Patent Publication Number: US-2022226310-A1

Title: Bio-Based Medicines and Methods of Increasing Patient Compliance

Description:
RELATED APPLICATIONS 
     This application claims the priority benefit of U.S. Provisional Patent Application Ser. No. 62/677,161, filed 28 May 2018. 
    
    
     BACKGROUND 
     To be optimally effective, most medications require scheduled use over a period of time. Whether people follow this regimen is termed “compliance” or, equivalently, “adherence,” and the failure of people to comply or adhere to the regimen is known to be a significant problem. Speaking generally of patients, and with reference to three earlier publications, McElnay et al. in “Self-reported medication non-compliance in the elderly,” Eur. J. Clin Pharmacol (1997) 53: 171-178 state “It is now widely accepted that, in general terms, one third of patients comply ‘partially,’ taking between 40% and 80% of doses; one third comply ‘satisfactorily’, occasionally taking more, occasionally taking less of the prescribed amount; one sixth take less than 40% of the prescribed doses with widely varying intervals; while one sixth are good compliers.” 
     In view of this problem, there is a strong incentive to provide new solutions to improve patient compliance. 
     SUMMARY 
     Pharmaceutically active compounds are disclosed that are based on known structures wherein the structures are fully or partially derived from biomass such that the  14 C content in the structure or selected moiety is similar to the  14 C content in living organisms, on the order of 1 part per trillion. Also disclosed are methods of treating a patient comprising a step of administering (or prescribing) one or more of the above-described bio-based pharmaceutical compounds or compositions to a patient. Preferably, the patient is aware of the bio-based nature of the drug composition. The disclosed compounds have a higher percentage of bio-based carbon (that is, a higher  14 C/ 12 C isotopic ratio) than is present in fossil-based compounds. 
     In one aspect, the invention provides a pharmaceutically active compound that is at least partially derived from biomass. The pharmaceutically active compound that is at least partially derived from biomass can be any of the compounds in Table 1; especially preferred examples include: Chlorhexidine (chlorhexamed forte), Ambroxol (mucosolvan), Cetirizine (Hexal), Bisacodyl (Ducolax), Xylomethazoline (Olynth), Diclofenac (used to treat pain and inflamatory diseases)(forte voltaren), Clotrimazole (canesten), Omeprazole (omep Hexal), Flurbiprofen (to treat pain and arthritis) (Dobendan), Naproxen (Dolormin), Doxilamine (Hoggar), Ioperamide, Ibuprofen, or lansoprazole. In some preferred embodiments, the pharmaceutically active compound has one or more of the following characteristics: comprising at least one aromatic group that is derived from biomass; where all the aromatic groups in the active compound are derived from biomass; where the entire compound is derived from biomass; the pharmaceutically active compound having a  14 C: 12 C isotopic ratio that is similar to the  14 C: 12 C isotopic ratio of a living organism (approximately 1 part per trillion); the compound can be pure or in a mixture such as with one or more pharmaceutically acceptable excipient and/or in a mixture comprising at least two pharmaceutically active compounds; the compound contains at least 10%, at least 40%, or at least 50%, or at least 70%, or 100%, or between 10 and 90%, or between 40 and 90%, or between 50 and 90 mass % bio-based carbon (percentages are always in mass unless indicated otherwise); the specific compounds listed above may be characterized by carbon ratios characteristic of the synthesis; the bio-based carbon in any of the foregoing percentages may be derived from plants (which may be termed raw plant materials or “environmentally-friendly renewable raw plant materials”); composition is in medicine delivery form such as tablet, syrup, IV bag, or capsule; the compound is in a composition that comprises at least 1 mg, or at least 5 mg, or at least 10 mg, or at least 40 mg of the active compound in a medicine delivery form; the composition comprises at least 1%, 2% or at least 10%, or at least 50%, or at least 80% by mass of the active compound; and/or wherein the compound or composition is characterizable by an increase in compliance of at least 10%, or at least 30%, or between 20 and 67%, or between 20 and 58%, or between 10 and 37%, or between 10 and 28%, or between 20 and 28%. 
     In an alternative aspect, the invention can be described as a substance X for use in improving patient compliance with a pharmaceutical dosing regime, wherein substance X is one of Chlorhexidine (chlorhexamed forte), Ambroxol (mucosolvan), Cetirizine (Hexal), Bisacodyl (Ducolax), Xylomethazoline (Olynth), Diclofenac (used to treat pain and inflamatory diseases)(forte voltaren), Clotrimazole (canesten), Omeprazole (omep Hexal), Flurbiprofen (to treat pain and arthritis) (Dobendan), Naproxen (Dolormin), Doxilamine (Hoggar), Ioperamide, and Ibuprofen; and wherein substance X comprises at least 10 mass % of bio-based carbon. Preferably, at least 40%, or at least 50%, or at least 70%, or 100% bio-based carbon. Likewise, this substance can additionally, have one or any combination of the characteristics described above or in the detailed description section below. In broader aspects, the substance can be any of the compounds in Table 1. 
     In another aspect, the invention provides a pharmaceutically active compound in which between 10 and 90 mass % of the carbon atoms are bio-based. The compound may be selected from Table 1. Compound is Chlorhexidine (chlohexamed forte), Ambroxol (mucosolvan), Cetirizine (Hexal), Bisacodyl (Ducolax), Xylomethazoline (Olynth), Diclofenac (forte voltaren), Clotrimazole (canesten), Omeprazole (omep Hexal), Flurbiprofen (Dobendan), Naproxen (Dolormin), Doxilamine (Hoggar), Ioperamide, or Ibuprofen. Preferably, at least 40%, or at least 50%, or at least 70%, of the carbons in the active compound is bio-based carbon. The compound can be used to study metabolism of drug as compared to a conventional non-bio-based drug by assessing metabolites, transport, and/or distribution of  14 C-containing compounds or moieties. 
     The invention also includes methods of treating a disease state comprising administering to patient in need thereof, a composition comprising a pharmaceutically active compound that is at least partially derived from biomass and, optionally, having one or any combination of the above characteristics. In preferred embodiments, the patient knows that the at least one pharmaceutically active compound is at least partially derived from biomass. Preferably, the compound is administered in a dosage regimen comprising multiple doses administered (in some preferred embodiments, self-administered) over a period of at least 3 days, or at least 5 days, or at least 10 days, or at least 30 days, in some embodiments between 3 and 30 days. The methods of treating the disease state preferably improve patient compliance as compared with conventionally-derived (i.e., derived from fossil fuels) pharmaceuticals. 
     In a related aspect, the invention provides a method of improving patient compliance with a pharmaceutical dosing regime, comprising administering a pharmaceutically active compound that is at least partially derived from biomass in the dosing regime. 
     In some aspects, the invention provides a pharmaceutically active compound that is at least partially derived from biomass for treating a disease state: Chlorhexidine for treating infections or for tracking metabolism, Ambroxol for treatment of respiratory diseases, Cetirizine for the treatment of allergy symptoms, Bisacodyl to treat constipation, Xylomethazoline to treat nasal congestion, Diclofenac to treat pain and inflamatory diseases, Clotrimazole to treat fungal infections, Omeprazole to treat stomach ulcers and acid reflux, Flurbiprofen to treat pain and arthritis, Naproxen to treat fever and pain, Doxilamine to treat allergy symptoms, Ioperamide to treat diarrhea, and Ibuprofen to treat fever and pain, lansoprazole for treating stomach ulcers, a damaged esophagus, gastroesophageal reflux disease (GERD), or high levels of stomach acid, or mephentermine for treatment of low blood pressure. 
     In another aspect, the pharmaceutically active compound is used to study metabolism of drug as compared to a conventional non-bio-based drug by assessing metabolites, transport, and/or distribution of  14 C-containing compounds or moieties. The invention provides a method of assessing the metabolism of a pharmaceutically active compound in a patient population, including the steps of (i) administering to patients in the patient population a pharmaceutically active compound that is at least partially derived from biomass and (ii) assessing the isotopic ratio of at least one metabolite of the pharmaceutically active compound. 
     In a further aspect, the invention provides a method of making a biomass-based pharmaceutically active compound comprising reacting a biomass-based aromatic with another organic molecule to yield an at least partially biomass based pharmaceutically active molecule. 
     The compounds, compositions, and methods disclosed herein provide certain advantages over the art, including increased patient acceptance of the drug product and patient compliance. It is a utility of the disclosed compounds, compositions, and methods, that with patient knowledge that the drug product or its constituent pharmaceutically active compound is sourced from natural feedstocks such as biomass, preferably plants, (including but not limited to, wood, corn stover, sugar cane bagasse, other agricultural resources), patient compliance improves. Due to increased patient confidence in bio-based cures, the disclosed compounds, compositions and methods lead to higher patient compliance (with better effectiveness and reduced recurrence of symptoms in certain cases) and, thus, better patient outcomes. 
     An additional, and distinct, advantage of the disclosed compounds, compositions, and methods is that any of the disclosed bio-based compounds can be used in radio-labeled studies. For example, such studies are useful in the study of the metabolism of pharmaceutically active compounds and drug products. The  14 C metabolites and moieties can be traced as they move and/or change as they interact with a living organism. Partially bio-based pharmaceutically active compounds may be especially useful in tracing moieties as the compound is interacting in a biological system and metabolized. The drug structures may be fully bio-based or only partially bio-based where only a portion (typically the aryl group(s)) is bio-based so that different metabolites have different  14 C/ 12 C ratios. 
     Glossary 
     Aromatics—As used herein, the terms “aromatics” or “aromatic compound” are used to refer to a hydrocarbon compound or compounds comprising one or more aromatic groups such as, for example, single aromatic ring systems (e.g., benzyl, phenyl, etc.) and fused polycyclic aromatic ring systems (e.g. naphthyl, 1,2,3,4-tetrahydronaphthyl, etc.). Examples of aromatic compounds include, but are not limited to, benzene, toluene, indane, indene, 2-ethyl toluene, 3-ethyl toluene, 4-ethyl toluene, trimethyl benzene (e.g., 1,3,5-trimethyl benzene, 1,2,4-trimethyl benzene, 1,2,3-trimethyl benzene, etc.), ethylbenzene, styrene, cumene, methylbenzene, propylbenzene, xylenes (e.g., p-xylene, m-xylene, o-xylene), naphthalene, methyl-naphthalene (e.g., 1-methyl naphthalene), anthracene, 9.10-dimethylanthracene, pyrene, phenanthrene, dimethyl-naphthalene (e.g., 1,5-dimethylnaphthalene, 1,6-dimethylnaphthalene, 2,5-dimethylnaphthalene, etc.), ethyl-naphthalene, hydrindene, methyl-hydrindene, and dimethyl-hydrindene. Single-ring and/or higher ring aromatics may also be produced in some embodiments. Aromatics also include single and multiple ring compounds that contain heteroatom substituents, i.e. phenol, cresol, benzofuran, aniline, indole, etc. 
     Biomass—As used herein, the term “biomass” is given its conventional meaning in the art and is used to refer to any organic source of energy or chemicals that is renewable. Its major components can be: (1) trees (wood) and all other vegetation; (2) agricultural products and wastes (corn, fruit, garbage ensilage, etc.); (3) algae and other marine plants; (4) metabolic wastes (manure, sewage), and (5) cellulosic urban waste. Examples of biomass materials are described, for example, in Huber, G. W. et al, “Synthesis of Transportation Fuels from Biomass: Chemistry, Catalysts, and Engineering,” Chem. Rev. 106, (2006), pp. 4044-4098. 
     Biomass has been defined as the living and recently dead biological material that can be converted for use as fuel or for industrial production. The criterion as biomass is that the material should be recently participating in the carbon cycle so that the release of carbon in the combustion process results in no net increase averaged over a reasonably short period of time (for this reason, fossil fuels such as peat, lignite and coal are not considered biomass by this definition as they contain carbon that has not participated in the carbon cycle for a long time so that their combustion results in a net increase in atmospheric carbon dioxide). Most commonly, biomass refers to plant matter grown for use as biofuel, but it also includes plant or animal matter used for production of fibers, chemicals or heat. Biomass may also include biodegradable wastes or byproducts that can be burnt as fuel or converted to chemicals, including municipal wastes, green waste (the biodegradable waste comprised of garden or park waste, such as grass or flower cuttings and hedge trimmings), byproducts of farming including animal manures, food processing wastes, sewage sludge, and black liquor from wood pulp or algae. Biomass excludes organic material which has been transformed by geological processes into substances such as coal, oil shale or petroleum. Biomass is widely and typically grown from plants, including miscanthus, spurge, sunflower, switchgrass, hemp, corn (maize), poplar, willow, sugarcane, and oil palm (palm oil) with the roots, stems, leaves, seed husks and fruits all being potentially useful. Biomass can be distinguished from fossil-derived carbon by the presence of  14 C in amounts significantly above that found in fossil fuels. 
     “Bio-based” means that the carbon in the drug structure or a selected part of the drug structure has been derived from biomass such that the  14 C content in the structure or selected moiety is similar to the  14 C content in living organisms, on the order of 1 part per trillion. The  14 C content can be measured by radiation counting or accelerator mass spectrometry. 
     Catalytic pyrolysis refers to a process for converting hydrocarbonaceous materials to chemicals, fuels, or chemicals and fuels by rapid heating in the presence of a catalyst. Examples of apparatus and process conditions suitable for CFP are described in U.S. Pat. Nos. 8,277,643, and 9,169,442, by Huber et al., and in US Patent Application 2013/0060070A1 by Huber et al. that are incorporated herein by reference. Conditions for catalytic pyrolysis of biomass may include one or any combination of the following features (which are not intended to limit the broader aspects of the invention): a zeolite catalyst, a ZSM-5 catalyst; a zeolite catalyst comprising one or more of the following metals: titanium, vanadium, chromium, manganese, iron, cobalt, nickel, copper, zinc, gallium, platinum, palladium, silver, phosphorus, sodium, potassium, magnesium, calcium, tungsten, zirconium, cerium, lanthanum, and combinations thereof; a fluidized bed, circulating bed, or riser reactor; an operating temperature in the range of 300° to 1000° C.; and/or a solid catalyst-to-biomass mass ratio of between 0.1 and 40. 
     “Compliance,” is a widely understood term which is also known as “adherence,” and refers to the extent to which a patient adheres to a dosing regimen. This is equivalent to the extent to which patients administer a drug product consistently for the prescribed amount of medicine for the prescribed time interval over the course of treatment. Here “prescribed” may mean the prescription of a medical professional (typically a doctor or nurse) or labeled instructions on an over-the-counter medication. Patient compliance for many drug regimens is known to be poor, and even in many cases of drug products for the treatment of life-threatening diseases patient compliance is as low as 50%. Compliance can be measured by conventional means, for example, asking patients about their administration, or testing their urine or blood. For purposes of the present invention, compliance can be measured by asking prospective patients about their compliance under a given set of circumstances, or by asking people, preferably users of the medicine, about the compliance of users generally under a given set of circumstances. In some embodiments, changes in compliance can be calculated, for example, by adding categories such as more likely and much more likely to comply with a dosage regimen minus less likely or much less likely (see  FIG. 2 ). 
     A dosage regimen is the schedule of doses of a medicine, including the time between doses, the duration of treatment and the amount to be taken each time. Dosage regimens also include how a medicine is to be taken, and in what formulation (dosage form). This is the conventional definition and is the definition found in the European&#39;s Patient Academy since at least 2016. 
     As is standard patent terminology, the term “consisting essentially of” excludes the presence of additional steps that would materially affect the method or components that would materially affect the product. In general, any of the inventive methods or products that are defined using the term “comprising” may also be characterized using the more restrictive term “consisting essentially of” or, in the narrowest case, “consisting of.” 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       Table 1 is a listing of small molecule drugs. 
         FIG. 1  is a graph summarizing survey data that shows the percentage of consumers indicating the percentage of plant-based ingredients in a product that would cause them to buy the bio-based medicine. 
         FIG. 2  shows the increase in compliance for bio-based cetirizine anticipated by consumers in Germany, Sweden and the United Kingdom. 
         FIG. 3  shows the increase in compliance for bio-based ibuprofen anticipated by consumers in Germany as compared to conventionally-sourced ibuprofen. 
     
