Patent Publication Number: US-2022226235-A1

Title: Topical copper ion treatments and methods of making topical copper ion treatments for use in various anatomical areas of the body

Description:
BACKGROUND OF THE INVENTION 
     Field of the Invention 
     The invention pertains generally to topical treatments containing copper ions and to methods of making topical treatments containing copper oils for use in treating conditions in various anatomical areas of the body. More particularly, the invention pertains to topical treatments containing copper ions and to methods of making such topical treatments wherein copper ions from copper metal are leached into a solution. 
     Brief Discussion of the Related Art 
     Many various abnormal body conditions are caused by harmful pathogens or microbes, examples of which include bacteria, fungi and viruses. Abnormal body conditions that arise in or affect the genital area in women typically affect the vagina and are commonly referred to as “vaginitis”. The term “vaginitis” encompasses infection and/or inflammation of the vagina caused by bacteria, fungi and/or viruses. Vaginitis may extend to the external female genital area, i.e. the vulva, in which case it is usually referred to as “vulvovaginitis”. In addition, bacterial, fungal and viral conditions that affect all or part of the genital area in women, i.e. vagina, vulva and/or surrounding anatomical area, may also affect all or part of the rectal (anal) area, i.e. the rectum (anal canal) and surrounding anatomical area. In men, infection and/or inflammation of bacterial, fungal and/or viral origins may affect all or part of the rectal area and also all or part of the genital area, i.e. the penis, scrotum and surrounding anatomical area. 
     Vaginitis that is bacterial in origin is commonly called “bacterial vaginosis”. Many different bacteria are responsible for bacterial vaginosis and some of these bacteria are the cause of sexually transmitted diseases in women and men. Examples of sexually transmitted bacterial diseases that affect the vagina and surrounding an areas are gonorrhea and chlamydia, which appear in the general population on a widespread basis. It is estimated by the Centers for Disease Control and Prevention (CDC) that more than 700,000 people annually in the U.S. alone acquire new gonorrhea infections. According to the CDC, over 1.3 million chlamydia infections were recorded in the U.S. in 2010 alone. In addition, there are a large number of undiagnosed, untreated or unreported infections of gonorrhea and chlamydia because the diseases may be asymptomatic or present with only very mild symptoms. Oftentimes, gonorrhea and chlamydia occur together. Gonorrhea and chlamydia may also appear in the mouth, throat and rectum (anus) in men and women. If left untreated, gonorrhea and chlamydia can spread to the uterus and/or Fallopian tubes and may cause pelvic inflammatory disease (PID) infertility, ectopic pregnancies, chronic pelvic pain and increased risk for infection with the human immunodeficiency virus (HIV). Untreated gonorrhea may also affect the blood, joints and heart valves. The usual treatments for gonorrhea and chlamydia are appropriate antibiotics, but history has demonstrated that over time many bacterial diseases develop a resistance to antibiotics. Indeed, according to the CDC, numerous antibiotics previously used to treat gonorrhea have lost their effectiveness, and there is currently only one remaining drug, i.e. the injectable antibiotic ceftriaxone, proven effective for treating gonorrhea. There is great concern in the medical community that it is only a matter of time before gonorrhea becomes resistant to this last remaining drug. Other types of pathogens and microbes, such as the bacteria streptococcus and staphylococcus and the parasitic protozoan trichomonas, may also affect the vagina and surrounding anatomical areas resulting in abnormal biological conditions. As with gonorrhea, staphylococcus infections are especially problematic because certain strains of the bacteria have become antibiotic resistant. Infections in the vagina may spread to the uterus, resulting in PID which is often a very painful and serious condition with potentially harmful and permanent complications. 
     In addition to being susceptible to abnormal body conditions caused by bacteria, the vagina and surrounding anatomical areas are susceptible to various abnormal body conditions caused by viruses and fungi. Viral diseases that arise in or affect the vagina and surrounding anatomical areas include herpes (Types I and II), human papilloma virus (HPV) and HIV, all of which are sexually transmittable. Herpes, HPV and HIV can also be found in the areas of the mouth, skin and rectum (anus). Fungal diseases that arise in or affect the vagina include yeast infections, particularly candida, and thrush. Fungi are also responsible for abnormal biological conditions in other areas of the body such as the mouth (thrush), feet, skin and nails. There is no cure for herpes and HIV. Anti-viral drugs are available to alleviate herpes symptoms and suppress the herpes virus so that active infections recur less frequently and are of shorter duration, but these drugs are associated with significant side effects. Infection with HPV is usually treated with topical medications, oral medications and/or surgical removal of warts. Complications of HPV infection include increased risk for cervical, rectal and vulvar cancers. Available treatments for HIV are designed to suppress the virus and boost the immune system in hope of avoiding opportunistic infections and delaying or preventing the onset of full-blown acquired immune deficiency syndrome (AIDS). In recent years, it was hoped that a vaginal microbicide gel called PRO 2000 would be effective at reducing HIV infection when used shortly before sexual intercourse, but unfortunately the compound was found to be ineffective in a large scale clinical trial. Topical and oral medications are available to treat yeast and other fungal infections but are limited in effectiveness such that fungal infections are often not eradicated and thus reoccur. The vast majority of abnormal body conditions caused bacteria, viruses and fungi that affect the genital and/or rectal areas in women also affect the genital and/or rectal areas in men. 
     In addition to conditions caused by harmful pathogens or microbes, hemorrhoids are another abnormal body condition that affects the rectum (anus) in men and women and may cause rectal pain, swelling, discomfort and/or itching. Conventional treatments for hemorrhoids include topical medications and surgery. In addition to harmful microbes and pathogens, sperm are microbes that appear in the vagina after intercourse. Numerous spermicidal contraceptive compounds are available for introduction in the vagina. Typically, these must be introduced in the vagina very shortly before intercourse and are therefore oftentimes inconvenient. When intercourse takes place without contraception and there is concern for an unwanted pregnancy, drugs known as the “morning after pill” or “emergency contraceptives” are sometimes prescribed to prevent pregnancy, but these drugs are not 100% effective and may have undesirable side effects. 
     Abnormal body conditions of bacterial, viral and fungal origins commonly arise in dermatological areas of the body, i.e. skin and nails. The skin and soft tissue are common sites for infections caused by various bacteria including staphylococcus, enterobacter, pseudomonas, and streptococcus. Oftentimes, infections develop on the skin at the site of a cut, scratch, abrasion, burn, splinter, boil, pimple, blister, insect bite or other wound or trauma that damages or breaks the skin or provides a point of entry for bacteria and/or other harmful organisms. Viruses such as herpes, shingles and HPV are also the cause of abnormal body conditions on the skin. In particular, herpes causes cold sores (fever blisters), shingles causes painful eruptions, and HPV causes warts on the skin. Other organisms also cause warts on the skin. The skin is susceptible to various fungal conditions, such as “athlete&#39;s foot” which commonly occurs on the feet and rashes such as ringworm. Infections of the nails, particularly fungal infections of the toenails, are also a common and tenacious problem. The skin is further susceptible to various body conditions resulting from aging, environmental factors and various external and internal causes, such conditions including sun/wind damage, dry skin, age spots, pigmentation, scarring, blisters, boils, cysts, pimples, cuts, scratches, burns, abrasions, splinters, insect bites and stings, animal bites and scratches, ulcers, loss of elasticity or collagen that manifests as winkles and sagging skin, acne, and many types of rashes, such as measles, chicken pox, eczema, psoriasis, impetigo and rosacea, due to various underlying external and internal causes. Various topical and oral prescription and non-prescription medications and products are available to treat the foregoing skin conditions. The skin is also a carrier for bacteria, viruses and fungi, seeing as how the skin regularly comes in contact with a plethora of pathogens and microbes. Consequently, many products such as sanitizing hand and body lotions and wipes are available commercially for the purpose of reducing germs on the skin. 
