
                   
               
               
                   
                 Yes 
                 12 
                 (36.4%) 
               
               
                   
                 No 
                 21 
                 (63.6%) 
               
               
                   
                 Lymphovascular space invasion 
                   
                   
               
               
                   
                 Yes 
                 11 
                 (33.3%) 
               
               
                   
                 No 
                 22 
                 (66.7%) 
               
               
                   
                 Extracapsular extension 
                   
                   
               
               
                   
                 Yes 
                 17 
                 (51.5%) 
               
               
                   
                 No 
                 16 
                 (48.5%) 
               
            
           
           
               
               
               
            
               
                   
                 Median number of positive LN 
                 3 
               
               
                   
                 (interquartile ratio) 
                 (2-5) 
               
               
                   
                 Median number of LN dissected 
                 28 
               
               
                   
                 (interquartile ratio) 
                 (22-38) 
               
               
                   
                 Median radiation dose to  
                 6600 
               
               
                   
                 post-op bed 
                   
               
               
                   
                 (interquartile ratio) 
                 (6300-6600) 
               
               
                   
                 Treatment package time, days 
                 96 
               
               
                   
                 (interquartile ratio) 
                  (86-106) 
               
               
                   
                 Post operative chemoradiation 
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Yes 
                 26 
                 (78.8%) 
               
               
                   
                 No 
                 7 
                 (21.2%) 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Patient characteristics by lymph node molecular classification. 
               
            
           
           
               
               
            
               
                   
                 All patients, No. of patients (%) 
               
            
           
           
               
               
               
               
               
            
               
                   
                 LN Group 1 
                 LN Group 2 
                 LN Group 3 
                 P 
               
               
                   
                 (n = 15) 
                 (n = 10) 
                 (n = 8) 
                 value 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Median age 
                 52.3 
                 61.7 
                 61.7 
                 .51 
               
               
                 (interquartile ratio) 
                 (46.9-67.6) 
                 (51.3-65.3) 
                 (52.6-64.8) 
                   
               
               
                 Gender 
                   
                   
                   
                 .87 
               
               
                 Male 
                 11 (73.3%) 
                 7 (70.0%) 
                 5 (62.5%) 
                   
               
               
                 Female 
                  4 (26.7%) 
                 3 (30.0%) 
                 3 (37.5%) 
                   
               
               
                 KPS 
                   
                   
                   
                 .57 
               
               
                 ≥70 
                 14 (93.3%) 
                 9 (90.0%) 
                  7 (100.0%) 
                   
               
               
                 &lt;70 
                 1 (6.7%) 
                 1 (10.0%) 
                 0 (0.0%) 
                   
               
               
                 Cormorbidity  
                   
                   
                   
                 .85 
               
               
                 group 
                   
                   
                   
                   
               
               
                 Medium 
                 12 (80.0%) 
                 7 (70.0%) 
                 6 (75.0%) 
                   
               
               
                 High-very high 
                  3 (20.0%) 
                 3 (30.0%) 
                 2 (25.0%) 
                   
               
               
                 Ethnicity 
                   
                   
                   
                 .82 
               
               
                 African American 
                  5 (58.3%) 
                 2 (33.3%) 
                 4 (50.0%) 
                   
               
               
                 Caucasian 
                  7 (41.7%) 
                 4 (66.7%) 
                 4 (50.0%) 
                   
               
               
                 Clinical T- 
                   
                   
                   
                 .67 
               
               
                 classification 
                   
                   
                   
                   
               
               
                 T1-2 
                  5 (33.3%) 
                 2 (20.0%) 
                 3 (37.5%) 
                   
               
               
                 T3-4 
                 10 (66.7%) 
                 8 (80.0%) 
                 5 (62.5%) 
                   
               
               
                 Clinical N- 
                   
                   
                   
                 .62 
               
               
                 classification 
                   
                   
                   
                   
               
               
                 N0-1 
                  6 (53.3%) 
                 6 (60.0%) 
                 3 (37.5%) 
                   
               
               
                 N2-3 
                  7 (46.7%) 
                 4 (40.0%) 
                 5 (62.5%) 
                   
               
               
                 Primary 
                   
                   
                   
                 .08 
               
               
                 Oral cavity 
                 12 (80.0%) 
                  10 (100.0%) 
                  3 (37.5%) 
                   
               
               
                 Oropharynx 
                 1 (6.7%) 
                 0 (0.0%) 
                 0 (0.0%) 
                   
               
               
                 Larynx 
                 1 (6.7%) 
                 0 (0.0%) 
                  3 (37.5%) 
                   
               
               
                 Hypopharynx 
                 0 (0.0%) 
                 0 (0.0%) 
                 1 (6.7%) 
                   
               
               
                 Other 
                 1 (6.7%) 
                 0 (0.0%) 
                 1 (6.7%) 
                   
               
               
                 Alcohol use 
                   
                   
                   
                 .98 
               
               
                 Yes 
                  5 (62.5%) 
                 4 (66.7%) 
                 4 (66.7%) 
                   
               
               
                 No 
                  3 (37.5%) 
                 2 (33.3%) 
                 2 (33.3%) 
                   
               
               
                 Smoking use 
                   
                   
                   
                 .10 
               
               
                 Yes 
                 10 (66.7%) 
                 4 (40.0%) 
                 7 (87.5%) 
                   
               
               
                 No 
                  5 (33.3%) 
                 6 (60.0%) 
                 1 (12.5%) 
                   
               
               
                 Pathologic T- 
                   
                   
                   
                 .11 
               
               
                 classification 
                   
                   
                   
                   
               
               
                 pT1-2 
                  6 (42.9%) 
                 1 (10.0%) 
                 4 (50.0%) 
                   
               
               
                 pT3-4 
                  8 (57.1%) 
                 9 (90.0%) 
                 4 (50.0%) 
                   
               
               
                 Pathologic  
                   
                   
                   
                 .53 
               
               
                 N-classification 
                   
                   
                   
                   
               
               
                 pNx-1 
                  2 (13.3%) 
                 3 (30.0%) 
                 1 (12.5%) 
                   
               
               
                 pN2-3 
                 13 (86.7%) 
                 7 (70.0%) 
                 7 (87.5%) 
                   
               
               
                 Margin status 
                   
                   
                   
                 .10 
               
               
                 Positive 
                  2 (14.3%) 
                 6 (60.0%) 
                 4 (57.1%) 
                   
               
               
                 ≤5 mm 
                  6 (42.9%) 
                 3 (30.0%) 
                 2 (28.6%) 
                   
               
               
                 Negative 
                  6 (42.9%) 
                 1 (10.0%) 
                 1 (14.3%) 
                   
               
               
                 Perineural invasion 
                   
                   
                   
                 .18 
               
               
                 Yes 
                  4 (26.7%) 
                 6 (60.0%) 
                 2 (25.0%) 
                   
               
               
                 No 
                 11 (73.3%) 
                 4 (40.0%) 
                 6 (75.0%) 
                   
               
               
                 Lymphovascular  
                   
                   
                   
                 .02 
               
               
                 space invasion 
                   
                   
                   
                   
               
               
                 Yes 
                  3 (20.0%) 
                 2 (20.0%) 
                 6 (75.0%) 
                   
               
               
                 No 
                 12 (80.0%) 
                 8 (80.0%) 
                 2 (25.0%) 
                   
               
               
                 Extracapsular  
                   
                   
                   
                 .80 
               
               
                 extension 
                   
                   
                   
                   
               
               
                 Yes 
                 7 (46.7%) 
                 6 (60.0%) 
                 4 (50.0%) 
                   
               
               
                 No 
                 8 (53.3%) 
                 4 (40.0%) 
                 4 (50.0%) 
                   
               
               
                 Median number  
                 3 
                 4.5 
                 2.5 
                 .56 
               
               
                 of positive LN 
                   
                   
                   
                   
               
               
                 (interquartile ratio) 
                   (2-3.5) 
                   (1-9.5) 
                 (1.25-4.75) 
                   
               
               
                 Median number  
                 28.5 
                 23.5 
                 42 
                 .03 
               
               
                 of LN dissected 
                   
                   
                   
                   
               
               
                 (interquartile ratio) 
                   (24-35.3) 
                 (17-32) 
                 (29.5-62)   
                   
               
               
                 Median radiation  
                 6600 
                 6600 
                 6200 
                 .25 
               
               
                 dose to post-op bed 
                 (6300-6600) 
                 (6300-6825) 
                 (5985-6600) 
                   
               
               
                 (interquartile ratio) 
                   
                   
                   
                   
               
               
                 Treatment package  
                 91 
                 97 
                 96 
                 .64 
               
               
                 time, days 
                   
                   
                   
                   
               
               
                 (interquartile ratio) 
                  (84.5-101.5) 
                 (82.5-110)  
                 (87.5-125)  
                   
               
               
                 Post operative  
                   
                   
                   
                 .57 
               
               
                 chemoradiation 
                   
                   
                   
                   
               
               
                 Yes 
                 13 (86.7%) 
                 7 (70.0%) 
                 6 (75.0%) 
                   
               
               
                 No 
                  2 (13.3%) 
                 3 (30.0%) 
                 2 (25.0%) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Univariate and multivariate analysis for locoregional control. 
               
            
           
           
               
               
               
            
               
                   
                 Univariate  
                 Multivariate  
               
               
                   
                 analysis for survival 
                 analysis for survival 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 P  
                   
                 P  
               
               
                   
                 Hazard ratio 
                 value 
                 Hazard ratio 
                 value 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 LN grouping 
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                 LN Group 1 
                 Reference 
                   
                 Reference 
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 LN Group 2 
                 12.91 
                 (2.52-103.23) 
                  .002 
                 10.00 (1.40-108.40) 
                 .02 
               
               
                 LN Group 3 
                 2.11 
                 (0.35-16.25) 
                 .40 
                 2.04 (0.27-17.82) 
                 .48 
               
               
                 LN grouping 
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                 LN Group 2 
                 Reference 
                   
                 Reference 
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 LN Group 1 
                 0.08 
                 (0.009-0.40) 
                 .002 
                 0.10 (0.01-0.71) 
                 .02 
               
               
                 LN Group 3 
                 0.16 
                 (0.0-0.79) 
                 .02 
                 0.20 (0.03-0.99) 
                 .04 
               
               
                 Primary site 
                   
                   
                   
                 N.D. 
                 N.D. 
               
            
           
           
               
               
               
               
               
            
               
                 Oral cavity 
                 Reference 
                   
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Oropharynx 
                 0.86 
                 (0.04-6.00) 
                 .90 
                   
                   
               
               
                 Larynx 
                 1.82 
                 (0.27-7.58) 
                 .49 
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                 Hypopharynx 
                 1.75 × 10 −9  (0.0-9.82)     
                 .50 
                   
                   
               
               
                 Other 
                 1.76 × 10 −10  (0.0-2.58) 
                 .21 
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Smoking use 
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                 No 
                 Reference 
                   
                 N.D. 
                 N.D. 
               
            
           
           
               
               
               
               
               
               
            
               
                 Yes 
                 0.97 
                 (0.26-4.61) 
                 .97 
                   
                   
               
               
                 Pathologic T- 
                   
                   
                   
                 N.D. 
                 N.D. 
               
               
                 classification 
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                 pT1-2 
                 Reference 
                   
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 pT3-4 
                 1.70 
                 (0.45-8.03 
                 .44 
                   
                   
               
               
                 Lympho-  
                   
                   
                   
                 N.D. 
                 N.D. 
               
               
                 vascular 
                   
                   
                   
                   
                   
               
               
                 space  
                   
                   
                   
                   
                   
               
               
                 invasion 
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                 No 
                 Reference 
                   
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Yes 
                 0.50 
                 (0.13-2.05) 
                 .42 
                   
                   
               
               
                 Margin status 
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                 Negative 
                 Reference 
                   
                 Reference 
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 ≤5 mm 
                 2.19 
                 (0.27-44.92) 
                 .48 
                 2.71 (0.32-57.10) 
                 .37 
               
               
                 Positive 
                 5.58 
                 (0.95-105.81) 
                 .06 
                 2.71 (0.41-54.34) 
                 .33 
               
               
                 Extent of LN  
                   
                   
                   
                 N.D. 
                 N.D. 
               
               
                 dissection 
                   
                   
                   
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                 ≤28 LN 
                 Reference 
                   
                   
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 &gt;28 LN 
                 0.49 
                 (0.10-2.01) 
                 .31 
                   
                   
               
               
                   
               
               
                 Abbreviations: 
               
               
                 S + RT, surgery and post-operative radiotherapy; 
               
               
                 S + CRT, surgery and post operative chemoradiotherapy; 
               
               
                 pSG, pathological Stage Grouping; 
               
               
                 pT, pathological T classification; 
               
               
                 pN, pathological N classification; 
               
               
                 ≥2 LN, greater than or equal the 2 metastatic lymph nodes; 
               
               
                 LVSI, lymphovascular space invasion; 
               
               
                 LND, lymph node dissection. 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 DEmRNAs and DEmiRNAs in LNMs. 
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                 P.  
                 adj.  
                   
               
               
                 Comparison 
                 gene_id 
                 gene_symbol 
                 logFC 
                 AveExpr 
                 t 
                 Value 
                 P. Val 
                 B 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167077 
                 MEI1 
                 −0.610 
                 3.535 
                 −2.666 
                 0.011 
                 0.050 
                 −2.888 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000106278 
                 PTPRZ1 
                 0.646 
                 6.146 
                 2.668 
                 0.011 
                 0.050 
                 −3.055 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000131196 
                 NFATC1 
                 −0.781 
                 5.700 
                 −2.669 
                 0.011 
                 0.050 
                 −3.065 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000079337 
                 RAPGEF3 
                 0.661 
                 5.155 
                 2.671 
                 0.011 
                 0.050 
                 −2.901 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000148357 
                 HMCN2 
                 −1.069 
                 3.520 
                 −2.672 
                 0.011 
                 0.050 
                 −2.880 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162105 
                 SHANK2 
                 0.780 
                 4.827 
                 2.673 
                 0.011 
                 0.050 
                 −2.954 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197863 
                 ZNF790 
                 −0.661 
                 3.500 
                 −2.677 
                 0.011 
                 0.049 
                 −2.897 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130592 
                 LSPI 
                 −0.831 
                 6.328 
                 −2.679 
                 0.011 
                 0.049 
                 −3.058 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167208 
                 SNX20 
                 −0.840 
                 4.543 
                 −2.692 
                 0.010 
                 0.048 
                 −2.898 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000092068 
                 SLC7A8 
                 0.788 
                 6.411 
                 2.693 
                 0.010 
                 0.048 
                 −2.950 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000149218 
                 ENDOD1 
                 0.615 
                 5.826 
                 2.694 
                 0.010 
                 0.048 
                 −2.969 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000121316 
                 PLBD1 
                 0.586 
                 4.153 
                 2.707 
                 0.010 
                 0.046 
                 −2.849 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143153 
                 ATPI B1 
                 0.671 
                 6.955 
                 2.714 
                 0.010 
                 0.046 
                 −2.940 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000136960 
                 ENPP2 
                 −0.691 
                 4.829 
                 −2.714 
                 0.010 
                 0.046 
                 −2.836 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000186684 
                 CYP27C1 
                 0.729 
                 3.973 
                 2.721 
                 0.009 
                 0.045 
                 −2.766 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167723 
                 TRPV3 
                 0.814 
                 4.786 
                 2.722 
                 0.009 
                 0.045 
                 −2.839 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000090776 
                 EFNB1 
                 0.886 
                 6.034 
                 2.724 
                 0.009 
                 0.045 
                 −2.895 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000088367 
                 EPB41L1 
                 0.762 
                 5.184 
                 2.726 
                 0.009 
                 0.045 
                 −2.863 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000214595 
                 EML6 
                 −0.641 
                 4.640 
                 −2.730 
                 0.009 
                 0.045 
                 −2.804 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000253159 
                 PCDHGA12 
                 0.617 
                 2.731 
                 2.731 
                 0.009 
                 0.045 
                 −2.709 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000066294 
                 CD84 
                 −0.659 
                 6.667 
                 −2.735 
                 0.009 
                 0.044 
                 −2.869 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000254995 
                 STX16- 
                 −0.685 
                 2.961 
                 −2.744 
                 0.009 
                 0.044 
                 −2.704 
               
               
                   
                   
                 NPEPL1 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000065320 
                 NTN1 
                 0.589 
                 4.083 
                 2.747 
                 0.009 
                 0.044 
                 −2.862 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000103942 
                 HOMER2 
                 0.755 
                 5.826 
                 2.748 
                 0.009 
                 0.043 
                 −2.767 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000166575 
                 TMEM135 
                 −0.610 
                 4.536 
                 −2.750 
                 0.009 
                 0.043 
                 −2.751 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000073910 
                 FRY 
                 −0.669 
                 5.194 
                 −2.754 
                 0.009 
                 0.043 
                 −2.815 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000170456 
                 DENND5B 
                 −0.756 
                 5.167 
                 −2.755 
                 0.009 
                 0.043 
                 −2.801 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000051128 
                 HOMER3 
                 0.869 
                 4.957 
                 2.759 
                 0.009 
                 0.043 
                 −2.730 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000203326 
                 ZNF525 
                 −0.964 
                 4.471 
                 −2.762 
                 0.009 
                 0.042 
                 −2.763 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167984 
                 NLRC3 
                 −1.125 
                 5.656 
                 −2.762 
                 0.009 
                 0.042 
                 −2.765 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000154099 
                 DNAAFI 
                 −1.023 
                 3.752 
                 −2.762 
                 0.009 
                 0.042 
                 −2.712 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163359 
                 COL6A3 
                 0.740 
                 10.354 
                 2.763 
                 0.009 
                 0.042 
                 −2.836 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000124225 
                 PMEPA1 
                 0.670 
                 6.794 
                 2.765 
                 0.008 
                 0.042 
                 −2.843 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000147394 
                 ZNF185 
                 0.905 
                 5.831 
                 2.766 
                 0.008 
                 0.042 
                 −2.734 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137841 
                 PLCB2 
                 −0.765 
                 5.407 
                 −2.767 
                 0.008 
                 0.042 
                 −2.727 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141013 
                 GAS8 
                 0.653 
                 4.114 
                 2.769 
                 0.008 
                 0.042 
                 −2.688 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164050 
                 PLXNB1 
                 0.611 
                 7.069 
                 2.770 
                 0.008 
                 0.042 
                 −2.851 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198853 
                 RUSC2 
                 0.722 
                 4.928 
                 2.773 
                 0.008 
                 0.042 
                 −2.705 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000189195 
                 BTBD8 
                 −0.593 
                 2.669 
                 −2.778 
                 0.008 
                 0.041 
                 −2.623 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000101901 
                 ALG13 
                 −0.602 
                 6.365 
                 −2.784 
                 0.008 
                 0.041 
                 −2.746 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134369 
                 NAV1 
                 0.673 
                 7.976 
                 2.788 
                 0.008 
                 0.041 
                 −2.815 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134333 
                 LDHA 
                 0.643 
                 9.041 
                 2.791 
                 0.008 
                 0.040 
                 −2.804 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000184058 
                 TBX1 
                 0.646 
                 3.675 
                 2.793 
                 0.008 
                 0.040 
                 −2.622 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138311 
                 ZNF365 
                 0.863 
                 2.997 
                 2.793 
                 0.008 
                 0.040 
                 −2.584 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000126709 
                 IFI6 
                 1.063 
                 6.181 
                 2.800 
                 0.008 
                 0.040 
                 −2.746 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196923 
                 PDLIM7 
                 0.685 
                 6.118 
                 2.801 
                 0.008 
                 0.040 
                 −2.708 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143369 
                 ECM1 
                 1.075 
                 4.616 
                 2.801 
                 0.008 
                 0.040 
                 −2.601 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000093072 
                 CECR1 
                 −0.626 
                 6.003 
                 −2.802 
                 0.008 
                 0.040 
                 −2.728 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137070 
                 IL11RA 
                 −0.611 
                 4.816 
                 −2.802 
                 0.008 
                 0.040 
                 −2.641 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000070404 
                 FSTL3 
                 0.839 
                 5.126 
                 2.802 
                 0.008 
                 0.040 
                 −2.630 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000073792 
                 IGF2BP2 
                 1.148 
                 6.234 
                 2.803 
                 0.008 
                 0.040 
                 −2.761 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000030419 
                 IKZF2 
                 −0.618 
                 6.151 
                 −2.809 
                 0.008 
                 0.039 
                 −2.749 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000071073 
                 MGAT4A 
                 −0.592 
                 6.301 
                 −2.815 
                 0.007 
                 0.039 
                 −2.690 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000101384 
                 JAG1 
                 0.760 
                 8.293 
                 2.821 
                 0.007 
                 0.038 
                 −2.728 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000169908 
                 TM4SF1 
                 0.759 
                 6.782 
                 2.823 
                 0.007 
                 0.038 
                 −2.713 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000160703 
                 NLRX1 
                 0.690 
                 4.334 
                 2.828 
                 0.007 
                 0.038 
                 −2.559 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000101213 
                 PTK6 
                 0.611 
                 4.586 
                 2.831 
                 0.007 
                 0.038 
                 −2.549 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164687 
                 FABP5 
                 1.328 
                 7.402 
                 2.833 
                 0.007 
                 0.038 
                 −2.581 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143297 
                 FCRL5 
                 −0.995 
                 6.225 
                 −2.839 
                 0.007 
                 0.037 
                 −2.662 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116147 
                 TNR 
                 −0.956 
                 2.582 
                 −2.839 
                 0.007 
                 0.037 
                 −2.479 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000090104 
                 RGS1 
                 −0.636 
                 7.501 
                 −2.840 
                 0.007 
                 0.037 
                 −2.682 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000204262 
                 COL5A2 
                 1.054 
                 8.145 
                 2.841 
                 0.007 
                 0.037 
                 −2.686 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000179583 
                 CIITA 
                 −0.709 
                 7.843 
                 −2.845 
                 0.007 
                 0.037 
                 −2.678 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000159399 
                 HK2 
                 0.944 
                 6.709 
                 2.845 
                 0.007 
                 0.037 
                 −2.633 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167123 
                 CERCAM 
                 0.777 
                 5.523 
                 2.846 
                 0.007 
                 0.037 
                 −2.601 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000117399 
                 CDC20 
                 0.680 
                 4.779 
                 2.850 
                 0.007 
                 0.037 
                 −2.546 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000127152 
                 BCL11B 
                 −0.619 
                 6.280 
                 −2.853 
                 0.007 
                 0.036 
                 −2.619 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000182752 
                 PAPPA 
                 1.027 
                 5.882 
                 2.856 
                 0.007 
                 0.036 
                 −2.525 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137877 
                 SPTBN5 
                 0.621 
                 4.638 
                 2.858 
                 0.007 
                 0.036 
                 −2.554 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000145632 
                 PLK2 
                 0.701 
                 6.110 
                 2.859 
                 0.007 
                 0.036 
                 −2.565 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000165995 
                 CACNB2 
                 −0.691 
                 3.134 
                 −2.859 
                 0.007 
                 0.036 
                 −2.442 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134057 
                 CCNB1 
                 0.655 
                 4.868 
                 2.860 
                 0.007 
                 0.036 
                 −2.529 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000133816 
                 MICAL2 
                 0.663 
                 7.377 
                 2.860 
                 0.007 
                 0.036 
                 −2.633 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142945 
                 KIF2C 
                 0.587 
                 4.573 
                 2.863 
                 0.007 
                 0.036 
                 −2.534 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000070371 
                 CLTCL1 
                 0.752 
                 4.324 
                 2.864 
                 0.007 
                 0.036 
                 −2.467 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143367 
                 TUFT1 
                 0.772 
                 5.377 
                 2.864 
                 0.007 
                 0.036 
                 −2.539 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000127084 
                 FGD3 
                 −0.950 
                 5.444 
                 −2.867 
                 0.006 
                 0.036 
                 −2.538 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163347 
                 CLDN1 
                 1.052 
                 6.832 
                 2.869 
                 0.006 
                 0.036 
                 −2.610 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000066697 
                 MSANTD3 
                 0.629 
                 4.659 
                 2.871 
                 0.006 
                 0.035 
                 −2.496 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137269 
                 LRRC1 
                 0.695 
                 5.133 
                 2.872 
                 0.006 
                 0.035 
                 −2.535 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000270149 
                 RP11- 
                 0.758 
                 4.617 
                 2.873 
                 0.006 
                 0.035 
                 −2.505 
               
               
                   
                   
                 544M22.13 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000148498 
                 PARD3 
                 0.687 
                 5.941 
                 2.873 
                 0.006 
                 0.035 
                 −2.438 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000010610 
                 CD4 
                 −0.611 
                 5.993 
                 −2.875 
                 0.006 
                 0.035 
                 −2.552 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000185567 
                 AHNAK2 
                 0.808 
                 8.866 
                 2.876 
                 0.006 
                 0.035 
                 −2.603 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000132855 
                 ANGPTL3 
                 0.642 
                 2.275 
                 2.879 
                 0.006 
                 0.035 
                 −2.402 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000145703 
                 IQGAP2 
                 −0.630 
                 5.472 
                 −2.882 
                 0.006 
                 0.035 
                 −2.474 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000184916 
                 JAG2 
                 0.779 
                 5.913 
                 2.884 
                 0.006 
                 0.035 
                 −2.507 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000101670 
                 LIPG 
                 0.665 
                 5.391 
                 2.896 
                 0.006 
                 0.034 
                 −2.483 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100311 
                 PDGFB 
                 0.666 
                 4.381 
                 2.901 
                 0.006 
                 0.034 
                 −2.426 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000185222 
                 TCEAL9 
                 0.741 
                 3.915 
                 2.901 
                 0.006 
                 0.034 
                 −2.383 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000151006 
                 PRSS53 
                 0.633 
                 3.673 
                 2.901 
                 0.006 
                 0.034 
                 −2.375 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000182957 
                 SPATA13 
                 −0.629 
                 5.991 
                 −2.906 
                 0.006 
                 0.033 
                 −2.510 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000119862 
                 LGALSL 
                 1.069 
                 5.054 
                 2.906 
                 0.006 
                 0.033 
                 −2.451 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000108821 
                 COL1A1 
                 1.297 
                 11.587 
                 2.908 
                 0.006 
                 0.033 
                 −2.478 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000154258 
                 ABCA9 
                 −0.691 
                 5.028 
                 −2.910 
                 0.006 
                 0.033 
                 −2.413 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000109861 
                 CTSC 
                 0.652 
                 8.068 
                 2.910 
                 0.006 
                 0.033 
                 −2.520 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000161958 
                 FGF11 
                 0.691 
                 4.460 
                 2.915 
                 0.006 
                 0.033 
                 −2.353 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198142 
                 SOWAHC 
                 0.665 
                 6.555 
                 2.916 
                 0.006 
                 0.033 
                 −2.466 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137642 
                 SORL1 
                 −0.644 
                 7.898 
                 −2.917 
                 0.006 
                 0.033 
                 −2.512 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000235162 
                 C12orf75 
                 0.634 
                 4.765 
                 2.917 
                 0.006 
                 0.033 
                 −2.390 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138434 
                 SSFA2 
                 0.608 
                 8.007 
                 2.918 
                 0.006 
                 0.033 
                 −2.510 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000072110 
                 ACTN1 
                 0.600 
                 8.384 
                 2.921 
                 0.006 
                 0.033 
                 −2.504 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000266074 
                 BAHCC1 
                 0.722 
                 5.591 
                 2.921 
                 0.006 
                 0.033 
                 −2.448 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000157514 
                 TSC22D3 
                 −0.679 
                 7.754 
                 −2.933 
                 0.005 
                 0.032 
                 −2.444 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138134 
                 STAMBPL1 
                 −0.641 
                 4.427 
                 −2.935 
                 0.005 
                 0.032 
                 −2.328 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164692 
                 COL1A2 
                 1.284 
                 10.783 
                 2.936 
                 0.005 
                 0.032 
                 −2.433 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000181092 
                 ADIPOQ 
                 −1.773 
                 3.075 
                 −2.936 
                 0.005 
                 0.032 
                 −2.263 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000091409 
                 ITGA6 
                 0.606 
                 8.993 
                 2.937 
                 0.005 
                 0.032 
                 −2.447 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000009950 
                 MLXIPL 
                 −0.739 
                 2.854 
                 −2.937 
                 0.005 
                 0.032 
                 −2.264 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000139351 
                 SYCP3 
                 −0.830 
                 3.252 
                 −2.940 
                 0.005 
                 0.032 
                 −2.280 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000120327 
                 PCDHB14 
                 0.654 
                 3.064 
                 2.941 
                 0.005 
                 0.031 
                 −2.279 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000102471 
                 NDFIP2 
                 0.611 
                 5.652 
                 2.945 
                 0.005 
                 0.031 
                 −2.383 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000091136 
                 LAMB1 
                 0.613 
                 8.028 
                 2.946 
                 0.005 
                 0.031 
                 −2.445 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196482 
                 ESRRG 
                 −0.737 
                 2.440 
                 −2.947 
                 0.005 
                 0.031 
                 −2.245 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000151208 
                 DLG5 
                 0.833 
                 7.342 
                 2.950 
                 0.005 
                 0.031 
                 −2.429 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000128641 
                 MYO1B 
                 0.755 
                 7.660 
                 2.952 
                 0.005 
                 0.031 
                 −2.412 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000110031 
                 LPXN 
                 −0.604 
                 4.750 
                 −2.951 
                 0.005 
                 0.031 
                 −2.275 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138964 
                 PARVG 
                 −0.820 
                 5.810 
                 −2.958 
                 0.005 
                 0.031 
                 −2.338 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000114270 
                 COL7A1 
                 0.809 
                 9.645 
                 2.959 
                 0.005 
                 0.031 
                 −2.387 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000119630 
                 PGF 
                 0.979 
                 4.384 
                 2.960 
                 0.005 
                 0.031 
                 −2.278 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142694 
                 EVA1B 
                 0.652 
                 3.218 
                 2.959 
                 0.005 
                 0.031 
                 −2.225 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000233436 
                 BTBD18 
                 −0.781 
                 3.385 
                 −2.961 
                 0.005 
                 0.031 
                 −2.244 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000103522 
                 IL21R 
                 −0.975 
                 5.182 
                 −2.967 
                 0.005 
                 0.030 
                 −2.292 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000090097 
                 PCBP4 
                 0.641 
                 3.865 
                 2.966 
                 0.005 
                 0.030 
                 −2.233 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198064 
                 RP11- 
                 −0.688 
                 4.845 
                 −2.968 
                 0.005 
                 0.030 
                 −2.272 
               
               
                   
                   
                 347C12.1 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000188171 
                 ZNF626 
                 −0.744 
                 3.786 
                 −2.970 
                 0.005 
                 0.030 
                 −2.206 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000170485 
                 NPAS2 
                 0.723 
                 5.305 
                 2.972 
                 0.005 
                 0.030 
                 −2.338 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000112378 
                 PERP 
                 0.925 
                 8.921 
                 2.973 
                 0.005 
                 0.030 
                 −2.371 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198736 
                 MSRB1 
                 0.652 
                 3.809 
                 2.974 
                 0.005 
                 0.030 
                 −2.176 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111732 
                 AICDA 
                 −1.086 
                 2.627 
                 −2.976 
                 0.005 
                 0.030 
                 −2.168 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000158315 
                 RHBDL2 
                 0.680 
                 3.228 
                 2.977 
                 0.005 
                 0.030 
                 −2.172 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000127554 
                 GFER 
                 0.805 
                 3.664 
                 2.978 
                 0.005 
                 0.030 
                 −2.193 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000175866 
                 BAIAP2 
                 0.640 
                 6.342 
                 2.980 
                 0.005 
                 0.030 
                 −2.346 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137648 
                 TMPRSS4 
                 1.489 
                 5.956 
                 2.982 
                 0.005 
                 0.029 
                 −2.341 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000169902 
                 TPST1 
                 0.598 
                 4.604 
                 2.983 
                 0.005 
                 0.029 
                 −2.233 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000171208 
                 NETO2 
                 0.667 
                 5.173 
                 2.986 
                 0.005 
                 0.029 
                 −2.198 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000213658 
                 LAT 
                 −0.667 
                 4.624 
                 −2.988 
                 0.005 
                 0.029 
                 −2.235 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000127824 
                 TUBA4A 
                 0.648 
                 6.168 
                 2.990 
                 0.005 
                 0.029 
                 −2.221 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000204147 
                 ASAH2B 
                 0.751 
                 3.583 
                 2.992 
                 0.005 
                 0.029 
                 −2.144 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000131620 
                 ANO1 
                 0.852 
                 6.926 
                 2.997 
                 0.005 
                 0.029 
                 −2.268 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000008853 
                 RHOBTB2 
                 −0.585 
                 5.166 
                 −2.998 
                 0.005 
                 0.029 
                 −2.231 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000136167 
                 LCP1 
                 −0.710 
                 7.731 
                 −3.006 
                 0.004 
                 0.028 
                 −2.260 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000268861 
                 CTD- 
                 −0.595 
                 3.268 
                 −3.005 
                 0.004 
                 0.028 
                 −2.108 
               
               
                   
                   
                 2207O23.3 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137563 
                 GGH 
                 0.656 
                 3.949 
                 3.006 
                 0.004 
                 0.028 
                 −2.134 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164142 
                 FAM160A1 
                 0.928 
                 4.893 
                 3.007 
                 0.004 
                 0.028 
                 −2.197 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000114529 
                 C3orf52 
                 0.806 
                 5.283 
                 3.010 
                 0.004 
                 0.028 
                 −2.206 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000039068 
                 CDH1 
                 0.835 
                 7.525 
                 3.012 
                 0.004 
                 0.028 
                 −2.283 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196329 
                 GIMAP5 
                 −0.849 
                 5.025 
                 −3.013 
                 0.004 
                 0.028 
                 −2.170 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000221926 
                 TRIM16 
                 0.671 
                 5.957 
                 3.016 
                 0.004 
                 0.028 
                 −2.198 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000175984 
                 DENND2C 
                 0.784 
                 5.625 
                 3.019 
                 0.004 
                 0.028 
                 −2.182 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000121903 
                 ZSCAN20 
                 0.720 
                 3.255 
                 3.020 
                 0.004 
                 0.028 
                 −2.083 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000123384 
                 LRP1 
                 0.709 
                 9.251 
                 3.026 
                 0.004 
                 0.027 
                 −2.240 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000179361 
                 ARID3B 
                 −0.648 
                 4.856 
                 −3.026 
                 0.004 
                 0.027 
                 −2.132 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000070729 
                 CNGB1 
                 1.487 
                 3.364 
                 3.029 
                 0.004 
                 0.027 
                 −2.039 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000110436 
                 SLC1A2 
                 −1.239 
                 3.190 
                 −3.030 
                 0.004 
                 0.027 
                 −2.047 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196616 
                 ADH1B 
                 −1.888 
                 3.867 
                 −3.031 
                 0.004 
                 0.027 
                 −2.049 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000110324 
                 IL10RA 
                 −0.755 
                 6.457 
                 −3.032 
                 0.004 
                 0.027 
                 −2.181 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000168477 
                 TNXB 
                 −0.972 
                 5.254 
                 −3.033 
                 0.004 
                 0.027 
                 −2.155 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000188906 
                 LRRK2 
                 −0.758 
                 5.285 
                 −3.033 
                 0.004 
                 0.027 
                 −2.122 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162433 
                 AK4 
                 0.848 
                 6.002 
                 3.037 
                 0.004 
                 0.027 
                 −2.169 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000159228 
                 CBR1 
                 0.770 
                 4.942 
                 3.037 
                 0.004 
                 0.027 
                 −2.111 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000149212 
                 SESN3 
                 −0.702 
                 7.940 
                 −3.040 
                 0.004 
                 0.027 
                 −2.215 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000147144 
                 CCDC120 
                 0.595 
                 4.898 
                 3.041 
                 0.004 
                 0.026 
                 −2.093 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000189159 
                 HN1 
                 0.669 
                 5.885 
                 3.045 
                 0.004 
                 0.026 
                 −2.126 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164181 
                 ELOVL7 
                 0.753 
                 4.131 
                 3.049 
                 0.004 
                 0.026 
                 −2.040 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000064687 
                 ABCA7 
                 −0.603 
                 5.763 
                 −3.057 
                 0.004 
                 0.026 
                 −2.138 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000152952 
                 PLOD2 
                 0.741 
                 6.608 
                 3.058 
                 0.004 
                 0.026 
                 −2.162 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000105639 
                 JAK3 
                 −0.670 
                 6.685 
                 −3.063 
                 0.004 
                 0.025 
                 −2.148 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162458 
                 FBLIM1 
                 0.773 
                 6.554 
                 3.066 
                 0.004 
                 0.025 
                 −2.128 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000183066 
                 WBP2NL 
                 −0.590 
                 2.797 
                 −3.066 
                 0.004 
                 0.025 
                 −1.957 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000009790 
                 TRAF3IP3 
                 −0.864 
                 5.648 
                 −3.069 
                 0.004 
                 0.025 
                 −2.064 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000176597 
                 B3GNT5 
                 0.682 
                 6.986 
                 3.070 
                 0.004 
                 0.025 
                 −2.117 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000176619 
                 LMNB2 
                 0.633 
                 6.892 
                 3.073 
                 0.004 
                 0.025 
                 −2.136 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000269190 
                 FBXO17 
                 0.620 
                 3.654 
                 3.072 
                 0.004 
                 0.025 
                 −1.996 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143126 
                 CELSR2 
                 0.847 
                 7.387 
                 3.078 
                 0.004 
                 0.025 
                 −2.117 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000124243 
                 BCAS4 
                 −0.681 
                 5.702 
                 −3.082 
                 0.004 
                 0.025 
                 −2.065 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000166145 
                 SPINT1 
                 0.949 
                 6.164 
                 3.082 
                 0.004 
                 0.025 
                 −2.081 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000090020 
                 SLC9A1 
                 0.609 
                 6.178 
                 3.085 
                 0.004 
                 0.025 
                 −2.066 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000088280 
                 ASAP3 
                 0.719 
                 4.772 
                 3.086 
                 0.004 
                 0.025 
                 −2.006 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000176014 
                 TUBB6 
                 0.620 
                 6.420 
                 3.086 
                 0.004 
                 0.025 
                 −2.060 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000139880 
                 CDH24 
                 0.658 
                 3.819 
                 3.089 
                 0.004 
                 0.024 
                 −1.959 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000185010 
                 F8 
                 −0.715 
                 3.242 
                 −3.094 
                 0.004 
                 0.024 
                 −1.896 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000128335 
                 APOL2 
                 0.695 
                 6.084 
                 3.096 
                 0.004 
                 0.024 
                 −2.032 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000147804 
                 SLC39A4 
                 0.624 
                 3.759 
                 3.095 
                 0.004 
                 0.024 
                 −1.944 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000166123 
                 GPT2 
                 0.588 
                 4.709 
                 3.097 
                 0.003 
                 0.024 
                 −1.945 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141338 
                 ABCA8 
                 −0.947 
                 3.217 
                 −3.100 
                 0.003 
                 0.024 
                 −1.882 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000113758 
                 DBN1 
                 0.686 
                 5.446 
                 3.100 
                 0.003 
                 0.024 
                 −2.001 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142156 
                 COL6A1 
                 1.008 
                 8.728 
                 3.106 
                 0.003 
                 0.024 
                 −2.042 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000139629 
                 GALNT6 
                 0.893 
                 5.858 
                 3.109 
                 0.003 
                 0.024 
                 −1.985 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000060656 
                 PTPRU 
                 0.874 
                 4.935 
                 3.116 
                 0.003 
                 0.023 
                 −1.949 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100994 
                 PYGB 
                 0.650 
                 7.445 
                 3.121 
                 0.003 
                 0.023 
                 −2.010 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000136002 
                 ARHGEF4 
                 0.979 
                 6.602 
                 3.125 
                 0.003 
                 0.023 
                 −1.998 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000099377 
                 HSD3B7 
                 0.624 
                 4.049 
                 3.126 
                 0.003 
                 0.023 
                 −1.830 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111679 
                 PTPN6 
                 −0.626 
                 5.799 
                 −3.128 
                 0.003 
                 0.023 
                 −1.929 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000240184 
                 PCDHGC3 
                 0.785 
                 5.779 
                 3.128 
                 0.003 
                 0.023 
                 −1.922 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000065361 
                 ERBB3 
                 1.017 
                 5.836 
                 3.129 
                 0.003 
                 0.023 
                 −1.915 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000184060 
                 ADAP2 
                 0.661 
                 4.480 
                 3.133 
                 0.003 
                 0.023 
                 −1.829 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000066468 
                 FGFR2 
                 0.680 
                 5.366 
                 3.140 
                 0.003 
                 0.022 
                 −1.916 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000181690 
                 PLAG1 
                 −0.721 
                 4.011 
                 −3.141 
                 0.003 
                 0.022 
                 −1.872 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000161647 
                 MPP3 
                 0.722 
                 3.961 
                 3.141 
                 0.003 
                 0.022 
                 −1.833 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000151014 
                 NOCT 
                 0.614 
                 4.710 
                 3.142 
                 0.003 
                 0.022 
                 −1.857 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000135119 
                 RNFT2 
                 −0.644 
                 4.283 
                 −3.146 
                 0.003 
                 0.022 
                 −1.829 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000087077 
                 TRIP6 
                 0.591 
                 5.740 
                 3.148 
                 0.003 
                 0.022 
                 −1.901 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000136286 
                 MYO1G 
                 −0.604 
                 5.435 
                 −3.149 
                 0.003 
                 0.022 
                 −1.853 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000113532 
                 ST8SIA4 
                 −0.644 
                 5.509 
                 −3.156 
                 0.003 
                 0.022 
                 −1.832 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000107611 
                 CUBN 
                 −0.899 
                 3.953 
                 −3.t57 
                 0.003 
                 0.022 
                 −1.788 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000107742 
                 SPOCK2 
                 −0.967 
                 6.174 
                 −3.157 
                 0.003 
                 0.022 
                 −1.876 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000074370 
                 ATP2A3 
                 −1.120 
                 6.273 
                 −3.158 
                 0.003 
                 0.022 
                 −1.887 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163701 
                 IL17RE 
                 0.856 
                 3.776 
                 3.161 
                 0.003 
                 0.022 
                 −1.739 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000110328 
                 GALNT18 
                 0.684 
                 4.421 
                 3.161 
                 0.003 
                 0.022 
                 −1.802 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000105514 
                 RAB3D 
                 0.738 
                 5.993 
                 3.163 
                 0.003 
                 0.021 
                 −1.851 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000086570 
                 FAT2 
                 0.992 
                 8.556 
                 3.169 
                 0.003 
                 0.021 
                 −1.892 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000158747 
                 NBL1 
                 0.660 
                 6.766 
                 3.169 
                 0.003 
                 0.021 
                 −1.855 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000172379 
                 ARNT2 
                 −1.060 
                 3.551 
                 −3.174 
                 0.003 
                 0.021 
                 −1.773 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000205269 
                 TMEM170B 
                 −0.657 
                 3.849 
                 −3.176 
                 0.003 
                 0.021 
                 −1.762 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000154102 
                 C16orf74 
                 0.719 
                 3.996 
                 3.176 
                 0.003 
                 0.021 
                 −1.712 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000115137 
                 DNAJC27 
                 −0.631 
                 3.926 
                 −3.178 
                 0.003 
                 0.021 
                 −1.713 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000166444 
                 ST5 
                 0.680 
                 6.753 
                 3.185 
                 0.003 
                 0.021 
                 −1.833 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000148200 
                 NR6A1 
                 0.825 
                 3.929 
                 3.187 
                 0.003 
                 0.020 
                 −1.711 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000181896 
                 ZNF101 
                 −0.829 
                 6.042 
                 −3.188 
                 0.003 
                 0.020 
                 −1.801 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000165359 
                 INTS6L 
                 −0.859 
                 5.518 
                 −3.191 
                 0.003 
                 0.020 
                 −1.750 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000056972 
                 TRAF3IP2 
                 0.619 
                 5.913 
                 3.191 
                 0.003 
                 0.020 
                 −1.785 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000072682 
                 P4HA2 
                 0.910 
                 5.644 
                 3.194 
                 0.003 
                 0.020 
                 −1.700 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198053 
                 SIRPA 
                 0.594 
                 6.472 
                 3.196 
                 0.003 
                 0.020 
                 −1.754 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000168542 
                 COL3A1 
                 1.223 
                 11.045 
                 3.200 
                 0.003 
                 0.020 
                 −1.786 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000158517 
                 NCF1 
                 −0.854 
                 4.067 
                 −3.201 
                 0.003 
                 0.020 
                 −1.669 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000172403 
                 SYNPO2 
                 −1.116 
                 5.885 
                 −3.201 
                 0.003 
                 0.020 
                 −1.768 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100342 
                 APOL1 
                 1.056 
                 6.563 
                 3.202 
                 0.003 
                 0.020 
                 −1.780 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000131981 
                 LGALS3 
                 0.662 
                 6.015 
                 3.203 
                 0.003 
                 0.020 
                 −1.748 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000005379 
                 TSPOAP1 
                 −0.706 
                 4.770 
                 −3.203 
                 0.003 
                 0.020 
                 −1.728 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000088305 
                 DNMT3B 
                 0.721 
                 3.470 
                 3.202 
                 0.003 
                 0.020 
                 −1.642 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163702 
                 ID7RC 
                 0.722 
                 4.316 
                 3.205 
                 0.003 
                 0.020 
                 −1.645 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000148926 
                 ADM 
                 0.932 
                 5.508 
                 3.207 
                 0.003 
                 0.020 
                 −1.746 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000158163 
                 DZIP1L 
                 0.842 
                 4.371 
                 3.210 
                 0.003 
                 0.020 
                 −1.643 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000187961 
                 KLHL17 
                 0.611 
                 3.662 
                 3.214 
                 0.003 
                 0.020 
                 −1.614 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000075618 
                 FSCN1 
                 0.832 
                 7.964 
                 3.216 
                 0.003 
                 0.020 
                 −1.769 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000185432 
                 METTL7A 
                 −0.754 
                 5.754 
                 −3.220 
                 0.003 
                 0.019 
                 −1.725 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000168675 
                 LDLRAD4 
                 −0.632 
                 6.335 
                 −3.222 
                 0.002 
                 0.019 
                 −1.741 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141526 
                 SLC16A3 
                 0.633 
                 6.890 
                 3.223 
                 0.002 
                 0.019 
                 −1.751 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130844 
                 ZNF331 
                 −0.948 
                 5.844 
                 −3.224 
                 0.002 
                 0.019 
                 −1.690 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000005844 
                 ITGAL 
                 −0.959 
                 5.812 
                 −3.235 
                 0.002 
                 0.019 
                 −1.641 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142173 
                 COL6A2 
                 1.014 
                 8.760 
                 3.238 
                 0.002 
                 0.019 
                 −1.717 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130518 
                 KIAA1683 
                 −0.693 
                 4.289 
                 −3.239 
                 0.002 
                 0.019 
                 −1.609 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130755 
                 GMFG 
                 −0.901 
                 4.241 
                 −3.240 
                 0.002 
                 0.019 
                 −1.569 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000067836 
                 ROGDI 
                 0.613 
                 3.801 
                 3.238 
                 0.002 
                 0.019 
                 −1.549 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162777 
                 DENND2D 
                 −0.640 
                 5.905 
                 −3.242 
                 0.002 
                 0.019 
                 −1.658 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162511 
                 LAPTM5 
                 −0.652 
                 7.971 
                 −3.243 
                 0.002 
                 0.019 
                 −1.697 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000089820 
                 ARHGAP4 
                 −0.764 
                 6.017 
                 −3.244 
                 0.002 
                 0.019 
                 −1.646 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000214193 
                 SH3D21 
                 0.946 
                 5.055 
                 3.244 
                 0.002 
                 0.019 
                 −1.603 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000115163 
                 CENPA 
                 0.667 
                 3.216 
                 3.251 
                 0.002 
                 0.018 
                 −1.520 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000133574 
                 GIMAP4 
                 −0.862 
                 4.506 
                 −3.254 
                 0.002 
                 0.018 
                 −1.535 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000146242 
                 TPBG 
                 0.760 
                 5.573 
                 3.256 
                 0.002 
                 0.018 
                 −1.606 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000121858 
                 TNFSF10 
                 0.781 
                 6.802 
                 3.258 
                 0.002 
                 0.018 
                 −1.658 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000186081 
                 KRT5 
                 1.037 
                 10.894 
                 3.260 
                 0.002 
                 0.018 
                 −1.604 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143119 
                 CD53 
                 −0.822 
                 6.129 
                 −3.261 
                 0.002 
                 0.018 
                 −1.582 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000140564 
                 FURIN 
                 0.609 
                 7.092 
                 3.261 
                 0.002 
                 0.018 
                 −1.662 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130940 
                 CASZ1 
                 0.815 
                 6.027 
                 3.261 
                 0.002 
                 0.018 
                 −1.646 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000115687 
                 PASK 
                 −0.610 
                 6.105 
                 −3.264 
                 0.002 
                 0.018 
                 −1.641 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000168389 
                 MFSD2A 
                 1.066 
                 4.277 
                 3.266 
                 0.002 
                 0.018 
                 −1.498 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000133477 
                 FAM83F 
                 0.950 
                 6.681 
                 3.274 
                 0.002 
                 0.018 
                 −1.622 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167642 
                 SPINT2 
                 0.665 
                 6.935 
                 3.275 
                 0.002 
                 0.018 
                 −1.610 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000180884 
                 ZNF792 
                 −0.593 
                 3.505 
                 −3.285 
                 0.002 
                 0.017 
                 −1.433 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000122122 
                 SASH3 
                 −0.917 
                 4.957 
                 −3.288 
                 0.002 
                 0.017 
                 −1.477 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000121104 
                 FAM117A 
                 −0.596 
                 4.152 
                 −3.287 
                 0.002 
                 0.017 
                 −1.470 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141441 
                 GAREM1 
                 0.662 
                 4.653 
                 3.294 
                 0.002 
                 0.017 
                 −1.487 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196739 
                 COL27A1 
                 0.799 
                 7.510 
                 3.295 
                 0.002 
                 0.017 
                 −1.574 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000174564 
                 IL20RB 
                 1.068 
                 5.031 
                 3.297 
                 0.002 
                 0.017 
                 −1.471 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000005884 
                 ITGA3 
                 0.768 
                 8.088 
                 3.298 
                 0.002 
                 0.017 
                 −1.555 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000183963 
                 SMTN 
                 0.841 
                 6.410 
                 3.309 
                 0.002 
                 0.016 
                 −1.495 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163362 
                 C1orf106 
                 0.687 
                 6.096 
                 3.311 
                 0.002 
                 0.016 
                 −1.502 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000121579 
                 NAA50 
                 0.596 
                 7.985 
                 3.316 
                 0.002 
                 0.016 
                 −1.522 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000104341 
                 LAPTM4B 
                 0.631 
                 6.305 
                 3.316 
                 0.002 
                 0.016 
                 −1.462 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000122862 
                 SRGN 
                 −0.607 
                 6.383 
                 −3.319 
                 0.002 
                 0.016 
                 −1.437 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163472 
                 TMEM79 
                 1.075 
                 4.833 
                 3.320 
                 0.002 
                 0.016 
                 −1.370 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000069020 
                 MAST4 
                 0.704 
                 7.282 
                 3.323 
                 0.002 
                 0.016 
                 −1.474 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000074211 
                 PPP2R2C 
                 1.124 
                 5.856 
                 3.326 
                 0.002 
                 0.016 
                 −1.366 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000112576 
                 CCND3 
                 −0.761 
                 6.494 
                 −3.326 
                 0.002 
                 0.016 
                 −1.464 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000076555 
                 ACACB 
                 −0.827 
                 5.486 
                 −3.327 
                 0.002 
                 0.016 
                 −1.414 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000109079 
                 TNFAIP1 
                 0.688 
                 6.362 
                 3.327 
                 0.002 
                 0.016 
                 −1 459 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000178878 
                 APOLD1 
                 −0.736 
                 5.610 
                 −3.330 
                 0.002 
                 0.016 
                 −1.424 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196639 
                 HRH1 
                 0.963 
                 3.668 
                 3.331 
                 0.002 
                 0.016 
                 −1.329 
               
               
                 LNM Group 2 vs. Group f 
                 ENSG00000117215 
                 PLA2G2D 
                 −1.423 
                 3.360 
                 −3.336 
                 0.002 
                 0.016 
                 −1.331 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000153898 
                 MCOLN2 
                 −0.825 
                 4.281 
                 −3.337 
                 0.002 
                 0.016 
                 −1.330 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000069702 
                 TGFBR3 
                 −1.169 
                 5.192 
                 −3.339 
                 0.002 
                 0.016 
                 −1.423 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134769 
                 DTNA 
                 −0.841 
                 3.506 
                 −3.340 
                 0.002 
                 0.016 
                 −1.315 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141576 
                 RNF157 
                 −1.072 
                 3.811 
                 −3.342 
                 0.002 
                 0.016 
                 −1.309 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000176358 
                 TAC4 
                 −0.736 
                 2.555 
                 −3.342 
                 0.002 
                 0.016 
                 −1.289 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000075275 
                 CELSR1 
                 0.627 
                 7.814 
                 3.349 
                 0.002 
                 0.015 
                 −1.437 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000114166 
                 KAT2B 
                 −0.616 
                 5.467 
                 −3.352 
                 0.002 
                 0.015 
                 −1.327 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000115657 
                 ABCB6 
                 0.602 
                 4.620 
                 3.354 
                 0.002 
                 0.015 
                 −1.311 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000176170 
                 SPHK1 
                 0.970 
                 5.431 
                 3.358 
                 0.002 
                 0.015 
                 −1.325 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000041353 
                 RAB27B 
                 1.111 
                 4.986 
                 3.359 
                 0.002 
                 0.015 
                 −1.299 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000074964 
                 ARHGEF10L 
                 0.696 
                 5.531 
                 3.359 
                 0.002 
                 0.015 
                 −1.315 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116299 
                 KIAA1324 
                 −1.125 
                 4.048 
                 −3.360 
                 0.002 
                 0.015 
                 −1.262 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000213859 
                 KCTD11 
                 0.799 
                 5.282 
                 3.361 
                 0.002 
                 0.015 
                 −1.299 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167306 
                 MYO5B 
                 1.523 
                 5.841 
                 3.362 
                 0.002 
                 0.015 
                 −1.371 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000258555 
                 SPECC1L- 
                 −0.595 
                 2.914 
                 −3.363 
                 0.002 
                 0.015 
                 −1.234 
               
