Patent Publication Number: US-2022233616-A1

Title: Oncolytic virotherapy and immunotherapy

Description:
RELATED APPLICATIONS 
     This application is a national stage filing under 35 U.S.C. 371 of International Patent Application Serial No. PCT/EP2019/079123, filed Oct. 25, 2019, which claims priority from U.S. Application Ser. No. 62/750,402 filed Oct. 25, 2018. The contents and elements of each of which are herein incorporated by reference in their entirety. 
    
    
     SEQUENCE LISTING 
     The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on May 7, 2021, is named T082470021US00-SUBSEQ-AZW and is 467,042 bytes in size. 
     TECHNICAL FIELD 
     The present disclosure relates at least to the fields of cell biology, molecular biology, immunology, virology, and medicine, including cancer therapy. In particular embodiments the disclosure relates to combination treatments involving the use of oncolytic virotherapy and immunotherapy. 
     BACKGROUND 
     Oncolytic virotherapy for squamous cell carcinoma of the head and neck (HNSCC) HNSCC is the sixth leading cancer by incidence worldwide. Treatment of locally advanced, recurrent and metastatic HNSCC is often limited by an unfavorable efficacy to toxicity ratio and median survival for patients with metastatic disease remains less than one year (Zandberg and Strome, Oral Oncology (2014) 50: 627-632). Since HNSCC is a locoregional disease that presents at or close to the surface of the body, it is amenable to initial intratumoral injection of adenoviral vectors (Ads) to prompt a locoregional and even a systemic anti-tumor immune response (Liu et al., Nature Clinical Practice Oncology (2007) 4: 101-117). Several clinical trials of conditionally-replicating Ads (OncAds) or replication-deficient Ads encoding a therapeutic transgene have demonstrated the safety and feasibility of Ad gene therapy for HNSCC, but failed to show improved overall survival since intensive local treatment, even when combined with chemo/radiotherapy, did not prevent metastasis to distant sites (Liu et al., supra). OncAds are generally administered intratumorally, and poorly re-target to metastasized tumors (Koksi et al., Molecular Therapy: The Journal of the American Society of Gene Therapy (2015) 23:1641-1652). 
     OncAd with Helper-Dependent Ad (HDAd) Expressing Immunomodulatory Molecules 
     Adenoviral-based vectors (Ads) can infect a range of malignant cells and express high levels of lytic antigens and immunogenic transgenes, making them attractive as agents for cancer gene therapy (Cerullo et al., Advances in Cancer Research (2012) 115, 265-318). OncAds selectively replicate in cancer cells and are commonly used Ad-based vectors in clinical trials for cancer gene therapy. However, OncAds have a limited coding capacity for transgenes (˜1.5 kb). Helper-dependent Ads (HDAds) are devoid of viral coding sequences, enabling a cargo capacity of up to 34 kb for insertion of multiple transgenes in a single vector (Suzuki et al., Human Gene Therapy (2010) 21; 120-126). Since HDAd vector DNA encodes packaging signals, the OncAd replication machinery acts in trans to replicate and package both OncAd and HDAd within infected tumor cells, leading to multiple cycles of production and release of both the oncolytic virus and the transgenes encoded by the HDAd (combinatorial adenoviral vectors: CAd-VEC; Farzad et al., Molecular Therapy—Oncolytics (2014) 1, 14008). 
     CAR T-Cell Therapy 
     The use of T-cells as agents for cancer therapy has recently been facilitated by the expression of cancer cell antigen-directed chimeric antigen receptors (CARs; reviewed in Kershaw et al., Nature (2013) 13: 525-541). CAR-modified T-cells have shown promise for the treatment of hematological malignancies (Garfall et al., The New England Journal of Medicine (2015) 373:1040-1047), but have been less effective in treating solid tumors, which may in part be a consequence of the highly immunosuppressive nature of the solid tumor microenvironment (Quail et al., Nature Medicine (2013) 19:1423-1437). Due to immunosuppressive mechanisms at tumor site CAR T-cells fail to expand and persist long term despite the expression of one or two costimulatory endodomains. 
     Bispecific T Cell Engagers (BiTEs) 
     Bispecific T cell engagers are a class of antigen-binding molecule which are useful to enhance a subject&#39;s immune response to cells expressing given target antigen. BiTEs comprise an antigen-binding moiety specific for a target antigen connected via a linker to an immune cell surface protein (typically CD3). The BiTEs promote effector immune cell activity directed against cells expressing the target antigen by physically linking immune cells (T cells) to cells expressing the target antigen, thereby stimulating T cell activation, cytokine production and killing of the cell expressing the target antigen. BiTEs that target cancer cell antigens are reviewed e.g. in Huhels et al., Immunol Cell Biol. (2015) 93(3): 290-296. 
     The present disclosure provides a solution to a long-felt need for effective cancer therapies, including combinatorial cancer therapies. 
     BRIEF SUMMARY 
     In a first aspect, the present disclosure provides a combination of:
         (i) an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, or nucleic acid encoding said antigen-binding molecule; and   (ii) an oncolytic virus.       

     Also provided is a combination of:
         (i) an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, or nucleic acid encoding said antigen-binding molecule; and   (ii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen.       

     Also provided is a combination of:
         (i) an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, or nucleic acid encoding said antigen-binding molecule;   (ii) an oncolytic virus; and   (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen.       

     The present disclosure also provides a method of treating a cancer, comprising administering to a subject:
         (i) an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, or nucleic acid encoding said antigen-binding molecule; and   (ii) an oncolytic virus, and/or (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen.       

     In a related aspect, the present disclosure provides a combination of:
         (i) an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, or nucleic acid encoding said antigen-binding molecule; and   (ii) an oncolytic virus, and/or (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen, for use in a method of treating a cancer.       

     Also provided is the use of:
         (i) an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, or nucleic acid encoding said antigen-binding molecule; and   (ii) an oncolytic virus, and/or (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen, in the manufacture of a medicament for use in a method of treating a cancer.       

     In some embodiments the nucleic acid encoding the antigen-binding molecule is comprised within a virus. In some embodiments the virus encoding the antigen-binding molecule is a helper-dependent adenovirus (HDAd). 
     Also provided is a method of treating a cancer, comprising administering to a subject:
         (i) a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen; and   (ii) an oncolytic virus, and/or (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen.       

     Also provided is a combination of:
         (i) a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen; and   (ii) an oncolytic virus, and/or (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen, for use in a method of treating a cancer.       

     Also provided is the use of:
         (i) a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen; and   (ii) an oncolytic virus, and/or (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen, in the manufacture of a medicament for use in a method of treating a cancer.       

     In some embodiments in accordance with various aspects of the present disclosure the CAR and the antigen-binding moiety capable of binding to a cancer cell antigen are specific for non-identical cancer cell antigens. In some embodiments the antigen-binding molecule comprises (a) a heavy chain variable region (VH) and a light chain variable region (VL) specific for an immune cell surface molecule associated via a linker sequence to (b) VH and a VL specific for a cancer cell antigen. In some embodiments the immune cell surface molecule is a CD3-TCR complex polypeptide. In some embodiments the cancer cell antigen is selected from CD44v6, HER2, CD19, PSCA, p53, CEA, GP100, EGFR, hTERT, NY-ESO1, MAGE-A3, mesothelin and MUC-1. 
     In some embodiments the virus comprising nucleic acid encoding an antigen-binding molecule additionally comprises nucleic acid encoding an immunomodulatory factor which is an agonist of an effector immune response or an antagonist of an immunoregulatory response. In some embodiments the virus comprising nucleic acid encoding an antigen-binding molecule additionally comprises nucleic acid encoding IL-12 and/or an antagonist anti-PD-L1 antibody. In some embodiments the virus comprising nucleic acid encoding an antigen-binding molecule is a helper-dependent adenovirus (HDAd). In some embodiments the virus comprising nucleic acid encoding an antigen-binding molecule comprises nucleic acid encoding an enzyme capable of catalysing conversion of a non-toxic factor to a cytotoxic form. In some embodiments the enzyme is selected from: thymidine kinase, cytosine deaminase, nitroreductase, cytochrome P450, carboxypeptidase G2, purine nucleoside phosphorylase, horseradish peroxidase and carboxylesterase. 
     In some embodiments the cell comprising a CAR is specific for the oncolytic virus. In some embodiments the cell comprising a CAR is a T cell. In some embodiments the oncolytic virus is an oncolytic adenovirus (OncAd). In some embodiments the oncolytic virus is derived from adenovirus 5 (Ad5). In some embodiments the oncolytic virus encodes an E1A protein which displays reduced binding to Rb protein as compared to E1A protein encoded by Ad5. In some embodiments the oncolytic virus encodes an E1A protein lacking the amino acid sequence LTCHEACF (SEQ ID NO:105). In some embodiments the oncolytic virus encodes an E1A protein comprising, or consisting of, the amino acid sequence SEQ ID NO:104. 
     In some embodiments the oncolytic virus comprises nucleic acid having one or more binding sites for one or more transcription factors. In some embodiments the oncolytic virus comprises nucleic acid having one or more binding sites for STAT1. 
     In some embodiments the method of treating a cancer comprises:
         (a) isolating at least one cell from a subject;   (b) modifying the at least one cell to express or comprise a CAR specific for a cancer cell antigen, or a nucleic acid encoding a CAR specific for a cancer cell antigen,   (c) optionally expanding the modified at least one cell, and;   (d) administering the modified at least one cell to a subject.       

     In some embodiments the method of treating a cancer comprises:
         (a) isolating immune cells from a subject;   (b) generating or expanding a population of immune cells specific for an oncolytic virus by a method comprising: stimulating the immune cells by culture in the presence of antigen presenting cells (APCs) presenting a peptide of the oncolytic virus, and;   (c) administering at least one immune cell specific for the oncolytic virus to a subject.       

     In some embodiments the cancer is selected from head and neck cancer, head and neck squamous cell carcinoma (HNSCC), nasopharyngeal carcinoma (NPC), oropharyngeal carcinoma (OPC), prostate carcinoma, pancreatic carcinoma, cervical carcinoma (CC), gastric carcinoma (GC), hepatocellular carcinoma (HCC) and lung cancer. 
     Also provided is a helper-dependent adenovirus (HDAd) comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen. 
     Also provided is a combination, comprising:
         (i) a helper-dependent adenovirus (HDAd) comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen; and   (ii) an oncolytic virus, and/or (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen.       

     In some embodiments the antigen-binding molecule comprises (a) a single-chain variable fragment (scFv) specific for an immune cell surface molecule associated via a linker to (b) a scFv specific for a cancer cell antigen. In some embodiments the immune cell surface molecule is a CD3-TCR complex polypeptide. In some embodiments the cancer cell antigen is selected from CD44v6, CD19, HER2, PSCA, p53, CEA, GP100, EGFR, hTERT, NY-ESO1, MAGE-A3, mesothelin and MUC-1. In some embodiments the HdAd additionally comprises nucleic acid encoding an immunomodulatory factor which is an agonist of an effector immune response or an antagonist of an immunoregulatory response. In some embodiments the HdAd additionally comprises nucleic acid encoding IL-12 and/or an antagonist anti-PD-L1 antibody. In some embodiments the HdAd additionally comprises nucleic acid encoding an enzyme capable of catalysing conversion of a non-toxic factor to a cytotoxic form. In some embodiments the enzyme is selected from: thymidine kinase, cytosine deaminase, nitroreductase, cytochrome P450, carboxypeptidase G2, purine nucleoside phosphorylase, horseradish peroxidase and carboxylesterase. 
     Also provided is an antigen-binding molecule, optionally isolated or man-made, comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen. In some embodiments the antigen-binding molecule comprises (a) a heavy chain variable region (VH) and a light chain variable region (VL) specific for an immune cell surface molecule associated via a linker sequence to (b) VH and a VL specific for a cancer cell antigen. In some embodiments the immune cell surface molecule is a CD3-TCR complex polypeptide. In some embodiments the cancer cell antigen is selected from CD44v6, HER2, CD19, PSCA, p53, CEA, GP100, EGFR, hTERT, NY-ESO1, MAGE-A3, mesothelin and MUC-1. 
     Also provided is a nucleic acid, or a plurality of nucleic acids, optionally isolated or man-made, encoding the helper-dependent adenovirus (HDAd), the components of the combination, or the antigen-binding molecule according to the present disclosure. 
     Also provided is a nucleic acid, or a plurality of nucleic acids, optionally isolated or man-made, encoding: (i) an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, (ii) IL-12, and/or an antagonist anti-PD-L1 antibody. 
     Also provided is a cell comprising the helper-dependent adenovirus (HDAd), the components of the combination, the antigen-binding molecule, or the nucleic acid or plurality of nucleic acids according to the present disclosure. 
     Also provided is a pharmaceutical composition comprising the helper-dependent adenovirus (HDAd), the components of the combination, the antigen-binding molecule, the nucleic acid or plurality of nucleic acids, or the cell according to the present disclosure and a pharmaceutically acceptable carrier, diluent, excipient or adjuvant. 
     Also provided is a method of treating cancer comprising administering to a subject the helper-dependent adenovirus (HDAd), the combination, the antigen-binding molecule, the nucleic acid or plurality of nucleic acids, the cell, or the pharmaceutical composition according to the present disclosure. 
     Also provided is the helper-dependent adenovirus (HDAd), the combination, the antigen-binding molecule, the nucleic acid or plurality of nucleic acids, the cell, or the pharmaceutical composition according to the present disclosure, for use in a method of treating a cancer. 
     Also provided is the use of the helper-dependent adenovirus (HDAd), the combination, the antigen-binding molecule, the nucleic acid or plurality of nucleic acids, the cell, or the pharmaceutical composition according to the present disclosure, in the manufacture of a medicament for treating a cancer. 
     In some embodiments in accordance with various aspects of the present disclosure the cancer is selected from head and neck cancer, head and neck squamous cell carcinoma (HNSCC), nasopharyngeal carcinoma (NPC), prostate carcinoma, pancreatic carcinoma, cervical carcinoma (CC), oropharyngeal carcinoma (OPC), gastric carcinoma (GC), hepatocellular carcinoma (HCC) and lung cancer. 
     Also provided is a kit of parts comprising a predetermined quantity of the helper-dependent adenovirus (HDAd), the components of the combination, the antigen-binding molecule, the nucleic acid or plurality of nucleic acids, the cell, or the pharmaceutical composition according to the present disclosure. 
     DETAILED DESCRIPTION 
     The present disclosure is concerned with the combined use of multiple therapeutic agents for the treatment of cancer. The therapeutic agents are combined to provide an improved treatment effect as compared to the effect seen when any one of the agents is used alone. In certain embodiments, the agents act in an additive or synergistic manner to treat the cancer. 
     Antigen-Binding Molecule 
     Aspects of the present disclosure employ an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, or nucleic acid encoding said antigen-binding molecule. In some aspects, the present disclosure employs a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen. 
     An “antigen-binding molecule” refers to a molecule which is capable of binding to a target antigen, and encompasses antibodies and antibody fragments (e.g. Fv, scFv, Fab, scFab, F(ab′) 2 , Fab 2 , diabodies, triabodies, scFv-Fc, minibodies, single domain antibodies (e.g. VhH), etc.), as long as they display binding to the relevant target molecule(s). 
     The antigen-binding molecule of the present disclosure comprises antigen-binding moieties specific for particular target antigen(s). In some embodiments, an antigen-binding moiety comprises an antibody heavy chain variable region (VH) and an antibody light chain variable region (VL) of an antibody capable of specific binding to the target antigen. In some embodiments, the antigen-binding moiety comprises or consists of an aptamer capable of binding to the target antigen, e.g. a nucleic acid aptamer (reviewed, for example, in Zhou and Rossi Nat Rev Drug Discov. 2017 16(3):181-202). In some embodiments, the antigen-binding moiety comprises or consists of a antigen-binding peptide/polypeptide, e.g. a peptide aptamer, thioredoxin, monobody, anticalin, Kunitz domain, avimer, knottin, fynomer, atrimer, DARPin, affibody, nanobody (i.e. a single-domain antibody (sdAb)) affilin, armadillo repeat protein (ArmRP), OBody or fibronectin—reviewed e.g. in Reverdatto et al., Curr Top Med Chem. 2015; 15(12): 1082-1101, which is hereby incorporated by reference in its entirety (see also e.g. Boersma et al., J Biol Chem (2011) 286:41273-85 and Emanuel et al., Mabs (2011) 3:38-48). 
     An antigen-binding molecule may be, or may comprise, an antigen-binding polypeptide, or an antigen-binding polypeptide complex. An antigen-binding molecule may comprise more than one polypeptide which together form the antigen-binding molecule. The polypeptides may associate covalently or non-covalently. In some embodiments the polypeptides form part of a larger polypeptide comprising the polypeptides (e.g. in the case of scFv comprising VH and VL, or in the case of scFab comprising VH-CH1 and VL-CL). 
     The antigen-binding moieties of the present disclosure may be designed and prepared using the sequences of monoclonal antibodies (mAbs) capable of binding to the relevant target antigens. Antigen-binding regions of antibodies, such as single chain variable fragment (scFv), Fab and F(ab′)2 fragments may also be used/provided. An “antigen-binding region” is any fragment of an antibody which is capable of binding to the target for which the given antibody is specific. An antigen-binding moiety according to the present disclosure may comprise or consist of the antigen-binding region of an antibody specific for a given target. 
     Antibodies generally comprise six complementarity-determining regions CDRs; three in the heavy chain variable (VH) region: HC-CDR1, HC-CDR2 and HC-CDR3, and three in the light chain variable (VL) region: LC-CDR1, LC-CDR2, and LC-CDR3. The six CDRs together define the paratope of the antibody, which is the part of the antibody which binds to the target antigen. 
     The VH region and VL region comprise framework regions (FRs) either side of each CDR, which provide a scaffold for the CDRs. From N-terminus to C-terminus, VH regions comprise the following structure: N term-[HC-FR1]-[HC-CDR1HHC-FR2HHC-CDR2HHC-FR3HHC-CDR3HHC-FR4]-C term; and VL regions comprise the following structure: N term-[LC-FR1]-[LC-CDR1]-[LC-FR2]-[LC-CDR2]-[LC-FR3]-[LC-CDR3]-[LC-FR4]-C term. 
     There are several different conventions for defining antibody CDRs and FRs, such as those described in Kabat et al., Sequences of Proteins of Immunological Interest, 5th Ed. Public Health Service, National Institutes of Health, Bethesda, Md. (1991), Chothia et al., J. Mol. Biol. 196:901-917 (1987), and VBASE2, as described in Retter et al., Nucl. Acids Res. (2005) 33 (suppl 1): D671-D674. The CDRs and FRs of the VH regions and VL regions of the antibody clones described herein were defined according to the international IMGT (ImMunoGeneTics) information system (LeFranc et al., Nucleic Acids Res. (2015) 43 (Database issue):D413-22), which uses the IMGT V-DOMAIN numbering rules as described in Lefranc et al., Dev. Comp. Immunol. (2003) 27:55-77. 
     The antigen-binding moieties of the present disclosure generally comprise the VH and VL of an antibody capable of specific binding to the target antigen. An antigen-binding moiety formed by the combination of a VH and a VL may be referred to as an Fv. 
     In some embodiments the VH and VL of an Fv are provided on the same polypeptide chain, and are joined by a linker sequence. That is, in some embodiment the antigen-binding moiety comprises or consists of single chain Fv (scFv) specific capable of specific binding to the target antigen. 
     The antigen-binding molecule of the present disclosure is multispecific. That is, it displays specific binding to more than one target antigen. In some embodiments the antigen-binding molecule is bispecific. In some embodiments the antigen-binding molecule of the present disclosure comprises at least two, non-identical antigen-binding moieties. 
     The antigen-binding molecule of the present disclosure comprises (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen. In some embodiments the antigen-binding molecule comprises (a) an scFv specific for an immune cell surface molecule, and (b) an scFv specific for a cancer cell antigen. 
     In some embodiments the antigen-binding moieties of the antigen-binding molecule are joined by a linker sequence. 
     Linker sequences are known to the skilled person, and are described, for example in Chen et al., Adv Drug Deliv Rev (2013) 65(10): 1357-1369, which is hereby incorporated by reference in its entirety. In some embodiments, a linker sequence may be a flexible linker sequence. Flexible linker sequences allow for relative movement of the amino acid sequences which are linked by the linker sequence. Flexible linkers are known to the skilled person, and several are identified in Chen et al., Adv Drug Deliv Rev (2013) 65(10): 1357-1369. Flexible linker sequences often comprise high proportions of glycine and/or serine residues. In some embodiments, a linker sequence comprises at least one glycine residue and/or at least one serine residue. In some embodiments a linker sequence consists of glycine and serine residues. In some embodiments the linker sequence comprises, or consists, of the amino acid sequence shown in one of SEQ ID NOs:109 to 112. 
     In some embodiments, the antigen-binding moiety specific for an immune cell surface molecule comprises the CDRs of an antigen-binding molecule which is capable of binding to the immune cell surface molecule. In some embodiments the antigen-binding moiety specific for an immune cell surface molecule comprises the VH region and the VL region of an antigen-binding molecule which is capable of binding to the immune cell surface molecule. In some embodiments the antigen-binding moiety specific for an immune cell surface molecule comprises scFv capable of binding to the immune cell surface molecule. 
     In some embodiments, the antigen-binding moiety specific for a cancer cell antigen comprises the CDRs of an antigen-binding molecule which is capable of binding to the cancer cell antigen. In some embodiments the antigen-binding moiety specific for a cancer cell antigen comprises the VH region and the VL region of an antigen-binding molecule which is capable of binding to the cancer cell antigen. In some embodiments the antigen-binding moiety specific for a cancer cell antigen comprises scFv capable of binding to the cancer cell antigen. 
     It will be appreciated that the antigen-binding molecule is a multispecific antigen-binding molecule. Multispecific (e.g. bispecific) antigen-binding molecules may be provided in any suitable format, such as those formats described in described in Brinkmann and Kontermann MAbs (2017) 9(2): 182-212, which is hereby incorporated by reference in its entirety. 
     The antigen-binding molecule of the present disclosure may a bispecific T cell engager (BiTE). The structure and function of BiTEs is reviewed e.g. in Huhels et al., Immunol Cell Biol. (2015) 93(3): 290-296, which is hereby incorporated by reference in its entirety. Typically, a BiTE molecule comprises an scFv specific for a target antigen joined by a linker sequence to an scFv specific a CD3 polypeptide. The BiTE potentiates T cell activity directed against cells expressing the target protein. 
     In some embodiments the antigen-binding molecule comprises or consists of a tandem scFv, a diabody, a Fab 2  or a Triomab. In some embodiments the antigen-binding molecule comprises or consists of a tandem scFv. 
     Immune Cell Surface Molecules 
     An immune cell surface molecule may be any peptide/polypeptide, glycoprotein, lipoprotein, glycan, glycolipid, lipid, or fragment thereof expressed at or on the cell surface of an immune cell. In some embodiments, the part of the immune cell surface molecule which is bound by the antigen-binding molecule of the present disclosure is on the external surface of the immune cell (i.e. is extracellular). The immune cell surface molecule may be expressed at the cell surface of any immune cell. 
     In some embodiments, the immune cell may be a cell of hematopoietic origin, e.g. a neutrophil, eosinophil, basophil, dendritic cell, lymphocyte, or monocyte. The lymphocyte may be e.g. a T cell, B cell, natural killer (NK) cell, NKT cell or innate lymphoid cell (ILC), or a precursor thereof (e.g. a thymocyte or pre-B cell). 
     In some embodiments, the immune cell surface molecule is a molecule expressed at the surface of a T cell, e.g. CD8+ T cell or a CD4+ T cell. In some embodiments, the immune cell surface molecule is a molecule expressed at the surface of a cytotoxic T cell (e.g. a cytotoxic T lymphocyte (CTL)), a virus-specific T cell (VST), a T helper cell (e.g. a Th1, Th2, Th9, Th17, Th22 or Tfh cell), a regulatory T cell (Treg), a central memory cell (Tcm), or an effector memory cell (Tem). 
     In some embodiments the immune cell surface molecule is selected from: a CD3-TCR complex polypeptide, CD3ε, CD3γ, CD3δ, CD3ζ, CD3η, TCRα, TCRβ, TCRγ, TCRδ, CD4, CD8, CCR5, CCR7, CD2, CD7, a costimulatory molecule, CD27, CD28, OX40, 4-1BB, ICOS, a checkpoint inhibitor, PD-1, CTLA-4, LAG-3, TIM-3, TIGIT or BTLA. 
     In some embodiments the immune cell surface molecule is a CD3-TCR complex polypeptide. In some embodiments the immune cell surface molecule is a CD3 polypeptide (e.g. CD3ε, CD3γ, CD3δ, CD3ζ or CD3η). In some embodiments the immune cell surface molecule is CD3ε. 
     In some embodiments, an antigen-binding moiety specific for an immune cell surface molecule according to the present disclosure comprises: 
     a VL domain comprising:
         LC-CRD1: SEQ ID NO:75;   LC-CRD2: SEQ ID NO:76;   LC-CRD3: SEQ ID NO:77;
 
and a VH domain comprising:
   HC-CRD1: SEQ ID NO:78;   HC-CRD2: SEQ ID NO:79;   HC-CRD3: SEQ ID NO:80.       

     In some embodiments an antigen-binding moiety specific for an immune cell surface molecule comprises a VL comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:81, and a VH comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:82. 
     Cancer Cell Antigens 
     The antigen-binding molecule of the present disclosure comprises an antigen-binding moiety specific for a cancer cell antigen. Also, the chimeric antigen receptor (CAR) of the present disclosure is specific for a cancer cell antigen. 
     As used herein, a “cancer cell antigen” is an antigen which is expressed or over-expressed by a cancer cell. A cancer cell antigen may be any peptide/polypeptide, glycoprotein, lipoprotein, glycan, glycolipid, lipid, or fragment thereof. A cancer cell antigen&#39;s expression may be associated with a cancer. A cancer cell antigen may be abnormally expressed by a cancer cell (e.g. the cancer cell antigen may be expressed with abnormal localisation), or may be expressed with an abnormal structure by a cancer cell. A cancer cell antigen may be capable of eliciting an immune response. 
     In some embodiments, the antigen is expressed at the cell surface of the cancer cell (i.e. the cancer cell antigen is a cancer cell surface antigen). In some embodiments, the part of the cancer cell antigen which is bound by an antigen-binding moiety specific for a cancel cell antigen according to the present disclosure is displayed on the external surface of the cancer cell (i.e. is extracellular). In some embodiments, the antigen is anchored to the cell membrane, e.g. via a transmembrane domain or other membrane anchor (e.g. a lipid anchor such as a GPI anchor). In some embodiments, the cancer cell antigen is expressed at the cell surface (i.e. is expressed in or at the cell membrane) of a cancerous cell, but may be expressed inside the cell (i.e. is expressed inside comparable non-cancerous cells). 
     The cancer cell antigen may be a cancer-associated antigen. In some embodiments the cancer cell antigen is an antigen whose expression is associated with the development, progression and/or severity of symptoms of a cancer. The cancer-associated antigen may be associated with the cause or pathology of the cancer, or may be expressed abnormally as a consequence of the cancer. In some embodiments, the antigen is an antigen whose expression is upregulated (e.g. at the RNA and/or protein level) by cells of a cancer, e.g. as compared to the level of expression of by comparable non-cancerous cells (e.g. non-cancerous cells derived from the same tissue/cell type). 
     In some embodiments, the cancer-associated antigen may be preferentially expressed by cancerous cells, and not expressed by comparable non-cancerous cells (e.g. non-cancerous cells derived from the same tissue/cell type). In some embodiments, the cancer-associated antigen may be the product of a mutated oncogene or mutated tumor suppressor gene. In some embodiments, the cancer-associated antigen may be the product of an overexpressed cellular protein, a cancer antigen produced by an oncogenic virus, an oncofetal antigen, or a cell surface glycolipid or glycoprotein. 
     Cancer cell antigens are reviewed by Zarour H M, DeLeo A, Finn O J, et al. Categories of Tumor Antigens. In: Kufe D W, Pollock R E, Weichselbaum R R, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003. Cancer cell antigens include oncofetal antigens: CEA, Immature laminin receptor, TAG-72; oncoviral antigens such as HPV E6 and E7; overexpressed proteins: BING-4, calcium-activated chloride channel 2, cyclin-B1, 9D7, Ep-CAM, EphA3, HER2/neu, telomerase, mesothelin, SAP-1, survivin; cancer-testis antigens: BAGE, CAGE, GAGE, MAGE, SAGE, XAGE, CT9, CT10, NY-ESO-1, PRAME, SSX-2; lineage restricted antigens: MART1, Gp100, tyrosinase, TRP-1/2, MCI R, prostate specific antigen; mutated antigens: β-catenin, BRCA1/2, CDK4, CML66, Fibronectin, MART-2, p53, Ras, TGF-βRII; post-translationally altered antigens: MUC1, idiotypic antigens: Ig, TCR. Other cancer cell antigens include heat-shock protein 70 (HSP70), heat-shock protein 90 (HSP90), glucose-regulated protein 78 (GRP78), vimentin, nucleolin, feto-acinar pancreatic protein (FAPP), alkaline phosphatase placental-like 2 (ALPPL-2), siglec-5, stress-induced phosphoprotein 1 (STIP1), protein tyrosine kinase 7 (PTK7), and cyclophilin B. 
     In some embodiments the cancer cell antigen is HER2. Human epidermal growth factor receptor 2 (HER2; also known e.g. as ERBB2, CD340 and NEU) is the protein identified by UniProt P04626-1 (v1). In this specification “HER2” refers to HER2 from any species and includes HER2 isoforms (e.g. P04626-1, P04626-3, P04626-4, P04626-5 or P04626-6), fragments, variants (including mutants) or homologues from any species. 
     HER2 is overexpressed/amplified in a range of cancers, including breast cancer, ovarian cancer, bladder cancer, salivary gland cancer, endometrial cancer, pancreatic cancer and non-small-cell lung cancer (NSCLC)—see e.g. Scholl, et al., Annals of Oncology 2001, 12 (suppl 1): S81-S87. 
     As used herein, a “fragment”, “variant” or “homologue” of a protein may optionally be characterised as having at least 60%, preferably one of 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% amino acid sequence identity to the amino acid sequence of the reference protein (e.g. a reference isoform). In some embodiments fragments, variants, isoforms and homologues of a reference protein may be characterised by ability to perform a function performed by the reference protein. 
     In some embodiments the cancer cell antigen is CD44v6. CD44v6 refers to an isoform of CD44 obtained by alternative splicing, wherein exons 6 to 10 and 12 to 15 are missing. That is, the coding sequence for CD44v6 is comprised of exons 1 to 5, 11 and 16 to 20. In this specification “CD44v6” refers to CD44v6 from any species and includes fragments, variants (including mutants) or homologues from any species. Human CD44v6 has the amino acid sequence shown in SEQ ID NO:130. 
     CD44v6 is a cancer cell antigen which is abundantly expressed in head and neck squamous cell carcinomas (HNSCC), and several Phase I clinical trials for the use of anti-CD44v6 IgG bivatuzumab to treat head and neck cancer have been performed—see e.g. Riechelmann et al., Oral Oncol. (2008) 44(9):823-9; Tijink et al., Clin Cancer Res. (2006) 12(20 Pt 1):6064-72; Börjesson et al., Clin Cancer Res. (2003) 9(10 Pt 2):3961S-72S; and Postema et al., J Nucl Med. (2003) 44(10):1690-9. Bivatuzumab has also been investigated for the treatment of breast cancer—see e.g. Rupp et al., Anticancer Drugs (2007) 18(4):477-85. CD44v6 expression has also been shown to be associated with proliferation, invasion, adhesion, metastasis, chemo-/radioresistance, and the induction of EMT as well as the activation PI3K/Akt/mTOR and Wnt signaling pathways in prostate cancer (see Ni et al., Prostate (2014) 74(6):602-17), and CD44v6 is expressed by aggressive prostate cancer cells; positive staining for this marker is significantly higher in late stage, metastatic and higher-grade prostate cancer samples (see Peng et al., Oncotarget (2017) 8(49):86747-86768). CD44v6 has been suggested to be a useful marker for poor prognosis in pancreatic cancer (Gotoda et al., Jpn J Cancer Res. (1998) 89(10):1033-40). CD44v6 is also a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis (Todaro et al., Cell Stem Cell (2014) 14(3):342-56), and has been shown to be an important regulator of tumorigenesis, angiogenesis, and survival in gastric carcinoma (Xu et al., Oncotarget. (2017) 8:45848-45861). Also, CD44v6 expression levels are associated with epithelial ovarian cancer progression, metastasis and relapse (Shi et al. BMC Cancer (2013) 13:182). 
     T cells engineered to express a CD44v6-specific CAR have been demonstrated to mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma—see e.g. Casucci et al., Blood (2013) 122:3461-3472. 
     In some embodiments the cancer cell antigen is CD19. CD19 is the protein identified by UniProt P15391-1 (v6). In this specification “CD19” refers to CD19 from any species and includes CD19 isoforms (e.g. P15391-2), fragments, variants (including mutants) or homologues from any species. 
     CD19 is a marker of B cells, and is a useful target for the treatment of e.g. B cell lymphomas, acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL)—see e.g. Wang et al., Exp Hematol Oncol. (2012) 1:36. 
     In embodiments of the present disclosure where an antigen-binding molecule and a cell comprising a CAR are employed together, the antigen-binding molecule and CAR may be specific for the same cancer cell antigen, or may be specific for different cancer cell antigens. In some embodiments the antigen-binding molecule and CAR are specific for different cancer cell antigens. That is (i) the antigen-binding moiety specific for a cancer cell antigen of the antigen-binding molecule, and (ii) the antigen-binding moiety of the CAR, may be specific for the same or different cancer cell antigens. 
     In some embodiments of the present disclosure where an antigen-binding molecule and a cell comprising a CAR are employed together, the antigen-binding molecule is specific for CD44v6 and the CAR is specific for HER2. In some embodiments the antigen-binding molecule is specific for CD19 and the CAR is specific for HER2. In some embodiments the antigen-binding molecule is specific for HER2 and the CAR is specific for HER2. 
     In some embodiments, an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure comprises: 
     a VL domain comprising:
         LC-CRD1: SEQ ID NO:9;   LC-CRD2: SEQ ID NO:10;   LC-CRD3: SEQ ID NO:11;
 
and a VH domain comprising:
   HC-CRD1: SEQ ID NO:12;   HC-CRD2: SEQ ID NO:13;   HC-CRD3: SEQ ID NO:14.       

     In some embodiments an antigen-binding moiety specific for a cancer cell antigen comprises a VL comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:15, and a VH comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:16. 
     In some embodiments, an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure comprises: 
     a VL domain comprising:
         LC-CRD1: SEQ ID NO:17;   LC-CRD2: SEQ ID NO:18;   LC-CRD3: SEQ ID NO:19;
 
and a VH domain comprising:
   HC-CRD1: SEQ ID NO:20;   HC-CRD2: SEQ ID NO:21;   HC-CRD3: SEQ ID NO:22.       

     In some embodiments an antigen-binding moiety specific for a cancer cell antigen comprises a VL comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:23, and a VH comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:24. 
     In some embodiments, an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure comprises: 
     a VL domain comprising:
         LC-CRD1: SEQ ID NO:25;   LC-CRD2: SEQ ID NO:26;   LC-CRD3: SEQ ID NO:27;
 
and a VH domain comprising:
   HC-CRD1: SEQ ID NO:28;   HC-CRD2: SEQ ID NO:29;   HC-CRD3: SEQ ID NO:30.       

     In some embodiments an antigen-binding moiety specific for a cancer cell antigen comprises a VL comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:31 and a VH comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:32. 
     In some embodiments, an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure comprises: 
     a VL domain comprising:
         LC-CRD1: SEQ ID NO:33;   LC-CRD2: SEQ ID NO:34;   LC-CRD3: SEQ ID NO:35;
 
and a VH domain comprising:
   HC-CRD1: SEQ ID NO:36;   HC-CRD2: SEQ ID NO:37;   HC-CRD3: SEQ ID NO:38.       

     In some embodiments an antigen-binding moiety specific for a cancer cell antigen comprises a VL comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:39, and a VH comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:40. 
     In some embodiments, an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure comprises: 
     a VL domain comprising:
         LC-CRD1: SEQ ID NO:66;   LC-CRD2: SEQ ID NO:67;   LC-CRD3: SEQ ID NO:68;
 
and a VH domain comprising:
   HC-CRD1: SEQ ID NO:69;   HC-CRD2: SEQ ID NO:70;   HC-CRD3: SEQ ID NO:71.       

     In some embodiments an antigen-binding moiety specific for a cancer cell antigen comprises a VL comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:72, and a VH comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:73. 
     In some embodiments, an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure comprises: 
     a VL domain comprising:
         LC-CRD1: SEQ ID NO:85;   LC-CRD2: SEQ ID NO:86;   LC-CRD3: SEQ ID NO:87;
 
and a VH domain comprising:
   HC-CRD1: SEQ ID NO:88;   HC-CRD2: SEQ ID NO:89;   HC-CRD3: SEQ ID NO:90.       

     In some embodiments an antigen-binding moiety specific for a cancer cell antigen comprises a VL comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:91, and a VH comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:92. 
     In some embodiments, an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure comprises: 
     a VL domain comprising:
         LC-CRD1: SEQ ID NO:95;   LC-CRD2: SEQ ID NO:96;   LC-CRD3: SEQ ID NO:97;
 
and a VH domain comprising:
   HC-CRD1: SEQ ID NO:98;   HC-CRD2: SEQ ID NO:99;   HC-CRD3: SEQ ID NO:100.       

     In some embodiments an antigen-binding moiety specific for a cancer cell antigen comprises a VL comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:101, and a VH comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:102. 
     Nucleic Acid Encoding the Antigen-Binding Molecule 
     Aspects of the present disclosure employ nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen. 
     In some aspects, the nucleic acid is comprised within a virus. That is, the virus comprises nucleic acid encoding the antigen-binding molecule. In such embodiments, the virus acts as a vector for delivering the antigen-binding molecule. 
     Any virus capable of introducing nucleic acid into a cell (e.g. a primary human immune cell) may be used. Suitable viruses include gammaretrovirus (e.g. murine Leukemia virus (MLV)-derived vectors), lentivirus, adenovirus, adeno-associated virus, vaccinia virus and herpesvirus, e.g. as described in Maus et al., Annu Rev Immunol (2014) 32:189-225 or Morgan and Boyerinas, Biomedicines 2016 4, 9, which are both hereby incorporated by reference in its entirety. In some embodiments, the virus comprising nucleic acid encoding an immunomodulatory factor is, or is derived from, an adenovirus, lentivirus, retrovirus, or herpesvirus. 
     In some embodiments, the virus comprises nucleic acid encoding an antigen-binding molecule described hereinabove. In some embodiments, the virus further comprises nucleic acid encoding one or more immunomodulatory factors described hereinbelow. 
     In some embodiments, the virus further comprises nucleic acid encoding a further antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen. That is, in some embodiments the virus comprises nucleic acid encoding more than one antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen. In some embodiments the virus comprises nucleic acid encoding, e.g. 2, 3, 4 or 5 such antigen-binding molecules. 
     In some embodiments the encoded antigen-binding molecules are non-identical. In embodiments wherein the virus comprises nucleic acid encoding more than one antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, the antigen-binding moieties specific for a cancer cell antigen may are non-identical. For example, in some embodiments the virus encodes an antigen-binding molecule comprising an antigen-binding moiety specific for CD44v6, and an antigen-binding molecule comprising an antigen-binding moiety specific for HER2. 
     In some embodiments the virus comprises nucleic acid encoding further functional sequence(s). For example, the virus may comprise nucleic acid encoding a protein(s) for reducing growth/proliferation/survival of infected cells, or protein(s) for rendering infected cells sensitive to treatment with a given agent, or protein(s) for disrupting tumour structure (e.g. enzymes for digesting tumour matrix) to facilitate immune cell infiltration. 
     In some embodiments the virus comprises nucleic acid encoding an enzyme capable of catalysing conversion of a non-toxic factor to a cytotoxic form. The enzyme may catalyse conversion of a non-toxic prodrug into its active, cytotoxic form. 
     Enzyme/prodrug systems are well known in the art and include those described in Malekshah et al. Curr Pharmacol Rep. (2016) 2(6): 299-308 which is hereby incorporated by reference in its entirety. Examples of non-toxic prodrugs, their active cytotoxic forms and enzymes capable of catalysing conversion of the non-toxic prodrugs to their active cytotoxic forms are shown in FIG. 2 of Malekshah et al. 
     In some embodiments the virus comprises nucleic acid encoding a thymidine kinase, cytosine deaminase, nitroreductase, cytochrome P450, carboxypeptidase G2, purine nucleoside phosphorylase, horseradish peroxidase and/or carboxylesterase. In some embodiments the virus comprises nucleic acid encoding an amino acid sequence which comprises, or consists of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:42. 
     For example, the virus may comprise nucleic acid encoding thymidine kinase for rendering cells expressing the virus sensitive to treatment with ganciclovir (GCV), aciclovir (ACV) and/or valaciclovir. The virus may comprise nucleic acid encoding cytosine deaminase for rendering cells expressing the virus sensitive to treatment with 5-fluorocytosine (5-FC), which is converted by cytosine deaminase to 5-fluorouracil (5-FU). The virus may comprise nucleic acid encoding nitroreductase for rendering cells expressing the virus sensitive to treatment with CB1954, nitro-CBI-DEI and/or PR-104A. The virus may comprise nucleic acid encoding cytochrome P450 for rendering cells expressing the virus sensitive to treatment with oxazaphosphorine (e.g. cyclophosphamide or ifosfamide). The virus may comprise nucleic acid encoding carboxypeptidase G2 for rendering cells expressing the virus sensitive to treatment with nitrogen mustard based drugs (e.g. CMDA or ZD2767P). The virus may comprise nucleic acid encoding purine nucleoside phosphorylase for rendering cells expressing the virus sensitive to treatment with 6-methylpurine 2-deoxyriboside and/or fludarabine (e.g. 6-methylpurine-2′-deoxyriboside (MeP-dR), 2-F-2′-deoxyadenosine (F-dAdo) or arabinofuranosyl-2-F-adenine monophosphate (F-araAMP). The virus may comprise nucleic acid encoding horseradish peroxidase for rendering cells expressing the virus sensitive to treatment with indole-3-acetic acid (IAA). The virus may comprise nucleic acid encoding carboxylesterase for rendering cells expressing the virus sensitive to treatment with irinotecan. 
     In some embodiments the virus may comprise nucleic acid encoding antagonist of a growth factor. 
     In some embodiments, the virus may be a helper-dependent adenovirus (HDAd). HDAds are reviewed, for example, in Rosewell et al., J Genet Syndr Gene Ther (2011) Suppl 5:001, which is hereby incorporated by reference in its entirety. 
     HDAds are devoid of viral protein coding sequences, and therefore possess a large capacity (up to 37 Kb) for transduction of a coding sequence of interest. HDAds are non-integrating, and are able to efficiently transduce a wide variety of cell types independently of the cell cycle, and mediate long-term transgene expression without chronic toxicity. 
     HDAds comprise only the cis acting viral elements required for genomic replication (inverted terminal repeats (ITRs)) and encapsidation (ψ), and are therefore dependent on helper virus for propagation. When a cell is infected with both the helper virus and the HDAd, the helper virus replication machinery acts in trans to replicate and package HDAd. 
     In particular embodiments of the present disclosure, the oncolytic virus is an OncAd and the virus comprising nucleic acid encoding an immunomodulatory factor is a HDAd, and the OncAd and HDAd are able to co-infect and replicate in cells of a cancer. 
     Dependence of the HDAd on help from the OncAd provides highly localised expression of the immunomodulatory factor(s). That is, because the HDAd is only able to propagate in cells co-infected with the OncAd, and in turn because the OncAd is selective for replication in cancerous cells, expression of the factor(s) encoded by the HDAd is restricted to cancerous cells/tissue, minimising side effects. 
     Furthermore, because OncAd and HDAd efficiently target and infect tumour cells, expression of immunomodulatory factor(s) in those cells can change the normally immunosuppressive tumour microenvironment to provide conditions promoting the activation, recruitment (i.e. tumour penetration/infiltration), proliferation, activity and/or survival of effector immune cells. 
     In particular, in the context of the present disclosure wherein the CAR-T cells, expression of immunomodulatory factor(s) encoded by the virus (e.g. HDAd) provide for enhanced activation, recruitment, proliferation, activity and/or survival of the CAR-T cells. 
     In embodiments wherein the virus encodes more than one antigen-binding molecule as described herein, and/or one more immunomodulatory factors, the coding sequences may be provided in the same or different expression cassettes. That is, expression of the coding sequences may be under the control of the same regulatory sequences or different regulatory sequences. 
     In some embodiments the wherein the virus encodes more than one antigen-binding molecule as described herein, and/or one more immunomodulatory factors, the antigen-binding molecule(s)/factors may be expressed as a fusion protein. 
     In some embodiments, the virus encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen or the present disclosure comprises, or consists of, or consists essentially of, a nucleic acid sequence having at least 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:121, 122, 123, 124 or 125, or an equivalent sequence as a result of codon degeneracy. 
     Immunomodulatory Factors 
     In some embodiments, a virus encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure additionally encodes an immunomodulatory factor. In some embodiments, a virus comprises nucleic acid encoding one or more immunomodulatory factor(s). 
     Immunomodulatory factor(s) according to the present disclosure are preferably selected to facilitate the immune response to a cancer in a subject, in particular the cell-mediated immune response. In some embodiments, the immunomodulatory factor(s) provide favourable conditions for the activation, recruitment, proliferation, activity and/or survival of effector immune cells (e.g. CTLs, T H 1 cells, NK cells or NKT cells). 
     In some embodiments, the immunomodulatory factor may be an agonist of an effector immune response. An agonist of an effector immune response may be, e.g. a cytokine or chemokine promoting activation, recruitment, proliferation, activity and/or survival of effector immune cells (e.g. IL-2, IL-7, IL-17, IL-12, IL-21, IL-15, MIP-1α or RANTES), agonist antibody for a costimulatory receptor (e.g. 4-1 BB, OX40, CD28, CD27, ICOS, CD30 or GITR), or ligand for a costimulatory receptor (e.g. 4-1 BBL, OX40L, CD80, CD86, CD70, ICOSL, CD30L or GITRL). In some embodiments, the agonist of an effector immune response may be an antagonist of an immune checkpoint inhibitor, or an antagonist of ligand for immune checkpoint inhibitor, e.g. antagonist antibody to PD-L1, PD-L2, PD-1, CTLA-4, LAG-3, TIM-3, Gal-9, TIGIT, VISTA or BTLA, or an antagonist of a cytokine/chemokine which is an antagonist of an effector immune response, e.g. TGFβ (i.e. antagonist anti-TGFβ antibody or soluble/decoy TGFβ receptor). In some embodiments, an agonist of an effector immune response may be a molecule for engaging and co-opting bystander effector immune cells such as T cells and NK cells. 
     In some embodiments, the immunomodulatory factor may be an antagonist of an immunoregulatory response, e.g. an antagonist of a cytokine/chemokine promoting activation, recruitment, proliferation, activity and/or survival of immunoregulatory cells such as regulatory T cells (Tregs) and/or myeloid-derived suppressor cells (MDSCs), e.g. CCL9, CXCL10, CCL20, CCL22. 
     In some embodiments the immunomodulatory factor is IL-12. In some embodiments the immunomodulatory factor comprises, or consists of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:41. 
     In some embodiments the immunomodulatory factor is an antagonist of PD-1/PD-L1 signalling. In some embodiments the antagonist of PD-1/PD-L1 signalling is an anti-PD-L1 antibody. 
     In some embodiments the anti-PD-L1 antibody comprises an antigen-binding moiety comprising: 
     a VL domain comprising:
         LC-CRD1: SEQ ID NO:53;   LC-CRD2: SEQ ID NO:54;   LC-CRD3: SEQ ID NO:55;
 
and a VH domain comprising:
   HC-CRD1: SEQ ID NO:56;   HC-CRD2: SEQ ID NO:57;   HC-CRD3: SEQ ID NO:58.       

     In some embodiments the anti-PD-L1 antibody comprises an antigen-binding moiety comprising a VL comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:59, and a VH comprising, or consisting of, an amino acid sequence having at least 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:60. 
     Oncolytic Virus 
     Aspects of the present disclosure employ oncolytic virus. Oncolytic viruses and their use to treat cancer is reviewed, for example, in Chiocca and Rabkin Cancer Immunol Res (2014) 2(4): 295-300, which is hereby incorporated by reference in its entirety. 
     Oncolytic viruses replicate in, and cause lysis of, cancer cells. Often they are selective for cancer cells over non-cancerous cells; for example, oncolytic viruses commonly replicate in dividing cells in preference to non-dividing cells. Oncolytic viruses are therefore useful to selectively kill cancer cells and destroy tumours, without causing substantial damage to normal, non-cancerous cells/tissue. 
     Oncolytic virotherapy is associated with several advantages features. Oncolytic viruses often target several oncogenic pathways and use multiple mechanisms for cytotoxicity, minimising the chances of resistance arising. As noted above, because oncolytic viruses replicate selectively in tumours and are non-pathogenic they display minimal toxicity. Virus dose in the tumour also increases over time due to replication of the virus, and the oncolytic viruses can also be manipulated genetically to improve safety, e.g. by engineering sensitivity to a drug. 
     There are two main classes of oncolytic virus:
         (i) viruses that naturally replicate preferentially in cancer cells, and which are non-pathogenic in humans often due to elevated sensitivity to innate antiviral signalling or dependence on oncogenic signalling pathways, including autonomous parvoviruses, myxoma virus (MYXV; poxvirus), Newcastle disease virus (NDV; paramyxovirus), reovirus, and Seneca valley virus (SVV; picornavirus); and   (ii) viruses that are genetically-manipulated, e.g. with mutations/deletions in genes required for replication in normal, but not cancer cells, including adenovirus (Ad), herpes simplex virus (HSV), vaccinia virus (VV), and vesicular stomatitis virus (VSV; rhabdovirus); or viruses that are genetically-manipulated for use as vaccine vectors including measles virus (MV; paramyxovirus), poliovirus (PV; picornavirus), and VV (poxvirus).       

     Genetic manipulation can include insertion/alteration of functional sequences to provide enhanced selectivity for cancer cells, safety, and/or to modify virus tropism. 
     For example, oncolytic virus may by genetically engineered to introduce tissue-specific internal ribosome entry sites (IRESs) only permitting viral translation in target cells, and/or to introduce miRNAs/miRNA response elements (MREs); differential miRNA expression between healthy cells or certain tissues vs. tumor cells allows viruses to be detargeted from healthy cells/tissues. Oncolytic virus may also by engineered to place transcription of the viral genome under the control of a cell- or tissue-specific regulatory region, such as promoter/enhancers (e.g. tumour cell-specific promoter). In some embodiments, the oncolytic virus according to the present disclosure may comprise one or more modifications for such purpose. 
     Virus may also be modified for transductional targeting, e.g. through modification of virus receptors/coat proteins to target tumour cells and/or detarget healthy cells/tissues. 
     Oncolytic viruses may be administered in such a way as to minimise anti-oncolytic virus responses (e.g. neutralisation by anti-virus antibodies) in the subject and sequestration in the liver, and to maximise tumour delivery, as described in Chiocca and Rabkin, supra. For example, oncolytic virus may be administered in a cell carrier, e.g. in mesenchymal stromal cells, myeloid-derived suppresser cells (MDSCs), neural stem cells, T cells, cytokine-induced killer cells, or irradiated tumor cells, or can be coated in nanoparticles. 
     In some embodiments, the oncolytic virus of the present disclosure is, or is derived from, an adenovirus (Ad), herpes simplex virus (HSV), vaccinia virus (VV), vesicular stomatitis virus (VSV); autonomous parvovirus, myxoma virus (MYXV), Newcastle disease virus (NDV), reovirus, Seneca valley virus (SVV) morbillivirus virus, retrovirus, influenza virus, Sindbis virus (SINV) or poxvirus, as examples. In some embodiments, the oncolytic virus is not vaccinia virus. In some embodiments, the oncolytic virus is not vaccinia virus JX-594. 
     As used herein, an oncolytic virus which is “derived from” a reference virus comprises a nucleic acid sequence or amino acid sequence which is possessed by the reference virus. In some embodiments an oncolytic virus which is “derived from” a reference virus comprises one or more genes possessed by the reference virus. In some embodiments an oncolytic virus which is “derived from” encodes one or more proteins encoded by the reference virus. 
     In some embodiments, an oncolytic virus which is derived from a reference virus may comprise nucleic acid sequence encoding one or more functional elements of the reference virus. A “functional element” may e.g. be a transcriptional regulator (e.g. a promoter/enhancer), a regulator of post-transcriptional processing, a translational regulator, a regulator of post-transcriptional processing, a response element, a repeat sequence, or a viral protein. In some embodiments, an oncolytic virus which is derived from a reference virus may comprise one or more genes of, or proteins encoded by, the reference virus. 
     In some embodiments the oncolytic virus of the present disclosure is, or is derived from, an adenovirus (OncAd). OncAds are reviewed e.g. in Larson et al., Oncotarget. (2015) 6(24): 19976-19989, which is hereby incorporated by reference in its entirety. 
     In some embodiments the OncAd is, or is derived from, a species A, B, C, D, E, F or G human adenovirus (i.e. HAdV-A, HAdV-B, HAdV-C, HAdV-D, HAdV-E, HAdV-F or HAdV-G). In some embodiments the OncAd is, or is derived from, a species C human adenovirus. In some embodiments the OncAd is, or is derived from, Ad5, Ad2, Ad1, Ad6 or Ad57. 
     In some embodiments the OncAd is a conditionally replicating adenovirus (or CRAd). 
     In some embodiments the OncAd has reduced ability to infect, replicate in and/or lyse non-cancerous cells (as compared to the ability to infect/replicate in and/or lyse equivalent cancerous cells), for example as a consequence of a genetic modification of the adenovirus from which the OncAd is derived. 
     In some embodiments the oncolytic virus comprises a modification to one or more protein encoding sequences. In some embodiments, the modification alters the production or activity of the encoded protein. In some embodiments, the modification is a truncation or deletion of the protein. 
     In some embodiments, the OncAd comprises modification to an adenovirus early protein. In some embodiments, the modification is to the region encoding E1A protein. In some embodiments, the OncAd encodes an E1A protein having reduced ability to bind to Rb protein as compared to wildtype E1A protein (e.g. E1A encoded by the adenovirus from which the OncAd is derived). In some embodiments the OncAd encodes an E1A protein lacking the amino acid sequence LTCHEACF (SEQ ID NO:105). An example of an OncAd comprising encodes an E1A protein lacking the amino acid sequence LTCHEACF (SEQ ID NO:105) is Onc5/3Ad2E1Δ24 shown in SEQ ID NO:104. 
     In some embodiments the oncolytic virus encodes an E1A protein comprising, or consisting of or consisting essentially of, an amino acid sequence having at least 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:104. 
     In some embodiments the oncolytic virus according to the present disclosure comprises, or consists of, or consists essentially of, a nucleic acid sequence having at least 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:126 or an equivalent sequence as a result of codon degeneracy. 
     In some embodiments, the oncolytic virus comprises a nucleic acid sequence providing one or more binding sites for one or more transcription factors. In some embodiments, the transcription factor is an activating transcription factor (i.e. a transcriptional activator). The one or more binding sites for one or more transcription factors are preferably provided upstream of (i.e. 5′ to) to nucleic acid sequence encoding one or more functional elements (e.g. viral proteins). 
     In some embodiments, the transcription factor is a transcription factor having increased expression, or increased activity, in cancerous cells as compared to comparable non-cancerous cells (e.g. non-cancerous cells derived from the same tissue/cell type). 
     Herein, “expression” may refer to gene expression or protein expression. Gene expression can be measured by various means known to those skilled in the art, for example by measuring levels of mRNA by quantitative real-time PCR (qRT-PCR), or by reporter-based methods. Similarly, protein expression can be measured by various methods well known in the art, e.g. by antibody-based methods, for example by western blot, immunohistochemistry, immunocytochemistry, flow cytometry, ELISA, ELISPOT, or reporter-based methods. 
     An example of an OncAd comprising one or more binding sites for one or more transcription factors is ICOVIR15 described in Rojas et al. 2010 Mol Ther 18 1960-1971, which is hereby incorporated by reference its entirety. ICOVIR15 comprises 8 binding sites for the transcription factor E2F. 
     In some embodiments the oncolytic virus comprises one or more binding sites for a transcription factor whose gene or protein expression, or activity in a cell, is upregulated in response to a factor produced or expressed by an immune cell. In some embodiments, a factor produced or expressed by an immune cell may at least one cytokine/chemokine produced by, or a protein expressed at the cell surface of, an effector immune cell, e.g. CD8+ cytotoxic T lymphocyte (CTL), CD4+T helper 1 (T H 1) cell, natural killer (NK) cell or natural killer T (NKT) cell. 
     In some embodiments, the oncolytic virus of the present disclosure comprises one or more binding sites for a STAT transcription factor. In some embodiments, the oncolytic virus comprises one or more binding sites for a STAT1. An ICOSTAT OncAd described herein possesses 8 binding sites for STAT1, and STAT1 is known to be upregulated by IFNγ. In particular embodiments, ICOSTAT is a particularly effective treatment for a cancer because the host&#39;s immune response to the cancer cells will promote the replication of the oncolytic virus in situ. 
     In some embodiments, the oncolytic virus comprises more than one binding site for a STAT1, e.g. at least 2, 3, 4, 5, 6, 7, 8, 9, or 10 binding sites for STAT1. In some embodiments, a binding site for STAT1 may comprise or consist of or consist essentially of the sequence TTCCGGGAA (SEQ ID NO:128), or TTCTCGGAA (SEQ ID NO:129). In some embodiments, the oncolytic virus of the present disclosure comprises one or more copies of the sequence TTCCGGGAA (SEQ ID NO:128) or TTCTCGGAA (SEQ ID NO:129). 
     In some embodiments the oncolytic virus according to the present disclosure comprises, or consists of, or consists essentially of, a nucleic acid sequence having at least 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:127 or an equivalent sequence as a result of codon degeneracy. 
     Chimeric Antigen Receptors (CARs) and CAR-Expressing Cells 
     The present disclosure employs immune cells comprising a chimeric antigen receptor (CAR). The CAR of the present disclosure comprises an antigen-binding moiety specific for a cancer cell antigen. The cancer cell antigen may be a cancer cell antigen as described hereinabove. 
     Chimeric Antigen Receptors (CARs) are recombinant receptors that provide both antigen-binding and immune cell activating functions. CAR structure and engineering is reviewed, for example, in Dotti et al., Immunol Rev (2014) 257(1), hereby incorporated by reference in its entirety. CARs comprise an antigen-binding moiety linked to a cell membrane anchor region and a signaling region. An optional hinge region may provide separation between the antigen-binding moiety and cell membrane anchor region, and may act as a flexible linker. 
     The antigen-binding moiety of a CAR may be based on the antigen-binding moiety of an antibody which is specific for the antigen to which the CAR is targeted, or other agent capable of binding to the target. For example, the antigen-binding moiety of a CAR may comprise amino acid sequences for the complementarity-determining regions (CDRs) or complete light chain and heavy chain variable region amino acid sequences of an antibody which binds specifically to the target protein. Antigen-binding moieties of CARs may target antigen based on other protein:protein interaction, such as ligand:receptor binding; for example an IL-13Rα2-targeted CAR has been developed using an antigen-binding moiety based on IL-13 (see e.g. Kahlon et al. 2004 Cancer Res 64(24): 9160-9166). 
     In some embodiments the CAR of the present disclosure comprise an antigen-binding moiety specific for a cancer cell antigen as described herein. 
     The antigen-binding moiety of the CAR may be provided with any suitable format, e.g. scFv, Fab, etc. In some embodiments, the antigen-binding moiety of the CAR comprises or consists of a cancer cell antigen-binding scFv. 
     The cell membrane anchor region is provided between the antigen-binding moiety and the signalling region of the CAR. The cell membrane anchor region provides for anchoring the CAR to the cell membrane of a cell expressing a CAR, with the antigen-binding moiety in the extracellular space, and signalling region inside the cell. Suitable transmembrane domains include transmembrane region derived from CD28, CD3-ζ, CD4 or CD8. 
     In some embodiments the cell membrane anchor region comprises, or consists of or consists essentially of, an amino acid sequence having at least 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:5. 
     The signalling region of a CAR allows for activation of the T cell. The CAR signalling regions may comprise the amino acid sequence of the intracellular domain of CD3-, which provides immunoreceptor tyrosine-based activation motifs (ITAMs) for phosphorylation and activation of the CAR-expressing T cell. Signalling regions comprising sequences of other ITAM-containing proteins have also been employed in CARs, such as domains comprising the ITAM containing region of FcγRI (Haynes et al., 2001 J Immunol 166(1):182-187). CARs comprising a signalling region derived from the intracellular domain of CD3-ζ are often referred to as first generation CARs. 
     In some embodiments the signaling region comprises, or consists of, an amino acid sequence having at least 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:7. 
     Signalling regions of CARs may also comprise co-stimulatory sequences derived from the signalling region of co-stimulatory molecules, to facilitate activation of CAR-expressing T cells upon binding to the target protein. Suitable co-stimulatory molecules include at least CD28, OX40, 4-1BB, ICOS and CD27. CARs having a signalling region including additional co-stimulatory sequences are often referred to as second generation CARs. 
     In some cases CARs are engineered to provide for co-stimulation of different intracellular signalling pathways. For example, signalling associated with CD28 costimulation preferentially activates the phosphatidylinositol 3-kinase (P13K) pathway, whereas the 4-1 BB-mediated signalling is through TNF receptor associated factor (TRAF) adaptor proteins. Signalling regions of CARs therefore sometimes contain co-stimulatory sequences derived from signalling regions of more than one co-stimulatory molecule. CARs comprising a signalling region with multiple co-stimulatory sequences are often referred to as third generation CARs. 
     In some embodiments, the CAR of the present disclosure comprises one or more co-stimulatory sequences comprising or consisting of or consisting essentially of an amino acid sequence which comprises, consists of or consists essentially of, or is derived from, the amino acid sequence of the intracellular domain of one or more of CD28, OX40, 4-1 BB, ICOS and CD27. 
     In some embodiments the signaling region comprises, or consists of, an amino acid sequence having at least 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:6. 
     An optional hinge region may provide separation between the antigen-binding moiety and the transmembrane domain, and may act as a flexible linker. Hinge regions may be flexible domains allowing the binding moiety to orient in different directions. Hinge regions may be derived from IgG1 or the CH 2 CH 3  region of immunoglobulin. In some embodiments, the CAR of the present disclosure comprises a hinge region comprising or consisting of or consisting essentially of an amino acid sequence which comprises, consists of or consists essentially of, or is derived from, the amino acid sequence of the hinge region of IgG1 or the CH 2 CH 3  region of immunoglobulin. 
     In some embodiments the hinge region comprises, or consists of, an amino acid sequence having at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:8. 
     In some embodiments the CAR comprises, or consists of, an amino acid sequence having at least 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or having 100% sequence identity to SEQ ID NO:1, 2, 3 or 4. 
     The present disclosure also provides a cell comprising or expressing a CAR according to the present disclosure. Also provided is a cell comprising or expressing a nucleic acid encoding a CAR according to the disclosure. Engineering of CARs into T cells may be performed during culture, in vitro, for transduction and expansion, such as happens during expansion of T cells for adoptive T cell therapy. 
     Methods for engineering immune cells to express CARs are known to the skilled person and are described e.g. in Wang and Rivière Mol Ther Oncolytics. (2016) 3:16015, which is hereby incorporated by reference in its entirety. It will be appreciated that “at least one cell” encompasses plural cells, e.g. populations of such cells. 
     The cell comprising or expressing a CAR according to the present disclosure may be a eukaryotic cell, e.g. a mammalian cell. The mammal may be a human, or a non-human mammal (e.g. rabbit, guinea pig, rat, mouse or other rodent (including any animal in the order Rodentia), cat, dog, pig, sheep, goat, cattle (including cows, e.g. dairy cows, or any animal in the order Bos), horse (including any animal in the order Equidae), donkey, and non-human primate). 
     In some embodiments, the cell may be from, or may have been obtained from, a human subject. Where the CAR-expressing cell is to be used in the treatment of a subject, the cell may be from the subject to be treated with the CAR-expressing cell (i.e. the cell may be autologous), or the cell may be from a different subject (i.e. the cell may be allogeneic). 
     The cell may be an immune cell. The cell may be a cell of hematopoietic origin, e.g. a neutrophil, eosinophil, basophil, dendritic cell, lymphocyte, or monocyte. The lymphocyte may be e.g. a T cell, B cell, NK cell, NKT cell or innate lymphoid cell (ILC), or a precursor thereof. The cell may express e.g. CD3 polypeptides (e.g. CD3γ CD3ε CD3ζ or CD3δ), TCR polypeptides (TCRα or TCRβ), CD27, CD28, CD4 or CD8. 
     In some embodiments, the cell is a T cell. In some embodiments, the T cell is a CD3+ T cell. In some embodiments, the T cell is a CD3+, CD8+ T cell. In some embodiments, the T cell is a cytotoxic T cell (e.g. a cytotoxic T lymphocyte (CTL)). 
     The use of CAR T-cells is associated with advantages that they can be systemically administered, and will home to both primary and metastasized tumors (Manzo et al., Human Molecular Genetics (2015) R67-73). 
     In some embodiments, the cell is an antigen-specific T cell. In embodiments herein, an “antigen-specific” T cell is a cell which displays certain functional properties of a T cell in response to the antigen for which the T cell is specific, or a cell expressing said antigen. In some embodiments, the properties are functional properties associated with effector T cells, e.g. cytotoxic T cells. 
     In some embodiments, an antigen-specific T cell may display one or more of the following properties: cytotoxicity, e.g. to a cell comprising/expressing antigen for which the T cell is specific; proliferation, IFNγ expression, CD107a expression, IL-2 expression, TNFα expression, perforin expression, granzyme expression, granulysin expression, and/or FAS ligand (FASL) expression, e.g. in response to antigen for which the T cell is specific or a cell comprising/expressing antigen for which the T cell is specific. Antigen-specific T cells comprise a TCR capable of recognising a peptide of the antigen for which the T cell is specific when presented by the appropriate MHC molecule. Antigen-specific T cells may be CD4+ T cells and/or CD8+ T cells. 
     In some embodiments, the antigen for which the T cell is specific may be a peptide or polypeptide of a virus, e.g. Adenovirus, Cytomegalovius (CMV), Epstein-Barr virus (EBV), human papilloma virus (HPV), influenza virus, measles virus, hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), lymphocytic choriomeningitis virus (LCMV), or herpes simplex virus (HSV). 
     A T cell which is specific for an antigen of a virus may be referred to herein as a virus-specific T cell (VST). VSTs may be CD4+ T cells (e.g. T H  cells) and/or CD8+ T cells (e.g. CTLs). A T cell which is specific for an antigen of a particular virus may be described as being specific for the relevant virus; for example, a T cell which is specific for an antigen of an Adenovris may be referred to as an Adenovirus-specific T cell, or “AdVST”. The use of virus-specific T cells for the generation of CAR-T cells is associated with the advantage that whilst naïve T cells may have limited long-term persistence after infusion, virus-specific T-cells (VSTs) derived from the memory compartment, and genetically-modified VSTs have been shown to persist for over 10 years after infusion in stem cell transplant recipients (Cruz et al., Cytotherapy (2010) 12:743-749). For example, VSTs expressing GD2. CARs have been shown to persist long-term after infusion and produce complete tumor responses in patients with low tumor burden (Sun et al., Journal for Immunotherapy of Cancer (2015) 3:5 and Pule et al., Nature Medicine (2008) 14: 1264-1270). 
     In some embodiments the cell comprising/expressing the CAR is a virus-specific T cell (VST, e.g. a virus-specific CD4+ T cell (e.g. T H  cell) and/or a virus-specific CD8+ T cell (e.g. CTL). In some embodiments the CAR-expressing cell is an Adenovirus-specific T cell (AdVST), Cytomegalovius-specific T cell (CMVST), Epstein-Barr virus-specific T cell (EBVST), influenza virus-specific T cell, measles virus-specific T cell, hepatitis B virus-specific T cell (HBVST), hepatitis C virus-specific T cell (HCVST), human immunodeficiency virus-specific T cell (HIVST), lymphocytic choriomeningitis virus-specific T cell (LCMVST), Herpes simplex virus-specific T cell (HSVST) or human papilloma virus (HPVST). 
     In some embodiments the cell comprising/expressing the CAR is an oncolytic virus-specific immune cell (e.g. an oncolytic virus-specific T cell), e.g. as described herein. 
     Any cells of the disclosure may be included in an isolated population of cells that may or may not be homogeneous. In specific embodiments, the cell population has a majority of cells that are immune cells specific for an oncolytic virus and/or that express a CAR. The cells in the cell population may comprise an oncolytic adenovirus (OncAd), a helper-dependent adenovirus (HDAd), a chimeric antigen receptor (CAR) and/or nucleic acid or plurality of nucleic acids that encodes one or more of the OncAd, HDAd, and/or CAR. In particular embodiments, the cell population has at least 70, 75, 80, 85, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99% of cells that comprise an oncolytic adenovirus (OncAd), a helper-dependent adenovirus (HDAd), a chimeric antigen receptor (CAR) and/or nucleic acid or plurality of nucleic acids that encodes one or more of the OncAd, HDAd, and/or CAR. 
     Additional Sequences 
     The polypeptides of the present disclosure (i.e. the antigen-binding molecules (e.g. BiTEs), CARs, immunomodulatory factors, fusion proteins) may additionally comprise further amino acids or sequences of amino acids, e.g. to facilitate expression, folding, trafficking, processing, purification and/or detection. 
     The polypeptides of the present disclosure may additionally comprise a signal peptide (also known as a leader sequence or signal sequence). Signal peptides normally consist of a sequence of 5-30 hydrophobic amino acids, which form a single alpha helix. Secreted proteins and proteins expressed at the cell surface often comprise signal peptides. The signal peptide may be present at the N-terminus, and may be present in the newly synthesised polypeptide. Signal peptides are often removed by cleavage, and thus are not comprised in the mature polypeptide. Signal peptides are known for many proteins, and are recorded in databases such as GenBank, UniProt, Swiss-Prot, TrEMBL, Protein Information Resource, Protein Data Bank, Ensembl, and InterPro, and/or can be identified/predicted e.g. using amino acid sequence analysis tools such as SignalP (Petersen et al., 2011 Nature Methods 8: 785-786) or Signal-BLAST (Frank and Sippl, 2008 Bioinformatics 24: 2172-2176. In some embodiments a polypeptide according to the present disclosure comprises an amino acid sequence having at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:106, 107 or 108. 
     The polypeptides of the present disclosure may comprise one or more linker sequences (e.g. flexible linker sequences), e.g. as described hereinabove. In some embodiments a polypeptide according to the present disclosure comprises an amino acid sequence having at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:109, 110, 111 or 112. 
     The polypeptides of the present disclosure may comprise one or more detectable moieties. A detectable moiety may be e.g. a fluorescent, lunminescent, immuno-detectable, radio, chemical, nucleic acid or enzymatic moiety. In some embodiments the polypeptides comprise a sequence encoding a HA, His, (e.g. 6×His), Myc, GST, MBP, FLAG, E, or Biotin tag, optionally at the N- or C-terminus of the polypeptide. In some embodiments a polypeptide according to the present disclosure comprises an amino acid sequence having at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:113 or 114. 
     The polypeptide(s) of the present disclosure may comprise one or more cleavable linker sequences. That is, the polypeptide(s) may comprise sequence(s) of amino acids which are capable of being cleaved. For example, a cleavable linker sequence may comprise a sequence capable of acting as a substrate for an enzyme capable of cleaving peptide bonds—i.e. a cleavage site. Many such cleavage sites are known to and can be employed by the person skilled in the art of molecular biology. In some embodiments, a cleavable linker sequence may comprise an autocleavage site. Autocleavage sites are automatically cleaved without the need for treatment with enzymes. An example of an autocleavage site is an amino acid sequence conforming to the 2A cleavage sequence consensus shown in SEQ ID NO:116, which is cleaved at “G/P”. SEQ ID NO:115 is an example of cleavable linker sequence comprising a the 2A cleavage sequence conforming to the 2A cleavage sequence consensus shown in SEQ ID NO:116. In some embodiments a polypeptide according to the present disclosure comprises an amino acid sequence having at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:115 or 116. 
     Oncolytic Virus-Specific Immune Cells 
     Aspects of the present disclosure employ oncolytic virus-specific immune cells (also referred to herein as immune cells specific for an oncolytic virus). Oncolytic virus-specific immune cells express/comprise a receptor capable of recognising a peptide of an antigen of an oncolytic virus (e.g. when presented by an MHC molecule). The immune cell may express/comprise such a receptor as a result of expression of endogenous nucleic acid encoding such antigen receptor, or as a result of having been engineered to express such a receptor. 
     In some embodiments an oncolytic virus-specific immune cell may be a cell of hematopoietic origin, e.g. a neutrophil, eosinophil, basophil, dendritic cell, lymphocyte, or monocyte. The lymphocyte may be e.g. a T cell, B cell, NK cell, NKT cell or innate lymphoid cell (ILC), or a precursor thereof. The cell may express e.g. CD3 polypeptides (e.g. CD3γ CD3ε CD3ζ or CD3δ), TCR polypeptides (TCRα or TCRβ), CD27, CD28, CD4 or CD8. In some embodiments, the oncolytic virus-specific immune cell is a T cell, e.g. a CD3+ T cell. In some embodiments, the T cell is a CD3+, CD4+ T cell. In some embodiments, the T cell is a CD3+, CD8+ T cell. In some embodiments, the T cell is a T helper cell (T H  cell)). In some embodiments, the T cell is a cytotoxic T cell (e.g. a cytotoxic T lymphocyte (CTL)). 
     The oncolytic virus-specific immune cell (e.g. oncolytic virus-specific T cell) may be specific for an oncolytic virus as described herein. That is to say, the oncolytic virus-specific immune cell may be specific for one or more antigens of an oncolytic virus described herein. 
     Methods for generating/expanding populations of immune cells specific for antigen(s) of interest and/or a virus of interest are well known in the art, and are described e.g. in Wang and Rivière Cancer Gene Ther. (2015) 22(2):85-94, which is hereby incorporated by reference in its entirety. 
     Such methods may involve contacting heterogeneous populations of immune cells (e.g. peripheral blood mononuclear cells (PBMCs), peripheral blood lymphocytes (PBLs) tumor-infiltrating lymphocytes (TILs)) with one or more peptides of the antigen(s) of interest, or cells comprising/expressing the antigen(s)/peptides. Cells comprising/expressing the antigen(s)/peptides may do so as a consequence of infection with the virus comprising/encoding the antigen(s), uptake by the cell of the antigen(s)/peptides thereof or expression of the antigen(s)/peptides thereof. The presentation is typically in the context of an MHC molecule at the cell surface of the antigen-presenting cell. 
     Cells comprising/expressing the antigen(s)/peptides may have been contacted (“pulsed”) with peptides of the antigen(s) according to methods well known to the skilled person. Antigenic peptides may be provided in a library of peptide mixtures (corresponding to one or more antigens), which may be referred to as pepmixes. Peptides of pepmixes may e.g. be overlapping peptides of 8-20 amino acids in length, and may cover all or part of the amino acid sequence of the relevant antigen. 
     Cells within the population of immune cells comprising receptors specific for the peptide(s) may be activated (and stimulated to proliferate), following recognition of peptide(s) of the antigen(s) presented by antigen-presenting cells (APCs) in the context of appropriate costimulatory signals. It will be appreciated that “an immune cell specific for an oncolytic virus” encompasses plural cells, e.g. populations of such cells. Such populations may be generated/expanded in vitro and/or ex vivo. 
     In some embodiments, an immune cell specific for an oncolytic virus is specific for an oncolytic adenovirus (OncAd), e.g. an OncAd as described herein. In some embodiments, an immune cell specific for an oncolytic virus is specific for an antigen of an OncAd. In some embodiments, the antigen is, or is derived from, an OncAd protein, e.g. a protein encoded by an early gene (e.g. E1 (e.g. E1A, E1B), E2 (e.g. E2A, E2B), E3 or E4), a protein encoded by a late gene (e.g. L1, L2, L3, L4 or L5), a protein encoded by IX, or a protein encoded by IVa2. In some embodiments, the antigen is, or is derived from, an OncAd hexon and/or penton. 
     In some embodiments in accordance with various aspects of the present disclosure an immune cell specific for a virus may be generated/expanded (or may have been generated/expanded) by a method comprising: stimulating a population of immune cells by culture in the presence of antigen presenting cells (APCs) presenting a peptide of the virus. 
     In some embodiments an immune cell specific for an oncolytic virus according to the present disclosure is prepared by a method employing a PepMix comprising a mixture of overlappying peptides corresponding to Human Adenovirus 3 hexon and/or a PepMix comprising a mixture of overlappying peptides corresponding to Human Adenovirus 5 penton. 
     In some embodiments the oncolytic virus-specific immune cell expresses/comprises a CAR, e.g. a CAR as described herein. The oncolytic virus-specific immune cell may be engineered to express a CAR e.g. by transfection/transduction of the oncolytic virus-specific immune cell with nucleic acid encoding a CAR. 
     Combinations of the Disclosure 
     Aspects of the present invention include compositions and methods comprising/employing (i) a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen; and (ii) an oncolytic virus. Also provided are compositions and methods comprising/employing (i) a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen; and (ii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. Also provided are compositions and methods comprising/employing (i) a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen; (ii) an oncolytic virus; and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. 
     In some embodiments in accordance with various aspects described herein the cell comprising/expressing the CAR is specific for the oncolytic virus employed (e.g. comprises antigen receptor (e.g. TCR) specific for an antigen of the oncolytic virus). That is to say, in some embodiments the oncolytic virus and the specificity of the cell comprising/expressing the CAR are matched. By way of example, in some embodiments the oncolytic virus is an adenovirus, and the CAR-expressing cell comprising/expressing a CAR is an Adenovirus-specific T cell. 
     Similarly, in various aspects described herein an oncolytic virus is employed in combination with an immune cell specific for the oncolytic virus (i.e. the same oncolytic virus). 
     “Combinations” as referred to herein encompass products and compositions (e.g. pharmaceutical compositions) comprising the components of the combination. “Combinations” also encompass therapeutic regimens employing the components of the combination. 
     In some embodiments the components of a combination are provided in separate compositions. In some embodiments more than one component of a combination is provided in a composition. In some embodiments the components of a combination are provided in one composition. 
     Similarly, in some embodiments the components of a combination are administered separately. In some embodiments a component of a combination is administered with another component of the combination. In some embodiments the components of a combination are administered together. 
     By way of illustration, in the example of a combination comprising an oncolytic virus, a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, and at least one cell comprising a CAR specific for a cancer cell antigen, the oncolytic virus and the virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen may be administered together, and the at least one cell comprising a CAR specific for a cancer cell antigen may be administered separately (e.g. subsequently). 
     Where components of a combination are administered together administration may be simultaneous administration as described hereinbelow. Where components of a combination are administered separately, administration may be simultaneous administration or sequential administration, as described hereinbelow. In cases wherein components of a combination are administered separately, the administration of the separate components may or may not be administered via the same administration routes. 
     Functional Properties 
     The articles of the present disclosure (e.g. viruses (e.g. oncolytic viruses, HDAds), antigen-binding molecules (e.g. BiTEs), CARs, immunomodulatory factors (e.g. IL-12, anti-PD-L1 minibody), nucleic acids, cells, compositions and combinations) of the present disclosure may be defined by reference to one of more functional properties. The articles may be evaluated for the functional properties, for example, by analysis as described in the experimental examples. 
     In some embodiments, a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure may possess one or more of the following functional properties:
         ability to cause/increase cell killing of cancer cells;   reduced ability to cause/increase cell killing of non-cancerous cells as compared to the ability to cause/increase cell killing of cancer cells.       