    
    
     DETAILED DESCRIPTION 
     In the present invention, bio-based medicines are synthesized from starting materials that are sourced from renewable sources (as opposed to fossil fuels). There are numerous patents and papers describing methods of making bio-based materials from renewable sources. Preferred starting materials for making pharmaceutical compositions according to the present invention are the aromatic products made by pyrolysis of biomass as described in the Huber patents cited above. To mention another example, Miller et al. in U.S. Pat. No. 9,668,951 (incorporated herein as if reproduced in full below) describe making bio-based 1,3-propanediol in a microbial process. Cukalovic in “Use of microreactor technology and renewable resources to develop green chemical processes,” Ph.D. dissertation, Ghent University, 2012 describes reductive amination of hydroxymethylfuran (HMF) resulting in (5-alkylaminomethyl-2-hydroxmethyl)furan structures that can be converted into 6-substituted 3-pyridinols useful in sensory research or starting materials for further conversions, into various pharmaceuticals or agrochemicals (citing Kohl et al, “The Selection of Pantoprazole as a clinical Candidate,” J. Med. Chem. (1992), vol. 35, Issue 6, pages 1049-1057). Tsolakis et al., in Mapping supply dynamics in renewable feedstock enabled industries: A systems theory perspective on “green” pharmaceuticals, Operations Management Research (2018), Vol. 11, pages 83-104 report that, for the case of paracetamol, an active pharmaceutical ingredient (API) could be manufactured from terpenoid feedstocks, either limonene or β-pinene. The identification of suppliers of limonene-found in significant concentrations in citrus waste—or β-pinene—extracted in substantial volumes from crude sulphate turpentine found in waste from kraft paper and pulp industries. Mahmoud in The selective synthesis of aromatics and furans from biomass-derived compounds, Thesis, 2016, University of Delaware mentions that the Diels-Alder reaction of furans is an important reaction for the conversion of these compounds to aromatic molecules, the synthesis of pharmaceuticals, and a variety of other important molecules. Other publications describing bio-based substances include: Xu et al., Direct production of indoles via thermos-catalytic conversion of bio-derived furans with ammonia over zeolites, Green Chemistry (2015), Vol. 17, pages 1281-1290; Carlson et al., Aromatic Production from Catalytic Fast Pyrolysis of Biomass-derived Feedstock, Topics in Catalysis (2004), vol. 52, pages 241-252. 
     Testing methods for bio-based carbon are well known. ASTM D6866-18, Entitled Standard Test Methods for Determining the Biobased Content of Solid, Liquid, and Gaseous Samples Using Radiocarbon Analysis, provides accurate biobased/biogenic carbon content results to materials whose carbon source was directly in equilibrium with C02 in the atmosphere at the time of cessation of respiration or metabolism, such as the harvesting of a crop or grass living its natural life in a field. Liquid Scintillation Counting is an older technique that can be used to analyze the distribution of  14 C in a compound; see, for example, Kent et al., “A Method for Obtaining the  14 C-Isotope Distribution in Malate (C-2,3),” Anal. Biochem. 80, 176-182 (1977). More recently, accelerator mass spectrometry can be used to analyze the distribution of  14 C in a compound. In the present invention, partially bio-based compounds can be used to study metabolic transformations, transport and/or distribution of medicines. This can be done by administering to a human or non-human subject, a fully bio-based, or, preferentially, a partially bio-based compound; then collecting the samples from within the body or excreted from the body. Typically, the samples will be concentrated (if necessary, collected from multiple subjects and concentrated) and analyzed for the presence, concentration and/or distribution of  14 C. If desired, the results can be compared with a conventional, non-bio-based medicine having the same structure. 
     In some preferred embodiments of the present invention, aromatic starting materials are provided by the pyrolysis of biomass (preferably the pyrolysis of plant materials); for example, by the methods of Huber et al. incorporated herein. Thus, preferred starting materials include bio-based benzene, toluene and xylenes. Other aromatic starting materials such as naphthalene and thiophene may be used and are also derivable from the pyrolysis of biomass. 
     In an inventive aspect, a pharmaceutically effective dose of a bio-based or partially bio-based pharmaceutically active compound or pharmaceutical composition is provided. In some embodiments, the dose comprises a pharmaceutical composition comprising any one of the pharmaceutically active compounds shown in Table 1. The composition can be the pure active ingredient or can be a mixture with inert and/or other pharmacologically active compounds. The compound can be selected from any one of the compounds shown in Table 1. To provide one example, the pharmaceutically effective dose of a bio-based or partially bio-based lansoprazol molecule, depicted below. 
     
       
         
         
             
             
         
       
     
     This compound can be fully bio-based, or where only the phenyl group (not the pyridine group) is bio-based; or where at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, or at least 90%, or from 30% to 90%, or from 30% to 80%, or from 40% to 90%, or from 50% to 100% of the carbon atoms in the lansoprazole structure are bio-based. The compound can be substantially completely bio-based. Each of compounds in Table 1, one at a time, replacing “lansoprazol” in the example above, is contemplated. 
     Thus, in another example, a pharmaceutically effective dose of a bio-based or partially bio-based cetirizine is provided, as depicted below: 
     
       
         
         
             
             
         
       
     
     This compound can be fully bio-based, or where only the phenyl groups are bio-based; or where at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, or at least 90%, or from 30% to 90%, or from 30% to 80%, or from 40% to 90%, or from 50% to 100% of the carbon atoms in the cetirizine structure are bio-based. The compound can be substantially completely bio-based. Each of compounds in Table 1, one at a time, replacing “cetirizine” in the example above, is contemplated. 
     
       
         
         
             
             
         
       
     
     From the above synthesis of cetirizine, it can be readily seen that, in some preferred embodiments, the present invention provides cetirizine in which 12/20 of the carbon atoms (the carbon in the aryl groups) is bio-based, or 13/20 carbon atoms (including the tertiary carbon). Higher percentages can be provided via the use of non-aromatic bio-based compounds. 
     An alternative approach to citrizine dihydrochloride starts from 4-chlorobenzyl chloride (Guangdong Huagong, 2008, 35, 66-67) (Scheme 2). 
     
       
         
         
             
             
         
       
     
     The most common approaches to cetirizine dihydrochloride utilize chemistry that incorporate 4-chlorobenzophenone or 4-chlorobenzhydrol. A selection of routes is shown below (Scheme 3) 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     The basic chemicals used in the above chemistries could be sourced from benzene or toluene—examples are shown in Scheme 4. 
     
       
         
         
             
             
         
       
     
     Synthesis of Chlorhexidine (Chlohexamed Forte) 
     
       
         
         
             
             
         
       
     
     From this synthesis of chorhexidine it can be seen that, in some preferred embodiments, the present invention provides chlorhexidine in which 12/22 of the carbon atoms (the carbon in the aryl groups) is bio-based, or higher if bio-based alkyl amines are used.
 
Intermediate 4-Chloroaniline from Benzene:
 
     
       
         
         
             
             
         
       
     
     
       
         
         
             
             
         
       
     
     Intermediate 2-Nitrobenzaldehyde from Toluene:
 
Step 1: Gerald Booth (2007). “Nitro Compounds, Aromatic”. Ullmann&#39;s Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH.
 
Step 2: Lauth, Bull. Soc. Chim. France, (3) 31, 133 (1904).
 
     
       
         
         
             
             
         
       
     
     From the above synthesis of ambroxol, it can be seen that, in some preferred embodiments, the present invention provides ambroxol in which 7/13 of the carbon atoms (the carbon in the toluene group) is bio-based, or higher if bio-based nonaromatic starting materials are used. 
     Synthesis of Bisacodyl (Ducolax) 
     Scheme 1. Kottler et al. U.S. Pat. No. 2,764,590 Certain 4, 4′-disubstituted-diphenylpyridyl methanes and process. 
     
       
         
         
             
             
         
       
     
     From the above synthesis of bisacodyl, it can be seen that, in some preferred embodiments, the present invention provides chlorhexidine in which 12/22 of the carbon atoms (the carbon in the aryl groups) is bio-based, or 16/22 including bio-based acetic anhydride.
 
Intermediate Phenol from Toluene
 
     
       
         
         
             
             
         
       
     
     Synthesis of Xylomethazoline (Olynth) 
     
       
         
         
             
             
         
       
     
     Intermediate Para-Tertiary-Butyl-Ortho:Ortho′-Dimethyl-Phenyl-Acetonitrile from m-Xylene. 
     
       
         
         
             
             
         
       
     
     From the above synthesis of xylomethazoline, it can be seen that, in some preferred embodiments, the present invention provides xylomethazoline in which 8/14 of the carbon atoms (the carbon from xylene) is bio-based, or 10/14 including bio-based alkyl amine. 
     Synthesis of Diclofenac (Forte Voltaren) 
     
       
         
         
             
             
         
       
     
     From the synthesis of Diclofenac, it can be seen that, in some preferred embodiments, the present invention provides Diclofenac in which 13/14 of the carbon atoms (the carbon from benzene and toluene) is bio-based, or 14/14 including bio-based compound to result in the carboxylic acid group. 
     Intermediates: 
     2,6-Dichloroaniline from Benzene 
     
       
         
         
             
             
         
       
     
     2-Chlorophenylacetic Acid from Toluene 
     
       
         
         
             
             
         
       
     
     Synthesis of Clotrimazole (Canesten) 
     
       
         
         
             
             
         
       
     
     From the synthesis of Clotrimazole, it can be seen that, in some preferred embodiments, the present invention provides Clotrimazole in which 17/20 of the carbon atoms are bio-based.
 
Intermediate 2-Chlorobenzotrichloride from Toluene
 
     
       
         
         
             
             
         
       
     
     Synthesis of Omeprazole (Omep Hexal) 
     
       
         
         
             
             
         
       
     
     Intermediates: 4-methoxy-2,3,5-trimethylpyridine from (Z)-3-Amino-2-methyl-2-butenoic Acid Ethyl Ester and Diethyl Methylmalonate 
     
       
         
         
             
             
         
       
     
     From the above synthesis of Omeprazole, it can be seen that, in some preferred embodiments, the present invention provides Omeprazole in which 6/17 of the carbon atoms are bio-based; higher concentrations of bio-based carbon atoms can be obtained from bio-based nonaromatic compounds. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     Synthesis of Flurbiprofen (Dobendan) 
     
       
         
         
             
             
         
       
     
     From the above synthesis of Flurbiprofen, it can be seen that, in some preferred embodiments, the present invention provides Flurbiprofen in which 6/15 of the carbon atoms are bio-based (from the aryl group in phenylboronic acid); or 12/15 if both aryl groups are bio-based. 
     Intermediate Phenylboronic Acid from Benzene: 
     
       
         
         
             
             
         
       
     
     Synthesis of Naproxen (Dolormin) 
     
       
         
         
             
             
         
       
     
     Intermediate 6-Methoxy-2-Naphthylacetic Acid from Naphthalene: 
     
       
         
         
             
             
         
       
     
     From the above synthesis of Naproxen, it can be seen that, in some preferred embodiments, the present invention provides Naproxen in which 10/14 of the carbon atoms are bio-based (from the naphthalene); or 11/14 or 14/14 via the use of bio-based reagents. 
     Synthesis of Doxilamine (Hoggar) 
     
       
         
         
             
             
         
       
     
     From the above synthesis of Doxilamine, it can be seen that, in some preferred embodiments, the present invention provides Doxilamine in which 6/17 of the carbon atoms are bio-based (from benzene); or 10/17 or more via the use of bio-based reagents. 
     Synthesis of Ioperamide 
     
       
         
         
             
             
         
       
     
     Intermediate (3,3-Diphenyloxolan-2-Ylidene)-Dimethylazanium,Bromide from Benzene
 
From the synthesis of Ioperamide, it can be seen that, in some preferred embodiments, the present invention provides Ioperamide in which 18/29 of the carbon atoms are bio-based (from aryl groups); or 16/29 or 22/29 (including bio-based ethyl acetate) or more via the use of bio-based reagents.
 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     In another example, a pharmaceutically effective dose of a bio-based or partially bio-based mephentermine is disclosed, as depicted below. 
     
       
         
         
             
             
         
       
     
     This compound can be fully bio-based, or where only the phenyl group is bio-based; or where at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, or at least 90%, or from 30% to 90%, or from 30% to 80%, or from 40% to 90%, or from 50% to 100% of the carbon atoms in the mephentermine structure are bio-based. The compound can be substantially completely bio-based. Each of compounds in Table 1, one at a time, replacing “mephentermine” in the example above, is contemplated. 
     In another preferred embodiment, the active compound is ibuprofen: 
     
       
         
         
             
             
         
       
     
     This compound can be fully bio-based, or where only the phenyl group is bio-based; or where at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, or at least 90%, or from 30% to 90%, or from 30% to 80%, or from 40% to 90%, or from 50% to 100% of the carbon atoms in the ibuprofen structure are bio-based. The compound can be substantially completely bio-based. 
     In another embodiment, a method is disclosed of treating a patient comprising administering or prescribing a pharmaceutically effective dose of a bio-based, or partially bio-based, pharmaceutically active compound or pharmaceutical composition. In some embodiments, the patient is aware of or otherwise knows that the compound or composition is bio-based. In some cases, the method includes a step of informing the patient that the composition comprises a bio-based active ingredient. The patient can be informed verbally or in writing (such as via a label), or both. 
     In another embodiment, a method is disclosed of treating a patient wherein the bio-based pharmaceutically effective material is used in a treatment with another drug or drugs, either as a common dosage comprising both materials, or in a sequential treatment wherein the bio-based material and other material(s) are administered in a regimen that includes both materials. 
     Compositions that are disclosed can contain a conventional pharmaceutically active compound in addition to a bio-based pharmaceutically active compound. 
     This disclosure is not limited to any particular method or methods by which the pharmaceutically active compound are made. Typically, the inventive structures are made using products obtained by pyrolyzing biomass in the presence of a catalyst. The catalyzed pyrolysis process can be conducted to produce high yields of aromatics, especially benzene, toluene, and xylenes. The subsequent use of these bio-based aromatics in the synthesis of drug structures can produce drug structures in which the aromatic rings (optionally with attached methyl or methoxy groups) are bio-based. 
     The partially or fully bio-based compounds and compositions described herein replace conventional pharmaceutical compounds and compositions that are derived from petro-chemicals. Most “natural products” are merely identified based on their presence in nature, but are prepared via petrochemical-based synthetic chemical processes at a commercial-scale. The rare commercially-available pharmaceutically active compound that is prepared via fermentation process or via extraction from a natural source would be “bio-sourced” (and have the telltale isotopic  14 C/ 12 C ratio) and these commercially-available pharmaceutically active compound are not included in the subject matter being claimed; although with respect to the commercially-available pharmaceutically active compounds that are only partially bio-sourced; partially or fully bio-based compounds and compositions that have a higher mass % of bio-based carbon are included in the subject matter being claimed. 
     In some preferred embodiments, the drug structure is cetirizine or other antihistamine that contains an aromatic ring structure. In some preferred embodiments, the drug structure is produced using at least in part bio-based benzene, toluene, or xylene, or C9+ aromatics or some mixture of these. In some embodiments, the pharmaceutically effective dose is in the form of a tablet, capsule, injectable or other dosage form having a mass of drug of at least 0.1 mg, or at least 0.5 mg, or at least 1 mg, or at least 5 mg or at least 10 mg, or from 0.01 to 10 mg, or from 0.5 to 5 mg. 
     Examples—Patient Compliance 
     A survey was conducted of 101 residents of the United Kingdom (UK), 106 German (DE) residents, and 63 Swedish (SE) residents, all of whom use Cetirizine. The people in this survey were asked a series of questions about Cetirizine. As can be seen in  FIG. 1 , a higher percentage of plant material in the Cetirizine would lead more people to purchase the bio-based medicine. The people in the survey were also asked “Do you think you would be more likely to finish a complete course of your medication if it was manufactured from environmentally-friendly renewable raw plant materials than the same medication that was made from standard materials/synthetic chemicals? Please rank on a scale of 1-5 where 1 is much less likely and 5 is much more likely.” From this question, it was discovered, very surprisingly, that bio-based Cetirizine, would increase compliance (adherence), making people between 4800 and 67% more likely or much more likely to comply with taking the medication. These results are shown in  FIG. 2 . 
     A similar result was obtained for the drug ibuprofen. After being shown packaging for ibuprofen made with 50% plant raw materials, respondents were asked whether a “patient would more likely, as likely, or less likely . . . to be compliant to take his/her medication versus usual medication.” As can be seen in  FIG. 3 , a survey of 405 German residents surprisingly showed that 45 of respondents thought that patients would be more compliant in taking the bio-based medication. 
     Thus, the data shows that the use of bio-based medicines (which possess an elevated  14 C/ 12 C ratio relative to fossil fuels) lead to surprisingly improved levels of patient compliance. 
     