     The oral-respiratory-otic areas of the body, i.e. mouth, throat, nose, sinuses and ears are also common sites for abnormal body conditions due to the aforementioned pathogens and microbes. In addition, various allergies cause undesirable body conditions that impact the oral-respiratory-otic areas of the body, particularly the throat, nose and sinuses. Asthma is a chronic inflammatory disease of the airways responsible for undesirable conditions. Bacteria, viruses, fungi, allergies and/or asthma are responsible for many unwanted symptoms that appear in the oral-respiratory-otic areas of the body including sore throat, tonsillitis, colds, bronchitis, sinusitis, rhinosinusitis, wheezing, ear infections, earache, pressure in the ears, cold sore, mouth ulcers, canker sores, cough, hoarseness or laryngitis, congestion, runny nose, sneezing, sore gums, periodontal disease, tooth decay and halitosis (bad breath). A vast array of prescription and non-prescription drugs and products are commercially available to treat oral-respiratory-otic conditions. 
     The prescription drugs and even many of the non-prescription drugs or products used to treat the numerous body conditions described above have many drawbacks including undesirable or potentially harmful side effects, high risk of harm in the event of overdose or improper use, high cost, limited effectiveness, the need for close medical monitoring, and inconvenience. Moreover, there is presently no single compound or product to treat a wide range of body conditions affecting the genital-rectal areas that include the vagina, rectum (anus), and surrounding anatomical areas, oral-respiratory-otic areas that include the mouth, throat, airway, nose, sinuses and ears, and the dermatological areas that include the skin and nails, much less a non-pharmaceutical topical treatment that is safe, cost-effective, easy and convenient to use, and capable of being embodied in different forms depending on the intended anatomical area or areas of use. 
     It has previously been established that copper possesses properties by which it is capable of killing, neutralizing and preventing the growth of human pathogens. It is known that many bacteria identified as human pathogens cannot survive on surfaces of copper metal U.S. Pat. No. 8,135,466 B2 to Fuller et al discloses a joint prosthesis having an implant body with an external surface containing an antimicrobial metal where the antimicrobial metal may be copper. U.S. Patent Application Publications No. US 2012/0071807 A1 and No. US 2012/0089068 A1 to McClure, Jr. disclose wound dressings containing a metal-based antimicrobial agent where the metal-based antimicrobial agent may be a mixture of silver ions and copper ions. Devices having an external surface of copper metal for insertion in the vagina to treat abnormal biological conditions have been proposed by Applicants in U.S. patent application Ser. No. 12/157,823 filed Jun. 13, 2006 (abandoned), Ser. No. 13/317,230 filed Oct. 12, 2011, and Ser. No. 13/464,005 filed May 4, 2012, the entire disclosures of which are incorporated herein by reference. 
     Topical substances containing particles of copper or its alloys have been proposed for health support uses. A product called “MesoCopper®” sold by Purist Colloids, Inc. is a colloidal copper solution containing nano particles of copper for use on the skin to minimum the appearance of tine lines and wrinkles. Another version of the product is sold as an ingestible mineral supplement. Copper peptides for use on the skin are also commercially available and these require peptides, i.e. small fragments of protein that have an affinity for copper to which they bind very tightly, U.S. Pat. No. 7,716,915 B2 to Morariu discloses a topical composition containing, at a minimum, a lipoic acid, a carnitine and a carnosine, where the carnosine may be chelated to zinc or copper ions. The intended use for the topical composition is to improve the appearance of aged skin, U.S. Patent Application Publication No. US2008/0195033 A1 to Eagleson et al discloses use of a metal substance to treat diseases in the body. The metal substance is primarily a colloidal suspension and delivery of the substance to the body may require the use of electricity. Prior to the present invention, it has not been recognized to provide a simple solution containing copper ions for use as a topical treatment to be applied directly to anatomical tissue to treat body conditions and/or for use in conjunction with various carriers including creams, gels, lotions, foams, pastes, other solutions, suppositories, tampons, body wipes, wound dressings, skin patches and suture material to form topical treatments in which the carriers facilitate delivery of the copper ions to contact anatomical tissue depending on the anatomical area or areas of use on the body. 
     SUMMARY OF THE INVENTION 
     According to an aspect of the invention, a topical copper ion treatment is prepared by a process whereby copper ions from copper metal leach into a biocompatible solution. The copper metal in solid form is placed into the solution in a sealed vessel, and the sealed vessel is placed in an oven to heat or maintain the solution at a temperature equal or substantially equal to 37° Celsius for a predetermined period of time during which copper ions leach from the copper metal into the solution. After the period of time has expired, the solution is separated from the copper metal and constitutes a copper ion-containing solution that can be used as a copper ion treatment for topical application to anatomical tissue in various areas of the body to treat various body conditions. Preferably, the biocompatible solution is a saline solution and the copper metal is pure copper. A copper ion-containing solution obtained in accordance with a preferred process results in en amount of copper ions equal or substantially equal to 46 mg present in 7.44 ounces of the copper ion-containing solution. 
     The copper ion-containing solution can be combined with various carriers to facilitate application or delivery of the copper ion-containing solution to anatomical tissue in accordance with the anatomical area or areas of use. Suitable carriers include creams, lotions, gels, foams, pastes, other solutions, tampons, suppositories, body wipes, wound dressings, skin patches and suture material to obtain other forms of copper ion treatments. Various devices such as containers, bottles and tubes can be used to dispense the copper ion treatments in a manner best suited for the form of copper ion treatment and/or the intended anatomical area or areas of use. The copper ion treatments are particularly advantageous for use on anatomical tissue of the genital-rectal areas, the oral-respiratory-otic areas and the dermatological areas of the body. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a front view of a bottle containing a copper ion treatment and having a spray pump nozzle for dispensing the copper ion treatment. 
         FIG. 2  is a side view of a bottle containing a copper on treatment and having a spray pump nozzle with an elongate extension for dispensing the copper ion treatment. 
         FIG. 3  is a side view of a bottle containing a copper ion treatment wherein the bottle is squeezable to dispense the copper ion treatment from a dropper on the bottle. 
         FIG. 4  is a side view of a bottle containing a copper ion treatment and having a brush for applying the copper ion treatment to an tissue. 
         FIG. 5  is a side view of a tube containing a copper ion treatment wherein the tube is squeezable to dispense the copper ion treatment. 
         FIG. 6  is a side view of an alternative battle that is squeezable to dispense a copper ion treatment and showing the bottle in a closed condition. 
         FIG. 7  is a side view of the bottle of  FIG. 6  showing the bottle in an open condition. 
         FIG. 8  is a side view of a bottle containing a copper ion treatment and having a pump nozzle for dispensing the copper ion treatment in the form of foam. 
         FIG. 9  is a side view of an applicator for delivering a copper ion treatment to the vagina. 
         FIG. 10  is a side view of the applicator of  FIG. 9  showing use of the applicator in conjunction with the tube of  FIG. 5 . 
         FIG. 11  is a side view of an alternative applicator for applying copper ion treatment onto anatomical tissue. 
         FIG. 12  is a side view of a tampon having a tampon body used as a carrier to deliver a copper ion treatment to the vagina. 
         FIG. 13  is a broken front view of a plurality of suppositories containing a copper on treatment, the suppositories being insertable in the vagina or rectum to deliver the copper ion treatment to the vagina or rectum. 
         FIG. 14  is a side view showing a suppository of  FIG. 13  being removed from its package. 
         FIG. 15  is a side view of an applicator for delivering the suppositories of  FIG. 13  to the vagina or rectum. 
         FIG. 16  is a front view of a package containing a body wipe carrying a copper ion treatment and showing the package partially open to remove the body wipe therefrom. 
         FIG. 17  is a perspective view of a wound dressing supplied with a copper ion treatment. 
         FIG. 18  is a plan view of a skin patch carrying a copper ion treatment. 
         FIG. 19  is a perspective view of sutures created in anatomical tissue using suture material carrying a copper ion treatment. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     A solution maintaining copper ions, i.e. copper ion-containing solution, for use as a topical treatment containing copper ions, i.e. topical copper ion treatment, to treat body conditions is produced according to a process or method by which copper ions from copper metal are leached into an appropriate biocompatible solution. As used herein, “copper metal” means pure copper (99.5% or greater copper after processing) and copper alloys such as brasses, bronzes, copper-nickels and copper-nickel-zincs. Preferably, pure copper is used as the copper metal. Example 1 describes the steps involved in producing an amount of copper ion-containing solution equal or substantially equal to 7.44 ounces. 
