Patent Publication Number: US-11653863-B2

Title: Fluid control devices and methods of using the same

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application is a continuation of U.S. patent application Ser. No. 17/390,249 entitled, “Fluid Control Devices and Methods of Using the Same,” filed Jul. 30, 2021, which is a continuation of U.S. patent application Ser. No. 16/129,066 entitled, “Fluid Control Devices and Methods of Using the Same,” filed Sep. 12, 2018 (now U.S. Pat. No. 11,076,787), which claims priority to and the benefit of U.S. Provisional Patent Application Ser. No. 62/678,632 entitled, “Fluid Control Devices and Methods of Using the Same,” filed May 31, 2018, U.S. Provisional Patent Application Ser. No. 62/634,569 entitled, “Fluid Control Devices and Methods of Using the Same,” filed Feb. 23, 2018, and U.S. Provisional Patent Application Ser. No. 62/557,530 entitled, “Fluid Control Devices and Methods of Using the Same,” filed Sep. 12, 2017, the disclosure of each of which is incorporated herein by reference in its entirety. 
     This application also claims priority to and the benefit of U.S. Provisional Patent Application Ser. No. 62/634,569 entitled, “Fluid Control Devices and Methods of Using the Same,” filed Feb. 23, 2018, the disclosure of which is incorporated herein by reference in its entirety. 
     This application also claims priority to and the benefit of U.S. Provisional Patent Application Ser. No. 62/678,632 entitled, “Fluid Control Devices and Methods of Using the Same,” filed May 31, 2018, the disclosure of which is incorporated herein by reference in its entirety. 
    
    
     BACKGROUND 
     The invention relates generally to the parenteral procurement of bodily fluid samples, and more particularly to fluid diversion, sequestration, and/or isolation devices and methods for procuring bodily fluid samples with reduced contaminants such as dermally residing microbes and/or other contaminants exterior to the bodily fluid source. 
     Health care practitioners routinely perform various types of microbial as well as other broad diagnostic tests on patients using parenterally obtained bodily fluids. As advanced diagnostic technologies evolve and improve, the speed, accuracy (both sensitivity and specificity), and value of information that can be provided to clinicians continues to improve. Maintaining the integrity of the bodily fluid sample during and/or after collection also ensures that analytical diagnostic results are representative of the in vivo conditions of a patient. Examples of diagnostic technologies that are reliant on high quality, non-contaminated, and/or unadulterated bodily fluid samples include but are not limited to microbial detection, molecular diagnostics, genetic sequencing (e.g., deoxyribonucleic acid (DNA), ribonucleic acid (RNA), next-generation sequencing (NGS), etc.), biomarker identification, and the like. When biological matter, which can include cells external to the intended source for sample procurement, and/or other external contaminants are inadvertently included in the bodily fluid sample that is to be analyzed, there is an opportunity for inaccurate test results to be derived. In short, when the purity of the sample intended to be derived or collected from a specific bodily fluid source is compromised during the specimen procurement process, resultant analytical test results may be inaccurate, distorted, adulterated, falsely positive, falsely negative, and/or otherwise not representative of the actual condition of the patient, which in turn, can inform faulty, inaccurate, confused, unsure, low-confidence, and/or otherwise undesired clinical decision making. 
     In some instances, patient samples (e.g., bodily fluids) are tested for the presence of one or more potentially undesirable microbes, such as bacteria, fungi, or yeast (e.g.,  Candida ). In some instances, microbial testing may include incubating patient samples in one or more sterile and/or non-sterile vessels that may contain culture media, common additives, and/or other types of solutions that are conducive to microbial growth. In other instances, the sample in the vessel may be analyzed directly (i.e., not incubated) and may not contain culture media or additives associated with incubating the specimen. In still other instances, various technologies can be employed to assist in the detection of the presence of microbes as well as other types of biological matter, specific types of cells, biomarkers, proteins, antigens, enzymes, blood components, and/or the like during diagnostic testing. Examples include but are not limited to molecular polymerase chain reaction (PCR), magnetic resonance and other magnetic analytical platforms, automated microscopy, spatial clone isolation, flow cytometry, whole blood (“culture free”) specimen analysis (e.g. NGS) and associated technologies, morphokinetic cellular analysis, and/or other common or evolving and advanced technologies utilized in the clinical laboratory environment to characterize patient specimens and/or to detect, identify, type, categorize, and/or characterize specific organisms, antibiotic susceptibilities, and/or the like. 
     In some instances, the detection of the presence of microbes includes allowing the microbes and/or organisms to grow for an amount of time (e.g., a variable amount of time from less than an hour to a few hours to several days—which can be longer or shorter depending on the diagnostic technology employed). The microbe and/or organism growth can then be detected by automated, continuous monitoring, and/or other methods specific to the analytical platform and technology used for detection, identification, and/or the like. 
     In culture testing, for example, when microbes are present in the patient sample, the microbes flourish over time in the culture medium and, in some instances, automated monitoring technologies can detect carbon dioxide produced by organism growth. The presence of microbes in the culture medium (as indicated by observation of carbon dioxide and/or via other detection methods) suggests the presence of the same microbes in the patient sample which, in turn, suggests the presence of the same microbes in the bodily fluid of the patient from whom the sample was obtained. Accordingly, when microbes are determined to be present in the culture medium (or more generally in the sample used for testing), the patient may be diagnosed and prescribed one or more antibiotics or other treatments specifically designed to treat or otherwise remove the undesired microbes from the patient. 
     Patient samples, however, can become contaminated during procurement and/or otherwise can be susceptible to false positive or false negative results. For example, microbes from a bodily surface (e.g., dermally residing microbes) that are dislodged during the specimen procurement process (which can include needle insertion into a patient, specimen procurement via a lumen-containing device such as a peripheral IV catheter (PIV), a central line (PICC) and/or other indwelling catheter(s), collection with a syringe or any other suitable means employed to collect a patient specimen), either directly or indirectly via tissue fragments, hair follicles, sweat glands, and other skin adnexal structures, can be subsequently transferred to a culture medium, test vial, or other suitable specimen collection or transfer vessel with the patient sample and/or included in the specimen that is to be analyzed for non-culture based testing. Another possible source of contamination is from the person drawing the patient sample (e.g., a doctor, phlebotomist, nurse, technician, etc.). Specifically, equipment, supplies, and/or devices used during a patient sample procurement process often include multiple fluidic interfaces (by way of example, but not limited to, patient to needle, needle to transfer adapter, transfer adapter to sample vessel, catheter hub to syringe, syringe to transfer adapter, needle/tubing to sample vessels, and/or any other fluidic interface or any combination thereof) that can each introduce points of potential contamination. In some instances, such contaminants may thrive in a culture medium and/or may be identified by another non-culture based diagnostic technology and eventually may yield a false positive and/or a false negative microbial test result, which may inaccurately reflect the presence or lack of such microbes within the patient (i.e., in vivo). 
     Such inaccurate results because of contamination and/or other sources of adulteration that compromise the purity of the sample are a concern when attempting to diagnose or treat a wide range of suspected illnesses, diseases, infections, patient conditions or other maladies of concern. For example, false negative results from microbial tests may result in a misdiagnosis and/or delayed treatment of a patient illness, which, in some cases, could result in the death of the patient. Conversely, false positive results from microbial tests may result in the patient being unnecessarily subjected to one or more anti-microbial therapies, which may cause serious side effects to the patient including, for example, death, as well as produce an unnecessary burden and expense to the health care system due to extended length of patient stay and/or other complications associated with erroneous treatments. The use of diagnostic imaging equipment attributable to these false positive results is also a concern from both a cost as well as patient safety perspective as unnecessary exposure to concentrated radiation associated with a variety of imaging procedures (e.g., CT scans) has many known adverse impacts on long-term patient health. 
     In some instances, devices and/or systems can be used to reduce the likelihood of contamination, adulteration, and/or the like of bodily fluid samples for testing. For example, some known devices can be configured to collect, divert, separate, and/or isolate or sequester an initial volume of bodily fluid that may be more likely to contain contaminants such as dermally residing microbes or the like. Some such devices, however, can be cumbersome, non-intuitive, perceived as difficult to use, inappropriate or unusable as intended for the target patient population, etc. In addition, some such devices can require training, user observation, intervention by more than one user, and/or can otherwise present challenges that can lead to limited efficacy based on variables including environmental, educational, clinician skill, patient condition, and/or the like. In some instances, such challenges can complicate the collection of consistently high quality samples that are non-contaminated, sterile, unadulterated, etc., which in turn, can impact the validity of test result outcomes. 
     On the other hand, some known passive diversion devices and/or systems (e.g., systems that do not specifically utilize or rely on direct user intervention, interaction, manipulation, and/or the like) may fail to adequately divert, sequester, and/or isolate a clinically desired and efficacious pre-sample volume of bodily fluid due to clinical realities such as, for example, the time required to fill a sequestration reservoir with a meaningful volume of fluid. In some instances, the operation of some known passive devices is dependent on a positive pressure applied by a bodily fluid source (e.g., a patient&#39;s blood pressure). The positive pressure applied by the bodily fluid source, however, may be insufficient to result in flow dynamics and/or flow rates that makes use of such devices practical in various clinical settings (including emergency rooms and other intensive settings). For example, the patient population with symptoms requiring diagnostic testing noted above commonly are in such physical condition that attaining vascular access and/or collection of bodily fluid samples can be difficult due to a hypotensive state (i.e., low blood pressure), hypovolemic state (i.e., low blood volume), and/or other physical challenges (e.g., severe dehydration, obesity, difficult and/or inaccessible vasculature, etc.). Such states or physical conditions can result in difficulty in providing sufficient blood flow and/or pressure to achieve passive filling of a sequestration chamber, channel, reservoir, container (or other diversion volume) consistently with sufficient volume to meet clinically validated, evidence-based efficacy and results in diverting, sequestering, and/or isolating contaminants which otherwise can lead to distorted, inaccurate, falsely positive, falsely negative, and/or otherwise adulterated diagnostic test results. The challenges associated with this approach (e.g., relying on a positive pressure differential applied by the bodily fluid source without utilizing a specific external energy source and/or negative pressure to facilitate collection of an appropriate and clinically efficacious initial volume of bodily fluid) can render it impractical as failure rates can be unacceptably high for the fragile patient population from whom these samples are collected. 
     As such, a need exists for fluid diversion devices and methods for procuring bodily fluid samples with reduced contaminants such as dermally residing microbes and/or other contaminants exterior to the bodily fluid source that result in consistent bodily fluid collection (e.g., from a general patient population and/or a challenging patient population). Some such devices and methods can include, for example, bodily fluid collection with the assistance of various sources of external energy and/or negative pressure. Furthermore, a need exists for such devices that are user-friendly, demonstrate consistent efficacy, and address the challenges associated with collecting samples from patients with challenging health circumstances and/or physical characteristics that impact the ability to collect bodily fluid samples. 
     SUMMARY 
     Devices and methods for procuring bodily fluid samples with reduced contaminants such as dermally residing microbes and/or other contaminants exterior to the bodily fluid source are described herein. In some embodiments, a system includes a housing, a flow controller, and a fluid collection device. The housing has an inlet and an outlet, and forms a sequestration portion. The inlet is configured to be placed in fluid communication with a bodily fluid source. The sequestration portion is configured to receive an initial volume of bodily fluid from the bodily fluid source. The flow controller is at least partially disposed in the sequestration portion of the housing and is configured to transition from a first state to a second state. The fluid collection device is configured to be fluidically coupled to the outlet to produce a negative pressure differential within at least a portion of the housing. The negative pressure differential is operable to draw the initial volume of bodily fluid into the sequestration portion when the flow controller is in the first state and is operable to draw the sample volume of bodily fluid through the outlet and into the fluid collection device when the flow controller is in the second state. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG.  1    is a schematic illustration of a fluid control device according to an embodiment. 
         FIGS.  2 - 5    are various views of a fluid control device according to an embodiment. 
         FIGS.  6 - 8    are various views of a fluid control device according to an embodiment. 
         FIGS.  9  and  10    are front view illustrations of a fluid control device in a first operating mode and a second operating mode, respectively, according to an embodiment. 
         FIGS.  11  and  12    are front view illustrations of a fluid control device in a first operating mode and a second operating mode, respectively, according to an embodiment. 
         FIGS.  13 - 15 B  are various views of a fluid control device according to an embodiment. 
         FIGS.  16 - 18    are various views of a fluid control device according to an embodiment. 
         FIGS.  19 - 25    are various views of a fluid control device according to an embodiment. 
         FIGS.  26 - 28    are each a perspective view of a fluid control device according to different embodiments. 
         FIGS.  29 - 34    are various views of a fluid control device according to an embodiment. 
         FIGS.  35 - 40    are various views of a fluid control device according to an embodiment. 
         FIGS.  41 - 44    are various views of a fluid control device according to an embodiment. 
         FIGS.  45 - 50    are various views of a fluid control device according to an embodiment. 
         FIGS.  51  and  52    are cross-sectional views of a fluid control device according to an embodiment. 
         FIG.  53    is a flowchart illustrating a method of using a fluid control device according to an embodiment. 
     
    
    
     DETAILED DESCRIPTION 
     Devices and methods for collecting, diverting, sequestering, isolating, etc. an initial volume of bodily fluid to reduce contamination in subsequently procured bodily fluid samples are described herein. Any of the fluid control devices described herein can be configured to receive, procure, and/or transfer a flow, bolus, volume, etc., of bodily fluid. A first reservoir, channel, flow path, or portion of the device can receive an initial amount of the bodily fluid flow, which then can be substantially or fully sequestered (e.g., contained or retained, circumvented, isolated, segregated, vapor-locked, separated, and/or the like) in or by the first reservoir or first portion of the device. In some instances, contaminants such as dermally residing microbes or the like can be included and/or entrained in the initial amount of the bodily fluid and likewise are sequestered in or by the first reservoir or first portion of the device. Once the initial amount is sequestered, any subsequent amount of the bodily fluid flow can be diverted, channeled, directed, flow controlled (e.g., manually, automatically, and/or semi-automatically) to a second reservoir, second portion of the device, and/or any additional flow path(s). Thus, with the initial amount sequestered, any additional and/or subsequent amount(s) of bodily fluid flow are substantially free from contaminants that may otherwise produce inaccurate, distorted, adulterated, falsely positive, falsely negative, etc., results in some diagnostics and/or testing. In some instances, the initial amount of bodily fluid also can be used, for example, in other testing such as those less affected by the presence of contaminants, can be discarded as a waste volume, can be infused back into the patient, and/or can be used for any other suitable clinical application. 
     In some embodiments, a feature of the fluid control devices and/or methods described herein is the use of an external negative pressure source (e.g., provided by a fluid collection device or any other suitable means) to (1) overcome physical patient challenges which can limit and/or prevent a sufficient pressure differential (e.g., a differential in blood pressure to ambient air pressure) to fully engage the sequestration chamber and/or to transition fluid flow to the fluid collection device; (2) result in proper filling of the sequestration chamber with a clinically validated and/or desirable volume of bodily fluid; (3) result in efficient, timely, and/or user-accepted consistency with bodily fluid collection process; and/or (4) provide a means of manipulating and/or automatically transitioning fluid flow (e.g., movement of physical components of the system or changing, switching, engaging, and/or otherwise employing or achieving desired fluid flow dynamics) to enable sequestration and/or isolation of the initial sample and collection of a subsequent sample. 
     In some embodiments, a fluid control device includes an inlet and an outlet. The inlet is configured to be placed in fluid communication with a bodily fluid source or an intermediary bodily fluid transfer device and the outlet is configured to be placed in fluid communication with a fluid collection device such as, for example, a sample reservoir, a syringe, a lumen-containing device, and/or any other suitable bodily fluid collection and/or transfer device. The fluid control device has a first state in which a negative pressure differential produced from an external source (e.g., the fluid collection device such as a sample reservoir, a syringe, a vessel, and/or any suitable intermediary fluid reservoir) is applied to the fluid control device to draw an initial volume of bodily fluid from the bodily fluid source, through the inlet, and into a sequestration and/or diversion portion of the fluid control device (which can be formed by or in the fluid control device or coupled thereto). The fluid control device has a second state in which (1) the sequestration chamber sequesters the initial volume, and (2) the negative pressure differential draws a subsequent volume of bodily fluid, being substantially free of contaminants, from the bodily fluid source, through the fluid control device, and into the fluid collection device. 
     In some embodiments, a system includes a housing, a flow controller, and a fluid collection device. The housing has an inlet and an outlet, and forms a sequestration portion. The inlet is configured to be placed in fluid communication with a bodily fluid source. The sequestration portion is configured to receive an initial volume of bodily fluid from the bodily fluid source. The flow controller is at least partially disposed in the sequestration portion of the housing and is configured to transition from a first state to a second state. The fluid collection device is configured to be fluidically coupled to the outlet to produce a negative pressure differential within at least a portion of the housing. The negative pressure differential is operable to draw the initial volume of bodily fluid into the sequestration portion when the flow controller is in the first state and is operable to draw the sample volume of bodily fluid through the outlet and into the fluid collection device when the flow controller is in the second state. 
     In some embodiments, an apparatus includes a housing and an actuator coupled to the housing. The housing has an inlet configured to be placed in fluid communication with a bodily fluid source and an outlet configured be placed in fluid communication with a fluid collection device. The housing forms a sequestration portion that is configured to receive an initial volume of bodily fluid from the bodily fluid source. The actuator has a first configuration in which a first fluid flow path places the inlet in fluid communication with the sequestration portion and a second configuration in which a second fluid flow path places the inlet in fluid communication with the outlet. The fluid collection device is configured to be placed in fluid communication with the outlet to produce a negative pressure differential (1) within the first fluid flow path that is operable to draw the initial volume of bodily fluid into the sequestration portion when the actuator is in the first configuration, and (2) within the second fluid flow path that is operable to draw a sample volume of bodily fluid into the fluid collection device when the actuator is in the second configuration. 
     In some embodiments, a method of using a fluid control device to obtain a bodily fluid sample with reduced contamination includes establishing fluid communication between a bodily fluid source and an inlet of the fluid control device. A fluid collection device is coupled to an outlet of the fluid control device and is configured to produce a negative pressure differential within at least a portion of the fluid control device. An initial volume of bodily fluid is received from the inlet and into a sequestration portion of the fluid control device in response to the negative pressure differential. In response to contact with a portion of the initial volume of bodily fluid, a flow controller disposed in the sequestration portion is transitioned from a first state in which the flow controller allows a flow of a gas through the flow controller and prevents a flow of bodily fluid through the flow controller, to a second state in which the flow controller prevents a flow of gas and bodily fluid through the flow controller. The initial volume of bodily fluid is sequestered in the sequestration portion after the flow controller is transitioned to the second state and a subsequent volume of bodily fluid is transferred from the inlet to an outlet in fluid communication with a fluid collection device. 
     As used in this specification and the claims, the singular forms “a,” “an” and “the” include plural referents unless the context clearly dictates otherwise. Thus, for example, the term “a member” is intended to mean a single member or a combination of members, “a material” is intended to mean one or more materials, or a combination thereof. 
     As used herein, the terms “about,” “approximate,” and/or “substantially” when used in connection with stated value and/or other geometric relationships is intended to convey that the structure so defined is nominally the value stated and/or the geometric relationship described. In some instances, the terms “about,” “approximately,” and/or “substantially” can generally mean and/or can generally contemplate plus or minus 10% of the value or relationship stated. For example, about 0.01 would include 0.009 and 0.011, about 0.5 would include 0.45 and 0.55, about 10 would include 9 to 11, and about 1000 would include 900 to 1100. While a value stated may be desirable, it should be understood that some variance may occur as a result of, for example, manufacturing tolerances or other practical considerations (such as, for example, the pressure or force applied through a portion of a device, conduit, lumen, etc.). Accordingly, the terms “about,” “approximately,” and/or “substantially” can be used herein to account for such tolerances and/or considerations. 
     As used herein, “bodily fluid” can include any fluid obtained directly or indirectly from a body of a patient. For example, “bodily fluid” includes, but is not limited to, blood, cerebrospinal fluid, urine, bile, lymph, saliva, synovial fluid, serous fluid, pleural fluid, amniotic fluid, mucus, sputum, vitreous, air, and the like, or any combination thereof. 
     As used herein, the words “proximal” and “distal” refer to the direction closer to and away from, respectively, a user who would place the device into contact with a patient. Thus, for example, the end of a device first touching the body of the patient would be the distal end, while the opposite end of the device (e.g., the end of the device being manipulated by the user) would be the proximal end of the device. 
     As described in further detail herein, any of the devices and methods can be used to procure bodily fluid samples with reduced contamination by, for example, diverting a “pre-sample” volume of bodily fluid prior to collecting a “sample” volume of bodily fluid. Each of the terms “pre-sample,” “first,” and/or “initial,” can be used interchangeably to describe and/or refer to an amount, portion, or volume of bodily fluid that is transferred, diverted, and/or sequestered prior to procuring the “sample” volume. In some embodiments, the terms “pre-sample,” “first,” and/or “initial” can refer to a predetermined, defined, desired, or given volume, portion, or amount of bodily fluid. For example, in some embodiments, a predetermined and/or desired pre-sample volume of bodily fluid can be about 0.1 milliliter (mL), about 0.2 mL, about 0.3 mL, about 0.4 mL, about 0.5 mL, about 1.0 mL, about 2.0 mL, about 3.0 mL, about 4.0 mL, about 5.0 mL, about 10.0 mL, about 20 mL, about 50 mL, and/or any volume or fraction of a volume therebetween. In other embodiments, the pre-sample volume can be greater than 50 mL or less than 0.1 mL. In some specific embodiments, a predetermined and/or desired pre-sample volume can be between about 0.1 mL and about 5.0 mL. In other embodiments, the pre-sample volume can be, for example, a drop of bodily fluid, a few drops of bodily fluid, a combined volume of any number of lumen that form, for example, a flow path (or portion thereof) from the bodily fluid source to an initial collection chamber, portion, reservoir, etc. (e.g., a sequestration chamber). 
     On the other hand, the terms “sample,” “second,” and/or “subsequent” when used in the context of a volume of bodily fluid can refer to a volume, portion, or amount of bodily fluid that is either a random volume or a predetermined or desired volume of bodily fluid collected after transferring, diverting, sequestering, and/or isolating the pre-sample volume of bodily fluid. For example, in some embodiments, a desired sample volume of bodily fluid can be about 10 mL to about 60 mL. In other embodiments, a desired sample volume of bodily fluid can be less than 10 mL or greater than 60 mL. In some embodiments, for example, a sample volume can be at least partially based on one or more tests, assays, analyses, and/or processes to be performed on the sample volume. 
     The embodiments described herein can be configured to selectively transfer bodily fluid to one or more fluid collection device(s). In some embodiments, a fluid collection device can include, but is not limited to, any suitable vessel, container, reservoir, bottle, adapter, dish, vial, syringe, device, diagnostic and/or testing machine, and/or the like. By way of specific example, in some instances, any of the embodiments and/or methods described herein can be used to transfer a sample volume into a sample reservoir such as any of those described in detail in U.S. Pat. No. 8,197,420 entitled, “Systems and Methods for Parenterally Procuring Bodily-Fluid Samples with Reduced Contamination,” filed Dec. 13, 2007 (“the &#39;420 Patent”), the disclosure of which is incorporated herein by reference in its entirety. 
     In some embodiments, a sample reservoir can be a sample or culture bottle such as, for example, an aerobic culture bottle or an anaerobic culture bottle. In this manner, the culture bottle can receive a bodily fluid sample, which can then be tested (e.g., via in vitro diagnostic (IVD) tests, and/or any other suitable test) for the presence of, for example, Gram-Positive bacteria, Gram-Negative bacteria, yeast, fungi, and/or any other organism. In some instances, the culture bottle can receive a bodily fluid sample and the culture medium (disposed therein) can be tested for the presence of any suitable organism. If such a test of the culture medium yields a positive result, the culture medium can be subsequently tested using a PCR-based system to identify a specific organism. Moreover, as described in further detail herein, in some instances, diverting a pre-sample or initial volume of bodily fluid can reduce and/or substantially eliminate contaminants in the bodily fluid sample that may otherwise lead to inaccurate test results. 
     Any of the sample containers, reservoirs, bottles, dishes, vials, etc., described herein can be devoid of contents prior to receiving a sample volume of bodily fluid or can include, for example, any suitable additive, culture medium, substances, enzymes, oils, fluids, and/or the like. For example, in some embodiments, a sample reservoir can include an aerobic or anaerobic culture medium (e.g., a nutrient rich and/or environmentally controlled medium to promote growth, and/or other suitable medium(s)), which occupies at least a portion of the inner volume defined by the sample reservoir. In some embodiments, a sample reservoir can include, for example, any suitable additive or the like such as, heparin, citrate, ethylenediaminetetraacetic acid (EDTA), oxalate, SPS, and/or the like, which similarly occupies at least a portion of the inner volume defined by the sample reservoir. In other embodiments, a sample reservoir can be any suitable container used to collect a specimen. 
     While the term “culture medium” can be used to describe a substance configured to react with organisms in a bodily fluid (e.g., microorganisms such as bacteria) and the term “additive” can be used to describe a substance configured to react with portions of the bodily fluid (e.g., constituent cells of blood, serum, synovial fluid, etc.), it should be understood that a sample reservoir can include any suitable substance, liquid, solid, powder, lyophilized compound, gas, etc. Moreover, when referring to an “additive” within a sample reservoir, it should be understood that the additive could be a culture medium, such as an aerobic culture medium and/or an anaerobic culture medium contained in a culture bottle, an additive and/or any other suitable substance or combination of substances contained in a culture bottle and/or any other suitable reservoir such as those described above. That is to say, the embodiments described herein can be used with any suitable fluid reservoir or the like containing any suitable substance. Furthermore, any of the embodiments and/or methods described herein can be used to transfer a volume of bodily fluid to a reservoir (or the like) that does not contain a culture medium, additive, and/or any other substance prior to receiving a flow of bodily fluid. 
     While some of the embodiments are described herein as being used for procuring bodily fluid for one or more culture sample testing, it should be understood that the embodiments are not limited to such a use. Any of the embodiments and/or methods described herein can be used to transfer a flow of bodily fluid to any suitable device that is placed in fluid communication therewith. Thus, while specific examples are described herein, the devices, methods, and/or concepts are not intended to be limited to such specific examples. 
     The embodiments described herein and/or portions thereof can be formed or constructed of one or more biocompatible materials. In some embodiments, the biocompatible materials can be selected based on one or more properties of the constituent material such as, for example, stiffness, toughness, durometer, bioreactivity, etc. Examples of suitable biocompatible materials include metals, glasses, ceramics, or polymers. Examples of suitable metals include pharmaceutical grade stainless steel, gold, titanium, nickel, iron, platinum, tin, chromium, copper, and/or alloys thereof. A polymer material may be biodegradable or non-biodegradable. Examples of suitable biodegradable polymers include polylactides, polyglycolides, polylactide-co-glycolides (PLGA), polyanhydrides, polyorthoesters, polyetheresters, polycaprolactones, polyesteramides, poly(butyric acid), poly(valeric acid), polyurethanes, and/or blends and copolymers thereof. Examples of non-biodegradable polymers include nylons, polyesters, polycarbonates, polyacrylates, polymers of ethylene-vinyl acetates and other acyl substituted cellulose acetates, non-degradable polyurethanes, polystyrenes, polyvinyl chloride, polyvinyl fluoride, poly(vinyl imidazole), chlorosulphonate polyolefins, polyethylene oxide, and/or blends and copolymers thereof. 