       
         
           
               
               
             
               
                   
                 TABLE 1 
               
               
                   
                   
               
               
                   
                 Molecular formula 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 foscarnet; Phosphonoformic acid; Phosphonoformate . . . 
                 CH3O5P 
               
               
                 Clodronate; Clodronic acid; Dichloromethanediphosphonic acid . . . 
                 CH4Cl2O6P2 
               
               
                 Etidronic acid; etidronate; HEDP . . . 
                 C2H8O7P2 
               
               
                 halothane; Fluothane; Narcotan . . . 
                 C2HBrClF3 
               
               
                 pamidronate; PAMIDRONIC acid; Amidronate . . . 
                 C3H11NO7P2 
               
               
                 enflurane; Ethrane; Methylflurether . . . 
                 C3H2ClF5O 
               
               
                 isoflurane; Forane; Aerrane . . . 
                 C3H2ClF5O 
               
               
                 Suprane; DESFLURANE; Desfluranum [INN-Latin] . . . 
                 C3H2F6O 
               
               
                 methoxyflurane; Penthrane; Anecotan . . . 
                 C3H4Cl2F2O 
               
               
                 nitroglycerin; Nitrostat; Glyceryl trinitrate . . . 
                 C3H5N3O9 
               
               
                 FOSFOMYCIN; phosphomycin; Phosphonomycin . . . 
                 C3H7O4P 
               
               
                 fosmidomycin; Fosmidomycina; Fosmidomycine . . . 
                 C4H10NO5P 
               
               
                 metformin; Glucophage; Glumetza . . . 
                 C4H11N5 
               
               
                 TROMETHAMINE; Trometamol; Tris . . . 
                 C4H11NO3 
               
               
                 alendronate; ALENDRONIC acid; Fosamax . . . 
                 C4H13NO7P2 
               
               
                 sevoflurane; Ultane; Sevofluran . . . 
                 C4H3F7O 
               
               
                 5-Fluorouracil; fluorouracil; 5-FU . . . 
                 C4H3FN2O2 
               
               
                 methimazole; thiamazole; Tapazole . . . 
                 C4H6N2S 
               
               
                 acetazolamide; Diamox; Diacarb . . . 
                 C4H6N4O3S2 
               
               
                 Zoledronic acid; Zoledronate; Reclast . . . 
                 C5H10N2O7P2 
               
               
                 mechlorethamine; Chlormethine; Nitrogen mustard . . . 
                 C5H11Cl2N 
               
               
                 D-Penicillamine; Cuprimine; Depen . . . 
                 C5H11NO2S 
               
               
                 Acamprosate; N-Acetylhomotaurine; Campral . . . 
                 C5H11NO4S 
               
               
                 Orotic acid; 6-Carboxyuracil; Orodin . . . 
                 C5H4N2O4 
               
               
                 allopurinol; Zyloprim; Lopurin . . . 
                 C5H4N4O 
               
               
                 6-Mercaptopurine; mercaptopurine; Purinethol . . . 
                 C5H4N4S 
               
               
                 pyrazinamide; pyrazinecarboxamide; pyrazinoic acid amide . . . 
                 C5H5N3O 
               
               
                 6-Thioguanine; thioguanine; Tioguanine . . . 
                 C5H5N5S 
               
               
                 methazolamide; Methenamide; Neptazaneat . . . 
                 C5H8N4O3S2 
               
               
                 carmustine; BCNU; Carmustin . . . 
                 C5H9Cl2N3O2 
               
               
                 histamine; 1H-Imidazole-4-ethanamine; 2-(4-Imidazolyl)ethylamine . . . 
                 C5H9N3 
               
               
                 BETAZOLE; Ametazole; 1H-Pyrazole-3-ethanamine . . . 
                 C5H9N3 
               
               
                 L-proline; proline; L-(−)-Proline . . . 
                 C5H9NO2 
               
               
                 N-Acetyl-L-cysteine; acetylcysteine; N-Acetylcysteine . . . 
                 C5H9NO3S 
               
               
                 L-glutamic acid; L-glutamate; glutacid . . . 
                 C5H9NO4 
               
               
                 MEGLUTOL; 3-Hydroxy-3-methylglutaric acid; Dicrotalic acid . . . 
                 C6H10O5 
               
               
                 vigabatrin; Sabril; gamma-Vinyl GABA . . . 
                 C6H11NO2 
               
               
                 6-aminohexanoic acid; aminocaproic acid; 6-Aminocaproic acid . . . 
                 C6H13NO2 
               
               
                 Isofagomine; Afegostat; (3R,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE- 
                 C6H13NO3 
               
               
                 3,4-DIOL . . . 
               
               
                 L-lysine; lysine; lysine acid . . . 
                 C6H14N2O2 
               
               
                 L-arginine; arginine; L-(+)-Arginine . . . 
                 C6H14N4O2 
               
               
                 busulfan; Myleran; Busulphan . . . 
                 C6H14O6S2 
               
               
                 Carbacholin; Carbacholine; Carbacolina . . . 
                 C6H15N2O2+ 
               
               
                 dichlorphenamide; Diclofenamide; Dichlofenamide . . . 
                 C6H6Cl2N2O4S2 
               
               
                 lindane; Kwell; beta-BHC . . . 
                 C6H6Cl6 
               
               
                 nicotinamide; niaClnamide; 3-Pyridinecarboxamide . . . 
                 C6H6N2O 
               
               
                 temozolomide; Methazolastone; Temodar . . . 
                 C6H6N6O2 
               
               
                 isoniazid; Isonicotinic acid hydrazide; Isonicotinohydrazide . . . 
                 C6H7N3O 
               
               
                 AMILORIDE; Amipramidin; Midamor . . . 
                 C6H8ClN7O 
               
               
                 sulfanilamide; 4-Aminobenzenesulfonamide; Sulphanilamide . . . 
                 C6H8N2O2S 
               
               
                 ascorbic acid; I-ascorbic acid; vitamin C . . . 
                 C6H8O6 
               
               
                 citric acid; Citro; citrate . . . 
                 C6H8O7 
               
               
                 metronidazole; Flagyl; Metronidazol . . . 
                 C6H9N3O3 
               
               
                 trimethadione; Troxidone; Tridione . . . 
                 C6H9NO3 
               
               
                 ISOSORBIDE MONONITRATE; Monoket; Imdur . . . 
                 C6H9NO6 
               
               
                 Carbimazole; Athyromazole; Carbimazol . . . 
                 C7H10N2O2S 
               
               
                 propylthiouracil; 6-Propyl-2-thiouracil; Procasil . . . 
                 C7H10N2OS 
               
               
                 ethosuximide; Zarontin; Etosuximida . . . 
                 C7H11NO2 
               
               
                 PARAMETHADIONE; Paradione; Isoethadione . . . 
                 C7H11NO3 
               
               
                 Risedronate; Risedronic acid; 105462-24-6 . . . 
                 C7H11NO7P2 
               
               
                 cyclophosphamide; Cyclophosphamid; Procytox . . . 
                 C7H15Cl2N2O2P 
               
               
                 ifosfamide; Isophosphamide; Iphosphamide . . . 
                 C7H15Cl2N2O2P 
               
               
                 L-carnitine; Levocarnitine; Carnitor . . . 
                 C7H15NO3 
               
               
                 chlorzoxazone; Paraflex; Biomioran . . . 
                 C7H4ClNO2 
               
               
                 chlorothiazide; Diuril; Chlotride . . . 
                 C7H6ClN3O4S2 
               
               
                 salicylic acid; 2-Hydroxybenzoic acid; o-hydroxybenzoic acid . . . 
                 C7H6O3 
               
               
                 5-Aminosalicylic acid; mesalamine; Mesalazine . . . 
                 C7H7NO3 
               
               
                 hydrochlorothiazide; Hypothiazide; Esidrix . . . 
                 C7H8ClN3O4S2 
               
               
                 ethchlorvynol; Ethchlorovynol; Placidyl . . . 
                 C7H9ClO 
               
               
                 Emtricitabine; Coviracil; Emtriva . . . 
                 C8H10FN3O3S 
               
               
                 sulfacetamide; Sulphacetamide; Acetosulfamine . . . 
                 C8H10N2O3S 
               
               
                 ethionamide; Trecator; Ethioniamide . . . 
                 C8H10N2S 
               
               
                 ENPROFYLLINE; 3-Propylxanthine; 3-n-Propylxanthine . . . 
                 C8H10N4O2 
               
               
                 lamivudine; Epivir; Zeffix . . . 
                 C8H11N3O3S 
               
               
                 acyclovir; Acycloguanosine; Aciclovir . . . 
                 C8H11N5O3 
               
               
                 dopamine; Hydroxytyramin; intropin . . . 
                 C8H11NO2 
               
               
                 pyridoxine; Pyridoxol; Gravidox . . . 
                 C8H11NO3 
               
               
                 norepinephrine; noradrenaline; Arterenol . . . 
                 C8H11NO3 
               
               
                 betahistine; 2-(2-METHYLAMINOETHYL)PYRIDINE; Vasomotal . . . 
                 C8H12N2 
               
               
                 Phenelzine; Phenethylhydrazine; Nardil . . . 
                 C8H12N2 
               
               
                 barbital; Barbitone; Veronal . . . 
                 C8H12N2O3 
               
               
                 Decitabine; 5-Aza-2′-deoxycytidine; Dacogen . . . 
                 C8H12N4O4 
               
               
                 ribavirin; Tribavirin; Virazole . . . 
                 C8H12N4O5 
               
               
                 5-azacytidine; Azacitidine; Azacytidine . . . 
                 C8H12N4O5 
               
               
                 LEVETIRACETAM; Levetiracetam [INN]; Levetiracetamum [INN-Latin] 
                 C8H14N2O2 
               
               
                 famotidine; PEPCID; Famodil . . . 
                 C8H15N7O2S3 
               
               
                 VALPROIC acid; 2-Propylpentanoic acid; Depakene . . . 
                 C8H16O2 
               
               
                 Pregabalin; Lyrica; 3-isobutyl GABA . . . 
                 C8H17NO2 
               
               
                 MIGLITOL; Glyset; 72432-03-2 . . . 
                 C8H17NO5 
               
               
                 riluzole; Rilutek; 1744-22-5 . . . 
                 C8H5F3N2OS 
               
               
                 diazoxide; Proglycem; Eudemine . . . 
                 C8H7ClN2O2S 
               
               
                 furazolidone; Furoxone; Furazolidine . . . 
                 C8H7N3O5 
               
               
                 guanabenz; Wy 8678 base; Wytensin . . . 
                 C8H8Cl2N4 
               
               
                 trichlormethiazide; Trichloromethiazide; Naqua . . . 
                 C8H8Cl3N3O4S2 
               
               
                 hydroflumethiazide; Diuredemina; Diurometon . . . 
                 C8H8F3N3O4S2 
               
               
                 zonisamide; Zonegran; Exceglan . . . 
                 C8H8N2O3S 
               
               
                 hydralazine; 1-Hydrazinophthalazine; Apresolin . . . 
                 C8H8N4 
               
               
                 acetaminophen; Paracetamol; 4-Acetamidophenol . . . 
                 C8H9NO2 
               
               
                 CLAVULANIC acid; Clavulanate; Antibiotic MM 14151 . . . 
                 C8H9NO5 
               
               
                 Bivalirudin; Angiomax; Hirulog . . . 
                 C98H138N24O33 
               
               
                 apraclonidine; lopidine; 4-Aminoclonidine . . . 
                 C9H10Cl2N4 
               
               
                 phenacemide; Phenuron; Phenurone . . . 
                 C9H10N2O2 
               
               
                 aminohippuric acid; 4-Aminohippuric acid; P-AMINOHIPPURIC acid . . . 
                 C9H10N2O3 
               
               
                 sulfamethizole; Sulphamethizole; Sulfamethizol . . . 
                 C9H10N4O2S2 
               
               
                 methyclothiazide; Aquatensen; Enduron . . . 
                 C9H11Cl2N3O4S2 
               
               
                 gemcitabine; dFdC; Gemcin . . . 
                 C9H11F2N3O4 
               
               
                 floxuridine; 2′-Deoxy-5-fluorouridine; FUDR . . . 
                 C9H11FN2O5 
               
               
                 idoxuridine; 5-lodo-2′-deoxyuridine; Stoxil . . . 
                 C9H11IN2O5 
               
               
                 benzocaine; Ethyl 4-aminobenzoate; Americaine . . . 
                 C9H11NO2 
               
               
                 L-phenylalanine; phenylalanine; 3-Phenyl-L-alanine . . . 
                 C9H11NO2 
               
               
                 L-tyrosine; tyrosine; (S)-Tyrosine . . . 
                 C9H11NO3 
               
               
                 levodopa; L-dopa; Dopar . . . 
                 C9H11NO4 
               
               
                 dextroamphetamine; Dexamphetamine; D-Amphetamine . . . 
                 C9H13N 
               
               
                 iproniazid; Marsilid; Rivivol . . . 
                 C9H13N3O 
               
               
                 zalcitabine; Dideoxycytidine; 2′,3′-DIDEOXYCYTIDINE . . . 
                 C9H13N3O3 
               
               
                 cytarabine; Ara-C; Cytosine arabinoside . . . 
                 C9H13N3O5 
               
               
                 ganciclovir; Cytovene; Gancyclovir . . . 
                 C9H13N5O4 
               
               
                 phenylpropanolamine; Norephedrine; Rhindecon . . . 
                 C9H13NO 
               
               
                 ethinamate; Ethinamat; Valmid . . . 
                 C9H13NO2 
               
               
                 metaraminol; L-Metaraminol; Hydroxynorephedrine . . . 
                 C9H13NO2 
               
               
                 phenylephrine; Neosynephrine; Mezaton . . . 
                 C9H13NO2 
               
               
                 levonordefrin; Nordefrin; Neo-Cobefrin . . . 
                 C9H13NO3 
               
               
                 epinephrine; Adrenalin; I-Adrenaline . . . 
                 C9H13NO3 
               
               
                 metharbital; Gemonil; Methylbarbital . . . 
                 C9H14N2O3 
               
               
                 minoxidil; Loniten; Rogaine . . . 
                 C9H15N5O 
               
               
                 Kuvan; 5,6,7,8-tetrahydrobiopterin; tetrahydrobiopterin . . . 
                 C9H15N5O3 
               
               
                 captopril; Capoten; Cesplon . . . 
                 C9H15NO3S 
               
               
                 lomustine; Belustine; CeeNU . . . 
                 C9H16ClN3O2 
               
               
                 azelaic acid; NONANEDIOIC acid; Finacea . . . 
                 C9H16O4 
               
               
                 gabapentin; Neurontin; Gabapentine . . . 
                 C9H17NO2 
               
               
                 meprobamate; Amepromat; Equanil . . . 
                 C9H18N2O4 
               
               
                 altretamine; Hexalen; Hexastat . . . 
                 C9H18N6 
               
               
                 Ibandronic acid; Ibandronate; Bondronat . . . 
                 C9H23NO7P2 
               
               
                 haloprogin; Halotex; Mycanden . . . 
                 C9H4Cl3IO 
               
               
                 chloroxine; 5,7-Dichloro-8-hydroxyquinoline; Capitrol . . . 
                 C9H5Cl2NO 
               
               
                 clioquinol; lodochlorhydroxyquin; Vioform . . . 
                 C9H5ClINO 
               
               
                 lamotrigine; Lamictal; Lamictal Cd . . . 
                 C9H7Cl2N5 
               
               
                 azathioprine; Imuran; Azothioprine . . . 
                 C9H7N7O2S 
               
               
                 tizanidine; Sirdalud; Ternelin . . . 
                 C9H8ClN5S 
               
               
                 clonidine; Duraclon; Chlornidinum . . . 
                 C9H9Cl2N3 
               
               
                 GUANFACINE; Estulic; Intuniv . . . 
                 C9H9Cl2N3O 
               
               
                 sulfadiazine; Sulphadiazine; Sulfapyrimidine . . . 
                 C10H10N402S 
               
               
                 Clofarabine; Clolar; Evoltra . . . 
                 C10H11ClFN5O3 
               
               
                 Trifluridine; Viroptic; TRIFLUOROTHYMIDINE . . . 
                 C10H11F3N2O5 
               
               
                 sulfamethoxazole; Sulfisomezole; Gantanol . . . 
                 C10H11N3O3S 
               
               
                 QUINETHAZONE; Chinethazonum; Quinethazon . . . 
                 C10H12ClN3O3S 
               
               
                 Cladribine; 2-Chloro-2′-deoxyadenosine; Leustatin . . . 
                 C10H12ClN5O3 
               
               
                 baclofen; Lioresal; Baclon . . . 
                 C10H12ClNO2 
               
               
                 tolazoline; Priscoline; 2-Benzylimidazoline . . . 
                 C10H12N2 
               
               
                 stavudine; sanilvudine; Zerit . . . 
                 C10H12N2O4 
               
               
                 didanosine; DIDEOXYINOSINE; Videx . . . 
                 C10H12N4O3 
               
               
                 Tazobactam; 89786-04-9; CHEMBL404 . . . 
                 C10H12N4O5S 
               
               
                 chlorpropamide; Chloropropamide; Diabinese . . . 
                 C10H13ClN2O3S 
               
               
                 fludarabine phosphate; fludara; FAMP . . . 
                 C10H13FN5O7P 
               
               
                 Debrisoquine; Debrisoquin; Debrisochinum . . . 
                 C10H13N3 
               
               
                 Vidarabine; Ara-A; Vira-A . . . 
                 C10H13N5O4 
               
               
                 zidovudine; Azidothymidine; Retrovir . . . 
                 C10H13N5O4 
               
               
                 adenosine; Adenocard; Adenoscan . . . 
                 C10H13N5O4 
               
               
                 Tenamfetamine; 3,4-methylenedioxyamphetamine; 
                 C10H13NO2 
               
               
                 Methylenedioxyamphetamine . . . 
               