     EXAMPLE 1 
     7.44 ounces of biocompatible saline solution buffered with acetic acid and sodium acetate to a pH of 5 (±0.4) is placed in a container or vessel with a tight, removable lid to minimize evaporation. The container is placed in an incubator or oven at a temperature of 37° Celsius (±1° C.). When the saline solution has reached 37° Celsius, 102 grams of pure copper metal in solid form is placed in the heated solution within the container, and the container with the tight lid thereon is placed in the incubator at 37° Celsius for 24 hours. During the 24 hour period, copper ions from the copper metal leach into the solution. At the end of the 24 hour period, the container is removed from the incubator and the copper metal is removed or separated from the solution. The amount of solution remaining after removal or separation of the cooper metal therefrom constitutes the copper ion-containing solution and should be essentially 7.44 ounces with minimal evaporation. The copper ion-containing solution produced according to this process contains copper ions an amount equal or substantially equal to 46 milligrams when analyzed for copper content by inductively coupled plasma/optical emission spectroscopy (ICP/OES). The copper ion-containing solution is stored at room temperature and is ready for use it this form as a topical copper ion treatment to be applied to anatomical tissue to treat body conditions. In addition, the copper ion-containing solution is ready for use in conjunction with various carriers including creams, gels, lotions, foams, pastes, other solutions, suppositories, tampons, body wipes, wound dressings, skin patches and suture materials to form topical copper ion treatments in which the carriers facilitate delivery of the copper, ion treatments to contact anatomical tissue to treat body conditions. 
     The solid pure copper metal in Example 1 may be in the form of one or more sheets of pure copper metal, typically in the range of 0.03 to 0.06 inch thick, of appropriate length and width to provide the 102 grams of pure copper metal. In practice, the process described in Example 1 has been carried out using as the copper metal four vaginal therapeutic devices made of pure copper in accordance with Applicants&#39; prior patent application Ser. No. 13/464,005 previously incorporated herein by reference in its entirety. In this case, each vaginal therapeutic device used was 3.25 inches long by 0.750 inch wide with a wall thickness of 0.031 inch providing 25.5 grams of pure copper. The biocompatible saline solution used in the process described in Example 1 is commercially available from B. Braun Medical. As an alternative to the biocompatible saline, vaginal simulating fluid (VSF) buffered with acetic acid to a pH of 5 (±0.4) can be used as the biocompatible solution, but will produce less leaching of copper ions from copper metal over the 24 hour period. The VSF can be prepared in accordance with published literature, e.g. Owen, D. H., Katz, D. F., “A Vaginal Fluid Simulant”, Contraception, pages 94-95 (1999). The process described in Example 1 can be modified to eliminate the step of heating the solution prior to placement of the copper metal therein. In the latter case, the copper metal and unheated solution are placed in the container, the container with the tight lid thereon is placed in the incubator at 37° Celsius and, once the solution has reached 37° Celsius, the container with the heated solution and copper metal therein is allowed to remain in the oven for 24 hours. The copper metal can be removed or separated from the solution in various ways, such as by lifting the metal out of the solution or pouring the solution alone into another container. Of course, the quantities of biocompatible saline and solid copper mental used in Example 1 can be proportionately increased to produce a greater amount of copper ion-containing solution with each process. 
     The copper ion-containing solution is believed to have the greatest effectiveness for treating a wide range of body conditions when the solution contains the amount of copper ions leached into the saline from the copper metal over a 24 hour period as described in Example 1. However, it should be appreciated that the process described in Example 1 can be modified to obtain lower copper ion concentrations by adjusting the length of time that the container containing the heated saline and copper metal is allowed to remain in the incubator or oven as explained below in Examples 2, 3 and 4. 
     EXAMPLE 2 
     Follow the steps of Example 1 but allow the container containing the saline and copper metal to remain in the oven at 37° C. for one hour to obtain a copper ion-containing solution that contains an amount of copper ions equal or substantially equal to 8.8 mg. 
     EXAMPLE 3 
     Follow the steps of Example 1 but allow the container containing the saline and copper metal to remain in the oven at 37° C. for eight hours to obtain a copper ion-containing solution that contains en amount of copper ions equal or substantially equal to 22 mg. 
     EXAMPLE 4 
     Follow the steps of Example 1 but allow the container containing the saline and copper metal to remain in the oven at 37° C. for 72 hours to obtain a copper ion-containing solution that contains an amount of copper ions equal or substantially equal to 35 mg. 
     The copper ion-containing solution in its original form, i.e. at the end of the processes of Examples 1-4, can be applied directly to anatomical tissue in various anatomical areas of the body as a copper ion treatment to treat various body conditions. Many types of containers or bottles can be used to hold a quantity of the copper ion-containing solution and to dispense or apply the copper ion-containing solution to anatomical tissue in accordance with the intended anatomical area or areas of use. The copper ion-containing solution may also be used in conjunction with various carriers including creams, lotions, gels, foams, pastes, other solutions, tampons, suppositories, body wipes, wound dressings such as band aids and pads, skin patches and suture material to form copper ion treatments that facilitate delivery or application of the copper ion-containing solution, and therefore the copper ions, to anatomical tissue. Creams, lotions, gels, foams a pastes may be used when it is advantageous to alter the consistency of the copper toil-containing solution from its original form to obtain a thicker copper ion treatment to facilitate its delivery or application to anatomical tissue. As a result of the copper ions contacting anatomical tissue when the copper ion treatments are applied thereto, local and systemic therapeutic effects are realized including antibacterial, antimicrobial, antiseptic, antifungal, antiviral, anti-pathogenic, anti-inflammatory, spermicidal neutralization of free radicals, promotion of healing and tissue repair, prevention of biofilm, and immune-boosting effects. In particular, these effects are realized when the copper ion treatments are used on anatomical tissue in the genital-rectal areas, the oral-respiratory-otic areas and the dermatological areas of the body since the anatomical tissue in these areas is favorable for local and systemic delivery of drugs and medicaments. 
     In accordance with an aspect of the present invention the copper ion-containing solution is combined with an appropriate topical cream base to form a copper ion-containing cream, i.e. copper ion cream in which the amount of copper ion-containing solution is preferably in the range of 5% to 30% by weight of the total weight of the copper ion cream. Examples 5, 6, 7 and 8 pertain to copper ion creams made in accordance with this aspect of the invention using the copper ion-containing solution of Example 1. 
     EXAMPLE 5 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical cream base to form a copper ion cream in which the copper ion-containing solution constitutes 5 percent of the total weight of the copper ion cream. 
     EXAMPLE 6 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical cream base to form a copper ion cream in which the copper ion-containing solution constitutes 10 percent of the total weight of the copper ion cream. 
     EXAMPLE 7 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical cream base to form a copper ion cream in which the copper ion containing solution constitutes 20 percent of the total weight of the copper ion cream. 
     EXAMPLE 8 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical cream base to form a copper ion cream in which the copper ion-containing solution constitutes 30 percent of the total weight of the copper ion cream. 
     Various topical cream blues can be used as the carrier for the copper ion-containing solution in order to form the copper ion creams of Examples 5, 6, 7 and 8. One suitable topical cream base that can be used is VersaBase® cream made by Professional Compounding Centers of America (PCCA) of Houston, Tex. Another suitable topical cream base that can be used in the copper ion creams is Vanicream® made by Pharmaceutical Specialties, Inc. of Rochester, Minn. The copper ion creams are effective against the body conditions being treated when the only active ingredient in the copper ion creams directed at the underlying condition is the copper ion-containing solution. However, the copper ion creams could contain other ingredients added to the topical meant base that are not active ingredients with respect to the underlying condition being treated such as preservatives, penetrating additives, bioadhesives and stability aids. Preferably, a total weight of at least 70 grams, more preferably 80 grams, of the copper on creams in the various strengths, i.e. 5 percent, 10 percent, 20 percent and 30 percent of copper ion-containing solution relative to the total weight of the copper ion cream, will be provided for use in containers, bottles, or tubes from which the copper ion creams can be dispensed. It should be appreciated that copper ion creams can be made using the alternative copper ion-containing solutions described above. 
     According to a further aspect of the present invention, a topical copper ion treatment in the form of a copper ion-containing gel, i.e. copper ion gel, is composed of the copper ion-containing solution and a suitable topical gel base as illustrated below by Examples 9, 10, 11 and 12, which utilize the copper ion-containing solution of Example 1. The amount of the copper ion-containing solution in the copper ion gel is preferably in the range of 5% to 30% by weight of the total weight of the copper ion gel. 