     The embodiments described herein and/or portions thereof can include components formed of one or more parts, features, structures, etc. When referring to such components it should be understood that the components can be formed by a singular part having any number of sections, regions, portions, and/or characteristics, or can be formed by multiple parts or features. For example, when referring to a structure such as a wall or chamber, the structure can be considered as a single structure with multiple portions, or multiple, distinct substructures or the like coupled to form the structure. Thus, a monolithically constructed structure can include, for example, a set of substructures. Such a set of substructures may include multiple portions that are either continuous or discontinuous from each other. A set of substructures can also be fabricated from multiple items or components that are produced separately and are later joined together (e.g., via a weld, an adhesive, or any suitable method). 
     Referring now to the drawings,  FIG.  1    is a schematic illustration of a fluid control device  100  according to an embodiment. Generally, the fluid control device  100  (also referred to herein as “control device” or “device”) is configured to withdraw bodily fluid from a patient. A first portion or amount (e.g., an initial amount) of the withdrawn bodily fluid is sequestered from a second portion or amount (e.g., a subsequent amount) of the withdrawn bodily fluid which can be subsequently used for additional testing, discarded, and/or reinfused into the patient. In this manner, contaminants or the like can be sequestered within the first portion or amount, leaving the second portion or amount substantially free of contaminants. The second portion or amount of bodily fluid can then be used as a biological sample in one or more tests for the purpose of medical diagnosis and/or treatment (e.g., a blood culture test or the like), as described in more detail herein. The first portion or amount of bodily fluid can be discarded as waste or can be used in any suitable test that is less likely to produce false, inaccurate, distorted, inconsistent, and unreliable results as a result of potential contaminants contained therein. In other instances, the first portion or amount of bodily fluid can be infused back into the patient. 
     The control device  100  includes a housing  130  that has and/or forms an inlet  131 , at least one outlet  136 , and a sequestration chamber  134 . The inlet  131  is configured to fluidically couple to a lumen-containing device, which in turn, can place the housing  130  in fluid communication with a bodily fluid source. For example, the housing  130  can be coupled to and/or can include a lumen-containing device that is in fluid communication with the inlet  131  and that is configured to be percutaneously disposed in a patient (e.g., a butterfly needle, intravenous (IV) catheter, peripherally inserted central catheter (PICC), syringe, sterile tubing, intermediary lumen-containing device, and/or bodily-fluid transfer device or the like). Thus, bodily fluid can be transferred from the patient and/or other bodily fluid source to the housing  130  via the inlet  131 , as described in further detail herein. The outlet(s)  136  can be placed in fluid communication with a fluid collection device  180  (e.g., a fluid or sample reservoir, syringe, evacuated container, etc.). As such, the control device  100  can be used and/or manipulated to selectively transfer a volume of bodily fluid from a bodily fluid source, through the inlet  131 , the housing  130 , and the outlet(s)  136  to the fluid collection device  180 , as described in further detail herein. 
     The housing  130  defines one or more fluid flow paths  133  between the inlet  131  and the sequestration chamber  134  and/or one or more fluid flow paths  154  between the inlet  131  and the outlet  136 . The housing  130  of the device  100  can be any suitable shape, size, and/or configuration. For example, in some embodiments, the housing  130  can have a size that is at least partially based on a volume of bodily fluid at least temporarily stored, for example, in the sequestration chamber  134 . As described in further detail herein, the control device  100  and/or the housing  130  can be configured to transition between operating modes such that bodily fluid flows through at least one of the fluid flow paths  133  and/or  154 . Moreover, the control device  100  and/or the housing  130  can be configured to transition automatically (e.g., based on pressure differential, time, electronically, saturation of a membrane, an absorbent and/or barrier material, etc.) or via intervention (e.g., user intervention, mechanical intervention, or the like). 
     The sequestration chamber  134  is at least temporarily placed in fluid communication with the inlet  131  via the fluid flow path(s)  133 . As described in further detail herein, the sequestration chamber  134  is configured to (1) receive a flow and/or volume of bodily fluid from the inlet  131  and (2) sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid therein. The sequestration chamber  134  can have any suitable arrangement such as, for example, those described herein with respect to specific embodiments. It should be understood, however, that the control device  100  and/or the housing  130  can have a sequestration chamber  134  in any suitable arrangement and is not intended to be limited to those shown and described herein. For example, in some embodiments, the sequestration chamber  134  can be at least partially formed by the housing  130 . In other embodiments, the sequestration chamber  134  can be a reservoir placed and/or disposed within a portion of the housing  130 . In other embodiments, the sequestration chamber  134  can be formed and/or defined by a portion of the fluid flow path  133 . That is to say, the housing  130  can define one or more lumens and/or can include one or more lumen defining device(s) configured to receive a flow of bodily fluid from the inlet  131 , thereby defining the fluid flow path  133 . In such embodiments, at least a portion of the lumen and/or a portion of the lumen defining device(s) can form and/or can define the sequestration chamber  134 . 
     The sequestration chamber  134  can have any suitable volume and/or fluid capacity. For example, in some embodiments, the sequestration chamber  134  can have a volume and/or fluid capacity between about 0.25 mL and about 5.0 mL. In some embodiments, the sequestration chamber  134  can have a volume measured in terms of an amount of bodily fluid (e.g., the initial or first amount of bodily fluid) configured to be transferred in the sequestration chamber  134 . For example, in some embodiments, the sequestration chamber  134  can have a volume sufficient to receive an initial volume of bodily fluid as small as a microliter or less of bodily fluid (e.g., a volume as small as 20 drops of bodily fluid, 10 drops of bodily fluid, 5 drops of bodily fluid, a single drop of bodily fluid, or any suitable volume therebetween). In other embodiments, the sequestration chamber  134  can have a volume sufficient to receive an initial volume of bodily fluid up to, for example, about 5.0 mL, 10.0 mL, 15 mL, 20 mL, 30 mL, 40 mL, 50 mL, or more. In some embodiments, the sequestration chamber  134  can have a volume that is equal to a fraction of and/or a multiple of at least some of the volumes of one or more lumen(s) placing the sequestration chamber  134  in fluid communication with the bodily fluid source. 
     Although not shown in  FIG.  1   , in some embodiments, the sequestration chamber  134  can include any suitable arrangement, configuration, and/or feature, and/or can be formed of one or more materials configured to interact with a portion of the bodily fluid transferred into the sequestration chamber  134 . For example, in some embodiments, the housing  130  can include an absorbent and/or hydrophilic material disposed within the sequestration chamber  134 . Accordingly, when bodily fluid is transferred into the sequestration chamber  134 , the absorbent and/or hydrophilic material can absorb, attract, retain, expand, and/or otherwise interact with at least a portion of the bodily fluid, which in turn, can sequester and/or retain at least an initial portion of the bodily fluid within the sequestration chamber  134 , as described in further detail herein. In other embodiments, the sequestration chamber  134  can include and/or can be formed of an expandable or collapsible material configured to transition between a first state (e.g., while an initial portion of the bodily fluid is being transferred into the sequestration chamber  134 ) to a second state (e.g., after the initial portion of the bodily fluid is transferred into the sequestration chamber  134 ). In some embodiments, a force associated with and/or resulting from such a material expanding or collapsing can be operable to transition the housing  130  and/or the device  100  from a first state, position, configuration, etc. to a second state, position, configuration, etc. In some embodiments, the sequestration chamber  134  and/or any other suitable portion of the housing  130  can include one or more chemicals, compounds, and/or the like configured to chemically interact with bodily fluid transferred through a portion of the housing  130 , which can be operable to transition the control device  100  and/or the housing  130  between the first state and the second state (e.g., via a force or any other suitable means). 
     In some embodiments, the control device  100  and/or the housing  130  can include and/or define a flow controller  120  configured to selectively control a flow of fluids (e.g., gas or liquids) through a portion of the control device  100 . For example, in some embodiments, the flow controller  120  can control a flow of bodily fluid through the control device  100  (or housing  130 ) and/or otherwise selectively control a flow of bodily fluid through at least one of the fluid flow paths  133  and/or  154 . The flow controller  120  can be, for example, a valve, a membrane, a diaphragm, a restrictor, a vent, a selectively permeable member (e.g., a fluid impermeable barrier or seal that at least selectively allows the passage of air or gas therethrough), a port, a junction, an actuator, and/or the like, or any suitable combination thereof. In some embodiments, the flow controller  120  can be configured to selectively control (at least in part) a flow of fluids into and/or out of the sequestration chamber  134  and/or any other suitable portion of the housing  130 . In this context, the flow of fluids, for example, can be a liquid such as water, oil, dampening fluid, bodily fluid, and/or any other suitable liquid, and/or can be a gas such as air, oxygen, carbon dioxide, helium, nitrogen, ethylene oxide, and/or any other suitable gas. For example, in some embodiments, a wall or structure of the housing  130  can define an opening, aperture, port, orifice, and/or the like that is in fluid communication with the sequestration chamber  134 . In such embodiments, the flow controller  120  can be, for example, a semi-permeable member or membrane disposed in or about the opening to selectively allow a flow of air or gas through the opening while limiting or substantially preventing a flow of fluid (e.g., bodily fluid such as blood) through the opening. 
     In some embodiments, one or more flow controllers  120  or the like can be configured to facilitate air (or other fluid) displacement through one or more portions of the control device  100 , which in some instances, can result in a pressure differential across one or more portions of the control device  100  or can result in and/or allow for a pressure equalization across one or more portions of the housing  130 . In some embodiments, the control device  100  can be configured to selectively transfer a volume of bodily fluid to the sequestration chamber  134  or to the outlet  136  based at least in part on a pressure differential between two or more portions of the control device  100 . In some embodiments, the pressure differential can result from fluidically coupling the outlet  136  to the fluid collection device  180 , which can define and/or can be configured to produce a negative pressure (e.g., an evacuated reservoir, a syringe, a pressure charged canister, and/or other source or potential energy to create a vacuum or pressure differential). In other embodiments, the pressure differential can result from a change in volume and/or temperature. In still other embodiments, the pressure differential can result from at least a portion of the control device  100 , the housing  130 , and/or other portions of the flow path being evacuated and/or charged (e.g., the sequestration chamber  134  and/or any other suitable portion). In some embodiments, the pressure differential can be established automatically or via direct or indirect intervention (e.g., by the user). 
     Moreover, a flow of a fluid (e.g., gas and/or liquid) resulting from a pressure differential can be selectively controlled via one or more flow controllers  120  that can, for example, transition between one or more operating conditions to control the fluid flow. In some embodiments, for example, the flow controller  120  can be an actuator or the like configured to transition between one or more operating conditions or states to establish fluid communication between one or more portions of the control device  100  and/or configured to sequester one or more portions of the control device  100  (e.g., the sequestration chamber  134 ). In some embodiments, the flow controller  120  can be member or device formed of an absorbent material configured to selectively allow fluid flow therethrough. For example, such an absorbent material can be transitioned from a first state in which the material allows a flow of gas (e.g., air) therethrough but prevents a flow of liquid (e.g., bodily fluid) therethrough, to a second state in which the material substantially prevents a flow of gas and liquid therethrough. In other embodiments, the flow controller  120  can include one or more valves, membranes, diaphragms, and/or the like. In some embodiments, the flow controller  120  can include any suitable combination of devices, members, and/or features. It should be understood that the flow controllers included in the embodiments described herein are presented by way of example and not limitation. Thus, while specific flow controllers are described herein, it should be understood that fluid flow can be controlled through the control device  100  by any suitable means. 
     The outlet(s)  136  is/are in fluid communication with and/or is/are configured to be placed in fluid communication with the fluid flow paths  133  and/or  154 . As shown in  FIG.  1   , the outlet  136  can be any suitable outlet, opening, port, stopcock, lock, seal, coupler, valve (e.g. one-way, check valve, duckbill valve, umbrella valve, and/or the like), etc. and is configured to be fluidically coupled to the fluid collection device  180  (e.g., a fluid reservoir, culture sample bottle, syringe, container, vial, dish, receptacle, pump, adapter, and/or any other suitable collection or transfer device). In some embodiments, the outlet  136  can be monolithically formed with the fluid collection device  180 . In other embodiments, the outlet  136  can be at least temporarily coupled to the fluid collection device  180  via an adhesive, a resistance fit, a mechanical fastener, a threaded coupling, a piercing or puncturing arrangement, any number of mating recesses, and/or any other suitable coupling or combination thereof. Similarly stated, the outlet  136  can be physically (e.g., mechanically) and/or fluidically coupled to the fluid collection device  180  such that an interior volume defined by the fluid collection device  180  is in fluid communication with the outlet  136 . In still other embodiments, the outlet  136  can be operably coupled to the fluid collection device  180  via an intervening structure (not shown in  FIG.  1   ), such as a flexible sterile tubing. In some embodiments, the arrangement of the outlet  136  can be such that the outlet  136  is physically and/or fluidically sealed prior to coupling to the fluid collection device  180 . In some embodiments, the outlet  136  can be transitioned from a sealed configuration to an unsealed configuration in response to being coupled to the fluid collection device  180  and/or in response to a negative pressure differential between an environment within the outlet  136  and/or housing  130  and an environment within the fluid collection device  180 . 
     The fluid collection device  180  can be any suitable device for at least temporarily containing a bodily fluid, such as, for example, any of those described in detail above. For example, in some embodiments, the fluid collection device  180  can be a single-use disposable collection tube(s), a syringe, a vacuum-based collection tube(s), an intermediary bodily-fluid transfer device, and/or the like. In some embodiments, the fluid collection device  180  can be substantially similar to or the same as known sample containers such as, for example, a Vacutainer® (manufactured by BD), a BacT/ALERT® SN or BacT/ALERT® FA (manufactured by Biomerieux, Inc.), and/or any suitable reservoir, vial, microvial, microliter vial, nanoliter vial, container, microcontainer, nanocontainer, and/or the like. In some embodiments, the fluid collection device  180  can be a sample reservoir that includes a vacuum seal that maintains negative pressure conditions (vacuum conditions) inside the sample reservoir, which in turn, can facilitate withdrawal of bodily fluid from the patient, through the control device  100 , and into the sample reservoir, via a vacuum or suction force, as described in further detail herein. In embodiments in which the fluid collection device  180  is an evacuated container or the like, the user can couple the fluid collection device  180  to the outlet  136  to initiate a flow of bodily fluid from the patient such that a first or initial portion of the bodily fluid is transferred into and sequestered by the sequestration chamber  134  and such that any subsequent portion or volume of bodily fluid bypasses and/or is otherwise diverted away from the sequestration chamber  134  and flows into the fluid collection device  180 , as described in further detail herein. 
     Although the outlet  136  of the control device  100  and/or the housing  130  is described above as being fluidically coupled to and/or otherwise placed in fluid communication with the fluid collection device  180 , in other embodiments, the control device  100  can be used in conjunction with any suitable bodily fluid collection device and/or system. For example, in some embodiments, the control device  100  described herein can be used in any suitable fluid transfer device such as those described in U.S. Patent Publication No. 2015/0342510 entitled, “Sterile Bodily-Fluid Collection Device and Methods,” filed Jun. 2, 2015 (referred to herein as the “&#39;510 publication”), the disclosure of which is incorporated herein by reference in its entirety. More particularly, the control device  100  can be used in an “all-in-one” or pre-assembled device (e.g., such as those described in the &#39;510 publication) to receive and sequester an initial volume of bodily fluid such that contaminants in subsequent volumes of bodily fluid are reduced and/or eliminated. 
     As described above, the device  100  can be used to procure a bodily fluid sample having reduced contamination from microbes such as, for example, dermally residing microbes, and/or the like. For example, in some instances, a user such as a doctor, physician, nurse, phlebotomist, technician, etc. can manipulate the device  100  to establish fluid communication between the inlet  131  and the bodily fluid source (e.g., a vein of a patient, cerebral spinal fluid (CSF) from the spinal cavity, urine collection, and/or the like). As a specific example, in some instances, the inlet  131  can be coupled to and/or can include a needle or the like that can be manipulated to puncture the skin of the patient and to insert at least a portion of the needle in the vein of the patient, thereby placing the inlet  131  in fluid communication with the bodily fluid source (e.g., the vein, an IV catheter, a PICC, etc.). 
     In some embodiments, once the inlet  131  is placed in fluid communication with the bodily fluid source (e.g., the portion of the patient), the outlet  136  can be fluidically coupled to the fluid collection device  180 . As described above, in some embodiments, the fluid collection device  180  can be any suitable reservoir, container, and/or device configured to receive a volume of bodily fluid. For example, the fluid collection device  180  can be an evacuated reservoir or container that defines a negative pressure and/or can be a syringe that can be manipulated to produce a negative pressure. In some instances, coupling the outlet  136  to the fluid collection device  180  selectively exposes at least a portion of the fluid flow paths  133  and/or  154  to the negative pressure, thereby resulting in a negative pressure differential operable in drawing bodily fluid from the bodily fluid source (e.g., the patient), through the inlet  131 , and into the housing  130 . 
     In some embodiments, the arrangement of the housing  130  is such that when a volume of bodily fluid is transferred to and/or through the inlet  131 , an initial portion of the volume of bodily fluid (also referred to herein as an “initial volume” or a “first volume”) flows from the inlet  131 , through at least a portion of the fluid flow path  133 , and into the sequestration chamber  134 . That is to say, in some embodiments, the control device  100  and/or the housing  130  can be in first or initial state in which the initial portion or volume of bodily fluid can flow in or through at least a portion the fluid flow path  133  and into the sequestration chamber  134 . For example, in some embodiments, the initial state of the control device  100  and/or the housing  130  can be one in which one or more flow controllers  120  (e.g., valves, membranes, diaphragms, restrictors, vents, air permeable and fluid impermeable barriers, ports, actuators, and/or the like, or a combination thereof) are in a first state in which the fluid flow path  133  is exposed to the negative pressure differential via the sequestration chamber  134 . In other words, the negative pressure within or created by the fluid collection device  180  can result in a negative pressure (or negative pressure differential) within at least a portion of the sequestration chamber  134  that is operable in drawing an initial flow of bodily fluid into the sequestration chamber  134  when one or more flow controllers  120  is/are in a first or initial state. 
     For example, in some embodiments, the flow controller  120  can be an actuator or the like that includes a valve (e.g. one-way valve, check valve, duckbill valve, umbrella valve, and/or the like), a selectively permeable member (e.g., a fluid impermeable barrier or seal that allows at least selective passage of gas or air), a selectively permeable membrane, a diaphragm, and/or the like that is at least temporarily fluidically coupled to a flow path between the fluid collection device  180  and the sequestration chamber  134  (e.g., at least a portion of the fluid flow path  154 ). While in some embodiments the flow controller  120  examples noted above can be, for example, known off-the-shelf components that are used in medical devices to control the flow of fluids and air, in other embodiments, the flow controller  120  can be a custom, proprietary, and/or specifically tailored component integrated into the device  100 . When the flow controller  120  is in the first or initial state, the flow controller  120  can allow a flow of fluid therethrough in response to the negative pressure of the fluid collection device  180 . In some embodiments, the flow controller  120  or a portion or component thereof is configured to allow only a flow of air or gas through the flow controller  120  and is configured to limit and/or substantially prevent a flow of liquid (e.g., bodily fluid) through the flow controller  120 . As such, the fluid collection device  180  can produce a negative pressure differential within the sequestration chamber  134  that is operable to draw an initial portion and/or amount of bodily fluid into the sequestration chamber  134  when the flow controller  120  is in a first or initial state without allowing the initial portion of bodily fluid to flow into the fluid flow path  154  and/or otherwise out of the sequestration chamber  134 . 
     Although not shown in  FIG.  1   , in some embodiments, the control device  100  and/or the housing  130  can include a member, device, mechanism, feature, etc. configured to modulate a magnitude of the negative pressure to which the sequestration chamber  134  is exposed. For example, in some embodiments, a housing can include a valve, a membrane, a porous material, a restrictor, an orifice, and/or any other suitable member, device, and/or feature configured to modulate pressure. In some embodiments, modulating and/or controlling a magnitude of the pressure to which the sequestration chamber  134  is exposed can, in turn, modulate a magnitude of pressure exerted on the bodily fluid and/or within a vein of a patient. In some instances, such pressure modulation can reduce, for example, hemolysis of a blood sample and/or a likelihood of collapsing a vein (e.g., which is particularly important in fragile patients needing microbial and/or other diagnostic testing associated with use of the control device  100 ). In addition, the modulation of the negative pressure can, for example, at least partially control a rate at which the control device  100  transitions between a first configuration or state and a second configuration or state. In some embodiments, modulating the negative pressure can act like a timer. For example, a time between the introduction of the negative pressure differential and the transitioning of the control device  100  from the first state to the second state can be known, predetermined, calculated, and/or controlled. As such, in some instances, modulating the negative pressure can at least partially control an amount or volume of bodily fluid transferred into the sequestration chamber  134  (i.e., can control a volume of the initial amount of bodily fluid). 
     The initial portion and/or amount of bodily fluid can be any suitable volume of bodily fluid, as described above. For example, in some instances, the control device  100  and/or the housing  130  can remain in the first state until a predetermined and/or desired volume (e.g., the initial volume) of bodily fluid is transferred to the sequestration chamber  134 . In some embodiments, the initial volume can be associated with and/or at least partially based on a volume of the sequestration chamber  134 . In other embodiments, the initial volume can be associated with and/or at least partially based on an amount or volume of bodily fluid that can be absorbed by an absorbent material, an expandable material, a hydrophilic material, a wicking material, and/or other suitable material disposed in the sequestration chamber  134 . In other embodiments, the initial volume of bodily fluid can be associated with and/or at least partially based on an amount or volume of bodily fluid that can be transferred into the sequestration chamber  134  in a predetermined time. In still other embodiments, the initial volume can be associated with and/or at least partially based on an amount or volume of bodily fluid that is sufficient to fully wet or saturate a semi-permeable member or membrane otherwise configured to selectively expose the sequestration chamber  134  to the negative pressure of the fluid collection device  180  (i.e., the flow controller  120  such as an air permeable and liquid impermeable member or membrane). In other words, in some embodiments, the initial volume of bodily fluid can be a volume sufficient to transition one or more flow controllers  120  to a second state (e.g., a saturated or fully wetted state). In still other embodiments, the control device  100  and/or the housing  130  can be configured to transfer a volume of bodily fluid (e.g., the initial volume) into the sequestration chamber  134  until a pressure differential between the sequestration chamber  134  and the fluid flow path  133  and/or the bodily fluid source is brought into substantial equilibrium and/or is otherwise reduced below a desired threshold. 
     After the initial volume of bodily fluid is transferred and/or diverted into the sequestration chamber  134 , the initial volume is sequestered, segregated, retained, contained, isolated, etc. in the sequestration chamber  134 . For example, in some embodiments, the transitioning of the one or more flow controllers  120  from a first state to a second state can be operable to sequester and/or retain the initial portion of the bodily fluid in the sequestration chamber  134 . As described in further detail herein, in some instances, contaminants such as, for example, dermally residing microbes or the like dislodged during the venipuncture event, other external sources of contamination, colonization of catheters and PICC lines that are used to collect samples, and/or the like can be entrained and/or included in the initial volume of the bodily fluid and thus, are sequestered in the sequestration chamber  134  when the initial volume is sequestered therein. 
     With the initial volume transferred and/or diverted into the sequestration chamber  134 , the device  100  can transition to the second state in which a subsequent volume(s) of bodily fluid can flow through at least a portion the fluid flow paths  133  and/or  154  from the inlet  131  to the outlet  136 . In some embodiments, the control device  100  and/or the housing  130  can passively and/or automatically transition (e.g., without user intervention) from the first state to the second state once the initial volume of bodily fluid is sequestered in the sequestration chamber  134 . For example, in some embodiments, filling the sequestration chamber  134  to capacity and/or fully saturating, wetting, and/or impregnating an absorbent or similar material disposed between the sequestration chamber  134  and the fluid collection device  180  can be such that further transfer of bodily fluid into the sequestration chamber  134  is limited and/or substantially prevented due to a removal or diversion of the negative pressure. In other embodiments, the control device  100  and/or the housing  130  can be manually transitioned or transitioned in response to at least an indirect interaction by a user. For example, in some embodiments, a user can transition the control device  100  and/or the housing  130  from the first state to the second state by actuating an actuator or the like (e.g., actuating the flow controller  120  or a portion thereof). In still other embodiments, at least a portion of the initial volume of bodily fluid can transition the control device  100  and/or the housing  130  from the first state to the second state. For example, the control device  100  can include a flow controller  120  that is and/or that includes a bodily fluid activated switch, valve, port, and/or the like. In other embodiments, a volume of bodily fluid can move and/or displace one or more flow controller  120  (e.g., actuators or the like) that can, for example, open a port, flow path, and/or outlet. In still other embodiments, a user can manipulate such a flow controller  120  (e.g., switch, valve, port, actuator, etc.) to transition the control device  100  and/or the housing  130  from the first state to the second state. 
     With the fluid collection device  180  fluidically coupled to the outlet  136  and with the control device  100  and/or the housing  130  being in the second state (e.g., the initial volume of bodily fluid is sequestered in or by the sequestration chamber  134 ), any subsequent volume(s) of the bodily fluid can flow from the inlet  131 , through at least one of the fluid flow paths  133  and/or  154 , through the outlet  136 , and into the fluid collection device  180 . Thus, as described above, sequestering the initial volume of bodily fluid in the sequestration chamber  134  prior to collecting or procuring one or more sample volumes of bodily fluid reduces and/or substantially eliminates an amount of contaminants in the one or more sample volumes. Moreover, in some embodiments, the arrangement of the control device  100  and/or the housing  130  can be such that the control device  100  and/or the housing  130  cannot transition to the second state prior to collecting and sequestering the initial volume in the sequestration chamber  134 . 
       FIGS.  2 - 5    illustrate a fluid control device  200  according to an embodiment. The fluid control device  200  can be similar in at least form and/or function to the fluid control device  100  described above with reference to  FIG.  1   . Accordingly, portions of the fluid control device  200  that can be similar to portions of the fluid control device  100  are not described in further detail herein. 
     As shown in  FIGS.  2 - 5   , the fluid control device  200  (also referred to herein as “control device” or “device”) includes a housing  230  having an inlet  231 , an outlet  236 , and an actuator  250 . As described above with reference to the control device  100 , the inlet  231  is configured to be placed in fluid communication with a bodily fluid source to receive a flow of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle, IV catheter, PICC line, or the like). The outlet  236  is configured to be fluidically coupled to a fluid collection device such as, for example, a sample reservoir, a syringe, and/or other intermediary bodily fluid transfer device or vessel (e.g., a transfer device similar to those described in the &#39;510 publication), and/or the like. 
     As described above with reference to the housing  130 , the housing  230  defines one or more fluid flow paths  233  between the inlet  231  and a sequestration chamber  234  and/or one or more fluid flow paths  254  between the inlet  231  and the outlet  236 . The housing  230  of the device  200  can be any suitable shape, size, and/or configuration. For example, in some embodiments, the housing  230  can be substantially similar in at least form and/or function to the housing  130  described above with reference to  FIG.  1   . The sequestration chamber  234  of the housing  230  is at least temporarily placed in fluid communication with the inlet  231  via the fluid flow path(s)  233 . Moreover, the sequestration chamber  234  can be selectively placed in fluid communication with the fluid flow path  254  such that at least air or gas can be transferred therebetween, as described in further detail herein. 