     In some embodiments, an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure may possess one or more of the following functional properties:
         ability to bind to the cancer cell antigen for which the antigen-binding molecule comprise a specific antigen-binding moiety;   ability to bind to cells expressing the cancer cell antigen for which the antigen-binding molecule comprise a specific antigen-binding moiety;   ability to bind to the immune cell surface molecule for which the antigen-binding molecule comprise a specific antigen-binding moiety;   ability to bind to cells expressing the immune cell surface molecule for which the antigen-binding molecule comprise a specific antigen-binding moiety;   ability to cause/increase killing of cells expressing the cancer cell antigen for which the antigen-binding molecule comprise a specific antigen-binding moiety, e.g. by immune cells expressing the immune cell surface molecule for which the antigen-binding molecule comprise a specific antigen-binding moiety.       

     In some embodiments, an oncolytic virus according to the present disclosure may possess one or more of the following functional properties:
         ability to replicate in, and/or cause cell killing of, cancer cells;   reduced ability to replicate in and/or cause cell killing of, non-cancerous cells as compared to the ability to replicate in, and/or cause cell killing of, cancer cells;   comparable or improved ability to cause cell killing of cancer cells as compared to the ability of one or more oncolytic viruses known in the art;   ability to help replication of helper-dependent adenovirus (HDAd);   comparable or improved ability to replicate in cancer cells as compared to the ability of one or more oncolytic viruses known in the art.       

     In some embodiments, a cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen according to the present disclosure may possess one or more of the following functional properties:
         ability to bind to the cancer cell antigen for which the CAR is specific;   ability to bind to cells expressing the cancer cell antigen for which the CAR is specific;   ability to cause cell killing of cells expressing the cancer cell antigen for which the CAR is specific;   reduced ability to cause cell killing of cells not expressing the cancer cell antigen for which the CAR is specific as compared to the ability to cause cell killing of cells expressing the cancer cell antigen for which the CAR is specific.       

     In some embodiments the combination of a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen and an oncolytic virus may possess one or more of the following functional properties:
         improved ability to cause cell killing of cancer cells as compared to the ability to cause cell killing of cancer cells by either component used alone.   ability to cause cell killing of cancer cells which is synergistic (i.e. super-additive) as compared to the ability to cause cell killing of cancer cells by the components used alone.       

     In some embodiments the combination of a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen and at least one cell comprising a CAR specific for a cancer cell antigen may possess one or more of the following functional properties:
         improved ability to cause cell killing of cancer cells as compared to the ability to cause cell killing of cancer cells by either component used alone.   ability to cause cell killing of cancer cells which is synergistic (i.e. super-additive) as compared to the ability to cause cell killing of cancer cells by the components used alone.       

     In some embodiments the combination of a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, an oncolytic virus and at least one cell comprising a CAR specific for a cancer cell antigen may possess one or more of the following functional properties:
         improved ability to cause cell killing of cancer cells as compared to the ability to cause cell killing of cancer cells by any one of the components use alone, or by any two of the components used in combination.   ability to cause cell killing of cancer cells which is synergistic (i.e. super-additive) as compared to the ability to cause cell killing of cancer cells by the components used alone.       

     Analysis of the ability to cause cell killing of cancer cells may be assessed e.g. in vitro, by analysis of number/viability of cancer cells. Analysis of the ability to cause cell killing of cancer cells may also be analysed in vivo in an appropriate model, e.g. by analysis of number of cancer cells, tumor size/volume and/or some other correlate of the number of cancer cells (e.g. disease progression, severity of symptoms of the cancer etc.). 
     Articles of the Disclosure, Compositions and Kits 
     The present disclosure also provides a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, optionally isolated. Also provided is a nucleic acid encoding the virus, optionally isolated. Also provided is a cell comprising the virus, or comprising nucleic acid encoding the virus, optionally isolated. Also provided is a composition comprising the cell, nucleic acid or virus. 
     The present disclosure also provides an oncolytic virus according to the present disclosure, optionally isolated. Also provided is a nucleic acid encoding the oncolytic virus, optionally isolated. Also provided is a cell comprising the oncolytic virus, or comprising nucleic acid encoding the oncolytic virus, optionally isolated. Also provided is a composition comprising the cell, nucleic acid or oncolytic virus. 
     The present disclosure also provides an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, optionally isolated. Also provided is a nucleic acid encoding the antigen-binding molecule, optionally isolated. Also provided is a cell comprising the antigen-binding molecule, or comprising nucleic acid encoding the antigen-binding molecule, optionally isolated. Also provided is a composition comprising the cell, nucleic acid or antigen-binding molecule. 
     The present disclosure also provides a chimeric antigen receptor (CAR) as described herein, optionally isolated. Also provided is a nucleic acid encoding the CAR, optionally isolated. Also provided is a cell comprising the CAR, or comprising nucleic acid encoding the CAR, optionally isolated. Also provided is a composition comprising the cell, nucleic acid or CAR. 
     The present disclosure also provides an immunomodulatory factor (e.g. IL-12, anti-PD-L1 minibody), optionally isolated. Also provided is a nucleic acid encoding the immunomodulatory factor, optionally isolated. Also provided is a cell comprising the immunomodulatory factor, or comprising nucleic acid encoding the immunomodulatory factor, optionally isolated. Also provided is a composition comprising the cell, nucleic acid or immunomodulatory factor. 
     The virus (e.g. oncolytic virus, HDAd), antigen-binding molecule (e.g. BiTE), CAR, immunomodulatory factor (e.g. IL-12, anti-PD-L1 minibody), nucleic acid/plurality, cell/plurality, or combination according to the present disclosure may be formulated as pharmaceutical compositions for clinical use and may comprise a pharmaceutically acceptable carrier, diluent, excipient or adjuvant. Combinations of the present disclosure may be provided as a single composition, or may be provided as plural compositions comprising the components of the combination. 
     In accordance with the present disclosure methods are also provided for the production of pharmaceutically useful compositions, such methods of production may comprise one or more steps selected from: isolating a virus (e.g. oncolytic virus, HDAd), antigen-binding molecule (e.g. BiTE), CAR, immunomodulatory factor (e.g. IL-12, anti-PD-L1 minibody), nucleic acid/plurality, cell/plurality, composition or combination as described herein; and/or mixing a virus (e.g. oncolytic virus, HDAd), antigen-binding molecule (e.g. BiTE), CAR, immunomodulatory factor (e.g. IL-12, anti-PD-L1 minibody), nucleic acid/plurality, cell/plurality, composition or combination as described herein with a pharmaceutically acceptable carrier, adjuvant, excipient or diluent. 
     For example, a further aspect of the present disclosure relates to a method of formulating or producing a medicament or pharmaceutical composition for use in the treatment of a cancer, the method comprising formulating a pharmaceutical composition or medicament by mixing a virus (e.g. oncolytic virus, HDAd), antigen-binding molecule (e.g. BiTE), CAR, immunomodulatory factor (e.g. IL-12, anti-PD-L1 minibody), nucleic acid/plurality, cell/plurality, composition or combination as described herein with a pharmaceutically acceptable carrier, adjuvant, excipient or diluent. 
     The present disclosure also provides a kit of parts comprising one or more of a virus (e.g. oncolytic virus, HDAd), antigen-binding molecule (e.g. BiTE), CAR, immunomodulatory factor (e.g. IL-12, anti-PD-L1 minibody), nucleic acid/plurality, cell/plurality, composition or combination according to the present disclosure. In some embodiments the kit may have at least one container having a predetermined quantity of an article of the present disclosure. The kit may have containers containing individual components of the combinations of the present disclosure, or may have containers containing combinations of the components of the combinations of the present disclosure. 
     The kit may be provided with instructions for administration to a patient in order to treat a specified cancer. The article(s) may be formulated so as to be suitable for injection or infusion to a tumor or to the blood. 
     In some embodiments the kit may comprise materials for producing a cell according to the present disclosure. For example, the kit may comprise materials for modifying a cell to express or comprise a virus or an antigen/peptide thereof, CAR or nucleic acid/plurality of nucleic acids according to the present disclosure, or materials for introducing into a cell the virus or an antigen/peptide thereof or nucleic acid/plurality of nucleic acids according to the present disclosure. The kit may comprise materials for producing an immune cell specific for an oncolytic virus; for example, the kit may comprise pepmixes of one or more antigens of the oncolytic virus. 
     In some embodiments the kit may further comprise at least one container having a predetermined quantity of another therapeutic agent (e.g. anti-infective agent or chemotherapy agent). In such embodiments, the kit may also comprise a second medicament or pharmaceutical composition such that the two medicaments or pharmaceutical compositions may be administered simultaneously or separately such that they provide a combined treatment for the cancer. The therapeutic agent may also be formulated so as to be suitable for injection or infusion to a tumor or to the blood. 
     Therapeutic Applications 
     Aspects of the present disclosure are concerned with the use of (i) a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, (ii) an oncolytic virus, and/or (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen, in the treatment of a cancer in a subject. 
     Accordingly, the present disclosure provides a method of treating a cancer, comprising administering to a subject: (i) a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, (ii) an oncolytic virus, and/or (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. 
     The present disclosure also provides (i) a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, (ii) an oncolytic virus, and/or (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen, for use in a method of treating a cancer. Also provided is the use of (i) a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen, (ii) an oncolytic virus, and/or (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen; in the manufacture of a medicament for treating a cancer. 
     ‘Treatment’ may, for example, be reduction in the development or progression of a cancer, alleviation of the symptoms of a cancer or reduction in the pathology of a cancer. Treatment or alleviation of a cancer may be effective to prevent progression of the cancer, e.g. to prevent worsening of the condition or to slow the rate of development of a more severe disease state. In some embodiments treatment or alleviation may lead to an improvement in the cancer, e.g. a reduction in the symptoms of the cancer or reduction in some other correlate of the severity/activity of the cancer. Prevention of a cancer may refer to prevention of a worsening of the condition or prevention of the development of the cancer, e.g. preventing an early stage cancer developing to a later stage. 
     In some embodiments, the treatment may be aimed at reducing the number of cells of the cancer or the amount of tissue comprising cancerous cells in the subject. In some embodiments, the treatment may be aimed at reducing the size of and/or preventing the growth of a tumor in the subject. 
     In some embodiments, the treatment comprises administering a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure, to a subject. In some embodiments, the treatment comprises administering a cell or population of cells comprising or encoding a virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule, and (b) an antigen-binding moiety specific for a cancer cell antigen according to the present disclosure, to a subject. In some embodiments, the treatment is aimed at providing the subject with an antigen-binding molecule comprising according to the present disclosure. 
     In some embodiments, the treatment comprises administering an oncolytic virus according to the present disclosure to a subject. In some embodiments, the treatment comprises administering a cell or population of cells comprising or encoding an oncolytic virus according to the present disclosure to a subject. 
     In some embodiments, the treatment comprises administering a cell comprising a CAR described herein to a subject. In some embodiments, the treatment may comprise modifying a cell or population of cells to comprise/express a CAR according to the present disclosure. In some embodiments, the treatment may comprise administering to a subject a cell or population of cells modified to comprise/express a CAR of the present disclosure. In some embodiments, the treatment is aimed at providing the subject with an immune cell or population of immune cells which having specificity for a cancer cell antigen, e.g. by administering a CAR-expressing cell according to the present disclosure, or generating a CAR-expressing cell according to the present disclosure. 
     In some embodiments, the treatment may comprise administering to a subject an immune cell/population of immune cells specific for an oncolytic virus according to the present disclosure. In some embodiments, the treatment is aimed at providing the subject with an immune cell/population of immune cells having specificity for an oncolytic virus. In some embodiments, the treatment may comprise generating/expanding a population of immune cells specific for an oncolytic virus according to the present disclosure. 
     In some embodiments, the treatment may comprise administering to a subject an immune cell/population of immune cells specific for an oncolytic virus according to the present disclosure, modified to comprise/express a CAR according to the present disclosure. In some embodiments, the treatment is aimed at providing the subject with an immune cell/population of immune cells having specificity for an oncolytic virus also having specificity for a cancer cell antigen. In some embodiments, the treatment may comprise generating/expanding a population of immune cells specific for an oncolytic virus according to the present disclosure, and modifying a cell or cells of the population to comprise/express a CAR according to the present disclosure. 
     The subject to be treated may be any animal or human. The subject is preferably mammalian, more preferably human. The subject may be a non-human mammal, but is more preferably human. The subject may be male or female or of any gender. The subject may be a patient. A subject may have been diagnosed with a cancer requiring treatment, may be suspected of having such a cancer, or may be at risk of developing such a cancer. 
     In some embodiments, the cancer to be treated comprises cells expressing a cancer cell antigen, e.g. a cancer cell antigen as described herein. In some embodiments, the cells express the cancer cell antigen at the cell surface. In some embodiments, the cancer to be treated is or comprises a tumor comprising cells expressing a cancer cell antigen, e.g. a cancer cell antigen as described herein. 
     In some embodiments, the cancer to be treated comprises cells expressing a cancer cell antigen for which the CAR comprises a specific antigen-binding moiety. In some embodiments, the cancer to be treated comprises cells expressing a cancer cell antigen for which the antigen-binding molecule comprises a specific antigen-binding moiety. 
     In embodiments wherein the methods employ a virus encoding an antigen-binding molecule comprising an antigen-binding moiety specific for a cancer cell antigen and a CAR specific for a non-identical cancer cell antigen, the cancer to be treated may comprise cells expressing both of the cancer cell antigens. 
     In some embodiments, the cancer over-expresses the cancer cell antigen. Overexpression of a cancer cell antigen can be determined by detection of a level of expression of the cancer cell antigen which is greater than the level of expression by equivalent non-cancerous cells/non-tumor tissue. In some embodiments the cancer is a cancer expressing CD44v6, e.g. a cancer expressing CD44v6 at the cell surface. In some embodiments the cancer is selected from head and neck squamous cell carcinoma (HNSCC), prostate cancer, pancreatic cancer, breast cancer, colon cancer, gastric carcinoma, ovarian cancer, acute myeloid leukemia and multiple myeloma. 
     In some embodiments the cancer is a cancer expressing HER2, e.g. a cancer expressing HER2 at the cell surface. In some embodiments, the cancer over-expresses HER2. Overexpression of HER2 can be determined by detection of a level of expression of HER2 which is greater than the level of expression of HER2 by equivalent non-cancerous cells/non-tumor tissue. In some embodiments the cancer is selected from breast cancer, ovarian cancer, bladder cancer, salivary gland cancer, endometrial cancer, pancreatic cancer and non-small-cell lung cancer (NSCLC). 
     In some embodiments the cancer is a cancer expressing CD19, e.g. a cancer expressing CD19 at the cell surface. In some embodiments the cancer is selected from B cell lymphoma, acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL). 
     In some embodiments, the subject to be treated according to the present disclosure is selected for treatment on the basis detection of expression/overexpression of the cancer cell antigen by a cancer cell or tumour obtained from the subject. 
     Expression of a given cancer cell antigen may be determined by any suitable means. Expression may be gene expression or protein expression. Gene expression can be determined e.g. by detection of mRNA encoding the cancer cell antigen, for example by quantitative real-time PCR (q RT-PCR). Protein expression can be determined e.g. by detection of the cancer cell antigen, for example by antibody-based methods, for example by western blot, immunohistochemistry, immunocytochemistry, flow cytometry, or ELISA. 
     The cancer to be treated/prevented in accordance with the present disclosure may be any unwanted cell proliferation (or any disease manifesting itself by unwanted cell proliferation), neoplasm or tumor. The cancer may be benign or malignant and may be primary or secondary (metastatic). The cancer may be resistant (initially or following treatment) and/or the cancer may be recurring. A neoplasm or tumor may be any abnormal growth or proliferation of cells and may be located in any tissue. The cancer may be of tissues/cells derived from e.g. the adrenal gland, adrenal medulla, anus, appendix, bladder, blood, bone, bone marrow, brain, breast, cecum, central nervous system (including or excluding the brain) cerebellum, cervix, colon, duodenum, endometrium, epithelial cells (e.g. renal epithelia), gallbladder, oesophagus, glial cells, heart, ileum, jejunum, kidney, lacrimal glad, larynx, liver, lung, lymph, lymph node, lymphoblast, maxilla, mediastinum, mesentery, myometrium, nasopharynx, omentum, oral cavity, ovary, pancreas, parotid gland, peripheral nervous system, peritoneum, pleura, prostate, salivary gland, sigmoid colon, skin, small intestine, soft tissues, spleen, stomach, testis, thymus, thyroid gland, tongue, tonsil, trachea, uterus, vulva, white blood cells. 
     The cancer to be treated/prevented may be any kind of cancer, including any one of an acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), adrenocortical carcinoma, AIDS-related cancer (e.g. Kaposi sarcoma, AIDS-related lymphoma, primary CNS lymphoma), anal cancer, appendix cancer, astrocytoma, basal cell carcinoma of the skin, bile duct cancer (e.g. cholangiocarcinoma), bladder cancer, bone cancer (e.g. Ewing sarcoma, osteosarcoma, malignant fibrous histiocytoma), brain tumor, breast cancer, bronchial tumor, Burkitt lymphoma, carcinoid tumor, carcinoma of unknown primary, cardiac tumor, central nervous system cancer (e.g. atypical teratoid/rhabdoid tumor, embryonal tumor, germ cell tumor, primary CNS lymphoma), cervical cancer, chordoma, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), chronic myeloproliferative neoplasm, colorectal cancer, craniopharyngioma, cutaneous T-cell lymphoma (e.g. mycosis fungoides, Sézary syndrome), ductal carcinoma in situ (DCIS), endometrial cancer (uterine cancer), ependymoma, esophageal cancer, esthesioneuroblastoma, extracranial germ cell tumor, extragonadal germ cell tumor, eye cancer (e.g. intraocular melanoma, retinoblastoma) fallopian tube cancer, malignant fibrous histiocytoma of bone, gallbladder cancer, gastric (stomach) cancer, gastrointestinal carcinoid tumor, gastrointestinal stromal tumor (GIST), ovarian germ cell tumor, testicular cancer, gestational trophoblastic disease, hairy cell leukemia, head and neck cancer, heart tumor, hepatocellular (liver) cancer, histiocytosis, Langerhans cell, Hodgkin lymphoma, hypopharyngeal cancer, islet cell tumor (pancreatic neuroendocrine tumor), kidney (renal cell) cancer, laryngeal cancer, papillomatosis, leukemia, lip and oral cavity cancer, lung cancer (non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)) lymphoma, male breast cancer, melanoma, Merkel cell carcinoma, mesothelioma, metastatic cancer, metastatic squamous neck cancer with occult primary, midline tract carcinoma involving NUT gene, mouth cancer, multiple endocrine neoplasia syndromes, multiple myeloma/plasma cell neoplasms, mycosis fungoides, myelodysplastic syndrome, myelodysplastic/myeloproliferative neoplasm, myelogenous leukemia, chronic myeloid leukemia, acute myeloid leukemia (AML), nasal cavity and paranasal sinus cancer, nasopharyngeal cancer, neuroblastoma, non-Hodgkin lymphoma, oral cancer, lip and oral cavity cancer, oropharyngeal cancer, osteosarcoma, ovarian cancer, pancreatic cancer, papillomatosis, paraganglioma, paranasal sinus cancer, nasal cavity cancer, parathyroid cancer, penile cancer, pharyngeal cancer, pheochromocytoma, pituitary tumor, plasma cell neoplasm/multiple myeloma, pleuropulmonary blastoma, pregnancy and breast cancer, primary peritoneal cancer, prostate cancer, rectal cancer, recurrent cancer, retinoblastoma, rhabdomyosarcoma, salivary gland cancer, vascular tumor, uterine sarcoma, skin cancer, small intestine cancer, squamous cell carcinoma of the skin, T-cell lymphoma, throat cancer, thymoma, thymic carcinoma, thyroid cancer, transitional cell cancer of the renal pelvis and ureter, urethral cancer, vaginal cancer, vulvar cancer or Wilms tumor. 
     In some embodiments the cancer is associated with, or caused by, a virus (e.g. Epstein-Barr Vius, human papillomavirus (HPV), hepatitis B virus (HBV), etc.). In some embodiments the cancer is an EBV-positive cancer. In some embodiments the cancer is an HPV-positive cancer. In some embodiments the cancer is an HBV-positive cancer. 
     In some embodiments the cancer is selected from head and neck squamous cell carcinoma (HNSCC), prostate cancer, pancreatic cancer, breast cancer, colon cancer, gastric carcinoma, ovarian cancer, acute myeloid leukemia and multiple myeloma, bladder cancer, salivary gland cancer, endometrial cancer, non-small-cell lung cancer (NSCLC), B cell lymphoma, acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL). 
     In some embodiments the cancer is head and neck cancer (e.g. a cancer originating from tissues of the lip, mouth, nose, sinuses, pharynx or larynx), head and neck squamous cell carcinoma (HNSCC), nasopharyngeal carcinoma (NPC; e.g. EBV-positive NPC), oropharyngeal carcinoma (OPC; e.g. HPV-positive OPC), prostate carcinoma, pancreatic carcinoma, cervical carcinoma (e.g. HPV-positive CC), gastric carcinoma (GC; EBV-positive GC), hepatocellular carcinoma (HCC; e.g. HBV-positive HCC), osteosarcoma (OS), ovarian cancer, colorectal cancer, breast cancer (e.g. HER2-positive breast cancer), or lung cancer (e.g. non-small cell lung cancer (NSCLC)). 
     Methods of medical treatment may also involve in vivo, ex vivo, and adoptive immunotherapies, including those using autologous and/or heterologous cells or immortalized cell lines. 
     Administration 
     Administration is preferably in a “therapeutically effective amount”, this being sufficient to show benefit to the individual. The actual amount administered, and rate and time-course of administration, will depend on the nature and severity of the disease being treated. Prescription of treatment, e.g. decisions on dosage etc., is within the responsibility of general practitioners and other medical doctors, and typically takes account of the condition to be treated, the condition of the individual patient, the site of delivery, the method of administration and other factors known to practitioners. Examples of the techniques and protocols mentioned above can be found in Remington&#39;s Pharmaceutical Sciences, 20th Edition, 2000, pub. Lippincott, Williams &amp; Wilkins. 
     Articles according to the present disclosure (e.g. viruses (e.g. oncolytic viruses, HDAds), antigen-binding molecules (e.g. BiTEs), CARs, immunomodulatory factors (e.g. IL-12, anti-PD-L1 minibody), nucleic acids and cells) may be formulated as pharmaceutical compositions or medicaments for clinical use and may comprise a pharmaceutically acceptable carrier, diluent, excipient or adjuvant. Compositions may be formulated for topical, parenteral, systemic, intracavitary, intravenous, intra-arterial, intramuscular, intrathecal, intraocular, intraconjunctival, intratumoral, subcutaneous, intradermal, intrathecal, oral or transdermal routes of administration which may include injection or infusion. Suitable formulations may comprise the viruses, antigen-binding molecules, CARs, immunomodulatory factors, nucleic acids, or cells in sterile or isotonic medium. Medicaments and pharmaceutical compositions may be formulated in fluid, including gel, form. Fluid formulations may be formulated for administration by injection or infusion (e.g. via catheter) to a selected region of the human or animal body. 
     In some embodiments the viruses, antigen-binding molecules, CARs, immunomodulatory factors, nucleic acids, cells and/or compositions according to the present disclosure may be formulated for intratumoral administration, or for intravenous administration. 
     Administration of the components of combinations of the present disclosure may be simultaneous or sequential. The present disclosure also contemplates simultaneous or sequential administration of the components of combinations of the present disclosure. 
     Simultaneous administration refers to administration of the agents together, for example as a pharmaceutical composition containing the agents (i.e. a combined preparation), or immediately after each other and optionally via the same route of administration, e.g. to the same artery, vein or other blood vessel. In particular embodiments, the virus comprising nucleic acid encoding an antigen-binding molecule comprising: (a) an antigen-binding moiety specific for an immune cell surface molecule and an oncolytic virus may be administered simultaneously in a combined preparation. In some embodiments upon simultaneous administration two or more of the agents may be administered via different routes of administration. In some embodiments simultaneous administration refers to administration at the same time, or within e.g. 1 hr, 2 hrs, 3 hrs, 4 hrs, 5 hrs, 6 hrs, 8 hrs, 12 hrs, 24 hrs, 36 hrs or 48 hrs. 
     Sequential administration refers to administration of one or more of the agents followed after a given time interval by separate administration of another of the agents. It is not required that the two agents are administered by the same route, although this is the case in some embodiments. The time interval may be any time interval, including hours, days, weeks, months, or years. In some embodiments sequential administration refers to administrations separated by a time interval of one of at least 10 min, 30 min, 1 hr, 6 hrs, 8 hrs, 12 hrs, 24 hrs, 36 hrs, 48 hrs, 3 days, 4 days, 5 days, 6 days, 1 week, 2 weeks, 3 weeks, 1 month, 6 weeks, 2 months, 3 months, 4 months, 5 months or 6 months. 
     In some embodiments, the treatment may further comprise other therapeutic or prophylactic intervention, e.g. chemotherapy, immunotherapy, radiotherapy, surgery, vaccination and/or hormone therapy. Such other therapeutic or prophylactic intervention may occur before, during and/or after the therapies encompassed by the disclosure, and the deliveries of the other therapeutic or prophylactic interventions may occur via different administration routes as the therapies of the disclosure. Chemotherapy and radiotherapy respectively refer to treatment of a cancer with a drug or with ionising radiation (e.g. radiotherapy using X-rays or γ-rays). The drug may be a chemical entity, e.g. small molecule pharmaceutical, antibiotic, DNA intercalator, protein inhibitor (e.g. kinase inhibitor), or a biological agent, e.g. antibody, antibody fragment, nucleic acid or peptide aptamer, nucleic acid (e.g. DNA, RNA), peptide, polypeptide, or protein. The drug may be formulated as a pharmaceutical composition or medicament. The formulation may comprise one or more drugs (e.g. one or more active agents) together with one or more pharmaceutically acceptable diluents, excipients or carriers. 
     The chemotherapy may be administered by one or more routes of administration, e.g. parenteral, intravenous injection, oral, subcutaneous, intradermal or intratumoral. 
     The chemotherapy may be administered according to a treatment regime. The treatment regime may be a pre-determined timetable, plan, scheme or schedule of chemotherapy administration which may be prepared by a physician or medical practitioner and may be tailored to suit the patient requiring treatment. 
     The treatment regime may indicate one or more of: the type of chemotherapy to administer to the patient; the dose of each drug or radiation; the time interval between administrations; the length of each treatment; the number and nature of any treatment holidays, if any etc. For a co-therapy a single treatment regime may be provided which indicates how each drug is to be administered. 
     Chemotherapeutic drugs and biologics may be selected from: alkylating agents such as cisplatin, carboplatin, mechlorethamine, cyclophosphamide, chlorambucil, ifosfamide; purine or pyrimidine anti-metabolites such as azathiopurine or mercaptopurine; alkaloids and terpenoids, such as  vinca  alkaloids (e.g. vincristine, vinblastine, vinorelbine, vindesine), podophyllotoxin, etoposide, teniposide, taxanes such as paclitaxel (Taxol™), docetaxel; topoisomerase inhibitors such as the type I topoisomerase inhibitors camptothecins irinotecan and topotecan, or the type II topoisomerase inhibitors amsacrine, etoposide, etoposide phosphate, teniposide; antitumor antibiotics (e.g. anthracyline antibiotics) such as dactinomycin, doxorubicin (Adriamycin™), epirubicin, bleomycin, rapamycin; antibody based agents, such as anti-PD-1 antibodies, anti-PD-L1 antibodies, anti-TIM-3 antibodies, anti-CTLA-4, anti-4-1BB, anti-GITR, anti-CD27, anti-BLTA, anti-OX43, anti-VEGF, anti-TNFα, anti-IL-2, antiGpIIb/IIIa, anti-CD-52, anti-CD20, anti-RSV, anti-HER2/neu(erbB2), anti-TNF receptor, anti-EGFR antibodies, monoclonal antibodies or antibody fragments, examples include: cetuximab, panitumumab, infliximab, basiliximab, bevacizumab (Avastin®), abciximab, daclizumab, gemtuzumab, alemtuzumab, rituximab (Mabthera®), palivizumab, trastuzumab, etanercept, adalimumab, nimotuzumab; EGFR inhibitors such as erlotinib, cetuximab and gefitinib; anti-angiogenic agents such as bevacizumab (Avastin®); cancer vaccines such as Sipuleucel-T (Provenge®). 
     Further chemotherapeutic drugs may be selected from: 13-cis-Retinoic Acid, 2-Chlorodeoxyadenosine, 5-Azacitidine 5-Fluorouracil, 6-Mercaptopurine, 6-Thioguanine, Abraxane, Accutane®, Actinomycin-D Adriamycin®, Adrucil®, Afinitor®, Agrylin®, Ala-Cort®, Aldesleukin, Alemtuzumab, ALIMTA, Alitretinoin, Alkaban-AQ®, Alkeran®, All-transretinoic Acid, Alpha Interferon, Altretamine, Amethopterin, Amifostine, Aminoglutethimide, Anagrelide, Anandron®, Anastrozole, Arabinosylcytosine, Aranesp®, Aredia®, Arimidex®, Aromasin®, Arranon®, Arsenic Trioxide, Asparaginase, ATRA Avastin®, Azacitidine, BCG, BCNU, Bendamustine, Bevacizumab, Bexarotene, BEXXAR®, Bicalutamide, BiCNU, Blenoxane®, Bleomycin, Bortezomib, Busulfan, Busulfex®, Calcium Leucovorin, Campath®, Camptosar®, Camptothecin-11, Capecitabine, Carac™, Carboplatin, Carmustine, Casodex®, CC-5013, CCI-779, CCNU, CDDP, CeeNU, Cerubidine®, Cetuximab, Chlorambucil, Cisplatin, Citrovorum Factor, Cladribine, Cortisone, Cosmegen®, CPT-11, Cyclophosphamide, Cytadren®, Cytarabine Cytosar-U®, Cytoxan®, Dacogen, Dactinomycin, Darbepoetin Alfa, Dasatinib, Daunomycin, Daunorubicin, Daunorubicin Hydrochloride, Daunorubicin Liposomal, DaunoXome®, Decadron, Decitabine, Delta-Cortef®, Deltasone®, Denileukin, Diftitox, DepoCyt™, Dexamethasone, Dexamethasone Acetate, Dexamethasone Sodium Phosphate, Dexasone, Dexrazoxane, DHAD, DIC, Diodex, Docetaxel, Doxil®, Doxorubicin, Doxorubicin Liposomal, Droxia™, DTIC, DTIC-Dome®, Duralone®, Eligard™, Ellence™, Eloxatin™, Elspar®, Emcyt®, Epirubicin, Epoetin Alfa, Erbitux, Erlotinib,  Erwinia  L-asparaginase, Estramustine, Ethyol Etopophos®, Etoposide, Etoposide Phosphate, Eulexin®, Everolimus, Evista®, Exemestane, Faslodex®, Femora®, Filgrastim, Floxuridine, Fludara®, Fludarabine, Fluoroplex®, Fluorouracil, Fluoxymesterone, Flutamide, Folinic Acid, FUDR®, Fulvestrant, Gefitinib, Gemcitabine, Gemtuzumab ozogamicin, Gleevec™, Gliadel® Wafer, Goserelin, Granulocyte—Colony Stimulating Factor, Granulocyte Macrophage Colony Stimulating Factor, Herceptin®, Hexadrol, Hexalen®, Hexamethylmelamine, HMM, Hycamtin®, Hydrea®, Hydrocort Acetate®, Hydrocortisone, Hydrocortisone Sodium Phosphate, Hydrocortisone Sodium Succinate, Hydrocortone Phosphate, Hydroxyurea, Ibritumomab, Ibritumomab Tiuxetan, Idamycin®, Idarubicin, Ifex®, IFN-alpha, Ifosfamide, IL-11, IL-2, Imatinib mesylate, Imidazole Carboxamide, Interferon alfa, Interferon Alfa-2b (PEG Conjugate), Interleukin-2, Interleukin-11, Intron A® (interferon alfa-2b), Iressa®, Irinotecan, Isotretinoin, Ixabepilone, Ixempra™, Kidrolase, Lanacort®, Lapatinib, L-asparaginase, LCR, Lenalidomide, Letrozole, Leucovorin, Leukeran, Leukine™, Leuprolide, Leurocristine, Leustatin™, Liposomal Ara-C, Liquid Pred®, Lomustine, L-PAM, L-Sarcolysin, Lupron®, Lupron Depot®, Matulane®, Maxidex, Mechlorethamine, Mechlorethamine Hydrochloride, Medralone®, Medrol®, Megace®, Megestrol, Megestrol Acetate, Melphalan, Mercaptopurine, Mesna, Mesnex™ Methotrexate, Methotrexate Sodium, Methylprednisolone, Meticorten®, Mitomycin, Mitomycin-C, Mitoxantrone, M-Prednisol®, MTC, MTX, Mustargen®, Mustine, Mutamycin®, Myleran®, Mylocel™, Mylotarg®, Navelbine®, Nelarabine, Neosar®, Neulasta™, Neumega®, Neupogen®, Nexavar®, Nilandron®, Nilutamide, Nipent®, Nitrogen Mustard, Novaldex®, Novantrone®, Octreotide, Octreotide acetate, Oncospar®, Oncovin®, Ontak®, Onxal™, Oprevelkin, Orapred®, Orasone®, Oxaliplatin, Paclitaxel, Paclitaxel Protein-bound, Pamidronate, Panitumumab, Panretin®, Paraplatin®, Pediapred®, PEG Interferon, Pegaspargase, Pegfilgrastim, PEG-INTRON™, PEG-L-asparaginase, PEMETREXED, Pentostatin, Phenylalanine Mustard, Platinol®, Platinol-AQ®, Prednisolone, Prednisone, Prelone®, Procarbazine, PROCRIT®, Proleukin®, Prolifeprospan 20 with Carmustine Implant Purinethol®, Raloxifene, Revlimid®, Rheumatrex®, Rituxan®, Rituximab, Roferon-A® (Interferon Alfa-2a), Rubex®, Rubidomycin hydrochloride, Sandostatin® Sandostatin LAR®, Sargramostim, Solu-Cortef®, Solu-Medrol®, Sorafenib, SPRYCEL™, STI-571, Streptozocin, SU11248, Sunitinib, Sutent®, Tamoxifen, Tarceva®, Targretin®, Taxol®, Taxotere®, Temodar®, Temozolomide, Temsirolimus, Teniposide, TESPA, Thalidomide, Thalomid®, TheraCys®, Thioguanine, Thioguanine Tabloid®, Thiophosphoamide, Thioplex®, Thiotepa, TICE®, Toposar®, Topotecan, Toremifene, Torisel®, Tositumomab, Trastuzumab, Treanda®, Tretinoin, Trexall™, Trisenox®, TSPA, TYKERB®, VCR, Vectibix™, Velban®, Velcade®, VePesid®, Vesanoid®, Viadur™, Vidaza®, Vinblastine, Vinblastine Sulfate, Vincasar Pfs®, Vincristine, Vinorelbine, Vinorelbine tartrate, VLB, VM-26, Vorinostat, VP-16, Vumon®, Xeloda®, Zanosar®, Zevalin™, Zinecard®, Zoladex®, Zoledronic acid, Zolinza, Zometa®. 
     In embodiments of the present disclosure wherein a nucleic acid/virus encoding an enzyme capable of catalysing conversion of a non-toxic factor to a cytotoxic form is employed, the method may further comprise administration with a prodrug substrate for the enzyme. The prodrug may be administered simultaneously or sequentially to administration of the nucleic acid/virus encoding an enzyme capable of catalysing conversion of a non-toxic factor to a cytotoxic form. 
     In some embodiments the prodrug is selected from ganciclovir (GCV), aciclovir (ACV) and/or valaciclovir, e.g. where the nucleic acid/virus encodes a thymidine kinase. In some embodiments the prodrug is 5-fluorocytosine (5-FC), e.g. where the nucleic acid/virus encodes a cytosine deaminase. In some embodiments the prodrug is selected from CB1954, nitro-CBI-DEI and/or PR-104A, e.g. where the nucleic acid/virus encodes a nitroreductase. In some embodiments the prodrug is oxazaphosphorine (e.g. cyclophosphamide or ifosfamide), e.g. where the nucleic acid/virus encodes a cytochrome P450. In some embodiments the prodrug is a nitrogen mustard based drug (e.g. CMDA or ZD2767P), e.g. where the nucleic acid/virus encodes a carboxypeptidase G2. In some embodiments the prodrug is 6-methylpurine 2-deoxyriboside and/or fludarabine (e.g. 6-methylpurine-2′-deoxyriboside (MeP-d R), 2-F-2′-deoxyadenosine (F-dAdo) or arabinofuranosyl-2-F-adenine monophosphate (F-araAMP), e.g. where the nucleic acid/virus encodes a purine nucleoside phosphorylase. In some embodiments the prodrug is indole-3-acetic acid (IAA), e.g. where the nucleic acid/virus encodes a horseradish peroxidase. In some embodiments the prodrug is irinotecan, e.g. where the nucleic acid/virus encodes a carboxylesterase. 
     Multiple doses of the articles of the present disclosure (e.g. viruses (e.g. oncolytic viruses, HDAds), antigen-binding molecules (e.g. BiTEs), CARs, immunomodulatory factors (e.g. IL-12, anti-PD-L1 minibody), nucleic acids, cells compositions, combinations) of the present disclosure may be provided. One or more, or each, of the doses may be accompanied by simultaneous or sequential administration of another therapeutic agent. 
     Multiple doses may be separated by a predetermined time interval, which may be selected to be one of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or more hours or 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, or 31 days, or 1, 2, 3, 4, 5, or 6 months. By way of example, doses may be given once every 7, 14, 21 or 28 days (plus or minus 3, 2, or 1 days). 
     Adoptive Transfer 
     In embodiments of the present disclosure, the methods of treatment comprise adoptive transfer of immune cells. Adoptive cell transfer (ACT) generally refers to a process by which cells (e.g. immune cells) are obtained from a subject, typically by drawing a blood sample from which the cells are isolated. The cells are then typically treated or altered in some way, and then administered either to the same subject (adoptive transfer is of autologous cells) or to a different subject (adoptive transfer is of allogeneic cells). The treatment is typically aimed at providing population of cells with certain desired characteristics to a subject, or increasing the frequency of cells with such characteristics in that subject. In the present disclosure, adoptive transfer may be performed with the aim of introducing a cell or population of cells into a subject, and/or increasing the frequency of a cell or population of cells in a subject. 
     In some embodiments, the subject from which the cell is isolated is the subject administered with the modified cell (i.e., adoptive transfer is of autologous cells). In some embodiments, the subject from which the cell is isolated is a different subject to the subject to which the modified cell is administered (i.e., adoptive transfer is of allogeneic cells). 
     Adoptive transfer of T cells is described, for example, in Kalos and June 2013, Immunity 39(1): 49-60, which is hereby incorporated by reference in its entirety. Adoptive transfer of NK cells is described, for example, in Davis et al. 2015, Cancer J. 21(6): 486-491, which is hereby incorporated by reference in its entirety. 
     The cell may e.g. be a neutrophil, eosinophil, basophil, dendritic cell, lymphocyte, or monocyte. The lymphocyte may be e.g. a T cell, B cell, NK cell, NKT cell or innate lymphoid cell (ILC), or a precursor thereof. In some embodiments, the cell is a T cell. In some embodiments, the T cell is a CD3+ T cell. In some embodiments, the T cell is a CD3+, CD4+ T cell. In some embodiments, the T cell is a CD3+, CD8+ T cell. In some embodiments, the T cell is a T helper cell (T H  cell)). In some embodiments, the T cell is a cytotoxic T cell (e.g. a cytotoxic T lymphocyte (CTL)). In some embodiments, the T cell is a virus-specific T cell. In some embodiments, the T cell is specific for EBV, HPV, HBV, HCV or sHIV. 
     In some embodiments the cell is an immune cell specific for an oncolytic virus, as described herein. Accordingly, in some embodiments the methods comprise administration of at least one immune cell specific for an oncolytic virus to a subject. In some embodiments, the methods of the disclosure comprise generating/expanding a population of immune cells specific for an oncolytic virus, and administering at least one immune cell specific for the oncolytic virus to a subject. 
     In some embodiments, the methods comprise:
         (a) isolating immune cells from a subject;   (b) generating or expanding a population of immune cells specific for an oncolytic virus by a method comprising: stimulating the immune cells by culture in the presence of antigen presenting cells (APCs) presenting a peptide of the oncolytic virus, and;   (c) administering at least one immune cell specific for the oncolytic virus to a subject.       

     In some embodiments the method steps for production of an immune cell specific for an oncolytic virus may comprise one or more of: taking a blood sample from a subject; isolating PBMCs from the blood sample; generating/expanding a population of immune cells specific for an oncolytic virus (e.g. by culturing PBMCs in the presence of cells (e.g. APCs) comprising/expressing antigen(s)/peptide(s) of the oncolytic virus); culturing immune cells specific for an oncolytic virus in in vitro or ex vivo cell culture; collecting immune cells specific for an oncolytic virus; mixing immune cells specific for an oncolytic virus with an adjuvant, diluent, or carrier; administering the modified cell to a subject. 
     In some embodiments the methods of the present disclosure comprise administering at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen to a subject. In connection with this feature of the disclosure, in some embodiments, the method additionally comprises steps for production of the at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. The CAR may be a first generation, second generation or third or subsequent generation CAR. The CAR may comprise one, two, three, or more costimulatory domains, for example. 
     In some embodiments, the methods comprise modifying at least one cell obtained from a subject to express or comprise a CAR according to the disclosure, optionally expanding the modified at least one cell, and administering the modified at least one cell to a subject. 
     In some embodiments, the methods comprise:
         (a) isolating at least one cell from a subject;   (b) modifying the at least one cell to express or comprise a CAR according to the present disclosure, or a nucleic acid encoding a CAR according to the present disclosure,   (c) optionally expanding the modified at least one cell, and;   (d) administering the modified at least one cell to a subject.       

     In some embodiments the cell comprising/expressing a CAR specific for a cancer cell antigen is an immune cell specific for an oncolytic virus, as described herein. In some embodiments, the methods comprise modifying an immune cell specific for an oncolytic virus to express or comprise a CAR according to the disclosure, optionally expanding the modified immune cell specific for an oncolytic virus, and administering the modified immune cell specific for an oncolytic virus to a subject. 
     In some embodiments, the methods comprise:
         (a) isolating immune cells from a subject;   (b) generating or expanding a population of immune cells specific for an oncolytic virus by a method comprising: stimulating the immune cells by culture in the presence of antigen presenting cells (APCs) presenting a peptide of the oncolytic virus;   (c) modifying at least one immune cell specific for an oncolytic virus to express or comprise a CAR according to the present disclosure, or a nucleic acid encoding a CAR according to the present disclosure,   (d) optionally expanding the modified at least one immune cell specific for an oncolytic virus, and;   (e) administering the modified at least one immune cell specific for an oncolytic virus to a subject.       

     The at least one cell modified according to the present disclosure can be modified to comprise/express a CAR according to methods well known to the skilled person. The modification may comprise nucleic acid transfer for permanent or transient expression of the transferred nucleic acid. Any suitable genetic engineering platform may be used to modify a cell according to the present disclosure. Suitable methods for modifying a cell include the use of genetic engineering platforms such as gammaretroviral vectors, lentiviral vectors, adenovirus vectors, DNA transfection, transposon-based gene delivery and RNA transfection, for example as described in Maus et al., Annu Rev Immunol (2014) 32:189-225, incorporated by reference hereinabove. 
     In some embodiments the method steps for production of the at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen may comprise one or more of: taking a blood sample from a subject; isolating and/or expanding at least one cell from the blood sample; culturing the at least one cell in in vitro or ex vivo cell culture; introducing into the at least one cell a CAR as described herein, or a nucleic acid encoding a CAR as described herein, thereby modifying the at least one cell; expanding the at least one modified cell; collecting the at least one modified cell; mixing the modified cell with an adjuvant, diluent, or carrier; administering the modified cell to a subject. 
     In some embodiments, the methods may additionally comprise treating the cell to induce/enhance expression of the CAR or nucleic acid encoding the CAR. For example, the nucleic acid may comprise a control element for inducible upregulation of expression of the CAR from the nucleic acid in response to treatment with a particular agent. In some embodiments, treatment may be in vivo by administration of the agent to a subject having been administered with a modified cell according to the disclosure. In some embodiments, treatment may be ex vivo or in vitro by administration of the agent to cells in culture ex vivo or in vitro. 
     The skilled person is able to determine appropriate reagents and procedures for adoptive transfer of cells according to the present disclosure, for example by reference to Dai et al., 2016 J Nat Cancer Inst 108(7): djv439, which is incorporated by reference in its entirety. 
     In a related aspect, the present disclosure provides a method of preparing a modified cell, the method comprising introducing into a cell a CAR according to the present disclosure or a nucleic acid encoding a CAR according to the present disclosure, thereby modifying the at least one cell. The method is preferably performed in vitro or ex vivo. 
     Sequence Identity 
     Pairwise and multiple sequence alignment for the purposes of determining percent identity between two or more amino acid or nucleic acid sequences can be achieved in various ways known to a person of skill in the art, for instance, using publicly available computer software such as ClustalOmega (Söding, J. 2005, Bioinformatics 21, 951-960), T-coffee (Notredame et al. 2000, J. Mol. Biol. (2000) 302, 205-217), Kalign (Lassmann and Sonnhammer 2005, BMC Bioinformatics, 6(298)) and MAFFT (Katoh and Standley 2013, Molecular Biology and Evolution, 30(4) 772-780 software. When using such software, the default parameters, e.g. for gap penalty and extension penalty, are preferably used. 
     
       
         
           
               
            
               
                   
               
               
                 Sequences 
               
            
           
           
               
               
               
            
               
                 SEQ 
                   
                   
               
               
                 ID NO. 
                 DESCRIPTION 
                 SEQUENCE 
               
               
                   
               
            
           
           
               
               
               
            
               
                 1 
                 HER2(C5)- 
                 QVQLQESGPGLVKPSETLSLTCTVSGGSISSSSYYWGWIRQPPGKGLEWIGSIYYSGST 
               
               
                   
                 CD28TM, ICD- 
                 YYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARYAPDSSGYLVAFDIWGQGT 
               
               
                   
                 CD3Z CAR 
                 MVTVSSGGGGSGGGGSGGGGSQTVVTQEPSFSVSPGGTVTLTCGLSSGSVSTGYYPS 
               
               
                   
                   
                 WYQQTPGQAPRTLIYSTNSRSSGVPDRFSGSILGNKAALTITGAQADDESDYYCVLYMG 
               
               
                   
                   
                 SGISVFGGGTKLTVLGSEPKSCDKTHTCPTRFWVLVVVGGVLACYSLLVTVAFIIFWVRS 
               
               
                   
                   
                 KRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRSRVKFSRSADAPAYQQGQN 
               
               
                   
                   
                 QLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSEI 
               
               
                   
                   
                 GMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 
               
               
                   
               
               
                 2 
                 HER2(E4)- 
                 QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTN 
               
               
                   
                 CD28TM, ICD- 
                 YNPSLKSRVTISVDTSKNQFSLKLSSVTTADTAVYYCARMGINSGGYLYGMDVWGQGTT 
               
               
                   
                 CD3Z CAR 
                 VTVSSGGGGSGGGGSGGGGSQTVVTQEPSFSVSPGGTVTLTCGLSSGSVSTSYYPSW 
               
               
                   
                   
                 YQQIPGQAPRTLIYTTNIRSSGVPDRFGGSILGNKAALTITGAQAEDESDYYCMLYMGSGI 
               
               
                   
                   
                 WVFGGGTKLTVLGSEPKSCDKTHTCPTRFWVLVVVGGVLACYSLLVTVAFIIFWVRSKR 
               
               
                   
                   
                 SRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRSRVKFSRSADAPAYQQGQNQL 
               
               
                   
                   
                 YNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSEIGM 
               
               
                   
                   
                 KGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 
               
               
                   
               
               
                 3 
                 HER2(F1)- 
                 QVQLVESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGST 
               
               
                   
                 CD28TM, ICD- 
                 NYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARMGANSGGYLYGMDVWGQG 
               
               
                   
                 CD3Z CAR 
                 TTVTVSSGGGGSGGGGSGGGGSQTVVTQEPSFSVSPGGTVTLTCGLSSGSVSTSYYP 
               
               
                   
                   
                 SWYQQTPGQAPRTLIYSTNTRSSGVPDRFSGSILGNKAALTITGAQADDESDYYCVLYM 
               
               
                   
                   
                 GSGIWVFGGGTKLTVLGSEPKSCDKTHTCPTRFWVLVVVGGVLACYSLLVTVAFIIFWVR 
               
               
                   
                   
                 SKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRSRVKFSRSADAPAYQQGQ 
               
               
                   
                   
                 NQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSE 
               
               
                   
                   
                 IGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 
               
               
                   
               
               
                 4 
                 HER2(A3)- 
                 QLVQSGTEVKKPGASVRVSCKSSGYTFTSYYIHWVRQAPGQGLEWMAIINPGNGDTNY 
               
               
                   
                 CD28TM, ICD- 
                 AQRFQGRVTMTRDTSTSTVYMELRSLRSDDTAVYFCAREIASYSGSYYDYWGQGTLVT 
               
               
                   
                 CD3Z CAR 
                 VSSGGGGSGGGGSGGGGSQAVVLQEPSLSVSPGGTVTLTCGLSSGSVSTGHYASWY 
               
               
                   
                   
                 QQTPGQAPRTLFYNTNTRSSGVPDRFSGSIVGNKAALTITGAQADDESDYYCVLYVGDG 
               
               
                   
                   
                 IWVFGGGTKLTVLEPKSCDKTHTCPTRFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSR 
               
               
                   
                   
                 LLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRSRVKFSRSADAPAYQQGQNQLYN 
               
               
                   
                   
                 ELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSEIGMKG 
               
               
                   
                   
                 ERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 
               
               
                   
               
               
                 5 
                 CD28 TMD 
                 FWVLVVVGGVLACYSLLVTVAFIIFWV 
               
               
                   
               
               
                 6 
                 CD28 ICD 
                 RSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS 
               
               
                   
               
               
                 7 
                 CD3Z ICD 
                 RVKFSRSADAPAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQ 
               
               
                   
                   
                 EGLYNELQKDKMAEAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR 
               
               
                   
               
               
                 8 
                 Hinge 
                 EPKSCDKTHTCPTR 
               
               
                   
               
               
                 9 
                 HER2(C5) LC- 
                 GLSSGSVSTGYYPS 
               
               
                   
                 CDR1 
                   
               
               
                   
               
               
                 10 
                 HER2(C5) LC- 
                 STNSRSS 
               
               
                   
                 CDR2 
                   
               
               
                   
               
               
                 11 
                 HER2(C5) LC- 
                 VLYMGSGISV 
               
               
                   
                 CDR3 
                   
               
               
                   
               
               
                 12 
                 HER2(C5) HC- 
                 SSSYYWG 
               
               
                   
                 CDR1 
                   
               
               
                   
               
               
                 13 
                 HER2(C5) HC- 
                 SIYYSGSTYYNPSLKS 
               
               
                   
                 CDR2 
                   
               
               
                   
               
               
                 14 
                 HER2(C5) HC- 
                 YAPDSSGYLVAFDI 
               
               
                   
                 CDR3 
                   
               
               
                   
               
               
                 15 
                 HER2(C5) VL 
                 QTVVTQEPSFSVSPGGTVTLTCGLSSGSVSTGYYPSWYQQTPGQAPRTLIYSTNSRSS 
               
               
                   
                   
                 GVPDRFSGSILGNKAALTITGAQADDESDYYCVLYMGSGISVFGGGTKLTVLGS 
               
               
                   
               
               
                 16 
                 HER2(C5) VH 
                 QVQLQESGPGLVKPSETLSLTCTVSGGSISSSSYYWGWIRQPPGKGLEWIGSIYYSGST 
               
               
                   
                   
                 YYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARYAPDSSGYLVAFDIWGQGT 
               
               
                   
                   
                 MVTVSS 
               
               
                   
               
               
                 17 
                 HER2(E4) LC- 
                 GLSSGSVSTSYYPS 
               
               
                   
                 CDR1 
                   
               
               
                   
               
               
                 18 
                 HER2(E4) LC- 
                 TTNIRSS 
               
               
                   
                 CDR2 
                   
               
               
                   
               
               
                 19 
                 HER2(E4) LC- 
                 MLYMGSGIWV 
               
               
                   
                 CDR3 
                   
               
               
                   
               
               
                 20 
                 HER2(E4) HC- 
                 SGYYWS 
               
               
                   
                 CDR1 
                   
               
               
                   
               
               
                 21 
                 HER2(E4) HC- 
                 EINHSGSTNYNPSLKS 
               
               
                   
                 CDR2 
                   
               
               
                   
               
               
                 22 
                 HER2(E4) HC- 
                 MGINSGGYLYGMDV 
               
               
                   
                 CDR3 
                   
               
               
                   
               
               
                 23 
                 HER2(E4) VL 
                 QTVVTQEPSFSVSPGGTVTLTCGLSSGSVSTSYYPSWYQQIPGQAPRTLIYTTNIRSSGV 
               
               
                   
                   
                 PDRFGGSILGNKAALTITGAQAEDESDYYCMLYMGSGIWVFGGGTKLTVLGS 
               
               
                   
               
               
                 24 
                 HER2(E4) VH 
                 QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGSTN 
               
               
                   
                   
                 YNPSLKSRVTISVDTSKNQFSLKLSSVTTADTAVYYCARMGINSGGYLYGMDVWGQGTT 
               
               
                   
                   
                 VTVSS 
               
               
                   
               
               
                 25 
                 HER2(F1) LC- 
                 GLSSGSVSTSYYPS 
               
               
                   
                 CDR1 
                   
               
               
                   
               
               
                 26 
                 HER2(F1) LC- 
                 STNTRSS 
               
               
                   
                 CDR2 
                   
               
               
                   
               
               
                 27 
                 HER2(F1) LC- 
                 VLYMGSGIWV 
               
               
                   
                 CDR3 
                   
               
               
                   
               
               
                 28 
                 HER2(F1) HC- 
                 SSNWWS 
               
               
                   
                 CDR1 
                   
               
               
                   
               
               
                 29 
                 HER2(F1) HC- 
                 EIYHSGSTNYNPSLKS 
               
               
                   
                 CDR2 
                   
               
               
                   
               
               
                 30 
                 HER2(F1) HC- 
                 MGANSGGYLYGMDV 
               
               
                   
                 CDR3 
                   
               
               
                   
               
               
                 31 
                 HER2(F1) VL 
                 QTVVTQEPSFSVSPGGTVTLTCGLSSGSVSTSYYPSWYQQTPGQAPRTLIYSTNTRSSG 
               
               
                   
                   
                 VPDRFSGSILGNKAALTITGAQADDESDYYCVLYMGSGIWVFGGGTKLTVLGS 
               
               
                   
               
               
                 32 
                 HER2(F1) VH 
                 QVQLVESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGST 
               
               
                   
                   
                 NYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARMGANSGGYLYGMDVWGQG 
               
               
                   
                   
                 TTVTVSS 
               
               
                   
               
               
                 33 
                 HER2(A3) LC- 
                 GLSSGSVSTGHYAS 
               
               
                   
                 CDR1 
                   
               
               
                   
               
               
                 34 
                 HER2(A3) LC- 
                 NTNTRSS 
               
               
                   
                 CDR2 
                   
               
               
                   
               
               
                 35 
                 HER2(A3) LC- 
                 VLYVGDGIWV 
               
               
                   
                 CDR3 
                   
               
               
                   
               
               
                 36 
                 HER2(A3) HC- 
                 SYYIHWVRQA 
               
               
                   
                 CDR1 
                   
               
               
                   
               
               
                 37 
                 HER2(A3) HC- 
                 IINPGNGDTNYAQRFQG 
               
               
                   
                 CDR2 
                   
               
               
                   
               
               
                 38 
                 HER2(A3) HC- 
                 EIASYSGSYYDY 
               
               
                   
                 CDR3 
                   
               
               
                   
               
               
                 39 
                 HER2(A3) VL 
                 QAVVLQEPSLSVSPGGTVTLTCGLSSGSVSTGHYASWYQQTPGQAPRTLFYNTNTRSS 
               
               
                   
                   
                 GVPDRFSGSIVGNKAALTITGAQADDESDYYCVLYVGDGIWVFGGGTKLTVL 
               
               
                   
               
               
                 40 
                 HER2(A3) VH 
                 EVQLVQSGTEVKKPGASVRVSCKSSGYTFTSYYIHWVRQAPGQGLEWMAIINPGNGDT 
               
               
                   
                   
                 NYAQRFQGRVTMTRDTSTSTVYMELRSLRSDDTAVYFCAREIASYSGSYYDYWGQGTL 
               
               
                   
                   
                 VTVSS 
               
               
                   
               
               
                 41 
                 huIL-12p70 
                 MGHQQLVISWFSLVFLASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGIT 
               
               
                   
                   
                 WTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKD 
               
               
                   
                   
                 QKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAE 
               
               
                   
                   
                 RVRGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPP 
               
               
                   
                   
                 KNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSA 
               
               
                   
                   
                 TVICRKNASISVRAQDRYYSSSWSEWASVPCSVPGVGVPGVGARNLPVATPDPGMFPC 
               
               
                   
                   
                 LHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACLPLELTKNESCL 
               
               
                   
                   
                 NSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQ 
               
               
                   
                   
                 NMLAVIDELMQALNFNSETVPQKSSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS 
               
               
                   
               
               
                 42 
                 HSV1 TK 
                 MASYPGHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGP 
               
               
                   
                   
                 HGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDA 
               
               
                   
                   
                 AVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYL 
               
               
                   
                   
                 MGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVY 
               
               
                   
                   
                 GLLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPEL 
               
               
                   
                   
                 LAPNGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMIQTHVTTPG 
               
               
                   
                   
                 SIPTICDLARTFAREMGEAN 
               
               
                   
               
               
                 43 
                 PD-L1(H12_gl) 
                 EVQLVQSGAEVKKPGASVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGRIIPILGIAN 
               
               
                   
                 minibody 
                 YAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARSGHGYSYGAFDYWGQGTLV 
               
               
                   
                   
                 TVSSGGGGSGGGGSGGGGSQSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWY 
               
               
                   
                   
                 QQLPGTAPKLLIYGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSL 
               
               
                   
                   
                 SGSYVVFGGGTKLTVLEAKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEV 
               
               
                   
                   
                 TCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNG 
               
               
                   
                   
                 KEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDI 
               
               
                   
                   
                 AVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHN 
               
               
                   
                   
                 HYTQKSLSLSPGK 
               
               
                   
               
               
                 44 
                 PD-L1(H12_gl) 
                 TGSSSNIGAGYDVH 
               
               
                   
                 LC-CDR1 
                   
               
               
                   
               
               
                 45 
                 PD-L1(H12_gl) 
                 GNSNRPS 
               
               
                   
                 LC-CDR2 
                   
               
               
                   
               
               
                 46 
                 PD-L1(H12_gl) 
                 QSYDSSLSGSYVV 
               
               
                   
                 LC-CDR3 
                   
               
               
                   
               
               
                 47 
                 PD-L1(H12_gl) 
                 SYAIS 
               
               
                   
                 HC-CDR1 
                   
               
               
                   
               
               
                 48 
                 PD-L1(H12_gl) 
                 RIIPILGIANYAQKFQG 
               
               
                   
                 HC-CDR2 
                   
               
               
                   
               
               
                 49 
                 PD-L1(H12_gl) 
                 SGHGYSYGAFDY 
               
               
                   
                 HC-CDR3 
                   
               
               
                   
               
               
                 50 
                 PD-L1(H12_gl) 
                 QSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGNSNRPSG 
               
               
                   
                 VL 
                 VPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGSYVVFGGGTKLTVL 
               
               
                   
               
               
                 51 
                 PD-L1(H12_gl) 
                 EVQLVQSGAEVKKPGASVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGRIIPILGIAN 
               
               
                   
                 VH 
                 YAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARSGHGYSYGAFDYWGQGTLV 
               
               
                   
                   
                 TVSS 
               
               
                   
               
               
                 52 
                 PD-L1 
                 EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWISPYGGS 
               
               
                   
                 (YW243.55.S70) 
                 TYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVT 
               
               
                   
                 minibody 
                 VSAGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQK 
               
               
                   
                   
                 PGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYHPATFG 
               
               
                   
                   
                 QGTKVEIKREAKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDV 
               
               
                   
                   
                 SHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKV 
               
               
                   
                   
                 SNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWES 
               
               
                   
                   
                 NGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSL 
               
               
                   
                   
                 SLSPGK 
               
               
                   
               
               
                 53 
                 PD-L1 
                 QDVSTA 
               
               
                   
                 (YW243.55.S70) 
                   
               
               
                   
                 LC-CDR1 
                   
               
               
                   
               
               
                 54 
                 PD-L1 
                 SAS 
               
               
                   
                 (YW243.55.S70) 
                   
               
               
                   
                 LC-CDR2 
                   
               
               
                   
               
               
                 55 
                 PD-L1 
                 QQYLYHPAT 
               
               
                   
                 (YW243.55.S70) 
                   
               
               
                   
                 LC-CDR3 
                   
               
               
                   
               
               
                 56 
                 PD-L1 
                 GFTFSDSW 
               
               
                   
                 (YW243.55.S70) 
                   
               
               
                   
                 HC-CDR1 
                   
               
               
                   
               
               
                 57 
                 PD-L1 
                 ISPYGGST 
               
               
                   
                 (YW243.55.S70) 
                   
               
               
                   
                 HC-CDR2 
                   
               
               
                   
               
               
                 58 
                 PD-L1 
                 ARRHWPGGFDY 
               
               
                   
                 (YW243.55.S70) 
                   
               
               
                   
                 HC-CDR3 
                   
               
               
                   
               
               
                 59 
                 PD-L1 
                 DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVP 
               
               
                   
                 (YW243.55.S70) 
                 SRFSGSGSGTDFTLTISSLQPEDFATYYCQQYLYHPATFGQGTKVEIK 
               
               
                   
                 VL 
                   
               
               
                   
               
               
                 60 
                 PD-L1 
                 EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWISPYGGS 
               
               
                   
                 (YW243.55.S70) 
                 TYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVT 
               
               
                   
                 VH 
                 VS 
               
               
                   
               
               
                 61 
                 IgG1 hinge 
                 KSCDKTHTCP 
               
               
                   
               
               
                 62 
                 hIgG1 CH2 
                 PCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHN 
               
               
                   
                   
                 AKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK 
               
               
                   
               
               
                 63 
                 hIgG1 CH3 
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLD 
               
               
                   
                   
                 SDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK 
               
               
                   
               
               
                 64 
                 anti-CD44v6 
                 EIVLTQSPATLSLSPGERATLSCSASSSINYIYWLQQKPGQAPRILIYLTSNLASGVPARFS 
               
               
                   
                 BiTE 
                 GSGSGTDFTLTISSLEPEDFAVYYCLQWSSNPLTFGGGTKVEIKRGGGGSGGGGSGGG 
               
               
                   
                   
                 GSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVS 
               
               
                   
                   
                 TISSGGSYTYYLDSIKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQGLDYWGRGT 
               
               
                   
                   
                 LVTVSSGGGGGSDIKLQQSGAELARPGASVKMSCKTSGYTFTRYTMHWVKQRPGQGL 
               
               
                   
                   
                 EWIGYINPSRGYTNYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYDDHY 
               
               
                   
                   
                 CLDYWGQGTTLTVSSGGGGSGGGGSGGGGSDIQLTQSPAIMSASPGEKVTMTCRASS 
               
               
                   
                   
                 SVSYMNWYQQKSGTSPKRWIYDTSKVASGVPYRFSGSGSGTSYSLTISSMEAEDAATY 
               
               
                   
                   
                 YCQQWSSNPLTFGAGTKLELK 
               
               
                   
               
               
                 65 
                 anti-CD44v6 
                 EIVLTQSPATLSLSPGERATLSCSASSSINYIYWLQQKPGQAPRILIYLTSNLASGVPARFS 
               
               
                   
                 (BIWA8) scFv 
                 GSGSGTDFTLTISSLEPEDFAVYYCLQWSSNPLTFGGGTKVEIKRGGGGSGGGGSGGG 
               
               
                   
                   
                 GSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVS 
               
               
                   
                   
                 TISSGGSYTYYLDSIKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQGLDYWGRGT 
               
               
                   
                   
                 LVTVSS 
               
               
                   
               
               
                 66 
                 anti-CD44v6 
                 SSINY 
               
               
                   
                 (BIWA8) 
                   
               
               
                   
                 LC-CDR1 
                   
               
               
                   
               
               
                 67 
                 anti-CD44v6 
                 LTS 
               
               
                   
                 (BIWA8) 
                   
               
               
                   
                 LC-CDR2 
                   
               
               
                   
               
               
                 68 
                 anti-CD44v6 
                 LQWSSNPLT 
               
               
                   
                 (BIWA8) 
                   
               
               
                   
                 LC-CDR3 
                   
               
               
                   
               
               
                 69 
                 anti-CD44v6 
                 GFTFSSYD 
               
               
                   
                 (BIWA8) 
                   
               
               
                   
                 HC-CDR1 
                   
               
               
                   
               
               
                 70 
                 anti-CD44v6 
                 ISSGGSYT 
               
               
                   
                 (BIWA8) 
                   
               
               
                   
                 HC-CDR2 
                   
               
               
                   
               
               
                 71 
                 anti-CD44v6 
                 ARQGLDY 
               
               
                   
                 (BIWA8) 
                   
               
               
                   
                 HC-CDR3 
                   
               
               
                   
               
               
                 72 
                 anti-CD44v6 
                 EIVLTQSPATLSLSPGERATLSCSASSSINYIYWLQQKPGQAPRILIYLTSNLASGVPARFS 
               
               
                   
                 (BIWA8) VL 
                 GSGSGTDFTLTISSLEPEDFAVYYCLQWSSNPLTFGGGTKVEIK 
               
               
                   
               
               
                 73 
                 anti-CD44v6 
                 EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVSTISSGGSYT 
               
               
                   
                 (BIWA8) VH 
                 YYLDSIKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQGLDYWGRGTLVTVSS 
               
               
                   
               
               
                 74 
                 anti-CD3 (OKT3) 
                 DIKLQQSGAELARPGASVKMSCKTSGYTFTRYTMHWVKQRPGQGLEWIGYINPSRGYT 
               
               
                   
                 scFv 
                 NYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYDDHYCLDYWGQGTTLT 
               
               
                   
                   
                 VSSGGGGSGGGGSGGGGSDIQLTQSPAIMSASPGEKVTMTCRASSSVSYMNWYQQK 
               
               
                   
                   
                 SGTSPKRWIYDTSKVASGVPYRFSGSGSGTSYSLTISSMEAEDAATYYCQQWSSNPLTF 
               
               
                   
                   
                 GAGTKLELK 
               
               
                   
               
               
                 75 
                 anti-CD3 (OKT3) 
                 SSVSY 
               
               
                   
                 LC-CDR1 
                   
               
               
                   
               
               
                 78 
                 anti-CD3 (OKT3) 
                 DTS 
               
               
                   
                 LC-CDR2 
                   
               
               
                   
               
               
                 77 
                 anti-CD3 (OKT3) 
                 QQWSSNPLT 
               
               
                   
                 LC-CDR3 
                   
               
               
                   
               
               
                 78 
                 anti-CD3 (OKT3) 
                 GYTFTRYT 
               
               
                   
                 HC-CDR1 
                   
               
               
                   
               
               
                 79 
                 anti-CD3 (OKT3) 
                 INPSRGYT 
               
               
                   
                 HC-CDR2 
                   
               
               
                   
               
               
                 80 
                 anti-CD3 (OKT3) 
                 ARYYDDHYCLDY 
               
               
                   
                 HC-CDR3 
                   
               
               
                   
               
               
                 81 
                 anti-CD3 (OKT3) 
                 DIQLTQSPAIMSASPGEKVTMTCRASSSVSYMNWYQQKSGTSPKRWIYDTSKVASGVP 
               
               
                   
                 VL 
                 YRFSGSGSGTSYSLTISSMEAEDAATYYCQQWSSNPLTFGAGTKLELK 
               
               
                   
               
               
                 82 
                 anti-CD3 (OKT3) 
                 DIKLQQSGAELARPGASVKMSCKTSGYTFTRYTMHWVKQRPGQGLEWIGYINPSRGYT 
               
               
                   
                 VH 
                 NYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYDDHYCLDYWGQGTTLT 
               
               
                   
                   
                 VSS 
               
               
                   
               
               
                 83 
                 anti-HER2 BiTE 
                 EVQLQQSGPELKKPGETVKISCKASGYPFTNYGMNWVKQAPGQGLKWMGWINTSTGE 
               
               
                   
                   
                 STFADDFKGRFDFSLETSANTAYLQINNLKSEDMATYFCARWEVYHGYVPYWGQGTTV 
               
               
                   
                   
                 TVSSGGGGSGGGGSGGGGSDIQLTQSHKFLSTSVGDRVSITCKASQDVYNAVAWYQQ 
               
               
                   
                   
                 KPGQSPKLLIYSASSRYTGVPSRFTGSGSGPDFTFTISSVQAEDLAVYFCQQHFRTPFTF 
               
               
                   
                   
                 GSGTKLEIKALGGGGSDIKLQQSGAELARPGASVKMSCKTSGYTFTRYTMHWVKQRPG 
               
               
                   
                   
                 QGLEWIGYINPSRGYTNYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYD 
               
               
                   
                   
                 DHYCLDYWGQGTTLTVSSGGGGSGGGGSGGGGSDIQLTQSPAIMSASPGEKVTMTCR 
               
               
                   
                   
                 ASSSVSYMNWYQQKSGTSPKRWIYDTSKVASGVPYRFSGSGSGTSYSLTISSMEAEDA 
               
               
                   