     EXAMPLE 9 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical gel base to form a copper ion gel in which the copper ion-containing solution constitutes 5 percent of the total weight of the copper ion gel. 
     EXAMPLE 10 
     An appropriate amount of copper ion-containing solution is combined with biocompatible topical gel base to form a copper ion gel in which the copper ion-containing solution constitutes 10 percent of the total weight of the copper ion gel. 
     EXAMPLE 11 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical gel base to form a copper ion gel in which the copper ion-containing solution constitutes 20 percent of the total weight of the per ion gel. 
     EXAMPLE  12   
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical gel base to form a copper ion gel in which the copper ion-containing solution constitutes 30 percent of the total weight of the copper ion gel. 
     Various topical gel bases can be used as a carrier for the copper ion-containing solution in order to form the copper ion gels. An example of a suitable topical gel base that can be used in Examples 9-12 is VersaBase® gel made by PCCA. As explained above for the copper on creams, the copper ion gels will be effective when the only active ingredient in the copper ion gels is the copper ion-containing solution, but other ingredients that are inactive with respect to the underlying condition being treated can be added to the topical cream gels. Preferably, a total weight of at least 70 grams, more preferably 80 grams, of the copper ion gels in the various strengths, i.e. 5 percent, 10 percent, 20 percent and 30 percent of copper ion-containing solution relative to the total weight of the copper on gel, is provided for use in containers, bottles or tubes from which the copper ion gels can be dispensed. Also, copper ion gels can be made using the alternative copper ion-containing solutions. Copper ion gels can be made having a thin, fluidic consistency, and such gels may be used as copper ion serums. 
     A topical copper ion treatment in the form of a copper ion-containing lotion, i.e. copper ion lotion, according to an additional aspect of the invention is composed of the copper ion-containing solution and a suitable topical lotion base as represented by Examples 13, 14, 15 and 16. Examples 13-16 employ the copper ion-containing solution of Example 1, but copper ion lotions could be made using the alternative copper ion-containing solutions. The amount of the copper ion-containing solution in the copper ion lotion is preferably in the range of 5% to 30% by weight of the total weight of the copper ion lotion. Copper ion gels can be made having a thin fluidic consistency, and such gels may be used as copper ion serums. 
     EXAMPLE 13 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical lotion base to form a copper ion lotion in which the copper ion-containing solution constitutes 5 percent of the total weight of the copper ion lotion. 
     EXAMPLE 14 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical lotion base to form a copper ion lotion in which the copper ion-containing solution constitutes 10 percent of the total weight of the copper ion lotion. 
     EXAMPLE 15 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical lotion base to form a copper ion lotion in which the copper ion-containing solution constitutes 20 percent of the total weight of the copper ion lotion. 
     EXAMPLE 16 
     An appropriate amount of copper ion-containing solution is combined with biocompatible topical lotion base to form a copper ion lotion in which the copper ion-containing solution constitutes 30 percent of the total weight of the copper ion lotion. 
     Various topical lotion bases can be used as a carrier for the copper ion-containing solution in the copper ion lotions of Examples 13-16. One suitable topical lotion base that can be used is VersaBase® lotion made by PCCA. As explained above for the copper ion creams and gels, the copper ion lotions will be effective against the body conditions being treated when the only active ingredient in the copper ion lotions is the copper ion-containing solution, but other inactive ingredients could be added to the topical lotion base. Preferably, a total weight of at least 70 grams, more preferably 80 grams, of the copper ion lotions in the various strengths, i.e. 5 percent, 10 percent, 20 percent and 30 percent of copper ion-containing solution relative to the total weight of the copper ion lotion, will be provided for use in containers, bottles or tubes from which the copper ion lotions can be dispensed. 
     According to another aspect of the present invention, a topical copper ion treatment in the form of a copper ion-containing foam, i.e. copper ion foam, is composed of the copper ion-containing solution and a suitable foam base. Examples 17, 18, 19 and 20 set forth below pertain to copper on foams or foamable solutions made in accordance with this aspect of the invention using the copper ion-containing solution of Example 1, however copper ion foams or foamable solutions can be made using the alternative copper ion-containing solutions. The amount of the copper ion-containing solution in the copper ion foam or foamable solution is preferably in the range of 5% to 30% by weight of the total weight of the copper ion foam or foamable solution. 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical foam base to form a copper ion foam or foamable solution in which the copper ion-containing solution constitutes 5 percent of the total weight of the copper ion foam or foamable solution. 
     EXAMPLE 18 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical foam base to form a copper ion foam or foamable solution in which the copper ion-containing solution constitutes 10 percent of the total weight of the copper ion foam or foamable solution. 
     EXAMPLE 19 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible to foam base to form a copper ion foam or foamable solution in which the copper ion-containing solution constitutes 20 percent of the total weight of the copper ion foam or foamable solution. 
     EXAMPLE 20 
     An appropriate amount of copper ion-containing solution is combined with a biocompatible topical foam base to form a copper ion foam or foamable solution in which the copper ion-containing solution constitutes 30 percent of the total weight of the copper ion foam or foamable solution. 
     Various topical foam bases can be used as a caller for the copper ion-containing solution in order to form the copper ion foams or foamable solutions. Depending on the foam base used in Examples 17-20, the combination of foam base and copper ion-containing solution may be in the form of a foam. Alternatively, some foam bases that may be used will result in a foamable solution when combined with the copper ion-containing solution, and the foamable solutions will typically require an appropriate dispenser to create the actual foam. An example of a suitable topical foam base that can be used is VersaBase® foam made by PCCA. When using VersaBase® as the foam base in Examples 17-20, a foamable solution is obtained and requires a foam dispenser to create the foam. As explained above for the copper ion creams, gels and lotions, the copper ion foams will be effective against the body conditions being treated with the only active ingredient therein being the copper ion-containing solution. However, other ingredients that are inactive with respect to the condition being treated can be added to the topical foam base. It is preferred that a total weight of at least 70 grams, more preferably 80 grams, of the copper ion foams or foamable solutions in the various strengths, i.e. 5 percent, 10 percent, 20 percent and 30 percent of copper ion-containing solution relative to the total weight of the copper ion foam or foamable solution, be provided in dispensers from which the copper ion foams can be dispensed. 
     According to a further aspect of the invention, a topical copper ion treatment in the form of a copper ion-containing paste, i.e. copper ion paste, is composed of the copper ion-containing solution and a suitable paste base. Example 21 set forth below pertains to a copper ion toothpaste made in accordance with this aspect of the invention using the copper ion-containing solution of Example 1, but copper ion pastes can also be made using the alterative copper ion-containing solutions. The amount of the copper ion-containing solution in the copper ion pastes is preferably in the range of 5% to 30% by weight of the total weight of the copper on paste. 
     EXAMPLE 21 
     An appropriate amount of copper ion-containing solution is combined with a toothpaste base material to form a copper on toothpaste in which the copper ion-containing solution constitutes in the range of 5 percent to 30 percent of the total weight of the copper on toothpaste. 
     The toothpaste base material used in Example 21 can be a commercially available toothpaste including any of the toothpastes marketed and sold under the major brand names. A toothpaste made in accordance with Example 21 is advantageous for treating bad breath, sore gums, gum disease and tooth decay when used on a daily basis in place of a person&#39;s regular toothpaste. 
     According to a further aspect of the invention, the copper ion-containing solution can be combined with various base solutions to form alternative copper ion solutions. Example 22 set forth below pertains to a copper ion mouthwash made in accordance with this aspect of the invention using the copper ion-containing solution of Example 1, but copper ion solutions can also be made using the alternative copper ion-containing solutions of Examples 2-4. The amount of copper ion-containing solution in the alternative copper ion solution is preferably in the range of 5% to 30% by weight of the total weight of the copper ion solution. 
     EXAMPLE 22 
     An appropriate amount of copper ion-containing solution is combined with a mouthwash base solution to form a copper ion mouthwash in which the copper ion-containing solution constitutes in the range of 5 percent to 30 percent of the total weight of the copper ion solution. 