     As described in further detail herein, the sequestration chamber  234  is configured to (1) receive a flow and/or volume of bodily fluid from the inlet  231  and (2) sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid therein. The sequestration chamber  234  can have any suitable shape, size, and/or configuration. For example, in some embodiments, the sequestration chamber  234  can have any suitable size, volume, and/or fluid capacity such as, for example, those described above with reference to the sequestration chamber  134 . In the embodiment shown in  FIGS.  2 - 5   , the sequestration chamber  234  can be at least partially formed by the housing  230  that defines a lumen or flow path. In some embodiments, at least a portion of the fluid flow path  233  can extend through a portion of the housing  230  to form and/or define at least a portion of the sequestration chamber  234 . As shown in  FIGS.  2 - 5   , the sequestration chamber  234  and/or a portion of the fluid flow path  233  forming the sequestration chamber  234  can have a serpentine configuration or the like. In other embodiments, the sequestration chamber  234  can have any suitable arrangement. For example, in some embodiments, a housing can include a sequestration chamber that is formed by a flexible tubing or the like that can be arranged in any suitable shape and/or configuration. 
     In some embodiments, the housing  230  and/or the sequestration chamber  234  can include, form, and/or define a flow controller  242 . The flow controller  242  can be, for example, a valve, membrane, diaphragm, restrictor, vent, a selectively permeable member (e.g., a fluid impermeable barrier or seal that allows at least selective passage of gas or air such as, for example, a blood barrier and/or the like), port, etc. (collectively referred to herein as a “flow controller”) configured to selectively control (at least in part) a flow of fluids into and/or out of the sequestration chamber  234  and/or any other suitable portion of the housing  230 . More particularly, in the embodiment shown in  FIGS.  2 - 5   , the flow controller  242  is a selectively permeable fluid barrier (e.g., a blood barrier) that includes and/or is formed of a porous material configured to selectively allow a flow of gas therethrough but to prevent a flow of a liquid therethrough. 
     As shown, the flow controller  242  is positioned within the housing  230  to selectively establish fluid communication between the sequestration chamber  234  and the fluid flow path  254 . Thus, with the flow controller  242  being configured as a semi-permeable member, the flow controller  242  can be configured to at least temporarily allow a gas or air to transfer between the fluid flow path  254  and the sequestration chamber  234  and can be configured to substantially prevent a flow of liquid between the fluid flow path  254  and the sequestration chamber  234 , as described in further detail herein. 
     The outlet  236  of the housing  230  is in fluid communication with and/or is configured to be placed in fluid communication with the fluid flow paths  233  and/or  254 . As shown in  FIGS.  2 - 5   , the outlet  236  can be any suitable outlet, opening, port, lock, seal, coupler, etc. and is configured to be fluidically coupled to a fluid collection device such as a sample reservoir, a syringe, container, and/or other sample vessel. In some embodiments, the outlet  236  can be monolithically formed with the fluid collection device or can be at least temporarily coupled to the fluid collection device, as described above with reference to the outlet  136  of the housing  130 . The fluid collection device can be any suitable reservoir, container, and/or device for containing a bodily fluid, such as, for example, any of those described in detail above with reference to the fluid collection device  180 . More particularly, in some embodiments, the outlet  236  can be configured to couple to an evacuated sample reservoir. As such, the user can couple the sample reservoir to the outlet  236  to initiate a flow of bodily fluid from the patient such that a first or initial portion of the bodily fluid is transferred into and sequestered by the sequestration chamber  234  and such that any subsequent portion or volume of bodily fluid bypasses and/or is otherwise diverted away from the sequestration chamber  234  and flows into the sample reservoir. 
     As shown in  FIGS.  3 - 5   , the housing  230  includes and/or is coupled to the actuator  250  configured to selectively control a flow of bodily fluid through the housing  230 . More particularly, the actuator  250  is disposed, for example, between a portion of the fluid flow path  233  and a portion of the fluid flow path  254 . While the actuator  250  is shown in  FIGS.  3 - 5    as being positioned apart from, away from, and/or downstream of a junction between the fluid flow path  233  and the sequestration chamber  234 , in other embodiments, the actuator  250  can be disposed at any suitable position within the housing  230 . For example, in some embodiments, the actuator  250  can be positioned at and/or can form at least a portion of a junction between the fluid flow path  233 , the sequestration chamber  234 , and the fluid flow path  254 . 
     The actuator  250  can be any suitable shape, size, and/or configuration. For example, in some embodiments, the actuator  250  can be any suitable member or device configured to transition between a first state and a second state. In the embodiment shown in  FIGS.  2 - 5   , the actuator  250  is configured to isolate, sequester, separate, and/or otherwise prevent fluid communication between the fluid flow path  233  and the fluid flow path  254  when in the first state and is configured to place the fluid flow path  233  in fluid communication with the fluid flow path  254  when in the second state. In some embodiments, for example, the actuator  250  can be a valve, plunger, seal, membrane, flap, plate, and/or the like. As shown, for example, in  FIG.  5   , the actuator  250  can include one or more seals  265  configured to selectively establish fluid communication between the fluid flow channels  233  and  254  when the actuator  250  is transitioned from a first state to a second state (e.g., pressed, rotated, moved, activated, switched, slid, etc.). 
     Although the actuator  250  is particularly shown in  FIGS.  2 - 5    and described above, in other embodiments, the control device  200  can include any suitable actuator or device configured to selectively establish fluid communication between the fluid flow path  233  and  254 . Thus, while particularly shown in  FIGS.  2 - 5   , it should be understood that the control device  200  is presented by way of example only and not limitation. For example, while the actuator  250  is shown in  FIGS.  2 - 5    as being disposed in a given position, in other embodiments, the actuator  250  can be placed at any suitable position along the housing  230 . By way of example, in some embodiments, the actuator  250  can be disposed at the junction between the fluid flow path  233 , the sequestration chamber  234 , and the inlet  231 . In such embodiments, a flow of bodily fluid can flow directly from the inlet  231  and into the sequestration chamber  234  when the actuator  250  is in the first state and can flow directly from the inlet  231  to the fluid flow path  254  when the actuator  250  is in the second state. In other words, the actuator  250  can form a portion of the sequestration chamber  234  such that when the actuator  250  is in the first state, bodily fluid flows from the inlet directly into the sequestration chamber  234 . When the actuator  250  is actuated, placed, and/or transitioned to the second state, the actuator  250  can, for example, allow bodily fluid to flow directly from the inlet  231  to the fluid flow path  233 . In such embodiments, the actuator  250  can prevent the formation of a junction between the inlet  231 , the sequestration chamber  234 , and the fluid flow path  233 . Moreover, when in the second state, the actuator  250  can be operable in at least partially sequestering the sequestration chamber  234  from the inlet  231  and/or the fluid flow path  233 . 
     In addition, the actuator  250  can be actuated and/or transitioned in any suitable manner. For example, in some embodiments, the actuator  250  can transition between the first and the second state in response to a manual actuation by the user (e.g., exerting a manual force on a button, slider, switch, rotational member, etc.). In other embodiments, the actuator  250  can be configured to automatically transition between the first state and the second state in response to a pressure differential (or lack thereof), a change in potential or kinetic energy, a change in composition or configuration (e.g., a portion of the actuator could at least partially dissolve or transform), and/or the like. In still other embodiments, the actuator  250  can be mechanically and/or electrically actuated or transitioned based on a predetermined time, volumetric flow rate, flow velocity, etc. While examples of actuators and/or ways in which an actuator can transition are provided herein, it should be understood that they have been presented by way of example only and not limitation. Thus, a control device  200  can include any suitable actuator configured to transition in any suitable manner. 
     As described above, the device  200  can be used to procure a bodily fluid sample having reduced contamination from microbes such as, for example, dermally residing microbes, and/or the like. For example, in some instances, a user such as a doctor, physician, nurse, phlebotomist, technician, etc. can manipulate the device  200  to establish fluid communication between the inlet  231  and the bodily fluid source (e.g., a vein of a patient). Once the inlet  231  is placed in fluid communication with the bodily fluid source (e.g., the portion of the patient), the outlet  236  can be fluidically coupled to the fluid collection device. As described above, in the embodiment shown in  FIGS.  2 - 5   , the fluid collection device can be, for example, an evacuated reservoir or container that defines a negative pressure and/or can be any other suitable negative pressure source. 
     Coupling the outlet  236  to the fluid collection device selectively exposes at least a portion of the fluid flow path  254  to the negative pressure within the fluid collection device. As described above, the flow controller  242  is in fluid communication with the fluid flow path  254  and the sequestration chamber  234 . Thus, coupling the outlet  236  to the fluid collection device exposes the sequestration chamber to the negative pressure of the fluid collection device, thereby resulting in a negative pressure differential operable in drawing bodily fluid from the bodily fluid source (e.g., the patient), through the inlet  231 , and into the housing  230 . As described above with reference to the control device  100 , the arrangement of the housing  230  is such that when a volume of bodily fluid is transferred to and/or through the inlet  231 , an initial portion of the volume of bodily fluid (also referred to herein as an “initial volume” or a “first volume”) flows from the inlet  231 , through at least a portion of the fluid flow path  233 , and into the sequestration chamber  234 . That is to say, in some embodiments, the control device  200  and/or the housing  230  can be in first or initial state in which the initial portion or volume of bodily fluid can flow in or through at least a portion the fluid flow path  233  and into the sequestration chamber  234 . 
     As described above, the housing  230  and/or the control device  200  can be in the initial state when the flow controller  242  and the actuator  250  are in a first state, position, configuration, etc. As such, the actuator  250  isolates, separates, segregates, sequesters and/or otherwise prevents direct fluid communication between the fluid flow paths  233  and  254 . In addition, the inlet  231  is exposed to the negative pressure differential via the sequestration chamber  234 . In other words, the negative pressure within the fluid collection device can result in a negative pressure (or negative pressure differential) within at least a portion of the sequestration chamber  234  that is operable in drawing an initial flow of bodily fluid from the inlet  233  into the sequestration chamber  234  when the housing  230  and/or control device  200  is in the first or initial state. 
     When the flow controller  242  is in the first or initial state, the flow controller  242  can allow a flow of fluid (e.g., a gas or air) therethrough in response to the negative pressure of the fluid collection device (e.g., a sample reservoir, a syringe, or other source of potential energy used to create negative pressure), as described above with reference to the housing  130 . In some instances, it may be desirable to modulate and/or control a magnitude of the negative pressure differential. In the embodiment shown in  FIGS.  2 - 5   , for example, the housing  230  defines a restricted flow path  232  that places the flow controller  242  in fluid communication with the fluid flow path  254 . More specifically, the restricted flow path  232  is a fluid flow path having a smaller diameter than at least the fluid flow path  254 . 
     For example, in some embodiments, the restricted flow path  232  can have a diameter of about 0.0005″, about 0.001″, about 0.003″, about 0.005″, about 0.01″, about 0.1″, about 0.5″ or more. In other embodiments, the restricted flow path  232  can have a diameter less than 0.0005″ or greater than 0.5″. In some embodiments, the restricted flow path  232  can have a predetermined and/or desired length of about 0.01″, about 0.05″, about 0.1″, about 0.15″, about 0.2″, about 0.5″, or more. In other embodiments, the restricted flow path  232  can have a predetermined and/or desired length that is less than 0.01″ or more than about 0.5″. Moreover, in some embodiments, a restricted flow path  232  can have any suitable combination of diameter and length to allow for and/or to provide a desired flow characteristic through at least a portion of the control device  200 . 
     In this embodiment, the restricted flow path  232  having a smaller diameter results in a lower magnitude of negative pressure being applied through the sequestration chamber than a magnitude of negative pressure when the restricted flow path has a larger diameter. In some instances, modulating a magnitude of negative pressure can control a rate at which bodily fluid is transferred into the sequestration chamber  234 . For example, in some embodiments, a fluid collection device and/or other suitable negative pressure source may produce a negative pressure differential having a magnitude (e.g., a negative magnitude) of about 0.5 pounds per square inch (PSI), about 1.0 PSI, about 2.0 PSI, about 3.0 PSI, about 4.0 PSI, about 5.0 PSI, about 10 PSI, about 12.5 PSI, or about 14.7 PSI (e.g., at or substantially at atmospheric pressure at about sea level). In some embodiments, a fluid collection device such as an evacuated container or the like can have a predetermined negative pressure of about 12.0 PSI. Accordingly, by controlling the diameter and/or length of the restricted flow path  232 , the amount of negative pressure to which the sequestration chamber  234  is exposed and/or the rate at which the negative pressure is applied can be controlled, reduced, and/or otherwise modulated. In some instances, the use of the restricted flow path  232  can result in a delay or ramp up of the negative pressure exerted on or in the sequestration chamber. 
     Moreover, in this embodiment, the restricted flow path  232  is, for example, a gas flow path configured to receive a flow of gas or air but not a flow of a liquid (e.g., bodily fluid). In some embodiments, the diameter of the restricted flow path  232  can be sufficiently small to limit and/or prevent a flow of a liquid therethrough. In addition, the arrangement of the restricted flow path  232  being disposed between the fluid flow path  254  and the flow controller  242  is such that a flow of bodily fluid and/or any other liquid is substantially prevented by the flow controller  242  (e.g., a selectively permeable barrier or seal). 
     Although the pressure modulation is described above as being based on a diameter of the restricted flow path  232  (i.e., a single restricted flow path), it should be understood that this is presented by way of example only and not limitation. Other means of modulating the magnitude of negative pressure to which the sequestration chamber is exposed can include, for example, a porous material, a valve, a membrane, a diaphragm, a specific restriction, a vent, a deformable member or flow path, and/or any other suitable means. In other embodiments, a control device can include any suitable number of restricted flow paths, each of which can have substantially the same diameter or can have varied diameters. For example, in some embodiments, a control device can include up to 100 restricted flow paths or more. In such embodiments, each of the restricted flow paths can have a diameter of between about 0.0005″ and about 0.1″, between about 0.0005″ and about 0.05″, or between about 0.0005″ and about 0.01″. In some embodiments, multiple restricted flow paths can be configured to (1) selectively provide a flow path between the outlet  236  and the sequestration chamber  234  that exposes the sequestration chamber  234  to the negative pressure differential, and (2) act as a flow controller configured to selectively allow the passage of a gas and/or air while substantially preventing the passage of a liquid (e.g., bodily fluid). 
     In some embodiments, modulating and/or controlling a magnitude of the pressure to which the sequestration chamber  234  is exposed can, in turn, modulate a magnitude of pressure exerted on the bodily fluid and/or within a vein of a patient. In some instances, such pressure modulation can reduce, for example, hemolysis of a blood sample and/or a likelihood of collapsing a vein. In some instances, the ability to modulate and/or control an amount or magnitude of negative pressure can allow the control device  200  to be used across a large spectrum of patients that may have physiological challenges whereby negative pressure is often needed to facilitate collection of bodily fluid such as, for example, blood (i.e. pressure differential between atmospheric pressure and a patient&#39;s vascular pressure is not sufficient to facilitate consistent and sufficiently forceful flow) but not so much pressure that a rapid force flattens, collapses, caves-in, and/or otherwise inhibits patency and ability to collect blood. 
     The initial portion and/or amount of bodily fluid can be any suitable volume of bodily fluid, as described in detail above with reference to the control device  100 . For example, in some instances, the initial volume can be associated with and/or at least partially based on an amount or volume of bodily fluid that is sufficient to fully wet or saturate the flow controller  242 . In other words, in some embodiments, the initial volume of bodily fluid can be a volume sufficient to transition the flow controller  242  to a second state (e.g., a saturated or fully wetted state). In some embodiments, the flow controller  242  is placed in a sealed configuration when transitioned to the second state. That is to say, saturating and/or fully wetting the flow controller  242  (e.g., the semi-permeable material) places the flow controller  242  in a sealed configuration in which the flow controller  242  substantially prevents a flow of a liquid and a gas therethrough. Thus, transitioning the flow controller  242  to the second state sequesters, blocks, isolates, separates, segregates, and/or otherwise prevents flow through the flow controller  242  between the restricted flow path  232  and the sequestration chamber  234 . 
     After the initial volume of bodily fluid is transferred and/or diverted into the sequestration chamber  234 , the control device  200  and/or the housing  230  can be transitioned to its second state or operating mode to sequester, segregate, retain, contain, isolate, etc. the initial volume in the sequestration chamber  234 . For example, as described above, the flow controller  242  is placed in the sealed configuration. In addition, the actuator  250  can be actuated to transition from its first state to its second state to establish fluid communication between the fluid flow paths  233  and  254 . As such, the negative pressure otherwise exerted on or through the sequestration chamber  234  is now exerted on or through the fluid flow paths  233  and  254 . In response, bodily fluid can flow from the inlet  231 , through the fluid flow paths  233  and  254 , through the outlet  236 , and into the fluid collection device. In some embodiments, the transitioning of the flow controller  242  and the actuator  250  from their respective first states to their respective second states is operable to sequester and/or retain the initial portion of the bodily fluid in the sequestration chamber  234 . As described in further detail herein, in some instances, contaminants such as, for example, dermally residing microbes or the like dislodged during the venipuncture event, can be entrained and/or included in the initial volume of the bodily fluid and thus, are sequestered in the sequestration chamber  234  when the initial volume is sequestered therein. 
     With the fluid collection device fluidically coupled to the outlet  236  and with the control device  200  and/or the housing  230  being in the second state (e.g., the initial volume of bodily fluid is sequestered in or by the sequestration chamber  234 ), any subsequent volume(s) of the bodily fluid can flow from the inlet  231 , through the fluid flow paths  233  and  254 , through the outlet  236 , and into the fluid collection device. Thus, as described above, sequestering the initial volume of bodily fluid in the sequestration chamber  234  prior to collecting or procuring one or more sample volumes of bodily fluid reduces and/or substantially eliminates an amount of contaminants in the one or more sample volumes. Moreover, in some embodiments, the arrangement of the control device  200  and/or the housing  230  can be such that the control device  200  and/or the housing  230  cannot transition to the second state prior to collecting and sequestering the initial volume in the sequestration chamber  234 . 
     While the control device  200  is described above with reference to  FIGS.  2 - 5    as including the actuator  250  configured to be moved (e.g., via a force applied by a user) between the first state and the second state, in other embodiments, a control device can include any suitable member, device, mechanism, etc. configured to selectively establish fluid communication between two or more fluid flow paths. For example,  FIGS.  6 - 8    illustrate a fluid control device  300  according to an embodiment. The fluid control device  300  can be similar in at least form and/or function to the fluid control device  100  described above with reference to  FIG.  1    and/or the fluid control device  200  described above with reference to  FIGS.  2 - 5   . Accordingly, portions of the fluid control device  300  that can be similar to portions of the fluid control devices  100  and/or  200  are not described in further detail herein. 
     As shown in  FIGS.  6 - 8   , the fluid control device  300  (also referred to herein as “control device” or “device”) includes a housing  330  having an inlet  331  and an outlet  336 , and including or being coupled to an actuator  350 . As described above with reference to the control devices  100  and/or  200 , the inlet  331  is configured to be placed in fluid communication with a bodily fluid source to receive a flow of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle or the like). The outlet  336  is configured to be fluidically coupled to a fluid collection device (not shown in  FIGS.  6 - 8   ). 
     As described above with reference to the housings  130  and/or  230 , the housing  330  defines one or more fluid flow paths  333 ,  354 A, and  354 B configured to selectively place the inlet  331  in fluid communication with the sequestration chamber  334  and/or the outlet  336 . The housing  330  of the device  300  can be any suitable shape, size, and/or configuration. For example, in some embodiments, the housing  330  can be substantially similar in at least form and/or function to the housings  130  and/or  230  described above. In some embodiments, the housing  330  can have a size that is at least partially based on a volume of bodily fluid at least temporarily stored, for example, in the sequestration chamber  334 . The sequestration chamber  334  of the housing  330  is at least temporarily placed in fluid communication with the inlet  331  via the fluid flow path(s)  333 . Moreover, the sequestration chamber  334  can be selectively placed in fluid communication with the fluid flow path  354 A such that at least air or gas can be transferred therebetween, as described in further detail herein. 
     As described in further detail herein, the sequestration chamber  334  is configured to (1) receive a flow and/or volume of bodily fluid from the inlet  331  and (2) sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid therein. The sequestration chamber  334  can have any suitable shape, size, and/or configuration. For example, in some embodiments, the sequestration chamber  334  can be substantially similar to the sequestration chamber  234  described above with reference to  FIGS.  2 - 5    and thus, is not described in further detail herein. Likewise, the housing  330  and/or the sequestration chamber  334  include, form, and/or define a flow controller  342  that can be substantially similar to the flow controller  242  described above. As such, the flow controller  342  is positioned within the housing  330  to selectively establish fluid communication between the sequestration chamber  334  and the fluid flow path  354 A, as described in further detail herein. 
     The outlet  336  of the housing  330  is in fluid communication with and/or is configured to be placed in fluid communication with the fluid flow paths  333 ,  354 A, and/or  354 B. In addition, the outlet  336  is configured to be fluidically coupled to a fluid collection device such as, for example, a sample reservoir, container, vial, negative pressure source, syringe, and/or intermediate control and/or transfer device (not shown in  FIGS.  6 - 8   ). The outlet  336  and the fluid collection device can each be substantially similar to the outlet  236  and fluid collection device, respectively, described above with reference to the control device  200 . Thus, the outlet  336  and fluid collection device are not described in further detail herein. 
     As shown in  FIGS.  6 - 8   , the housing  330  includes and/or is coupled to the actuator  350 , which is configured to selectively control a flow of bodily fluid through the housing  330 . In some embodiments, the actuator  350  can be substantially similar in at least function to the actuator  250  described above with reference to  FIGS.  2 - 5   . In this embodiment, however, the actuator  350  is arranged as a plunger and includes a set of seals  365  disposed along an outer surface of the plunger. Moreover, the actuator  350  has a substantially annular shape and is configured to at least temporarily receive and/or otherwise be disposed about a portion of the flow controller  342 , as shown in  FIG.  8   . As described above with reference to the actuator  250 , the actuator  350  is configured to isolate, sequester, separate, and/or otherwise prevent fluid communication between the fluid flow path  333  and the fluid flow path  354 B when in the first state and is configured to place the fluid flow path  333  in fluid communication with the fluid flow path  354 B when in the second state. 
     As described above, the device  300  can be used to procure a bodily fluid sample having reduced contamination from microbes such as, for example, dermally residing microbes, and/or the like. For example, in some instances, a user such as a doctor, physician, nurse, phlebotomist, technician, etc. can manipulate the device  300  to establish fluid communication between the inlet  331  and the bodily fluid source (e.g., a vein of a patient). Once the inlet  331  is placed in fluid communication with the bodily fluid source (e.g., the portion of the patient), the outlet  336  can be fluidically coupled to the fluid collection device. As described above, in the embodiment shown in  FIGS.  6 - 8   , the fluid collection device can be, for example, an evacuated reservoir, a syringe, and/or any container that defines a negative pressure. 
     Coupling the outlet  336  to the fluid collection device selectively exposes at least a portion of the fluid flow paths  354 A and  354 B to the negative pressure within and/or produced by the fluid collection device. The arrangement of the actuator  350  when in its first state, configuration, and/or position is such that the actuator  350  isolates the fluid flow path  354 B from the fluid flow path  333  and as such, the fluid flow path  333  is not exposed to the negative pressure differential produced by the fluid collection device. As described above, the flow controller  342  is in fluid communication with the fluid flow path  354 A and the sequestration chamber  334 . More particularly, the annular arrangement of the actuator  350  allows the flow controller  342  to be in fluid communication with the fluid flow path  354 A (see e.g.,  FIG.  8   ). Thus, coupling the outlet  336  to the fluid collection device exposes the sequestration chamber  334  to the negative pressure of the fluid collection device, thereby resulting in a negative pressure differential operable in drawing bodily fluid from the bodily fluid source (e.g., the patient), through the inlet  331 , and into the housing  330 . As described above with reference to the control devices  100  and  200 , the arrangement of the housing  330  is such that when a volume of bodily fluid is transferred to and/or through the inlet  331 , an initial portion of the volume of bodily fluid (also referred to herein as an “initial volume” or a “first volume”) flows from the inlet  331  and into the sequestration chamber  334 . That is to say, in some embodiments, the housing  330  can be in first or initial state in which the initial portion or volume of bodily fluid can flow from the inlet  331  and into the sequestration chamber  334 . 
     As described above, the housing  330  and/or the control device  300  can be in the initial state when the flow controller  342  and the actuator  350  are in a first state, position, configuration, etc. As such, the actuator  350  isolates, separates, segregates, sequesters and/or otherwise prevents direct fluid communication between the fluid flow paths  333  and  354 B. In addition, the inlet  331  is exposed to the negative pressure differential via the sequestration chamber  334 . In other words, the negative pressure within or produced by the fluid collection device can result in a negative pressure (or negative pressure differential) within at least a portion of the sequestration chamber  334  that is operable in drawing an initial flow of bodily fluid from the inlet  331  into the sequestration chamber  334  when the housing  330  and/or control device  300  is in the first or initial state. As described in detail above, in some instances, it may be desirable to modulate and/or control a magnitude of the negative pressure differential by any suitable means such as those described herein. 
     The initial portion and/or amount of bodily fluid can be any suitable volume of bodily fluid, as described in detail above with reference to the control devices  100  and/or  200 . For example, in some instances, the initial volume can be associated with and/or at least partially based on an amount or volume of bodily fluid that is sufficient to fully wet or saturate the flow controller  342 . In other words, in some embodiments, the initial volume of bodily fluid can be a volume sufficient to transition the flow controller  342  to a second state (e.g., a saturated or fully wetted state). As described above with reference to the flow controller  242 , the flow controller  342  is placed in a sealed configuration when transitioned to the second state. Thus, transitioning the flow controller  342  to the second state sequesters, blocks, isolates, separates, segregates, and/or otherwise prevents flow through the flow controller  342 . 
     After the initial volume of bodily fluid is transferred and/or diverted into the sequestration chamber  334 , the control device  300  and/or the housing  330  can be transitioned to its second state or operating mode to sequester, segregate, retain, contain, isolate, etc. the initial volume in the sequestration chamber  334 . As described above, the flow controller  342  is placed in the sealed configuration and thus, substantially prevents a flow of fluid therethrough. In this embodiment, the arrangement of the actuator  350  is such that when the flow controller  342  is placed in the sealed configuration, at least a portion of the negative pressure otherwise being exerted through the flow controller  342  is instead exerted on the actuator  350 , which in turn, is sufficient to transition the actuator  350  from its first state to its second state. For example, in some embodiments, the negative pressure is operable to move the actuator  350  from a first position (e.g., the first state) to a second position (e.g., the second state), thereby establishing fluid communication between the fluid flow paths  333  and  354 B. 