                   
                 ATYYCQQWSSNPLTFGAGTKLELK 
               
               
                   
               
               
                 84 
                 anti-HER2 (FRP5) 
                 EVQLQQSGPELKKPGETVKISCKASGYPFTNYGMNWVKQAPGQGLKWMGWINTSTGE 
               
               
                   
                 scFv 
                 STFADDFKGRFDFSLETSANTAYLQINNLKSEDMATYFCARWEVYHGYVPYWGQGTTV 
               
               
                   
                   
                 TVSSGGGGSGGGGSGGGGSDIQLTQSHKFLSTSVGDRVSITCKASQDVYNAVAWYQQ 
               
               
                   
                   
                 KPGQSPKLLIYSASSRYTGVPSRFTGSGSGPDFTFTISSVQAEDLAVYFCQQHFRTPFTF 
               
               
                   
                   
                 GSGTKLEIK 
               
               
                   
               
               
                 85 
                 anti-HER2 (FRP5) 
                 QDVYNA 
               
               
                   
                 LC-CDR1 
                   
               
               
                   
               
               
                 86 
                 anti-HER2 (FRP5) 
                 SAS 
               
               
                   
                 LC-CDR2 
                   
               
               
                   
               
               
                 87 
                 anti-HER2 (FRP5) 
                 QQHFRTPFT 
               
               
                   
                 LC-CDR3 
                   
               
               
                   
               
               
                 88 
                 anti-HER2 (FRP5) 
                 GYPFTNYG 
               
               
                   
                 HC-CDR1 
                   
               
               
                   
               
               
                 89 
                 anti-HER2 (FRP5) 
                 INTSTGES 
               
               
                   
                 HC-CDR2 
                   
               
               
                   
               
               
                 90 
                 anti-HER2 (FRP5) 
                 ARWEVYHGYVPY 
               
               
                   
                 HC-CDR3 
                   
               
               
                   
               
               
                 91 
                 anti-HER2 (FRP5) 
                 DIQLTQSHKFLSTSVGDRVSITCKASQDVYNAVAWYQQKPGQSPKLLIYSASSRYTGVP 
               
               
                   
                 VL 
                 SRFTGSGSGPDFTFTISSVQAEDLAVYFCQQHFRTPFTFGSGTKLEIK 
               
               
                   
               
               
                 92 
                 anti-HER2 (FRP5) 
                 EVQLQQSGPELKKPGETVKISCKASGYPFTNYGMNWVKQAPGQGLKWMGWINTSTGE 
               
               
                   
                 VH 
                 STFADDFKGRFDFSLETSANTAYLQINNLKSEDMATYFCARWEVYHGYVPYWGQGTTV 
               
               
                   
                   
                 TVSS 
               
               
                   
               
               
                 93 
                 anti-CD19 BiTE 
                 DIQMTQTTSSLSASLGDRVTISCRASQDISKYLNWYQQKPDGTVKLLIYHTSRLHSGVPS 
               
               
                   
                   
                 RFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPYTFGGGTKLEITGGGGSGGGGSGG 
               
               
                   
                   
                 GGSEVKLQESGPGLVAPSQSLSVTCTVSGVSLPDYGVSWIRQPPRKGLEWLGVIWGSE 
               
               
                   
                   
                 TTYYNSALKSRLTIIKDNSKSQVFLKMNSLQTDDTAIYYCAKHYYYGGSYAMDYWGQGT 
               
               
                   
                   
                 SVTVSSGGGGGSDIKLQQSGAELARPGASVKMSCKTSGYTFTRYTMHWVKQRPGQGL 
               
               
                   
                   
                 EWIGYINPSRGYTNYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYDDHY 
               
               
                   
                   
                 CLDYWGQGTTLTVSSGGGGSGGGGSGGGGSDIQLTQSPAIMSASPGEKVTMTCRASS 
               
               
                   
                   
                 SVSYMNWYQQKSGTSPKRWIYDTSKVASGVPYRFSGSGSGTSYSLTISSMEAEDAATY 
               
               
                   
                   
                 YCQQWSSNPLTFGAGTKLELK 
               
               
                   
               
               
                 94 
                 anti-CD19 
                 DIQMTQTTSSLSASLGDRVTISCRASQDISKYLNWYQQKPDGTVKLLIYHTSRLHSGVPS 
               
               
                   
                 (FMC63) scFv 
                 RFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPYTFGGGTKLEITGGGGSGGGGSGG 
               
               
                   
                   
                 GGSEVKLQESGPGLVAPSQSLSVTCTVSGVSLPDYGVSWIRQPPRKGLEWLGVIWGSE 
               
               
                   
                   
                 TTYYNSALKSRLTIIKDNSKSQVFLKMNSLQTDDTAIYYCAKHYYYGGSYAMDYWGQGT 
               
               
                   
                   
                 SVTVSS 
               
               
                   
               
               
                 95 
                 anti-CD19 
                 QDISKY 
               
               
                   
                 (FMC63) 
                   
               
               
                   
                 LC-CDR1 
                   
               
               
                   
               
               
                 96 
                 anti-CD19 
                 HTS 
               
               
                   
                 (FMC63) 
                   
               
               
                   
                 LC-CDR2 
                   
               
               
                   
               
               
                 97 
                 anti-CD19 
                 QQGNTLPYT 
               
               
                   
                 (FMC63) 
                   
               
               
                   
                 LC-CDR3 
                   
               
               
                   
               
               
                 98 
                 anti-CD19 
                 GVSLPDYG 
               
               
                   
                 (FMC63) 
                   
               
               
                   
                 HC-CDR1 
                   
               
               
                   
               
               
                 99 
                 anti-CD19 
                 IWGSETT 
               
               
                   
                 (FMC63) 
                   
               
               
                   
                 HC-CDR2 
                   
               
               
                   
               
               
                 100 
                 anti-CD19 
                 AKHYYYGGSYAMDY 
               
               
                   
                 (FMC63) 
                   
               
               
                   
                 HC-CDR3 
                   
               
               
                   
               
               
                 101 
                 anti-CD19 
                 DIQMTQTTSSLSASLGDRVTISCRASQDISKYLNWYQQKPDGTVKLLIYHTSRLHSGVPS 
               
               
                   
                 (FMC63) VL 
                 RFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPYTFGGGTKLEIT 
               
               
                   
               
               
                 102 
                 anti-CD19 
                 EVKLQESGPGLVAPSQSLSVTCTVSGVSLPDYGVSWIRQPPRKGLEWLGVIWGSETTY 
               
               
                   
                 (FMC63) VH 
                 YNSALKSRLTIIKDNSKSQVFLKMNSLQTDDTAIYYCAKHYYYGGSYAMDYWGQGTSVT 
               
               
                   
                   
                 VSS 
               
               
                   
               
               
                 103 
                 HER2 BiTE_CD44 
                 EIVLTQSPATLSLSPGERATLSCSASSSINYIYWLQQKPGQAPRILIYLTSNLASGVPARFS 
               
               
                   
                 v6BiTE fusion 
                 GSGSGTDFTLTISSLEPEDFAVYYCLQWSSNPLTFGGGTKVEIKRGGGGSGGGGSGGG 
               
               
                   
                   
                 GSGGGGSEVQLVESGGGLVKPGGSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVS 
               
               
                   
                   
                 TISSGGSYTYYLDSIKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARQGLDYWGRGT 
               
               
                   
                   
                 LVTVSSGGGGGSDIKLQQSGAELARPGASVKMSCKTSGYTFTRYTMHWVKQRPGQGL 
               
               
                   
                   
                 EWIGYINPSRGYTNYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCARYYDDHY 
               
               
                   
                   
                 CLDYWGQGTTLTVSSGGGGSGGGGSGGGGSDIQLTQSPAIMSASPGEKVTMTCRASS 
               
               
                   
                   
                 SVSYMNWYQQKSGTSPKRWIYDTSKVASGVPYRFSGSGSGTSYSLTISSMEAEDAATY 
               
               
                   
                   
                 YCQQWSSNPLTFGAGTKLELKSEGRGSLLTCGDVEENPGPSMDWIWRILFLVGAATGA 
               
               
                   
                   
                 HSEVQLQQSGPELKKPGETVKISCKASGYPFTNYGMNWVKQAPGQGLKWMGWINTST 
               
               
                   
                   
                 GESTFADDFKGRFDFSLETSANTAYLQINNLKSEDMATYFCARWEVYHGYVPYWGQGT 
               
               
                   
                   
                 TVTVSSGGGGSGGGGSGGGGSDIQLTQSHKFLSTSVGDRVSITCKASQDVYNAVAWY 
               
               
                   
                   
                 QQKPGQSPKLLIYSASSRYTGVPSRFTGSGSGPDFTFTISSVQAEDLAVYFCQQHFRTP 
               
               
                   
                   
                 FTFGSGTKLEIKALGGGGSDIKLQQSGAELARPGASVKMSCKTSGYTFTRYTMHWVKQ 
               
               
                   
                   
                 RPGQGLEWIGYINPSRGYTNYNQKFKDKATLTTDKSSSTAYMQLSSLTSEDSAVYYCAR 
               
               
                   
                   
                 YYDDHYCLDYWGQGTTLTVSSGGGGSGGGGSGGGGSDIQLTQSPAIMSASPGEKVTM 
               
               
                   
                   
                 TCRASSSVSYMNWYQQKSGTSPKRWIYDTSKVASGVPYRFSGSGSGTSYSLTISSMEA 
               
               
                   
                   
                 EDAATYYCQQWSSNPLTFGAGTKLELK 
               
               
                   
               
               
                 104 
                 Ad2 E1AΔ24 
                 MRHIICHGGVITEEMAASLLDQLIEEVLADNLPPPSHFEPPTLHELYDLDVTAPEDPNEEA 
               
               
                   
                   
                 VSQIFPESVMLAVQEGIDLFTFPPAPGSPEPPHLSRQPEQPEQRALGPVSMPNLVPEVID 
               
               
                   
                   
                 PPSDDEDEEGEEFVLDYVEHPGHGCRSCHYHRRNTGDPDIMCSLCYMRTCGMFVYSP 
               
               
                   
                   
                 VSEPEPEPEPEPEPARPTRRPKLVPAILRRPTSPVSRECNSSTDSCDSGPSNTPPEIHPV 
               
               
                   
                   
                 VPLCPIKPVAVRVGGRRQAVECIEDLLNESGQPLDLSCKRPRP 
               
               
                   
               
               
                 105 
                 Amino acids 121- 
                 LTCHEACF 
               
               
                   
                 128 of Ad E1A 
                   
               
               
                   
                 protein 
                   
               
               
                   
               
               
                 106 
                 SignalP 1 
                 MDWIWRILFLVGAATGAHS 
               
               
                   
               
               
                 107 
                 SignalP 2 
                 MEAPAQLLFLLLLWLPDTTG 
               
               
                   
               
               
                 108 
                 SignalP 3 
                 MGHQQLVISWFSLVFLASPLVA 
               
               
                   
               
               
                 109 
                 G4S linker 
                 GGGGS 
               
               
                   
               
               
                 110 
                 (G4S)2 linker 
                 GGGGSGGGGS 
               
               
                   
               
               
                 111 
                 (G4S)3 linker 
                 GGGGSGGGGSGGGGS 
               
               
                   
               
               
                 112 
                 (G4S)4 linker 
                 GGGGSGGGGSGGGGSGGGGS 
               
               
                   
               
               
                 113 
                 HA tag 
                 YPYDVPDYA 
               
               
                   
               
               
                 114 
                 3xHA tag 
                 YPYDVPDYAGYPYDVPDYAGYPYDVPDYA 
               
               
                   
               
               
                 115 
                 T2A peptide 
                 EGRGSLLTCGDVEENPGP 
               
               
                   
               
               
                 116 
                 2A cleavage 
                 X 1 EX 2 NPGP 
               
               
                   
                 sequence 
                 WHEREIN X 1  = V OR I, AND X 2  = S OR E 
               
               
                   
                 consensus 
                   
               
               
                   
               
               
                 117 
                 HER2(C5)- 
                 AAGTTCAGATCAAGGTCAGGAACAGATGGAACAGCTGAATATGGGCCAAACAGGAT 
               
               
                   
                 CD28TM, ICD- 
                 ATCTGTGGTAAGCAGTTCCTGCCCCGGCTCAGGGCCAAGAACAGATGGAACAGCTG 
               
               
                   
                 CD3Z CAR 
                 AATATGGGCCAAACAGGATATCTGTGGTAAGCAGTTCCTGCCCCGGCTCAGGGCCA 
               
               
                   
                   
                 AGAACAGATGGTCCCCAGATGCGGTCCAGCCCTCAGCAGTTTCTAGAGAACCATCA 
               
               
                   
                   
                 GATGTTTCCAGGGTGCCCCAAGGACCTGAAATGACCCTGTGCCTTATTTGAACTAAC 
               
               
                   
                   
                 CAATCAGTTCGCTTCTCGCTTCTGTTCGCGCGCTTCTGCTCCCCGAGCTCAATAAAA 
               
               
                   
                   
                 GAGCCCACAACCCCTCACTCGGCGCGCCAGTCCTCCGATTGACTGAGTCGCCCGG 
               
               
                   
                   
                 GTACCCGTGTATCCAATAAACCCTCTTGCAGTTGCATCCGACTTGTGGTCTCGCTGT 
               
               
                   
                   
                 TCCTTGGGAGGGTCTCCTCTGAGTGATTGACTACCCGTCAGCGGGGGTCTTTCATTT 
               
               
                   
                   
                 GGGGGCTCGTCCGGGATCGGGAGACCCCTGCCCAGGGACCACCGACCCACCACC 
               
               
                   
                   
                 GGGAGGTAAGCTGGCCAGCAACTTATCTGTGTCTGTCCGATTGTCTAGTGTCTATGA 
               
               
                   
                   
                 CTGATTTTATGCGCCTGCGTCGGTACTAGTTAGCTAACTAGCTCTGTATCTGGCGGA 
               
               
                   
                   
                 CCCGTGGTGGAACTGACGAGTTCGGAACACCCGGCCGCAACCCTGGGAGACGTCC 
               
               
                   
                   
                 CAGGGACTTCGGGGGCCGTTTTTGTGGCCCGACCTGAGTCCTAAAATCCCGATCGT 
               
               
                   
                   
                 TTAGGACTCTTTGGTGCACCCCCCTTAGAGGAGGGATATGTGGTTCTGGTAGGAGA 
               
               
                   
                   
                 CGAGAACCTAAAACAGTTCCCGCCTCCGTCTGAATTTTTGCTTTCGGTTTGGGACCG 
               
               
                   
                   
                 AAGCCGCGCCGCGCGTCTTGTCTGCTGCAGCATCGTTCTGTGTTGTCTCTGTCTGA 
               
               
                   
                   
                 CTGTGTTTCTGTATTTGTCTGAAAATATGGGCCCGGGCTAGCCTGTTACCACTCCCT 
               
               
                   
                   
                 TAAGTTTGACCTTAGGTCACTGGAAAGATGTCGAGCGGATCGCTCACAACCAGTCG 
               
               
                   
                   
                 GTAGATGTCAAGAAGAGACGTTGGGTTACCTTCTGCTCTGCAGAATGGCCAACCTTT 
               
               
                   
                   
                 AACGTCGGATGGCCGCGAGACGGCACCTTTAACCGAGACCTCATCACCCAGGTTAA 
               
               
                   
                   
                 GATCAAGGTCTTTTCACCTGGCCCGCATGGACACCCAGACCAGGTCCCCTACATCG 
               
               
                   
                   
                 TGACCTGGGAAGCCTTGGCTTTTGACCCCCCTCCCTGGGTCAAGCCCTTTGTACAC 
               
               
                   
                   
                 CCTAAGCCTCCGCCTCCTCTTCCTCCATCCGCCCCGTCTCTCCCCCTTGAACCTCCT 
               
               
                   
                   
                 CGTTCGACCCCGCCTCGATCCTCCCTTTATCCAGCCCTCACTCCTTCTCTAGGCGCC 
               
               
                   
                   
                 CCCATATGGCCATATGAGATCTTATATGGGGCACCCCCGCCCCTTGTAAACTTCCCT 
               
               
                   
                   
                 GACCCTGACATGACAAGAGTTACTAACAGCCCCTCTCTCCAAGCTCACTTACAGGCT 
               
               
                   
                   
                 CTCTACTTAGTCCAGCACGAAGTCTGGAGACCTCTGGCGGCAGCCTACCAAGAACA 
               
               
                   
                   
                 ACTGGACCGACCGGTGGTACCTCACCCTTACCGAGTCGGCGACACAGTGTGGGTCC 
               
               
                   
                   
                 GCCGACACCAGACTAAGAACCTAGAACCTCGCTGGAAAGGACCTTACACAGTCCTG 
               
               
                   
                   
                 CTGACCACCCCCACCGCCCTCAAAGTAGACGGCATCGCAGCTTGGATACACGCCGC 
               
               
                   
                   
                 CCACGTGAAGGCTGCCGACCCCGGGGGTGGACCATGACTCGAGCCATGGATTGGA 
               
               
                   
                   
                 TCTGGCGCATCCTGTTTCTCGTGGGAGCTGCCACAGGCGCCCATTCTCAGGTTCAG 
               
               
                   
                   
                 CTGCAAGAGTCTGGCCCTGGCCTGGTCAAGCCTAGCGAAACACTGAGCCTGACCTG 
               
               
                   
                   
                 TACCGTGTCTGGCGGCAGCATCAGCAGCAGCTCTTACTACTGGGGCTGGATCAGAC 
               
               
                   
                   
                 AGCCTCCTGGCAAAGGCCTGGAATGGATCGGCTCCATCTACTACAGCGGCAGCACC 
               
               
                   
                   
                 TACTACAACCCCAGCCTGAAGTCCAGAGTGACCATCAGCGTGGACACCAGCAAGAA 
               
               
                   
                   
                 CCAGTTCTCCCTGAAGCTGAGCAGCGTGACAGCCGCCGATACAGCCGTGTACTACT 
               
               
                   
                   
                 GTGCCAGATACGCCCCTGATAGCAGCGGCTACCTGGTGGCCTTTGATATCTGGGGC 
               
               
                   
                   
                 CAGGGCACAATGGTCACCGTTTCTAGCGGAGGCGGAGGTTCTGGTGGCGGAGGAA 
               
               
                   
                   
                 GTGGCGGCGGAGGATCTCAGACAGTGGTCACACAAGAGCCCAGCTTCTCCGTGTCT 
               
               
                   
                   
                 CCTGGCGGAACAGTGACCCTGACATGTGGCCTTAGCTCTGGCTCTGTGTCCACCGG 
               
               
                   
                   
                 CTACTACCCCAGCTGGTATCAGCAGACACCTGGACAGGCCCCTCGGACACTGATCT 
               
               
                   
                   
                 ACAGCACCAACAGCAGATCCAGCGGCGTGCCCGATAGATTCAGCGGCTCTATCCTG 
               
               
                   
                   
                 GGCAACAAGGCCGCACTGACAATCACAGGCGCTCAGGCCGATGACGAGAGCGACT 
               
               
                   
                   
                 ACTACTGCGTGCTGTACATGGGCAGCGGCATCTCCGTTTTTGGCGGAGGCACAAAG 
               
               
                   
                   
                 CTGACCGTGCTGGGATCCGAACCAAAGAGTTGCGACAAAACACACACCTGCCCTAC 
               
               
                   
                   
                 GCGTTTTTGGGTGCTCGTGGTGGTGGGTGGCGTGCTCGCTTGCTACTCACTTCTGG 
               
               
                   
                   
                 TGACCGTAGCGTTTATCATTTTTTGGGTCAGGAGCAAGCGATCCCGCCTATTGCACA 
               
               
                   
                   
                 GCGACTACATGAACATGACCCCCCGGCGCCCCGGGCCAACCCGGAAGCACTACCA 
               
               
                   
                   
                 GCCATATGCGCCTCCCCGCGATTTCGCAGCGTATCGGTCCCGGGTCAAATTTTCAC 
               
               
                   
                   
                 GGTCCGCTGACGCCCCGGCCTATCAACAGGGCCAGAATCAGCTGTATAATGAATTA 
               
               
                   
                   
                 AACCTCGGTAGACGCGAGGAGTACGACGTCCTCGACAAGAGAAGGGGGCGCGACC 
               
               
                   
                   
                 CAGAGATGGGAGGCAAACCGCAGCGCAGGAAGAATCCACAGGAGGGCCTGTACAA 
               
               
                   
                   
                 CGAATTACAGAAGGACAAGATGGCAGAGGCCTACAGCGAGATAGGAATGAAGGGTG 
               
               
                   
                   
                 AAAGGCGTCGTGGAAAGGGCCACGATGGGCTTTACCAGGGCCTAAGTACTGCCACA 
               
               
                   
                   
                 AAAGATACGTATGACGCGCTGCATATGCAAGCCCTCCCCCCCAGGTAAGCATGCAA 
               
               
                   
                   
                 CCTCGATCCGGATTAGTCCAATTTGTTAAAGACAGGATATCAGTGGTCCAGGCTCTA 
               
               
                   
                   
                 GTTTTGACTCAACAATATCACCAGCTGAAGCCTATAGAGTACGAGCCATAGATAAAAT 
               
               
                   
                   
                 AAAAGATTTTATTTAGTCTCCAGAAAAAGGGGGGAATGAAAGACCCCACCTGTAGGT 
               
               
                   
                   
                 TTGGCAAGCTAGCTTAAGTAACGCCATTTTGCAAGGCATGGAAAAATACATAACTGA 
               
               
                   
                   
                 GAATAGAGAAGTTCAGATCAAGGTCAGGAACAGATGGAACAGCTGAATATGGGCCA 
               
               
                   
                   
                 AACAGGATATCTGTGGTAAGCAGTTCCTGCCCCGGCTCAGGGCCAAGAACAGATGG 
               
               
                   
                   
                 AACAGCTGAATATGGGCCAAACAGGATATCTGTGGTAAGCAGTTCCTGCCCCGGCT 
               
               
                   
                   
                 CAGGGCCAAGAACAGATGGTCCCCAGATGCGGTCCAGCCCTCAGCAGTTTCTAGAG 
               
               
                   
                   
                 AACCATCAGATGTTTCCAGGGTGCCCCAAGGACCTGAAATGACCCTGTGCCTTATTT 
               
               
                   
                   
                 GAACTAACCAATCAGTTCGCTTCTCGCTTCTGTTCGCGCGCTTC 
               
               
                   
               
               
                 118 
                 HER2(E4)- 
                 AAGTTCAGATCAAGGTCAGGAACAGATGGAACAGCTGAATATGGGCCAAACAGGAT 
               
               
                   
                 CD28TM, ICD- 
                 ATCTGTGGTAAGCAGTTCCTGCCCCGGCTCAGGGCCAAGAACAGATGGAACAGCTG 
               
               
                   
                 CD3Z CAR 
                 AATATGGGCCAAACAGGATATCTGTGGTAAGCAGTTCCTGCCCCGGCTCAGGGCCA 
               
               
                   
                   
                 AGAACAGATGGTCCCCAGATGCGGTCCAGCCCTCAGCAGTTTCTAGAGAACCATCA 
               
               
                   
                   
                 GATGTTTCCAGGGTGCCCCAAGGACCTGAAATGACCCTGTGCCTTATTTGAACTAAC 
               
               
                   
                   
                 CAATCAGTTCGCTTCTCGCTTCTGTTCGCGCGCTTCTGCTCCCCGAGCTCAATAAAA 
               
               
                   
                   
                 GAGCCCACAACCCCTCACTCGGCGCGCCAGTCCTCCGATTGACTGAGTCGCCCGG 
               
               
                   
                   
                 GTACCCGTGTATCCAATAAACCCTCTTGCAGTTGCATCCGACTTGTGGTCTCGCTGT 
               
               
                   
                   
                 TCCTTGGGAGGGTCTCCTCTGAGTGATTGACTACCCGTCAGCGGGGGTCTTTCATTT 
               
               
                   
                   
                 GGGGGCTCGTCCGGGATCGGGAGACCCCTGCCCAGGGACCACCGACCCACCACC 
               
               
                   
                   
                 GGGAGGTAAGCTGGCCAGCAACTTATCTGTGTCTGTCCGATTGTCTAGTGTCTATGA 
               
               
                   
                   
                 CTGATTTTATGCGCCTGCGTCGGTACTAGTTAGCTAACTAGCTCTGTATCTGGCGGA 
               
               
                   
                   
                 CCCGTGGTGGAACTGACGAGTTCGGAACACCCGGCCGCAACCCTGGGAGACGTCC 
               
               
                   
                   
                 CAGGGACTTCGGGGGCCGTTTTTGTGGCCCGACCTGAGTCCTAAAATCCCGATCGT 
               
               
                   
                   
                 TTAGGACTCTTTGGTGCACCCCCCTTAGAGGAGGGATATGTGGTTCTGGTAGGAGA 
               
               
                   
                   
                 CGAGAACCTAAAACAGTTCCCGCCTCCGTCTGAATTTTTGCTTTCGGTTTGGGACCG 
               
               
                   
                   
                 AAGCCGCGCCGCGCGTCTTGTCTGCTGCAGCATCGTTCTGTGTTGTCTCTGTCTGA 
               
               
                   
                   
                 CTGTGTTTCTGTATTTGTCTGAAAATATGGGCCCGGGCTAGCCTGTTACCACTCCCT 
               
               
                   
                   
                 TAAGTTTGACCTTAGGTCACTGGAAAGATGTCGAGCGGATCGCTCACAACCAGTCG 
               
               
                   
                   
                 GTAGATGTCAAGAAGAGACGTTGGGTTACCTTCTGCTCTGCAGAATGGCCAACCTTT 
               
               
                   
                   
                 AACGTCGGATGGCCGCGAGACGGCACCTTTAACCGAGACCTCATCACCCAGGTTAA 
               
               
                   
                   
                 GATCAAGGTCTTTTCACCTGGCCCGCATGGACACCCAGACCAGGTCCCCTACATCG 
               
               
                   
                   
                 TGACCTGGGAAGCCTTGGCTTTTGACCCCCCTCCCTGGGTCAAGCCCTTTGTACAC 
               
               
                   
                   
                 CCTAAGCCTCCGCCTCCTCTTCCTCCATCCGCCCCGTCTCTCCCCCTTGAACCTCCT 
               
               
                   
                   
                 CGTTCGACCCCGCCTCGATCCTCCCTTTATCCAGCCCTCACTCCTTCTCTAGGCGCC 
               
               
                   
                   
                 CCCATATGGCCATATGAGATCTTATATGGGGCACCCCCGCCCCTTGTAAACTTCCCT 
               
               
                   
                   
                 GACCCTGACATGACAAGAGTTACTAACAGCCCCTCTCTCCAAGCTCACTTACAGGCT 
               
               
                   
                   
                 CTCTACTTAGTCCAGCACGAAGTCTGGAGACCTCTGGCGGCAGCCTACCAAGAACA 
               
               
                   
                   
                 ACTGGACCGACCGGTGGTACCTCACCCTTACCGAGTCGGCGACACAGTGTGGGTCC 
               
               
                   
                   
                 GCCGACACCAGACTAAGAACCTAGAACCTCGCTGGAAAGGACCTTACACAGTCCTG 
               
               
                   
                   
                 CTGACCACCCCCACCGCCCTCAAAGTAGACGGCATCGCAGCTTGGATACACGCCGC 
               
               
                   
                   
                 CCACGTGAAGGCTGCCGACCCCGGGGGTGGACCATGACTCGAGCCATGGATTGGA 
               
               
                   
                   
                 TCTGGCGCATCCTGTTTCTCGTGGGAGCTGCCACAGGCGCCCATTCTCAGGTTCAG 
               
               
                   
                   
                 CTGCAACAGTGGGGAGCCGGACTGCTGAAGCCTAGCGAAACACTGAGCCTGACCT 
               
               
                   
                   
                 GTGCCGTGTACGGCGGCAGCTTTAGCGGCTACTACTGGTCCTGGATCAGACAGCCT 
               
               
                   
                   
                 CCTGGCAAAGGCCTGGAATGGATCGGCGAGATCAATCACAGCGGCAGCACCAACTA 
               
               
                   
                   
                 CAACCCCAGCCTGAAGTCCAGAGTGACCATCAGCGTGGACACCAGCAAGAACCAGT 
               
               
                   
                   
                 TCTCCCTGAAGCTGAGCAGCGTGACCACAGCCGATACCGCCGTGTACTACTGTGCC 
               
               
                   
                   
                 CGGATGGGCATCAATAGCGGCGGCTACCTGTACGGCATGGATGTGTGGGGACAGG 
               
               
                   
                   
                 GCACCACCGTGACAGTTTCTAGCGGAGGCGGAGGTTCTGGTGGCGGAGGAAGTGG 
               
               
                   
                   
                 CGGCGGAGGATCTCAGACAGTGGTCACACAAGAGCCCAGCTTCTCCGTGTCTCCTG 
               
               
                   
                   
                 GCGGAACAGTGACCCTGACATGTGGCCTTAGCAGCGGCTCTGTGTCCACCAGCTAC 
               
               
                   
                   
                 TACCCTAGCTGGTATCAGCAGATCCCCGGACAGGCCCCTCGGACACTGATCTACAC 
               
               
                   
                   
                 CACCAACATCAGATCCAGCGGCGTGCCCGATAGATTCGGCGGATCTATCCTGGGCA 
               
               
                   
                   
                 ACAAGGCCGCACTGACAATCACAGGTGCCCAGGCCGAGGACGAGTCCGACTACTAC 
               
               
                   
                   
                 TGCATGCTGTACATGGGCAGCGGCATCTGGGTTTTCGGCGGAGGCACAAAGCTGAC 
               
               
                   
                   
                 CGTTCTGGGATCCGAACCAAAGAGTTGCGACAAAACACACACCTGCCCTACGCGTTT 
               
               
                   
                   
                 TTGGGTGCTCGTGGTGGTGGGTGGCGTGCTCGCTTGCTACTCACTTCTGGTGACCG 
               
               
                   
                   
                 TAGCGTTTATCATTTTTTGGGTCAGGAGCAAGCGATCCCGCCTATTGCACAGCGACT 
               
               
                   
                   
                 ACATGAACATGACCCCCCGGCGCCCCGGGCCAACCCGGAAGCACTACCAGCCATAT 
               
               
                   
                   
                 GCGCCTCCCCGCGATTTCGCAGCGTATCGGTCCCGGGTCAAATTTTCACGGTCCGC 
               
               
                   
                   
                 TGACGCCCCGGCCTATCAACAGGGCCAGAATCAGCTGTATAATGAATTAAACCTCGG 
               
               
                   
                   
                 TAGACGCGAGGAGTACGACGTCCTCGACAAGAGAAGGGGGCGCGACCCAGAGATG 
               
               
                   
                   
                 GGAGGCAAACCGCAGCGCAGGAAGAATCCACAGGAGGGCCTGTACAACGAATTACA 
               
               
                   
                   
                 GAAGGACAAGATGGCAGAGGCCTACAGCGAGATAGGAATGAAGGGTGAAAGGCGT 
               
               
                   
                   
                 CGTGGAAAGGGCCACGATGGGCTTTACCAGGGCCTAAGTACTGCCACAAAAGATAC 
               
               
                   
                   
                 GTATGACGCGCTGCATATGCAAGCCCTCCCCCCCAGGTAAGCATGCAACCTCGATC 
               
               
                   
                   
                 CGGATTAGTCCAATTTGTTAAAGACAGGATATCAGTGGTCCAGGCTCTAGTTTTGACT 
               
               
                   
                   
                 CAACAATATCACCAGCTGAAGCCTATAGAGTACGAGCCATAGATAAAATAAAAGATTT 
               
               
                   
                   
                 TATTTAGTCTCCAGAAAAAGGGGGGAATGAAAGACCCCACCTGTAGGTTTGGCAAGC 
               
               
                   
                   
                 TAGCTTAAGTAACGCCATTTTGCAAGGCATGGAAAAATACATAACTGAGAATAGAGAA 
               
               
                   
                   
                 GTTCAGATCAAGGTCAGGAACAGATGGAACAGCTGAATATGGGCCAAACAGGATAT 
               
               
                   
                   
                 CTGTGGTAAGCAGTTCCTGCCCCGGCTCAGGGCCAAGAACAGATGGAACAGCTGAA 
               
               
                   
                   
                 TATGGGCCAAACAGGATATCTGTGGTAAGCAGTTCCTGCCCCGGCTCAGGGCCAAG 
               
               
                   
                   
                 AACAGATGGTCCCCAGATGCGGTCCAGCCCTCAGCAGTTTCTAGAGAACCATCAGA 
               
               
                   
                   
                 TGTTTCCAGGGTGCCCCAAGGACCTGAAATGACCCTGTGCCTTATTTGAACTAACCA 
               
               
                   
                   
                 ATCAGTTCGCTTCTCGCTTCTGTTCGCGCGCTTC 
               
               
                   
               
               
                 119 
                 HER2(F1)- 
                 AAGTTCAGATCAAGGTCAGGAACAGATGGAACAGCTGAATATGGGCCAAACAGGAT 
               
               
                   
                 CD28TM, ICD- 
                 ATCTGTGGTAAGCAGTTCCTGCCCCGGCTCAGGGCCAAGAACAGATGGAACAGCTG 
               
               
                   
                 CD3Z CAR 
                 AATATGGGCCAAACAGGATATCTGTGGTAAGCAGTTCCTGCCCCGGCTCAGGGCCA 
               
               
                   
                   
                 AGAACAGATGGTCCCCAGATGCGGTCCAGCCCTCAGCAGTTTCTAGAGAACCATCA 
               
               
                   
                   
                 GATGTTTCCAGGGTGCCCCAAGGACCTGAAATGACCCTGTGCCTTATTTGAACTAAC 
               
               
                   
                   
                 CAATCAGTTCGCTTCTCGCTTCTGTTCGCGCGCTTCTGCTCCCCGAGCTCAATAAAA 
               
               
                   
                   
                 GAGCCCACAACCCCTCACTCGGCGCGCCAGTCCTCCGATTGACTGAGTCGCCCGG 
               
               
                   
                   
                 GTACCCGTGTATCCAATAAACCCTCTTGCAGTTGCATCCGACTTGTGGTCTCGCTGT 
               
               
                   
                   
                 TCCTTGGGAGGGTCTCCTCTGAGTGATTGACTACCCGTCAGCGGGGGTCTTTCATTT 
               
               
                   
                   
                 GGGGGCTCGTCCGGGATCGGGAGACCCCTGCCCAGGGACCACCGACCCACCACC 
               
               
                   
                   
                 GGGAGGTAAGCTGGCCAGCAACTTATCTGTGTCTGTCCGATTGTCTAGTGTCTATGA 
               
               
                   
                   
                 CTGATTTTATGCGCCTGCGTCGGTACTAGTTAGCTAACTAGCTCTGTATCTGGCGGA 
               
               
                   
                   
                 CCCGTGGTGGAACTGACGAGTTCGGAACACCCGGCCGCAACCCTGGGAGACGTCC 
               
               
                   
                   
                 CAGGGACTTCGGGGGCCGTTTTTGTGGCCCGACCTGAGTCCTAAAATCCCGATCGT 
               
               
                   
                   
                 TTAGGACTCTTTGGTGCACCCCCCTTAGAGGAGGGATATGTGGTTCTGGTAGGAGA 
               
               
                   
                   
                 CGAGAACCTAAAACAGTTCCCGCCTCCGTCTGAATTTTTGCTTTCGGTTTGGGACCG 
               
               
                   
                   
                 AAGCCGCGCCGCGCGTCTTGTCTGCTGCAGCATCGTTCTGTGTTGTCTCTGTCTGA 
               
               
                   
                   
                 CTGTGTTTCTGTATTTGTCTGAAAATATGGGCCCGGGCTAGCCTGTTACCACTCCCT 
               
               
                   
                   
                 TAAGTTTGACCTTAGGTCACTGGAAAGATGTCGAGCGGATCGCTCACAACCAGTCG 
               
               
                   
                   
                 GTAGATGTCAAGAAGAGACGTTGGGTTACCTTCTGCTCTGCAGAATGGCCAACCTTT 
               
               
                   
                   
                 AACGTCGGATGGCCGCGAGACGGCACCTTTAACCGAGACCTCATCACCCAGGTTAA 
               
               
                   
                   
                 GATCAAGGTCTTTTCACCTGGCCCGCATGGACACCCAGACCAGGTCCCCTACATCG 
               
               
                   
                   
                 TGACCTGGGAAGCCTTGGCTTTTGACCCCCCTCCCTGGGTCAAGCCCTTTGTACAC 
               
               
                   
                   
                 CCTAAGCCTCCGCCTCCTCTTCCTCCATCCGCCCCGTCTCTCCCCCTTGAACCTCCT 
               
               
                   
                   
                 CGTTCGACCCCGCCTCGATCCTCCCTTTATCCAGCCCTCACTCCTTCTCTAGGCGCC 
               
               
                   
                   
                 CCCATATGGCCATATGAGATCTTATATGGGGCACCCCCGCCCCTTGTAAACTTCCCT 
               
               
                   
                   
                 GACCCTGACATGACAAGAGTTACTAACAGCCCCTCTCTCCAAGCTCACTTACAGGCT 
               
               
                   
                   
                 CTCTACTTAGTCCAGCACGAAGTCTGGAGACCTCTGGCGGCAGCCTACCAAGAACA 
               
               
                   
                   
                 ACTGGACCGACCGGTGGTACCTCACCCTTACCGAGTCGGCGACACAGTGTGGGTCC 
               
               
                   
                   
                 GCCGACACCAGACTAAGAACCTAGAACCTCGCTGGAAAGGACCTTACACAGTCCTG 
               
               
                   
                   
                 CTGACCACCCCCACCGCCCTCAAAGTAGACGGCATCGCAGCTTGGATACACGCCGC 
               
               
                   
                   
                 CCACGTGAAGGCTGCCGACCCCGGGGGTGGACCATGACTCGAGCCATGGATTGGA 
               
               
                   
                   
                 TCTGGCGCATCCTGTTTCTCGTGGGAGCTGCCACAGGCGCCCATTCTCAGGTTCAG 
               
               
                   
                   
                 CTGGTGGAATCTGGCCCTGGCCTGGTTAAGCCTAGCGGCACACTGTCTCTGACCTG 
               
               
                   
                   
                 TGCTGTGTCTGGCGGCAGCATCAGCAGCAGCAATTGGTGGTCTTGGGTCCGACAGC 
               
               
                   
                   
                 CTCCTGGCAAAGGCCTGGAATGGATCGGCGAGATCTACCACAGCGGCAGCACCAAC 
               
               
                   
                   
                 TACAACCCCAGCCTGAAGTCCAGAGTGACCATCAGCGTGGACACCAGCAAGAACCA 
               
               
                   
                   
                 GTTCTCCCTGAAGCTGAGCAGCGTGACAGCCGCCGATACAGCCGTGTACTACTGTG 
               
               
                   
                   
                 CCAGAATGGGAGCCAATAGCGGCGGCTACCTGTACGGCATGGATGTGTGGGGACA 
               
               
                   
                   
                 GGGCACCACCGTGACAGTTTCTAGCGGAGGCGGAGGTTCTGGTGGCGGAGGAAGT 
               
               
                   
                   
                 GGCGGCGGAGGATCTCAGACAGTGGTCACACAAGAGCCCAGCTTCTCCGTGTCTCC 
               
               
                   
                   
                 TGGCGGAACAGTGACCCTGACATGTGGCCTTAGCAGCGGCTCTGTGTCTACCAGCT 
               
               
                   
                   
                 ACTACCCCTCCTGGTATCAGCAGACCCCTGGACAGGCTCCCCGGACACTGATCTAC 
               
               
                   
                   
                 TCCACCAACACCAGATCCAGCGGCGTGCCCGATAGATTCTCCGGCTCTATCCTGGG 
               
               
                   
                   
                 CAACAAGGCCGCACTGACAATCACAGGCGCTCAGGCCGATGACGAGAGCGACTACT 
               
               
                   
                   
                 ACTGCGTGCTGTACATGGGCAGCGGCATCTGGGTTTTCGGCGGAGGCACAAAGCTG 
               
               
                   
                   
                 ACCGTTCTGGGATCCGAACCAAAGAGTTGCGACAAAACACACACCTGCCCTACGCG 
               
               
                   
                   
                 TTTTTGGGTGCTCGTGGTGGTGGGTGGCGTGCTCGCTTGCTACTCACTTCTGGTGA 
               
               
                   
                   
                 CCGTAGCGTTTATCATTTTTTGGGTCAGGAGCAAGCGATCCCGCCTATTGCACAGCG 
               
               
                   
                   
                 ACTACATGAACATGACCCCCCGGCGCCCCGGGCCAACCCGGAAGCACTACCAGCC 
               
               
                   
                   
                 ATATGCGCCTCCCCGCGATTTCGCAGCGTATCGGTCCCGGGTCAAATTTTCACGGT 
               
               
                   
                   
                 CCGCTGACGCCCCGGCCTATCAACAGGGCCAGAATCAGCTGTATAATGAATTAAAC 
               
               
                   
                   
                 CTCGGTAGACGCGAGGAGTACGACGTCCTCGACAAGAGAAGGGGGCGCGACCCAG 
               
               
                   
                   
                 AGATGGGAGGCAAACCGCAGCGCAGGAAGAATCCACAGGAGGGCCTGTACAACGA 
               
               
                   
                   
                 ATTACAGAAGGACAAGATGGCAGAGGCCTACAGCGAGATAGGAATGAAGGGTGAAA 
               
               
                   
                   
                 GGCGTCGTGGAAAGGGCCACGATGGGCTTTACCAGGGCCTAAGTACTGCCACAAAA 
               
               
                   
                   
                 GATACGTATGACGCGCTGCATATGCAAGCCCTCCCCCCCAGGTAAGCATGCAACCT 
               
               
                   
                   
                 CGATCCGGATTAGTCCAATTTGTTAAAGACAGGATATCAGTGGTCCAGGCTCTAGTT 
               
               
                   
                   
                 TTGACTCAACAATATCACCAGCTGAAGCCTATAGAGTACGAGCCATAGATAAAATAAA 
               
               
                   
                   
                 AGATTTTATTTAGTCTCCAGAAAAAGGGGGGAATGAAAGACCCCACCTGTAGGTTTG 
               
               
                   
                   
                 GCAAGCTAGCTTAAGTAACGCCATTTTGCAAGGCATGGAAAAATACATAACTGAGAA 
               
               
                   
                   
                 TAGAGAAGTTCAGATCAAGGTCAGGAACAGATGGAACAGCTGAATATGGGCCAAAC 
               
               
                   
                   
                 AGGATATCTGTGGTAAGCAGTTCCTGCCCCGGCTCAGGGCCAAGAACAGATGGAAC 
               
               
                   
                   
                 AGCTGAATATGGGCCAAACAGGATATCTGTGGTAAGCAGTTCCTGCCCCGGCTCAG 
               
               
                   
                   
                 GGCCAAGAACAGATGGTCCCCAGATGCGGTCCAGCCCTCAGCAGTTTCTAGAGAAC 
               
               
                   
                   
                 CATCAGATGTTTCCAGGGTGCCCCAAGGACCTGAAATGACCCTGTGCCTTATTTGAA 
               
               
                   
                   
                 CTAACCAATCAGTTCGCTTCTCGCTTCTGTTCGCGCGCTTC 
               
               
                   
               
               
                 120 
                 HDAdIL- 
                 AAACATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGGGGGT 
               
               
                   
                 12_TK_PD-L1 
                 GGAGTTTGTGACGTGGCGCGGGGCGTGGGAACGGGGCGGGTGACGTAGTAGTGT 
               
               
                   
                   
                 GGCGGAAGTGTGATGTTGCAAGTGTGGCGGAACACATGTAAGCGACGGATGTGGCA 
               
               
                   
                   
                 AAAGTGACGTTTTTGGTGTGCGCCGGTGTACACAGGAAGTGACAATTTTCGCGCGG 
               
               
                   
                   
                 TTTTAGGCGGATGTTGTAGTAAATTTGGGCGTAACCGAGTAAGATTTGGCCATTTTC 
               
               
                   
                   
                 GCGGGAAAACTGAATAAGAGGAAGTGAAATCTGAATAATTTTGTGTTACTCATAGCG 
               
               
                   
                   
                 CGTAATATTTGTCTAGGGCCGCGGGGACTTTGACCGTTTACGTGGAGACTCGCCCA 
               
               
                   
                   
                 GGTGTTTTTCTCAGGTGTTTTCCGCGTTCCGGGTCAAAGTTGGCGTTTTGATATCAA 
               
               
                   
                   
                 GCTTATCGATACCGTAAACAAGTCTTTAATTCAAGCAAGACTTTAACAAGTTAAAAGG 
               
               
                   
                   
                 AGCTTATGGGTAGGAAGTAGTGTTATGATGTATGGGCATAAAGGGTTTTAATGGGAT 
               
               
                   
                   
                 AGTGAAAATGTCTATAATAATACTTAAATGGCTGCCCAATCACCTACAGGATTGATGT 
               
               
                   
                   
                 AAACATGGAAAAGGTCAAAAACTTGGGTCACTAAAATAGATGATTAATGGAGAGGAT 
               
               
                   
                   
                 GAGGTTGATAGTTAAATGTAGATAAGTGGTCTTATTCTCAATAAAAATGTGAACATAA 
               
               
                   
                   
                 GGCGAGTTTCTACAAAGATGGACAGGACTCATTCATGAAACAGCAAAAACTGGACAT 
               
               
                   
                   
                 TTGTTCTAATCTTTGAAGAGTATGAAAAATTCCTATTTTAAAGGTAAAACAGTAACTCA 
               
               
                   
                   
                 CAGGAAATACCAACCCAACATAAAATCAGAAACAATAGTCTAAAGTAATAAAAATCAA 
               
               
                   
                   
                 ACGTTTGCACGATCAAATTATGAATGAAATTCACTACTAAAATTCACACTGATTTTGTT 
               
               
                   
                   
                 TCATCCACAGTGTCAATGTTGTGATGCATTTCAATTGTGTGACACAGGCAGACTGTG 
               
               
                   
                   
                 GATCAAAAGTGGTTTCTGGTGCGACTTACTCTCTTGAGTATACCTGCAGTCCCCTTTC 
               
               
                   
                   
                 TTAAGTGTGTTAAAAAAAAAGGGGGATTTCTTCAATTCGCCAATACTCTAGCTCTCCA 
               
               
                   
                   
                 TGTGCTTTCTAGGAAACAAGTGTTAACCCACCTTATTTGTCAAACCTAGCTCCAAAGG 
               
               
                   
                   
                 ACTTTTGACTCCCCACAAACCGATGTAGCTCAAGAGAGGGTATCTGTCACCAGTATG 
               
               
                   
                   
                 TATAGTGAAAAAAGTATCCCAAGTCCCAACAGCAATTCCTAAAAGGAGTTTATTTAAA 
               
               
                   
                   
                 AAACCACACACACCTGTAAAATAAGTATATATCCTCCAAGGTGACTAGTTTTAAAAAA 
               
               
                   
                   
                 ACAGTATTGGCTTTGATGTAAAGTACTAGTGAATATGTTAGAAAAATCTCACTGTAAC 
               
               
                   
                   
                 CAAGTGAAATGAAAGCAAGTATGGTTTGCAGAGATTCAAAGAAAATATAAGAAAACCT 
               
               
                   
                   
                 ACTGTTGCCACTAAAAAGAATCATATATTAAATATACTCACACAATAGCTCTTCAGTCT 
               
               
                   
                   
                 GATAAAATCTACAGTCATAGGAATGGATCTATCACTATTTCTATTCAGTGCTTTGATGT 
               
               
                   
                   
                 AATCCAGCAGGTCAGCAAAGAATTTATAGCCCCCCTTGAGCACACAGAGGGCTACAA 
               
               
                   
                   
                 TGTGATGGCCTCCCATCTCCTTCATCACATCTCGAGCAAGACGTTCAGTCCTACAGA 
               
               
                   
                   
                 AATAAAATCAGGAATTTAATAGAAAGTTTCATACATTAAACTTTATAACAAACACCTCT 
               
               
                   
                   
                 TAGTCATTAAACTTCCACACCAACCTGGGCAATATAGTGAGACCCCATGCCTGCAAA 
               
               
                   
                   
                 AAAAAAAAAATTAGCCAGGCATGGTAGCATGTACCTGTAGTCCCAGCTACTTGAGAG 
               
               
                   
                   
                 GTGAGGTGGGAAAATCACTTTAGTGCAGGATGTTGAGGCTGGAGTGAACTGTGATT 
               
               
                   
                   
                 GTGCCACTGCACTCCAGCCTGGACAATAGAGCAAGACCTTGTCTCAAAAAAATGCAT 
               
               
                   
                   
                 TAAAAATTTTTTTTAAATCTTCCACGTATCACATCCTTTGCCCTCATGTTTCATAAGGT 
               
               
                   
                   
                 AAAAAATTTGATACCTTCAAAAAAACCAAGCATACCACTATCATAATTTTTTTTAAATG 
               
               
                   
                   
                 CAAATAAAAACAAGATACCATTTTCACCTATCAGACTGGCAGGTTCTGATTAAATGAA 
               
               
                   
                   
                 ATTTTCTGGATAATATACAATATTAAGAGAGACTGTAGAAACTGGGCCAGTGGCTCAT 
               
               
                   
                   
                 GCCTGTAATCCCAGCACTTTGGGAGGCTGGGTAACATGGCGAACCCTGTTTCTACAA 
               
               
                   
                   
                 AATAAAAATATTAGCTGGGAGTGGTGGCGCACACCTATAGTCCCAGCTACTCAGGAG 
               
               
                   
                   
                 GCTGAGGTGGAAGGATCGCTTGAACCCAGGAGGTTGAGACTGCAGTGAACTGTGAT 
               
               
                   
                   
                 CATTCTGCTGCACTGCACCCCAGCCTGGGCAACAGAGACCTTGTCTCAAAAAAAAAA 
               
               
                   
                   
                 AAAAAAGAGACAAATTGTGAAGAGAAAGGTACTCTCATATAACATCAGGAGTATAAAA 
               
               
                   
                   
                 TGATTCAACTTCTTAGAGGAAAATTTGGCAATACCAAAATATTCAATAAACTCTTTCCC 
               
               
                   
                   
                 CTTGACCCAGAAATTCCACTTGAATAAAGCTGAACAAGTACCAAACATGTAAAAGAAT 
               
               
                   
                   
                 GTTTCTTCTAGTACAGTCGGTAAGAACAAAATAGTGTCTATCAATAGTGGACTGGTTA 
               
               
                   
                   
                 AATCAGTTATGGTATCTCCATAAGACAGAATGCTATGCAACCTTTAAAATATATTAGAT 
               
               
                   
                   
                 AGCTCTAGACACACTAATATTAAAAGTGTCCAATAACATTTAAAACTATACTCATACGT 
               
               
                   
                   
                 TAAAATATAAATGTATATATGTACTTTTGCATATAGTATACATGCATAGGCCAGTGCTT 
               
               
                   
                   
                 GAGAAGAAATGTGTACAGAAGGCTGAAAGGAGAGAACTTTAGTCTTCTTGTTTATGG 
               
               
                   
                   
                 CCTCCATAGTTAGAATATTTTATAACACAAATATTTTGATATTATAATTTTAAAATAAAA 
               
               
                   
                   
                 ACACAGAATAGCCAGACATACAATGCAAGCATTCAATACCAGGTAAGGTTTTTCACT 
               
               
                   
                   
                 GTAATTGACTTAACAGAAAATTTTCAAGCTAGATGTGCATAATAATAAAAATCTGACCT 
               
               
                   
                   
                 TGCCTTCATGTGATTCAGCCCCAGTCCATTACCCTGTTTAGGACTGAGAAATGCAAG 
               
               
                   
                   
                 ACTCTGGCTAGAGTTCCTTCTTCCATCTCCCTTCAATGTTTACTTTGTTCTGGTCCCT 
               
               
                   
                   
                 ACAGAGTCCCACTATACCACAACTGATACTAAGTAATTAGTAAGGCCCTCCTCTTTTA 
               
               
                   
                   
                 TTTTTAATAAAGAAGATTTTAGAAAGCATCAGTTATTTAATAAGTTGGCCTAGTTTATG 
               
               
                   
                   
                 TTCAAATAGCAAGTACTCAGAACAGCTGCTGATGTTTGAAATTAACACAAGAAAAAGT 
               
               
                   
                   
                 AAAAAACCTCATTTTAAGATCTTACTTACCTGTCCATAATTAGTCCATGAGGAATAAAC 
               
               
                   
                   
                 ACCCTTTCCAAATCCTCAGCATAATGATTAGGTATGCAAAATAAATCAAGGTCATAAC 
               
               
                   
                   
                 CTGGTTCATCATCACTAATCTGAAAAAGAAATATAGCTGTTTCAATGAGAGCATTACA 
               
               
                   
                   
                 GGATACAAACATTTGATTGGATTAAGATGTTAAAAAATAACCTTAGTCTATCAGAGAA 
               
               
                   
                   
                 ATTTAGGTGTAAGATGATATTAGTAACTGTTAACTTTGTAGGTATGATAATGAATTATG 
               
               
                   
                   
                 TAAGAAAACAACAGGCCGGGCGGGTTGGTTCACACGTGTAATCCCAGCACTTTGGG 
               
               
                   
                   
                 AGGCTGAGGCAGGCAGACTGCCTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAAC 
               
               
                   
                   
                 ACGGTGAAATCCCGTCTCTACTAAAAATACAAAAAAATTAGCCGGGTGTGGTGACAC 
               
               
                   
                   
                 ATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGG 
               
               
                   
                   
                 GAGGTGAAGGTTGCAGTGAGCCAAGATGGCACCACTTCACTCCAGCCTGGGAAACA 
               
               
                   
                   
                 GAGCAAGACTCTGTCTCTGAGCTGAGATGGCACCACTTCACTCCAGCCTGGGAAAC 
               
               
                   
                   
                 AGAGCAAGACTCTGTCTCAAAAAAAACAAAACACACAAACAAAAAAACAGGCTGGGC 
               
               
                   
                   
                 GCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCA 
               
               
                   
                   
                 CCTGAGGTCAGGAGTTCCAGACCAGCCTTGTCAACATGGTGAAACCTCCCCCCGCC 
               
               
                   
                   
                 GTCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGCAGGAGCCTGTAATCCCA 
               
               
                   
                   
                 GCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGTACCCAGAAGGCAGAGGTTGCA 
               
               
                   
                   
                 CTGAGCTGAGATGGCACCATTGCACTCCAGCCTGGGGGACAAGAGCGAGATTTCGT 
               
               
                   
                   
                 CTTTAAAAAACAAAAACAAAACAAAAAACCATGTAACTATATGTCTTAGTCATCTTAGT 
               
               
                   
                   
                 CAAGAATGTAGAAGTAAAGTGATAAGATATGGAATTTCCTTTAGGTCACAAAGAGAAA 
               
               
                   
                   
                 AAGAAAAATTTTAAAGAGCTAAGACAAACGCAGCAAAATCTTTATATTTAATAATATTC 
               
               
                   
                   
                 TAAACATGGGTGATGAACATACGGGTATTCATTATACTATTCTCTCCACTTTTGAGTA 
               
               
                   
                   
                 TGTTTGAAAATTTAGTAAAACAAGTTTTAACACACTGTAGTCTAACAAGATAAAATATC 
               
               
                   
                   
                 ACACTGAACAGGAAAAACTGGCATGGTGTGGTGGCTCACACTTGTAATCCCAGTGCT 
               
               
                   
                   
                 TTGGGAGGCTGAGACAGGAGAGTTGCTTGAGGCCAGGAGTTCAAGACCGACATGG 
               
               
                   
                   
                 GGAATGTAGCAAGACCCCGTCCCTACAAAAAACTTTGTAAAAATTTGCCAGGTATGG 
               
               
                   
                   
                 TGGTGCATACCTGTAGTCCCAGCTACTCGGGAGGCGGAGGCAGAAGGAATCACTTG 
               
               
                   
                   
                 AGCCCAGGAGTTTGAGGCTGCAGTGAGCTACGATCATACCACAGCACTCCAGCGTG 
               
               
                   
                   
                 GACAACAGAGTAAGACCCTATCTCAAAAACAAAACAAAACAAAACAAACAAAAAAAAC 
               
               
                   
                   
                 CACAAGAAAAACTGCTGGCTGATGCAGCGGCTCATGCCTGTAATCCCAGTATTTTGG 
               
               
                   
                   
                 GAGGCCCAGGTGGGCGTATCACCTGAGGTCAGGAGTTAGAGACCAGCCTGGCCAA 
               
               
                   
                   
                 CATGGTGAAACCCCATCTCTACTAAAAATACAAAATTAGCCAGGCATGTGGCACGCG 
               
               
                   
                   
                 CCTGTAGTCCCAGTTACTGGGAGGCTGAAGCAGGAGGATCACCTGAGCCCGGGAG 
               
               
                   
                   
                 GTGGAGGTTGCAGTGAGCCGAGATCACACCACTGCACTCCAGCCTGGGTGACACAG 
               
               
                   
                   
                 CAATACCCTACCTCAAAATAAAAAAGAAAAAGAAAAGAAAAGTTGCTGTCCCCGCTAC 
               
               
                   
                   
                 CCCAATCCCAAATCCAAACAGCCTCTCTCATCTCACAGTAAGGGGGAAAAATCACCC 
               
               
                   
                   
                 AAAAAAGCTAAGTGATCTTTTGAAAACCCAAACTCTTAGAAGTCTAAGATTATTATAGT 
               
               
                   
                   
                 CAACTCATGAAGTGTCATCATAAAAGATACTCTAATATTATTTAAGTAGAACCACATAT 
               
               
                   
                   
                 TGGTTGTCTTGGTATGTCTAGCCCCTGGCATACAAAATATTTAATAACACTGATATGG 
               
               
                   
                   
                 TACCTGTGATGTGAAAATGTACTATGAGTACAGCTTTATAAATACTATATATGTACCTA 
               
               
                   
                   
                 TATACAGAAAAAAATACAACAAAATCATAAAAGCACTTATCTTTGAAAGAGGAGTTAC 
               
               
                   
                   
                 AGCAATTTTATTTAGTTCTTTATTGCTTTGCTATATATTCTAAATTTTTTTCAATGAATAT 
               
               
                   
                   
                 ATATCACTTTTAAAAAAATTCAATGGTCTTTCTTATAAATTATCTTTGGCAGCATGCGT 
               
               
                   
                   
                 TTTTATATATACATATAAAATGTATGGGAAATTTTTAAAGGATACATTAAATTAAAGCAA 
               
               
                   
                   
                 AATATACAAACAAAAAATCAGAATACAAAAAGATAAAAAGATTGGGAAGGGAGGGAG 
               
               
                   
                   
                 GGAGTAAGGAGGAAGGGTGGGTGGGTATAGAGAAATATACCAAATAATGGTAAGAA 
               
               
                   
                   
                 GTGGGGTCTTGACACTTTCTACACTTTTTTTAAATAAAAAAAATTTTTTTCTCTCTCTTT 
               
               
                   
                   
                 TTTTTTTTTAGAGACGAAGTCTCGCTATGTTGCCCAGGCTGGTCTTGAACTCCTGGG 
               
               
                   
                   
                 ATCAAGAGATCCTCCTGCCTCAGCCTCCCAAGGTGCTTGGATTACAGGTGTGAGCC 
               
               
                   
                   
                 ACCACGCCTGGTCACTTTCTACACTTTAATATATATATTTTTTCATTTTCAATGTCATTT 
               
               
                   
                   
                 TTATTAGTTAATTTATAATACCCATTCACCATTATATTCAAAGTCTATTTGAAGAAATAA 
               
               
                   
                   
                 ACCAGAAAGAATGAAATACTCTAGCTCACATGCTATTCAATACTAAATTACCTTTCAAA 
               
               
                   
                   
                 TCACATTCAAGAAGCTGATGATTTAAGCTTTGGCGGTTTCCAATAAATATTGGTCAAA 
               
               
                   
                   
                 CCATAATTAAATCTCAATATATCAGTTAGTACCTATTGAGCATCTCCTTTTACAACCTA 
               
               
                   
                   
                 AGCATTGTATTAGGTGCTTAAATACAAGCAGCTTGACTTTTAATACATTTAAAAATACA 
               
               
                   
                   
                 TATTTAAGACTTAAAATCTTATTTATGGAATTCAGTTATATTTTGAGGTTTCCAGTGCT 
               
               
                   
                   
                 GAGAAATTTGAGGTTTGTGCTGTCTTTCAGTCCCCAAAGCTCAGTTCTGAGTTCTCA 
               
               
                   
                   
                 GACTTTGGTGGAACTTCATGTATTGTCAGGTTGGCCCGTAATACCTGTGGGACAACT 
               
               
                   
                   
                 TCAGCCCCTGTGCACATGGCCAGGAGGCTGGTTGCAAACATTTTCAGGTAGGTGGA 
               
               
                   
                   
                 CCAGGACATGCCCCTGGTCATGGCCAGGTGGAGGCATAGTGCTATACAGCAGGCA 
               
               
                   
                   
                 GAAGTCAATATTGATTTGTTTTTAAAGAAACATGTACTACTTTCATAAGCAGAAAAAAT 
               
               
                   
                   
                 TTCTATTCTTGGGGGAAAAGATTATGCCAGATCCTCTAGGATTAAATGCTGATGCATC 
               
               
                   
                   
                 TGCTAAACCTTCACATATCAGAACATATTTACTATAGAAAGAATGAAAATGGGACATT 
               
               
                   
                   
                 TGTGTGTCACCTATGTGAACATTCCAAAAATATTTTACAACAACTAAGTATTTTATAAA 
               
               
                   
                   
                 TTTTATGAACTGAAATTTAGTTCAAGTTCTAGGAAAATACAAACCTTGCTAGATATTAT 
               
               
                   
                   
                 AAAAATGATACAATATATATTCATTTCAGGCTCATCAGAATATATCTGTTATCACTTGA 
               
               
                   
                   
                 CAAGAATGAAAATGCACCATTTTGTAGTGCTTTAAAATCAGGAAGATCCAGAGTACTA 
               
               
                   
                   
                 AAAATGACTTCTTCCTTGAAGCTTACTCACCAACTTCCTCCCAGTTACTCACTGCTTC 
               
               
                   
                   
                 TGCCACAAGCATAAACTAGGACCCAGCCAGAACTCCCTTGAAATATACACTTGCAAC 
               
               
                   
                   
                 GATTACTGCATCTATCAAAATGGTTCAGTGCCTGGCTACAGGTTCTGCAGATCGACT 
               
               
                   
                   
                 AAGAATTTGAAAAGTCTTGTTTATTTCAAAGGAAGCCCATGTGAATTCTGCCCAGAGT 
               
               
                   
                   
                 TCATCCCAGATATGCAGTCTAAGAATACAGACAGATCAGCAGAGATGTATTCTAAAAC 
               
               
                   
                   
                 AGGAATTCTGGCAATATAACAAATTGATTTCCAATCAAAACAGATTTACATACCATACT 
               
               
                   
                   
                 TATGTCAAGAAGTTGTTTTGTTTTATTGCATCCTAGATTTTATTTTTTTGATTTATGGTT 
               
               
                   
                   
                 TACTTTAAGCATAAAAAATTTGTCAATACAACTCTTCCCAAAAGGCATAAACAAAAATT 
               
               
                   
                   
                 CATAAAACTTGCATCACTTGAGATACTTCAGGTATGAATTCACAACTTTGTTACAACTT 
               
               
                   
                   
                 ACTATATATATGCACACATATATATATATTTGGGTATATTGGGGGGGTTCTAATTTAAG 
               
               
                   
                   
                 AAATGCATAATTGGCTATAGACAGACAGTTGTCTGGAATGAAAATCAATACTTTTGCT 
               
               
                   
                   
                 ATAATCGATTACTGAAATAATTTTACTTTCCAGTAAAACTGGCATTATAATTTTTTTTAA 
               
               
                   
                   
                 TTTTTAAAACTTCATAATTTTTTGCCAGACTGACCCATGTAAACATACAAATTACTAAT 
               
               
                   
                   
                 AATTATGCACGTCACATCTGTAATAATGGCCTTCATGTAAACATTTTTGTGGTTTACAC 
               
               
                   
                   
                 ATAAAATCTCTAATTACAAAGCTATATTATCTAAAATTACAGTAAGCAAGAAAATTAAT 
               
               
                   
                   
                 CCAAGCTAAGACAATACTTGCAACATCAATTCATCATCTGTGACAAGGACTGCTTAAG 
               
               
                   
                   
                 TCTCTTTGTGGTTAAAAAGGAAAAAAAAAAAAAAGACATGTTGGCCAGATGCGGTGG 
               
               
                   
                   
                 CTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCGGATCACCCCTGGC 
               
               
                   
                   
                 CTGCCCAACATGGTGAAACCCCGTCTCTACTAAAAACACAAAAATTAGCTGGGCGTG 
               
               
                   
                   
                 GTGGCGGGCGCCTGTAATTCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTA 
               
               
                   
                   
                 GAACCCAGGAGGCAGAGATTGCAGTGAGCTGAGATTGCACCATTGCACTACAGTCT 
               
               
                   
                   
                 GGGCAACAAAAGTGAAACTCCATCTTAAAAAAAAAAAGACAATGTTCGTGGGTCCAA 
               
               
                   
                   
                 ACAAGACTTAATGGAAGTGAGTCTAAAAATGAGCTATGTGGGCCAGGCGTAGTGGCT 
               
               
                   
                   
                 CCCACCTGTAATCCCAGCACTTTGGGAGGCCGAAGCAGGCAGATCATGAGGTCAGG 
               
               
                   
                   
                 AGATGGAGACCATCCTGGCCAACACGGTGAAATCCTGTCTCTACAAAAATTAGCTGG 
               
               
                   
                   
                 GCGTGGTGGTGCCTGCCTGTAATCCCAGCTACTCAGAAGGCTCAGGCAGGAGAATC 
               
               
                   
                   
                 GCTTGAACCAGGGAGTCGGTGGCTAGAGTGAGCCGAGATTTGCATCACTGCACTCC 
               
               
                   
                   
                 TGCCTGGTGACAGAGCAAGACTCCATCTCAAAAAAAACAAACAAAAATAAAAGATAAA 
               
               
                   
                   
                 AATGAGCTATGTGAATTAAAAGAGGTATAACAATAGATAAACCATATTTTATTTAATTC 
               
               
                   
                   
                 CTAGTAATGAGTAATATTTCCAAACTTCTGGAATGGGCAGAAATTGCTAGTTGGCATA 
               
               
                   
                   
                 TTTTTACCTTTTATATTCAGATACATTAAAATTCTCAAAAAAAAACACCTCAAAGCAGA 
               
               
                   
                   
                 TGATCCGCCATCTCCTTGGATAATTTGTGTTAACTCAGGATAACAGAAAACCAAAATT 
               
               
                   
                   
                 ATGAGTTACTGATGCAATATTCCTAAATGTAAAAATAATTAAAGCTAATAGTAGATTCA 
               
               
                   
                   
                 TCTTCCAATTTCATATCAGTCTTACAAATAAACTACATATATAACTTGCTTGCCTTCCC 
               
               
                   
                   
                 TTCTGAGGGATAAAGCTGTTAGAAGAATTAAAATCAGCATTCTTGACTATTCAACCAA 
               
               
                   
                   
                 GGGAGGGATAAATTATTACTCATTCTAGGGACATGGGCTCATAACTACTACATGTGT 
               
               
                   
                   
                 AAGGACATGAATTTACCCAATATTACAATTTTTCCTTTTATTAGTGTGTACAGTGGAAG 
               
               
                   
                   
                 AATAGACATGTTCACTCTGGACAAAAAAAAAATTATACTTATCAGTTATCAGAAGCAC 
               
               
                   
                   
                 AATGCTGAAGACAGTAGTTCCATAACAATTTGAAGTATGTGATCGAACTAGTAGATTA 
               
               
                   
                   
                 TCTTAGTAGTAGTGAATTATTGTAAATGTTAGTAATTTGGCAGCCACTGGGCAGAAAA 
               
               
                   
                   
                 ATAAGAATTGAGGCTCAATATTGATATTAATGGTGGTGATTGACACATAAATTTTATCA 
               
               
                   
                   
                 AGTCTACACAATATAAAATTACAGAAAGGTAGAAGAGTATACCAGTACAACTTCAACA 
               
               
                   
                   
                 TATCTTCACTACAAGGGAGTAAAATGACATGGCCTAGTTACTATCTAATGAACTGCAG 
               
               
                   
                   
                 AAAACTAAAAGAAAACTCCAAGGCAACTCTTCTCTGCTGATCTGGTTGGTCCTTTTCC 
               
               
                   
                   
                 TACCTTTTGCAATACCCAGATACAAACAATGGATAGAAAACAAAGTAGACTTGTAGTA 
               
               
                   
                   
                 TGCAGGTCACAGTGCTAAATTCACAGAAAGAAACCCCTGAACTGAACTGCTCTATTT 
               
               
                   
                   
                 CCTGGTGGTCACAAAGAGTAATTCTGGTTTACACCTACAGATTGATGTCAATCTACAC 
               
               
                   
                   
                 CCTGTTGATAACAGTGTGGCCAAGGACAAAAAAAAGGTGCTCCGTTTTACCAATTCT 
               
               
                   
                   
                 GTAAAAAATTATTGGCAGGGTAAGCTCGGCTAGGGCAGGATTACATTTCTAGGACTA 
               
               
                   
                   
                 CCATCCCCGAAATTTAGAAGATATTATATCCACATAAAGCATATCTTTCACATTAATTT 
               
               
                   
                   
                 GCAAAAATCTAAAAGCTTTTTCTTAGCTCAAGTGTGTCCAAGTTTACCCTGGCAGTTT 
               
               
                   
                   
                 AAAACGATAGTTACAAGCAGCATGGGTTGTATCAGACACATTTGAGGGCCAATTTCA 
               
               
                   
                   
                 TGTAAGTGATATTGGGCAAGTTACTTCAACTATCTGTGCCTCCAAGGTCATACTAGTG 
               
               
                   
                   
                 TTTATTTACCTAAAGGGTACCTGTTATGTAACTTTAGGGTGTTTACATTAGATAATGCC 
               
               
                   
                   
                 TGCAAAATATTTACTTCAACGCCTAAAACATAGTTAAGTATTCAATAAATACCTACTAT 
               
               
                   
                   
                 TGTCACTACTAACTTAAAAGTTTAGAGATTAAGAGCAGAATCTGGGGTGAGACAAACT 
               
               
                   
                   
                 TAGGTTCAAATCCTAGTATTGTTGGGTAATCTTGGGCAAGTTACTTAACCTCTCTGAT 
               
               
                   
                   
                 TTGTGTAATTTAAAAAATTAGTTAATATACATAACAGGGCTTAGAAGAGTATCTAGCAC 
               
               
                   
                   
                 ATAGCACCATTTAAGCATTTGTTATTGCTAACATGCAAACAATTTAAGGGAAAGAAAT 
               
               
                   
                   
                 TTTTTAAAAAGGAAGAGGGATTTGCAAACTAAAAACAATGAGTATCTTATGTTCAAAG 
               
               
                   
                   
                 AAAACTAACAAACAGCCAGCTCTAGCAATAATTAAATTCACTATATACTGGGGCAGGC 
               
               
                   
                   
                 ATCACACCCCAAAGCTAAAAGCGTCTACCTAGGCCAGGCACGGTGGCTCATGCCTG 
               
               
                   
                   
                 TAATCCCAGCACTTTGGGAAGCAGAGGCGGGCAGATCGCTTGAGCTCAGGAGTTCA 
               
               
                   
                   
                 AGACCAGCCTGGACAACATGGCAAAACACCATCTCTACAAAAAATACAAATATTAGG 
               
               
                   
                   
                 CCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGT 
               
               
                   
                   
                 GGATCACCTGAGATCAGGAGTTCGAGAGTAGCCTGGCCAACATGGTGAAACCTCGT 
               
               
                   
                   
                 CTCTATTAAAAATACAAAAAATTAGCCAGGCATGGTGGCAGGCGCCTGTAATCCCAG 
               
               
                   
                   
                 CTACTCAGGGGGATGAGGTAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCA 
               
               
                   
                   
                 CTGAGCCGAGATCATGCCACTGTACTCCAGCCCGGGCAACAAGAGCGAAACTCCAT 
               
               
                   
                   
                 CTCAAAAAATAAATAAATAAATAAATAAAATAAAGTACAAATATTAGCCAGGGATGGT 
               
               
                   
                   
                 GGTGCGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAAGTGGGAGAATCCCCTGAG 
               
               
                   
                   
                 CCTGGGGAGAATCACCCGAGCCCGGGAAGTCGAGGCTGCAGTGAGCAGTGATTGT 
               
               
                   
                   
                 GCCACTGCACTCCATCCTAGGTGACAGAGTGAGACCCTGTCTCAAAAAAAAGAAATT 
               
               
                   
                   
                 GGCAGAATTAAGTAAGTTGATGTTTAGAGATGAAAAATCAACATTTTTTCCTCAGCAA 
               
               
                   
                   
                 CTGAATAAAAACAACAGCCACTACCATTTTTTTGAGTACCTATTTGTAGCCTATTTTTT 
               
               
                   
                   
                 AACTGGTATTACTCGAGAGAGAGAGAGCTAGGTTCGAGACAGAGCTCCTTCTCTTAA 
               
               
                   
                   
                 TAACTGTATGACCTAGGGTATGTCTGTTAGCCTCTCTGAGGCTTCAAAGGTTCCTCAT 
               
               
                   
                   
                 CTGTAAAATGGTAATAATCATACCATTGCTACAGGGCTGTTTTGAAGACTAATTAGGA 
               
               
                   
                   
                 CTATGTAAGTAAACATGATGATGGCTATTATTACTGTTCCCCGCCAGGGGCCATGCA 
               
               
                   
                   
                 AGGGTTGCTGATTCACATAGACTGTCTTATAATCCTCTCAATAACTCCAAGAGGTAGC 
               
               
                   
                   
                 CAGCACCTCAGATATACATAAAATGACTTAAGCCCAGAGAGGTGAAGTAAGTTGCCC 
               
               
                   
                   
                 ACAGCCACACAACTAGTAAATAGCCCAAACAAGCTGGATTCCCAGTTAGACTCCGTT 
               
               
                   
                   
                 AATAGCACTGCTCTTTACCTTAAGTCATTACAATGCCTAATATGAAATAGAATCGCTT 
               
               
                   
                   
                 CTTTCTTAGGGTTCAAGTGGTTAATTATTTAATGTATTCATTCAACAAACCATCATCGA 
               
               
                   
                   
                 GGACCTCTTACAAGCCAAGTACTGTGCTAAGTGCTAGAGTTACGGCGGTGATTCCTG 
               
               
                   
                   
                 CCCTTAAAAAGTTTTAGTGGGAGAAACAACAGGTAACCAGGTCATTGCCAAAACAAC 
               
               
                   