     The mouthwash base solution used in Example 22 can be a commercially available mouthwash including any of the mouthwashes marketed and sold under the major brand names. A mouthwash made in accordance with Example 22 is advantageous for treating bad breath, sore gums, periodontal disease and tooth decay when used on a daily basis. 
     The examples described above pertaining to carriers in the nature of lotions, gels, foams and other solutions are particularly well suited for creating copper ion treatments in the nature of copper ion soaps by using as carriers lotion, gel, foam or other solution bases containing a soap component. The copper ion soaps could be designed for use as body soaps or as dish soaps. 
       FIG. 1  depicts a device  10  useful for dispensing the copper ion treatments, particularly the copper ion-containing solutions in their original form, e.g. the form resulting from Examples 1-4, and the copper ion lotions. The device  10  comprises a container or bottle  12  for holding the copper ion-containing solution and having a spray pump nozzle  14  with an outlet orifice  16 . The spray pump nozzle  14  is resiliently biased, typically by a spring, in an upward direction away from the container  12  but is depressible in a downward direction toward the container  12  to effect the spray pump action. Each time the spray pump nozzle is manually depressed the full mount, typically using a finger of the hard holding the container, a predictable amount of copper ion-containing solution is discharged in the form of a spray or stream from the outlet orifice  16 . The container  12  may include a removable protective cover  18  for being disposed over the spray pump nozzle  14  between uses. In use, the outlet orifice  16  is placed in line with anatomical tissue to be treated at a close enough distance that the tissue is within the range of the spray or stream dispensed from the outlet orifice. The spray pump nozzle  14  is then depressed the full amount using a finger, causing the predictable amount of copper ion-containing solution to be delivered or sprayed onto the anatomical tissue. The spray pump nozzle  14  can, of course, be depressed multiple times to deliver multiple sprays or streams of the copper ion-containing solution to the tissue. The device  10  would also be adapted to dispense the copper ion lotions in a similar manner, although in such case the copper ion lotions would typically be dispensed in the form of a ribbon, mass or stream of material. In the latter case, the copper ion lotions could be dispensed directly on the tissue to be treated, or on the palm or fingers of a hand which is then used to apply the lotions on the tissue to be treated. The copper ion lotions may be best suited for use on the skin, on the external genital and rectal areas, and in the vagina. 
     Another device  20  useful for dispensing the copper ion treatments, particularly the copper ion-containing solution in its original form, is shown in  FIG. 2 . The device  20  is similar to the devices  10  and comprises a container or bottle  22  having a spray pump nozzle  24  with an outlet orifice  26 . The device  20 , however, further includes an elongate hollow extension  28  attached to the spray pump nozzle  24 . The extension  28  has a first end coupled with the outlet orifice  26  of the spray pump nozzle  24  and has an opposed second end with a wider end surface having a discharge opening  29 . Preferably, a plurality of discharge openings  29  are provided along the wider end surface as shown in dotted lines in  FIG. 2  to obtain a wider spray pattern as indicated by dotted lines. Each time the spray pump nozzle  24  is manually depressed the full amount, a predictable amount of copper ion treatment is released in spray form from the discharge openings  29  at the end of the extension  28 . The wider end surface and plurality of discharge openings at the second end of the extension provides a wider spray pattern than the device  10 . The device  20  could be designed without the spray pump nozzles with the container  22  being squeezable to force the copper ion treatment to be discharged from the discharge opening(s)  29 . The extension  28  may be selectively detachable/attachable to the spray pump nozzle  24  for ease of storage of the device  20 . The device  20  may include a removable protective cover (not shown) for being placed over the nozzle  24  between uses. The device  20  is particularly useful as an atomizer for dispensing the copper ion treatments to contact anatomical tissue deeper within the mouth, throat and airway. 
     The device  30  depicted in  FIG. 3  is also useful for dispensing the copper ion treatments, particularly the copper ion-containing solution in its original form. The device  30  comprises a squeezable container or bottle  32  for holding the copper ion treatment and having a tapered dropper or extension  34  with an outlet orifice  36  attached to a cap on the container  32 . In use, the container  32  is positioned so that the outlet orifice  36 , which is located at the tip of the dropper, faces anatomical tissue to be treated. The container  32  is then squeezed with the fingers and, in response to such finger pressure, individual drops of a predictable amount of copper ion treatment are released from the outlet orifice  36 . Alternatively, the extension  34  can be designed to discharge the copper ion treatment in the form of a spray as shown in dotted lines in  FIG. 3 , which would be particularly useful as a nasal/ear spray. The tapered configuration of the dropper/extension  34  facilitates its placement in the nostril (nasal cavity) and ear (ear canal). The container  32  may include a removable protective cover  38  for being disposed over the dropper  34  between uses. The device  30  is particularly useful for dispensing the copper ion treatments to contact anatomical tissue within the nose (nostrils), ears (ear canal), skin and nails. 
     An additional device  40  for dispensing the copper ion treatments is shown in  FIG. 4 . The device  40  comprises a container or bottler  42  for holding the copper ion treatment and having a removable cap  44  with a brush  45  attached to an underside of the cap. Typically, the cap  44  will be screwed onto a neck of the container  42 . When the cap  44  is disposed on the container  42 , the brush  46  extends into the container and is disposed within the copper ion treatment  43 . Upon removal of the cap  44  from the container  42 , the cap  44  may be manipulated using the fingers and hand to contact anatomical tissue to be treated with the brush  45  in order to deposit the copper ion treatment from the brush  45  onto the anatomical tissue. The device  40  would be particularly useful for applying the copper on treatments on the skin and nails. The brush  45  could be eliminated from the cap  44 , in which case the device  40 , if sized appropriately, would be advantageous for holding a copper on solution such as a copper ion mouthwash. 
     The device  50  illustrated in  FIG. 6  is particularly useful for dispensing the copper on treatments formed as creams, lotions, gels and pastes. The device.  50  comprises a container  52  in the form of a squeezable tube for holding the copper ion treatment and having a removable cap  54  disposed on an open end or neck  56  of the tube. Typically the cap  54  will be threaded onto an external thread  55  on the neck  56  of the tube. The cap  54  may optionally have a piercing formation  57  that may be used to puncture an optional seal covering the open neck  56  prior to the first use. Upon removal of the cap  54 , the piercing formation  57  is placed against the seal, and the cap  54  is pushed in the direction of the tube  52  to puncture the seal. Once the seal is penetrated, the tube  52  can be squeezed, preferably from the bottom of the tube working upward, causing the copper ion treatment to be dispensed from the open neck  56  of the tube. The device  50  is particularly well suited for dispensing the copper ion treatments onto the fingers or palm of a hand that is then used to apply the treatments to anatomical tissue, particularly the tissue of the skin and the external genital and rectal areas. However, the copper ion treatments could be squeezed directly on the anatomical tissue to be treated. In addition, when the copper ion treatment is in a paste or other suitable form for use as a toothpaste, the device  50  is particularly well suited for dispensing the copper ion treatment onto a tooth brush in a conventional manner. As explained further below, the device  50  is particularly well suited for use with a vaginal applicator. 
       FIGS. 6 and 7  depict an additional device  60  useful for dispensing the copper ion treatments. The device  60  is particularly advantageous for dispensing copper ion lotions. The device  60  comprises a container or bottle  62  for holding the copper ion treatment and having a cap  64  disposed on an open end or neck of the bottle. The cap  64  could be removable or non-removable. The top surface of the cap  64  is formed by a pivotable member or disc  65  having an outlet orifice  66  along a side edge thereof.  FIG. 6  depicts the cap  64  in its closed condition wherein the pivotable member  65  is in a horizontal position relative to the cap  64  and the outlet orifice  66  is disposed within the cap  64  and is not exposed. When the pivotable member  65  is depressed downwardly toward the container  62  at a location opposite the outlet orifice  66  as shown by the arrow in  FIG. 7 , the cap  64  will assume the open condition shown in  FIG. 7  wherein the pivotable member  65  is disposed at an angle relative to the cap  64  and the outlet orifice  66  is in an exposed position located slightly above the cap  64 . In use, the pivotable member  65  would be depressed using pressure applied with one or more fingers of the hand. With the cap  64  in the open condition as shown in  FIG. 7 , the container  62  can be squeezed manually to dispense the copper ion treatment therein from the outlet orifice  66 . The cap  64  is returned to the closed position by pressing downwardly on the pivotable member  66  at a location adjacent the outlet orifice. The device  60  is advantageous for dispensing the copper ion treatments onto the palm of the hand or fingers used to apply the treatment to anatomical tissue to be treated, but the device  60  could be used to dispense the copper ion treatments directly on the anatomical tissue to be treated. 