               
                 phenacetin; Acetophenetidin; Acetophenetin . . . 
                 C10H13NO2 
               
               
                 Metirosine; METYROSINE; Methyltyrosine . . . 
                 C10H13NO3 
               
               
                 methyldopa; Aldomet; Alphamethyldopa . . . 
                 C10H13NO4 
               
               
                 Black leaf; L-Nicotine; Nicocide . . . 
                 C10H14N2 
               
               
                 APROBARBITAL; Alurate; Allypropymal . . . 
                 C10H14N2O3 
               
               
                 carbidopa; Lodosyn; N-Aminomethyldopa . . . 
                 C10H14N2O4 
               
               
                 Telbivudine; Tyzeka; L-Thymidine . . . 
                 C10H14N2O5 
               
               
                 dyphylline; Diprophylline; Glyphylline . . . 
                 C10H14N4O4 
               
               
                 5′-adenylic acid; adenylic acid; Adenosine monophosphate . . . 
                 C10H14N5O7P 
               
               
                 METHAMPHETAMINE; Metamfetamine; d-Deoxyephedrine . . . 
                 C10H15N 
               
               
                 phentermine; Duromine; Ionamin . . . 
                 C10H15N 
               
               
                 PHENFORMIN; Phenformine; Fenformin . . . 
                 C10H15N5 
               
               
                 penciclovir; Denavir; Vectavir . . . 
                 C10H15N5O3 
               
               
                 PSEUDOEPHEDRINE; Isoephedrine; d-Pseudoephedrine . . . 
                 C10H15NO 
               
               
                 pipobroman; Vercyte; Amedel . . . 
                 C10H16Br2N2O2 
               
               
                 butabarbital; Secbutabarbital; Butisol . . . 
                 C10H16N2O3 
               
               
                 dorzolamide; 1cil; Trusopt (TN) . . . 
                 C10H16N2O4S3 
               
               
                 EDTA; Edetic acid; Ethylenediaminetetraacetic acid . . . 
                 C10H16N2O8 
               
               
                 cimetidine; Tagamet; Cimetag . . . 
                 C10H16N6S 
               
               
                 amantadine; 1-Adamantanamine; 1-Aminoadamantane . . . 
                 C10H17N 
               
               
                 Dexpramipexole; 104632-28-2; Pramipexol . . . 
                 C10H17N3S 
               
               
                 methyprylon; Noludar; Metiprilon . . . 
                 C10H17NO2 
               
               
                 GUANADREL; Hylorel; Guanadrelum [INN-Latin] . . . 
                 C10H19N3O2 
               
               
                 disulfiram; Tetraethylthiuram disulfide; Antabuse . . . 
                 C10H20N2S4 
               
               
                 I-Menthol; (−)-menthol; Levomenthol . . . 
                 C10H20O 
               
               
                 diethylcarbamazine; Carbamazine; Hetrazan . . . 
                 C10H21N3O 
               
               
                 Miglustat; Zavesca; N-Butylmoranoline . . . 
                 C10H21NO4 
               
               
                 voglibose; Basen; Glustat . . . 
                 C10H21NO7 
               
               
                 GUANETHIDINE; Ismelin; Oktadin . . . 
                 C10H22N4 
               
               
                 anagrelide; Anagrelida; Anagrelidum . . . 
                 C10H7Cl2N3O 
               
               
                 thiabendazole; Tiabendazole; Mintezol . . . 
                 C10H7N3S 
               
               
                 Pemirolast; Pemirolastum [INN-Latin]; Pemirolast [INN] . . . 
                 C10H8N6O 
               
               
                 Amrinone; inamrinone; Inocor . . . 
                 C10H9N3O 
               
               
                 brimonidine; Bromoxidine; 59803-98-4 . . . 
                 C11H10BrN5 
               
               
                 METOPRINE; Methodichlorophen; DDMP . . . 
                 C11H10Cl2N4 
               
               
                 flutamide; Eulexin; Niftolide . . . 
                 C11H11F3N2O3 
               
               
                 sulfapyridine; Sulphapyridine; 2-Sulfapyridine . . . 
                 C11H11N3O2S 
               
               
                 Lofexidine; Britlofex; Lofexidinum [INN-Latin] . . . 
                 C11H12Cl2N2O 
               
               
                 chlormezanone; Chlormethazanone; Trancopal . . . 
                 C11H12ClNO3S 
               
               
                 antipyrine; Phenazone; Anodynin . . . 
                 C11H12N2O 
               
               
                 ethotoin; Peganone; Ethotoine [INN-French] . . . 
                 C11H12N2O2 
               
               
                 L-tryptophan; tryptophan; Tryptophane . . . 
                 C11H12N2O2 
               
               
                 ZILEUTON; Zyflo; Leutrol . . . 
                 C11H12N2O2S 
               
               
                 levamisole; L-Tetramisole; Lepuron . . . 
                 C11H12N2S 
               
               
                 sulfamerazine; Sulphamerazine; Sulfamethyldiazine . . . 
                 C11H12N4O2S 
               
               
                 SULFALENE; Sulfamethopyrazine; Kelfizina . . . 
                 C11H12N4O3S 
               
               
                 polythiazide; Renese; Drenusil . . . 
                 C11H13ClF3N3O4S3 
               
               
                 pargyline; Eudatin; Paragyline . . . 
                 C11H13N 
               
               
                 sulfisoxazole; Sulfafurazole; Sulphafurazole . . . 
                 C11H13N3O3S 
               
               
                 felbamate; Felbatol; Felbamyl . . . 
                 C11H14N2O4 
               
               
                 Nelarabine; Nelzarabine; Arranon . . . 
                 C11H15N5O5 
               
               
                 phenmetrazine; 3-Methyl-2-phenylmorpholine; Oxazimedrine . . . 
                 C11H15NO 
               
               
                 Brolamfetamine; 4-Bromo-2,5-dimethoxyamphetamine; DOB-4 . . . 
                 C11H16BrNO2 
               
               
                 proguanil; Chloroguanide; Chlorguanide . . . 
                 C11H16ClN5 
               
               
                 tocainide; Tonocard; Tocainidum [INN-Latin] . . . 
                 C11H16N2O 
               
               
                 pilocarpine; Isoptocarpine; Pilocarpin . . . 
                 C11H16N2O2 
               
               
                 butalbital; Allylbarbital; Itobarbital . . . 
                 C11H16N2O3 
               
               
                 Dexrazoxane; Zinecard; Cardioxane . . . 
                 C11H16N4O4 
               
               
                 Bretylium; Bretylium tolsylate; Bretylum . . . 
                 C11H17BrN+ 
               
               
                 MEPHENTERMINE; Mephenterdrine; Mefenterdrin . . . 
                 C11H17N 
               
               
                 Mexiletine; Mexiletene; Mexiletina . . . 
                 C11H17NO 
               
               
                 isoproterenol; Isoprenaline; Norisodrine . . . 
                 C11H17NO3 
               
               
                 metaproterenol; ORCIPRENALINE; Alupent . . . 
                 C11H17NO3 
               
               
                 methoxamine; Methoxamedrine; Methoxamin . . . 
                 C11H17NO3 
               
               
                 amobarbital; Amylobarbitone; Amytal . . . 
                 C11H18N2O3 
               
               
                 pentobarbital; Pentobarbitone; Nembutal . . . 
                 C11H18N2O3 
               
               
                 mecamylamine; Versamine; Mecamine . . . 
                 C11H21N 
               
               
                 menadione; Vitamin K3; 2-Methyl-1,4-naphthoquinone . . . 
                 C11H8O2 
               
               
                 Sorbinil; Sorbinilo; Sorbinilum . . . 
                 C11H9FN2O3 
               
               
                 nilutamide; Anandron; Nilandron . . . 
                 C12H10F3N3O4 
               
               
                 cinoxacin; Cinobac; Compound 64716 . . . 
                 C12H10N2O5 
               
               
                 furosemide; Frusemide; Lasix . . . 
                 C12H11ClN2O5S 
               
               
                 PELDESINE; Peldesine [USAN]; BCX-34 . . . 
                 C12H11N5O 
               
               
                 triamterene; Dyrenium; Noridil . . . 
                 C12H11N7 
               
               
                 dapsone; Diaphenylsulfone; Sulfona . . . 
                 C12H12N2O2S 
               
               
                 ENOXIMONE; Perfan; Fenoximone . . . 
                 C12H12N2O2S 
               
               
                 nalidixic acid; Nalidixin; Nevigramon . . . 
                 C12H12N2O3 
               
               
                 phenobarbital; Luminal; Phenobarbitol . . . 
                 C12H12N2O3 
               
               
                 DAZOXIBEN; Dazoxiben [INN-Spanish]; Dazoxibene [INN-French] . . . 
                 C12H12N2O3 
               
               
                 pyrimethamine; Daraprim; Ethylpyrimidine . . . 
                 C12H13ClN4 
               
               
                 rasagiline; 136236-51-6; (R)-N-(2-Propynyl)-2,3-dihydroinden-1-amine 
                 C12H13N 
               
               
                 isocarboxazid; Isocarbonazid; Isocarboxazide . . . 
                 C12H13N3O2 
               
               
                 METHSUXIMIDE; Mesuximide; Celontin . . . 
                 C12H13NO2 
               
               
                 MEPHENYTOIN; Methoin; Phenantoin . . . 
                 C12H14N2O2 
               
               
                 primidone; Primaclone; Mysoline . . . 
                 C12H14N2O2 
               
               
                 sulfamethazine; Sulfadimidine; Sulfadimezine . . . 
                 C12H14N4O2S 
               
               
                 sulfacytine; Renoquid; 1-Ethyl-N-sulfanilylcytosine . . . 
                 C12H14N4O3S 
               
               
                 SULFADOXINE; Sulphadoxine; Sulforthomidine . . . 
                 C12H14N4O4S 
               
               
                 clofibrate; Atromid; Atromid-S . . . 
                 C12H15ClO3 
               
               
                 albendazole; Valbazen; Albenza . . . 
                 C12H15N3O2S 
               
               
                 Entecavir; Baraclude; 142217-69-4 . . . 
                 C12H15N5O3 
               
               
                 fenfluramine; Adifax; d-Fenfluramine . . . 
                 C12H16F3N 
               
               
                 Hexobarbital; Hexobarbitone; Evipal . . . 
                 C12H16N2O3 
               
               
                 imipenem; Imipemide; Tienamycin . . . 
                 C12H17N3O4S 
               
               
                 thiamine; thiamin; Aneurin . . . 
                 C12H17N4OS+ 
               
               
                 CICLOPIROX; Loprox; Penlac . . . 
                 C12H17NO2 
               
               
                 clenbuterol; Planipart; Clenbuterolum . . . 
                 C12H18Cl2N2O 
               
               
                 thiamylal; Thioseconal; Surital . . . 
                 C12H18N2O2S 
               
               
                 tolbutamide; Orinase; Diabetol . . . 
                 C12H18N2O3S 
               
               
                 midodrine; Midodrin; Midodrinum [INN-Latin] . . . 
                 C12H18N2O4 
               
               
                 propofol; 2,6-DIISOPROPYLPHENOL; Diprivan . . . 
                 C12H18O 
               
               
                 procarbazine; Natulan; Ibenzmethyzin . . . 
                 C12H19N3O 
               
               
                 terbutaline; Bricanyl; Brican . . . 
                 C12H19NO3 
               
               
                 PIRBUTEROL; pyrbuterol; Maxair . . . 
                 C12H20N2O3 
               
               
                 sotalol; beta-Cardone; Sotalolum . . . 
                 C12H20N2O3S 
               
               
                 zanamivir; Relenza; Zanamavir . . . 
                 C12H20N4O7 
               
               
                 memantine; Memantinum [INN-Latin]; Memantina [INN-Spanish] . . . 
                 C12H21N 
               
               
                 rimantadine; Remantadine; Riamantadine . . . 
                 C12H21N 
               
               
                 Brinzolamide; Azopt; Birnzolamide . . . 
                 C12H21N3O5S3 
               
               
                 nizatidine; Axid; Acinon . . . 
                 C12H21N5O2S2 
               
               
                 topiramate; Topamax; Epitomax . . . 
                 C12H21NO8S 
               
               
                 bithionol; Lorothidol; Bithin . . . 
                 C12H6Cl4O2S 
               
               
                 triclosan; 5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL; 3380-34-5 
                 C12H7Cl3O2 
               
               
                 leflunomide; Arava; 75706-12-6 . . . 
                 C12H9F3N2O2 
               
               
                 milrinone; Primacor; 78415-72-2 . . . 
                 C12H9N3O 
               
               
                 NITAZOXANIDE; Alinia; 55981-09-4 . . . 
                 C12H9N3O5S 
               
               
                 thalidomide; Thalomid; Distaval . . . 
                 C13H10N2O4 
               
               
                 Proflavin; Proflavine; 3,6-ACRIDINEDIAMINE . . . 
                 C13H11N3 
               
               
                 tenoxicam; Mobiflex; Tilcotil . . . 
                 C13H11N3O4S2 
               
               
                 ETHACRYNIC acid; Edecrin; Hydromedin . . . 
                 C13H12Cl2O4 
               
               
                 fluconazole; Diflucan; Triflucan . . . 
                 C13H12F2N6O 
               
               
                 nimesulide; Mesulid; Nimed . . . 
                 C13H12N2O5S 
               
               
                 Monobenzone; 4-Benzyloxyphenol; 4-(Benzyloxy)phenol . . . 
                 C13H12O2 
               
               
                 Lenalidomide; Revlimid; Revimid . . . 
                 C13H13N3O3 
               
               
                 Cephacetrile; Cefacetrile; Cefacetril . . . 
                 C13H13N3O6S 
               
               
                 ceftizoxime; Ceftizoximum; Ceftizoxima . . . 
                 C13H13N5O5S2 
               
               
                 Tacrine; Tetrahydroaminoacridine; Romotal . . . 
                 C13H14N2 
               
               
                 Mephobarbital; Mebaral; Mephobarbitone . . . 
                 C13H14N2O3 
               
               
                 Clorgiline; CLORGYLINE; Chlorgyline . . . 
                 C13H15Cl2NO 
               
               
                 glutethimide; Doriden; Noxiron . . . 
                 C13H15NO2 
               
               
                 ketamine; Ketaject; Ketanest . . . 
                 C13H16ClNO 
               
               
                 Medetomidine; Medetomidinum [Latin]; Medetomidina [Spanish] . . . 
                 C13H16N2 
               
               
                 aminoglutethimide; Cytadren; Orimeten . . . 
                 C13H16N2O2 
               
               
                 Veliparib; ABT-888; 912444-00-9 . . . 
                 C13H16N4O 
               
               
                 moclobemide; Aurorix; Manerix . . . 
                 C13H17ClN2O2 
               
               
                 selegiline; Emsam; Jumex . . . 
                 C13H17N 
               
               
                 Amfebutamone; bupropion; Amfebutamon . . . 
                 C13H18ClNO 
               
               
                 Heptabarbital; Heptabarb; Heptabarbitone . . . 
                 C13H18N2O3 
               
               
                 pentoxifylline; Trental; Oxpentifylline . . . 
                 C13H18N4O3 
               
               
                 ibuprofen; Motrin; Brufen . . . 
                 C13H18O2 
               
               
                 CHLOROPROCAINE; Chloroprocain; Halestyn . . . 
                 C13H19ClN2O2 
               
               
                 DIETHYLPROPION; Amfepramone; Diethylpropione . . . 
                 C13H19NO 
               
               
                 probenecid; Benemid; Probecid . . . 
                 C13H19NO4S 
               
               
                 prilocaine; Propitocaine; Citanest . . . 
                 C13H20N2O 
               
               
                 procaine; Novocaine; Duracaine . . . 
                 C13H20N2O2 
               
               
                 valacyclovir; Valaciclovir; Valtrex . . . 
                 C13H20N6O4 
               
               
                 PROCAINAMIDE; Novocainamide; Biocoryl . . . 
                 C13H21N3O 
               
               
                 Salbutamol; albuterol; Proventil . . . 
                 C13H21NO3 
               
               
                 isoetharine; Isoetarin; Isoetarine . . . 
                 C13H21NO3 
               
               
                 timolol; Betimol; Istalol . . . 
                 C13H24N4O3S 
               
               
                 hexachlorophene; Hexachlorofen; Hexachlorophen . . . 
                 C13H6Cl6O2 
               
               
                 diflunisal; Dolobid; Dolobis . . . 
                 C13H8F2O3 
               
               
                 niflumic acid; Nifluril; Landruma . . . 
                 C13H9F3N2O2 
               
               
                 bromazepam; Compedium; Lectopam . . . 
                 C14H10BrN3O 
               
               
                 mitotane; Lysodren; Chlodithane . . . 
                 C14H10Cl4 
               
               
                 Nitisinone; Orfadin; 104206-65-7 . . . 
                 C14H10F3NO5 
               
               
                 dantrolene; Dantroleno; Dantrolenum [INN-Latin] . . . 
                 C14H10N4O5 
               
               
                 Salsalate; sasapyrine; Disalcid . . . 
                 C14H10O5 
               
               
                 diclofenac; Diclofenac acid; dichlofenac . . . 
                 C14H11Cl2NO2 
               
               
                 meclofenamate; meclofenamic acid; Arquel . . . 
                 C14H11Cl2NO2 
               
               
                 chlorthalidone; Chlortalidone; Phthalamudine . . . 
                 C14H11ClN2O4S 
               
               
                 Tolcapone; Tasmar; 134308-13-7 . . . 
                 C14H11NO5 
               
               
                 LEVOSIMENDAN; Simdax; Levosimedan . . . 
                 C14H12N6O 
               
               
                 BENZYL BENZOATE; Ascabiol; Novoscabin . . . 
                 C14H12O2 
               
               
                 oxybenzone; 2-HYDROXY-4-METHOXYBENZOPHENONE; 131-57-7 . . . 
                 C14H12O3 
               
               
                 suprofen; Profenal; Maldocil . . . 
                 C14H12O3S 
               
               
                 tiaprofenic acid; Tiaprofensaeure; Surgam . . . 
                 C14H12O3S 
               
               
                 meloxicam; Mobic; Movalis . . . 
                 C14H13N3O4S2 
               
               
                 cefdinir; Omnicef; CFDN . . . 
                 C14H13N5O5S2 
               
               
                 ticlopidine; Ticlid; Ticlopidina . . . 
                 C14H14ClNS 
               
               
                 naphazoline; Naphthizine; Clearine . . . 
                 C14H14N2 
               
               
                 metyrapone; Metopirone; Metopiron . . . 
                 C14H14N2O 
               
               
                 DL-Naproxen; Floginax; Naprius . . . 
                 C14H14O3 
               
               
                 NAPROXEN; 22204-53-1; Naproxene . . . 
                 C14H14O3 
               
               
                 ENTACAPONE; Comtan; Comtess . . . 
                 C14H15N3O5 
               
               
                 Irosustat; 667-Coumate; 667 coumate . . . 
                 C14H15NO5S 
               
               
                 cyclothiazide; Anhydron; Aquirel . . . 
                 C14H16ClN3O4S2 
               
               
                 IMIQUIMOD; Aldara; 99011-02-6 . . . 
                 C14H16N4 
               
               
                 Opaviraline; GW420867X; Isopropyl (2s)-2-Ethyl-7-Fluoro-3-Oxo-3,4- 
                 C14H17FN2O3 
               
               
                 Dihydroquinoxaline-1(2h)-Carboxylate . . . 
               