               
                   
                   
                 ADORA2A 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000115884 
                 SDC1 
                 0.956 
                 8.680 
                 3.368 
                 0.002 
                 0.015 
                 −1.382 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000171444 
                 MCC 
                 0.714 
                 7.023 
                 3.370 
                 0.002 
                 0.015 
                 −1.367 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000261739 
                 GOLGA8S 
                 −0.590 
                 2.168 
                 −3.370 
                 0.002 
                 0.015 
                 −1.200 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164070 
                 HSPA4L 
                 0.706 
                 5.893 
                 3.374 
                 0.002 
                 0.015 
                 −1.347 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198440 
                 ZNF583 
                 −0.745 
                 3.358 
                 −3.376 
                 0.002 
                 0.015 
                 −1.257 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000145555 
                 MYO10 
                 0.886 
                 7.441 
                 3.379 
                 0.002 
                 0.015 
                 −1.354 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000140030 
                 GPR65 
                 −0.658 
                 3.563 
                 −3.380 
                 0.002 
                 0.014 
                 −1.192 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000187764 
                 SEMA4D 
                 −0.788 
                 7.085 
                 −3.387 
                 0.002 
                 0.014 
                 −1.334 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000139116 
                 KIF21A 
                 0.755 
                 5.631 
                 3.387 
                 0.002 
                 0.014 
                 −1.301 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198168 
                 SVIP 
                 −0.765 
                 4.362 
                 −3.390 
                 0.002 
                 0.014 
                 −1.242 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000221955 
                 SLC12A8 
                 0.770 
                 4.876 
                 3.390 
                 0.002 
                 0.014 
                 −1.242 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000112655 
                 PTK7 
                 0.665 
                 7.125 
                 3.403 
                 0.001 
                 0.014 
                 −1.282 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000241399 
                 CD302 
                 −0.618 
                 4.228 
                 −3.402 
                 0.001 
                 0.014 
                 −1.180 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000236334 
                 PPIAL4G 
                 −0.588 
                 3.651 
                 −3.406 
                 0.001 
                 0.014 
                 −1.142 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000136541 
                 ERMN 
                 −0.768 
                 2.728 
                 −3.408 
                 0.001 
                 0.014 
                 −1.120 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000106211 
                 HSPB1 
                 0.825 
                 7.662 
                 3.410 
                 0.001 
                 0.014 
                 −1.271 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141524 
                 TMC6 
                 −0.585 
                 7.071 
                 −3.410 
                 0.001 
                 0.014 
                 −1.275 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162493 
                 PDPN 
                 1.082 
                 5.911 
                 3.413 
                 0.001 
                 0.014 
                 −1.222 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000240972 
                 MIF 
                 0.608 
                 5.654 
                 3.411 
                 0.001 
                 0.014 
                 −1.212 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000179163 
                 FUCA1 
                 −0.924 
                 4.552 
                 −3.414 
                 0.001 
                 0.014 
                 −1.151 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000176845 
                 METRNL 
                 0.693 
                 5.430 
                 3.414 
                 0.001 
                 0.014 
                 −1.195 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000105643 
                 ARRDC2 
                 −0.641 
                 5.605 
                 −3.415 
                 0.001 
                 0.014 
                 −1.207 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000180353 
                 HCLS1 
                 −0.729 
                 6.474 
                 −3.418 
                 0.001 
                 0.014 
                 −1.217 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000150637 
                 CD226 
                 −0.821 
                 5.227 
                 −3.422 
                 0.001 
                 0.013 
                 −1.153 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000172508 
                 CARNS1 
                 −0.880 
                 3.664 
                 −3.423 
                 0.001 
                 0.013 
                 −1.122 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000103042 
                 SLC38A7 
                 0.600 
                 5.188 
                 3.423 
                 0.001 
                 0.013 
                 −1.144 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000136104 
                 RNASEH2B 
                 −1.091 
                 6.086 
                 −3.426 
                 0.001 
                 0.013 
                 −1.164 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000184271 
                 POU6F1 
                 −0.932 
                 4.172 
                 −3.427 
                 0.001 
                 0.013 
                 −1.135 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000152642 
                 GPD1L 
                 −0.841 
                 4.336 
                 −3.430 
                 0.001 
                 0.013 
                 −1.081 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000124126 
                 PREX1 
                 −0.629 
                 6.531 
                 −3.437 
                 0.001 
                 0.013 
                 −1.164 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000172830 
                 SSH3 
                 0.605 
                 5.337 
                 3.438 
                 0.001 
                 0.013 
                 −1.102 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164674 
                 SYTL3 
                 −0.956 
                 4.341 
                 −3.441 
                 0.001 
                 0.013 
                 −1.069 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000147813 
                 NAPRT 
                 0.636 
                 5.317 
                 3.441 
                 0.001 
                 0.013 
                 −1.122 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000155307 
                 SAMSN1 
                 −0.779 
                 4.594 
                 −3.443 
                 0.001 
                 0.013 
                 −1.078 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000075826 
                 SEC31B 
                 −0.635 
                 5.082 
                 −3.442 
                 0.001 
                 0.013 
                 −1.102 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000103257 
                 SLC7A5 
                 0.744 
                 8.317 
                 3.448 
                 0.001 
                 0.013 
                 −1.175 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000102879 
                 CORO1A 
                 −1.061 
                 6.289 
                 −3.449 
                 0.001 
                 0.013 
                 −1.130 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198324 
                 FAM109A 
                 0.863 
                 3.686 
                 3.451 
                 0.001 
                 0.013 
                 −1.019 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000160360 
                 GPSM1 
                 0.640 
                 4.598 
                 3.453 
                 0.001 
                 0.013 
                 −1.083 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000152127 
                 MGAT5 
                 −0.593 
                 7.209 
                 −3.456 
                 0.001 
                 0.013 
                 −1.152 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000240038 
                 AMY2B 
                 −0.832 
                 4.752 
                 −3.458 
                 0.001 
                 0.013 
                 −1.040 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000135069 
                 PSAT1 
                 0.665 
                 4.241 
                 3.457 
                 0.001 
                 0.013 
                 −1.072 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000145246 
                 ATP10D 
                 0.604 
                 6.334 
                 3.459 
                 0.001 
                 0.013 
                 −1.078 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000243364 
                 EFNA4 
                 0.678 
                 2.767 
                 3.458 
                 0.001 
                 0.013 
                 −0.986 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143545 
                 RAB13 
                 0.587 
                 5.188 
                 3.461 
                 0.001 
                 0.013 
                 −1.057 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000101447 
                 FAM83D 
                 0.678 
                 4.293 
                 3.468 
                 0.001 
                 0.012 
                 −1.041 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000076770 
                 MBNL3 
                 −0.601 
                 6.216 
                 −3.469 
                 0.001 
                 0.012 
                 −1.076 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000074800 
                 ENO1 
                 0.611 
                 9.193 
                 3.470 
                 0.001 
                 0.012 
                 −1.106 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000127955 
                 GNAI1 
                 0.868 
                 4.967 
                 3.477 
                 0.001 
                 0.012 
                 −1.000 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138380 
                 CARF 
                 −0.626 
                 4.647 
                 −3.476 
                 0.001 
                 0.012 
                 −0.983 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000169991 
                 IFFO2 
                 1.009 
                 6.823 
                 3.479 
                 0.001 
                 0.012 
                 −1.086 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134668 
                 SPOCD1 
                 1.268 
                 3.729 
                 3.482 
                 0.001 
                 0.012 
                 −0.941 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000132481 
                 TRIM47 
                 0.615 
                 4.978 
                 3.490 
                 0.001 
                 0.012 
                 −0.962 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000147650 
                 LRP12 
                 0.636 
                 5.335 
                 3.491 
                 0.001 
                 0.012 
                 −1.009 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000188483 
                 IER5L 
                 0.704 
                 3.806 
                 3.493 
                 0.001 
                 0.012 
                 −0.938 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000185905 
                 C16orf54 
                 −0.719 
                 4.104 
                 −3.500 
                 0.001 
                 0.012 
                 −0.910 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197077 
                 KIAA1671 
                 0.614 
                 7.340 
                 3.502 
                 0.001 
                 0.012 
                 −1.028 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111728 
                 ST8SIA1 
                 −0.780 
                 4.947 
                 −3.504 
                 0.001 
                 0.012 
                 −0.962 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000171729 
                 TMEM51 
                 0.710 
                 3.740 
                 3.510 
                 0.001 
                 0.012 
                 −0.881 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162692 
                 VCAM1 
                 −0.978 
                 4.776 
                 −3.512 
                 0.001 
                 0.012 
                 −0.926 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000179431 
                 FJX1 
                 0.997 
                 4.001 
                 3.515 
                 0.001 
                 0.011 
                 −0.871 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162390 
                 ACOT11 
                 0.627 
                 6.456 
                 3.515 
                 0.001 
                 0.011 
                 −0.981 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000205336 
                 ADGRG1 
                 0.803 
                 6.857 
                 3.516 
                 0.001 
                 0.011 
                 −0.970 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000171522 
                 PTGER4 
                 −0.881 
                 4.885 
                 −3.518 
                 0.001 
                 0.011 
                 −0.911 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000104892 
                 KLC3 
                 0.765 
                 4.090 
                 3.520 
                 0.001 
                 0.011 
                 −0.866 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134294 
                 SLC38A2 
                 0.604 
                 9.246 
                 3.520 
                 0.001 
                 0.011 
                 −0.974 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196172 
                 ZNF681 
                 −0.868 
                 3.490 
                 −3.523 
                 0.001 
                 0.011 
                 −0.870 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000177045 
                 SIX5 
                 0.636 
                 3.844 
                 3.525 
                 0.001 
                 0.011 
                 −0.834 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000145287 
                 PLAC8 
                 −1.389 
                 4.704 
                 −3.531 
                 0.001 
                 0.011 
                 −0.881 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000062038 
                 CDH3 
                 1.020 
                 7.105 
                 3.532 
                 0.001 
                 0.011 
                 −0.933 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000187840 
                 EIF4EBP1 
                 0.721 
                 4.405 
                 3.532 
                 0.001 
                 0.011 
                 −0.861 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000110934 
                 BIN2 
                 −0.919 
                 4.508 
                 −3.533 
                 0.001 
                 0.011 
                 −0.823 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000070614 
                 NDST1 
                 0.597 
                 7.473 
                 3.535 
                 0.001 
                 0.011 
                 −0.936 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000105373 
                 GLTSCR2 
                 −0.628 
                 6.838 
                 −3.536 
                 0.001 
                 0.011 
                 −0.922 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143851 
                 PTPN7 
                 −0.729 
                 5.008 
                 −3.537 
                 0.001 
                 0.011 
                 −0.849 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163032 
                 VSNL1 
                 0.919 
                 4.237 
                 3.540 
                 0.001 
                 0.011 
                 −0.823 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000085063 
                 CD59 
                 0.642 
                 7.901 
                 3.542 
                 0.001 
                 0.011 
                 −0.926 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141401 
                 IMPA2 
                 0.838 
                 5.438 
                 3.543 
                 0.001 
                 0.011 
                 −0.831 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000136848 
                 DAB2IP 
                 0.593 
                 6.769 
                 3.541 
                 0.001 
                 0.011 
                 −0.914 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000159496 
                 RGL4 
                 −0.615 
                 3.332 
                 −3.541 
                 0.001 
                 0.011 
                 −0.791 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164938 
                 TP53INP1 
                 −0.804 
                 7.254 
                 −3.547 
                 0.001 
                 0.011 
                 −0.906 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196411 
                 EPHB4 
                 0.633 
                 6.613 
                 3.551 
                 0.001 
                 0.011 
                 −0.893 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000154310 
                 TNIK 
                 −0.678 
                 4.871 
                 −3.552 
                 0.001 
                 0.011 
                 −0.830 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198720 
                 ANKRD13B 
                 0.766 
                 3.620 
                 3.553 
                 0.001 
                 0.011 
                 −0.795 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000178567 
                 EPM2AIP1 
                 −0.603 
                 6.191 
                 −3.553 
                 0.001 
                 0.011 
                 −0.851 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000096696 
                 DSP 
                 1.192 
                 10.538 
                 3.556 
                 0.001 
                 0.011 
                 −0.848 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000120915 
                 EPHX2 
                 −0.711 
                 3.732 
                 −3.555 
                 0.001 
                 0.011 
                 −0.762 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000072840 
                 EVC 
                 0.717 
                 6.006 
                 3.560 
                 0.001 
                 0.011 
                 −0.825 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000176928 
                 GCNT4 
                 −0.964 
                 3.522 
                 −3.560 
                 0.001 
                 0.011 
                 −0.748 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111424 
                 VDR 
                 0.587 
                 5.716 
                 3.558 
                 0.001 
                 0.011 
                 −0.796 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000140398 
                 NEIL1 
                 −0.752 
                 4.745 
                 −3.562 
                 0.001 
                 0.011 
                 −0.770 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000132681 
                 ATP1A4 
                 −0.760 
                 2.588 
                 −3.560 
                 0.001 
                 0.011 
                 −0.726 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000099849 
                 RASSF7 
                 0.673 
                 3.949 
                 3.560 
                 0.001 
                 0.011 
                 −0.759 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000154027 
                 AK5 
                 −0.929 
                 2.111 
                 −3.563 
                 0.001 
                 0.011 
                 −0.719 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000103855 
                 CD276 
                 0.772 
                 6.318 
                 3.570 
                 0.001 
                 0.011 
                 −0.828 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000106479 
                 ZNF862 
                 −0.714 
                 4.693 
                 −3.570 
                 0.001 
                 0.011 
                 −0.745 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000172216 
                 CEBPB 
                 0.677 
                 6.083 
                 3.577 
                 0.001 
                 0.010 
                 −0.786 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134909 
                 ARHGAP32 
                 0.769 
                 6.750 
                 3.582 
                 0.001 
                 0.010 
                 −0.784 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000157551 
                 KCNJ15 
                 1.065 
                 6.175 
                 3.587 
                 0.001 
                 0.010 
                 −0.752 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000182108 
                 DEXI 
                 0.954 
                 3.554 
                 3.588 
                 0.001 
                 0.010 
                 −0.671 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000132793 
                 LPIN3 
                 0.774 
                 5.520 
                 3.588 
                 0.001 
                 0.010 
                 −0.734 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000107099 
                 DOCK8 
                 −0.765 
                 7.251 
                 −3.593 
                 0.001 
                 0.010 
                 −0.770 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000149573 
                 MPZL2 
                 1.101 
                 5.757 
                 3.595 
                 0.001 
                 0.010 
                 −0.685 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000149257 
                 SERPINH1 
                 0.898 
                 7.086 
                 3.595 
                 0.001 
                 0.010 
                 −0.771 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000127528 
                 KLF2 
                 −1.188 
                 5.222 
                 −3.597 
                 0.001 
                 0.010 
                 −0.695 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000158292 
                 GPR153 
                 0.923 
                 5.020 
                 3.598 
                 0.001 
                 0.010 
                 −0.680 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000117984 
                 CTSD 
                 0.646 
                 8.610 
                 3.600 
                 0.001 
                 0.010 
                 −0.768 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000117394 
                 SLC2A1 
                 1.092 
                 8.211 
                 3.602 
                 0.001 
                 0.010 
                 −0.760 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000171867 
                 PRNP 
                 0.719 
                 7.884 
                 3.605 
                 0.001 
                 0.010 
                 −0.752 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000007384 
                 RHBDF1 
                 0.698 
                 4.916 
                 3.603 
                 0.001 
                 0.010 
                 −0.652 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000103044 
                 HAS3 
                 1.449 
                 5.418 
                 3.607 
                 0.001 
                 0.010 
                 −0.695 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197747 
                 S100A10 
                 0.731 
                 7.218 
                 3.608 
                 0.001 
                 0.010 
                 −0.733 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000042980 
                 ADAM28 
                 −1.122 
                 6.025 
                 −3.609 
                 0.001 
                 0.010 
                 −0.728 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197471 
                 SPN 
                 −0.618 
                 5.624 
                 −3.612 
                 0.001 
                 0.010 
                 −0.689 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000109684 
                 CLNK 
                 −0.628 
                 3.073 
                 −3.614 
                 0.001 
                 0.010 
                 −0.594 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000151702 
                 FLI1 
                 −0.680 
                 5.747 
                 −3.619 
                 0.001 
                 0.010 
                 −0.654 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000157379 
                 DHRS1 
                 0.608 
                 5.200 
                 3.618 
                 0.001 
                 0.010 
                 −0.600 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000106948 
                 AKNA 
                 −0.857 
                 7.642 
                 −3.624 
                 0.001 
                 0.010 
                 −0.706 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100027 
                 YPEL1 
                 −0.668 
                 3.522 
                 −3.622 
                 0.001 
                 0.010 
                 −0.590 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000147852 
                 VLDLR 
                 1.420 
                 4.913 
                 3.627 
                 0.001 
                 0.010 
                 −0.601 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000104903 
                 LYL1 
                 −0.794 
                 3.187 
                 −3.627 
                 0.001 
                 0.009 
                 −0.566 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197872 
                 FAM49A 
                 −0.822 
                 4.903 
                 −3.629 
                 0.001 
                 0.009 
                 −0.586 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000095015 
                 MAP3K1 
                 −0.602 
                 6.758 
                 −3.630 
                 0.001 
                 0.009 
                 −0.655 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143537 
                 ADAM15 
                 0.619 
                 6.774 
                 3.635 
                 0.001 
                 0.009 
                 −0.647 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134278 
                 SPIRE1 
                 0.742 
                 5.444 
                 3.638 
                 0.001 
                 0.009 
                 −0.620 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100307 
                 CBX7 
                 −0.768 
                 5.837 
                 −3.644 
                 0.001 
                 0.009 
                 −0.623 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000184205 
                 TSPYL2 
                 −0.845 
                 4.746 
                 −3.647 
                 0.001 
                 0.009 
                 −0.540 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143858 
                 SYT2 
                 −0.662 
                 2.571 
                 −3.648 
                 0.001 
                 0.009 
                 −0.501 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000160654 
                 CD3G 
                 −1.024 
                 4.296 
                 −3.651 
                 0.001 
                 0.009 
                 −0.516 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000172819 
                 RARG 
                 0.736 
                 5.790 
                 3.658 
                 0.001 
                 0.009 
                 −0.568 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000J85989 
                 RASA3 
                 −0.645 
                 5.993 
                 −3.657 
                 0.00J 
                 0.009 
                 −0.567 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000271303 
                 SRXN1 
                 0.815 
                 5.501 
                 3.662 
                 0.001 
                 0.009 
                 −0.529 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134247 
                 PTGFRN 
                 0.783 
                 7.605 
                 3.664 
                 0.001 
                 0.009 
                 −0.593 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000146950 
                 SHROOM2 
                 0.750 
                 4.600 
                 3.665 
                 0.001 
                 0.009 
                 −0.518 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000029153 
                 ARNTL2 
                 0.887 
                 6.565 
                 3.669 
                 0.001 
                 0.009 
                 −0.579 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000158716 
                 DUSP23 
                 0.663 
                 3.095 
                 3.667 
                 0.001 
                 0.009 
                 −0.446 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000161929 
                 SCIMP 
                 −0.760 
                 4.708 
                 −3.672 
                 0.001 
                 0.009 
                 −0.471 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000171680 
                 PLEKHG5 
                 0.784 
                 6.085 
                 3.677 
                 0.001 
                 0.009 
                 −0.533 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000004777 
                 ARHGAP33 
                 −0.937 
                 4.471 
                 −3.680 
                 0.001 
                 0.009 
                 −0.470 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000146757 
                 ZNF92 
                 −0.691 
                 4.281 
                 −3.678 
                 0.001 
                 0.009 
                 −0.444 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000127995 
                 CASD1 
                 −0.596 
                 5.388 
                 −3.682 
                 0.001 
                 0.009 
                 −0.479 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000083857 
                 FAT1 
                 0.748 
                 8.996 
                 3.687 
                 0.001 
                 0.009 
                 −0.520 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000153814 
                 JAZF1 
                 −0.620 
                 4.842 
                 −3.688 
                 0.001 
                 0.008 
                 −0.435 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000108679 
                 LGALS3BP 
                 0.641 
                 7.639 
                 3.691 
                 0.001 
                 0.008 
                 −0.522 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000173801 
                 JUP 
                 1.129 
                 8.792 
                 3.692 
                 0.001 
                 0.008 
                 −0.511 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000152582 
                 SPEF2 
                 −0.698 
                 4.379 
                 −3.694 
                 0.001 
                 0.008 
                 −0.419 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000173207 
                 CKS1B 
                 0.598 
                 4.649 
                 3.694 
                 0.001 
                 0.008 
                 −0.417 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000146021 
                 KLHL3 
                 −0.746 
                 4.481 
                 −3.695 
                 0.001 
                 0.008 
                 −0.391 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000140859 
                 KIFC3 
                 0.611 
                 6.109 
                 3.697 
                 0.001 
                 0.008 
                 −0.464 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000147383 
                 NSDHL 
                 0.604 
                 3.599 
                 3.699 
                 0.001 
                 0.008 
                 −0.382 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134317 
                 GRHL1 
                 1.516 
                 5.574 
                 3.707 
                 0.001 
                 0.008 
                 −0.414 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000151883 
                 PARP8 
                 −0.586 
                 6.635 
                 −3.709 
                 0.001 
                 0.008 
                 −0.444 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130489 
                 SCO2 
                 0.938 
                 4.765 
                 3.713 
                 0.001 
                 0.008 
                 −0.373 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000156675 
                 RAB11FIP1 
                 −0.616 
                 6.671 
                 −3.713 
                 0.001 
                 0.008 
                 −0.454 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000213977 
                 TAX1BP3 
                 0.656 
                 6.094 
                 3.723 
                 0.001 
                 0.008 
                 −0.361 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000153283 
                 CD96 
                 −0.898 
                 4.602 
                 −3.729 
                 0.001 
                 0.008 
                 −0.316 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000145545 
                 SRD5A1 
                 0.654 
                 6.465 
                 3.728 
                 0.001 
                 0.008 
                 −0.382 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163219 
                 ARHGAP25 
                 −0.715 
                 5.145 
                 −3.729 
                 0.001 
                 0.008 
                 −0.346 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000182580 
                 EPHB3 
                 0.841 
                 4.798 
                 3.731 
                 0.001 
                 0.008 
                 −0.359 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000091622 
                 PITPNM3 
                 0.878 
                 5.210 
                 3.732 
                 0.001 
                 0.008 
                 −0.359 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100320 
                 RBFOX2 
                 0.633 
                 7.099 
                 3.731 
                 0.001 
                 0.008 
                 −0.409 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198673 
                 FAM19A2 
                 −0.662 
                 2.686 
                 −3.731 
                 0.001 
                 0.008 
                 −0.278 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000135378 
                 PRRG4 
                 0.716 
                 6.128 
                 3.733 
                 0.001 
                 0.008 
                 −0.364 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000089876 
                 DHX32 
                 0.699 
                 5.022 
                 3.732 
                 0.001 
                 0.008 
                 −0.313 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000165655 
                 ZNF503 
                 0.828 
                 4.082 
                 3.735 
                 0.001 
                 0.008 
                 −0.290 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197562 
                 RAB40C 
                 0.602 
                 4.749 
                 3.739 
                 0.001 
                 0.008 
                 −0.297 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000106571 
                 GLI3 
                 0.866 
                 5.930 
                 3.745 
                 0.001 
                 0.008 
                 −0.329 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000187994 
                 RINL 
                 −1.440 
                 4.181 
                 −3.746 
                 0.001 
                 0.008 
                 −0.285 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000126803 
                 HSPA2 
                 1.068 
                 4.861 
                 3.755 
                 0.001 
                 0.008 
                 −0.286 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000118257 
                 NRP2 
                 0.697 
                 6.812 
                 3.755 
                 0.001 
                 0.008 
                 −0.336 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000283652 
                 WDFY4 
                 −1.245 
                 5.915 
                 −3.757 
                 0.001 
                 0.008 
                 −0.287 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000074706 
                 IPCEF1 
                 −1.360 
                 4.468 
                 −3.761 
                 0.001 
                 0.007 
                 −0.232 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000127564 
                 PKMYT1 
                 0.887 
                 4.627 
                 3.765 
                 0.001 
                 0.007 
                 −0.227 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000169504 
                 CLIC4 
                 0.735 
                 7.964 
                 3.767 
                 0.001 
                 0.007 
                 −0.316 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130517 
                 PGPEP1 
                 −0.648 
                 5.549 
                 −3.770 
                 0.001 
                 0.007 
                 −0.260 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000166681 
                 BEX3 
                 0.773 
                 4.529 
                 3.776 
                 0.001 
                 0.007 
                 −0.198 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000158220 
                 ESYT3 
                 0.855 
                 3.295 
                 3.780 
                 0.000 
                 0.007 
                 −0.174 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141736 
                 ERBB2 
                 0.736 
                 6.726 
                 3.781 
                 0.000 
                 0.007 
                 −0.263 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000152684 
                 PELO 
                 0.597 
                 4.472 
                 3.780 
                 0.000 
                 0.007 
                 −0.186 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000082293 
                 COL19A1 
                 −1.331 
                 3.185 
                 −3.786 
                 0.000 
                 0.007 
                 −0.151 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000157227 
                 MMP14 
                 0.890 
                 8.070 
                 3.788 
                 0.000 
                 0.007 
                 −0.249 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000078900 
                 TP73 
                 0.797 
                 3.972 
                 3.790 
                 0.000 
                 0.007 
                 −0.192 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164398 
                 ACSL6 
                 −1.329 
                 3.251 
                 −3.791 
                 0.000 
                 0.007 
                 −0.127 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000128309 
                 MPST 
                 0.637 
                 5.345 
                 3.788 
                 0.000 
                 0.007 
                 −0.194 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000096996 
                 IL12RB1 
                 −0.702 
                 4.014 
                 −3.789 
                 0.000 
                 0.007 
                 −0.144 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000168297 
                 PXK 
                 −0.719 
                 5.035 
                 −3.791 
                 0.000 
                 0.007 
                 −0.170 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000171517 
                 LPAR3 
                 1.403 
                 4.947 
                 3.797 
                 0.000 
                 0.007 
                 −0.129 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000147168 
                 IL2RG 
                 −0.888 
                 4.862 
                 −3.802 
                 0.000 
                 0.007 
                 −0.132 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000168487 
                 BMP1 
                 0.763 
                 6.199 
                 3.803 
                 0.000 
                 0.007 
                 −0.186 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000266714 
                 MYO15B 
                 −0.683 
                 6.827 
                 −3.803 
                 0.000 
                 0.007 
                 −0.208 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142910 
                 TINAGL1 
                 0.737 
                 6.304 
                 3.804 
                 0.000 
                 0.007 
                 −0.181 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000213654 
                 GPSM3 
                 −0.821 
                 4.580 
                 −3.807 
                 0.000 
                 0.007 
                 −0.104 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130635 
                 COL5A1 
                 1.097 
                 9.463 
                 3.815 
                 0.000 
                 0.007 
                 −0.176 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000155380 
                 SLC16A1 
                 1.045 
                 6.332 
                 3.815 
                 0.000 
                 0.007 
                 −0.136 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000087589 
                 CASS4 
                 −0.654 
                 3.162 
                 −3.815 
                 0.000 
                 0.007 
                 −0.056 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000179933 
                 C14orf119 
                 0.651 
                 4.817 
                 3.819 
                 0.000 
                 0.007 
                 −0.062 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000203950 
                 FAM127B 
                 0.593 
                 3.791 
                 3.822 
                 0.000 
                 0.007 
                 −0.042 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000008283 
                 CYB561 
                 0.641 
                 5.771 
                 3.828 
                 0.000 
                 0.007 
                 −0.100 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000131018 
                 SYNE1 
                 −0.629 
                 7.671 
                 −3.830 
                 0.000 
                 0.007 
                 −0.133 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000147955 
                 SIGMAR1 
                 0.674 
                 5.254 
                 3.831 
                 0.000 
                 0.007 
                 −0.030 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000066322 
                 ELOVL1 
                 0.747 
                 5.529 
                 3.833 
                 0.000 
                 0.007 
                 −0.050 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000182704 
                 TSKU 
                 0.620 
                 6.606 
                 3.834 
                 0.000 
                 0.007 
                 −0.085 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000189233 
                 NUGGC 
                 −0.902 
                 3.838 
                 −3.841 
                 0.000 
                 0.007 
                 −0.002 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000101265 
                 RASSF2 
                 −0.943 
                 6.133 
                 −3.844 
                 0.000 
                 0.006 
                 −0.058 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197943 
                 PLCG2 
                 −1.080 
                 5.984 
                 −3.844 
                 0.000 
                 0.006 
                 −0.044 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000266094 
                 RASSF5 
                 −0.805 
                 6.409 
                 −3.846 
                 0.000 
                 0.006 
                 −0.065 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197134 
                 ZNF257 
                 −0.609 
                 2.637 
                 −3.853 
                 0.000 
                 0.006 
                 0.047 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142675 
                 CNKSR1 
                 0.727 
                 4.171 
                 3.855 
                 0.000 
                 0.006 
                 0.027 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000180448 
                 ARHGAP45 
                 −0.868 
                 6.594 
                 −3.859 
                 0.000 
                 0.006 
                 −0.041 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134352 
                 IL6ST 
                 −0.751 
                 8.576 
                 −3.860 
                 0.000 
                 0.006 
                 −0.059 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000105520 
                 PLPPR2 
                 0.710 
                 4.426 
                 3.857 
                 0.000 
                 0.006 
                 0.043 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196511 
                 TPK1 
                 −0.810 
                 4.042 
                 −3.859 
                 0.000 
                 0.006 
                 0.049 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000125170 
                 DOK4 
                 1.029 
                 3.951 
                 3.862 
                 0.000 
                 0.006 
                 0.059 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000181513 
                 ACBD4 
                 −0.622 
                 3.403 
                 −3.872 
                 0.000 
                 0.006 
                 0.091 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000102796 
                 DHRS12 
                 −0.717 
                 3.306 
                 −3.874 
                 0.000 
                 0.006 
                 0.104 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137460 
                 FHDC1 
                 0.875 
                 4.950 
                 3.878 
                 0.000 
                 0.006 
                 0.050 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000186469 
                 GNG2 
                 −0.738 
                 5.157 
                 −3.883 
                 0.000 
                 0.006 
                 0.099 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000110092 
                 CCND1 
                 0.891 
                 8.273 
                 3.896 
                 0.000 
                 0.006 
                 0.092 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000120278 
                 PLEKHG1 
                 −0.620 
                 5.815 
                 −3.893 
                 0.000 
                 0.006 
                 0.055 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130653 
                 PNPLA7 
                 −0.918 
                 4.295 
                 −3.899 
                 0.000 
                 0.006 
                 0.148 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134242 
                 PTPN22 
                 −0.791 
                 4.137 
                 −3.903 
                 0.000 
                 0.006 
                 0.172 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000257950 
                 P2RX5- 
                 −0.662 
                 4.207 
                 −3.905 
                 0.000 
                 0.006 
                 0.167 
               
               
                   
                   
                 TAX1BP3 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000168918 
                 INPP5D 
                 −1.100 
                 6.562 
                 −3.914 
                 0.000 
                 0.006 
                 0.137 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000125968 
                 ID1 
                 1.073 
                 5.394 
                 3.918 
                 0.000 
                 0.006 
                 0.183 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000128815 
                 WDFY4 
                 −1.239 
                 4.967 
                 −3.919 
                 0.000 
                 0.006 
                 0.189 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000181035 
                 SLC25A42 
                 −0.595 
                 3.901 
                 −3.918 
                 0.000 
                 0.005 
                 0.208 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000185477 
                 GPRIN3 
                 −0.754 
                 6.767 
                 −3.924 
                 0.000 
                 0.005 
                 0.136 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000139433 
                 GLTP 
                 0.868 
                 6.583 
                 3.925 
                 0.000 
                 0.005 
                 0.135 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000140968 
                 IRF8 
                 −1.305 
                 5.673 
                 −3.927 
                 0.000 
                 0.005 
                 0.191 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000139926 
                 FRMD6 
                 0.977 
                 7.262 
                 3.931 
                 0.000 
                 0.005 
                 0.152 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000175463 
                 TBC1D10C 
                 −1.054 
                 5.212 
                 −3.932 
                 0.000 
                 0.005 
                 0.197 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000174607 
                 UGT8 
                 −0.816 
                 4.476 
                 −3.933 
                 0.000 
                 0.005 
                 0.197 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134516 
                 DOCK2 
                 −1.038 
                 6.540 
                 −3.936 
                 0.000 
                 0.005 
                 0.204 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000076641 
                 PAG1 
                 −0.735 
                 6.732 
                 −3.936 
                 0.000 
                 0.005 
                 0.184 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000157734 
                 SNX22 
                 −0.878 
                 4.420 
                 −3.938 
                 0.000 
                 0.005 
                 0.229 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138119 
                 MYOF 
                 0.693 
                 7.897 
                 3.941 
                 0.000 
                 0.005 
                 0.172 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000145882 
                 PCYOX1L 
                 −0.705 
                 4.087 
                 −3.940 
                 0.000 
                 0.005 
                 0.277 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000132470 
                 ITGB4 
                 0.870 
                 8.923 
                 3.949 
                 0.000 
                 0.005 
                 0.202 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162729 
                 IGSF8 
                 0.598 
                 4.653 
                 3.948 
                 0.000 
                 0.005 
                 0.271 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000154845 
                 PPP4R1 
                 0.678 
                 7.340 
                 3.953 
                 0.000 
                 0.005 
                 0.214 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000131969 
                 ABHD12B 
                 0.830 
                 3.533 
                 3.958 
                 0.000 
                 0.005 
                 0.276 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000007944 
                 MYLIP 
                 −0.831 
                 4.819 
                 −3.960 
                 0.000 
                 0.005 
                 0.287 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000110723 
                 EXPH5 
                 1.002 
                 5.394 
                 3.961 
                 0.000 
                 0.005 
                 0.291 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142611 
                 PRDM16 
                 −0.639 
                 2.935 
                 −3.958 
                 0.000 
                 0.005 
                 0.329 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000188177 
                 ZC3H6 
                 −0.661 
                 5.787 
                 −3.958 
                 0.000 
                 0.005 
                 0.284 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000106415 
                 GLCCI1 
                 −0.919 
                 5.225 
                 −3.963 
                 0.000 
                 0.005 
                 0.295 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000140832 
                 MARVELD3 
                 0.631 
                 4.123 
                 3.965 
                 0.000 
                 0.005 
                 0.334 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000161642 
                 ZNF385A 
                 0.818 
                 5.889 
                 3.968 
                 0.000 
                 0.005 
                 0.300 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000122642 
                 FKBP9 
                 0.720 
                 6.817 
                 3.970 
                 0.000 
                 0.005 
                 0.256 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000136490 
                 LIMD2 
                 −0.956 
                 5.560 
                 −3.970 
                 0.000 
                 0.005 
                 0.280 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000169242 
                 EFNA1 
                 1.139 
                 4.993 
                 3.971 
                 0.000 
                 0.005 
                 0.335 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141424 
                 SLC39A6 
                 0.705 
                 6.122 
                 3.972 
                 0.000 
                 0.005 
                 0.300 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142627 
                 EPHA2 
                 0.993 
                 6.140 
                 3.977 
                 0.000 
                 0.005 
                 0.278 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143842 
                 SOX13 
                 0.631 
                 5.384 
                 3.975 
                 0.000 
                 0.005 
                 0.318 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167693 
                 NXN 
                 0.718 
                 6.142 
                 3.979 
                 0.000 
                 0.005 
                 0.291 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000114770 
                 ABCC5 
                 0.613 
                 7.369 
                 3.977 
                 0.000 
                 0.005 
                 0.280 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000158258 
                 CLSTN2 
                 −1.266 
                 4.276 
                 −3.982 
                 0.000 
                 0.005 
                 0.370 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000072858 
                 SIDT1 
                 −0.921 
                 4.705 
                 −3.982 
                 0.000 
                 0.005 
                 0.367 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000122026 
                 RPL21 
                 −0.655 
                 7.932 
                 −3.982 
                 0.000 
                 0.005 
                 0.291 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100523 
                 DDHD1 
                 −0.694 
                 6.954 
                 −3.983 
                 0.000 
                 0.005 
                 0.303 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000048740 
                 CELF2 
                 −0.962 
                 7.011 
                 −3.985 
                 0.000 
                 0.005 
                 0.326 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000114841 
                 DNAH1 
                 −1.114 
                 6.344 
                 −3.987 
                 0.000 
                 0.005 
                 0.309 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000159166 
                 LAD1 
                 0.971 
                 6.931 
                 3.988 
                 0.000 
                 0.005 
                 0.304 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000175567 
                 UCP2 
                 −0.869 
                 5.557 
                 −3.989 
                 0.000 
                 0.005 
                 0.362 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000135540 
                 NHSL1 
                 0.735 
                 6.040 
                 3.989 
                 0.000 
                 0.005 
                 0.316 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130396 
                 MLLT4 
                 0.642 
                 7.511 
                 3.988 
                 0.000 
                 0.005 
                 0.307 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000077684 
                 JADE1 
                 −0.920 
                 5.467 
                 −3.993 
                 0.000 
                 0.005 
                 0.367 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167130 
                 DOLPP1 
                 0.627 
                 3.848 
                 3.995 
                 0.000 
                 0.005 
                 0.420 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142733 
                 MAP3K6 
                 0.638 
                 5.753 
                 3.996 
                 0.000 
                 0.005 
                 0.363 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000172578 
                 KLHL6 
                 −0.823 
                 6.365 
                 −4.003 
                 0.000 
                 0.005 
                 0.376 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000139324 
                 TMTC3 
                 0.698 
                 6.592 
                 4.003 
                 0.000 
                 0.005 
                 0.360 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000275832 
                 ARHGAP23 
                 0.614 
                 6.815 
                 4.010 
                 0.000 
                 0.005 
                 0.375 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116141 
                 MARK1 
                 1.249 
                 4.723 
                 4.014 
                 0.000 
                 0.005 
                 0.408 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000011105 
                 TSPAN9 
                 0.679 
                 5.692 
                 4.011 
                 0.000 
                 0.005 
                 0.417 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137177 
                 KIF13A 
                 0.589 
                 7.009 
                 4.011 
                 0.000 
                 0.005 
                 0.386 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000165300 
                 SLITRK5 
                 −0.625 
                 2.816 
                 −4.013 
                 0.000 
                 0.005 
                 0.474 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000088986 
                 DYNLL1 
                 0.673 
                 6.175 
                 4.014 
                 0.000 
                 0.005 
                 0.414 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000175832 
                 ETV4 
                 0.835 
                 3.719 
                 4.016 
                 0.000 
                 0.005 
                 0.460 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000156136 
                 DCK 
                 −0.840 
                 5.740 
                 −4.027 
                 0.000 
                 0.005 
                 0.453 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000166908 
                 PIP4K2C 
                 0.708 
                 5.499 
                 4.027 
                 0.000 
                 0.005 
                 0.471 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000069812 
                 HES2 
                 1.457 
                 5.193 
                 4.031 
                 0.000 
                 0.005 
                 0.503 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000145416 
                 MARCH1 
                 −0.695 
                 6.187 
                 −4.031 
                 0.000 
                 0.005 
                 0.456 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000056558 
                 TRAF1 
                 −0.820 
                 5.965 
                 −4.036 
                 0.000 
                 0.005 
                 0.463 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000110448 
                 CD5 
                 −1.202 
                 4.630 
                 −4.036 
                 0.000 
                 0.005 
                 0.499 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000105613 
                 MAST1 
                 −0.620 
                 2.463 
                 −4.040 
                 0.000 
                 0.004 
                 0.554 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198521 
                 ZNF43 
                 −0.708 
                 4.885 
                 −4.041 
                 0.000 
                 0.004 
                 0.538 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141579 
                 ZNF750 
                 0.993 
                 5.138 
                 4.045 
                 0.000 
                 0.004 
                 0.513 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000215252 
                 GOLGA8B 
                 −0.706 
                 7.421 
                 −4.045 
                 0.000 
                 0.004 
                 0.469 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162073 
                 PAQR4 
                 0.671 
                 4.207 
                 4.045 
                 0.000 
                 0.004 
                 0.554 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000110218 
                 PANX1 
                 0.736 
                 5.132 
                 4.046 
                 0.000 
                 0.004 
                 0.544 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000148057 
                 IDNK 
                 −0.825 
                 2.682 
                 −4.047 
                 0.000 
                 0.004 
                 0.572 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000161835 
                 GRASP 
                 −0.970 
                 4.481 
                 −4.053 
                 0.000 
                 0.004 
                 0.539 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000135631 
                 RAB11FIP5 
                 0.702 
                 5.639 
                 4.060 
                 0.000 
                 0.004 
                 0.554 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000133392 
                 MYH11 
                 −1.138 
                 6.163 
                 −4.069 
                 0.000 
                 0.004 
                 0.554 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142632 
                 ARHGEF19 
                 0.776 
                 4.527 
                 4.070 
                 0.000 
                 0.004 
                 0.600 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000150627 
                 WDR17 
                 −0.868 
                 2.701 
                 −4.072 
                 0.000 
                 0.004 
                 0.641 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000213809 
                 KLRK1 
                 −0.653 
                 4.097 
                 −4.072 
                 0.000 
                 0.004 
                 0.633 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000106089 
                 STX1A 
                 0.730 
                 3.374 
                 4.078 
                 0.000 
                 0.004 
                 0.655 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138378 
                 STAT4 
                 −1.150 
                 3.936 
                 −4.084 
                 0.000 
                 0.004 
                 0.660 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000170989 
                 S1PR1 
                 −1.123 
                 4.546 
                 −4.088 
                 0.000 
                 0.004 
                 0.665 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000144182 
                 LIPT1 
                 −0.694 
                 2.905 
                 −4.088 
                 0.000 
                 0.004 
                 0.686 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000047346 
                 FAM214A 
                 −0.707 
                 6.618 
                 −4.091 
                 0.000 
                 0.004 
                 0.613 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198771 
                 RCSD1 
                 −0.911 
                 5.765 
                 −4.098 
                 0.000 
                 0.004 
                 0.650 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000188112 
                 C6orf132 
                 0.819 
                 6.357 
                 4.101 
                 0.000 
                 0.004 
                 0.641 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000107338 
                 SHB 
                 0.883 
                 4.763 
                 4.101 
                 0.000 
                 0.004 
                 0.677 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162852 
                 CNST 
                 −0.624 
                 5.847 
                 −4.099 
                 0.000 
                 0.004 
                 0.659 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000120899 
                 PTK2B 
                 −0.699 
                 6.900 
                 −4.103 
                 0.000 
                 0.004 
                 0.652 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167114 
                 SLC27A4 
                 0.721 
                 5.084 
                 4.104 
                 0.000 
                 0.004 
                 0.711 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000125354 
                 SEP16 
                 −0.884 
                 6.122 
                 −4.110 
                 0.000 
                 0.004 
                 0.684 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000124406 
                 ATP8A1 
                 −1.428 
                 5.412 
                 −4.114 
                 0.000 
                 0.004 
                 0.733 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000180096 
                 SEP11 
                 −1.137 
                 4.486 
                 −4.114 
                 0.000 
                 0.004 
                 0.733 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000174718 
                 KIAA1551 
                 −0.733 
                 7.676 
                 −4.118 
                 0.000 
                 0.004 
                 0.672 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000117877 
                 CD3EAP 
                 0.929 
                 4.051 
                 4.119 
                 0.000 
                 0.004 
                 0.755 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142875 
                 PRKACB 
                 −0.656 
                 6.062 
                 −4.115 
                 0.000 
                 0.004 
                 0.708 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000135905 
                 DOCK10 
                 −0.851 
                 6.688 
                 −4.120 
                 0.000 
                 0.004 
                 0.703 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111348 
                 ARHGDIB 
                 −0.836 
                 6.685 
                 −4.121 
                 0.000 
                 0.004 
                 0.705 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137267 
                 TUBB2A 
                 1.214 
                 4.781 
                 4.124 
                 0.000 
                 0.004 
                 0.755 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000169239 
                 CA5B 
                 −0.640 
                 5.402 
                 −4.121 
                 0.000 
                 0.004 
                 0.744 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000106080 
                 FKBP14 
                 0.639 
                 5.463 
                 4.123 
                 0.000 
                 0.004 
                 0.764 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000135525 
                 MAP7 
                 0.919 
                 4.944 
                 4.129 
                 0.000 
                 0.004 
                 0.748 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000129932 
                 DOHH 
                 0.702 
                 3.120 
                 4.128 
                 0.000 
                 0.004 
                 0.795 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000015133 
                 CCDC88C 
                 −0.805 
                 6.904 
                 −4.140 
                 0.000 
                 0.004 
                 0.735 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000182866 
                 LCK 
                 −0.875 
                 4.395 
                 −4.139 
                 0.000 
                 0.004 
                 0.795 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000174307 
                 PHLDA3 
                 0.811 
                 5.265 
                 4.142 
                 0.000 
                 0.004 
                 0.785 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000183762 
                 KREMEN1 
                 0.809 
                 6.523 
                 4.144 
                 0.000 
                 0.004 
                 0.747 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000183813 
                 CCR4 
                 −0.866 
                 4.456 
                 −4.147 
                 0.000 
                 0.004 
                 0.835 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000121895 
                 TMEM156 
                 −0.959 
                 3.444 
                 −4.149 
                 0.000 
                 0.004 
                 0.847 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000117020 
                 AKT3 
                 −0.766 
                 6.297 
                 −4.150 
                 0.000 
                 0.004 
                 0.798 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000104881 
                 PPP1R13L 
                 0.819 
                 6.737 
                 4.152 
                 0.000 
                 0.004 
                 0.797 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000159348 
                 CYB5R1 
                 1.033 
                 5.471 
                 4.155 
                 0.000 
                 0.004 
                 0.841 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000160223 
                 ICOSLG 
                 −0.739 
                 5.371 
                 −4.153 
                 0.000 
                 0.004 
                 0.809 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100100 
                 PIK3IP1 
                 −1.021 
                 6.385 
                 −4.160 
                 0.000 
                 0.004 
                 0.819 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000102053 
                 ZC3H12B 
                 −0.620 
                 3.430 
                 −4.157 
                 0.000 
                 0.004 
                 0.873 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000180921 
                 FAM83H 
                 0.830 
                 7.453 
                 4.162 
                 0.000 
                 0.004 
                 0.799 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164045 
                 CDC25A 
                 0.815 
                 3.298 
                 4.161 
                 0.000 
                 0.004 
                 0.882 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000182183 
                 FAM159A 
                 −1.077 
                 3.510 
                 −4.166 
                 0.000 
                 0.004 
                 0.887 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162522 
                 KIAA1522 
                 0.834 
                 7.300 
                 4.166 
                 0.000 
                 0.004 
                 0.810 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167880 
                 EVPL 
                 1.008 
                 6.399 
                 4.166 
                 0.000 
                 0.004 
                 0.823 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000160213 
                 CSTB 
                 1.125 
                 6.592 
                 4.176 
                 0.000 
                 0.004 
                 0.860 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000205476 
                 CCDC85C 
                 0.623 
                 6.726 
                 4.176 
                 0.000 
                 0.004 
                 0.866 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000125912 
                 NCLN 
                 0.652 
                 6.070 
                 4.178 
                 0.000 
                 0.004 
                 0.880 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143643 
                 TTC13 
                 −0.622 
                 4.730 
                 −4.178 
                 0.000 
                 0.004 
                 0.925 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000115896 
                 PLCL1 
                 −0.866 
                 3.573 
                 −4.179 
                 0.000 
                 0.004 
                 0.936 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000150867 
                 PIP4K2A 
                 −0.715 
                 6.207 
                 −4.191 
                 0.000 
                 0.003 
                 0.932 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000131067 
                 GGT7 
                 −0.778 
                 3.705 
                 −4.195 
                 0.000 
                 0.003 
                 0.974 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000188822 
                 CNR2 
                 −1.002 
                 4.132 
                 −4.199 
                 0.000 
                 0.003 
                 0.974 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167895 
                 TMC8 
                 −1.135 
                 6.024 
                 −4.199 
                 0.000 
                 0.003 
                 0.934 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000108179 
                 PPIF 
                 0.915 
                 6.371 
                 4.201 
                 0.000 
                 0.003 
                 0.933 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167037 
                 SGSM1 
                 −1.024 
                 2.684 
                 −4.203 
                 0.000 
                 0.003 
                 0.989 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000239521 
                 GATS 
                 −0.935 
                 4.831 
                 −4.207 
                 0.000 
                 0.003 
                 0.978 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000073711 
                 PPP2R3A 
                 0.781 
                 6.041 
                 4.206 
                 0.000 
                 0.003 
                 0.954 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000132704 
                 FCRL2 
                 −1.190 
                 4.061 
                 −4.208 
                 0.000 
                 0.003 
                 0.999 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000097021 
                 ACOT7 
                 0.814 
                 4.464 
                 4.211 
                 0.000 
                 0.003 
                 1.006 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000178199 
                 ZC3H12D 
                 −0.992 
                 5.381 
                 −4.216 
                 0.000 
                 0.003 
                 1.003 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000123159 
                 GIPC1 
                 0.842 
                 6.206 
                 4.218 
                 0.000 
                 0.003 
                 0.983 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000112294 
                 ALDH5A1 
                 −1.003 
                 4.292 
                 −4.219 
                 0.000 
                 0.003 
                 1.015 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000131788 
                 PIAS3 
                 0.652 
                 6.048 
                 4.215 
                 0.000 
                 0.003 
                 0.997 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000010278 
                 CD9 
                 0.840 
                 6.755 
                 4.219 
                 0.000 
                 0.003 
                 0.968 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000152484 
                 USP12 
                 −0.626 
                 6.016 
                 −4.215 
                 0.000 
                 0.003 
                 0.999 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000126860 
                 EVI2A 
                 −0.747 
                 4.368 
                 −4.227 
                 0.000 
                 0.003 
                 1.067 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000073849 
                 ST6GAL1 
                 −1.035 
                 6.799 
                 −4.232 
                 0.000 
                 0.003 
                 1.005 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000129675 
                 ARHGEF6 
                 −0.843 
                 5.572 
                 −4.232 
                 0.000 
                 0.003 
                 1.065 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000185340 
                 GAS2L1 
                 0.867 
                 4.820 
                 4.233 
                 0.000 
                 0.003 
                 1.073 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000025708 
                 TYMP 
                 0.791 
                 7.828 
                 4.236 
                 0.000 
                 0.003 
                 1.023 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000136802 
                 LRRC8A 
                 0.725 
                 7.046 
                 4.239 
                 0.000 
                 0.003 
                 1.028 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000104894 
                 CD37 
                 −1.219 
                 5.981 
                 −4.245 
                 0.000 
                 0.003 
                 1.067 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000128283 
                 CDC42EP1 
                 0.921 
                 5.637 
                 4.248 
                 0.000 
                 0.003 
                 1.087 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000114993 
                 RTKN 
                 0.841 
                 5.332 
                 4.247 
                 0.000 
                 0.003 
                 1.096 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000187838 
                 TMEM256- 
                 0.741 
                 5.276 
                 4.249 
                 0.000 
                 0.003 
                 1.104 
               
               
                   