     More particularly, moving the actuator  350  to its second position (or otherwise transitioning the actuator  350  to its second state), moves and/or transitions the seals  365  relative to the fluid flow paths  333  and  354 B such that fluid communication is established therebetween. As such, the negative pressure otherwise exerted on or through the sequestration chamber  334  is now exerted on or through the fluid flow paths  333  and  354 B. In response, bodily fluid can flow from the inlet  331 , through the fluid flow paths  333  and  354 B, through the outlet  336 , and into the fluid collection device. In some embodiments, the transitioning of the flow controller  342  and the actuator  350  from their respective first states to their respective second states is operable to sequester and/or retain the initial portion of the bodily fluid in the sequestration chamber  334 . As described in further detail herein, in some instances, contaminants such as, for example, dermally residing microbes or the like dislodged during the venipuncture event, can be entrained and/or included in the initial volume of the bodily fluid and thus, are sequestered in the sequestration chamber  334  when the initial volume is sequestered therein. 
     With the fluid collection device fluidically coupled to the outlet  336  and with the control device  300  and/or the housing  330  being in the second state (e.g., the initial volume of bodily fluid is sequestered in or by the sequestration chamber  334 ), any subsequent volume(s) of the bodily fluid can flow from the inlet  331 , through the fluid flow paths  333  and  354 B, through the outlet  336 , and into the fluid collection device. Thus, as described above, sequestering the initial volume of bodily fluid in the sequestration chamber  334  prior to collecting or procuring one or more sample volumes of bodily fluid reduces and/or substantially eliminates an amount of contaminants in the one or more sample volumes. Moreover, in some embodiments, the arrangement of the housing  330  can be such that housing  330  cannot transition to the second state prior to collecting and sequestering the initial volume in the sequestration chamber  334 . 
       FIGS.  9  and  10    illustrate a fluid control device  400  according to an embodiment. The fluid control device  400  can be similar in at least form and/or function to the fluid control device  100  described above with reference to  FIG.  1   , the fluid control device  200  described above with reference to  FIGS.  2 - 5   , and/or the fluid control device  300  described above with reference to  FIGS.  6 - 8   . Accordingly, portions of the fluid control device  400  that can be similar to portions of the fluid control devices  100 ,  200 , and/or  300  are not described in further detail herein. 
     As shown in  FIGS.  9  and  10   , the fluid control device  400  (also referred to herein as “control device” or “device”) includes a housing  430  having an inlet  431  and an outlet  436 , and having and/or being coupled to an actuator  450 . As described above with reference to the control devices  100 ,  200 , and/or  300 , the inlet  431  is configured to be placed in fluid communication with a bodily fluid source to receive a flow of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle or the like). The outlet  436  is configured to be fluidically coupled to a fluid collection device (not shown in  FIGS.  9  and  10   ). 
     As described above, the housing  430  of the control device  400  is configured to (1) receive a flow and/or volume of bodily fluid via the inlet  431  and (2) sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid within the sequestration chamber  434 . The housing  430  can be any suitable shape, size, and/or configuration. In some embodiments, the housing  430  can have a size that is at least partially based on a volume of bodily fluid at least temporarily stored, for example, in the sequestration chamber  434 . For example, in the embodiment shown in  FIGS.  9  and  10   , the housing  430  is arranged (at least in part) as a syringe-like device or the like, as described in further detail herein. 
     The housing  430  defines fluid flow paths  433  and  454  that are selectively in fluid communication with the outlet  436  and that selectively receive a flow of fluid therethrough (e.g., a liquid and/or a gas). The outlet  436  of the housing  430  is in fluid communication with and/or is configured to be placed in fluid communication with the fluid flow paths  433  and/or  454 . In addition, the outlet  436  is configured to be fluidically coupled to a fluid collection device (not shown in  FIGS.  9  and  10   ). The outlet  436  and the fluid collection device can each be substantially similar to the outlet  236  and fluid collection device, respectively, described above with reference to the control device  200 . Thus, the outlet  436  and fluid collection device are not described in further detail herein. 
     The housing  430  includes and/or is coupled to the actuator  450  configured to selectively control a flow of bodily fluid through the housing  430 . In this embodiment, the actuator  450  includes a first plunger  460  and a second plunger  461  movably disposed within the housing  430  and configured to at least partially define the sequestration chamber  434 . More specifically, the actuator  450  is configured to move between a first state in which the inlet  431  is placed in fluid communication with the sequestration chamber  434  ( FIG.  9   ) and a second state in which the inlet  431  is placed in fluid communication with the outlet  436  via the fluid flow path  454  ( FIG.  10   ). In this embodiment, when the actuator  450  and/or housing  430  is in the first state, the inlet  431  is in fluid communication with a portion of the housing  430  defined between the first plunger  460  and the second plunger  461 . 
     When in the first state, the first plunger  460  is disposed in a position such that a dampening chamber  437  is defined by the housing  430  on a side of the first plunger  460  opposite the sequestration chamber  434 . As shown, the dampening chamber  437  is configured to be placed in fluid communication with the fluid flow path  433  via a port  435 . The port  435  can be an opening, a valve, a membrane, a diaphragm, and/or any other suitable flow controller or the like configured to at least selectively establish fluid communication between the fluid flow path  433  and the dampening chamber  437 . Furthermore, when the actuator  450  and/or the housing  430  is in the first state, the dampening chamber  437  includes and/or contains a dampening fluid  456  such as a gas (compressed or uncompressed) and/or a liquid (e.g., water, oil, dampening fluid, and/or any other suitable liquid). 
     When the actuator  450  and/or housing  430  are in the first state, the second plunger  461  is disposed in a position within the housing  430  such that one or more seals  465  formed by or coupled to the second plunger  461  fluidically isolate, separate, and/or sequester the inlet  431  from the fluid flow path  454 . In addition, the second plunger  461  and/or the seals  465  formed by or coupled thereto fluidically isolate the fluid flow path  454  from the sequestration chamber  434 . Thus, when the actuator  450  and/or control device  400  are in the first state, the inlet  431  is in fluid communication with the sequestration chamber  434  and is fluidically isolated from the fluid flow paths  433  and  454  as well as the outlet  436  (see  FIG.  9   ). As described in further detail herein, the actuator  450  and/or the control device  400  can be configured to transition to the second state in which the sequestration chamber  434  is sequestered within the housing  430  and the inlet  431  is placed in fluid communication with the fluid flow path  454  (see  FIG.  10   ). 
     As described above, the device  400  can be used to procure a bodily fluid sample having reduced contamination from microbes such as, for example, dermally residing microbes, and/or the like. For example, in some instances, a user such as a doctor, physician, nurse, phlebotomist, technician, etc. can manipulate the device  400  to establish fluid communication between the inlet  431  and the bodily fluid source (e.g., a vein of a patient). Once the inlet  431  is placed in fluid communication with the bodily fluid source (e.g., the portion of the patient), the outlet  436  can be fluidically coupled to the fluid collection device. As described above, in the embodiment shown in  FIGS.  9  and  10    the fluid collection device can be, for example, an evacuated reservoir or container that defines a negative pressure. 
     As shown in  FIG.  9   , the actuator  450  and/or the control device  400  can be in a first or initial state prior to coupling the outlet  436  to the fluid collection device. Thus, the fluid flow path  433  is in fluid communication with the dampening chamber  437  and the fluid flow path  454  is fluidically isolated from the inlet  431  and the sequestration chamber  434  (e.g., via the second plunger  461 ). As described above, coupling the outlet  436  to the fluid collection device exposes at least a portion of the fluid flow paths  433  and  454  to the negative pressure within the fluid collection device. When the actuator  450  and/or the control device  400  are in the first state, the second plunger  461  isolates the housing  430  and/or the sequestration chamber  434  from the negative pressure exerted via the fluid flow path  454 . Conversely, the negative pressure exerted through the fluid flow path  433  can be operable in exerting at least a portion of the negative pressure on the dampening chamber  437  (e.g., via the port  435 ). In some embodiments, for example, the port  435  can be transitioned from a closed configuration to an open configuration in response to the negative pressure. 
     The negative pressure exerted through the fluid flow path  433  is operable in transitioning the actuator  450  from a first state to a second state. For example, in some embodiments, the negative pressure differential draws the dampening fluid  456  from the dampening chamber  437  and into the fluid flow path  433  or a secondary chamber or the like. Moreover, the negative pressure urges the first plunger  460  to transition and/or move relative to the housing  430  from a first configuration or position to a second configuration or position. In some embodiments, the transitioning and/or moving of the first plunger  460  can be such that a volume of the housing  430  defined between the first plunger  460  and the second plunger  461  is increased (i.e., a volume of the sequestration chamber  434  is increased). In some embodiments, the increase in the volume of the sequestration chamber  434  results in a negative pressure therein, which in turn, can be operable in drawing an initial volume of bodily fluid through the inlet  431  and into the sequestration chamber  434 . In other words, the negative pressure of the fluid collection device indirectly results in a negative pressure differential between the inlet  431  and the sequestration chamber  434  that is operable in drawing the initial volume of bodily fluid into the sequestration chamber  434 . 
     As shown in  FIG.  10   , movement of the first plunger  460  results in a similar movement of the second plunger  461 . For example, in some embodiments, the arrangement of the actuator  450  is such that after the first plunger  460  has moved a predetermined amount (and/or after the volume of the sequestration chamber  434  has been increased a predetermined amount) and an initial volume of bodily fluid has been drawn into the sequestration chamber  434 , the second plunger  461  is moved or transitioned from a first position and/or configuration to a second position and/or configuration. As such, the actuator  450  is placed in its second state in which the sequestration chamber  434  is sequestered from the inlet  431 . In addition, the second plunger  461  and/or the seals  465  coupled thereto place the inlet  431  in fluid communication with the fluid flow path  454 . Thus, the negative pressure otherwise exerted on or through the fluid flow path  433  is now exerted on or through the fluid flow path  454 . In response, bodily fluid can flow from the inlet  431 , through the fluid flow path  454 , through the outlet  436 , and into the fluid collection device. 
     In some embodiments, the transitioning of the actuator  450  from the first state to the second state is operable to sequester and/or retain the initial portion of the bodily fluid in the sequestration chamber  434 . As described in further detail herein, in some instances, contaminants such as, for example, dermally residing microbes or the like dislodged during the venipuncture event, can be entrained and/or included in the initial volume of the bodily fluid and thus, are sequestered in the sequestration chamber  434  when the initial volume is sequestered therein. Thus, as described above, sequestering the initial volume of bodily fluid in the sequestration chamber  434  prior to collecting or procuring one or more sample volumes of bodily fluid reduces and/or substantially eliminates an amount of contaminants in the one or more sample volumes. Moreover, in some embodiments, the arrangement of the housing  430  can be such that housing  430  cannot transition to the second state prior to collecting and sequestering the initial volume in the sequestration chamber  434 . 
     As described above with reference to the control devices  100 ,  200 , and/or  300 , the control device  400  is configured to modulate an amount of negative pressure exerted on the first plunger  460  when the actuator  450  is in the first state. Specifically, in this embodiment, the dampening fluid  456  disposed in the dampening chamber  437  reduces a magnitude of the negative pressure exerted on the first plunger  460 . As such, the rate at which the actuator  450  and/or control device  400  is transitioned from the first state to the second state can be controlled. Moreover, in some instances, exposing the housing  430  to the full magnitude of the negative pressure may result transitioning the actuator  450  and/or the control device  400  from the first state to the second state prior to receiving the initial volume of bodily fluid in the sequestration chamber  434 . Thus, modulating the magnitude of the pressure can ensure a desired volume of bodily fluid is transferred into the sequestration chamber  434 . Although shown in  FIGS.  9  and  10    as modulating the negative pressure via the dampening fluid  456 , it should be understood that this is presented by way of example only and not limitation. Any other suitable means of dampening and/or modulating a magnitude of the negative pressure can be used to control the transitioning of the actuator  450  and/or housing  430 . 
     Although the housing  430  is shown in  FIGS.  9  and  10    and described above as including the plungers  460  and  461  and being in a syringe-like configuration, in other embodiments, a housing can include any other suitable means for controlling fluid flow therethrough. For example,  FIGS.  11  and  12    illustrate a fluid control device  500  according to an embodiment. The fluid control device  500  can be similar in at least form and/or function to any of the fluid control devices  100 ,  200 ,  300 , and/or  400 . Accordingly, portions of the fluid control device  500  that can be similar to portions of the fluid control devices  100 ,  200 ,  300 , and/or  400  are not described in further detail herein. As shown in  FIGS.  11  and  12   , the fluid control device  500  (also referred to herein as “control device” or “device”) includes a housing  530  having an inlet  531  and an outlet  536 , and having and/or being coupled to an actuator  550 . As described above with reference to the control devices  100 ,  200 ,  300 , and/or  400 , the inlet  531  is configured to be placed in fluid communication with a bodily fluid source to receive a fluid of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle or the like). The outlet  536  is configured to be fluidically coupled to a fluid collection device (not shown in  FIGS.  11  and  12   ). The inlet  531 , the outlet  536 , and the fluid collection device can be substantially similar to those described above and thus, are not described in further detail herein. 
     As described above, the housing  530  of the control device  500  is configured to (1) receive a flow and/or volume of bodily fluid via the inlet  531  and (2) sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid within the sequestration chamber  534 . The housing  530  can be any suitable shape, size, and/or configuration. In some embodiments, the housing  530  can have a size that is at least partially based on a volume of bodily fluid at least temporarily stored, for example, in the sequestration chamber  534 . For example, in the embodiment shown in  FIGS.  11  and  12   , the housing  530  can be arranged in a substantially similar manner as the housing  430  described above with reference to  FIGS.  9  and  10   . As described in further detail herein, the housing  530  can differ from the housing  430 , by arranging the actuator  550  as, for example, a diaphragm rather than one or more plungers. 
     The housing  530  defines a set of fluid flow paths  533  and  554  in fluid communication with the outlet  536  and configured to selectively receive a flow of fluid therethrough (e.g., a liquid and/or a gas). The housing  530  includes and/or is coupled to the actuator  550  configured to selectively control a flow of bodily fluid through the housing  530 . In this embodiment, the actuator  550  includes a diaphragm  576  movably disposed within the housing  530  and configured to at least partially define the sequestration chamber  534 . More specifically, the actuator  550  is configured to move between a first state in which the inlet  531  is placed in fluid communication with the sequestration chamber  534  ( FIG.  11   ) and a second state in which the inlet  531  is placed in fluid communication with the outlet  536  via the fluid flow path  554  ( FIG.  12   ). 
     As shown in  FIG.  11   , when the actuator  550  and/or control device  500  is in the first state, the inlet  531  is in fluid communication with a portion of the housing  530  defined between the diaphragm  576  and one or more seals  565 . Moreover, the diaphragm  576  is disposed in a first state such that a dampening chamber  537  is defined by the housing  530  on a side of the diaphragm  576  opposite the sequestration chamber  534 , as described above with reference to the housing  430 . As shown, the dampening chamber  537  is configured to be placed in fluid communication with the fluid flow path  533  via a port  535 . The port  535  can be an opening, a valve, a membrane, a diaphragm, and/or any other suitable flow controller or the like configured to at least selectively establish fluid communication between the fluid flow path  533  and the dampening chamber  537 . Furthermore, when the actuator  550  and/or the control device  500  is in the first state, the dampening chamber  537  includes and/or contains a dampening fluid such as a gas (compressed or uncompressed) and/or a liquid (e.g., water, oil, dampening fluid, and/or any other suitable liquid). As described above with reference to the control devices  400 , the arrangement of the dampening chamber  537 , the dampening fluid, and the port  535  can be configured to modulate an amount of negative pressure exerted on the diaphragm  576  when the actuator  550  is in the first state. Although shown in  FIGS.  11  and  12    as modulating the negative pressure via the dampening fluid, it should be understood that this is presented by way of example only and not limitation. Any other suitable means of dampening and/or modulating a magnitude of the negative pressure can be used to control the transitioning of the actuator  550  and/or the control device  500 . 
     As described above with reference to the actuator  450 , when the actuator  550  and/or the control device  500  are in the first state, the one or more seals  565  are disposed in a position within the housing  530  such that the one or more seals  565  fluidically isolate, separate, and/or sequester the inlet  531  from the fluid flow path  554 . In addition, the one or more seals  565  fluidically isolate the fluid flow path  554  from the sequestration chamber  534 . Thus, when the actuator  550  and/or the control device  500  are in the first state, the inlet  531  is in fluid communication with the sequestration chamber  534  and fluidically isolated from the fluid flow paths  533  and  554  as well as the outlet  536  (see  FIG.  11   ). As described in further detail herein, the actuator  550  and/or the control device  500  housing  530  can be configured to transition to the second state in which the sequestration chamber  534  is sequestered within the housing  530  and the inlet  531  is placed in fluid communication with the fluid flow path  554  (see  FIG.  12   ). 
     As described in detail above, the device  500  can be used to procure a bodily fluid sample having reduced contamination from microbes such as, for example, dermally residing microbes, and/or the like. For example, in some instances, a user can place the inlet  531  in fluid communication with the bodily fluid source (e.g., the portion of the patient) and can fluidically couple the outlet  536  to the fluid collection device. As shown in  FIG.  11   , the actuator  550  and/or the device  500  can be in a first or initial state prior to coupling the outlet  536  to the fluid collection device. Thus, the fluid flow path  533  is in fluid communication with the dampening chamber  537  and the fluid flow path  554  is fluidically isolated from the inlet  531  and the sequestration chamber  534  (e.g., via the one or more seals  565 ), as described in detail above with reference to the control device  400  of  FIGS.  9  and  10   . 
     Coupling the outlet  536  to the fluid collection device selectively exposes at least a portion of the fluid flow paths  533  and  554  to the negative pressure within and/or produced by the fluid collection device. When the actuator  550  and/or the device  500  are in the first state, the one or more seals  565  isolate the housing  530  and/or the sequestration chamber  534  from the negative pressure exerted via the fluid flow path  554 . Conversely, the negative pressure exerted through the fluid flow path  533  can be operable in exerting at least a portion of the negative pressure on the dampening chamber  537  (e.g., via the port  535 ). In some embodiments, for example, the port  535  can be transitioned from a closed configuration to an open configuration in response to the negative pressure. The negative pressure exerted through the fluid flow path  533  is operable in transitioning the actuator  550  from a first state to a second state. For example, in some embodiments, the negative pressure differential draws the dampening fluid from the dampening chamber  537  and into the fluid flow path  533 . Moreover, the negative pressure urges the diaphragm  576  to transition, flip, move, switch, deform, etc., from a first configuration or state ( FIG.  11   ) to a second configuration or state ( FIG.  12   ). As described above with reference to the actuator  450 , the transitioning of the diaphragm  576  from the first state to the second state can be such that a volume of the housing  530  defined between the diaphragm  576  and the one or more seals  565  is increased (i.e., a volume of the sequestration chamber  534  is increased), which in turn, results in a negative pressure therein that can be operable in drawing an initial volume of bodily fluid through the inlet  531  and into the sequestration chamber  534 . 
     As shown in  FIG.  12   , movement of the diaphragm  576  results in a similar movement of the one or more seals  565  such that the one or more seals  565  are disposed on the same side of the inlet  531  as the diaphragm  576 . Thus, the sequestration chamber  534  is sequestered within the housing  530 . In addition, moving the one or more seals  565  is such that fluid communication is established between the inlet  531  and the fluid flow path  554 . Thus, the negative pressure otherwise exerted on or through the fluid flow path  533  is now exerted on or through the fluid flow path  554 . In response, bodily fluid can flow from the inlet  531 , through the fluid flow path  554 , through the outlet  536 , and into the fluid collection device, as described in detail above. In some embodiments, the transitioning of the actuator  550  from the first state to the second state is operable to sequester and/or retain the initial portion of the bodily fluid in the sequestration chamber  534 , which can include contaminants such as, for example, dermally residing microbes or the like dislodged during the venipuncture event. Thus, as described above, sequestering the initial volume of bodily fluid in the sequestration chamber  534  prior to collecting or procuring one or more sample volumes of bodily fluid reduces and/or substantially eliminates an amount of contaminants in the one or more sample volumes. Moreover, in some embodiments, the arrangement of the control device  500  and/or the housing  530  can be such that the control device  500  and/or the housing  530  cannot transition to the second state prior to collecting and sequestering the initial volume in the sequestration chamber  534 . 
       FIGS.  13 - 15    illustrate a fluid control device  600  according to an embodiment. The fluid control device  600  can be similar in at least form and/or function to any of the fluid control devices  100 ,  200 ,  300 ,  400 , and/or  500 . Accordingly, portions of the fluid control device  600  that can be similar to portions of the fluid control devices  100 ,  200 ,  300 ,  400 , and/or  500  are not described in further detail herein. As shown in  FIGS.  13 - 15   , the fluid control device  600  (also referred to herein as “control device” or “device”) includes a housing  630  having an inlet  631  and an outlet  636 , and having and/or being coupled to an actuator  650 . As described above with reference to the control devices  100 ,  200 ,  300 ,  500 , and/or  500 , the inlet  631  is configured to be placed in fluid communication with a bodily fluid source to receive a fluid of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle or the like). The outlet  636  is configured to be fluidically coupled to a fluid collection device (not shown in  FIGS.  13 - 15   ). The inlet  631 , the outlet  636 , and the fluid collection device can be substantially similar to those described above and thus, are not described in further detail herein. 
     As described above, the housing  630  of the control device  600  is configured to (1) receive a flow and/or volume of bodily fluid via the inlet  631  and (2) sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid within a sequestration chamber  634  included in and/or at least partially formed by the housing  630 . The housing  630  can be any suitable shape, size, and/or configuration. In some embodiments, the housing  630  can have a size that is at least partially based on a volume of bodily fluid at least temporarily stored, for example, in the sequestration chamber  634 . For example, in the embodiment shown in  FIGS.  13 - 15   , the housing  630  can be arranged in a substantially similar manner as the housing  530  described above with reference to  FIGS.  11  and  12   . That is to say, the housing  630  includes an actuator  650  that is arranged as a diaphragm. 
     The housing  630  defines a set of fluid flow paths  633  and  654  in fluid communication with the outlet  636  and configured to selectively receive a flow of fluid therethrough (e.g., a liquid and/or a gas). The housing  630  includes and/or is coupled to the actuator  650  configured to selectively control a flow of bodily fluid through the housing  630 . In this embodiment, the actuator  650  includes a diaphragm  676  movably disposed within the housing  630  and configured to at least partially define the sequestration chamber  634 . More specifically, the actuator  650  is configured to move between a first state in which the inlet  631  is placed in fluid communication with the sequestration chamber  634  and a second state in which the inlet  631  is placed in fluid communication with the outlet  636  via the fluid flow path  654 , as described in detail above with reference to the control device  500 . 
     As shown in  FIGS.  14  and  15   , when the actuator  650  and/or the device  600  is in the first state, the inlet  631  is in fluid communication with a portion of the housing  630  defined between the diaphragm  676  and one or more seals  665 . Moreover, the diaphragm  676  is disposed in a first state such that a dampening chamber  637  is defined by the housing  630  on a side of the diaphragm  676  opposite the sequestration chamber  634 , as described above with reference to the housing  530 . As shown, the dampening chamber  637  is configured to be placed in fluid communication with the fluid flow path  654  via a port  635  (such as those described above). Although not shown, when the actuator  650  and/or the device  600  is in the first state, the dampening chamber  637  includes and/or contains a dampening fluid such as a gas (compressed or uncompressed) and/or a liquid (e.g., water, oil, dampening fluid, and/or any other suitable liquid), that can be configured to modulate an amount of negative pressure exerted on the diaphragm, as described in detail above with reference to the control device  500 . Although described as modulating the negative pressure via the dampening fluid, it should be understood that this is presented by way of example only and not limitation. Any other suitable means of dampening and/or modulating a magnitude of the negative pressure can be used to control the transitioning of the actuator  650  and/or device  600 . 
     As described above with reference to the actuator  550 , when the actuator  650  and/or the device  600  are in the first state, the seal  665  is disposed in a position within the housing  630  such that the seal  665  fluidically isolates, separates, and/or sequesters the inlet  631  from the fluid flow path  654 . In addition, the seal  665  fluidically isolates the fluid flow path  654  from the sequestration chamber  634 . Thus, when the actuator  650  and/or the device  600  are in the first state, the inlet  631  is in fluid communication with the sequestration chamber  634  and fluidically isolated from the fluid flow path  654  as well as the outlet  636 . The actuator  650  and/or the device  600  can be configured to transition to the second state in which the sequestration chamber  634  is sequestered within the housing  630  and the inlet  631  is placed in fluid communication with the fluid flow path  654 . Accordingly, the device  600  can be used to procure a bodily fluid sample having reduced contamination from microbes (e.g., dermally residing microbes and/or the like), in a substantially similar manner as the device  500  described above with reference to  FIGS.  11  and  12   . Thus, the functioning of the device  600  is not described in further detail herein. 
       FIGS.  16 - 18    illustrate a fluid control device  700  according to an embodiment. The fluid control device  700  can be similar in at least form and/or function to any of the fluid control devices  100 ,  200 ,  300 ,  400 ,  500 , and/or  600 . Accordingly, portions of the fluid control device  700  that can be similar to portions of the fluid control devices  100 ,  200 ,  300 ,  400 ,  500 , and/or  600  are not described in further detail herein. As shown in  FIGS.  16 - 18   , the fluid control device  700  (also referred to herein as “control device” or “device”) includes a housing  730  having an inlet  731  and an outlet  736 , and having or being coupled to an actuator  750 . As described above with reference to the control devices  100 ,  200 ,  300 ,  400 ,  500 , and/or  600 , the inlet  731  is configured to be placed in fluid communication with a bodily fluid source to receive a fluid of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle or the like). The outlet  736  is configured to be fluidically coupled to a fluid collection device (not shown in  FIGS.  16 - 18   ). The inlet  731 , the outlet  736 , and the fluid collection device can be substantially similar to those described above and thus, are not described in further detail herein. 
     As described above, the housing  730  of the control device  700  is configured to (1) receive a flow and/or volume of bodily fluid via the inlet  731  and (2) sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid within the sequestration chamber  734 . The housing  730  can be any suitable shape, size, and/or configuration. In some embodiments, the housing  730  can have a size that is at least partially based on a volume of bodily fluid at least temporarily stored, for example, in the sequestration chamber  734 . For example, in the embodiment shown in  FIGS.  16 - 18   , the housing  730  can be arranged in a substantially similar manner as the housings  530  and/or  630 . That is to say, the housing  530  includes and/or is coupled to the actuator  750  that is arranged as a diaphragm. 
     The housing  730  defines a set of fluid flow paths  733  and  754  in fluid communication with the outlet  736  (see e.g.,  FIGS.  17 A and  17 B ) and configured to selectively receive a flow of fluid therethrough (e.g., a liquid and/or a gas). The housing  730  includes and/or is coupled to the actuator  750  configured to selectively control a flow of bodily fluid through the housing  730 . In this embodiment, the actuator  750  includes a diaphragm  776  movably disposed within the housing  730  and configured to at least partially define the sequestration chamber  734 . More specifically, the actuator  750  is configured to move between a first state in which the inlet  731  is placed in fluid communication with the sequestration chamber  734  and a second state in which the inlet  731  is placed in fluid communication with the outlet  736  via the fluid flow path  754 , as described in detail above with reference to the control device  500 . 