               
                 Frovatriptan; Frova; Miguard . . . 
                 C14H17N3O 
               
               
                 Fasudil; AT 877; Fasudil [INN] . . . 
                 C14H17N3O2S 
               
               
                 ibudilast; Ketas; Ke Tas . . . 
                 C14H18N2O 
               
               
                 METHOHEXITAL; Methohexitone; Brevital . . . 
                 C14H18N2O3 
               
               
                 trimethoprim; Proloprim; Trimpex . . . 
                 C14H18N4O3 
               
               
                 chlorambucil; Leukeran; Ambochlorin . . . 
                 C14H19Cl2NO2 
               
               
                 famciclovir; Famvir; 104227-87-4 . . . 
                 C14H19N5O4 
               
               
                 methylphenidate; Daytrana; Methylphenidan . . . 
                 C14H19NO2 
               
               
                 pindolol; Visken; Prinodolol . . . 
                 C14H20N2O2 
               
               
                 Vorinostat; SAHA; Zolinza . . . 
                 C14H20N2O3 
               
               
                 sumatriptan; Imitrex; Sumatran . . . 
                 C14H21N3O2S 
               
               
                 oxamniquine; Vansil; Mansil . . . 
                 C14H21N3O3 
               
               
                 tolazamide; Tolinase; Norglycin . . . 
                 C14H21N3O3S 
               
               
                 metoclopramide; Primperan; Reliveran . . . 
                 C14H22ClN3O2 
               
               
                 lidocaine; Xylocaine; Lignocaine . . . 
                 C14H22N2O 
               
               
                 rivastigmine; ENA 713 free base; 123441-03-2 . . . 
                 C14H22N2O2 
               
               
                 atenolol; Tenormin; Prenormine . . . 
                 C14H22N2O3 
               
               
                 Valganciclovir; Cymeval; L-Valine, ester with ganciclovir . . . 
                 C14H22N6O5 
               
               
                 Spectinomycin; actinospectacin; Trobicin . . . 
                 C14H24N2O7 
               
               
                 ellagic acid; Benzoaric acid; Lagistase . . . 
                 C14H6O8 
               
               
                 efavirenz; Sustiva; Stocrin . . . 
                 C14H9ClF3NO2 
               
               
                 lorazepam; Ativan; Temesta . . . 
                 C15H10Cl2N2O2 
               
               
                 clonazepam; Rivotril; Antelepsin . . . 
                 C15H10ClN3O3 
               
               
                 phenindione; 2-Phenyl-1,3-indandione; Phenylindanedione . . . 
                 C15H10O2 
               
               
                 oxazepam; Adumbran; Serax . . . 
                 C15H11ClN2O2 
               
               
                 L-thyroxine; levothyroxine; synthroid . . . 
                 C15H11I4NO4 
               
               
                 nitrazepam; Benzalin; Mogadon . . . 
                 C15H11N3O3 
               
               
                 Bromfenac; Duract; Xibrom . . . 
                 C15H12BrNO3 
               
               
                 carprofen; Rimadyl; Imadyl . . . 
                 C15H12ClNO2 
               
               
                 liothyronine; triiodothyronine; Tresitope . . . 
                 C15H12I3NO4 
               
               
                 carbamazepine; Tegretol; Carbamazepen . . . 
                 C15H12N2O 
               
               
                 phenytoin; 5,5-DIPHENYLHYDANTOIN; Diphenylhydantoin . . . 
                 C15H12N2O2 
               
               
                 OXCARBAZEPINE; Trileptal; Oxcarbamazepine . . . 
                 C15H12N2O2 
               
               
                 Lumiracoxib; Prexige; COX 189 . . . 
                 C15H13ClFNO2 
               
               
                 flurbiprofen; Ansaid; Froben . . . 
                 C15H13FO2 
               
               
                 piroxicam; Feldene; 36322-90-4 . . . 
                 C15H13N3O4S 
               
               
                 ketorolac; Ketoralac; Ketorolacum [Latin] . . . 
                 C15H13NO3 
               
               
                 benzthiazide; Benzothiazide; Aquatag . . . 
                 C15H14ClN3O4S3 
               
               
                 BENDROFLUMETHIAZIDE; Bendrofluazide; Naturetin . . . 
                 C15H14F3N3O4S2 
               
               
                 flumazenil; Flumazepil; Romazicon . . . 
                 C15H14FN3O3 
               
               
                 nevirapine; Viramune; 129618-40-2 . . . 
                 C15H14N4O 
               
               
                 ceftibuten; Cedax; Ceftibuteno . . . 
                 C15H14N4O6S2 
               
               
                 fenoprofen; 2-(3-Phenoxyphenyl)propanoic acid; Nalfon . . . 
                 C15H14O3 
               
               
                 mefenamic acid; Ponstel; Parkemed . . . 
                 C15H15NO2 
               
               
                 tolmetin; Tolectin; Tolmetine . . . 
                 C15H15NO3 
               
               
                 nabumetone; Relafen; Listran . . . 
                 C15H16O2 
               
               
                 enoxacin; Penetrex; Comprecin . . . 
                 C15H17FN4O3 
               
               
                 CEFPODOXIME; Cefpodoxima; Cefpodoximum . . . 
                 C15H17N5O6S2 
               
               
                 cefmetazole; Cefmetazolum; Cefmetazolo . . . 
                 C15H17N7O5S3 
               
               
                 mitomycin C; Mutamycin; Ametycine . . . 
                 C15H18N4O5 
               
               
                 rizatriptan; Risatriptan; MK 462 free base . . . 
                 C15H19N5 
               
               
                 acetohexamide; Dymelor; Gamadiabet . . . 
                 C15H20N2O4S 
               
               
                 fluvoxamine; Floxyfral; Dumirox . . . 
                 C15H21F3N2O2 
               
               
                 Fencamfamin; Euvitol; Reactivan . . . 
                 C15H21N 
               
               
                 PRIMAQUINE; Neo-Quipenyl; Primachin . . . 
                 C15H21N3O 
               
               
                 physostigmine; Eserine; Antilirium . . . 
                 C15H21N3O2 
               
               
                 gliclazide; Diamicron; Glimicron . . . 
                 C15H21N3O3S 
               
               
                 meperidine; Pethidine; Demerol . . . 
                 C15H21NO2 
               
               
                 CAPECITABINE; Xeloda; 154361-50-9 . . . 
                 C15H22FN3O6 
               
               
                 mepivacaine; Carbocaine; Scandicain . . . 
                 C15H22N2O 
               
               
                 Milnacipran; Midalcipran; Toledomin . . . 
                 C15H22N2O 
               
               
                 gemfibrozil; Lopid; Decrelip . . . 
                 C15H22O3 
               
               
                 Mecillinam; Coactin; AMDINOCILLIN . . . 
                 C15H23N3O3S 
               
               
                 ciclacillin; CYCLACILLIN; Bastcillin . . . 
                 C15H23N3O4S 
               
               
                 sulpiride; Aiglonyl; Sulpirid . . . 
                 C15H23N3O4S 
               
               
                 alprenolol; Alfeprol; Yobir . . . 
                 C15H23NO2 
               
               
                 oxprenolol; Coretai; dl-Oxprenolol . . . 
                 C15H23NO3 
               
               
                 Lisdexamfetamine; NRP104; 608137-32-2 . . . 
                 C15H25N3O 
               
               
                 metoprolol; Lopressor; Seloken . . . 
                 C15H25NO3 
               
               
                 Marimastat; Marimastat [USAN]; BB-2516 . . . 
                 C15H29N3O5 
               
               
                 fludiazepam; Erispan; Fludiazepamum [INN-Latin] . . . 
                 C16H12ClFN2O 
               
               
                 Benoxaprofen; Oraflex; Inflamid . . . 
                 C16H12ClNO3 
               
               
                 flunitrazepam; Rohypnol; Narcozep . . . 
                 C16H12FN3O3 
               
               
                 anisindione; Miradon; Anisin indandione . . . 
                 C16H12O3 
               
               
                 tioconazole; Vagistat-1; Trosyl . . . 
                 C16H13Cl3N2OS 
               
               
                 diazepam; Valium; Ansiolisina . . . 
                 C16H13ClN2O 
               
               
                 mazindol; Mazanor; Sanorex . . . 
                 C16H13ClN2O 
               
               
                 Clobazam; Chlorepin; Urbanyl . . . 
                 C16H13ClN2O2 
               
               
                 temazepam; Crisonar; Restoril . . . 
                 C16H13ClN2O2 
               
               
                 mebendazole; Vermox; Telmin . . . 
                 C16H13N3O3 
               
               
                 chlordiazepoxide; Chlozepid; Elenium . . . 
                 C16H14ClN3O 
               
               
                 lansoprazole; Bamalite; Monolitum . . . 
                 C16H14F3N3O2S 
               
               
                 Voriconazole; Vfend; 137234-62-9 . . . 
                 C16H14F3N5O 
               
               
                 TOLRESTAT; Alredase; Tolrestatum . . . 
                 C16H14F3NO3S 
               
               
                 amlexanox; Aphthasol; Amoxanox . . . 
                 C16H14N2O4 
               
               
                 ketoprofen; Orudis; Profenid . . . 
                 C16H14O3 
               
               
                 clotiazepam; Trecalmo; Rizen . . . 
                 C16H15ClN2OS 
               
               
                 pantoprazole; Protonix; Pantozol . . . 
                 C16H15F2N3O4S 
               
               
                 Sitagliptin; Xelevia; Januvia . . . 
                 C16H15F6N5O 
               
               
                 Fosphenytoin; Prodilantin; Fosfenitoina [INN-Spanish] . . . 
                 C16H15N2O6P 
               
               
                 epinastine; Epinastinum [Latin]; Epinastina [Spanish] . . . 
                 C16H15N3 
               
               
                 Tanaproget; 1zuc; NSP-989 . . . 
                 C16H15N3OS 
               
               
                 indapamide; Tertensif; Arifon . . . 
                 C16H16ClN3O3S 
               
               
                 metolazone; Zaroxolyn; Mykrox . . . 
                 C16H16ClN3O3S 
               
               
                 clopidogrel; Plavix; (S)-Clopidogrel . . . 
                 C16H16ClNO2S 
               
               
                 fenoldopam; Corlopam; Fenoldopamum [Latin] . . . 
                 C16H16ClNO3 
               
               
                 Febuxostat; 144060-53-7; Uloric . . . 
                 C16H16N2O3S 
               
               
                 cephalothin; Cefalotin; Cephalothinum . . . 
                 C16H16N2O6S2 
               
               
                 Zimeldine; Zimelidine; cis-Zimelidine . . . 
                 C16H17BrN2 
               
               
                 cephalexin; Cefalexin; Cephacillin . . . 
                 C16H17N3O4S 
               
               
                 cefoxitin; Mefoxitin; Mefoxin . . . 
                 C16H17N3O7S2 
               
               
                 norfloxacin; Noroxin; Chibroxin . . . 
                 C16H18FN3O3 
               
               
                 Nomifensine; nomifensin; Linamiphen . . . 
                 C16H18N2 
               
               
                 penicillin g; Benzylpenicillin; Pencillin G . . . 
                 C16H18N2O4S 
               
               
                 penicillin v; Phenomycilline; Beromycin . . . 
                 C16H18N2O5S 
               
               
                 BROMPHENIRAMINE; Dimetane; Bromfeniramina . . . 
                 C16H19BrN2 
               
               
                 chlorpheniramine; Chlorphenamine; Chlor-trimeton . . . 
                 C16H19ClN2 
               
               
                 carbinoxamine; Paracarbinoxamine; Allergefon . . . 
                 C16H19ClN2O 
               
               
                 cephradine; Cefradine; Anspor . . . 
                 C16H19N3O4S 
               
               
                 ampicillin; Omnipen; Ampicillin acid . . . 
                 C16H19N3O4S 
               
               
                 amoxicillin; Amoxycillin; Amoxicilline . . . 
                 C16H19N3O5S 
               
               
                 Tivirapine; CHEMBL58711; NSC636661 . . . 
                 C16H20ClN3S 
               
               
                 linezolid; Zyvox; Zyvoxid . . . 
                 C16H20FN3O4 
               
               
                 pheniramine; Prophenpyridamine; Tripoton . . . 
                 C16H20N2 
               
               
                 TORSEMIDE; Torasemide; Demadex . . . 
                 C16H20N4O3S 
               
               
                 Tasocitinib; Tofacitinib; 477600-75-2 . . . 
                 C16H20N6O 
               
               
                 tripelennamine; Pyribenzamine; Tripelennamin . . . 
                 C16H21N3 
               
               
                 Ramelteon; Rozerem; TAK-375 . . . 
                 C16H21NO2 
               
               
                 propranolol; Propanolol; beta-Propranolol . . . 
                 C16H21NO2 
               
               
                 Remoxipride; Romoxipride; Remoxipridum [INN-Latin] . . . 
                 C16H23BrN2O3 
               
               
                 HEXYLCAINE; Hexylcainum [INN-Latin]; Hexilcaina [INN-Spanish] . . . 
                 C16H23NO2 
               
               
                 oxymetazoline; Oxymethazoline; Oxylazine . . . 
                 C16H24N2O 
               
               
                 ropinirole; ReQuip; ropinirol . . . 
                 C16H24N2O 
               
               
                 MOLINDONE; Moban; (+−)-Molindone . . . 
                 C16H24N2O2 
               
               
                 CARTEOLOL; Carteololum; Carteololum [INN-Latin] . . . 
                 C16H24N2O3 
               
               
                 Desvenlafaxine; O-Desmethylvenlafaxine; 93413-62-8 . . . 
                 C16H25NO2 
               
               
                 Tramadol; Ultram; Ralivia flashtab . . . 
                 C16H25NO2 
               
               
                 ESMOLOL; (+−)-Esmolol; Esmolol [INN:BAN] . . . 
                 C16H25NO4 
               
               
                 proparacaine; Ophthaine; Proxymetacaine . . . 
                 C16H26N2O3 
               
               
                 Cilastatin; Cilastatina; Cilastatine . . . 
                 C16H26N2O5S 
               
               
                 oseltamivir; Tamiflu; Tamvir . . . 
                 C16H28N2O4 
               
               
                 palmitic acid; Hexadecanoic acid; Cetylic acid . . . 
                 C16H32O2 
               
               
                 Zenarestat; Zenarestatum; Zenarestatum [INN-Latin] . . . 
                 C17H11BrClFN2O4 
               
               
                 quazepam; Doral; Dormalin . . . 
                 C17H11ClF4N2S 
               
               
                 letrozole; Femara; Letrozol . . . 
                 C17H11N5 
               
               
                 triazolam; Halcion; Clorazolam . . . 
                 C17H12Cl2N4 
               
               
                 Halazepam; Paxipam; Pacinone . . . 
                 C17H12ClF3N2O 
               
               
                 alprazolam; Xanax; Cassadan . . . 
                 C17H13ClN4 
               
               
                 celecoxib; Celebrex; Celebra . . . 
                 C17H14F3N3O2S 
               
               
                 ROSOXACIN; Acrosoxacin; Eradacil . . . 
                 C17H14N2O3 
               
               
                 rofecoxib; Vioxx; Ceoxx . . . 
                 C17H14O4S 
               
               
                 zaleplon; Sonata; 151319-34-5 . . . 
                 C17H15N5O 
               
               
                 amoxapine; Asendin; Demolox . . . 
                 C17H16ClN3O 
               
               
                 Lariam; mefloquine; Mefloquinone . . . 
                 C17H16F6N2O 
               
               
                 sertraline; Lustral; Zoloft . . . 
                 C17H17Cl2N 
               
               
                 zopiclone; Imovane; Amoban . . . 
                 C17H17ClN6O3 
               
               
                 cephapirin; Cefapirin; Cephapirine . . . 
                 C17H17N3O6S2 
               
               
                 fluoxetine; Pulvules; Portal . . . 
                 C17H18F3NO 
               
               
                 ciprofloxacin; Ciprobay; Cipro . . . 
                 C17H18FN3O3 
               
               
                 piretanide; Tauliz; Arelix (TN) . . . 
                 C17H18N2O5S 
               
               
                 nifedipine; Procardia; Adalat . . . 
                 C17H18N2O6 
               
               
                 carbenicillin; Pyopen; Carboxybenzylpenicillin . . . 
                 C17H18N2O6S 
               
               
                 alosetron; Lotronex; Alosetron HCl . . . 
                 C17H18N4O 
               
               
                 chlorpromazine; Largactil; Thorazine . . . 
                 C17H19ClN2S 
               
               
                 lomefloxacin; Lomefloxacine; Lomefloxacino . . . 
                 C17H19F2N3O3 
               
               
                 antazoline; Antasten; Phenazoline . . . 
                 C17H19N3 
               
               
                 mirtazapine; Remeron; Remergil . . . 
                 C17H19N3 
               
               
                 phentolamine; Regitine; Rogitine . . . 
                 C17H19N3O 
               
               
                 omeprazole; Prilosec; Antra . . . 
                 C17H19N3O3S 
               
               
                 anastrozole; Arimidex; anastrazole . . . 
                 C17H19N5 
               
               
                 Piritrexim; Piritrexime [French]; Piritreximum [Latin] . . . 
                 C17H19N5O2 
               