                   
                 PLSCR3 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000007866 
                 TEAD3 
                 0.856 
                 5.445 
                 4.253 
                 0.000 
                 0.003 
                 1.105 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000179761 
                 PIPOX 
                 −0.825 
                 2.630 
                 −4.250 
                 0.000 
                 0.003 
                 1.134 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000213853 
                 EMP2 
                 0.629 
                 7.156 
                 4.250 
                 0.000 
                 0.003 
                 1.070 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000177954 
                 RPS27 
                 −0.769 
                 7.559 
                 −4.254 
                 0.000 
                 0.003 
                 1.071 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000126822 
                 PLEKHG3 
                 1.151 
                 6.938 
                 4.257 
                 0.000 
                 0.003 
                 1.079 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000140577 
                 CRTC3 
                 −0.593 
                 6.519 
                 −4.261 
                 0.000 
                 0.003 
                 1.104 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000053702 
                 NRIP2 
                 −0.595 
                 4.002 
                 −4.262 
                 0.000 
                 0.003 
                 1.160 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000171467 
                 ZNF318 
                 −0.910 
                 6.558 
                 −4.268 
                 0.000 
                 0.003 
                 1.110 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000173698 
                 ADGRG2 
                 −0.654 
                 3.974 
                 −4.265 
                 0.000 
                 0.003 
                 1.173 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000023445 
                 BIRC3 
                 −1.023 
                 7.738 
                 −4.271 
                 0.000 
                 0.003 
                 1.112 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141968 
                 VAV1 
                 −0.639 
                 4.844 
                 −4.267 
                 0.000 
                 0.003 
                 1.160 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116852 
                 KIF21B 
                 −0.760 
                 5.481 
                 −4.269 
                 0.000 
                 0.003 
                 1.147 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000115935 
                 WIPF1 
                 −0.752 
                 7.390 
                 −4.272 
                 0.000 
                 0.003 
                 1.119 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000055163 
                 CYFIP2 
                 −1.248 
                 5.674 
                 −4.275 
                 0.000 
                 0.003 
                 1.167 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000155629 
                 PIK3AP1 
                 −0.864 
                 5.975 
                 −4.276 
                 0.000 
                 0.003 
                 1.144 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164086 
                 DUSP7 
                 0.926 
                 6.203 
                 4.277 
                 0.000 
                 0.003 
                 1.163 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100504 
                 PYGL 
                 0.996 
                 6.335 
                 4.280 
                 0.000 
                 0.003 
                 1.178 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000074966 
                 TXK 
                 −1.391 
                 3.750 
                 −4.282 
                 0.000 
                 0.003 
                 1.215 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138336 
                 TET1 
                 −0.720 
                 3.684 
                 −4.279 
                 0.000 
                 0.003 
                 1.213 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000148700 
                 ADD3 
                 −0.686 
                 7.000 
                 −4.280 
                 0.000 
                 0.003 
                 1.158 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000152818 
                 UTRN 
                 −0.597 
                 8.580 
                 −4.282 
                 0.000 
                 0.003 
                 1.158 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000115165 
                 CYTIP 
                 −1.146 
                 5.726 
                 −4.290 
                 0.000 
                 0.003 
                 1.214 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000206579 
                 XKR4 
                 −1.580 
                 3.711 
                 −4.292 
                 0.000 
                 0.003 
                 1.243 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000063660 
                 GPC1 
                 0.834 
                 7.396 
                 4.294 
                 0.000 
                 0.003 
                 1.182 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000249242 
                 TMEM150C 
                 −0.753 
                 3.301 
                 −4.293 
                 0.000 
                 0.003 
                 1.253 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000132182 
                 NUP210 
                 −0.836 
                 6.513 
                 −4.302 
                 0.000 
                 0.003 
                 1.208 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198482 
                 ZNF808 
                 −0.635 
                 4.847 
                 −4.298 
                 0.000 
                 0.003 
                 1.238 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000237440 
                 ZNF737 
                 −0.769 
                 3.684 
                 −4.300 
                 0.000 
                 0.003 
                 1.275 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000099814 
                 CEP170B 
                 0.906 
                 6.968 
                 4.305 
                 0.000 
                 0.003 
                 1.217 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000154380 
                 ENAH 
                 0.833 
                 8.030 
                 4.307 
                 0.000 
                 0.003 
                 1.216 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000008513 
                 ST3GAL1 
                 −0.640 
                 6.733 
                 −4.306 
                 0.000 
                 0.003 
                 1.227 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197629 
                 MPEG1 
                 −0.957 
                 6.038 
                 −4.313 
                 0.000 
                 0.003 
                 1.270 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000121957 
                 GPSM2 
                 0.776 
                 6.699 
                 4.313 
                 0.000 
                 0.003 
                 1.246 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000120885 
                 CLU 
                 −1.925 
                 6.021 
                 −4.316 
                 0.000 
                 0.003 
                 1.264 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198018 
                 ENTPD7 
                 0.614 
                 5.635 
                 4.315 
                 0.000 
                 0.003 
                 1.306 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000179841 
                 AKAP5 
                 −0.652 
                 4.433 
                 −4.318 
                 0.000 
                 0.003 
                 1.323 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197780 
                 TAF13 
                 0.696 
                 4.485 
                 4.323 
                 0.000 
                 0.003 
                 1.336 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000185862 
                 EVI2B 
                 −0.892 
                 5.092 
                 −4.332 
                 0.000 
                 0.003 
                 1.350 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000027075 
                 PRKCH 
                 −0.662 
                 6.399 
                 −4.333 
                 0.000 
                 0.003 
                 1.326 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000161405 
                 IKZF3 
                 −1.204 
                 7.038 
                 −4.339 
                 0.000 
                 0.003 
                 1.326 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000103335 
                 PIEZO1 
                 0.593 
                 8.317 
                 4.336 
                 0.000 
                 0.003 
                 1.311 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142065 
                 ZFP14 
                 −0.848 
                 5.012 
                 −4.338 
                 0.000 
                 0.003 
                 1.362 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198945 
                 L3MBTL3 
                 −0.793 
                 4.120 
                 −4.337 
                 0.000 
                 0.003 
                 1.373 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000158710 
                 TAGLN2 
                 0.642 
                 8.278 
                 4.342 
                 0.000 
                 0.003 
                 1.331 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000065485 
                 PDIA5 
                 0.857 
                 4.771 
                 4.347 
                 0.000 
                 0.003 
                 1.375 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116663 
                 FBXO6 
                 0.786 
                 3.493 
                 4.351 
                 0.000 
                 0.003 
                 1.419 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000081237 
                 PTPRC 
                 −1.104 
                 7.711 
                 −4.360 
                 0.000 
                 0.003 
                 1.377 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137502 
                 RAB30 
                 −0.911 
                 5.630 
                 −4.361 
                 0.000 
                 0.003 
                 1.412 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000101695 
                 RNF125 
                 −1.042 
                 5.013 
                 −4.374 
                 0.000 
                 0.003 
                 1.463 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000129250 
                 KIF1C 
                 0.652 
                 7.432 
                 4.375 
                 0.000 
                 0.003 
                 1.431 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000242372 
                 EIF6 
                 0.681 
                 5.571 
                 4.382 
                 0.000 
                 0.002 
                 1.489 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000065413 
                 ANKRD44 
                 −1.215 
                 6.328 
                 −4.387 
                 0.000 
                 0.002 
                 1.472 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000213903 
                 LTB4R 
                 1.129 
                 5.911 
                 4.388 
                 0.000 
                 0.002 
                 1.510 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000178971 
                 CTC1 
                 −0.637 
                 5.953 
                 −4.395 
                 0.000 
                 0.002 
                 1.509 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163644 
                 PPM1K 
                 −0.894 
                 6.580 
                 −4.400 
                 0.000 
                 0.002 
                 1.497 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000155849 
                 ELMO1 
                 −0.856 
                 5.964 
                 −4.409 
                 0.000 
                 0.002 
                 1.542 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000178852 
                 EFCAB13 
                 −0.839 
                 4.397 
                 −4.411 
                 0.000 
                 0.002 
                 1.588 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116191 
                 RALGPS2 
                 −0.846 
                 6.321 
                 −4.415 
                 0.000 
                 0.002 
                 1 560 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000126432 
                 PRDX5 
                 0.589 
                 5.608 
                 4.412 
                 0.000 
                 0.002 
                 1.585 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000181007 
                 ZFP82 
                 −0.592 
                 3.630 
                 −4.413 
                 0.000 
                 0.002 
                 1.596 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111913 
                 FAM65B 
                 −1.529 
                 6.221 
                 −4.418 
                 0.000 
                 0.002 
                 1.569 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000020633 
                 RUNX3 
                 −0.664 
                 6.066 
                 −4.417 
                 0.000 
                 0.002 
                 1.554 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000216937 
                 CCDC7 
                 −0.908 
                 3.695 
                 −4.417 
                 0.000 
                 0.002 
                 1.606 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000204103 
                 MAFB 
                 0.823 
                 6.556 
                 4.420 
                 0.000 
                 0.002 
                 1.583 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142089 
                 IFITM3 
                 0.720 
                 7.273 
                 4.420 
                 0.000 
                 0.002 
                 1.558 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164970 
                 FAM219A 
                 0.716 
                 5.216 
                 4.424 
                 0.000 
                 0.002 
                 1.619 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111224 
                 PARP11 
                 −0.643 
                 5.165 
                 −4.427 
                 0.000 
                 0.002 
                 1.624 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000166974 
                 MAPRE2 
                 −0.722 
                 5.277 
                 −4.440 
                 0.000 
                 0.002 
                 1.663 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000081059 
                 TCF7 
                 −0.992 
                 6.367 
                 −4.450 
                 0.000 
                 0.002 
                 1.642 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000166394 
                 CYB5R2 
                 1.043 
                 4.792 
                 4.452 
                 0.000 
                 0.002 
                 1.671 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000075884 
                 ARHGAP15 
                 −1.209 
                 5.701 
                 −4.455 
                 0.000 
                 0.002 
                 1.688 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138639 
                 ARHGAP24 
                 −1.084 
                 4.763 
                 −4.458 
                 0.000 
                 0.002 
                 1.696 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142102 
                 ATHL1 
                 −0.783 
                 6.653 
                 −4.456 
                 0.000 
                 0.002 
                 1.669 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000144218 
                 AFF3 
                 −1.721 
                 4.918 
                 −4.460 
                 0.000 
                 0.002 
                 1.702 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000174428 
                 GTF2IRD2B 
                 −0.691 
                 4.989 
                 −4.459 
                 0.000 
                 0.002 
                 1.721 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162241 
                 SLC25A45 
                 −0.682 
                 5.265 
                 −4.460 
                 0.000 
                 0.002 
                 1.713 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130733 
                 YIPF2 
                 0.695 
                 4.801 
                 4.461 
                 0.000 
                 0.002 
                 1.727 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111276 
                 CDKN1B 
                 −0.593 
                 6.005 
                 −4.470 
                 0.000 
                 0.002 
                 1.732 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000276023 
                 DUSP14 
                 1.086 
                 4.567 
                 4.480 
                 0.000 
                 0.002 
                 1.775 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000091490 
                 SEL1L3 
                 −1.057 
                 6.742 
                 −4.481 
                 0.000 
                 0.002 
                 1.738 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000189060 
                 H1F0 
                 1.037 
                 6.906 
                 4.482 
                 0.000 
                 0.002 
                 1.755 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000073282 
                 TP63 
                 1.040 
                 8.375 
                 4.489 
                 0.000 
                 0.002 
                 1.752 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130475 
                 FCHO1 
                 −0.856 
                 3.866 
                 −4.486 
                 0.000 
                 0.002 
                 1.806 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000213906 
                 LTB4R2 
                 1.154 
                 5.059 
                 4.497 
                 0.000 
                 0.002 
                 1.823 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000155893 
                 PXYLP1 
                 −0.790 
                 4.930 
                 −4.497 
                 0.000 
                 0.002 
                 1.816 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111669 
                 TPI1 
                 0.625 
                 7.969 
                 4.503 
                 0.000 
                 0.002 
                 1.805 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000122986 
                 HVCN1 
                 −0.940 
                 3.889 
                 −4.506 
                 0.000 
                 0.002 
                 1.857 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000078687 
                 TNRC6C 
                 −0.839 
                 6.109 
                 −4.510 
                 0.000 
                 0.002 
                 1.822 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000169499 
                 PLEKHA2 
                 −0.693 
                 7.164 
                 −4.509 
                 0.000 
                 0.002 
                 1.824 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000084207 
                 GSTP1 
                 0.679 
                 7.830 
                 4.509 
                 0.000 
                 0.002 
                 1.822 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000108370 
                 RGS9 
                 −0.897 
                 3.862 
                 −4.509 
                 0.000 
                 0.002 
                 1.871 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000152270 
                 PDE3B 
                 −1.391 
                 5.979 
                 −4.534 
                 0.000 
                 0.002 
                 1.894 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000084070 
                 SMAP2 
                 −0.936 
                 7.092 
                 −4.537 
                 0.000 
                 0.002 
                 1.905 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000085733 
                 CTTN 
                 0.625 
                 8.342 
                 4.537 
                 0.000 
                 0.002 
                 1.919 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000083444 
                 PLOD1 
                 0.809 
                 6.368 
                 4.555 
                 0.000 
                 0.002 
                 1.959 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000013725 
                 CD6 
                 −1.284 
                 5.043 
                 −4.557 
                 0.000 
                 0.002 
                 1.994 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000258539 
                 RP11- 
                 −0.748 
                 3.370 
                 −4.556 
                 0.000 
                 0.002 
                 2.006 
               
               
                   
                   
                 12J10.3 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000072818 
                 ACAP1 
                 −0.948 
                 6.160 
                 −4.562 
                 0.000 
                 0.002 
                 1.992 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000156381 
                 ANKRD9 
                 0.909 
                 5.074 
                 4.561 
                 0.000 
                 0.002 
                 2.015 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000165929 
                 TC2N 
                 −1.059 
                 6.055 
                 −4.573 
                 0.000 
                 0.002 
                 2.026 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000147526 
                 TACC1 
                 −0.599 
                 7.942 
                 −4.568 
                 0.000 
                 0.002 
                 1.997 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141934 
                 PLPP2 
                 1.283 
                 5.943 
                 4.575 
                 0.000 
                 0.002 
                 2.021 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000104814 
                 MAP4K1 
                 −1.165 
                 4.835 
                 −4.579 
                 0.000 
                 0.002 
                 2.059 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000113594 
                 LIFR 
                 −1.402 
                 5.977 
                 −4.580 
                 0.000 
                 0.002 
                 2.051 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000178307 
                 TMEM11 
                 0.592 
                 3.740 
                 4.577 
                 0.000 
                 0.002 
                 2.068 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000149115 
                 TNKS1BP1 
                 0.720 
                 8.232 
                 4.579 
                 0.000 
                 0.002 
                 2.027 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000115232 
                 ITGA4 
                 −1.084 
                 5.797 
                 −4.588 
                 0.000 
                 0.002 
                 2.075 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197044 
                 ZNF441 
                 −0.785 
                 4.020 
                 −4.584 
                 0.000 
                 0.002 
                 2.088 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138162 
                 TACC2 
                 0.848 
                 6.815 
                 4.600 
                 0.000 
                 0.002 
                 2.087 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000064012 
                 CASP8 
                 −0.707 
                 6.034 
                 −4.596 
                 0.000 
                 0.002 
                 2.105 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000050820 
                 BCAR1 
                 0.791 
                 6.294 
                 4.597 
                 0.000 
                 0.002 
                 2.108 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000117266 
                 CDK18 
                 0.936 
                 5.022 
                 4.602 
                 0.000 
                 0.002 
                 2.104 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116133 
                 DHCR24 
                 1.119 
                 7.294 
                 4.605 
                 0.000 
                 0.002 
                 2.097 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141298 
                 SSH2 
                 −0.603 
                 7.268 
                 −4.607 
                 0.000 
                 0.002 
                 2.114 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000181588 
                 MEX3D 
                 0.905 
                 4.514 
                 4.611 
                 0.000 
                 0.002 
                 2.154 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000123338 
                 NCKAP1L 
                 −0.829 
                 6.793 
                 −4.612 
                 0.000 
                 0.002 
                 2.139 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196405 
                 EVL 
                 −0.846 
                 7.403 
                 −4.614 
                 0.000 
                 0.002 
                 2.126 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000155016 
                 CYP2U1 
                 −0.807 
                 3.194 
                 −4.620 
                 0.000 
                 0.002 
                 2.186 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000076356 
                 PLXNA2 
                 0.895 
                 6.494 
                 4.639 
                 0.000 
                 0.002 
                 2.205 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000186350 
                 RXRA 
                 0.601 
                 7.402 
                 4.634 
                 0.000 
                 0.002 
                 2.200 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000006704 
                 GTF2IRD1 
                 0.828 
                 5.604 
                 4.641 
                 0.000 
                 0.002 
                 2.231 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000047634 
                 SCML1 
                 −0.779 
                 4.723 
                 −4.642 
                 0.000 
                 0.002 
                 2.254 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000169860 
                 P2RY1 
                 1.058 
                 4.446 
                 4.651 
                 0.000 
                 0.002 
                 2.258 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116641 
                 DOCK7 
                 0.733 
                 7.233 
                 4.648 
                 0.000 
                 0.002 
                 2.235 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000129474 
                 AJUBA 
                 0.976 
                 6.117 
                 4.663 
                 0.000 
                 0.002 
                 2.285 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000020256 
                 ZFP64 
                 0.592 
                 5.005 
                 4.660 
                 0.000 
                 0.002 
                 2.296 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116871 
                 MAP7D1 
                 0.758 
                 6.943 
                 4.664 
                 0.000 
                 0.002 
                 2.286 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000113263 
                 ITK 
                 −1.428 
                 6.134 
                 −4.669 
                 0.000 
                 0.002 
                 2.303 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116221 
                 MRPL37 
                 0.612 
                 5.272 
                 4.667 
                 0.000 
                 0.002 
                 2.321  
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000177542 
                 SLC25A22 
                 0.642 
                 5.057 
                 4.671 
                 0.000 
                 0.002 
                 2.326 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000149418 
                 ST14 
                 0.978 
                 6.340 
                 4.681 
                 0.000 
                 0.002 
                 2.335 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000243725 
                 TTC4 
                 0.650 
                 4 410 
                 4.678 
                 0.000 
                 0.001 
                 2.364 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100842 
                 EFS 
                 0.996 
                 4.926 
                 4.684 
                 0.000 
                 0.001 
                 2.364 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000131378 
                 RFTN1 
                 −0.861 
                 6.038 
                 −4.694 
                 0.000 
                 0.001 
                 2.393 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000135185 
                 TMEM243 
                 −0.783 
                 4.854 
                 −4.704 
                 0.000 
                 0.001 
                 2.438 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000135426 
                 TESPA1 
                 −1.681 
                 4.546 
                 −4.710 
                 0.000 
                 0.001 
                 2.443 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000006327 
                 TNFRSF12A 
                 1.230 
                 5.627 
                 4.715 
                 0.000 
                 0.001 
                 2.455 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111666 
                 CHPT1 
                 −0.836 
                 4.953 
                 −4.711 
                 0.000 
                 0.001 
                 2.458 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100300 
                 TSPO 
                 0.649 
                 5.203 
                 4.712 
                 0.000 
                 0.001 
                 2.460 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000183010 
                 PVCR1 
                 1.013 
                 4.258 
                 4.720 
                 0.000 
                 0.001 
                 2.473 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000123989 
                 CHPF 
                 0.869 
                 5.915 
                 4.720 
                 0.000 
                 0.001 
                 2.451 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000172336 
                 POP7 
                 0.692 
                 3.486 
                 4.719 
                 0.000 
                 0.001 
                 2.478 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000147457 
                 CHMP7 
                 −0.799 
                 6.007 
                 −4.726 
                 0.000 
                 0.001 
                 2.480 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000003147 
                 ICA1 
                 −0.942 
                 3.575 
                 −4.724 
                 0.000 
                 0.001 
                 2.490 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000141098 
                 GFOD2 
                 0.609 
                 5.815 
                 4.725 
                 0.000 
                 0.001 
                 2.490 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000164691 
                 TAGAP 
                 −1.312 
                 4.936 
                 −4.732 
                 0.000 
                 0.001 
                 2.507 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000080546 
                 SESN1 
                 −0.869 
                 5.205 
                 −4.728 
                 0.000 
                 0.001 
                 2.510 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000113712 
                 CSNK1A1 
                 0.604 
                 8.311 
                 4.733 
                 0.000 
                 0.001 
                 2.491 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000185963 
                 BICD2 
                 0.673 
                 7.499 
                 4.736 
                 0.000 
                 0.001 
                 2.502 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000137693 
                 YAP1 
                 0.636 
                 7.642 
                 4.742 
                 0.000 
                 0.001 
                 2.520 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000188229 
                 TUBB4B 
                 0.731 
                 7.150 
                 4.744 
                 0.000 
                 0.001 
                 2.526 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138767 
                 CNOT6L 
                 −0.848 
                 8.037 
                 −4.767 
                 0.000 
                 0.001 
                 2.584 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000168421 
                 RHOH 
                 −1.273 
                 5.625 
                 −4.769 
                 0.000 
                 0.001 
                 2.602 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111846 
                 GCNT2 
                 −0.862 
                 4.368 
                 −4.775 
                 0.000 
                 0.001 
                 2.643 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142949 
                 PTPRF 
                 0.918 
                 8.842 
                 4.781 
                 0.000 
                 0.001 
                 2.625 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000084636 
                 COL16A1 
                 1.024 
                 7.656 
                 4.790 
                 0.000 
                 0.001 
                 2.650 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000089775 
                 ZBTB25 
                 −0.679 
                 6.437 
                 −4.784 
                 0.000 
                 0.001 
                 2.661 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000117395 
                 EBNA1BP2 
                 0.707 
                 4.976 
                 4.785 
                 0.000 
                 0.001 
                 2.677 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000105355 
                 PLIN3 
                 0.794 
                 5.600 
                 4.788 
                 0.000 
                 0.001 
                 2.684 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000160753 
                 RUSC1 
                 0.898 
                 5.344 
                 4.792 
                 0.000 
                 0.001 
                 2.693 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000172270 
                 BSG 
                 0.654 
                 7.195 
                 4.792 
                 0.000 
                 0.001 
                 2.670 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000187627 
                 RGPD1 
                 −0.942 
                 4.324 
                 −4.808 
                 0.000 
                 0.001 
                 2.734 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000177674 
                 AGTRAP 
                 0.876 
                 4.846 
                 4.809 
                 0.000 
                 0.001 
                 2.747 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000176809 
                 LRRC37A3 
                 −0.618 
                 5.697 
                 −4.810 
                 0.000 
                 0.001 
                 2.742 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000238227 
                 C9orf69 
                 0.638 
                 5.606 
                 4.815 
                 0.000 
                 0.001 
                 2.759 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000066923 
                 STAG3 
                 −0.956 
                 6.143 
                 −4.823 
                 0.000 
                 0.001 
                 2.754 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000110104 
                 CCDC86 
                 0.938 
                 4.215 
                 4.821 
                 0.000 
                 0.001 
                 2.779 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000184588 
                 PDE4B 
                 −1.069 
                 5.742 
                 −4.826 
                 0.000 
                 0.001 
                 2.772 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116649 
                 SRM 
                 0.609 
                 5.237 
                 4.821 
                 0.000 
                 0.001 
                 2.777 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000170542 
                 SERPINB9 
                 −0.811 
                 6.327 
                 −4.827 
                 0.000 
                 0.001 
                 2.775 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196912 
                 ANKRD36B 
                 −0.654 
                 5.995 
                 −4.837 
                 0.000 
                 0.001 
                 2.822 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000108622 
                 ICAM2 
                 −0.844 
                 3.535 
                 −4.850 
                 0.000 
                 0.001 
                 2.858 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000120910 
                 PPP3CC 
                 −0.730 
                 4.548 
                 −4.850 
                 0.000 
                 0.001 
                 2.868 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000082781 
                 ITGB5 
                 1.036 
                 6.486 
                 4.858 
                 0.000 
                 0.001 
                 2.860 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000145743 
                 FBXL17 
                 −0.634 
                 5.245 
                 −4.853 
                 0.000 
                 0.001 
                 2.879 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000173890 
                 GPR160 
                 −0.852 
                 3.730 
                 −4.853 
                 0.000 
                 0.001 
                 2.877 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000034053 
                 APBA2 
                 −1.297 
                 4.603 
                 −4.863 
                 0.000 
                 0.001 
                 2.892 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000213923 
                 CSNK1E 
                 0.648 
                 7.333 
                 4.864 
                 0.000 
                 0.001 
                 2.886 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000130560 
                 UBAC1 
                 0.632 
                 5.079 
                 4.873 
                 0.000 
                 0.001 
                 2.937 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163935 
                 SFMBT1 
                 −0.629 
                 5.015 
                 −4.875 
                 0.000 
                 0.001 
                 2.943 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000188157 
                 AGRN 
                 1.001 
                 8.450 
                 4.882 
                 0.000 
                 0.001 
                 2.930 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000187824 
                 TMEM220 
                 −0.852 
                 3.219 
                 −4.877 
                 0.000 
                 0.001 
                 2.933 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000112182 
                 BACH2 
                 −1.443 
                 5.553 
                 −4.888 
                 0.000 
                 0.001 
                 2.955 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000054219 
                 LY75 
                 −1.062 
                 5.783 
                 −4.913 
                 0.000 
                 0.001 
                 3.031 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000005302 
                 MSL3 
                 −0.638 
                 5.615 
                 −4.914 
                 0.000 
                 0.001 
                 3.055 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000050327 
                 ARHGEF5 
                 0.808 
                 5.829 
                 4.916 
                 0.000 
                 0.001 
                 3.065 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000121210 
                 KIAA0922 
                 −0.850 
                 6.079 
                 −4.934 
                 0.000 
                 0.001 
                 3.106 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000119333 
                 WDR34 
                 0.815 
                 4.646 
                 4.941 
                 0.000 
                 0.001 
                 3.141 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000172349 
                 IL16 
                 −1.284 
                 6.119 
                 −4.948 
                 0.000 
                 0.001 
                 3.137 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000129911 
                 KLF16 
                 0.635 
                 5.389 
                 4.945 
                 0.000 
                 0.001 
                 3.153 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000102100 
                 SLC35A2 
                 0.586 
                 4.437 
                 4.953 
                 0.000 
                 0.001 
                 3.174 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000173114 
                 LRRN3 
                 −0.764 
                 3.598 
                 −4.958 
                 0.000 
                 0.001 
                 3.181 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000223547 
                 ZNF844 
                 −0.926 
                 4.732 
                 −4.966 
                 0.000 
                 0.001 
                 3.209 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000118596 
                 SLC16A7 
                 −0.956 
                 5.772 
                 −4.979 
                 0.000 
                 0.001 
                 3.231 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000132196 
                 HSD17B7 
                 −0.604 
                 4.321 
                 −4.976 
                 0.000 
                 0.001 
                 3.238 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000103365 
                 GGA2 
                 −0.704 
                 7.164 
                 −4.977 
                 0.000 
                 0.001 
                 3.234 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000105483 
                 CARD8 
                 −0.689 
                 6.511 
                 −4.979 
                 0.000 
                 0.001 
                 3.248 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162302 
                 RPS6KA4 
                 0.645 
                 6.029 
                 4.982 
                 0.000 
                 0.001 
                 3.262 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000006118 
                 TMEM132A 
                 1.234 
                 6.305 
                 4.995 
                 0.000 
                 0.001 
                 3.277 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000205730 
                 ITPRIPL2 
                 0.677 
                 7.227 
                 4.992 
                 0.000 
                 0.001 
                 3.279 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000153048 
                 CARHSP1 
                 0.804 
                 6.084 
                 4.999 
                 0.000 
                 0.001 
                 3.316 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000105866 
                 SP4 
                 −0.786 
                 5.031 
                 −5.017 
                 0.000 
                 0.001 
                 3.367 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116260 
                 QSOX1 
                 0.837 
                 6.954 
                 5.019 
                 0.000 
                 0.001 
                 3.361 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000179456 
                 ZBTB18 
                 −0.858 
                 4.841 
                 −5.020 
                 0.000 
                 0.001 
                 3.377 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000160113 
                 NR2F6 
                 0.946 
                 4.132 
                 5.022 
                 0.000 
                 0.001 
                 3.378 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167553 
                 TUBA1C 
                 0.856 
                 7.267 
                 5.039 
                 0.000 
                 0.001 
                 3.409 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000077044 
                 DGKD 
                 −0.768 
                 6.414 
                 −5.035 
                 0.000 
                 0.001 
                 3.413 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142684 
                 ZNF593 
                 0.756 
                 2.636 
                 5.039 
                 0.000 
                 0.001 
                 3.398 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000127080 
                 IPPK 
                 0.857 
                 5.884 
                 5.043 
                 0.000 
                 0.001 
                 3.442 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000037897 
                 METTL1 
                 0.769 
                 3.248 
                 5.050 
                 0.000 
                 0.001 
                 3.448 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000151348 
                 EXT2 
                 0.593 
                 6.172 
                 5.053 
                 0.000 
                 0.001 
                 3.474 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000179909 
                 ZNF154 
                 −0.671 
                 5.071 
                 −5.064 
                 0.000 
                 0.001 
                 3.508 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000188452 
                 CERKL 
                 −0.768 
                 3.996 
                 −5.068 
                 0.000 
                 0.001 
                 3.511 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000101596 
                 SMCHD1 
                 −0.733 
                 8.314 
                 −5.070 
                 0.000 
                 0.001 
                 3.514 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000168944 
                 CEP120 
                 −0.719 
                 5.476 
                 −5.071 
                 0.000 
                 0.001 
                 3.531 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163191 
                 S100A11 
                 0.927 
                 7.252 
                 5.081 
                 0.000 
                 0.001 
                 3.538 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000197217 
                 ENTPD4 
                 −0.587 
                 6.949 
                 −5.079 
                 0.000 
                 0.001 
                 3.543 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000171791 
                 BCL2 
                 −1.029 
                 6.515 
                 −5.097 
                 0.000 
                 0.001 
                 3.581 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198624 
                 CCDC69 
                 −0.790 
                 5.502 
                 −5.091 
                 0.000 
                 0.001 
                 3.590 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134324 
                 LPIN1 
                 −0.957 
                 6.846 
                 −5.104 
                 0.000 
                 0.001 
                 3.600 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000187239 
                 FNBP1 
                 −0.779 
                 6.844 
                 −5.103 
                 0.000 
                 0.001 
                 3.620 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000089094 
                 KDM2B 
                 −1.278 
                 6.492 
                 −5.120 
                 0.000 
                 0.001 
                 3.655 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000174013 
                 FBXO45 
                 0.790 
                 5.520 
                 5.137 
                 0.000 
                 0.001 
                 3.730 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000165209 
                 STRBP 
                 −0.874 
                 5.825 
                 −5.141 
                 0.000 
                 0.001 
                 3.735 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198932 
                 GPRASP1 
                 −1.047 
                 4.607 
                 −5.144 
                 0.000 
                 0.001 
                 3.736 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000168685 
                 IL7R 
                 −1.129 
                 7.463 
                 −5.148 
                 0.000 
                 0.001 
                 3.738 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000144749 
                 LRIG1 
                 −0.739 
                 5.807 
                 −5.154 
                 0.000 
                 0.001 
                 3.777 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000178585 
                 CTNNBIP1 
                 1.074 
                 5.442 
                 5.166 
                 0.000 
                 0.001 
                 3.801 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196459 
                 TRAPPC2 
                 −0.599 
                 5.062 
                 −5.175 
                 0.000 
                 0.001 
                 3.846 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000105708 
                 ZNF14 
                 −0.795 
                 3.238 
                 −5.176 
                 0.000 
                 0.001 
                 3.815 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000150995 
                 ITPR1 
                 −1.128 
                 6.573 
                 −5.199 
                 0.000 
                 0.001 
                 3.897 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196268 
                 ZNF493 
                 −0.637 
                 5.822 
                 −5.192 
                 0.000 
                 0.001 
                 3.895 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000110400 
                 NECTIN1 
                 1.230 
                 7.462 
                 5.199 
                 0.000 
                 0.001 
                 3.890 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000134954 
                 ETS1 
                 −0.815 
                 8.326 
                 −5.193 
                 0.000 
                 0.001 
                 3.888 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000095383 
                 TBC1D2 
                 1.038 
                 5.587 
                 5.213 
                 0.000 
                 0.001 
                 3.943 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000165804 
                 ZNF219 
                 0.666 
                 4.798 
                 5.210 
                 0.000 
                 0.001 
                 3.945 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000117643 
                 MANIC1 
                 −1.050 
                 4.603 
                 −5.219 
                 0.000 
                 0.001 
                 3.963 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163975 
                 MELTF 
                 0.911 
                 4.972 
                 5.221 
                 0.000 
                 0.001 
                 3.980 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000181722 
                 ZBTB20 
                 −0.799 
                 7.965 
                 −5.219 
                 0.000 
                 0.001 
                 3.971 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000077157 
                 PPP1R12B 
                 −0.706 
                 7.037 
                 −5.223 
                 0.000 
                 0.001 
                 3.984 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000065809 
                 FAM107B 
                 −1.126 
                 6.305 
                 −5.238 
                 0.000 
                 0.001 
                 4.016 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000142669 
                 SH3BGRL3 
                 0.635 
                 6.631 
                 5.238 
                 0.000 
                 0.001 
                 4.037 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000136026 
                 CKAP4 
                 0.956 
                 6.922 
                 5.247 
                 0.000 
                 0.001 
                 4.041 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000170677 
                 SOCS6 
                 0.841 
                 4.864 
                 5.241 
                 0.000 
                 0.001 
                 4.046 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000155085 
                 AK9 
                 −0.769 
                 3.484 
                 −5.244 
                 0.000 
                 0.001 
                 4.023 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000185803 
                 SLC52A2 
                 0.773 
                 5.077 
                 5.245 
                 0.000 
                 0.001 
                 4.056 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000188522 
                 FAM83G 
                 1.078 
                 6.451 
                 5.253 
                 0.000 
                 0.001 
                 4.062 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000136830 
                 FAM129B 
                 0.914 
                 7.815 
                 5.256 
                 0.000 
                 0.001 
                 4.071 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000139597 
                 N4BP2L1 
                 −0.775 
                 4.663 
                 −5.256 
                 0.000 
                 0.001 
                 4.081 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000214160 
                 ALG3 
                 0.591 
                 4.808 
                 5.270 
                 0.000 
                 0.001 
                 4.131 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000154814 
                 OXNAD1 
                 −0.930 
                 5.352 
                 −5.273 
                 0.000 
                 0.001 
                 4.139 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198382 
                 UVRAG 
                 −0.617 
                 5.794 
                 −5.272 
                 0.000 
                 0.001 
                 4.141 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000125245 
                 GPR18 
                 −0.797 
                 3.830 
                 −5.278 
                 0.000 
                 0.001 
                 4.127 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000010810 
                 FYN 
                 −0.855 
                 6.392 
                 −5.286 
                 0.000 
                 0.001 
                 4.176 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000112149 
                 CD83 
                 −1.227 
                 5.120 
                 −5.295 
                 0.000 
                 0.001 
                 4.191 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100304 
                 TTLL12 
                 0.784 
                 5.941 
                 5.291 
                 0.000 
                 0.001 
                 4.198 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000185697 
                 MYBL1 
                 −1.282 
                 3.984 
                 −5.304 
                 0.000 
                 0.001 
                 4.172 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100804 
                 PSMB5 
                 0.840 
                 5.277 
                 5.305 
                 0.000 
                 0.001 
                 4.228 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000182230 
                 FAM153B 
                 −1.295 
                 3.641 
                 −5.329 
                 0.000 
                 0.001 
                 4.264 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111860 
                 CEP85L 
                 −0.897 
                 5.181 
                 −5.326 
                 0.000 
                 0.001 
                 4.303 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000131653 
                 TRAF7 
                 0.617 
                 6.577 
                 5.337 
                 0.000 
                 0.001 
                 4.339 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000121966 
                 CXCR4 
                 −1.446 
                 6.918 
                 −5.351 
                 0.000 
                 0.001 
                 4.357 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000118482 
                 PHF3 
                 −0.611 
                 7.322 
                 −5.378 
                 0.000 
                 0.001 
                 4.460 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000082512 
                 TRAF5 
                 −0.904 
                 6.182 
                 −5.394 
                 0.000 
                 0.001 
                 4.511 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000116212 
                 LRRC42 
                 0.909 
                 4.193 
                 5.393 
                 0.000 
                 0.001 
                 4.481 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000081320 
                 STK17B 
                 −0.923 
                 7.868 
                 −5.408 
                 0.000 
                 0.001 
                 4.541 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000269404 
                 SPIB 
                 −1.375 
                 4.499 
                 −5.412 
                 0.000 
                 0.001 
                 4.545 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000157077 
                 ZFYVE9 
                 0.952 
                 5.526 
                 5.418 
                 0.000 
                 0.001 
                 4.581 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000132819 
                 RBM38 
                 −0.935 
                 5.325 
                 −5.455 
                 0.000 
                 0.000 
                 4.695 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000138795 
                 LEF1 
                 −1.398 
                 5.114 
                 −5.463 
                 0.000 
                 0.000 
                 4.696 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000173200 
                 PARP15 
                 −1.051 
                 7.023 
                 −5.483 
                 0.000 
                 0.000 
                 4.764 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000153885 
                 KCTD15 
                 0.862 
                 5.747 
                 5.488 
                 0.000 
                 0.000 
                 4.802 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000114491 
                 UMPS 
                 0.784 
                 5.786 
                 5.495 
                 0.000 
                 0.000 
                 4.825 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000188643 
                 S100A16 
                 1.114 
                 6.648 
                 5.510 
                 0.000 
                 0.000 
                 4.847 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000240849 
                 TMEM189 
                 0.730 
                 6.643 
                 5.505 
                 0.000 
                 0.000 
                 4.854 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000206053 
                 HN1L 
                 0.708 
                 6.640 
                 5.506 
                 0.000 
                 0.000 
                 4.860 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000224051 
                 CPTP 
                 0.677 
                 4.410 
                 5.539 
                 0.000 
                 0.000 
                 4.932 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000104660 
                 LEPROTL1 
                 −0.792 
                 5.703 
                 −5.551 
                 0.000 
                 0.000 
                 4.991 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000186854 
                 TRABD2A 
                 −1.446 
                 4.775 
                 −5.564 
                 0.000 
                 0.000 
                 4.988 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000118922 
                 KLF12 
                 −1.093 
                 6.090 
                 −5.565 
                 0.000 
                 0.000 
                 5.015 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000166025 
                 AMOTL1 
                 1.035 
                 7.486 
                 5.569 
                 0.000 
                 0.000 
                 5.029 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000157911 
                 PEX10 
                 0.685 
                 3.995 
                 5.567 
                 0.000 
                 0.000 
                 5.002 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000100139 
                 MICALL1 
                 1.006 
                 7.181 
                 5.576 
                 0.000 
                 0.000 
                 5.052 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167695 
                 FAM57A 
                 0.869 
                 4.784 
                 5.600 
                 0.000 
                 0.000 
                 5.132 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000159023 
                 EPB41 
                 −0.902 
                 6.816 
                 −5.627 
                 0.000 
                 0.000 
                 5.227 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167483 
                 FAM129C 
                 −1.416 
                 5.554 
                 −5.635 
                 0.000 
                 0.000 
                 5.226 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000182568 
                 SATB1 
                 −1.347 
                 6.057 
                 −5.662 
                 0.000 
                 0.000 
                 5.314 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000205268 
                 PDE7A 
                 −0.736 
                 7.026 
                 −5.654 
                 0.000 
                 0.000 
                 5.317 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000174485 
                 DENND4A 
                 −0.842 
                 6.688 
                 −5.685 
                 0.000 
                 0.000 
                 5.411 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000189337 
                 KAZN 
                 1.295 
                 5.006 
                 5.697 
                 0.000 
                 0.000 
                 5.413 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000133740 
                 E2F5 
                 −1.597 
                 4.656 
                 −5.702 
                 0.000 
                 0.000 
                 5.411 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000070731 
                 ST6GALNAC2 
                 0.996 
                 5.029 
                 5.695 
                 0.000 
                 0.000 
                 5.428 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000133639 
                 BTG1 
                 −0.962 
                 8.026 
                 −5.700 
                 0.000 
                 0.000 
                 5.446 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000152520 
                 PAN3 
                 −0.654 
                 6.651 
                 −5.707 
                 0.000 
                 0.000 
                 5.480 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198270 
                 TMEM116 
                 −0.970 
                 4.975 
                 −5.720 
                 0.000 
                 0.000 
                 5.497 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000160691 
                 SHC1 
                 0.631 
                 7.619 
                 5.731 
                 0.000 
                 0.000 
                 5.554 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000069493 
                 CLEC2D 
                 −1.155 
                 6.220 
                 −5.767 
                 0.000 
                 0.000 
                 5.636 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000169508 
                 GPR183 
                 −1.164 
                 5.105 
                 −5.789 
                 0.000 
                 0.000 
                 5.685 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000198625 
                 MDM4 
                 −0.715 
                 8.224 
                 −5.796 
                 0.000 
                 0.000 
                 5.758 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000163293 
                 NIPAL1 
                 1.391 
                 4.501 
                 5.831 
                 0.000 
                 0.000 
                 5.794 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000145241 
                 CENPC 
                 −0.663 
                 5.966 
                 −5.823 
                 0.000 
                 0.000 
                 5.837 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000177873 
                 ZNF619 
                 −0.786 
                 4.047 
                 −5.882 
                 0.000 
                 0.000 
                 5.937 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143321 
                 HDGF 
                 0.797 
                 7.794 
                 5.907 
                 0.000 
                 0.000 
                 6.104 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000162413 
                 KLHL21 
                 0.828 
                 6.699 
                 5.949 
                 0.000 
                 0.000 
                 6.233 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000158985 
                 CDC42SE2 
                 −0.960 
                 6.699 
                 −5.971 
                 0.000 
                 0.000 
                 6.296 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000169972 
                 PUSL1 
                 0.751 
                 3.307 
                 6.028 
                 0.000 
                 0.000 
                 6.366 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000143772 
                 ITPKB 
                 −0.844 
                 6.898 
                 −6.061 
                 0.000 
                 0.000 
                 6.581 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000166432 
                 ZMAT1 
                 −1.402 
                 4.478 
                 −6.088 
                 0.000 
                 0.000 
                 6.561 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000154217 
                 PITPNC1 
                 −0.831 
                 5.134 
                 −6.105 
                 0.000 
                 0.000 
                 6.678 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000196911 
                 KPNA5 
                 −0.672 
                 7.718 
                 −6.154 
                 0.000 
                 0.000 
                 6.874 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000149311 
                 ATM 
                 −0.980 
                 8.318 
                 −6.207 
                 0.000 
                 0.000 
                 7.032 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000111321 
                 LTBR 
                 0.773 
                 6.858 
                 6.338 
                 0.000 
                 0.000 
                 7.445 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000113441 
                 LNPEP 
                 −0.887 
                 8.260 
                 −6.342 
                 0.000 
                 0.000 
                 7.457 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000133872 
                 SARAF 
                 −0.771 
                 7.323 
                 −6.348 
                 0.000 
                 0.000 
                 7.477 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000169762 
                 TAPT1 
                 −0.786 
                 4.892 
                 −6.364 
                 0.000 
                 0.000 
                 7.459 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000114867 
                 EIF4G1 
                 0.607 
                 9.184 
                 6.399 
                 0.000 
                 0.000 
                 7.624 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000107404 
                 DVL1 
                 0.915 
                 6.014 
                 6.438 
                 0.000 
                 0.000 
                 7.734 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000104177 
                 MYEF2 
                 −1.210 
                 4.015 
                 −6.533 
                 0.000 
                 0.000 
                 7.953 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000117411 
                 B4GALT2 
                 1.040 
                 5.379 
                 6.698 
                 0.000 
                 0.000 
                 8.521 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000205189 
                 ZBTB10 
                 −1.170 
                 5.508 
                 −6.729 
                 0.000 
                 0.000 
                 8.623 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000101109 
                 STK4 
                 −0.867 
                 7.643 
                 −6.952 
                 0.000 
                 0.000 
                 9.349 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000103657 
                 HERC1 
                 −0.688 
                 7.923 
                 −7.062 
                 0.000 
                 0.000 
                 9.692 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000128000 
                 ZNF780B 
                 −0.755 
                 5.830 
                 −7.077 
                 0.000 
                 0.000 
                 9.698 
               
               
                 LNM Group 2 vs. Group 1 
                 ENSG00000167962 
                 ZNF598 
                 0.989 
                 5.911 
                 7.535 
                 0.000 
                 0.000 
                 11.077 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000140320 
                 BAHD1 
                 −0.696 
                 5.343 
                 −3.250 
                 0.002 
                 0.050 
                 −1.577 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000137474 
                 MYO7A 
                 0.990 
                 4.279 
                 3.254 
                 0.002 
                 0.050 
                 −1.485 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000151292 
                 CSNK1G3 
                 −0.720 
                 5.789 
                 −3.254 
                 0.002 
                 0.050 
                 −1.560 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000203747 
                 FCGR3A 
                 2.306 
                 5.467 
                 3.260 
                 0.002 
                 0.049 
                 −1.496 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000163686 
                 ABHD6 
                 0.879 
                 3.150 
                 3.256 
                 0.002 
                 0.049 
                 −1.472 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000110047 
                 EHD1 
                 0.756 
                 6.373 
                 3.259 
                 0.002 
                 0.049 
                 −1.572 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000108604 
                 SMARCD2 
                 −0.658 
                 6.178 
                 −3.257 
                 0.002 
                 0.049 
                 −1.573 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000138757 
                 G3BP2 
                 −0.694 
                 7.036 
                 −3.259 
                 0.002 
                 0.049 
                 −1.597 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000151748 
                 SAV1 
                 −0.835 
                 5.495 
                 −3.256 
                 0.002 
                 0.049 
                 −1.538 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000163131 
                 CTSS 
                 1.239 
                 6.658 
                 3.264 
                 0.002 
                 0.049 
                 −1.528 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000051523 
                 CYBA 
                 0.915 
                 6.100 
                 3.264 
                 0.002 
                 0.049 
                 −1.525 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000116871 
                 MAP7D1 
                 0.911 
                 6.943 
                 3.263 
                 0.002 
                 0.049 
                 −1.582 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000125166 
                 GOT2 
                 0.586 
                 6.083 
                 3.263 
                 0.002 
                 0.049 
                 −1.553 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000197608 
                 ZNF841 
                 0.887 
                 5.508 
                 3.266 
                 0.002 
                 0.049 
                 −1.531 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000117984 
                 CTSD 
                 1.009 
                 8.610 
                 3.272 
                 0.002 
                 0.049 
                 −1.570 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000166813 
                 KIF7 
                 −1.379 
                 3.863 
                 −3.274 
                 0.002 
                 0.049 
                 −1.479 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000131724 
                 ILI3RA1 
                 0.925 
                 6.731 
                 3.274 
                 0.002 
                 0.048 
                 −1.530 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000141644 
                 MBD1 
                 0.766 
                 6.316 
                 3.275 
                 0.002 
                 0.048 
                 −1.544 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000228570 
                 NUTM2E 
                 0.903 
                 2.282 
                 3.276 
                 0.002 
                 0.048 
                 −1.410 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000004777 
                 ARHGAP33 
                 −1.405 
                 4.471 
                 −3.279 
                 0.002 
                 0.048 
                 −1.477 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000111666 
                 CHPT1 
                 −0.988 
                 4.953 
                 −3.280 
                 0.002 
                 0.048 
                 −1.465 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000232388 
                 LINC00493 
                 −0.728 
                 3.589 
                 −3.281 
                 0.002 
                 0.048 
                 −1.413 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000179627 
                 ZBTB42 
                 −0.865 
                 3.343 
                 −3.284 
                 0.002 
                 0.048 
                 −1.402 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000146192 
                 FGD2 
                 1.348 
                 6.172 
                 3.291 
                 0.002 
                 0.048 
                 −1.456 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000110675 
                 ELMOD1 
                 1.282 
                 1.844 
                 3.288 
                 0.002 
                 0.048 
                 −1.379 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000054965 
                 FAM168A 
                 0.660 
                 6.732 
                 3.289 
                 0.002 
                 0.048 
                 −1.501 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000105372 
                 RPS19 
                 −0.777 
                 8.221 
                 −3.290 
                 0.002 
                 0.048 
                 −1.520 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000120549 
                 KIAA1217 
                 −0.926 
                 6.908 
                 −3.290 
                 0.002 
                 0.048 
                 −1.517 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000203880 
                 PCMTD2 
                 −0.627 
                 6.261 
                 −3.295 
                 0.002 
                 0.047 
                 −1.486 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000178726 
                 THBD 
                 1.537 
                 6.440 
                 3.300 
                 0.002 
                 0 047 
                 −1 405 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000136960 
                 ENPP2 
                 1.482 
                 4.829 
                 3.304 
                 0.002 
                 0.047 
                 −1.379 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000188641 
                 DPYD 
                 1.127 
                 6.028 
                 3.302 
                 0.002 
                 0.047 
                 −1.400 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000110719 
                 TCIRG1 
                 0.859 
                 6.715 
                 3.306 
                 0.002 
                 0.047 
                 −1.466 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000189403 
                 HMGB1 
                 −0.601 
                 7.914 
                 −3.303 
                 0.002 
                 0.047 
                 −1.491 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000116128 
                 BCL9 
                 −1.081 
                 4.976 
                 −3.305 
                 0.002 
                 0.047 
                 −1.418 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000070404 
                 FSTL3 
                 1.716 
                 5.126 
                 3.309 
                 0.002 
                 0.047 
                 −1.368 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000184497 
                 TMEM255B 
                 1.352 
                 3.912 
                 3.308 
                 0.002 
                 0.047 
                 −1.353 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000067704 
                 IARS2 
                 −0.731 
                 6.373 
                 −3.308 
                 0.002 
                 0.047 
                 −1.444 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000196329 
                 GIMAP5 
                 1.666 
                 5.025 
                 3.315 
                 0.002 
                 0.046 
                 −1.363 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000221995 
                 TIAF1 
                 0.688 
                 4.552 
                 3.313 
                 0.002 
                 0.046 
                 −1.353 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000182004 
                 SNRPE 
                 −0.906 
                 4.387 
                 −3.312 
                 0.002 
                 0.046 
                 −1.362 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000103066 
                 PLA2G15 
                 0.595 
                 4.434 
                 3.316 
                 0.002 
                 0.046 
                 −1.345 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000243244 
                 STON1 
                 −1.178 
                 5.027 
                 −3.319 
                 0.002 
                 0.046 
                 −1.373 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000141506 
                 PIK3R5 
                 1.618 
                 5.404 
                 3.321 
                 0.002 
                 0.046 
                 −1.360 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000124688 
                 MAD2L1BP 
                 −0.684 
                 3.675 
                 −3.318 
                 0.002 
                 0.046 
                 −1.334 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000149357 
                 LAMTOR1 
                 0.585 
                 5.545 
                 3.321 
                 0.002 
                 0.046 
                 −1.358 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000176463 
                 SLCO3A1 
                 −0.928 
                 5.862 
                 −3.322 
                 0.002 
                 0.046 
                 −1.426 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000164692 
                 COL1A2 
                 2.484 
                 10.783 
                 3.327 
                 0.002 
                 0.046 
                 −1.408 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000113721 
                 PDGFRB 
                 1.249 
                 7.338 
                 3.329 
                 0.002 
                 0.046 
                 −1.410 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000124766 
                 SOX4 
                 −1.224 
                 6.606 
                 −3.331 
                 0.002 
                 0.045 
                 −1.411 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000181830 
                 SLC35C1 
                 0.833 
                 4.744 
                 3.330 
                 0.002 
                 0.045 
                 −1.315 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000175727 
                 MLXIP 
                 0.874 
                 7.832 
                 3.331 
                 0.002 
                 0.045 
                 −1.418 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000198909 
                 MAP3K3 
                 0.747 
                 5.826 
                 3.333 
                 0.002 
                 0.045 
                 −1.372 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000115137 
                 DNAJC27 
                 −1.123 
                 3.926 
                 −3.335 
                 0.002 
                 0.045 
                 −1.292 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000169957 
                 ZNF768 
                 −0.719 
                 4.412 
                 −3.338 
                 0.002 
                 0.045 
                 −1.319 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000154133 
                 ROBO4 
                 1.300 
                 4.075 
                 3.344 
                 0.002 
                 0.045 
                 −1.268 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000134830 
                 C5AR2 
                 1.287 
                 4.874 
                 3.344 
                 0.002 
                 0.045 
                 −1.293 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000125827 
                 TMX4 
                 −0.781 
                 6.112 
                 −3.344 
                 0.002 
                 0.045 
                 −1.357 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000125652 
                 ALKBH7 
                 −0.901 
                 3.115 
                 −3.341 
                 0.002 
                 0.045 
                 −1.261 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000155893 
                 PXYLP1 
                 −0.992 
                 4.930 
                 −3.342 
                 0.002 
                 0.045 
                 −1.345 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000160691 
                 SHC1 
                 0.632 
                 7.619 
                 3.347 
                 0.002 
                 0.044 
                 −1.371 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000163125 
                 RPRD2 
                 −0.596 
                 6.520 
                 −3.347 
                 0.002 
                 0.044 
                 −1.361 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000170604 
                 IRF2BP1 
                 −0.759 
                 4.024 
                 −3.349 
                 0.002 
                 0.044 
                 −1.275 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000136636 
                 KCTD3 
                 −0.861 
                 6.019 
                 −3.347 
                 0.002 
                 0.044 
                 −1.348 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000124440 
                 HIF3A 
                 −1.490 
                 4.340 
                 −3.350 
                 0.002 
                 0.044 
                 −1.283 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000163513 
                 TGFBR2 
                 1.017 
                 7.259 
                 3.352 
                 0.002 
                 0.044 
                 −1.334 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000162377 
                 COA7 
                 0.843 
                 5.401 
                 3.353 
                 0.002 
                 0.044 
                 −1.306 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000204070 
                 SYS1 
                 0.593 
                 5.270 
                 3.355 
                 0.002 
                 0.044 
                 −1.300 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000069275 
                 NUCKS1 
                 −0.885 
                 8.703 
                 −3.357 
                 0.002 
                 0.044 
                 −1.332 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000138080 
                 EMILIN1 
                 1.533 
                 5.519 
                 3.361 
                 0.002 
                 0.044 
                 −1.271 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000138641 
                 HERC3 
                 0.886 
                 6.303 
                 3.360 
                 0.002 
                 0.044 
                 −1.294 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000216937 
                 CCDC7 
                 −1.182 
                 3.695 
                 −3.362 
                 0.002 
                 0.044 
                 −1.210 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000187474 
                 FPR3 
                 1.319 
                 4.801 
                 3.367 
                 0.002 
                 0.043 
                 −1.220 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000059377 
                 TBXAS1 
                 0.916 
                 4.305 
                 3.366 
                 0.002 
                 0.043 
                 −1.210 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000110931 
                 CAMKK2 
                 0.639 
                 6.140 
                 3.364 
                 0.002 
                 0.043 
                 −1.316 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000063601 
                 MTMR1 
                 −0.647 
                 6.308 
                 −3.366 
                 0.002 
                 0.043 
                 −1.309 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000138119 
                 MYOF 
                 1.021 
                 7.897 
                 3.371 
                 0.002 
                 0.043 
                 −1.313 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000257093 
                 KIAA1147 
                 −0.784 
                 6.997 
                 −3.372 
                 0.002 
                 0.043 
                 −1.311 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000182899 
                 RPL35A 
                 −0.864 
                 7.557 
                 −3.371 
                 0.002 
                 0.043 
                 −1.315 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000159403 
                 C1R 
                 1.047 
                 7.164 
                 3.375 
                 0.002 
                 0.043 
                 −1.268 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000116199 
                 FAM2OB 
                 −0.812 
                 6.664 
                 −3.374 
                 0.002 
                 0.043 
                 −1.297 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000168542 
                 COL3A1 
                 2.204 
                 11.045 
                 3.379 
                 0.002 
                 0.043 
                 −1.276 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000145990 
                 GFOD1 
                 0.986 
                 6.415 
                 3.377 
                 0.002 
                 0.043 
                 −1.251 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000078237 
                 TIGAR 
                 1.712 
                 4.361 
                 3.383 
                 0.002 
                 0.043 
                 −1.185 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000078070 
                 MCCC1 
                 −0.867 
                 5.043 
                 −3.382 
                 0.002 
                 0.043 
                 −1.240 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000112149 
                 CD83 
                 −1.334 
                 5.120 
                 −3.383 
                 0.002 
                 0.043 
                 −1.249 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000112541 
                 PDE10A 
                 −1.442 
                 3.825 
                 −3.385 
                 0.002 
                 0.043 
                 −1.182 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000164684 
                 ZNF704 
                 −1.652 
                 5.657 
                 −3.386 
                 0.002 
                 0.043 
                 −1.247 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000102871 
                 TRADD 
                 0.696 
                 4.713 
                 3.386 
                 0.002 
                 0.042 
                 −1.171 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000113742 
                 CPEB4 
                 1.134 
                 6.574 
                 3.390 
                 0.002 
                 0.042 
                 −1.210 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000159733 
                 ZFYVE28 
                 1.193 
                 3.826 
                 3.390 
                 0.002 
                 0.042 
                 −1.140 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000259207 
                 ITGB3 
                 1.985 
                 3.076 
                 3.397 
                 0.002 
                 0.042 
                 −1.122 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000139629 
                 GALNT6 
                 1.699 
                 5.858 
                 3.400 
                 0.002 
                 0.042 
                 −1.191 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000162769 
                 FLVCR1 
                 −0.854 
                 5.445 
                 −3.398 
                 0.002 
                 0.042 
                 −1.187 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000135338 
                 LCA5 
                 −0.959 
                 2.683 
                 −3.397 
                 0.002 
                 0.042 
                 −1.150 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000118298 
                 CA14 
                 −1.078 
                 2.553 
                 −3.399 
                 0.001 
                 0.042 
                 −1.112 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000007237 
                 GAS7 
                 1.337 
                 5.701 
                 3.406 
                 0.001 
                 0.041 
                 −1.168 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000147905 
                 ZCCHC7 
                 −0.595 
                 5.368 
                 −3.404 
                 0.001 
                 0.041 
                 −1.191 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000114988 
                 LMAN2L 
                 −0.826 
                 3.777 
                 −3.406 
                 0.001 
                 0.041 
                 −1.110 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000144445 
                 KANSL1L 
                 −0.593 
                 5.622 
                 −3.409 
                 0.001 
                 0.041 
                 −1.172 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000111711 
                 GOLT1B 
                 0.885 
                 5.773 
                 3.412 
                 0.001 
                 0.041 
                 −1.149 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000165512 
                 ZNF22 
                 −0.731 
                 4.449 
                 −3.412 
                 0.001 
                 0.041 
                 −1.125 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000196912 
                 ANKRD36B 
                 −0.788 
                 5.995 
                 −3.413 
                 0.001 
                 0.041 
                 −1.171 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000204287 
                 HLA-DRA 
                 1.148 
                 8.392 
                 3.421 
                 0.001 
                 0.041 
                 −1.174 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000033327 
                 GAB2 
                 1.234 
                 5.449 
                 3.424 
                 0.001 
                 0.041 
                 −1.104 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000118369 
                 USP35 
                 1.266 
                 4.301 
                 3.424 
                 0.001 
                 0.041 
                 −1.069 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000088682 
                 COQ9 
                 0.797 
                 4.454 
                 3.423 
                 0.001 
                 0.041 
                 −1.070 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000146197 
                 SCUBE3 
                 −0.662 
                 4.473 
                 −3.424 
                 0.001 
                 0.041 
                 −1.145 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000056277 
                 ZNF280C 
                 −0.759 
                 4.238 
                 −3.424 
                 0.001 
                 0.041 
                 −1.072 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000129538 
                 RNASE1 
                 2.520 
                 4.986 
                 3.431 
                 0.001 
                 0.040 
                 −1.046 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000205423 
                 CNEP1R1 
                 0.637 
                 4.539 
                 3.428 
                 0.001 
                 0.040 
                 −1.063 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000166503 
                 RP11- 
                 −0.916 
                 6.556 
                 −3.431 
                 0.001 
                 0.040 
                 −1.149 
               