     In the embodiment shown in  FIGS.  16 - 18   , when the actuator  750  and/or the device  700  are in the first state, the inlet  731  is in fluid communication with the sequestration chamber  734  formed by a portion of the housing  730  defined between the diaphragm  776  and a flow controller  742  (e.g., a selectively permeable fluid barrier or seal, and/or any other flow controller such as any of those described above). Moreover, the diaphragm  776  is disposed in a first state such that the fluid flow path  733  is in fluid communication with the sequestration chamber  734 . As described above with reference to the actuator  550 , when in the actuator  750  and/or device  700  are in the first state, the diaphragm  776  and/or the seal  765  are disposed in a position within the housing  730  such that the diaphragm  776  and/or the seal  765  fluidically isolate, separate, and/or sequester the inlet  731  from the fluid flow path  754 . In addition, the diaphragm  776  and/or the seal  765  fluidically isolate the fluid flow path  754  from the sequestration chamber  734 . Thus, when the actuator  750  and/or the device  700  are in the first state, the inlet  731  is in fluid communication with the sequestration chamber  734  and fluidically isolated from the fluid flow path  754 . 
     As described above with reference to, for example, the control device  200 , when the actuator  750  and/or the device  700  are in the first state, a negative pressure differential within the sequestration chamber  734  can result from the coupling of the fluid collection device to the outlet  736 . More specifically, the fluid flow path  733  can be in fluid communication with the outlet  736  and the flow controller  742 . When the flow controller  742  is in a first state, the flow controller  742  can allow a gas or air to pass therethrough. Thus, the negative pressure differential within the sequestration chamber  734  can result from the coupling of the fluid collection device to the outlet  736 . 
     As shown in  FIG.  18   , the actuator  750  and/or the device  700  can be configured to transition to the second state in which the sequestration chamber  734  is sequestered within the housing  730  and the inlet  731  is placed in fluid communication with the fluid flow path  754 , as described in detail above with reference to the control device  600 . More particularly, an initial volume of bodily fluid can be transferred into the sequestration chamber  734 , which in turn, can saturate, can wet, and/or otherwise can transition the flow controller  742  from the first or open state to a second or closed state. In some embodiments, the transitioning of the flow controller  742  from the first state to the second state is operable in isolating the fluid flow path  733  from the outlet  736 . As such, a negative pressure exerted through the fluid flow path  754  can be operable in transitioning, switching, flipping, moving, deforming, and/or otherwise reconfiguring the diaphragm  776  such that the actuator  750  is placed in its second state. As such, the negative pressure of the fluid collection device can draw bodily fluid from the inlet  731 , through the housing  730  (bypassing the sequestration chamber  734 ), through the fluid flow path  754  and the outlet  736 , and into the fluid collection device, as described in detail above. Accordingly, the device  700  can be used to procure a bodily fluid sample having reduced contamination from microbes (e.g., dermally residing microbes and/or the like), in a manner substantially similar to one or more of the control devices  100 ,  200 ,  300 ,  400 ,  500 , and/or  600  described in detail above. Thus, the functioning of the device  700  is not described in further detail herein. 
     In some embodiments, any of the control devices  100 ,  200 ,  300 ,  400 ,  500 ,  600 , and/or  700  can be formed from any suitable components that can be manufactured, assembled, sterilized, and packaged as an assembly or integrated device. In such embodiments, a user can, for example, open a packaging containing such an assembly or integrated device and can use the device as described above with reference to the control devices  100 ,  200 ,  300 ,  400 ,  500 ,  600 , and/or  700 . In some embodiments, any of the control devices can be monolithically formed in whole or at least in part. 
     In some embodiments any of the control devices can be physically coupled, attached, formed, and/or otherwise mated to a fluid collection device (e.g., a sample reservoir, a syringe, a blood culture bottle, a collection vial, a fluid transfer container, and/or any other suitable reservoir, collection device, and/or transfer device) during a manufacturing process. This can be done prior to sterilization so the collection pathway(s) and connection interface(s) (e.g., where the control device couples to the fluid collection device) maintain a closed-system, mechanical diversion device within a sterile environment that is not subject to touch-point contamination from external sources. In this manner, in order for a user to transfer a sample volume to the fluid collection device, the user would be forced first to sequester, segregate, and/or isolate at least a portion of the initial bodily fluid volume or flow. In some embodiments, the coupling, mating, and/or attachment of the fluid control device to the fluid collection device can be executed such that the control device can be removed (physically decoupled, removed with a specific “key,” and/or any other approach used to separate the control device from the fluid collection device) after use to allow access to the fluid collection device, which can then be placed in an incubator and/or any other type of analytical machine, and accessed for analysis and/or otherwise further processed. In some embodiments, such decoupling may be blocked, limited, and/or substantially prevented prior to use and unblocked or allowed after use. In other embodiments, the fluid control device and the fluid collection device can be permanently coupled and/or monolithically formed (at least in part) to prevent such decoupling. 
     While described above as being coupled and/or assembled, for example, during manufacturing, in other embodiments, however, a control device can include one or more modular components that can be selected by a user based on a desired use, preference, patient, etc. In such embodiments, the user can couple one or more modular components (packaged together or packaged separately) to form the desired fluid control device. For example,  FIGS.  19 - 25    illustrate a modular fluid control device  800  according to an embodiment. The fluid control device  800  can be similar in at least form and/or function to the fluid control devices described herein. More specifically, portions of the fluid control device  800  can be similar to and/or substantially the same as corresponding portions of the fluid control device  200  described above with reference to  FIGS.  2 - 5   . Accordingly, such portions of the fluid control device  800  are not described in further detail herein. 
     The fluid control device  800  (also referred to herein as “control device” or “device”) includes a housing  830  and an actuator  850 . As described above, the control device  800  can be at least partially monolithically formed or can be otherwise preassembled during manufacturing. In other embodiments, the control device  800  can be at least partially modular such that a user can physically and fluidically couple the housing  830  and the actuator  850  to form the control device  800 . The housing  830  of the device  800  can be any suitable shape, size, and/or configuration. For example, in the embodiment shown in  FIGS.  19 - 25   , the housing  830  can be, for example, relatively thin and substantially rectangular. In some embodiments, portions of the housing  830  can be substantially similar in at least form and/or function to the housing  230  described above with reference to  FIGS.  2 - 5   . Thus, while such portions are identified, similar components, features, and/or functions are not described in further detail herein. 
     As shown in  FIGS.  19  and  20   , the housing  830  forms and/or defines a sequestration chamber  834  that is in selective fluid communication with a first port  845  and a second port  846 . The first port  845  and the second port  846  are configured to be at least fluidically coupled to a portion of the actuator  850  to allow for selective fluid flow between the housing  830  and the actuator  850 . As described in further detail herein, the sequestration chamber  834  is configured (1) to receive a selective flow and/or volume of bodily fluid from a portion of the actuator  850  via the first port  845 , and (2) to sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid (e.g., an initial or first flow and/or volume of bodily fluid or any portion thereof) within the sequestration chamber  834 . The sequestration chamber  834  can have any suitable shape, size, and/or configuration. For example, in some embodiments, the sequestration chamber  834  can have any suitable size, volume, and/or fluid capacity such as, for example, those described above with reference to the sequestration chamber  134 . In the embodiment shown in  FIGS.  19 - 25   , the sequestration chamber  834  can be, for example, a fluid flow path that extends through and/or that is defined by at least a portion of the housing  830 . In some embodiments, the sequestration chamber  834  can be substantially similar in at least form and/or function to the sequestration chamber  234  described above with reference to  FIGS.  2 - 5    and thus, is not described in further detail herein. 
     As shown in  FIG.  20   , the housing  830  includes and/or defines a flow controller  842  and a restricted flow path  832 . The flow controller  842  can be, for example, a valve, membrane, diaphragm, restrictor, vent, a selectively permeable member, port, etc. configured to selectively control (at least in part) a flow of fluids into and/or out of the sequestration chamber  834  and/or any other suitable portion of the housing  830 . For example, the flow controller  842  can be a selectively permeable fluid barrier (e.g., a blood barrier) that includes and/or is formed of a porous material configured to selectively allow a flow of gas therethrough but to prevent a flow of a liquid therethrough. In some embodiments, the flow controller  842  can be substantially similar to the flow controller  242  described in detail above with reference to  FIGS.  2 - 5    and thus, is not described in further detail herein. 
     As shown, the restricted flow path  832  defined by the housing  830  is in fluid communication with the second port  846  and is positioned between the second port  846  and the flow controller  842  (or a portion of the housing  830  receiving or housing the flow controller  842 ). As described above with reference to the restricted flow path  232  shown in  FIGS.  2 - 5   , the restricted flow path  832  is a fluid flow path having a smaller diameter than, for example, one or more other flow paths defined by the housing  830  and/or actuator  850 . For example, in some embodiments, the restricted flow path  832  can have a diameter between about 0.0005″ to about 0.5″ and can have a length between about 0.01″ and about 0.5″, as described above with reference to the restricted flow path  232 . As described above, the smaller diameter of the restricted flow path  832  results in a lower magnitude of negative pressure being applied through the sequestration chamber  834  than a magnitude of negative pressure when the restricted flow path  832  has a larger diameter. In other words, the restricted flow path  832  can be configured to modulate an amount of negative pressure to which the sequestration chamber  834  is exposed. In some instances, modulating the amount of negative pressure can control a rate at which bodily fluid is transferred into the sequestration chamber  834 . Moreover, in this embodiment, the restricted flow path  832  is, for example, a gas flow path configured to receive a flow of gas or air but not a flow of a liquid (e.g., bodily fluid), which can allow for a negative pressure differential sufficient to successfully collect the initial volume of bodily fluid and/or sufficient to transition at least a portion of the control device  800  to a second state, while limiting and/or substantially preventing a portion of the initial or first volume of bodily fluid from being drawn through the sequestration chamber  834  and the second port  846 . 
     As shown in  FIGS.  19 - 24   , the actuator  850  includes a body  851  and an actuator rod  862 . The body  851  of the actuator  850  includes an inlet  852  and an outlet  853 . The inlet  852  and the outlet  853  can be substantially similar in at least form and/or function to the inlet  231  and the outlet  236 , respectively, described above with reference to  FIGS.  2 - 5   . Thus, the inlet  852  is configured to be placed in fluid communication with a bodily fluid source to receive a flow of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle, IV catheter, PICC line, or the like). The outlet  853  is configured to be fluidically coupled to a fluid collection device  880  such as, for example, a sample reservoir, a syringe, and/or other intermediary bodily fluid transfer device, adapter, or vessel (see e.g.,  FIG.  25   ) such as, for example, a transfer device similar to those described in the &#39;510 publication. 
     As shown in  FIG.  21   , the body  851  of the actuator  850  includes and/or defines a first port  858  and a second port  859 . The first port  858  is in fluid communication with the inlet  852  and the second port  859  is in fluid communication with the outlet  853 . In addition, the first port  858  and the second port  859  are configured to be at least fluidically coupled to the first port  845  and the second port  846 , respectively, of the housing  830 . As described in further detail herein, the actuator  850  can be transitioned between a first operating mode or state and a second operating mode or state to selectively control fluid flow through the ports  858  and  859  of the actuator  850  and the ports  845  and  846  of the housing  830 , which in turn, can selectively control a flow of bodily fluid into and/or out of the sequestration chamber  834  of the housing  830 . 
     In some embodiments, the arrangement of the ports  858  and  859  of the actuator  850  and the ports  845  and  846  of the housing  830  can allow for and/or otherwise can provide a means of physically coupling the housing  830  to the actuator  850  as well as fluidically coupling the housing  830  to the actuator  850 . For example, in some embodiments, the ports  858  and  859  of the actuator  850  and the ports  845  and  846  of the housing  830  can form a friction fit, a press fit, an interference fit, and/or the like. In other embodiments, the ports  858  and  859  of the actuator  850  can be coupled to the ports  845  and  846 , respectively, of the housing  830  via an adhesive, a mechanical fastener, an elastomeric coupling, a gasket, an o-ring(s), and/or any other suitable coupling means. In still other embodiments, the ports  858  and  859  of the actuator  850  can be physically and fluidically coupled to the ports  845  and  846 , respectively, of the housing  830  via an intervening structure such as, for example, one or more sterile, flexible tubing(s). As such, the device  800  can be and/or can have, for example, a modular configuration in which the housing  830  can be at least fluidically coupled to the actuator  850 . 
     In some embodiments, such a modular arrangement can allow a user to select a housing (or actuator) with one or more desired characteristics based on, for example, the intended purpose and/or use of the assembled device. In other embodiments, the modular arrangement can allow and/or facilitate one or more components with desired characteristics to be coupled and/or assembled during manufacturing. For example, in some instances, it may be desirable to select a housing that includes and/or defines a sequestration chamber having a particular or desired volume. As a specific example, when the device is being used to procure bodily fluid from a pediatric patient and/or a very sick patient (for example), it may be desirable to select a housing that defines and/or includes a sequestration chamber with a smaller volume than may otherwise be selected when the device is being used to procure bodily fluid from a seemingly healthy adult patient. Accordingly, such a modular arrangement can allow a user (e.g., a doctor, physician, nurse, technician, phlebotomist, etc.) to select a housing or an actuator having one or more desired characteristics based on, for example, the intended use of the device. In other instances, the modular arrangement can allow or facilitate assembly of a housing or an actuator having one or more desired characteristics during manufacturing without making significant changes to one or more manufacturing processes. 
     The actuator rod  862  of the actuator  850  is movably disposed within a portion of the body  851 . The actuator rod  862  includes a first end portion  863  and a second end portion  864 , at least one of which extends beyond the body  851  of the actuator  850  with the actuator rod  862  is disposed within the body  851  (see e.g.,  FIGS.  23  and  24   ). A portion of the actuator rod  862  includes and/or is coupled to a set of seals  865 . The seals  865  can be, for example, o-rings, elastomeric over-molds, proud or raised dimensions or fittings, and/or the like. The arrangement of the actuator  862  and the body  851  of the actuator  850  can be such that an inner portion of the seals  865  forms a fluid tight seal with a surface of the actuator rod  862  and an outer portion of the seals  865  forms a fluid tight seal with an inner surface of the body  851 . In other words, the seals  865  form one or more fluid tight seals between the actuator rod  862  and the inner surface of the body  851 . As shown in  FIGS.  23  and  24   , the actuator rod  862  includes and/or is coupled to three seals  865  which form and/or define a first fluid flow path  833  within the body  851  of the actuator  850  and a second fluid flow path  854  within the body  851  of the actuator  850 . 
     The actuator rod  862  is configured to be moved or transitioned relative to the body  851  between a first position or configuration and a second position or configuration. For example, in some instances, a force can be exerted on the first end portion  863  of the actuator rod  862  to place the actuator rod  862  in its first position and/or configuration, as shown in  FIG.  23   . The force exerted on the first end portion  863  of the actuator rod  862  can come from any suitable source. For example, a user can create the force with his or her hand or finger, a syringe, a positive or negative pressure source, and/or any other external energy source. When in the first position and/or configuration, the inlet  852  of the actuator  850  is in fluid communication with the first fluid flow path  833  and the outlet  853  of the actuator  850  is in fluid communication with the second fluid flow path  854 . In some instances, a force can be exerted on the second end portion  864  of the actuator rod  862  to place the actuator rod  862  in its second position and/or configuration, as shown in  FIG.  24   . When in the second position and/or configuration, the inlet  852  and the outlet  853  of the actuator  850  are each in fluid communication with the second fluid flow path  854  while the first fluid flow path is sequestered, isolated, and/or otherwise not in fluid communication with the inlet  852  and the outlet  853 . Although not shown, the first port  858  of the actuator  850  is in fluid communication with the first fluid flow path  833  and the second port  859  of the actuator  850  is in fluid communication with the second fluid flow path  854 . As such, moving and/or transitioning the actuator rod  862  (or the actuator  850  in general) between the first position and the second position can be operable in selectively controlling a flow of fluid (e.g., bodily fluid) between the inlet  852  of the actuator  850  and the housing  830 , or between the inlet  852  of the actuator  850  and the outlet  853  of the actuator  850 , as described in further detail herein. 
     As described above, the device  800  can be used to procure a bodily fluid sample having reduced contamination from microbes such as, for example, dermally residing microbes, microbes external to the bodily fluid source, and/or the like. For example, in some instances, a user such as a doctor, physician, nurse, phlebotomist, technician, etc. can manipulate the device  800  to establish fluid communication between the inlet  852  and the bodily fluid source (e.g., a vein of a patient). Once the inlet  852  is placed in fluid communication with the bodily fluid source (e.g., the portion of the patient), the outlet  853  can be fluidically coupled to the fluid collection device  880 . In the embodiment shown in  FIGS.  19 - 25   , the fluid collection device  880  can be, for example, a syringe (as shown in  FIG.  25   ), and/or any other suitable container or device configured to define or produce a negative pressure or energy source. 
     As described in detail above with reference to, for example, the device  200 , coupling the outlet  853  to the fluid collection device  880  selectively exposes at least a portion of the control device  800  to a negative pressure within and/or produced by the fluid collection device  880 . More specifically, in the embodiment shown in  FIGS.  19 - 25   , coupling the outlet  853  to the fluid collection device  880  exposes the outlet  853  of the actuator  850  and the second fluid flow path  854  to the negative pressure within and/or produced by the fluid collection device  880 . In addition, the second port  859  of the actuator  850  is in fluid communication with the second fluid flow path  854  and the second port  846  of the housing  830 . The second port  846  of the housing  830 , in turn, is in selective fluid communication with the sequestration chamber  834  via the flow controller  842  and the restricted flow path  832 . For example, the device  800  and/or the flow controller  842  can be in a first operating state or mode in which the flow controller  842  allows a flow of gas (e.g., air) through the flow controller  842  while limiting and/or preventing a flow of liquid (e.g., bodily fluid such as blood) through the flow controller  842 . Thus, coupling the fluid collection device  880  to the outlet  853  results in a negative pressure differential between the fluid collection device  880  (and/or any suitable negative pressure source) and the sequestration chamber  834 . 
     As described above, the control device  800  can be in a first or initial state when the flow controller  842  and/or the actuator  850  are in a first state, position, configuration, etc. As such, the actuator rod  862  can be in its first position and/or configuration in which the first fluid flow path  833  is in fluid communication with the inlet  852 . In addition, the first port  858  of the actuator  850  and the first port  845  of the housing  830  establish fluid communication between the sequestration chamber  834  and the first fluid flow path  833 . Thus, the negative pressure within the fluid collection device  880  can result in a negative pressure (or negative pressure differential) within at least a portion of the sequestration chamber  834  that is operable in drawing an initial flow, portion, amount, or volume of bodily fluid from the inlet  852 , through the first fluid flow path  833 , and into the sequestration chamber  834  when the actuator  850  and/or control device  800  is in the first or initial state (e.g., when the actuator rod  862  is in its first state, position, and/or configuration). In some instances, the arrangement of the flow controller  842  and/or the restricted flow path  832  can be configured to restrict, limit, control, and/or otherwise modulate an amount or magnitude of negative pressure exerted on or through the sequestration chamber  834 , as described in detail above with reference to the device  200 . 
     The initial portion and/or amount of bodily fluid can be any suitable volume of bodily fluid, as described in detail above with reference to the control device  100 . For example, in some instances, the initial volume can be associated with and/or at least partially based on an amount or volume of bodily fluid that is sufficient to fully wet or saturate the flow controller  842 . In other words, in some embodiments, the initial volume of bodily fluid can be a volume sufficient to transition the flow controller  842  from a first state to a second state (e.g., a saturated or fully wetted state). In some embodiments, the flow controller  842  is placed in a sealed configuration when transitioned to the second state. That is to say, saturating and/or fully wetting the flow controller  842  (e.g., the semi-permeable material) places the flow controller  842  in a sealed configuration in which the flow controller  842  substantially prevents a flow of a liquid and a gas therethrough. Thus, transitioning the flow controller  842  to the second state sequesters, blocks, isolates, separates, segregates, and/or otherwise prevents flow through the flow controller  842  between the restricted flow path  832  and the sequestration chamber  834 . 
     After the initial volume of bodily fluid is transferred and/or diverted into the sequestration chamber  834 , the control device  800  and/or the actuator  850  can be transitioned to its second state or operating mode to sequester, segregate, retain, contain, isolate, etc. the initial volume in the sequestration chamber  834 . For example, the actuator  850  can be actuated to transition from its first state to its second state, for example, by exerting a force on the second end portion  864  of the actuator rod  862 . As such, the actuator rod  862  is moved and/or transitioned to its second state, position, and/or configuration in which the first fluid flow path  833  is sequestered and/or isolated from the inlet  852 . With the flow controller  842  in the sealed configuration in response to the initial volume of bodily fluid being disposed in the sequestration chamber  834  and with the initial fluid flow path  833  sequestered and/or isolated from the inlet  852 , the initial volume of bodily fluid is sequestered in the sequestration chamber  834 . As described in detail above, in some instances, contaminants such as, for example, dermally residing microbes or the like dislodged during the venipuncture event, can be entrained and/or included in the initial volume of the bodily fluid and thus, are sequestered in the sequestration chamber  834  when the initial volume is sequestered therein. 
     As shown in  FIG.  24   , moving and/or transitioning the control device  800  and/or the actuator  850  to its second state or configuration establishes fluid communication between the inlet  852  and the outlet  853  via the second fluid flow path  854 . As such, the negative pressure otherwise exerted on or through the sequestration chamber  834  is now exerted on or through the fluid flow path  854 . In response, bodily fluid can flow from the inlet  852 , through the fluid flow path  854 , through the outlet  853 , and into the fluid collection device  880 . Thus, as described above, sequestering the initial volume of bodily fluid in the sequestration chamber  834  prior to collecting or procuring one or more sample volumes of bodily fluid reduces and/or substantially eliminates an amount of contaminants in the one or more sample volumes. Moreover, in some embodiments, the arrangement of the control device  800  can be such that the control device  800  cannot transition to the second state prior to collecting and sequestering the initial volume in the sequestration chamber  834 , thereby reducing the likelihood of contaminants being transferred to the fluid collection device  880 . 
     In some instances, it may be desirable to isolate the negative pressure source (e.g., the fluid collection device  880  from the inlet  853  such as, for example, if it is desirable to collect multiple samples of bodily fluid using multiple fluid collection device  880  (e.g., syringes). For example, in some instances, after filling the fluid collection device  880  the user can engage the actuator  850  and exert a force on the first end portion  863  of the actuator rod  862  to move and/or transition the actuator rod  862  from its second position and/or configuration toward its first position and/or configuration. As such, the second fluid flow path  854  no longer places the inlet  852  in fluid communication with the outlet  853 . Moreover, the flow controller  842  can remain in the sealed state or configuration (e.g., fully saturated, wetted, and/or otherwise preventing flow therethrough) such that the outlet  853  is substantially sequestered or isolated from the rest of the control device  800 . In some instances, the user can then remove the filled fluid collection device  880  (e.g., syringe) and can couple a new fluid collection device  880  (e.g., syringe) to the outlet  853 . With the new fluid collection device  880  coupled to the outlet  853 , the user can, for example, exert a force on the second end portion  864  of the actuator rod  862  to move and/or transition the actuator rod  862  back to its second position, state, and/or configuration, as described above. 
     While the fluid collection device  880  coupled to the device  800  is shown in  FIG.  25    as being a syringe, in other embodiments, a control device can be physically and/or fluidically coupled to any suitable collection device. For example,  FIG.  26    illustrates a fluid control device  900 . As described above with reference to the control device  800 , the fluid control device  900  includes a housing  930  and an actuator  950 , which can be arranged, for example, in a modular configuration or the like. The actuator  950  includes an inlet  952  configured to be placed in fluid communication with a bodily fluid source and an outlet  953  configured to be coupled to a fluid collection device  980 . In the embodiment shown in  FIG.  26   , the fluid collection device  980  is a transfer adapter configured to be coupled to one or more reservoirs such as, for example, an evacuated container, a sample bottle, a culture bottle, etc. In such embodiments, the reservoir can be sealed prior to being coupled to the transfer adapter (i.e., the fluid collection device  980 ) and once coupled the seal can be punctured, displaced, deformed, and/or otherwise unsealed to expose the outlet  953  to the negative pressure within the reservoir. Thus, the fluid control device  900  can function in a substantially similar manner to the control device  800  described above with reference to  FIGS.  19 - 25   . 
     While the fluid control device  800  is shown as including the actuator rod  862  that includes the first end portion  863  and the second portion  864  on which a force can be exerted to transition the device  800  between its first and second configurations, states, and/or positions, in other embodiments, a control device can include an actuator having any suitable configuration. For example, the fluid control device  900  includes an actuator rod  962  having only a single end portion that extends beyond the body  951  of the actuator  950 , as shown in  FIG.  26   . In such embodiments, the device  900  can be used to fill a fluid collection device such as, for example, a sample reservoir, container, bottle, etc. and if it is desirable for more than one sample to be collected, the user can, for example, decouple the inlet  952  from a lumen-containing device and/or any suitable device otherwise placing the inlet  952  in fluid communication with the bodily fluid source. Once decoupled, the user can couple the inlet of a new control device  900  to the lumen-containing device and/or the like and can collect one or more additional samples in a manner similar to that described above with reference to the control device  800 . 
     As described above, some fluid control device described herein can be and/or can have a modular configuration in which one or more components can be coupled to collectively form a fluid control device having a desired set of characteristics or the like. For example, the fluid control device  800  shown in  FIGS.  19 - 25    includes the housing  830  and the actuator  850  in one modular arrangement. It should be understood, however, that a control device can have any suitable modular arrangement. For example,  FIG.  27    illustrates a modular fluid control device  1000  according to an embodiment. The fluid control device (also referred to herein as “device”) includes a housing  1030  forming and/or defining a sequestration chamber  1034 , and an actuator  1050  forming and/or having an inlet  1052  and an outlet  1053 . The device  1000  can be substantially similar to the control device  800  described in detail above but can be arranged such that housing  1030  is disposed in different position and/or orientation relative to the actuator  1050 . In some embodiments, varying the arrangement may, for example, enhance usability, visibility, and/or the like and/or may otherwise allow for a more compact design. 
     As another example,  FIG.  28    illustrates a modular fluid control device  1100  according to an embodiment. The fluid control device (also referred to herein as “device”) includes a housing  1130  forming and/or defining a sequestration chamber  1134 , and an actuator  1150  forming and/or having an inlet  1152  and an outlet  1153 . The device  1100  can be substantially similar to the control device  800  described in detail above but can be arranged such that housing  1130  is disposed in different position and/or orientation relative to the actuator  1150 . Moreover, as shown in  FIG.  28   , the actuator  1150  can be arranged such that the inlet  1152  and the outlet  1153  are disposed in substantially perpendicular positions relative to one another. As described above, in some embodiments, varying the arrangement may, for example, enhance usability, visibility, and/or the like and/or may otherwise allow for a more compact design. While examples of modular fluid control devices are shown herein, it should be understood that such embodiments are presented by way of example and not limitation. Thus, while specific arrangements and/or orientations may be described herein, the devices and/or concepts described herein are not intended to be limited to those shown herein. 
     While the housings  230 ,  330 ,  830 ,  930 ,  1030 , and  1130  have been shown and described herein as including and/or defining a sequestration chamber that is arranged in a serpentine-like configuration, in other embodiments, a housing and/or any other suitable portion of a control device can include and/or can define a sequestration chamber having any suitable configuration. For example,  FIGS.  29 - 34    illustrate a fluid control device  1200  according to an embodiment. The fluid control device  1200  can be similar in at least form and/or function to the fluid control devices described herein. More specifically, portions of the fluid control device  1200  can be similar to and/or substantially the same as corresponding portions of the fluid control devices  200 ,  300 ,  800 ,  900 ,  1000 , and/or  1100  described above. Accordingly, such portions of the fluid control device  1200  are not described in further detail herein. 