     The device  70  shown in  FIG. 8  is an example of a device that can be used to dispense the copper on treatment in the form of a copper ion foam. The device  70  comprises a container  72  for holding the copper ion foam or foamable solution and having a resiliently biased foam pump dispenser  74  with an outlet orifice  76 . When the foam pump dispenser  74  is depressed the full amount in a manner similar to the device  10 , a predictable amount of the copper ion foam is discharged through the outlet orifice  76 . If necessary, the device  70  may include a mechanism for creating foam as the copper ion treatment is discharged therefrom. The device  70  may have a removable protective cover  78  for being disposed over the foam pump dispenser  74  between uses. The device  70  could also be adapted to dispense copper ion lotions and gels. 
       FIG. 9  depicts a vaginal applicator  81  useful for delivering the copper ion treatments to the vagina. The vaginal applicator  81  is particularly useful in conjunction with the device  50  as depicted in  FIG. 10 . Also, the vaginal applicator  81  is particularly well suited for use when the copper ion treatments are in the form of either lotion, cream or gel. The vaginal applicator  81  comprises a hollow barrel  83  and a plunger  85  slidably mounted in the hollow barrel  83 . The barrel  83  has an open forward end defining a discharge openings  89  and has a rearward end wall through which a stem  91  of the plunger passes. The stem  91  is attached at one end thereof to an internal flange  93  disposed within the barrel in close, sealing relation therewith. The plunger has a finger flange  95  attached to an opposite end of the stem  91  that is disposed external of the barrel  83 , the flange  95  being engageable with a finger or fingers of a hand in order to selectively depress and withdraw the plunger  85  relative to the barrel  83 . For use with the device  50 , the forward end of the barrel  83  is provided with an internal thread  97  to threadedly engage with the external thread  55  on the neck  56  of the tube  52 . 
       FIG. 10  illustrates the vaginal applicator  81  being filled with the cooper ion treatment from the tube  52  of the device  50 . As seen in  FIG. 10 , the cap  54  is removed from the neck  56  of the tube  52 , and the forward end of the barrel  83  is threaded onto the neck  58  via threaded engagement of the threads  55  and  97 . At this stage, the plunger  85  is fully withdrawn relative to the barrel  83  such that the internal flange  93  is in abutment with the rearward end wall of the barrel  83 . The tube  52  is then squeezed using pressure from the fingers in order to dispense the copper ion treatment, represented at  98 , into the barrel  83  from the open neck  56  of the tube  52 . When the barrel  83  is sized for a particular dosage of copper ion treatment, a sufficient amount of copper ion treatment can be dispensed from the tube  62  to entirely fill the space within the barrel  83  from the neck of the tube  56  to the internal flange  93  which is in abutment with the rearward end wall of the barrel. Alternatively, an indicia or other marking  99  can be provided on the barrel  83  to indicate the point to which the barrel  83  should be filled with copper ion treatment  98  from the tube  52 . It is preferred that filling the space within the barrel from the neck of the tube to the internal flange corresponds to a dose of 5 grams of the copper ion treatment. Once the barrel  83  has been filled with the appropriate amount of copper ion treatment  98 , the barrel  83  is disengaged from the neck  56  of the tube  52  by disengaging the thread  97  from the thread  55 . In order to dispense the copper ion treatment  98  from the applicator  81 , the finger flange  95  of the plunger  85  is depressed toward the barrel  83  using a finger, thereby causing the internal flange  93  to push the copper ion treatment  98  through the discharge opening  89  as the plunger  85  is depressed relative to the barrel  83 . When the finger flange  95  meets the rearward end wall of the barrel  83 , the copper ion treatment  98  will be fully discharged from the applicator. It should be appreciated that the applicator  81  could be used in conjunction with other devices for supplying the copper ion treatments to the barrel  85 . It should also be appreciated that the applicator  81  can be supplied for use pre-filled with copper ion treatment  98 , in which case the forward end of the barrel would be provided with, a removable cap or seal. The applicator  81  is particularly advantageous for supplying the copper ion treatments to the vagina. Accordingly, prior to depressing the plunger  85  to discharge the copper ion treatment  98  from the barrel  83 , the forward end of the barrel  83  would be introduced into the vagina until the rearward end of the barrel was located near the entrance to the vagina. Then, upon depressing the plunger  85 , the copper ion treatment  98  is discharged from the discharge opening  89  into the vagina. 
     Another type of applicator useful in applying the copper ion treatments to anatomical tissue is shown at  101  in  FIG. 11 . The applicator  101  is in the nature of a swab comprising a handle  103  and a body of absorbent material  105  at are end of the handle  101 . The applicator  101  can be used in conjunction with a container or bottle containing a copper ion treatment, such as the device  40  of  FIG. 4 . Upon removal of the cap  44  from the bottle  42  of the device  40 , the handle  103  of the applicator  101  can be grasped with a hand used to manipulate the applicator  101  in order to dip the body of absorbent material  105  into the copper ion treatment within the bottle  42 . The body of absorbent material  105  can then be gently contacted with anatomical tissue to be treated thereby causing the copper on treatment carried by the absorbent body  105  to be deposited on the anatomical tissue to be treated. The applicator  101  is best suited for applying copper ion treatments to localized areas of the skin, nails, ear canal, nostrils, mouth and throat. Of course, it should be appreciated that swab applicators  101  can be provided in sealed packages with the bodies of absorbent material  105  pre-supplied with copper ion treatment. 
     Another type of earner that can be used to deliver copper ion treatments to the vagina is a tampon. The tampon used can be a commercially available tampon or one similar thereto. The tampon can be one having an applicator including a barrel containing the absorbent tampon body and a plunger slidable within the barrel to dispose or eject the absorbent tampon body from an open forward and of the barrel once the forward end has been introduced in the vagina an appropriate distance in a commonly known manner of tampon use. In this case, an appropriate amount of copper ion treatment can be supplied to the absorbent tampon body via the open forward end of the barrel prior to introduction of the applicator the vagina and ejection of the absorbent tampon body from the applicator into the vagina. Another suitable tampon can be one without an applicator, i.e. a digital tampon, where the absorbent tampon body is inserted in the vagina by pushing it with the fingers. In this case, the appropriate amount of copper ion treatment is simply deposited on the absorbent tampon body prior to its insertion in the vagina. In both cases, unless the tampon is going to be inserted in the vagina immediately or soon after the absorbent tampon body has been provided with the appropriate mount of copper ion treatment, the tampon should be stored in a sealed container or package until the time of its use in order to avoid evaporation of the copper ion treatment. It should be appreciated that tampon bodies to which the copper ion treatment has been supplied can be provided in sealed containers or packages, with or without an applicator, as a ready-to-use commercial product. Alternatively, the appropriate amount of copper ion treatment may be deposited by the user on the absorbent tampon bodies of tampons sold separately or in injunction with the copper ion treatment. Preferably, the tampon bodies are supplied with an amount of popper ion-containing solution in the range of 6 to 10 milliliters. 
       FIG. 12  illustrates a tampon  110  according to an aspect of the present invention including an applicator  111  having a hollow barrel  113  and a hollow plunger  115 , and an absorbent tampon body  118 , to which the appropriate amount of copper ion treatment has been supplied, disposed in the barrel  113  with the string  120  of the tampon body extending from a rear end of the plunger  115 . The plunger  115  is slidable within and toward the barrel  113  to push the tampon body  118  and eject it from an open forward end  128  of the barrel. The forward end  128  of the barrel  113  can be tapered to facilitate introduction and advancement in the vagina and can be provided with slits that expand as the tampon body  118  passes therethrough. The tampon  110  is provided in an air-tight container or bottle  122  having a removable cap or lid  124 . In order to use the tampon  110 , the lid  124  is removed from the bottle  122  and the tampon  110  is removed from the bottle. The tampon  110  is inserted in the vagina in a conventional manner of using tampons. More specifically, the applicator  111  is held by grasping a finger grip  126  on the barrel  113 , and the forward end  128  of the barrel is inserted in the vagina. The applicator  111  is advanced into the vagina until the fingers grasping the finger grip  126  touch the entrance to the vagina. The plunger  115  is then pushed into the barrel  113 , thus causing the tampon body  118  to be ejected from the forward end  128  of the barrel into the vagina. The applicator  111  is then withdrawn from the vagina and discarded, leaving the tampon body  118  in place in the vagina. Once the tampon body  118  is in place in the vagina, the copper to treatment carried by the tampon body contacts the anatomical tissue of the vagina and leaks into the vaginal fluid normally present in the vagina. The tampon body  118  is removed from the vagina at the appropriate time by grasping and pulling on the string  120 . Examples of tampons according to an aspect of the invention are described below in Examples 23 and 24. 