               
                   
                   
                 382A20.3 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000128228 
                 SDF2L1 
                 0.962 
                 3.008 
                 3.434 
                 0.001 
                 0.040 
                 −1.026 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000174669 
                 SLC29A2 
                 −1.331 
                 3.120 
                 −3.438 
                 0.001 
                 0.040 
                 −1.042 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000112992 
                 NNT 
                 −0.671 
                 6.532 
                 −3.439 
                 0.001 
                 0.040 
                 −1.120 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000175155 
                 YPEL2 
                 0.914 
                 5.977 
                 3.445 
                 0.001 
                 0.039 
                 −1.068 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000162885 
                 B3GALNT2 
                 −0.655 
                 5.346 
                 −3.446 
                 0.001 
                 0.039 
                 −1.082 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000074696 
                 HACD3 
                 −0.713 
                 6.575 
                 −3.445 
                 0.001 
                 0.039 
                 −1.113 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000103222 
                 ABCC1 
                 −0.671 
                 7.732 
                 −3.448 
                 0.001 
                 0.039 
                 −1.114 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000197044 
                 ZNF441 
                 −1.006 
                 4.020 
                 −3.451 
                 0.001 
                 0.039 
                 −1.001 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000001167 
                 NFYA 
                 −0.699 
                 5.384 
                 −3.453 
                 0.001 
                 0.039 
                 −1.061 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000121068 
                 TBX2 
                 1.866 
                 3.947 
                 3.458 
                 0.001 
                 0.039 
                 −0.991 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000031081 
                 ARHGAP31 
                 0.871 
                 6.390 
                 3.455 
                 0.001 
                 0.039 
                 −1.079 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000170004 
                 CHD3 
                 −0.867 
                 8.232 
                 −3.460 
                 0.001 
                 0.038 
                 −1.073 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000179456 
                 ZBTB18 
                 −1.003 
                 4.841 
                 −3.462 
                 0.001 
                 0.038 
                 −1.017 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000010327 
                 STAB1 
                 1.437 
                 7.455 
                 3.466 
                 0.001 
                 0.038 
                 −1.055 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000004399 
                 PLXND1 
                 0.779 
                 7.289 
                 3.465 
                 0.001 
                 0.038 
                 −1.065 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000138175 
                 ARL3 
                 −0.728 
                 3.153 
                 −3.465 
                 0.001 
                 0.038 
                 −0.954 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000185989 
                 RASA3 
                 1.081 
                 5.993 
                 3.469 
                 0.001 
                 0.038 
                 −1.005 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000111424 
                 VDR 
                 0.989 
                 5.716 
                 3.470 
                 0.001 
                 0.038 
                 −0.983 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000100284 
                 TOM1 
                 0.792 
                 5.827 
                 3.468 
                 0.001 
                 0.038 
                 −1.000 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000078043 
                 PIAS2 
                 −0.725 
                 6.289 
                 −3.468 
                 0.001 
                 0.038 
                 −1.043 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000109099 
                 PMP22 
                 1.621 
                 5.421 
                 3.479 
                 0.001 
                 0.037 
                 −0.973 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000176845 
                 METRNL 
                 1.219 
                 5.430 
                 3.478 
                 0.001 
                 0.037 
                 −0.981 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000110442 
                 COMMD9 
                 0.712 
                 4.764 
                 3.477 
                 0.001 
                 0.037 
                 −0.960 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000166946 
                 CCNDBP1 
                 0.746 
                 5.713 
                 3.479 
                 0.001 
                 0.037 
                 −0.966 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000125843 
                 AP5S1 
                 −0.911 
                 5.039 
                 −3.483 
                 0.001 
                 0.037 
                 −0.973 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000171115 
                 GIMAP8 
                 1.210 
                 4.344 
                 3.486 
                 0.001 
                 0.037 
                 −0.906 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000169403 
                 PTAFR 
                 1.031 
                 4.914 
                 3.489 
                 0.001 
                 0.037 
                 −0.905 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000187607 
                 ZNF286A 
                 −0.901 
                 4.927 
                 −3.490 
                 0.001 
                 0.037 
                 −0.955 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000107779 
                 BMPR1A 
                 −0.716 
                 5.699 
                 −3.492 
                 0.001 
                 0.037 
                 −0.950 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000196743 
                 GM2A 
                 1.103 
                 7.342 
                 3.499 
                 0.001 
                 0.036 
                 −0.945 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000119711 
                 ALDH6A1 
                 −0.679 
                 5.178 
                 −3.498 
                 0.001 
                 0.036 
                 −0.915 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000126217 
                 MCF2L 
                 −1.412 
                 5.564 
                 −3.499 
                 0.001 
                 0.036 
                 −0.949 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000168404 
                 MLKL 
                 1.035 
                 5.151 
                 3.503 
                 0.001 
                 0.036 
                 −0.881 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000131100 
                 ATP6V1E1 
                 0.595 
                 5.617 
                 3.502 
                 0.001 
                 0.036 
                 −0.923 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000086619 
                 ERO1B 
                 −0.881 
                 4.742 
                 −3.501 
                 0.001 
                 0.036 
                 −0.902 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000168758 
                 SEMA4C 
                 −0.897 
                 6.018 
                 −3.502 
                 0.001 
                 0.036 
                 −0.952 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000205363 
                 C150rf59 
                 −2.208 
                 3.251 
                 −3.514 
                 0.001 
                 0.035 
                 −0.842 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000160796 
                 NBEAL2 
                 0.866 
                 7.603 
                 3.516 
                 0.001 
                 0.035 
                 −0.928 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000112144 
                 ICK 
                 −0.824 
                 5.453 
                 −3.517 
                 0.001 
                 0.035 
                 −0.897 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000141384 
                 TAF4B 
                 −0.803 
                 4.539 
                 −3.527 
                 0.001 
                 0.034 
                 −0.858 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000115523 
                 GNLY 
                 1.725 
                 3.611 
                 3.534 
                 0.001 
                 0.034 
                 −0.783 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000177954 
                 RPS27 
                 −1.094 
                 7.559 
                 −3.534 
                 0.001 
                 0.034 
                 −0.888 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000144591 
                 GMPPA 
                 0.706 
                 4.906 
                 3.535 
                 0.001 
                 0.034 
                 −0.805 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000169744 
                 LDB2 
                 1.359 
                 3.759 
                 3.540 
                 0.001 
                 0.033 
                 −0.764 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000174600 
                 CMKLR1 
                 1.587 
                 4.770 
                 3.546 
                 0.001 
                 0.033 
                 −0.759 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000164733 
                 CTSB 
                 1.111 
                 9.580 
                 3.548 
                 0.001 
                 0.033 
                 −0.835 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000167635 
                 ZNF146 
                 −0.604 
                 6.698 
                 −3.543 
                 0.001 
                 0.033 
                 −0.854 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000123607 
                 TTC21B 
                 −0.664 
                 5.188 
                 −3.545 
                 0.001 
                 0.033 
                 −0.824 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000066651 
                 TRMT11 
                 −0.722 
                 3.866 
                 −3.543 
                 0.001 
                 0.033 
                 −0.772 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000106333 
                 PCOLCE 
                 1.902 
                 5.110 
                 3.558 
                 0.001 
                 0.033 
                 −0.737 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000145022 
                 TCTA 
                 0.820 
                 4.121 
                 3.552 
                 0.001 
                 0.033 
                 −0.742 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000103248 
                 MTHFSD 
                 0.698 
                 4.540 
                 3.552 
                 0.001 
                 0.033 
                 −0.751 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000050344 
                 NFE2L3 
                 −0.700 
                 6.014 
                 −3.553 
                 0.001 
                 0.033 
                 −0.820 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000109654 
                 TRIM2 
                 −1.146 
                 5.906 
                 −3.555 
                 0.001 
                 0.033 
                 −0.821 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000099998 
                 GGT5 
                 1.554 
                 5.447 
                 3.560 
                 0.001 
                 0.033 
                 −0.740 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000160255 
                 ITGB2 
                 1.300 
                 6.600 
                 3.561 
                 0.001 
                 0.033 
                 −0.780 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000107819 
                 SFXN3 
                 1.029 
                 5.841 
                 3.557 
                 0.001 
                 0.033 
                 −0.753 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000204592 
                 HLA-E 
                 0.801 
                 9.225 
                 3.559 
                 0.001 
                 0.033 
                 −0.819 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000151689 
                 INPP1 
                 0.993 
                 3.938 
                 3.561 
                 0.001 
                 0.033 
                 −0.724 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000070759 
                 TESK2 
                 −0.782 
                 3.250 
                 −3.563 
                 0.001 
                 0.032 
                 −0.707 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000010017 
                 RANBP9 
                 −0.620 
                 6.133 
                 −3.566 
                 0.001 
                 0.032 
                 −0.769 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000083720 
                 OXCT1 
                 −1.080 
                 5.273 
                 −3.566 
                 0.001 
                 0.032 
                 −0.727 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000159128 
                 IFNGR2 
                 0.808 
                 5.982 
                 3.570 
                 0.001 
                 0.032 
                 −0.759 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000156531 
                 PHF6 
                 −0.590 
                 5.965 
                 −3.570 
                 0.001 
                 0.032 
                 −0.762 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000114796 
                 KLHL24 
                 −0.788 
                 7.292 
                 −3.571 
                 0.001 
                 0.032 
                 −0.788 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000100036 
                 SLC35E4 
                 1.050 
                 2.833 
                 3.573 
                 0.001 
                 0.032 
                 −0.677 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000105738 
                 SIPA1L3 
                 −0.793 
                 7.401 
                 −3.573 
                 0.001 
                 0.032 
                 −0.778 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000103335 
                 PIEZO1 
                 0.841 
                 8.317 
                 3.576 
                 0.001 
                 0.032 
                 −0.777 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000128052 
                 KDR 
                 1.410 
                 4.276 
                 3.584 
                 0.001 
                 0.032 
                 −0.677 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000025708 
                 TYMP 
                 1.152 
                 7.828 
                 3.586 
                 0.001 
                 0.032 
                 −0.740 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000153187 
                 HNRNPU 
                 −0.623 
                 9.521 
                 −3.580 
                 0.001 
                 0.032 
                 −0.746 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000101236 
                 RNF24 
                 −0.728 
                 5.965 
                 −3.579 
                 0.001 
                 0.032 
                 −0.742 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000132196 
                 HSD17B7 
                 −0.739 
                 4.321 
                 −3.579 
                 0.001 
                 0.032 
                 −0.679 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000266074 
                 BAHCC1 
                 −1.497 
                 5.591 
                 −3.582 
                 0.001 
                 0.032 
                 −0.735 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000143149 
                 ALDH9A1 
                 −0.810 
                 5.481 
                 −3.596 
                 0.001 
                 0.031 
                 −0.670 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000241839 
                 PLEKHO2 
                 0.832 
                 5.640 
                 3.598 
                 0.001 
                 0.031 
                 −0.663 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000082805 
                 ERC1 
                 0.601 
                 7.227 
                 3.599 
                 0.001 
                 0.031 
                 −0.715 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000079215 
                 SLC1A3 
                 1.654 
                 5.467 
                 3.607 
                 0.001 
                 0.031 
                 −0.622 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000173442 
                 EHBP1L1 
                 0.799 
                 7.917 
                 3.604 
                 0.001 
                 0.031 
                 −0.697 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000119669 
                 IRF2BPL 
                 −0.666 
                 5.943 
                 −3.609 
                 0.001 
                 0.030 
                 −0.649 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000178163 
                 ZNF518B 
                 −0.949 
                 5.931 
                 −3.610 
                 0.001 
                 0.030 
                 −0.665 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000130489 
                 SCO2 
                 1.585 
                 4.765 
                 3.616 
                 0.001 
                 0.030 
                 −0.595 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000134470 
                 IL15RA 
                 1.086 
                 3.674 
                 3.612 
                 0.001 
                 0.030 
                 −0.579 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000152382 
                 TADA1 
                 −0.739 
                 3.995 
                 −3.617 
                 0.001 
                 0.030 
                 −0.583 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000171045 
                 TSNARE1 
                 −0.800 
                 4.465 
                 −3.621 
                 0.001 
                 0.030 
                 −0.593 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000131018 
                 SYNE1 
                 1.035 
                 7.671 
                 3.626 
                 0.001 
                 0.030 
                 −0.633 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000162511 
                 LAPTM5 
                 1.280 
                 7.971 
                 3.636 
                 0.001 
                 0.029 
                 −0.604 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000146070 
                 PLA2G7 
                 1.398 
                 3.797 
                 3.637 
                 0.001 
                 0.029 
                 −0.518 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000196126 
                 HLA-DRB1 
                 1.310 
                 7.074 
                 3.643 
                 0.001 
                 0.029 
                 −0.562 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000095139 
                 ARCN1 
                 0.595 
                 7.074 
                 3.640 
                 0.001 
                 0.029 
                 −0.589 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000116957 
                 TBCE 
                 −0.606 
                 4.423 
                 −3.642 
                 0.001 
                 0.029 
                 −0.527 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000160111 
                 CPAMD8 
                 −1.192 
                 4.049 
                 −3.648 
                 0.001 
                 0.028 
                 −0.500 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000019144 
                 PHLDB1 
                 1.101 
                 7.590 
                 3.654 
                 0.001 
                 0.028 
                 −0.566 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000023572 
                 GLRX2 
                 0.971 
                 1.996 
                 3.651 
                 0.001 
                 0.028 
                 −0.474 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000105866 
                 SP4 
                 −0.972 
                 5.031 
                 −3.651 
                 0.001 
                 0.028 
                 −0.515 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000177628 
                 GBA 
                 0.798 
                 4.994 
                 3.656 
                 0.001 
                 0.028 
                 −0.484 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000153786 
                 ZDHHC7 
                 0.620 
                 6.114 
                 3.657 
                 0.001 
                 0.028 
                 −0.510 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000140391 
                 TSPAN3 
                 −0.754 
                 6.447 
                 −3.659 
                 0.001 
                 0.028 
                 −0.540 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000155592 
                 ZKSCAN2 
                 −0.817 
                 3.578 
                 −3.664 
                 0.001 
                 0.028 
                 −0.447 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000177575 
                 CD163 
                 1.968 
                 6.905 
                 3.670 
                 0.001 
                 0.027 
                 −0.473 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000131165 
                 CHMP1A 
                 0.693 
                 6.033 
                 3.674 
                 0.001 
                 0.027 
                 −0.461 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000107738 
                 C100rf54 
                 1.217 
                 6.132 
                 3.678 
                 0.001 
                 0.027 
                 −0.449 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000161921 
                 CXCL16 
                 1.121 
                 5.517 
                 3.677 
                 0.001 
                 0.027 
                 −0.443 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000080298 
                 RFX3 
                 −0.861 
                 5.079 
                 −3.676 
                 0.001 
                 0.027 
                 −0.459 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000144857 
                 BOC 
                 −1.922 
                 4.934 
                 −3.683 
                 0.001 
                 0.027 
                 −0.436 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000184232 
                 OAF 
                 1.066 
                 4.375 
                 3.687 
                 0.001 
                 0.026 
                 −0.402 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000128000 
                 ZNF780B 
                 −0.671 
                 5.830 
                 −3.689 
                 0.001 
                 0.026 
                 −0.445 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000116962 
                 NID1 
                 −1.540 
                 6.963 
                 −3.698 
                 0.001 
                 0.026 
                 −0.438 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000069974 
                 RAB27A 
                 0.759 
                 5.335 
                 3.703 
                 0.001 
                 0.025 
                 −0.373 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000184470 
                 TXNRD2 
                 0.742 
                 4.944 
                 3.704 
                 0.001 
                 0.025 
                 −0.371 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000143842 
                 SOX13 
                 −0.988 
                 5.384 
                 −3.707 
                 0.001 
                 0.025 
                 −0.388 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000182578 
                 CSF1R 
                 1.148 
                 6.325 
                 3.710 
                 0.001 
                 0.025 
                 −0.377 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000110619 
                 CARS 
                 0.613 
                 6.508 
                 3.709 
                 0.001 
                 0.025 
                 −0.414 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000143379 
                 SETDB1 
                 −0.588 
                 6.028 
                 −3.709 
                 0.001 
                 0.025 
                 −0.390 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000101004 
                 NINL 
                 −1.243 
                 4.878 
                 −3.715 
                 0.001 
                 0.025 
                 −0.349 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000176014 
                 TUBB6 
                 1.299 
                 6.420 
                 3.732 
                 0.001 
                 0.024 
                 −0.331 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000177311 
                 ZBTB38 
                 0.768 
                 7.309 
                 3.726 
                 0.001 
                 0.024 
                 −0.363 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000101290 
                 CDS2 
                 −0.606 
                 6.874 
                 −3.732 
                 0.001 
                 0.024 
                 −0.344 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000079462 
                 PAFAH1B3 
                 −1.104 
                 2.958 
                 −3.729 
                 0.001 
                 0.024 
                 −0.275 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000105202 
                 FBL 
                 −1.154 
                 6.110 
                 −3.729 
                 0.001 
                 0.024 
                 −0.354 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000244274 
                 DBNDD2 
                 1.059 
                 4.028 
                 3.753 
                 0.001 
                 0.023 
                 −0.211 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000165997 
                 ARL5B 
                 −0.887 
                 6.324 
                 −3.753 
                 0.001 
                 0.023 
                 −0.274 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000174606 
                 ANGEL2 
                 −0.605 
                 6.051 
                 −3.758 
                 0.001 
                 0.023 
                 −0.256 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000150764 
                 DIXDC1 
                 1.764 
                 4.325 
                 3.766 
                 0.001 
                 0.023 
                 −0.187 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000126107 
                 HECTD3 
                 0.740 
                 5.308 
                 3.764 
                 0.001 
                 0.023 
                 −0.204 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000140948 
                 ZCCHC14 
                 0.815 
                 6.196 
                 3.767 
                 0.001 
                 0.022 
                 −0.235 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000166741 
                 NNMT 
                 2.171 
                 5.332 
                 3.776 
                 0.001 
                 0.022 
                 −0.172 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000101439 
                 CST3 
                 1.166 
                 6.765 
                 3.776 
                 0.001 
                 0.022 
                 −0.204 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000121281 
                 ADCY7 
                 1.031 
                 6.971 
                 3.772 
                 0.001 
                 0.022 
                 −0.223 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000168010 
                 ATG16L2 
                 0.906 
                 6.296 
                 3.771 
                 0.001 
                 0.022 
                 −0.209 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000143258 
                 USP21 
                 −0.708 
                 4.629 
                 −3.769 
                 0.001 
                 0.022 
                 −0.190 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000172037 
                 LAMB2 
                 1.219 
                 6.653 
                 3.781 
                 0.000 
                 0.022 
                 −0.195 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000167515 
                 TRAPPC2L 
                 0.859 
                 3.830 
                 3.780 
                 0.000 
                 0.022 
                 −0.140 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000198945 
                 L3MBTL3 
                 −1.167 
                 4.120 
                 −3.780 
                 0.000 
                 0.022 
                 −0.159 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000163866 
                 SMIM12 
                 0.775 
                 5.540 
                 3.785 
                 0.000 
                 0.022 
                 −0.163 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000158711 
                 ELK4 
                 −0.651 
                 8.230 
                 −3.787 
                 0.000 
                 0.022 
                 −0.201 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000186174 
                 BCL9L 
                 0.590 
                 7.473 
                 3.804 
                 0.000 
                 0.021 
                 −0.158 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000164638 
                 SLC29A4 
                 −1.932 
                 4.079 
                 −3.809 
                 0.000 
                 0.021 
                 −0.092 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000166454 
                 ATMIN 
                 0.861 
                 6.131 
                 3.813 
                 0.000 
                 0.021 
                 −0.097 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000233276 
                 GPX1 
                 0.789 
                 6.163 
                 3.816 
                 0.000 
                 0.021 
                 −0.085 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000150347 
                 ARID5B 
                 −0.895 
                 7.587 
                 −3.813 
                 0.000 
                 0.021 
                 −0.132 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000143013 
                 LMO4 
                 −1.126 
                 5.581 
                 −3.815 
                 0.000 
                 0.021 
                 −0.108 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000171843 
                 MLLT3 
                 −1.180 
                 4.755 
                 −3.813 
                 0.000 
                 0.021 
                 −0.084 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000127329 
                 PTPRB 
                 1.263 
                 5.478 
                 3.823 
                 0.000 
                 0.021 
                 −0.065 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000173011 
                 TADA2B 
                 0.782 
                 5.005 
                 3.820 
                 0.000 
                 0.021 
                 −0.049 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000143742 
                 SRP9 
                 −0.685 
                 7.103 
                 −3.821 
                 0.000 
                 0.021 
                 −0.108 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000141480 
                 ARRB2 
                 0.957 
                 5.844 
                 3.831 
                 0.000 
                 0.020 
                 −0.041 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000128567 
                 PODXL 
                 −1.378 
                 6.146 
                 −3.837 
                 0.000 
                 0.020 
                 −0.060 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000130766 
                 SESN2 
                 0.928 
                 4.154 
                 3.841 
                 0.000 
                 0.020 
                 0.014 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000163568 
                 AIM2 
                 1.578 
                 3.740 
                 3.846 
                 0.000 
                 0.020 
                 0.030 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000146376 
                 ARHGAP18 
                 1.051 
                 5.226 
                 3.846 
                 0.000 
                 0.020 
                 0.023 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000204186 
                 ZDBF2 
                 −1.004 
                 5.053 
                 −3.847 
                 0.000 
                 0.020 
                 −0.001 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000150687 
                 PRSS23 
                 1.637 
                 6.678 
                 3.858 
                 0.000 
                 0.019 
                 0.020 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000215251 
                 FASTKD5 
                 −0.634 
                 4.543 
                 −3.855 
                 0.000 
                 0.019 
                 0.038 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000198838 
                 RYR3 
                 −2.452 
                 5.479 
                 −3.861 
                 0.000 
                 0.019 
                 0.032 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000143815 
                 LBR 
                 −0.807 
                 6.569 
                 −3.861 
                 0.000 
                 0.019 
                 0.004 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000159164 
                 SV2A 
                 −1.221 
                 2.810 
                 −3.861 
                 0.000 
                 0.019 
                 0.073 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000153071 
                 DAB2 
                 1.320 
                 6.322 
                 3.878 
                 0.000 
                 0.019 
                 0.068 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000129250 
                 KIF1C 
                 0.994 
                 7.432 
                 3.874 
                 0.000 
                 0.019 
                 0.040 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000196189 
                 SEMA4A 
                 −1.214 
                 5.880 
                 −3.878 
                 0.000 
                 0.019 
                 0.057 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000100280 
                 AP1B1 
                 0.659 
                 7.158 
                 3.882 
                 0.000 
                 0.018 
                 0.061 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000182150 
                 ERCC6L2 
                 −0.627 
                 5.968 
                 −3.882 
                 0.000 
                 0.018 
                 0.082 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000130203 
                 APOE 
                 1.717 
                 6.301 
                 3.890 
                 0.000 
                 0.018 
                 0.117 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000107551 
                 RASSF4 
                 1.477 
                 6.337 
                 3.890 
                 0.000 
                 0.018 
                 0.119 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000160703 
                 NLRX1 
                 1.657 
                 4.334 
                 3.899 
                 0.000 
                 0.018 
                 0.166 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000146094 
                 DOK3 
                 1.584 
                 4.438 
                 3.897 
                 0.000 
                 0.018 
                 0.162 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000174306 
                 ZHX3 
                 1.103 
                 5.962 
                 3.893 
                 0.000 
                 0.018 
                 0.123 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000185551 
                 NR2F2 
                 −0.800 
                 5.224 
                 −3.893 
                 0.000 
                 0.018 
                 0.123 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000103415 
                 HMOX2 
                 0.781 
                 5.241 
                 3.903 
                 0.000 
                 0.018 
                 0.169 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000161040 
                 FBXL13 
                 −1.424 
                 2.510 
                 −3.902 
                 0.000 
                 0.018 
                 0.183 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000157833 
                 GAREM2 
                 −2.325 
                 3.944 
                 −3.911 
                 0.000 
                 0.018 
                 0.188 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000100038 
                 TOP3B 
                 0.653 
                 5.160 
                 3.909 
                 0.000 
                 0.018 
                 0.179 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000258890 
                 CEP95 
                 −0.604 
                 5.941 
                 −3.910 
                 0.000 
                 0.018 
                 0.153 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000144597 
                 EAF1 
                 0.730 
                 5.327 
                 3.913 
                 0.000 
                 0.018 
                 0.200 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000130830 
                 MPP1 
                 1.303 
                 4.241 
                 3.919 
                 0.000 
                 0.018 
                 0.227 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000161791 
                 FMNL3 
                 0.847 
                 7.528 
                 3.920 
                 0.000 
                 0.018 
                 0.165 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000174428 
                 GTF2IRD2B 
                 −1.028 
                 4.989 
                 −3.918 
                 0.000 
                 0.018 
                 0.208 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000163453 
                 IGFBP7 
                 1.129 
                 7.045 
                 3.928 
                 0.000 
                 0.017 
                 0.198 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000088812 
                 ATRN 
                 −0.898 
                 6.782 
                 −3.934 
                 0.000 
                 0.017 
                 0.210 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000204103 
                 MAFB 
                 1.265 
                 6.556 
                 3.938 
                 0.000 
                 0.017 
                 0.243 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000261371 
                 PECAM1 
                 1.131 
                 6.787 
                 3.937 
                 0.000 
                 0.017 
                 0.242 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000066336 
                 SPI1 
                 1.197 
                 4.610 
                 3.942 
                 0.000 
                 0.017 
                 0.287 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000182093 
                 WRB 
                 −0.688 
                 3.575 
                 −3.961 
                 0.000 
                 0.016 
                 0.341 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000005156 
                 LIG3 
                 −0.775 
                 6.498 
                 −3.970 
                 0.000 
                 0.016 
                 0.316 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000175489 
                 LRRC25 
                 1.029 
                 3.420 
                 3.973 
                 0.000 
                 0.016 
                 0.373 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000019582 
                 CD74 
                 1.285 
                 10.000 
                 3.979 
                 0.000 
                 0.016 
                 0.331 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000173546 
                 CSPG4 
                 −1.951 
                 6.339 
                 −3.981 
                 0.000 
                 0.016 
                 0.347 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000124702 
                 KLHDC3 
                 −0.624 
                 5.308 
                 −3.980 
                 0.000 
                 0.016 
                 0.367 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000077238 
                 IL4R 
                 1.477 
                 7.293 
                 3.987 
                 0.000 
                 0.016 
                 0.356 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000196954 
                 CASP4 
                 1.251 
                 6.337 
                 3.988 
                 0.000 
                 0.015 
                 0.399 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000155465 
                 SLC7A7 
                 1.180 
                 4.553 
                 3.986 
                 0.000 
                 0.015 
                 0.408 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000177663 
                 ID7RA 
                 0.933 
                 6.232 
                 3.986 
                 0.000 
                 0.015 
                 0.374 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000198959 
                 TGM2 
                 1.788 
                 7.010 
                 3.995 
                 0.000 
                 0.015 
                 0.388 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000068028 
                 RASSF1 
                 0.870 
                 4.918 
                 3.991 
                 0.000 
                 0.015 
                 0.419 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000155760 
                 FZD7 
                 −1.251 
                 4.506 
                 −4.001 
                 0.000 
                 0.015 
                 0.429 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000170248 
                 PDCD6IP 
                 0.704 
                 7.192 
                 4.008 
                 0.000 
                 0.015 
                 0.420 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000095002 
                 MSH2 
                 −1.205 
                 5.261 
                 −4.012 
                 0.000 
                 0.015 
                 0.464 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000161638 
                 ITGA5 
                 1.769 
                 7.393 
                 4.026 
                 0.000 
                 0.014 
                 0.462 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000172572 
                 PDE3A 
                 1.744 
                 4.914 
                 4.031 
                 0.000 
                 0.014 
                 0.517 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000100109 
                 TFIP11 
                 0.721 
                 5.200 
                 4.027 
                 0.000 
                 0.014 
                 0.507 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000125871 
                 MGME1 
                 −0.821 
                 5.194 
                 −4.030 
                 0.000 
                 0.014 
                 0.517 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000181690 
                 PLAG1 
                 −1.548 
                 4.011 
                 −4.035 
                 0.000 
                 0.014 
                 0.514 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000021645 
                 NRXN3 
                 −2.548 
                 3.544 
                 −4.037 
                 0.000 
                 0.014 
                 0.537 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000139436 
                 GIT2 
                 0.663 
                 6.684 
                 4.038 
                 0.000 
                 0.014 
                 0.507 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000123684 
                 LPGAT1 
                 −0.846 
                 6.922 
                 −4.040 
                 0.000 
                 0.014 
                 0.506 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000067064 
                 IDI1 
                 −1.078 
                 5.279 
                 −4.040 
                 0.000 
                 0.014 
                 0.537 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000204387 
                 C6orf48 
                 −0.820 
                 5.573 
                 −4.056 
                 0.000 
                 0.014 
                 0.577 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000204308 
                 RNF5 
                 −0.838 
                 4.156 
                 −4.057 
                 0.000 
                 0.014 
                 0.602 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000174010 
                 KLHL15 
                 −0.857 
                 4.561 
                 −4.055 
                 0.000 
                 0.014 
                 0.572 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000114126 
                 TFDP2 
                 −0.908 
                 6.410 
                 −4.055 
                 0.000 
                 0.014 
                 0.549 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000167037 
                 SGSM1 
                 −1.658 
                 2.684 
                 −4.065 
                 0.000 
                 0.014 
                 0.611 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000156990 
                 RPUSD3 
                 0.713 
                 4.639 
                 4.066 
                 0.000 
                 0.014 
                 0.622 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000141012 
                 GALNS 
                 0.694 
                 6.063 
                 4.064 
                 0.000 
                 0.014 
                 0.595 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000054392 
                 HHAT 
                 −1.569 
                 3.797 
                 −4.068 
                 0.000 
                 0.014 
                 0 625 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000099377 
                 HSD3B7 
                 1.410 
                 4.049 
                 4.073 
                 0.000 
                 0.014 
                 0.643 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000161091 
                 MFSD12 
                 0.824 
                 6.190 
                 4.071 
                 0.000 
                 0.014 
                 0.614 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000137821 
                 LRRC49 
                 −0.978 
                 3.597 
                 −4.071 
                 0.000 
                 0.014 
                 0.633 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000116857 
                 TMEM9 
                 −0.947 
                 4.676 
                 −4.078 
                 0.000 
                 0.014 
                 0.645 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000169554 
                 ZEB2 
                 1.602 
                 7.836 
                 4.086 
                 0.000 
                 0.013 
                 0.626 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000003402 
                 CFLAR 
                 0.771 
                 9.324 
                 4.088 
                 0.000 
                 0.013 
                 0.640 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000043462 
                 LCP2 
                 1.329 
                 5.996 
                 4.094 
                 0.000 
                 0.013 
                 0.686 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000101294 
                 HM13 
                 0.720 
                 6.940 
                 4.091 
                 0.000 
                 0.013 
                 0.649 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000125743 
                 SNRPD2 
                 −0.775 
                 5.122 
                 −4.090 
                 0.000 
                 0.013 
                 0.675 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000148841 
                 ITPRIP 
                 1.311 
                 6.528 
                 4.104 
                 0.000 
                 0.013 
                 0.695 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000141098 
                 GFOD2 
                 0.911 
                 5.815 
                 4.103 
                 0.000 
                 0.013 
                 0.709 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000130429 
                 ARPC1B 
                 0.759 
                 7.152 
                 4.099 
                 0.000 
                 0.013 
                 0.684 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000148143 
                 ZNF462 
                 −1.348 
                 6.566 
                 −4.103 
                 0.000 
                 0.013 
                 0.679 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000059588 
                 TARBP1 
                 −0.958 
                 6.775 
                 −4.110 
                 0.000 
                 0.013 
                 0.702 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000177042 
                 TMEM80 
                 0.871 
                 4.810 
                 4.117 
                 0.000 
                 0.013 
                 0.760 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000213648 
                 SULT1A4 
                 1.562 
                 2.810 
                 4.128 
                 0.000 
                 0.013 
                 0.785 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000160613 
                 PCSK7 
                 0.752 
                 7.889 
                 4.129 
                 0.000 
                 0.013 
                 0.751 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000113504 
                 SLC12A7 
                 −1.018 
                 6.370 
                 −4.128 
                 0.000 
                 0.013 
                 0.754 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000197249 
                 SERPINA1 
                 2.096 
                 4.599 
                 4.140 
                 0.000 
                 0.013 
                 0.819 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000197892 
                 KIF13B 
                 1.024 
                 6.143 
                 4.135 
                 0.000 
                 0.013 
                 0.796 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000138002 
                 IFT172 
                 −0.899 
                 4.913 
                 −4.153 
                 0.000 
                 0.012 
                 0.854 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000166250 
                 CLMP 
                 1.918 
                 5.567 
                 4.166 
                 0.000 
                 0.012 
                 0.890 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000158869 
                 FCER1G 
                 1.508 
                 4.294 
                 4.168 
                 0.000 
                 0.012 
                 0.902 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000112419 
                 PHACTR2 
                 0.872 
                 6.741 
                 4.165 
                 0.000 
                 0.012 
                 0.861 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000079459 
                 FDFT1 
                 −0.998 
                 5.779 
                 −4.171 
                 0.000 
                 0.012 
                 0.881 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000105538 
                 RASIP1 
                 1.477 
                 3.235 
                 4.175 
                 0.000 
                 0.012 
                 0.913 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000163703 
                 CRELD1 
                 1.178 
                 3.910 
                 4.178 
                 0.000 
                 0.012 
                 0.930 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000140829 
                 DHX38 
                 0.652 
                 6.096 
                 4.175 
                 0.000 
                 0.012 
                 0.906 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000035687 
                 ADSS 
                 −0.668 
                 6.078 
                 −4.184 
                 0.000 
                 0.012 
                 0.919 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000213930 
                 GALT 
                 −1.003 
                 4.948 
                 −4.174 
                 0.000 
                 0.012 
                 0.922 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000110436 
                 SLC1A2 
                 −2.900 
                 3.190 
                 −4.184 
                 0.000 
                 0.012 
                 0.933 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000010539 
                 ZNF200 
                 0.734 
                 4.670 
                 4.188 
                 0.000 
                 0.012 
                 0.960 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000138604 
                 GLCE 
                 −1.033 
                 4.922 
                 −4.192 
                 0.000 
                 0.012 
                 0.951 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000030582 
                 GRN 
                 1.002 
                 7.747 
                 4.197 
                 0.000 
                 0.012 
                 0.948 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000120860 
                 CCDC53 
                 0.854 
                 4.073 
                 4.196 
                 0.000 
                 0.012 
                 0.981 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000103496 
                 STX4 
                 0.733 
                 5.452 
                 4.195 
                 0.000 
                 0.012 
                 0.979 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000048471 
                 SNX29 
                 0.956 
                 6.604 
                 4.205 
                 0.000 
                 0.011 
                 0.990 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000271503 
                 CCL5 
                 1.562 
                 4.877 
                 4.227 
                 0.000 
                 0.011 
                 1.065 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000149577 
                 SIDT2 
                 0.839 
                 6.053 
                 4.224 
                 0.000 
                 0.011 
                 1.051 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000136205 
                 TNS3 
                 1.116 
                 7.632 
                 4.230 
                 0.000 
                 0.011 
                 1.044 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000166927 
                 MS4A7 
                 2.144 
                 5.592 
                 4.247 
                 0.000 
                 0.011 
                 1.115 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000159640 
                 ACE 
                 1.889 
                 4.406 
                 4.250 
                 0.000 
                 0.011 
                 1.124 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000135709 
                 KIAA0513 
                 1.633 
                 5.999 
                 4.254 
                 0.000 
                 0.011 
                 1.138 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000175899 
                 A2M 
                 1.433 
                 7.554 
                 4.242 
                 0.000 
                 0.011 
                 1.089 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000183864 
                 TOB2 
                 0.977 
                 6.160 
                 4.235 
                 0.000 
                 0.011 
                 1.070 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000128294 
                 TPST2 
                 0.944 
                 5.303 
                 4.249 
                 0.000 
                 0.011 
                 1.128 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000039523 
                 FAM65A 
                 0.932 
                 6.034 
                 4.235 
                 0.000 
                 0.011 
                 1.080 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000135090 
                 TAOK3 
                 0.698 
                 6.128 
                 4.233 
                 0.000 
                 0.011 
                 1.079 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000172379 
                 ARNT2 
                 −2.357 
                 3.551 
                 −4.247 
                 0.000 
                 0.011 
                 1.112 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000159189 
                 C1QC 
                 1.799 
                 5.953 
                 4.261 
                 0.000 
                 0.011 
                 1.154 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000090861 
                 AARS 
                 0.795 
                 6.435 
                 4.265 
                 0.000 
                 0.010 
                 1.157 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000186818 
                 LILRB4 
                 1.838 
                 4.655 
                 4.274 
                 0.000 
                 0.010 
                 1.192 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000140859 
                 KIFC3 
                 1.225 
                 6.109 
                 4.283 
                 0.000 
                 0.010 
                 1.214 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000152492 
                 CCDC50 
                 −0.767 
                 6.881 
                 −4.281 
                 0.000 
                 0.010 
                 1.190 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000011523 
                 CEP68 
                 −1.141 
                 6.164 
                 −4.296 
                 0.000 
                 0.010 
                 1.242 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000105426 
                 PTPRS 
                 −1.434 
                 6.684 
                 −4.299 
                 0.000 
                 0.010 
                 1.234 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000170458 
                 CD14 
                 1.843 
                 4.771 
                 4.304 
                 0.000 
                 0.010 
                 1.276 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000176927 
                 EFCAB5 
                 1.110 
                 2.790 
                 4.310 
                 0.000 
                 0.010 
                 1.288 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000121904 
                 CSMD2 
                 2.667 
                 3.400 
                 4.317 
                 0.000 
                 0.010 
                 1.304 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000177383 
                 MAGEF1 
                 −0.843 
                 4.429 
                 −4.325 
                 0.000 
                 0.009 
                 1.343 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000121989 
                 ACVR2A 
                 −1.153 
                 4.973 
                 −4.327 
                 0.000 
                 0.009 
                 1.350 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000103005 
                 USB1 
                 1.043 
                 5.695 
                 4.337 
                 0.000 
                 0.009 
                 1.377 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000136867 
                 SLC31A2 
                 1.456 
                 5.009 
                 4.361 
                 0.000 
                 0.009 
                 1.445 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000151632 
                 AKR1C2 
                 −1.842 
                 5.150 
                 −4.368 
                 0.000 
                 0.009 
                 1.454 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000161955 
                 TNFSF13 
                 1.263 
                 4.314 
                 4.367 
                 0.000 
                 0.009 
                 1.465 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000135636 
                 DYSF 
                 2.136 
                 5.415 
                 4.377 
                 0.000 
                 0.009 
                 1.481 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000100055 
                 CYTH4 
                 1.355 
                 5.662 
                 4.379 
                 0.000 
                 0.009 
                 1.497 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000196418 
                 ZNF124 
                 −0.856 
                 5.095 
                 −4.379 
                 0.000 
                 0.009 
                 1.492 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000173597 
                 SULT1B1 
                 −0.919 
                 8.530 
                 −4.374 
                 0.000 
                 0.009 
                 1.458 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000144749 
                 LRIG1 
                 −1.070 
                 5.807 
                 −4.372 
                 0.000 
                 0.009 
                 1.460 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000087266 
                 SH3BP2 
                 1.010 
                 7.638 
                 4.399 
                 0.000 
                 0.008 
                 1.531 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000160223 
                 ICOSLG 
                 −1.324 
                 5.371 
                 −4.399 
                 0.000 
                 0.008 
                 1.540 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000216490 
                 IFI30 
                 1.351 
                 6.374 
                 4.410 
                 0.000 
                 0.008 
                 1.579 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000155393 
                 HEATR3 
                 0.968 
                 5.028 
                 4.412 
                 0.000 
                 0.008 
                 1.593 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000101160 
                 CTSZ 
                 0.881 
                 6.724 
                 4.413 
                 0.000 
                 0.008 
                 1.581 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000110077 
                 MS4A6A 
                 1.827 
                 5.824 
                 4.430 
                 0.000 
                 0.008 
                 1.631 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000133961 
                 NUMB 
                 0.787 
                 7.036 
                 4.427 
                 0.000 
                 0.008 
                 1.622 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000142669 
                 SH3BGRL3 
                 0.926 
                 6.631 
                 4.444 
                 0.000 
                 0.008 
                 1.676 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000149131 
                 SERPING1 
                 2.053 
                 6.271 
                 4.460 
                 0.000 
                 0.007 
                 1.718 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000088930 
                 XRN2 
                 −0.812 
                 6.663 
                 −4.459 
                 0.000 
                 0.007 
                 1.714 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000122778 
                 KIAA1549 
                 −1.107 
                 4.167 
                 −4.457 
                 0.000 
                 0.007 
                 1.720 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000011600 
                 TYROBP 
                 1.536 
                 3.824 
                 4.466 
                 0.000 
                 0.007 
                 1.724 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000104177 
                 MYEF2 
                 −1.397 
                 4.015 
                 −4.469 
                 0.000 
                 0.007 
                 1.757 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000131042 
                 LILRB2 
                 2.149 
                 3.751 
                 4.509 
                 0.000 
                 0.007 
                 1.838 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000135723 
                 FHOD1 
                 0.797 
                 5.640 
                 4.513 
                 0.000 
                 0.007 
                 1.882 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000107186 
                 MPDZ 
                 −1.977 
                 5.315 
                 −4.520 
                 0.000 
                 0.007 
                 1.888 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000168461 
                 RAB31 
                 1.537 
                 7.199 
                 4.554 
                 0.000 
                 0.006 
                 1.982 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000173559 
                 NABP1 
                 1.120 
                 8.027 
                 4.571 
                 0.000 
                 0.006 
                 2.036 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000185630 
                 PBX1 
                 −1.172 
                 6.170 
                 −4.569 
                 0.000 
                 0.006 
                 2.032 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000163359 
                 COL6A3 
                 2.093 
                 10.354 
                 4.583 
                 0.000 
                 0.006 
                 2.065 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000125810 
                 CD93 
                 1.526 
                 6.515 
                 4.603 
                 0.000 
                 0.005 
                 2.132 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000141837 
                 CACNA1A 
                 −1.247 
                 5.706 
                 −4.603 
                 0.000 
                 0.005 
                 2.141 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000173372 
                 C1QA 
                 2.246 
                 5.769 
                 4.633 
                 0.000 
                 0.005 
                 2.210 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000173369 
                 C1QB 
                 2.189 
                 5.963 
                 4.628 
                 0.000 
                 0.005 
                 2.201 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000158714 
                 SLAMF8 
                 1.849 
                 4.665 
                 4.623 
                 0.000 
                 0.005 
                 2.164 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000140350 
                 ANP32A 
                 −0.817 
                 6.484 
                 −4.616 
                 0.000 
                 0.005 
                 2.172 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000154930 
                 ACSS1 
                 −1.394 
                 5.683 
                 −4.622 
                 0.000 
                 0.005 
                 2.188 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000187134 
                 AKR1C1 
                 −2.106 
                 5.668 
                 −4.631 
                 0.000 
                 0.005 
                 2.210 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000166278 
                 C2 
                 1.936 
                 5.364 
                 4.654 
                 0.000 
                 0.005 
                 2.268 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000198315 
                 ZKSCAN8 
                 −0.681 
                 6.353 
                 −4.661 
                 0.000 
                 0.005 
                 2.304 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000109861 
                 CTSC 
                 1.813 
                 8.068 
                 4.677 
                 0.000 
                 0.005 
                 2.338 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000167613 
                 LAIR1 
                 1.686 
                 5.707 
                 4.673 
                 0.000 
                 0.005 
                 2.335 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000172215 
                 CXCR6 
                 1.407 
                 3.773 
                 4.695 
                 0.000 
                 0.005 
                 2.379 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000013364 
                 MVP 
                 1.074 
                 7.190 
                 4.685 
                 0.000 
                 0.005 
                 2.379 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000124120 
                 TTPAL 
                 1.052 
                 6.379 
                 4.683 
                 0.000 
                 0.005 
                 2.375 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000247315 
                 ZCCHC3 
                 −0.837 
                 4.571 
                 −4.677 
                 0.000 
                 0.005 
                 2.360 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000196391 
                 ZNF774 
                 −1.133 
                 3.976 
                 −4.678 
                 0.000 
                 0.005 
                 2.359 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000198075 
                 SULT1C4 
                 −1.220 
                 2.070 
                 −4.689 
                 0.000 
                 0.005 
                 2.338 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000066468 
                 FGFR2 
                 −1.727 
                 5.366 
                 −4.710 
                 0.000 
                 0.005 
                 2.442 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000173726 
                 TOMM20 
                 −0.947 
                 7.329 
                 −4.711 
                 0.000 
                 0.005 
                 2.451 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000171860 
                 C3AR1 
                 2.128 
                 3.620 
                 4.728 
                 0.000 
                 0.005 
                 2.443 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000198805 
                 PNP 
                 1.459 
                 5.417 
                 4.731 
                 0.000 
                 0.005 
                 2.493 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000072786 
                 STK10 
                 1.046 
                 6.579 
                 4.749 
                 0.000 
                 0.005 
                 2.568 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000129566 
                 TEP1 
                 0.987 
                 7.063 
                 4.724 
                 0.000 
                 0.005 
                 2.495 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000196535 
                 MYO18A 
                 0.926 
                 7.449 
                 4.722 
                 0.000 
                 0.005 
                 2.487 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000138131 
                 LOXL4 
                 −1.749 
                 3.008 
                 −4.751 
                 0.000 
                 0.005 
                 2.559 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000185920 
                 PTCH1 
                 −2.062 
                 5.125 
                 −4.742 
                 0.000 
                 0.005 
                 2.536 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000102575 
                 ACP5 
                 1.843 
                 5.001 
                 4.768 
                 0.000 
                 0.005 
                 2.594 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000145685 
                 LHFPL2 
                 1.293 
                 6.653 
                 4.775 
                 0.000 
                 0.005 
                 2.647 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000073921 
                 PICALM 
                 0.673 
                 7.903 
                 4.762 
                 0.000 
                 0.005 
                 2.601 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000147862 
                 NFIB 
                 −1.897 
                 7.469 
                 −4.777 
                 0.000 
                 0.005 
                 2.633 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000114738 
                 MAPKAPK3 
                 1.008 
                 4.995 
                 4.792 
                 0.000 
                 0.005 
                 2.682 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000181744 
                 C3orf58 
                 −1.245 
                 5.562 
                 −4.790 
                 0.000 
                 0.005 
                 2.688 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000129226 
                 CD68 
                 1.802 
                 6.067 
                 4.815 
                 0.000 
                 0.004 
                 2.742 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000171262 
                 FAM98B 
                 −1.022 
                 5.614 
                 −4.833 
                 0.000 
                 0.004 
                 2.820 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000172243 
                 CLEC7A 
                 1.499 
                 5.358 
                 4.848 
                 0.000 
                 0.004 
                 2.849 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000106991 
                 ENG 
                 1.096 
                 6.195 
                 4.878 
                 0.000 
                 0.004 
                 2.953 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000205189 
                 ZBTB10 
                 −1.445 
                 5.508 
                 −4.886 
                 0.000 
                 0.004 
                 2.970 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000125779 
                 PANK2 
                 −0.777 
                 6.065 
                 −4.904 
                 0.000 
                 0.004 
                 3.030 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000008441 
                 NFIX 
                 −1.695 
                 6.265 
                 −4.930 
                 0.000 
                 0.003 
                 3.092 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000100600 
                 LGMN 
                 1.297 
                 6.142 
                 4.938 
                 0.000 
                 0.003 
                 3.126 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000175220 
                 ARHGAP1 
                 0.876 
                 7.060 
                 4.952 
                 0.000 
                 0.003 
                 3.171 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000117625 
                 RCOR3 
                 −0.839 
                 6.259 
                 −4.939 
                 0.000 
                 0.003 
                 3.134 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000168795 
                 ZBTB5 
                 −0.897 
                 5.293 
                 −4.954 
                 0.000 
                 0.003 
                 3.178 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000117906 
                 RCN2 
                 −1.183 
                 6.177 
                 −4.956 
                 0.000 
                 0.003 
                 3.187 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000160439 
                 RDH13 
                 1.329 
                 5.578 
                 4.979 
                 0.000 
                 0.003 
                 3.252 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000081913 
                 PHLPP1 
                 −1.185 
                 5.292 
                 −4.981 
                 0.000 
                 0.003 
                 3.260 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000171310 
                 CHST11 
                 1.208 
                 6.371 
                 5.001 
                 0.000 
                 0.003 
                 3.319 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000120451 
                 SNX19 
                 0.737 
                 6.775 
                 5.013 
                 0.000 
                 0.003 
                 3.356 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000164758 
                 MED30 
                 −1.180 
                 2.905 
                 −5.003 
                 0.000 
                 0.003 
                 3.257 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000160679 
                 CHTOP 
                 −0.706 
                 6.573 
                 −5.027 
                 0.000 
                 0.003 
                 3.399 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000118007 
                 STAG1 
                 −0.769 
                 6.758 
                 −5.061 
                 0.000 
                 0.003 
                 3.500 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000092421 
                 SEMA6A 
                 −1.880 
                 5.149 
                 −5.068 
                 0.000 
                 0.003 
                 3.504 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000136158 
                 SPRY2 
                 −1.931 
                 3.968 
                 −5.093 
                 0.000 
                 0.003 
                 3.562 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000143226 
                 FCGR2A 
                 2.541 
                 5.987 
                 5.117 
                 0.000 
                 0.003 
                 3.615 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000154127 
                 UBASH3B 
                 1.717 
                 5.263 
                 5.137 
                 0.000 
                 0.003 
                 3.691 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000145246 
                 ATP10D 
                 1.572 
                 6.334 
                 5.155 
                 0.000 
                 0.003 
                 3.769 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000163041 
                 H3F3A 
                 −0.838 
                 7.837 
                 −5.152 
                 0.000 
                 0.003 
                 3.775 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000118707 
                 TGIF2 
                 −1.402 
                 5.349 
                 −5.167 
                 0.000 
                 0.003 
                 3.819 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000103043 
                 VAC14 
                 0.827 
                 6.196 
                 5.194 
                 0.000 
                 0.002 
                 3.896 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000112379 
                 ARFGEF3 
                 −1.509 
                 3.894 
                 −5.199 
                 0.000 
                 0.002 
                 3.907 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000198668 
                 CALM1 
                 1.110 
                 8.268 
                 5.241 
                 0.000 
                 0.002 
                 4.046 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000159720 
                 ATP6V0D1 
                 0.942 
                 6.186 
                 5.232 
                 0.000 
                 0.002 
                 4.010 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000137070 
                 IL11RA 
                 −1.935 
                 4.816 
                 −5.274 
                 0.000 
                 0.002 
                 4.090 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000205250 
                 E2F4 
                 0.870 
                 6.046 
                 5.340 
                 0.000 
                 0.002 
                 4.336 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000137103 
                 TMEM8B 
                 −1.908 
                 3.219 
                 −5.355 
                 0.000 
                 0.002 
                 4.324 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000137491 
                 SLCO2B1 
                 1.939 
                 7.133 
                 5.387 
                 0.000 
                 0.002 
                 4.448 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000071575 
                 TRIB2 
                 −1.148 
                 6.350 
                 −5.379 
                 0.000 
                 0.002 
                 4.464 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000136869 
                 TLR4 
                 2.678 
                 5.010 
                 5.616 
                 0.000 
                 0.002 
                 5.045 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000184060 
                 ADAP2 
                 2.061 
                 4.480 
                 5.590 
                 0.000 
                 0.002 
                 4.972 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000135047 
                 CTSL 
                 1.842 
                 5.471 
                 5.640 
                 0.000 
                 0.002 
                 5.196 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000139567 
                 ACVRL1 
                 1.840 
                 4.570 
                 5.527 
                 0.000 
                 0.002 
                 4.801 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000135077 
                 HAVCR2 
                 1.579 
                 5.005 
                 5.467 
                 0.000 
                 0.002 
                 4.668 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000064601 
                 CTSA 
                 1.146 
                 6.657 
                 5.457 
                 0.000 
                 0.002 
                 4.698 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000188997 
                 KCTD21 
                 1.071 
                 4.129 
                 5.493 
                 0.000 
                 0.002 
                 4.721 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000099949 
                 LZTR1 
                 0.951 
                 6.255 
                 5.516 
                 0.000 
                 0.002 
                 4.874 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000154144 
                 TBRG1 
                 0.827 
                 5.684 
                 5.643 
                 0.000 
                 0.002 
                 5.231 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000169105 
                 CHST14 
                 −1.246 
                 3.970 
                 −5.505 
                 0.000 
                 0.002 
                 4.783 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000165434 
                 PGM2L1 
                 −1.426 
                 5.364 
                 −5.448 
                 0.000 
                 0.002 
                 4.639 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000125247 
                 TMTC4 
                 −1.500 
                 4.180 
                 −5.560 
                 0.000 
                 0.002 
                 4.912 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000138336 
                 TET1 
                 −1.591 
                 3.684 
                 −5.639 
                 0.000 
                 0.002 
                 5.173 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000260314 
                 MRC1 
                 3.604 
                 5.521 
                 5.928 
                 0.000 
                 0.001 
                 5.965 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000021574 
                 SPAST 
                 −1.080 
                 5.644 
                 −6.288 
                 0.000 
                 0.000 
                 7.239 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000154359 
                 LONRF1 
                 −1.921 
                 5.042 
                 −6.382 
                 0.000 
                 0.000 
                 7.487 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000064651 
                 SLC12A2 
                 −1.988 
                 6.081 
                 −6.238 
                 0.000 
                 0.000 
                 7.058 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000180730 
                 SHISA2 
                 −2.880 
                 2.447 
                 −6.519 
                 0.000 
                 0.000 
                 7.848 
               