     The fluid control device  1200  (also referred to herein as “control device” or “device”) includes a housing  1230  and an actuator  1250 . As described above with reference to the control device  800 , the control device  1200  can be arranged in a modular configuration such that the housing  1230  and the actuator  1250  can be physically and fluidically coupled to form the control device  1200 . In other embodiments, the control device  1200  need not be modular. That is to say, in some embodiments, the control device  1200  can be assembled during manufacturing and delivered to a supplier and/or end user as an assembled device. In other embodiments, the control device can be monolithically formed and/or coupled to a fluid collection device in any suitable manner, as described in detail above. 
     The housing  1230  of the control device  1200  can be any suitable shape, size, and/or configuration. For example, in some embodiments, the housing  1230  can be substantially similar in at least form and/or function to the housing  830  described in detail above. Accordingly, such similar portions of the housing  1230  are identified below but may not be described in further detail herein. 
     As shown in  FIGS.  29 - 31   , the housing  1230  forms and/or defines a sequestration chamber  1234  that is in selective fluid communication with a first port  1245  and a second port  1246 . The second port  1246  is configured to receive, include, and/or define a flow controller  1242  (see e.g.,  FIG.  30   ) and a restricted flow path  1232  (see e.g.,  FIG.  31   ). Although shown as including the restricted flow path  1232 , in other embodiments, a housing need not include or receive a restricted flow path (e.g., when excessive negative pressure being applied to the sequestration chamber  1234  is unlikely or otherwise not intended such as when a fluid collection device is a syringe or the like). The first port  1245  and the second port  1246  are configured to be at least fluidically coupled to a portion of the actuator  1250  to allow for selective fluid flow between the housing  1230  and the actuator  1250 . As described in further detail herein, the sequestration chamber  1234  is configured (1) to receive a selective flow and/or volume of bodily fluid from a portion of the actuator  1250  via the first port  1245 , and (2) to sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid (e.g., an initial or first flow and/or volume of bodily fluid or any portion thereof) within the sequestration chamber  1234 . 
     The sequestration chamber  1234  can have any suitable shape, size, and/or configuration. For example, in some embodiments, the sequestration chamber  1234  can have any suitable size, volume, and/or fluid capacity such as, for example, those described above with reference to the sequestration chamber  134 . In the embodiment shown in  FIGS.  29 - 34   , the sequestration chamber  1234  can be, for example, a fluid flow path that extends through and/or that is defined by at least a portion of the housing  1230 . In some embodiments, the sequestration chamber  1234  can be substantially similar in at least form and/or function to the sequestration chamber  834  described above with reference to  FIGS.  19 - 25   . The sequestration chamber  1234  and/or the housing  1230  can differ from the sequestration chamber  834  and/or the housing  830  by being arranged in a spiral configuration with the first port  1245  being in fluid communication with, for example, an inner portion of the spiraled sequestration chamber  1234  and the second port  1246  being in fluid communication with, for example, an outer portion of the spiraled sequestration chamber, as shown in  FIG.  30   . In some embodiments, the sequestration chamber  1234  can be, for example, a channel or the like formed in a portion of the housing  1230 . 
     In some embodiments, the channel forming at least a portion of the sequestration chamber  1234  can have a relatively small cross-sectional shape and/or size that can reduce and/or substantially prevent a mixing of an initial volume of bodily fluid drawn into the sequestration chamber  1234  (channel) and a volume of air within the sequestration chamber  1234  (e.g., a volume of air that has not been vented or purged, as described in further detail herein). For example, in some instances, the relatively small cross-sectional shape and/or size of the sequestration chamber  1234  (channel), a surface tension associated with the bodily fluid flowing into the sequestration chamber  1234 , and a contact angle between a surface of the housing  1230  forming the sequestration chamber  1234  and the bodily fluid flowing into the sequestration chamber  1234  can collectively limit and/or substantially prevent a mixing of the bodily fluid and a volume of air within the sequestration chamber  1234 . 
     As shown in  FIG.  30   , the housing  1230  can include and/or can be coupled to a cover  1238  configured to enclose the channel, thereby forming the sequestration chamber  1234 . The cover  1238  can be coupled to the housing  1230  in any suitable manner (e.g., via a friction fit, snap fit, interference fit, an adhesive, one or more mechanical fasteners, laser welding, ultrasonic welding, plasma techniques, annealing, heat boding and/or any other suitable coupling means or combination thereof). In other embodiments, the cover  1238  is monolithically formed with and/or coupled to the housing  1230 . Moreover, in some embodiments, the cover  1238  can be at least partially transparent to allow a user to visualize a flow of bodily fluid through the sequestration chamber  1234 . In some embodiments, the arrangement of the housing  1230  and the cover  1238  can, for example, facilitate one or more manufacturing processes and/or can facilitate use of the control device  1200 . 
     As shown in  FIG.  30   , the housing  1230  includes and/or defines a flow controller  1242  and a restricted flow path  1232 . The flow controller  1242  can be, for example, a valve, membrane, diaphragm, restrictor, vent, a selectively permeable member, port, etc. configured to selectively control (at least in part) a flow of fluids into and/or out of the sequestration chamber  1234  and/or any other suitable portion of the housing  1230 . For example, the flow controller  1242  can be a selectively permeable fluid barrier (e.g., a blood barrier) that includes and/or is formed of a porous material configured to selectively allow a flow of gas therethrough but to prevent a flow of a liquid therethrough. As such, the flow controller  1242  can be configured to vent and/or purge a volume of air within the sequestration chamber  1234  through the flow controller  1242  in response to a negative pressure differential within a portion of the control device  1200 . Such a venting and/or purging of the volume of air within the sequestration chamber  1234  can result in a suction force and/or negative pressure differential being exerted and/or applied in or on the sequestration chamber  1234  that is operable to draw in the initial volume of bodily fluid. Moreover, the use of a selectively permeable fluid barrier can allow for the venting and/or purging of air without allowing a volume of bodily fluid to pass through the flow controller  1242 . Accordingly, in some embodiments, the flow controller  1242  can be substantially similar to the flow controller  242  described in detail above with reference to  FIGS.  2 - 5    and thus, is not described in further detail herein. 
     The actuator  1250  of the control device  1200  can be any suitable shape, size, and/or configuration. For example, in some embodiments, the actuator  1250  can be substantially similar in at least form and/or function to the actuator  850  described in detail above. Accordingly, such similar portions of the actuator  1250  are identified below but may not be described in further detail herein. 
     As shown in  FIGS.  32 - 34   , the actuator  1250  includes a body  1251  and an actuator rod  1262 . The body  1251  of the actuator  1250  includes an inlet  1252  and an outlet  1253 . The inlet  1252  and the outlet  1253  can be substantially similar in at least form and/or function to the inlet  852  and the outlet  853 , respectively, described above with reference to  FIGS.  19 - 25   . Thus, the inlet  1252  is configured to be placed in fluid communication with a bodily fluid source to receive a flow of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle, IV catheter, PICC line, or the like). The outlet  1253  is configured to be fluidically coupled to a fluid collection device (not shown in  FIGS.  29 - 34   ) such as, for example, a sample reservoir, a syringe, and/or other intermediary bodily fluid transfer device, adapter, or vessel such as, for example, a transfer device similar to those described in the &#39;510 publication. In some embodiments, such a transfer device can provide a negative pressure and/or can act as an external energy source to enable desired functionality and fluid flow path dynamics/characteristics of the control device  1200 . 
     The body  1251  of the actuator  1250  includes and/or defines a first port  1258  and a second port  1259 . The first port  1258  is in fluid communication with the inlet  1252  and the second port  1259  is in fluid communication with the outlet  1252 . In addition, the first port  1258  and the second port  1259  are configured to be at least fluidically coupled to the first port  1245  and the second port  1246 , respectively, of the housing  1230 . In some embodiments, the arrangement of the ports  1258  and  1259  of the actuator  1250  and the ports  1245  and  1246  of the housing  1230  can allow for and/or otherwise can provide a means of physically coupling the housing  1230  to the actuator  1250  as well as fluidically coupling the housing  1230  to the actuator  1250 . That is to say, in some embodiments, the arrangement of the ports  1258  and  1259  of the actuator  1250  and the ports  1245  and  1246  of the housing  1230  can allow for a modular configuration or arrangement as described above with reference to the control device  800 . In other embodiments, the housing  1230  and/or actuator  1250  need not be modular. 
     In some embodiments, the body  1251  and the actuator rod  1262  collectively include and/or collectively form a lock configured to at least temporarily lock the actuator  1250 . For example, in some embodiments, the body  1251  and the actuator rod  1262  can each define an opening  1257  in or through which a locking member can be disposed. In such embodiments, when the locking member (not shown in  FIG.  32   ) is disposed in the openings  1257 , the locking member can limit and/or substantially prevent the actuator rod  1262  from being moved relative to the body  1251 . On the other hand, removing the locking member from the openings  1257  can allow the actuator rod  1262  to be moved relative to the body  1251 . While described as forming a lock, in some embodiments, the body  1251  and the actuator rod  1262  collectively include and/or collectively form a feature and/or arrangement that can limit and/or substantially prevent the actuator rod  1262  from being pulled out of the body  1251 . In such embodiments, the feature can be a snap, a lock, a catch, and/or any other suitable feature and/or arrangement. 
     As shown in  FIGS.  33  and  34   , a portion of the actuator rod  1262  includes and/or is coupled to a set of seals  1265 . The seals  1265  can be, for example, o-rings, over-molded elastomeric material, raised protrusions, and/or the like. The arrangement of the actuator  1262  and the body  1251  of the actuator  1250  can be such that the seals  1265  form one or more fluid tight seals between the actuator rod  1262  and the inner surface of the body  1251 , as described above with reference to the actuator  850 . In the embodiment shown in  FIGS.  33  and  34   , the actuator rod  1262  includes and/or is coupled to three seals  1265  which form and/or define a first fluid flow path  1233  within the body  1251  of the actuator  1250  and a second fluid flow path  1254  within the body  1251  of the actuator  1250 . In other embodiments, any number of seals may be used to achieve desired performance. 
     As described above with reference to the device  800 , the device  1200  can be used to procure a bodily fluid sample having reduced contamination from microbes such as, for example, dermally residing microbes, microbes external to the bodily fluid source, and/or the like. For example, the actuator rod  1262  is configured to be moved or transitioned relative to the body  1251  between a first position or configuration and a second position or configuration. In some embodiments, the transition of the actuator rod  1262  can be achieved by and/or can otherwise result from user interaction and manipulation of the actuator rod  1262 , automatically in response to negative pressure and associated flow dynamics within the device  1200 , and/or enacted by or in response to an external energy source which creates dynamics that result in the transitioning of the actuator rod  1262 . As shown in  FIG.  33   , when in the first position and/or configuration, the inlet  1252  of the actuator  1250  is in fluid communication with the first fluid flow path  1233 , which in turn, is in fluid communication with the first port  1258 . The outlet  1253  of the actuator  1250  is in fluid communication with the second fluid flow path  1254 , which in turn, is in fluid communication with the second port  1259 . Thus, when in the actuator  1250  and/or actuator rod  1262  is in the first position and/or configuration (e.g., when the control device  1200  is in a first state or operating mode), the negative pressure within the fluid collection device (not shown in  FIGS.  29 - 34   ) can result in a negative pressure (or negative pressure differential) within at least a portion of the sequestration chamber  1234  that is operable in drawing at least a portion of an initial flow, amount, or volume of bodily fluid from the inlet  1252 , through the first fluid flow path  1233 , and into the sequestration chamber  1234 . Moreover, in some instances, the initial volume and/or flow of bodily fluid can be transferred into the sequestration chamber  1234  until, for example, the bodily fluid disposed within the sequestration chamber  1234  transitions the flow controller  1242  from an open or unsealed configuration or state (e.g., one in which a flow of gas or air can be drawn therethrough) to a sealed configuration or state (e.g., one in which a flow of gas and liquid cannot be drawn therethrough). 
     In some instances, a force can be exerted on the end portion  1263  of the actuator rod  1262  to place the actuator rod  1262  and/or actuator  1250  in its second position and/or configuration, as shown in  FIG.  34   . As described above, in some instances, prior to exerting the force on the end portion  1263  of the actuator rod  1262 , the actuator  1250  may be transitioned from a locked configuration or state to an unlocked configuration or state. When the actuator rod  1262  and/or the actuator  1250  is placed in its second position and/or configuration (e.g., when the control device  1200  is transitioned to a second state or operating mode), the inlet  1252  and the outlet  1253  of the actuator  1250  are each in fluid communication with the second fluid flow path  1254  while the first fluid flow path  1233  is sequestered, isolated, and/or otherwise not in fluid communication with the inlet  1252  and the outlet  1253 . As described in detail above, in some instances, contaminants such as, for example, dermally residing microbes or the like dislodged during the venipuncture event or throughout the bodily fluid collection process, can be entrained and/or included in the initial volume of the bodily fluid and thus, are sequestered in the sequestration chamber  1234  when the initial volume is sequestered therein. As such, the negative pressure otherwise exerted on or through the sequestration chamber  1234  is now exerted on or through the second fluid flow path  1254 . In response, bodily fluid can flow from the inlet  1252 , through the second fluid flow path  1254 , through the outlet  1253 , and into the fluid collection device coupled to the outlet  1253 . Accordingly, the device  1200  can function in a manner substantially similar to that of the device  800  and thus, the function of the device  1200  is not described in further detail herein. 
       FIGS.  35 - 40    illustrate a fluid control device  1300  according to an embodiment. The fluid control device  1300  can be similar in at least form and/or function to the fluid control devices described herein. More specifically, portions of the fluid control device  1300  can be similar to and/or substantially the same as corresponding portions of the fluid control devices  200 ,  300 ,  800 ,  900 ,  1000 ,  1100 , and/or  1200  described above. Accordingly, such portions of the fluid control device  1300  are not described in further detail herein. 
     The fluid control device  1300  (also referred to herein as “control device” or “device”) includes a housing  1330  and an actuator  1350 . As described above with reference to the control devices  800 , the control device  1300  can be arranged in a modular configuration such that the housing  1330  and the actuator  1350  can be physically and fluidically coupled to form the control device  1300 . In other embodiments, the control device  1300  need not be modular. That is to say, in some embodiments, the control device  1300  can be assembled during manufacturing and delivered to a supplier and/or end user as an assembled device. In other embodiments, the device  1300  can be monolithically formed and/or collectively formed with, for example, a fluid collection device, as described above. 
     The housing  1330  of the control device  1300  can be any suitable shape, size, and/or configuration. As shown in  FIGS.  35 - 37   , the housing  1330  forms and/or defines a sequestration chamber  1334  that is in selective fluid communication with a first port  1345  and a second port  1346 . The second port  1346  is configured to receive, include, and/or define a flow controller  1342  (see e.g.,  FIG.  36   ) and a restricted flow path  1332  (see e.g.,  FIG.  37   ). The first port  1345  and the second port  1346  are configured to be at least fluidically coupled to a portion of the actuator  1350  to allow for selective fluid flow between the housing  1330  and the actuator  1350 . As described in further detail herein, the sequestration chamber  1334  is configured (1) to receive a selective flow and/or volume of bodily fluid from a portion of the actuator  1350  via the first port  1345 , and (2) to sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid (e.g., at least a portion of an initial or first flow and/or volume of bodily fluid) within the sequestration chamber  1334 . The sequestration chamber  1334  can have any suitable shape, size, and/or configuration. For example, in some embodiments, the sequestration chamber  1334  can be, for example, a channel or the like formed in a portion of the housing  1330  and the housing  1330  can include and/or can be coupled to a cover  1338  configured to enclose the channel, thereby forming the sequestration chamber  1334 . In some embodiments, the housing  1330  can be substantially similar in at least form and/or function to the housing  1230  described in detail above with reference to  FIGS.  29 - 34   . Accordingly, the housing  1330  is not described in further detail herein. 
     The actuator  1350  of the control device  1300  can be any suitable shape, size, and/or configuration. For example, in some embodiments, the actuator  1350  can be substantially similar in at least form and/or function to the actuators  850  and/or  1250  described in detail above. Accordingly, such similar portions of the actuator  1350  are identified below but may not be described in further detail herein. 
     As shown in  FIGS.  38 - 40   , the actuator  1350  includes a body  1351  and an actuator rod  1362 . The body  1351  of the actuator  1350  includes an inlet  1352  and an outlet  1353 . The inlet  1352  and the outlet  1353  can be substantially similar in at least form and/or function to the inlet  852  and the outlet  853 , respectively, described above with reference to  FIGS.  19 - 25   . Thus, the inlet  1352  is configured to be placed in fluid communication with a bodily fluid source to receive a flow of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle, IV catheter, surgical tubing, other standard bodily-fluid transfer device, PICC line, or the like). The outlet  1353  is configured to be fluidically coupled to a fluid collection device (not shown in  FIGS.  35 - 40   ) such as, for example, a sample reservoir, a syringe, and/or other intermediary bodily fluid transfer device, adapter, or vessel such as, for example, a transfer device similar to those described in the &#39;510 publication. 
     The body  1351  of the actuator  1350  includes and/or defines a first port  1358  and a second port  1359 . The first port  1358  is in fluid communication with the inlet  1352  and the second port  1359  is in fluid communication with the outlet  1353 . In addition, the first port  1358  and the second port  1359  are configured to be at least fluidically coupled to the first port  1345  and the second port  1346 , respectively, of the housing  1330 . In some embodiments, the arrangement of the ports  1358  and  1359  of the actuator  1350  and the ports  1345  and  1346  of the housing  1330  can allow for and/or otherwise can provide a means of physically coupling the housing  1330  to the actuator  1350  as well as fluidically coupling the housing  1330  to the actuator  1350 . That is to say, in some embodiments, the arrangement of the ports  1358  and  1359  of the actuator  1350  and the ports  1345  and  1346  of the housing  1330  can allow for a modular configuration or arrangement as described above with reference to the control device  800 . In other embodiments, the housing  1330  and/or actuator  1350  need not be modular. 
     As shown in  FIGS.  39  and  40   , a portion of the actuator rod  1362  includes and/or is coupled to a set of seals  1365 . The seals  1365  can be, for example, o-rings, elastomeric material, silicone or any other suitable material or configuration as described above with reference to the seals  1265 . The arrangement of the actuator  1362  and the body  1351  of the actuator  1350  can be such that the seals  1365  form one or more fluid tight seals between the actuator rod  1362  and the inner surface of the body  1351 , as described above with reference to the actuator  850 . In the embodiment shown in  FIGS.  33  and  34   , the actuator rod  1362  includes and/or is coupled to three seals  1365  which form and/or define a first fluid flow path  1333  within the body  1351  of the actuator  1350  and a second fluid flow path  1354  within the body  1351  of the actuator  1350 . 
     As described above with reference to the device  800 , the device  1300  can be used to procure a bodily fluid sample having reduced contamination from microbes such as, for example, dermally residing microbes, microbes external to the bodily fluid source, and/or the like. For example, the actuator rod  1362  is configured to be moved or transitioned relative to the body  1351  between a first position or configuration and a second position or configuration. As shown in  FIG.  39   , when in the first position and/or configuration, the inlet  1352  of the actuator  1350  is in fluid communication with the first fluid flow path  1333 , which in turn, is in fluid communication with the first port  1358 . The outlet  1353  of the actuator  1350  is in fluid communication with the second fluid flow path  1354 , which in turn, is in fluid communication with the second port  1359 . Thus, when in the actuator  1350  and/or actuator rod  1362  is in the first position and/or configuration (e.g., when the control device  1300  is in a first state or operating mode), the negative pressure within the fluid collection device (not shown in  FIGS.  35 - 40   ) can result in a negative pressure (or negative pressure differential) within at least a portion of the sequestration chamber  1334  that is operable in drawing at least a portion of an initial flow, amount, or volume of bodily fluid from the inlet  1352 , through the first fluid flow path  1333 , and into the sequestration chamber  1334 . Moreover, in some instances, the initial volume and/or flow of bodily fluid can be transferred into the sequestration chamber  1334  until, for example, the bodily fluid disposed within the sequestration chamber  1334  transitions the flow controller  1342  from an open or unsealed configuration or state (e.g., one in which a flow of gas or air can be drawn therethrough) to a sealed configuration or state (e.g., one in which a flow of gas and liquid cannot be drawn therethrough). 
     In some instances, a force can be exerted on a first end portion  1363  of the actuator rod  1362  to place the actuator rod  1362  and/or actuator  1350  in its second position, state, operating mode, and/or configuration, as shown in  FIG.  35   . As described above, in some instances, prior to exerting the force on the first end portion  1363  of the actuator rod  1362 , the actuator  1350  may be transitioned from a locked configuration or state to an unlocked configuration or state. In some embodiments, the transition of the actuator rod  1362  can be achieved by and/or can otherwise result from user interaction and manipulation of the actuator rod  1362 , automatically in response to negative pressure and associated flow dynamics within the device  1300 , and/or enacted by or in response to an external energy source which creates dynamics that result in the transitioning of the actuator rod  1362 . 
     When the actuator rod  1362  and/or the actuator  1350  is placed in its second position and/or configuration (e.g., when the control device  1300  is transitioned to a second state or operating mode), the inlet  1352  and the outlet  1353  of the actuator  1350  are each in fluid communication with the second fluid flow path  1354  while the first fluid flow path  1333  is sequestered, isolated, and/or otherwise not in fluid communication with the inlet  1352  and the outlet  1353 . As described in detail above, in some instances, contaminants such as, for example, dermally residing microbes or the like dislodged during the venipuncture event or throughout the bodily-fluid collection process, can be entrained and/or included in the initial volume of the bodily fluid and thus, are sequestered in the sequestration chamber  1334  when the initial volume is sequestered therein. As such, the negative pressure otherwise exerted on or through the sequestration chamber  1334  is now exerted on or through the second fluid flow path  1354 . In response, bodily fluid can flow from the inlet  1352 , through the second fluid flow path  1354 , through the outlet  1353 , and into the fluid collection device coupled to the outlet  1353 . Accordingly, the device  1300  can function in a manner substantially similar to that of the device  800  and thus, the function of the device  1300  is not described in further detail herein. 
     In some instances, it may be desirable to isolate the negative pressure source (e.g., the fluid collection device from the inlet  1353  such as, for example, if it is desirable to collect multiple samples of bodily fluid using multiple fluid collection devices (e.g., syringes or the like). For example, in some instances, after filling the fluid collection device the user can engage the actuator  1350  and exert a force on a second end portion  1364  of the actuator rod  1362  to move and/or transition the actuator rod  1362  from its second position and/or configuration toward its first position and/or configuration. As such, the second fluid flow path  1354  no longer places the inlet  1352  in fluid communication with the outlet  1353 . Moreover, the flow controller  1342  can remain in the sealed state or configuration (e.g., fully saturated, wetted, and/or otherwise preventing flow therethrough) such that the outlet  1353  is substantially sequestered or isolated from the rest of the control device  1300 . In some instances, the user can then remove the filled fluid collection device and can couple a new fluid collection device to the outlet  1353 . With the new fluid collection device coupled to the outlet  1353 , the user can, for example, exert a force on the first end portion  1363  of the actuator rod  1362  to move and/or transition the actuator rod  1362  back to its second position, state, and/or configuration, as described above with reference to the actuator  850 . 
       FIGS.  41 - 44    illustrate a fluid control device  1400  according to an embodiment. The fluid control device  1400  can be similar in at least form and/or function to the fluid control devices described herein. More specifically, portions of the fluid control device  1400  can be similar to and/or substantially the same as corresponding portions of the fluid control devices  200 ,  300 ,  800 ,  900 ,  1000 ,  1100 ,  1200 , and/or  1300  described above. Accordingly, such portions of the fluid control device  1400  are not described in further detail herein. 
     The fluid control device  1400  (also referred to herein as “control device” or “device”) includes a housing  1430  and an actuator  1450 . As described above with reference to the control device  800 , the control device  1400  can be arranged in a modular configuration such that the housing  1430  and the actuator  1450  can be physically and fluidically coupled to form the control device  1400 . In other embodiments, the control device  1400  need not be modular. That is to say, in some embodiments, the control device  1400  can be assembled during manufacturing and delivered to a supplier and/or end user as an assembled device. In other embodiments, the device  1400  can be monolithically formed and/or collectively formed with, for example, a fluid collection device, as described above. 
     The housing  1430  of the control device  1400  can be any suitable shape, size, and/or configuration. The housing  1430  is configured to be in selective fluid communication with a portion of the actuator  1450  via a first port  1458  and a second port  1459 . As shown in  FIGS.  43  and  44   , the housing  1430  includes a bladder  1478  that can be transitioned from a first configuration and/or state to a second configuration and/or state to form and/or define a sequestration chamber  1434 . As described in further detail herein, the bladder  1478  is configured to transition from the first configuration and/or state ( FIG.  43   ) to the second configuration and/or state ( FIG.  44   ) to form and/or define the sequestration chamber  1434 , which in turn, is configured to receive a selective flow and/or volume of bodily fluid from a portion of the actuator  1450  via the first port  1458 . After the bladder  1478  is placed in the second configuration and/or state, the sequestration chamber  1434  can sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid (e.g., at least a portion of an initial or first flow and/or volume of bodily fluid) within the sequestration chamber  1434 . 
     While the bladder  1478  is particularly shown in  FIGS.  43  and  44   , in other embodiments, the bladder  1478  can be any suitable shape, size, and/or configuration. Similarly, the bladder  1478  can be formed of any suitable material (e.g., any suitable biocompatible material such as those described herein and/or any other suitable material). In some embodiments, the bladder  1478  can be arranged and/or configured as, for example, a bellows, an expandable bag, a flexible pouch, and/or any other suitable reconfigurable container or the like. In addition, the sequestration chamber  1434  formed by the bladder  1478  can have any suitable shape, size, and/or configuration. In some embodiments, the housing  1430  can be substantially similar in at least form and/or function to the housing  1230  and/or  1330  described in detail above with reference to  FIGS.  29 - 34    and  FIGS.  35 - 40   , respectively. Accordingly, the housing  1430  is not described in further detail herein. 
     The actuator  1450  of the control device  1400  can be any suitable shape, size, and/or configuration. For example, in some embodiments, the actuator  1450  can be substantially similar in at least form and/or function to the actuators  850 ,  1250 , and/or  1350  described in detail above. Accordingly, such similar portions of the actuator  1450  are identified below but may not be described in further detail herein. 
     As shown in  FIGS.  41 - 44   , the actuator  1450  includes a body  1451  and an actuator rod  1462 . The body  1451  of the actuator  1450  includes an inlet  1452  and an outlet  1453 . The inlet  1452  and the outlet  1453  can be substantially similar in at least form and/or function to the inlet  1252  and the outlet  1253 , respectively, described above with reference to  FIGS.  29 - 34   . Thus, the inlet  1452  is configured to be placed in fluid communication with a bodily fluid source to receive a flow of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle, IV catheter, surgical tubing, other standard bodily-fluid transfer device, PICC line, or the like). The outlet  1453  is configured to be fluidically coupled to a fluid collection device (not shown in  FIGS.  41 - 44   ) such as, for example, a sample reservoir, a syringe, and/or other intermediary bodily fluid transfer device, adapter, or vessel such as, for example, a transfer device similar to those described in the &#39;510 publication. 