               
                 hydromorphone; Dihydromorphinone; Dimorphone . . . 
                 C17H19NO3 
               
               
                 oxymorphone; Numorphan; Oximorphonum . . . 
                 C17H19NO4 
               
               
                 Bromdiphenhydramine; bromodiphenhydramine; Bromazine . . . 
                 C17H20BrNO 
               
               
                 CHLOPHEDIANOL; Chlofedanol; Dencyl . . . 
                 C17H20ClNO 
               
               
                 flecainide; Flecaine; Tambocor . . . 
                 C17H20F6N2O3 
               
               
                 Pefloxacin; Pefloxacine; Pefloxacinum . . . 
                 C17H20FN3O3 
               
               
                 tropicamide; Tropicacyl; Mydriacyl . . . 
                 C17H20N2O2 
               
               
                 bumetanide; Bumex; Fordiuran . . . 
                 C17H20N2O5S 
               
               
                 methicillin; Meticillin; Methicillinum . . . 
                 C17H20N2O6S 
               
               
                 promazine; Protactyl; Sinophenin . . . 
                 C17H20N2S 
               
               
                 promethazine; Proazamine; Diphergan . . . 
                 C17H20N2S 
               
               
                 olanzapine; Zyprexa; Zyprexa Zydis . . . 
                 C17H20N4S 
               
               
                 mycophenolic acid; Melbex; Mycophenolate . . . 
                 C17H20O6 
               
               
                 diphenhydramine; Benadryl; Alledryl . . . 
                 C17H21NO 
               
               
                 Atomoxetine; Tomoxetine; Tomoxetinum . . . 
                 C17H21NO 
               
               
                 etodolac; Etodolic acid; Lodine . . . 
                 C17H21NO3 
               
               
                 ritodrine; Yutopar; Ritodrina [INN-Spanish] . . . 
                 C17H21NO3 
               
               
                 fenoterol; Phenoterol; Berotec . . . 
                 C17H21NO4 
               
               
                 doxylamine; Dossilamina [DCIT]; Doxylaminum [INN-Latin] . . . 
                 C17H22N2O 
               
               
                 Emivirine; Coactinon; MKC-442 . . . 
                 C17H22N2O3 
               
               
                 minaprine; Cantor; Brantur . . . 
                 C17H22N4O 
               
               
                 PF-734200; PF-00734200; 869490-23-3 . . . 
                 C17H24F2N6O 
               
               
                 PHENCYCLIDINE; Angel dust; 1-(1-Phenylcyclohexyl)piperidine . . . 
                 C17H25N 
               
               
                 Almotriptan; Axert; Almogran . . . 
                 C17H25N3O2S 
               
               
                 naratriptan; Naramig; Amerge . . . 
                 C17H25N3O2S 
               
               
                 cyclopentolate; Cyclogyl; Ciclopentolato . . . 
                 C17H25NO3 
               
               
                 LEVOBUNOLOL; Betagan; Akbeta . . . 
                 C17H25NO3 
               
               
                 sibutramine; Reductil; Medaria . . . 
                 C17H26ClN 
               
               
                 emedastine; Emadine; Emedastinum [INN-Latin] . . . 
                 C17H26N4O 
               
               
                 amisulpride; Solian; Aminosultopride . . . 
                 C17H27N3O4S 
               
               
                 venlafaxine; Elafax; Venlafaxina . . . 
                 C17H27NO2 
               
               
                 Metipranolol; Trimepranol; Disorat . . . 
                 C17H27NO4 
               
               
                 nadolol; Corgard; Solgol . . . 
                 C17H27NO4 
               
               
                 Oxybuprocaine; Benoxinate; Oxybucaine . . . 
                 C17H28N2O3 
               
               
                 Lidorestat; IDD-676; IDD-000676-01 . . . 
                 C18H11F3N2O2S 
               
               
                 midazolam; Dormicum; Versed . . . 
                 C18H13ClFN3 
               
               
                 Cinolazepam; Gerodorm; Cinolazepamum . . . 
                 C18H13ClFN3O2 
               
               
                 miconazole; Monistat; Daktarin IV . . . 
                 C18H14Cl4N2O 
               
               
                 (R)-Bicalutamide; R-BICALUTAMIDE; CHEBL3090 . . . 
                 C18H14F4N2O4S 
               
               
                 econazole; Ecostatin; Pevaryl . . . 
                 C18H15Cl3N2O 
               
               
                 Etoricoxib; Arcoxia; Tauxib . . . 
                 C18H15ClN2O2S 
               
               
                 Sitaxsentan; Sitaxentan; Thelin . . . 
                 C18H15ClN2O6S2 
               
               
                 oxaprozin; Daypro; Deflam . . . 
                 C18H15NO3 
               
               
                 PHENPROCOUMON; Phenprocoumarol; Liquamar . . . 
                 C18H16O3 
               
               
                 tranilast; Rizaben; Tranilastum . . . 
                 C18H17NO5 
               
               
                 loxapine; Cloxazepine; Dibenzoazepine . . . 
                 C18H18ClN3O 
               
               
                 cefamandole; Cefadole; Cefamandolum . . . 
                 C18H18N6O5S2 
               
               
                 ceftriaxone; Biotrakson; Cefatriaxone . . . 
                 C18H18N8O7S3 
               
               
                 dienestrol; Dehydrostilbestrol; Dienoestrol . . . 
                 C18H18O2 
               
               
                 felodipine; Plendil; Perfudal . . . 
                 C18H19Cl2NO4 
               
               
                 clozapine; Leponex; Fazaclo . . . 
                 C18H19ClN4 
               
               
                 triflupromazine; Fluopromazine; Siquil . . . 
                 C18H19F3N2S 
               
               
                 ondansetron; Zofran; Zophren . . . 
                 C18H19N3O 
               
               
                 rosiglitazone; Avandia; Rosiglizole . . . 
                 C18H19N3O3S 
               
               
                 cefprozil; Cefprozil anhydrous; Brisoral . . . 
                 C18H19N3O5S 
               
               
                 Cefaloglycin; Cephaloglycine; CEPHALOGLYCIN . . . 
                 C18H19N3O6S 
               
               
                 duloxetine; Cymbalta; Yentreve . . . 
                 C18H19NOS 
               
               
                 LEVOFLOXACIN; Levaquin; Quixin . . . 
                 C18H20FN3O4 
               
               
                 mianserin; Mianserine; Mianserina . . . 
                 C18H20N2 
               
               
                 nitrendipine; Baypress; Bayotensin . . . 
                 C18H20N2O6 
               
               
                 METHDILAZINE; Tacaryl; Methodilazine . . . 
                 C18H20N2S 
               
               
                 diethylstilbestrol; Stilbestrol; Distilbene . . . 
                 C18H20O2 
               
               
                 rabeprazole; Rebeprazole sodium; 117976-89-3 . . . 
                 C18H21N3O3S 
               
               
                 codeine; Methylmorphine; Codicept . . . 
                 C18H21NO3 
               
               
                 HYDROCODONE; Dihydrocodeinone; Hydrocodon . . . 
                 C18H21NO3 
               
               
                 oxycodone; Dihydrone; Dihydroxycodeinone . . . 
                 C18H21NO4 
               
               
                 phenoxybenzamine; Dibenyline; Dibenzyran . . . 
                 C18H22ClNO 
               
               
                 desipramine; Norimipramine; Desmethylimipramine . . . 
                 C18H22N2 
               
               
                 CYCLIZINE; Marezine; Nautazine . . . 
                 C18H22N2 
               
               
                 trimeprazine; Methylpromazine; Alimemazine . . . 
                 C18H22N2S 
               
               
                 estrone; folliculin; Theelin . . . 
                 C18H22O2 
               
               
                 cefotiam; Cefotiamum; Cefotiamum [INN-Latin] . . . 
                 C18H23N9O4S3 
               
               
                 orphenadrine; Disipal; o-Methyldiphenhydramine . . . 
                 C18H23NO 
               
               
                 dobutamine; racemic-Dobutamine; Dobutrex . . . 
                 C18H23NO3 
               
               
                 Genesa; ARBUTAMINE; Arbutaminum . . . 
                 C18H23NO4 
               
               
                 Kytril; Granisetron base; Granisetronum [INN-Latin] . . . 
                 C18H24N4O 
               
               
                 estradiol; beta-Estradiol; 17beta-Estradiol . . . 
                 C18H24O2 
               
               
                 estriol; Oestriol; Estratriol . . . 
                 C18H24O3 
               
               
                 Saxagliptin; Onglyza; BMS-477118 . . . 
                 C18H25N3O2 
               
               
                 d-Methorphan; dextromethorphan; Delsym . . . 
                 C18H25NO 
               
               
                 chloroquine; Aralen; Artrichin . . . 
                 C18H26ClN3 
               
               
                 hydroxychloroquine; Oxichlorochinum; Oxychlorochin . . . 
                 C18H26ClN3O 
               
               
                 dyclonine; Dyclocaine; Dyclocainum . . . 
                 C18H27NO2 
               
               
                 bupivacaine; Marcaine; Sensorcaine . . . 
                 C18H28N2O 
               
               
                 Levobupivacaine; L(−)-Bupivacaine; (S)-bupivacaine . . . 
                 C18H28N2O 
               
               
                 acebutolol; Acetobutolol; Neptal . . . 
                 C18H28N2O4 
               
               
                 Bambuterol; Bambec; Bambuterolum . . . 
                 C18H29N3O5 
               
               
                 penbutolol; Betapressin; Levatol . . . 
                 C18H29NO2 
               
               
                 betaxolol; Betoptic; Betaxololum . . . 
                 C18H29NO3 
               
               
                 BISOPROLOL; Concor; Zebeta . . . 
                 C18H31NO4 
               
               
                 KANAMYCIN A; kanamycin; Kanamycin Base . . . 
                 C18H36N4O11 
               
               
                 ZOPOLRESTAT; CP-73850; 110703-94-1 . . . 
                 C19H12F3N3O3S 
               
               
                 dicumarol; dicoumarol; Bishydroxycoumarin . . . 
                 C19H12O6 
               
               
                 ACENOCOUMAROL; Acenocoumarin; Nicoumalone . . . 
                 C19H15NO6 
               
               
                 indomethacin; indometacin; Indocin . . . 
                 C19H16ClNO4 
               
               
                 warfarin; Coumafene; Coumadin . . . 
                 C19H16O4 
               
               
                 dicloxacillin; Dicloxacycline; Dynapen . . . 
                 C19H17Cl2N3O5S 
               
               
                 Butoconazole; Butoconazolum; Butoconazol . . . 
                 C19H17Cl3N2S 
               
               
                 FluCloxacillin; FLOXACILLIN; Floxapen . . . 
                 C19H17ClFN3O5S 
               
               
                 prazepam; Demetrin; Lysanxia . . . 
                 C19H17ClN2O 
               
               
                 tolnaftate; Tinactin; Aftate . . . 
                 C19H17NOS 
               
               
                 Cloxacillin; Cloxacilline; Cloxacillinum . . . 
                 C19H18ClN3O5S 
               
               
                 Rivaroxaban; Xarelto; 366789-02-8 . . . 
                 C19H18ClN3O5S 
               
               
                 ADINAZOLAM; Deracyn; Adinazolamum . . . 
                 C19H18ClN5 
               
               
                 Desloratadine; Clarinex; Descarboethoxyloratadine . . . 
                 C19H19ClN2 
               
               
                 Phenindamine; Thephorin; Nolahist . . . 
                 C19H19N 
               
               
                 oxacillin; Oxazocillin; MPI-penicillin . . . 
                 C19H19N3O5S 
               
               
                 nilvadipine; Escor; Nivadil . . . 
                 C19H19N3O6 
               
               
                 folic acid; Folate; Folvite . . . 
                 C19H19N7O6 
               
               
                 ketotifen; Ketotifene; Ketotifene [INN-French] . . . 
                 C19H19NOS 
               
               
                 bezafibrate; Bezalip; Cedur . . . 
                 C19H20ClNO4 
               
               
                 paroxetine; Paxil; Aropax . . . 
                 C19H20FNO3 
               
               
                 phenylbutazone; Butazolidin; Diphenylbutazone . . . 
                 C19H20N2O2 
               
               
                 Pioglitazone; Actos; Pioglitazona . . . 
                 C19H20N2O3S 
               
               
                 nortriptyline; Sensaval; Noritren . . . 
                 C19H21N 
               
               
                 protriptyline; Amimetilina; Protryptyline . . . 
                 C19H21N 
               
               
                 zolpidem; Lorex; Zolpidemum [Latin] . . . 
                 C19H21N3O 
               
               
                 isradipine; Dynacirc; Lomir . . . 
                 C19H21N3O5 
               
               
                 pirenzepine; Pirenzepin; Gastrozepin . . . 
                 C19H21N5O2 
               
               
                 prazosin; Furazosin; Minipress . . . 
                 C19H21N5O4 
               
               
                 naloxone; I-Naloxone; n-Allylnoroxymorphone . . . 
                 C19H21NO4 
               
               
                 trazodone; Beneficat; Trazalon . . . 
                 C19H22ClN5O 
               
               
                 sparfloxacin; Zagam; Cl-978 . . . 
                 C19H22F2N4O3 
               
               
                 Grepafloxacin; Raxar; Grepafloxacin [INN] . . . 
                 C19H22FN3O3 
               
               
                 Gatifloxacin; Tequin; Zymar . . . 
                 C19H22FN3O4 
               
               
                 Actidil; triprolidine; Myidyl . . . 
                 C19H22N2 
               
               
                 Acepromethazine; Aceprometazine; Aceprometazina . . . 
                 C19H22N2OS 
               
               
                 clomipramine; Chlorimipramine; Hydiphen . . . 
                 C19H23ClN2 
               
               
                 Ergometrine; ERGONOVINE; Ergobasine . . . 
                 C19H23N3O2 
               
               
                 hetacillin; Versapen; Hetacillinum . . . 
                 C19H23N3O4S 
               
               
                 trimetrexate; Cl-898; Trimetrexatum [INN-Latin] . . . 
                 C19H23N5O3 
               
               
                 diphenylpyraline; Allergen; Belfene . . . 
                 C19H23NO 
               
               
                 Reboxetine; Esreboxetine; Davedax . . . 
                 C19H23NO3 
               
               
                 imipramine; Imidobenzyle; Melipramine . . . 
                 C19H24N2 
               
               
                 praziquantel; Biltricide; Droncit . . . 
                 C19H24N2O2 
               
               
                 labetalol; Labetolol; Albetol . . . 
                 C19H24N2O3 
               
               
                 formoterol; Oxis; Foradile . . . 
                 C19H24N2O4 
               
               
                 ethopropazine; Parsidol; Profenamine . . . 
                 C19H24N2S 
               
               
                 pentamidine; Pentacarinat; 100-33-4 . . . 
                 C19H24N4O2 
               
               
                 cefepime; Maxipime; Axepim . . . 
                 C19H24N6O5S2 
               
               
                 testolactone; Teslac; Fludestrin . . . 
                 C19H24O3 
               
               
                 Bortezomib; PS-341; 179324-69-7 . . . 
                 C19H25BN4O4 
               
               
                 terazosin; Terazosine; Flumarc . . . 
                 C19H25N5O4 
               
               
                 levallorphan; Naloxiphan; Lorfan . . . 
                 C19H25NO 
               
               
                 pergolide; Permax; Pergolidum [INN-Latin] . . . 
                 C19H26N2S 
               
               
                 Dofetilide; Tikosyn; Dofetilida . . . 
                 C19H27N3O5S2 
               
               
                 Dapiprazole; Dapiprazol; Glamidolo . . . 
                 C19H27N5 
               
               
                 alfuzosin; Alfuzosinum; Alfusosine . . . 
                 C19H27N5O4 
               
               
                 pentazocine; Pentazocaine; Liticon . . . 
                 C19H27NO 
               
               
                 TETRABENAZINE; Nitoman; Rubigen . . . 
                 C19H27NO3 
               
               
                 testosterone; Androderm; Testoderm . . . 
                 C19H28O2 
               
               
                 cycrimine; Pagitane; Cicrimina . . . 
                 C19H29NO 
               
               
                 procyclidine; Tricyclamol; Arpicolin . . . 
                 C19H29NO 
               
               
                 dipivefrin; Dipivefrine; Propine . . . 
                 C19H29NO5 
               
               
                 OXANDROLONE; Oxandrin; Anavar . . . 
                 C19H30O3 
               
               
                 PERINDOPRIL; Coversyl; ACEON . . . 
                 C19H32N2O5 
               
               
                 PERHEXILINE; Perhexilene; 2-(2,2-Dicyclohexylethyl)piperidine . . . 
                 C19H35N 
               
               
                 dicyclomine; Dicycloverin; Dicycloverine . . . 
                 C19H35NO2 
               
               
                 IODIPAMIDE; Adipiodone; Cholografin . . . 
                 C20H14I6N2O6 
               
               
                 Etravirine; Intelence; TMC-125 . . . 
                 C20H15BrN6O 
               
               
                 Sertaconazole; Sertaconazol [Spanish]; Sertaconazolum [Latin] . . . 
                 C20H15Cl3N2OS 
               