               
                 LNM Group 2 vs. Group 3 
                 ENSG00000116016 
                 EPAS1 
                 2.009 
                 7.912 
                 9.032 
                 0.000 
                 0.000 
                 15.323 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198838 
                 RYR3 
                 2.928 
                 5.479 
                 4.916 
                 0.000 
                 0.002 
                 3.048 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000180730 
                 SHISA2 
                 2.838 
                 2.447 
                 7.158 
                 0.000 
                 0.000 
                 9.888 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000066468 
                 FGFR2 
                 2.408 
                 5.366 
                 7.084 
                 0.000 
                 0.000 
                 9.679 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173546 
                 CSPG4 
                 2.388 
                 6.339 
                 5.167 
                 0.000 
                 0.001 
                 3.800 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000157064 
                 NMNAT2 
                 2.331 
                 3.243 
                 3.699 
                 0.001 
                 0.013 
                 −0.394 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000177839 
                 PCDHB9 
                 2.312 
                 2.610 
                 3.696 
                 0.001 
                 0.013 
                 −0.384 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000205363 
                 C15orf59 
                 2.309 
                 3.251 
                 3.942 
                 0.000 
                 0.009 
                 0.270 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000266074 
                 BAHCC1 
                 2.219 
                 5.591 
                 5.687 
                 0.000 
                 0.001 
                 5.389 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000008441 
                 NFIX 
                 2.075 
                 6.265 
                 6.411 
                 0.000 
                 0.000 
                 7.622 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000144857 
                 BOC 
                 2.071 
                 4.934 
                 4.239 
                 0.000 
                 0.006 
                 1.071 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164638 
                 SLC29A4 
                 2.065 
                 4.079 
                 4.425 
                 0.000 
                 0.004 
                 1.608 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168389 
                 MFSD2A 
                 2.036 
                 4.277 
                 3.931 
                 0.000 
                 0.009 
                 0.238 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000147862 
                 NFIB 
                 1.945 
                 7.469 
                 5.187 
                 0.000 
                 0.001 
                 3.858 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000088836 
                 SLC4A11 
                 1.932 
                 3.943 
                 4.146 
                 0.000 
                 0.007 
                 0.803 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000116962 
                 NID1 
                 1.878 
                 6.963 
                 4.782 
                 0.000 
                 0.002 
                 2.634 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000064651 
                 SLC12A2 
                 1.876 
                 6.081 
                 6.260 
                 0.000 
                 0.000 
                 7.163 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000021645 
                 NRXN3 
                 1.873 
                 3.544 
                 3.154 
                 0.003 
                 0.035 
                 −1.763 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138696 
                 BMPR1B 
                 1.854 
                 3.687 
                 3.332 
                 0.002 
                 0.026 
                 −1.374 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000155380 
                 SLC16A1 
                 1.845 
                 6.332 
                 4.245 
                 0.000 
                 0.006 
                 1.069 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114115 
                 RBP1 
                 1.832 
                 4.600 
                 4.439 
                 0.000 
                 0.004 
                 1.635 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000151967 
                 SCHIP1 
                 1.797 
                 4.715 
                 3.778 
                 0.001 
                 0.012 
                 −0.225 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000161040 
                 FBXL13 
                 1.791 
                 2.510 
                 5.247 
                 0.000 
                 0.001 
                 4.014 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000187134 
                 AKR1C1 
                 1.756 
                 5.668 
                 4.154 
                 0.000 
                 0.006 
                 0.821 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000148143 
                 ZNF462 
                 1.750 
                 6.566 
                 5.657 
                 0.000 
                 0.001 
                 5.299 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000107186 
                 MPDZ 
                 1.726 
                 5.315 
                 4.225 
                 0.000 
                 0.006 
                 1.015 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000157833 
                 GAREM2 
                 1.684 
                 3.944 
                 3.080 
                 0.004 
                 0.040 
                 −2.003 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185565 
                 LSAMP 
                 1.682 
                 5.469 
                 3.140 
                 0.003 
                 0.036 
                 −1.946 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000107338 
                 SHB 
                 1.652 
                 4.763 
                 4.921 
                 0.000 
                 0.002 
                 3.062 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136158 
                 SPRY2 
                 1.648 
                 3.968 
                 4.714 
                 0.000 
                 0.003 
                 2.452 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130821 
                 SLC6A8 
                 1.642 
                 6.543 
                 2.941 
                 0.005 
                 0.049 
                 −2.437 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000157240 
                 FZD1 
                 1.638 
                 5.242 
                 4.276 
                 0.000 
                 0.006 
                 1.167 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000117394 
                 SLC2A1 
                 1.636 
                 8.211 
                 3.296 
                 0.002 
                 0.027 
                 −1.554 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172986 
                 GXYLT2 
                 1.632 
                 4.575 
                 3.212 
                 0.003 
                 0.032 
                 −1.691 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100994 
                 PYGB 
                 1.629 
                 7.445 
                 4.802 
                 0.000 
                 0.002 
                 2.689 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164684 
                 ZNF704 
                 1.624 
                 5.657 
                 3.558 
                 0.001 
                 0.017 
                 −0.849 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000092068 
                 SLC7A8 
                 1.619 
                 6.411 
                 3.478 
                 0.001 
                 0.020 
                 −1.037 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143842 
                 SOX13 
                 1.618 
                 5.384 
                 6.491 
                 0.000 
                 0.000 
                 7.893 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000119326 
                 CTNNAL1 
                 1.617 
                 4.654 
                 3.576 
                 0.001 
                 0.016 
                 −0.769 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000141934 
                 PLPP2 
                 1.609 
                 5.943 
                 3.596 
                 0.001 
                 0.016 
                 −0.754 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000187244 
                 BCAM 
                 1.600 
                 6.078 
                 3.962 
                 0.000 
                 0.009 
                 0.243 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000128567 
                 PODXL 
                 1.598 
                 6.146 
                 4.739 
                 0.000 
                 0.003 
                 2.505 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000155760 
                 FZD7 
                 1.579 
                 4.506 
                 5.447 
                 0.000 
                 0.001 
                 4.668 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166813 
                 KIF7 
                 1.572 
                 3.863 
                 4.053 
                 0.000 
                 0.008 
                 0.549 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000175832 
                 ETV4 
                 1.560 
                 3.719 
                 4.927 
                 0.000 
                 0.002 
                 3.089 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000109654 
                 TRIM2 
                 1.554 
                 5.906 
                 5.129 
                 0.000 
                 0.001 
                 3.683 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101004 
                 NINL 
                 1.551 
                 4.878 
                 4.996 
                 0.000 
                 0.002 
                 3.295 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143153 
                 ATP1B1 
                 1.549 
                 6.955 
                 3.923 
                 0.000 
                 0.009 
                 0.147 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000116128 
                 BCL9 
                 1.534 
                 4.976 
                 5.022 
                 0.000 
                 0.002 
                 3.376 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000205213 
                 LGR4 
                 1.512 
                 5.154 
                 5.076 
                 0.000 
                 0.001 
                 3.535 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000106484 
                 MEST 
                 1.499 
                 4.857 
                 3.461 
                 0.001 
                 0.021 
                 −1.069 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000053108 
                 FSTL4 
                 1.495 
                 3.588 
                 4.274 
                 0.000 
                 0.006 
                 1.186 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000141542 
                 RAB40B 
                 1.495 
                 3.896 
                 4.064 
                 0.000 
                 0.007 
                 0.584 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000151208 
                 DLG5 
                 1.481 
                 7.342 
                 3.222 
                 0.002 
                 0.031 
                 −1.746 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000179431 
                 FJX1 
                 1.479 
                 4.001 
                 3.318 
                 0.002 
                 0.026 
                 −1.385 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125841 
                 NRSN2 
                 1.478 
                 4.000 
                 5.332 
                 0.000 
                 0.001 
                 4.315 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000142632 
                 ARHGEF19 
                 1.475 
                 4.527 
                 5.011 
                 0.000 
                 0.002 
                 3.344 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188153 
                 COL4A5 
                 1.469 
                 6.757 
                 3.853 
                 0.000 
                 0.010 
                 −0.063 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162337 
                 LRP5 
                 1.466 
                 5.883 
                 4.304 
                 0.000 
                 0.005 
                 1.227 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162738 
                 VANGL2 
                 1.466 
                 5.578 
                 3.797 
                 0.000 
                 0.011 
                 −0.202 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000169908 
                 TM4SF1 
                 1.456 
                 6.782 
                 3.345 
                 0.002 
                 0.025 
                 −1.420 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000006468 
                 ETV1 
                 1.451 
                 3.276 
                 3.442 
                 0.001 
                 0.021 
                 −1.106 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185920 
                 PTCH1 
                 1.437 
                 5.125 
                 3.580 
                 0.001 
                 0.016 
                 −0.782 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164171 
                 ITGA2 
                 1.422 
                 7.280 
                 4.134 
                 0.000 
                 0.007 
                 0.730 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000092421 
                 SEMA6A 
                 1.420 
                 5.149 
                 4.125 
                 0.000 
                 0.007 
                 0.713 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137103 
                 TMEM8B 
                 1.419 
                 3.219 
                 4.325 
                 0.000 
                 0.005 
                 1.334 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000124766 
                 SOX4 
                 1.417 
                 6.606 
                 4.098 
                 0.000 
                 0.007 
                 0.625 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185842 
                 DNAH14 
                 1.415 
                 4.374 
                 3.887 
                 0.000 
                 0.010 
                 0.045 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000151917 
                 BEND6 
                 1.406 
                 3.101 
                 4.030 
                 0.000 
                 0.008 
                 0.503 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000154359 
                 LONRF1 
                 1.406 
                 5.042 
                 5.052 
                 0.000 
                 0.002 
                 3.467 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000072682 
                 P4HA2 
                 1.404 
                 5.644 
                 3.065 
                 0.004 
                 0.041 
                 −2.012 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000204580 
                 DDR1 
                 1.399 
                 8.303 
                 3.558 
                 0.001 
                 0.017 
                 −0.863 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000112715 
                 VEGFA 
                 1.396 
                 8.135 
                 3.382 
                 0.002 
                 0.024 
                 −1.324 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000178896 
                 EXOSC4 
                 1.389 
                 3.234 
                 3.413 
                 0.001 
                 0.022 
                 −1.149 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000181588 
                 MEX3D 
                 1.389 
                 4.514 
                 4.559 
                 0.000 
                 0.003 
                 1.995 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000079462 
                 PAFAH1B3 
                 1.375 
                 2.958 
                 4.948 
                 0.000 
                 0.002 
                 3.136 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114270 
                 COL7A1 
                 1.374 
                 9.645 
                 3.056 
                 0.004 
                 0.041 
                 −2.135 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000070087 
                 PFN2 
                 1.371 
                 5.885 
                 3.542 
                 0.001 
                 0.018 
                 −0.905 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000105426 
                 PTPRS 
                 1.371 
                 6.684 
                 4.375 
                 0.000 
                 0.005 
                 1.424 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000117266 
                 CDK18 
                 1.366 
                 5.022 
                 4.282 
                 0.000 
                 0.005 
                 1.160 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114315 
                 HES1 
                 1.361 
                 4.740 
                 3.561 
                 0.001 
                 0.017 
                 −0.790 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000006327 
                 TNFRSF12A 
                 1.358 
                 5.627 
                 3.281 
                 0.002 
                 0.028 
                 −1.527 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000186314 
                 PRELID2 
                 1.356 
                 3.508 
                 3.760 
                 0.001 
                 0.012 
                 −0.222 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000074590 
                 NUAK1 
                 1.340 
                 5.420 
                 3.182 
                 0.003 
                 0.033 
                 −1.807 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000145632 
                 PLK2 
                 1.331 
                 6.110 
                 3.396 
                 0.002 
                 0.023 
                 −1.241 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000006210 
                 CX3CL1 
                 1.324 
                 4.591 
                 2.990 
                 0.005 
                 0.046 
                 −2.285 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197763 
                 TXNRD3 
                 1.324 
                 3.503 
                 3.627 
                 0.001 
                 0.015 
                 −0.585 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137070 
                 IL11RA 
                 1.324 
                 4.816 
                 3.832 
                 0.000 
                 0.011 
                 −0.048 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173320 
                 STOX2 
                 1.321 
                 4.633 
                 3.652 
                 0.001 
                 0.014 
                 −0.582 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000115457 
                 IGFBP2 
                 1.318 
                 5.247 
                 3.083 
                 0.004 
                 0.040 
                 −2.085 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143367 
                 TUFT1 
                 1.316 
                 5.377 
                 3.094 
                 0.004 
                 0.039 
                 −2.001 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143147 
                 GPR161 
                 1.310 
                 4.831 
                 4.285 
                 0.000 
                 0.005 
                 1.198 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000244405 
                 ETV5 
                 1.309 
                 5.173 
                 3.316 
                 0.002 
                 0.026 
                 −1.497 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000006118 
                 TMEM132A 
                 1.303 
                 6.305 
                 3.315 
                 0.002 
                 0.026 
                 −1.493 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138131 
                 LOXL4 
                 1.302 
                 3.008 
                 3.872 
                 0.000 
                 0.010 
                 0.043 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164050 
                 PLXNB1 
                 1.299 
                 7.069 
                 3.615 
                 0.001 
                 0.015 
                 −0.718 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000158769 
                 F11R 
                 1.298 
                 7.648 
                 3.831 
                 0.000 
                 0.011 
                 −0.128 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000151632 
                 AKR1C2 
                 1.297 
                 5.150 
                 3.334 
                 0.002 
                 0.026 
                 −1.410 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000120549 
                 KIAA1217 
                 1.292 
                 6.908 
                 4.868 
                 0.000 
                 0.002 
                 2.901 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172893 
                 DHCR7 
                 1.291 
                 4.568 
                 3.843 
                 0.000 
                 0.010 
                 −0.040 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000152104 
                 PTPN14 
                 1.274 
                 7.852 
                 4.868 
                 0.000 
                 0.002 
                 2.904 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114023 
                 FAM162A 
                 1.260 
                 4.891 
                 3.335 
                 0.002 
                 0.026 
                 −1.383 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000131788 
                 PIAS3 
                 1.259 
                 6.048 
                 5.116 
                 0.000 
                 0.001 
                 3.666 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000111057 
                 KRT18 
                 1.257 
                 5.463 
                 3.330 
                 0.002 
                 0.026 
                 −1.452 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000140443 
                 IGF1R 
                 1.251 
                 7.946 
                 4.422 
                 0.000 
                 0.004 
                 1.574 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000110723 
                 EXPH5 
                 1.248 
                 5.394 
                 3.122 
                 0.003 
                 0.037 
                 −1.923 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101773 
                 RBBP8 
                 1.248 
                 5.858 
                 4.367 
                 0.000 
                 0.005 
                 1.412 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000243244 
                 STON1 
                 1.243 
                 5.027 
                 3.720 
                 0.001 
                 0.013 
                 −0.364 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000154358 
                 OBSCN 
                 1.234 
                 7.572 
                 3.228 
                 0.002 
                 0.031 
                 −1.728 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000112655 
                 PTK7 
                 1.232 
                 7.125 
                 3.888 
                 0.000 
                 0.010 
                 0.036 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000116857 
                 TMEM9 
                 1.225 
                 4.676 
                 5.681 
                 0.000 
                 0.001 
                 5.386 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000171867 
                 PRNP 
                 1.224 
                 7.884 
                 3.783 
                 0.000 
                 0.012 
                 −0.261 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000271303 
                 SRXN1 
                 1.214 
                 5.501 
                 3.449 
                 0.001 
                 0.021 
                 −1.100 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165264 
                 NDUFB6 
                 1.212 
                 3.568 
                 3.658 
                 0.001 
                 0.014 
                 −0.466 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138604 
                 GLCE 
                 1.209 
                 4.922 
                 5.306 
                 0.000 
                 0.001 
                 4.242 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000099203 
                 TMED1 
                 1.205 
                 3.096 
                 3.117 
                 0.003 
                 0.037 
                 −1.839 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000067141 
                 NEO1 
                 1.202 
                 5.800 
                 3.941 
                 0.000 
                 0.009 
                 1.186 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000187775 
                 DNAH17 
                 1.201 
                 5.901 
                 3.112 
                 0.003 
                 0.038 
                 −1.975 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000155254 
                 MARVELD1 
                 1.200 
                 5.663 
                 3.964 
                 0.000 
                 0.009 
                 0.319 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164070 
                 HSPA4L 
                 1.200 
                 5.893 
                 3.580 
                 0.001 
                 0.016 
                 −0.805 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000243364 
                 EFNA4 
                 1.199 
                 2.767 
                 3.836 
                 0.000 
                 0.010 
                 −0.001 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000169957 
                 ZNF768 
                 1.193 
                 4 412 
                 5.953 
                 0.000 
                 0.000 
                 6.207 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000091622 
                 PITPNM3 
                 1.192 
                 5.210 
                 3.199 
                 0.003 
                 0.033 
                 −1.761 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000102230 
                 PCYT1B 
                 1.192 
                 2.302 
                 3.191 
                 0.003 
                 0.033 
                 −1.693 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168502 
                 MTCL1 
                 1.189 
                 5.459 
                 3.992 
                 0.000 
                 0.008 
                 0.339 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000117139 
                 KDM5B 
                 1.188 
                 7.261 
                 5.069 
                 0.000 
                 0.001 
                 3.516 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166503 
                 RP11- 
                 1.184 
                 6.556 
                 4.709 
                 0.000 
                 0.003 
                 2.426 
               
               
                   
                   
                 382A20.3 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000007866 
                 TEAD3 
                 1.179 
                 5.445 
                 3.697 
                 0.001 
                 0.013 
                 −0.450 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000063660 
                 GPC1 
                 1.166 
                 7.396 
                 3.659 
                 0.001 
                 0.014 
                 −0.596 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135525 
                 MAP7 
                 1.163 
                 4.944 
                 3.317 
                 0.002 
                 0.026 
                 −1.461 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000186638 
                 KIF24 
                 1.162 
                 3.928 
                 4.356 
                 0.000 
                 0.005 
                 1.431 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000106780 
                 MEGF9 
                 1.151 
                 5.922 
                 3.849 
                 0.000 
                 0.010 
                 −0.031 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000170412 
                 GPRC5C 
                 1.149 
                 3.744 
                 3.056 
                 0.004 
                 0.041 
                 −2.061 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000118200 
                 CAMSAP2 
                 1.148 
                 6.796 
                 4.168 
                 0.000 
                 0.006 
                 0.834 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000081913 
                 PHLPP1 
                 1.142 
                 5.292 
                 5.159 
                 0.000 
                 0.001 
                 3.795 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000177732 
                 SOX12 
                 1.141 
                 4.882 
                 4.635 
                 0.000 
                 0.003 
                 2.234 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100842 
                 EFS 
                 1.141 
                 4.926 
                 3.430 
                 0.001 
                 0.022 
                 −1.157 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125843 
                 AP5S1 
                 1.139 
                 5.039 
                 4.672 
                 0.000 
                 0.003 
                 2.335 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000088812 
                 ATRN 
                 1.139 
                 6.782 
                 5.295 
                 0.000 
                 0.001 
                 4.209 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000154380 
                 ENAH 
                 1.130 
                 8.030 
                 3.578 
                 0.001 
                 0.016 
                 −0.820 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000115657 
                 ABCB6 
                 1.128 
                 4.620 
                 3.974 
                 0.000 
                 0.009 
                 0.341 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000073282 
                 TP63 
                 1.127 
                 8.375 
                 2.969 
                 0.005 
                 0.047 
                 −2.369 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166681 
                 BEX3 
                 1.124 
                 4.529 
                 3.494 
                 0.001 
                 0.019 
                 −0.956 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197586 
                 ENTPD6 
                 1.121 
                 6.144 
                 4.774 
                 0.000 
                 0.002 
                 2.625 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000106789 
                 CORO2A 
                 1.120 
                 5.676 
                 4.566 
                 0.000 
                 0.003 
                 2.010 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136026 
                 CKAP4 
                 1.118 
                 6.922 
                 3.777 
                 0.001 
                 0.012 
                 −0.278 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125247 
                 TMTC4 
                 1.118 
                 4.180 
                 4.403 
                 0.000 
                 0.004 
                 1.567 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000132640 
                 BTBD3 
                 1.115 
                 5.484 
                 3.895 
                 0.000 
                 0.010 
                 0.060 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143013 
                 LMO4 
                 1.113 
                 5.581 
                 4.052 
                 0.000 
                 0.007 
                 0.510 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160111 
                 CPAMD8 
                 1.110 
                 4.049 
                 3.636 
                 0.001 
                 0.015 
                 −0.562 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000083857 
                 FAT1 
                 1.110 
                 8.996 
                 3.325 
                 0.002 
                 0.026 
                 −1.465 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000127564 
                 PKMYT1 
                 1.109 
                 4.627 
                 2.987 
                 0.005 
                 0.046 
                 −2.219 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000090447 
                 TFAP4 
                 1.108 
                 5.040 
                 3.960 
                 0.000 
                 0.009 
                 0.279 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000154447 
                 SH3RF1 
                 1.106 
                 5.305 
                 3.844 
                 0.000 
                 0.010 
                 −0.034 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165655 
                 ZNF503 
                 1.091 
                 4.082 
                 3.106 
                 0.003 
                 0.038 
                 −1.905 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000107731 
                 UNC5B 
                 1.091 
                 6.298 
                 2.942 
                 0.005 
                 0.049 
                 −2.395 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000169105 
                 CHST14 
                 1.090 
                 3.970 
                 5.183 
                 0.000 
                 0.001 
                 3.860 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000151929 
                 BAG3 
                 1.088 
                 5.800 
                 3.655 
                 0.001 
                 0.014 
                 −0.550 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104341 
                 LAPTM4B 
                 1.088 
                 6.305 
                 3.581 
                 0.001 
                 0.016 
                 −0.771 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000082458 
                 DLG3 
                 1.085 
                 4.809 
                 3.939 
                 0.000 
                 0.009 
                 0.236 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136854 
                 STXBP1 
                 1.081 
                 4.877 
                 3.659 
                 0.001 
                 0.014 
                 −0.528 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000069849 
                 ATP1B3 
                 1.080 
                 7.022 
                 3.378 
                 0.002 
                 0.024 
                 −1.345 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000169255 
                 B3GALNT1 
                 1.079 
                 3.611 
                 3.900 
                 0.000 
                 0.009 
                 0.147 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000171603 
                 CLSTN1 
                 1.077 
                 8.118 
                 5.354 
                 0.000 
                 0.001 
                 4.390 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101871 
                 MID1 
                 1.077 
                 5.466 
                 4.095 
                 0.000 
                 0.007 
                 0.646 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000142949 
                 PTPRF 
                 1.066 
                 8.842 
                 3.394 
                 0.002 
                 0.023 
                 −1.297 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196411 
                 EPHB4 
                 1.065 
                 6.613 
                 3.689 
                 0.001 
                 0.013 
                 −0.515 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000112379 
                 ARFGEF3 
                 1.063 
                 3.894 
                 4.036 
                 0.000 
                 0.008 
                 0.479 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137135 
                 ARHGEF39 
                 1.062 
                 3.994 
                 3.396 
                 0.002 
                 0.023 
                 −1.167 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138463 
                 DIRC2 
                 1.061 
                 4.939 
                 4.666 
                 0.000 
                 0.003 
                 2.326 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000054392 
                 HHAT 
                 1.058 
                 3.797 
                 2.943 
                 0.005 
                 0.049 
                 −2.297 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125871 
                 MGME1 
                 1.054 
                 5.194 
                 5.491 
                 0.000 
                 0.001 
                 4.802 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101236 
                 RNF24 
                 1.053 
                 5.965 
                 5.518 
                 0.000 
                 0.001 
                 4.895 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000132664 
                 POLR3F 
                 1.053 
                 3.867 
                 4.589 
                 0.000 
                 0.003 
                 2.101 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000118707 
                 TGIF2 
                 1.050 
                 5.349 
                 4.169 
                 0.000 
                 0.006 
                 0.846 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000117906 
                 RCN2 
                 1.048 
                 6.177 
                 4.680 
                 0.000 
                 0.003 
                 2.344 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103855 
                 CD276 
                 1.047 
                 6.318 
                 3.006 
                 0.004 
                 0.045 
                 −2.268 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188070 
                 C11orf95 
                 1.047 
                 5.081 
                 3.160 
                 0.003 
                 0.034 
                 −1.861 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000148120 
                 C9orf3 
                 1.047 
                 6.791 
                 4.222 
                 0.000 
                 0.006 
                 0.998 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136379 
                 ABHD17C 
                 1.046 
                 4.956 
                 3.430 
                 0.001 
                 0.022 
                 −1.175 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101255 
                 TRIB3 
                 1.042 
                 4.037 
                 3.178 
                 0.003 
                 0.033 
                 −1.816 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125835 
                 SNRPB 
                 1.041 
                 6.144 
                 4.371 
                 0.000 
                 0.005 
                 1.432 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000183779 
                 ZNF703 
                 1.039 
                 5.083 
                 3.989 
                 0.000 
                 0.008 
                 0.335 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165304 
                 MELK 
                 1.037 
                 4.516 
                 4.038 
                 0.000 
                 0.008 
                 0.498 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000117632 
                 STMN1 
                 1.036 
                 6.544 
                 3.691 
                 0.001 
                 0.013 
                 −0.513 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000010278 
                 CD9 
                 1.034 
                 6.755 
                 3.187 
                 0.003 
                 0.033 
                 −1.832 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000084636 
                 COL16A1 
                 1.029 
                 7.656 
                 2.976 
                 0.005 
                 0.047 
                 −2.360 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000131652 
                 THOC6 
                 1.027 
                 3.900 
                 4.178 
                 0.000 
                 0.006 
                 0.930 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000120327 
                 PCDHB14 
                 1.026 
                 3.064 
                 2.940 
                 0.005 
                 0.049 
                 −2.294 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101220 
                 C200rf27 
                 1.025 
                 4.497 
                 3.913 
                 0.000 
                 0.009 
                 0.173 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000141837 
                 CACNA1A 
                 1.021 
                 5.706 
                 4.020 
                 0.000 
                 0.008 
                 0.441 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000182004 
                 SNRPE 
                 1.020 
                 4.387 
                 3.972 
                 0.000 
                 0.009 
                 0.350 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000083307 
                 GRHL2 
                 1.020 
                 5.924 
                 3.819 
                 0.000 
                 0.011 
                 −0.137 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198720 
                 ANKRD13B 
                 1.019 
                 3.620 
                 3.059 
                 0.004 
                 0 041 
                 −2.064 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104723 
                 TUSC3 
                 1.018 
                 4.719 
                 3.399 
                 0.002 
                 0.023 
                 −1.255 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000095002 
                 MSH2 
                 1.016 
                 5.261 
                 3.607 
                 0.001 
                 0.015 
                 −0.673 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143641 
                 GALNT2 
                 1.012 
                 7.024 
                 5.240 
                 0.000 
                 0.001 
                 4.039 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000167695 
                 FAM57A 
                 1.006 
                 4.784 
                 4.116 
                 0.000 
                 0.007 
                 0.727 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000177045 
                 SIX5 
                 1.005 
                 3.844 
                 3.516 
                 0.001 
                 0.018 
                 −0.862 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000012211 
                 PRICKLE3 
                 1.003 
                 4.021 
                 5.221 
                 0.000 
                 0.001 
                 3.960 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000178078 
                 STAP2 
                 1.003 
                 4.509 
                 2.971 
                 0.005 
                 0.047 
                 −2.263 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000109084 
                 TMEM97 
                 1.001 
                 3.933 
                 3.023 
                 0.004 
                 0.043 
                 −2.134 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188157 
                 AGRN 
                 1.000 
                 8.450 
                 2.975 
                 0.005 
                 0.047 
                 −2.348 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000000460 
                 C1orf112 
                 1.000 
                 4.410 
                 3.589 
                 0.001 
                 0.016 
                 −0.692 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173726 
                 TOMM20 
                 0.999 
                 7.329 
                 5.259 
                 0.000 
                 0.001 
                 4.095 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000070731 
                 ST6GALNAC2 
                 0.999 
                 5.029 
                 3.613 
                 0.001 
                 0.015 
                 −0.671 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000158169 
                 FANCC 
                 0.998 
                 5.521 
                 4.647 
                 0.000 
                 0.003 
                 2.254 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172296 
                 SPTLC3 
                 0.995 
                 5.568 
                 3.273 
                 0.002 
                 0.029 
                 −1.544 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198075 
                 SULT1C4 
                 0.991 
                 2.070 
                 4.056 
                 0.000 
                 0.007 
                 0.597 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000117650 
                 NEK2 
                 0.990 
                 3.955 
                 3.041 
                 0.004 
                 0.042 
                 −2.099 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165434 
                 PGM2L1 
                 0.990 
                 5.364 
                 4.018 
                 0.000 
                 0.008 
                 0.461 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168795 
                 ZBTB5 
                 0.988 
                 5.293 
                 5.873 
                 0.000 
                 0.000 
                 5.993 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125817 
                 CENPB 
                 0.984 
                 6.263 
                 4.742 
                 0.000 
                 0.002 
                 2.530 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000132646 
                 PCNA 
                 0.981 
                 5.329 
                 3.639 
                 0.001 
                 0.015 
                 −0.607 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000069275 
                 NUCKS1 
                 0.979 
                 8.703 
                 3.911 
                 0.000 
                 0.009 
                 0.116 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000139880 
                 CDH24 
                 0.977 
                 3.819 
                 2.949 
                 0.005 
                 0.048 
                 −2.315 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000078900 
                 TP73 
                 0.973 
                 3.972 
                 3.013 
                 0.004 
                 0.044 
                 −2.225 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000122778 
                 KIAA1549 
                 0.965 
                 4.167 
                 4.237 
                 0.000 
                 0.006 
                 1.068 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136636 
                 KCTD3 
                 0.963 
                 6.019 
                 3.990 
                 0.000 
                 0.008 
                 0.342 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000099364 
                 FBXL19 
                 0.962 
                 5.432 
                 3.340 
                 0.002 
                 0.025 
                 −1.379 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000134504 
                 KCTD1 
                 0.961 
                 4.839 
                 4.329 
                 0.000 
                 0.005 
                 1.334 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000179627 
                 ZBTB42 
                 0.961 
                 3.343 
                 3.872 
                 0.000 
                 0.010 
                 0.095 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168758 
                 SEMA4C 
                 0.958 
                 6.018 
                 3.993 
                 0.000 
                 0.008 
                 0.344 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165283 
                 STOML2 
                 0.952 
                 5.125 
                 3.798 
                 0.000 
                 0.011 
                 −0.125 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000181744 
                 C3orf58 
                 0.949 
                 5.562 
                 3.941 
                 0.000 
                 0.009 
                 0.188 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000078246 
                 TULP3 
                 0.944 
                 4.577 
                 3.084 
                 0.004 
                 0.039 
                 −1.978 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165282 
                 PIGO 
                 0.941 
                 5.498 
                 4.044 
                 0.000 
                 0.008 
                 0.539 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000187535 
                 IFT140 
                 0.940 
                 4.575 
                 3.936 
                 0.000 
                 0.009 
                 0.252 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000180611 
                 MB21D2 
                 0.938 
                 3.437 
                 2.987 
                 0.005 
                 0.046 
                 −2.175 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000141198 
                 TOM1L1 
                 0.937 
                 4.264 
                 3.564 
                 0.001 
                 0.017 
                 −0.786 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000006704 
                 GTF2IRD1 
                 0.935 
                 5.604 
                 3.298 
                 0.002 
                 0.027 
                 −1.525 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125901 
                 MRPS26 
                 0.935 
                 4.118 
                 4.429 
                 0.000 
                 0.004 
                 1.635 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137821 
                 LRRC49 
                 0.935 
                 3.597 
                 4.231 
                 0.000 
                 0.006 
                 1.059 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000158470 
                 B4GALT5 
                 0.935 
                 6.323 
                 3.589 
                 0.001 
                 0.016 
                 −0.775 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000071575 
                 TRIB2 
                 0.933 
                 6.350 
                 4.662 
                 0.000 
                 0.003 
                 2.288 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000149639 
                 SOGA1 
                 0.933 
                 7.716 
                 4.408 
                 0.000 
                 0.004 
                 1.532 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000133026 
                 MYH10 
                 0.932 
                 6.900 
                 3.429 
                 0.001 
                 0.022 
                 −1.209 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000083444 
                 PLOD1 
                 0.931 
                 6.368 
                 3.248 
                 0.002 
                 0.030 
                 −1.675 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000021574 
                 SPAST 
                 0.929 
                 5.644 
                 5.797 
                 0.000 
                 0.000 
                 5.757 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000113161 
                 HMGCR 
                 0.929 
                 5.892 
                 3.031 
                 0.004 
                 0.043 
                 −2.189 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143258 
                 USP21 
                 0.929 
                 4.629 
                 5.281 
                 0.000 
                 0.001 
                 4.160 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000118257 
                 NRP2 
                 0.925 
                 6.812 
                 3.093 
                 0.004 
                 0.039 
                 −2.066 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114126 
                 TFDP2 
                 0.925 
                 6.410 
                 4.395 
                 0.000 
                 0.004 
                 1.494 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000116199 
                 FAM20B 
                 0.921 
                 6.664 
                 4.066 
                 0.000 
                 0.007 
                 0.541 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000221829 
                 FANCG 
                 0.921 
                 4.386 
                 4.128 
                 0.000 
                 0.007 
                 0.791 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000086061 
                 DNAJA1 
                 0.918 
                 6.454 
                 2.944 
                 0.005 
                 0.049 
                 −2.410 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000213930 
                 GALT 
                 0.916 
                 4.948 
                 4.020 
                 0.000 
                 0.008 
                 0.484 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000019485 
                 PRDM11 
                 0.915 
                 5.015 
                 3.591 
                 0.001 
                 0.016 
                 −0.754 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000151914 
                 DST 
                 0.915 
                 10.012 
                 3.604 
                 0.001 
                 0.016 
                 −0.713 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114770 
                 ABCC5 
                 0.915 
                 7.369 
                 3.642 
                 0.001 
                 0.015 
                 −0.641 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000167815 
                 PRDX2 
                 0.914 
                 5.114 
                 3.244 
                 0.002 
                 0.030 
                 −1.650 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000179869 
                 ABCA13 
                 0.913 
                 4.705 
                 2.962 
                 0.005 
                 0.047 
                 −2.364 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196189 
                 SEMA4A 
                 0.912 
                 5.880 
                 3.112 
                 0.003 
                 0.038 
                 −2.012 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164970 
                 FAM219A 
                 0.912 
                 5.216 
                 3.544 
                 0.001 
                 0.018 
                 −0.831 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000169925 
                 BRD3 
                 0.911 
                 6.092 
                 4.527 
                 0.000 
                 0.004 
                 1.889 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104835 
                 SARS2 
                 0.909 
                 3.949 
                 3.373 
                 0.002 
                 0.024 
                 −1.256 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000142675 
                 CNKSR1 
                 0.903 
                 4.171 
                 3.043 
                 0.004 
                 0.042 
                 −2.078 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000132623 
                 ANKEF1 
                 0.902 
                 4.365 
                 3.736 
                 0.001 
                 0.012 
                 −0.318 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143149 
                 ALDH9A1 
                 0.900 
                 5.481 
                 4.241 
                 0.000 
                 0.006 
                 1.079 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000105202 
                 FBL 
                 0.898 
                 6.110 
                 3.104 
                 0.003 
                 0.038 
                 −2.034 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000133619 
                 KRBA1 
                 0.897 
                 4.606 
                 2.967 
                 0.005 
                 0.047 
                 −2.291 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000155755 
                 TMEM237 
                 0.896 
                 4.856 
                 3.660 
                 0.001 
                 0.014 
                 −0.529 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000186522 
                 SEPT10 
                 0.890 
                 6.367 
                 3.058 
                 0.004 
                 0.041 
                 −2.115 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000187164 
                 SHTN1 
                 0.889 
                 5.622 
                 3.231 
                 0.002 
                 0.031 
                 −1.643 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101856 
                 PGRMC1 
                 0.889 
                 5.770 
                 4.379 
                 0.000 
                 0.005 
                 1.467 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000158467 
                 AHCYL2 
                 0.888 
                 5.108 
                 3.019 
                 0.004 
                 0.044 
                 −2.142 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000204536 
                 CCHCR1 
                 0.886 
                 4.520 
                 3.427 
                 0.001 
                 0.022 
                 −1.122 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000205476 
                 CCDC85C 
                 0.885 
                 6.726 
                 3.693 
                 0.00) 
                 0.013 
                 −0.467 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143321 
                 HDGF 
                 0.882 
                 7.794 
                 4.009 
                 0.000 
                 0.008 
                 0.375 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000122378 
                 FAM213A 
                 0.881 
                 6.102 
                 2.934 
                 0.005 
                 0.049 
                 −2.417 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162714 
                 ZNF496 
                 0.881 
                 6.216 
                 3.728 
                 0.001 
                 0.013 
                 −0.405 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000106367 
                 AP1S1 
                 0.880 
                 4.473 
                 3.720 
                 0.001 
                 0.013 
                 −0.332 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196391 
                 ZNF774 
                 0.877 
                 3.976 
                 3.910 
                 0.000 
                 0.009 
                 0.161 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197077 
                 KIAA1671 
                 0.876 
                 7.340 
                 3.047 
                 0.004 
                 0.042 
                 −2.177 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168275 
                 COA6 
                 0.876 
                 3.290 
                 3.176 
                 0.003 
                 0.033 
                 −1.694 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000151748 
                 SAV1 
                 0.875 
                 5.495 
                 3.616 
                 0.001 
                 0.015 
                 −0.647 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000070018 
                 LRP6 
                 0.875 
                 6.056 
                 3.829 
                 0.000 
                 0.011 
                 −0.127 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000147874 
                 HAUS6 
                 0.875 
                 5.794 
                 3.480 
                 0.001 
                 0.020 
                 −1.021 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138336 
                 TET1 
                 0.870 
                 3.684 
                 3.326 
                 0.002 
                 0.026 
                 −1.371 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000183814 
                 LIN9 
                 0.870 
                 3.205 
                 3.288 
                 0.002 
                 0.028 
                 −1.444 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125484 
                 GTF3C4 
                 0.867 
                 6.463 
                 5.010 
                 0.000 
                 0.002 
                 3.335 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000175768 
                 TOMM5 
                 0.866 
                 5.007 
                 3.954 
                 0.000 
                 0.009 
                 0.273 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000074800 
                 ENO1 
                 0.866 
                 9.193 
                 3.009 
                 0.004 
                 0.045 
                 −2.268 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000176463 
                 SLCO3A1 
                 0.863 
                 5.862 
                 3.295 
                 0.002 
                 0.027 
                 −1.551 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000147650 
                 LRP12 
                 0.861 
                 5.335 
                 2.999 
                 0.005 
                 0.045 
                 −2.267 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196230 
                 TUBB 
                 0.861 
                 9.131 
                 3.965 
                 0.000 
                 0.009 
                 0.266 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125868 
                 DSTN 
                 0.860 
                 7.368 
                 3.188 
                 0.003 
                 0.033 
                 −1.818 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173207 
                 CKS1B 
                 0.860 
                 4.649 
                 3.367 
                 0.002 
                 0.024 
                 −1.284 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000108679 
                 LGALS3BP 
                 0.856 
                 7.639 
                 3.032 
                 0.004 
                 0.043 
                 −2.225 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000144320 
                 KIAA1715 
                 0.856 
                 6.146 
                 3.296 
                 0.002 
                 0.027 
                 −1.513 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000000003 
                 TSPAN6 
                 0.856 
                 4.498 
                 3.269 
                 0.002 
                 0.029 
                 −1.539 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143499 
                 SMYD2 
                 0.855 
                 5.652 
                 3.583 
                 0.001 
                 0.016 
                 −0.755 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000088930 
                 XRN2 
                 0.855 
                 6.663 
                 4.975 
                 0.000 
                 0.002 
                 3.234 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135205 
                 CCDC146 
                 0.854 
                 3.642 
                 2.995 
                 0.005 
                 0.045 
                 −2.170 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136944 
                 LMX1B 
                 0.854 
                 3.197 
                 3.197 
                 0.003 
                 0.033 
                 −1.695 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162851 
                 TFB2M 
                 0.853 
                 3.247 
                 3.857 
                 0.000 
                 0.010 
                 0.047 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000204308 
                 RNF5 
                 0.849 
                 4.156 
                 4.359 
                 0.000 
                 0.005 
                 1.442 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000124098 
                 FAM210B 
                 0.848 
                 5.772 
                 3.381 
                 0.002 
                 0.024 
                 −1.327 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000050327 
                 ARHGEF5 
                 0.842 
                 5.829 
                 3.202 
                 0.003 
                 0.032 
                 −1.741 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101003 
                 GINS1 
                 0.842 
                 4.851 
                 3.000 
                 0.005 
                 0.045 
                 −2.222 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000108468 
                 CBX1 
                 0.841 
                 5.661 
                 4.507 
                 0.000 
                 0.004 
                 1.837 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165997 
                 ARL5B 
                 0.840 
                 6.324 
                 3.774 
                 0.001 
                 0.012 
                 −0.258 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100300 
                 TSPO 
                 0.838 
                 5.203 
                 3.840 
                 0.000 
                 0.010 
                 −0.044 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000119669 
                 IRF2BPL 
                 0.836 
                 5.943 
                 4.804 
                 0.000 
                 0.002 
                 2.726 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197562 
                 RAB40C 
                 0.832 
                 4.749 
                 3.263 
                 0.002 
                 0.029 
                 −1.548 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143256 
                 PFDN2 
                 0.831 
                 3.485 
                 3.085 
                 0.004 
                 0.039 
                 −1.943 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000182704 
                 TSKU 
                 0.830 
                 6.606 
                 3.201 
                 0.003 
                 0.032 
                 −1.765 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000171262 
                 FAM98B 
                 0.827 
                 5.614 
                 4.175 
                 0.000 
                 0.006 
                 0.873 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000157216 
                 SSBP3 
                 0.827 
                 5.661 
                 4.079 
                 0.000 
                 0.007 
                 0.593 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000187607 
                 ZNF286A 
                 0.827 
                 4.927 
                 3.443 
                 0.001 
                 0.021 
                 −1.130 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000089050 
                 RBBP9 
                 0.825 
                 5.026 
                 3.070 
                 0.004 
                 0.040 
                 −2.045 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000149925 
                 ALDOA 
                 0.818 
                 8.684 
                 2.962 
                 0.005 
                 0.047 
                 −2.393 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164877 
                 MICALL2 
                 0.818 
                 6.519 
                 3.036 
                 0.004 
                 0.043 
                 −2.194 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000005156 
                 LIG3 
                 0.817 
                 6.498 
                 4.450 
                 0.000 
                 0.004 
                 1.662 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114054 
                 PCCB 
                 0.813 
                 4.891 
                 3.729 
                 0.001 
                 0.013 
                 −0.356 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000105135 
                 ILVBL 
                 0.813 
                 5.015 
                 3.852 
                 0.000 
                 0.010 
                 −0.008 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000017260 
                 ATP2C1 
                 0.810 
                 7.598 
                 3.933 
                 0.000 
                 0.009 
                 0.161 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168264 
                 IRF2BP2 
                 0.805 
                 7.766 
                 4.182 
                 0.000 
                 0.006 
                 0.872 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000074696 
                 HACD3 
                 0.805 
                 6.575 
                 4.137 
                 0.000 
                 0.007 
                 0.744 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100246 
                 DNAL4 
                 0.804 
                 3.194 
                 3.868 
                 0.000 
                 0.010 
                 0.070 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000127586 
                 CHTF18 
                 0.804 
                 5.099 
                 2.972 
                 0.005 
                 0.047 
                 −2.310 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000116212 
                 LRRC42 
                 0.802 
                 4.193 
                 2.992 
                 0.005 
                 0.045 
                 −2.185 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000122705 
                 CLTA 
                 0.802 
                 6.008 
                 4.513 
                 0.000 
                 0.004 
                 1.854 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125534 
                 PPDPF 
                 0.801 
                 6.403 
                 4.586 
                 0.000 
                 0.003 
                 2.062 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000177868 
                 SVBP 
                 0.800 
                 2.388 
                 3.312 
                 0.002 
                 0.026 
                 −1.360 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000132661 
                 NXT1 
                 0.799 
                 3.265 
                 3.251 
                 0.002 
                 0.029 
                 −1.520 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000147400 
                 CETN2 
                 0.799 
                 3.789 
                 3.802 
                 0.000 
                 0.011 
                 −0.107 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000152990 
                 ADGRA3 
                 0.797 
                 5.417 
                 3.258 
                 0.002 
                 0.029 
                 −1.600 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000184897 
                 H1FX 
                 0.796 
                 6.281 
                 4.122 
                 0.000 
                 0.007 
                 0.706 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000183828 
                 NUDT14 
                 0.792 
                 3.562 
                 2.973 
                 0.005 
                 0.047 
                 −2.195 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160767 
                 FAM189B 
                 0.791 
                 4.980 
                 3.360 
                 0.002 
                 0.024 
                 −1.321 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162585 
                 FAAP20 
                 0.788 
                 5.537 
                 3.569 
                 0.001 
                 0.017 
                 −0.814 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162885 
                 B3GALNT2 
                 0.788 
                 5.346 
                 4.444 
                 0.000 
                 0.004 
                 1.654 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160271 
                 RALGDS 
                 0.787 
                 7.165 
                 3.133 
                 0.003 
                 0.036 
                 −1.969 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164758 
                 MED30 
                 0.787 
                 2.905 
                 3.551 
                 0.001 
                 0.017 
                 −0.757 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000179958 
                 DCTPP1 
                 0.786 
                 3.897 
                 3.209 
                 0.003 
                 0.032 
                 −1.659 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000180992 
                 MRPL14 
                 0.784 
                 3.808 
                 3.266 
                 0.002 
                 0.029 
                 −1.504 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000240849 
                 TMEM189 
                 0.784 
                 6.643 
                 3.660 
                 0.001 
                 0.014 
                 −0.588 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114125 
                 RNF7 
                 0.783 
                 5.600 
                 4.150 
                 0.000 
                 0.006 
                 0.794 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000131116 
                 ZNF428 
                 0.782 
                 3.732 
                 3.096 
                 0.004 
                 0.039 
                 −1.934 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000139350 
                 NEDD1 
                 0.781 
                 5.453 
                 2.948 
                 0.005 
                 0.048 
                 −2.353 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000109113 
                 RAB34 
                 0.781 
                 4.980 
                 3.186 
                 0.003 
                 0.033 
                 −1.779 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198876 
                 DCAF12 
                 0.780 
                 6.113 
                 4.194 
                 0.000 
                 0.006 
                 0.923 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163041 
                 H3F3A 
                 0.775 
                 7.837 
                 5.038 
                 0.000 
                 0.002 
                 3.420 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000088854 
                 C20orf194 
                 0.773 
                 5.956 
                 3.040 
                 0.004 
                 0.042 
                 −2.131 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185630 
                 PBX1 
                 0.772 
                 6.170 
                 3.221 
                 0.002 
                 0.031 
                 −1.751 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000020256 
                 ZFP64 
                 0.772 
                 5.005 
                 3.875 
                 0.000 
                 0.010 
                 0.025 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000178163 
                 ZNF518B 
                 0.770 
                 5.931 
                 3.123 
                 0.003 
                 0.037 
                 −1.977 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000177383 
                 MAGEF1 
                 0.768 
                 4.429 
                 4.251 
                 0.000 
                 0.006 
                 1.113 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137124 
                 ALDH1B1 
                 0.767 
                 4.475 
                 3.017 
                 0.004 
                 0.044 
                 −2.172 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114988 
                 LMAN2L 
                 0.766 
                 3.777 
                 3.357 
                 0.002 
                 0.025 
                 −1.266 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188229 
                 TUBB4B 
                 0.763 
                 7.150 
                 3.047 
                 0.004 
                 0.042 
                 −2.184 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137074 
                 APTX 
                 0.763 
                 4.734 
                 3.090 
                 0.004 
                 0.039 
                 −1.961 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125652 
                 ALKBH7 
                 0.762 
                 3.115 
                 3.000 
                 0.005 
                 0.045 
                 −2.117 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163382 
                 NAXE 
                 0.760 
                 4.573 
                 4.537 
                 0.000 
                 0.004 
                 1.950 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000081692 
                 JMJD4 
                 0.758 
                 4.762 
                 3.772 
                 0.001 
                 0.012 
                 −0.234 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143553 
                 SNAPIN 
                 0.756 
                 3.833 
                 3.863 
                 0.000 
                 0.010 
                 0.062 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143493 
                 INTS7 
                 0.754 
                 5.317 
                 3.255 
                 0.002 
                 0.029 
                 −1.602 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000175130 
                 MARCKSL1 
                 0.754 
                 6.052 
                 3.103 
                 0.003 
                 0.038 
                 −2.036 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143368 
                 SF3B4 
                 0.753 
                 5.240 
                 3.612 
                 0.001 
                 0.015 
                 −0.650 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000018408 
                 WWTR1 
                 0.752 
                 6.583 
                 3.011 
                 0.004 
                 0.044 
                 −2.266 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136522 
                 MRPL47 
                 0.752 
                 4.389 
                 3.483 
                 0.001 
                 0.020 
                 −0.990 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165804 
                 ZNF219 
                 0.751 
                 4.798 
                 3.698 
                 0.001 
                 0.013 
                 −0.414 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168778 
                 TCTN2 
                 0.750 
                 4.447 
                 3.180 
                 0.003 
                 0.033 
                 −1.759 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000059573 
                 ALDH18A1 
                 0.746 
                 5.726 
                 3.884 
                 0.000 
                 0.010 
                 0.068 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000107779 
                 BMPR1A 
                 0.746 
                 5.699 
                 3.864 
                 0.000 
                 0.010 
                 0.012 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103404 
                 USP31 
                 0.744 
                 6.813 
                 3.130 
                 0.003 
                 0.037 
                 −1.968 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196418 
                 ZNF124 
                 0.742 
                 5.095 
                 4.080 
                 0.000 
                 0.007 
                 0.609 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000007047 
                 MARK4 
                 0.742 
                 5.703 
                 3.981 
                 0.000 
                 0.008 
                 0.314 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000154640 
                 BTG3 
                 0.742 
                 4.568 
                 3.037 
                 0.004 
                 0.043 
                 −2.154 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143578 
                 CREB3L4 
                 0.741 
                 2.904 
                 2.944 
                 0.005 
                 0.049 
                 −2.254 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000139197 
                 PEX5 
                 0.740 
                 5.241 
                 4.082 
                 0.000 
                 0.007 
                 0.608 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000121989 
                 ACVR2A 
                 0.738 
                 4.973 
                 2.952 
                 0.005 
                 0.048 
                 −2.321 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000126432 
                 PRDX5 
                 0.736 
                 5.608 
                 3.431 
                 0.001 
                 0.022 
                 −1.120 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000157985 
                 AGAP1 
                 0.735 
                 5.617 
                 3.288 
                 0.002 
                 0.028 
                 −1.562 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143742 
                 SRP9 
                 0.733 
                 7.103 
                 4.334 
                 0.000 
                 0.005 
                 1.312 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000112144 
                 ICK 
                 0.731 
                 5.453 
                 3.330 
                 0.002 
                 0.026 
                 −1.433 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000111845 
                 PAK1IP1 
                 0.730 
                 3.610 
                 3.454 
                 0.001 
                 0.021 
                 −1.037 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000089091 
                 DZANK1 
                 0.730 
                 3.535 
                 2.949 
                 0.005 
                 0.048 
                 −2.266 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163964 
                 PIGX 
                 0.729 
                 4.982 
                 3.492 
                 0.001 
                 0.019 
                 −1.009 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164663 
                 USP49 
                 0.726 
                 5.208 
                 3.067 
                 0.004 
                 0.041 
                 −2.072 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000113300 
                 CNOT6 
                 0.725 
                 6.466 
                 3.954 
                 0.000 
                 0.009 
                 0.252 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000178409 
                 BEND3 
                 0.725 
                 3.802 
                 3.324 
                 0.002 
                 0.026 
                 −1.373 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000158623 
                 COPG2 
                 0.720 
                 4.713 
                 4.136 
                 0.000 
                 0.007 
                 0.796 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130382 
                 MLLT1 
                 0.716 
                 6.107 
                 3.300 
                 0.002 
                 0.027 
                 −1.539 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137166 
                 FOXP4 
                 0.716 
                 5.508 
                 3.343 
                 0.002 
                 0.025 
                 −1.418 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000067704 
                 IARS2 
                 0.715 
                 6.373 
                 3.429 
                 0.001 
                 0.022 
                 −1.181 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000256349 
                 CTD- 
                 0.710 
                 2.593 
                 3.065 
                 0.004 
                 0.041 
                 −1.970 
               