                   
                 AAAAATAATCATAATAAAGCAGGCTAAAGCATATTTAACTGGCCGGGGTTTTGACTAT 
               
               
                   
                   
                 TTTAGCAAGCATGATCAGAACGGTTGAGGAGGGAGGCCAGCAGCTTGGCCGGTTCA 
               
               
                   
                   
                 ACAAACAAGAAAAAACCAGTGAGGGTGGAGCTAAGATACCAGAGGCTGATTACGGT 
               
               
                   
                   
                 TAAGAATGTTCTTGAAGGTAAGGACCAGATTCTCATTTTCTATATCCTGGGGCATCGG 
               
               
                   
                   
                 TCAGCATGGAATCTGGATTCTAGCACATGTGAATTTCGGCTTGAAATGACCTAATGC 
               
               
                   
                   
                 CTTTTCCCTAGTTCCTTCGTGTGTCAAATACGCATGGTTACCGCTACCAGAGCTGTA 
               
               
                   
                   
                 GTGGGGCTTCAATGAGGCCATGAGCATCTCCATAAAGATGAACTACAGTGTGTGCAA 
               
               
                   
                   
                 AACTAAAGGCAAAACCTGGTCCCCACACGCCCTCCCAGGTGGTCGCTTTCCGTGCC 
               
               
                   
                   
                 GAGGCCCCTCCAGAGGTGCCCCGAGAACCTCACCATCGCACCCCAAACTTCCAGG 
               
               
                   
                   
                 GAAGGGCCTCTCCCGAGAAAGCCCCCACGCCCCCACCCCGCGCCATCATTCCCGA 
               
               
                   
                   
                 ATCTGCCCTCGGCCCCTCCCCGCAGCACGCTCGCAGGCGGCACATGTCAACCAAAA 
               
               
                   
                   
                 CGCCATTTCCACCTTCTCTTCCCACACGCAGTCCTCTTTTCCCAGGGCTCCCCCGAG 
               
               
                   
                   
                 GAGGGACCCACCCCAAACCCCGCCATTCCGTCCTCCCTGCCGCCCTCGCGTGACG 
               
               
                   
                   
                 TAAAGCCGAACCCGGGAAACTGGCCGCCCCCGCCTGCGGGGTTCCCTGGGCCCGG 
               
               
                   
                   
                 CCGCTCTAGAACTAGTGGATCCCAATTGAAGGCCTGGTCTAAATGACTCCAAAATCA 
               
               
                   
                   
                 CCACTTAATTCAAGAGACTGATTTCCCTGAGTCAGGCCCCTTAAAGCAGCTATTTCAA 
               
               
                   
                   
                 TGGGACAGGGAAACAACCCTAGGATCTGGATTAGAATCACTTGGGGGCTGCCACAC 
               
               
                   
                   
                 CCCCAGGGCTCTGATCCTGCCCTTCTCCCACACGCACATTCACATACTGCTGCAGTG 
               
               
                   
                   
                 ACCTTCCATTTCTAATGGGTTCCTGGGCCATCTGTCAGGTATAGGGAATGGAAAAGG 
               
               
                   
                   
                 GGTTGGGGAGGCTCTGCTTCAGAAAGTTTGTGTCAGGGGCTCCCAGAGCCTCCACA 
               
               
                   
                   
                 GATAGATAGCAGGGGTCCCCACCCTACCATGGCAGCTATAAATGTGATCAACATTTA 
               
               
                   
                   
                 TTGGCCTAGGATACAGCAGTTAGCAAAATGCCTGATGTAGTTCCCACTCCGTGGAGG 
               
               
                   
                   
                 TTGCAGGCTAGCTCTTTCCTAATGAGCTTTACAGCAGAAGCTGTTTTATCGTTAAGTG 
               
               
                   
                   
                 CCCCACAGAGACACTTTACCAGGAGGCTGGGAGAGTTCTCCAGATTTGGGAGAGGC 
               
               
                   
                   
                 GCAGAGACAGTGTGTGAGCCGAGCCCTGTCTCAGCAATCCACCTGGAGGAGCTAGA 
               
               
                   
                   
                 GTATCCTCCTCCCTTTACCATTCAGACCGAGAGAAAAAGCCCAGCTTGTGTGCACCC 
               
               
                   
                   
                 TCGTGGGGTTAAGGCGAGCTGTTCCTGGTTTAAAGCCTTTCAGTATTTGTTTTGATGT 
               
               
                   
                   
                 AAGGCTCTGTGGTTTGGGGGGGAACATCTGTAAACATTATTAGTTGATTTGGGGTTT 
               
               
                   
                   
                 GTCTTTGATGGTTTCTATCTGCAATTATCGTCATGTATATTTAAGTGTCTGTTATAGAA 
               
               
                   
                   
                 AACCCACACCCACTGTCCTGTAAACTTTTCTCAGTGTCCAGACTTTCTGTAATCACAT 
               
               
                   
                   
                 TTTAATTGCCACCTCGTATTTCACCTCTACATTTGAAATCTGGCGTCTGTTTCAAGCC 
               
               
                   
                   
                 AGTGTGTTTTTTCTTCGTTCTGTAATAAACAGCCAGGAGAAAAGTGCCTCTATGTTTT 
               
               
                   
                   
                 TATTTTTCAAGGGAGTATTCAGTACCTACAAACCCAAGTCAGGAAGCCTGCTAGTGG 
               
               
                   
                   
                 CTTTGGTTCTTTCAGAGGCTGCTCGATGCCTTGTGTGTCAGAAAGAAAGATTCAGCA 
               
               
                   
                   
                 GTTTTGCATCATGGCAAAGAAGCCTGTTATTTTGGGGCTCAGCCCCTCATTTTATAGA 
               
               
                   
                   
                 GGATGAAACAGAGGGGGATGGGAGGTCACAAAGACAACTGCCCCGGGAGCAGGTG 
               
               
                   
                   
                 TGGGGGAGACTTGCCCTGAGGGTCTAGACGCTCTGCACCACCGTCCTGTCTCCCTT 
               
               
                   
                   
                 GCTGAAGACCACACATGCCCTTCTTTGACCAGACCCTGCCACCTGATAGGCCAGGA 
               
               
                   
                   
                 CCTGGTAGGCGGGTACCCAGGTTTCATGGATGGAACCACATCTCCCCAAAAGTGGG 
               
               
                   
                   
                 GAGGTAGCTACTGGGATGCACGCCTCCCGCCATGTGCTATAGGAGAGCAGCTGAAG 
               
               
                   
                   
                 CAACAGTTGGGATCAGATGTAGTCACAATTGAATGCATCATCACATTTATCCCTCTAA 
               
               
                   
                   
                 GTGGCTGGGAGAGTTGATATCCTCATCCCTAAGGTACAAAATGTTCCAATTTGATCA 
               
               
                   
                   
                 GTGGCTTTCAGGAGCTGAGAAAGGCATGTGCTCTGAGGCAGAGCTGTTATGTCCCG 
               
               
                   
                   
                 CAGAGCCTAAAAATGCTCTAAGAACATGCTCCCTGCCAAAATTCTCAATGGCTGTGA 
               
               
                   
                   
                 CAAGGGACAACGATCGACCAATGGGGGTGGAAGCAGACCTCCGCAGTCCAGGGGC 
               
               
                   
                   
                 CAGAGCTAGGACAGAGGGGTCGGAGAAAGAGTCATTTTCCCAACACTCCAGCTCTT 
               
               
                   
                   
                 GGCCAGTCCTCACACAGTCCCCTCCTGCTTCCTGCTGAGAGAGATATCCTCATAGGT 
               
               
                   
                   
                 CTGGGTAAAGTCCTTCAGTCAGCTTTCATTCCCTGTCACCAACTTTGTCTCTGTTCTC 
               
               
                   
                   
                 CCTGCCCGTCTCAGGCAGCACTCCTCAGGAAACCTCTCCAAGAGCCAGCCTCACTG 
               
               
                   
                   
                 CAGCGCCCACTATTGTCCCTCTGCCTCAAGTGTCCCATCCATGCCAGGCCCCAGGC 
               
               
                   
                   
                 AGGCTGCAGCTTTCCCTCAGGGCCACACCAAAGCACTTGGGCTCAGCTGTGCTGTC 
               
               
                   
                   
                 CCCCTCCATCACTGAGCTCAGGGGCAGCAGGGGTGGGGTGCCAGGAGGCCCATTC 
               
               
                   
                   
                 ACCCTTCTCTGGCTCTGTGTTGGACCCACCTGCCCAGCCACTGCTGCTTAGAACCTA 
               
               
                   
                   
                 CCCGCTGGGAAAATGAAGCCCTCCCGGAGGGGCCACCTCAACCTGAGAGCCTCAC 
               
               
                   
                   
                 GGATCACAGTTGTCCCCACTCAGCTCTGCCAGCCCTCAGAGACCCATAGATAAAAG 
               
               
                   
                   
                 CTGAGCTTGGCTCGCAGAGCTGGTTCCATCTTCCATTCCCAGAGGGTTCAACTTCCT 
               
               
                   
                   
                 ACCCCAACCACACAGGGAACCTCAAGGCTGAGCCAGTGTGGGCTGCAGTGCAGAC 
               
               
                   
                   
                 CAGCTTCCTGGACACGTCCTGCCACCTGACCCCAGGCTGGCCTCACTGCCCCTGGC 
               
               
                   
                   
                 ACTCCTGACCCTATCCTCATTCCTCCTGGCAGTGCGTGTTCTGCCATTCCGCTTTCC 
               
               
                   
                   
                 CTTAGCTGTCCTCTCACTGTACTGTCAGCTTCTCCTTTTCCAGGTGCCCCCCAGGGG 
               
               
                   
                   
                 CTTTCCACATGACCCTGTCACCCCACAGCCCATCCAGCACCAATTCCAGCTCTCTGC 
               
               
                   
                   
                 CACCCTTCAAAGGAGTGACAGTGCCCTGCTTCACCTCCCACTCACCCCTCAACCCA 
               
               
                   
                   
                 GAGCAATCTGGCTCCAGTCTTGCCTCCTTCCCCCTAAGTACTCTAGTCACAGTTCCA 
               
               
                   
                   
                 AATTCCTCCTGGTCATAAAGCCAAATGAAGCTTCCTGGTCCTCAGCGGACTTGCCAC 
               
               
                   
                   
                 TTCAGCAGTACTGGACTCTCTCCTCCCAGAAACCTGTTTCCCCTTGGCTCCTGGAGC 
               
               
                   
                   
                 CCACACTCTGCTGGAATCCTTCTGCCTCTCTGGCCTGTAGCCTGGCCCTCTCTCCCA 
               
               
                   
                   
                 ACCTGAGGTCCATTCTCTCCTGCTCCTCCACAAGATGTTGCTCCTTCCATTACTTCCT 
               
               
                   
                   
                 CCCTCTCAACCAAAGCTCCTTCATTAGCTCTTTATCTTCTGGTTTCTTCCCCTGGGCA 
               
               
                   
                   
                 GACGAATGGATTCAAGAGCCTGTGGCCCAGCAGCCCAGCACTCCAGGATCTCAGCA 
               
               
                   
                   
                 CTTCAGCATCCCAGTACCCTAGCATCTCAATACCCCAGCACCCCAGCACCATAGTAT 
               
               
                   
                   
                 TCCAGCACCCCATTGTCCAAGCATCTCAGCACTCCAGCATCCCAGCACCCCAACACT 
               
               
                   
                   
                 CCAGCAGCCCAGAATCTCAGCACCCTAGCACTGCAGCATCTCAGGACCCCAGCACT 
               
               
                   
                   
                 TCAGCATCCCAGCACACTAGTACTCCAGCATCTCGGCACCCCAGCACCTAGGCATC 
               
               
                   
                   
                 CCAACACCCAGCACCCCAGCACTTAAGCATCCCACCACTACAGTATCTCAACACTCC 
               
               
                   
                   
                 AGCACCCCAGCACCATAGTGTTCCAGCACCCCAGCATCCCAACACCCCAGCACTTA 
               
               
                   
                   
                 AGCATCCCAACACCTCGGCATCCCAACACCCCAGCACTGCAGCATCTCAGCACCTT 
               
               
                   
                   
                 AGCATCCCAGTGCCCTAGCATCTCAATGCTCCAGCACACCAGTACTACAGTATTCCA 
               
               
                   
                   
                 GCACCCCAGCACTCCAGCATCTCAGCACTGCAGCACTGCAGCACTCCAGCATCCCA 
               
               
                   
                   
                 AAATCCCAGCATCCCAACACCCCAGCAGACCAGCAGACCAGCATCTCAGCACCGCA 
               
               
                   
                   
                 GCATCCAAGGACTATCCCAGCATCCCAGCAACCCAGCACCTCAGCATCCCAACACC 
               
               
                   
                   
                 CCAGCATTTCAGCATGGCAACACCCCAGTACCCCAGCACTTCAGCACCCCAGTATC 
               
               
                   
                   
                 CCAGCATCTCAGCGACCCAGTATCACAAAACCTCAGCATCCTAGCACCCCAGCACC 
               
               
                   
                   
                 CCAGCACCTTAGCACCTTAGCATCCCAGCATCTCAGCGCCTCAGCATCTTGATATTC 
               
               
                   
                   
                 TGGCTGAGGTCAGCGTGGTGTATCTAGTCAGGGTCCTAACTTTCACTTCGCAGGGA 
               
               
                   
                   
                 AATGCTGCTGGACTGGGTCTCATGTTGGGCTGAAGCTCTCTAGACCCCTTGAAGACA 
               
               
                   
                   
                 GCATAAAAGAGCTTGGAGACGCTGGGTGTCCCCCATGGAAGAGTTCACTCTCATCC 
               
               
                   
                   
                 TGCTTTGACAACAGCCTTCTCTGGGGTCCCTCACGGGCCCCTCTTTCTTACTGCAAG 
               
               
                   
                   
                 TTTGTCTCTGAGAAGACTGTGATGCAGAAGTCACTCAGCTGCCTGTGGCTCCTGAAG 
               
               
                   
                   
                 AGCTGAAGGTGGAGGCCTGTAGGCCTCCCTATGAGAGGCGCAGAAAAAACCATGAT 
               
               
                   
                   
                 TGCTAGTGGGGAGGTGCTCCCTCTACAACCCACTCCATAATCTGCCCCCGCCCAGC 
               
               
                   
                   
                 TCTGAGGCCAGCCCCAGGGGAAAATGCCAGATCCCCAGGGAGGTGTGTGAGACCT 
               
               
                   
                   
                 CAGGGGCTCCCTCCTCCCTTACAGCAGGCTCAGGCCCCTGGGGGCCTCAGGGCCA 
               
               
                   
                   
                 AGGTCTGTGGGTAAGCTACTATCTCTCACTTGTCCTCTAGCCACAAAAGCCAGGGAG 
               
               
                   
                   
                 ATCTGGCAATGGACATGAGGTTCTGAAGAAGCACATATGACTGGCTTCCTAATGCGT 
               
               
                   
                   
                 GGTTGTTCAGTGATTCAATAAACACGCATGGGCCAGGCATGGGGAAATAGACAAACA 
               
               
                   
                   
                 TGATCCCCAACCTCTCCCAGAGTGAACTGGGAGGGAGGAGTGTTCATCCCTCAGGA 
               
               
                   
                   
                 TTACACCAGAGAAACAAACCAGCAGGAGATATATATGGTTTTGGGGGGTCAAGAAAG 
               
               
                   
                   
                 AGGAAAAACCTGGCAAGGCAAGTCCAAAATCATAGGACAGGCTGTCAGGAAGGGCA 
               
               
                   
                   
                 GCCTGGAACCTCTCAAGCAGGAGCTGATGCTGCAGTCCACAGGCAGAATTTCTTCTT 
               
               
                   
                   
                 CCTCGGGGAAATCTCAGCTTTGTTCTTAAGGCCTTTCAACTGATTGGCTGAGGTCTG 
               
               
                   
                   
                 CCCCTTCCCCCACATTCTCCAGGATAATCTTCCTTACTTAAAGTCAACTATTAATCAC 
               
               
                   
                   
                 AGCTACAAAATCCCTTCACAGCTACACATAGATCAGTGTTTGATTGACGAACAGCCC 
               
               
                   
                   
                 CTACAGCCTAGCCAAGTTGACACATAAAACTAACCATCACAGGGGGACAAATGATGT 
               
               
                   
                   
                 AAACACATCAACAAATAAAACAGTAACAAGTTAAGGTCTATGGAAAAAACACAGAAGG 
               
               
                   
                   
                 GGCAGAGAGAAAGAAAGCAAGAAGGAGAGTCCCAGTTTGCTAGGGCTTGTGGGAAG 
               
               
                   
                   
                 TGGGGAGCAGTTCTCTTTAGCTAGGATATTTGGGAAAGGCATATCTGAAGGAGTGAT 
               
               
                   
                   
                 ATTTGAGCTTAGATTAAAAGATGGGAAGGAGCAAGCCATGCAAAGAGCTAGGATGTT 
               
               
                   
                   
                 CCAAGCAGAGACGGAACAGCAAGTGCAAATGTCAGGAGGAATAGAAGGAGGCTGGT 
               
               
                   
                   
                 GGGTGGGGTCCAGTGAGCAAGAGGAGGGCAGGCAGGAGAGGGGATGGGGAGGTG 
               
               
                   
                   
                 GGCAGGCCCAGACCACCCAGGGCCCTGGAGACTATCCTGATCCAACAAGGGAAGC 
               
               
                   
                   
                 CTTGAGTCACTTCAGTGTCCATGTGGAGAATGGACCTCAGACTGAATGAGGGAGGC 
               
               
                   
                   
                 AGTAAGGAGGGCCTCTACCTCCAGGGCTTCGCCCTGTGGACTGCGCATAGACATCT 
               
               
                   
                   
                 CCAACTCAGAAAGTCTGAACCAAACTTTCCATAGTTCCCCCAAGTCTGGGCATCCTC 
               
               
                   
                   
                 CTACTCAGTGAAAGGCAGCCATCACACCTCCCTGCCCTGCTCCCGGATGCCCCAAA 
               
               
                   
                   
                 TCCTCTTGGTCTCCAAGTCCAGAACCTGAGACTTGTCCTTGATGTTTGTCTTTCCCTC 
               
               
                   
                   
                 ACCCTTTCTGTATTCTGGGAAGATGGGTTTTTTTCCCCCAGATGAATCTGTAAAACTT 
               
               
                   
                   
                 CTGTGATCACAATAAAAATTCTGGCAGTATTATTTTCTGGAACATGACAAAGTGATTC 
               
               
                   
                   
                 AAAATTATTTATCTGGAAGACTACAAAACAAGAATAGCCAGGAAATTTCTAAAAAGAA 
               
               
                   
                   
                 AGAAGAAGGAGGAGGAGAAAGAAGGAGGAGGAAAAGGAGGAGAAGAAGAAAAGAA 
               
               
                   
                   
                 AAAGAACCAAGAAAGGGTTCTAGCTCTACCAAATATTAAAACATATCATGAAGCTATT 
               
               
                   
                   
                 TAAAACAATATGGTTGTGGATACTGAAAAAGATGTGAATAAAGTGGAAGGAAAATAAA 
               
               
                   
                   
                 TAGAAATGCACATGGGGATTGAGACTGTGAAAAAGGCAGCATCTCACATCAGTGAG 
               
               
                   
                   
                 GGATGTTCAACACCTGGTGTTGGGAAAACTGGCTAGTCATTTAAACCAAACAACTGG 
               
               
                   
                   
                 GTCCTCTACCTCACTCCTGACATTAAGATACATTTAGATGATTCAAAGAGTAAGACAG 
               
               
                   
                   
                 AAAAAATAACACGTGAAAACACTATCAGAAAACAACGTGGGCCAGGTGTGGTGGGTC 
               
               
                   
                   
                 ACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGACAGATCACCTGAGGTGG 
               
               
                   
                   
                 GGAGTTCAAGACCAGCCTGACCAACATGGTGAAATCCTGTCTCTACTAAAAATACAA 
               
               
                   
                   
                 AATTAGCTGAGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCCGAGG 
               
               
                   
                   
                 CAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGTGGTGAGCCGAGATCACGCCA 
               
               
                   
                   
                 TTGCACTCCAGCCTGGGCAACAAGAGTGAAAATCCATCTAAAAAAAAAAAAAAAAGC 
               
               
                   
                   
                 CAAGGTGGATATTTTTATAGTATCAGGGTAGATCAAGCTTCTCCAATCATGACATGAA 
               
               
                   
                   
                 ACCCAGAAACCATAAAAGAAAAGAATGATAAAATTGCCCACGTAAAGTAAAAAGCTTG 
               
               
                   
                   
                 CACACAGAAAAACACCATACAGGTTACAAGATGAGCAGCAAAATCAGAGAAAAAACA 
               
               
                   
                   
                 TTGCAATTCAGGACACACAGAGGCTATTGTTCCTAATATTTAAAAATAAAAGTAGTGG 
               
               
                   
                   
                 ATTGTCTACAAAAAGATGAAGACAAGAATTTCAGAAAACCAAATACTGCATGTTTTCA 
               
               
                   
                   
                 CTTACAAGTGGAAGCTAAACACTGAGTACACGTGTACACAAAGAATGGAACCATAGG 
               
               
                   
                   
                 CCAGGCACCGTGGCTCACGCCTGTAATCCCAGTACTTTGCGAGGCCGAAGCGGGC 
               
               
                   
                   
                 GGATCACCTGAGGTGAGGAGTTCGAGACCATCCTGGCCAACATGGTGAAACCCAGT 
               
               
                   
                   
                 CTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGGTGGGTGCCTGTAATCCCAGC 
               
               
                   
                   
                 TACTCGGGAGGCTGCGGCAGTAGAATCGCTTGAACCCTGGAGGTGGACCTTGCAGT 
               
               
                   
                   
                 GAGCCGAGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCATCTC 
               
               
                   
                   
                 AAAAAAAAAAAAAAGGAATAGAACAATAGACACTGGGGCCTACTTGAGGGAGGAGG 
               
               
                   
                   
                 GTGAGGATCAAAAACCTGCCTATCAGGTACTATGCTTATTACCTGGGTGGTGAAATA 
               
               
                   
                   
                 ATCTGTACACCAAACCCCAGTGACATGCAATTTACCGATGTAACAAACCTGCCCATG 
               
               
                   
                   
                 TACCCGCTGAACCTAAAATAAAAGTTGGAAAAAAATATAGAAATTTTCTTTGTAATAGC 
               
               
                   
                   
                 CAAAAACTGCAAACAGCCCAGGTGTCTATTAGTAGAATGCATAAACAAACTCGGGCA 
               
               
                   
                   
                 TGTTCATACAATGTAAAACTACTCATCAATAAAAAGTGATACTTCTCAGCAATGAAAA 
               
               
                   
                   
                 GAAACTAGCTACTGATACCAGCTACAACATGGATGGATTTCAAGTGCTTTATGATGA 
               
               
                   
                   
                 GAGCAAGAAGCCAGACACAAAAGTGTCTATATATATATACAGTATATATACGTATATA 
               
               
                   
                   
                 TACACATATATACAGTATATATATACATATACATGTATATATATACTGTATATATACTGT 
               
               
                   
                   
                 ATATATATACACAGTATATATATACATATATACAGTGTATATATACTGTGTATATATACA 
               
               
                   
                   
                 TGTATATATACTGTGTATATATACATGTATATATACTGTGTATATATACATGTATATATA 
               
               
                   
                   
                 CTGTGTATATATACATGTATATATATGTATACTGTATATATACTGTATATATATATACAC 
               
               
                   
                   
                 ATATATACAGTATATATATACAGTATATACTGTATATATACAGTATATACGTGTATATAT 
               
               
                   
                   
                 ACATATATACAGTATATATGTAAATATACATATATACAGTATATATGTAAATATACATAT 
               
               
                   
                   
                 ATACATGTATATATATACACTATATATATACATATATAGTGTATATATACATATATACAT 
               
               
                   
                   
                 GTATATATTTACTATATGATTCCATTTATATAAAGTGCCAAAACAGTCAAAAATAATCT 
               
               
                   
                   
                 ATGTGGAAAAAATCAACAAAGGGATCCCCCGGGCTGCAGGAATTCGATGGCGCGCC 
               
               
                   
                   
                 GACGTCGCATGCAGTTAGGGATAACAGGGTAATACGACCATGGCATGTCCTCTAGA 
               
               
                   
                   
                 CTCGAGCGGCCGCAATAAAATATCTTTATTTTCATTACATCTGTGTGTTGGTTTTTTGT 
               
               
                   
                   
                 GTGAATCGTAACTAACATACGCTCTCCATCAAAACAAAACGAAACAAAACAAACTAGC 
               
               
                   
                   
                 AAAATAGGCTGTCCCCAGTGCAAGTGCAGGTGCCAGAACATTTCTCTATCGAAGGAT 
               
               
                   
                   
                 CTGCGATCGCTCCGGTGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCC 
               
               
                   
                   
                 GAGAAGTTGGGGGGAGGGGTCGGCAATTGAACCGGTGCCTAGAGAAGGTGGCGCG 
               
               
                   
                   
                 GGGTAAACTGGGAAAGTGATGTCGTGTACTGGCTCCGCCTTTTTCCCGAGGGTGGG 
               
               
                   
                   
                 GGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAACGGGTTT 
               
               
                   
                   
                 GCCGCCAGAACACAGCTGAAGCTTCGAGGGGCTCGCATCTCTCCTTCACGCGCCCG 
               
               
                   
                   
                 CCGCCCTACCTGAGGCCGCCATCCACGCCGGTTGAGTCGCGTTCTGCCGCCTCCC 
               
               
                   
                   
                 GCCTGTGGTGCCTCCTGAACTGCGTCCGCCGTCTAGGTAAGTTTAAAGCTCAGGTC 
               
               
                   
                   
                 GAGACCGGGCCTTTGTCCGGCGCTCCCTTGGAGCCTACCTAGACTCAGCCGGCTCT 
               
               
                   
                   
                 CCACGCTTTGCCTGACCCTGCTTGCTCAACTCTACGTCTTTGTTTCGTTTTCTGTTCT 
               
               
                   
                   
                 GCGCCGTTACAGATCCAAGCTGTGACCGGCGCCTACGTAAGTGATATCTACTAGATT 
               
               
                   
                   
                 TATCAAAAAGAGTGTTGACTTGTGAGCGCTCACAATTGATACTTAGATTCATCGAGAG 
               
               
                   
                   
                 GGACACGTCGACTACTAACCTTCTTCTCTTTCCTACAGCTGAGATCACCGGCGAAGG 
               
               
                   
                   
                 AGGGCCACCATGGGTCACCAGCAGTTGGTCATCTCTTGGTTTTCCCTGGTTTTTCTG 
               
               
                   
                   
                 GCATCTCCCCTCGTGGCCATATGGGAACTGAAGAAAGATGTTTATGTCGTAGAATTG 
               
               
                   
                   
                 GATTGGTATCCGGATGCCCCTGGAGAAATGGTGGTCCTCACCTGTGACACCCCTGA 
               
               
                   
                   
                 AGAAGATGGTATCACCTGGACCTTGGACCAGAGCAGTGAGGTCTTAGGCTCTGGCA 
               
               
                   
                   
                 AAACCCTGACCATCCAAGTCAAAGAGTTTGGAGATGCTGGCCAGTACACCTGTCACA 
               
               
                   
                   
                 AAGGAGGCGAGGTTCTAAGCCATTCGCTCCTGCTGCTTCACAAAAAGGAAGATGGA 
               
               
                   
                   
                 ATTTGGTCCACTGATATTTTAAAGGACCAGAAAGAACCCAAAAATAAGACCTTTCTAA 
               
               
                   
                   
                 GATGCGAGGCCAAGAATTATTCTGGACGTTTCACCTGCTGGTGGCTGACGACAATCA 
               
               
                   
                   
                 GTACTGATTTGACATTCAGTGTCAAAAGCAGCAGAGGCTCTTCTGACCCCCAAGGGG 
               
               
                   
                   
                 TGACGTGCGGAGCTGCTACACTCTCTGCAGAGAGAGTCAGAGGGGACAACAAGGA 
               
               
                   
                   
                 GTATGAGTACTCAGTGGAGTGCCAGGAGGACAGTGCCTGCCCAGCTGCTGAGGAG 
               
               
                   
                   
                 AGTCTGCCCATTGAGGTCATGGTGGATGCCGTTCACAAGCTCAAGTATGAAAACTAC 
               
               
                   
                   
                 ACCAGCAGCTTCTTCATCAGGGACATCATCAAACCTGACCCACCCAAGAACTTGCAG 
               
               
                   
                   
                 CTGAAGCCATTAAAGAATTCTCGGCAGGTGGAGGTCAGCTGGGAGTACCCTGACAC 
               
               
                   
                   
                 CTGGAGTACTCCACATTCCTACTTCTCCCTGACATTCTGCGTTCAGGTCCAGGGCAA 
               
               
                   
                   
                 GAGCAAGAGAGAAAAGAAAGATAGAGTCTTCACGGACAAGACCTCAGCCACGGTCA 
               
               
                   
                   
                 TCTGCCGCAAAAATGCCAGCATTAGCGTGCGGGCCCAGGACCGCTACTATAGCTCA 
               
               
                   
                   
                 TCTTGGAGCGAATGGGCATCTGTGCCCTGCAGTGTTCCTGGAGTAGGGGTACCTGG 
               
               
                   
                   
                 GGTGGGCGCCAGAAACCTCCCCGTGGCCACTCCAGACCCAGGAATGTTCCCATGC 
               
               
                   
                   
                 CTTCACCACTCCCAAAACCTGCTGAGGGCCGTCAGCAACATGCTCCAGAAGGCCAG 
               
               
                   
                   
                 ACAAACTCTAGAATTTTACCCTTGCACTTCTGAAGAGATTGATCATGAAGATATCACA 
               
               
                   
                   
                 AAAGATAAAACCAGCACAGTGGAGGCCTGTTTACCATTGGAATTAACCAAGAATGAG 
               
               
                   
                   
                 AGTTGCCTAAATTCCAGAGAGACCTCTTTCATAACTAATGGGAGTTGCCTGGCCTCC 
               
               
                   
                   
                 AGAAAGACCTCTTTTATGATGGCCCTGTGCCTTAGTAGTATTTATGAAGACTTGAAGA 
               
               
                   
                   
                 TGTACCAGGTGGAGTTCAAGACCATGAATGCAAAGCTGCTGATGGATCCTAAGAGG 
               
               
                   
                   
                 CAGATCTTTCTAGATCAAAACATGCTGGCAGTTATTGATGAGCTGATGCAGGCCCTG 
               
               
                   
                   
                 AATTTCAACAGTGAGACTGTGCCACAAAAATCCTCCCTTGAAGAACCGGATTTTTATA 
               
               
                   
                   
                 AAACTAAAATCAAGCTCTGCATACTTCTTCATGCTTTCAGAATTCGGGCAGTGACTAT 
               
               
                   
                   
                 TGATAGAGTGATGAGCTATCTGAATGCTTCCTAAAAAGCGAGGTCCCTCCAAACCGT 
               
               
                   
                   
                 TGTCATTTTTATAAAACTTTGAAATGAGGAAACTTTGATAGGATGTGGATTAAGAACTA 
               
               
                   
                   
                 GGGAGGGGCTAGCTCGACATGATAAGATACATTGATGAGTTTGGACAAACCACAACT 
               
               
                   
                   
                 AGAATGCAGTGAAAAAAATGCTTTATTTGTGAAATTTGTGATGCTATTGCTTTATTTGT 
               
               
                   
                   
                 GAAATTTGTGATGCTATTGCTTTATTTGTAACCATTATAAGCTGCAATAAACAAGTTAA 
               
               
                   
                   
                 CAACAACAATTGCATTCATTTTATGTTTCAGGTTCAGGGGGAGGTGTGGGAGGTTTT 
               
               
                   
                   
                 TTAAAGCAAGTAAAACCTCTACAAATGTGGTAGATCCATTTATTAGCTAGGAGTTTCA 
               
               
                   
                   
                 GAAAAGGGGGCCTGAGTGGCCCCTTTTTTCAACTTAATTAACCTGCAGGGCCTGAAA 
               
               
                   
                   
                 TAACCTCTGAAAGAGGAACTTGGTTAGGTACCTTCTGAGGCTGAAAGAACCAGCTGT 
               
               
                   
                   
                 GGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGT 
               
               
                   
                   
                 ATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCC 
               
               
                   
                   
                 CCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCA 
               
               
                   
                   
                 CTAGTTTCATCACCACCGCCACCCCCCCGCCCCCCCGCCATCTGAAAGGGTTCTAG 
               
               
                   
                   
                 GGGATTTGCAACCTCTCTCGTGTGTTTCTTCTTTCCGAGAAGCGCCGCCACACGAGA 
               
               
                   
                   
                 AAGCTGGCCGCGAAAGTCGTGCTGGAATCACTTCCAACGAAACCCCAGGCATAGAT 
               
               
                   
                   
                 GGGAAAGGGTGAAGAACACGTTGTCATGGCTACCGTTTCCCCGGTCACGGAATAAA 
               
               
                   
                   
                 CGCTCTCTAGGATCCGGAAGTAGTTCCGCCGCGACCTCTCTAAAAGGATGGATGTG 
               
               
                   
                   
                 TTCTCTGCTTACATTCATTGGACGTTTTCCCTTAGAGGCCAAGGCCGCCCAGGCAAA 
               
               
                   
                   
                 GGGGCGGTCCCACGCGTGAGGGGCCCGCGGAGCCATTTGATTGGAGAAAAGCTGC 
               
               
                   
                   
                 AAACCCTGACCAATCGGAAGGAGCCACGCTTCGGGCATCGGTCACCGCACCTGGAC 
               
               
                   
                   
                 AGCTCCGATTGGTGGACTTCCGCCCCCCCTCACGAATCCTCATTGGGTGCCGTGGG 
               
               
                   
                   
                 TGCGTGGTGCGGCGCGATTGGTGGGTTCATGTTTCCCGTCCCCCGCCCGCGAGAA 
               
               
                   
                   
                 GTGGGGGTGAAAAGCGGCCCGACCTGCTTGGGGTGTAGTGGGCGGACCGCGCGG 
               
               
                   
                   
                 CTGGAGGTGTGAGGATCCGAACCCAGGGGTGGGGGGTGGAGGCGGCTCCTGCGA 
               
               
                   
                   
                 TCGAAGGGGACTTGAGACTCACCGGTCGCACGTCATGAATCTAGAACCATGGCTTC 
               
               
                   
                   
                 GTACCCCGGCCATCAGCACGCGTCTGCGTTCGACCAGGCTGCGCGTTCTCGCGGC 
               
               
                   
                   
                 CATAGCAACCGACGTACGGCGTTGCGCCCTCGCCGGCAGCAAGAAGCCACGGAAG 
               
               
                   
                   
                 TCCGCCCGGAGCAGAAAATGCCCACGCTACTGCGGGTTTATATAGACGGTCCCCAC 
               
               
                   
                   
                 GGGATGGGGAAAACCACCACCACGCAACTGCTGGTGGCCCTGGGTTCGCGCGACG 
               
               
                   
                   
                 ATATCGTCTACGTACCCGAGCCGATGACTTACTGGCGGGTGCTGGGGGCTTCCGAG 
               
               
                   
                   
                 ACAATCGCGAACATCTACACCACACAACACCGCCTTGACCAGGGTGAGATATCGGC 
               
               
                   
                   
                 CGGGGACGCGGCGGTGGTAATGACAAGCGCCCAGATAACAATGGGCATGCCTTAT 
               
               
                   
                   
                 GCCGTGACCGACGCCGTTCTGGCTCCTCATATCGGGGGGGAGGCTGGGAGCTCAC 
               
               
                   
                   
                 ATGCCCCGCCCCCGGCCCTCACCCTCATCTTCGACCGCCATCCCATCGCCGCCCTC 
               
               
                   
                   
                 CTGTGCTACCCGGCCGCGCGATACCTTATGGGCAGCATGACCCCCCAGGCCGTGC 
               
               
                   
                   
                 TGGCGTTCGTGGCCCTCATCCCGCCGACCTTGCCCGGCACAAACATCGTGTTGGGG 
               
               
                   
                   
                 GCCCTTCCGGAGGACAGACACATCGACCGCCTGGCCAAACGCCAGCGCCCCGGCG 
               
               
                   
                   
                 AGCGGCTTGACCTGGCTATGCTGGCCGCGATTCGCCGCGTTTACGGGCTGCTTGCC 
               
               
                   
                   
                 AATACGGTGCGGTATCTGCAGGGCGGCGGGTCGTGGCGGGAGGATTGGGGACAGC 
               
               
                   
                   
                 TTTCGGGGACGGCCGTGCCGCCCCAGGGTGCCGAGCCCCAGAGCAACGCGGGCC 
               
               
                   
                   
                 CACGACCCCATATCGGGGACACGTTATTTACCCTGTTTCGGGCCCCCGAGTTGCTG 
               
               
                   
                   
                 GCCCCCAACGGCGACCTGTACAACGTGTTTGCCTGGGCCTTGGACGTCTTGGCCAA 
               
               
                   
                   
                 ACGCCTCCGTCCCATGCACGTCTTTATCCTGGATTACGACCAATCGCCCGCCGGCT 
               
               
                   
                   
                 GCCGGGACGCCCTGCTGCAACTTACCTCCGGGATGATCCAGACCCACGTCACCACC 
               
               
                   
                   
                 CCAGGCTCCATACCGACGATCTGCGACCTGGCGCGCACGTTTGCCCGGGAGATGG 
               
               
                   
                   
                 GGGAGGCTAACTGAGTATACCCTAGGATTATCCCTAATACCTGCCACCCCACTCTTA 
               
               
                   
                   
                 ATCAGTGGTGGAAGAACGGTCTCAGAACTGTTTGTTTCAATTGGCCATTTAAGTTTAG 
               
               
                   
                   
                 TAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGGAG 
               
               
                   
                   
                 AATGTTTTGTGGACCACTTTGGTTTTCTTTTTTGCGTGTGGCAGTTTTAAGTTATTAGT 
               
               
                   
                   
                 TTTTAAAATCAGTACTTTTTAATGGAAACAACTTGACCAAAAATTTGTCACAGAATTTT 
               
               
                   
                   
                 GAGACCCATTAAAAAAGTTAAATGAGAAACCTGTGTGTTCCTTTGGTCAACACCGAG 
               
               
                   
                   
                 ACATTTAGGTGAAAGACATCTAATTCTGGTTTTACGAATCTGGAAACTTCTTGAAAAT 
               
               
                   
                   
                 GTAATTCTTGAGTTAACACTTCTGGGTGGAGAATAGGGTTGTTTTCCCCCCACATAAT 
               
               
                   
                   
                 TGGAAGGGGAAGGAATATCATTTAAAGCTATGGGAGGGTTTCTTTGATTACAACACT 
               
               
                   
                   
                 GGAGAGAAATGCAGCATGTTGCTGATTGCCTGTCACTAAAACAGGCCAAAAACTGAG 
               
               
                   
                   
                 TCCTTGGGTTGCATAGAAAGCTGCCTGCAGGCGTTACATAACTTACGGTAAATGGCC 
               
               
                   
                   
                 CGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTT 
               
               
                   
                   
                 CCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGG 
               
               
                   
                   
                 TAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATT 
               
               
                   
                   
                 GACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATG 
               
               
                   
                   
                 GGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGATGATG 
               
               
                   
                   
                 CGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCC 
               
               
                   
                   
                 AAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGACTAGTTACCGGCGGAAA 
               
               
                   
                   
                 CGGTCTCGGGTTGAGAGGTCACCCGAGGGACAGGCAGCTGCTGAACCAATAGGAC 
               
               
                   
                   
                 CGGCGCACAGGGCGGATGCTGCCCCTCATTGGCGGCCGTTGAGAGTGACCAAGAG 
               
               
                   
                   
                 CCAATGAGTCAGCCCGGGGGGCGTAGCAGTGACGTAAGTTGCGGAGGAGGCCGCT 
               
               
                   
                   
                 TCGAATCGGCAGCGGCCAGCTTGGTGGCATGGACCAATCAGCGTCCTCCAACGAG 
               
               
                   
                   
                 GAGCGCCTTCGCCAATCGGAGGCCTCCACGACGGGGCTGGGGGGAGGGTATATAA 
               
               
                   
                   
                 GCCGAGTCGGCGGCGGCGCGCTCCACACGGGCCGAGACCACAGCGACGGGAGCG 
               
               
                   
                   
                 TCTGCCTCTGCGGGGCCGAGAGGTAAGCGCCGCGGCCTGCCCTTTCCAGGCCAAC 
               
               
                   
                   
                 TCGGAGCCCGTCTCGTGGCTCCGCCTGATCGGGGGCTCCTGTCGCCCTCAGATCG 
               
               
                   
                   
                 GTCGGAACGCCGTCGCGCTCCGGGACTACAAGCCTGTTGCTGGGCCCGGAGACTG 
               
               
                   
                   
                 CCGAAGGACCGCTGAGCACTGTCCTCAGCGCCGGCACCATGGATTGGATCTGGCG 
               
               
                   
                   
                 GATCCTGTTCCTTGTGGGAGCTGCCACAGGCGCCCATTCTGAAGTTCAGCTGGTTC 
               
               
                   
                   
                 AGTCTGGCGCCGAAGTGAAGAAACCTGGCGCCTCTGTGAAGGTGTCCTGCAAAGCT 
               
               
                   
                   
                 TCTGGCGGCACCTTCAGCAGCTACGCCATCTCTTGGGTTCGACAGGCCCCTGGACA 
               
               
                   
                   
                 AGGCCTGGAATGGATGGGCAGAATCATCCCCATCCTGGGAATCGCCAACTACGCCC 
               
               
                   
                   
                 AGAAATTCCAGGGCAGAGTGACCATCACCGCCGACAAGAGCACAAGCACCGCCTAC 
               
               
                   
                   
                 ATGGAACTGAGCAGCCTGAGAAGCGAGGACACCGCCGTGTACTACTGTGCCAGAAG 
               
               
                   
                   
                 CGGCCACGGCTACAGCTACGGCGCCTTTGATTATTGGGGCCAGGGCACCCTGGTCA 
               
               
                   
                   
                 CCGTTTCTAGCGGAGGCGGAGGTAGTGGTGGCGGAGGTTCAGGCGGCGGAGGATC 
               
               
                   
                   
                 TCAATCTGTGCTGACACAGCCTCCAAGCGTGTCAGGTGCTCCTGGCCAGAGAGTGA 
               
               
                   
                   
                 CAATCAGCTGTACAGGCAGCAGCAGCAACATCGGAGCCGGCTATGACGTGCACTGG 
               
               
                   
                   
                 TATCAGCAGCTGCCTGGCACAGCCCCTAAACTGCTGATCTACGGCAACAGCAACAG 
               
               
                   
                   
                 ACCCAGCGGCGTGCCCGATAGATTTTCCGGCTCTAAGAGCGGCACAAGCGCCAGC 
               
               
                   
                   
                 CTGGCTATTACTGGACTGCAGGCCGAGGACGAGGCCGACTACTACTGTCAGAGCTA 
               
               
                   
                   
                 CGACAGCAGCCTGTCCGGCAGCTACGTTGTGTTTGGCGGCGGAACAAAGCTGACC 
               
               
                   
                   
                 GTGCTGGAAGCCAAGAGCTGCGACAAGACCCACACCTGTCCTCCATGTCCTGCTCC 
               
               
                   
                   
                 AGAACTGCTCGGCGGACCTTCCGTGTTCCTGTTTCCTCCAAAGCCTAAGGACACCCT 
               
               
                   
                   
                 GATGATCAGCAGAACCCCTGAAGTGACCTGCGTGGTGGTGGATGTGTCCCACGAGG 
               
               
                   
                   
                 ACCCAGAAGTGAAGTTCAATTGGTACGTGGACGGCGTGGAAGTGCACAACGCCAAG 
               
               
                   
                   
                 ACCAAGCCTAGAGAGGAACAGTACAACAGCACCTACAGAGTGGTGTCCGTGCTGAC 
               
               
                   
                   
                 AGTGCTGCACCAGGATTGGCTGAACGGCAAAGAGTACAAGTGCAAGGTGTCCAACA 
               
               
                   
                   
                 AGGCCCTGCCTGCTCCTATCGAGAAAACCATCAGCAAGGCCAAGGGCCAGCCTAGG 
               
               
                   
                   
                 GAACCCCAGGTTTACACACTGCCACCTAGCAGGGACGAGCTGACCAAGAATCAGGT 
               
               
                   
                   
                 GTCCCTGACCTGCCTGGTCAAGGGCTTCTACCCTTCCGATATCGCCGTGGAATGGG 
               
               
                   
                   
                 AGAGCAATGGCCAGCCAGAGAACAACTACAAGACAACCCCTCCTGTGCTGGACAGC 
               
               
                   
                   
                 GACGGCTCATTCTTCCTGTACTCCAAGCTGACTGTGGACAAGAGCCGGTGGCAGCA 
               
               
                   
                   
                 GGGCAATGTGTTCAGCTGTAGCGTGATGCACGAGGCCCTGCACAACCACTACACAC 
               
               
                   
                   
                 AGAAGTCCCTGTCTCTGAGCCCCGGAAAAGGTGGCGGTGGCTCTTACCCTTACGAC 
               
               
                   
                   
                 GTGCCAGATTACGCCGGCTATCCCTACGATGTGCCTGACTATGCTGGCTACCCCTAT 
               
               
                   
                   
                 GACGTCCCCGACTACGCTTAACTAGCTACGGAATTCCGGCTAGCTGGCCAGACATG 
               
               
                   
                   
                 ATAAGATACATTGATGAGTTTGGACAAACCACAACTAGAATGCAGTGAAAAAAATGCT 
               
               
                   
                   
                 TTATTTGTGAAATTTGTGATGCTATTGCTTTATTTGTAACCATTATAAGCTGCAATAAA 
               
               
                   
                   
                 CAAGTTAACAACAACAATTGCATTCATTTTATGTTTCAGGTTCAGGGGGAGGTGTGG 
               
               
                   
                   
                 GAGGTTTTTTAAAGCAAGTAAAACCTCTACAAATGTGGTATGGAAATGTTAATTAACT 
               
               
                   
                   
                 AGCCATGACCAAAATCCCTTAACGTGAGTTTTCGTTCCACTGAGCGTCAGACCCCGT 
               
               
                   
                   
                 AGAAAAGATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTG 
               
               
                   
                   
                 CAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCA 
               
               
                   
                   
                 ACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTTCTT 
               
               
                   
                   
                 CTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATAC 
               
               
                   
                   
                 CTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTT 
               
               
                   
                   
                 ACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAA 
               
               
                   
                   
                 CGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGAG 
               
               
                   
                   
                 ATACCTACAGCGTGAGCTATGAGAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGG 
               
               
                   
                   
                 ACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCC 
               
               
                   
                   
                 AGGGGGAAACGCCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGACTTGA 
               
               
                   
                   
                 GCGTCGATTTTTGTGATGCTCGTCAGGGGGGCGGAGCCTATGGAAAAACGCCAGCA 
               
               
                   
                   
                 ACGCGGCCTTTTTACGGTTCCTGGCCTTTTGCTGGCCTTTTGCTCAGGGTTCGAAAT 
               
               
                   
                   
                 CGATAAGCTTGGATCCGGAGAGCTCCCAACGCGTCGGCTAGCTAGTAGGGATAACA 
               
               
                   
                   
                 GGGTAATAAGCGTCGACGGCGCGCCCCTAGGGGCCGGCCTTAATTAAATCAAGCTT 
               
               
                   
                   
                 ATCGATACCGTCGAACCTCGAGGGGGGGCATCACTCCGCCCTAAAACCTACGTCAC 
               
               
                   
                   
                 CCGCCCCGTTCCCACGCCCCGCGCCACGTCACAAACTCCACCCCCTCATTATCATA 
               
               
                   
                   
                 TTGGCTTCAATCCAAAATAAGGTATATTATTGATGATGTTT 
               
               
                   
               
               
                 121 
                 HDAdCD44v6BiTE 
                 AAACATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGGGGGT 
               
               
                   
                   
                 GGAGTTTGTGACGTGGCGCGGGGCGTGGGAACGGGGCGGGTGACGTAGGTTTTAG 
               
               
                   
                   
                 GGCGGAGTAACTTGTATGTGTTGGGAATTGTAGTTTTCTTAAAATGGGAAGTGACGT 
               
               
                   
                   
                 AACGTGGGAAAACGGAAGTGACGATTTGAGGAAGTTGTGGGTTTTTTGGCTTTCGTT 
               
               
                   
                   
                 TCTGGGCGTAGGTTCGCGTGCGGTTTTCTGGGTGTTTTTTGTGGACTTTAACCGTTA 
               
               
                   
                   
                 CGTCATTTTTTAGTCCTATATATACTCGCTCTGCACTTGGCCCTTTTTTACACTGTGAC 
               
               
                   
                   
                 TGATTGAGCTGGTGCCGTGTCGAGTGGTGTTTTTTTAATAGGTTTTCTTTTTTACTGG 
               
               
                   
                   
                 TAGGCGCGCCGTCGACGCTTATTACCCTGTTATCCCTACTAGCTAGCCGACGCGTT 
               
               
                   
                   
                 GGGAGCTCTCCGGATCCAAGCTTATCGATTTCGAACCCAAATGGATCTACCACATTT 
               
               
                   
                   
                 GTAGAGGTTTTACTTGCTTTAAAAAACCTCCCACACCTCCCCCTGAACCTGAAACATA 
               
               
                   
                   
                 AAATGAATGCAATTGTTGTTGTTAACTTGTTTATTGCAGCTTATAATGGTTACAAATAA 
               
               
                   
                   
                 AGCAATAGCATCACAAATTTCACAAATAAAGCAATAGCATCACAAATTTCACAAATAA 
               
               
                   
                   
                 AGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATC 
               
               
                   
                   
                 ATGTCGAGCTAGCTAGTCAGGACTTCAGTTCCAGCTTTGTGCCGGCTCCGAAGGTC 
               
               
                   
                   
                 AGCGGGTTGCTAGACCATTGCTGACAGTAATATGTGGCGGCATCCTCGGCTTCCATA 
               
               
                   
                   
                 GAGCTGATTGTCAGGCTGTAGCTGGTGCCAGATCCAGATCCGCTGAATCTGTAGGG 
               
               
                   
                   
                 CACGCCGGAGGCCACTTTGCTTGTGTCGTAGATCCACCGCTTGGGGCTTGTGCCAG 
               
               
                   
                   
                 ACTTCTGCTGATACCAGTTCATGTAGGACACGCTGCTGCTGGCTCTGCATGTCATGG 
               
               
                   
                   
                 TCACTTTCTCGCCTGGGGAAGCGCTCATGATGGCGGGGCTTTGTGTCAGCTGAATA 
               
               
                   
                   
                 TCGGAGCCACCACCACCGCTTCCACCACCACCTGAACCGCCTCCGCCACTAGAAAC 
               
               
                   
                   
                 TGTCAGGGTTGTGCCCTGGCCCCAGTAATCCAGACAGTAGTGGTCGTCGTAGTACC 
               
               
                   
                   
                 GGGCACAATAGTACACAGCGCTATCTTCAGAGGTCAGGCTGGACAGCTGCATGTAG 
               
               
                   
                   
                 GCGGTAGAGCTGCTCTTGTCGGTGGTCAGTGTGGCCTTGTCCTTGAACTTCTGGTT 
               
               
                   
                   
                 GTAATTGGTGTAGCCCCGGCTGGGGTTGATGTAGCCGATCCATTCCAGTCCTTGGC 
               
               
                   
                   
                 CAGGCCTCTGCTTGACCCAGTGCATGGTGTACCGGGTGAATGTGTAGCCGCTGGTC 
               
               
                   
                   
                 TTGCAGGACATCTTCACAGAGGCGCCAGGTCTAGCCAGTTCGGCGCCAGACTGTTG 
               
               
                   
                   
                 CAGCTTGATATCGGATCCGCCACCTCCGCCAGATGACACTGTGACCAGTGTTCCTCT 
               
               
                   
                   
                 GCCCCAGTAGTCGAGGCCCTGTCTGGCGCAATAATACACGGCGGTGTCCTCGGCTC 
               
               
                   
                   
                 TCAGGGAGTTCATCTGCAGGTACAGGCTGTTCTTGGCGTTGTCCCGGCTGATGGTG 
               
               
                   
                   
                 AATCTGCCCTTGATGCTGTCCAGGTAGTAGGTGTAGCTGCCGCCGCTGCTGATTGT 
               
               
                   
                   
                 GGACACCCATTCAAGGCCTTTGCCAGGAGCCTGTCGGACCCAGCTCATATCGTAGC 
               
               
                   
                   
                 TGCTGAAGGTGAAGCCGGAAGCGGCACAGCTCAGTCTCAGAGAGCCGCCAGGTTT 
               
               
                   
                   
                 CACAAGTCCGCCGCCTGATTCCACCAGCTGCACTTCAGATCCACCACCGCCACTAC 
               
               
                   
                   
                 CTCCGCCTCCGCTTCCTCCGCCGCCAGATCCTCCGCCACCTCTCTTGATTTCCACCT 
               
               
                   
                   
                 TGGTGCCTCCGCCAAATGTCAGGGGATTGCTGGACCACTGCAGGCAGTAGTACACG 
               
               
                   
                   
                 GCGAAGTCCTCAGGTTCCAGGCTGCTTATGGTCAGGGTGAAATCGGTGCCGCTGCC 
               
               
                   
                   
                 AGAGCCAGAAAATCTGGCAGGCACTCCGCTGGCCAGATTGCTGGTCAGGTAGATCA 
               
               
                   
                   
                 GGATTCTAGGGGCCTGTCCGGGCTTCTGCTGCAGCCAGTAGATGTAGTTGATGGAG 
               
               
                   
                   
                 CTGCTGGCGCTACAGCTCAGGGTAGCTCTCTCGCCAGGGCTCAGAGACAGTGTGG 
               
               
                   
                   
                 CTGGAGACTGTGTCAGCACGATCTCGCCGGTGGTATCAGGCAGCCAAAGCAGCAGC 
               
               
                   
                   
                 AGGAACAGCAGCTGAGCAGGGGCTTCCATGGTGGCCCTCCTTCGCCGGTGATCTCA 
               
               
                   
                   
                 GCTGTAGGAAAGAGAAGAAGGTTAGTAGTCGACGTGTCCCTCTCGATGAATCTAAGT 
               
               
                   
                   
                 ATCAATTGTGAGCGCTCACAAGTCAACACTCTTTTTGATAAATCTAGTAGATATCACT 
               
               
                   
                   
                 TACGTAGGCGCCGGTCACAGCTTGGATCTGTAACGGCGCAGAACAGAAAACGAAAC 
               
               
                   
                   
                 AAAGACGTAGAGTTGAGCAAGCAGGGTCAGGCAAAGCGTGGAGAGCCGGCTGAGT 
               
               
                   
                   
                 CTAGGTAGGCTCCAAGGGAGCGCCGGACAAAGGCCCGGTCTCGACCTGAGCTTTAA 
               
               
                   
                   
                 ACTTACCTAGACGGCGGACGCAGTTCAGGAGGCACCACAGGCGGGAGGCGGCAGA 
               
               
                   
                   
                 ACGCGACTCAACCGGCGTGGATGGCGGCCTCAGGTAGGGCGGCGGGCGCGTGAA 
               
               
                   
                   
                 GGAGAGATGCGAGCCCCTCGAAGCTTCAGCTGTGTTCTGGCGGCAAACCCGTTGCG 
               
               
                   
                   
                 AAAAAGAACGTTCACGGCGACTACTGCACTTATATACGGTTCTCCCCCACCCTCGGG 
               
               
                   
                   
                 AAAAAGGCGGAGCCAGTACACGACATCACTTTCCCAGTTTACCCCGCGCCACCTTCT 
               
               
                   
                   
                 CTAGGCACCGGTTCAATTGCCGACCCCTCCCCCCAACTTCTCGGGGACTGTGGGCG 
               
               
                   
                   
                 ATGTGCGCTCTGCCCACTGACGGGCACCGGAGCGATCGCAGATCCTTCGATAGAGA 
               
               
                   
                   
                 AATGTTCTGGCACCTGCACTTGCACTGGGGACAGCCTATTTTGCTAGTTTGTTTTGTT 
               
               
                   
                   
                 TCGTTTTGTTTTGATGGAGAGCGTATGTTAGTTACGATTCACACAAAAAACCAACACA 
               
               
                   
                   
                 CAGATGTAATGAAAATAAAGATATTTTATTGCGGCCGCTCGAGTCTAGAGGACATGC 
               
               
                   
                   
                 CATGGTCGTATTACCCTGTTATCCCTAACTGCATGCGACGTCGGCGCGCCATCGAAT 
               
               
                   
                   
                 TCCTGCAGCCCGGGGGATCCCTTTGTTGATTTTTTCCACATAGATTATTTTTGACTGT 
               
               
                   
                   
                 TTTGGCACTTTATATAAATGGAATCATATAGTAAATATATACATGTATATATGTATATAT 
               
               
                   
                   
                 ACACTATATATGTATATATATAGTGTATATATATACATGTATATATGTATATTTACATAT 
               
               
                   
                   
                 ATACTGTATATATGTATATTTACATATATACTGTATATATGTATATATACACGTATATAC 
               
               
                   
                   
                 TGTATATATACAGTATATACTGTATATATATACTGTATATATGTGTATATATATATACAG 
               
               
                   
                   
                 TATATATACAGTATACATATATATACATGTATATATACACAGTATATATACATGTATATA 
               
               
                   
                   
                 TACACAGTATATATACATGTATATATACACAGTATATATACATGTATATATACACAGTA 
               
               
                   
                   
                 TATATACACTGTATATATGTATATATATACTGTGTATATATATACAGTATATATACAGTA 
               
               
                   
                   
                 TATATATACATGTATATGTATATATATACTGTATATATGTGTATATATACGTATATATAC 
               
               
                   
                   
                 TGTATATATATATAGACACTTTTGTGTCTGGCTTCTTGCTCTCATCATAAAGCACTTGA 
               
               
                   
                   
                 AATCCATCCATGTTGTAGCTGGTATCAGTAGCTAGTTTCTTTTCATTGCTGAGAAGTA 
               
               
                   
                   
                 TCACTTTTTATTGATGAGTAGTTTTACATTGTATGAACATGCCCGAGTTTGTTTATGCA 
               
               
                   
                   
                 TTCTACTAATAGACACCTGGGCTGTTTGCAGTTTTTGGCTATTACAAAGAAAATTTCT 
               
               
                   
                   
                 ATATTTTTTTCCAACTTTTATTTTAGGTTCAGCGGGTACATGGGCAGGTTTGTTACATC 
               
               
                   
                   
                 GGTAAATTGCATGTCACTGGGGTTTGGTGTACAGATTATTTCACCACCCAGGTAATA 
               
               
                   
                   
                 AGCATAGTACCTGATAGGCAGGTTTTTGATCCTCACCCTCCTCCCTCAAGTAGGCCC 
               
               
                   
                   
                 CAGTGTCTATTGTTCTATTCCTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTTGCC 
               
               
                   
                   
                 CAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGGTCCACCTCCAGGGTT 
               
               
                   
                   
                 CAAGCGATTCTACTGCCGCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCACCAC 
               
               
                   
                   
                 CACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCCAG 
               
               
                   
                   
                 GATGGTCTCGAACTCCTCACCTCAGGTGATCCGCCCGCTTCGGCCTCGCAAAGTAC 
               
               
                   
                   
                 TGGGATTACAGGCGTGAGCCACGGTGCCTGGCCTATGGTTCCATTCTTTGTGTACAC 
               
               
                   
                   
                 GTGTACTCAGTGTTTAGCTTCCACTTGTAAGTGAAAACATGCAGTATTTGGTTTTCTG 
               
               
                   
                   
                 AAATTCTTGTCTTCATCTTTTTGTAGACAATCCACTACTTTTATTTTTAAATATTAGGAA 
               
               
                   
                   
                 CAATAGCCTCTGTGTGTCCTGAATTGCAATGTTTTTTCTCTGATTTTGCTGCTCATCTT 
               
               
                   
                   
                 GTAACCTGTATGGTGTTTTTCTGTGTGCAAGCTTTTTACTTTACGTGGGCAATTTTAT 
               
               
                   
                   
                 CATTCTTTTCTTTTATGGTTTCTGGGTTTCATGTCATGATTGGAGAAGCTTGATCTACC 
               
               
                   
                   
                 CTGATACTATAAAAATATCCACCTTGGCTTTTTTTTTTTTTTTTAGATGGATTTTCACTC 
               
               
                   
                   
                 TTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACCACAACCTCTGCCT 
               
               
                   
                   
                 CCCAGGTTCAAGTGATTCTCCTGCCTCGGCCTCCTGAGTAGCTGGGATTACAGGCA 
               
               
                   
                   
                 TGCGCCACCACGCTCAGCTAATTTTGTATTTTTAGTAGAGACAGGATTTCACCATGTT 
               
               
                   
                   
                 GGTCAGGCTGGTCTTGAACTCCCCACCTCAGGTGATCTGTCTGCCTCGGCCTCCCA 
               
               
                   
                   
                 AAGTGCTGGGATTACAGGCGTGACCCACCACACCTGGCCCACGTTGTTTTCTGATA 
               
               
                   
                   
                 GTGTTTTCACGTGTTATTTTTTCTGTCTTACTCTTTGAATCATCTAAATGTATCTTAATG 
               
               
                   
                   
                 TCAGGAGTGAGGTAGAGGACCCAGTTGTTTGGTTTAAATGACTAGCCAGTTTTCCCA 
               
               
                   
                   
                 ACACCAGGTGTTGAACATCCCTCACTGATGTGAGATGCTGCCTTTTTCACAGTCTCA 
               
               
                   
                   
                 ATCCCCATGTGCATTTCTATTTATTTTCCTTCCACTTTATTCACATCTTTTTCAGTATCC 
               
               
                   
                   
                 ACAACCATATTGTTTTAAATAGCTTCATGATATGTTTTAATATTTGGTAGAGCTAGAAC 
               
               
                   
                   
                 CCTTTCTTGGTTCTTTTTCTTTTCTTCTTCTCCTCCTTTTCCTCCTCCTTCTTTCTCCTC 
               
               
                   
                   
                 CTCCTTCTTCTTTCTTTTTAGAAATTTCCTGGCTATTCTTGTTTTGTAGTCTTCCAGAT 
               
               
                   
                   
                 AAATAATTTTGAATCACTTTGTCATGTTCCAGAAAATAATACTGCCAGAATTTTTATTG 
               
               
                   
                   
                 TGATCACAGAAGTTTTACAGATTCATCTGGGGGAAAAAAACCCATCTTCCCAGAATAC 
               
               
                   
                   
                 AGAAAGGGTGAGGGAAAGACAAACATCAAGGACAAGTCTCAGGTTCTGGACTTGGA 
               
               
                   
                   
                 GACCAAGAGGATTTGGGGCATCCGGGAGCAGGGCAGGGAGGTGTGATGGCTGCCT 
               
               
                   
                   
                 TTCACTGAGTAGGAGGATGCCCAGACTTGGGGGAACTATGGAAAGTTTGGTTCAGA 
               
               
                   
                   
                 CTTTCTGAGTTGGAGATGTCTATGCGCAGTCCACAGGGCGAAGCCCTGGAGGTAGA 
               
               
                   
                   
                 GGCCCTCCTTACTGCCTCCCTCATTCAGTCTGAGGTCCATTCTCCACATGGACACTG 
               
               
                   
                   
                 AAGTGACTCAAGGCTTCCCTTGTTGGATCAGGATAGTCTCCAGGGCCCTGGGTGGT 
               
               
                   
                   
                 CTGGGCCTGCCCACCTCCCCATCCCCTCTCCTGCCTGCCCTCCTCTTGCTCACTGG 
               
               
                   
                   
                 ACCCCACCCACCAGCCTCCTTCTATTCCTCCTGACATTTGCACTTGCTGTTCCGTCT 
               
               
                   
                   
                 CTGCTTGGAACATCCTAGCTCTTTGCATGGCTTGCTCCTTCCCATCTTTTAATCTAAG 
               
               
                   
                   
                 CTCAAATATCACTCCTTCAGATATGCCTTTCCCAAATATCCTAGCTAAAGAGAACTGC 
               
               
                   
                   
                 TCCCCACTTCCCACAAGCCCTAGCAAACTGGGACTCTCCTTCTTGCTTTCTTTCTCTC 
               
               
                   
                   
                 TGCCCCTTCTGTGTTTTTTCCATAGACCTTAACTTGTTACTGTTTTATTTGTTGATGTG 
               
               
                   
                   
                 TTTACATCATTTGTCCCCCTGTGATGGTTAGTTTTATGTGTCAACTTGGCTAGGCTGT 
               
               
                   
                   
                 AGGGGCTGTTCGTCAATCAAACACTGATCTATGTGTAGCTGTGAAGGGATTTTGTAG 
               
               
                   
                   
                 CTGTGATTAATAGTTGACTTTAAGTAAGGAAGATTATCCTGGAGAATGTGGGGGAAG 
               
               
                   
                   
                 GGGCAGACCTCAGCCAATCAGTTGAAAGGCCTTAAGAACAAAGCTGAGATTTCCCC 
               
               
                   
                   
                 GAGGAAGAAGAAATTCTGCCTGTGGACTGCAGCATCAGCTCCTGCTTGAGAGGTTC 
               
               
                   
                   
                 CAGGCTGCCCTTCCTGACAGCCTGTCCTATGATTTTGGACTTGCCTTGCCAGGTTTT 
               
               
                   
                   
                 TCCTCTTTCTTGACCCCCCAAAACCATATATATCTCCTGCTGGTTTGTTTCTCTGGTG 
               
               
                   
                   
                 TAATCCTGAGGGATGAACACTCCTCCCTCCCAGTTCACTCTGGGAGAGGTTGGGGA 
               
               
                   
                   
                 TCATGTTTGTCTATTTCCCCATGCCTGGCCCATGCGTGTTTATTGAATCACTGAACAA 
               
               
                   
                   
                 CCACGCATTAGGAAGCCAGTCATATGTGCTTCTTCAGAACCTCATGTCCATTGCCAG 
               
               
                   
                   
                 ATCTCCCTGGCTTTTGTGGCTAGAGGACAAGTGAGAGATAGTAGCTTACCCACAGAC 
               
               
                   
                   
                 CTTGGCCCTGAGGCCCCCAGGGGCCTGAGCCTGCTGTAAGGGAGGAGGGAGCCCC 
               
               
                   
                   
                 TGAGGTCTCACACACCTCCCTGGGGATCTGGCATTTTCCCCTGGGGCTGGCCTCAG 
               
               
                   
                   
                 AGCTGGGCGGGGGCAGATTATGGAGTGGGTTGTAGAGGGAGCACCTCCCCACTAG 
               
               
                   
                   
                 CAATCATGGTTTTTTCTGCGCCTCTCATAGGGAGGCCTACAGGCCTCCACCTTCAGC 
               
               
                   
                   
                 TCTTCAGGAGCCACAGGCAGCTGAGTGACTTCTGCATCACAGTCTTCTCAGAGACAA 
               
               
                   
                   
                 ACTTGCAGTAAGAAAGAGGGGCCCGTGAGGGACCCCAGAGAAGGCTGTTGTCAAAG 
               
               
                   
                   
                 CAGGATGAGAGTGAACTCTTCCATGGGGGACACCCAGCGTCTCCAAGCTCTTTTATG 
               
               
                   
                   
                 CTGTCTTCAAGGGGTCTAGAGAGCTTCAGCCCAACATGAGACCCAGTCCAGCAGCA 
               
               
                   
                   
                 TTTCCCTGCGAAGTGAAAGTTAGGACCCTGACTAGATACACCACGCTGACCTCAGCC 
               
               
                   
                   
                 AGAATATCAAGATGCTGAGGCGCTGAGATGCTGGGATGCTAAGGTGCTAAGGTGCT 
               
               
                   
                   
                 GGGGTGCTGGGGTGCTAGGATGCTGAGGTTTTGTGATACTGGGTCGCTGAGATGCT 
               
               
                   
                   
                 GGGATACTGGGGTGCTGAAGTGCTGGGGTACTGGGGTGTTGCCATGCTGAAATGCT 
               
               
                   
                   
                 GGGGTGTTGGGATGCTGAGGTGCTGGGTTGCTGGGATGCTGGGATAGTCCTTGGAT 
               
               
                   
                   
                 GCTGCGGTGCTGAGATGCTGGTCTGCTGGTCTGCTGGGGTGTTGGGATGCTGGGA 
               
               
                   
                   
                 TTTTGGGATGCTGGAGTGCTGCAGTGCTGCAGTGCTGAGATGCTGGAGTGCTGGGG 
               
               
                   
                   
                 TGCTGGAATACTGTAGTACTGGTGTGCTGGAGCATTGAGATGCTAGGGCACTGGGA 
               
               
                   
                   
                 TGCTAAGGTGCTGAGATGCTGCAGTGCTGGGGTGTTGGGATGCCGAGGTGTTGGG 
               
               
                   
                   
                 ATGCTTAAGTGCTGGGGTGTTGGGATGCTGGGGTGCTGGAACACTATGGTGCTGGG 
               
               
                   
                   
                 GTGCTGGAGTGTTGAGATACTGTAGTGGTGGGATGCTTAAGTGCTGGGGTGCTGGG 
               
               
                   
                   
                 TGTTGGGATGCCTAGGTGCTGGGGTGCCGAGATGCTGGAGTACTAGTGTGCTGGGA 
               
               
                   
                   
                 TGCTGAAGTGCTGGGGTCCTGAGATGCTGCAGTGCTAGGGTGCTGAGATTCTGGGC 
               
               
                   
                   
                 TGCTGGAGTGTTGGGGTGCTGGGATGCTGGAGTGCTGAGATGCTTGGACAATGGG 
               
               
                   
                   
                 GTGCTGGAATACTATGGTGCTGGGGTGCTGGGGTATTGAGATGCTAGGGTACTGGG 
               
               
                   
                   
                 ATGCTGAAGTGCTGAGATCCTGGAGTGCTGGGCTGCTGGGCCACAGGCTCTTGAAT 
               
               
                   
                   
                 CCATTCGTCTGCCCAGGGGAAGAAACCAGAAGATAAAGAGCTAATGAAGGAGCTTT 
               
               
                   
                   
                 GGTTGAGAGGGAGGAAGTAATGGAAGGAGCAACATCTTGTGGAGGAGCAGGAGAG 
               
               
                   
                   
                 AATGGACCTCAGGTTGGGAGAGAGGGCCAGGCTACAGGCCAGAGAGGCAGAAGGA 
               
               
                   
                   
                 TTCCAGCAGAGTGTGGGCTCCAGGAGCCAAGGGGAAACAGGTTTCTGGGAGGAGA 
               
               
                   
                   
                 GAGTCCAGTACTGCTGAAGTGGCAAGTCCGCTGAGGACCAGGAAGCTTCATTTGGC 
               
               
                   
                   
                 TTTATGACCAGGAGGAATTTGGAACTGTGACTAGAGTACTTAGGGGGAAGGAGGCA 
               
               
                   
                   
                 AGACTGGAGCCAGATTGCTCTGGGTTGAGGGGTGAGTGGGAGGTGAAGCAGGGCA 
               
               
                   
                   
                 CTGTCACTCCTTTGAAGGGTGGCAGAGAGCTGGAATTGGTGCTGGATGGGCTGTGG 
               
               
                   
                   
                 GGTGACAGGGTCATGTGGAAAGCCCCTGGGGGGCACCTGGAAAAGGAGAAGCTGA 
               
               
                   
                   
                 CAGTACAGTGAGAGGACAGCTAAGGGAAAGCGGAATGGCAGAACACGCACTGCCA 
               
               
                   
                   
                 GGAGGAATGAGGATAGGGTCAGGAGTGCCAGGGGCAGTGAGGCCAGCCTGGGGT 
               
               
                   
                   
                 CAGGTGGCAGGACGTGTCCAGGAAGCTGGTCTGCACTGCAGCCCACACTGGCTCA 
               
               
                   
                   
                 GCCTTGAGGTTCCCTGTGTGGTTGGGGTAGGAAGTTGAACCCTCTGGGAATGGAAG 
               
               
                   
                   
                 ATGGAACCAGCTCTGCGAGCCAAGCTCAGCTTTTATCTATGGGTCTCTGAGGGCTG 
               
               
                   
                   
                 GCAGAGCTGAGTGGGGACAACTGTGATCCGTGAGGCTCTCAGGTTGAGGTGGCCC 
               
               
                   
                   
                 CTCCGGGAGGGCTTCATTTTCCCAGCGGGTAGGTTCTAAGCAGCAGTGGCTGGGCA 
               
               
                   
                   
                 GGTGGGTCCAACACAGAGCCAGAGAAGGGTGAATGGGCCTCCTGGCACCCCACCC 
               
               
                   
                   
                 CTGCTGCCCCTGAGCTCAGTGATGGAGGGGGACAGCACAGCTGAGCCCAAGTGCT 
               
               
                   
                   
                 TTGGTGTGGCCCTGAGGGAAAGCTGCAGCCTGCCTGGGGCCTGGCATGGATGGGA 
               
               
                   
                   
                 CACTTGAGGCAGAGGGACAATAGTGGGCGCTGCAGTGAGGCTGGCTCTTGGAGAG 
               
               
                   
                   
                 GTTTCCTGAGGAGTGCTGCCTGAGACGGGCAGGGAGAACAGAGACAAAGTTGGTGA 
               
               
                   
                   
                 CAGGGAATGAAAGCTGACTGAAGGACTTTACCCAGACCTATGAGGATATCTCTCTCA 
               
               
                   
                   
                 GCAGGAAGCAGGAGGGGACTGTGTGAGGACTGGCCAAGAGCTGGAGTGTTGGGAA 
               
               
                   
                   
                 AATGACTCTTTCTCCGACCCCTCTGTCCTAGCTCTGGCCCCTGGACTGCGGAGGTCT 
               
               
                   
                   
                 GCTTCCACCCCCATTGGTCGATCGTTGTCCCTTGTCACAGCCATTGAGAATTTTGGC 
               
               
                   
                   
                 AGGGAGCATGTTCTTAGAGCATTTTTAGGCTCTGCGGGACATAACAGCTCTGCCTCA 
               
               
                   
                   
                 GAGCACATGCCTTTCTCAGCTCCTGAAAGCCACTGATCAAATTGGAACATTTTGTAC 
               
               
                   
                   
                 CTTAGGGATGAGGATATCAACTCTCCCAGCCACTTAGAGGGATAAATGTGATGATGC 
               
               
                   
                   
                 ATTCAATTGTGACTACATCTGATCCCAACTGTTGCTTCAGCTGCTCTCCTATAGCACA 
               
               
                   