     EXAMPLE 23 
     A tampon for delivering a copper ion treatment to the vagina is prepared by supplying 5 milliliters of a copper ion-containing solution to an absorbent tampon body intended to be it into the vagina. 
     EXAMPLE 24 
     A tampon for delivering a copper ion treatment to the vagina is prepared by supplying 10 milliliters of a copper ion-containing solution to an absorbent tampon body intended to be introduced into the vagina. 
     The copper ion-containing solution used in Examples 23 and 24 is the copper ion-containing solution in its original form as obtained in accordance with the method set forth in Example 1. However, it should be appreciated that tampons can be provided in which the tampon bodies are supplied with the alternative copper ion-containing solutions or other forms of the copper ion treatments. 
     Another type of came useful to deliver the copper ion treatments to the vagina and rectum is a suppository. Suppositories are commonly used in the vagina and rectum (anus) as a means for dispensing various active ingredients or medicaments. Suppositories are made in various shapes including oviform, globular, conical and bullet shapes, and in various sizes. Suppositories typically weigh in the range of 1 to 5 grams. Suppositories can be solid bodies composed of a mixture of a suitable suppository base material and the active ingredients or medicaments. Alternatively, suppositories can be made with a solid outer wall of suppository base material enclosing non-solid active ingredients or medicaments. The suppository base materials used in suppositories allow them to dissolve or melt when exposed to the moisture (body fluid) or heat (body temperature) found in the vagina or rectum (rectal or anal canal), thereby releasing the active ingredients or medicaments into the vagina or rectum. Suitable suppository base materials in dude oleaginous (fatty) base materials, including was butter, theobroma oil and synthetic triglycerides, or water soluble or miscible base materials, including glycerinated gelatin and polyethylene glycol (PEG) polymers. It is preferred that the base materials be non-toxic, non-initiating, inert, and biocompatible. Suppositories suitable for use in an aspect of the present invention can be prepared in various ways according to conventional methods for preparing suppositories including compression molding and fusion molding. Suppositories for use as vaginal and rectal suppositories according to an aspect of the present invention are preferably made in two different sizes, i.e. a suppository weighing 3 grams and a suppository weighing 5 grams, to accommodate different sizes of vaginal and rectal anatomy. Each size suppository can be made in different strengths based on the percentage by weight of the active ingredient, i.e. the copper ion treatment, relative to the total weight of the suppository. Preferably, the amount of copper ion-containing solution in the suppository is in the range of 5% to 30% of the total weight of the suppository. The suppositories are preferably formed in plastic molds and can be stored at room temperature. The suppositories will be effective against the body condition being treated when the only active ingredient contained in the vaginal end rectal suppositories is the copper ion treatment. However, the vaginal and rectal suppositories could contain additional in that are inactive with respect to the underlying condition or conditions being treated, such as preservatives, penetrating additives, bioadhesives and stability aids. The suppositories may be inserted in the vagina and rectum using the fingers, or the suppositories may be provided with applicators to facilitate insertion thereof in the vagina and rectum. Examples of vaginal and rectal suppositories according to an aspect of the invention are set forth in Examples 25-32, which utilize the copper ion-containing solution of Example 1. However, the alternative copper ion-containing solutions could be used in Examples 25-32. 
     EXAMPLE 25 
     A suppository base material is combined with an appropriate amount of copper ion-containing solution and is molded into a suppository for vaginal or rectal use having a total weight of 3 grams, wherein the copper ion-containing solution constitutes 5 percent of the total weight of the suppository. 
     EXAMPLE 26 
     A suppository base material is combined with an appropriate amount of copper ion-containing solution and is molded into a suppository for vaginal or rectal use having a total weight of 3 grams, wherein the copper ion-containing solution constitutes 10 percent of the total weight of the suppository. 
     EXAMPLE 27 
     A suppository base material is combined with an appropriate mount of copper ion-containing solution and is molded into a suppository for vaginal or rectal use having a total weight of 3 grams, wherein the copper ion-containing solution constitutes 20 percent of the total weight of the suppository. 
     EXAMPLE 28 
     A suppository base material is combined with an appropriate amount of copper ion-containing solution and is molded into a suppository for vaginal or rectal use having a total weight of 3 grams, wherein the copper ion-containing solution constitutes 30 percent of the total weight of the suppository. 
     EXAMPLE 29 
     A suppository base material is combined with an appropriate amount of copper ion-containing solution and is molded into a suppository for vaginal or rectal use having a total weight of 5 grams, wherein the copper ion-containing solution constitutes 5 percent of the total weight of the suppository. 
     EXAMPLE 30 
     A suppository base material is combined with an appropriate amount of copper ion-containing solution and is molded into a suppository for vaginal or rectal use having a total weight of 5 grams, wherein the copper ion-containing solution constitutes 10 percent of the tot weight of the suppository. 
     EXAMPLE 31 
     A suppository base material is combined with an appropriate amount of copper ion-containing solution and is molded into a suppository for vaginal or rectal use having a total weight of 6 grams, wherein the copper ion-containing solution constitutes 20 percent of the total eight of the suppository. 
     EXAMPLE 12 
     A suppository base material is combined with an appropriate amount of copper ion-containing solution and is molded into a suppository for vaginal or rectal use having a total weight of 5 grams, wherein the copper ion-containing solution constitutes 30 percent of the total weight of the suppository. 
       FIG. 13  illustrates a strip  131  of interconnected packages or pods  132 , each enclosing a vaginal or rectal suppository  130  containing a copper ion treatment. The pods  132  are separated from each other by a perforation line  133  allowing the pods  132  to be detached from each other by tearing along the perforation tines  133  as depicted in  FIG. 13 . Each pod  132  has front and rear walls  135  between which a suppository  130  is retained. The front and rear walls  135  are sealed to, one another along their peripheral edges. As shown in  FIG. 14 , each pod  132  is provided with a pair of finger tabs  134  respectively attached to the front and rear walls  135 , the finger tabs  134  being capable of being pulled in opposite directions using the fingers to separate the opposed walls  135  and thereby release the suppository  130  contained therein. 
       FIG. 15  illustrates an applicator  181  suitable for use in delivering a suppository  130  to the vagina or rectum. The applicator  181  is similar to the applicator  81  but does not have an internal thread at the forward end of the bare  183 . In addition, the plunger  185  of the applicator  181  has two internal flanges  193   a  and  193   b  within the barrel  183 , the flange  193   a  controlling the distance that the plunger can be withdrawn relative to the barrel and the flange  193   b  serving to eject the suppository from the barrel when the plunger is depressed the full amount. In use, a suppository  130  is manually positioned in the open forward end of the barrel  183  as illustrated in  FIG. 15 . The open forward end of the barrel  183  is preferably sized to retain the suppository  130  in position without being overly snug or tight. The plunger  185  is withdrawn the full amount relative to the barrel  183 , which coincides with abutment of internal flange  193   a  with the rearward end wall of the barrel  183 . The forward end of the barrel  183  holding the suppository is then introduced in the vagina or rectal (anal) canal, and the applicator  181  is gently pushed into the vagina or rectal canal until the fingers holding the rearward end of the barrel  183  are adjacent or touch the entrance to the vagina or rectal canal. The finger flange  195  is then depressed to push the plunger  185  toward and into the barrel  183  as shown by the arrow in  FIG. 15 , thus causing the flange  193   b  to engage the suppository  130  and eject it from the forward end of the barrel into the vagina or rectal canal. The applicator  181  is then removed from the vain or rectal canal, leaving the suppository in the vagina or rectal canal. The suppository will melt or dissolve in the vagina or rectal canal such that the copper ion treatment is released to contact anatomical tissue of the vagina or rectal canal and to mingle with body fluid present in the vagina or rectal canal. 