               
                   
                   
                 307407.11 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135912 
                 TILL4 
                 0.709 
                 5.416 
                 3.462 
                 0.001 
                 0.020 
                 −1.087 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163918 
                 RFC4 
                 0.708 
                 4.149 
                 3.376 
                 0.002 
                 0.024 
                 −1.264 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000161996 
                 WDR90 
                 0.705 
                 6.119 
                 4.221 
                 0.000 
                 0.006 
                 0.996 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000099800 
                 TIMM13 
                 0.702 
                 4.664 
                 3.349 
                 0.002 
                 0.025 
                 −1.339 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000116586 
                 LAMTOR2 
                 0.701 
                 3.476 
                 3.198 
                 0.003 
                 0.033 
                 −1.643 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137804 
                 NUSAP1 
                 0.700 
                 5.405 
                 2.942 
                 0.005 
                 0.049 
                 −2.398 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101266 
                 CSNK2A1 
                 0.699 
                 7.014 
                 4.716 
                 0.000 
                 0.003 
                 2.445 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000120008 
                 WDR11 
                 0.696 
                 6.829 
                 3.826 
                 0.000 
                 0.011 
                 −0.124 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000247315 
                 ZCCHC3 
                 0.696 
                 4.571 
                 4.172 
                 0.000 
                 0.006 
                 0.891 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163785 
                 RYK 
                 0.694 
                 6.706 
                 4.063 
                 0.000 
                 0.007 
                 0.530 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143621 
                 ILF2 
                 0.694 
                 6.366 
                 4.682 
                 0.000 
                 0.003 
                 2.350 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000132694 
                 ARHGEF11 
                 0.692 
                 6.513 
                 3.174 
                 0.003 
                 0.033 
                 −1.851 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168118 
                 RAB4A 
                 0.692 
                 5.048 
                 3.103 
                 0.003 
                 0.038 
                 −1.976 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135778 
                 NTPCR 
                 0.690 
                 5.737 
                 3.895 
                 0.000 
                 0.009 
                 0.106 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000228300 
                 C19orf24 
                 0.688 
                 3.645 
                 3.400 
                 0.001 
                 0.023 
                 −1.181 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000176396 
                 EID2 
                 0.687 
                 2.944 
                 2.950 
                 0.005 
                 0.048 
                 −2.222 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000124688 
                 MAD2L1BP 
                 0.687 
                 3.675 
                 3.545 
                 0.001 
                 0.017 
                 −0.785 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138175 
                 ARL3 
                 0.687 
                 3.153 
                 3.474 
                 0.001 
                 0.020 
                 −0.957 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000089123 
                 TASP1 
                 0.687 
                 4.290 
                 3.305 
                 0.002 
                 0.027 
                 −1.432 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000141994 
                 DUS3L 
                 0.686 
                 4.327 
                 3.114 
                 0.003 
                 0.038 
                 −1.927 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138002 
                 IFT172 
                 0.685 
                 4.913 
                 3.392 
                 0.002 
                 0.023 
                 −1.246 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185236 
                 RAB11B 
                 0.685 
                 5.473 
                 3.382 
                 0.002 
                 0.023 
                 −1.285 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125779 
                 PANK2 
                 0.685 
                 6.065 
                 4.595 
                 0.000 
                 0.003 
                 2.096 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000099810 
                 MTAP 
                 0.683 
                 6.736 
                 3.022 
                 0.004 
                 0.043 
                 −2.205 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114491 
                 UMPS 
                 0.679 
                 5.786 
                 2.989 
                 0.005 
                 0.046 
                 −2.304  
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000118007 
                 STAG1 
                 0.679 
                 6.758 
                 4.741 
                 0.000 
                 0.002 
                 2.520 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164889 
                 SLC4A2 
                 0.678 
                 6.030 
                 3.400 
                 0.001 
                 0.023 
                 −1.264 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000180891 
                 CUEDC1 
                 0.678 
                 4.969 
                 3.209 
                 0.003 
                 0.032 
                 −1.742 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163655 
                 GMPS 
                 0.675 
                 6.928 
                 4.226 
                 0.000 
                 0.006 
                 0.999 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125834 
                 STK35 
                 0.674 
                 6.495 
                 3.780 
                 0.000 
                 0.012 
                 −0.264 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137054 
                 POLR1E 
                 0.673 
                 4.192 
                 3.264 
                 0.002 
                 0.029 
                 −1.547 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114107 
                 CEP70 
                 0.673 
                 4.401 
                 3.024 
                 0.004 
                 0.043 
                 −2.195 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000035687 
                 ADSS 
                 0.672 
                 6.078 
                 4.481 
                 0.000 
                 0.004 
                 1.749 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197345 
                 MRPL21 
                 0.672 
                 4.513 
                 3.690 
                 0.001 
                 0.013 
                 −0.472 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143436 
                 MRPL9 
                 0.671 
                 4.477 
                 3.463 
                 0.001 
                 0.020 
                 −1.021 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000132475 
                 H3F3B 
                 0.671 
                 8.660 
                 3.743 
                 0.001 
                 0.012 
                 −0.360 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000073803 
                 MAP3K13 
                 0.669 
                 5.921 
                 3.324 
                 0.002 
                 0.026 
                 −1.467 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000265241 
                 RBM8A 
                 0.668 
                 6.502 
                 3.609 
                 0.001 
                 0.015 
                 −0.720 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000124702 
                 KLHDC3 
                 0.666 
                 5.308 
                 4.516 
                 0.000 
                 0.004 
                 1.877 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000170604 
                 IRF2BP1 
                 0.665 
                 4.024 
                 3.159 
                 0.003 
                 0.034 
                 −1.798 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000116957 
                 TBCE 
                 0.664 
                 4.423 
                 4.275 
                 0.000 
                 0.006 
                 1.194 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000146858 
                 ZC3HAV1L 
                 0.663 
                 3.965 
                 3.392 
                 0.002 
                 0.023 
                 −1.208 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000127616 
                 SMARCA4 
                 0.663 
                 7.453 
                 3.619 
                 0.001 
                 0.015 
                 −0.708 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000133422 
                 MORC2 
                 0.663 
                 6.613 
                 3.277 
                 0.002 
                 0.028 
                 −1.606 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125898 
                 FAM110A 
                 0.662 
                 4.268 
                 3.031 
                 0.004 
                 0.043 
                 −2.090 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000140391 
                 TSPAN3 
                 0.661 
                 6.447 
                 3.407 
                 0.001 
                 0.022 
                 −1.257 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125743 
                 SNRPD2 
                 0.661 
                 5.122 
                 3.727 
                 0.001 
                 0.013 
                 −0.359 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000145284 
                 SCD5 
                 0.658 
                 5.856 
                 3.792 
                 0.000 
                 0.011 
                 −0.212 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101343 
                 CRNKL1 
                 0.656 
                 5.166 
                 3.195 
                 0.003 
                 0.033 
                 −1.735 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000159217 
                 IGF2BP1 
                 0.656 
                 4.207 
                 3.287 
                 0.002 
                 0.028 
                 −1.508 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000152904 
                 GGPS1 
                 0.655 
                 4.946 
                 4.303 
                 0.000 
                 0.005 
                 1.261 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163913 
                 IFT122 
                 0.654 
                 5.199 
                 3.414 
                 0.001 
                 0.022 
                 −1.214 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000161202 
                 DVL3 
                 0.654 
                 7.184 
                 3.194 
                 0.003 
                 0.033 
                 −1.818 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000096384 
                 HSP90AB1 
                 0.653 
                 8.939 
                 2.983 
                 0.005 
                 0.046 
                 −2.326 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101365 
                 IDH3B 
                 0.652 
                 5.333 
                 3.337 
                 0.002 
                 0.026 
                 −1.383 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197965 
                 MPZL1 
                 0.652 
                 7.263 
                 3.587 
                 0.001 
                 0.016 
                 −0.776 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000107341 
                 UBE2R2 
                 0.652 
                 6.362 
                 3.104 
                 0.003 
                 0.038 
                 −1.997 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000107175 
                 CREB3 
                 0.651 
                 4.283 
                 4.051 
                 0.000 
                 0.007 
                 0.570 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000167635 
                 ZNF146 
                 0.651 
                 6.698 
                 4.055 
                 0.000 
                 0.007 
                 0.510 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000186350 
                 RXRA 
                 0.649 
                 7.402 
                 3.093 
                 0.004 
                 0.039 
                 −2.067 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188060 
                 RAB42 
                 0.649 
                 2.828 
                 3.043 
                 0.004 
                 0.042 
                 −2.014 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000167645 
                 YIF1B 
                 0.647 
                 4.481 
                 3.338 
                 0.002 
                 0.026 
                 −1.332 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000182768 
                 NGRN 
                 0.647 
                 6.656 
                 4.267 
                 0.000 
                 0.006 
                 1.121 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198700 
                 IPO9 
                 0.646 
                 7.147 
                 4.008 
                 0.000 
                 0.008 
                 0.372 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125870 
                 SNRPB2 
                 0.645 
                 4.436 
                 3.522 
                 0.001 
                 0.018 
                 −0.848 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000112658 
                 SRF 
                 0.645 
                 5.868 
                 3.106 
                 0.003 
                 0.038 
                 −2.015 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103495 
                 MAZ 
                 0.644 
                 6.950 
                 3.334 
                 0.002 
                 0.026 
                 −1.455 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137404 
                 NRM 
                 0.641 
                 3.816 
                 2.939 
                 0.005 
                 0.049 
                 −2.283 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160783 
                 PMF1 
                 0.641 
                 4.635 
                 3.295 
                 0.002 
                 0.027 
                 −1.475 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000124535 
                 WRNIP1 
                 0.639 
                 5.399 
                 3.693 
                 0.001 
                 0.013 
                 −0.471 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000257315 
                 ZBED6 
                 0.637 
                 6.880 
                 4.910 
                 0.000 
                 0.002 
                 3.033 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143363 
                 PRUNE1 
                 0.636 
                 4.453 
                 3.179 
                 0.003 
                 0.033 
                 −1.741 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000106400 
                 ZNHIT1 
                 0.635 
                 5.825 
                 3.526 
                 0.001 
                 0.018 
                 −0.894 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000001167 
                 NFYA 
                 0.633 
                 5.384 
                 3.341 
                 0.002 
                 0.025 
                 −1.404 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165688 
                 PMPCA 
                 0.632 
                 5.693 
                 4.136 
                 0.000 
                 0.007 
                 0.777 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165006 
                 UBAP1 
                 0.628 
                 5.933 
                 3.020 
                 0.004 
                 0.044 
                 −2.201 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000117625 
                 RCOR3 
                 0.626 
                 6.259 
                 3.912 
                 0.000 
                 0.009 
                 0.121 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103222 
                 ABCC1 
                 0.622 
                 7.732 
                 3.386 
                 0.002 
                 0.023 
                 −1.327 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125877 
                 ITPA 
                 0.621 
                 4.880 
                 3.087 
                 0.004 
                 0.039 
                 −1.994 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173950 
                 XXYLT1 
                 0.620 
                 4.459 
                 3.300 
                 0.002 
                 0.027 
                 −1.499 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160679 
                 CHTOP 
                 0.620 
                 6.573 
                 4.688 
                 0.000 
                 0.003 
                 2.366 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000182095 
                 TNRC18 
                 0.619 
                 8.200 
                 3.013 
                 0.004 
                 0.044 
                 −2.260 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160752 
                 FDPS 
                 0.619 
                 5.958 
                 3.711 
                 0.001 
                 0.013 
                 −0.449 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000089048 
                 ESF1 
                 0.618 
                 4.713 
                 3.372 
                 0.002 
                 0.024 
                 −1.297 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000108953 
                 YWHAE 
                 0.618 
                 7.797 
                 3.124 
                 0.003 
                 0.037 
                 −1.997 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000139146 
                 FAM60A 
                 0.618 
                 6.427 
                 3.262 
                 0.002 
                 0.029 
                 −1.647 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000158850 
                 B4GALT3 
                 0.617 
                 5.147 
                 3.479 
                 0.001 
                 0.020 
                 −0.996 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000071564 
                 TCF3 
                 0.616 
                 6.617 
                 3.050 
                 0.004 
                 0.042 
                 −2.179 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185019 
                 UBOX5 
                 0.616 
                 4.656 
                 2.965 
                 0.005 
                 0.047 
                 −2.290 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000257365 
                 FNTB 
                 0.615 
                 4.412 
                 3.024 
                 0.004 
                 0.043 
                 −2.100 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000224531 
                 SMIM13 
                 0.615 
                 4.666 
                 3.116 
                 0.003 
                 0.037 
                 −1.951 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166886 
                 NAB2 
                 0.612 
                 5.117 
                 2.998 
                 0.005 
                 0.045 
                 −2.242 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000206053 
                 HN1L 
                 0.612 
                 6.640 
                 2.958 
                 0.005 
                 0.048 
                 −2.380 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000123684 
                 LPGAT1 
                 0.607 
                 6.922 
                 3.076 
                 0.004 
                 0.040 
                 −2.106 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143420 
                 ENSA 
                 0.606 
                 7.312 
                 3.972 
                 0.000 
                 0.009 
                 0.271 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143514 
                 TP53BP2 
                 0.606 
                 6.103 
                 3.143 
                 0.003 
                 0.036 
                 −1.926 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000171453 
                 POLR1C 
                 0.604 
                 4.271 
                 3.180 
                 0.003 
                 0.033 
                 −1.756 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188739 
                 RBM34 
                 0.602 
                 5.226 
                 3.984 
                 0.000 
                 0.008 
                 0.336 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000215251 
                 FASTKD5 
                 0.602 
                 4.543 
                 3.925 
                 0.000 
                 0.009 
                 0.200 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160803 
                 UBQLN4 
                 0.598 
                 5.632 
                 3.127 
                 0.003 
                 0.037 
                 −1.951 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101247 
                 NDUFAF5 
                 0.598 
                 4.775 
                 3.040 
                 0.004 
                 0.042 
                 −2.108 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG0OO00163479 
                 SSR2 
                 0.597 
                 6.584 
                 3.092 
                 0.004 
                 0.039 
                 −2.050 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197557 
                 TTC30A 
                 0.595 
                 3.055 
                 3.101 
                 0.003 
                 0.038 
                 −1.917 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000107874 
                 CUEDC2 
                 0.593 
                 3.648 
                 3.120 
                 0.003 
                 0.037 
                 −1.843 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198171 
                 DDRGK1 
                 0.593 
                 4.677 
                 3.082 
                 0.004 
                 0.040 
                 −2.028 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173597 
                 SULT1B1 
                 0.591 
                 8.530 
                 2.975 
                 0.005 
                 0.047 
                 −2.361 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101474 
                 APMAP 
                 0.590 
                 5.991 
                 3.675 
                 0.001 
                 0.014 
                 −0.520 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163781 
                 TOPBP1 
                 0.590 
                 6.540 
                 3.919 
                 0.000 
                 0.009 
                 0.124 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166508 
                 MCM7 
                 0.590 
                 6.696 
                 3.039 
                 0.004 
                 0.043 
                 −2.205 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130402 
                 ACTN4 
                 0.590 
                 8.608 
                 2.968 
                 0.005 
                 0.047 
                 −2.371 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166415 
                 WDR72 
                 0.589 
                 5.022 
                 3.400 
                 0.001 
                 0.023 
                 −1.245 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000121057 
                 AKAP1 
                 0.589 
                 5.606 
                 3.212 
                 0.003 
                 0.032 
                 −1.747 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000065518 
                 NDUFB4 
                 0.589 
                 5.097 
                 2.974 
                 0.005 
                 0.047 
                 −2.276 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000004975 
                 DVL2 
                 0.588 
                 5.471 
                 3.443 
                 0.001 
                 0.021 
                 −1.134 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000006756 
                 ARSD 
                 0.588 
                 5.304 
                 3.865 
                 0.000 
                 0.010 
                 0.020 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163608 
                 NEPRO 
                 0.586 
                 6.122 
                 3.991 
                 0.000 
                 0.008 
                 0.348 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000161091 
                 MFSD12 
                 −0.586 
                 6.190 
                 −3.053 
                 0.004 
                 0.041 
                 −2.121 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166479 
                 TMX3 
                 −0.588 
                 6.159 
                 −3.148 
                 0.003 
                 0.035 
                 −1.917 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000144468 
                 RHBDD1 
                 −0.588 
                 5.581 
                 −3.980 
                 0.000 
                 0.008 
                 0.337 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000144746 
                 ARL6IP5 
                 −0.590 
                 5.907 
                 −2.959 
                 0.005 
                 0.047 
                 −2.294 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000144559 
                 TAMM41 
                 −0.595 
                 4.598 
                 −3.154 
                 0.003 
                 0.035 
                 −1.789 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000102699 
                 PARP4 
                 −0.596 
                 6.816 
                 −2.998 
                 0.005 
                 0.045 
                 −2.274 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000109771 
                 LRP2BP 
                 −0.596 
                 4.248 
                 −3.091 
                 0.004 
                 0.039 
                 −1.937 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000215883 
                 CYB5RL 
                 −0.597 
                 5.013 
                 −2.983 
                 0.005 
                 0.046 
                 −2.273 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101473 
                 ACOT8 
                 −0.598 
                 4.405 
                 −3.112 
                 0.003 
                 0.038 
                 −1.888 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000159720 
                 ATP6VOD1 
                 −0.598 
                 6.186 
                 −3.481 
                 0.001 
                 0.020 
                 −1.016 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000132600 
                 PRMT7 
                 −0.599 
                 5.270 
                 −3.068 
                 0.004 
                 0.041 
                 −2.041 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000127311 
                 HELB 
                 −0.599 
                 6.692 
                 −3.179 
                 0.003 
                 0.033 
                 −1.845 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103043 
                 VAC14 
                 −0.602 
                 6.196 
                 −3.979 
                 0.000 
                 0.008 
                 0.329 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000004534 
                 RBM6 
                 −0.605 
                 7.094 
                 −3.988 
                 0.000 
                 0.008 
                 0.316 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000110344 
                 UBE4A 
                 −0.606 
                 6.667 
                 −4.211 
                 0.000 
                 0.006 
                 0.977 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000118058 
                 KMT2A 
                 −0.607 
                 8.255 
                 −4.667 
                 0.000 
                 0.003 
                 2.296 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198252 
                 STYX 
                 −0.608 
                 6.039 
                 −3.181 
                 0.003 
                 0.033 
                 −1.799 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160799 
                 CCDC12 
                 −0.610 
                 4.311 
                 −3.619 
                 0.001 
                 0.015 
                 −0.600 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000184470 
                 TXNRD2 
                 −0.612 
                 4.944 
                 −3.218 
                 0.002 
                 0.031 
                 −1.664 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000099949 
                 LZTR1 
                 −0.614 
                 6.255 
                 −3.744 
                 0.001 
                 0.012 
                 −0.326 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000204923 
                 FBXO48 
                 −0.615 
                 3.727 
                 −3.812 
                 0.000 
                 0.011 
                 −0.075 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000156990 
                 RPUSD3 
                 −0.615 
                 4.639 
                 −3.700 
                 0.001 
                 0.013 
                 −0.398 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000078814 
                 MYH7B 
                 −0.615 
                 4.119 
                 −2.951 
                 0.005 
                 0.048 
                 −2.305 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165526 
                 RPUSD4 
                 −0.616 
                 4.739 
                 −3.153 
                 0.003 
                 0.035 
                 −1.817 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000072135 
                 PTPN18 
                 −0.617 
                 6.126 
                 −3.455 
                 0.001 
                 0.021 
                 −1.107 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100150 
                 DEPDC5 
                 −0.619 
                 5.375 
                 −3.145 
                 0.003 
                 0.035 
                 −1.865 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000142188 
                 TMEM50B 
                 −0.620 
                 5.099 
                 −3.422 
                 0.001 
                 0.022 
                 −1.137 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000144791 
                 LIMD1 
                 −0.622 
                 6.887 
                 −3.009 
                 0.004 
                 0.044 
                 −2.271 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000140829 
                 DHX38 
                 −0.625 
                 6.096 
                 −4.218 
                 0.000 
                 0.006 
                 1.004 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163867 
                 ZMYM6 
                 −0.626 
                 5.872 
                 −3.910 
                 0.000 
                 0.009 
                 0.133 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000141337 
                 ARSG 
                 −0.626 
                 4.784 
                 −3.314 
                 0.002 
                 0.026 
                 −1.426 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104133 
                 SPG11 
                 −0.627 
                 7.432 
                 −4.181 
                 0.000 
                 0.006 
                 0.869 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000004399 
                 PLXND1 
                 −0.632 
                 7.289 
                 −2.974 
                 0.005 
                 0.047 
                 −2.360 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114353 
                 GNAI2 
                 −0.633 
                 7.463 
                 −4.184 
                 0.000 
                 0.006 
                 0.878 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000170776 
                 AKAP13 
                 −0.633 
                 8.969 
                 −3.688 
                 0.001 
                 0.013 
                 −0.516 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000159256 
                 MORC3 
                 −0.639 
                 6.338 
                 −3.719 
                 0.001 
                 0.013 
                 −0.413 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000081014 
                 AP4E1 
                 −0.641 
                 5.496 
                 −3.190 
                 0.003 
                 0.033 
                 −1.748 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114857 
                 NKTR 
                 −0.642 
                 8.398 
                 −3.627 
                 0.001 
                 0.015 
                 −0.688 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000013523 
                 ANGEL1 
                 −0.643 
                 5.372 
                 −2.940 
                 0.005 
                 0.049 
                 −2.335 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000238083 
                 LRRC37A2 
                 −0.648 
                 5.684 
                 −3.199 
                 0.003 
                 0.032 
                 −1.758 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000177873 
                 ZNF619 
                 −0.648 
                 4.047 
                 −2.969 
                 0.005 
                 0.047 
                 −2.213 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000088298 
                 EDEM2 
                 −0.649 
                 4.295 
                 −3.622 
                 0.001 
                 0.015 
                 −0.573 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000184857 
                 TMEM186 
                 −0.649 
                 2.934 
                 −3.122 
                 0.003 
                 0.037 
                 −1.823 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000186812 
                 ZNF397 
                 −0.652 
                 6.069 
                 −3.224 
                 0.002 
                 0.031 
                 −1.733 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000169372 
                 CRADD 
                 −0.654 
                 2.880 
                 −3.044 
                 0.004 
                 0.042 
                 −2.015 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173442 
                 EHBP1L1 
                 −0.655 
                 7.917 
                 −3.124 
                 0.003 
                 0.037 
                 −1.995 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000124570 
                 SERPINB6 
                 −0.656 
                 5.285 
                 −3.051 
                 0.004 
                 0.042 
                 −2.056 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000134899 
                 ERCC5 
                 −0.656 
                 5.387 
                 −3.657 
                 0.001 
                 0.014 
                 −0.515 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000149196 
                 HIKESHI 
                 −0.657 
                 4.329 
                 −3.073 
                 0.004 
                 0.040 
                 −1.954 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103064 
                 SLC7A6 
                 −0.658 
                 6.999 
                 −3.263 
                 0.002 
                 0.029 
                 −1.611 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000156171 
                 DRAM2 
                 −0.658 
                 4.993 
                 −3.063 
                 0.004 
                 0.041 
                 −2.007 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197976 
                 AKAP17A 
                 −0.662 
                 4.832 
                 −3.764 
                 0.001 
                 0.012 
                 −0.241 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000131381 
                 RBSN 
                 −0.665 
                 5.775 
                 −3.970 
                 0.000 
                 0.009 
                 0.308 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000154240 
                 CEP112 
                 −0.667 
                 4.096 
                 −3.152 
                 0.003 
                 0.035 
                 −1.797 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000066855 
                 MTFR1 
                 −0.667 
                 5.546 
                 −3.716 
                 0.001 
                 0.013 
                 −0.360 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000133943 
                 C14orf159 
                 −0.668 
                 5.982 
                 −3.370 
                 0.002 
                 0.024 
                 −1.316 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198382 
                 UVRAG 
                 −0.668 
                 5.794 
                 −3.486 
                 0.001 
                 0.020 
                 −1.005 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000177042 
                 TMEM80 
                 −0.668 
                 4.810 
                 −3.332 
                 0.002 
                 0.026 
                 −1.367 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138756 
                 BMP2K 
                 −0.670 
                 7.175 
                 −3.003 
                 0.005 
                 0.045 
                 −2.277 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000122435 
                 TRMT13 
                 −0.671 
                 4.624 
                 −3.041 
                 0.004 
                 0.042 
                 −2.077 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100280 
                 AP1B1 
                 −0.674 
                 7.158 
                 −4.203 
                 0.000 
                 0.006 
                 0.934 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000221883 
                 ARIH2OS 
                 −0.675 
                 1.845 
                 −3.269 
                 0.002 
                 0.029 
                 −1.450 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000170802 
                 FOXN2 
                 −0.676 
                 6.422 
                 −2.973 
                 0.005 
                 0.047 
                 −2.310 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000003756 
                 RBM5 
                 −0.679 
                 7.663 
                 −4.710 
                 0.000 
                 0.003 
                 2.426 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000133872 
                 SARAF 
                 −0.680 
                 7.323 
                 −3.436 
                 0.001 
                 0.021 
                 −1.193 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104205 
                 SGK3 
                 −0.681 
                 5.347 
                 −3.583 
                 0.001 
                 0.016 
                 −0.720 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162512 
                 SDC3 
                 −0.681 
                 6.528 
                 −3.044 
                 0.004 
                 0.042 
                 −2.185 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000236383 
                 LINC00854 
                 −0.684 
                 4.371 
                 −3.533 
                 0.001 
                 0.018 
                 −0.845 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198373 
                 WWP2 
                 −0.684 
                 6.105 
                 −4.593 
                 0.000 
                 0.003 
                 2.106 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000204611 
                 ZNF616 
                 −0.686 
                 4.148 
                 −3.445 
                 0.001 
                 0.021 
                 −1.059 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000159314 
                 ARHGAP27 
                 −0.689 
                 6.435 
                 −3.004 
                 0.004 
                 0.045 
                 −2.277 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172725 
                 CORO1B 
                 −0.690 
                 6.324 
                 −3.426 
                 0.001 
                 0.022 
                 −1.190 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100109 
                 TFIP11 
                 −0.690 
                 5.200 
                 −4.060 
                 0.000 
                 0.007 
                 0.578 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000153179 
                 RASSF3 
                 −0.690 
                 5.707 
                 −3.669 
                 0.001 
                 0.014 
                 −0.527 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173540 
                 GMPPB 
                 −0.691 
                 5.258 
                 −2.959 
                 0.005 
                 0.047 
                 −2.297 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168228 
                 ZCCHC4 
                 −0.691 
                 4.081 
                 −3.114 
                 0.003 
                 0.038 
                 −1.869 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104731 
                 KLHDC4 
                 −0.693 
                 6.011 
                 −3.337 
                 0.002 
                 0.026 
                 −1.393 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000128891 
                 C15orf57 
                 −0.694 
                 5.503 
                 −3.527 
                 0.001 
                 0.018 
                 −0.879 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188167 
                 TMPPE 
                 −0.694 
                 4.178 
                 −3.532 
                 0.001 
                 0.018 
                 −0.811 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000205423 
                 CNEP1R1 
                 −0.694 
                 4.539 
                 −3.925 
                 0.000 
                 0.009 
                 0.229 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163412 
                 EIF4E3 
                 −0.695 
                 5.497 
                 −3.511 
                 0.001 
                 0.019 
                 −0.930 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197928 
                 ZNF677 
                 −0.698 
                 4.092 
                 −3.029 
                 0.004 
                 0.043 
                 −2.074 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000128699 
                 ORMDL1 
                 −0.699 
                 5.708 
                 −4.181 
                 0.000 
                 0.006 
                 0.910 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000181523 
                 SGSH 
                 −0.700 
                 5.696 
                 −3.494 
                 0.001 
                 0.019 
                 −0.953 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172375 
                 C2CD2L 
                 −0.703 
                 4.651 
                 −3.293 
                 0.002 
                 0.027 
                 −1.434 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137496 
                 ID8BP 
                 −0.704 
                 4.841 
                 −3.163 
                 0.003 
                 0.034 
                 −1.778 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000073969 
                 NSF 
                 −0.704 
                 5.682 
                 −3.013 
                 0.004 
                 0.044 
                 −2.183 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185088 
                 RPS27L 
                 −0.705 
                 5.689 
                 −3.188 
                 0.003 
                 0.033 
                 −1.732 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000064601 
                 CTSA 
                 −0.707 
                 6.657 
                 −3.547 
                 0.001 
                 0.017 
                 −0.874 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000079950 
                 STX7 
                 −0.712 
                 7.347 
                 −2.960 
                 0.005 
                 0.047 
                 −2.387 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000204084 
                 INPP5B 
                 −0.713 
                 5.880 
                 −4.273 
                 0.000 
                 0.006 
                 1.163 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000180089 
                 TMEM86B 
                 −0.714 
                 2.819 
                 −3.058 
                 0.004 
                 0.041 
                 −1.989 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000180376 
                 CCDC66 
                 −0.715 
                 5.256 
                 −3.965 
                 0.000 
                 0.009 
                 0.307 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000279244 
                 AL645728.1 
                 −0.716 
                 2.017 
                 −2.961 
                 0.005 
                 0.047 
                 −2.188 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000170248 
                 PDCD6IP 
                 −0.716 
                 7.192 
                 −4.298 
                 0.000 
                 0.005 
                 1.220 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000147526 
                 TACC1 
                 −0.717 
                 7.942 
                 −3.374 
                 0.002 
                 0.024 
                 −1.361 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166848 
                 TERF2IP 
                 −0.718 
                 5.440 
                 −3.654 
                 0.001 
                 0.014 
                 −0.539 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135655 
                 USP15 
                 −0.719 
                 7.237 
                 −4.217 
                 0.000 
                 0.006 
                 0.978 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000178971 
                 CTC1 
                 −0.719 
                 5.953 
                 −3.032 
                 0.004 
                 0.043 
                 −2.171 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000167202 
                 TBC1D2B 
                 −0.719 
                 6.979 
                 −3.961 
                 0.000 
                 0.009 
                 0.261 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000087266 
                 SH3BP2 
                 −0.719 
                 7.638 
                 −3.313 
                 0.002 
                 0.026 
                 −1.517 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114026 
                 OGG1 
                 −0.719 
                 5.147 
                 −3.520 
                 0.001 
                 0.018 
                 −0.892 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000205707 
                 LYRM5 
                 −0.721 
                 3.253 
                 −3.541 
                 0.001 
                 0.018 
                 −0.782 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000159082 
                 SYNJ1 
                 −0.722 
                 4.955 
                 −2.994 
                 0.005 
                 0.045 
                 −2.183 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163320 
                 CGGBP1 
                 −0.722 
                 6.698 
                 −3.752 
                 0.001 
                 0.012 
                 −0.315 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000213533 
                 TMEM110 
                 −0.723 
                 5.112 
                 −3.784 
                 0.000 
                 0.011 
                 −0.168 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137509 
                 PRCP 
                 −0.723 
                 5.835 
                 −3.485 
                 0.001 
                 0.020 
                 −0.998 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172530 
                 BANP 
                 −0.724 
                 5.002 
                 −4.058 
                 0.000 
                 0.007 
                 0.570 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197860 
                 SGTB 
                 −0.725 
                 5.122 
                 −3.444 
                 0.001 
                 0.021 
                 −1.090 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000040933 
                 INPP4A 
                 −0.725 
                 6.871 
                 −3.282 
                 0.002 
                 0.028 
                 −1.583 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000140577 
                 CRTC3 
                 −0.725 
                 6.519 
                 −3.202 
                 0.003 
                 0.032 
                 −1.783 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168876 
                 ANKRD49 
                 −0.727 
                 4.186 
                 −3.358 
                 0.002 
                 0.025 
                 −1.265 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000055147 
                 FAM114A2 
                 −0.730 
                 4.511 
                 −3.368 
                 0.002 
                 0.024 
                 −1.236 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000112419 
                 PHACTR2 
                 −0.731 
                 6.741 
                 −3.694 
                 0.001 
                 0.013 
                 −0.497 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114395 
                 CYB561D2 
                 −0.732 
                 2.971 
                 −2.945 
                 0.005 
                 0.048 
                 −2.230 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135686 
                 KLHL36 
                 −0.733 
                 6.418 
                 −3.495 
                 0.001 
                 0.019 
                 −0.991 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103248 
                 MTHFSD 
                 −0.734 
                 4.540 
                 −3.934 
                 0.000 
                 0.009 
                 0.249 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000175309 
                 PHYKPL 
                 −0.735 
                 6.768 
                 −4.150 
                 0.000 
                 0.006 
                 0.793 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000184178 
                 SCFD2 
                 −0.736 
                 4.365 
                 −3.334 
                 0.002 
                 0.026 
                 −1.350 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000102871 
                 TRADD 
                 −0.736 
                 4.713 
                 −3.751 
                 0.001 
                 0.012 
                 −0.243 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114316 
                 USP4 
                 −0.736 
                 6.195 
                 −4.435 
                 0.000 
                 0.004 
                 1.637 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000155393 
                 HEATR3 
                 −0.740 
                 5.028 
                 −3.534 
                 0.001 
                 0.018 
                 −0.838 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173757 
                 STAT5B 
                 −0.741 
                 6.586 
                 −3.412 
                 0.001 
                 0.022 
                 −1.243 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000090857 
                 PDPR 
                 −0.745 
                 6.858 
                 −3.572 
                 0.001 
                 0.016 
                 −0.814 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104660 
                 LEPROTL1 
                 −0.745 
                 5.703 
                 −3.177 
                 0.003 
                 0.033 
                 −1.790 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000147010 
                 SH3KBP1 
                 −0.747 
                 5.990 
                 −3.037 
                 0.004 
                 0.043 
                 −2.154 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185404 
                 SP140L 
                 −0.747 
                 5.838 
                 −3.231 
                 0.002 
                 0.031 
                 −1.681 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163932 
                 PRKCD 
                 −0.750 
                 5.025 
                 −3.028 
                 0.004 
                 0.043 
                 −2.114 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000078304 
                 PPP2R5C 
                 −0.750 
                 7.554 
                 −3.731 
                 0.001 
                 0.013 
                 −0.397 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000110719 
                 TCIRG1 
                 −0.753 
                 6.715 
                 −3.062 
                 0.004 
                 0.041 
                 −2.129 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000184939 
                 ZFP90 
                 −0.754 
                 5.500 
                 −3.473 
                 0.001 
                 0.020 
                 −1.029 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165494 
                 PCF11 
                 −0.754 
                 7.134 
                 −3.747 
                 0.001 
                 0.012 
                 −0.335 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000217555 
                 CKLF 
                 −0.756 
                 3.246 
                 −3.152 
                 0.003 
                 0.035 
                 −1.740 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198001 
                 IRAK4 
                 −0.756 
                 5.564 
                 −3.170 
                 0.003 
                 0.034 
                 −1.807 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164081 
                 TEX264 
                 −0.758 
                 4.464 
                 −3.092 
                 0.004 
                 0.039 
                 −1.920 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000204070 
                 SYS1 
                 −0.758 
                 5.270 
                 −4.531 
                 0.000 
                 0.004 
                 1.921 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000140280 
                 LYSMD2 
                 −0.758 
                 2.595 
                 −2.955 
                 0.005 
                 0.048 
                 −2.212 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000127419 
                 TMEM175 
                 −0.759 
                 4.538 
                 −2.959 
                 0.005 
                 0.047 
                 −2.231 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000204592 
                 HLA-E 
                 −0.759 
                 9.225 
                 −3.591 
                 0.001 
                 0.016 
                 −0.783 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130429 
                 ARPC1B 
                 −0.763 
                 7.152 
                 −4.335 
                 0.000 
                 0.005 
                 1.338 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135272 
                 MDFIC 
                 −0.766 
                 6.273 
                 −3.000 
                 0.005 
                 0.045 
                 −2.261 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000054611 
                 TBC1D22A 
                 −0.768 
                 6.114 
                 −3.499 
                 0.001 
                 0.019 
                 −1.000 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000076513 
                 ANKRD13A 
                 −0.770 
                 6.726 
                 −3.782 
                 0.000 
                 0.012 
                 −0.227 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163635 
                 ATXN7 
                 −0.771 
                 6.929 
                 −3.959 
                 0.000 
                 0.009 
                 0.253 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000139597 
                 N4BP2L1 
                 −0.775 
                 4.663 
                 −3.201 
                 0.003 
                 0.032 
                 −1.681 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000110047 
                 EHD1 
                 −0.777 
                 6.373 
                 −3.533 
                 0.001 
                 0.018 
                 −0.906 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000177311 
                 ZBTB38 
                 −0.777 
                 7.309 
                 −3.978 
                 0.000 
                 0.008 
                 0.295 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138744 
                 NAAA 
                 −0.777 
                 4.258 
                 −3.386 
                 0.002 
                 0.023 
                 −1.217 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136770 
                 DNAJC1 
                 −0.778 
                 4.180 
                 −3.257 
                 0.002 
                 0.029 
                 −1.510 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000187239 
                 FNBP1 
                 −0.780 
                 6.844 
                 −3.131 
                 0.003 
                 0.037 
                 −1.962 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000149177 
                 PTPRJ 
                 −0.780 
                 6.279 
                 −3.466 
                 0.001 
                 0.020 
                 −1.086 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000150433 
                 TMEM218 
                 −0.780 
                 4.085 
                 −3.224 
                 0.002 
                 0.031 
                 −1.589 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000140853 
                 NLRC5 
                 −0.781 
                 7.910 
                 −3.033 
                 0.004 
                 0.043 
                 −2.211 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188033 
                 ZNF490 
                 −0.784 
                 4.213 
                 −3.999 
                 0.000 
                 0.008 
                 0.426 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000205045 
                 SLFN12L 
                 −0.785 
                 5.245 
                 −3.351 
                 0.002 
                 0.025 
                 −1.348 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000102893 
                 PHKB 
                 −0.785 
                 6.733 
                 −4.752 
                 0.000 
                 0.002 
                 2.567 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000144843 
                 ADPRH 
                 −0.785 
                 3.779 
                 −3.171 
                 0.003 
                 0.034 
                 −1.714 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188997 
                 KCTD21 
                 −0.786 
                 4.129 
                 −4.249 
                 0.000 
                 0.006 
                 1.131 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000123104 
                 ITPR2 
                 −0.792 
                 7.340 
                 −3.848 
                 0.000 
                 0.010 
                 −0.074 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000006638 
                 TBXA2R 
                 −0.792 
                 2.448 
                 −3.131 
                 0.003 
                 0.037 
                 −1.789 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000069943 
                 PIGB 
                 −0.793 
                 4.501 
                 −4.623 
                 0.000 
                 0.003 
                 2.201 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000145022 
                 TCTA 
                 −0.796 
                 4.121 
                 −3.626 
                 0.001 
                 0.015 
                 −0.569 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135048 
                 TMEM2 
                 −0.800 
                 7.455 
                 −3.469 
                 0.001 
                 0.020 
                 −1.110 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000167377 
                 ZNF23 
                 −0.801 
                 4.091 
                 −3.001 
                 0.005 
                 0.045 
                 −2.134 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000054967 
                 RELT 
                 −0.802 
                 5.891 
                 −2.957 
                 0.005 
                 0.048 
                 −2.361 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196199 
                 MPHOSPH8 
                 −0.807 
                 5.963 
                 −4.237 
                 0.000 
                 0.006 
                 1.064 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130307 
                 USHBP1 
                 −0.807 
                 3.379 
                 −3.187 
                 0.003 
                 0.033 
                 −1.679 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198223 
                 CSF2RA 
                 −0.809 
                 3.989 
                 −3.119 
                 0.003 
                 0.037 
                 −1.857 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000141298 
                 SSH2 
                 −0.809 
                 7.268 
                 −3.798 
                 0.000 
                 0.011 
                 −0.216 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000178917 
                 ZNF852 
                 −0.810 
                 3.369 
                 −3.333 
                 0.002 
                 0.026 
                 −1.313 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160439 
                 RDH13 
                 −0.810 
                 5.578 
                 −3.204 
                 0.003 
                 0.032 
                 −1.732 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164414 
                 SLC35A1 
                 −0.813 
                 3.860 
                 −3.724 
                 0.001 
                 0.013 
                 −0.306 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000181513 
                 ACBD4 
                 −0.815 
                 3.403 
                 −3.105 
                 0.003 
                 0.038 
                 −1.871 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000262246 
                 CORO7 
                 −0.816 
                 5.814 
                 −3.243 
                 0.002 
                 0.030 
                 −1.619 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103061 
                 SLC7A6OS 
                 −0.825 
                 4.833 
                 −4.319 
                 0.000 
                 0.005 
                 1.325 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166974 
                 MAPRE2 
                 −0.825 
                 5.277 
                 −3.066 
                 0.004 
                 0.041 
                 −2.035 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000155085 
                 AK9 
                 −0.825 
                 3.484 
                 −3.438 
                 0.001 
                 0.021 
                 −1.055 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198833 
                 UBE2J1 
                 −0.826 
                 6.412 
                 −3.373 
                 0.002 
                 0.024 
                 −1.328 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000159110 
                 IFNAR2 
                 −0.826 
                 5.668 
                 −4.147 
                 0.000 
                 0.006 
                 0.814 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000177663 
                 ID7RA 
                 −0.827 
                 6.232 
                 −3.718 
                 0.001 
                 0.013 
                 −0.400 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000134109 
                 EDEM1 
                 −0.827 
                 7.327 
                 −4.000 
                 0.000 
                 0.008 
                 0.356 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103150 
                 MLYCD 
                 −0.828 
                 5.555 
                 −3.494 
                 0.001 
                 0.019 
                 −0.972 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168792 
                 ABHD15 
                 −0.828 
                 4.603 
                 −3.723 
                 0.001 
                 0.013 
                 −0.322 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000260916 
                 CCPG1 
                 −0.829 
                 5.924 
                 −2.928 
                 0.006 
                 0.050 
                 −2.419 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000120910 
                 PPP3CC 
                 −0.838 
                 4.548 
                 −3.377 
                 0.002 
                 0.024 
                 −1.227 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000247596 
                 TWF2 
                 −0.840 
                 4.632 
                 −3.901 
                 0.000 
                 0.009 
                 0.161 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000213809 
                 KLRK1 
                 −0.841 
                 4.097 
                 −3.184 
                 0.003 
                 0.033 
                 −1.695 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196544 
                 BORCS6 
                 −0.842 
                 2.801 
                 −3.450 
                 0.001 
                 0.021 
                 −0.999 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000134545 
                 KLRC1 
                 −0.842 
                 2.452 
                 −2.982 
                 0.005 
                 0.046 
                 −2.145 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103479 
                 RBL2 
                 −0.845 
                 7.342 
                 −5.089 
                 0.000 
                 0.001 
                 3.576 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000228570 
                 NUTM2E 
                 −0.846 
                 2.282 
                 −3.245 
                 0.002 
                 0.030 
                 −1.509 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137486 
                 ARRB1 
                 −0.847 
                 4.630 
                 −3.344 
                 0.002 
                 0.025 
                 −1.294 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166971 
                 AKTIP 
                 −0.848 
                 4.686 
                 −3.324 
                 0.002 
                 0.026 
                 −1.348 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000205542 
                 TMSB4X 
                 −0.849 
                 9.240 
                 −3.655 
                 0.001 
                 0.014 
                 −0.598 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000205268 
                 PDE7A 
                 −0.849 
                 7.026 
                 −3.981 
                 0.000 
                 0.008 
                 0.312 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138185 
                 ENTPD1 
                 −0.849 
                 6.268 
                 −3.252 
                 0.002 
                 0.029 
                 −1.612 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000068724 
                 TTC7A 
                 −0.852 
                 6.470 
                 −3.585 
                 0.001 
                 0.016 
                 −0.755 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000152689 
                 RASGRP3 
                 −0.854 
                 5.719 
                 −3.899 
                 0.000 
                 0.009 
                 0.113 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000032219 
                 ARID4A 
                 −0.854 
                 5.738 
                 −4.259 
                 0.000 
                 0.006 
                 1.150 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162241 
                 SLC25A45 
                 −0.856 
                 5.265 
                 −3.420 
                 0.001 
                 0.022 
                 −1.168 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173559 
                 NABP1 
                 −0.856 
                 8.027 
                 −3.703 
                 0.001 
                 0.013 
                 −0.481 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173698 
                 ADGRG2 
                 −0.859 
                 3.974 
                 −3.444 
                 0.001 
                 0.021 
                 −1.058 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000221995 
                 TIAF1 
                 −0.859 
                 4.552 
                 −4.345 
                 0.000 
                 0.005 
                 1.401 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000258555 
                 SPECC1L- 
                 −0.860 
                 2.914 
                 −2.974 
                 0.005 
                 0.047 
                 −2.172 
               
               
                   
                   
                 ADORA2A 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000069966 
                 GNB5 
                 −0.862 
                 5.827 
                 −4.168 
                 0.000 
                 0.006 
                 0.868 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000047346 
                 FAM214A 
                 −0.862 
                 6.618 
                 −3.039 
                 0.004 
                 0.043 
                 −2.179 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000013364 
                 MVP 
                 −0.863 
                 7.190 
                 −3.959 
                 0.000 
                 0.009 
                 0.258 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000027075 
                 PRKCH 
                 −0.864 
                 6.399 
                 −3.440 
                 0.001 
                 0.021 
                 −1.142 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000028116 
                 VRK2 
                 −0.864 
                 5.123 
                 −3.404 
                 0.001 
                 0.023 
                 −1.208 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197619 
                 ZNF615 
                 −0.867 
                 3.811 
                 −3.784 
                 0.000 
                 0.011 
                 −0.152 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165972 
                 CCDC38 
                 −0.869 
                 2.296 
                 −3.072 
                 0.004 
                 0.040 
                 −1.933 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101347 
                 SAMHD1 
                 −0.870 
                 7.445 
                 −3.422 
                 0.001 
                 0.022 
                 −1.206 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000271605 
                 MILR1 
                 −0.873 
                 3.197 
                 −3.740 
                 0.001 
                 0.012 
                 −0.257 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101160 
                 CTSZ 
                 −0.873 
                 6.724 
                 −4.612 
                 0.000 
                 0.003 
                 2.145 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166436 
                 TRIM66 
                 −0.874 
                 5.651 
                 −3.006 
                 0.004 
                 0.045 
                 −2.204 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000241399 
                 CD302 
                 −0.877 
                 4.228 
                 −2.939 
                 0.005 
                 0.049 
                 −2.310 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137478 
                 FCHSD2 
                 −0.879 
                 6.271 
                 −4.119 
                 0.000 
                 0.007 
                 0.722 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000159496 
                 RGL4 
                 −0.880 
                 3.332 
                 −3.094 
                 0.004 
                 0.039 
                 −1.903 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188452 
                 CERKL 
                 −0.880 
                 3.996 
                 −3.555 
                 0.001 
                 0.017 
                 −0.763 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135090 
                 TAOK3 
                 −0.881 
                 6.128 
                 −5.609 
                 0.000 
                 0.001 
                 5.167 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000181045 
                 SLC26A11 
                 −0.884 
                 4.331 
                 −3.143 
                 0.003 
                 0.036 
                 −1.795 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000178695 
                 KCTD12 
                 −0.887 
                 7.260 
                 −3.418 
                 0.001 
                 0.022 
                 −1.222 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000109323 
                 MANBA 
                 −0.889 
                 5.513 
                 −3.819 
                 0.000 
                 0.011 
                 −0.096 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000109063 
                 MYH3 
                 −0.890 
                 3.473 
                 −2.991 
                 0.005 
                 0.045 
                 −2.161 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000106560 
                 GIMAP2 
                 −0.891 
                 4.214 
                 −3.879 
                 0.000 
                 0.010 
                 0.104 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163719 
                 MTMR14 
                 −0.891 
                 5.326 
                 −5.298 
                 0.000 
                 0.001 
                 4.214 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000184619 
                 KRBA2 
                 −0.892 
                 2.744 
                 −3.768 
                 0.001 
                 0.012 
                 −0.179 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000154144 
                 TBRG1 
                 −0.896 
                 5.684 
                 −6.402 
                 0.000 
                 0.000 
                 7.577 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000178607 
                 ERN1 
                 −0.896 
                 6.416 
                 −3.059 
                 0.004 
                 0.041 
                 −2.111 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000178927 
                 C17orf62 
                 −0.898 
                 7.044 
                 −4.009 
                 0.000 
                 0.008 
                 0.383 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000174718 
                 KIAA1551 
                 −0.900 
                 7.676 
                 −3.107 
                 0.003 
                 0.038 
                 −2.041 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173011 
                 TADA2B 
                 −0.905 
                 5.005 
                 −4.640 
                 0.000 
                 0.003 
                 2.252 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000241839 
                 PLEKHO2 
                 −0.905 
                 5.640 
                 −4.107 
                 0.000 
                 0.007 
                 0.706 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197043 
                 ANXA6 
                 −0.906 
                 6.430 
                 −3.243 
                 0.002 
                 0.030 
                 −1.642 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163686 
                 ABHD6 
                 −0.906 
                 3.150 
                 −3.542 
                 0.001 
                 0.018 
                 −0.776 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000076928 
                 ARHGEF1 
                 −0.907 
                 7.681 
                 −4.175 
                 0.000 
                 0.006 
                 0.852 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196405 
                 EVL 
                 −0.908 
                 7.403 
                 −3.039 
                 0.004 
                 0.043 
                 −2.203 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000026297 
                 RNASET2 
                 −0.908 
                 6.213 
                 −3.911 
                 0.000 
                 0.009 
                 0.133 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114779 
                 ABHD14B 
                 −0.908 
                 4.423 
                 −3.581 
                 0.001 
                 0.016 
                 −0.688 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000145685 
                 LHFPL2 
                 −0.909 
                 6.653 
                 −3.518 
                 0.001 
                 0.018 
                 −0.924 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000019144 
                 PHLDB1 
                 −0.910 
                 7.590 
                 −3.192 
                 0.003 
                 0.033 
                 −1.821 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000121281 
                 ADCY7 
                 −0.911 
                 6.971 
                 −3.507 
                 0.001 
                 0.019 
                 −0.975 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000277531 
                 LLNLF- 
                 −0.921 
                 1.751 
                 −3.257 
                 0.002 
                 0.029 
                 −1.477 
               