     The body  1451  of the actuator  1450  includes and/or defines the first port  1458  and the second port  1459 . Although not shown, the first port  1458  is configured to be in fluid communication with the inlet  1452  and the second port  1459  is configured to be in fluid communication with the outlet  1453 . In addition, the first port  1458  is configured to be in fluid communication with the housing  1430  and more particularly, an inner volume or an inlet side of the bladder  1478  that forms the sequestration chamber  1434 . The second port  1459  is configured to be in fluid communication with a portion of the housing  1430  defined between an inner surface of the housing  1430  and an outer surface of the bladder  1478 . In other words, the second port  1459  is in fluid communication with a portion of the housing  1430  that is isolated and/or sequestered from the inner volume of the bladder  1478  that forms the sequestration chamber  1434 . In some embodiments, the arrangement of the ports  1458  and  1459  of the actuator  1450  can allow for and/or otherwise can provide a means of physically coupling the housing  1430  to the actuator  1450  as well as fluidically coupling the housing  1430  to the actuator  1450 . That is to say, in some embodiments, the arrangement of the ports  1458  and  1459  of the actuator  1450  can allow for a modular configuration or arrangement as described above with reference to the control device  800 . In other embodiments, the housing  1430  and/or actuator  1450  need not be modular. 
     Although not shown in  FIGS.  41 - 44   , a portion of the actuator rod  1462  includes and/or is coupled to a set of seals. The seals can be, for example, o-rings, elastomeric material, silicone or any other suitable material or configuration as described above with reference to the seals  1265  and/or  1365 . The arrangement of the actuator rod  1462  and the body  1451  of the actuator  1450  can be such that the seals form one or more fluid tight seals between the actuator rod  1462  and the inner surface of the body  1451 , as described above with reference to the actuators  850 ,  1250 , and/or  1350 . Moreover, as described above with reference to the actuators  1250  and/or  1350 , the actuator rod  1462  can include and/or can be coupled to a set seals which selectively form and/or define a first fluid flow path configured to place the inlet  1452  of the actuator  1450  in fluid communication with the first port  1458  (e.g., when in a first position, state, operating mode, and/or configuration) and a second fluid flow path configured to place the inlet  1452  in fluid communication with the outlet  1453  (e.g., when in a second position, state, operating mode, and/or configuration). 
     As described above with reference to the devices  800 ,  1200 , and/or  1300 , the device  1400  can be used to procure a bodily fluid sample having reduced contamination from microbes such as, for example, dermally residing microbes, microbes external to the bodily fluid source, and/or the like. For example, as described above with reference to the devices  1200  and/or  1300 , the actuator rod  1462  can be configured to be moved or transitioned relative to the body  1451  between a first position or configuration and a second position or configuration. When in the first position and/or configuration, the inlet  1452  of the actuator  1450  is in fluid communication with, for example, the first fluid flow path, which in turn, is in fluid communication with the first port  1458  (not shown in  FIGS.  41 - 44   ). The outlet  1453  of the actuator  1450  is in fluid communication with the second fluid flow path  1454 , which in turn, is in fluid communication with the second port  1459 . Thus, when in the actuator  1450  and/or actuator rod  1462  is in the first position and/or configuration (e.g., when the control device  1400  is in a first state or operating mode), the negative pressure within the fluid collection device (not shown in  FIGS.  41 - 44   ) can result in a negative pressure (or negative pressure differential) within the portion of the housing  1430  defined between the inner surface of the housing  1430  and the outer surface of the bladder  1478 . 
     As shown in  FIG.  43   , the bladder  1478  can be in a first state and/or configuration prior to the fluid collection device being coupled to the outlet  1453 . In some embodiments, for example, the bladder  1478  can have a flipped, inverted, collapsed, and/or empty configuration prior to coupling the fluid collection device to the outlet  1453 . As shown in  FIG.  44   , the bladder  1478  can be configured to transition from the first state and/or configuration to a second state and/or configuration in response to the negative pressure differential resulting from the coupling of the fluid collection device to the outlet  1453 . In other words, the negative pressure differential can be operable to transition the bladder  1478  from a collapsed or unexpanded configuration and/or state to an expanded configuration and/or state. For example, in some embodiments, the transitioning of the bladder  1478  can be similar to the transitioning and/or “flipping” of the diaphragm  576 , described above with reference to  FIGS.  11  and  12   . 
     As described above, the bladder  1478  can be configured to transition from the first configuration and/or state to the second configuration and/or state to form and/or define the sequestration chamber  1434 . In some embodiments, the transitioning of the bladder  1478  results in an increase in an inner volume of the bladder  1478  (i.e., the sequestration chamber  1434 ). The increase in the inner volume can, in turn, result in a negative pressure differential between the sequestration chamber  1434  defined by the bladder  1478  and the inlet  1452  that is operable in drawing at least a portion of an initial flow, amount, or volume of bodily fluid from the inlet  1452 , through the first port  1458 , and into the sequestration chamber  1434 . Moreover, in some instances, the initial volume and/or flow of bodily fluid can be transferred into the sequestration chamber  1434  until, for example, the bladder  1478  is fully expanded, and/or until the negative pressure differential is reduced and/or equalized. 
     Having transferred the initial volume of bodily fluid into the sequestration chamber  1434 , a force can be exerted on a first end portion  1463  of the actuator rod  1462  to place the actuator rod  1462  and/or actuator  1450  in its second position, state, operating mode, and/or configuration, as described in detail above with reference to the devices  1200  and/or  1300 . As described above, in some instances, prior to exerting the force on the first end portion  1463  of the actuator rod  1462 , the actuator  1450  may be transitioned from a locked configuration or state to an unlocked configuration or state. In some embodiments, the transition of the actuator rod  1462  can be achieved by and/or can otherwise result from user interaction and manipulation of the actuator rod  1462 , automatically in response to negative pressure and associated flow dynamics within the device  1400 , and/or enacted by or in response to an external energy source which creates dynamics that result in the transitioning of the actuator rod  1462 . 
     When the actuator rod  1462  and/or the actuator  1450  is placed in its second position and/or configuration (e.g., when the control device  1400  is transitioned to a second state or operating mode), the inlet  1452  and the outlet  1453  of the actuator  1450  are placed in fluid communication (e.g., via the second fluid flow path (not shown)) while the first fluid flow path (not shown) and/or the first port  1458  is sequestered, isolated, and/or otherwise not in fluid communication with the inlet  1452  and/or the outlet  1453 . As described in detail above, in some instances, contaminants such as, for example, dermally residing microbes or the like dislodged during the venipuncture event or throughout the bodily-fluid collection process, can be entrained and/or included in the initial volume of the bodily fluid and thus, are sequestered in the sequestration chamber  1434  when the initial volume is sequestered therein. As such, the negative pressure otherwise exerted on or through the housing  1430  is now exerted on or through the outlet  1453  and the inlet  1452  via, for example, the second fluid flow path (not shown). In response, bodily fluid can flow from the inlet  1452 , through the body  1451  of the actuator  1450 , through the outlet  1453 , and into the fluid collection device coupled to the outlet  1453 . Accordingly, the device  1400  can function in a manner substantially similar to that of the devices  800 ,  1200 , and/or  1300  and thus, the function of the device  1400  is not described in further detail herein. 
     While the device  1400  is described above as including the housing  1430  and the actuator  1450 , in other embodiments, a fluid control device can have, for example, at least a partially integrated design. For example,  FIGS.  45 - 50    illustrate a fluid control device  1500  according to an embodiment. The fluid control device  1500  can be similar in at least form and/or function to the fluid control devices described herein. More specifically, portions of the fluid control device  1500  can be similar to and/or substantially the same as corresponding portions of at least the fluid control device  1400  described above with reference to  FIGS.  41 - 44   . Accordingly, such portions of the fluid control device  1500  are not described in further detail herein. 
     The fluid control device  1500  (also referred to herein as “control device” or “device”) includes an actuator  1550  having an actuator body  1551  and an actuator rod  1562 . The actuator  1550  can be any suitable shape, size, and/or configuration. For example, in some embodiments, the actuator  1550  can be substantially similar in at least form and/or function to the actuators  850 ,  1250 ,  1350 , and/or  1450  described in detail above. Accordingly, such similar portions of the actuator  1550  are identified below but may not be described in further detail herein. 
     As shown in  FIGS.  45 - 50   , the actuator  1550  includes an inlet  1552  and an outlet  1553 , each of which is in fluid communication with the body  1551 . The inlet  1552  and the outlet  1553  can be substantially similar in at least form and/or function to the inlet  1252  and the outlet  1253 , respectively, described above with reference to  FIGS.  29 - 34   . Thus, the inlet  1552  is configured to be placed in fluid communication with a bodily fluid source to receive a flow of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle, IV catheter, surgical tubing, other standard bodily-fluid transfer device, PICC line, or the like). The outlet  1553  is configured to be fluidically coupled to a fluid collection device (not shown in  FIGS.  45 - 50   ) such as, for example, a sample reservoir, a syringe, and/or other intermediary bodily fluid transfer device, adapter, or vessel such as, for example, a transfer device similar to those described in the &#39;510 publication. 
     As shown in  FIGS.  48 - 50   , the actuator  1550  includes a bladder  1578  that can be transitioned from a first configuration and/or state ( FIG.  48   ) to a second configuration and/or state ( FIG.  49   ) to form and/or define a sequestration chamber  1534 . As described in further detail herein, the bladder  1578  is configured to transition from the first configuration and/or state ( FIG.  48   ) to the second configuration and/or state ( FIGS.  49  and  50   ) to form and/or define the sequestration chamber  1534 , which in turn, is configured to receive a selective flow and/or volume of bodily fluid from the inlet  1552 . After the bladder  1578  is placed in the second configuration and/or state, the sequestration chamber  1534  can sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid (e.g., at least a portion of an initial or first flow and/or volume of bodily fluid) within the sequestration chamber  1534 . As such, the bladder  1578  can be substantially similar in at least form and/or function to the bladder  1478  described above with reference to  FIGS.  41 - 44    and thus, is not described in further detail herein. 
     As shown in  FIGS.  46  and  48 - 50   , the body  1551  of the actuator  1550  includes and/or defines a port  1559  configured to be in fluid communication with the outlet  1553 . In addition, the port  1559  defines a fluid flow path that is configured to be in fluid communication with a portion of the actuator  1550  defined between an inner surface of the body  1551  and an outer surface of the bladder  1578 . In other words, the port  1559  is in fluid communication with a portion of the actuator  1550  that is isolated and/or sequestered from the inner volume of the bladder  1578  that forms and/or that is configured to form the sequestration chamber  1534 . 
     As described above with reference to the devices  1200 ,  1300 , and/or  1400 , a portion of the actuator rod  1562  includes and/or is coupled to a set of seals  1565 . The seals  1565  can be, for example, o-rings, elastomeric material, silicone or any other suitable material or configuration as described above with reference to the seals  1265  and/or  1365 . The arrangement of the actuator rod  1562  and the body  1551  of the actuator  1550  can be such that the seals  1565  form one or more fluid tight seals between the actuator rod  1562  and the inner surface of the body  1551 , as described above with reference to the actuators  850 ,  1250 , and/or  1350 . Moreover, as described above with reference to the actuators  1250  and/or  1350 , the set seals  1565  can be arranged along the actuator rod  1562  to selectively form and/or define a fluid flow path  1554  that is sequestered from and/or fluidically isolated from the inlet  1552  when the actuator rod  1562  is in a first position and/or configuration and that is configured to place the inlet  1552  in fluid communication with the outlet  1553  when the actuator rod  1562  is in a second position and/or configuration. 
     As described above with reference to the devices  800 ,  1200 ,  1300 , and/or  1400 , the device  1500  can be used to procure a bodily fluid sample having reduced contamination from microbes such as, for example, dermally residing microbes, microbes external to the bodily fluid source, and/or the like. For example, as described above with reference to the devices  1200 ,  1300 , and/or  1400 , the actuator rod  1562  can be configured to be moved or transitioned relative to the body  1551  between the first position or configuration and the second position or configuration. When in the first position and/or configuration, the inlet  1552  of the actuator  1550  is in fluid communication with a fluid flow path, which in turn, is in fluid communication with a portion of the body  1551  that is disposed on an inlet side of the bladder  1578 . In other words, the fluid flow path establishes fluid communication between the inlet  1553  and the bladder  1578  and/or the sequestration chamber  1534  at least partially defined by the bladder  1578  when the bladder  1578  is transitioned to the second configuration and/or state. The outlet  1553  of the actuator  1550  is in fluid communication with the port  1559 . Thus, when in the actuator  1550  and/or actuator rod  1562  is in the first position and/or configuration (e.g., when the control device  1500  is in a first state or operating mode), the negative pressure within the fluid collection device (not shown in  FIGS.  45 - 50   ) can result in a negative pressure (or negative pressure differential) within the portion of the actuator body  1551  defined between the inner surface of the body  1551  and the outer surface of the bladder  1578 , as described above with reference to the device  1400 . 
     As shown in  FIG.  48   , the bladder  1578  can be in a first state and/or configuration prior to the fluid collection device being coupled to the outlet  1553 . In some embodiments, for example, the bladder  1578  can have a flipped, inverted, collapsed, and/or empty configuration prior to coupling the fluid collection device to the outlet  1553 . Moreover, when the actuator rod  1562  is in the first position and/or configuration, the fluid flow path  1554  is fluidically isolated from the inlet  1552 . Accordingly, as shown in  FIG.  49   , the bladder  1578  can be configured to transition from the first state and/or configuration to a second state and/or configuration in response to the negative pressure differential resulting from the coupling of the fluid collection device to the outlet  1553 . In other words, the negative pressure differential can be operable to transition the bladder  1578  from a collapsed or unexpanded configuration and/or state to an expanded configuration and/or state. For example, in some embodiments, the transitioning of the bladder  1578  can be similar to the transitioning and/or “flipping” of the diaphragm  576 , described above with reference to  FIGS.  11  and  12   . In other embodiments, the bladder  1578  can be configured to transition between a first state and/or configuration to a second state and/or configuration in any suitable manner such as any of those described herein. 
     As described above, the bladder  1578  can be configured to transition from the first configuration and/or state to the second configuration and/or state to form and/or define the sequestration chamber  1534 . In some embodiments, the transitioning of the bladder  1578  results in an increase in an inner volume of the bladder  1578  (i.e., the sequestration chamber  1534 ). The increase in the inner volume can, in turn, result in a negative pressure differential between the sequestration chamber  1534  defined by the bladder  1578  and the inlet  1552  that is operable in drawing at least a portion of an initial flow, amount, or volume of bodily fluid from the inlet  1552  and a portion of the actuator body  1551 , and into the sequestration chamber  1534 . Moreover, in some instances, the initial volume and/or flow of bodily fluid can be transferred into the sequestration chamber  1534  until, for example, the bladder  1578  is fully expanded, and/or until the negative pressure differential is reduced and/or equalized. 
     Having transferred the initial volume of bodily fluid into the sequestration chamber  1534 , a force can be exerted on a first end portion  1563  of the actuator rod  1562  to place the actuator rod  1562  and/or actuator  1550  in its second position, state, operating mode, and/or configuration, as described in detail above with reference to the devices  1200  and/or  1300 . As described above, in some instances, prior to exerting the force on the first end portion  1563  of the actuator rod  1562 , the actuator  1550  may be transitioned from a locked configuration or state to an unlocked configuration or state. In some embodiments, the transition of the actuator rod  1562  can be achieved by and/or can otherwise result from user interaction and manipulation of the actuator rod  1562 , automatically in response to negative pressure and associated flow dynamics within the device  1500 , and/or enacted by or in response to an external energy source which creates dynamics that result in the transitioning of the actuator rod  1562 . 
     When the actuator rod  1562  and/or the actuator  1550  is placed in its second position and/or configuration (e.g., when the control device  1500  is transitioned to a second state or operating mode), the inlet  1552  and the outlet  1553  of the actuator  1550  are placed in fluid communication via the fluid flow path  1554  while the sequestration chamber  1534  is sequestered, isolated, and/or otherwise not in fluid communication with the inlet  1552  and/or the outlet  1553 . As described in detail above, in some instances, contaminants such as, for example, dermally residing microbes or the like dislodged during the venipuncture event or throughout the bodily-fluid collection process, can be entrained and/or included in the initial volume of the bodily fluid and thus, are sequestered in the sequestration chamber  1534  when the initial volume is sequestered therein. 
     As described above with reference to the devices  1200  and/or  1300 , transitioning the actuator rod  1562  to the second position and/or configuration is such that the fluid flow path  1554  places the inlet  1552  in fluid communication with the outlet  1553 . For example, transitioning the actuator rod  1562  to the second position and/or configuration can move the seals  1565  relative to the inlet  1552  such that the fluid flow path  1554  is placed in fluid communication with both the inlet  1552  and the outlet  1553 . As such, the negative pressure otherwise exerted on the outer surface of the bladder  1578  is now exerted on or through the outlet  1553  and the inlet  1552  via the fluid flow path  1554 . In response, bodily fluid can flow from the inlet  1552 , through the fluid flow path  1554 , through the outlet  1553 , and into the fluid collection device coupled to the outlet  1553 . Accordingly, the device  1500  can function in a manner substantially similar to that of the devices  800 ,  1200 ,  1300 , and/or  1400  and thus, the function of the device  1500  is not described in further detail herein. 
     While the actuators  850 ,  1250 ,  1350 ,  1450 , and  1550  have been described in detail above as being transitioned in response to an external force such as, for example, a force exerted by a user, in other embodiments, a fluid control device can include one or more actuators that can be transitioned in response to any suitable force, input, change of state or configuration, etc. For example,  FIGS.  51  and  52    illustrate a portion of a fluid control device  1600  according to an embodiment. The fluid control device  1600  can be similar in at least form and/or function to the fluid control devices described herein. More specifically, portions of the fluid control device  1600  can be similar to and/or substantially the same as corresponding portions of at least the fluid control devices  500 ,  600 , and/or  700  described above. Accordingly, such portions of the fluid control device  1600  are not described in further detail herein. 
     As shown in  FIGS.  51  and  52   , the fluid control device  1600  (also referred to herein as “control device” or “device”) includes a housing  1630  having an inlet  1631  and an outlet  1636 , and having and/or being coupled to an actuator  1650 . As described in further detail herein, the housing  1630  defines a set of fluid flow paths  1633  and  1654  configured to establish fluid communication between one or more portions of the housing  1630  to selectively receive a flow of fluid therethrough (e.g., a liquid and/or a gas). The inlet  1631  is configured to be placed in fluid communication with a bodily fluid source to receive a flow of bodily fluid therefrom (e.g., via a lumen-containing device such as a needle or the like, as described in detail above). The outlet  1636  is configured to be fluidically coupled to a fluid collection device (not shown in  FIGS.  51  and  52   ). The inlet  1631 , the outlet  1636 , and the fluid collection device can be substantially similar to those described above and thus, are not described in further detail herein. 
     The housing  1630  can be any suitable shape, size, and/or configuration. In some embodiments, the housing  1630  can have a size that is at least partially based on a volume of bodily fluid configured to be at least temporarily stored within one or more portions of the housing  1630 . As described above, the housing  1630  of the control device  1600  is configured to (1) receive a flow and/or volume of bodily fluid via the inlet  1631  and (2) sequester (e.g., separate, segregate, contain, retain, isolate, etc.) the flow and/or volume of bodily fluid within a sequestration chamber  1634  included in and/or at least partially formed by the housing  1630 . In some embodiments, aspects of the housing  1630  can be substantially similar, for example, to aspects of the housings  630 ,  730 , and/or  830 . Accordingly, some portions and/or aspects of the housing  1630  are not described in further detail herein. 
     The housing  1630  includes and/or is coupled to the actuator  1650  configured to selectively control a flow of bodily fluid through the housing  1630 . In this embodiment, the actuator  1650  includes a diaphragm  1676  and an actuator rod  1662  having a set of seals (e.g., seals  1665  and  1666 ). As described in further detail herein, the diaphragm  1676  and the actuator rod  1662  are configured to transition, move, and/or otherwise reconfigure within the housing  1630  in response to a negative pressure differential within at least a portion of the device. More specifically, the actuator  1650  is configured to move between a first state in which the inlet  1631  is placed in fluid communication with the sequestration chamber  1634  and a second state in which the inlet  1631  is placed in fluid communication with the outlet  1636  via the fluid flow path  1654 , as described in detail above with reference to the control device  500 . 
     In some embodiments, the diaphragm  1676  can be similar to, for example, the diaphragms  576 ,  676 , and/or  776  described in detail above. Accordingly, the diaphragm  1676  can be at least partially disposed in a sequestration portion of the housing  1630  to define and/or to form at least a portion of the sequestration chamber  1634 . As described in detail above, the diaphragm  1676  can be configured to transition, move, flip, and/or otherwise reconfigure from a first state to a second state in response to a negative pressure differential, which can be operable to draw an initial volume of bodily fluid into the sequestration chamber  1634  and/or to sequester the initial volume of bodily fluid in the sequestration chamber  1634  once disposed therein. Moreover, as shown in  FIGS.  51  and  52   , the diaphragm  1676  can include and/or can be coupled to a flow controller  1642 . The flow controller  1642  can be any suitable flow controller such as any of those described herein. For example, in some embodiments, the flow controller  1642  can be a semi-permeable member or membrane such as an air permeable/liquid impermeable barrier (e.g., a blood barrier). 
     As described in detail above, the flow controller  1642  can be configured to transition from a first state in which the flow controller  1642  allows a flow of gas (e.g., air) to pass through the flow controller  1642  while preventing a flow of liquid (e.g., bodily fluid) to pass therethrough, to a second state in which the flow controller  1642  limits and/or substantially prevents a flow of gas and liquid to pass through the flow controller  1642 . In some embodiments, the flow controller  1642  can be configured to transition from the first state to the second state in response to contact with, for example, the initial volume of bodily fluid (e.g., at least a portion of the initial volume of bodily fluid can wet or saturate the flow controller  1642  to place the flow controller  1642  in the second state). 
     While the diaphragms  576 ,  676 , and  776  are shown and described above as including a pin, rod, post, and/or the like that include and/or are coupled to one or more seals (e.g., the seals  565 ,  665 , and  765 , respectively), in the embodiment shown in  FIGS.  51  and  52   , the diaphragm  1676  includes a pin  1677  (e.g., a rod, an extension, a protrusion, a latch, a lock, and/or any other suitable feature, member, and/or mechanism) that does not include and/or is not coupled to a seal. For example, in this embodiment, the pin  1677  extends through a portion of the housing  1630  to selectively engage a portion of the actuator rod  1662 , which in turn includes one or more seals (e.g., the seals  1665  and  1666 ), as described in further detail herein. 
     As shown in  FIGS.  51  and  52   , the actuator rod  1662  is movably disposed in, for example, an actuator portion  1639  of the housing  1630 . The actuator rod  1662  includes a first seal  1665  and a second seal  1666  and is in contact with an energy storage member  1667  such as a spring or the like disposed within the actuator portion  1639  of the housing  1630 . In the embodiment shown in  FIGS.  51  and  52   , the arrangement of the actuator  1650  can be such that a first end portion of the actuator rod  1662  is in selective contact with the pin  1677  of the diaphragm  1676  and a second end portion of the actuator rod  1662  (opposite the first end portion) is in contact with and/or otherwise is engaged with the energy storage member  1667 . 
     As shown in  FIG.  51   , when the actuator  1650  is in a first state, the pin  1677  of the diaphragm  1676  can engage the actuator rod  1662  to maintain the actuator rod  1662  in a first or initial state and/or position in which the energy storage member  1667  has a relatively high potential energy (e.g., the energy storage member  1667  can be a spring maintained and/or held in a compressed state when in the first state). Furthermore, the first seal  1665  coupled to and/or disposed on the actuator  1662  is in a first or initial position in which the fluid flow path  1633  establishes fluid communication between the inlet  1631  and the sequestration chamber  1634  when the actuator  1650  is in the first state. As shown, the second seal  1666  coupled to and/or disposed on the actuator rod  1662  is likewise in a first or initial position in which the second seal  1666  is spaced apart from a seal surface  1640  formed by at least a portion of the actuator portion  1639  of the housing  1630 . 
     In some embodiments, the separation of the second seal  1666  from the seal surface  1640  can be such that the fluid flow path  1654  places the outlet  1636  in fluid communication with the sequestration chamber  1634  via a restricted flow path  1632  (see  FIG.  52   ). In some embodiments, the restricted flow path  1632  can be similar in at least form and/or function to any of the restricted flow paths described herein (e.g., the restricted flow paths  232 ,  832 ,  1232 , and/or  1332 ). As such, the restricted flow path  1632  can be configured to modulate a magnitude of a negative pressure differential applied on or in the sequestration chamber  1634  and/or a rate at which a negative pressure differential increases within the sequestration chamber  1634 . In other embodiments, the outlet  1636  can be in fluid communication with the sequestration chamber  1634  via any suitable flow path, port, opening, valve, etc. In other words, in some embodiments, the control device  1600  need not include the restricted flow path  1632 . 
     As shown in  FIG.  51   , when the actuator  1650  is in the first state, the actuator rod  1662  can be maintained in a first state or position in which the fluid flow path  1633  places the inlet  1631  in fluid communication with the sequestration chamber  1634 , and the fluid flow path  1654  places the outlet  1636  in fluid communication with the sequestration chamber  1634  via the restricted flow path  1632 . Accordingly, when a fluid collection device (such as those described herein) is coupled to the outlet  1636 , a negative pressure defined in and/or otherwise produced by the fluid collection device can be operable to draw the initial volume of bodily fluid into the sequestration chamber  1634 . 
     As described in detail above, the actuator  1650  can be transitioned to a second state and/or configuration in response to the initial volume being transferred into the sequestration chamber  1634 . For example, in some embodiments, the initial volume of bodily fluid can be drawn into the sequestration chamber  1634  in response to a negative pressure being exerted through the flow controller  1642  (e.g., the selectively permeable membrane). In some instances, at least a portion of the bodily fluid drawn into the sequestration chamber  1634  can come into contact with the flow controller  1642 , which in turn, can transition the flow controller  1642  from the first state to the second state (e.g., the flow controller  1642  limits and/or substantially prevents a flow of gas and liquid therethrough). As such, a negative pressure exerted on a surface of the diaphragm  1676  can build and can become sufficient to transition, move, and/or flip the diaphragm from a first state and/or configuration to a second state and/or configuration (see  FIG.  52   ). In some embodiments, the transitioning of the diaphragm  1676  can correspond with and/or can be in response to the flow controller  1642  being transitioned from the first state to the second state (e.g., becoming fully wetted or the like, as described in detail above). In other embodiments, the diaphragm  1676  can transition before or after the flow controller  1642  has transitioned from the first state to the second state. In still other embodiments, the control device  1600  need not include the flow controller  1642  and the diaphragm  1676  can be configured to transition in response to being exposed to the negative pressure differential produced by the fluid collection device. In some such embodiments, the diaphragm  1676  (and/or at least a portion thereof) can be configured to act in a similar manner to the flow controller  1642  by transitioning from the first state to the second state in a predictable and/or predetermined manner after being exposed to a predetermined negative pressure differential or a predetermined rate of change in negative pressure. Moreover, the transitioning of the diaphragm  1676  can be automatic (e.g., is not a result of user intervention). 