     Another type of carrier that can be used to deliver the copper ion treatments to anatomical tissue is a body wipe.  FIG. 16  illustrates a body wipe  200  contained in a sealed package  202  having front and rear walls  203 . The body wipe  200  comprises thin sheet of material disposed a folded condition when retained between the front and rear walls  203 , which are sealed along their peripheral edges. The body wipe  200  enclosed between the front and rear walls  203  contains a wet or moist copper ion treatment. The front and rear walls  203  may be grasped by the fingers at corresponding corners thereof and pulled in opposite directions similar to the pods  132  in order to separate the front and rear wells  203  and thereby allow the body wipe  200  to be removed from the package  202 .  FIG. 16  shows the package  202  in a partially open condition in which corresponding corner sections of the front and rear wails  203  have been peeled away from one another thereby providing access to the body wipe  200 . Upon removal from the package  202 , the body wipe  200  can be unfolded to its full size, which is substantially larger than its size in the folded condition, and can be used to wipe anatomical tissue to be treated causing the copper ion treatment to be transferred to the anatomical tissue. The body wipe  200  is advantageous for applying the copper ion treatments to the skin and the external genital and rectal areas. 
     Another type of carrier for the copper ion treatments is a wound dressing, such as a band aid, gauze pad or similar device. Such carriers can be selected from products that are commercially available for removable application to the skin to temporarily cover and protect an affected area of the skin.  FIG. 17  depicts a carrier in the nature of a wound dressing  300  having a surface  301  for being placed in contact with the skin. The surface  301  includes a protective surface  302  for being positioned over a wound, and an adhesive border surrounding the surface  302 . In use, a copper ion treatment, such as the copper ion-containing solution in original form, can be liberally sprayed onto the surface  302  of the carrier that is applied adjacent or in contact with the skin. Then, when the surface  302  of the carrier is applied adjacent or in contact with the skin and the carrier is left in place on the skin for a period of time, the copper ions contact or are transferred to the skin and provide the therapeutic effects described above. Of course, it would be possible to provide carriers of this type in sealed packages in which the carriers are pre-supplied or pre-treated with the copper ion treatment similar to the body wipe  200 . 
     A further type of carrier for the copper ion treatments is a skin patch, such as a dermal patch or a transdermal patch, represented at  400  in  FIG. 18 . The skin patch  400  has a drug delivery surface  401  containing the copper ion treatment surrounded by an adhesive border  402 . The patch is applied to the skin and left in place for a period of time with the drug delivery surface in contact with the skin, causing the copper ions to diffuse through the skin where they can act locally or penetrate the capillaries for broader systemic effects. Examples of suitable transdermal patches are the transdermal and microneedle 3M Drug Delivery Systems manufactured by 3M Corporation. 
     An additional type of owner for the copper ion treatments is suture material, represented at  500  in  FIG. 19 , used by medical professionals to close or suture external or internal incisions or wounds, i.e. “stitches.” Prior to using the suture material  500 , which can be conventional suture material, the suture material can be soaked in the copper ion-containing solution for a period of time in order to cover or saturate the suture material with the solution. Suture material can also be stored in sealed packages containing the copper ion-containing solution. Then, when the suture material  500  is used to create sutures or stitches in anatomical tissue T as seen  FIG. 19 , the copper ions in the solution contact the anatomical tissue and provide the therapeutic effects previously described. 
     The copper ion-containing solution and the other forms of copper ion treatments described herein can be used on anatomical tissue in various areas of the body including the genital-rectal areas (vagina, vulva, penis, scrotum, rectum (anus), rectal (anal) canal and surrounding anatomical areas), the oral-respiratory-otic areas (mouth, throat, airway, nostrils and ears) and the dermatological areas (skin and nails) of the body. The treatment effects provided by the copper ion treatments encompass treatment of active or existing disease and other undesirable body conditions as well as the prevention of such diseases and conditions. The copper on treatments are especially beneficial for their ability to kill or neutralize harmful or undesired pathogens and microbes including bacteria, viruses and fungi. Although the copper on treatments are applied to to anatomical tissue and have a for effect on diseases and undesirable body conditions affecting the anatomical tissue, the copper ion treatments also have a broader systemic effect on diseases and undesirable body conditions. The effects realized with the copper ion treatments include antibacterial, antimicrobial, antiseptic, antifungal, antiviral, anti-pathogenic, anti-inflammatory, spermicidal, neutralization of free radicals, promotion of healing and tissue repair, prevention of and immuno-boosting effects. The diseases or conditions affecting the genital-rectal areas that are treatable with the copper ion treatments include vaginitis, bacterial vaginosis, hemorrhoids, vaginal dryness, imbalances in vaginal pH, bacterial infections caused by gonorrhea, chlamydia, streptococcus and staphylococcus, protozoan infections caused by trichomonas, pelvic inflammatory disease, viral infections caused by herpes (I and II), HPV and HIV, fungal infections caused by yeast, candida, thrush and other fungi, exposure to sexually transmitted diseases, and the risk of undesired pregnancy (contraception). The diseases or conditions affecting the oral-respiratory-otic areas that are treatable with the copper ion treatments include bacterial infections caused by gonorrhea, chlamydia, streptococcus and staphylococcus, protozoan infections caused by trichomonas, viral infections caused by herpes (I and II), HPV and HIV, canker sores, mouth sores, mouth ulcers, colds, sinusitis, rhinosinusitis, sore throat, nasal discharge, congestion, runny nose, bronchitis, allergies, asthma, tonsillitis, wheezing, sneezing, ear infections, earache, pressure in the ears, cough, hoarseness, laryngitis, sore gums, periodontal disease, bad breath and tooth decay. The diseases or conditions affecting the dermatological areas that are treatable with the copper ion treatments include bacterial infections caused by staphylococcus, streptococcus, enterobacter,  E. coli  and pseudomonas, viral infections caused by shingles, herpes (I and II) and HPV, fungal infections such as athlete&#39;s foot, ringworm and toenail fungus, impetigo, rosacea, psoriasis, eczema, warts, sun/wind damage, dry skin, age spots, pigmentation, scarring, blisters, boils, cysts, pimples, cuts, scratches, burns, abrasions, splinters, insect bites and stings, animal bites and scratches, ulcers, loss of elasticity or collagen, wrinkles, sagging skin, acne, measles, chicken pox, and the presence of pathogens and microbes on the skin that is an inevitable consequence of daily life. Based on the result of laboratory testing, it is expected that the copper ion treatments will kill bacteria causing bacterial vaginosis, gonorrhea and chlamydia, and the viruses responsible for herpes (I and II) and HIV at a kill rate of 99.99 percent in 6 hours. Accordingly, the copper ion treatments are sufficiently effective to “cure” the diseases and conditions described herein and to prevent the occurrence or development of such diseases and conditions. Similarly, copper has been demonstrated as having the capability to kill or render inactive staphylococcus, streptococcus, enterobacter, trichomonas,  E. coli  and pseudomonas. The copper ion treatments are highly effective at treating the various abnormal or undesired body conditions while being safe and non-toxic. In particular, copper toxicity is so rare that the World Health Organization (WHO) has determined that there is no need for setting an upper threshold for the ingestion of copper. The copper ion treatments can thus be safely used without concern for overdosing or improper use. Moreover, it is believed that, to date, no bacteria or other harmful microorganisms have been found to be capable of developing a resistance to copper, in contrast to the many bacteria and organisms that have developed or are in the process of developing resistance to conventional antibiotics. The multi-target effects of copper makes bacterial resistance extremely unlikely as copper kills bacteria very quickly and leaves almost no survivors. Consequently, them is neither the time for bacteria to learn how to resist the killing effect of copper or the possibility to pass on any knowledge to a significant population of survivors. The copper ion treatments provide a degree of efficacy and safety for treating a wide array of diseases and body conditions that far surpasses conventional pharmaceutical and non-pharmaceutical products and drugs available for treating the same conditions. 
     Inasmuch as the present invention is subject to many variations, modifications and changes in detail it is intended that all subject matter discussed above or shown in the accompanying drawings be interpreted as illustrative only and not be taken in a limiting sense.