               
                   
                   
                 187D8.1 
                   
                   
                   
                   
                   
                   
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000118596 
                 SLC16A7 
                 −0.922 
                 5.772 
                 −2.937 
                 0.005 
                 0.049 
                 −2.418 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000145029 
                 NICN1 
                 −0.922 
                 4.136 
                 −3.353 
                 0.002 
                 0.025 
                 −1.271 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000159140 
                 SON 
                 −0.923 
                 9.249 
                 −3.684 
                 0.001 
                 0.013 
                 −0.508 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137474 
                 MYO7A 
                 −0.923 
                 4.279 
                 −3.184 
                 0.003 
                 0.033 
                 −1.686 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000213445 
                 SIPA1 
                 −0.928 
                 6.070 
                 −3.863 
                 0.000 
                 0.010 
                 −0.001 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000128294 
                 TPST2 
                 −0.929 
                 5.303 
                 −4.394 
                 0.000 
                 0.004 
                 1.529 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000003402 
                 CFLAR 
                 −0.929 
                 9.324 
                 −5.232 
                 0.000 
                 0.001 
                 4.014 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125457 
                 MIF4GD 
                 −0.930 
                 3.375 
                 −3.730 
                 0.001 
                 0.013 
                 −0.286 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000176715 
                 ACSF3 
                 −0.932 
                 6.493 
                 −4.466 
                 0.000 
                 0.004 
                 1.720 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000183722 
                 LHFP 
                 −0.935 
                 5.048 
                 −3.400 
                 0.001 
                 0.023 
                 −1.164 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198879 
                 SFMBT2 
                 −0.936 
                 5.954 
                 −3.209 
                 0.003 
                 0.032 
                 −1.683 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000171488 
                 LRRC8C 
                 −0.938 
                 6.054 
                 −3.643 
                 0.001 
                 0.015 
                 −0.591 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000139436 
                 GIT2 
                 −0.941 
                 6.684 
                 −6.050 
                 0.000 
                 0.000 
                 6.540 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000120860 
                 CCDC53 
                 −0.943 
                 4.073 
                 −4.870 
                 0.000 
                 0.002 
                 2.913 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000144711 
                 IQSEC1 
                 −0.944 
                 6.846 
                 −4.304 
                 0.000 
                 0.005 
                 1.234 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000091879 
                 ANGPT2 
                 −0.945 
                 5.375 
                 −3.875 
                 0.000 
                 0.010 
                 0.046 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000170542 
                 SERPINB9 
                 −0.946 
                 6.327 
                 −3.449 
                 0.001 
                 0.021 
                 −1.148 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000181007 
                 ZFP82 
                 −0.949 
                 3.630 
                 −4.320 
                 0.000 
                 0.005 
                 1.331 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000082512 
                 TRAF5 
                 −0.949 
                 6.182 
                 −3.446 
                 0.001 
                 0.021 
                 −1.124 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196535 
                 MYO18A 
                 −0.949 
                 7.449 
                 −5.101 
                 0.000 
                 0.001 
                 3.617 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000033867 
                 SLC4A7 
                 −0.951 
                 6.919 
                 −4.452 
                 0.000 
                 0.004 
                 1.670 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000149577 
                 SIDT2 
                 −0.951 
                 6.053 
                 −5.016 
                 0.000 
                 0.002 
                 3.366 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196954 
                 CASP4 
                 −0.952 
                 6.337 
                 −3.162 
                 0.003 
                 0.034 
                 −1.801 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000153551 
                 CMTM7 
                 −0.952 
                 4.175 
                 −3.273 
                 0.002 
                 0.029 
                 −1.500 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000183023 
                 SLC8A1 
                 −0.953 
                 5.831 
                 −3.049 
                 0.004 
                 0.042 
                 −2.080 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000174306 
                 ZHX3 
                 −0.954 
                 5.962 
                 −3.535 
                 0.001 
                 0.018 
                 −0.879 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198624 
                 CCDC69 
                 −0.955 
                 5.502 
                 −3.766 
                 0.001 
                 0.012 
                 −0.263 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000126860 
                 EVI2A 
                 −0.956 
                 4.368 
                 −3.277 
                 0.002 
                 0.028 
                 −1.469 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000128604 
                 IRF5 
                 −0.957 
                 4.473 
                 −3.799 
                 0.000 
                 0.011 
                 −0.111 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172716 
                 SLFN11 
                 −0.958 
                 5.773 
                 −3.127 
                 0.003 
                 0.037 
                 −1.892 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164483 
                 SAMD3 
                 −0.960 
                 2.608 
                 −2.927 
                 0.006 
                 0.050 
                 −2.269 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000069974 
                 RAB27A 
                 −0.962 
                 5.335 
                 −4.918 
                 0.000 
                 0.002 
                 3.071 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143891 
                 GALM 
                 −0.964 
                 4.026 
                 −3.514 
                 0.001 
                 0.019 
                 −0.852 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000244274 
                 DBNDD2 
                 −0.965 
                 4.028 
                 −3.572 
                 0.001 
                 0.016 
                 −0.694 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000186469 
                 GNG2 
                 −0.967 
                 5.157 
                 −3.055 
                 0.004 
                 0.041 
                 −2.029 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000105483 
                 CARD8 
                 −0.968 
                 6.511 
                 −4.251 
                 0.000 
                 0.006 
                 1.093 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000145246 
                 ATP10D 
                 −0.968 
                 6.334 
                 −3.312 
                 0.002 
                 0.026 
                 −1.435 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000111885 
                 MAN1A1 
                 −0.970 
                 6.377 
                 −3.324 
                 0.002 
                 0.026 
                 −1.453 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000115993 
                 TRAK2 
                 −0.970 
                 6.070 
                 −4.284 
                 0.000 
                 0.005 
                 1.209 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000141968 
                 VAV1 
                 −0.971 
                 4.844 
                 −3.936 
                 0.000 
                 0.009 
                 0.233 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000087589 
                 CASS4 
                 −0.973 
                 3.162 
                 −3.452 
                 0.001 
                 0.021 
                 −1.000 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000169499 
                 PLEKHA2 
                 −0.977 
                 7.164 
                 −3.895 
                 0.000 
                 0.009 
                 0.058 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000145416 
                 MARCH1 
                 −0.978 
                 6.187 
                 −3.446 
                 0.001 
                 0.021 
                 −1.128 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198673 
                 FAM19A2 
                 −0.979 
                 2.686 
                 −3.372 
                 0.002 
                 0.024 
                 −1.200 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000182578 
                 CSF1R 
                 −0.980 
                 6.325 
                 −3.321 
                 0.002 
                 0.026 
                 −1.435 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000031081 
                 ARHGAP31 
                 −0.981 
                 6.390 
                 −4.116 
                 0.000 
                 0.007 
                 0.694 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164308 
                 ERAP2 
                 −0.986 
                 6.453 
                 −3.573 
                 0.001 
                 0.016 
                 −0.800 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160613 
                 PCSK7 
                 −0.988 
                 7.889 
                 −5.743 
                 0.000 
                 0.001 
                 5.591 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000010810 
                 FYN 
                 −0.988 
                 6.392 
                 −3.755 
                 0.001 
                 0.012 
                 −0.327 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198668 
                 CALM1 
                 −0.990 
                 8.268 
                 −4.944 
                 0.000 
                 0.002 
                 3.134 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166946 
                 CCNDBP1 
                 −0.995 
                 5.713 
                 −4.851 
                 0.000 
                 0.002 
                 2.872 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000123146 
                 ADGRE5 
                 −0.995 
                 6.191 
                 −4.135 
                 0.000 
                 0.007 
                 0.754 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000161791 
                 FMNL3 
                 −0.997 
                 7.528 
                 −4.876 
                 0.000 
                 0.002 
                 2.926 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000142185 
                 TRPM2 
                 −0.997 
                 4.995 
                 −2.966 
                 0.005 
                 0.047 
                 −2.266 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000070190 
                 DAPP1 
                 −0.997 
                 5.574 
                 −3.020 
                 0.004 
                 0.044 
                 −2.185 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000254087 
                 LYN 
                 −1.002 
                 6.334 
                 −3.214 
                 0.003 
                 0.032 
                 −1.705 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000110514 
                 MADD 
                 −1.002 
                 6.497 
                 −4.379 
                 0.000 
                 0.005 
                 1.460 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172037 
                 LAMB2 
                 −1.006 
                 6.653 
                 −3.271 
                 0.002 
                 0.029 
                 −1.578 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000020577 
                 SAMD4A 
                 −1.007 
                 6.187 
                 −3.020 
                 0.004 
                 0.044 
                 −2.218 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000129675 
                 ARHGEF6 
                 −1.008 
                 5.572 
                 −3.032 
                 0.004 
                 0.043 
                 −2.097 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000142347 
                 MYO1F 
                 −1.011 
                 5.629 
                 −3.413 
                 0.001 
                 0.022 
                 −1.165 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000069493 
                 CLEC2D 
                 −1.014 
                 6.220 
                 −3.082 
                 0.004 
                 0.040 
                 −2.057 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000157350 
                 ST3GAL2 
                 −1.014 
                 6.304 
                 −4.288 
                 0.000 
                 0.005 
                 1.194 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130038 
                 CRACR2A 
                 −1.021 
                 4.941 
                 −3.769 
                 0.001 
                 0.012 
                 −0.223 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188677 
                 PARVB 
                 −1.024 
                 5.176 
                 −3.359 
                 0.002 
                 0.024 
                 −1.300 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000170949 
                 ZNF160 
                 −1.025 
                 5.448 
                 −3.183 
                 0.003 
                 0.033 
                 −1.808 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000128340 
                 RAC2 
                 −1.027 
                 5.883 
                 −3.025 
                 0.004 
                 0.043 
                 −2.180 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000087495 
                 PHACTR3 
                 −1.027 
                 2.594 
                 −3.066 
                 0.004 
                 0.041 
                 −1.961 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000099308 
                 MAST3 
                 −1.029 
                 5.307 
                 −3.750 
                 0.001 
                 0.012 
                 −0.280 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162777 
                 DENND2D 
                 −1.035 
                 5.905 
                 −3.168 
                 0.003 
                 0.034 
                 −1.823 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000048471 
                 SNX29 
                 −1.036 
                 6.604 
                 −4.789 
                 0.000 
                 0.002 
                 2.679 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000158985 
                 CDC42SE2 
                 −1.042 
                 6.699 
                 −3.934 
                 0.000 
                 0.009 
                 0.189 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101109 
                 STK4 
                 −1.043 
                 7.643 
                 −5.129 
                 0.000 
                 0.001 
                 3.700 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000105339 
                 DENND3 
                 −1.044 
                 7.060 
                 −3.804 
                 0.000 
                 0.011 
                 −0.189 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000068028 
                 RASSF1 
                 −1.050 
                 4.918 
                 −5.050 
                 0.000 
                 0.002 
                 3.458 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166128 
                 RAB8B 
                 −1.051 
                 6.318 
                 −3.806 
                 0.000 
                 0.011 
                 −0.148 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125637 
                 PSD4 
                 −1.053 
                 7.444 
                 −4.227 
                 0.000 
                 0.006 
                 1.007 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168404 
                 MLKL 
                 −1.053 
                 5.151 
                 −3.726 
                 0.001 
                 0.013 
                 −0.318 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000012779 
                 ALOX5 
                 −1.057 
                 4.999 
                 −2.956 
                 0.005 
                 0.048 
                 −2.266 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000116852 
                 KIF21B 
                 −1.058 
                 5.481 
                 −3.609 
                 0.001 
                 0.015 
                 −0.683 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138641 
                 HERC3 
                 −1.059 
                 6.303 
                 −4.207 
                 0.000 
                 0.006 
                 0.982 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000066056 
                 TIE1 
                 −1.062 
                 4.404 
                 −3.395 
                 0.002 
                 0.023 
                 −1.168 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000129566 
                 TEP1 
                 −1.064 
                 7.063 
                 −5.355 
                 0.000 
                 0.001 
                 4.394 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100600 
                 LGMN 
                 −1.069 
                 6.142 
                 −4.247 
                 0.000 
                 0.006 
                 1.108 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000065809 
                 FAM107B 
                 −1.070 
                 6.305 
                 −3.018 
                 0.004 
                 0.044 
                 −2.210 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000182158 
                 CREB3L2 
                 −1.074 
                 7.465 
                 −3.300 
                 0.002 
                 0.027 
                 −1.556 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000059377 
                 TBXAS1 
                 −1.075 
                 4.305 
                 −4.134 
                 0.000 
                 0.007 
                 0.812 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163297 
                 ANTXR2 
                 −1.076 
                 5.846 
                 −3.086 
                 0.004 
                 0.039 
                 −2.003 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000146376 
                 ARHGAP18 
                 −1.078 
                 5.226 
                 −4.124 
                 0.000 
                 0.007 
                 0.774 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000115935 
                 WIPF1 
                 −1.080 
                 7.390 
                 −3.760 
                 0.001 
                 0.012 
                 −0.321 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000071073 
                 MGAT4A 
                 −1.081 
                 6.301 
                 −3.088 
                 0.004 
                 0.039 
                 −2.016 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103047 
                 TANGO6 
                 −1.086 
                 5.126 
                 −4.426 
                 0.000 
                 0.004 
                 1.628 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000092929 
                 UNC13D 
                 −1.086 
                 5.772 
                 −3.623 
                 0.001 
                 0.015 
                 −0.621 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000150995 
                 ITPR1 
                 −1.086 
                 6.573 
                 −3.033 
                 0.004 
                 0.043 
                 −2.173 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197892 
                 KIF13B 
                 −1.087 
                 6.143 
                 −4.615 
                 0.000 
                 0.003 
                 2.168 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000161955 
                 TNFSF13 
                 −1.093 
                 4.314 
                 −3.977 
                 0.000 
                 0.008 
                 0.368 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000206538 
                 VGLL3 
                 −1.094 
                 6.158 
                 −3.350 
                 0.002 
                 0.025 
                 −1.382 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000106991 
                 ENG 
                 −1.097 
                 6.195 
                 −5.131 
                 0.000 
                 0.001 
                 3.710 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000116191 
                 RALGPS2 
                 −1.098 
                 6.321 
                 −3.450 
                 0.001 
                 0.021 
                 −1.107 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168461 
                 RAB31 
                 −1.098 
                 7.199 
                 −3.419 
                 0.001 
                 0.022 
                 −1.213 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000134242 
                 PTPN22 
                 −1.099 
                 4.137 
                 −3.277 
                 0.002 
                 0.028 
                 −1.453 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137502 
                 RAB30 
                 −1.103 
                 5.630 
                 −3.186 
                 0.003 
                 0.033 
                 −1.766 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000155629 
                 PIK3AP1 
                 −1.103 
                 5.975 
                 −3.337 
                 0.002 
                 0.026 
                 −1.428 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000093072 
                 CECR1 
                 −1.110 
                 6.003 
                 −3.008 
                 0.004 
                 0.045 
                 −2.223 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000171310 
                 CHST11 
                 −1.112 
                 6.371 
                 −4.828 
                 0.000 
                 0.002 
                 2.801 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163820 
                 FYCO1 
                 −1.113 
                 6.072 
                 −3.865 
                 0.000 
                 0.010 
                 0.026 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000213648 
                 SULT1A4 
                 −1.114 
                 2.810 
                 −3.098 
                 0.003 
                 0.039 
                 −1.872 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000145020 
                 AMT 
                 −1.117 
                 4.533 
                 −3.312 
                 0.002 
                 0.026 
                 −1.396 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000096996 
                 IL12RB1 
                 −1.117 
                 4.014 
                 −3.661 
                 0.001 
                 0.014 
                 −0.480 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000039523 
                 FAM65A 
                 −1.120 
                 6.034 
                 −5.351 
                 0.000 
                 0.001 
                 4.381 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000175155 
                 YPEL2 
                 −1.121 
                 5.977 
                 −4.427 
                 0.000 
                 0.004 
                 1.621 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198805 
                 PNP 
                 −1.125 
                 5.417 
                 −3.776 
                 0.000 
                 0.012 
                 −0.166 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000157734 
                 SNX22 
                 −1.127 
                 4.420 
                 −3.071 
                 0.004 
                 0.040 
                 −2.021 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000187800 
                 PEAR1 
                 −1.128 
                 4.040 
                 −3.167 
                 0.003 
                 0.034 
                 −1.727 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000176435 
                 CLEC14A 
                 −1.130 
                 2.626 
                 −3.664 
                 0.001 
                 0.014 
                 −0.447 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000149311 
                 ATM 
                 −1.131 
                 8.318 
                 −4.414 
                 0.000 
                 0.004 
                 1.543 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188641 
                 DPYD 
                 −1.134 
                 6.028 
                 −3.456 
                 0.001 
                 0.021 
                 −1.037 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000105366 
                 SIGLEC8 
                 −1.135 
                 2.659 
                 −3.270 
                 0.002 
                 0.029 
                 −1.451 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100385 
                 IL2RB 
                 −1.138 
                 5.071 
                 −3.778 
                 0.000 
                 0.012 
                 −0.187 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000106948 
                 AKNA 
                 −1.139 
                 7.642 
                 −2.973 
                 0.005 
                 0.047 
                 −2.371 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135074 
                 ADAM19 
                 −1.143 
                 6.949 
                 −4.202 
                 0.000 
                 0.006 
                 0.931 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000047365 
                 ARAP2 
                 −1.144 
                 7.054 
                 −3.674 
                 0.001 
                 0.014 
                 −0.539 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172243 
                 CLEC7A 
                 −1.145 
                 5.358 
                 −3.865 
                 0.000 
                 0.010 
                 0.056 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163703 
                 CRELD1 
                 −1.145 
                 3.910 
                 −4.256 
                 0.000 
                 0.006 
                 1.152 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197134 
                 ZNF257 
                 −1.147 
                 2.637 
                 −4.418 
                 0.000 
                 0.004 
                 1.602 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000176927 
                 EFCAB5 
                 −1.157 
                 2.790 
                 −4.749 
                 0.000 
                 0.002 
                 2.551 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000179344 
                 HLA-DQB1 
                 −1.160 
                 6.280 
                 −3.352 
                 0.002 
                 0.025 
                 −1.339 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000109861 
                 CTSC 
                 −1.161 
                 8.068 
                 −3.166 
                 0.003 
                 0.034 
                 −1.882 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138613 
                 APH1B 
                 −1.162 
                 4.311 
                 −4.190 
                 0.000 
                 0.006 
                 0.968 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000216490 
                 IFI30 
                 −1.168 
                 6.374 
                 −3.997 
                 0.000 
                 0.008 
                 0.383 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000122986 
                 HVCN1 
                 −1.169 
                 3.889 
                 −3.400 
                 0.001 
                 0.023 
                 −1.166 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000184922 
                 FMNL1 
                 −1.177 
                 6.217 
                 −4.636 
                 0.000 
                 0.003 
                 2.229 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136286 
                 MYO1G 
                 −1.180 
                 5.435 
                 −3.689 
                 0.001 
                 0.013 
                 −0.440 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000140368 
                 PSTPIP1 
                 −1.180 
                 4.421 
                 −2.955 
                 0.005 
                 0.048 
                 −2.265 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000107738 
                 C100rf54 
                 −1.184 
                 6.132 
                 −3.734 
                 0.001 
                 0.012 
                 −0.323 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000074266 
                 EED 
                 −1.185 
                 4.950 
                 −3.675 
                 0.001 
                 0.014 
                 −0.446 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000129467 
                 ADCY4 
                 −1.187 
                 4.374 
                 −3.258 
                 0.002 
                 0.029 
                 −1.502 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000090104 
                 RGS1 
                 −1.191 
                 7.501 
                 −3.232 
                 0.002 
                 0.031 
                 −1.708 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000141480 
                 ARRB2 
                 −1.193 
                 5.844 
                 −5.017 
                 0.000 
                 0.002 
                 3.368 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000086730 
                 LAT2 
                 −1.194 
                 5.132 
                 −3.052 
                 0.004 
                 0.042 
                 −2.066 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103187 
                 COTL1 
                 −1.194 
                 6.738 
                 −4.410 
                 0.000 
                 0.004 
                 1.556 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000175567 
                 UCP2 
                 −1.195 
                 5.557 
                 −3.289 
                 0.002 
                 0.028 
                 −1.487 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000115525 
                 ST3GAL5 
                 −1.195 
                 4.626 
                 −3.774 
                 0.001 
                 0.012 
                 −0.170 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172183 
                 ISG20 
                 −1.196 
                 6.178 
                 −3.722 
                 0.001 
                 0.013 
                 −0.404 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135678 
                 CPM 
                 −1.197 
                 5.991 
                 −3.171 
                 0.003 
                 0.034 
                 −1.774 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163453 
                 IGFBP7 
                 −1.199 
                 7.045 
                 −4.389 
                 0.000 
                 0.005 
                 1.484 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000113742 
                 CPEB4 
                 −1.201 
                 6.574 
                 −3.750 
                 0.001 
                 0.012 
                 −0.291 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185201 
                 IFITM2 
                 −1.201 
                 4.765 
                 −3.573 
                 0.001 
                 0.016 
                 −0.712 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168010 
                 ATG16L2 
                 −1.204 
                 6.296 
                 −5.262 
                 0.000 
                 0.001 
                 4.109 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000111679 
                 PTPN6 
                 −1.204 
                 5.799 
                 −3.611 
                 0.001 
                 0.015 
                 −0.666 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000002933 
                 TMEM176A 
                 −1.207 
                 4.062 
                 −4.146 
                 0.000 
                 0.006 
                 0.846 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000240583 
                 AQP1 
                 −1.208 
                 5.353 
                 −3.079 
                 0.004 
                 0.040 
                 −1.997 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000105643 
                 ARRDC2 
                 −1.209 
                 5.605 
                 −3.884 
                 0.000 
                 0.010 
                 0.069 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000153071 
                 DAB2 
                 −1.211 
                 6.322 
                 −3.739 
                 0.001 
                 0.012 
                 −0.349 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000134954 
                 ETS1 
                 −1.215 
                 8.326 
                 −4.769 
                 0.000 
                 0.002 
                 2.602 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000153208 
                 MERTK 
                 −1.215 
                 5.186 
                 −3.269 
                 0.002 
                 0.029 
                 −1.507 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143851 
                 PTPN7 
                 −1.219 
                 5.008 
                 −3.552 
                 0.001 
                 0.017 
                 −0.793 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000171608 
                 PIK3CD 
                 −1.223 
                 6.149 
                 −4.000 
                 0.000 
                 0.008 
                 0.377 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198502 
                 HLA-DRB5 
                 −1.224 
                 5.465 
                 −3.435 
                 0.001 
                 0.021 
                 −1.084 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000167323 
                 STIM1 
                 −1.226 
                 6.876 
                 −3.230 
                 0.002 
                 0.031 
                 −1.702 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000081320 
                 STK17B 
                 −1.227 
                 7.868 
                 −4.402 
                 0.000 
                 0.004 
                 1.508 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100100 
                 PIK3IP1 
                 −1.233 
                 6.385 
                 −3.028 
                 0.004 
                 0.043 
                 −2.180 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000066336 
                 SPI1 
                 −1.234 
                 4.610 
                 −4.256 
                 0.000 
                 0.006 
                 1.148 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000069424 
                 KCNAB2 
                 −1.236 
                 5.933 
                 −3.962 
                 0.000 
                 0.009 
                 0.297 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160219 
                 GAB3 
                 −1.237 
                 4.005 
                 −4.908 
                 0.000 
                 0.002 
                 3.023 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000175489 
                 LRRC25 
                 −1.239 
                 3.420 
                 −5.032 
                 0.000 
                 0.002 
                 3.370 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000161638 
                 ITGA5 
                 −1.240 
                 7.393 
                 −2.973 
                 0.005 
                 0.047 
                 −2.347 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101194 
                 SLC17A9 
                 −1.240 
                 4.676 
                 −3.189 
                 0.003 
                 0.033 
                 −1.709 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198909 
                 MAP3K3 
                 −1.247 
                 5.826 
                 −5.865 
                 0.000 
                 0.000 
                 5.958 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000120899 
                 PTK2B 
                 −1.249 
                 6.900 
                 −4.433 
                 0.000 
                 0.004 
                 1.617 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101265 
                 RASSF2 
                 −1.259 
                 6.133 
                 −3.078 
                 0.004 
                 0.040 
                 −2.040 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000099998 
                 GGT5 
                 −1.261 
                 5.447 
                 −3.004 
                 0.005 
                 0.045 
                 −2.157 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000155465 
                 SLC7A7 
                 −1.264 
                 4.553 
                 −4.455 
                 0.000 
                 0.004 
                 1.714 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136205 
                 TN53 
                 −1.268 
                 7.632 
                 −5.069 
                 0.000 
                 0.001 
                 3.515 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000241978 
                 AKAP2 
                 −1.269 
                 6.986 
                 −3.887 
                 0.000 
                 0.010 
                 0.028 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000140030 
                 GPR65 
                 −1.272 
                 3.563 
                 −3.945 
                 0.000 
                 0.009 
                 0.296 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000149564 
                 ESAM 
                 −1.275 
                 3.323 
                 −3.665 
                 0.001 
                 0.014 
                 −0.455 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000257017 
                 HP 
                 −1.275 
                 2.639 
                 −2.972 
                 0.005 
                 0.047 
                 −2.165 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000106565 
                 TMEM176B 
                 −1.279 
                 4.520 
                 −4.538 
                 0.000 
                 0.004 
                 1.953 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135047 
                 CTSL 
                 −1.281 
                 5.471 
                 −4.089 
                 0.000 
                 0.007 
                 0.668 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000158717 
                 RNF166 
                 −1.282 
                 5.196 
                 −4.180 
                 0.000 
                 0.006 
                 0.924 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000110031 
                 LPXN 
                 −1.282 
                 4.750 
                 −3.752 
                 0.001 
                 0.012 
                 −0.237 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000105538 
                 RASIP1 
                 −1.288 
                 3.235 
                 −3.810 
                 0.000 
                 0.011 
                 −0.064 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173200 
                 PARP15 
                 −1.289 
                 7.023 
                 −4.093 
                 0.000 
                 0.007 
                 0.616  
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000010610 
                 CD4 
                 −1.291 
                 5.993 
                 −3.641 
                 0 001 
                 0.015 
                 −0.594 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000149781 
                 FERMT3 
                 −1.292 
                 4.948 
                 −4.329 
                 0.000 
                 0.005 
                 1 345 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135077 
                 HAVCR2 
                 −1.303 
                 5.005 
                 −4.712 
                 0.000 
                 0.003 
                 2.460 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000110934 
                 BIN2 
                 −1.303 
                 4.508 
                 −3.008 
                 0.004 
                 0.045 
                 −2.114 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000150867 
                 PIP4K2A 
                 −1.303 
                 6.207 
                 −4.553 
                 0.000 
                 0.003 
                 1.991 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000155849 
                 ELMO1 
                 −1.304 
                 5.964 
                 −4.039 
                 0.000 
                 0.008 
                 0.493 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000153283 
                 CD96 
                 −1.305 
                 4.602 
                 −3.257 
                 0.002 
                 0.029 
                 −1.522 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136541 
                 ERMN 
                 −1.305 
                 2.728 
                 −3.525 
                 0.001 
                 0.018 
                 −0.816 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000117643 
                 MAN1C1 
                 −1.308 
                 4.603 
                 −3.904 
                 0.000 
                 0.009 
                 0.159 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000213654 
                 GPSM3 
                 −1.309 
                 4.580 
                 −3.642 
                 0.001 
                 0.015 
                 −0.534 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000051108 
                 HERPUD1 
                 −1.311 
                 6.974 
                 −3.795 
                 0.000 
                 0.011 
                 −0.198 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164330 
                 EBF1 
                 −1.319 
                 4.908 
                 −4.246 
                 0.000 
                 0.006 
                 1.123 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162645 
                 GBP2 
                 −1.325 
                 5.772 
                 −3.096 
                 0.004 
                 0.039 
                 −1.952 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104814 
                 MAP4K1 
                 −1.325 
                 4.835 
                 −3.127 
                 0.003 
                 0.037 
                 −1.865 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172578 
                 KLHL6 
                 −1.325 
                 6.365 
                 −3.865 
                 0.000 
                 0.010 
                 0.007 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000084070 
                 SMAP2 
                 −1.333 
                 7.092 
                 −3.903 
                 0.000 
                 0.009 
                 0.092 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000204257 
                 HLA-DMA 
                 −1.335 
                 5.557 
                 −4.029 
                 0.000 
                 0.008 
                 0.504 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000145703 
                 IQGAP2 
                 −1.335 
                 5.472 
                 −3.639 
                 0.001 
                 0.015 
                 −0.557 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000051523 
                 CYBA 
                 −1.338 
                 6.100 
                 −4.997 
                 0.000 
                 0.002 
                 3.308 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000114166 
                 KAT2B 
                 −1.339 
                 5.467 
                 −4.341 
                 0.000 
                 0.005 
                 1.387 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000000938 
                 FGR 
                 −1.341 
                 4.403 
                 −3.119 
                 0.003 
                 0.037 
                 −1.860 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185862 
                 EVI2B 
                 −1.343 
                 5.092 
                 −3.898 
                 0.000 
                 0.009 
                 0.142 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000111348 
                 ARHGDIB 
                 −1.345 
                 6.685 
                 −3.988 
                 0.000 
                 0.008 
                 0.342 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130775 
                 THEMIS2 
                 −1.346 
                 6.274 
                 −3.741 
                 0.001 
                 0.012 
                 −0.316 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000140678 
                 ITGAX 
                 −1.348 
                 6.568 
                 −3.385 
                 0.002 
                 0.023 
                 −1.293 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000231389 
                 HLA-DPA1 
                 −1.352 
                 7.688 
                 −4.204 
                 0.000 
                 0.006 
                 0.934 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163219 
                 ARHGAP25 
                 −1.353 
                 5.145 
                 −4.223 
                 0.000 
                 0.006 
                 1.040 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196735 
                 HLA-DQA1 
                 −1.353 
                 6.399 
                 −3.267 
                 0.002 
                 0.029 
                 −1.541 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163359 
                 COL6A3 
                 −1.354 
                 10.354 
                 −3.159 
                 0.003 
                 0.035 
                 −1.888 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000010327 
                 STAB1 
                 −1.356 
                 7.455 
                 −3.445 
                 0.001 
                 0.021 
                 −1.157 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000174130 
                 TLR6 
                 −1.357 
                 5.014 
                 −4.422 
                 0.000 
                 0.004 
                 1.616 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000128052 
                 KDR 
                 −1.363 
                 4.276 
                 −3.648 
                 0.001 
                 0.014 
                 −0.533 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168071 
                 CCDC88B 
                 −1.364 
                 6.283 
                 −3.838 
                 0.000 
                 0.010 
                 −0.072 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000126785 
                 RHOJ 
                 −1.365 
                 3.907 
                 −3.191 
                 0.003 
                 0.033 
                 −1.674 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000154217 
                 PITPNC1 
                 −1.368 
                 5.134 
                 −6.029 
                 0.000 
                 0.000 
                 6.430 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000010295 
                 IFFO1 
                 −1.369 
                 4.508 
                 −4.462 
                 0.000 
                 0.004 
                 1.737 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000159733 
                 ZFYVE28 
                 −1.373 
                 3.826 
                 −4.085 
                 0.000 
                 0.007 
                 0.677 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000011600 
                 TYROBP 
                 −1.377 
                 3.824 
                 −4.188 
                 0.000 
                 0.006 
                 0.961 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100219 
                 XBP1 
                 −1.377 
                 7.426 
                 −3.081 
                 0.004 
                 0.040 
                 −2.085 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000181896 
                 ZNF101 
                 −1.378 
                 6.042 
                 −3.185 
                 0.003 
                 0.033 
                 −1.788 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000131378 
                 RFTN1 
                 −1.379 
                 6.038 
                 −4.490 
                 0.000 
                 0.004 
                 1.800 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000127329 
                 PTPRB 
                 −1.384 
                 5.478 
                 −4.395 
                 0.000 
                 0.004 
                 1.523 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000123338 
                 NCKAP1L 
                 −1.386 
                 6.793 
                 −4.626 
                 0.000 
                 0.003 
                 2.187 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000148516 
                 ZEB1 
                 −1.386 
                 5.941 
                 −3.889 
                 0.000 
                 0.010 
                 0.086 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000149054 
                 ZNF215 
                 −1.389 
                 2.944 
                 −3.183 
                 0.003 
                 0.033 
                 −1.664 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000182568 
                 SATB1 
                 −1.390 
                 6.057 
                 −3.520 
                 0.001 
                 0.018 
                 −0.929 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000154814 
                 OXNAD1 
                 −1.390 
                 5.352 
                 −4.715 
                 0.000 
                 0.003 
                 2.467 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101082 
                 SLA2 
                 −1.390 
                 3.573 
                 −3.760 
                 0.001 
                 0.012 
                 −0.213 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196126 
                 HLA-DRB1 
                 −1.390 
                 7.074 
                 −4.043 
                 0.000 
                 0.008 
                 0.505 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000184060 
                 ADAP2 
                 −1.400 
                 4.480 
                 −3.954 
                 0.000 
                 0.009 
                 0.314 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000164674 
                 SYTL3 
                 −1.400 
                 4.341 
                 −3.037 
                 0.004 
                 0.043 
                 −2.058 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000158869 
                 FCER1G 
                 −1.402 
                 4.294 
                 −4.045 
                 0.000 
                 0.008 
                 0.565 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000091490 
                 SEL1L3 
                 −1.409 
                 6.742 
                 −3.615 
                 0.001 
                 0.015 
                 −0.698 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196209 
                 SIRPB2 
                 −1.411 
                 3.345 
                 −3.478 
                 0.001 
                 0.020 
                 −0.940 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000184497 
                 TMEM255B 
                 −1.411 
                 3.912 
                 −3.612 
                 0.001 
                 0.015 
                 −0.602 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000179776 
                 CDH5 
                 −1.411 
                 4.453 
                 −3.000 
                 0.005 
                 0.045 
                 −2.151 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000159640 
                 ACE 
                 −1.411 
                 4.406 
                 −3.322 
                 0.002 
                 0.026 
                 −1.356 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000178199 
                 ZC3H12D 
                 −1.412 
                 5.381 
                 −3.574 
                 0.001 
                 0.016 
                 −0.748 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000101096 
                 NFATC2 
                 −1.413 
                 6.151 
                 −3.205 
                 0.003 
                 0.032 
                 −1.740 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000105609 
                 LILRB5 
                 −1.415 
                 3.526 
                 −2.942 
                 0.005 
                 0.049 
                 −2.255 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130830 
                 MPP1 
                 −1.416 
                 4.241 
                 −4.456 
                 0.000 
                 0.004 
                 1.718 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130653 
                 PNPLA7 
                 −1.420 
                 4.295 
                 −3.631 
                 0.001 
                 0.015 
                 −0.559 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000133392 
                 MYH11 
                 −1.423 
                 6.163 
                 −3.087 
                 0.004 
                 0.039 
                 −2.048 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000146826 
                 C7orf43 
                 −1.423 
                 5.137 
                 −3.172 
                 0.003 
                 0.034 
                 −1.819 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000223865 
                 HLA-DPB1 
                 −1.427 
                 6.980 
                 −4.237 
                 0.000 
                 0.006 
                 1.046 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000078237 
                 TIGAR 
                 −1.435 
                 4.361 
                 −2.978 
                 0.005 
                 0.047 
                 −2.210 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185477 
                 GPRIN3 
                 −1.436 
                 6.767 
                 −4.515 
                 0.000 
                 0.004 
                 1.848 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000072786 
                 STK10 
                 −1.442 
                 6.579 
                 −6.890 
                 0.000 
                 0.000 
                 9.126 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000007237 
                 GAS7 
                 −1.443 
                 5.701 
                 −3.849 
                 0.000 
                 0.010 
                 −0.023 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104714 
                 ERICH1 
                 −1.445 
                 5.889 
                 −4.960 
                 0.000 
                 0.002 
                 3.185 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000111860 
                 CEP85L 
                 −1.445 
                 5.181 
                 −5.119 
                 0.000 
                 0.001 
                 3.672 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000176928 
                 GCNT4 
                 −1.451 
                 3.522 
                 −3.230 
                 0.002 
                 0.031 
                 −1.572 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000134830 
                 C5AR2 
                 −1.451 
                 4.874 
                 −3.968 
                 0.000 
                 0.009 
                 0.329 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000126882 
                 FAM78A 
                 −1.454 
                 4.841 
                 −3.584 
                 0.001 
                 0.016 
                 −0.392 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163568 
                 AIM2 
                 −1.458 
                 3.740 
                 −3.710 
                 0.001 
                 0.013 
                 −0.334 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000076641 
                 PAG1 
                 −1.465 
                 6.732 
                 −4.691 
                 0.000 
                 0.003 
                 2.380 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000115956 
                 PLEK 
                 −1.466 
                 5.488 
                 −3.401 
                 0.002 
                 0.023 
                 −1.193 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000180448 
                 ARHGAP45 
                 −1.477 
                 6.594 
                 −3.961 
                 0.000 
                 0.009 
                 0.260 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138134 
                 STAMBPL1 
                 −1.482 
                 4.427 
                 −4.076 
                 0.000 
                 0.007 
                 0.637 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000155307 
                 SAMSN1 
                 −1.486 
                 4.594 
                 −3.929 
                 0.000 
                 0.009 
                 0.231 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000170571 
                 EMB 
                 −1.486 
                 6.398 
                 −4.312 
                 0.000 
                 0.005 
                 1.281 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000110876 
                 SELPLG 
                 −1.491 
                 4.647 
                 −4.097 
                 0.000 
                 0.007 
                 0.699 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162618 
                 ADGRL4 
                 −1.494 
                 3.411 
                 −3.851 
                 0.000 
                 0.010 
                 0.043 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198440 
                 ZNF583 
                 −1.496 
                 3.358 
                 −4.123 
                 0.000 
                 0.007 
                 0.761 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000107968 
                 MAP3K8 
                 −1.498 
                 4.960 
                 −3.687 
                 0.001 
                 0.013 
                 −0.423 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000115232 
                 ITGA4 
                 −1.500 
                 5.797 
                 −3.770 
                 0.001 
                 0.012 
                 −0.228 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000180353 
                 HCLS1 
                 −1.503 
                 6.474 
                 −4.215 
                 0.000 
                 0.006 
                 0.991 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000141338 
                 ABCA8 
                 −1.504 
                 3.217 
                 −2.972 
                 0.005 
                 0.047 
                 −2.170 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000146070 
                 PLA2G7 
                 −1.510 
                 3.797 
                 −4.125 
                 0.000 
                 0.007 
                 0.784 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000271503 
                 CCL5 
                 −1.511 
                 4.877 
                 −4.271 
                 0.000 
                 0.006 
                 1.183 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000169744 
                 LDB2 
                 −1.513 
                 3.759 
                 −4.115 
                 0.000 
                 0.007 
                 0.757 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000151067 
                 CACNA1C 
                 −1.519 
                 4.975 
                 −3.172 
                 0.003 
                 0.034 
                 −1.765 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135709 
                 KIAA0513 
                 −1.520 
                 5.999 
                 −4.113 
                 0.000 
                 0.007 
                 0.738 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000079215 
                 SLC1A3 
                 −1.521 
                 5.467 
                 −3.458 
                 0.001 
                 0.021 
                 −1.033 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000160255 
                 ITGB2 
                 −1.524 
                 6.600 
                 −4.370 
                 0.000 
                 0.005 
                 1.437 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000167895 
                 TMC8 
                 −1.524 
                 6.024 
                 −3.383 
                 0.002 
                 0.024 
                 −1.283 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000124126 
                 PREX1 
                 −1.524 
                 6.531 
                 −4.974 
                 0.000 
                 0.002 
                 3.226 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104894 
                 CD37 
                 −1.529 
                 5.981 
                 −3.191 
                 0.003 
                 0.033 
                 −1.770 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000204287 
                 HLA-DRA 
                 −1.534 
                 8.392 
                 −4.823 
                 0.000 
                 0.002 
                 2.758 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000174059 
                 CD34 
                 −1.534 
                 4.740 
                 −3.107 
                 0.003 
                 0.038 
                 −1.874 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000113532 
                 ST8SIA4 
                 −1.537 
                 5.509 
                 −4.469 
                 0.000 
                 0.004 
                 1.743 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000043462 
                 LCP2 
                 −1.538 
                 5.996 
                 −4.946 
                 0.000 
                 0.002 
                 3.149 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000107551 
                 RASSF4 
                 −1.538 
                 6.337 
                 −4.225 
                 0.000 
                 0.006 
                 1.034 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000028137 
                 TNFRSF1B 
                 −1.540 
                 6.371 
                 −3.577 
                 0.001 
                 0.016 
                 −0.787 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166250 
                 CLMP 
                 −1.548 
                 5.567 
                 −3.491 
                 0.001 
                 0.019 
                 −0.934 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163513 
                 TGFBR2 
                 −1.551 
                 7.259 
                 −5.361 
                 0.000 
                 0.001 
                 4.404 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136250 
                 AOAH 
                 −1.552 
                 4.430 
                 −4.132 
                 0.000 
                 0.007 
                 0.796 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000165168 
                 CYBB 
                 −1.554 
                 6.904 
                 −4.468 
                 0.000 
                 0.004 
                 1.732 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000188906 
                 LRRK2 
                 −1.555 
                 5.285 
                 −3.713 
                 0.001 
                 0.013 
                 −0.366 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000023171 
                 GRAMD1B 
                 −1.556 
                 4.403 
                 −3.863 
                 0.000 
                 0.010 
                 0.055 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125354 
                 SEPT6 
                 −1.561 
                 6.122 
                 −4.316 
                 0.000 
                 0.005 
                 1.287 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000163131 
                 CTSS 
                 −1.563 
                 6.658 
                 −4.294 
                 0.000 
                 0.005 
                 1.228 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000123329 
                 ARHGAP9 
                 −1.569 
                 5.244 
                 −2.951 
                 0.005 
                 0.048 
                 −2.287 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000157514 
                 TSC22D3 
                 −1.571 
                 7.754 
                 −4.063 
                 0.000 
                 0.007 
                 0.550 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000072818 
                 ACAP1 
                 −1.574 
                 6.160 
                 −4.513 
                 0.000 
                 0.004 
                 1.858 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000013725 
                 CD6 
                 −1.574 
                 5.043 
                 −3.327 
                 0.002 
                 0.026 
                 −1.373 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000154127 
                 UBASH3B 
                 −1.575 
                 5.263 
                 −4.906 
                 0.000 
                 0.002 
                 3.029 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000107099 
                 DOCK8 
                 −1.576 
                 7.251 
                 −4.449 
                 0.000 
                 0.004 
                 1.657 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000122122 
                 SASH3 
                 −1.578 
                 4.957 
                 −3.371 
                 0.002 
                 0.024 
                 −1.247 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197249 
                 SERPINA1 
                 −1.582 
                 4.599 
                 −3.260 
                 0.002 
                 0.029 
                 −1.508 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000115165 
                 CYTIP 
                 −1.583 
                 5.726 
                 −3.506 
                 0.001 
                 0.019 
                 −0.922 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000158517 
                 NCF1 
                 −1.584 
                 4.067 
                 −3.573 
                 0.001 
                 0.017 
                 −0.710 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000055163 
                 CYFIP2 
                 −1.584 
                 5.674 
                 −3.225 
                 0.002 
                 0.031 
                 −1.655 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000159189 
                 C1QC 
                 −1.590 
                 5.953 
                 −3.923 
                 0.000 
                 0.009 
                 0.199 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168685 
                 IL7R 
                 −1.592 
                 7.463 
                 −4.384 
                 0.000 
                 0.005 
                 1.461 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000204252 
                 HLA-DOA 
                 −1.595 
                 5.489 
                 −3.005 
                 0.005 
                 0.045 
                 −2.186 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198771 
                 RCSD1 
                 −1.595 
                 5.765 
                 −4.288 
                 0.000 
                 0.005 
                 1.204 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000102575 
                 ACP5 
                 −1.605 
                 5.001 
                 −4.330 
                 0.000 
                 0.005 
                 1.351 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166278 
                 C2 
                 −1.610 
                 5.364 
                 −4.026 
                 0.000 
                 0.008 
                 0.498 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000033327 
                 GAB2 
                 −1.611 
                 5.449 
                 −4.676 
                 0.000 
                 0.003 
                 2.345 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172572 
                 PDE3A 
                 −1.612 
                 4.914 
                 −3.906 
                 0.000 
                 0.009 
                 0.154 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172349 
                 IL16 
                 −1.614 
                 6.119 
                 −3.723 
                 0.001 
                 0.013 
                 −0.382 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000009790 
                 TRAF3IP3 
                 −1.617 
                 5.648 
                 −3.401 
                 0.002 
                 0.023 
                 −1.203 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130203 
                 APOE 
                 −1.618 
                 6.301 
                 −3.830 
                 0.000 
                 0.011 
                 −0.071 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104903 
                 LYL1 
                 −1.619 
                 3.187 
                 −4.479 
                 0.000 
                 0.004 
                 1.779 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000170458 
                 CD14 
                 −1.619 
                 4.771 
                 −3.944 
                 0.000 
                 0.009 
                 0.273 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000242574 
                 HLA-DMB 
                 −1.620 
                 6.042 
                 −4.700 
                 0.000 
                 0.003 
                 2.414 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000019582 
                 CD74 
                 −1.627 
                 10.000 
                 −5.365 
                 0.000 
                 0.001 
                 4.404 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000129226 
                 CD68 
                 −1.628 
                 6.067 
                 −4.523 
                 0.000 
                 0.004 
                 1.901 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000172215 
                 CXCR6 
                 −1.629 
                 3.773 
                 −5.709 
                 0.000 
                 0.001 
                 5.381 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000127528 
                 KLF2 
                 −1.634 
                 5.222 
                 −2.936 
                 0.005 
                 0.049 
                 −2.329 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000147168 
                 IL2RG 
                 −1.638 
                 4.862 
                 −4.182 
                 0.000 
                 0.006 
                 0.930 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130475 
                 FCHO1 
                 −1.643 
                 3.866 
                 −5.198 
                 0.000 
                 0.001 
                 3.886 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000261371 
                 PECAM1 
                 −1.644 
                 6.787 
                 −5.983 
                 0.000 
                 0.000 
                 6.316 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000151702 
                 FLI1 
                 −1.653 
                 5.747 
                 −5.204 
                 0.000 
                 0.001 
                 3.922 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000125810 
                 CD93 
                 −1.653 
                 6.515 
                 −5.218 
                 0.000 
                 0.001 
                 3.961 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000122862 
                 SRGN 
                 −1.653 
                 6.383 
                 −5.341 
                 0.000 
                 0.001 
                 4.336 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000075884 
                 ARHGAP15 
                 −1.654 
                 5.701 
                 −3.609 
                 0.001 
                 0.015 
                 −0.656 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000131018 
                 SYNE1 
                 −1.663 
                 7.671 
                 −6.146 
                 0.000 
                 0.000 
                 6.832 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173369 
                 C1QB 
                 −1.667 
                 5.963 
                 −3.670 
                 0.001 
                 0.014 
                 −0.483 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000182183 
                 FAM159A 
                 −1.668 
                 3.510 
                 −3.887 
                 0.000 
                 0.010 
                 0.125 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000149131 
                 SERPING1 
                 −1.668 
                 6.271 
                 −3.763 
                 0.001 
                 0.012 
                 −0.228 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000074966 
                 TXK 
                 −1.669 
                 3.750 
                 −3.084 
                 0.004 
                 0.040 
                 −1.925 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000113263 
                 ITK 
                 −1.670 
                 6.134 
                 −3.261 
                 0.002 
                 0.029 
                 −1.594 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135905 
                 DOCK10 
                 −1.672 
                 6.688 
                 −4.819 
                 0.000 
                 0.002 
                 2.758 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000174600 
                 CMKLR1 
                 −1.673 
                 4.770 
                 −3.895 
                 0.000 
                 0.010 
                 0.146 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000149591 
                 TAGLN 
                 −1.676 
                 6.751 
                 −3.317 
                 0.002 
                 0.026 
                 −1.491 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000102879 
                 CORO1A 
                 −1.691 
                 6.289 
                 −3.264 
                 0.002 
                 0.029 
                 −1.580 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000177575 
                 CD163 
                 −1.697 
                 6.905 
                 −3.298 
                 0.002 
                 0.027 
                 −1.471 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000250722 
                 SEPP1 
                 −1.709 
                 6.223 
                 −2.962 
                 0.005 
                 0.047 
                 −2.332 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000175899 
                 A2M 
                 −1.709 
                 7.554 
                 −5.300 
                 0.000 
                 0.001 
                 4.206 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166741 
                 NNMT 
                 −1.709 
                 5.332 
                 −3.083 
                 0.004 
                 0.040 
                 −1.963 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137801 
                 THBS1 
                 −1.715 
                 9.562 
                 −3.468 
                 0.001 
                 0.020 
                 −1.103 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000161405 
                 IKZF3 
                 −1.717 
                 7.038 
                 −3.707 
                 0.001 
                 0.013 
                 −0.440 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000077238 
                 IL4R 
                 −1.719 
                 7.293 
                 −4.881 
                 0.000 
                 0.002 
                 2.934 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000185989 
                 RASA3 
                 −1.726 
                 5.993 
                 −5.793 
                 0.000 
                 0.000 
                 5.717 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000179583 
                 CIITA 
                 −1.740 
                 7.843 
                 −4.243 
                 0.000 
                 0.006 
                 1.043 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000100055 
                 CYTH4 
                 −1.747 
                 5.662 
                 −5.902 
                 0.000 
                 0.000 
                 6.045 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000169554 
                 ZEB2 
                 −1.751 
                 7.836 
                 −4.719 
                 0.000 
                 0.003 
                 2.440 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000116016 
                 EPAS1 
                 −1.751 
                 7.912 
                 −8.279 
                 0.000 
                 0.000 
                 13.305 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000128815 
                 WDFY4 
                 −1.755 
                 4.967 
                 −3.297 
                 0.002 
                 0.027 
                 −1.432 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000171860 
                 C3AR1 
                 −1.759 
                 3.620 
                 −4.083 
                 0.000 
                 0.007 
                 0.664 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000104972 
                 LILRB1 
                 −1.767 
                 4.493 
                 −4.401 
                 0.000 
                 0.004 
                 1.546 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000171115 
                 GIMAP8 
                 −1.774 
                 4.344 
                 −5.332 
                 0.000 
                 0.001 
                 4.265 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000081237 
                 PTPRC 
                 −1.777 
                 7.711 
                 −4.243 
                 0.000 
                 0.006 
                 1.050 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000135636 
                 DYSF 
                 −1.795 
                 5.415 
                 −3.816 
                 0.000 
                 0.011 
                 −0.074 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000155926 
                 SLA 
                 −1.799 
                 6.359 
                 −4.873 
                 0.000 
                 0.002 
                 2.919 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000117009 
                 KMO 
                 −1.800 
                 3.867 
                 −3.269 
                 0.002 
                 0.029 
                 −1.467 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000113749 
                 HRH2 
                 −1.801 
                 3.722 
                 −3.494 
                 0.001 
                 0.019 
                 −0.900 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197943 
                 PLCG2 
                 −1.807 
                 5.984 
                 −3.790 
                 0.000 
                 0.011 
                 −0.171 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000146094 
                 DOK3 
                 −1.813 
                 4.438 
                 −4.657 
                 0.000 
                 0.003 
                 2.285 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000139567 
                 ACVRL1 
                 −1.814 
                 4.570 
                 −5.678 
                 0.000 
                 0.001 
                 5.301 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000158714 
                 SLAMF8 
                 −1.820 
                 4.665 
                 −4.737 
                 0.000 
                 0.003 
                 2.512 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137033 
                 IL33 
                 −1.826 
                 4.084 
                 −3.132 
                 0.003 
                 0.037 
                 −1.829 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000072694 
                 FCGR2B 
                 −1.835 
                 4.904 
                 −4.037 
                 0.000 
                 0.008 
                 0.529 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000026751 
                 SLAMF7 
                 −1.835 
                 4.997 
                 −3.091 
                 0.004 
                 0.039 
                 −1.927 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000121904 
                 CSMD2 
                 −1.837 
                 3.400 
                 −3.130 
                 0.003 
                 0.037 
                 −1.815 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000157110 
                 RBPMS 
                 −1.838 
                 5.558 
                 −3.877 
                 0.000 
                 0.010 
                 0.053 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000090382 
                 LYZ 
                 −1.844 
                 7.279 
                 −4.074 
                 0.000 
                 0.007 
                 0.575 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000167613 
                 LAIR1 
                 −1.850 
                 5.707 
                 −5.346 
                 0.000 
                 0.001 
                 4.337 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000186818 
                 LILRB4 
                 −1.851 
                 4.655 
                 −4.506 
                 0.000 
                 0.004 
                 1.849 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000082074 
                 FYB 
                 −1.855 
                 6.661 
                 −4.249 
                 0.000 
                 0.006 
                 1.098 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000115523 
                 GNLY 
                 −1.858 
                 3.611 
                 −3.996 
                 0.000 
                 0.008 
                 0.425 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000168918 
                 INPP5D 
                 −1.860 
                 6.562 
                 −3.895 
                 0.000 
                 0.010 
                 0.105 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000005844 
                 ITGAL 
                 −1.870 
                 5.812 
                 −3.713 
                 0.001 
                 0.013 
                 −0.370 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000198959 
                 TGM2 
                 −1.880 
                 7.010 
                 −4.403 
                 0.000 
                 0.004 
                 1.525 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000131042 
                 LILRB2 
                 −1.881 
                 3.751 
                 −4.142 
                 0.000 
                 0.007 
                 0.825 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000146192 
                 FGD2 
                 −1.894 
                 6.172 
                 −4.822 
                 0.000 
                 0.002 
                 2.770 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000197629 
                 MPEG1 
                 −1.900 
                 6.038 
                 −5.043 
                 0.000 
                 0.002 
                 3.428 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000138964 
                 PARVG 
                 −1.901 
                 5.810 
                 −4.043 
                 0.000 
                 0.008 
                 0.523 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000130755 
                 GMFG 
                 −1.910 
                 4.241 
                 −4.101 
                 0.000 
                 0.007 
                 0.711 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000140968 
                 IRF8 
                 −1.913 
                 5.673 
                 −3.382 
                 0.002 
                 0.024 
                 −1.240 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000134516 
                 DOCK2 
                 −1.915 
                 6.540 
                 −4.254 
                 0.000 
                 0.006 
                 1.119 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000110077 
                 MS4A6A 
                 −1.919 
                 5.824 
                 −4.836 
                 0.000 
                 0.002 
                 2.810 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137491 
                 SLCO2B1 
                 −1.926 
                 7.133 
                 −5.577 
                 0.000 
                 0.001 
                 5.042 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000162511 
                 LAPTM5 
                 −1.932 
                 7.971 
                 −5.776 
                 0.000 
                 0.001 
                 5.664 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000133574 
                 GIMAP4 
                 −1.951 
                 4.506 
                 −4.377 
                 0.000 
                 0.005 
                 1.482 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000259207 
                 ITGB3 
                 −1.958 
                 3.076 
                 −3.515 
                 0.001 
                 0.019 
                 −0.842 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000141506 
                 PIK3R5 
                 −1.963 
                 5.404 
                 −4.198 
                 0.000 
                 0.006 
                 0.968 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143226 
                 FCGR2A 
                 −1.966 
                 5.987 
                 −4.109 
                 0.000 
                 0.007 
                 0.724 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000166927 
                 MS4A7 
                 −1.968 
                 5.592 
                 −4.062 
                 0.000 
                 0.007 
                 0.588 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000173372 
                 C1QA 
                 −1.969 
                 5.769 
                 −4.221 
                 0.000 
                 0.006 
                 1.037 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000137841 
                 PLCB2 
                 −2.006 
                 5.407 
                 −4.278 
                 0.000 
                 0.006 
                 1.201 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000283652 
                 WDFY4 
                 −2.016 
                 5.915 
                 −3.567 
                 0.001 
                 0.017 
                 −0.772 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000143119 
                 CD53 
                 −2.023 
                 6.129 
                 −4.705 
                 0.000 
                 0.003 
                 2.428 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000066294 
                 CD84 
                 −2.023 
                 6.667 
                 −4.910 
                 0.000 
                 0.002 
                 3.031 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000170989 
                 S1PR1 
                 −2.035 
                 4.546 
                 −4.386 
                 0.000 
                 0.005 
                 1.509 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000127084 
                 FGD3 
                 −2.055 
                 5.444 
                 −3.655 
                 0.001 
                 0.014 
                 −0.529 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000124406 
                 ATP8A1 
                 −2.068 
                 5.412 
                 −3.523 
                 0.001 
                 0.018 
                 −0.848 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000110324 
                 IL10RA 
                 −2.089 
                 6.457 
                 −4.922 
                 0.000 
                 0.002 
                 3.068 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000129538 
                 RNASE1 
                 −2.103 
                 4.986 
                 −2.961 
                 0.005 
                 0.047 
                 −2.208 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000111913 
                 FAM65B 
                 −2.119 
                 6.221 
                 −3.604 
                 0.001 
                 0.016 
                 −0.690 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136960 
                 ENPP2 
                 −2.173 
                 4.829 
                 −5.046 
                 0.000 
                 0.002 
                 3.419 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000103522 
                 IL21R 
                 −2.192 
                 5.182 
                 −3.932 
                 0.000 
                 0.009 
                 0.226 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000144218 
                 AFF3 
                 −2.216 
                 4.918 
                 −3.384 
                 0.002 
                 0.023 
                 −1.245 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000117215 
                 PLA2G2D 
                 −2.287 
                 3.360 
                 −3.213 
                 0.003 
                 0.032 
                 −1.621 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000131016 
                 AKAP12 
                 −2.289 
                 5.954 
                 −3.272 
                 0.002 
                 0.029 
                 −1.544 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000196329 
                 GIMAP5 
                 −2.515 
                 5.025 
                 −5.204 
                 0.000 
                 0.001 
                 3.895 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000203710 
                 CR1 
                 −2.632 
                 4.585 
                 −3.975 
                 0.000 
                 0.009 
                 0.359 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000090659 
                 CD209 
                 −2.731 
                 4.128 
                 −3.788 
                 0.000 
                 0.011 
                 −0.144 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000136869 
                 TLR4 
                 −2.859 
                 5.010 
                 −6.218 
                 0.000 
                 0.000 
                 6.883 
               