                   
                 TGGCGGGAGGCGTGCATCCCAGTAGCTACCTCCCCACTTTTGGGGAGATGTGGTTC 
               
               
                   
                   
                 CATCCATGAAACCTGGGTACCCGCCTACCAGGTCCTGGCCTATCAGGTGGCAGGGT 
               
               
                   
                   
                 CTGGTCAAAGAAGGGCATGTGTGGTCTTCAGCAAGGGAGACAGGACGGTGGTGCA 
               
               
                   
                   
                 GAGCGTCTAGACCCTCAGGGCAAGTCTCCCCCACACCTGCTCCCGGGGCAGTTGTC 
               
               
                   
                   
                 TTTGTGACCTCCCATCCCCCTCTGTTTCATCCTCTATAAAATGAGGGGCTGAGCCCC 
               
               
                   
                   
                 AAAATAACAGGCTTCTTTGCCATGATGCAAAACTGCTGAATCTTTCTTTCTGACACAC 
               
               
                   
                   
                 AAGGCATCGAGCAGCCTCTGAAAGAACCAAAGCCACTAGCAGGCTTCCTGACTTGG 
               
               
                   
                   
                 GTTTGTAGGTACTGAATACTCCCTTGAAAAATAAAAACATAGAGGCACTTTTCTCCTG 
               
               
                   
                   
                 GCTGTTTATTACAGAACGAAGAAAAAACACACTGGCTTGAAACAGACGCCAGATTTC 
               
               
                   
                   
                 AAATGTAGAGGTGAAATACGAGGTGGCAATTAAAATGTGATTACAGAAAGTCTGGAC 
               
               
                   
                   
                 ACTGAGAAAAGTTTACAGGACAGTGGGTGTGGGTTTTCTATAACAGACACTTAAATAT 
               
               
                   
                   
                 ACATGACGATAATTGCAGATAGAAACCATCAAAGACAAACCCCAAATCAACTAATAAT 
               
               
                   
                   
                 GTTTACAGATGTTCCCCCCCAAACCACAGAGCCTTACATCAAAACAAATACTGAAAG 
               
               
                   
                   
                 GCTTTAAACCAGGAACAGCTCGCCTTAACCCCACGAGGGTGCACACAAGCTGGGCT 
               
               
                   
                   
                 TTTTCTCTCGGTCTGAATGGTAAAGGGAGGAGGATACTCTAGCTCCTCCAGGTGGAT 
               
               
                   
                   
                 TGCTGAGACAGGGCTCGGCTCACACACTGTCTCTGCGCCTCTCCCAAATCTGGAGA 
               
               
                   
                   
                 ACTCTCCCAGCCTCCTGGTAAAGTGTCTCTGTGGGGCACTTAACGATAAAACAGCTT 
               
               
                   
                   
                 CTGCTGTAAAGCTCATTAGGAAAGAGCTAGCGGAGACTGAAAGGTTCGCAAAAGAG 
               
               
                   
                   
                 ATTAAGAATCACACAAGGCAATAGGATTTTTAGTGAACATAGAAATAAATGGCCAAGT 
               
               
                   
                   
                 GGTTTTCTATTTGGCATTTGTCAACTTGCACAACAACTCTTGGTCATATCCACATTGC 
               
               
                   
                   
                 TCATTGCATTAAAACCATAAGCGACTCAGCCACCTAGCTTAACAAGGTATCACTGGA 
               
               
                   
                   
                 GCAAACAACACGGTCTGCATATTTGTAACATTGTATAATAAACACAAAACAATGCATA 
               
               
                   
                   
                 GTAAACACAACTCTACTGAAACAAAAGCCGTCGCTTTATTTACAAAGTCACAAAATGA 
               
               
                   
                   
                 AGTATAAATACTTCTGTCATTAATGTTTAGGAAAACCATTTACAAAATTTTCAAATATG 
               
               
                   
                   
                 TACACGTAGCTTGAAAAATCACCAGCTTTCCATTTTGTCACAGGTAGAGAGAGGGAT 
               
               
                   
                   
                 AAGCATGGGCTGACAACACCACTCAAATTGTAACGGGAGACAACTGCGGGTATGGA 
               
               
                   
                   
                 TCGACACCACTTCCTAGAGTGATGTCACCATGGGGGTTTCTATGGGCATCCTGCTCA 
               
               
                   
                   
                 GATTTAAAGTGCCCCAGCATCCTGGGTGACTTGCCCAGAATTCTGGGCTGTGGCATT 
               
               
                   
                   
                 TTGAGCAGCAGCATGCTGTTCCAAAATGTCGTCGATCAGCCTCAAGTTGCACACCCA 
               
               
                   
                   
                 GTCTTCATCTGGGCTCACACAGGAGCCTTTCAAGAGAGCTTCAATGAAATCTACCTC 
               
               
                   
                   
                 ATTGCAGTCAGGTGACGAAATCAGATCATTTAGTGGGGGTTGGGGCTGGCGCAAAA 
               
               
                   
                   
                 AGTCGGCAGGTGGCAGCTCAGGGGGAATATCCGTTCTGTCGAACGGACCTGGGAA 
               
               
                   
                   
                 CTGGCTGGCAGCAACGGCAGAAGCAGCAGCAGCGGTGGCAGCAGCAGCCACATAG 
               
               
                   
                   
                 CTTGGTGGCTCGATGCCCTGTATGGGGCTCAGGGGACTAAAGCTGGCCATACCCTG 
               
               
                   
                   
                 CTGGAGGAACTTGGTGGTGTTTGCTACAGGCACCGGGCCCTGTACCGGGCTCTGCC 
               
               
                   
                   
                 TGAGGCTCTGGCTGCCCAGCAGGCTGAAGCTGGGGTTGTTGGCCAGGGGCACTTG 
               
               
                   
                   
                 TGTTCCCATCGCAGCGGGCACTTGTGCCTCCCAATCAGATGGCCTCTGAAGGCAGG 
               
               
                   
                   
                 CCTGGCCAGAAGGTGAGTGCTGCTGAACGCTATTATCCACTTGGCTGAGGGGTGTT 
               
               
                   
                   
                 TTCCCCGAAACTGCTGTGGTCACAGCTGCTGCCGCTGTGACCCATGCAGCATTGTT 
               
               
                   
                   
                 GAACGCAGTGGGCATTCTTGGCACACTAGGCCGTCTGAGCTGGTGGGGACTCAAG 
               
               
                   
                   
                 GACTGGGTGCCCAGGGAGCTGGGACAGAACCCAGGCAGGGGCACTTCTGGTGGG 
               
               
                   
                   
                 GTGGCCTTGGGGCTCTGCATATGCTGGCAGACAGAGTCAAGTCTGCCCAGGGGAGT 
               
               
                   
                   
                 CTGGCCTGAGTGTGAGAGGATGGGACACTGGGGGCTGGAGGTGAAAATTCCTTGC 
               
               
                   
                   
                 CGCTTCCCCAGAGTTGGTGAGATCACTCCCATGCCCTCGCAGCTCTGGTGCCTGGT 
               
               
                   
                   
                 GAGTGGGATCATTCCTGGACTCAGATTGTTCTGAAGAAGCCCAGTTCTGGGTGGCAT 
               
               
                   
                   
                 CAAGTGCTTGCTAGATGGGGGGCTTGCCTTGATCCGGCTACACTTGGAGGTGACTT 
               
               
                   
                   
                 GTTCTTGGACGGCTACATACAGAAAGAGAGAAGTGGGGATGAGTTCCAAAGGCATC 
               
               
                   
                   
                 CTCGACTTCGGCTGTGGCCACCGGAGGGTAGCTCCTGGCCCAACACGGACTTCTCA 
               
               
                   
                   
                 CCTCCCGCCCTTGGCTCTCTACTGAGCTCCCCCCTGCTCCCCAATTCCTCGCCATTC 
               
               
                   
                   
                 CCCTCATTTCTCTGCCCTCAGCCTGGACTGCAGTTCTTCTGGGAAGCTGCCCCAACT 
               
               
                   
                   
                 CCCTAGGTCTGTGCTCACCAAGAGCAGATCACACTGGACTGAAATGCCAGCTGATTT 
               
               
                   
                   
                 GTCTCTTCAAGAAAATTGGAAGCTCCTGGAGGTCAGGGTCCATGTCTGCTTTTACAC 
               
               
                   
                   
                 TCAGTGCTCTGTATGCAGGCCTGGCACTGCCCACCCTTTGACAGGTGGTGCATATTT 
               
               
                   
                   
                 TGTAGAAGGAAGGAAGGGGCCAGGTGGGGTGGGCTGGGCTGGTGGCGGGAGCTA 
               
               
                   
                   
                 GCTCAGCCTCTTAGATTCTCTACCCGATGGATGTGACCTGGGACAGCAAGTGAGTGT 
               
               
                   
                   
                 GGTGAGTGAGTGCAGACGGTGCTTTGTTCCCCTCTTGTCTCATAGCCTAGATGGCCT 
               
               
                   
                   
                 CTGAGCCCAGATCTGGGGCTCAGACAACATTTGTTCAACTGAACGGTAATGGGTTTC 
               
               
                   
                   
                 CTTTCTGAAGGCTGAAATCTGGGAGCTGACATTCTGGACTCCCTGAGTTCTGAAGAG 
               
               
                   
                   
                 CCTGGGGATGGAGAGACACGGAGCAGAAGATGGAAGGTAGAGTCCCAGGTGCCTA 
               
               
                   
                   
                 AGATGGGGAATACATCTCCCCTCATTGTCATGAGAGTCCACTCTAGCTGATATCTAC 
               
               
                   
                   
                 TGTGGCCAATATCTACCGGTACTTTTTTGGGGTGGACACTGAGTCATGCAGCAGTCT 
               
               
                   
                   
                 TATGGTTTACCCAAGGTCAGGTAGGGGAGACAGTGCAGTCAGAGCACAAGCCCAGT 
               
               
                   
                   
                 GTGTCTGACCCACCCAAGAATCCATGCTCGTATCTACAAAAATGATTTTTTCTCTTGT 
               
               
                   
                   
                 AATGGTGCCTAGGTTCTTTTATTATCATGGCATGTGTATGTTTTTCAACTAGGTTACAA 
               
               
                   
                   
                 TCTGGCCTTATAAGGTTAACCTCCTGGAGGCCACCAGCCTTCCTGAAACTTGTCTGT 
               
               
                   
                   
                 GCTGTCCCTGCAACTGGAGTGTGCCTGATGTGGCACTCCAGCCTGGACAAGTGGGA 
               
               
                   
                   
                 CACAGACTCCGCTGTTATCAGGCCCAAAGATGTCTTCCATAAGACCAGAAGAGCAAT 
               
               
                   
                   
                 GGTGTAGAGGTGTCATGGGCTACAATAAAGATGCTGACCTCCTGTCTGAGGGCAAG 
               
               
                   
                   
                 CAGCCTCTTCTGGCCCTCAGACAAATGCTGAGTGTTCCCAAGACTACCCTCGGCCT 
               
               
                   
                   
                 GGTCCAATCTCATCCCACTGGTGCGTAAGGGTTGCTGAACTCATGACTTCTTGGCTA 
               
               
                   
                   
                 GCCTGCAACCTCCACGGAGTGGGAACTACATCAGGCATTTTGCTAACTGCTGTATCC 
               
               
                   
                   
                 TAGGCCAATAAATGTTGATCACATTTATAGCTGCCATGGTAGGGTGGGGACCCCTGC 
               
               
                   
                   
                 TATCTATCTGTGGAGGCTCTGGGAGCCCCTGACACAAACTTTCTGAAGCAGAGCCTC 
               
               
                   
                   
                 CCCAACCCCTTTTCCATTCCCTATACCTGACAGATGGCCCAGGAACCCATTAGAAAT 
               
               
                   
                   
                 GGAAGGTCACTGCAGCAGTATGTGAATGTGCGTGTGGGAGAAGGGCAGGATCAGA 
               
               
                   
                   
                 GCCCTGGGGGTGTGGCAGCCCCCAAGTGATTCTAATCCAGATCCTAGGGTTGTTTC 
               
               
                   
                   
                 CCTGTCCCATTGAAATAGCTGCTTTAAGGGGCCTGACTCAGGGAAATCAGTCTCTTG 
               
               
                   
                   
                 AATTAAGTGGTGATTTTGGAGTCATTTAGACCAGGCCTTCAATTGGGATCCACTAGTT 
               
               
                   
                   
                 CTAGAGCGGCCGGGCCCAGGGAACCCCGCAGGCGGGGGCGGCCAGTTTCCCGGG 
               
               
                   
                   
                 TTCGGCTTTACGTCACGCGAGGGCGGCAGGGAGGACGGAATGGCGGGGTTTGGGG 
               
               
                   
                   
                 TGGGTCCCTCCTCGGGGGAGCCCTGGGAAAAGAGGACTGCGTGTGGGAAGAGAAG 
               
               
                   
                   
                 GTGGAAATGGCGTTTTGGTTGACATGTGCCGCCTGCGAGCGTGCTGCGGGGAGGG 
               
               
                   
                   
                 GCCGAGGGCAGATTCGGGAATGATGGCGCGGGGTGGGGGCGTGGGGGCTTTCTC 
               
               
                   
                   
                 GGGAGAGGCCCTTCCCTGGAAGTTTGGGGTGCGATGGTGAGGTTCTCGGGGCACC 
               
               
                   
                   
                 TCTGGAGGGGCCTCGGCACGGAAAGCGACCACCTGGGAGGGCGTGTGGGGACCA 
               
               
                   
                   
                 GGTTTTGCCTTTAGTTTTGCACACACTGTAGTTCATCTTTATGGAGATGCTCATGGCC 
               
               
                   
                   
                 TCATTGAAGCCCCACTACAGCTCTGGTAGCGGTAACCATGCGTATTTGACACACGAA 
               
               
                   
                   
                 GGAACTAGGGAAAAGGCATTAGGTCATTTCAAGCCGAAATTCACATGTGCTAGAATC 
               
               
                   
                   
                 CAGATTCCATGCTGACCGATGCCCCAGGATATAGAAAATGAGAATCTGGTCCTTACC 
               
               
                   
                   
                 TTCAAGAACATTCTTAACCGTAATCAGCCTCTGGTATCTTAGCTCCACCCTCACTGGT 
               
               
                   
                   
                 TTTTTCTTGTTTGTTGAACCGGCCAAGCTGCTGGCCTCCCTCCTCAACCGTTCTGAT 
               
               
                   
                   
                 CATGCTTGCTAAAATAGTCAAAACCCCGGCCAGTTAAATATGCTTTAGCCTGCTTTAT 
               
               
                   
                   
                 TATGATTATTTTTGTTGTTTTGGCAATGACCTGGTTACCTGTTGTTTCTCCCACTAAAA 
               
               
                   
                   
                 CTTTTTAAGGGCAGGAATCACCGCCGTAACTCTAGCACTTAGCACAGTACTTGGCTT 
               
               
                   
                   
                 GTAAGAGGTCCTCGATGATGGTTTGTTGAATGAATACATTAAATAATTAACCACTTGA 
               
               
                   
                   
                 ACCCTAAGAAAGAAGCGATTCTATTTCATATTAGGCATTGTAATGACTTAAGGTAAAG 
               
               
                   
                   
                 AGCAGTGCTATTAACGGAGTCTAACTGGGAATCCAGCTTGTTTGGGCTATTTACTAG 
               
               
                   
                   
                 TTGTGTGGCTGTGGGCAACTTACTTCACCTCTCTGGGCTTAAGTCATTTTATGTATAT 
               
               
                   
                   
                 CTGAGGTGCTGGCTACCTCTTGGAGTTATTGAGAGGATTATAAGACAGTCTATGTGA 
               
               
                   
                   
                 ATCAGCAACCCTTGCATGGCCCCTGGCGGGGAACAGTAATAATAGCCATCATCATGT 
               
               
                   
                   
                 TTACTTACATAGTCCTAATTAGTCTTCAAAACAGCCCTGTAGCAATGGTATGATTATTA 
               
               
                   
                   
                 CCATTTTACAGATGAGGAACCTTTGAAGCCTCAGAGAGGCTAACAGACATACCCTAG 
               
               
                   
                   
                 GTCATACAGTTATTAAGAGAAGGAGCTCTGTCTCGAACCTAGCTCTCTCTCTCTCGA 
               
               
                   
                   
                 GTAATACCAGTTAAAAAATAGGCTACAAATAGGTACTCAAAAAAATGGTAGTGGCTGT 
               
               
                   
                   
                 TGTTTTTATTCAGTTGCTGAGGAAAAAATGTTGATTTTTCATCTCTAAACATCAACTTA 
               
               
                   
                   
                 CTTAATTCTGCCAATTTCTTTTTTTTGAGACAGGGTCTCACTCTGTCACCTAGGATGG 
               
               
                   
                   
                 AGTGCAGTGGCACAATCACTGCTCACTGCAGCCTCGACTTCCCGGGCTCGGGTGAT 
               
               
                   
                   
                 TCTCCCCAGGCTCAGGGGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGGACTACA 
               
               
                   
                   
                 GGTGCGCACCACCATCCCTGGCTAATATTTGTACTTTATTTTATTTATTTATTTATTTA 
               
               
                   
                   
                 TTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCGGGCTGGAGTACAGTGGCATGATCT 
               
               
                   
                   
                 CGGCTCAGTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTACCTCATCCCCCT 
               
               
                   
                   
                 GAGTAGCTGGGATTACAGGCGCCTGCCACCATGCCTGGCTAATTTTTTGTATTTTTA 
               
               
                   
                   
                 ATAGAGACGAGGTTTCACCATGTTGGCCAGGCTACTCTCGAACTCCTGATCTCAGGT 
               
               
                   
                   
                 GATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGC 
               
               
                   
                   
                 CCGGCCTAATATTTGTATTTTTTGTAGAGATGGTGTTTTGCCATGTTGTCCAGGCTGG 
               
               
                   
                   
                 TCTTGAACTCCTGAGCTCAAGCGATCTGCCCGCCTCTGCTTCCCAAAGTGCTGGGAT 
               
               
                   
                   
                 TACAGGCATGAGCCACCGTGCCTGGCCTAGGTAGACGCTTTTAGCTTTGGGGTGTG 
               
               
                   
                   
                 ATGCCTGCCCCAGTATATAGTGAATTTAATTATTGCTAGAGCTGGCTGTTTGTTAGTT 
               
               
                   
                   
                 TTCTTTGAACATAAGATACTCATTGTTTTTAGTTTGCAAATCCCTCTTCCTTTTTAAAAA 
               
               
                   
                   
                 ATTTCTTTCCCTTAAATTGTTTGCATGTTAGCAATAACAAATGCTTAAATGGTGCTATG 
               
               
                   
                   
                 TGCTAGATACTCTTCTAAGCCCTGTTATGTATATTAACTAATTTTTTAAATTACACAAAT 
               
               
                   
                   
                 CAGAGAGGTTAAGTAACTTGCCCAAGATTACCCAACAATACTAGGATTTGAACCTAA 
               
               
                   
                   
                 GTTTGTCTCACCCCAGATTCTGCTCTTAATCTCTAAACTTTTAAGTTAGTAGTGACAAT 
               
               
                   
                   
                 AGTAGGTATTTATTGAATACTTAACTATGTTTTAGGCGTTGAAGTAAATATTTTGCAGG 
               
               
                   
                   
                 CATTATCTAATGTAAACACCCTAAAGTTACATAACAGGTACCCTTTAGGTAAATAAAC 
               
               
                   
                   
                 ACTAGTATGACCTTGGAGGCACAGATAGTTGAAGTAACTTGCCCAATATCACTTACAT 
               
               
                   
                   
                 GAAATTGGCCCTCAAATGTGTCTGATACAACCCATGCTGCTTGTAACTATCGTTTTAA 
               
               
                   
                   
                 ACTGCCAGGGTAAACTTGGACACACTTGAGCTAAGAAAAAGCTTTTAGATTTTTGCAA 
               
               
                   
                   
                 ATTAATGTGAAAGATATGCTTTATGTGGATATAATATCTTCTAAATTTCGGGGATGGTA 
               
               
                   
                   
                 GTCCTAGAAATGTAATCCTGCCCTAGCCGAGCTTACCCTGCCAATAATTTTTTACAGA 
               
               
                   
                   
                 ATTGGTAAAACGGAGCACCTTTTTTTTGTCCTTGGCCACACTGTTATCAACAGGGTGT 
               
               
                   
                   
                 AGATTGACATCAATCTGTAGGTGTAAACCAGAATTACTCTTTGTGACCACCAGGAAAT 
               
               
                   
                   
                 AGAGCAGTTCAGTTCAGGGGTTTCTTTCTGTGAATTTAGCACTGTGACCTGCATACTA 
               
               
                   
                   
                 CAAGTCTACTTTGTTTTCTATCCATTGTTTGTATCTGGGTATTGCAAAAGGTAGGAAA 
               
               
                   
                   
                 AGGACCAACCAGATCAGCAGAGAAGAGTTGCCTTGGAGTTTTCTTTTAGTTTTCTGC 
               
               
                   
                   
                 AGTTCATTAGATAGTAACTAGGCCATGTCATTTTACTCCCTTGTAGTGAAGATATGTT 
               
               
                   
                   
                 GAAGTTGTACTGGTATACTCTTCTACCTTTCTGTAATTTTATATTGTGTAGACTTGATA 
               
               
                   
                   
                 AAATTTATGTGTCAATCACCACCATTAATATCAATATTGAGCCTCAATTCTTATTTTTCT 
               
               
                   
                   
                 GCCCAGTGGCTGCCAAATTACTAACATTTACAATAATTCACTACTACTAAGATAATCT 
               
               
                   
                   
                 ACTAGTTCGATCACATACTTCAAATTGTTATGGAACTACTGTCTTCAGCATTGTGCTT 
               
               
                   
                   
                 CTGATAACTGATAAGTATAATTTTTTTTTTGTCCAGAGTGAACATGTCTATTCTTCCAC 
               
               
                   
                   
                 TGTACACACTAATAAAAGGAAAAATTGTAATATTGGGTAAATTCATGTCCTTACACAT 
               
               
                   
                   
                 GTAGTAGTTATGAGCCCATGTCCCTAGAATGAGTAATAATTTATCCCTCCCTTGGTTG 
               
               
                   
                   
                 AATAGTCAAGAATGCTGATTTTAATTCTTCTAACAGCTTTATCCCTCAGAAGGGAAGG 
               
               
                   
                   
                 CAAGCAAGTTATATATGTAGTTTATTTGTAAGACTGATATGAAATTGGAAGATGAATCT 
               
               
                   
                   
                 ACTATTAGCTTTAATTATTTTTACATTTAGGAATATTGCATCAGTAACTCATAATTTTGG 
               
               
                   
                   
                 TTTTCTGTTATCCTGAGTTAACACAAATTATCCAAGGAGATGGCGGATCATCTGCTTT 
               
               
                   
                   
                 GAGGTGTTTTTTTTTGAGAATTTTAATGTATCTGAATATAAAAGGTAAAAATATGCCAA 
               
               
                   
                   
                 CTAGCAATTTCTGCCCATTCCAGAAGTTTGGAAATATTACTCATTACTAGGAATTAAAT 
               
               
                   
                   
                 AAAATATGGTTTATCTATTGTTATACCTCTTTTAATTCACATAGCTCATTTTTATCTTTT 
               
               
                   
                   
                 ATTTTTGTTTGTTTTTTTTGAGATGGAGTCTTGCTCTGTCACCAGGCAGGAGTGCAGT 
               
               
                   
                   
                 GATGCAAATCTCGGCTCACTCTAGCCACCGACTCCCTGGTTCAAGCGATTCTCCTGC 
               
               
                   
                   
                 CTGAGCCTTCTGAGTAGCTGGGATTACAGGCAGGCACCACCACGCCCAGCTAATTT 
               
               
                   
                   
                 TTGTAGAGACAGGATTTCACCGTGTTGGCCAGGATGGTCTCCATCTCCTGACCTCAT 
               
               
                   
                   
                 GATCTGCCTGCTTCGGCCTCCCAAAGTGCTGGGATTACAGGTGGGAGCCACTACGC 
               
               
                   
                   
                 CTGGCCCACATAGCTCATTTTTAGACTCACTTCCATTAAGTCTTGTTTGGACCCACGA 
               
               
                   
                   
                 ACATTGTCTTTTTTTTTTTAAGATGGAGTTTCACTTTTGTTGCCCAGACTGTAGTGCAA 
               
               
                   
                   
                 TGGTGCAATCTCAGCTCACTGCAATCTCTGCCTCCTGGGTTCTAGCAATTCTCCTGC 
               
               
                   
                   
                 CTCAGCCTCCCGAGTAGCTGGAATTACAGGCGCCCGCCACCACGCCCAGCTAATTT 
               
               
                   
                   
                 TTGTGTTTTTAGTAGAGACGGGGTTTCACCATGTTGGGCAGGCCAGGGGTGATCCG 
               
               
                   
                   
                 CCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCATCTGGCC 
               
               
                   
                   
                 AACATGTCTTTTTTTTTTTTTTCCTTTTTAACCACAAAGAGACTTAAGCAGTCCTTGTC 
               
               
                   
                   
                 ACAGATGATGAATTGATGTTGCAAGTATTGTCTTAGCTTGGATTAATTTTCTTGCTTAC 
               
               
                   
                   
                 TGTAATTTTAGATAATATAGCTTTGTAATTAGAGATTTTATGTGTAAACCACAAAAATG 
               
               
                   
                   
                 TTTACATGAAGGCCATTATTACAGATGTGACGTGCATAATTATTAGTAATTTGTATGTT 
               
               
                   
                   
                 TACATGGGTCAGTCTGGCAAAAAATTATGAAGTTTTAAAAATTAAAAAAAATTATAATG 
               
               
                   
                   
                 CCAGTTTTACTGGAAAGTAAAATTATTTCAGTAATCGATTATAGCAAAAGTATTGATTT 
               
               
                   
                   
                 TCATTCCAGACAAAAGTCAGAATGAAAGGTAATTTCTCAATACTCTTTCAGATTAATAA 
               
               
                   
                   
                 AAGTACCTGTAGCGATTTTTATCATTCACAAGTATATCACAAGTAAGTTAGAATTTGA 
               
               
                   
                   
                 GAACTGTGTTCTAGATCTCTGAGGAGATGCAGTCAGATTTCTGAACTGTCTCAGCAA 
               
               
                   
                   
                 ATGGTAAGTAACTTAGAGCTAGTAATTAATAACCTGTCCTTTGATTTCTGATTCAGCC 
               
               
                   
                   
                 AAGAATGGCCATATTTGGGAAAGGCAGATCTGGAGAGTAACCACGTTTTCATTCATT 
               
               
                   
                   
                 TACCACTTCTAGGCCCCTCCAGAGCTCTCAGATATTTTGGGGTTGAGCCCTTCCCCA 
               
               
                   
                   
                 AAGCCATACAGGACCTTTTTTTTGTGATCTGTTCTAGCCATTTTTATGTTGGGTGCTT 
               
               
                   
                   
                 GTTATGGACTGAGCATTTATGTCCTCCCACACCCCCCCCATACCTTTTTTGAAGTCCT 
               
               
                   
                   
                 AACCCCCAGTGTGATGGTATTTGGAGACAGGGCCTTTGGAAGGTAATTACAGTTAGA 
               
               
                   
                   
                 AGAAGTCGGGAGGGTTGGGCCCAGGTCTGATTGGATTAGTGCCCTTATATGAAAAG 
               
               
                   
                   
                 ACACCAGGACGGGCGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAA 
               
               
                   
                   
                 GGTGGGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGGCCAATGTAGTGAAAC 
               
               
                   
                   
                 ACCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTAGCGGGCTCCTGTCATC 
               
               
                   
                   
                 CAAGCTACTCGGGAGGGTGAGGCATGAGAATCACTTGAACCCGGGAGTTGGAGGTT 
               
               
                   
                   
                 GCAGTGAGCCCAGATTGTGCCACTGTACTCCAGCCTGGGTGACAGAGTGAGACTCT 
               
               
                   
                   
                 GTCTCAAAAAAGAAAAAAAAAAAAAAAGAGACACCAGAGAGCTTGTTAGAAGAGGTC 
               
               
                   
                   
                 ATGTGAGCACACAGTTAGAAGACCTTCAAGCCAAAGAAGAGGCCTGAGATTGAAACC 
               
               
                   
                   
                 TACCTTGCAGGTACCTTAATTTTGGACTTCCCAGCCTCCAAAACTGTGAGAAATAAGT 
               
               
                   
                   
                 TTCTGTTAAGTCACTCAGTCTGTGGTATTTTGTTATGGCAGCCTGAGCAGGTAGTTGT 
               
               
                   
                   
                 TCTTTCAGAAGGTGTTGATAATAACCACATGCAACACCAAGTCACAAATAATAAAACA 
               
               
                   
                   
                 GATGTAACTTATATTCATACAGAAAGTTGGGCACTGCCATTGCCTTGTTGGTTTACAC 
               
               
                   
                   
                 GGCTGTGCTAGTTCAGTAGCAGAAAGGTGCTGGTCTCCTTTACTCAGTTTACAATCT 
               
               
                   
                   
                 AGGCAGTAGAATGTAATCACTGCTTTAAACTTGATACTGCTTAGGGAGAGAATCATTG 
               
               
                   
                   
                 GTGCTGGGTAACTTTGGGTTCTAGGTTTACTTTTTGTGTATATATAACTGTTTTTGGTA 
               
               
                   
                   
                 AATCACAAGTTTCTGGGCTTGTCGAATTAGATTTTGTTACAGATTATGAGCTTTATTAT 
               
               
                   
                   
                 GCTATACAGTTAGTTGTATGTATATATGCCTTTCCCACTAGATTTTAAGCTTTTTTTTTT 
               
               
                   
                   
                 TTTTTTTTTTTGTGACGGAGTCTTGCTCTTGTCGCCCAGGCTGAAGTGGAGTGCAGT 
               
               
                   
                   
                 GGCACAATCTCGGCTCACTGCAGCCTCCACCTCCTAGGTTCAAGCGATTCTCCTGC 
               
               
                   
                   
                 CTCGGCCTCCCAAGTAACTGGGACTACAGGCACGTGCCACCACACCCGGCTAATTT 
               
               
                   
                   
                 TTGTATTTTTTGTAGAGACAGGGTTTCGCCATGTTGGCTAGGCTGGTCTTGAACTTCT 
               
               
                   
                   
                 GGCCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTTACAGGCATG 
               
               
                   
                   
                 AGCCACCACGCCCAGCTATAGCTCTTTAAGGGTTGTAAATTTATAATCATTCTTTTAC 
               
               
                   
                   
                 TCTCCTGCAAATTCTGTTGCACACTGCCTTAATCAAGGTAGATGCTGAATGCATTTTT 
               
               
                   
                   
                 GTATAATTGAATATGTTGCAATCCCCAACTCTCTCCAACTGTTCCTGTCAAAGCAGCC 
               
               
                   
                   
                 ACTGGATTGTTAACTAATCCATATTAGATGGGGTTAATTAATATCAGATGGGACAAGT 
               
               
                   
                   
                 AAGGGCTAATAAGATTATAGGCCACCAAGTAGATTTCTGTCTAGCTCTTATAGAGATT 
               
               
                   
                   
                 GAGTTTATTGGACCTGTTTGATAGGAAGTTTTGGTGTTTGGGATGATTAAAACTGAAG 
               
               
                   
                   
                 TTCCTATTTATTGAATTATACCTATTTATATTATTTCATATCAGTGGTCCACATGCAAGT 
               
               
                   
                   
                 GAGGCTTCTGAGACAGAGTTTGAGTTCTCTCTTCAACTACCATAACACTTAACCTGTA 
               
               
                   
                   
                 TCTTTTTTTTTTTTTTTTTTTTTAGACAGGAGTCTCGCTCTGTCACTCAGGCTGGAGTG 
               
               
                   
                   
                 TAGTGGTATGATCTCGGCTCACTGTAACCTCTGCCTCCTGGATTCAAGCAGTTCTCC 
               
               
                   
                   
                 ATGTCTCAGCCTCCCTAGTAGCTGGGATTACAGGCCTGTGCCACCATGCCTGGCTA 
               
               
                   
                   
                 ATTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTTACCACGTTGGCCAGGCTGGTCT 
               
               
                   
                   
                 CGAACTCTTGACCTCGAGCGATCAACTTGCCTTGGCCTCCCAAAGTGCTGGGATTAC 
               
               
                   
                   
                 AGGCATGAGCCACAGCGCCCAGCCGTCTTTTTTTTTAAATAGCAATTTAACACTGTTC 
               
               
                   
                   
                 ACAGTTACTCATGTACATGTCATGCCATCTATTACACTGTAAGTTCTGTGAGGGTAGC 
               
               
                   
                   
                 TGTATCAAATTTATCTAACTCTCTCTAGTATGCATGACATAGTAAGTATTCAATAAATA 
               
               
                   
                   
                 TTTGCATATTAGTGATAAGGATACAGGTTCTGAATAGTGGGTCCTTACCATTTAAGAA 
               
               
                   
                   
                 TTAGTATTTGATGGCCGGGCGGGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA 
               
               
                   
                   
                 GGCTGAGGCGGGCGGATCATGAGATCAGGAGATCGAGACCATCCTGGCTAACATG 
               
               
                   
                   
                 GTGAAATCCCGTCTTTACAAAAAAAATACAAAAGAATTAACCAAGTGTGGTGGTGGG 
               
               
                   
                   
                 TGCCTGTAGTCCCAGCTACTGCTTTGTGAGGCTGAGGCAGGCAGATCACCTGAGGT 
               
               
                   
                   
                 GGGAAATTCAAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATAC 
               
               
                   
                   
                 AAAATTAGCCGGGCGTGGTGGCGCATGTCTGTAATCCCAGCTACTCGGGAGGCTGA 
               
               
                   
                   
                 GGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAGGATCGC 
               
               
                   
                   
                 GCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAA 
               
               
                   
                   
                 AAAAAAAAATTAGTATTTGATATTTGATCATTAAATATGAATTAAGAGGACTTAGACTT 
               
               
                   
                   
                 TTTGTTAAATGTCAAGCTGGGAAAAGTTGTCATTTAAATGAATTGCCTCTTATTTAATT 
               
               
                   
                   
                 TCGTCTGATGATACATTTTGTTTTTATTTTGTAAAAAATTATTTTTTTTCTTTTTGGAGA 
               
               
                   
                   
                 CAGGGTCTTGCTCTGTTGCCCAGGCTGGTCACAAACTCCTGACCTCAAGCAATCCTC 
               
               
                   
                   
                 CTGCCTTAGCCTCCCAAAATGCTGGGATTACAGGCGTGACGACCTCGCCCGGCCTT 
               
               
                   
                   
                 GTATTATGATACATTTTGAACAACTACAAGTAGACTTGGTATAATGAACCTGCACGTA 
               
               
                   
                   
                 CCCATTGCCAAGTTCTGACAACTGTCTGTCTATAGCCAATTATGCATTTCTTAAATTA 
               
               
                   
                   
                 GAACCCCCCCAATATACCCAAATATATATATATGTGTGCATATATATAGTAAGTTGTAA 
               
               
                   
                   
                 CAAAGTTGTGAATTCATACCTGAAGTATCTCAAGTGATGCAAGTTTTATGAATTTTTGT 
               
               
                   
                   
                 TTATGCCTTTTGGGAAGAGTTGTATTGACAAATTTTTTATGCTTAAAGTAAACCATAAA 
               
               
                   
                   
                 TCAAAAAAATAAAATCTAGGATGCAATAAAACAAAACAACTTCTTGACATAAGTATGG 
               
               
                   
                   
                 TATGTAAATCTGTTTTGATTGGAAATCAATTTGTTATATTGCCAGAATTCCTGTTTTAG 
               
               
                   
                   
                 AATACATCTCTGCTGATCTGTCTGTATTCTTAGACTGCATATCTGGGATGAACTCTGG 
               
               
                   
                   
                 GCAGAATTCACATGGGCTTCCTTTGAAATAAACAAGACTTTTCAAATTCTTAGTCGAT 
               
               
                   
                   
                 CTGCAGAACCTGTAGCCAGGCACTGAACCATTTTGATAGATGCAGTAATCGTTGCAA 
               
               
                   
                   
                 GTGTATATTTCAAGGGAGTTCTGGCTGGGTCCTAGTTTATGCTTGTGGCAGAAGCAG 
               
               
                   
                   
                 TGAGTAACTGGGAGGAAGTTGGTGAGTAAGCTTCAAGGAAGAAGTCATTTTTAGTAC 
               
               
                   
                   
                 TCTGGATCTTCCTGATTTTAAAGCACTACAAAATGGTGCATTTTCATTCTTGTCAAGT 
               
               
                   
                   
                 GATAACAGATATATTCTGATGAGCCTGAAATGAATATATATTGTATCATTTTTATAATA 
               
               
                   
                   
                 TCTAGCAAGGTTTGTATTTTCCTAGAACTTGAACTAAATTTCAGTTCATAAAATTTATA 
               
               
                   
                   
                 AAATACTTAGTTGTTGTAAAATATTTTTGGAATGTTCACATAGGTGACACACAAATGTC 
               
               
                   
                   
                 CCATTTTCATTCTTTCTATAGTAAATATGTTCTGATATGTGAAGGTTTAGCAGATGCAT 
               
               
                   
                   
                 CAGCATTTAATCCTAGAGGATCTGGCATAATCTTTTCCCCCAAGAATAGAAATTTTTT 
               
               
                   
                   
                 CTGCTTATGAAAGTAGTACATGTTTCTTTAAAAACAAATCAATATTGACTTCTGCCTGC 
               
               
                   
                   
                 TGTATAGCACTATGCCTCCACCTGGCCATGACCAGGGGCATGTCCTGGTCCACCTA 
               
               
                   
                   
                 CCTGAAAATGTTTGCAACCAGCCTCCTGGCCATGTGCACAGGGGCTGAAGTTGTCC 
               
               
                   
                   
                 CACAGGTATTACGGGCCAACCTGACAATACATGAAGTTCCACCAAAGTCTGAGAACT 
               
               
                   
                   
                 CAGAACTGAGCTTTGGGGACTGAAAGACAGCACAAACCTCAAATTTCTCAGCACTGG 
               
               
                   
                   
                 AAACCTCAAAATATAACTGAATTCCATAAATAAGATTTTAAGTCTTAAATATGTATTTTT 
               
               
                   
                   
                 AAATGTATTAAAAGTCAAGCTGCTTGTATTTAAGCACCTAATACAATGCTTAGGTTGT 
               
               
                   
                   
                 AAAAGGAGATGCTCAATAGGTACTAACTGATATATTGAGATTTAATTATGGTTTGACC 
               
               
                   
                   
                 AATATTTATTGGAAACCGCCAAAGCTTAAATCATCAGCTTCTTGAATGTGATTTGAAA 
               
               
                   
                   
                 GGTAATTTAGTATTGAATAGCATGTGAGCTAGAGTATTTCATTCTTTCTGGTTTATTTC 
               
               
                   
                   
                 TTCAAATAGACTTTGAATATAATGGTGAATGGGTATTATAAATTAACTAATAAAAATGA 
               
               
                   
                   
                 CATTGAAAATGAAAAAATATATATATTAAAGTGTAGAAAGTGACCAGGCGTGGTGGCT 
               
               
                   
                   
                 CACACCTGTAATCCAAGCACCTTGGGAGGCTGAGGCAGGAGGATCTCTTGATCCCA 
               
               
                   
                   
                 GGAGTTCAAGACCAGCCTGGGCAACATAGCGAGACTTCGTCTCTAAAAAAAAAAAAG 
               
               
                   
                   
                 AGAGAGAAAAAAATTTTTTTTATTTAAAAAAAGTGTAGAAAGTGTCAAGACCCCACTT 
               
               
                   
                   
                 CTTACCATTATTTGGTATATTTCTCTATACCCACCCACCCTTCCTCCTTACTCCCTCCC 
               
               
                   
                   
                 TCCCTTCCCAATCTTTTTATCTTTTTGTATTCTGATTTTTTGTTTGTATATTTTGCTTTAA 
               
               
                   
                   
                 TTTAATGTATCCTTTAAAAATTTCCCATACATTTTATATGTATATATAAAAACGCATGCT 
               
               
                   
                   
                 GCCAAAGATAATTTATAAGAAAGACCATTGAATTTTTTTAAAAGTGATATATATTCATT 
               
               
                   
                   
                 GAAAAAAATTTAGAATATATAGCAAAGCAATAAAGAACTAAATAAAATTGCTGTAACTC 
               
               
                   
                   
                 CTCTTTCAAAGATAAGTGCTTTTATGATTTTGTTGTATTTTTTTCTGTATATAGGTACAT 
               
               
                   
                   
                 ATATAGTATTTATAAAGCTGTACTCATAGTACATTTTCACATCACAGGTACCATATCAG 
               
               
                   
                   
                 TGTTATTAAATATTTTGTATGCCAGGGGCTAGACATACCAAGACAACCAATATGTGGT 
               
               
                   
                   
                 TCTACTTAAATAATATTAGAGTATCTTTTATGATGACACTTCATGAGTTGACTATAATA 
               
               
                   
                   
                 ATCTTAGACTTCTAAGAGTTTGGGTTTTCAAAAGATCACTTAGCTTTTTTGGGTGATTT 
               
               
                   
                   
                 TTCCCCCTTACTGTGAGATGAGAGAGGCTGTTTGGATTTGGGATTGGGGTAGCGGG 
               
               
                   
                   
                 GACAGCAACTTTTCTTTTCTTTTTCTTTTTTATTTTGAGGTAGGGTATTGCTGTGTCAC 
               
               
                   
                   
                 CCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCCACCTCCCGGGC 
               
               
                   
                   
                 TCAGGTGATCCTCCTGCTTCAGCCTCCCAGTAACTGGGACTACAGGCGCGTGCCAC 
               
               
                   
                   
                 ATGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCT 
               
               
                   
                   
                 GGTCTCTAACTCCTGACCTCAGGTGATACGCCCACCTGGGCCTCCCAAAATACTGG 
               
               
                   
                   
                 GATTACAGGCATGAGCCGCTGCATCAGCCAGCAGTTTTTCTTGTGGTTTTTTTTGTTT 
               
               
                   
                   
                 GTTTTGTTTTGTTTTGTTTTTGAGATAGGGTCTTACTCTGTTGTCCACGCTGGAGTGC 
               
               
                   
                   
                 TGTGGTATGATCGTAGCTCACTGCAGCCTCAAACTCCTGGGCTCAAGTGATTCCTTC 
               
               
                   
                   
                 TGCCTCCGCCTCCCGAGTAGCTGGGACTACAGGTATGCACCACCATACCTGGCAAA 
               
               
                   
                   
                 TTTTTACAAAGTTTTTTGTAGGGACGGGGTCTTGCTACATTCCCCATGTCGGTCTTGA 
               
               
                   
                   
                 ACTCCTGGCCTCAAGCAACTCTCCTGTCTCAGCCTCCCAAAGCACTGGGATTACAAG 
               
               
                   
                   
                 TGTGAGCCACCACACCATGCCAGTTTTTCCTGTTCAGTGTGATATTTTATCTTGTTAG 
               
               
                   
                   
                 ACTACAGTGTGTTAAAACTTGTTTTACTAAATTTTCAAACATACTCAAAAGTGGAGAGA 
               
               
                   
                   
                 ATAGTATAATGAATACCCGTATGTTCATCACCCATGTTTAGAATATTATTAAATATAAA 
               
               
                   
                   
                 GATTTTGCTGCGTTTGTCTTAGCTCTTTAAAATTTTTCTTTTTCTCTTTGTGACCTAAA 
               
               
                   
                   
                 GGAAATTCCATATCTTATCACTTTACTTCTACATTCTTGACTAAGATGACTAAGACATA 
               
               
                   
                   
                 TAGTTACATGGTTTTTTGTTTTGTTTTTGTTTTTTAAAGACGAAATCTCGCTCTTGTCC 
               
               
                   
                   
                 CCCAGGCTGGAGTGCAATGGTGCCATCTCAGCTCAGTGCAACCTCTGCCTTCTGGG 
               
               
                   
                   
                 TACAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCTCCTGCCA 
               
               
                   
                   
                 CCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGCGGGGGGAGGTTTCACCAT 
               
               
                   
                   
                 GTTGACAAGGCTGGTCTGGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTC 
               
               
                   
                   
                 CCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCTGTTTTTTTGTTTGT 
               
               
                   
                   
                 GTGTTTTGTTTTTTTTGAGACAGAGTCTTGCTCTGTTTCCCAGGCTGGAGTGAAGTG 
               
               
                   
                   
                 GTGCCATCTCAGCTCAGAGACAGAGTCTTGCTCTGTTTCCCAGGCTGGAGTGAAGT 
               
               
                   
                   
                 GGTGCCATCTTGGCTCACTGCAACCTTCACCTCCCAGGTTCAAGTGATTCTCCTGCC 
               
               
                   
                   
                 TCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGTCACCACACCCGGCTAATTTTT 
               
               
                   
                   
                 TTGTATTTTTAGTAGAGACGGGATTTCACCGTGTTGCCCAGGCTGGTCTCGAACTCC 
               
               
                   
                   
                 TGAGCTCAGGCAGTCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGTGTG 
               
               
                   
                   
                 AACCAACCCGCCCGGCCTGTTGTTTTCTTACATAATTCATTATCATACCTACAAAGTT 
               
               
                   
                   
                 AACAGTTACTAATATCATCTTACACCTAAATTTCTCTGATAGACTAAGGTTATTTTTTA 
               
               
                   
                   
                 ACATCTTAATCCAATCAAATGTTTGTATCCTGTAATGCTCTCATTGAAACAGCTATATT 
               
               
                   
                   
                 TCTTTTTCAGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTA 
               
               
                   
                   
                 ATCATTATGCTGAGGATTTGGAAAGGGTGTTTATTCCTCATGGACTAATTATGGACAG 
               
               
                   
                   
                 GTAAGTAAGATCTTAAAATGAGGTTTTTTACTTTTTCTTGTGTTAATTTCAAACATCAG 
               
               
                   
                   
                 CAGCTGTTCTGAGTACTTGCTATTTGAACATAAACTAGGCCAACTTATTAAATAACTG 
               
               
                   
                   
                 ATGCTTTCTAAAATCTTCTTTATTAAAAATAAAAGAGGAGGGCCTTACTAATTACTTAG 
               
               
                   
                   
                 TATCAGTTGTGGTATAGTGGGACTCTGTAGGGACCAGAACAAAGTAAACATTGAAGG 
               
               
                   
                   
                 GAGATGGAAGAAGGAACTCTAGCCAGAGTCTTGCATTTCTCAGTCCTAAACAGGGTA 
               
               
                   
                   
                 ATGGACTGGGGCTGAATCACATGAAGGCAAGGTCAGATTTTTATTATTATGCACATCT 
               
               
                   
                   
                 AGCTTGAAAATTTTCTGTTAAGTCAATTACAGTGAAAAACCTTACCTGGTATTGAATG 
               
               
                   
                   
                 CTTGCATTGTATGTCTGGCTATTCTGTGTTTTTATTTTAAAATTATAATATCAAAATATT 
               
               
                   
                   
                 TGTGTTATAAAATATTCTAACTATGGAGGCCATAAACAAGAAGACTAAAGTTCTCTCC 
               
               
                   
                   
                 TTTCAGCCTTCTGTACACATTTCTTCTCAAGCACTGGCCTATGCATGTATACTATATG 
               
               
                   
                   
                 CAAAAGTACATATATACATTTATATTTTAACGTATGAGTATAGTTTTAAATGTTATTGGA 
               
               
                   
                   
                 CACTTTTAATATTAGTGTGTCTAGAGCTATCTAATATATTTTAAAGGTTGCATAGCATT 
               
               
                   
                   
                 CTGTCTTATGGAGATACCATAACTGATTTAACCAGTCCACTATTGATAGACACTATTTT 
               
               
                   
                   
                 GTTCTTACCGACTGTACTAGAAGAAACATTCTTTTACATGTTTGGTACTTGTTCAGCTT 
               
               
                   
                   
                 TATTCAAGTGGAATTTCTGGGTCAAGGGGAAAGAGTTTATTGAATATTTTGGTATTGC 
               
               
                   
                   
                 CAAATTTTCCTCTAAGAAGTTGAATCATTTTATACTCCTGATGTTATATGAGAGTACCT 
               
               
                   
                   
                 TTCTCTTCACAATTTGTCTCTTTTTTTTTTTTTTTTGAGACAAGGTCTCTGTTGCCCAG 
               
               
                   
                   
                 GCTGGGGTGCAGTGCAGCAGAATGATCACAGTTCACTGCAGTCTCAACCTCCTGGG 
               
               
                   
                   
                 TTCAAGCGATCCTTCCACCTCAGCCTCCTGAGTAGCTGGGACTATAGGTGTGCGCC 
               
               
                   
                   
                 ACCACTCCCAGCTAATATTTTTATTTTGTAGAAACAGGGTTCGCCATGTTACCCAGCC 
               
               
                   
                   
                 TCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGGCCCAGTTTCTACAGTCTCTCT 
               
               
                   
                   
                 TAATATTGTATATTATCCAGAAAATTTCATTTAATCAGAACCTGCCAGTCTGATAGGTG 
               
               
                   
                   
                 AAAATGGTATCTTGTTTTTATTTGCATTTAAAAAAAATTATGATAGTGGTATGCTTGGT 
               
               
                   
                   
                 TTTTTTGAAGGTATCAAATTTTTTACCTTATGAAACATGAGGGCAAAGGATGTGATAC 
               
               
                   
                   
                 GTGGAAGATTTAAAAAAAATTTTTAATGCATTTTTTTGAGACAAGGTCTTGCTCTATTG 
               
               
                   
                   
                 TCCAGGCTGGAGTGCAGTGGCACAATCACAGTTCACTCCAGCCTCAACATCCTGCA 
               
               
                   
                   
                 CTAAAGTGATTTTCCCACCTCACCTCTCAAGTAGCTGGGACTACAGGTACATGCTAC 
               
               
                   
                   
                 CATGCCTGGCTAATTTTTTTTTTTTTGCAGGCATGGGGTCTCACTATATTGCCCAGGT 
               
               
                   
                   
                 TGGTGTGGAAGTTTAATGACTAAGAGGTGTTTGTTATAAAGTTTAATGTATGAAACTT 
               
               
                   
                   
                 TCTATTAAATTCCTGATTTTATTTCTGTAGGACTGAACGTCTTGCTCGAGATGTGATG 
               
               
                   
                   
                 AAGGAGATGGGAGGCCATCACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAA 
               
               
                   
                   
                 ATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCC 
               
               
                   
                   
                 ATTCCTATGACTGTAGATTTTATCAGACTGAAGAGCTATTGTGTGAGTATATTTAATAT 
               
               
                   
                   
                 ATGATTCTTTTTAGTGGCAACAGTAGGTTTTCTTATATTTTCTTTGAATCTCTGCAAAC 
               
               
                   
                   
                 CATACTTGCTTTCATTTCACTTGGTTACAGTGAGATTTTTCTAACATATTCACTAGTAC 
               
               
                   
                   
                 TTTACATCAAAGCCAATACTGTTTTTTTAAAACTAGTCACCTTGGAGGATATATACTTA 
               
               
                   
                   
                 TTTTACAGGTGTGTGTGGTTTTTTAAATAAACTCCTTTTAGGAATTGCTGTTGGGACTT 
               
               
                   
                   
                 GGGATACTTTTTTCACTATACATACTGGTGACAGATACCCTCTCTTGAGCTACATCGG 
               
               
                   
                   
                 TTTGTGGGGAGTCAAAAGTCCTTTGGAGCTAGGTTTGACAAATAAGGTGGGTTAACA 
               
               
                   
                   
                 CTTGTTTCCTAGAAAGCACATGGAGAGCTAGAGTATTGGCGAATTGAAGAAATCCCC 
               
               
                   
                   
                 CTTTTTTTTTAACACACTTAAGAAAGGGGACTGCAGGTATACTCAAGAGAGTAAGTCG 
               
               
                   
                   
                 CACCAGAAACCACTTTTGATCCACAGTCTGCCTGTGTCACACAATTGAAATGCATCA 
               
               
                   
                   
                 CAACATTGACACTGTGGATGAAACAAAATCAGTGTGAATTTTAGTAGTGAATTTCATT 
               
               
                   
                   
                 CATAATTTGATCGTGCAAACGTTTGATTTTTATTACTTTAGACTATTGTTTCTGATTTTA 
               
               
                   
                   
                 TGTTGGGTTGGTATTTCCTGTGAGTTACTGTTTTACCTTTAAAATAGGAATTTTTCATA 
               
               
                   
                   
                 CTCTTCAAAGATTAGAACAAATGTCCAGTTTTTGCTGTTTCATGAATGAGTCCTGTCC 
               
               
                   
                   
                 ATCTTTGTAGAAACTCGCCTTATGTTCACATTTTTATTGAGAATAAGACCACTTATCTA 
               
               
                   
                   
                 CATTTAACTATCAACCTCATCCTCTCCATTAATCATCTATTTTAGTGACCCAAGTTTTT 
               
               
                   
                   
                 GACCTTTTCCATGTTTACATCAATCCTGTAGGTGATTGGGCAGCCATTTAAGTATTAT 
               
               
                   
                   
                 TATAGACATTTTCACTATCCCATTAAAACCCTTTATGCCCATACATCATAACACTACTT 
               
               
                   
                   
                 CCTACCCATAAGCTCCTTTTAACTTGTTAAAGTCTTGCTTGAATTAAAGACTTGTTTAC 
               
               
                   
                   
                 GGTATCGATAAGCTTGATATCAAAACGCCAACTTTGACCCGGAACGCGGAAAACACC 
               
               
                   
                   
                 TGAGAAAAACACCTGGGCGAGTCTCCACGTAAACGGTCAAAGTCCCCGCGGCCCTA 
               
               
                   
                   
                 GACAAATATTACGCGCTATGAGTAACACAAAATTATTCAGATTTCACTTCCTCTTATTC 
               
               
                   
                   
                 AGTTTTCCCGCGAAAATGGCCAAATCTTACTCGGTTACGCCCAAATTTACTACAACAT 
               
               
                   
                   
                 CCGCCTAAAACCGCGCGAAAATTGTCACTTCCTGTGTACACCGGCGCACACCAAAAA 
               
               
                   
                   
                 CGTCACTTTTGCCACATCCGTCGCTTACATGTGTTCCGCCACACTTGCAACATCACA 
               
               
                   
                   
                 CTTCCGCCACACTACTACGTCACCCGCCCCGTTCCCACGCCCCGCGCCACGTCACA 
               
               
                   
                   
                 AACTCCACCCCCTCATTATCATATTGGCTTCAATCCAAAATAAGGTATATTATTGATGA 
               
               
                   
                   
                 TGTTT 
               
               
                   
               
               
                 122 
                 HDAdHER2BiTE 
                 AAACATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGGGGGT 
               
               
                   
                   
                 GGAGTTTGTGACGTGGCGCGGGGCGTGGGAACGGGGCGGGTGACGTAGGTTTTAG 
               
               
                   
                   
                 GGCGGAGTAACTTGTATGTGTTGGGAATTGTAGTTTTCTTAAAATGGGAAGTGACGT 
               
               
                   
                   
                 AACGTGGGAAAACGGAAGTGACGATTTGAGGAAGTTGTGGGTTTTTTGGCTTTCGTT 
               
               
                   
                   
                 TCTGGGCGTAGGTTCGCGTGCGGTTTTCTGGGTGTTTTTTGTGGACTTTAACCGTTA 
               
               
                   
                   
                 CGTCATTTTTTAGTCCTATATATACTCGCTCTGCACTTGGCCCTTTTTTACACTGTGAC 
               
               
                   
                   
                 TGATTGAGCTGGTGCCGTGTCGAGTGGTGTTTTTTTAATAGGTTTTCTTTTTTACTGG 
               
               
                   
                   
                 TAGGCGCGCCGTCGACGCGACAACTGTCTTATTACCCTGTTATCCCTACCTTAATTA 
               
               
                   
                   
                 AGCTAGCCGACGCGTTGGCCAGGAGCTCAGATCTCCGGATCCAAGCTTATCGATTT 
               
               
                   
                   
                 CGAACCCAAATGGATCTACCACATTTGTAGAGGTTTTACTTGCTTTAAAAAACCTCCC 
               
               
                   
                   
                 ACACCTCCCCCTGAACCTGAAACATAAAATGAATGCAATTGTTGTTGTTAACTTGTTT 
               
               
                   
                   
                 ATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAG 
               
               
                   
                   
                 CAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTT 
               
               
                   
                   
                 TGTCCAAACTCATCAATGTATCTTATCATGTCGAGCTAGCTAGTCAGGACTTCAGTTC 
               
               
                   
                   
                 CAGCTTTGTGCCGGCTCCGAAGGTCAGCGGGTTGCTAGACCATTGCTGACAGTAAT 
               
               
                   
                   
                 ATGTGGCGGCATCCTCGGCTTCCATAGAGCTGATTGTCAGGCTGTAGCTGGTGCCA 
               
               
                   
                   
                 GATCCAGATCCGCTGAATCTGTAGGGCACGCCGGAGGCCACTTTGCTTGTGTCGTA 
               
               
                   
                   
                 GATCCACCGCTTGGGGCTTGTGCCAGACTTCTGCTGATACCAGTTCATGTAGGACAC 
               
               
                   
                   
                 GCTGCTGCTGGCTCTGCATGTCATGGTCACTTTCTCGCCTGGGGAAGCGCTCATGA 
               
               
                   
                   
                 TGGCGGGGCTTTGTGTCAGCTGAATATCGGAGCCACCACCACCGCTTCCACCACCA 
               
               
                   
                   
                 CCTGAACCGCCTCCGCCACTAGAAACTGTCAGGGTTGTGCCCTGGCCCCAGTAATC 
               
               
                   
                   
                 CAGACAGTAGTGGTCGTCGTAGTACCGGGCACAATAGTACACAGCGCTATCTTCAG 
               
               
                   
                   
                 AGGTCAGGCTGGACAGCTGCATGTAGGCGGTAGAGCTGCTCTTGTCGGTGGTCAGT 
               
               
                   
                   
                 GTGGCCTTGTCCTTGAACTTCTGGTTGTAATTGGTGTAGCCCCGGCTGGGGTTGATG 
               
               
                   
                   
                 TAGCCGATCCATTCCAGTCCTTGGCCAGGCCTCTGCTTGACCCAGTGCATGGTGTA 
               
               
                   
                   
                 CCGGGTGAATGTGTAGCCGCTGGTCTTGCAGGACATCTTCACAGAGGCGCCAGGTC 
               
               
                   
                   
                 TAGCCAGTTCGGCGCCAGACTGTTGCAGCTTGATATCGGATCCACCGCCACCAAGG 
               
               
                   
                   
                 GCTTTGATTTCCAGCTTGGTGCCGCTGCCGAAGGTGAAAGGGGTTCTGAAGTGCTG 
               
               
                   
                   
                 CTGACAAAAGTACACGGCCAGATCCTCGGCCTGCACGCTGCTGATGGTAAAGGTGA 
               
               
                   
                   
                 AGTCAGGGCCAGAGCCAGAGCCGGTGAATCTAGAGGGCACGCCTGTGTATCTGCT 
               
               
                   
                   
                 GCTGGCGCTGTAGATCAGCAGCTTAGGAGACTGGCCAGGCTTCTGCTGATACCAGG 
               
               
                   
                   
                 CCACGGCGTTGTACACGTCCTGGCTGGCTTTACAGGTGATGGACACTCTGTCGCCC 
               
               
                   
                   
                 ACGCTGGTGCTCAGAAACTTGTGGCTCTGGGTCAGCTGAATATCAGATCCTCCGCC 
               
               
                   
                   
                 GCCTGAACCTCCGCCTCCGCTTCCTCCGCCACCAGAAGAGACTGTCACGGTTGTGC 
               
               
                   
                   
                 CCTGGCCCCAATATGGCACGTAGCCGTGGTACACTTCCCATCTGGCACAAAAGTAG 
               
               
                   
                   
                 GTGGCCATGTCCTCGGACTTCAGGTTGTTGATCTGCAGGTAGGCGGTGTTGGCGCT 
               
               
                   
                   
                 GGTTTCCAGGCTGAAGTCGAATCTGCCCTTGAAATCGTCGGCGAAGGTGCTCTCGC 
               
               
                   
                   
                 CGGTGCTGGTATTGATCCAGCCCATCCATTTCAGGCCCTGTCCAGGGGCCTGCTTG 
               
               
                   
                   
                 ACCCAGTTCATGCCGTAGTTGGTGAAGGGGTAGCCGCTGGCCTTGCAGGAGATCTT 
               
               
                   
                   
                 CACTGTCTCGCCAGGTTTCTTCAGCTCGGGGCCAGACTGCTGCAGCTGAACTTCAG 
               
               
                   
                   
                 AATGGGCGCCTGTGGCGGCTCCCACAAGAAACAGGATGCGCCAGATCCAGTCCATG 
               
               
                   
                   
                 GTGGCCCTCCTTCGCCGGTGATCTCAGCTGTAGGAAAGAGAAGAAGGTTAGTAGTC 
               
               
                   
                   
                 GACGTGTCCCTCTCGATGAATCTAAGTATCAATTGTGAGCGCTCACAAGTCAACACT 
               
               
                   
                   
                 CTTTTTGATAAATCTAGTAGATATCACTTACGTAGGCGCCGGTCACAGCTTGGATCTG 
               
               
                   
                   
                 TAACGGCGCAGAACAGAAAACGAAACAAAGACGTAGAGTTGAGCAAGCAGGGTCAG 
               
               
                   
                   
                 GCAAAGCGTGGAGAGCCGGCTGAGTCTAGGTAGGCTCCAAGGGAGCGCCGGACAA 
               
               
                   
                   
                 AGGCCCGGTCTCGACCTGAGCTTTAAACTTACCTAGACGGCGGACGCAGTTCAGGA 
               
               
                   
                   
                 GGCACCACAGGCGGGAGGCGGCAGAACGCGACTCAACCGGCGTGGATGGCGGCC 
               
               
                   
                   
                 TCAGGTAGGGCGGCGGGCGCGTGAAGGAGAGATGCGAGCCCCTCGAAGCTTCAGC 
               
               
                   
                   
                 TGTGTTCTGGCGGCAAACCCGTTGCGAAAAAGAACGTTCACGGCGACTACTGCACT 
               
               
                   
                   
                 TATATACGGTTCTCCCCCACCCTCGGGAAAAAGGCGGAGCCAGTACACGACATCAC 
               
               
                   
                   
                 TTTCCCAGTTTACCCCGCGCCACCTTCTCTAGGCACCGGTTCAATTGCCGACCCCTC 
               
               
                   
                   
                 CCCCCAACTTCTCGGGGACTGTGGGCGATGTGCGCTCTGCCCACTGACGGGCACC 
               
               
                   
                   
                 GGAGCGATCGCAGATCCTTCGATAGAGAAATGTTCTGGCACCTGCACTTGCACTGG 
               
               
                   
                   
                 GGACAGCCTATTTTGCTAGTTTGTTTTGTTTCGTTTTGTTTTGATGGAGAGCGTATGT 
               
               
                   
                   
                 TAGTTACGATTCACACAAAAAACCAACACACAGATGTAATGAAAATAAAGATATTTTAT 
               
               
                   
                   
                 TGCGGCCGCTCGAGTCTAGAGGTATACATGCCATGGTCCGCGGTATTACCCTGTTAT 
               
               
                   
                   
                 CCCTAAGACAACTGTCCTGCATGCGACGTCGGCGCGCCATCGAATTCCTGCAGCCC 
               
               
                   
                   
                 GGGGGATCCCTTTGTTGATTTTTTCCACATAGATTATTTTTGACTGTTTTGGCACTTTA 
               
               
                   
                   
                 TATAAATGGAATCATATAGTAAATATATACATGTATATATGTATATATACACTATATATG 
               
               
                   
                   
                 TATATATATAGTGTATATATATACATGTATATATGTATATTTACATATATACTGTATATA 
               
               
                   
                   
                 TGTATATTTACATATATACTGTATATATGTATATATACACGTATATACTGTATATATACA 
               
               
                   
                   
                 GTATATACTGTATATATATACTGTATATATGTGTATATATATATACAGTATATATACAGT 
               
               
                   
                   
                 ATACATATATATACATGTATATATACACAGTATATATACATGTATATATACACAGTATAT 
               
               
                   
                   
                 ATACATGTATATATACACAGTATATATACATGTATATATACACAGTATATATACACTGT 
               
               
                   
                   
                 ATATATGTATATATATACTGTGTATATATATACAGTATATATACAGTATATATATACATG 
               
               
                   
                   
                 TATATGTATATATATACTGTATATATGTGTATATATACGTATATATACTGTATATATATA 
               
               
                   
                   
                 TAGACACTTTTGTGTCTGGCTTCTTGCTCTCATCATAAAGCACTTGAAATCCATCCAT 
               
               
                   
                   
                 GTTGTAGCTGGTATCAGTAGCTAGTTTCTTTTCATTGCTGAGAAGTATCACTTTTTATT 
               
               
                   
                   
                 GATGAGTAGTTTTACATTGTATGAACATGCCCGAGTTTGTTTATGCATTCTACTAATA 
               
               
                   
                   
                 GACACCTGGGCTGTTTGCAGTTTTTGGCTATTACAAAGAAAATTTCTATATTTTTTTCC 
               
               
                   
                   
                 AACTTTTATTTTAGGTTCAGCGGGTACATGGGCAGGTTTGTTACATCGGTAAATTGCA 
               
               
                   
                   
                 TGTCACTGGGGTTTGGTGTACAGATTATTTCACCACCCAGGTAATAAGCATAGTACC 
               
               
                   
                   
                 TGATAGGCAGGTTTTTGATCCTCACCCTCCTCCCTCAAGTAGGCCCCAGTGTCTATT 
               
               
                   
                   
                 GTTCTATTCCTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTTGCCCAGGCTGGAG 
               
               
                   
                   
                 TGCAGTGGTGCGATCTCGGCTCACTGCAAGGTCCACCTCCAGGGTTCAAGCGATTC 
               
               
                   
                   
                 TACTGCCGCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCACCACCACGCCCGG 
               
               
                   
                   
                 CTAATTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCCAGGATGGTCTCG 
               
               
                   
                   
                 AACTCCTCACCTCAGGTGATCCGCCCGCTTCGGCCTCGCAAAGTACTGGGATTACA 
               
               
                   
                   
                 GGCGTGAGCCACGGTGCCTGGCCTATGGTTCCATTCTTTGTGTACACGTGTACTCA 
               
               
                   
                   
                 GTGTTTAGCTTCCACTTGTAAGTGAAAACATGCAGTATTTGGTTTTCTGAAATTCTTGT 
               
               
                   
                   
                 CTTCATCTTTTTGTAGACAATCCACTACTTTTATTTTTAAATATTAGGAACAATAGCCT 
               
               
                   
                   
                 CTGTGTGTCCTGAATTGCAATGTTTTTTCTCTGATTTTGCTGCTCATCTTGTAACCTGT 
               
               
                   
                   
                 ATGGTGTTTTTCTGTGTGCAAGCTTTTTACTTTACGTGGGCAATTTTATCATTCTTTTC 
               
               
                   
                   
                 TTTTATGGTTTCTGGGTTTCATGTCATGATTGGAGAAGCTTGATCTACCCTGATACTA 
               
               
                   
                   
                 TAAAAATATCCACCTTGGCTTTTTTTTTTTTTTTTAGATGGATTTTCACTCTTGTTGCCC 
               
               
                   
                   
                 AGGCTGGAGTGCAATGGCGTGATCTCGGCTCACCACAACCTCTGCCTCCCAGGTTC 
               
               
                   
                   
                 AAGTGATTCTCCTGCCTCGGCCTCCTGAGTAGCTGGGATTACAGGCATGCGCCACC 
               
               
                   
                   
                 ACGCTCAGCTAATTTTGTATTTTTAGTAGAGACAGGATTTCACCATGTTGGTCAGGCT 
               
               
                   
                   
                 GGTCTTGAACTCCCCACCTCAGGTGATCTGTCTGCCTCGGCCTCCCAAAGTGCTGG 
               
               
                   
                   
                 GATTACAGGCGTGACCCACCACACCTGGCCCACGTTGTTTTCTGATAGTGTTTTCAC 
               
               
                   
                   
                 GTGTTATTTTTTCTGTCTTACTCTTTGAATCATCTAAATGTATCTTAATGTCAGGAGTG 
               
               
                   
                   
                 AGGTAGAGGACCCAGTTGTTTGGTTTAAATGACTAGCCAGTTTTCCCAACACCAGGT 
               
               
                   
                   
                 GTTGAACATCCCTCACTGATGTGAGATGCTGCCTTTTTCACAGTCTCAATCCCCATGT 
               
               
                   
                   
                 GCATTTCTATTTATTTTCCTTCCACTTTATTCACATCTTTTTCAGTATCCACAACCATAT 
               
               
                   
                   
                 TGTTTTAAATAGCTTCATGATATGTTTTAATATTTGGTAGAGCTAGAACCCTTTCTTGG 
               
               
                   
                   
                 TTCTTTTTCTTTTCTTCTTCTCCTCCTTTTCCTCCTCCTTCTTTCTCCTCCTCCTTCTTC 
               
               
                   
                   
                 TTTCTTTTTAGAAATTTCCTGGCTATTCTTGTTTTGTAGTCTTCCAGATAAATAATTTTG 
               
               
                   
                   
                 AATCACTTTGTCATGTTCCAGAAAATAATACTGCCAGAATTTTTATTGTGATCACAGAA 
               
               
                   
                   
                 GTTTTACAGATTCATCTGGGGGAAAAAAACCCATCTTCCCAGAATACAGAAAGGGTG 
               
               
                   
                   
                 AGGGAAAGACAAACATCAAGGACAAGTCTCAGGTTCTGGACTTGGAGACCAAGAGG 
               
               
                   
                   
                 ATTTGGGGCATCCGGGAGCAGGGCAGGGAGGTGTGATGGCTGCCTTTCACTGAGTA 
               
               
                   
                   
                 GGAGGATGCCCAGACTTGGGGGAACTATGGAAAGTTTGGTTCAGACTTTCTGAGTT 
               
               
                   
                   
                 GGAGATGTCTATGCGCAGTCCACAGGGCGAAGCCCTGGAGGTAGAGGCCCTCCTTA 
               
               
                   
                   
                 CTGCCTCCCTCATTCAGTCTGAGGTCCATTCTCCACATGGACACTGAAGTGACTCAA 
               
               
                   
                   
                 GGCTTCCCTTGTTGGATCAGGATAGTCTCCAGGGCCCTGGGTGGTCTGGGCCTGCC 
               
               
                   
                   
                 CACCTCCCCATCCCCTCTCCTGCCTGCCCTCCTCTTGCTCACTGGACCCCACCCAC 
               
               
                   
                   
                 CAGCCTCCTTCTATTCCTCCTGACATTTGCACTTGCTGTTCCGTCTCTGCTTGGAACA 
               
               
                   
                   
                 TCCTAGCTCTTTGCATGGCTTGCTCCTTCCCATCTTTTAATCTAAGCTCAAATATCACT 
               
               
                   
                   
                 CCTTCAGATATGCCTTTCCCAAATATCCTAGCTAAAGAGAACTGCTCCCCACTTCCCA 
               
               
                   
                   
                 CAAGCCCTAGCAAACTGGGACTCTCCTTCTTGCTTTCTTTCTCTCTGCCCCTTCTGTG 
               
               
                   
                   
                 TTTTTTCCATAGACCTTAACTTGTTACTGTTTTATTTGTTGATGTGTTTACATCATTTGT 
               
               
                   
                   
                 CCCCCTGTGATGGTTAGTTTTATGTGTCAACTTGGCTAGGCTGTAGGGGCTGTTCGT 
               
               
                   
                   
                 CAATCAAACACTGATCTATGTGTAGCTGTGAAGGGATTTTGTAGCTGTGATTAATAGT 
               
               
                   
                   
                 TGACTTTAAGTAAGGAAGATTATCCTGGAGAATGTGGGGGAAGGGGCAGACCTCAG 
               
               
                   
                   
                 CCAATCAGTTGAAAGGCCTTAAGAACAAAGCTGAGATTTCCCCGAGGAAGAAGAAAT 
               
               
                   
                   
                 TCTGCCTGTGGACTGCAGCATCAGCTCCTGCTTGAGAGGTTCCAGGCTGCCCTTCC 
               
               
                   
                   
                 TGACAGCCTGTCCTATGATTTTGGACTTGCCTTGCCAGGTTTTTCCTCTTTCTTGACC 
               
               
                   
                   
                 CCCCAAAACCATATATATCTCCTGCTGGTTTGTTTCTCTGGTGTAATCCTGAGGGATG 
               
               
                   
                   
                 AACACTCCTCCCTCCCAGTTCACTCTGGGAGAGGTTGGGGATCATGTTTGTCTATTT 
               
               
                   
                   
                 CCCCATGCCTGGCCCATGCGTGTTTATTGAATCACTGAACAACCACGCATTAGGAAG 
               
               
                   
                   
                 CCAGTCATATGTGCTTCTTCAGAACCTCATGTCCATTGCCAGATCTCCCTGGCTTTTG 
               
               
                   
                   
                 TGGCTAGAGGACAAGTGAGAGATAGTAGCTTACCCACAGACCTTGGCCCTGAGGCC 
               
               
                   
                   
                 CCCAGGGGCCTGAGCCTGCTGTAAGGGAGGAGGGAGCCCCTGAGGTCTCACACAC 
               
               
                   
                   
                 CTCCCTGGGGATCTGGCATTTTCCCCTGGGGCTGGCCTCAGAGCTGGGCGGGGGC 
               
               
                   
                   
                 AGATTATGGAGTGGGTTGTAGAGGGAGCACCTCCCCACTAGCAATCATGGTTTTTTC 
               
               
                   
                   
                 TGCGCCTCTCATAGGGAGGCCTACAGGCCTCCACCTTCAGCTCTTCAGGAGCCACA 
               
               
                   
                   
                 GGCAGCTGAGTGACTTCTGCATCACAGTCTTCTCAGAGACAAACTTGCAGTAAGAAA 
               
               
                   
                   
                 GAGGGGCCCGTGAGGGACCCCAGAGAAGGCTGTTGTCAAAGCAGGATGAGAGTGA 
               
               
                   
                   
                 ACTCTTCCATGGGGGACACCCAGCGTCTCCAAGCTCTTTTATGCTGTCTTCAAGGGG 
               
               
                   
                   
                 TCTAGAGAGCTTCAGCCCAACATGAGACCCAGTCCAGCAGCATTTCCCTGCGAAGT 
               
               
                   
                   
                 GAAAGTTAGGACCCTGACTAGATACACCACGCTGACCTCAGCCAGAATATCAAGATG 
               
               
                   
                   
                 CTGAGGCGCTGAGATGCTGGGATGCTAAGGTGCTAAGGTGCTGGGGTGCTGGGGT 
               
               
                   