     As shown in  FIG.  52   , when the diaphragm  1676  is transitioned, moved, flipped, etc., the pin  1677  can be moved within the housing  1630  and relative to the actuator rod  1662 . More particularly, the transitioning of the diaphragm  1676  can move the pin  1677  a sufficient amount that the pin  1677  is disengaged from the actuator rod  1662 . As such, the energy storage member  1667  (e.g., spring) can be configured to release and/or convert at least a portion of its potential energy. As a specific example, in this embodiment, moving the pin  1677  can allow the spring  1667  to expand from a first or compressed state to a second or substantially uncompressed state. The transitioning of the energy storage member  1667  (e.g., spring) from the first state to the second state, in turn, moves the actuator rod  1662  within the actuator portion  1639  from a first state and/or position to a second state and/or position. 
     As shown in  FIG.  52   , when the actuator rod  1662  is in the second state and/or position, the first seal  1665  can be placed in a second or subsequent position in which the first seal  1665  sequesters the sequestration chamber  1634  from the inlet  1631 . Similarly, the second seal  1666  can be placed in a second or subsequent position in which the second seal  1666  is pushed (e.g., by the energy storage member  1667 ) against the seal surface  1640 , which in turn, sequesters the flow controller  1642  from the fluid flow path  1654 . Furthermore, the placement of the first seal  1665  and the second seal  1666  when the actuator rod  1662  is in the second state and/or position is such that the fluid flow path  1633  is placed in fluid communication with the fluid flow path  1654 . Thus, a negative pressure differential produced by the fluid collection device coupled to the outlet  1636  can be operable to draw a subsequent volume of bodily fluid from the inlet  1631 , through the fluid flow path  1633  and  1654 , through the outlet  1636 , and into the fluid collection device. Moreover, the collecting and sequestering of the initial volume of bodily fluid can result in the subsequent volume(s) of bodily fluid being substantially free from contaminants, as described in detail above. 
     Referring now to  FIG.  53   , a flowchart is presented illustrating a method  10  of using a fluid control device to obtain a bodily fluid sample with reduced contamination according to an embodiment. The fluid control device can be similar to and/or substantially the same as any of the fluid control devices described in detail above. The method  10  includes establishing fluid communication between a bodily fluid source and an inlet of the fluid collection device, at  11 . For example, in some embodiments, a user can manipulate the fluid control device to physically and/or fluidically couple the inlet to a lumen-containing device (e.g., a needle, IV, PICC line, etc.) in fluid communication with a patient. 
     A fluid collection device is coupled to an outlet of the fluid control device, at  12 . The coupling of the fluid collection device to the outlet is configured to produce a negative pressure differential within at least a portion of the fluid control device, as described in detail above. In some embodiments, for example, the fluid collection device can be a sample bottle or container that defines a negative pressure. In other embodiments, the fluid collection device can be a syringe or the like that can be manipulated to produce a negative pressure. Accordingly, a negative pressure differential can be produced within one or more portions of the fluid control device, as described above with reference to the control devices  100 ,  200 ,  300 ,  400 ,  500 ,  600 ,  700 ,  800 ,  900 ,  1000 ,  1100 ,  1200 ,  1300 ,  1400 ,  1500 , and/or  1600 . 
     An initial volume of bodily fluid is received from the inlet and into a sequestration portion of the fluid control device in response to the negative pressure differential, at  13 . For example, in some embodiments, the sequestration portion can be similar to and/or substantially the same as the sequestration chamber  1234  described above with reference to  FIGS.  29 - 34   . In other embodiments, the sequestration portion can be similar to and/or substantially the same as the sequestration chamber  1634 . In still other embodiments, the sequestration portion can be similar to and/or substantially the same as any of the sequestration chambers described herein. Furthermore, in some instances, the initial volume of bodily fluid can include contaminants entrained therein, which may otherwise result in false results during testing of a bodily fluid sample. 
     In response to contact with at least a portion of the initial volume of bodily fluid, a flow controller disposed in the sequestration portion is transitioned from a first state in which the flow controller allows a flow of a gas through the flow controller and prevents a flow of bodily fluid through the flow controller, to a second state in which the flow controller prevents a flow of gas and bodily fluid through the flow controller, at  14 . For example, in some embodiments, the flow controller can be a selectively permeable member or membrane (e.g., a fluid or blood barrier and/or the like), as described above with reference to the flow controller  242 . In other embodiments, the flow controller can be similar to and/or substantially the same as any of the flow controllers described herein. Thus, in some embodiments, the contact with at least the portion of the initial volume of bodily fluid can, for example, wet or saturate the flow controller such that the flow controller limits and/or substantially prevents a flow of gas and liquid (e.g., bodily fluid) therethrough. In other embodiments, the flow controller can be a bladder and/or diaphragm that is configured to be transitioned in response to a negative pressure differential. For example, in such embodiments, a flow controller can be a substantially impermeable bladder or diaphragm that can transition from a first state to a second state when a negative pressure differential applied to a surface of the bladder and/or diaphragm exceeds a threshold amount of negative pressure. 
     The initial volume of bodily fluid is sequestered in the sequestration portion after the flow controller is transitioned to the second state, at  15 . For example, in some embodiments, the fluid control device can include an actuator and/or any other suitable feature or mechanism configured to transition after the flow controller is placed in its second configuration to sequester the initial volume of bodily fluid. In some embodiments, the actuator can transition from a first state to a second state to automatically sequester the initial volume of bodily fluid in the sequestration portion, as described above with reference to, for example, the actuator  1650 . In other embodiments, the actuator can transition from a first state to a second state in response to a force exerted by a user, as described above with reference to, for example, the actuator  850 . In still other embodiments, the fluid control device can sequester the initial volume of bodily fluid in the sequestration portion in any suitable manner such as those described herein. 
     After sequestering the initial volume of bodily fluid, a subsequent volume of bodily fluid is transferred from the inlet, through the outlet, and into the fluid collection device, at  16 . As described in detail above, in some instances, sequestering the initial volume of bodily fluid in the sequestration portion of the fluid control device can likewise sequester contaminants contained in the initial volume. Accordingly, contaminants in the subsequent volume of bodily fluid can be reduced or substantially eliminated. 
     While various embodiments have been described above, it should be understood that they have been presented by way of example only, and not limitation. Where schematics and/or embodiments described above indicate certain components arranged in certain orientations or positions, the arrangement of components may be modified. While the embodiments have been particularly shown and described, it will be understood that various changes in form and details may be made. For example, while the control devices  100 ,  200 ,  300 ,  400 ,  500 ,  600 ,  700 ,  800 ,  900 ,  1000 ,  1100 ,  1200 ,  1300 ,  1400 , and/or  1500  are described as transferring a bodily fluid into the device as a result of a negative pressure within a fluid collection device, in other embodiments, the devices described herein can be used with any suitable device configured to establish a pressure differential (e.g., a negative pressure differential). For example, in some embodiments, an outlet of a control device can be coupled to a syringe or pump. In other embodiments, a control device can include a pre-charged sequestration chamber, a vented sequestration chamber, a manually activated device configured to produce a negative pressure, an energy source (e.g., a chemical energy source, a kinetic energy source, and/or the like), and/or any other suitable means of defining and/or forming a pressure differential within a portion of the control device. Moreover, as described above, the control devices can be coupled to such collection devices by a user (e.g., doctor, nurse, technician, physician, etc.) or can be coupled or assembled during manufacturing. In some embodiments, pre-assembling a control device and a collection device (e.g., a sample container or syringe) can, for example, force compliance with a sample procurement protocol that calls for the sequestration of an initial amount of bodily fluid prior to collecting a sample volume of bodily fluid. 
     While some of the embodiments described above include a flow controller and/or an actuator having a particular configuration and/or arrangement, in other embodiments, a fluid control device can include any suitable flow controller and/or actuator configured to selectively control a flow of bodily fluid through one or more portions of the fluid control device. For example, while some embodiments include an actuator such as a diaphragm or the like having one or more seals arranged as an O-ring or an elastomeric over-mold, which is/are moved with the diaphragm and relative to a portion of the device (e.g., the inlet, the outlet, or any other suitable portion) when the diaphragm is transitioned or flipped from a first state to a second state, in other embodiments, a fluid control device can include one or more seals having any suitable configuration. For example, in some embodiments, a fluid control device can include one or more seals arranged as an elastomeric sheet or the like that is/are fixedly coupled to a portion of the control device. In such embodiments, a portion of an actuator such as a pin or rod extending from a diaphragm (see e.g.,  FIGS.  11  and  12   ) can extend through an opening defined in the one or more elastomeric sheets, which in turn, form a substantially fluid tight seal with an outer surface of the pin or rod. As such, when the actuator (e.g., diaphragm) is transitioned from a first state to a second state, the portion of the actuator (e.g., the pin or rod) can move through one or more of the elastomeric sheets. In other words, the portion of the actuator moves relative to the one or more elastomeric sheets, which in turn, remain in a substantially fixed position relative to the portion of the control device. In some embodiments, the removal or the portion of the actuator can allow a flow of fluid through the opening defined by the one or more elastomeric sheets that was otherwise occluded by the portion of the actuator. Accordingly, the one or more elastomeric sheets can function in a similar manner as any of the seals described herein. Moreover, in some embodiments, such an arrangement may, for example, reduce an amount of friction associated with forming the desired fluid tight seals, which in turn, may obviate the use of a lubricant otherwise used to facilitate the movement of the seals within the control device. 
     While the diaphragms (e.g., diaphragms  576 ,  676 , and  776 ) are described herein as being configured to transition, move, flip, and/or otherwise reconfigure in response to an amount of negative pressure exerted on a surface of the diaphragm exceeding a threshold amount of negative pressure, in other embodiments, a fluid control device can include any suitable actuator or the like configured to transition, move, flip, and/or otherwise reconfigure in response to being exposed to a desired and/or predetermined amount of negative pressure. For example, in some embodiments, a fluid control device can include an actuator including and/or arranged as a movable member, plug, plunger, occlusion member, seal, and/or the like configured to selectively control a flow of fluid through at least a portion of the fluid control device. More particularly, the movable member or the like can be transitioned from a first state and/or position in which the movable member or the like is disposed in and/or otherwise occludes an opening, to a second state and/or position in which the movable member or the like is removed from the opening. In such embodiments, a negative pressure can be exerted through a portion of the device to transfer, for example, an initial volume of bodily fluid into a sequestration portion and/or chamber. 
     As described in detail above, in some embodiments, a device can include a flow controller such as a selectively permeable member or membrane, that can be configured to transition from a first state to a second state in response to being wetted (or otherwise transitioned) by the initial volume of bodily fluid. After transferring the initial volume of bodily fluid and after the flow controller is transitioned to its second state, an amount of negative pressure exerted on a surface of the movable member or the like may build until a magnitude of the negative pressure is sufficient to pull or move the movable member out of the opening, thereby allowing a flow of bodily fluid through the opening that was otherwise occluded by the movable member. In this manner, the movable member can function similar to any of the diaphragms described herein (e.g., the diaphragm  576 ,  676 , and/or  776 ) that are configured to transition or flip from a first state to a second state. In such embodiments, the movable member can be, for example, an elastomeric plug, cork, plunger, and/or any other suitable member that can be moved or “popped” out of such an opening or portion of a flow path. 
     While some of the embodiments described above include a flow controller and/or actuator that selectively establishes fluid communication between a sequestration chamber and a fluid collection device (e.g., a sample reservoir, a syringe, and/or any other suitable source of negative pressure) in other embodiments, a control device can be arranged to transfer a flow of bodily fluid in response to negative pressure differentials resulting from any suitable portion(s) of the device. For example, while the control device  200  is described above as including the flow controller  242  and the restricted flow path  232  that selectively place the sequestration chamber  234  in fluid communication with the sample reservoir until the flow controller  242  is transitioned to a sealed or closed state (e.g., until the flow controller  242  is sufficiently wetted), in other embodiments, a control device can include a sequestration chamber that is a pre-sealed evacuated and/or charged chamber such that establishing fluid communication between an inlet and the sequestration chamber results in a negative pressure differential that is sufficient to draw an initial volume of bodily fluid into the sequestration chamber. In such embodiments, the control device can be configured to transfer bodily fluid to the sequestration chamber until the pressure differential is sufficiently reduced and/or until pressures otherwise substantially equalize. Moreover, in some such embodiments, the sequestration chamber and/or the inlet can include a coupler, an actuator, a needle, a septum, a port, and/or any other suitable member that can establish fluid communication therebetween (e.g., that can transition the sequestration chamber from a sealed to an unsealed configuration). 
     While some of the embodiments described above include a flow controller and/or actuator that physically and/or mechanically sequesters one or more portions of a fluid control device, in other embodiments, a fluid control device need not physically and/or mechanically sequester one or more portions of the fluid control device. For example, in some embodiments, an actuator such as the actuator  1250  can be transitioned from a first state in which an initial volume of bodily fluid can flow from an inlet to a sequestration chamber or portion, to a second state in which (1) the sequestration chamber or portion is physically and/or mechanically sequestered and (2) the inlet is in fluid communication with an outlet of the fluid control device. In other embodiments, however, an actuator and/or any other suitable portion of a fluid control device can transition from a first state in which an initial volume of bodily fluid can flow from an inlet to a sequestration chamber or portion, to a second state in which the inlet is placed in fluid communication with the outlet without physically and/or mechanically sequestering (or isolating) the sequestration chamber or portion. When such a control device is in the second state, one or more features and/or geometries of the control device can result in a preferential flow of bodily fluid from the inlet to the outlet and the initial volume of bodily fluid can be retained in the sequestration chamber or portion without physically and/or mechanically being sequestered or isolated. 
     While the restricted flow path  232  is described above as modulating and/or controlling a magnitude of negative pressure applied on or through at least a portion of the device  200 , in other embodiments, a control device can include any suitable feature, mechanism, and/or device configured to modulate, create, and/or otherwise control one or more pressure differentials through at least a portion of the control device. For example, in some embodiments, a user can transition and/or move an actuator to change (e.g., reduce or increase) the size of one or more portions of a fluid flow path or fluid flow interface within a portion of the control device to manually modulate and/or otherwise control an amount or magnitude of negative pressure within one or more portions of a control device. 
     Although various embodiments have been described as having particular features, concepts, and/or combinations of components, other embodiments are possible having any combination or sub-combination of any features, concepts, and/or components from any of the embodiments described herein. For example, as described above, the device  700  includes concepts, features, and/or elements of the devices  200  and  600 . As another example, any of the embodiments described herein can include a lock or other suitable feature configured to at least temporarily maintain one or more components in a desired position, state, arrangement, and/or configuration. As another example, any of the embodiments described herein can include and/or can define a sequestration chamber and/or portion that is configured similar to, for example, the sequestration chamber  1234  described above with reference to  FIG.  30   . In other words, any of the fluid control devices described herein can include a sequestration chamber that is arranged and/or formed as a channel. In some embodiments, a channel forming at least a portion of a sequestration chamber can have a relatively small cross-sectional shape and/or size that can reduce and/or substantially prevent mixing of air and bodily fluid as the initial volume of bodily fluid is drawn into the channel, as described above with reference to the sequestration chamber  1234 . Moreover, such a channel can have a spiral shape and/or configuration similar to the sequestration chamber  1234  described above and/or can have any other suitable shape and/or configuration. 
     As another example, any of the control devices described herein can include a flow controller arranged as a selectively permeable member or membrane as described above, for example, with reference to the flow controller  242 . More particularly, while the control device  600  is not described as including a flow controller, in other embodiments, a portion of the diaphragm  676  can include and/or can form a flow controller formed, at least in part, of a selectively permeable material. In such embodiments, the flow controller can be configured to allow a volume of the sequestration chamber and/or portion  634  to be vented in response to being exposed to the negative pressure differential (as described above). In other words, a volume of air can be drawn out of (e.g., vented from or purged from) the sequestration chamber  634  via the flow controller in response to the negative pressure differential within a portion of the fluid control device  600 . In some instances, such an arrangement can allow for a reduction in a size and/or volume of the sequestration chamber  634  because a volume of air otherwise occupying a portion of the sequestration chamber  634  is vented or purged through the flow controller in response to the negative pressure differential. 
     By way of another example, any of the embodiments described herein can include any suitable actuator and/or flow controller configured to selectively control fluid flow through at least a portion of the device. Specifically, a flow controller or the like can be one or more of a selectively permeable material or membrane, a valve, a diaphragm, and/or any other suitable flow controller. While some of the embodiments have been described as including an actuator rod configured to be transitioned from a first configuration or position to a second configuration or position (e.g., the actuator rod  1262  of the actuator  1250 ), in other embodiments, any actuator described herein can include an actuator rod configured to transition from between a first position and second position to at least temporarily isolate an outlet of the device from one or more other portions of the device (e.g., as described above with reference to the actuators  850  and/or  1350 ). In some embodiments, such an actuator can be configured for use with a given and/or predetermined collection device such as, for example, a syringe. In other embodiments, such an actuator can be used with any suitable collection device. 
     In some embodiments, the specific configurations of the various components can also be varied. For example, the size and specific shape of the various components can be different from the embodiments shown, while still providing the functions as described herein. For example, while a portion of the actuator body  1551 , sequestration chamber  1534 , and/or the bladder  1578  are shown in  FIGS.  45 - 50    as being substantially tubular having a round or substantially semi-circular end portion, in other embodiments, the portion of the actuator body  1551 , sequestration chamber  1534 , and/or bladder  1578  can have any suitable shape and/or size. In some embodiments, varying the size and/or shape of such components may reduce an overall size of the device  1500  and/or may increase the ergonomics of the device  1500  without changing the function of the device  1500 . As a specific example, a housing, sequestration chamber, and/or bladder may have a substantially cylindrical shape with a relatively flat end portion or the like. Moreover, in some embodiments, a control device can include a bladder that is configured to “flip” similar to the diaphragms described above in response to being exposed to a negative pressure differential. In other embodiments, a bladder can be configured to gradually transition (e.g., unroll, unfold, unfurl, and/or otherwise reconfigure) from the first state to the second state. In some instances, controlling a rate at which a bladder is transitioned may allow for a modulation and/or control of a negative pressure differential produced within the sequestration chamber. 
     In other embodiments, a device may include a bladder (similar in form and/or function to the bladders  1478  and/or  1578 ) disposed in a housing having a size, shape, and/or profile similar to the housings  1230  and/or  1330 . In some such embodiments, the bladder can define a volume that is similar in shape and/or size the overall size, and/or shape of the housing (e.g., cylindrical with a relatively low profile or height). In some instances, such an arrangement can allow at least a portion of an initial volume of bodily fluid to remain in contact with a surface of the bladder (or diaphragm or other actuator), which can provide a visual indication to the user regarding the bodily fluid being transferred into the sequestration chamber. In other embodiments, a housing similar to the housing  1230  can define a spiral channel or any other suitable channel and can include a bladder disposed within at least a portion of that channel. In such embodiments, the bladder can function similarly to the bladder  1578  in which the bladder expands, opens, and/or otherwise increases in volume in response to being exposed to a negative pressure differential. In some embodiments, a bladder can define an enclosed volume configured to receive an initial volume of bodily fluid. In other embodiments, the bladder and a portion of the housing (e.g., a surface defining the sequestration chamber and/or channel) can collectively define the volume configured to receive the initial volume of bodily fluid. In this manner, a fluid control device can include a bladder configured to conform to any suitable shape, feature, channel, and/or configuration of a housing in which it is disposed. In some embodiments, the size and shape of the various components can be specifically selected for a desired rate and/or volume of bodily fluid flow into a fluid reservoir. 
     In some embodiments, the size and/or shape of the various components can be specifically selected for a desired or intended usage. For example, in some embodiments, a device such as those described herein can be configured for use with or on seemingly healthy adult patients. In such embodiments, the device can include a sequestration chamber that has a first volume (e.g., about 0.5 ml to about 5.0 ml). In other embodiments, a device such as those described herein can be configured for use with or on, for example, very sick patients and/or pediatric patients. In such embodiments, the device can include a sequestration chamber that has a second volume that is less than the first volume (e.g., less than about 0.5 ml). Thus, it should be understood that the size, shape, and/or arrangement of the embodiments and/or components thereof can be adapted for a given use unless the context explicitly states otherwise. 
     Although not shown, any of the devices described herein can include an opening, port, coupler, septum, Luer-Lok, gasket, valve, threaded connecter, standard fluidic interface, etc. (referred to for simplicity as a “port”) in fluid communication with the sequestration chamber. In some such embodiments, the port can be configured to couple to any suitable device, reservoir, pressure source, etc. For example, in some embodiments, the port can be configured to couple to a reservoir, which in turn, can allow a greater volume of bodily fluid to be diverted and/or transferred into the sequestration chamber. In other embodiments, the port can be coupled to a negative pressure source such as an evacuated container, a pump, a syringe, and/or the like to collect a portion of or the full volume of bodily fluid in the sequestration chamber, channel, reservoir, etc. and use that volume of bodily fluid (e.g., the pre-sample volume) for additional clinical and/or in vitro diagnostic testing purposes. In other embodiments, the port can be configured to receive a probe, sampling tool, testing device, and/or the like that can be used to perform one or more tests (e.g., tests not sensitive to potential contamination) on the initial volume while the initial volume is disposed or sequestered in the sequestration chamber. In still other embodiments, the port can be coupled to any suitable pressure source or infusion device configured to infuse the initial volume of bodily fluid sequestered in the sequestration chamber back into the patient and/or bodily fluid source (e.g., in the case of pediatric patients, very sick patients, patients having a low blood volume, and/or the like). In other embodiments, the sequestration channel, chamber, and/or reservoir can be configured with the addition of other diagnostic testing components integrated into the chamber (e.g., a paper test) such that the initial bodily fluid is used for that test. 
     In still other embodiments, the sequestration chamber, channel, and/or reservoir can be designed, sized, and configured to be removable and compatible with testing equipment and/or specifically accessible for other types of bodily fluid tests commonly performed on patients with suspected conditions. By way of example, a patient with suspected sepsis commonly has blood samples collected for lactate testing, procalcitonin testing, and blood culture testing. All of the fluid control devices described herein can be configured such that the sequestration chamber, channel, reservoir, etc. can be removed (e.g., after receiving the initial volume of bodily fluid) and the bodily fluid contained therein can be used for these additional testing purposes before or after the subsequent sample is collected for microbial testing. 
     Although not shown, in some embodiments, a fluid control device can include one or more lumen, channels, flow paths, etc. configured to selectively allow for a “bypass” flow of bodily fluid, where an initial amount or volume of bodily fluid can flow from the inlet, through the lumen, cannel, flow path, etc. to bypass the sequestration chamber, and into the collection device. In some embodiments, the fluid control device can include an actuator having, for example, at least three states—a first in which bodily fluid can flow from the inlet to the sequestration chamber, a second in which bodily fluid can flow from the inlet to the outlet after the initial volume is sequestered in the sequestration chamber, and a third in which bodily fluid can flow from the inlet, through the bypass flow path, and to the outlet. In other embodiments, the control device can include a first actuator configured to transition the device between a first and second state, as described in detail above with reference to specific embodiments, and can include a second actuator configured to transition the device to a bypass configuration or the like. In still other embodiments, the control device can include any suitable device, feature, component, mechanism, actuator, controller, etc. configured to selectively place the fluid control device in a bypass configuration or state. 
     Any of the embodiments described herein can be used in conjunction with any suitable fluid transfer, fluid collection, and/or fluid storage device such as, for example, the fluid reservoirs described in the &#39;420 patent. In some instances, any of the embodiments described herein can be used in conjunction with any suitable transfer adapter, fluid transfer device, fluid collection device, and/or fluid storage devices such as, for example, the devices described in the &#39;510 Publication and/or any of the devices described in U.S. Patent Publication No. 2015/0246352 entitled, “Apparatus and Methods for Disinfection of a Specimen Container,” filed Mar. 3, 2015; U.S. Pat. No. 8,535,241 entitled, “Fluid Diversion Mechanism for Bodily-Fluid Sampling,” filed Oct. 12, 2012; U.S. Pat. No. 9,060,724 entitled, “Fluid Diversion Mechanism for Bodily-Fluid Sampling,” filed May 29, 2013; U.S. Pat. No. 9,155,495 entitled, “Syringe-Based Fluid Diversion Mechanism for Bodily-Fluid Sampling,” filed Dec. 2, 2013; U.S. Patent Publication No. 2016/0361006 entitled, “Devices and Methods for Syringe Based Fluid Transfer for Bodily-Fluid Sampling,” filed Jun. 13, 2016; U.S. Patent Publication No. 2018/0140240 entitled, “Systems and Methods for Sample Collection with Reduced Hemolysis,” filed Nov. 20, 2017; and/or U.S. Patent Publication No. 2017/0065733 entitled, “Apparatus and Methods for Maintaining Sterility of a Specimen Container,” filed Sep. 6, 2016, the disclosures of each of which are incorporated herein by reference in their entireties. 
     In some embodiments, a method of using a fluid control device such as those described herein can include the ordered steps of establishing fluid communication between a bodily fluid source (e.g., a vein of a patient or the like) and an inlet of a fluid control device. An outlet of the fluid control device is then placed in fluid communication with and/or otherwise engages a negative pressure source. Such a negative pressure source can be a sample reservoir, a syringe, an evacuated container, an intermediate transfer device, and/or the like. The fluid control device can be in a first state or operating mode when the outlet is coupled to the negative pressure source and, as such, a negative pressure differential is applied through the fluid control device that draws an initial volume of bodily fluid into a sequestration chamber of the fluid control device. For example, a negative pressure within a sample reservoir can be operable in drawing an initial volume of bodily fluid from a patient and into the sequestration chamber. Once the initial volume of bodily fluid is disposed in the sequestration chamber, the fluid control device is transitioned, either automatically or via user intervention, from the first state or operating mode to a second state or operating mode such that (1) the initial volume is sequestered in the sequestration chamber and (2) the fluid communication is established between the inlet and the outlet. The sequestration of the initial volume can be such that contaminants entrained in the flow of the initial volume are likewise sequestered within the sequestration chamber. With the initial volume of bodily fluid sequestered in the sequestration chamber and with fluid communication established between the inlet and the outlet, subsequent volumes of bodily fluid that are substantially free of contamination can be collected in one or more sample reservoirs. 
     While the method of using the fluid control device is explicitly described as including the recited ordered steps, in other embodiments, the ordering of certain events and/or procedures in any of the methods or processes described herein may be modified and such modifications are in accordance with the variations of the invention. Additionally, certain events and/or procedures may be performed concurrently in a parallel process when possible, as well as performed sequentially as described above. Certain steps may be partially completed or may be omitted before proceeding to subsequent steps. For example, while the devices are described herein as transitioning from a first state to a second state in a discrete operation or the like, it should be understood that the devices described herein can be configured to automatically and/or passively transition from the first state to the second state and that such a transitioning may occur over a period of time. In other words, the transitioning from the first state to the second state may, in some instances, be relatively gradual such that as a last portion of the initial volume of bodily fluid is being transferred into the sequestration chamber, the housing begins to transition from the first state to the second state. In some instances, the rate of change when transitioning from the first state to the second state can be selectively controlled to achieve one or more desired characteristics associated with the transition. Moreover, in some such instances, the inflow of the last portion of the initial volume can limit and/or substantially prevent bodily fluid already disposed in the sequestration chamber from escaping therefrom. Accordingly, while the transitioning from the first state to the second state may occur over a given amount of time, the sequestration chamber can nonetheless sequester the volume of bodily fluid disposed therein.