               
                 LNM Group 3 vs. Group 1 
                 ENSG00000260314 
                 MRC1 
                 −3.453 
                 5.521 
                 −5.875 
                 0.000 
                 0.000 
                 5.868 
               
               
                 LNM Group 1 vs. Group 2 
                 miRNA 
                 hsa-miR-205-5p 
                 −0.990 
                 15.614 
                 −3.953 
                 0.000 
                 0.083 
                 0.246 
               
               
                 LNM Group 1 vs. Group 2 
                 miRNA 
                 hsa-miR-106a-5p 
                 1.150 
                 3.816 
                 3.753 
                 0.001 
                 0.083 
                 −0.197 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-183-5p 
                 −2.744 
                 10.364 
                 −4.558 
                 0.000 
                 0.014 
                 2.046 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-182-5p 
                 −1.961 
                 13.618 
                 −4.194 
                 0.000 
                 0.018 
                 0.999 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-30a-3p 
                 −1.753 
                 8.004 
                 −4.094 
                 0.000 
                 0.018 
                 0.727 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-877*5p 
                 −1.906 
                 6.713 
                 −3.980 
                 0.000 
                 0.018 
                 0.406 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-30a-5p 
                 −1.507 
                 13.008 
                 −3.962 
                 0.000 
                 0.018 
                 0.351 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-17-5p 
                 −1.488 
                 8.659 
                 −3.806 
                 0.000 
                 0.024 
                 −0.054 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-96-5p 
                 −1.832 
                 5.054 
                 −3.640 
                 0.001 
                 0.031 
                 −0.500 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-30d-5p 
                 −1.099 
                 13.929 
                 −3.615 
                 0.001 
                 0.031 
                 −0.594 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-324-5p 
                 −1.287 
                 7.058 
                 −3.541 
                 0.001 
                 0.035 
                 −0.738 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-92a-3p 
                 −1.157 
                 15.337 
                 −3.359 
                 0.002 
                 0.053 
                 −1.289 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-7706 
                 −1.801 
                 6.906 
                 −3.320 
                 0.002 
                 0.053 
                 −1.284 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-9-5p 
                 −2.206 
                 5.610 
                 −3.175 
                 0.003 
                 0.066 
                 −1.633 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-30b-5p 
                 −0.959 
                 10.547 
                 −3.161 
                 0.003 
                 0.066 
                 −1.713 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-17-3p 
                 −1.492 
                 5.656 
                 −3.160 
                 0.003 
                 0.066 
                 −1.657 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-320a 
                 −1.569 
                 12.671 
                 −3.009 
                 0.004 
                 0.093 
                 −2.110 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-320d 
                 −1.599 
                 5.172 
                 −2.898 
                 0.006 
                 0.099 
                 −2.260 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-421 
                 0.912 
                 7.619 
                 2.890 
                 0.006 
                 0.099 
                 −2.315 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-484 
                 −1.091 
                 9.439 
                 −2.880 
                 0.006 
                 0.099 
                 −2.369 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-324-3p 
                 −0.945 
                 6.581 
                 −2.878 
                 0.006 
                 0.099 
                 −2.330 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-320c 
                 −1.428 
                 6.848 
                 −2.863 
                 0.006 
                 0.099 
                 −2.364 
               
               
                 LNM Group 2 vs. Group 3 
                 miRNA 
                 hsa-miR-125a-5p 
                 −1.108 
                 12.943 
                 −2.860 
                 0.007 
                 0.099 
                 −2.461 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-182-5p 
                 2.673 
                 13.618 
                 5.986 
                 0.000 
                 0.000 
                 6.429 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-183-5p 
                 3.181 
                 10.364 
                 5.527 
                 0.000 
                 0.000 
                 4.986 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-96-5p 
                 2.412 
                 5.054 
                 5.020 
                 0.000 
                 0.001 
                 3.420 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-877-5p 
                 2.080 
                 6.713 
                 4.582 
                 0.000 
                 0.003 
                 2.108 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-30a-3p 
                 1.670 
                 8.004 
                 4.089 
                 0.000 
                 0.012 
                 0.632 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-30a-5p 
                 1.437 
                 13.008 
                 3.952 
                 0.000 
                 0.015 
                 0.163 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-324-5p 
                 1.226 
                 7.058 
                 3.551 
                 0.001 
                 0.036 
                 −0.826 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-324-3p 
                 1.106 
                 6.581 
                 3.549 
                 0.001 
                 0.036 
                 −0.825 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-17-5p 
                 1.321 
                 8.659 
                 3.531 
                 0.001 
                 0.036 
                 −0.925 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-205-5p 
                 1.378 
                 15.614 
                 3.354 
                 0.002 
                 0.053 
                 −1.544 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-30d-5p 
                 0.962 
                 13.929 
                 3.297 
                 0.002 
                 0.055 
                 −1.635 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-143-5p 
                 −1.903 
                 5.030 
                 −3.256 
                 0.002 
                 0.055 
                 −1.499 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-9-5p 
                 2.134 
                 5.610 
                 3.252 
                 0.002 
                 0.055 
                 −1.584 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-7706 
                 1.652 
                 6.906 
                 3.190 
                 0.003 
                 0.061 
                 −1.733 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-320c 
                 1.473 
                 6.848 
                 3.105 
                 0.003 
                 0.072 
                 −1.971 
               
               
                 LNM Group 3 vs. Group 1 
                 miRNA 
                 hsa-miR-320d 
                 1.604 
                 5.172 
                 3.056 
                 0.004 
                 0.077 
                 −2.040 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Accuracy of existing classifiers to predict Group 2 LNM subtype. 
               
            
           
           
               
               
               
               
               
            
               
                   
                 172 gene  
                 30 gene 
                 10 gene RSi 
                 13 gene OSCC  
               
               
                   
                 signature 
                 PI score  
                 (Eschrich  
                 risk score 
               
               
                   
                 (De Cecco  
                 (Enokida  
                 et al. 2000) 
                 (Lohavanichbutr 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 et al. 2014) 
                 et al. 2017) 
                 Non- 
                   
                 et al. 2012) 
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                   
                 High risk 
                 Low risk 
                 PI-high 
                 PI-low 
                 Responder 
                 Responder 
                 High 
                 Low 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 iCluster grouping 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Group 2 
                 18 
                 11 
                 26 
                 3 
                 28 
                 1 
                 25 
                 4 
               
               
                 Group 1&amp;3 
                 17 
                 26 
                 11 
                 32 
                 27 
                 16 
                 11 
                 32 
               
               
                 Sensitivity 
                 0.621  
                 (0.440-0.773) 
                 0.897  
                 (0.736-0.964) 
                 0.966  
                 (0.828-0.994) 
                 0.862 
                 (0.694-0.945) 
               
               
                 Specificity 
                 0.605  
                 (0.456-0.786) 
                 0.744  
                 (0.598-0.851) 
                 0.372 
                 (0.244-0.521) 
                 0.744 
                 (0.598-0.851) 
               
               
                 Positive  
                 0.514  
                 (0.356-0.670) 
                 0.703 
                 (0.542-0.825) 
                 0.509 
                 (0.381-0.636) 
                 0.694 
                 (0.531-0.820) 
               
               
                 predictive 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 value 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Negative  
                 0.703 
                 (0.542-0.825) 
                 0.914 
                 (0.776-0.970) 
                 0.941 
                 (0.730-0.990) 
                 0.889 
                 (0.747-0.956) 
               
               
                 predictive 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 value 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Accuracy 
                 0.611 
                 (0.488-0.724)) 
                 0.806 
                 (0.695-0.889) 
                 0.611 
                 (6.489-0.724) 
                 0.791 
                 (0.679-0.878) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 73 gene classifier 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 prop- 
               
               
                   
                   
                   
                   
                   
                 se- 
               
               
                   
                   
                   
                   
                 av- 
                 lect- 
               
               
                   
                   
                   
                   
                 rank- 
                 ed- 
               
               
                   
                 Gene  
                 C13- 
                 C2- 
                 in- 
                 in- 
               
               
                 Ensemble ID 
                 Name 
                 score 
                 score 
                 CV 
                 CV 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 ENSG00000106799 
                 TGFBR1 
                 −0.1064 
                 0.1596 
                 1.9 
                 1 
               
               
                 ENSG00000173391 
                 OLR1 
                 −0.1062 
                 0.1593 
                 1.7 
                 1 
               
               
                 ENSG00000145431 
                 PDGFC 
                 −0.0974 
                 0.1461 
                 2.9 
                 1 
               
               
                 ENSG00000159640 
                 ACE 
                 −0.0664 
                 0.0995 
                 8.8 
                 1 
               
               
                 ENSG00000174197 
                 MGA 
                 0.066 
                 −0.099 
                 8 
                 1 
               
               
                 ENSG00000182752 
                 PAPPA 
                 −0.0656 
                 0.0984 
                 9.3 
                 1 
               
               
                 ENSG00000163697 
                 APBB2 
                 −0.0591 
                 0.0886 
                 12.5 
                 1 
               
               
                 ENSG00000165233 
                 CARD19 
                 −0.058 
                 0.087 
                 11.2 
                 1 
               
               
                 ENSG00000214300 
                 SPDYE3 
                 0.0546 
                 −0.0819 
                 11.7 
                 1 
               
               
                 ENSG00000123130 
                 ACOT9 
                 −0.0543 
                 0.0815 
                 13.9 
                 1 
               
               
                 ENSG00000133466 
                 C1QTNF6 
                 −0.0474 
                 0.0711 
                 17.9 
                 1 
               
               
                 ENSG00000182230 
                 FAM153B 
                 0.0449 
                 −0.0673 
                 18.4 
                 1 
               
               
                 ENSG00000222047 
                 C10orf55 
                 −0.0446 
                 0.0669 
                 17.9 
                 1 
               
               
                 ENSG00000171612 
                 SLC25A33 
                 0.0442 
                 −0.0663 
                 21.2 
                 1 
               
               
                 ENSG00000136504 
                 KAT7 
                 0.0442 
                 −0.0633 
                 18.3 
                 1 
               
               
                 ENSG00000176945 
                 MUC20 
                 0.0429 
                 −0.0644 
                 18.8 
                 1 
               
               
                 ENSG00000198018 
                 ENTPD7 
                 −0.0428 
                 0.0642 
                 20.4 
                 1 
               
               
                 ENSG00000111711 
                 GOLT1B 
                 −0.0415 
                 0.0623 
                 21.9 
                 1 
               
               
                 ENSG00000148840 
                 PPRC1 
                 −0.0366 
                 0.0549 
                 26.8 
                 1 
               
               
                 ENSG00000205730 
                 ITPRIPL2 
                 −0.0359 
                 0.0539 
                 26.6 
                 1 
               
               
                 ENSG00000149289 
                 ZC3H12C 
                 −0.0352 
                 0.0529 
                 32.7 
                 0.9 
               
               
                 ENSG00000168374 
                 ARF4 
                 −0.0344 
                 0.0516 
                 28.9 
                 1 
               
               
                 ENSG00000196739 
                 COL27A1 
                 −0.0335 
                 0.0502 
                 30.2 
                 1 
               
               
                 ENSG00000267041 
                 ZNF850 
                 0.0285 
                 −0.0428 
                 34.2 
                 1 
               
               
                 ENSG00000167397 
                 VKORC1 
                 −0.0276 
                 0.0415 
                 34.6 
                 1 
               
               
                 ENSG00000100461 
                 RBM23 
                 0.0257 
                 −0.0386 
                 38.6 
                 0.9 
               
               
                 ENSG00000042493 
                 CAPG 
                 −0.0236 
                 0.0354 
                 44.3 
                 1 
               
               
                 ENSG00000198113 
                 TOR4A 
                 −0.0224 
                 0.0335 
                 44.6 
                 0.9 
               
               
                 ENSG00000123427 
                 METTL21B 
                 −0.0222 
                 0.0333 
                 44.1 
                 1 
               
               
                 ENSG00000188917 
                 TRMT2B 
                 0.0218 
                 −0.0327 
                 44.2 
                 0.9 
               
               
                 ENSG00000072840 
                 EVC 
                 −0.0205 
                 0.0308 
                 47.4 
                 0.9 
               
               
                 ENSG00000147364 
                 ZBTB14 
                 0.0204 
                 −0.0306 
                 48.5 
                 0.9 
               
               
                 ENSG00000113068 
                 PFDN1 
                 −0.0199 
                 0.0299 
                 49.3 
                 0.9 
               
               
                 ENSG00000147364 
                 FBXO25 
                 0.0194 
                 −0.0291 
                 57.6 
                 0.9 
               
               
                 ENSG00000086062 
                 B4GALT1 
                 −0.0191 
                 0.0286 
                 51.7 
                 0.9 
               
               
                 ENSG00000148335 
                 NTMT1 
                 −0.019 
                 0.0284 
                 51.4 
                 0.9 
               
               
                 ENSG00000166262 
                 FAM227B 
                 0.0187 
                 −0.028 
                 49.4 
                 0.9 
               
               
                 ENSG00000177674 
                 AGTRAP 
                 −0.0186 
                 0.0278 
                 48.3 
                 0.9 
               
               
                 ENSG00000126458 
                 RRAS 
                 −0.0172 
                 0.0258 
                 51.2 
                 0.9 
               
               
                 ENSG00000128578 
                 STRIP2 
                 −0.0166 
                 0.0248 
                 52.7 
                 0.8 
               
               
                 ENSG00000126107 
                 HECTD3 
                 −0.0155 
                 0.0232 
                 55.8 
                 1 
               
               
                 ENSG00000198478 
                 SH3BGRL2 
                 0.0152 
                 −0.0229 
                 58.7 
                 0.8 
               
               
                 ENSG00000145685 
                 LHFPL2 
                 −0.0147 
                 0.022 
                 66.4 
                 0.8 
               
               
                 ENSG00000147548 
                 WHSC1L1 
                 0.0142 
                 −0.0212 
                 55.8 
                 0.8 
               
               
                 ENSG00000164465 
                 DCBLD1 
                 −0.0139 
                 0.0208 
                 56.8 
                 0.9 
               
               
                 ENSG00000166068 
                 SPRED1 
                 −0.0132 
                 0.0198 
                 59.3 
                 0.7 
               
               
                 ENSG00000233436 
                 BTBD18 
                 0.0121 
                 −0.0181 
                 67 
                 0.7 
               
               
                 ENSG00000068438 
                 FTSJ1 
                 −0.0116 
                 0.0174 
                 69.9 
                 0.7 
               
               
                 ENSG00000148834 
                 GSTO1 
                 −0.0115 
                 0.0173 
                 63.3 
                 0.7 
               
               
                 ENSG00000167106 
                 FAM102A 
                 0.0105 
                 −0.0157 
                 68.9 
                 0.9 
               
               
                 ENSG00000099904 
                 ZDHHC8 
                 −0.0102 
                 0.0154 
                 66.3 
                 0.7 
               
               
                 ENSG00000100311 
                 PDGFB 
                 −0.0097 
                 0.0146 
                 67.2 
                 0.8 
               
               
                 ENSG00000154079 
                 SDHAF4 
                 0.0095 
                 −0.0142 
                 79.3 
                 0.8 
               
               
                 ENSG00000090097 
                 PCBP4 
                 −0.0093 
                 0.0139 
                 70.2 
                 0.6 
               
               
                 ENSG00000196639 
                 HRH1 
                 −0.0092 
                 0.0139 
                 73.3 
                 0.7 
               
               
                 ENSG00000164898 
                 FMC1 
                 0.009 
                 −0.0136 
                 79.7 
                 0.8 
               
               
                 ENSG00000136068 
                 FLNB 
                 −0.0084 
                 0.0126 
                 70.1 
                 0.8 
               
               
                 ENSG00000129197 
                 RPAIN 
                 0.0083 
                 −0.0124 
                 72.3 
                 0.6 
               
               
                 ENSG00000127364 
                 TAS2R4 
                 0.008 
                 −0.012 
                 70.4 
                 0.6 
               
               
                 ENSG00000108423 
                 TUBD1 
                 0.0077 
                 −0.0116 
                 73.6 
                 0.6 
               
               
                 ENSG00000106080 
                 FKBP14 
                 −0.0075 
                 0.0112 
                 70.8 
                 0.6 
               
               
                 ENSG00000144401 
                 METTL21A 
                 −0.0067 
                 −0.01 
                 82.3 
                 0.7 
               
               
                 ENSG00000170921 
                 TANC2 
                 −0.0055 
                 0.0082 
                 82.9 
                 0.6 
               
               
                 ENSG00000070501 
                 POLB 
                 0.005 
                 −0.0075 
                 79.8 
                 0.8 
               
               
                 ENSG00000206579 
                 XKR4 
                 0.0043 
                 −0.0065 
                 76.9 
                 0.7 
               
               
                 ENSG00000157429 
                 ZNF19 
                 0.0042 
                 −0.0062 
                 77.4 
                 0.6 
               
               
                 ENSG00000255346 
                 NOX5 
                 −0.0041 
                 0.0061 
                 90.7 
                 0.7 
               
               
                 ENSG00000105856 
                 HBP1 
                 0.0038 
                 −0.0057 
                 86.6 
                 0.6 
               
               
                 ENSG00000143443 
                 C1orf56 
                 0.0038 
                 −0.0057 
                 78.7 
                 0.6 
               
               
                 ENSG00000157551 
                 KCNJ15 
                 −0.0037 
                 0.0055 
                 95.1 
                 0.6 
               
               
                 ENSG00000293590 
                 N0OR1 
                 −0.0027 
                 0.004 
                 86.4 
                 0.6 
               
               
                 ENSG00000164402 
                 43351 
                 −0.001 
                 0.0016 
                 90.5 
                 0.5 
               
               
                 ENSG00000087495 
                 PHACTR3 
                 0.001 
                 −0.0015 
                 87.7 
                 0.4 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 Reference Sequences for normalization. 
               
            
           
           
               
               
               
            
               
                 SEQ 
                   
                   
               
               
                 ID 
                   
                   
               
               
                 NO: 
                 Name 
                 Target Sequence (5′-3′) 
               
               
                   
               
            
           
           
               
               
               
            
               
                 1 
                 ACE 
                 GAAGTACGGCACCCAGGCCAGGAAGTTTGATGTGAACCAGTTGCAGAACACCAC 
               
               
                   
                   
                 TATCAAGCGGATCATAAAGAAGGTTCAGGACCTAGAACGGGCAGCA 
               
               
                   
               
               
                 2 
                 ACIN1 
                 CCTGCAGAGCATGAAGTAAAGAAAGTGACTTTAGGAGATACCTTAACTCGACGT 
               
               
                   
                   
                 TCCATTAGCCAGCAGAAGTCCGGAGTTTCCATTACCATTGATGACC 
               
               
                   
               
               
                 3 
                 ACOT9 
                 AAATTTGCCACCCTCAGGAGCGGAACATTTTCAATCGGATCTTTGGTGGTTTCC 
               
               
                   
                   
                 TTATGAGGAAGGCATATGAACTTGCGTGGGCTACTGCTTGTAGCTT 
               
               
                   
               
               
                 4 
                 AGTRAP 
                 TGGCTCAGCGGGACTCCATCGACGCCATAAGCATGTTTCTGGGTGGCTTGCTGG 
               
               
                   
                   
                 CCACCATCTTCCTGGACATCGTGCACATCAGCATCTTCTACCCGCG 
               
               
                   
               
               
                 5 
                 ANAPC5 
                 GGTTACAGTACTTGGCCTCTGAAACAGTGCTGAACTTGGCTTTTGCGCAGCTCA 
               
               
                   
                   
                 TTCTTGGAATCCCAGAACAGGCCTTAAGTCTTCTCCACATGGCCAT 
               
               
                   
               
               
                 6 
                 APBB2 
                 AAATTCCTTACGCAGTGGTATTCATGATGGTGCCCTATCTAAGTCCAGGACTGT 
               
               
                   
                   
                 TTTCCTACAGCGTGCCTCAAAAGTGTTGTAGAGGGCAGGATTCTAC 
               
               
                   
               
               
                 7 
                 ARF4 
                 GTCTCTTCGTAACAGAACATGGTATGTTCAAGCCACTTGTGCAACACAAGGAAC 
               
               
                   
                   
                 TGGTCTGTATGAAGGACTTGACTGGCTGTCAAATGAGCTTTCAAAA 
               
               
                   
               
               
                 8 
                 ATF2 
                 GTGGGAGCCCGTGGCCTTTAAAGTGCCGTTCAGCCTTTTCCTCCAGGGGTGCTT 
               
               
                   
                   
                 TGTAAACACGGCTGTGCTCAGGGCTCGCGGGTGACCGAAAGGATCA 
               
               
                   
               
               
                 9 
                 ATXN2L 
                 TTCAATGAGGAGAACTACGGTGTGAAGACTACCTATGATAGCAGTCTTTCTTCT 
               
               
                   
                   
                 TATACGGTGCCCTTAGAAAAGGACAACTCAGAAGAGTTTCGTCAGC 
               
               
                   
               
               
                 10 
                 B4GALT1 
                 ACACAAAGGAGACAATGCTCTCTGATGGTTTGAACTCACTCACCTACCAGGTGC 
               
               
                   
                   
                 TGGATGTACAGAGATACCCATTGTATACCCAAATCACAGTGGACAT 
               
               
                   
               
               
                 11 
                 BTBD18 
                 CTTGAAGATTATACCTGTGGAGCTGGGATGTGGTGCTCAGGAAGAATATAAGTA 
               
               
                   
                   
                 GTCAGCATTGTAGCAGTTGAGTCTCAGTGGTAATGGAAATGAGGAA 
               
               
                   
               
               
                 12 
                 C10orf55 
                 TTATTGCTTTCGGCAGTAAGGGGGTTTGTTTGATGGTGCTATCAGAGGGGGAAA 
               
               
                   
                   
                 GGCAAGGCCAGATTACTGAAAATTTGCAGCTTGGTTTAAAGTCCGT 
               
               
                   
               
               
                 13 
                 C10orf56 
                 GCTTTTTGGAAACGGGTCAGGATTGGCCTGGAGGATATTTGGAATAGCCTCTCT 
               
               
                   
                   
                 TCAGTGTTCACAGAGATGCAACCAATAGACAGAAACCAGAGGTAAT 
               
               
                   
               
               
                 14 
                 C1QTNF6 
                 CCCTGCACAGCGGCGAGGACTTCCAGACGCTGCTCTTCGAAAGGGTCTTTGTGA 
               
               
                   
                   
                 ACCTTGATGGGTGCTTTGACATGGCGACCGGCCAGTTTGCTGCTCC 
               
               
                   
               
               
                 15 
                 CAPG 
                 TGACTCCAGCCCATTTGCCCTTGAACTGCTGATATCTGATGACTGCTTTGTGCT 
               
               
                   
                   
                 GGACAACGGGCTCTGTGGCAAGATCTATATCTGGAAGGGGCGAAAA 
               
               
                   
               
               
                 16 
                 CARD19 
                 CCTGGTGCAGGACACGCCTTTCCTGACAGGCCATGGGCGCTTGAGTGAGCAGCA 
               
               
                   
                   
                 GGTGGACAGGATCATCCTCCAGCTGAACCGTTACTACCCACAGATC 
               
               
                   
               
               
                 17 
                 COL27A1 
                 CACCGCCCAGCACCCGGCCCCTACCTCCTACCACCAGCTCCTCTAAAAAACCCA 
               
               
                   
                   
                 TTCCCACACTAGCTCGGACTGAGGCCAAGATAACCAGCCATGCCAG 
               
               
                   
               
               
                 18 
                 DCBLD1 
                 CTCTTGTTGAACACAAGTGAAGTAACCGTCCGCTTTGAGAGTGGATCCCACATT 
               
               
                   
                   
                 TCTGGCCGGGGTTTTTTGCTGACCTATGCGAGCAGCGACCATCCAG 
               
               
                   
               
               
                 19 
                 DCTN4 
                 CTTCCAGCCAGTCTGTGCTTCACAGCTCTATCCTCGCCACAAACATCTTCTGAT 
               
               
                   
                   
                 CAAACGGTCCCTGCGCTGCCGTAAATGTGAACATAATTTGAGCAAG 
               
               
                   
               
               
                 20 
                 METTL21B 
                 CTGTTCTCAGAGAAGGAGGATGGTAAGGTATCCAGGATTTTTAGGGGGTAAGGG 
               
               
                   
                   
                 AGATATATGGGATGTGAGAGCAGTGATTGTAGACAGACTGTCACTG 
               
               
                   
               
               
                 21 
                 ENTPD7 
                 GGGAGCCATTCTATATAAAACACGATTCTTACCACTCAGGGATCTTCGGCAGGA 
               
               
                   
                   
                 AGGTGTCCGACAAGCCCATGGTAGCTGGTTCCGTCTCTCCTTTGTA 
               
               
                   
               
               
                 22 
                 EVC 
                 TTTCTTGTGGACCAGTTTAAGTGTTCCAGCTCCAAAGCCCGACAGCTGATGATG 
               
               
                   
                   
                 ACTCTGACGGAAAGAATGATTGCAGCCGAAGGGCTATTGTGCGATT 
               
               
                   
               
               
                 23 
                 EWSR1 
                 GAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAA 
               
               
                   
                   
                 CCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCAC 
               
               
                   
               
               
                 24 
                 FAM102A 
                 CTGGAGAAGAGTCCTGCTTTCTCTGGAGTCCAGACCTGTATCATTCCATGAGGA 
               
               
                   
                   
                 ACTTTCCCCTTCAGATCACCTCTGCGCCACATCTCATCCATGCCTC 
               
               
                   
               
               
                 25 
                 FAM153B 
                 CAGGGGTCCTTCAGCCTCTGTGGGGGCCTGGGGTGGCCTCATGGCCCCATTTTT 
               
               
                   
                   
                 CAAGATGAGGTTGGAGGCTTCTGTATGTAGAGGGCACTGGCTTGGG 
               
               
                   
               
               
                 26 
                 FAM227B 
                 CCGCCTCAAGCCTCGCAGCCTTTCACCCAGTTTCCTCCCGATTCTTGCTGGGAC 
               
               
                   
                   
                 AACAAAATTGGGAAGCGGTTCTCGAAACATACTGTCAAGGCGTAGT 
               
               
                   
               
               
                 27 
                 FBXO25 
                 TCTTCAGATGACTAAGCAAGTGAACAATGGCCTCACCCTCAGTGACCTTCCTCT 
               
               
                   
                   
                 GCACATGCTGAACAACATCCTATACCGGTTCTCAGACGGATGGGAC 
               
               
                   
               
               
                 28 
                 FKBP14 
                 TTATGTGTAACTGGCTCTGAGTCTCTGCTTGAGGACCAGAGGAAAATGGTTGTT 
               
               
                   
                   
                 GGACCTGACTTGTTAATGGCTACTGCTTTACTAAGGAGATGTGCAA 
               
               
                   
               
               
                 29 
                 FLNB 
                 GGTTTGGAGAAATCTGGATGCATTGTCAACAACCTGGCCGAGTTCACTGTGGAT 
               
               
                   
                   
                 CCTAAGGATGCTGGAAAAGCTCCCTTAAAGATATTTGCTCAGGATG 
               
               
                   
               
               
                 30 
                 FMC1 
                 GAGTCTGCTGGCTTGGTGGGTCTCAAGTTGCCCCATCAGCCTGGAGGGAAGGGC 
               
               
                   
                   
                 TGGGAGCCATGAACATGGAGAATATCCTTGGATGCTGCATTCATAG 
               
               
                   
               
               
                 31 
                 FTSJ1 
                 GATGACGGGGCTCACGTTGTACGTTCACATCAGGTCCCGGCCCGCCGGAACCTG 
               
               
                   
                   
                 GGCGATCCACGATGCCGAGTTTGCCACGCTGCGACAGCCCATAGGC 
               
               
                   
               
               
                 32 
                 GOLT1B 
                 TCCGGAAGACGTGGCGGCTCTCGCCTGGGCTGTTTCCCGGCTTCATTTCTCCCG 
               
               
                   
                   
                 ACTCAGCTTCCCACCCTGGGCTTTCCGAGGTGCTGTCGCCGCTGTC 
               
               
                   
               
               
                 33 
                 GSTO1 
                 TCTGACTAATAAGAAGACGACCTTCTTTGGTGGCAATTCTATCTCTATGATTGA 
               
               
                   
                   
                 TTACCTCATCTGGCCCTGGTTTGAACGGCTGGAAGCAATGAAGTTA 
               
               
                   
               
               
                 34 
                 HBP1 
                 CTTGTGGAGGACCTGGTGGTCAAGACTTTGCAAGATCTGGATTCAGTAAAAACT 
               
               
                   
                   
                 GTGGCTCACCTGGATCATCACAGCTCTCTTCCAATTCTTTGTATGC 
               
               
                   
               
               
                 35 
                 HECTD3 
                 CCGTCCACCTCCCGATCATCGAGATCCGCATCGTGGAGTGCCGAGATGATGGGA 
               
               
                   
                   
                 TTGATGTTCGTCTCCGAGGGGTCAAGATCAAGTCATCTAGACAGCG 
               
               
                   
               
               
                 36 
                 HRH1 
                 GTGGCAGCTCAAAATGATATGTTTGAGTAGACGAACAGCTGACATGGAGTTCCC 
               
               
                   
                   
                 GTGCACCTACGGAAGGGGACGCTTTGAAGGAACCAAGTGCATTTTT 
               
               
                   
               
               
                 37 
                 ITPRIPL2 
                 TTCTGACTCAGCAGCTCCACCAAAATTGACATCCTAGCAAACACTGTGAAGGAA 
               
               
                   
                   
                 TTAACCTAAGTGCTTCCAGAGCATCTCATGTAACCTCTATGGAGTA 
               
               
                   
               
               
                 38 
                 KAT7 
                 TCCAGTTACTCCTTATATGTGTGTTCTATGGAGGGGCAGGGAAAAGGTGGCACT 
               
               
                   
                   
                 TGTGAGTGTGTGTGGATTGGCAGGGGGTCCATTCACTTTGGGTTCC 
               
               
                   
               
               
                 39 
                 KCNJ15 
                 AGACCCGCCACATCAGCACCATCCGAGAGCTTATTAGTAATGTGTAGATTCTCA 
               
               
                   
                   
                 TGTCCCAGCCAGACTTACAGAATTGGGGTCTGTATCTTAACAAGAA 
               
               
                   
               
               
                 40 
                 KIAA0100 
                 ATGGTTCTCAAGGTGGATACCTCTGAGTCCTTATGGCATATTCAGATCAGTAGA 
               
               
                   
                   
                 AGCAGATTTCTTTTGGATAGTGATGGGAAAAGGCTAATCTGTGAGG 
               
               
                   
               
               
                 41 
                 LHFPL2 
                 TGATTAACTCCGTGGACTCCTGACTCTTTCTTCGCCCGGAACATCAATATGTGT 
               
               
                   
                   
                 CATGTCATTGTCACCTGTCGCTCGATGCTCTGGACCTTGCTGAGTA 
               
               
                   
               
               
                 42 
                 METTL21A 
                 TCGTGCCCTATGAGGAGACCACGGAATTTGGGTTGCAGAAATTCCACAAGCCTC 
               
               
                   
                   
                 TTGCAACTTTTTCCTTTGCAAACCACACGATCCAGATCCGGCAGGA 
               
               
                   
               
               
                 43 
                 MGA 
                 TCCAAGTGGAATGAACTTATTCAGGCACCCTAATGGGCAGATTGTCCAGCTTCT 
               
               
                   
                   
                 ACCTTTGCATCAGCTTCGAGGCTCTAATACCCAGCCCAACTTACAG 
               
               
                   
               
               
                 44 
                 MUC20 
                 TTGAGACACCAAGTTACGTCAAAGTCTCAGGAGCAGCTCCGGTCTCCATAGAGG 
               
               
                   
                   
                 CTGGGTCAGCAGTGGGCAAAACAACTTCCTTTGCTGGGAGCTCTGC 
               
               
                   
               
               
                 45 
                 NCOR1 
                 TAGGAGTGAGCATGAGATTTCTGAAATTATTGATGGGCTCTCTGAGCAGGAGAA 
               
               
                   
                   
                 TAATGAGAAACAAATGCGGCAGCTCTCTGTGATTCCACCTATGATG 
               
               
                   
               
               
                 46 
                 NDOR1 
                 ACCTGCCCTCCACTGCCCTCTGTCAGATGGACTTTGCCGTCCTGGGCCTCGGGG 
               
               
                   
                   
                 ACTCCTCATACGCCAAGTTCAACTTCGTGGCCAAGAAGCTGCACCG 
               
               
                   
               
               
                 47 
                 NOX5 
                 AGCTCCATAAGGTGGACTTTATCTGGATCAACAGAGACCAGCGGTCTTTCGAGT 
               
               
                   
                   
                 GGTTTGTGAGCCTGCTGACTAAACTGGAGATGGACCAGGCCGAGGA 
               
               
                   
               
               
                 48 
                 WHSC1L1 
                 GAAAGGGAAAGTTAAGGATGCTGGAGCAGAACAATGGATTTCTCTTTCTCTTTC 
               
               
                   
                   
                 ATGCAAGGGATCATGGGAAACACAATTCAGCAACCACCTCAACTCA 
               
               
                   
               
               
                 49 
                 NTMT1 
                 AGGATCACCAAGCGGCTGCTCCTGCCGCTGTTCAGAGAGGTGGATATGGTCGAC 
               
               
                   
                   
                 ATAACGGAGGACTTCCTGGTTCAAGCCAAGACCTACCTGGGGGAGG 
               
               
                   
               
               
                 50 
                 OLR1 
                 CCCAGGTGTCTGACCTCCTAACACAAGAGCAAGCAAACCTAACTCACCAGAAAA 
               
               
                   
                   
                 AGAAACTGGAGGGACAGATCTCAGCCCGGCAACAAGCAGAAGAAGC 
               
               
                   
               
               
                 51 
                 PAPPA 
                 CAATGCGACGACATGAATAAGATCAATGGTGATGGCTGCTCCCTTTTCTGCCGA 
               
               
                   
                   
                 CAAGAAGTCTCCTTCAATTGTATTGATGAACCCAGCCGGTGCTATT 
               
               
                   
               
               
                 52 
                 PCBP4 
                 CATCACCGGGTCTACAGCAGCTGTCTTCCATGCAGTCTCCATGATTGCTTTCAA 
               
               
                   
                   
                 ACTGGATGAGGACCTTTGTGCTGCTCCTGCAAATGGTGGAAATGTC 
               
               
                   
               
               
                 53 
                 PDGFB 
                 GATTCACCTCTTCCTCTGGTTCCTTTCATCTCTCTACCTCCACCCTGCATTTTC 
               
               
                   
                   
                 CTCTTGTCCTGGCCCTTCAGTCTGCTCCACCAAGGGGCTCTTGAAC 
               
               
                   
               
               
                 54 
                 PDGFC 
                 GCAACTTATGAAAGTAGACATTCAGATCCAGCCATTACTAACCTATTCCTTTTT 
               
               
                   
                   
                 TGGGGAAATCTGAGCCTAGCTCAGAAAAACATAAAGCACCTTGAAA 
               
               
                   
               
               
                 55 
                 PFDN1 
                 TGAGAGAGGCAGTGGCCGTCTCCACCTCAGCTCCTGCTCCCTCTGCATCAGAGC 
               
               
                   
                   
                 CCTTCCTTTCTTGGGGGATGGGCCTTGCCCTCTTCTCTTTTCCCTT 
               
               
                   
               
               
                 56 
                 PHACTR3 
                 GGAGAACAAGGAGAACCTGATCATAAATTCTGAACTCAAAGACGACTTGCTTTT 
               
               
                   
                   
                 GTATCAGGACGAGGAGGCGCTGAACGACTCCATTATTTCTGGAACA 
               
               
                   
               
               
                 57 
                 POLB 
                 TCTGAATACATTGCTACAGTCTGTGGCAGTTTCAGAAGAGGTGCAGAGTCCAGT 
               
               
                   
                   
                 GGTGACATGGATGTTCTCCTGACCCATCCCAGCTTCACTTCAGAAT 
               
               
                   
               
               
                 58 
                 PPRC1 
                 AGAGAAGTGCTGGACAAAGTAGTCCTGCTAAAGAAGGCCCTCTAGACCTCTACC 
               
               
                   
                   
                 CAAAGCTGGCTGACACTATCCAAACCAATCCTATACCAACCCATCT 
               
               
                   
               
               
                 59 
                 RAB5B 
                 TGTGGATCTCCATGAACAGTCCCAGCAGAACAAGAGCCAGTGTTGTAGCAACTG 
               
               
                   
                   
                 AGGGGGTGGCTAGCAGCAAACAAGTATGGAGCTAGCACAAGAGCTA 
               
               
                   
               
               
                 60 
                 RBM23 
                 TCAATATCACTGAAGACATGCTCCGGGGCATCTTTGAGCCCTTTGGTAAAATTG 
               
               
                   
                   
                 ATAATATTGTCCTGATGAAGGACTCAGATACAGGCCGCTCTAAAGG 
               
               
                   
               
               
                 61 
                 RPAIN 
                 CTGAGACTTGTGTATCTAATTGCCTATTGGACACCTCCATCTGGGTAAACCCAG 
               
               
                   
                   
                 GCATCCAGAACTTTCCCTCAAGACTTACCTCCCTCAGTGCAGGTCG 
               
               
                   
               
               
                 62 
                 RRAS 
                 CAGTACATGCGTGCTGGCCACGGCTTCCTGCTGGTGTTCGCCATTAACGACCGG 
               
               
                   
                   
                 CAGAGTTTCAACGAGGTGGGCAAGCTCTTCACGCAGATTCTGCGGG 
               
               
                   
               
               
                 63 
                 SDHAF4 
                 AGTCTGAACTTGTCAAACAGTCCCTTAAGAAGCCGAAGTTACCAGAAGGTCGTT 
               
               
                   
                   
                 TTGATGCACCAGAGGATTCCCATTTAGAGAAAGAACCACTGGAAAA 
               
               
                   
               
               
                 64 
                 8-Sep 
                 TCGATGCGCAGTTTGAAAATTATCTGCAGGAGGAGCTGAAGATCCGCCGCTCGC 
               
               
                   
                   
                 TCTTCGACTACCATGACACAAGGATCCACGTTTGCCTCTACTTCAT 
               
               
                   
               
               
                 65 
                 SH3BGRL2 
                 CAGGTGTACTTTCTTAATGACTGAAAGATAAGTGGGTAGCACCGTCAGAGAGAA 
               
               
                   
                   
                 AATGTTGGATCTGCCCTAGGTTATAGTAGATGCCGGAATTGCGTAA 
               
               
                   
               
               
                 66 
                 SLC25A33 
                 CGCCTGGTGTTCCGGGAAGAAGGCTACCTTGCCTTTTATAGAGGACTGTTTGCC 
               
               
                   
                   
                 CAGCTTATCCGGCAGATCCCAAATACTGCCATTGTGTTGTCTACTT 
               
               
                   
               
               
                 67 
                 SPDYE3 
                 AACAAAAGATCTTCTACTTCCTGTACGGGAAGACCCACTCTCACATACCCTTGC 
               
               
                   
                   
                 GCCCTAAGCATTGGTTCCAGTTATGCCGTCCCATGAACCCGAGGGC 
               
               
                   
               
               
                 68 
                 SPEN 
                 CTATCCAGCTCGAGGGAGAGAGTTTTATTCAGAATGGGAAACTTACCAAGGAGA 
               
               
                   
                   
                 CTACTATGAATCACGATACTACGATGATCCTCGGGAATACAGGGAT 
               
               
                   
               
               
                 69 
                 SPRED1 
                 TTCAGAGCAGAAGTATGGAATACGTACAGCGGCAAATATCCAAGGAATGTGGAA 
               
               
                   
                   
                 GCCTAAAGTCCCAAAATAGGGTCCCTTTGAAATCAATCAGACATGT 
               
               
                   
               
               
                 70 
                 SRRM1 
                 CCCGACCACGATCTCGGTCACGCTCCAAATCAAGATCCCGGACGCGGTCCCGCT 
               
               
                   
                   
                 CTCCTTCTCACACTCGACCTAGACGGCGCCATAGATCCCGATCAAG 
               
               
                   
               
               
                 71 
                 STRIP2 
                 AGCCGAGTTGTCAGAATTGTATAGTTACACTGAGAACCTGGAATTCACCAATAA 
               
               
                   
                   
                 CAGGAGGTGCTTTGAAGAAGATTTCAAGACTCAAGTGCAGGGCAAG 
               
               
                   
               
               
                 72 
                 TANC2 
                 AGGGTTTGAGTAAAAAAGTTGGTGTATCATCCTCCATCCTCCAAGGTCTCTGGA 
               
               
                   
                   
                 TCTCTTATAGCACAGAAGGTCTTTCCATGGCACTGGCGTCTTTACG 
               
               
                   
               
               
                 73 
                 TAS2R4 
                 GGACTCGAGCAGTGTCTGGTTTGTGACCTTGCTCAATATCTTGTACTGTGTGAA 
               
               
                   
                   
                 GATTACTAACTTCCAACACTCAGTGTTTCTCCTGCTGAAGCGGAAT 
               
               
                   
               
               
                 74 
                 TGFBR1 
                 GAATCCTTCAAACGTGCTGACATCTATGCAATGGGCTTAGTATTCTGGGAAATT 
               
               
                   
                   
                 GCTCGACGATGTTCCATTGGTGGAATTCATGAAGATTACCAACTGC 
               
               
                   
               
               
                 75 
                 TOR4A 
                 TCTGGTCTGGCCTTCGTGTTGGCTTCAAGGTGGTAACAGAGAGAGCTGCAGAGT 
               
               
                   
                   
                 GGGGGTGTGTTTGCCAGTCCCTGCATGGGTGAATGTTGGGGTGCCC 
               
               
                   
               
               
                 76 
                 TRIP12 
                 ATGTCCAACCGGCCTAATAACAATCCAGGGGGGTCACTGCGACGTTCACAGAGG 
               
               
                   
                   
                 AACACTGCCGGGGCCCAACCACAAGACGACTCAATAGGAGGAAGAA 
               
               
                   
               
               
                 77 
                 TRMT2B 
                 AGTACCATGACCCGTTGCAGCCATCAGCAGTCTCCCTATCAGCTTCTGTTTGGG 
               
               
                   
                   
                 GAACCCTACATCTTTGAAGAACTTCTGAGCTTGAAGATCCGCATCT 
               
               
                   
               
               
                 78 
                 TUBD1 
                 GCCATCCATAAGATCTGTGCAAAACTGATGAATATCAAGCAGATCTCCTTTAGT 
               
               
                   
                   
                 GATATCAATCAAGTCCTCGCACATCAGCTGGGAAGTGTGTTCCAGC 
               
               
                   
               
               
                 79 
                 VKORC1 
                 AAGAGGCACTGAGCCCTCAACCCAAGCCAGGCTGACCTCATCTGCTTTGCTTTG 
               
               
                   
                   
                 GCATGTGAGCCTTGCCTAAGGGGGCATATCTGGGTCCCTAGAAGGC 
               
               
                   
               
               
                 80 
                 WDR26 
                 GGAGGCACTTCAAGTTCTACGCTGTGAATTGACGCCGCTGAAATACAATACAGA 
               
               
                   
                   
                 GCGCATTCATGTTCTTAGTGGGTATCTGATGTGTAGCCATGCAGAA 
               
               
                   
               
               
                 81 
                 XKR4 
                 CCACATCTTGCAGCTCGGGCAAATCTGGAGATATTTCCACACAATATACTTAGG 
               
               
                   
                   
                 TATTCGAAGCCGACAGAGTGGGGAGAATGACAGATGGAGGTTTTAC 
               
               
                   
               
               
                 82 
                 ZBTB14 
                 GTTTGAGTATTTGCTTTATGGTCACCATCGGGAGCAGATTGCCTGCCAGGCGTG 
               
               
                   
                   
                 TGGGAAGACGTTTTCTGATGAAGGCAGATTGAGGAAGCATGAGAAA 
               
               
                   
               
               
                 83 
                 ZC3H12C 
                 CAAATCTGAGTCTCTCAGGCCCACGAAGCCCTGAAAGGCGTTTCTCCTTAGACA 
               
               
                   
                   
                 CAGATTATAGAATAAGTTCCGTAGCTTCTGACTGCAGCAGTGAAGG 
               
               
                   
               
               
                 84 
                 ZDHHC8 
                 ACCACTGCCCCTGGGTCAACAACTGCATCGGGCGTCGAAACTATCGCTACTTCT 
               
               
                   
                   
                 TCCTGTTCCTGCTGTCACTCAGTGCACACATGGTGGGCGTCGTGGC 
               
               
                   
               
               
                 85 
                 ZNF19 
                 GGGAAAGTCTTTAGTTATAGTCATGGCAGCTCCTCAACCCCATGATTGTGATGA 
               
               
                   
                   
                 GATTGGGAAGCCCACTGTAACACTGGAGAGCCCAGGTTATATCAGA 
               
               
                   
               
               
                 86 
                 ZNF207 
                 AAGCCTACATTCCCTGCTTATACACAGTCTACAGCTTCAACAACTAGTACAACA 
               
               
                   
                   
                 AATAGTACTGCAGCTAAACCAGCGGCTTCAATAACAAGTAAGCCTG 
               
               
                   
               
               
                 87 
                 ZNF850 
                 GGTGAATAAATGGAGCCAATAGACTTGTTCACTGCATGGTTACGTCAGAGGCGT 
               
               
                   
                   
                 GTAAACCAGAGCAACTTCTTCTTGAATAGGAGCTGTGTAAAGTAAC 
               
               
                   
               
            
           
         
       
     
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         29. Weigelt B, Glas A M, Wessels L F, Witteveen A T, Peterse J L, van&#39;t Veer L J. Gene expression profiles of primary breast tumors maintained in distant metastases. Proceedings of the National Academy of Sciences of the United States of America 2003; 100(26):15901-5 doi 10.1073/pnas.2634067100. 
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