               
                 Trovafloxacin; Trovan; TVFX . . . 
                 C20H15F3N4O3 
               
               
                 moxalactam; Latamoxef; Lamoxactam . . . 
                 C20H20N609S 
               
               
                 fenofibrate; Lipanthyl; Antara . . . 
                 C20H21ClO4 
               
               
                 Escitalopram; (S)-Citalopram; S(+)-Citalopram . . . 
                 C20H21FN2O 
               
               
                 Citalopram; Nitalapram; Cipram . . . 
                 C20H21FN2O 
               
               
                 cyclobenzaprine; Flexeril; Proheptatriene . . . 
                 C20H21N 
               
               
                 Alimta; Pemetrexed [INN:BAN]; HSDB 7316 . . . 
                 C20H21N5O6 
               
               
                 CEFORANIDE; Precef; Ceforanido . . . 
                 C20H21N7O6S2 
               
               
                 amodiaquine; Amodiaquin; Camoquine . . . 
                 C20H22ClN3O 
               
               
                 AZATADINE; Optimine; Azatadine maleate . . . 
                 C20H22N2 
               
               
                 methotrexate; Amethopterin; Rheumatrex . . . 
                 C20H22N8O5 
               
               
                 amitriptyline; Damilen; Elavil . . . 
                 C20H23N 
               
               
                 maprotiline; Deprilept; Maprotylina [Polish] . . . 
                 C20H23N 
               
               
                 naltrexone; Celupan; Vivitrex . . . 
                 C20H23NO4 
               
               
                 Methixart; Metixene; METHIXENE . . . 
                 C20H23NS 
               
               
                 prochlorperazine; Compazine; Prochlorperazin . . . 
                 C20H24ClN3S 
               
               
                 DIMETHINDENE; Dimetindene; Forhistal . . . 
                 C20H24N2 
               
               
                 Ricainid; IN DECAIN IDE; Ricainide . . . 
                 C20H24N2O 
               
               
                 nisoldipine; Sular; Nisocor . . . 
                 C20H24N2O6 
               
               
                 LUCANTHONE; Lucanthon; Tixantone . . . 
                 C20H24N2OS 
               
               
                 propiomazine; Phenoctyl; Propionylpromethazine . . . 
                 C20H24N2OS 
               
               
                 ethinyl estradiol; Ethynylestradiol; Ethinyloestradiol . . . 
                 C20H24O2 
               
               
                 EXEMESTANE; Aromasin; Exemestance . . . 
                 C20H24O2 
               
               
                 Sobetirome; GC-1; Q.RX-431 . . . 
                 C20H24O4 
               
               
                 amlodipine; Amlodis; Amlocard . . . 
                 C20H25ClN2O5 
               
               
                 Lysergide; Lysergamid; LYSERGIC acid DIETHYLAMIDE . . . 
                 C20H25N3O 
               
               
                 methylergonovine; Methylergobasin; Methylergometrin . . . 
                 C20H25N3O2 
               
               
                 tiagabine; Tiagabinum [INN-Latin]; Tiagabina [INN-Spanish] . . . 
                 C20H25NO2S2 
               
               
                 Cilomilast; Ariflo; 153259-65-5 . . . 
                 C20H25NO4 
               
               
                 trimipramine; Trimeprimine; Sapilent . . . 
                 C20H26N2 
               
               
                 LISURIDE; Lysuride; lisuride maleate . . . 
                 C20H26N4O 
               
               
                 norethindrone; Norethisterone; Micronor . . . 
                 C20H26O2 
               
               
                 cilostazol; Pletal; Pletaal . . . 
                 C20H27N5O2 
               
               
                 Glisoxepide; Glisoxepid; Glisepin . . . 
                 C20H27N5O5S 
               
               
                 Trilostane; Modrastane; Modrenal . . . 
                 C20H27NO3 
               
               
                 Bevantolol; Bevantololum; Bevantololum [INN-Latin] . . . 
                 C20H27NO4 
               
               
                 oxyphencyclimine; Manir; Oxiphencycliminum . . . 
                 C20H28N2O3 
               
               
                 REMIFENTANIL; Remifentanyl; Ultiva . . . 
                 C20H28N2O5 
               
               
                 TAMSULOSIN; Flomax; 106133-20-4 . . . 
                 C20H28N2O5S 
               
               
                 Ilomastat; Galardin; GM 6001 . . . 
                 C20H28N4O4 
               
               
                 Retinoic acid; tretinoin; Vitamin A acid . . . 
                 C20H28O2 
               
               
                 fluoxymesterone; Fluoxymestrone; Halotestin . . . 
                 C20H29FO3 
               
               
                 dibucaine; Cinchocaine; Nupercainal . . . 
                 C20H29N3O2 
               
               
                 retinol; Vitamin A; all-trans-Retinol . . . 
                 C20H300 
               
               
                 Timnodonic acid; Eicosapentaenoic acid; Icosapent . . . 
                 C20H3002 
               
               
                 trihexyphenidyl; Benzhexol; Triphenidyl . . . 
                 C20H31NO 
               
               
                 ADEFOVIR DIPIVOXIL; Hepsera; Preveon . . . 
                 C20H32N5O8P 
               
               
                 Dinoprostone; Prostaglandin E2; PGE2 . . . 
                 C20H32O5 
               
               
                 dinoprost; prostaglandin F2alpha; amoglandin . . . 
                 C20H34O5 
               
               
                 alprostadil; Prostaglandin El; Caverject . . . 
                 C20H34O5 
               
               
                 Ibutilide; Ibutilidum [INN-Latin]; Corvert . . . 
                 C20H36N2O3S 
               
               
                 Sorafenib; Nexavar; 284461-73-0 . . . 
                 C21H16ClF3N4O3 
               
               
                 Permethrin; Transpermethrin; Elimite . . . 
                 C21H20Cl2O3 
               
               
                 Flavopiridol; Alvocidib; FLAVO . . . 
                 C21H20ClNO5 
               
               
                 Ziprasidone; Geodon; Zeldox . . . 
                 C21H21ClN4OS 
               
               
                 CYPROHEPTADINE; Eiproheptadine; Periactin . . . 
                 C21H21N 
               
               
                 Naftifine; Naftifin; Naftifina . . . 
                 C21H21N 
               
               
                 tazarotene; Tazorac; Zorac . . . 
                 C21H21NO2S 
               
               
                 nafcillin; Naphcillin; Nafcilin-1 . . . 
                 C21H22N2O5S 
               
               
                 Raltitrexed; Tomudex; ZD1694 . . . 
                 C21H22N4O6S 
               
               
                 flurazepam; Dalmane; Dalmadorm . . . 
                 C21H23ClFN3O 
               
               
                 haloperidol; Haldol; Aloperidol . . . 
                 C21H23ClFNO2 
               
               
                 periClazine; PERICYAZINE; ProperiClazine . . . 
                 C21H23N3OS 
               
               
                 Olopatadine; Patanol; Opatanol . . . 
                 C21H23NO3 
               
               
                 trifluoperazine; Trifluperazine; Trifluoroperazine . . . 
                 C21H24F3N3S 
               
               
                 moxifloxaCln; Vigamox; Avelox I.V. . . . 
                 C21H24FN3O4 
               
               
                 cetirizine; Virlix; Cetryn . . . 
                 C21H25ClN2O3 
               
               
                 terbinafine; Lamisil; Lamasil . . . 
                 C21H25N 
               
               
                 quetiapine; Seroquel; 111974-69-7 . . . 
                 C21H25N3O2S 
               
               
                 MEZLOCILLIN; Mezlin; Mezlocilina . . . 
                 C21H25N5O8S2 
               
               
                 perphenazine; Trilafon; Perfenazine . . . 
                 C21H26ClN3OS 
               
               
                 clemastine; Mecloprodin; Meclastin . . . 
                 C21H26ClNO 
               
               
                 nimodipine; Nimotop; Periplum . . . 
                 C21H26N2O7 
               
               
                 mesoridazine; Lidanar; Serentil . . . 
                 C21H26N2OS2 
               
               
                 thioridazine; Mellaril; Melleril . . . 
                 C21H26N2S2 
               
               
                 mestranol; Devocin; Norquen . . . 
                 C21H26O2 
               
               
                 prednisone; Deltasone; Meticorten . . . 
                 C21H26O5 
               
               
                 hydroxyzine; Hychotine; Hydroxine . . . 
                 C21H27ClN2O2 
               
               
                 triamcinolone; Fluoxyprednisolone; Aristocort . . . 
                 C21H27FO6 
               
               
                 bacampicillin; Penglobe; Bacampicilline . . . 
                 C21H27N3O7S 
               
               
                 glipizide; Glucotrol; Glydiazinamide . . . 
                 C21H27N5O4S 
               
               
                 Difenidol; DIPHENIDOL; Vontrol . . . 
                 C21H27NO 
               
               
                 methadone; Adanon; Dolophine . . . 
                 C21H27NO 
               
               
                 propafenone; Rythmol; Propafenona . . . 
                 C21H27NO3 
               
               
                 Levonorgestrel; Mirena; D-Norgestrel . . . 
                 C21H28O2 
               
               
                 dydrogesterone; Isopregnenone; Hydrogesterone . . . 
                 C21H28O2 
               
               
                 prednisolone; Meticortelone; Metacortandralone . . . 
                 C21H28O5 
               
               
                 ALDOSTERONE; Aldocortin; Electrocortin . . . 
                 C21H28O5 
               
               
                 fludrocortisone; Fluohydrisone; Fluorocortisol . . . 
                 C21H29FO5 
               
               
                 disopyramide; Dicorantil; Ritmodan . . . 
                 C21H29N3O 
               
               
                 biperiden; Akineton; Biperidene . . . 
                 C21H29NO 
               
               
                 Dronabinol; Marinol; Deltanyne . . . 
                 C21H30O2 
               
               
                 progesterone; Crinone; Luteohormone . . . 
                 C21H30O2 
               
               
                 hydrocortisone; Cortisol; Cortef . . . 
                 C21H30O5 
               
               
                 lisinopril; Prinivil; Zestril . . . 
                 C21H31N3O5 
               
               
                 buspirone; Ansial; Buspirona . . . 
                 C21H31N5O2 
               
               
                 ALFENTANIL; Alfentanyl; Alfenta . . . 
                 C21H32N6O3 
               
               
                 oxyphenonium; Methacin; Oxiphenonum . . . 
                 C21H34NO3+ 
               
               
                 Hemabate; C21H36O5; 15-Methyl-PGF2alpha . . . 
                 C21H36O5 
               
               
                 clotrimazole; Lotrimin; Mycelex . . . 
                 C22H17ClN2 
               
               
                 bifonazole; Mycospor; Trifonazole . . . 
                 C22H18N2 
               
               
                 Rilpivirine; TMC278; TMC 278 . . . 
                 C22H18N6 
               
               
                 Tadalafil; Cialis; Tadanafil . . . 
                 C22H19N3O4 
               
               
                 Rimonabant; Acomplia; Zimulti . . . 
                 C22H21Cl3N4O 
               
               
                 Cinacalcet; 226256-56-0; Cinacalcet [INN] . . . 
                 C22H22F3N 
               
               
                 droperidol; Droleptan; Inapsine . . . 
                 C22H22FN3O2 
               
               
                 ceftazidime; Fortaz; ceftazidima . . . 
                 C22H22N6O7S2 
               
               
                 podophyllotoxin; Podofilox; Condylox . . . 
                 C22H22O8 
               
               
                 loratadine; Claritin; Loratidine . . . 
                 C22H23ClN2O2 
               
               
                 losartan; Lortaan; Hyzaar . . . 
                 C22H23ClN6O 
               
               
                 Nesbuvir; HCV-796; Nesbuvir (USAN) . . . 
                 C22H23FN2O5S 
               
               
                 Erlotinib; 183321-74-6; N-(3-Ethynylphenyl)-6,7-bis(2- 
                 C22H23N3O4 
               
               
                 methoxyethoxy)quinazolin-4-amine . . . 
               
               
                 Vandetanib; Zactima; 443913-73-3 . . . 
                 C22H24BrFN4O2 
               
               
                 Gefitinib; Iressa; 184475-35-2 . . . 
                 C22H24ClFN4O3 
               
               
                 azelastine; Azelastinum [INN-Latin]; Azelastina [INN-Spanish] . . . 
                 C22H24ClN3O 
               
               
                 domperidone; Motilium; Nauzelin . . . 
                 C22H24ClN5O2 
               
               
                 Zuclopenthixol; Clopixol; Zuclopentixol [Spanish] . . . 
                 C22H25ClN2OS 
               
               
                 Nebivolol; Nebilet; Lobivon . . . 
                 C22H25F2NO4 
               
               
                 MORICIZINE; Moracizine; Ethmozine . . . 
                 C22H25N3O4S 
               
               
                 Ertapenem; Invanz; Ertapenem (INN) . . . 
                 C22H25N3O7S 
               
               
                 Tamibarotene; Am 80; Tamibaro . . . 
                 C22H25NO3 
               
               
                 Dasatinib; Sprycel; BMS-354825 . . . 
                 C22H26ClN7O2S 
               
               
                 FLUPHENAZINE; Triflumethazine; Fluorfenazine . . . 
                 C22H26F3N3OS 
               
               
                 Eletriptan; Relpax; eletriptanum . . . 
                 C22H26N2O2S 
               
               
                 diltiazem; Cardizem; Anoheal . . . 
                 C22H26N2O4S 
               
               
                 cyproterone; Gen-Cyproterone; CyPat . . . 
                 C22H27ClO3 
               
               
                 Sunitinib; Sutent; SU-11248 . . . 
                 C22H27FN4O2 
               
               
                 danazol; Danocrine; Cyclomen . . . 
                 C22H27NO2 
               
               
                 Amineptine; Amineptin; Amineptino . . . 
                 C22H27NO2 
               
               
                 fentanyl; Duragesic; Fentanest . . . 
                 C22H28N2O 
               
               
                 ANILERIDINE; Alidine; Leritin . . . 
                 C22H28N2O2 
               
               
                 Etonitazene; Etonitazine; Etonitazinum . . . 
                 C22H28N4O3 
               
               
                 mitoxantrone; Mitozantrone; Dihydroxyanthraquinone . . . 
                 C22H28N4O6 
               
               
                 Delavirdine; Rescriptor; 136817-59-9 . . . 
                 C22H28N6O3S 
               
               
                 desoximetasone; Topicort; Desoximetasona . . . 
                 C22H29FO4 
               
               
                 fluoromethoIone; Oxylone; FluormethoIone . . . 
                 C22H29FO4 
               
               
                 dexamethasone; Maxidex; Dexamethazone . . . 
                 C22H29FO5 
               
               
                 paramethasone; Cassenne; Cortiden . . . 
                 C22H29FO5 
               
               
                 betamethasone; Flubenisolone; Betadexamethasone . . . 
                 C22H29FO5 
               
               
                 thiethylperazine; Torecan; ETHYLTHIOPERAZINE . . . 
                 C22H29N3S2 
               
               
                 chlorhexidine; Tubulicid; Hexadol . . . 
                 C22H30Cl2N10 
               
               
                 APRINDINE; Aprinidine; Aprindin . . . 
                 C22H30N2 
               
               
                 SUFENTANIL; Chronogesic; Sufentanyl . . . 
                 C22H30N2O2S 
               
               
                 Spirapril; Renormax; Sandopril . . . 
                 C22H30N2O5S2 
               
               
                 sildenafil; Revatio; 139755-83-2 . . . 
                 C22H30N6O4S 
               
               
                 DESOGESTREL; Cerazette; desogen . . . 
                 C22H30O 
               
               
                 methylprednisolone; Medrol; Medrone . . . 
                 C22H30O5 
               
               
                 cilazapril; Inhibace; Cilazaprilum [Latin] . . . 
                 C22H31N3O5 
               
               
                 oxybutynin; Oxytrol; Ditropan . . . 
                 C22H31NO3 
               
               
                 benzquinamide; Quantril; Emete-con . . . 
                 C22H32N2O5 
               
               
                 medrysone; Hydroxymesterone; Medritonic . . . 
                 C22H32O3 
               
               
                 testosterone propionate; Agovirin; Testex . . . 
                 C22H32O3 
               
               
                 forskolin; Colforsin; Coleonol . . . 
                 C22H34O7 
               
               
                 tirofiban; Aggrastat; Tirofiban [BAN:INN] . . . 
                 C22H36N2O5S 
               
               
                 misoprostol; Cytotec; Arthrotec . . . 
                 C22H38O5 
               
               
                 amikacin; Amicacin; Amikavet . . . 
                 C22H43N5O13 
               
               
                 1-DOCOSANOL; Behenyl alcohol; Docosanol . . . 
                 C22H46O 
               
               
                 Brequinar; 96187-53-0; brequinarum [Latin] . . . 
                 C23H15F2NO2 
               
               
                 sulfinpyrazone; Sulphinpyrazone; Anturane . . . 
                 C23H20N2O3S 
               
               
                 chlorotrianisene; Chlortrianisestrol; Chlortrianizen . . . 
                 C23H21ClO3 
               