                   
                 GCTAGGATGCTGAGGTTTTGTGATACTGGGTCGCTGAGATGCTGGGATACTGGGGT 
               
               
                   
                   
                 GCTGAAGTGCTGGGGTACTGGGGTGTTGCCATGCTGAAATGCTGGGGTGTTGGGAT 
               
               
                   
                   
                 GCTGAGGTGCTGGGTTGCTGGGATGCTGGGATAGTCCTTGGATGCTGCGGTGCTGA 
               
               
                   
                   
                 GATGCTGGTCTGCTGGTCTGCTGGGGTGTTGGGATGCTGGGATTTTGGGATGCTGG 
               
               
                   
                   
                 AGTGCTGCAGTGCTGCAGTGCTGAGATGCTGGAGTGCTGGGGTGCTGGAATACTGT 
               
               
                   
                   
                 AGTACTGGTGTGCTGGAGCATTGAGATGCTAGGGCACTGGGATGCTAAGGTGCTGA 
               
               
                   
                   
                 GATGCTGCAGTGCTGGGGTGTTGGGATGCCGAGGTGTTGGGATGCTTAAGTGCTGG 
               
               
                   
                   
                 GGTGTTGGGATGCTGGGGTGCTGGAACACTATGGTGCTGGGGTGCTGGAGTGTTG 
               
               
                   
                   
                 AGATACTGTAGTGGTGGGATGCTTAAGTGCTGGGGTGCTGGGTGTTGGGATGCCTA 
               
               
                   
                   
                 GGTGCTGGGGTGCCGAGATGCTGGAGTACTAGTGTGCTGGGATGCTGAAGTGCTG 
               
               
                   
                   
                 GGGTCCTGAGATGCTGCAGTGCTAGGGTGCTGAGATTCTGGGCTGCTGGAGTGTTG 
               
               
                   
                   
                 GGGTGCTGGGATGCTGGAGTGCTGAGATGCTTGGACAATGGGGTGCTGGAATACTA 
               
               
                   
                   
                 TGGTGCTGGGGTGCTGGGGTATTGAGATGCTAGGGTACTGGGATGCTGAAGTGCTG 
               
               
                   
                   
                 AGATCCTGGAGTGCTGGGCTGCTGGGCCACAGGCTCTTGAATCCATTCGTCTGCCC 
               
               
                   
                   
                 AGGGGAAGAAACCAGAAGATAAAGAGCTAATGAAGGAGCTTTGGTTGAGAGGGAGG 
               
               
                   
                   
                 AAGTAATGGAAGGAGCAACATCTTGTGGAGGAGCAGGAGAGAATGGACCTCAGGTT 
               
               
                   
                   
                 GGGAGAGAGGGCCAGGCTACAGGCCAGAGAGGCAGAAGGATTCCAGCAGAGTGTG 
               
               
                   
                   
                 GGCTCCAGGAGCCAAGGGGAAACAGGTTTCTGGGAGGAGAGAGTCCAGTACTGCT 
               
               
                   
                   
                 GAAGTGGCAAGTCCGCTGAGGACCAGGAAGCTTCATTTGGCTTTATGACCAGGAGG 
               
               
                   
                   
                 AATTTGGAACTGTGACTAGAGTACTTAGGGGGAAGGAGGCAAGACTGGAGCCAGAT 
               
               
                   
                   
                 TGCTCTGGGTTGAGGGGTGAGTGGGAGGTGAAGCAGGGCACTGTCACTCCTTTGAA 
               
               
                   
                   
                 GGGTGGCAGAGAGCTGGAATTGGTGCTGGATGGGCTGTGGGGTGACAGGGTCATG 
               
               
                   
                   
                 TGGAAAGCCCCTGGGGGGCACCTGGAAAAGGAGAAGCTGACAGTACAGTGAGAGG 
               
               
                   
                   
                 ACAGCTAAGGGAAAGCGGAATGGCAGAACACGCACTGCCAGGAGGAATGAGGATA 
               
               
                   
                   
                 GGGTCAGGAGTGCCAGGGGCAGTGAGGCCAGCCTGGGGTCAGGTGGCAGGACGT 
               
               
                   
                   
                 GTCCAGGAAGCTGGTCTGCACTGCAGCCCACACTGGCTCAGCCTTGAGGTTCCCTG 
               
               
                   
                   
                 TGTGGTTGGGGTAGGAAGTTGAACCCTCTGGGAATGGAAGATGGAACCAGCTCTGC 
               
               
                   
                   
                 GAGCCAAGCTCAGCTTTTATCTATGGGTCTCTGAGGGCTGGCAGAGCTGAGTGGGG 
               
               
                   
                   
                 ACAACTGTGATCCGTGAGGCTCTCAGGTTGAGGTGGCCCCTCCGGGAGGGCTTCAT 
               
               
                   
                   
                 TTTCCCAGCGGGTAGGTTCTAAGCAGCAGTGGCTGGGCAGGTGGGTCCAACACAGA 
               
               
                   
                   
                 GCCAGAGAAGGGTGAATGGGCCTCCTGGCACCCCACCCCTGCTGCCCCTGAGCTC 
               
               
                   
                   
                 AGTGATGGAGGGGGACAGCACAGCTGAGCCCAAGTGCTTTGGTGTGGCCCTGAGG 
               
               
                   
                   
                 GAAAGCTGCAGCCTGCCTGGGGCCTGGCATGGATGGGACACTTGAGGCAGAGGGA 
               
               
                   
                   
                 CAATAGTGGGCGCTGCAGTGAGGCTGGCTCTTGGAGAGGTTTCCTGAGGAGTGCTG 
               
               
                   
                   
                 CCTGAGACGGGCAGGGAGAACAGAGACAAAGTTGGTGACAGGGAATGAAAGCTGA 
               
               
                   
                   
                 CTGAAGGACTTTACCCAGACCTATGAGGATATCTCTCTCAGCAGGAAGCAGGAGGG 
               
               
                   
                   
                 GACTGTGTGAGGACTGGCCAAGAGCTGGAGTGTTGGGAAAATGACTCTTTCTCCGA 
               
               
                   
                   
                 CCCCTCTGTCCTAGCTCTGGCCCCTGGACTGCGGAGGTCTGCTTCCACCCCCATTG 
               
               
                   
                   
                 GTCGATCGTTGTCCCTTGTCACAGCCATTGAGAATTTTGGCAGGGAGCATGTTCTTA 
               
               
                   
                   
                 GAGCATTTTTAGGCTCTGCGGGACATAACAGCTCTGCCTCAGAGCACATGCCTTTCT 
               
               
                   
                   
                 CAGCTCCTGAAAGCCACTGATCAAATTGGAACATTTTGTACCTTAGGGATGAGGATA 
               
               
                   
                   
                 TCAACTCTCCCAGCCACTTAGAGGGATAAATGTGATGATGCATTCAATTGTGACTACA 
               
               
                   
                   
                 TCTGATCCCAACTGTTGCTTCAGCTGCTCTCCTATAGCACATGGCGGGAGGCGTGC 
               
               
                   
                   
                 ATCCCAGTAGCTACCTCCCCACTTTTGGGGAGATGTGGTTCCATCCATGAAACCTGG 
               
               
                   
                   
                 GTACCCGCCTACCAGGTCCTGGCCTATCAGGTGGCAGGGTCTGGTCAAAGAAGGG 
               
               
                   
                   
                 CATGTGTGGTCTTCAGCAAGGGAGACAGGACGGTGGTGCAGAGCGTCTAGACCCTC 
               
               
                   
                   
                 AGGGCAAGTCTCCCCCACACCTGCTCCCGGGGCAGTTGTCTTTGTGACCTCCCATC 
               
               
                   
                   
                 CCCCTCTGTTTCATCCTCTATAAAATGAGGGGCTGAGCCCCAAAATAACAGGCTTCT 
               
               
                   
                   
                 TTGCCATGATGCAAAACTGCTGAATCTTTCTTTCTGACACACAAGGCATCGAGCAGC 
               
               
                   
                   
                 CTCTGAAAGAACCAAAGCCACTAGCAGGCTTCCTGACTTGGGTTTGTAGGTACTGAA 
               
               
                   
                   
                 TACTCCCTTGAAAAATAAAAACATAGAGGCACTTTTCTCCTGGCTGTTTATTACAGAA 
               
               
                   
                   
                 CGAAGAAAAAACACACTGGCTTGAAACAGACGCCAGATTTCAAATGTAGAGGTGAAA 
               
               
                   
                   
                 TACGAGGTGGCAATTAAAATGTGATTACAGAAAGTCTGGACACTGAGAAAAGTTTAC 
               
               
                   
                   
                 AGGACAGTGGGTGTGGGTTTTCTATAACAGACACTTAAATATACATGACGATAATTGC 
               
               
                   
                   
                 AGATAGAAACCATCAAAGACAAACCCCAAATCAACTAATAATGTTTACAGATGTTCCC 
               
               
                   
                   
                 CCCCAAACCACAGAGCCTTACATCAAAACAAATACTGAAAGGCTTTAAACCAGGAAC 
               
               
                   
                   
                 AGCTCGCCTTAACCCCACGAGGGTGCACACAAGCTGGGCTTTTTCTCTCGGTCTGA 
               
               
                   
                   
                 ATGGTAAAGGGAGGAGGATACTCTAGCTCCTCCAGGTGGATTGCTGAGACAGGGCT 
               
               
                   
                   
                 CGGCTCACACACTGTCTCTGCGCCTCTCCCAAATCTGGAGAACTCTCCCAGCCTCCT 
               
               
                   
                   
                 GGTAAAGTGTCTCTGTGGGGCACTTAACGATAAAACAGCTTCTGCTGTAAAGCTCAT 
               
               
                   
                   
                 TAGGAAAGAGCTAGCGGAGACTGAAAGGTTCGCAAAAGAGATTAAGAATCACACAA 
               
               
                   
                   
                 GGCAATAGGATTTTTAGTGAACATAGAAATAAATGGCCAAGTGGTTTTCTATTTGGCA 
               
               
                   
                   
                 TTTGTCAACTTGCACAACAACTCTTGGTCATATCCACATTGCTCATTGCATTAAAACC 
               
               
                   
                   
                 ATAAGCGACTCAGCCACCTAGCTTAACAAGGTATCACTGGAGCAAACAACACGGTCT 
               
               
                   
                   
                 GCATATTTGTAACATTGTATAATAAACACAAAACAATGCATAGTAAACACAACTCTACT 
               
               
                   
                   
                 GAAACAAAAGCCGTCGCTTTATTTACAAAGTCACAAAATGAAGTATAAATACTTCTGT 
               
               
                   
                   
                 CATTAATGTTTAGGAAAACCATTTACAAAATTTTCAAATATGTACACGTAGCTTGAAAA 
               
               
                   
                   
                 ATCACCAGCTTTCCATTTTGTCACAGGTAGAGAGAGGGATAAGCATGGGCTGACAAC 
               
               
                   
                   
                 ACCACTCAAATTGTAACGGGAGACAACTGCGGGTATGGATCGACACCACTTCCTAGA 
               
               
                   
                   
                 GTGATGTCACCATGGGGGTTTCTATGGGCATCCTGCTCAGATTTAAAGTGCCCCAGC 
               
               
                   
                   
                 ATCCTGGGTGACTTGCCCAGAATTCTGGGCTGTGGCATTTTGAGCAGCAGCATGCT 
               
               
                   
                   
                 GTTCCAAAATGTCGTCGATCAGCCTCAAGTTGCACACCCAGTCTTCATCTGGGCTCA 
               
               
                   
                   
                 CACAGGAGCCTTTCAAGAGAGCTTCAATGAAATCTACCTCATTGCAGTCAGGTGACG 
               
               
                   
                   
                 AAATCAGATCATTTAGTGGGGGTTGGGGCTGGCGCAAAAAGTCGGCAGGTGGCAGC 
               
               
                   
                   
                 TCAGGGGGAATATCCGTTCTGTCGAACGGACCTGGGAACTGGCTGGCAGCAACGG 
               
               
                   
                   
                 CAGAAGCAGCAGCAGCGGTGGCAGCAGCAGCCACATAGCTTGGTGGCTCGATGCC 
               
               
                   
                   
                 CTGTATGGGGCTCAGGGGACTAAAGCTGGCCATACCCTGCTGGAGGAACTTGGTGG 
               
               
                   
                   
                 TGTTTGCTACAGGCACCGGGCCCTGTACCGGGCTCTGCCTGAGGCTCTGGCTGCCC 
               
               
                   
                   
                 AGCAGGCTGAAGCTGGGGTTGTTGGCCAGGGGCACTTGTGTTCCCATCGCAGCGG 
               
               
                   
                   
                 GCACTTGTGCCTCCCAATCAGATGGCCTCTGAAGGCAGGCCTGGCCAGAAGGTGAG 
               
               
                   
                   
                 TGCTGCTGAACGCTATTATCCACTTGGCTGAGGGGTGTTTTCCCCGAAACTGCTGTG 
               
               
                   
                   
                 GTCACAGCTGCTGCCGCTGTGACCCATGCAGCATTGTTGAACGCAGTGGGCATTCT 
               
               
                   
                   
                 TGGCACACTAGGCCGTCTGAGCTGGTGGGGACTCAAGGACTGGGTGCCCAGGGAG 
               
               
                   
                   
                 CTGGGACAGAACCCAGGCAGGGGCACTTCTGGTGGGGTGGCCTTGGGGCTCTGCA 
               
               
                   
                   
                 TATGCTGGCAGACAGAGTCAAGTCTGCCCAGGGGAGTCTGGCCTGAGTGTGAGAG 
               
               
                   
                   
                 GATGGGACACTGGGGGCTGGAGGTGAAAATTCCTTGCCGCTTCCCCAGAGTTGGTG 
               
               
                   
                   
                 AGATCACTCCCATGCCCTCGCAGCTCTGGTGCCTGGTGAGTGGGATCATTCCTGGA 
               
               
                   
                   
                 CTCAGATTGTTCTGAAGAAGCCCAGTTCTGGGTGGCATCAAGTGCTTGCTAGATGGG 
               
               
                   
                   
                 GGGCTTGCCTTGATCCGGCTACACTTGGAGGTGACTTGTTCTTGGACGGCTACATAC 
               
               
                   
                   
                 AGAAAGAGAGAAGTGGGGATGAGTTCCAAAGGCATCCTCGACTTCGGCTGTGGCCA 
               
               
                   
                   
                 CCGGAGGGTAGCTCCTGGCCCAACACGGACTTCTCACCTCCCGCCCTTGGCTCTCT 
               
               
                   
                   
                 ACTGAGCTCCCCCCTGCTCCCCAATTCCTCGCCATTCCCCTCATTTCTCTGCCCTCA 
               
               
                   
                   
                 GCCTGGACTGCAGTTCTTCTGGGAAGCTGCCCCAACTCCCTAGGTCTGTGCTCACC 
               
               
                   
                   
                 AAGAGCAGATCACACTGGACTGAAATGCCAGCTGATTTGTCTCTTCAAGAAAATTGG 
               
               
                   
                   
                 AAGCTCCTGGAGGTCAGGGTCCATGTCTGCTTTTACACTCAGTGCTCTGTATGCAGG 
               
               
                   
                   
                 CCTGGCACTGCCCACCCTTTGACAGGTGGTGCATATTTTGTAGAAGGAAGGAAGGG 
               
               
                   
                   
                 GCCAGGTGGGGTGGGCTGGGCTGGTGGCGGGAGCTAGCTCAGCCTCTTAGATTCT 
               
               
                   
                   
                 CTACCCGATGGATGTGACCTGGGACAGCAAGTGAGTGTGGTGAGTGAGTGCAGACG 
               
               
                   
                   
                 GTGCTTTGTTCCCCTCTTGTCTCATAGCCTAGATGGCCTCTGAGCCCAGATCTGGGG 
               
               
                   
                   
                 CTCAGACAACATTTGTTCAACTGAACGGTAATGGGTTTCCTTTCTGAAGGCTGAAATC 
               
               
                   
                   
                 TGGGAGCTGACATTCTGGACTCCCTGAGTTCTGAAGAGCCTGGGGATGGAGAGACA 
               
               
                   
                   
                 CGGAGCAGAAGATGGAAGGTAGAGTCCCAGGTGCCTAAGATGGGGAATACATCTCC 
               
               
                   
                   
                 CCTCATTGTCATGAGAGTCCACTCTAGCTGATATCTACTGTGGCCAATATCTACCGG 
               
               
                   
                   
                 TACTTTTTTGGGGTGGACACTGAGTCATGCAGCAGTCTTATGGTTTACCCAAGGTCA 
               
               
                   
                   
                 GGTAGGGGAGACAGTGCAGTCAGAGCACAAGCCCAGTGTGTCTGACCCACCCAAG 
               
               
                   
                   
                 AATCCATGCTCGTATCTACAAAAATGATTTTTTCTCTTGTAATGGTGCCTAGGTTCTTT 
               
               
                   
                   
                 TATTATCATGGCATGTGTATGTTTTTCAACTAGGTTACAATCTGGCCTTATAAGGTTAA 
               
               
                   
                   
                 CCTCCTGGAGGCCACCAGCCTTCCTGAAACTTGTCTGTGCTGTCCCTGCAACTGGA 
               
               
                   
                   
                 GTGTGCCTGATGTGGCACTCCAGCCTGGACAAGTGGGACACAGACTCCGCTGTTAT 
               
               
                   
                   
                 CAGGCCCAAAGATGTCTTCCATAAGACCAGAAGAGCAATGGTGTAGAGGTGTCATG 
               
               
                   
                   
                 GGCTACAATAAAGATGCTGACCTCCTGTCTGAGGGCAAGCAGCCTCTTCTGGCCCT 
               
               
                   
                   
                 CAGACAAATGCTGAGTGTTCCCAAGACTACCCTCGGCCTGGTCCAATCTCATCCCAC 
               
               
                   
                   
                 TGGTGCGTAAGGGTTGCTGAACTCATGACTTCTTGGCTAGCCTGCAACCTCCACGG 
               
               
                   
                   
                 AGTGGGAACTACATCAGGCATTTTGCTAACTGCTGTATCCTAGGCCAATAAATGTTG 
               
               
                   
                   
                 ATCACATTTATAGCTGCCATGGTAGGGTGGGGACCCCTGCTATCTATCTGTGGAGGC 
               
               
                   
                   
                 TCTGGGAGCCCCTGACACAAACTTTCTGAAGCAGAGCCTCCCCAACCCCTTTTCCAT 
               
               
                   
                   
                 TCCCTATACCTGACAGATGGCCCAGGAACCCATTAGAAATGGAAGGTCACTGCAGC 
               
               
                   
                   
                 AGTATGTGAATGTGCGTGTGGGAGAAGGGCAGGATCAGAGCCCTGGGGGTGTGGC 
               
               
                   
                   
                 AGCCCCCAAGTGATTCTAATCCAGATCCTAGGGTTGTTTCCCTGTCCCATTGAAATA 
               
               
                   
                   
                 GCTGCTTTAAGGGGCCTGACTCAGGGAAATCAGTCTCTTGAATTAAGTGGTGATTTT 
               
               
                   
                   
                 GGAGTCATTTAGACCAGGCCTTCAATTGGGATCCACTAGTTCTAGAGCGGCCGGGC 
               
               
                   
                   
                 CCAGGGAACCCCGCAGGCGGGGGCGGCCAGTTTCCCGGGTTCGGCTTTACGTCAC 
               
               
                   
                   
                 GCGAGGGCGGCAGGGAGGACGGAATGGCGGGGTTTGGGGTGGGTCCCTCCTCGG 
               
               
                   
                   
                 GGGAGCCCTGGGAAAAGAGGACTGCGTGTGGGAAGAGAAGGTGGAAATGGCGTTT 
               
               
                   
                   
                 TGGTTGACATGTGCCGCCTGCGAGCGTGCTGCGGGGAGGGGCCGAGGGCAGATTC 
               
               
                   
                   
                 GGGAATGATGGCGCGGGGTGGGGGCGTGGGGGCTTTCTCGGGAGAGGCCCTTCC 
               
               
                   
                   
                 CTGGAAGTTTGGGGTGCGATGGTGAGGTTCTCGGGGCACCTCTGGAGGGGCCTCG 
               
               
                   
                   
                 GCACGGAAAGCGACCACCTGGGAGGGCGTGTGGGGACCAGGTTTTGCCTTTAGTTT 
               
               
                   
                   
                 TGCACACACTGTAGTTCATCTTTATGGAGATGCTCATGGCCTCATTGAAGCCCCACT 
               
               
                   
                   
                 ACAGCTCTGGTAGCGGTAACCATGCGTATTTGACACACGAAGGAACTAGGGAAAAG 
               
               
                   
                   
                 GCATTAGGTCATTTCAAGCCGAAATTCACATGTGCTAGAATCCAGATTCCATGCTGA 
               
               
                   
                   
                 CCGATGCCCCAGGATATAGAAAATGAGAATCTGGTCCTTACCTTCAAGAACATTCTTA 
               
               
                   
                   
                 ACCGTAATCAGCCTCTGGTATCTTAGCTCCACCCTCACTGGTTTTTTCTTGTTTGTTG 
               
               
                   
                   
                 AACCGGCCAAGCTGCTGGCCTCCCTCCTCAACCGTTCTGATCATGCTTGCTAAAATA 
               
               
                   
                   
                 GTCAAAACCCCGGCCAGTTAAATATGCTTTAGCCTGCTTTATTATGATTATTTTTGTTG 
               
               
                   
                   
                 TTTTGGCAATGACCTGGTTACCTGTTGTTTCTCCCACTAAAACTTTTTAAGGGCAGGA 
               
               
                   
                   
                 ATCACCGCCGTAACTCTAGCACTTAGCACAGTACTTGGCTTGTAAGAGGTCCTCGAT 
               
               
                   
                   
                 GATGGTTTGTTGAATGAATACATTAAATAATTAACCACTTGAACCCTAAGAAAGAAGC 
               
               
                   
                   
                 GATTCTATTTCATATTAGGCATTGTAATGACTTAAGGTAAAGAGCAGTGCTATTAACG 
               
               
                   
                   
                 GAGTCTAACTGGGAATCCAGCTTGTTTGGGCTATTTACTAGTTGTGTGGCTGTGGGC 
               
               
                   
                   
                 AACTTACTTCACCTCTCTGGGCTTAAGTCATTTTATGTATATCTGAGGTGCTGGCTAC 
               
               
                   
                   
                 CTCTTGGAGTTATTGAGAGGATTATAAGACAGTCTATGTGAATCAGCAACCCTTGCAT 
               
               
                   
                   
                 GGCCCCTGGCGGGGAACAGTAATAATAGCCATCATCATGTTTACTTACATAGTCCTA 
               
               
                   
                   
                 ATTAGTCTTCAAAACAGCCCTGTAGCAATGGTATGATTATTACCATTTTACAGATGAG 
               
               
                   
                   
                 GAACCTTTGAAGCCTCAGAGAGGCTAACAGACATACCCTAGGTCATACAGTTATTAA 
               
               
                   
                   
                 GAGAAGGAGCTCTGTCTCGAACCTAGCTCTCTCTCTCTCGAGTAATACCAGTTAAAA 
               
               
                   
                   
                 AATAGGCTACAAATAGGTACTCAAAAAAATGGTAGTGGCTGTTGTTTTTATTCAGTTG 
               
               
                   
                   
                 CTGAGGAAAAAATGTTGATTTTTCATCTCTAAACATCAACTTACTTAATTCTGCCAATT 
               
               
                   
                   
                 TCTTTTTTTTGAGACAGGGTCTCACTCTGTCACCTAGGATGGAGTGCAGTGGCACAA 
               
               
                   
                   
                 TCACTGCTCACTGCAGCCTCGACTTCCCGGGCTCGGGTGATTCTCCCCAGGCTCAG 
               
               
                   
                   
                 GGGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGGACTACAGGTGCGCACCACCAT 
               
               
                   
                   
                 CCCTGGCTAATATTTGTACTTTATTTTATTTATTTATTTATTTATTTTTTGAGATGGAGT 
               
               
                   
                   
                 TTCGCTCTTGTTGCCCGGGCTGGAGTACAGTGGCATGATCTCGGCTCAGTGCAACC 
               
               
                   
                   
                 TCTGCCTCCCGGGTTCAAGCGATTCTCCTACCTCATCCCCCTGAGTAGCTGGGATTA 
               
               
                   
                   
                 CAGGCGCCTGCCACCATGCCTGGCTAATTTTTTGTATTTTTAATAGAGACGAGGTTTC 
               
               
                   
                   
                 ACCATGTTGGCCAGGCTACTCTCGAACTCCTGATCTCAGGTGATCCACCCGCCTTG 
               
               
                   
                   
                 GCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCCGGCCTAATATTTG 
               
               
                   
                   
                 TATTTTTTGTAGAGATGGTGTTTTGCCATGTTGTCCAGGCTGGTCTTGAACTCCTGAG 
               
               
                   
                   
                 CTCAAGCGATCTGCCCGCCTCTGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCC 
               
               
                   
                   
                 ACCGTGCCTGGCCTAGGTAGACGCTTTTAGCTTTGGGGTGTGATGCCTGCCCCAGT 
               
               
                   
                   
                 ATATAGTGAATTTAATTATTGCTAGAGCTGGCTGTTTGTTAGTTTTCTTTGAACATAAG 
               
               
                   
                   
                 ATACTCATTGTTTTTAGTTTGCAAATCCCTCTTCCTTTTTAAAAAATTTCTTTCCCTTAA 
               
               
                   
                   
                 ATTGTTTGCATGTTAGCAATAACAAATGCTTAAATGGTGCTATGTGCTAGATACTCTT 
               
               
                   
                   
                 CTAAGCCCTGTTATGTATATTAACTAATTTTTTAAATTACACAAATCAGAGAGGTTAAG 
               
               
                   
                   
                 TAACTTGCCCAAGATTACCCAACAATACTAGGATTTGAACCTAAGTTTGTCTCACCCC 
               
               
                   
                   
                 AGATTCTGCTCTTAATCTCTAAACTTTTAAGTTAGTAGTGACAATAGTAGGTATTTATT 
               
               
                   
                   
                 GAATACTTAACTATGTTTTAGGCGTTGAAGTAAATATTTTGCAGGCATTATCTAATGTA 
               
               
                   
                   
                 AACACCCTAAAGTTACATAACAGGTACCCTTTAGGTAAATAAACACTAGTATGACCTT 
               
               
                   
                   
                 GGAGGCACAGATAGTTGAAGTAACTTGCCCAATATCACTTACATGAAATTGGCCCTC 
               
               
                   
                   
                 AAATGTGTCTGATACAACCCATGCTGCTTGTAACTATCGTTTTAAACTGCCAGGGTAA 
               
               
                   
                   
                 ACTTGGACACACTTGAGCTAAGAAAAAGCTTTTAGATTTTTGCAAATTAATGTGAAAG 
               
               
                   
                   
                 ATATGCTTTATGTGGATATAATATCTTCTAAATTTCGGGGATGGTAGTCCTAGAAATG 
               
               
                   
                   
                 TAATCCTGCCCTAGCCGAGCTTACCCTGCCAATAATTTTTTACAGAATTGGTAAAACG 
               
               
                   
                   
                 GAGCACCTTTTTTTTGTCCTTGGCCACACTGTTATCAACAGGGTGTAGATTGACATCA 
               
               
                   
                   
                 ATCTGTAGGTGTAAACCAGAATTACTCTTTGTGACCACCAGGAAATAGAGCAGTTCA 
               
               
                   
                   
                 GTTCAGGGGTTTCTTTCTGTGAATTTAGCACTGTGACCTGCATACTACAAGTCTACTT 
               
               
                   
                   
                 TGTTTTCTATCCATTGTTTGTATCTGGGTATTGCAAAAGGTAGGAAAAGGACCAACCA 
               
               
                   
                   
                 GATCAGCAGAGAAGAGTTGCCTTGGAGTTTTCTTTTAGTTTTCTGCAGTTCATTAGAT 
               
               
                   
                   
                 AGTAACTAGGCCATGTCATTTTACTCCCTTGTAGTGAAGATATGTTGAAGTTGTACTG 
               
               
                   
                   
                 GTATACTCTTCTACCTTTCTGTAATTTTATATTGTGTAGACTTGATAAAATTTATGTGTC 
               
               
                   
                   
                 AATCACCACCATTAATATCAATATTGAGCCTCAATTCTTATTTTTCTGCCCAGTGGCT 
               
               
                   
                   
                 GCCAAATTACTAACATTTACAATAATTCACTACTACTAAGATAATCTACTAGTTCGATC 
               
               
                   
                   
                 ACATACTTCAAATTGTTATGGAACTACTGTCTTCAGCATTGTGCTTCTGATAACTGATA 
               
               
                   
                   
                 AGTATAATTTTTTTTTTGTCCAGAGTGAACATGTCTATTCTTCCACTGTACACACTAAT 
               
               
                   
                   
                 AAAAGGAAAAATTGTAATATTGGGTAAATTCATGTCCTTACACATGTAGTAGTTATGA 
               
               
                   
                   
                 GCCCATGTCCCTAGAATGAGTAATAATTTATCCCTCCCTTGGTTGAATAGTCAAGAAT 
               
               
                   
                   
                 GCTGATTTTAATTCTTCTAACAGCTTTATCCCTCAGAAGGGAAGGCAAGCAAGTTATA 
               
               
                   
                   
                 TATGTAGTTTATTTGTAAGACTGATATGAAATTGGAAGATGAATCTACTATTAGCTTTA 
               
               
                   
                   
                 ATTATTTTTACATTTAGGAATATTGCATCAGTAACTCATAATTTTGGTTTTCTGTTATCC 
               
               
                   
                   
                 TGAGTTAACACAAATTATCCAAGGAGATGGCGGATCATCTGCTTTGAGGTGTTTTTTT 
               
               
                   
                   
                 TTGAGAATTTTAATGTATCTGAATATAAAAGGTAAAAATATGCCAACTAGCAATTTCTG 
               
               
                   
                   
                 CCCATTCCAGAAGTTTGGAAATATTACTCATTACTAGGAATTAAATAAAATATGGTTTA 
               
               
                   
                   
                 TCTATTGTTATACCTCTTTTAATTCACATAGCTCATTTTTATCTTTTATTTTTGTTTGTTT 
               
               
                   
                   
                 TTTTTGAGATGGAGTCTTGCTCTGTCACCAGGCAGGAGTGCAGTGATGCAAATCTCG 
               
               
                   
                   
                 GCTCACTCTAGCCACCGACTCCCTGGTTCAAGCGATTCTCCTGCCTGAGCCTTCTGA 
               
               
                   
                   
                 GTAGCTGGGATTACAGGCAGGCACCACCACGCCCAGCTAATTTTTGTAGAGACAGG 
               
               
                   
                   
                 ATTTCACCGTGTTGGCCAGGATGGTCTCCATCTCCTGACCTCATGATCTGCCTGCTT 
               
               
                   
                   
                 CGGCCTCCCAAAGTGCTGGGATTACAGGTGGGAGCCACTACGCCTGGCCCACATAG 
               
               
                   
                   
                 CTCATTTTTAGACTCACTTCCATTAAGTCTTGTTTGGACCCACGAACATTGTCTTTTTT 
               
               
                   
                   
                 TTTTTAAGATGGAGTTTCACTTTTGTTGCCCAGACTGTAGTGCAATGGTGCAATCTCA 
               
               
                   
                   
                 GCTCACTGCAATCTCTGCCTCCTGGGTTCTAGCAATTCTCCTGCCTCAGCCTCCCGA 
               
               
                   
                   
                 GTAGCTGGAATTACAGGCGCCCGCCACCACGCCCAGCTAATTTTTGTGTTTTTAGTA 
               
               
                   
                   
                 GAGACGGGGTTTCACCATGTTGGGCAGGCCAGGGGTGATCCGCCCACCTCAGCCT 
               
               
                   
                   
                 CCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCATCTGGCCAACATGTCTTTTTT 
               
               
                   
                   
                 TTTTTTTTCCTTTTTAACCACAAAGAGACTTAAGCAGTCCTTGTCACAGATGATGAATT 
               
               
                   
                   
                 GATGTTGCAAGTATTGTCTTAGCTTGGATTAATTTTCTTGCTTACTGTAATTTTAGATA 
               
               
                   
                   
                 ATATAGCTTTGTAATTAGAGATTTTATGTGTAAACCACAAAAATGTTTACATGAAGGCC 
               
               
                   
                   
                 ATTATTACAGATGTGACGTGCATAATTATTAGTAATTTGTATGTTTACATGGGTCAGTC 
               
               
                   
                   
                 TGGCAAAAAATTATGAAGTTTTAAAAATTAAAAAAAATTATAATGCCAGTTTTACTGGA 
               
               
                   
                   
                 AAGTAAAATTATTTCAGTAATCGATTATAGCAAAAGTATTGATTTTCATTCCAGACAAA 
               
               
                   
                   
                 AGTCAGAATGAAAGGTAATTTCTCAATACTCTTTCAGATTAATAAAAGTACCTGTAGC 
               
               
                   
                   
                 GATTTTTATCATTCACAAGTATATCACAAGTAAGTTAGAATTTGAGAACTGTGTTCTAG 
               
               
                   
                   
                 ATCTCTGAGGAGATGCAGTCAGATTTCTGAACTGTCTCAGCAAATGGTAAGTAACTTA 
               
               
                   
                   
                 GAGCTAGTAATTAATAACCTGTCCTTTGATTTCTGATTCAGCCAAGAATGGCCATATT 
               
               
                   
                   
                 TGGGAAAGGCAGATCTGGAGAGTAACCACGTTTTCATTCATTTACCACTTCTAGGCC 
               
               
                   
                   
                 CCTCCAGAGCTCTCAGATATTTTGGGGTTGAGCCCTTCCCCAAAGCCATACAGGACC 
               
               
                   
                   
                 TTTTTTTTGTGATCTGTTCTAGCCATTTTTATGTTGGGTGCTTGTTATGGACTGAGCAT 
               
               
                   
                   
                 TTATGTCCTCCCACACCCCCCCCATACCTTTTTTGAAGTCCTAACCCCCAGTGTGAT 
               
               
                   
                   
                 GGTATTTGGAGACAGGGCCTTTGGAAGGTAATTACAGTTAGAAGAAGTCGGGAGGG 
               
               
                   
                   
                 TTGGGCCCAGGTCTGATTGGATTAGTGCCCTTATATGAAAAGACACCAGGACGGGC 
               
               
                   
                   
                 GCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCAC 
               
               
                   
                   
                 GAGGTCAGGAGTTTGAGACCAGCCTGGCCAATGTAGTGAAACACCATCTCTACTAAA 
               
               
                   
                   
                 AATACAAAAATTAGCTGGGTGTGGTAGCGGGCTCCTGTCATCCAAGCTACTCGGGA 
               
               
                   
                   
                 GGGTGAGGCATGAGAATCACTTGAACCCGGGAGTTGGAGGTTGCAGTGAGCCCAG 
               
               
                   
                   
                 ATTGTGCCACTGTACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAGAA 
               
               
                   
                   
                 AAAAAAAAAAAAAGAGACACCAGAGAGCTTGTTAGAAGAGGTCATGTGAGCACACAG 
               
               
                   
                   
                 TTAGAAGACCTTCAAGCCAAAGAAGAGGCCTGAGATTGAAACCTACCTTGCAGGTAC 
               
               
                   
                   
                 CTTAATTTTGGACTTCCCAGCCTCCAAAACTGTGAGAAATAAGTTTCTGTTAAGTCAC 
               
               
                   
                   
                 TCAGTCTGTGGTATTTTGTTATGGCAGCCTGAGCAGGTAGTTGTTCTTTCAGAAGGT 
               
               
                   
                   
                 GTTGATAATAACCACATGCAACACCAAGTCACAAATAATAAAACAGATGTAACTTATA 
               
               
                   
                   
                 TTCATACAGAAAGTTGGGCACTGCCATTGCCTTGTTGGTTTACACGGCTGTGCTAGT 
               
               
                   
                   
                 TCAGTAGCAGAAAGGTGCTGGTCTCCTTTACTCAGTTTACAATCTAGGCAGTAGAAT 
               
               
                   
                   
                 GTAATCACTGCTTTAAACTTGATACTGCTTAGGGAGAGAATCATTGGTGCTGGGTAA 
               
               
                   
                   
                 CTTTGGGTTCTAGGTTTACTTTTTGTGTATATATAACTGTTTTTGGTAAATCACAAGTT 
               
               
                   
                   
                 TCTGGGCTTGTCGAATTAGATTTTGTTACAGATTATGAGCTTTATTATGCTATACAGTT 
               
               
                   
                   
                 AGTTGTATGTATATATGCCTTTCCCACTAGATTTTAAGCTTTTTTTTTTTTTTTTTTTTT 
               
               
                   
                   
                 GTGACGGAGTCTTGCTCTTGTCGCCCAGGCTGAAGTGGAGTGCAGTGGCACAATCT 
               
               
                   
                   
                 CGGCTCACTGCAGCCTCCACCTCCTAGGTTCAAGCGATTCTCCTGCCTCGGCCTCC 
               
               
                   
                   
                 CAAGTAACTGGGACTACAGGCACGTGCCACCACACCCGGCTAATTTTTGTATTTTTT 
               
               
                   
                   
                 GTAGAGACAGGGTTTCGCCATGTTGGCTAGGCTGGTCTTGAACTTCTGGCCTCAGG 
               
               
                   
                   
                 TGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTTACAGGCATGAGCCACCAC 
               
               
                   
                   
                 GCCCAGCTATAGCTCTTTAAGGGTTGTAAATTTATAATCATTCTTTTACTCTCCTGCAA 
               
               
                   
                   
                 ATTCTGTTGCACACTGCCTTAATCAAGGTAGATGCTGAATGCATTTTTGTATAATTGA 
               
               
                   
                   
                 ATATGTTGCAATCCCCAACTCTCTCCAACTGTTCCTGTCAAAGCAGCCACTGGATTGT 
               
               
                   
                   
                 TAACTAATCCATATTAGATGGGGTTAATTAATATCAGATGGGACAAGTAAGGGCTAAT 
               
               
                   
                   
                 AAGATTATAGGCCACCAAGTAGATTTCTGTCTAGCTCTTATAGAGATTGAGTTTATTG 
               
               
                   
                   
                 GACCTGTTTGATAGGAAGTTTTGGTGTTTGGGATGATTAAAACTGAAGTTCCTATTTA 
               
               
                   
                   
                 TTGAATTATACCTATTTATATTATTTCATATCAGTGGTCCACATGCAAGTGAGGCTTCT 
               
               
                   
                   
                 GAGACAGAGTTTGAGTTCTCTCTTCAACTACCATAACACTTAACCTGTATCTTTTTTTT 
               
               
                   
                   
                 TTTTTTTTTTTTTAGACAGGAGTCTCGCTCTGTCACTCAGGCTGGAGTGTAGTGGTAT 
               
               
                   
                   
                 GATCTCGGCTCACTGTAACCTCTGCCTCCTGGATTCAAGCAGTTCTCCATGTCTCAG 
               
               
                   
                   
                 CCTCCCTAGTAGCTGGGATTACAGGCCTGTGCCACCATGCCTGGCTAATTTTTTTTTT 
               
               
                   
                   
                 GTATTTTTAGTAGAGACGGGGTTTTACCACGTTGGCCAGGCTGGTCTCGAACTCTTG 
               
               
                   
                   
                 ACCTCGAGCGATCAACTTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAG 
               
               
                   
                   
                 CCACAGCGCCCAGCCGTCTTTTTTTTTAAATAGCAATTTAACACTGTTCACAGTTACT 
               
               
                   
                   
                 CATGTACATGTCATGCCATCTATTACACTGTAAGTTCTGTGAGGGTAGCTGTATCAAA 
               
               
                   
                   
                 TTTATCTAACTCTCTCTAGTATGCATGACATAGTAAGTATTCAATAAATATTTGCATAT 
               
               
                   
                   
                 TAGTGATAAGGATACAGGTTCTGAATAGTGGGTCCTTACCATTTAAGAATTAGTATTT 
               
               
                   
                   
                 GATGGCCGGGCGGGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGG 
               
               
                   
                   
                 CGGGCGGATCATGAGATCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAATCC 
               
               
                   
                   
                 CGTCTTTACAAAAAAAATACAAAAGAATTAACCAAGTGTGGTGGTGGGTGCCTGTAG 
               
               
                   
                   
                 TCCCAGCTACTGCTTTGTGAGGCTGAGGCAGGCAGATCACCTGAGGTGGGAAATTC 
               
               
                   
                   
                 AAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGC 
               
               
                   
                   
                 CGGGCGTGGTGGCGCATGTCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAG 
               
               
                   
                   
                 AATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAGGATCGCGCCACTGCA 
               
               
                   
                   
                 CTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAT 
               
               
                   
                   
                 TAGTATTTGATATTTGATCATTAAATATGAATTAAGAGGACTTAGACTTTTTGTTAAAT 
               
               
                   
                   
                 GTCAAGCTGGGAAAAGTTGTCATTTAAATGAATTGCCTCTTATTTAATTTCGTCTGAT 
               
               
                   
                   
                 GATACATTTTGTTTTTATTTTGTAAAAAATTATTTTTTTTCTTTTTGGAGACAGGGTCTT 
               
               
                   
                   
                 GCTCTGTTGCCCAGGCTGGTCACAAACTCCTGACCTCAAGCAATCCTCCTGCCTTAG 
               
               
                   
                   
                 CCTCCCAAAATGCTGGGATTACAGGCGTGACGACCTCGCCCGGCCTTGTATTATGAT 
               
               
                   
                   
                 ACATTTTGAACAACTACAAGTAGACTTGGTATAATGAACCTGCACGTACCCATTGCCA 
               
               
                   
                   
                 AGTTCTGACAACTGTCTGTCTATAGCCAATTATGCATTTCTTAAATTAGAACCCCCCC 
               
               
                   
                   
                 AATATACCCAAATATATATATATGTGTGCATATATATAGTAAGTTGTAACAAAGTTGTG 
               
               
                   
                   
                 AATTCATACCTGAAGTATCTCAAGTGATGCAAGTTTTATGAATTTTTGTTTATGCCTTT 
               
               
                   
                   
                 TGGGAAGAGTTGTATTGACAAATTTTTTATGCTTAAAGTAAACCATAAATCAAAAAAAT 
               
               
                   
                   
                 AAAATCTAGGATGCAATAAAACAAAACAACTTCTTGACATAAGTATGGTATGTAAATC 
               
               
                   
                   
                 TGTTTTGATTGGAAATCAATTTGTTATATTGCCAGAATTCCTGTTTTAGAATACATCTC 
               
               
                   
                   
                 TGCTGATCTGTCTGTATTCTTAGACTGCATATCTGGGATGAACTCTGGGCAGAATTCA 
               
               
                   
                   
                 CATGGGCTTCCTTTGAAATAAACAAGACTTTTCAAATTCTTAGTCGATCTGCAGAACC 
               
               
                   
                   
                 TGTAGCCAGGCACTGAACCATTTTGATAGATGCAGTAATCGTTGCAAGTGTATATTTC 
               
               
                   
                   
                 AAGGGAGTTCTGGCTGGGTCCTAGTTTATGCTTGTGGCAGAAGCAGTGAGTAACTG 
               
               
                   
                   
                 GGAGGAAGTTGGTGAGTAAGCTTCAAGGAAGAAGTCATTTTTAGTACTCTGGATCTT 
               
               
                   
                   
                 CCTGATTTTAAAGCACTACAAAATGGTGCATTTTCATTCTTGTCAAGTGATAACAGAT 
               
               
                   
                   
                 ATATTCTGATGAGCCTGAAATGAATATATATTGTATCATTTTTATAATATCTAGCAAGG 
               
               
                   
                   
                 TTTGTATTTTCCTAGAACTTGAACTAAATTTCAGTTCATAAAATTTATAAAATACTTAGT 
               
               
                   
                   
                 TGTTGTAAAATATTTTTGGAATGTTCACATAGGTGACACACAAATGTCCCATTTTCATT 
               
               
                   
                   
                 CTTTCTATAGTAAATATGTTCTGATATGTGAAGGTTTAGCAGATGCATCAGCATTTAAT 
               
               
                   
                   
                 CCTAGAGGATCTGGCATAATCTTTTCCCCCAAGAATAGAAATTTTTTCTGCTTATGAA 
               
               
                   
                   
                 AGTAGTACATGTTTCTTTAAAAACAAATCAATATTGACTTCTGCCTGCTGTATAGCACT 
               
               
                   
                   
                 ATGCCTCCACCTGGCCATGACCAGGGGCATGTCCTGGTCCACCTACCTGAAAATGT 
               
               
                   
                   
                 TTGCAACCAGCCTCCTGGCCATGTGCACAGGGGCTGAAGTTGTCCCACAGGTATTA 
               
               
                   
                   
                 CGGGCCAACCTGACAATACATGAAGTTCCACCAAAGTCTGAGAACTCAGAACTGAGC 
               
               
                   
                   
                 TTTGGGGACTGAAAGACAGCACAAACCTCAAATTTCTCAGCACTGGAAACCTCAAAA 
               
               
                   
                   
                 TATAACTGAATTCCATAAATAAGATTTTAAGTCTTAAATATGTATTTTTAAATGTATTAA 
               
               
                   
                   
                 AAGTCAAGCTGCTTGTATTTAAGCACCTAATACAATGCTTAGGTTGTAAAAGGAGATG 
               
               
                   
                   
                 CTCAATAGGTACTAACTGATATATTGAGATTTAATTATGGTTTGACCAATATTTATTGG 
               
               
                   
                   
                 AAACCGCCAAAGCTTAAATCATCAGCTTCTTGAATGTGATTTGAAAGGTAATTTAGTA 
               
               
                   
                   
                 TTGAATAGCATGTGAGCTAGAGTATTTCATTCTTTCTGGTTTATTTCTTCAAATAGACT 
               
               
                   
                   
                 TTGAATATAATGGTGAATGGGTATTATAAATTAACTAATAAAAATGACATTGAAAATGA 
               
               
                   
                   
                 AAAAATATATATATTAAAGTGTAGAAAGTGACCAGGCGTGGTGGCTCACACCTGTAAT 
               
               
                   
                   
                 CCAAGCACCTTGGGAGGCTGAGGCAGGAGGATCTCTTGATCCCAGGAGTTCAAGAC 
               
               
                   
                   
                 CAGCCTGGGCAACATAGCGAGACTTCGTCTCTAAAAAAAAAAAAGAGAGAGAAAAAA 
               
               
                   
                   
                 ATTTTTTTTATTTAAAAAAAGTGTAGAAAGTGTCAAGACCCCACTTCTTACCATTATTT 
               
               
                   
                   
                 GGTATATTTCTCTATACCCACCCACCCTTCCTCCTTACTCCCTCCCTCCCTTCCCAAT 
               
               
                   
                   
                 CTTTTTATCTTTTTGTATTCTGATTTTTTGTTTGTATATTTTGCTTTAATTTAATGTATCC 
               
               
                   
                   
                 TTTAAAAATTTCCCATACATTTTATATGTATATATAAAAACGCATGCTGCCAAAGATAA 
               
               
                   
                   
                 TTTATAAGAAAGACCATTGAATTTTTTTAAAAGTGATATATATTCATTGAAAAAAATTTA 
               
               
                   
                   
                 GAATATATAGCAAAGCAATAAAGAACTAAATAAAATTGCTGTAACTCCTCTTTCAAAG 
               
               
                   
                   
                 ATAAGTGCTTTTATGATTTTGTTGTATTTTTTTCTGTATATAGGTACATATATAGTATTT 
               
               
                   
                   
                 ATAAAGCTGTACTCATAGTACATTTTCACATCACAGGTACCATATCAGTGTTATTAAAT 
               
               
                   
                   
                 ATTTTGTATGCCAGGGGCTAGACATACCAAGACAACCAATATGTGGTTCTACTTAAAT 
               
               
                   
                   
                 AATATTAGAGTATCTTTTATGATGACACTTCATGAGTTGACTATAATAATCTTAGACTT 
               
               
                   
                   
                 CTAAGAGTTTGGGTTTTCAAAAGATCACTTAGCTTTTTTGGGTGATTTTTCCCCCTTA 
               
               
                   
                   
                 CTGTGAGATGAGAGAGGCTGTTTGGATTTGGGATTGGGGTAGCGGGGACAGCAACT 
               
               
                   
                   
                 TTTCTTTTCTTTTTCTTTTTTATTTTGAGGTAGGGTATTGCTGTGTCACCCAGGCTGGA 
               
               
                   
                   
                 GTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCCACCTCCCGGGCTCAGGTGATC 
               
               
                   
                   
                 CTCCTGCTTCAGCCTCCCAGTAACTGGGACTACAGGCGCGTGCCACATGCCTGGCT 
               
               
                   
                   
                 AATTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCTAAC 
               
               
                   
                   
                 TCCTGACCTCAGGTGATACGCCCACCTGGGCCTCCCAAAATACTGGGATTACAGGC 
               
               
                   
                   
                 ATGAGCCGCTGCATCAGCCAGCAGTTTTTCTTGTGGTTTTTTTTGTTTGTTTTGTTTTG 
               
               
                   
                   
                 TTTTGTTTTTGAGATAGGGTCTTACTCTGTTGTCCACGCTGGAGTGCTGTGGTATGAT 
               
               
                   
                   
                 CGTAGCTCACTGCAGCCTCAAACTCCTGGGCTCAAGTGATTCCTTCTGCCTCCGCCT 
               
               
                   
                   
                 CCCGAGTAGCTGGGACTACAGGTATGCACCACCATACCTGGCAAATTTTTACAAAGT 
               
               
                   
                   
                 TTTTTGTAGGGACGGGGTCTTGCTACATTCCCCATGTCGGTCTTGAACTCCTGGCCT 
               
               
                   
                   
                 CAAGCAACTCTCCTGTCTCAGCCTCCCAAAGCACTGGGATTACAAGTGTGAGCCACC 
               
               
                   
                   
                 ACACCATGCCAGTTTTTCCTGTTCAGTGTGATATTTTATCTTGTTAGACTACAGTGTG 
               
               
                   
                   
                 TTAAAACTTGTTTTACTAAATTTTCAAACATACTCAAAAGTGGAGAGAATAGTATAATG 
               
               
                   
                   
                 AATACCCGTATGTTCATCACCCATGTTTAGAATATTATTAAATATAAAGATTTTGCTGC 
               
               
                   
                   
                 GTTTGTCTTAGCTCTTTAAAATTTTTCTTTTTCTCTTTGTGACCTAAAGGAAATTCCATA 
               
               
                   
                   
                 TCTTATCACTTTACTTCTACATTCTTGACTAAGATGACTAAGACATATAGTTACATGGT 
               
               
                   
                   
                 TTTTTGTTTTGTTTTTGTTTTTTAAAGACGAAATCTCGCTCTTGTCCCCCAGGCTGGA 
               
               
                   
                   
                 GTGCAATGGTGCCATCTCAGCTCAGTGCAACCTCTGCCTTCTGGGTACAAGCGATTC 
               
               
                   
                   
                 TCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCTCCTGCCACCACGCCTGGC 
               
               
                   
                   
                 TAATTTTTGTATTTTTAGTAGAGACGGCGGGGGGAGGTTTCACCATGTTGACAAGGC 
               
               
                   
                   
                 TGGTCTGGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTG 
               
               
                   
                   
                 GGATTACAGGCGTGAGCCACCGCGCCCAGCCTGTTTTTTTGTTTGTGTGTTTTGTTT 
               
               
                   
                   
                 TTTTTGAGACAGAGTCTTGCTCTGTTTCCCAGGCTGGAGTGAAGTGGTGCCATCTCA 
               
               
                   
                   
                 GCTCAGAGACAGAGTCTTGCTCTGTTTCCCAGGCTGGAGTGAAGTGGTGCCATCTT 
               
               
                   
                   
                 GGCTCACTGCAACCTTCACCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCA 
               
               
                   
                   
                 AGTAGCTGGGACTACAGGCATGTGTCACCACACCCGGCTAATTTTTTTGTATTTTTAG 
               
               
                   
                   
                 TAGAGACGGGATTTCACCGTGTTGCCCAGGCTGGTCTCGAACTCCTGAGCTCAGGC 
               
               
                   
                   
                 AGTCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGTGTGAACCAACCCGC 
               
               
                   
                   
                 CCGGCCTGTTGTTTTCTTACATAATTCATTATCATACCTACAAAGTTAACAGTTACTAA 
               
               
                   
                   
                 TATCATCTTACACCTAAATTTCTCTGATAGACTAAGGTTATTTTTTAACATCTTAATCCA 
               
               
                   
                   
                 ATCAAATGTTTGTATCCTGTAATGCTCTCATTGAAACAGCTATATTTCTTTTTCAGATT 
               
               
                   
                   
                 AGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTG 
               
               
                   
                   
                 AGGATTTGGAAAGGGTGTTTATTCCTCATGGACTAATTATGGACAGGTAAGTAAGAT 
               
               
                   
                   
                 CTTAAAATGAGGTTTTTTACTTTTTCTTGTGTTAATTTCAAACATCAGCAGCTGTTCTG 
               
               
                   
                   
                 AGTACTTGCTATTTGAACATAAACTAGGCCAACTTATTAAATAACTGATGCTTTCTAAA 
               
               
                   
                   
                 ATCTTCTTTATTAAAAATAAAAGAGGAGGGCCTTACTAATTACTTAGTATCAGTTGTG 
               
               
                   
                   
                 GTATAGTGGGACTCTGTAGGGACCAGAACAAAGTAAACATTGAAGGGAGATGGAAG 
               
               
                   
                   
                 AAGGAACTCTAGCCAGAGTCTTGCATTTCTCAGTCCTAAACAGGGTAATGGACTGGG 
               
               
                   
                   
                 GCTGAATCACATGAAGGCAAGGTCAGATTTTTATTATTATGCACATCTAGCTTGAAAA 
               
               
                   
                   
                 TTTTCTGTTAAGTCAATTACAGTGAAAAACCTTACCTGGTATTGAATGCTTGCATTGTA 
               
               
                   
                   
                 TGTCTGGCTATTCTGTGTTTTTATTTTAAAATTATAATATCAAAATATTTGTGTTATAAA 
               
               
                   
                   
                 ATATTCTAACTATGGAGGCCATAAACAAGAAGACTAAAGTTCTCTCCTTTCAGCCTTC 
               
               
                   
                   
                 TGTACACATTTCTTCTCAAGCACTGGCCTATGCATGTATACTATATGCAAAAGTACAT 
               
               
                   
                   
                 ATATACATTTATATTTTAACGTATGAGTATAGTTTTAAATGTTATTGGACACTTTTAATA 
               
               
                   
                   
                 TTAGTGTGTCTAGAGCTATCTAATATATTTTAAAGGTTGCATAGCATTCTGTCTTATGG 
               
               
                   
                   
                 AGATACCATAACTGATTTAACCAGTCCACTATTGATAGACACTATTTTGTTCTTACCGA 
               
               
                   
                   
                 CTGTACTAGAAGAAACATTCTTTTACATGTTTGGTACTTGTTCAGCTTTATTCAAGTGG 
               
               
                   
                   
                 AATTTCTGGGTCAAGGGGAAAGAGTTTATTGAATATTTTGGTATTGCCAAATTTTCCT 
               
               
                   
                   
                 CTAAGAAGTTGAATCATTTTATACTCCTGATGTTATATGAGAGTACCTTTCTCTTCACA 
               
               
                   
                   
                 ATTTGTCTCTTTTTTTTTTTTTTTTGAGACAAGGTCTCTGTTGCCCAGGCTGGGGTGC 
               
               
                   
                   
                 AGTGCAGCAGAATGATCACAGTTCACTGCAGTCTCAACCTCCTGGGTTCAAGCGATC 
               
               
                   
                   
                 CTTCCACCTCAGCCTCCTGAGTAGCTGGGACTATAGGTGTGCGCCACCACTCCCAG 
               
               
                   
                   
                 CTAATATTTTTATTTTGTAGAAACAGGGTTCGCCATGTTACCCAGCCTCCCAAAGTGC 
               
               
                   
                   
                 TGGGATTACAGGCATGAGCCACTGGCCCAGTTTCTACAGTCTCTCTTAATATTGTATA 
               
               
                   
                   
                 TTATCCAGAAAATTTCATTTAATCAGAACCTGCCAGTCTGATAGGTGAAAATGGTATC 
               
               
                   
                   
                 TTGTTTTTATTTGCATTTAAAAAAAATTATGATAGTGGTATGCTTGGTTTTTTTGAAGG 
               
               
                   
                   
                 TATCAAATTTTTTACCTTATGAAACATGAGGGCAAAGGATGTGATACGTGGAAGATTT 
               
               
                   
                   
                 AAAAAAAATTTTTAATGCATTTTTTTGAGACAAGGTCTTGCTCTATTGTCCAGGCTGG 
               
               
                   
                   
                 AGTGCAGTGGCACAATCACAGTTCACTCCAGCCTCAACATCCTGCACTAAAGTGATT 
               
               
                   
                   
                 TTCCCACCTCACCTCTCAAGTAGCTGGGACTACAGGTACATGCTACCATGCCTGGCT 
               
               
                   
                   
                 AATTTTTTTTTTTTTGCAGGCATGGGGTCTCACTATATTGCCCAGGTTGGTGTGGAAG 
               
               
                   
                   
                 TTTAATGACTAAGAGGTGTTTGTTATAAAGTTTAATGTATGAAACTTTCTATTAAATTC 
               
               
                   
                   
                 CTGATTTTATTTCTGTAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGG 
               
               
                   
                   
                 AGGCCATCACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGA 
               
               
                   
                   
                 CCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACT 
               
               
                   
                   
                 GTAGATTTTATCAGACTGAAGAGCTATTGTGTGAGTATATTTAATATATGATTCTTTTT 
               
               
                   
                   
                 AGTGGCAACAGTAGGTTTTCTTATATTTTCTTTGAATCTCTGCAAACCATACTTGCTTT 
               
               
                   
                   
                 CATTTCACTTGGTTACAGTGAGATTTTTCTAACATATTCACTAGTACTTTACATCAAAG 
               
               
                   
                   
                 CCAATACTGTTTTTTTAAAACTAGTCACCTTGGAGGATATATACTTATTTTACAGGTGT 
               
               
                   
                   
                 GTGTGGTTTTTTAAATAAACTCCTTTTAGGAATTGCTGTTGGGACTTGGGATACTTTTT 
               
               
                   
                   
                 TCACTATACATACTGGTGACAGATACCCTCTCTTGAGCTACATCGGTTTGTGGGGAG 
               
               
                   
                   
                 TCAAAAGTCCTTTGGAGCTAGGTTTGACAAATAAGGTGGGTTAACACTTGTTTCCTAG 
               
               
                   
                   
                 AAAGCACATGGAGAGCTAGAGTATTGGCGAATTGAAGAAATCCCCCTTTTTTTTTAAC 
               
               
                   
                   
                 ACACTTAAGAAAGGGGACTGCAGGTATACTCAAGAGAGTAAGTCGCACCAGAAACC 
               
               
                   
                   
                 ACTTTTGATCCACAGTCTGCCTGTGTCACACAATTGAAATGCATCACAACATTGACAC 
               
               
                   
                   
                 TGTGGATGAAACAAAATCAGTGTGAATTTTAGTAGTGAATTTCATTCATAATTTGATCG 
               
               
                   
                   
                 TGCAAACGTTTGATTTTTATTACTTTAGACTATTGTTTCTGATTTTATGTTGGGTTGGT 
               
               
                   
                   
                 ATTTCCTGTGAGTTACTGTTTTACCTTTAAAATAGGAATTTTTCATACTCTTCAAAGAT 
               
               
                   
                   
                 TAGAACAAATGTCCAGTTTTTGCTGTTTCATGAATGAGTCCTGTCCATCTTTGTAGAA 
               
               
                   
                   
                 ACTCGCCTTATGTTCACATTTTTATTGAGAATAAGACCACTTATCTACATTTAACTATC 
               
               
                   
                   
                 AACCTCATCCTCTCCATTAATCATCTATTTTAGTGACCCAAGTTTTTGACCTTTTCCAT 
               
               
                   
                   
                 GTTTACATCAATCCTGTAGGTGATTGGGCAGCCATTTAAGTATTATTATAGACATTTT 
               
               
                   
                   
                 CACTATCCCATTAAAACCCTTTATGCCCATACATCATAACACTACTTCCTACCCATAA 
               
               
                   
                   
                 GCTCCTTTTAACTTGTTAAAGTCTTGCTTGAATTAAAGACTTGTTTACGGTATCGATAA 
               
               
                   
                   
                 GCTTGATATCAAAACGCCAACTTTGACCCGGAACGCGGAAAACACCTGAGAAAAACA 
               
               
                   
                   
                 CCTGGGCGAGTCTCCACGTAAACGGTCAAAGTCCCCGCGGCCCTAGACAAATATTA 
               
               
                   
                   
                 CGCGCTATGAGTAACACAAAATTATTCAGATTTCACTTCCTCTTATTCAGTTTTCCCG 
               
               
                   
                   
                 CGAAAATGGCCAAATCTTACTCGGTTACGCCCAAATTTACTACAACATCCGCCTAAAA 
               
               
                   
                   
                 CCGCGCGAAAATTGTCACTTCCTGTGTACACCGGCGCACACCAAAAACGTCACTTTT 
               
               
                   
                   
                 GCCACATCCGTCGCTTACATGTGTTCCGCCACACTTGCAACATCACACTTCCGCCAC 
               
               
                   
                   
                 ACTACTACGTCACCCGCCCCGTTCCCACGCCCCGCGCCACGTCACAAACTCCACCC 
               
               
                   
                   
                 CCTCATTATCATATTGGCTTCAATCCAAAATAAGGTATATTATTGATGATGTTT 
               
               
                   
               
               
                 123 
                 HDAdCD19BiTE 
                 AAACATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGGGGGT 
               
               
                   
                   
                 GGAGTTTGTGACGTGGCGCGGGGCGTGGGAACGGGGCGGGTGACGTAGGTTTTAG 
               
               
                   
                   
                 GGCGGAGTAACTTGTATGTGTTGGGAATTGTAGTTTTCTTAAAATGGGAAGTGACGT 
               
               
                   
                   
                 AACGTGGGAAAACGGAAGTGACGATTTGAGGAAGTTGTGGGTTTTTTGGCTTTCGTT 
               
               
                   
                   
                 TCTGGGCGTAGGTTCGCGTGCGGTTTTCTGGGTGTTTTTTGTGGACTTTAACCGTTA 
               
               
                   
                   
                 CGTCATTTTTTAGTCCTATATATACTCGCTCTGCACTTGGCCCTTTTTTACACTGTGAC 
               
               
                   
                   
                 TGATTGAGCTGGTGCCGTGTCGAGTGGTGTTTTTTTAATAGGTTTTCTTTTTTACTGG 
               
               
                   
                   
                 TAGGCGCGCCGTCGACGCTTATTACCCTGTTATCCCTACTAGCTAGCCGACGCGTT 
               
               
                   
                   
                 GGGAGCTCTCCGGATCCAAGCTTATCGATTTCGAACCCAAATGGATCTACCACATTT 
               
               
                   
                   
                 GTAGAGGTTTTACTTGCTTTAAAAAACCTCCCACACCTCCCCCTGAACCTGAAACATA 
               
               
                   
                   
                 AAATGAATGCAATTGTTGTTGTTAACTTGTTTATTGCAGCTTATAATGGTTACAAATAA 
               
               
                   
                   
                 AGCAATAGCATCACAAATTTCACAAATAAAGCAATAGCATCACAAATTTCACAAATAA 
               
               
                   
                   
                 AGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATC 
               
               
                   
                   
                 ATGTCGAGCTAGCTAGTCAGGACTTCAGTTCCAGCTTTGTGCCGGCTCCGAAGGTC 
               
               
                   
                   
                 AGCGGGTTGCTAGACCATTGCTGACAGTAATATGTGGCGGCATCCTCGGCTTCCATA 
               
               
                   
                   
                 GAGCTGATTGTCAGGCTGTAGCTGGTGCCAGATCCAGATCCGCTGAATCTGTAGGG 
               
               
                   
                   
                 CACGCCGGAGGCCACTTTGCTTGTGTCGTAGATCCACCGCTTGGGGCTTGTGCCAG 
               
               
                   
                   
                 ACTTCTGCTGATACCAGTTCATGTAGGACACGCTGCTGCTGGCTCTGCATGTCATGG 
               
               
                   
                   
                 TCACTTTCTCGCCTGGGGAAGCGCTCATGATGGCGGGGCTTTGTGTCAGCTGAATA 
               
               
                   
                   
                 TCGGAGCCACCACCACCGCTTCCACCACCACCTGAACCGCCTCCGCCACTAGAAAC 
               
               
                   
                   
                 TGTCAGGGTTGTGCCCTGGCCCCAGTAATCCAGACAGTAGTGGTCGTCGTAGTACC 
               
               
                   
                   
                 GGGCACAATAGTACACAGCGCTATCTTCAGAGGTCAGGCTGGACAGCTGCATGTAG 
               
               
                   
                   
                 GCGGTAGAGCTGCTCTTGTCGGTGGTCAGTGTGGCCTTGTCCTTGAACTTCTGGTT 
               
               
                   
                   
                 GTAATTGGTGTAGCCCCGGCTGGGGTTGATGTAGCCGATCCATTCCAGTCCTTGGC 
               
               
                   
                   
                 CAGGCCTCTGCTTGACCCAGTGCATGGTGTACCGGGTGAATGTGTAGCCGCTGGTC 
               
               
                   
                   
                 TTGCAGGACATCTTCACAGAGGCGCCAGGTCTAGCCAGTTCGGCGCCAGACTGTTG 
               
               
                   
                   
                 CAGCTTGATATCGGATCCACCACCTCCGCCAGAAGAAACTGTCACGCTGGTGCCCT 
               
               
                   
                   
                 GGCCCCAATAGTCCATAGCGTAGCTGCCGCCGTAGTAGTAGTGCTTGGCGCAATAG 
               
               
                   
                   
                 TAGATGGCGGTGTCGTCGGTCTGCAGGCTGTTCATCTTCAGGAACACCTGGCTCTT 
               
               
                   
                   
                 GGAGTTGTCCTTGATGATGGTCAGCCGGGACTTCAGGGCGCTGTTGTAGTAGGTTG 
               
               
                   
                   
                 TCTCGCTGCCCCAGATCACTCCCAGCCATTCCAGGCCTTTCCGAGGAGGCTGTCTG 
               
               
                   
                   
                 ATCCAGGACACGCCATAATCAGGCAGGGACACTCCGCTGACGGTACAGGTCACGCT 
               
               
                   
                   
                 CAGAGATTGAGATGGGGCCACCAGGCCAGGGCCAGACTCTTGCAGTTTCACTTCAG 
               
               
                   
                   
                 ATCCTCCGCCACCAGAACCTCCGCCTCCGCTTCCTCCGCCGCCTGTGATTTCCAGC 
               
               
                   
                   
                 TTGGTGCCTCCGCCAAAGGTGTAAGGCAGGGTGTTGCCTTGCTGGCAGAAGTAGGT 
               
               
                   
                   
                 AGCGATATCCTCTTGTTCCAGGTTGCTGATTGTCAGGCTGTAGTCGGTGCCAGAGCC 
               
               
                   
                   
                 GCTGCCAGAAAATCTGCTTGGCACGCCGCTGTGCAGTCTGCTGGTGTGGTAGATCA 
               
               
                   
                   
                 GCAGCTTCACGGTGCCGTCGGGTTTCTGCTGATACCAGTTCAGGTACTTGCTGATGT 
               
               
                   
                   
                 CCTGGCTGGCTCTACAGCTGATGGTCACTCTATCGCCCAGAGAGGCAGACAGGCTG 
               
               
                   
                   
                 CTGGTGGTCTGGGTCATCTGAATATCGCTGTGGGCGCCTGTGGCAGCTCCCACAAG 
               
               
                   
                   
                 GAACAGGATGCGCCAGATCCAATCCATGGTGGCCCTCCTTCGCCGGTGATCTCAGC 
               
               
                   
                   
                 TGTAGGAAAGAGAAGAAGGTTAGTAGTCGACGTGTCCCTCTCGATGAATCTAAGTAT 
               
               
                   
                   
                 CAATTGTGAGCGCTCACAAGTCAACACTCTTTTTGATAAATCTAGTAGATATCACTTA 
               
               
                   
                   
                 CGTAGGCGCCGGTCACAGCTTGGATCTGTAACGGCGCAGAACAGAAAACGAAACAA 
               
               
                   
                   
                 AGACGTAGAGTTGAGCAAGCAGGGTCAGGCAAAGCGTGGAGAGCCGGCTGAGTCT 
               
               
                   
                   
                 AGGTAGGCTCCAAGGGAGCGCCGGACAAAGGCCCGGTCTCGACCTGAGCTTTAAA 
               
               
                   
                   
                 CTTACCTAGACGGCGGACGCAGTTCAGGAGGCACCACAGGCGGGAGGCGGCAGAA 
               
               
                   
                   
                 CGCGACTCAACCGGCGTGGATGGCGGCCTCAGGTAGGGCGGCGGGCGCGTGAAG 
               
               
                   
                   
                 GAGAGATGCGAGCCCCTCGAAGCTTCAGCTGTGTTCTGGCGGCAAACCCGTTGCGA 
               
               
                   
                   
                 AAAAGAACGTTCACGGCGACTACTGCACTTATATACGGTTCTCCCCCACCCTCGGGA 
               
               
                   
                   
                 AAAAGGCGGAGCCAGTACACGACATCACTTTCCCAGTTTACCCCGCGCCACCTTCTC 
               
               
                   
                   
                 TAGGCACCGGTTCAATTGCCGACCCCTCCCCCCAACTTCTCGGGGACTGTGGGCGA 
               
               
                   
                   
                 TGTGCGCTCTGCCCACTGACGGGCACCGGAGCGATCGCAGATCCTTCGATAGAGAA 
               
               
                   
                   
                 ATGTTCTGGCACCTGCACTTGCACTGGGGACAGCCTATTTTGCTAGTTTGTTTTGTTT 
               
               
                   
                   
                 CGTTTTGTTTTGATGGAGAGCGTATGTTAGTTACGATTCACACAAAAAACCAACACAC 
               
               
                   
                   
                 AGATGTAATGAAAATAAAGATATTTTATTGCGGCCGCTCGAGTCTAGAGGACATGCC 
               
               
                   
                   
                 ATGGTCGTATTACCCTGTTATCCCTAACTGCATGCGACGTCGGCGCGCCATCGAATT 
               
               
                   
                   
                 CCTGCAGCCCGGGGGATCCCTTTGTTGATTTTTTCCACATAGATTATTTTTGACTGTT 
               
               
                   
                   
                 TTGGCACTTTATATAAATGGAATCATATAGTAAATATATACATGTATATATGTATATATA 
               
               
                   
                   
                 CACTATATATGTATATATATAGTGTATATATATACATGTATATATGTATATTTACATATA 
               
               
                   
                   
                 TACTGTATATATGTATATTTACATATATACTGTATATATGTATATATACACGTATATACT 
               
               
                   
                   
                 GTATATATACAGTATATACTGTATATATATACTGTATATATGTGTATATATATATACAGT 
               
               
                   
                   
                 ATATATACAGTATACATATATATACATGTATATATACACAGTATATATACATGTATATAT 
               
               
                   
                   
                 ACACAGTATATATACATGTATATATACACAGTATATATACATGTATATATACACAGTAT 
               
               
                   
                   
                 ATATACACTGTATATATGTATATATATACTGTGTATATATATACAGTATATATACAGTAT 
               
               
                   
                   
                 ATATATACATGTATATGTATATATATACTGTATATATGTGTATATATACGTATATATACT 
               
               
                   
                   
                 GTATATATATATAGACACTTTTGTGTCTGGCTTCTTGCTCTCATCATAAAGCACTTGAA 
               
               
                   
                   
                 ATCCATCCATGTTGTAGCTGGTATCAGTAGCTAGTTTCTTTTCATTGCTGAGAAGTAT 
               
               
                   
                   
                 CACTTTTTATTGATGAGTAGTTTTACATTGTATGAACATGCCCGAGTTTGTTTATGCAT 
               
               
                   
                   
                 TCTACTAATAGACACCTGGGCTGTTTGCAGTTTTTGGCTATTACAAAGAAAATTTCTA 
               
               
                   
                   
                 TATTTTTTTCCAACTTTTATTTTAGGTTCAGCGGGTACATGGGCAGGTTTGTTACATC 
               
               
                   
                   
                 GGTAAATTGCATGTCACTGGGGTTTGGTGTACAGATTATTTCACCACCCAGGTAATA 
               
               
                   
                   
                 AGCATAGTACCTGATAGGCAGGTTTTTGATCCTCACCCTCCTCCCTCAAGTAGGCCC 
               
               
                   
                   
                 CAGTGTCTATTGTTCTATTCCTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTTGCC 
               
               
                   
                   
                 CAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGGTCCACCTCCAGGGTT 
               
               
                   
                   
                 CAAGCGATTCTACTGCCGCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCACCAC 
               
               
                   
                   
                 CACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCCAG 
               
               
                   
                   
                 GATGGTCTCGAACTCCTCACCTCAGGTGATCCGCCCGCTTCGGCCTCGCAAAGTAC 
               
               
                   
                   
                 TGGGATTACAGGCGTGAGCCACGGTGCCTGGCCTATGGTTCCATTCTTTGTGTACAC 
               
               
                   
                   
                 GTGTACTCAGTGTTTAGCTTCCACTTGTAAGTGAAAACATGCAGTATTTGGTTTTCTG 
               
               
                   
                   
                 AAATTCTTGTCTTCATCTTTTTGTAGACAATCCACTACTTTTATTTTTAAATATTAGGAA 
               
               
                   
                   
                 CAATAGCCTCTGTGTGTCCTGAATTGCAATGTTTTTTCTCTGATTTTGCTGCTCATCTT 
               
               
                   
                   
                 GTAACCTGTATGGTGTTTTTCTGTGTGCAAGCTTTTTACTTTACGTGGGCAATTTTAT 
               
               
                   
                   
                 CATTCTTTTCTTTTATGGTTTCTGGGTTTCATGTCATGATTGGAGAAGCTTGATCTACC 
               
               
                   
                   
                 CTGATACTATAAAAATATCCACCTTGGCTTTTTTTTTTTTTTTTAGATGGATTTTCACTC 
               
               
                   
                   
                 TTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACCACAACCTCTGCCT 
               
               
                   
                   
                 CCCAGGTTCAAGTGATTCTCCTGCCTCGGCCTCCTGAGTAGCTGGGATTACAGGCA 
               
               
                   
                   
                 TGCGCCACCACGCTCAGCTAATTTTGTATTTTTAGTAGAGACAGGATTTCACCATGTT 
               
               
                   
                   
                 GGTCAGGCTGGTCTTGAACTCCCCACCTCAGGTGATCTGTCTGCCTCGGCCTCCCA 
               
               
                   
                   
                 AAGTGCTGGGATTACAGGCGTGACCCACCACACCTGGCCCACGTTGTTTTCTGATA 
               
               
                   
                   
                 GTGTTTTCACGTGTTATTTTTTCTGTCTTACTCTTTGAATCATCTAAATGTATCTTAATG 
               
               
                   
                   
                 TCAGGAGTGAGGTAGAGGACCCAGTTGTTTGGTTTAAATGACTAGCCAGTTTTCCCA 
               
               
                   
                   
                 ACACCAGGTGTTGAACATCCCTCACTGATGTGAGATGCTGCCTTTTTCACAGTCTCA 
               
               
                   
                   
                 ATCCCCATGTGCATTTCTATTTATTTTCCTTCCACTTTATTCACATCTTTTTCAGTATCC 
               
               
                   
                   
                 ACAACCATATTGTTTTAAATAGCTTCATGATATGTTTTAATATTTGGTAGAGCTAGAAC 
               
               
                   
                   
                 CCTTTCTTGGTTCTTTTTCTTTTCTTCTTCTCCTCCTTTTCCTCCTCCTTCTTTCTCCTC 
               
               
                   
                   
                 CTCCTTCTTCTTTCTTTTTAGAAATTTCCTGGCTATTCTTGTTTTGTAGTCTTCCAGAT 
               
               
                   
                   
                 AAATAATTTTGAATCACTTTGTCATGTTCCAGAAAATAATACTGCCAGAATTTTTATTG 
               
               
                   
                   
                 TGATCACAGAAGTTTTACAGATTCATCTGGGGGAAAAAAACCCATCTTCCCAGAATAC 
               
               
                   
                   
                 AGAAAGGGTGAGGGAAAGACAAACATCAAGGACAAGTCTCAGGTTCTGGACTTGGA 
               
               
                   
                   
                 GACCAAGAGGATTTGGGGCATCCGGGAGCAGGGCAGGGAGGTGTGATGGCTGCCT 
               
               
                   
                   
                 TTCACTGAGTAGGAGGATGCCCAGACTTGGGGGAACTATGGAAAGTTTGGTTCAGA 
               
               
                   
                   
                 CTTTCTGAGTTGGAGATGTCTATGCGCAGTCCACAGGGCGAAGCCCTGGAGGTAGA 
               
               
                   
                   
                 GGCCCTCCTTACTGCCTCCCTCATTCAGTCTGAGGTCCATTCTCCACATGGACACTG 
               
               
                   
                   
                 AAGTGACTCAAGGCTTCCCTTGTTGGATCAGGATAGTCTCCAGGGCCCTGGGTGGT 
               
               
                   
                   
                 CTGGGCCTGCCCACCTCCCCATCCCCTCTCCTGCCTGCCCTCCTCTTGCTCACTGG 
               
               
                   
                   
                 ACCCCACCCACCAGCCTCCTTCTATTCCTCCTGACATTTGCACTTGCTGTTCCGTCT 
               
               
                   
                   
                 CTGCTTGGAACATCCTAGCTCTTTGCATGGCTTGCTCCTTCCCATCTTTTAATCTAAG 
               
               
                   
                   
                 CTCAAATATCACTCCTTCAGATATGCCTTTCCCAAATATCCTAGCTAAAGAGAACTGC 
               
               
                   
                   
                 TCCCCACTTCCCACAAGCCCTAGCAAACTGGGACTCTCCTTCTTGCTTTCTTTCTCTC 
               
               
                   
                   
                 TGCCCCTTCTGTGTTTTTTCCATAGACCTTAACTTGTTACTGTTTTATTTGTTGATGTG 
               
               
                   
                   
                 TTTACATCATTTGTCCCCCTGTGATGGTTAGTTTTATGTGTCAACTTGGCTAGGCTGT 
               
               
                   
                   
                 AGGGGCTGTTCGTCAATCAAACACTGATCTATGTGTAGCTGTGAAGGGATTTTGTAG 
               
               
                   
                   
                 CTGTGATTAATAGTTGACTTTAAGTAAGGAAGATTATCCTGGAGAATGTGGGGGAAG 
               
               
                   
                   
                 GGGCAGACCTCAGCCAATCAGTTGAAAGGCCTTAAGAACAAAGCTGAGATTTCCCC 
               
               
                   
                   
                 GAGGAAGAAGAAATTCTGCCTGTGGACTGCAGCATCAGCTCCTGCTTGAGAGGTTC 
               
               
                   
                   
                 CAGGCTGCCCTTCCTGACAGCCTGTCCTATGATTTTGGACTTGCCTTGCCAGGTTTT 
               
               
                   
                   
                 TCCTCTTTCTTGACCCCCCAAAACCATATATATCTCCTGCTGGTTTGTTTCTCTGGTG 
               
               
                   
                   
                 TAATCCTGAGGGATGAACACTCCTCCCTCCCAGTTCACTCTGGGAGAGGTTGGGGA 
               
               
                   
                   
                 TCATGTTTGTCTATTTCCCCATGCCTGGCCCATGCGTGTTTATTGAATCACTGAACAA 
               
               
                   
                   
                 CCACGCATTAGGAAGCCAGTCATATGTGCTTCTTCAGAACCTCATGTCCATTGCCAG 
               
               
                   
                   
                 ATCTCCCTGGCTTTTGTGGCTAGAGGACAAGTGAGAGATAGTAGCTTACCCACAGAC 
               
               
                   
                   
                 CTTGGCCCTGAGGCCCCCAGGGGCCTGAGCCTGCTGTAAGGGAGGAGGGAGCCCC 
               
               
                   
                   
                 TGAGGTCTCACACACCTCCCTGGGGATCTGGCATTTTCCCCTGGGGCTGGCCTCAG 
               
               
                   
                   
                 AGCTGGGCGGGGGCAGATTATGGAGTGGGTTGTAGAGGGAGCACCTCCCCACTAG 
               
               
                   
                   
                 CAATCATGGTTTTTTCTGCGCCTCTCATAGGGAGGCCTACAGGCCTCCACCTTCAGC 
               
               
                   
                   
                 TCTTCAGGAGCCACAGGCAGCTGAGTGACTTCTGCATCACAGTCTTCTCAGAGACAA 
               
               
                   
                   
                 ACTTGCAGTAAGAAAGAGGGGCCCGTGAGGGACCCCAGAGAAGGCTGTTGTCAAAG 
               
               
                   
                   
                 CAGGATGAGAGTGAACTCTTCCATGGGGGACACCCAGCGTCTCCAAGCTCTTTTATG 
               
               
                   
                   
                 CTGTCTTCAAGGGGTCTAGAGAGCTTCAGCCCAACATGAGACCCAGTCCAGCAGCA 
               
               
                   
                   
                 TTTCCCTGCGAAGTGAAAGTTAGGACCCTGACTAGATACACCACGCTGACCTCAGCC 
               
               
                   
                   
                 AGAATATCAAGATGCTGAGGCGCTGAGATGCTGGGATGCTAAGGTGCTAAGGTGCT 
               
               
                   
                   
                 GGGGTGCTGGGGTGCTAGGATGCTGAGGTTTTGTGATACTGGGTCGCTGAGATGCT 
               
               
                   
                   
                 GGGATACTGGGGTGCTGAAGTGCTGGGGTACTGGGGTGTTGCCATGCTGAAATGCT 
               
               
                   
                   
                 GGGGTGTTGGGATGCTGAGGTGCTGGGTTGCTGGGATGCTGGGATAGTCCTTGGAT 
               
               
                   
                   
                 GCTGCGGTGCTGAGATGCTGGTCTGCTGGTCTGCTGGGGTGTTGGGATGCTGGGA 
               
               
                   
                   
                 TTTTGGGATGCTGGAGTGCTGCAGTGCTGCAGTGCTGAGATGCTGGAGTGCTGGGG 
               
               
                   
                   
                 TGCTGGAATACTGTAGTACTGGTGTGCTGGAGCATTGAGATGCTAGGGCACTGGGA 
               
               
                   
                   
                 TGCTAAGGTGCTGAGATGCTGCAGTGCTGGGGTGTTGGGATGCCGAGGTGTTGGG 
               
               
                   
                   
                 ATGCTTAAGTGCTGGGGTGTTGGGATGCTGGGGTGCTGGAACACTATGGTGCTGGG 
               
               
                   
                   
                 GTGCTGGAGTGTTGAGATACTGTAGTGGTGGGATGCTTAAGTGCTGGGGTGCTGGG 
               
               
                   
                   
                 TGTTGGGATGCCTAGGTGCTGGGGTGCCGAGATGCTGGAGTACTAGTGTGCTGGGA 
               
               
                   
                   
                 TGCTGAAGTGCTGGGGTCCTGAGATGCTGCAGTGCTAGGGTGCTGAGATTCTGGGC 
               
               
                   
                   
                 TGCTGGAGTGTTGGGGTGCTGGGATGCTGGAGTGCTGAGATGCTTGGACAATGGG 
               
               
                   
                   
                 GTGCTGGAATACTATGGTGCTGGGGTGCTGGGGTATTGAGATGCTAGGGTACTGGG 
               
               
                   
                   
                 ATGCTGAAGTGCTGAGATCCTGGAGTGCTGGGCTGCTGGGCCACAGGCTCTTGAAT 
               
               
                   
                   
                 CCATTCGTCTGCCCAGGGGAAGAAACCAGAAGATAAAGAGCTAATGAAGGAGCTTT 
               
               
                   
                   
                 GGTTGAGAGGGAGGAAGTAATGGAAGGAGCAACATCTTGTGGAGGAGCAGGAGAG 
               
               
                   
                   
                 AATGGACCTCAGGTTGGGAGAGAGGGCCAGGCTACAGGCCAGAGAGGCAGAAGGA 
               
               
                   
                   
                 TTCCAGCAGAGTGTGGGCTCCAGGAGCCAAGGGGAAACAGGTTTCTGGGAGGAGA 
               
               
                   
                   
                 GAGTCCAGTACTGCTGAAGTGGCAAGTCCGCTGAGGACCAGGAAGCTTCATTTGGC 
               
               
                   
                   
                 TTTATGACCAGGAGGAATTTGGAACTGTGACTAGAGTACTTAGGGGGAAGGAGGCA 
               
               
                   
                   
                 AGACTGGAGCCAGATTGCTCTGGGTTGAGGGGTGAGTGGGAGGTGAAGCAGGGCA 
               
               
                   
                   
                 CTGTCACTCCTTTGAAGGGTGGCAGAGAGCTGGAATTGGTGCTGGATGGGCTGTGG 
               
               
                   
                   
                 GGTGACAGGGTCATGTGGAAAGCCCCTGGGGGGCACCTGGAAAAGGAGAAGCTGA 
               
               
                   
                   
                 CAGTACAGTGAGAGGACAGCTAAGGGAAAGCGGAATGGCAGAACACGCACTGCCA 
               
               
                   
                   
                 GGAGGAATGAGGATAGGGTCAGGAGTGCCAGGGGCAGTGAGGCCAGCCTGGGGT 
               
               
                   
                   
                 CAGGTGGCAGGACGTGTCCAGGAAGCTGGTCTGCACTGCAGCCCACACTGGCTCA 
               
               
                   
                   
                 GCCTTGAGGTTCCCTGTGTGGTTGGGGTAGGAAGTTGAACCCTCTGGGAATGGAAG 
               
               
                   
                   
                 ATGGAACCAGCTCTGCGAGCCAAGCTCAGCTTTTATCTATGGGTCTCTGAGGGCTG 
               
               
                   
                   
                 GCAGAGCTGAGTGGGGACAACTGTGATCCGTGAGGCTCTCAGGTTGAGGTGGCCC 
               
               
                   
                   
                 CTCCGGGAGGGCTTCATTTTCCCAGCGGGTAGGTTCTAAGCAGCAGTGGCTGGGCA 
               
               
                   
                   
                 GGTGGGTCCAACACAGAGCCAGAGAAGGGTGAATGGGCCTCCTGGCACCCCACCC 
               
               
                   
                   
                 CTGCTGCCCCTGAGCTCAGTGATGGAGGGGGACAGCACAGCTGAGCCCAAGTGCT 
               
               
                   
                   
                 TTGGTGTGGCCCTGAGGGAAAGCTGCAGCCTGCCTGGGGCCTGGCATGGATGGGA 
               
               
                   
                   
                 CACTTGAGGCAGAGGGACAATAGTGGGCGCTGCAGTGAGGCTGGCTCTTGGAGAG 
               
               
                   
                   
                 GTTTCCTGAGGAGTGCTGCCTGAGACGGGCAGGGAGAACAGAGACAAAGTTGGTGA 
               
               
                   
                   
                 CAGGGAATGAAAGCTGACTGAAGGACTTTACCCAGACCTATGAGGATATCTCTCTCA 
               
               
                   
                   
                 GCAGGAAGCAGGAGGGGACTGTGTGAGGACTGGCCAAGAGCTGGAGTGTTGGGAA 
               
               
                   
                   
                 AATGACTCTTTCTCCGACCCCTCTGTCCTAGCTCTGGCCCCTGGACTGCGGAGGTCT 
               
               
                   
                   
                 GCTTCCACCCCCATTGGTCGATCGTTGTCCCTTGTCACAGCCATTGAGAATTTTGGC 
               
               
                   
                   
                 AGGGAGCATGTTCTTAGAGCATTTTTAGGCTCTGCGGGACATAACAGCTCTGCCTCA 
               
               
                   
                   
                 GAGCACATGCCTTTCTCAGCTCCTGAAAGCCACTGATCAAATTGGAACATTTTGTAC 
               
               
                   
                   
                 CTTAGGGATGAGGATATCAACTCTCCCAGCCACTTAGAGGGATAAATGTGATGATGC 
               
               
                   
                   
                 ATTCAATTGTGACTACATCTGATCCCAACTGTTGCTTCAGCTGCTCTCCTATAGCACA 
               
               
                   
                   
                 TGGCGGGAGGCGTGCATCCCAGTAGCTACCTCCCCACTTTTGGGGAGATGTGGTTC 
               
               
                   
                   
                 CATCCATGAAACCTGGGTACCCGCCTACCAGGTCCTGGCCTATCAGGTGGCAGGGT 
               
               
                   
                   
                 CTGGTCAAAGAAGGGCATGTGTGGTCTTCAGCAAGGGAGACAGGACGGTGGTGCA 
               
               
                   
                   
                 GAGCGTCTAGACCCTCAGGGCAAGTCTCCCCCACACCTGCTCCCGGGGCAGTTGTC 
               
               
                   
                   
                 TTTGTGACCTCCCATCCCCCTCTGTTTCATCCTCTATAAAATGAGGGGCTGAGCCCC 
               
               
                   
                   
                 AAAATAACAGGCTTCTTTGCCATGATGCAAAACTGCTGAATCTTTCTTTCTGACACAC 
               
               
                   
                   
                 AAGGCATCGAGCAGCCTCTGAAAGAACCAAAGCCACTAGCAGGCTTCCTGACTTGG 
               
               
                   
                   
                 GTTTGTAGGTACTGAATACTCCCTTGAAAAATAAAAACATAGAGGCACTTTTCTCCTG 
               
               
                   
                   
                 GCTGTTTATTACAGAACGAAGAAAAAACACACTGGCTTGAAACAGACGCCAGATTTC 
               
               
                   
                   
                 AAATGTAGAGGTGAAATACGAGGTGGCAATTAAAATGTGATTACAGAAAGTCTGGAC 
               
               
                   
                   
                 ACTGAGAAAAGTTTACAGGACAGTGGGTGTGGGTTTTCTATAACAGACACTTAAATAT 
               
               
                   
                   
                 ACATGACGATAATTGCAGATAGAAACCATCAAAGACAAACCCCAAATCAACTAATAAT 
               
               
                   
                   
                 GTTTACAGATGTTCCCCCCCAAACCACAGAGCCTTACATCAAAACAAATACTGAAAG 
               
               
                   
                   
                 GCTTTAAACCAGGAACAGCTCGCCTTAACCCCACGAGGGTGCACACAAGCTGGGCT 
               
               
                   
                   
                 TTTTCTCTCGGTCTGAATGGTAAAGGGAGGAGGATACTCTAGCTCCTCCAGGTGGAT 
               
               
                   
                   
                 TGCTGAGACAGGGCTCGGCTCACACACTGTCTCTGCGCCTCTCCCAAATCTGGAGA 
               
               
                   
                   
                 ACTCTCCCAGCCTCCTGGTAAAGTGTCTCTGTGGGGCACTTAACGATAAAACAGCTT 
               
               
                   
                   
                 CTGCTGTAAAGCTCATTAGGAAAGAGCTAGCGGAGACTGAAAGGTTCGCAAAAGAG 
               
               
                   
                   
                 ATTAAGAATCACACAAGGCAATAGGATTTTTAGTGAACATAGAAATAAATGGCCAAGT 
               
               
                   
                   
                 GGTTTTCTATTTGGCATTTGTCAACTTGCACAACAACTCTTGGTCATATCCACATTGC 
               
               
                   
                   
                 TCATTGCATTAAAACCATAAGCGACTCAGCCACCTAGCTTAACAAGGTATCACTGGA 
               
               
                   
                   
                 GCAAACAACACGGTCTGCATATTTGTAACATTGTATAATAAACACAAAACAATGCATA 
               
               
                   
                   
                 GTAAACACAACTCTACTGAAACAAAAGCCGTCGCTTTATTTACAAAGTCACAAAATGA 
               
               
                   
                   
                 AGTATAAATACTTCTGTCATTAATGTTTAGGAAAACCATTTACAAAATTTTCAAATATG 
               
               
                   
                   
                 TACACGTAGCTTGAAAAATCACCAGCTTTCCATTTTGTCACAGGTAGAGAGAGGGAT 
               
               
                   
                   
                 AAGCATGGGCTGACAACACCACTCAAATTGTAACGGGAGACAACTGCGGGTATGGA 
               
               
                   
                   
                 TCGACACCACTTCCTAGAGTGATGTCACCATGGGGGTTTCTATGGGCATCCTGCTCA 
               
               
                   
                   
                 GATTTAAAGTGCCCCAGCATCCTGGGTGACTTGCCCAGAATTCTGGGCTGTGGCATT 
               
               
                   
                   
                 TTGAGCAGCAGCATGCTGTTCCAAAATGTCGTCGATCAGCCTCAAGTTGCACACCCA 
               
               
                   
                   
                 GTCTTCATCTGGGCTCACACAGGAGCCTTTCAAGAGAGCTTCAATGAAATCTACCTC 
               
               
                   
                   
                 ATTGCAGTCAGGTGACGAAATCAGATCATTTAGTGGGGGTTGGGGCTGGCGCAAAA 
               
               
                   
                   
                 AGTCGGCAGGTGGCAGCTCAGGGGGAATATCCGTTCTGTCGAACGGACCTGGGAA 
               
               
                   
                   
                 CTGGCTGGCAGCAACGGCAGAAGCAGCAGCAGCGGTGGCAGCAGCAGCCACATAG 
               
               
                   
                   
                 CTTGGTGGCTCGATGCCCTGTATGGGGCTCAGGGGACTAAAGCTGGCCATACCCTG 
               
               
                   
                   
                 CTGGAGGAACTTGGTGGTGTTTGCTACAGGCACCGGGCCCTGTACCGGGCTCTGCC 
               
               
                   
                   
                 TGAGGCTCTGGCTGCCCAGCAGGCTGAAGCTGGGGTTGTTGGCCAGGGGCACTTG 
               
               
                   
                   
                 TGTTCCCATCGCAGCGGGCACTTGTGCCTCCCAATCAGATGGCCTCTGAAGGCAGG 
               
               
                   
                   
                 CCTGGCCAGAAGGTGAGTGCTGCTGAACGCTATTATCCACTTGGCTGAGGGGTGTT 
               
               
                   
                   
                 TTCCCCGAAACTGCTGTGGTCACAGCTGCTGCCGCTGTGACCCATGCAGCATTGTT 
               
               
                   
                   
                 GAACGCAGTGGGCATTCTTGGCACACTAGGCCGTCTGAGCTGGTGGGGACTCAAG 
               
               
                   
                   
                 GACTGGGTGCCCAGGGAGCTGGGACAGAACCCAGGCAGGGGCACTTCTGGTGGG 
               
               
                   
                   
                 GTGGCCTTGGGGCTCTGCATATGCTGGCAGACAGAGTCAAGTCTGCCCAGGGGAGT 
               
               
                   
                   
                 CTGGCCTGAGTGTGAGAGGATGGGACACTGGGGGCTGGAGGTGAAAATTCCTTGC 
               
               
                   
                   
                 CGCTTCCCCAGAGTTGGTGAGATCACTCCCATGCCCTCGCAGCTCTGGTGCCTGGT 
               
               
                   
                   
                 GAGTGGGATCATTCCTGGACTCAGATTGTTCTGAAGAAGCCCAGTTCTGGGTGGCAT 
               
               
                   
                   
                 CAAGTGCTTGCTAGATGGGGGGCTTGCCTTGATCCGGCTACACTTGGAGGTGACTT 
               
               
                   
                   
                 GTTCTTGGACGGCTACATACAGAAAGAGAGAAGTGGGGATGAGTTCCAAAGGCATC 
               
               
                   
                   
                 CTCGACTTCGGCTGTGGCCACCGGAGGGTAGCTCCTGGCCCAACACGGACTTCTCA 
               
               
                   
                   
                 CCTCCCGCCCTTGGCTCTCTACTGAGCTCCCCCCTGCTCCCCAATTCCTCGCCATTC 
               
               
                   
                   
                 CCCTCATTTCTCTGCCCTCAGCCTGGACTGCAGTTCTTCTGGGAAGCTGCCCCAACT 
               
               
                   
                   
                 CCCTAGGTCTGTGCTCACCAAGAGCAGATCACACTGGACTGAAATGCCAGCTGATTT 
               
               
                   
                   
                 GTCTCTTCAAGAAAATTGGAAGCTCCTGGAGGTCAGGGTCCATGTCTGCTTTTACAC 
               
               
                   
                   
                 TCAGTGCTCTGTATGCAGGCCTGGCACTGCCCACCCTTTGACAGGTGGTGCATATTT 
               
               
                   
                   
                 TGTAGAAGGAAGGAAGGGGCCAGGTGGGGTGGGCTGGGCTGGTGGCGGGAGCTA 
               
               
                   
                   
                 GCTCAGCCTCTTAGATTCTCTACCCGATGGATGTGACCTGGGACAGCAAGTGAGTGT 
               
               
                   
                   
                 GGTGAGTGAGTGCAGACGGTGCTTTGTTCCCCTCTTGTCTCATAGCCTAGATGGCCT 
               
               
                   
                   
                 CTGAGCCCAGATCTGGGGCTCAGACAACATTTGTTCAACTGAACGGTAATGGGTTTC 
               
               
                   
                   
                 CTTTCTGAAGGCTGAAATCTGGGAGCTGACATTCTGGACTCCCTGAGTTCTGAAGAG 
               
               
                   
                   
                 CCTGGGGATGGAGAGACACGGAGCAGAAGATGGAAGGTAGAGTCCCAGGTGCCTA 
               
               
                   
                   
                 AGATGGGGAATACATCTCCCCTCATTGTCATGAGAGTCCACTCTAGCTGATATCTAC 
               
               
                   
                   
                 TGTGGCCAATATCTACCGGTACTTTTTTGGGGTGGACACTGAGTCATGCAGCAGTCT 
               
               
                   
                   
                 TATGGTTTACCCAAGGTCAGGTAGGGGAGACAGTGCAGTCAGAGCACAAGCCCAGT 
               
               
                   
                   
                 GTGTCTGACCCACCCAAGAATCCATGCTCGTATCTACAAAAATGATTTTTTCTCTTGT 
               
               
                   
                   
                 AATGGTGCCTAGGTTCTTTTATTATCATGGCATGTGTATGTTTTTCAACTAGGTTACAA 
               
               
                   
                   
                 TCTGGCCTTATAAGGTTAACCTCCTGGAGGCCACCAGCCTTCCTGAAACTTGTCTGT 
               
               
                   
                   
                 GCTGTCCCTGCAACTGGAGTGTGCCTGATGTGGCACTCCAGCCTGGACAAGTGGGA 
               
               
                   
                   
                 CACAGACTCCGCTGTTATCAGGCCCAAAGATGTCTTCCATAAGACCAGAAGAGCAAT 
               
               
                   
                   
                 GGTGTAGAGGTGTCATGGGCTACAATAAAGATGCTGACCTCCTGTCTGAGGGCAAG 
               
               
                   
                   
                 CAGCCTCTTCTGGCCCTCAGACAAATGCTGAGTGTTCCCAAGACTACCCTCGGCCT 
               
               
                   
                   
                 GGTCCAATCTCATCCCACTGGTGCGTAAGGGTTGCTGAACTCATGACTTCTTGGCTA 
               
               
                   
                   
                 GCCTGCAACCTCCACGGAGTGGGAACTACATCAGGCATTTTGCTAACTGCTGTATCC 
               
               
                   
                   
                 TAGGCCAATAAATGTTGATCACATTTATAGCTGCCATGGTAGGGTGGGGACCCCTGC 
               
               
                   
                   
                 TATCTATCTGTGGAGGCTCTGGGAGCCCCTGACACAAACTTTCTGAAGCAGAGCCTC 
               
               
                   
                   
                 CCCAACCCCTTTTCCATTCCCTATACCTGACAGATGGCCCAGGAACCCATTAGAAAT 
               
               
                   
                   
                 GGAAGGTCACTGCAGCAGTATGTGAATGTGCGTGTGGGAGAAGGGCAGGATCAGA 
               
               
                   
                   
                 GCCCTGGGGGTGTGGCAGCCCCCAAGTGATTCTAATCCAGATCCTAGGGTTGTTTC 
               
               
                   
                   
                 CCTGTCCCATTGAAATAGCTGCTTTAAGGGGCCTGACTCAGGGAAATCAGTCTCTTG 
               
               
                   
                   
                 AATTAAGTGGTGATTTTGGAGTCATTTAGACCAGGCCTTCAATTGGGATCCACTAGTT 
               
               
                   
                   
                 CTAGAGCGGCCGGGCCCAGGGAACCCCGCAGGCGGGGGCGGCCAGTTTCCCGGG 
               
               
                   
                   
                 TTCGGCTTTACGTCACGCGAGGGCGGCAGGGAGGACGGAATGGCGGGGTTTGGGG 
               
               
                   
                   
                 TGGGTCCCTCCTCGGGGGAGCCCTGGGAAAAGAGGACTGCGTGTGGGAAGAGAAG 
               
               
                   
                   
                 GTGGAAATGGCGTTTTGGTTGACATGTGCCGCCTGCGAGCGTGCTGCGGGGAGGG 
               
               
                   
                   
                 GCCGAGGGCAGATTCGGGAATGATGGCGCGGGGTGGGGGCGTGGGGGCTTTCTC 
               
               
                   
                   
                 GGGAGAGGCCCTTCCCTGGAAGTTTGGGGTGCGATGGTGAGGTTCTCGGGGCACC 
               
               
                   
                   
                 TCTGGAGGGGCCTCGGCACGGAAAGCGACCACCTGGGAGGGCGTGTGGGGACCA 
               
               
                   
                   
                 GGTTTTGCCTTTAGTTTTGCACACACTGTAGTTCATCTTTATGGAGATGCTCATGGCC 
               
               
                   
                   
                 TCATTGAAGCCCCACTACAGCTCTGGTAGCGGTAACCATGCGTATTTGACACACGAA 
               
               
                   
                   
                 GGAACTAGGGAAAAGGCATTAGGTCATTTCAAGCCGAAATTCACATGTGCTAGAATC 
               
               
                   
                   
                 CAGATTCCATGCTGACCGATGCCCCAGGATATAGAAAATGAGAATCTGGTCCTTACC 
               
               
                   
                   
                 TTCAAGAACATTCTTAACCGTAATCAGCCTCTGGTATCTTAGCTCCACCCTCACTGGT 
               
               
                   
                   
                 TTTTTCTTGTTTGTTGAACCGGCCAAGCTGCTGGCCTCCCTCCTCAACCGTTCTGAT 
               
               
                   
                   
                 CATGCTTGCTAAAATAGTCAAAACCCCGGCCAGTTAAATATGCTTTAGCCTGCTTTAT 
               
               
                   
                   
                 TATGATTATTTTTGTTGTTTTGGCAATGACCTGGTTACCTGTTGTTTCTCCCACTAAAA 
               
               
                   
                   
                 CTTTTTAAGGGCAGGAATCACCGCCGTAACTCTAGCACTTAGCACAGTACTTGGCTT 
               
               
                   
                   
                 GTAAGAGGTCCTCGATGATGGTTTGTTGAATGAATACATTAAATAATTAACCACTTGA 
               
               
                   
                   
                 ACCCTAAGAAAGAAGCGATTCTATTTCATATTAGGCATTGTAATGACTTAAGGTAAAG 
               
               
                   
                   
                 AGCAGTGCTATTAACGGAGTCTAACTGGGAATCCAGCTTGTTTGGGCTATTTACTAG 
               
               
                   
                   
                 TTGTGTGGCTGTGGGCAACTTACTTCACCTCTCTGGGCTTAAGTCATTTTATGTATAT 
               
               
                   
                   
                 CTGAGGTGCTGGCTACCTCTTGGAGTTATTGAGAGGATTATAAGACAGTCTATGTGA 
               
               
                   
                   
                 ATCAGCAACCCTTGCATGGCCCCTGGCGGGGAACAGTAATAATAGCCATCATCATGT 
               
               
                   
                   
                 TTACTTACATAGTCCTAATTAGTCTTCAAAACAGCCCTGTAGCAATGGTATGATTATTA 
               
               
                   
                   
                 CCATTTTACAGATGAGGAACCTTTGAAGCCTCAGAGAGGCTAACAGACATACCCTAG 
               
               
                   
                   
                 GTCATACAGTTATTAAGAGAAGGAGCTCTGTCTCGAACCTAGCTCTCTCTCTCTCGA 
               
               
                   
                   
                 GTAATACCAGTTAAAAAATAGGCTACAAATAGGTACTCAAAAAAATGGTAGTGGCTGT 
               
               
                   
                   
                 TGTTTTTATTCAGTTGCTGAGGAAAAAATGTTGATTTTTCATCTCTAAACATCAACTTA 
               
               
                   
                   
                 CTTAATTCTGCCAATTTCTTTTTTTTGAGACAGGGTCTCACTCTGTCACCTAGGATGG 
               
               
                   
                   
                 AGTGCAGTGGCACAATCACTGCTCACTGCAGCCTCGACTTCCCGGGCTCGGGTGAT 
               
               
                   
                   
                 TCTCCCCAGGCTCAGGGGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGGACTACA 
               
               
                   
                   
                 GGTGCGCACCACCATCCCTGGCTAATATTTGTACTTTATTTTATTTATTTATTTATTTA 
               
               
                   
                   
                 TTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCGGGCTGGAGTACAGTGGCATGATCT 
               
               
                   
                   
                 CGGCTCAGTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTACCTCATCCCCCT 
               
               
                   
                   
                 GAGTAGCTGGGATTACAGGCGCCTGCCACCATGCCTGGCTAATTTTTTGTATTTTTA 
               
               
                   
                   
                 ATAGAGACGAGGTTTCACCATGTTGGCCAGGCTACTCTCGAACTCCTGATCTCAGGT 
               
               
                   
                   
                 GATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGC 
               
               
                   
                   
                 CCGGCCTAATATTTGTATTTTTTGTAGAGATGGTGTTTTGCCATGTTGTCCAGGCTGG 
               
               
                   
                   
                 TCTTGAACTCCTGAGCTCAAGCGATCTGCCCGCCTCTGCTTCCCAAAGTGCTGGGAT 
               
               
                   
                   
                 TACAGGCATGAGCCACCGTGCCTGGCCTAGGTAGACGCTTTTAGCTTTGGGGTGTG 
               
               
                   
                   
                 ATGCCTGCCCCAGTATATAGTGAATTTAATTATTGCTAGAGCTGGCTGTTTGTTAGTT 
               
               
                   
                   
                 TTCTTTGAACATAAGATACTCATTGTTTTTAGTTTGCAAATCCCTCTTCCTTTTTAAAAA 
               
               
                   
                   
                 ATTTCTTTCCCTTAAATTGTTTGCATGTTAGCAATAACAAATGCTTAAATGGTGCTATG 
               
               
                   
                   
                 TGCTAGATACTCTTCTAAGCCCTGTTATGTATATTAACTAATTTTTTAAATTACACAAAT 
               
               
                   
                   
                 CAGAGAGGTTAAGTAACTTGCCCAAGATTACCCAACAATACTAGGATTTGAACCTAA 
               
               
                   
                   
                 GTTTGTCTCACCCCAGATTCTGCTCTTAATCTCTAAACTTTTAAGTTAGTAGTGACAAT 
               
               
                   
                   
                 AGTAGGTATTTATTGAATACTTAACTATGTTTTAGGCGTTGAAGTAAATATTTTGCAGG 
               
               
                   
                   
                 CATTATCTAATGTAAACACCCTAAAGTTACATAACAGGTACCCTTTAGGTAAATAAAC 
               
               
                   
                   
                 ACTAGTATGACCTTGGAGGCACAGATAGTTGAAGTAACTTGCCCAATATCACTTACAT 
               
               
                   
                   
                 GAAATTGGCCCTCAAATGTGTCTGATACAACCCATGCTGCTTGTAACTATCGTTTTAA 
               
               
                   
                   
                 ACTGCCAGGGTAAACTTGGACACACTTGAGCTAAGAAAAAGCTTTTAGATTTTTGCAA 
               
               
                   
                   
                 ATTAATGTGAAAGATATGCTTTATGTGGATATAATATCTTCTAAATTTCGGGGATGGTA 
               
               
                   
                   
                 GTCCTAGAAATGTAATCCTGCCCTAGCCGAGCTTACCCTGCCAATAATTTTTTACAGA 
               
               
                   
                   
                 ATTGGTAAAACGGAGCACCTTTTTTTTGTCCTTGGCCACACTGTTATCAACAGGGTGT 
               
               
                   
                   
                 AGATTGACATCAATCTGTAGGTGTAAACCAGAATTACTCTTTGTGACCACCAGGAAAT 
               
               
                   
                   
                 AGAGCAGTTCAGTTCAGGGGTTTCTTTCTGTGAATTTAGCACTGTGACCTGCATACTA 
               
               
                   
                   
                 CAAGTCTACTTTGTTTTCTATCCATTGTTTGTATCTGGGTATTGCAAAAGGTAGGAAA 
               
               
                   
                   
                 AGGACCAACCAGATCAGCAGAGAAGAGTTGCCTTGGAGTTTTCTTTTAGTTTTCTGC 
               
               
                   
                   
                 AGTTCATTAGATAGTAACTAGGCCATGTCATTTTACTCCCTTGTAGTGAAGATATGTT 
               
               
                   
                   
                 GAAGTTGTACTGGTATACTCTTCTACCTTTCTGTAATTTTATATTGTGTAGACTTGATA 
               
               
                   
                   
                 AAATTTATGTGTCAATCACCACCATTAATATCAATATTGAGCCTCAATTCTTATTTTTCT 
               
               
                   
                   
                 GCCCAGTGGCTGCCAAATTACTAACATTTACAATAATTCACTACTACTAAGATAATCT 
               
               
                   
                   
                 ACTAGTTCGATCACATACTTCAAATTGTTATGGAACTACTGTCTTCAGCATTGTGCTT 
               
               
                   
                   
                 CTGATAACTGATAAGTATAATTTTTTTTTTGTCCAGAGTGAACATGTCTATTCTTCCAC 
               
               
                   
                   
                 TGTACACACTAATAAAAGGAAAAATTGTAATATTGGGTAAATTCATGTCCTTACACAT 
               
               
                   
                   
                 GTAGTAGTTATGAGCCCATGTCCCTAGAATGAGTAATAATTTATCCCTCCCTTGGTTG 
               
               
                   
                   
                 AATAGTCAAGAATGCTGATTTTAATTCTTCTAACAGCTTTATCCCTCAGAAGGGAAGG 
               
               
                   
                   
                 CAAGCAAGTTATATATGTAGTTTATTTGTAAGACTGATATGAAATTGGAAGATGAATCT 
               
               
                   
                   
                 ACTATTAGCTTTAATTATTTTTACATTTAGGAATATTGCATCAGTAACTCATAATTTTGG 
               
               
                   
                   
                 TTTTCTGTTATCCTGAGTTAACACAAATTATCCAAGGAGATGGCGGATCATCTGCTTT 
               
               
                   
                   
                 GAGGTGTTTTTTTTTGAGAATTTTAATGTATCTGAATATAAAAGGTAAAAATATGCCAA 
               
               
                   
                   
                 CTAGCAATTTCTGCCCATTCCAGAAGTTTGGAAATATTACTCATTACTAGGAATTAAAT 
               
               
                   
                   
                 AAAATATGGTTTATCTATTGTTATACCTCTTTTAATTCACATAGCTCATTTTTATCTTTT 
               
               
                   
                   
                 ATTTTTGTTTGTTTTTTTTGAGATGGAGTCTTGCTCTGTCACCAGGCAGGAGTGCAGT 
               
               
                   
                   
                 GATGCAAATCTCGGCTCACTCTAGCCACCGACTCCCTGGTTCAAGCGATTCTCCTGC 
               
               
                   
                   
                 CTGAGCCTTCTGAGTAGCTGGGATTACAGGCAGGCACCACCACGCCCAGCTAATTT 
               
               
                   
                   
                 TTGTAGAGACAGGATTTCACCGTGTTGGCCAGGATGGTCTCCATCTCCTGACCTCAT 
               
               
                   
                   
                 GATCTGCCTGCTTCGGCCTCCCAAAGTGCTGGGATTACAGGTGGGAGCCACTACGC 
               
               
                   
                   
                 CTGGCCCACATAGCTCATTTTTAGACTCACTTCCATTAAGTCTTGTTTGGACCCACGA 
               
               
                   
                   
                 ACATTGTCTTTTTTTTTTTAAGATGGAGTTTCACTTTTGTTGCCCAGACTGTAGTGCAA 
               
               
                   
                   
                 TGGTGCAATCTCAGCTCACTGCAATCTCTGCCTCCTGGGTTCTAGCAATTCTCCTGC 
               
               
                   
                   
                 CTCAGCCTCCCGAGTAGCTGGAATTACAGGCGCCCGCCACCACGCCCAGCTAATTT 
               
               
                   
                   
                 TTGTGTTTTTAGTAGAGACGGGGTTTCACCATGTTGGGCAGGCCAGGGGTGATCCG 
               
               
                   
                   
                 CCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCATCTGGCC 
               
               
                   
                   
                 AACATGTCTTTTTTTTTTTTTTCCTTTTTAACCACAAAGAGACTTAAGCAGTCCTTGTC 
               
               
                   
                   
                 ACAGATGATGAATTGATGTTGCAAGTATTGTCTTAGCTTGGATTAATTTTCTTGCTTAC 
               
               
                   
                   
                 TGTAATTTTAGATAATATAGCTTTGTAATTAGAGATTTTATGTGTAAACCACAAAAATG 
               
               
                   
                   
                 TTTACATGAAGGCCATTATTACAGATGTGACGTGCATAATTATTAGTAATTTGTATGTT 
               
               
                   
                   
                 TACATGGGTCAGTCTGGCAAAAAATTATGAAGTTTTAAAAATTAAAAAAAATTATAATG 
               
               
                   
                   
                 CCAGTTTTACTGGAAAGTAAAATTATTTCAGTAATCGATTATAGCAAAAGTATTGATTT 
               
               
                   
                   
                 TCATTCCAGACAAAAGTCAGAATGAAAGGTAATTTCTCAATACTCTTTCAGATTAATAA 
               
               
                   
                   
                 AAGTACCTGTAGCGATTTTTATCATTCACAAGTATATCACAAGTAAGTTAGAATTTGA 
               
               
                   
                   
                 GAACTGTGTTCTAGATCTCTGAGGAGATGCAGTCAGATTTCTGAACTGTCTCAGCAA 
               
               
                   
                   
                 ATGGTAAGTAACTTAGAGCTAGTAATTAATAACCTGTCCTTTGATTTCTGATTCAGCC 
               
               
                   
                   
                 AAGAATGGCCATATTTGGGAAAGGCAGATCTGGAGAGTAACCACGTTTTCATTCATT 
               
               
                   
                   
                 TACCACTTCTAGGCCCCTCCAGAGCTCTCAGATATTTTGGGGTTGAGCCCTTCCCCA 
               
               
                   
                   
                 AAGCCATACAGGACCTTTTTTTTGTGATCTGTTCTAGCCATTTTTATGTTGGGTGCTT 
               
               
                   
                   
                 GTTATGGACTGAGCATTTATGTCCTCCCACACCCCCCCCATACCTTTTTTGAAGTCCT 
               
               
                   
                   
                 AACCCCCAGTGTGATGGTATTTGGAGACAGGGCCTTTGGAAGGTAATTACAGTTAGA 
               
               
                   
                   
                 AGAAGTCGGGAGGGTTGGGCCCAGGTCTGATTGGATTAGTGCCCTTATATGAAAAG 
               
               
                   
                   
                 ACACCAGGACGGGCGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAA 
               
               
                   
                   
                 GGTGGGTGGATCACGAGGTCAGGAGTTTGAGACCAGCCTGGCCAATGTAGTGAAAC 
               
               
                   
                   
                 ACCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTAGCGGGCTCCTGTCATC 
               
               
                   
                   
                 CAAGCTACTCGGGAGGGTGAGGCATGAGAATCACTTGAACCCGGGAGTTGGAGGTT 
               
               
                   
                   
                 GCAGTGAGCCCAGATTGTGCCACTGTACTCCAGCCTGGGTGACAGAGTGAGACTCT 
               
               
                   
                   
                 GTCTCAAAAAAGAAAAAAAAAAAAAAAGAGACACCAGAGAGCTTGTTAGAAGAGGTC 
               
               
                   
                   
                 ATGTGAGCACACAGTTAGAAGACCTTCAAGCCAAAGAAGAGGCCTGAGATTGAAACC 
               
               
                   
                   
                 TACCTTGCAGGTACCTTAATTTTGGACTTCCCAGCCTCCAAAACTGTGAGAAATAAGT 
               
               
                   
                   
                 TTCTGTTAAGTCACTCAGTCTGTGGTATTTTGTTATGGCAGCCTGAGCAGGTAGTTGT 
               
               
                   
                   
                 TCTTTCAGAAGGTGTTGATAATAACCACATGCAACACCAAGTCACAAATAATAAAACA 
               
               
                   
                   
                 GATGTAACTTATATTCATACAGAAAGTTGGGCACTGCCATTGCCTTGTTGGTTTACAC 
               
               
                   
                   
                 GGCTGTGCTAGTTCAGTAGCAGAAAGGTGCTGGTCTCCTTTACTCAGTTTACAATCT 
               
               
                   
                   
                 AGGCAGTAGAATGTAATCACTGCTTTAAACTTGATACTGCTTAGGGAGAGAATCATTG 
               
               
                   
                   
                 GTGCTGGGTAACTTTGGGTTCTAGGTTTACTTTTTGTGTATATATAACTGTTTTTGGTA 
               
               
                   
                   
                 AATCACAAGTTTCTGGGCTTGTCGAATTAGATTTTGTTACAGATTATGAGCTTTATTAT 
               
               
                   
                   
                 GCTATACAGTTAGTTGTATGTATATATGCCTTTCCCACTAGATTTTAAGCTTTTTTTTTT 
               
               
                   
                   
                 TTTTTTTTTTTGTGACGGAGTCTTGCTCTTGTCGCCCAGGCTGAAGTGGAGTGCAGT 
               
               
                   
                   
                 GGCACAATCTCGGCTCACTGCAGCCTCCACCTCCTAGGTTCAAGCGATTCTCCTGC 
               
               
                   
                   
                 CTCGGCCTCCCAAGTAACTGGGACTACAGGCACGTGCCACCACACCCGGCTAATTT 
               
               
                   
                   
                 TTGTATTTTTTGTAGAGACAGGGTTTCGCCATGTTGGCTAGGCTGGTCTTGAACTTCT 
               
               
                   
                   
                 GGCCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTTACAGGCATG 
               
               
                   
                   
                 AGCCACCACGCCCAGCTATAGCTCTTTAAGGGTTGTAAATTTATAATCATTCTTTTAC 
               
               
                   
                   
                 TCTCCTGCAAATTCTGTTGCACACTGCCTTAATCAAGGTAGATGCTGAATGCATTTTT 
               
               
                   
                   
                 GTATAATTGAATATGTTGCAATCCCCAACTCTCTCCAACTGTTCCTGTCAAAGCAGCC 
               
               
                   
                   
                 ACTGGATTGTTAACTAATCCATATTAGATGGGGTTAATTAATATCAGATGGGACAAGT 
               
               
                   
                   
                 AAGGGCTAATAAGATTATAGGCCACCAAGTAGATTTCTGTCTAGCTCTTATAGAGATT 
               
               
                   
                   
                 GAGTTTATTGGACCTGTTTGATAGGAAGTTTTGGTGTTTGGGATGATTAAAACTGAAG 
               
               
                   
                   
                 TTCCTATTTATTGAATTATACCTATTTATATTATTTCATATCAGTGGTCCACATGCAAGT 
               
               
                   
                   
                 GAGGCTTCTGAGACAGAGTTTGAGTTCTCTCTTCAACTACCATAACACTTAACCTGTA 
               
               
                   
                   
                 TCTTTTTTTTTTTTTTTTTTTTTAGACAGGAGTCTCGCTCTGTCACTCAGGCTGGAGTG 
               
               
                   
                   
                 TAGTGGTATGATCTCGGCTCACTGTAACCTCTGCCTCCTGGATTCAAGCAGTTCTCC 
               
               
                   
                   
                 ATGTCTCAGCCTCCCTAGTAGCTGGGATTACAGGCCTGTGCCACCATGCCTGGCTA 
               
               
                   
                   
                 ATTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTTACCACGTTGGCCAGGCTGGTCT 
               
               
                   
                   
                 CGAACTCTTGACCTCGAGCGATCAACTTGCCTTGGCCTCCCAAAGTGCTGGGATTAC 
               
               
                   
                   
                 AGGCATGAGCCACAGCGCCCAGCCGTCTTTTTTTTTAAATAGCAATTTAACACTGTTC 
               
               
                   
                   
                 ACAGTTACTCATGTACATGTCATGCCATCTATTACACTGTAAGTTCTGTGAGGGTAGC 
               
               
                   
                   
                 TGTATCAAATTTATCTAACTCTCTCTAGTATGCATGACATAGTAAGTATTCAATAAATA 
               
               
                   
                   
                 TTTGCATATTAGTGATAAGGATACAGGTTCTGAATAGTGGGTCCTTACCATTTAAGAA 
               
               
                   
                   
                 TTAGTATTTGATGGCCGGGCGGGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA 
               
               
                   
                   
                 GGCTGAGGCGGGCGGATCATGAGATCAGGAGATCGAGACCATCCTGGCTAACATG 
               
               
                   
                   
                 GTGAAATCCCGTCTTTACAAAAAAAATACAAAAGAATTAACCAAGTGTGGTGGTGGG 
               
               
                   
                   
                 TGCCTGTAGTCCCAGCTACTGCTTTGTGAGGCTGAGGCAGGCAGATCACCTGAGGT 
               
               
                   
                   
                 GGGAAATTCAAGACCAGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATAC 
               
               
                   
                   
                 AAAATTAGCCGGGCGTGGTGGCGCATGTCTGTAATCCCAGCTACTCGGGAGGCTGA 
               
               
                   
                   
                 GGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAGGATCGC 
               
               
                   
                   
                 GCCACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAA 
               
               
                   
                   
                 AAAAAAAAATTAGTATTTGATATTTGATCATTAAATATGAATTAAGAGGACTTAGACTT 
               
               
                   
                   
                 TTTGTTAAATGTCAAGCTGGGAAAAGTTGTCATTTAAATGAATTGCCTCTTATTTAATT 
               
               
                   
                   
                 TCGTCTGATGATACATTTTGTTTTTATTTTGTAAAAAATTATTTTTTTTCTTTTTGGAGA 
               
               
                   
                   
                 CAGGGTCTTGCTCTGTTGCCCAGGCTGGTCACAAACTCCTGACCTCAAGCAATCCTC 
               
               
                   
                   
                 CTGCCTTAGCCTCCCAAAATGCTGGGATTACAGGCGTGACGACCTCGCCCGGCCTT 
               
               
                   
                   
                 GTATTATGATACATTTTGAACAACTACAAGTAGACTTGGTATAATGAACCTGCACGTA 
               
               
                   
                   
                 CCCATTGCCAAGTTCTGACAACTGTCTGTCTATAGCCAATTATGCATTTCTTAAATTA 
               
               
                   
                   
                 GAACCCCCCCAATATACCCAAATATATATATATGTGTGCATATATATAGTAAGTTGTAA 
               
               
                   
                   
                 CAAAGTTGTGAATTCATACCTGAAGTATCTCAAGTGATGCAAGTTTTATGAATTTTTGT 
               
               
                   
                   
                 TTATGCCTTTTGGGAAGAGTTGTATTGACAAATTTTTTATGCTTAAAGTAAACCATAAA 
               
               
                   
                   
                 TCAAAAAAATAAAATCTAGGATGCAATAAAACAAAACAACTTCTTGACATAAGTATGG 
               
               
                   
                   
                 TATGTAAATCTGTTTTGATTGGAAATCAATTTGTTATATTGCCAGAATTCCTGTTTTAG 
               
               
                   
                   
                 AATACATCTCTGCTGATCTGTCTGTATTCTTAGACTGCATATCTGGGATGAACTCTGG 
               
               
                   
                   
                 GCAGAATTCACATGGGCTTCCTTTGAAATAAACAAGACTTTTCAAATTCTTAGTCGAT 
               
               
                   
                   
                 CTGCAGAACCTGTAGCCAGGCACTGAACCATTTTGATAGATGCAGTAATCGTTGCAA 
               
               
                   
                   
                 GTGTATATTTCAAGGGAGTTCTGGCTGGGTCCTAGTTTATGCTTGTGGCAGAAGCAG 
               
               
                   
                   
                 TGAGTAACTGGGAGGAAGTTGGTGAGTAAGCTTCAAGGAAGAAGTCATTTTTAGTAC 
               
               
                   
                   
                 TCTGGATCTTCCTGATTTTAAAGCACTACAAAATGGTGCATTTTCATTCTTGTCAAGT 
               
               
                   
                   
                 GATAACAGATATATTCTGATGAGCCTGAAATGAATATATATTGTATCATTTTTATAATA 
               
               
                   
                   
                 TCTAGCAAGGTTTGTATTTTCCTAGAACTTGAACTAAATTTCAGTTCATAAAATTTATA 
               
               
                   
                   
                 AAATACTTAGTTGTTGTAAAATATTTTTGGAATGTTCACATAGGTGACACACAAATGTC 
               
               
                   
                   
                 CCATTTTCATTCTTTCTATAGTAAATATGTTCTGATATGTGAAGGTTTAGCAGATGCAT 
               
               
                   
                   
                 CAGCATTTAATCCTAGAGGATCTGGCATAATCTTTTCCCCCAAGAATAGAAATTTTTT 
               
               
                   
                   
                 CTGCTTATGAAAGTAGTACATGTTTCTTTAAAAACAAATCAATATTGACTTCTGCCTGC 
               
               
                   
                   
                 TGTATAGCACTATGCCTCCACCTGGCCATGACCAGGGGCATGTCCTGGTCCACCTA 
               
               
                   
                   
                 CCTGAAAATGTTTGCAACCAGCCTCCTGGCCATGTGCACAGGGGCTGAAGTTGTCC 
               
               
                   
                   
                 CACAGGTATTACGGGCCAACCTGACAATACATGAAGTTCCACCAAAGTCTGAGAACT 
               
               
                   
                   
                 CAGAACTGAGCTTTGGGGACTGAAAGACAGCACAAACCTCAAATTTCTCAGCACTGG 
               
               
                   
                   
                 AAACCTCAAAATATAACTGAATTCCATAAATAAGATTTTAAGTCTTAAATATGTATTTTT 
               
               
                   
                   
                 AAATGTATTAAAAGTCAAGCTGCTTGTATTTAAGCACCTAATACAATGCTTAGGTTGT 
               
               
                   
                   
                 AAAAGGAGATGCTCAATAGGTACTAACTGATATATTGAGATTTAATTATGGTTTGACC 
               
               
                   
                   
                 AATATTTATTGGAAACCGCCAAAGCTTAAATCATCAGCTTCTTGAATGTGATTTGAAA 
               
               
                   
                   
                 GGTAATTTAGTATTGAATAGCATGTGAGCTAGAGTATTTCATTCTTTCTGGTTTATTTC 
               
               
                   
                   
                 TTCAAATAGACTTTGAATATAATGGTGAATGGGTATTATAAATTAACTAATAAAAATGA 
               
               
                   
                   
                 CATTGAAAATGAAAAAATATATATATTAAAGTGTAGAAAGTGACCAGGCGTGGTGGCT 
               
               
                   
                   
                 CACACCTGTAATCCAAGCACCTTGGGAGGCTGAGGCAGGAGGATCTCTTGATCCCA 
               
               
                   
                   
                 GGAGTTCAAGACCAGCCTGGGCAACATAGCGAGACTTCGTCTCTAAAAAAAAAAAAG 
               
               
                   
                   
                 AGAGAGAAAAAAATTTTTTTTATTTAAAAAAAGTGTAGAAAGTGTCAAGACCCCACTT 
               
               
                   
                   
                 CTTACCATTATTTGGTATATTTCTCTATACCCACCCACCCTTCCTCCTTACTCCCTCCC 
               
               
                   
                   
                 TCCCTTCCCAATCTTTTTATCTTTTTGTATTCTGATTTTTTGTTTGTATATTTTGCTTTAA 
               
               
                   
                   
                 TTTAATGTATCCTTTAAAAATTTCCCATACATTTTATATGTATATATAAAAACGCATGCT 
               
               
                   
                   
                 GCCAAAGATAATTTATAAGAAAGACCATTGAATTTTTTTAAAAGTGATATATATTCATT 
               
               
                   
                   
                 GAAAAAAATTTAGAATATATAGCAAAGCAATAAAGAACTAAATAAAATTGCTGTAACTC 
               
               
                   
                   
                 CTCTTTCAAAGATAAGTGCTTTTATGATTTTGTTGTATTTTTTTCTGTATATAGGTACAT 
               
               
                   
                   
                 ATATAGTATTTATAAAGCTGTACTCATAGTACATTTTCACATCACAGGTACCATATCAG 
               
               
                   
                   
                 TGTTATTAAATATTTTGTATGCCAGGGGCTAGACATACCAAGACAACCAATATGTGGT 
               
               
                   
                   
                 TCTACTTAAATAATATTAGAGTATCTTTTATGATGACACTTCATGAGTTGACTATAATA 
               
               
                   
                   
                 ATCTTAGACTTCTAAGAGTTTGGGTTTTCAAAAGATCACTTAGCTTTTTTGGGTGATTT 
               
               
                   
                   
                 TTCCCCCTTACTGTGAGATGAGAGAGGCTGTTTGGATTTGGGATTGGGGTAGCGGG 
               
               
                   
                   
                 GACAGCAACTTTTCTTTTCTTTTTCTTTTTTATTTTGAGGTAGGGTATTGCTGTGTCAC 
               
               
                   
                   
                 CCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCCACCTCCCGGGC 
               
               
                   
                   
                 TCAGGTGATCCTCCTGCTTCAGCCTCCCAGTAACTGGGACTACAGGCGCGTGCCAC 
               
               
                   
                   
                 ATGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCT 
               
               
                   
                   
                 GGTCTCTAACTCCTGACCTCAGGTGATACGCCCACCTGGGCCTCCCAAAATACTGG 
               
               
                   
                   
                 GATTACAGGCATGAGCCGCTGCATCAGCCAGCAGTTTTTCTTGTGGTTTTTTTTGTTT 
               
               
                   
                   
                 GTTTTGTTTTGTTTTGTTTTTGAGATAGGGTCTTACTCTGTTGTCCACGCTGGAGTGC 
               
               
                   
                   
                 TGTGGTATGATCGTAGCTCACTGCAGCCTCAAACTCCTGGGCTCAAGTGATTCCTTC 
               
               
                   
                   
                 TGCCTCCGCCTCCCGAGTAGCTGGGACTACAGGTATGCACCACCATACCTGGCAAA 
               
               
                   
                   
                 TTTTTACAAAGTTTTTTGTAGGGACGGGGTCTTGCTACATTCCCCATGTCGGTCTTGA 
               
               
                   
                   
                 ACTCCTGGCCTCAAGCAACTCTCCTGTCTCAGCCTCCCAAAGCACTGGGATTACAAG 
               
               
                   
                   
                 TGTGAGCCACCACACCATGCCAGTTTTTCCTGTTCAGTGTGATATTTTATCTTGTTAG 
               
               
                   
                   
                 ACTACAGTGTGTTAAAACTTGTTTTACTAAATTTTCAAACATACTCAAAAGTGGAGAGA 
               
               
                   
                   
                 ATAGTATAATGAATACCCGTATGTTCATCACCCATGTTTAGAATATTATTAAATATAAA 
               
               
                   
                   
                 GATTTTGCTGCGTTTGTCTTAGCTCTTTAAAATTTTTCTTTTTCTCTTTGTGACCTAAA 
               
               
                   
                   
                 GGAAATTCCATATCTTATCACTTTACTTCTACATTCTTGACTAAGATGACTAAGACATA 
               
               
                   
                   
                 TAGTTACATGGTTTTTTGTTTTGTTTTTGTTTTTTAAAGACGAAATCTCGCTCTTGTCC 
               
               
                   
                   
                 CCCAGGCTGGAGTGCAATGGTGCCATCTCAGCTCAGTGCAACCTCTGCCTTCTGGG 
               
               
                   
                   
                 TACAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCTCCTGCCA 
               
               
                   
                   
                 CCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGCGGGGGGAGGTTTCACCAT 
               
               
                   
                   
                 GTTGACAAGGCTGGTCTGGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTC 
               
               
                   
                   
                 CCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCTGTTTTTTTGTTTGT 
               
               
                   
                   
                 GTGTTTTGTTTTTTTTGAGACAGAGTCTTGCTCTGTTTCCCAGGCTGGAGTGAAGTG 
               
               
                   
                   
                 GTGCCATCTCAGCTCAGAGACAGAGTCTTGCTCTGTTTCCCAGGCTGGAGTGAAGT 
               
               
                   
                   
                 GGTGCCATCTTGGCTCACTGCAACCTTCACCTCCCAGGTTCAAGTGATTCTCCTGCC 
               
               
                   
                   
                 TCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGTCACCACACCCGGCTAATTTTT 
               
               
                   
                   
                 TTGTATTTTTAGTAGAGACGGGATTTCACCGTGTTGCCCAGGCTGGTCTCGAACTCC 
               
               
                   
                   
                 TGAGCTCAGGCAGTCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGTGTG 
               
               
                   
                   
                 AACCAACCCGCCCGGCCTGTTGTTTTCTTACATAATTCATTATCATACCTACAAAGTT 
               
               
                   
                   
                 AACAGTTACTAATATCATCTTACACCTAAATTTCTCTGATAGACTAAGGTTATTTTTTA 
               
               
                   
                   
                 ACATCTTAATCCAATCAAATGTTTGTATCCTGTAATGCTCTCATTGAAACAGCTATATT 
               
               
                   
                   
                 TCTTTTTCAGATTAGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTA 
               
               
                   
                   
                 ATCATTATGCTGAGGATTTGGAAAGGGTGTTTATTCCTCATGGACTAATTATGGACAG 
               
               
                   
                   
                 GTAAGTAAGATCTTAAAATGAGGTTTTTTACTTTTTCTTGTGTTAATTTCAAACATCAG 
               
               
                   
                   
                 CAGCTGTTCTGAGTACTTGCTATTTGAACATAAACTAGGCCAACTTATTAAATAACTG 
               
               
                   
                   
                 ATGCTTTCTAAAATCTTCTTTATTAAAAATAAAAGAGGAGGGCCTTACTAATTACTTAG 
               
               
                   
                   
                 TATCAGTTGTGGTATAGTGGGACTCTGTAGGGACCAGAACAAAGTAAACATTGAAGG 
               
               
                   
                   
                 GAGATGGAAGAAGGAACTCTAGCCAGAGTCTTGCATTTCTCAGTCCTAAACAGGGTA 
               
               
                   
                   
                 ATGGACTGGGGCTGAATCACATGAAGGCAAGGTCAGATTTTTATTATTATGCACATCT 
               
               
                   
                   
                 AGCTTGAAAATTTTCTGTTAAGTCAATTACAGTGAAAAACCTTACCTGGTATTGAATG 
               
               
                   
                   
                 CTTGCATTGTATGTCTGGCTATTCTGTGTTTTTATTTTAAAATTATAATATCAAAATATT 
               
               
                   
                   
                 TGTGTTATAAAATATTCTAACTATGGAGGCCATAAACAAGAAGACTAAAGTTCTCTCC 
               
               
                   
                   
                 TTTCAGCCTTCTGTACACATTTCTTCTCAAGCACTGGCCTATGCATGTATACTATATG 
               
               
                   
                   
                 CAAAAGTACATATATACATTTATATTTTAACGTATGAGTATAGTTTTAAATGTTATTGGA 
               
               
                   
                   
                 CACTTTTAATATTAGTGTGTCTAGAGCTATCTAATATATTTTAAAGGTTGCATAGCATT 
               
               
                   
                   
                 CTGTCTTATGGAGATACCATAACTGATTTAACCAGTCCACTATTGATAGACACTATTTT 
               
               
                   
                   
                 GTTCTTACCGACTGTACTAGAAGAAACATTCTTTTACATGTTTGGTACTTGTTCAGCTT 
               
               
                   
                   
                 TATTCAAGTGGAATTTCTGGGTCAAGGGGAAAGAGTTTATTGAATATTTTGGTATTGC 
               
               
                   
                   
                 CAAATTTTCCTCTAAGAAGTTGAATCATTTTATACTCCTGATGTTATATGAGAGTACCT 
               
               
                   
                   
                 TTCTCTTCACAATTTGTCTCTTTTTTTTTTTTTTTTGAGACAAGGTCTCTGTTGCCCAG 
               
               
                   
                   
                 GCTGGGGTGCAGTGCAGCAGAATGATCACAGTTCACTGCAGTCTCAACCTCCTGGG 
               
               
                   
                   
                 TTCAAGCGATCCTTCCACCTCAGCCTCCTGAGTAGCTGGGACTATAGGTGTGCGCC 
               
               
                   
                   
                 ACCACTCCCAGCTAATATTTTTATTTTGTAGAAACAGGGTTCGCCATGTTACCCAGCC 
               
               
                   
                   
                 TCCCAAAGTGCTGGGATTACAGGCATGAGCCACTGGCCCAGTTTCTACAGTCTCTCT 
               
               
                   
                   
                 TAATATTGTATATTATCCAGAAAATTTCATTTAATCAGAACCTGCCAGTCTGATAGGTG 
               
               
                   
                   
                 AAAATGGTATCTTGTTTTTATTTGCATTTAAAAAAAATTATGATAGTGGTATGCTTGGT 
               
               
                   
                   
                 TTTTTTGAAGGTATCAAATTTTTTACCTTATGAAACATGAGGGCAAAGGATGTGATAC 
               
               
                   
                   
                 GTGGAAGATTTAAAAAAAATTTTTAATGCATTTTTTTGAGACAAGGTCTTGCTCTATTG 
               
               
                   
                   
                 TCCAGGCTGGAGTGCAGTGGCACAATCACAGTTCACTCCAGCCTCAACATCCTGCA 
               
               
                   
                   
                 CTAAAGTGATTTTCCCACCTCACCTCTCAAGTAGCTGGGACTACAGGTACATGCTAC 
               
               
                   
                   
                 CATGCCTGGCTAATTTTTTTTTTTTTGCAGGCATGGGGTCTCACTATATTGCCCAGGT 
               
               
                   
                   
                 TGGTGTGGAAGTTTAATGACTAAGAGGTGTTTGTTATAAAGTTTAATGTATGAAACTT 
               
               
                   
                   
                 TCTATTAAATTCCTGATTTTATTTCTGTAGGACTGAACGTCTTGCTCGAGATGTGATG 
               
               
                   
                   
                 AAGGAGATGGGAGGCCATCACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAA 
               
               
                   
                   
                 ATTCTTTGCTGACCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCC 
               
               
                   
                   
                 ATTCCTATGACTGTAGATTTTATCAGACTGAAGAGCTATTGTGTGAGTATATTTAATAT 
               
               
                   
                   
                 ATGATTCTTTTTAGTGGCAACAGTAGGTTTTCTTATATTTTCTTTGAATCTCTGCAAAC 
               
               
                   
                   
                 CATACTTGCTTTCATTTCACTTGGTTACAGTGAGATTTTTCTAACATATTCACTAGTAC 
               
               
                   
                   
                 TTTACATCAAAGCCAATACTGTTTTTTTAAAACTAGTCACCTTGGAGGATATATACTTA 
               
               
                   
                   
                 TTTTACAGGTGTGTGTGGTTTTTTAAATAAACTCCTTTTAGGAATTGCTGTTGGGACTT 
               
               
                   
                   
                 GGGATACTTTTTTCACTATACATACTGGTGACAGATACCCTCTCTTGAGCTACATCGG 
               
               
                   
                   
                 TTTGTGGGGAGTCAAAAGTCCTTTGGAGCTAGGTTTGACAAATAAGGTGGGTTAACA 
               
               
                   
                   
                 CTTGTTTCCTAGAAAGCACATGGAGAGCTAGAGTATTGGCGAATTGAAGAAATCCCC 
               
               
                   
                   
                 CTTTTTTTTTAACACACTTAAGAAAGGGGACTGCAGGTATACTCAAGAGAGTAAGTCG 
               
               
                   
                   
                 CACCAGAAACCACTTTTGATCCACAGTCTGCCTGTGTCACACAATTGAAATGCATCA 
               
               
                   
                   
                 CAACATTGACACTGTGGATGAAACAAAATCAGTGTGAATTTTAGTAGTGAATTTCATT 
               
               
                   
                   
                 CATAATTTGATCGTGCAAACGTTTGATTTTTATTACTTTAGACTATTGTTTCTGATTTTA 
               
               
                   
                   
                 TGTTGGGTTGGTATTTCCTGTGAGTTACTGTTTTACCTTTAAAATAGGAATTTTTCATA 
               
               
                   
                   
                 CTCTTCAAAGATTAGAACAAATGTCCAGTTTTTGCTGTTTCATGAATGAGTCCTGTCC 
               
               
                   
                   
                 ATCTTTGTAGAAACTCGCCTTATGTTCACATTTTTATTGAGAATAAGACCACTTATCTA 
               
               
                   
                   
                 CATTTAACTATCAACCTCATCCTCTCCATTAATCATCTATTTTAGTGACCCAAGTTTTT 
               
               
                   
                   
                 GACCTTTTCCATGTTTACATCAATCCTGTAGGTGATTGGGCAGCCATTTAAGTATTAT 
               
               
                   
                   
                 TATAGACATTTTCACTATCCCATTAAAACCCTTTATGCCCATACATCATAACACTACTT 
               
               
                   
                   
                 CCTACCCATAAGCTCCTTTTAACTTGTTAAAGTCTTGCTTGAATTAAAGACTTGTTTAC 
               
               
                   
                   
                 GGTATCGATAAGCTTGATATCAAAACGCCAACTTTGACCCGGAACGCGGAAAACACC 
               
               
                   
                   
                 TGAGAAAAACACCTGGGCGAGTCTCCACGTAAACGGTCAAAGTCCCCGCGGCCCTA 
               
               
                   
                   
                 GACAAATATTACGCGCTATGAGTAACACAAAATTATTCAGATTTCACTTCCTCTTATTC 
               
               
                   
                   
                 AGTTTTCCCGCGAAAATGGCCAAATCTTACTCGGTTACGCCCAAATTTACTACAACAT 
               
               
                   
                   
                 CCGCCTAAAACCGCGCGAAAATTGTCACTTCCTGTGTACACCGGCGCACACCAAAAA 
               
               
                   
                   
                 CGTCACTTTTGCCACATCCGTCGCTTACATGTGTTCCGCCACACTTGCAACATCACA 
               
               
                   
                   
                 CTTCCGCCACACTACTACGTCACCCGCCCCGTTCCCACGCCCCGCGCCACGTCACA 
               
               
                   
                   
                 AACTCCACCCCCTCATTATCATATTGGCTTCAATCCAAAATAAGGTATATTATTGATGA 
               
               
                   
                   
                 TGTTT 
               
               
                   
               
               
                 124 
                 HDAd2xBITEs 
                 AAACATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGGGGGT 
               
               
                   
                   
                 GGAGTTTGTGACGTGGCGCGGGGCGTGGGAACGGGGCGGGTGACGTAGGTTTTAG 
               
               
                   
                   
                 GGCGGAGTAACTTGTATGTGTTGGGAATTGTAGTTTTCTTAAAATGGGAAGTGACGT 
               
               
                   
                   
                 AACGTGGGAAAACGGAAGTGACGATTTGAGGAAGTTGTGGGTTTTTTGGCTTTCGTT 
               
               
                   
                   
                 TCTGGGCGTAGGTTCGCGTGCGGTTTTCTGGGTGTTTTTTGTGGACTTTAACCGTTA 
               
               
                   
                   
                 CGTCATTTTTTAGTCCTATATATACTCGCTCTGCACTTGGCCCTTTTTTACACTGTGAC 
               
               
                   
                   
                 TGATTGAGCTGGTGCCGTGTCGAGTGGTGTTTTTTTAATAGGTTTTCTTTTTTACTGG 
               
               
                   
                   
                 TAGGCGCGCCGTCGACGCGACAACTGTCTTATTACCCTGTTATCCCTACCTTAATTA 
               
               
                   
                   
                 AGCTAGCCGACGCGTTGGCCAGGAGCTCAGATCTCCGGATCCAAGCTTATCGATTT 
               
               
                   
                   
                 CGAACCCAAATGGATCTACCACATTTGTAGAGGTTTTACTTGCTTTAAAAAACCTCCC 
               
               
                   
                   
                 ACACCTCCCCCTGAACCTGAAACATAAAATGAATGCAATTGTTGTTGTTAACTTGTTT 
               
               
                   
                   
                 ATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAG 
               
               
                   
                   
                 CAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTT 
               
               
                   
                   
                 TGTCCAAACTCATCAATGTATCTTATCATGTCGAGCTAGCTAGTCAGGACTTCAGTTC 
               
               
                   
                   
                 CAGCTTTGTGCCGGCTCCGAAGGTCAGCGGGTTGCTAGACCATTGCTGACAGTAAT 
               
               
                   
                   
                 ATGTGGCGGCATCCTCGGCTTCCATAGAGCTGATTGTCAGGCTGTAGCTGGTGCCA 
               
               
                   
                   
                 GATCCAGATCCGCTGAATCTGTAGGGCACGCCGGAGGCCACTTTGCTTGTGTCGTA 
               
               
                   
                   
                 GATCCACCGCTTGGGGCTTGTGCCAGACTTCTGCTGATACCAGTTCATGTAGGACAC 
               
               
                   
                   
                 GCTGCTGCTGGCTCTGCATGTCATGGTCACTTTCTCGCCTGGGGAAGCGCTCATGA 
               
               
                   
                   
                 TGGCGGGGCTTTGTGTCAGCTGAATATCGGAGCCACCACCACCGCTTCCACCACCA 
               
               
                   
                   
                 CCTGAACCGCCTCCGCCACTAGAAACTGTCAGGGTTGTGCCCTGGCCCCAGTAATC 
               
               
                   
                   
                 CAGACAGTAGTGGTCGTCGTAGTACCGGGCACAATAGTACACAGCGCTATCTTCAG 
               
               
                   
                   
                 AGGTCAGGCTGGACAGCTGCATGTAGGCGGTAGAGCTGCTCTTGTCGGTGGTCAGT 
               
               
                   
                   
                 GTGGCCTTGTCCTTGAACTTCTGGTTGTAATTGGTGTAGCCCCGGCTGGGGTTGATG 
               
               
                   
                   
                 TAGCCGATCCATTCCAGTCCTTGGCCAGGCCTCTGCTTGACCCAGTGCATGGTGTA 
               
               
                   
                   
                 CCGGGTGAATGTGTAGCCGCTGGTCTTGCAGGACATCTTCACAGAGGCGCCAGGTC 
               
               
                   
                   
                 TAGCCAGTTCGGCGCCAGACTGTTGCAGCTTGATATCGGATCCACCGCCACCAAGG 
               
               
                   
                   
                 GCTTTGATTTCCAGCTTGGTGCCGCTGCCGAAGGTGAAAGGGGTTCTGAAGTGCTG 
               
               
                   
                   
                 CTGACAAAAGTACACGGCCAGATCCTCGGCCTGCACGCTGCTGATGGTAAAGGTGA 
               
               
                   
                   
                 AGTCAGGGCCAGAGCCAGAGCCGGTGAATCTAGAGGGCACGCCTGTGTATCTGCT 
               
               
                   
                   
                 GCTGGCGCTGTAGATCAGCAGCTTAGGAGACTGGCCAGGCTTCTGCTGATACCAGG 
               
               
                   
                   
                 CCACGGCGTTGTACACGTCCTGGCTGGCTTTACAGGTGATGGACACTCTGTCGCCC 
               
               
                   
                   
                 ACGCTGGTGCTCAGAAACTTGTGGCTCTGGGTCAGCTGAATATCAGATCCTCCGCC 
               
               
                   
                   
                 GCCTGAACCTCCGCCTCCGCTTCCTCCGCCACCAGAAGAGACTGTCACGGTTGTGC 
               
               
                   
                   
                 CCTGGCCCCAATATGGCACGTAGCCGTGGTACACTTCCCATCTGGCACAAAAGTAG 
               
               
                   
                   
                 GTGGCCATGTCCTCGGACTTCAGGTTGTTGATCTGCAGGTAGGCGGTGTTGGCGCT 
               
               
                   
                   
                 GGTTTCCAGGCTGAAGTCGAATCTGCCCTTGAAATCGTCGGCGAAGGTGCTCTCGC 
               
               
                   
                   
                 CGGTGCTGGTATTGATCCAGCCCATCCATTTCAGGCCCTGTCCAGGGGCCTGCTTG 
               
               
                   
                   
                 ACCCAGTTCATGCCGTAGTTGGTGAAGGGGTAGCCGCTGGCCTTGCAGGAGATCTT 
               
               
                   
                   
                 CACTGTCTCGCCAGGTTTCTTCAGCTCGGGGCCAGACTGCTGCAGCTGAACTTCAG 
               
               
                   
                   
                 AATGGGCGCCTGTGGCGGCTCCCACAAGAAACAGGATGCGCCAGATCCAGTCCATG 
               
               
                   