               
                 TASOSARTAN; 145733-36-4; Verdia . . . 
                 C23H21N7O 
               
               
                 topotecan; Hycamtin; Hycamptamine . . . 
                 C23H23N3O5 
               
               
                 doxazosin; Doxazosinum; Doxazosina . . . 
                 C23H25N5O5 
               
               
                 Aripiprazole; Abilify; Abilitat . . . 
                 C23H27Cl2N3O2 
               
               
                 risperidone; Risperdal; Risperidal . . . 
                 C23H27FN4O2 
               
               
                 Paliperidone; Invega; 9-Hydroxyrisperidone . . . 
                 C23H27FN4O3 
               
               
                 butenafine; Butenafina; Butenafinum . . . 
                 C23H27N 
               
               
                 piperacillin; Pipracil; Pipercillin . . . 
                 C23H27N5O7S 
               
               
                 glyburide; Glibenclamide; Glybenclamide . . . 
                 C23H28ClN3O5S 
               
               
                 Cinalukast; CHEBL126598; Cinalukast [USAN:INN] . . . 
                 C23H28N2O3S 
               
               
                 Forasartan; Forasartan (USAN/INN); UNII-065F7WPT0B . . . 
                 C23H28N8 
               
               
                 cisapride; Propulsid; Acenalin . . . 
                 C23H29ClFN3O4 
               
               
                 Tiotixene; Navane; cis-Thiothixene . . . 
                 C23H29N3O2S2 
               
               
                 mepacrine; quinacrine; atabrine . . . 
                 C23H30ClN3O 
               
               
                 propantheline; Propanthelinium; Propanthelinum . . . 
                 C23H30NO3+ 
               
               
                 Methadyl acetate; Acetylmethadol; ALPHACETYLMETHADOL . . . 
                 C23H31NO2 
               
               
                 Levacetylmethadol; Levomethadyl acetate; LAAM . . . 
                 C23H31NO2 
               
               
                 NORGESTIMATE; Dexnorgestrel acetime; Ortho-Prefest . . . 
                 C23H31NO3 
               
               
                 mycophenolate mofetil; CellCept; Munoloc . . . 
                 C23H31NO7 
               
               
                 ramipril; Tritace; Altace . . . 
                 C23H32N2O5 
               
               
                 Vardenafil; Levitra; 224785-90-4 . . . 
                 C23H32N6O4S 
               
               
                 finasteride; Proscar; Propecia . . . 
                 C23H36N2O2 
               
               
                 pravastatin; Pravastatine [French]; Pravastatinum [Latin] . . . 
                 C23H36O7 
               
               
                 paromomycin; Aminosidin; Paramomycin Sulfate . . . 
                 C23H45N5O14 
               
               
                 neomycin; NEOMYCIN B; Framycetin . . . 
                 C23H46N6O13 
               
               
                 candesartan; Biopress; 139481-59-7 . . . 
                 C24H20N6O3 
               
               
                 Ezetimibe; Zetia; Ezetrol . . . 
                 C24H21F2NO3 
               
               
                 eribaxaban; PD-0348292; 536748-46-6 . . . 
                 C24H22ClFN4O4 
               
               
                 Aleglitazar; Aleglitazar (USAN); 475479-34-6 . . . 
                 C24H23NO5S 
               
               
                 flavoxate; Urispas; Flavoxato . . . 
                 C24H25NO4 
               
               
                 nicergoline; Nicotergoline; Nimergoline . . . 
                 C24H26BrN3O3 
               
               
                 SERTINDOLE; SerLect; Serdolect . . . 
                 C24H26ClFN4O 
               
               
                 carvedilol; Coreg; Carvedilolum . . . 
                 C24H26N2O4 
               
               
                 troglitazone; Rezulin; Prelay . . . 
                 C24H27NO5S 
               
               
                 benazepril; Benazeprilum [Latin]; benazapril . . . 
                 C24H28N2O5 
               
               
                 Bexarotene; Targretin; Targrexin . . . 
                 C24H28O2 
               
               
                 valsartan; Diovan; 137862-53-4 . . . 
                 C24H29N5O3 
               
               
                 donepezil; Eranz; 120014-06-4 . . . 
                 C24H29NO3 
               
               
                 FLUOCINOLONE ACETONIDE; Synandone; Fluonid . . . 
                 C24H30F2O6 
               
               
                 doxapram; Dopram; 309-29-5 . . . 
                 C24H30N2O2 
               
               
                 Drospirenone; Dihydrospirorenone; Dehydrospirorenone . . . 
                 C24H30O3 
               
               
                 Loteprednol etabonate; Lotemax; Alrex . . . 
                 C24H31ClO7 
               
               
                 flunisolide; Nasalide; Aerobid . . . 
                 C24H31FO6 
               
               
                 Carphenazine; Carfenazine; Carphenazin . . . 
                 C24H31N3O2S 
               
               
                 ETHYNODIOL DIACETATE; Continuin; Femulen . . . 
                 C24H32O4 
               
               
                 spironolactone; Aldactone; Verospiron . . . 
                 C24H32O4S 
               
               
                 DESONIDE; DesOwen; Tridesilon . . . 
                 C24H32O6 
               
               
                 RANOLAZINE; Ranexa; 95635-55-5 . . . 
                 C24H33N3O4 
               
               
                 bepridil; Bepadin; Vascor . . . 
                 C24H34N2O 
               
               
                 trandolapril; Mavik; Gopten . . . 
                 C24H34N2O5 
               
               
                 glimepiride; Amaryl; Amarel . . . 
                 C24H34N4O5S 
               
               
                 Org-6216; Vexol (TN); AC1NSKKX . . . 
                 C24H34O3 
               
               
                 Nabilone; Cesamet; 51022-71-0 . . . 
                 C24H36O3 
               
               
                 lovastatin; mevinolin; Mevacor . . . 
                 C24H36O5 
               
               
                 dipyridamole; Persantin; Curantyl . . . 
                 C24H40N8O4 
               
               
                 chenodeoxycholic acid; Chenodiol; Chenix . . . 
                 C24H40O4 
               
               
                 ursodiol; URSODEOXYCHOLIC acid; Actigall . . . 
                 C24H40O4 
               
               
                 Apixaban; 503612-47-3; Eliquis . . . 
                 C25H25N5O4 
               
               
                 meclizine; Meclozine; Parachloramine . . . 
                 C25H27ClN2 
               
               
                 irbesartan; Avapro; Aprovel . . . 
                 C25H28N6O 
               
               
                 amiodarone; Cordarone; Amiodarona . . . 
                 C25H29I2NO3 
               
               
                 quinapril; Quinaprilum [Latin]; Quinaprilum . . . 
                 C25H30N2O5 
               
               
                 FLUTICASONE PROPIONATE; Cutivate; Flonase . . . 
                 C25H31F3O5S 
               
               
                 CLOBETASOL PROPIONATE; Clobex; Embeline . . . 
                 C25H32ClFO5 
               
               
                 nefazodone; Nefazodonum [Latin]; Nefazodona [Spanish] . . . 
                 C25H32ClN5O2 
               
               
                 QUINESTROL; Estrovis; Estrovister . . . 
                 C25H32O2 
               
               
                 amprenavir; Agenerase; Prozei . . . 
                 C25H35N3O6S 
               
               
                 Fosamprenavir; Telzir; Fosamprenavir [INN] . . . 
                 C25H36N3O9PS 
               
               
                 Udenafil; Zydena; DA-8159 . . . 
                 C25H36N6O4S 
               
               
                 Salmeterol; Astmerole; Serevent . . . 
                 C25H37NO4 
               
               
                 Bimatoprost; Lumigan; Latisse . . . 
                 C25H37NO4 
               
               
                 flunarizine; Sibelium; Flunarizinum [INN-Latin] . . . 
                 C26H26F2N2 
               
               
                 IDARUBICIN; Idamycin; idarubicin hydrochloride . . . 
                 C26H27NO9 
               
               
                 Ketoderm; Panfungol; Orifungal M . . . 
                 C26H28Cl2N4O4 
               
               
                 Zuclomiphene; Cisclomiphene; Zuclomifene . . . 
                 C26H28ClNO 
               
               
                 toremifene; Acapodene; Farestone . . . 
                 C26H28ClNO 
               
               
                 cinnarizine; Stugeron; Dimitronal . . . 
                 C26H28N2 
               
               
                 ALMITRINE; Almitrin; Vectarion . . . 
                 C26H29F2N7 
               
               
                 levocabastine; Livostin; Levocabastinum [Latin] . . . 
                 C26H29FN2O2 
               
               
                 nicardipine; Nicardipinum [INN-Latin]; Nicardipino [INN-Spanish] . . . 
                 C26H29N3O6 
               
               
                 tamoxifen; Crisafeno; Diemon . . . 
                 C26H29NO 
               
               
                 Halofantrine; Halfan; Halofantrine [USAN] . . . 
                 C26H30Cl2F3NO 
               
               
                 terconazole; Triaconazole; Terazol . . . 
                 C26H31Cl2N5O3 
               
               
                 Diflorasone diacetate; Florone; Psorcon . . . 
                 C26H32F2O7 
               
               
                 fluocinonide; Lidex; Fluocinolide . . . 
                 C26H32F2O7 
               
               
                 cerivastatin; Lipobay; cerivastatin acid . . . 
                 C26H34FNO5 
               
               
                 Travoprost; Travatan; Travatan Z . . . 
                 C26H35F3O6 
               
               
                 cabergoline; Dostinex; Cabaser . . . 
                 C26H37N5O2 
               
               
                 Mupirocin; Pseudomonic acid; Bactroban . . . 
                 C26H44O9 
               
               
                 clofazimine; Lamprene; Lampren . . . 
                 C27H22Cl2N4 
               
               
                 Bosentan; Tracleer; 147536-97-8 . . . 
                 C27H29N5O6S 
               
               
                 daunorubicin; Daunomycin; Rubidomycin . . . 
                 C27H29NO10 
               
               
                 doxorubicin; Adriamycin; Adriblastina . . . 
                 C27H29NO11 
               
               
                 Gliquidone; Glurenorm; glikvidon . . . 
                 C27H33N3O6S 
               
               
                 MOEXIPRIL; Moexiprilum [INN-Latin]; 103775-10-6 . . . 
                 C27H34N2O7 
               
               
                 Locorten; FLU METHASONE PIVALATE; Locacorten . . . 
                 C27H36F2O6 
               
               
                 Repaglinide; Prandin; NovoNorm . . . 
                 C27H36N2O4 
               
               
                 Darunavir; Prezista; TMC-114 . . . 
                 C27H37N3O7S 
               
               
                 VERAPAMIL; Iproveratril; Cordilox . . . 
                 C27H38N2O4 
               
               
                 Paricalcitol; Zemplar; 19-Nor-1alpha,25-dihydroxyvitamin D2 . . . 
                 C27H44O3 
               
               
                 raloxifene; Keoxifene; Raloxifenum [Latin] . . . 
                 C28H27NO4S 
               
               
                 ADAPALENE; Differin; Adaferin . . . 
                 C28H28O3 
               
               
                 pimozide; Orap; Opiran . . . 
                 C28H29F2N3O 
               
               
                 Darifenacin; Emselex; CHEBL391960 . . . 
                 C28H30N2O2 
               
               
                 astemizole; Hismanal; Alermizol . . . 
                 C28H31FN4O 
               
               
                 Buclizine; Vibazine; Histabuticine . . . 
                 C28H33ClN2 
               
               
                 amcinonide; Cyclocort; amcinonida . . . 
                 C28H35FO7 
               
               
                 Plerixafor; Mozobil; AMD3100 . . . 
                 C28H54N8 
               
               
                 Lapatinib; Tykerb; 231277-92-2 . . . 
                 C29H26ClFN4O4S 
               
               
                 Olmesartan medoxomil; Benicar; 144689-63-4 . . . 
                 C29H30N6O6 
               
               
                 Fluspirilene; Redeptin; Imap . . . 
                 C29H31F2N3O 
               
               
                 Imatinib; 152459-95-5; sti-571 . . . 
                 C29H31N7O 
               
               
                 etoposide; VePesid; Lastet . . . 
                 C29H32O13 
               
               
                 Ioperamide; Ioperamide; Loperacap . . . 
                 C29H33ClN2O2 
               
               
                 mifepristone; Mifeprex; Mifegyne . . . 
                 C29H35NO2 
               
               
                 Mibefradil; Posicor; Mibefradil [INN:BAN] . . . 
                 C29H38FN3O3 
               
               
                 Maraviroc; Celsentri; Selzentry . . . 
                 C29H41F2N5O 
               
               
                 Candoxatril; CHEBL3353; AC1NSFYL . . . 
                 C29H41NO7 
               
               
                 orlistat; Xenical; Tetrahydrolipstatin . . . 
                 C29H53NO5 
               
               
                 lividomycin A; Lividomycin; Quintomycin B . . . 
                 C29H55N5O18 
               
               
                 DIPHENOXYLATE; Difenossilato [DCIT]; Difenoxilato . . . 
                 C30H32N2O2 
               
               
                 Aliskiren; Rasilez; Tekturna . . . 
                 C30H53N3O6 
               
               
                 Tipranavir; Aptivus; PNU-140690 . . . 
                 C31H33F3N2O5S 
               
               
                 zafirlukast; Accolate; 107753-78-6 . . . 
                 C31H33N3O6S 
               
               
                 Doramapimod; BIRB-796; BIRB 796 . . . 
                 C31H37N5O3 
               
               
                 probucol; Lorelco; Biphenabid . . . 
                 C31H48O2S2 
               
               
                 fusidic acid; Fusidine; Ramycin . . . 
                 C31H48O6 
               
               
                 Conivaptan; YM 087; YM087 . . . 
                 C32H26N4O2 
               
               
                 DESERPIDINE; Harmonyl; Raunormine . . . 
                 C32H38N2O8 
               
               
                 fexofenadine; Carboxyterfenadine; Terfenadine-COOH . . . 
                 C32H39NO4 
               
               
                 bromocriptine; Bromocriptin; Bromocryptine . . . 
                 C32H40BrN5O5 
               
               
                 terfenadine; Seldane; Triludan . . . 
                 C32H41NO2 
               
               
                 nelfinavir; 159989-64-7; AG1343 . . . 
                 C32H45N3O4S 
               
               
                 Fulvestrant; Faslodex; ICI 182,780 . . . 
                 C32H47F5O3S 
               
               
                 Telmisartan; Micardis; Pritor . . . 
                 C33H30N4O2 
               
               
                 atorvastatin; Cardyl; Sotis . . . 
                 C33H35FN2O5 
               
               
                 Ergotamin; Ergostat; Gynergen . . . 
                 C33H35N5O5 
               
               
                 dihydroergotamine; Ergomimet; Orstanorm . . . 
                 C33H37N5O5 
               
               
                 irinotecan; Camptosar; (+)-Irinotecan . . . 
                 C33H38N4O6 
               
               
                 reserpine; Serpasil; Serpalan . . . 
                 C33H40N2O9 
               
               
                 montelukast; Montair; Singular . . . 
                 C35H36ClNO3S 
               
               
                 itraconazole; Sporanox; Oriconazole . . . 
                 C35H38Cl2N8O4 
               
               
                 rescinnamine; Rescinnamine; Moderil . . . 
                 C35H42N2O9 
               
               
                 ENALKIREN; Enalquireno; Abbott-64662 . . . 
                 C35H56N6O6 
               
               
                 Lercanidipine; Lercanidipine [INN]; masnidipine . . . 
                 C36H41N3O6 
               
               
                 indinavir; Compound J; Crixivan . . . 
                 C36H47N5O4 
               
               
                 tubocurarine; d-Tubocurarine; Tubocurarin . . . 
                 C37H41N2O6+ 
               
               
                 Lopinavir; Aluviran; ABT-378 . . . 
                 C37H48N4O5 
               
               
                 ritonavir; Norvir; Norvir Sec . . . 
                 C37H48N6O5S2 
               
               
                 erythromycin; erythromycin A; Erymax . . . 
                 C37H67NO13 
               
               
                 Atazanavir; Latazanavir; Zrivada . . . 
                 C38H52N6O7 
               
               
                 digitoxin; Digitoxoside; Crystodigin (TN) . . . 
                 C41H64O13 
               
               
                 TROLEANDOMYCIN; Triacetyloleandomycin; Matromicina . . . 
                 C41H67NO15 
               
               
                 Leucomycin A3; Turimycin A5; josamycin . . . 
                 C42H69NO15 
               
               
                 Rifaximin; Rifaxidin; Xifaxan . . . 
                 C43H51N3O11 
               
               
                 docetaxel; Taxotere; Docetaxel anhydrous . . . 
                 C43H53NO14 
               
               
                 vindesine; Desacetylvinblastine amide; Vindesin . . . 
                 C43H55N5O7 
               
               
                 vinorelbine; Navelbine base; Navelbine . . . 
                 C45H54N4O8 
               
               
                 vincristine; Leurocristine; 22-Oxovincaleukoblastine . . . 
                 C46H56N4O10 
               
               
                 RIFABUTIN; Ansamycin; Mycobutin . . . 
                 C46H62N4O11 
               
               
                 TAXOL; paclitaxel; Abraxane . . . 
                 C47H51NO14 
               
               
                 Priftin; RIFAPENTINE; Cyclopentyl rifampin . . . 
                 C47H64N4O12 
               
               
                 amphotericin b; Amphotericin; Ambisome . . . 
                 C47H73NO17 
               
               
                 Terlipressin; glypressin; Lucassin . . . 
                 C52H74N16O15S2 
               
               
                 Anidulafungin; Eraxis; Ecalta . . . 
                 C58H73N7O17 
               
               
                 Mivacurium; MIVACURIUM CHLORIDE; AC1NQXXZ . . . 
                 C58H80N2O14 + 2