                   
                 GAAGGTCCGGGGTTCTCTTCCACGTCGCCACATGTCAGCAGGCTGCCTCTGCCTTC 
               
               
                   
                   
                 GGACTTCAGTTCCAGCTTTGTGCCGGCTCCGAAGGTCAGCGGGTTGCTAGACCATT 
               
               
                   
                   
                 GCTGACAGTAATATGTGGCGGCATCCTCGGCTTCCATGCTGGAGATTGTCAGGCTG 
               
               
                   
                   
                 TAGCTGGTTCCGCTGCCGCTTCCGGAAAATCTGTAGGGCACGCCGGAGGCCACTTT 
               
               
                   
                   
                 GCTTGTGTCGTAGATCCACCGCTTGGGGCTTGTGCCAGACTTCTGCTGATACCAGTT 
               
               
                   
                   
                 CATGTAGGACACGCTGGAGCTGGCTCTACAGGTCATGGTCACTTTCTCGCCTGGGC 
               
               
                   
                   
                 TAGCGCTCATGATGGCAGGAGACTGGGTCAGCTGAATATCAGAACCGCCACCACCG 
               
               
                   
                   
                 CTTCCGCCGCCACCTGAACCACCACCACCTGAAGAAACTGTCAGTGTGGTGCCCTG 
               
               
                   
                   
                 GCCCCAGTAATCCAGACAGTAGTGGTCGTCGTAGTACCGGGCACAATAGTACACAG 
               
               
                   
                   
                 CGCTATCTTCAGAGGTCAGGCTGCTCAGCTGCATGTAGGCGGTAGAGCTGCTCTTG 
               
               
                   
                   
                 TCGGTGGTCAGAGTGGCCTTGTCCTTGAACTTCTGGTTGTAATTGGTGTAGCCCCGG 
               
               
                   
                   
                 CTGGGGTTGATGTAGCCGATCCATTCCAGTCCTTGGCCAGGCCTCTGCTTGACCCA 
               
               
                   
                   
                 GTGCATGGTGTACCGGGTGAATGTGTATCCGCTGGTCTTGCAGCTCATCTTCACAGA 
               
               
                   
                   
                 AGCGCCAGGTCTAGCCAGCTCGGCGCCAGACTGTTGCAGCTTAATATCGCTGCCTC 
               
               
                   
                   
                 CGCCTCCGCCACTAGACACTGTGACCAGTGTTCCTCTGCCCCAGTAGTCGAGGCCC 
               
               
                   
                   
                 TGTCTGGCGCAATAATACACGGCGGTGTCCTCGGCTCTCAGGGAGTTCATCTGCAG 
               
               
                   
                   
                 GTACAGGCTGTTCTTGGCGTTGTCCCGGCTGATGGTGAATCTGCCCTTGATGCTGTC 
               
               
                   
                   
                 CAGGTAGTAGGTGTAGCTGCCGCCGCTGCTGATTGTGGACACCCATTCAAGGCCTT 
               
               
                   
                   
                 TGCCAGGAGCCTGTCGGACCCAGCTCATATCGTAGCTGCTGAAGGTGAAGCCGCTG 
               
               
                   
                   
                 GCGGCACAAGACAGTCTCAGAGATCCGCCAGGCTTAACCAGGCCTCCGCCTGATTC 
               
               
                   
                   
                 CACCAGCTGAACTTCAGATCCACCACCGCCGGATCCGCCGCCTCCGCTTCCTCCGC 
               
               
                   
                   
                 CGCCAGATCCTCCGCCACCTCTCTTGATTTCCACCTTGGTGCCTCCGCCAAATGTCA 
               
               
                   
                   
                 GGGGATTGCTGGACCACTGCAGGCAGTAGTACACGGCGAAGTCCTCAGGTTCCAG 
               
               
                   
                   
                 GCTGCTTATGGTCAGGGTGAAATCGGTGCCGCTGCCAGAGCCAGAAAATCTGGCAG 
               
               
                   
                   
                 GCACTCCGCTGGCCAGATTGCTGGTCAGGTAGATCAGGATTCTAGGGGCCTGTCCG 
               
               
                   
                   
                 GGCTTCTGCTGCAGCCAGTAGATGTAGTTGATGGAGCTGCTGGCGCTACAGCTCAG 
               
               
                   
                   
                 TGTGGCTCTTTCGCCAGGGCTAAGAGACAGTGTGGCAGGGCTCTGTGTCAGCACAA 
               
               
                   
                   
                 TCTCGCCGGTGGTATCAGGCAGCCACAGCAGCAGCAGAAACAGCAGTTGAGCTGGA 
               
               
                   
                   
                 GCCTCCATGGTGGCCCTCCTTCGCCGGTGATCTCAGCTGTAGGAAAGAGAAGAAGG 
               
               
                   
                   
                 TTAGTAGTCGACGTGTCCCTCTCGATGAATCTAAGTATCAATTGTGAGCGCTCACAA 
               
               
                   
                   
                 GTCAACACTCTTTTTGATAAATCTAGTAGATATCACTTACGTAGGCGCCGGTCACAGC 
               
               
                   
                   
                 TTGGATCTGTAACGGCGCAGAACAGAAAACGAAACAAAGACGTAGAGTTGAGCAAG 
               
               
                   
                   
                 CAGGGTCAGGCAAAGCGTGGAGAGCCGGCTGAGTCTAGGTAGGCTCCAAGGGAGC 
               
               
                   
                   
                 GCCGGACAAAGGCCCGGTCTCGACCTGAGCTTTAAACTTACCTAGACGGCGGACGC 
               
               
                   
                   
                 AGTTCAGGAGGCACCACAGGCGGGAGGCGGCAGAACGCGACTCAACCGGCGTGGA 
               
               
                   
                   
                 TGGCGGCCTCAGGTAGGGCGGCGGGCGCGTGAAGGAGAGATGCGAGCCCCTCGA 
               
               
                   
                   
                 AGCTTCAGCTGTGTTCTGGCGGCAAACCCGTTGCGAAAAAGAACGTTCACGGCGAC 
               
               
                   
                   
                 TACTGCACTTATATACGGTTCTCCCCCACCCTCGGGAAAAAGGCGGAGCCAGTACA 
               
               
                   
                   
                 CGACATCACTTTCCCAGTTTACCCCGCGCCACCTTCTCTAGGCACCGGTTCAATTGC 
               
               
                   
                   
                 CGACCCCTCCCCCCAACTTCTCGGGGACTGTGGGCGATGTGCGCTCTGCCCACTGA 
               
               
                   
                   
                 CGGGCACCGGAGCGATCGCAGATCCTTCGATAGAGAAATGTTCTGGCACCTGCACT 
               
               
                   
                   
                 TGCACTGGGGACAGCCTATTTTGCTAGTTTGTTTTGTTTCGTTTTGTTTTGATGGAGA 
               
               
                   
                   
                 GCGTATGTTAGTTACGATTCACACAAAAAACCAACACACAGATGTAATGAAAATAAAG 
               
               
                   
                   
                 ATATTTTATTGCGGCCGCTCGAGTCTAGAGGTATACATGCCATGGTCCGCGGTATTA 
               
               
                   
                   
                 CCCTGTTATCCCTAAGACAACTGTCCTGCATGCGACGTCGGCGCGCCATCGAATTC 
               
               
                   
                   
                 CTGCAGCCCGGGGGATCCCTTTGTTGATTTTTTCCACATAGATTATTTTTGACTGTTT 
               
               
                   
                   
                 TGGCACTTTATATAAATGGAATCATATAGTAAATATATACATGTATATATGTATATATA 
               
               
                   
                   
                 CACTATATATGTATATATATAGTGTATATATATACATGTATATATGTATATTTACATATA 
               
               
                   
                   
                 TACTGTATATATGTATATTTACATATATACTGTATATATGTATATATACACGTATATACT 
               
               
                   
                   
                 GTATATATACAGTATATACTGTATATATATACTGTATATATGTGTATATATATATACAGT 
               
               
                   
                   
                 ATATATACAGTATACATATATATACATGTATATATACACAGTATATATACATGTATATAT 
               
               
                   
                   
                 ACACAGTATATATACATGTATATATACACAGTATATATACATGTATATATACACAGTAT 
               
               
                   
                   
                 ATATACACTGTATATATGTATATATATACTGTGTATATATATACAGTATATATACAGTAT 
               
               
                   
                   
                 ATATATACATGTATATGTATATATATACTGTATATATGTGTATATATACGTATATATACT 
               
               
                   
                   
                 GTATATATATATAGACACTTTTGTGTCTGGCTTCTTGCTCTCATCATAAAGCACTTGAA 
               
               
                   
                   
                 ATCCATCCATGTTGTAGCTGGTATCAGTAGCTAGTTTCTTTTCATTGCTGAGAAGTAT 
               
               
                   
                   
                 CACTTTTTATTGATGAGTAGTTTTACATTGTATGAACATGCCCGAGTTTGTTTATGCAT 
               
               
                   
                   
                 TCTACTAATAGACACCTGGGCTGTTTGCAGTTTTTGGCTATTACAAAGAAAATTTCTA 
               
               
                   
                   
                 TATTTTTTTCCAACTTTTATTTTAGGTTCAGCGGGTACATGGGCAGGTTTGTTACATC 
               
               
                   
                   
                 GGTAAATTGCATGTCACTGGGGTTTGGTGTACAGATTATTTCACCACCCAGGTAATA 
               
               
                   
                   
                 AGCATAGTACCTGATAGGCAGGTTTTTGATCCTCACCCTCCTCCCTCAAGTAGGCCC 
               
               
                   
                   
                 CAGTGTCTATTGTTCTATTCCTTTTTTTTTTTTTTGAGATGGAGTCTCACTCTGTTGCC 
               
               
                   
                   
                 CAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGGTCCACCTCCAGGGTT 
               
               
                   
                   
                 CAAGCGATTCTACTGCCGCAGCCTCCCGAGTAGCTGGGATTACAGGCACCCACCAC 
               
               
                   
                   
                 CACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACTGGGTTTCACCATGTTGGCCAG 
               
               
                   
                   
                 GATGGTCTCGAACTCCTCACCTCAGGTGATCCGCCCGCTTCGGCCTCGCAAAGTAC 
               
               
                   
                   
                 TGGGATTACAGGCGTGAGCCACGGTGCCTGGCCTATGGTTCCATTCTTTGTGTACAC 
               
               
                   
                   
                 GTGTACTCAGTGTTTAGCTTCCACTTGTAAGTGAAAACATGCAGTATTTGGTTTTCTG 
               
               
                   
                   
                 AAATTCTTGTCTTCATCTTTTTGTAGACAATCCACTACTTTTATTTTTAAATATTAGGAA 
               
               
                   
                   
                 CAATAGCCTCTGTGTGTCCTGAATTGCAATGTTTTTTCTCTGATTTTGCTGCTCATCTT 
               
               
                   
                   
                 GTAACCTGTATGGTGTTTTTCTGTGTGCAAGCTTTTTACTTTACGTGGGCAATTTTAT 
               
               
                   
                   
                 CATTCTTTTCTTTTATGGTTTCTGGGTTTCATGTCATGATTGGAGAAGCTTGATCTACC 
               
               
                   
                   
                 CTGATACTATAAAAATATCCACCTTGGCTTTTTTTTTTTTTTTTAGATGGATTTTCACTC 
               
               
                   
                   
                 TTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCACCACAACCTCTGCCT 
               
               
                   
                   
                 CCCAGGTTCAAGTGATTCTCCTGCCTCGGCCTCCTGAGTAGCTGGGATTACAGGCA 
               
               
                   
                   
                 TGCGCCACCACGCTCAGCTAATTTTGTATTTTTAGTAGAGACAGGATTTCACCATGTT 
               
               
                   
                   
                 GGTCAGGCTGGTCTTGAACTCCCCACCTCAGGTGATCTGTCTGCCTCGGCCTCCCA 
               
               
                   
                   
                 AAGTGCTGGGATTACAGGCGTGACCCACCACACCTGGCCCACGTTGTTTTCTGATA 
               
               
                   
                   
                 GTGTTTTCACGTGTTATTTTTTCTGTCTTACTCTTTGAATCATCTAAATGTATCTTAATG 
               
               
                   
                   
                 TCAGGAGTGAGGTAGAGGACCCAGTTGTTTGGTTTAAATGACTAGCCAGTTTTCCCA 
               
               
                   
                   
                 ACACCAGGTGTTGAACATCCCTCACTGATGTGAGATGCTGCCTTTTTCACAGTCTCA 
               
               
                   
                   
                 ATCCCCATGTGCATTTCTATTTATTTTCCTTCCACTTTATTCACATCTTTTTCAGTATCC 
               
               
                   
                   
                 ACAACCATATTGTTTTAAATAGCTTCATGATATGTTTTAATATTTGGTAGAGCTAGAAC 
               
               
                   
                   
                 CCTTTCTTGGTTCTTTTTCTTTTCTTCTTCTCCTCCTTTTCCTCCTCCTTCTTTCTCCTC 
               
               
                   
                   
                 CTCCTTCTTCTTTCTTTTTAGAAATTTCCTGGCTATTCTTGTTTTGTAGTCTTCCAGAT 
               
               
                   
                   
                 AAATAATTTTGAATCACTTTGTCATGTTCCAGAAAATAATACTGCCAGAATTTTTATTG 
               
               
                   
                   
                 TGATCACAGAAGTTTTACAGATTCATCTGGGGGAAAAAAACCCATCTTCCCAGAATAC 
               
               
                   
                   
                 AGAAAGGGTGAGGGAAAGACAAACATCAAGGACAAGTCTCAGGTTCTGGACTTGGA 
               
               
                   
                   
                 GACCAAGAGGATTTGGGGCATCCGGGAGCAGGGCAGGGAGGTGTGATGGCTGCCT 
               
               
                   
                   
                 TTCACTGAGTAGGAGGATGCCCAGACTTGGGGGAACTATGGAAAGTTTGGTTCAGA 
               
               
                   
                   
                 CTTTCTGAGTTGGAGATGTCTATGCGCAGTCCACAGGGCGAAGCCCTGGAGGTAGA 
               
               
                   
                   
                 GGCCCTCCTTACTGCCTCCCTCATTCAGTCTGAGGTCCATTCTCCACATGGACACTG 
               
               
                   
                   
                 AAGTGACTCAAGGCTTCCCTTGTTGGATCAGGATAGTCTCCAGGGCCCTGGGTGGT 
               
               
                   
                   
                 CTGGGCCTGCCCACCTCCCCATCCCCTCTCCTGCCTGCCCTCCTCTTGCTCACTGG 
               
               
                   
                   
                 ACCCCACCCACCAGCCTCCTTCTATTCCTCCTGACATTTGCACTTGCTGTTCCGTCT 
               
               
                   
                   
                 CTGCTTGGAACATCCTAGCTCTTTGCATGGCTTGCTCCTTCCCATCTTTTAATCTAAG 
               
               
                   
                   
                 CTCAAATATCACTCCTTCAGATATGCCTTTCCCAAATATCCTAGCTAAAGAGAACTGC 
               
               
                   
                   
                 TCCCCACTTCCCACAAGCCCTAGCAAACTGGGACTCTCCTTCTTGCTTTCTTTCTCTC 
               
               
                   
                   
                 TGCCCCTTCTGTGTTTTTTCCATAGACCTTAACTTGTTACTGTTTTATTTGTTGATGTG 
               
               
                   
                   
                 TTTACATCATTTGTCCCCCTGTGATGGTTAGTTTTATGTGTCAACTTGGCTAGGCTGT 
               
               
                   
                   
                 AGGGGCTGTTCGTCAATCAAACACTGATCTATGTGTAGCTGTGAAGGGATTTTGTAG 
               
               
                   
                   
                 CTGTGATTAATAGTTGACTTTAAGTAAGGAAGATTATCCTGGAGAATGTGGGGGAAG 
               
               
                   
                   
                 GGGCAGACCTCAGCCAATCAGTTGAAAGGCCTTAAGAACAAAGCTGAGATTTCCCC 
               
               
                   
                   
                 GAGGAAGAAGAAATTCTGCCTGTGGACTGCAGCATCAGCTCCTGCTTGAGAGGTTC 
               
               
                   
                   
                 CAGGCTGCCCTTCCTGACAGCCTGTCCTATGATTTTGGACTTGCCTTGCCAGGTTTT 
               
               
                   
                   
                 TCCTCTTTCTTGACCCCCCAAAACCATATATATCTCCTGCTGGTTTGTTTCTCTGGTG 
               
               
                   
                   
                 TAATCCTGAGGGATGAACACTCCTCCCTCCCAGTTCACTCTGGGAGAGGTTGGGGA 
               
               
                   
                   
                 TCATGTTTGTCTATTTCCCCATGCCTGGCCCATGCGTGTTTATTGAATCACTGAACAA 
               
               
                   
                   
                 CCACGCATTAGGAAGCCAGTCATATGTGCTTCTTCAGAACCTCATGTCCATTGCCAG 
               
               
                   
                   
                 ATCTCCCTGGCTTTTGTGGCTAGAGGACAAGTGAGAGATAGTAGCTTACCCACAGAC 
               
               
                   
                   
                 CTTGGCCCTGAGGCCCCCAGGGGCCTGAGCCTGCTGTAAGGGAGGAGGGAGCCCC 
               
               
                   
                   
                 TGAGGTCTCACACACCTCCCTGGGGATCTGGCATTTTCCCCTGGGGCTGGCCTCAG 
               
               
                   
                   
                 AGCTGGGCGGGGGCAGATTATGGAGTGGGTTGTAGAGGGAGCACCTCCCCACTAG 
               
               
                   
                   
                 CAATCATGGTTTTTTCTGCGCCTCTCATAGGGAGGCCTACAGGCCTCCACCTTCAGC 
               
               
                   
                   
                 TCTTCAGGAGCCACAGGCAGCTGAGTGACTTCTGCATCACAGTCTTCTCAGAGACAA 
               
               
                   
                   
                 ACTTGCAGTAAGAAAGAGGGGCCCGTGAGGGACCCCAGAGAAGGCTGTTGTCAAAG 
               
               
                   
                   
                 CAGGATGAGAGTGAACTCTTCCATGGGGGACACCCAGCGTCTCCAAGCTCTTTTATG 
               
               
                   
                   
                 CTGTCTTCAAGGGGTCTAGAGAGCTTCAGCCCAACATGAGACCCAGTCCAGCAGCA 
               
               
                   
                   
                 TTTCCCTGCGAAGTGAAAGTTAGGACCCTGACTAGATACACCACGCTGACCTCAGCC 
               
               
                   
                   
                 AGAATATCAAGATGCTGAGGCGCTGAGATGCTGGGATGCTAAGGTGCTAAGGTGCT 
               
               
                   
                   
                 GGGGTGCTGGGGTGCTAGGATGCTGAGGTTTTGTGATACTGGGTCGCTGAGATGCT 
               
               
                   
                   
                 GGGATACTGGGGTGCTGAAGTGCTGGGGTACTGGGGTGTTGCCATGCTGAAATGCT 
               
               
                   
                   
                 GGGGTGTTGGGATGCTGAGGTGCTGGGTTGCTGGGATGCTGGGATAGTCCTTGGAT 
               
               
                   
                   
                 GCTGCGGTGCTGAGATGCTGGTCTGCTGGTCTGCTGGGGTGTTGGGATGCTGGGA 
               
               
                   
                   
                 TTTTGGGATGCTGGAGTGCTGCAGTGCTGCAGTGCTGAGATGCTGGAGTGCTGGGG 
               
               
                   
                   
                 TGCTGGAATACTGTAGTACTGGTGTGCTGGAGCATTGAGATGCTAGGGCACTGGGA 
               
               
                   
                   
                 TGCTAAGGTGCTGAGATGCTGCAGTGCTGGGGTGTTGGGATGCCGAGGTGTTGGG 
               
               
                   
                   
                 ATGCTTAAGTGCTGGGGTGTTGGGATGCTGGGGTGCTGGAACACTATGGTGCTGGG 
               
               
                   
                   
                 GTGCTGGAGTGTTGAGATACTGTAGTGGTGGGATGCTTAAGTGCTGGGGTGCTGGG 
               
               
                   
                   
                 TGTTGGGATGCCTAGGTGCTGGGGTGCCGAGATGCTGGAGTACTAGTGTGCTGGGA 
               
               
                   
                   
                 TGCTGAAGTGCTGGGGTCCTGAGATGCTGCAGTGCTAGGGTGCTGAGATTCTGGGC 
               
               
                   
                   
                 TGCTGGAGTGTTGGGGTGCTGGGATGCTGGAGTGCTGAGATGCTTGGACAATGGG 
               
               
                   
                   
                 GTGCTGGAATACTATGGTGCTGGGGTGCTGGGGTATTGAGATGCTAGGGTACTGGG 
               
               
                   
                   
                 ATGCTGAAGTGCTGAGATCCTGGAGTGCTGGGCTGCTGGGCCACAGGCTCTTGAAT 
               
               
                   
                   
                 CCATTCGTCTGCCCAGGGGAAGAAACCAGAAGATAAAGAGCTAATGAAGGAGCTTT 
               
               
                   
                   
                 GGTTGAGAGGGAGGAAGTAATGGAAGGAGCAACATCTTGTGGAGGAGCAGGAGAG 
               
               
                   
                   
                 AATGGACCTCAGGTTGGGAGAGAGGGCCAGGCTACAGGCCAGAGAGGCAGAAGGA 
               
               
                   
                   
                 TTCCAGCAGAGTGTGGGCTCCAGGAGCCAAGGGGAAACAGGTTTCTGGGAGGAGA 
               
               
                   
                   
                 GAGTCCAGTACTGCTGAAGTGGCAAGTCCGCTGAGGACCAGGAAGCTTCATTTGGC 
               
               
                   
                   
                 TTTATGACCAGGAGGAATTTGGAACTGTGACTAGAGTACTTAGGGGGAAGGAGGCA 
               
               
                   
                   
                 AGACTGGAGCCAGATTGCTCTGGGTTGAGGGGTGAGTGGGAGGTGAAGCAGGGCA 
               
               
                   
                   
                 CTGTCACTCCTTTGAAGGGTGGCAGAGAGCTGGAATTGGTGCTGGATGGGCTGTGG 
               
               
                   
                   
                 GGTGACAGGGTCATGTGGAAAGCCCCTGGGGGGCACCTGGAAAAGGAGAAGCTGA 
               
               
                   
                   
                 CAGTACAGTGAGAGGACAGCTAAGGGAAAGCGGAATGGCAGAACACGCACTGCCA 
               
               
                   
                   
                 GGAGGAATGAGGATAGGGTCAGGAGTGCCAGGGGCAGTGAGGCCAGCCTGGGGT 
               
               
                   
                   
                 CAGGTGGCAGGACGTGTCCAGGAAGCTGGTCTGCACTGCAGCCCACACTGGCTCA 
               
               
                   
                   
                 GCCTTGAGGTTCCCTGTGTGGTTGGGGTAGGAAGTTGAACCCTCTGGGAATGGAAG 
               
               
                   
                   
                 ATGGAACCAGCTCTGCGAGCCAAGCTCAGCTTTTATCTATGGGTCTCTGAGGGCTG 
               
               
                   
                   
                 GCAGAGCTGAGTGGGGACAACTGTGATCCGTGAGGCTCTCAGGTTGAGGTGGCCC 
               
               
                   
                   
                 CTCCGGGAGGGCTTCATTTTCCCAGCGGGTAGGTTCTAAGCAGCAGTGGCTGGGCA 
               
               
                   
                   
                 GGTGGGTCCAACACAGAGCCAGAGAAGGGTGAATGGGCCTCCTGGCACCCCACCC 
               
               
                   
                   
                 CTGCTGCCCCTGAGCTCAGTGATGGAGGGGGACAGCACAGCTGAGCCCAAGTGCT 
               
               
                   
                   
                 TTGGTGTGGCCCTGAGGGAAAGCTGCAGCCTGCCTGGGGCCTGGCATGGATGGGA 
               
               
                   
                   
                 CACTTGAGGCAGAGGGACAATAGTGGGCGCTGCAGTGAGGCTGGCTCTTGGAGAG 
               
               
                   
                   
                 GTTTCCTGAGGAGTGCTGCCTGAGACGGGCAGGGAGAACAGAGACAAAGTTGGTGA 
               
               
                   
                   
                 CAGGGAATGAAAGCTGACTGAAGGACTTTACCCAGACCTATGAGGATATCTCTCTCA 
               
               
                   
                   
                 GCAGGAAGCAGGAGGGGACTGTGTGAGGACTGGCCAAGAGCTGGAGTGTTGGGAA 
               
               
                   
                   
                 AATGACTCTTTCTCCGACCCCTCTGTCCTAGCTCTGGCCCCTGGACTGCGGAGGTCT 
               
               
                   
                   
                 GCTTCCACCCCCATTGGTCGATCGTTGTCCCTTGTCACAGCCATTGAGAATTTTGGC 
               
               
                   
                   
                 AGGGAGCATGTTCTTAGAGCATTTTTAGGCTCTGCGGGACATAACAGCTCTGCCTCA 
               
               
                   
                   
                 GAGCACATGCCTTTCTCAGCTCCTGAAAGCCACTGATCAAATTGGAACATTTTGTAC 
               
               
                   
                   
                 CTTAGGGATGAGGATATCAACTCTCCCAGCCACTTAGAGGGATAAATGTGATGATGC 
               
               
                   
                   
                 ATTCAATTGTGACTACATCTGATCCCAACTGTTGCTTCAGCTGCTCTCCTATAGCACA 
               
               
                   
                   
                 TGGCGGGAGGCGTGCATCCCAGTAGCTACCTCCCCACTTTTGGGGAGATGTGGTTC 
               
               
                   
                   
                 CATCCATGAAACCTGGGTACCCGCCTACCAGGTCCTGGCCTATCAGGTGGCAGGGT 
               
               
                   
                   
                 CTGGTCAAAGAAGGGCATGTGTGGTCTTCAGCAAGGGAGACAGGACGGTGGTGCA 
               
               
                   
                   
                 GAGCGTCTAGACCCTCAGGGCAAGTCTCCCCCACACCTGCTCCCGGGGCAGTTGTC 
               
               
                   
                   
                 TTTGTGACCTCCCATCCCCCTCTGTTTCATCCTCTATAAAATGAGGGGCTGAGCCCC 
               
               
                   
                   
                 AAAATAACAGGCTTCTTTGCCATGATGCAAAACTGCTGAATCTTTCTTTCTGACACAC 
               
               
                   
                   
                 AAGGCATCGAGCAGCCTCTGAAAGAACCAAAGCCACTAGCAGGCTTCCTGACTTGG 
               
               
                   
                   
                 GTTTGTAGGTACTGAATACTCCCTTGAAAAATAAAAACATAGAGGCACTTTTCTCCTG 
               
               
                   
                   
                 GCTGTTTATTACAGAACGAAGAAAAAACACACTGGCTTGAAACAGACGCCAGATTTC 
               
               
                   
                   
                 AAATGTAGAGGTGAAATACGAGGTGGCAATTAAAATGTGATTACAGAAAGTCTGGAC 
               
               
                   
                   
                 ACTGAGAAAAGTTTACAGGACAGTGGGTGTGGGTTTTCTATAACAGACACTTAAATAT 
               
               
                   
                   
                 ACATGACGATAATTGCAGATAGAAACCATCAAAGACAAACCCCAAATCAACTAATAAT 
               
               
                   
                   
                 GTTTACAGATGTTCCCCCCCAAACCACAGAGCCTTACATCAAAACAAATACTGAAAG 
               
               
                   
                   
                 GCTTTAAACCAGGAACAGCTCGCCTTAACCCCACGAGGGTGCACACAAGCTGGGCT 
               
               
                   
                   
                 TTTTCTCTCGGTCTGAATGGTAAAGGGAGGAGGATACTCTAGCTCCTCCAGGTGGAT 
               
               
                   
                   
                 TGCTGAGACAGGGCTCGGCTCACACACTGTCTCTGCGCCTCTCCCAAATCTGGAGA 
               
               
                   
                   
                 ACTCTCCCAGCCTCCTGGTAAAGTGTCTCTGTGGGGCACTTAACGATAAAACAGCTT 
               
               
                   
                   
                 CTGCTGTAAAGCTCATTAGGAAAGAGCTAGCCTGCAACCTCCACGGAGTGGGAACT 
               
               
                   
                   
                 ACATCAGGCATTTTGCTAACTGCTGTATCCTAGGCCAATAAATGTTGATCACATTTAT 
               
               
                   
                   
                 AGCTGCCATGGTAGGGTGGGGACCCCTGCTATCTATCTGTGGAGGCTCTGGGAGCC 
               
               
                   
                   
                 CCTGACACAAACTTTCTGAAGCAGAGCCTCCCCAACCCCTTTTCCATTCCCTATACCT 
               
               
                   
                   
                 GACAGATGGCCCAGGAACCCATTAGAAATGGAAGGTCACTGCAGCAGTATGTGAAT 
               
               
                   
                   
                 GTGCGTGTGGGAGAAGGGCAGGATCAGAGCCCTGGGGGTGTGGCAGCCCCCAAGT 
               
               
                   
                   
                 GATTCTAATCCAGATCCTAGGGTTGTTTCCCTGTCCCATTGAAATAGCTGCTTTAAGG 
               
               
                   
                   
                 GGCCTGACTCAGGGAAATCAGTCTCTTGAATTAAGTGGTGATTTTGGAGTCATTTAG 
               
               
                   
                   
                 ACCAGGCCTTCAATTGGGATCCACTAGTTCTAGAGCGGCCGGGCCCAGGGAACCCC 
               
               
                   
                   
                 GCAGGCGGGGGCGGCCAGTTTCCCGGGTTCGGCTTTACGTCACGCGAGGGCGGCA 
               
               
                   
                   
                 GGGAGGACGGAATGGCGGGGTTTGGGGTGGGTCCCTCCTCGGGGGAGCCCTGGG 
               
               
                   
                   
                 AAAAGAGGACTGCGTGTGGGAAGAGAAGGTGGAAATGGCGTTTTGGTTGACATGTG 
               
               
                   
                   
                 CCGCCTGCGAGCGTGCTGCGGGGAGGGGCCGAGGGCAGATTCGGGAATGATGGC 
               
               
                   
                   
                 GCGGGGTGGGGGCGTGGGGGCTTTCTCGGGAGAGGCCCTTCCCTGGAAGTTTGGG 
               
               
                   
                   
                 GTGCGATGGTGAGGTTCTCGGGGCACCTCTGGAGGGGCCTCGGCACGGAAAGCGA 
               
               
                   
                   
                 CCACCTGGGAGGGCGTGTGGGGACCAGGTTTTGCCTTTAGTTTTGCACACACTGTA 
               
               
                   
                   
                 GTTCATCTTTATGGAGATGCTCATGGCCTCATTGAAGCCCCACTACAGCTCTGGTAG 
               
               
                   
                   
                 CGGTAACCATGCGTATTTGACACACGAAGGAACTAGGGAAAAGGCATTAGGTCATTT 
               
               
                   
                   
                 CAAGCCGAAATTCACATGTGCTAGAATCCAGATTCCATGCTGACCGATGCCCCAGGA 
               
               
                   
                   
                 TATAGAAAATGAGAATCTGGTCCTTACCTTCAAGAACATTCTTAACCGTAATCAGCCT 
               
               
                   
                   
                 CTGGTATCTTAGCTCCACCCTCACTGGTTTTTTCTTGTTTGTTGAACCGGCCAAGCTG 
               
               
                   
                   
                 CTGGCCTCCCTCCTCAACCGTTCTGATCATGCTTGCTAAAATAGTCAAAACCCCGGC 
               
               
                   
                   
                 CAGTTAAATATGCTTTAGCCTGCTTTATTATGATTATTTTTGTTGTTTTGGCAATGACC 
               
               
                   
                   
                 TGGTTACCTGTTGTTTCTCCCACTAAAACTTTTTAAGGGCAGGAATCACCGCCGTAAC 
               
               
                   
                   
                 TCTAGCACTTAGCACAGTACTTGGCTTGTAAGAGGTCCTCGATGATGGTTTGTTGAA 
               
               
                   
                   
                 TGAATACATTAAATAATTAACCACTTGAACCCTAAGAAAGAAGCGATTCTATTTCATAT 
               
               
                   
                   
                 TAGGCATTGTAATGACTTAAGGTAAAGAGCAGTGCTATTAACGGAGTCTAACTGGGA 
               
               
                   
                   
                 ATCCAGCTTGTTTGGGCTATTTACTAGTTGTGTGGCTGTGGGCAACTTACTTCACCTC 
               
               
                   
                   
                 TCTGGGCTTAAGTCATTTTATGTATATCTGAGGTGCTGGCTACCTCTTGGAGTTATTG 
               
               
                   
                   
                 AGAGGATTATAAGACAGTCTATGTGAATCAGCAACCCTTGCATGGCCCCTGGCGGG 
               
               
                   
                   
                 GAACAGTAATAATAGCCATCATCATGTTTACTTACATAGTCCTAATTAGTCTTCAAAAC 
               
               
                   
                   
                 AGCCCTGTAGCAATGGTATGATTATTACCATTTTACAGATGAGGAACCTTTGAAGCCT 
               
               
                   
                   
                 CAGAGAGGCTAACAGACATACCCTAGGTCATACAGTTATTAAGAGAAGGAGCTCTGT 
               
               
                   
                   
                 CTCGAACCTAGCTCTCTCTCTCTCGAGTAATACCAGTTAAAAAATAGGCTACAAATAG 
               
               
                   
                   
                 GTACTCAAAAAAATGGTAGTGGCTGTTGTTTTTATTCAGTTGCTGAGGAAAAAATGTT 
               
               
                   
                   
                 GATTTTTCATCTCTAAACATCAACTTACTTAATTCTGCCAATTTCTTTTTTTTGAGACAG 
               
               
                   
                   
                 GGTCTCACTCTGTCACCTAGGATGGAGTGCAGTGGCACAATCACTGCTCACTGCAG 
               
               
                   
                   
                 CCTCGACTTCCCGGGCTCGGGTGATTCTCCCCAGGCTCAGGGGATTCTCCCACTTC 
               
               
                   
                   
                 AGCCTCCCAAGTAGCTGGGACTACAGGTGCGCACCACCATCCCTGGCTAATATTTGT 
               
               
                   
                   
                 ACTTTATTTTATTTATTTATTTATTTATTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCG 
               
               
                   
                   
                 GGCTGGAGTACAGTGGCATGATCTCGGCTCAGTGCAACCTCTGCCTCCCGGGTTCA 
               
               
                   
                   
                 AGCGATTCTCCTACCTCATCCCCCTGAGTAGCTGGGATTACAGGCGCCTGCCACCA 
               
               
                   
                   
                 TGCCTGGCTAATTTTTTGTATTTTTAATAGAGACGAGGTTTCACCATGTTGGCCAGGC 
               
               
                   
                   
                 TACTCTCGAACTCCTGATCTCAGGTGATCCACCCGCCTTGGCCTCCCAAAGTGCTGG 
               
               
                   
                   
                 GATTACAGGCGTGAGCCACTGCGCCCGGCCTAATATTTGTATTTTTTGTAGAGATGG 
               
               
                   
                   
                 TGTTTTGCCATGTTGTCCAGGCTGGTCTTGAACTCCTGAGCTCAAGCGATCTGCCCG 
               
               
                   
                   
                 CCTCTGCTTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGTGCCTGGCCTAGG 
               
               
                   
                   
                 TAGACGCTTTTAGCTTTGGGGTGTGATGCCTGCCCCAGTATATAGTGAATTTAATTAT 
               
               
                   
                   
                 TGCTAGAGCTGGCTGTTTGTTAGTTTTCTTTGAACATAAGATACTCATTGTTTTTAGTT 
               
               
                   
                   
                 TGCAAATCCCTCTTCCTTTTTAAAAAATTTCTTTCCCTTAAATTGTTTGCATGTTAGCA 
               
               
                   
                   
                 ATAACAAATGCTTAAATGGTGCTATGTGCTAGATACTCTTCTAAGCCCTGTTATGTAT 
               
               
                   
                   
                 ATTAACTAATTTTTTAAATTACACAAATCAGAGAGGTTAAGTAACTTGCCCAAGATTAC 
               
               
                   
                   
                 CCAACAATACTAGGATTTGAACCTAAGTTTGTCTCACCCCAGATTCTGCTCTTAATCT 
               
               
                   
                   
                 CTAAACTTTTAAGTTAGTAGTGACAATAGTAGGTATTTATTGAATACTTAACTATGTTT 
               
               
                   
                   
                 TAGGCGTTGAAGTAAATATTTTGCAGGCATTATCTAATGTAAACACCCTAAAGTTACA 
               
               
                   
                   
                 TAACAGGTACCCTTTAGGTAAATAAACACTAGTATGACCTTGGAGGCACAGATAGTT 
               
               
                   
                   
                 GAAGTAACTTGCCCAATATCACTTACATGAAATTGGCCCTCAAATGTGTCTGATACAA 
               
               
                   
                   
                 CCCATGCTGCTTGTAACTATCGTTTTAAACTGCCAGGGTAAACTTGGACACACTTGA 
               
               
                   
                   
                 GCTAAGAAAAAGCTTTTAGATTTTTGCAAATTAATGTGAAAGATATGCTTTATGTGGAT 
               
               
                   
                   
                 ATAATATCTTCTAAATTTCGGGGATGGTAGTCCTAGAAATGTAATCCTGCCCTAGCCG 
               
               
                   
                   
                 AGCTTACCCTGCCAATAATTTTTTACAGAATTGGTAAAACGGAGCACCTTTTTTTTGT 
               
               
                   
                   
                 CCTTGGCCACACTGTTATCAACAGGGTGTAGATTGACATCAATCTGTAGGTGTAAAC 
               
               
                   
                   
                 CAGAATTACTCTTTGTGACCACCAGGAAATAGAGCAGTTCAGTTCAGGGGTTTCTTT 
               
               
                   
                   
                 CTGTGAATTTAGCACTGTGACCTGCATACTACAAGTCTACTTTGTTTTCTATCCATTGT 
               
               
                   
                   
                 TTGTATCTGGGTATTGCAAAAGGTAGGAAAAGGACCAACCAGATCAGCAGAGAAGA 
               
               
                   
                   
                 GTTGCCTTGGAGTTTTCTTTTAGTTTTCTGCAGTTCATTAGATAGTAACTAGGCCATG 
               
               
                   
                   
                 TCATTTTACTCCCTTGTAGTGAAGATATGTTGAAGTTGTACTGGTATACTCTTCTACCT 
               
               
                   
                   
                 TTCTGTAATTTTATATTGTGTAGACTTGATAAAATTTATGTGTCAATCACCACCATTAA 
               
               
                   
                   
                 TATCAATATTGAGCCTCAATTCTTATTTTTCTGCCCAGTGGCTGCCAAATTACTAACAT 
               
               
                   
                   
                 TTACAATAATTCACTACTACTAAGATAATCTACTAGTTCGATCACATACTTCAAATTGT 
               
               
                   
                   
                 TATGGAACTACTGTCTTCAGCATTGTGCTTCTGATAACTGATAAGTATAATTTTTTTTT 
               
               
                   
                   
                 TGTCCAGAGTGAACATGTCTATTCTTCCACTGTACACACTAATAAAAGGAAAAATTGT 
               
               
                   
                   
                 AATATTGGGTAAATTCATGTCCTTACACATGTAGTAGTTATGAGCCCATGTCCCTAGA 
               
               
                   
                   
                 ATGAGTAATAATTTATCCCTCCCTTGGTTGAATAGTCAAGAATGCTGATTTTAATTCTT 
               
               
                   
                   
                 CTAACAGCTTTATCCCTCAGAAGGGAAGGCAAGCAAGTTATATATGTAGTTTATTTGT 
               
               
                   
                   
                 AAGACTGATATGAAATTGGAAGATGAATCTACTATTAGCTTTAATTATTTTTACATTTA 
               
               
                   
                   
                 GGAATATTGCATCAGTAACTCATAATTTTGGTTTTCTGTTATCCTGAGTTAACACAAAT 
               
               
                   
                   
                 TATCCAAGGAGATGGCGGATCATCTGCTTTGAGGTGTTTTTTTTTGAGAATTTTAATG 
               
               
                   
                   
                 TATCTGAATATAAAAGGTAAAAATATGCCAACTAGCAATTTCTGCCCATTCCAGAAGT 
               
               
                   
                   
                 TTGGAAATATTACTCATTACTAGGAATTAAATAAAATATGGTTTATCTATTGTTATACCT 
               
               
                   
                   
                 CTTTTAATTCACATAGCTCATTTTTATCTTTTATTTTTGTTTGTTTTTTTTGAGATGGAG 
               
               
                   
                   
                 TCTTGCTCTGTCACCAGGCAGGAGTGCAGTGATGCAAATCTCGGCTCACTCTAGCCA 
               
               
                   
                   
                 CCGACTCCCTGGTTCAAGCGATTCTCCTGCCTGAGCCTTCTGAGTAGCTGGGATTAC 
               
               
                   
                   
                 AGGCAGGCACCACCACGCCCAGCTAATTTTTGTAGAGACAGGATTTCACCGTGTTG 
               
               
                   
                   
                 GCCAGGATGGTCTCCATCTCCTGACCTCATGATCTGCCTGCTTCGGCCTCCCAAAGT 
               
               
                   
                   
                 GCTGGGATTACAGGTGGGAGCCACTACGCCTGGCCCACATAGCTCATTTTTAGACT 
               
               
                   
                   
                 CACTTCCATTAAGTCTTGTTTGGACCCACGAACATTGTCTTTTTTTTTTTAAGATGGAG 
               
               
                   
                   
                 TTTCACTTTTGTTGCCCAGACTGTAGTGCAATGGTGCAATCTCAGCTCACTGCAATCT 
               
               
                   
                   
                 CTGCCTCCTGGGTTCTAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAATTAC 
               
               
                   
                   
                 AGGCGCCCGCCACCACGCCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGGGTTTCA 
               
               
                   
                   
                 CCATGTTGGGCAGGCCAGGGGTGATCCGCCCACCTCAGCCTCCCAAAGTGCTGGG 
               
               
                   
                   
                 ATTACAGGTGTGAGCCACCGCATCTGGCCAACATGTCTTTTTTTTTTTTTTCCTTTTTA 
               
               
                   
                   
                 ACCACAAAGAGACTTAAGCAGTCCTTGTCACAGATGATGAATTGATGTTGCAAGTATT 
               
               
                   
                   
                 GTCTTAGCTTGGATTAATTTTCTTGCTTACTGTAATTTTAGATAATATAGCTTTGTAATT 
               
               
                   
                   
                 AGAGATTTTATGTGTAAACCACAAAAATGTTTACATGAAGGCCATTATTACAGATGTG 
               
               
                   
                   
                 ACGTGCATAATTATTAGTAATTTGTATGTTTACATGGGTCAGTCTGGCAAAAAATTAT 
               
               
                   
                   
                 GAAGTTTTAAAAATTAAAAAAAATTATAATGCCAGTTTTACTGGAAAGTAAAATTATTT 
               
               
                   
                   
                 CAGTAATCGATTATAGCAAAAGTATTGATTTTCATTCCAGACAAAAGTCAGAATGAAA 
               
               
                   
                   
                 GGTAATTTCTCAATACTCTTTCAGATTAATAAAAGTACCTGTAGCGATTTTTATCATTC 
               
               
                   
                   
                 ACAAGTATATCACAAGTAAGTTAGAATTTGAGAACTGTGTTCTAGATCTCTGAGGAGA 
               
               
                   
                   
                 TGCAGTCAGATTTCTGAACTGTCTCAGCAAATGGTAAGTAACTTAGAGCTAGTAATTA 
               
               
                   
                   
                 ATAACCTGTCCTTTGATTTCTGATTCAGCCAAGAATGGCCATATTTGGGAAAGGCAG 
               
               
                   
                   
                 ATCTGGAGAGTAACCACGTTTTCATTCATTTACCACTTCTAGGCCCCTCCAGAGCTCT 
               
               
                   
                   
                 CAGATATTTTGGGGTTGAGCCCTTCCCCAAAGCCATACAGGACCTTTTTTTTGTGATC 
               
               
                   
                   
                 TGTTCTAGCCATTTTTATGTTGGGTGCTTGTTATGGACTGAGCATTTATGTCCTCCCA 
               
               
                   
                   
                 CACCCCCCCCATACCTTTTTTGAAGTCCTAACCCCCAGTGTGATGGTATTTGGAGAC 
               
               
                   
                   
                 AGGGCCTTTGGAAGGTAATTACAGTTAGAAGAAGTCGGGAGGGTTGGGCCCAGGTC 
               
               
                   
                   
                 TGATTGGATTAGTGCCCTTATATGAAAAGACACCAGGACGGGCGCAGTGGCTCACA 
               
               
                   
                   
                 CCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACGAGGTCAGGAGTT 
               
               
                   
                   
                 TGAGACCAGCCTGGCCAATGTAGTGAAACACCATCTCTACTAAAAATACAAAAATTAG 
               
               
                   
                   
                 CTGGGTGTGGTAGCGGGCTCCTGTCATCCAAGCTACTCGGGAGGGTGAGGCATGA 
               
               
                   
                   
                 GAATCACTTGAACCCGGGAGTTGGAGGTTGCAGTGAGCCCAGATTGTGCCACTGTA 
               
               
                   
                   
                 CTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAGAAAAAAAAAAAAAAAG 
               
               
                   
                   
                 AGACACCAGAGAGCTTGTTAGAAGAGGTCATGTGAGCACACAGTTAGAAGACCTTCA 
               
               
                   
                   
                 AGCCAAAGAAGAGGCCTGAGATTGAAACCTACCTTGCAGGTACCTTAATTTTGGACT 
               
               
                   
                   
                 TCCCAGCCTCCAAAACTGTGAGAAATAAGTTTCTGTTAAGTCACTCAGTCTGTGGTAT 
               
               
                   
                   
                 TTTGTTATGGCAGCCTGAGCAGGTAGTTGTTCTTTCAGAAGGTGTTGATAATAACCAC 
               
               
                   
                   
                 ATGCAACACCAAGTCACAAATAATAAAACAGATGTAACTTATATTCATACAGAAAGTT 
               
               
                   
                   
                 GGGCACTGCCATTGCCTTGTTGGTTTACACGGCTGTGCTAGTTCAGTAGCAGAAAG 
               
               
                   
                   
                 GTGCTGGTCTCCTTTACTCAGTTTACAATCTAGGCAGTAGAATGTAATCACTGCTTTA 
               
               
                   
                   
                 AACTTGATACTGCTTAGGGAGAGAATCATTGGTGCTGGGTAACTTTGGGTTCTAGGT 
               
               
                   
                   
                 TTACTTTTTGTGTATATATAACTGTTTTTGGTAAATCACAAGTTTCTGGGCTTGTCGAA 
               
               
                   
                   
                 TTAGATTTTGTTACAGATTATGAGCTTTATTATGCTATACAGTTAGTTGTATGTATATAT 
               
               
                   
                   
                 GCCTTTCCCACTAGATTTTAAGCTTTTTTTTTTTTTTTTTTTTTGTGACGGAGTCTTGCT 
               
               
                   
                   
                 CTTGTCGCCCAGGCTGAAGTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAGCCT 
               
               
                   
                   
                 CCACCTCCTAGGTTCAAGCGATTCTCCTGCCTCGGCCTCCCAAGTAACTGGGACTAC 
               
               
                   
                   
                 AGGCACGTGCCACCACACCCGGCTAATTTTTGTATTTTTTGTAGAGACAGGGTTTCG 
               
               
                   
                   
                 CCATGTTGGCTAGGCTGGTCTTGAACTTCTGGCCTCAGGTGATCCACCCGCCTCAG 
               
               
                   
                   
                 CCTCCCAAAGTGCTGGGATTTACAGGCATGAGCCACCACGCCCAGCTATAGCTCTTT 
               
               
                   
                   
                 AAGGGTTGTAAATTTATAATCATTCTTTTACTCTCCTGCAAATTCTGTTGCACACTGCC 
               
               
                   
                   
                 TTAATCAAGGTAGATGCTGAATGCATTTTTGTATAATTGAATATGTTGCAATCCCCAA 
               
               
                   
                   
                 CTCTCTCCAACTGTTCCTGTCAAAGCAGCCACTGGATTGTTAACTAATCCATATTAGA 
               
               
                   
                   
                 TGGGGTTAATTAATATCAGATGGGACAAGTAAGGGCTAATAAGATTATAGGCCACCA 
               
               
                   
                   
                 AGTAGATTTCTGTCTAGCTCTTATAGAGATTGAGTTTATTGGACCTGTTTGATAGGAA 
               
               
                   
                   
                 GTTTTGGTGTTTGGGATGATTAAAACTGAAGTTCCTATTTATTGAATTATACCTATTTA 
               
               
                   
                   
                 TATTATTTCATATCAGTGGTCCACATGCAAGTGAGGCTTCTGAGACAGAGTTTGAGTT 
               
               
                   
                   
                 CTCTCTTCAACTACCATAACACTTAACCTGTATCTTTTTTTTTTTTTTTTTTTTTAGACA 
               
               
                   
                   
                 GGAGTCTCGCTCTGTCACTCAGGCTGGAGTGTAGTGGTATGATCTCGGCTCACTGT 
               
               
                   
                   
                 AACCTCTGCCTCCTGGATTCAAGCAGTTCTCCATGTCTCAGCCTCCCTAGTAGCTGG 
               
               
                   
                   
                 GATTACAGGCCTGTGCCACCATGCCTGGCTAATTTTTTTTTTGTATTTTTAGTAGAGA 
               
               
                   
                   
                 CGGGGTTTTACCACGTTGGCCAGGCTGGTCTCGAACTCTTGACCTCGAGCGATCAA 
               
               
                   
                   
                 CTTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACAGCGCCCAGCC 
               
               
                   
                   
                 GTCTTTTTTTTTAAATAGCAATTTAACACTGTTCACAGTTACTCATGTACATGTCATGC 
               
               
                   
                   
                 CATCTATTACACTGTAAGTTCTGTGAGGGTAGCTGTATCAAATTTATCTAACTCTCTCT 
               
               
                   
                   
                 AGTATGCATGACATAGTAAGTATTCAATAAATATTTGCATATTAGTGATAAGGATACA 
               
               
                   
                   
                 GGTTCTGAATAGTGGGTCCTTACCATTTAAGAATTAGTATTTGATGGCCGGGCGGGG 
               
               
                   
                   
                 TGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGATCATGAGA 
               
               
                   
                   
                 TCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAATCCCGTCTTTACAAAAAAAA 
               
               
                   
                   
                 TACAAAAGAATTAACCAAGTGTGGTGGTGGGTGCCTGTAGTCCCAGCTACTGCTTTG 
               
               
                   
                   
                 TGAGGCTGAGGCAGGCAGATCACCTGAGGTGGGAAATTCAAGACCAGCCTGACCAA 
               
               
                   
                   
                 CATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCGGGCGTGGTGGCGCAT 
               
               
                   
                   
                 GTCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGG 
               
               
                   
                   
                 AGGCGGAGCTTGCAGTGAGCCAGGATCGCGCCACTGCACTCCAGCCTGGGCGACA 
               
               
                   
                   
                 GAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAATTAGTATTTGATATTTGAT 
               
               
                   
                   
                 CATTAAATATGAATTAAGAGGACTTAGACTTTTTGTTAAATGTCAAGCTGGGAAAAGT 
               
               
                   
                   
                 TGTCATTTAAATGAATTGCCTCTTATTTAATTTCGTCTGATGATACATTTTGTTTTTATT 
               
               
                   
                   
                 TTGTAAAAAATTATTTTTTTTCTTTTTGGAGACAGGGTCTTGCTCTGTTGCCCAGGCT 
               
               
                   
                   
                 GGTCACAAACTCCTGACCTCAAGCAATCCTCCTGCCTTAGCCTCCCAAAATGCTGGG 
               
               
                   
                   
                 ATTACAGGCGTGACGACCTCGCCCGGCCTTGTATTATGATACATTTTGAACAACTAC 
               
               
                   
                   
                 AAGTAGACTTGGTATAATGAACCTGCACGTACCCATTGCCAAGTTCTGACAACTGTC 
               
               
                   
                   
                 TGTCTATAGCCAATTATGCATTTCTTAAATTAGAACCCCCCCAATATACCCAAATATAT 
               
               
                   
                   
                 ATATATGTGTGCATATATATAGTAAGTTGTAACAAAGTTGTGAATTCATACCTGAAGTA 
               
               
                   
                   
                 TCTCAAGTGATGCAAGTTTTATGAATTTTTGTTTATGCCTTTTGGGAAGAGTTGTATTG 
               
               
                   
                   
                 ACAAATTTTTTATGCTTAAAGTAAACCATAAATCAAAAAAATAAAATCTAGGATGCAAT 
               
               
                   
                   
                 AAAACAAAACAACTTCTTGACATAAGTATGGTATGTAAATCTGTTTTGATTGGAAATCA 
               
               
                   
                   
                 ATTTGTTATATTGCCAGAATTCCTGTTTTAGAATACATCTCTGCTGATCTGTCTGTATT 
               
               
                   
                   
                 CTTAGACTGCATATCTGGGATGAACTCTGGGCAGAATTCACATGGGCTTCCTTTGAA 
               
               
                   
                   
                 ATAAACAAGACTTTTCAAATTCTTAGTCGATCTGCAGAACCTGTAGCCAGGCACTGAA 
               
               
                   
                   
                 CCATTTTGATAGATGCAGTAATCGTTGCAAGTGTATATTTCAAGGGAGTTCTGGCTG 
               
               
                   
                   
                 GGTCCTAGTTTATGCTTGTGGCAGAAGCAGTGAGTAACTGGGAGGAAGTTGGTGAG 
               
               
                   
                   
                 TAAGCTTCAAGGAAGAAGTCATTTTTAGTACTCTGGATCTTCCTGATTTTAAAGCACT 
               
               
                   
                   
                 ACAAAATGGTGCATTTTCATTCTTGTCAAGTGATAACAGATATATTCTGATGAGCCTG 
               
               
                   
                   
                 AAATGAATATATATTGTATCATTTTTATAATATCTAGCAAGGTTTGTATTTTCCTAGAAC 
               
               
                   
                   
                 TTGAACTAAATTTCAGTTCATAAAATTTATAAAATACTTAGTTGTTGTAAAATATTTTTG 
               
               
                   
                   
                 GAATGTTCACATAGGTGACACACAAATGTCCCATTTTCATTCTTTCTATAGTAAATATG 
               
               
                   
                   
                 TTCTGATATGTGAAGGTTTAGCAGATGCATCAGCATTTAATCCTAGAGGATCTGGCAT 
               
               
                   
                   
                 AATCTTTTCCCCCAAGAATAGAAATTTTTTCTGCTTATGAAAGTAGTACATGTTTCTTT 
               
               
                   
                   
                 AAAAACAAATCAATATTGACTTCTGCCTGCTGTATAGCACTATGCCTCCACCTGGCCA 
               
               
                   
                   
                 TGACCAGGGGCATGTCCTGGTCCACCTACCTGAAAATGTTTGCAACCAGCCTCCTG 
               
               
                   
                   
                 GCCATGTGCACAGGGGCTGAAGTTGTCCCACAGGTATTACGGGCCAACCTGACAAT 
               
               
                   
                   
                 ACATGAAGTTCCACCAAAGTCTGAGAACTCAGAACTGAGCTTTGGGGACTGAAAGAC 
               
               
                   
                   
                 AGCACAAACCTCAAATTTCTCAGCACTGGAAACCTCAAAATATAACTGAATTCCATAA 
               
               
                   
                   
                 ATAAGATTTTAAGTCTTAAATATGTATTTTTAAATGTATTAAAAGTCAAGCTGCTTGTAT 
               
               
                   
                   
                 TTAAGCACCTAATACAATGCTTAGGTTGTAAAAGGAGATGCTCAATAGGTACTAACTG 
               
               
                   
                   
                 ATATATTGAGATTTAATTATGGTTTGACCAATATTTATTGGAAACCGCCAAAGCTTAAA 
               
               
                   
                   
                 TCATCAGCTTCTTGAATGTGATTTGAAAGGTAATTTAGTATTGAATAGCATGTGAGCT 
               
               
                   
                   
                 AGAGTATTTCATTCTTTCTGGTTTATTTCTTCAAATAGACTTTGAATATAATGGTGAAT 
               
               
                   
                   
                 GGGTATTATAAATTAACTAATAAAAATGACATTGAAAATGAAAAAATATATATATTAAA 
               
               
                   
                   
                 GTGTAGAAAGTGACCAGGCGTGGTGGCTCACACCTGTAATCCAAGCACCTTGGGAG 
               
               
                   
                   
                 GCTGAGGCAGGAGGATCTCTTGATCCCAGGAGTTCAAGACCAGCCTGGGCAACATA 
               
               
                   
                   
                 GCGAGACTTCGTCTCTAAAAAAAAAAAAGAGAGAGAAAAAAATTTTTTTTATTTAAAAA 
               
               
                   
                   
                 AAGTGTAGAAAGTGTCAAGACCCCACTTCTTACCATTATTTGGTATATTTCTCTATAC 
               
               
                   
                   
                 CCACCCACCCTTCCTCCTTACTCCCTCCCTCCCTTCCCAATCTTTTTATCTTTTTGTAT 
               
               
                   
                   
                 TCTGATTTTTTGTTTGTATATTTTGCTTTAATTTAATGTATCCTTTAAAAATTTCCCATA 
               
               
                   
                   
                 CATTTTATATGTATATATAAAAACGCATGCTGCCAAAGATAATTTATAAGAAAGACCAT 
               
               
                   
                   
                 TGAATTTTTTTAAAAGTGATATATATTCATTGAAAAAAATTTAGAATATATAGCAAAGCA 
               
               
                   
                   
                 ATAAAGAACTAAATAAAATTGCTGTAACTCCTCTTTCAAAGATAAGTGCTTTTATGATT 
               
               
                   
                   
                 TTGTTGTATTTTTTTCTGTATATAGGTACATATATAGTATTTATAAAGCTGTACTCATAG 
               
               
                   
                   
                 TACATTTTCACATCACAGGTACCATATCAGTGTTATTAAATATTTTGTATGCCAGGGG 
               
               
                   
                   
                 CTAGACATACCAAGACAACCAATATGTGGTTCTACTTAAATAATATTAGAGTATCTTTT 
               
               
                   
                   
                 ATGATGACACTTCATGAGTTGACTATAATAATCTTAGACTTCTAAGAGTTTGGGTTTTC 
               
               
                   
                   
                 AAAAGATCACTTAGCTTTTTTGGGTGATTTTTCCCCCTTACTGTGAGATGAGAGAGGC 
               
               
                   
                   
                 TGTTTGGATTTGGGATTGGGGTAGCGGGGACAGCAACTTTTCTTTTCTTTTTCTTTTT 
               
               
                   
                   
                 TATTTTGAGGTAGGGTATTGCTGTGTCACCCAGGCTGGAGTGCAGTGGTGTGATCTC 
               
               
                   
                   
                 GGCTCACTGCAACCTCCACCTCCCGGGCTCAGGTGATCCTCCTGCTTCAGCCTCCC 
               
               
                   
                   
                 AGTAACTGGGACTACAGGCGCGTGCCACATGCCTGGCTAATTTTGTATTTTTAGTAG 
               
               
                   
                   
                 AGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCTAACTCCTGACCTCAGGTGATA 
               
               
                   
                   
                 CGCCCACCTGGGCCTCCCAAAATACTGGGATTACAGGCATGAGCCGCTGCATCAGC 
               
               
                   
                   
                 CAGCAGTTTTTCTTGTGGTTTTTTTTGTTTGTTTTGTTTTGTTTTGTTTTTGAGATAGG 
               
               
                   
                   
                 GTCTTACTCTGTTGTCCACGCTGGAGTGCTGTGGTATGATCGTAGCTCACTGCAGCC 
               
               
                   
                   
                 TCAAACTCCTGGGCTCAAGTGATTCCTTCTGCCTCCGCCTCCCGAGTAGCTGGGACT 
               
               
                   
                   
                 ACAGGTATGCACCACCATACCTGGCAAATTTTTACAAAGTTTTTTGTAGGGACGGGG 
               
               
                   
                   
                 TCTTGCTACATTCCCCATGTCGGTCTTGAACTCCTGGCCTCAAGCAACTCTCCTGTC 
               
               
                   
                   
                 TCAGCCTCCCAAAGCACTGGGATTACAAGTGTGAGCCACCACACCATGCCAGTTTTT 
               
               
                   
                   
                 CCTGTTCAGTGTGATATTTTATCTTGTTAGACTACAGTGTGTTAAAACTTGTTTTACTA 
               
               
                   
                   
                 AATTTTCAAACATACTCAAAAGTGGAGAGAATAGTATAATGAATACCCGTATGTTCAT 
               
               
                   
                   
                 CACCCATGTTTAGAATATTATTAAATATAAAGATTTTGCTGCGTTTGTCTTAGCTCTTT 
               
               
                   
                   
                 AAAATTTTTCTTTTTCTCTTTGTGACCTAAAGGAAATTCCATATCTTATCACTTTACTTC 
               
               
                   
                   
                 TACATTCTTGACTAAGATGACTAAGACATATAGTTACATGGTTTTTTGTTTTGTTTTTG 
               
               
                   
                   
                 TTTTTTAAAGACGAAATCTCGCTCTTGTCCCCCAGGCTGGAGTGCAATGGTGCCATC 
               
               
                   
                   
                 TCAGCTCAGTGCAACCTCTGCCTTCTGGGTACAAGCGATTCTCCTGCCTCAGCCTCC 
               
               
                   
                   
                 CAAGTAGCTGGGATTACAGGCTCCTGCCACCACGCCTGGCTAATTTTTGTATTTTTA 
               
               
                   
                   
                 GTAGAGACGGCGGGGGGAGGTTTCACCATGTTGACAAGGCTGGTCTGGAACTCCTG 
               
               
                   
                   
                 ACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAG 
               
               
                   
                   
                 CCACCGCGCCCAGCCTGTTTTTTTGTTTGTGTGTTTTGTTTTTTTTGAGACAGAGTCT 
               
               
                   
                   
                 TGCTCTGTTTCCCAGGCTGGAGTGAAGTGGTGCCATCTCAGCTCAGAGACAGAGTC 
               
               
                   
                   
                 TTGCTCTGTTTCCCAGGCTGGAGTGAAGTGGTGCCATCTTGGCTCACTGCAACCTTC 
               
               
                   
                   
                 ACCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAG 
               
               
                   
                   
                 GCATGTGTCACCACACCCGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGATTTCAC 
               
               
                   
                   
                 CGTGTTGCCCAGGCTGGTCTCGAACTCCTGAGCTCAGGCAGTCTGCCTGCCTCAGC 
               
               
                   
                   
                 CTCCCAAAGTGCTGGGATTACACGTGTGAACCAACCCGCCCGGCCTGTTGTTTTCTT 
               
               
                   
                   
                 ACATAATTCATTATCATACCTACAAAGTTAACAGTTACTAATATCATCTTACACCTAAA 
               
               
                   
                   
                 TTTCTCTGATAGACTAAGGTTATTTTTTAACATCTTAATCCAATCAAATGTTTGTATCCT 
               
               
                   
                   
                 GTAATGCTCTCATTGAAACAGCTATATTTCTTTTTCAGATTAGTGATGATGAACCAGG 
               
               
                   
                   
                 TTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTG 
               
               
                   
                   
                 TTTATTCCTCATGGACTAATTATGGACAGGTAAGTAAGATCTTAAAATGAGGTTTTTTA 
               
               
                   
                   
                 CTTTTTCTTGTGTTAATTTCAAACATCAGCAGCTGTTCTGAGTACTTGCTATTTGAACA 
               
               
                   
                   
                 TAAACTAGGCCAACTTATTAAATAACTGATGCTTTCTAAAATCTTCTTTATTAAAAATAA 
               
               
                   
                   
                 AAGAGGAGGGCCTTACTAATTACTTAGTATCAGTTGTGGTATAGTGGGACTCTGTAG 
               
               
                   
                   
                 GGACCAGAACAAAGTAAACATTGAAGGGAGATGGAAGAAGGAACTCTAGCCAGAGT 
               
               
                   
                   
                 CTTGCATTTCTCAGTCCTAAACAGGGTAATGGACTGGGGCTGAATCACATGAAGGCA 
               
               
                   
                   
                 AGGTCAGATTTTTATTATTATGCACATCTAGCTTGAAAATTTTCTGTTAAGTCAATTAC 
               
               
                   
                   
                 AGTGAAAAACCTTACCTGGTATTGAATGCTTGCATTGTATGTCTGGCTATTCTGTGTT 
               
               
                   
                   
                 TTTATTTTAAAATTATAATATCAAAATATTTGTGTTATAAAATATTCTAACTATGGAGGC 
               
               
                   
                   
                 CATAAACAAGAAGACTAAAGTTCTCTCCTTTCAGCCTTCTGTACACATTTCTTCTCAA 
               
               
                   
                   
                 GCACTGGCCTATGCATGTATACTATATGCAAAAGTACATATATACATTTATATTTTAAC 
               
               
                   
                   
                 GTATGAGTATAGTTTTAAATGTTATTGGACACTTTTAATATTAGTGTGTCTAGAGCTAT 
               
               
                   
                   
                 CTAATATATTTTAAAGGTTGCATAGCATTCTGTCTTATGGAGATACCATAACTGATTTA 
               
               
                   
                   
                 ACCAGTCCACTATTGATAGACACTATTTTGTTCTTACCGACTGTACTAGAAGAAACAT 
               
               
                   
                   
                 TCTTTTACATGTTTGGTACTTGTTCAGCTTTATTCAAGTGGAATTTCTGGGTCAAGGG 
               
               
                   
                   
                 GAAAGAGTTTATTGAATATTTTGGTATTGCCAAATTTTCCTCTAAGAAGTTGAATCATT 
               
               
                   
                   
                 TTATACTCCTGATGTTATATGAGAGTACCTTTCTCTTCACAATTTGTCTCTTTTTTTTTT 
               
               
                   
                   
                 TTTTTTGAGACAAGGTCTCTGTTGCCCAGGCTGGGGTGCAGTGCAGCAGAATGATCA 
               
               
                   
                   
                 CAGTTCACTGCAGTCTCAACCTCCTGGGTTCAAGCGATCCTTCCACCTCAGCCTCCT 
               
               
                   
                   
                 GAGTAGCTGGGACTATAGGTGTGCGCCACCACTCCCAGCTAATATTTTTATTTTGTA 
               
               
                   
                   
                 GAAACAGGGTTCGCCATGTTACCCAGCCTCCCAAAGTGCTGGGATTACAGGCATGA 
               
               
                   
                   
                 GCCACTGGCCCAGTTTCTACAGTCTCTCTTAATATTGTATATTATCCAGAAAATTTCAT 
               
               
                   
                   
                 TTAATCAGAACCTGCCAGTCTGATAGGTGAAAATGGTATCTTGTTTTTATTTGCATTTA 
               
               
                   
                   
                 AAAAAAATTATGATAGTGGTATGCTTGGTTTTTTTGAAGGTATCAAATTTTTTACCTTA 
               
               
                   
                   
                 TGAAACATGAGGGCAAAGGATGTGATACGTGGAAGATTTAAAAAAAATTTTTAATGCA 
               
               
                   
                   
                 TTTTTTTGAGACAAGGTCTTGCTCTATTGTCCAGGCTGGAGTGCAGTGGCACAATCA 
               
               
                   
                   
                 CAGTTCACTCCAGCCTCAACATCCTGCACTAAAGTGATTTTCCCACCTCACCTCTCAA 
               
               
                   
                   
                 GTAGCTGGGACTACAGGTACATGCTACCATGCCTGGCTAATTTTTTTTTTTTTGCAGG 
               
               
                   
                   
                 CATGGGGTCTCACTATATTGCCCAGGTTGGTGTGGAAGTTTAATGACTAAGAGGTGT 
               
               
                   
                   
                 TTGTTATAAAGTTTAATGTATGAAACTTTCTATTAAATTCCTGATTTTATTTCTGTAGGA 
               
               
                   
                   
                 CTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCATCACATTGTAGCC 
               
               
                   
                   
                 CTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGATTACATCAAA 
               
               
                   
                   
                 GCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTAGATTTTATCAGACTGA 
               
               
                   
                   
                 AGAGCTATTGTGTGAGTATATTTAATATATGATTCTTTTTAGTGGCAACAGTAGGTTTT 
               
               
                   
                   
                 CTTATATTTTCTTTGAATCTCTGCAAACCATACTTGCTTTCATTTCACTTGGTTACAGT 
               
               
                   
                   
                 GAGATTTTTCTAACATATTCACTAGTACTTTACATCAAAGCCAATACTGTTTTTTTAAA 
               
               
                   
                   
                 ACTAGTCACCTTGGAGGATATATACTTATTTTACAGGTGTGTGTGGTTTTTTAAATAAA 
               
               
                   
                   
                 CTCCTTTTAGGAATTGCTGTTGGGACTTGGGATACTTTTTTCACTATACATACTGGTG 
               
               
                   
                   
                 ACAGATACCCTCTCTTGAGCTACATCGGTTTGTGGGGAGTCAAAAGTCCTTTGGAGC 
               
               
                   
                   
                 TAGGTTTGACAAATAAGGTGGGTTAACACTTGTTTCCTAGAAAGCACATGGAGAGCT 
               
               
                   
                   
                 AGAGTATTGGCGAATTGAAGAAATCCCCCTTTTTTTTTAACACACTTAAGAAAGGGGA 
               
               
                   
                   
                 CTGCAGGTATACTCAAGAGAGTAAGTCGCACCAGAAACCACTTTTGATCCACAGTCT 
               
               
                   
                   
                 GCCTGTGTCACACAATTGAAATGCATCACAACATTGACACTGTGGATGAAACAAAAT 
               
               
                   
                   
                 CAGTGTGAATTTTAGTAGTGAATTTCATTCATAATTTGATCGTGCAAACGTTTGATTTT 
               
               
                   
                   
                 TATTACTTTAGACTATTGTTTCTGATTTTATGTTGGGTTGGTATTTCCTGTGAGTTACT 
               
               
                   
                   
                 GTTTTACCTTTAAAATAGGAATTTTTCATACTCTTCAAAGATTAGAACAAATGTCCAGT 
               
               
                   
                   
                 TTTTGCTGTTTCATGAATGAGTCCTGTCCATCTTTGTAGAAACTCGCCTTATGTTCAC 
               
               
                   
                   
                 ATTTTTATTGAGAATAAGACCACTTATCTACATTTAACTATCAACCTCATCCTCTCCAT 
               
               
                   
                   
                 TAATCATCTATTTTAGTGACCCAAGTTTTTGACCTTTTCCATGTTTACATCAATCCTGT 
               
               
                   
                   
                 AGGTGATTGGGCAGCCATTTAAGTATTATTATAGACATTTTCACTATCCCATTAAAAC 
               
               
                   
                   
                 CCTTTATGCCCATACATCATAACACTACTTCCTACCCATAAGCTCCTTTTAACTTGTTA 
               
               
                   
                   
                 AAGTCTTGCTTGAATTAAAGACTTGTTTACGGTATCGATAAGCTTGATATCAAAACGC 
               
               
                   
                   
                 CAACTTTGACCCGGAACGCGGAAAACACCTGAGAAAAACACCTGGGCGAGTCTCCA 
               
               
                   
                   
                 CGTAAACGGTCAAAGTCCCCGCGGCCCTAGACAAATATTACGCGCTATGAGTAACAC 
               
               
                   
                   
                 AAAATTATTCAGATTTCACTTCCTCTTATTCAGTTTTCCCGCGAAAATGGCCAAATCTT 
               
               
                   
                   
                 ACTCGGTTACGCCCAAATTTACTACAACATCCGCCTAAAACCGCGCGAAAATTGTCA 
               
               
                   
                   
                 CTTCCTGTGTACACCGGCGCACACCAAAAACGTCACTTTTGCCACATCCGTCGCTTA 
               
               
                   
                   
                 CATGTGTTCCGCCACACTTGCAACATCACACTTCCGCCACACTACTACGTCACCCGC 
               
               
                   
                   
                 CCCGTTCCCACGCCCCGCGCCACGTCACAAACTCCACCCCCTCATTATCATATTGGC 
               
               
                   
                   
                 TTCAATCCAAAATAAGGTATATTATTGATGATGTTT 
               
               
                   
               
               
                 125 
                 HDAdTrio 
                 AAACATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGGGGGT 
               
               
                   
                   
                 GGAGTTTGTGACGTGGCGCGGGGCGTGGGAACGGGGCGGGTGACGTAGGTTTTAG 
               
               
                   
                   
                 GGCGGAGTGATGCCCCCCCTCGAGGTTCGACGGTATCGATAAGCTTGATTTAATTAA 
               
               
                   
                   
                 GGCCGGCCCCTAGGGGCGCGCCGTCGACGCGACAACTGTCTTATTACCCTGTTATC 
               
               
                   
                   
                 CCTACCTTAATTAACATTTCCATACCACATTTGTAGAGGTTTTACTTGCTTTAAAAAAC 
               
               
                   
                   
                 CTCCCACACCTCCCCCTGAACCTGAAACATAAAATGAATGCAATTGTTGTTGTTAACT 
               
               
                   
                   
                 TGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAAT 
               
               
                   
                   
                 AAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTA 
               
               
                   
                   
                 TCATGTCTGGCCAGCTAGCTAGTCAAGCGTAATCAGGCACATCGTATGGATAGCCG 
               
               
                   
                   
                 GCATAATCTGGCACGTCATAAGGGTAGCCGGCGTAGTCGGGCACATCATAGGGGTA 
               
               
                   
                   
                 GCTGCCCCCTCCGCCCTTGCCGGGGCTCAGGCTCAGGGACTTCTGGGTGTAGTGG 
               
               
                   
                   
                 TTGTGCAGGGCCTCGTGCATCACGCTGCAGCTGAACACGTTGCCCTGCTGCCACCG 
               
               
                   
                   
                 GCTCTTGTCCACGGTCAGCTTGGAGTACAGGAAGAATGAGCCGTCGCTGTCCAGCA 
               
               
                   
                   
                 CAGGGGGGGTGGTCTTGTAGTTGTTCTCGGGCTGGCCGTTGCTCTCCCATTCCACG 
               
               
                   
                   
                 GCGATATCGCTGGGGTAGAAGCCTTTCACCAGGCAGGTCAGGGACACCTGGTTCTT 
               
               
                   
                   
                 GGTCAGCTCGTCCCGGCTGGGGGGCAGTGTGTACACCTGGGGCTCGCGGGGCTG 
               
               
                   
                   
                 GCCCTTGGCCTTGCTGATGGTTTTCTCGATGGGGGCAGGCAGAGCCTTGTTGGACA 
               
               
                   
                   
                 CCTTGCACTTGTACTCTTTGCCGTTCAGCCAGTCCTGGTGCAGCACGGTCAGCACG 
               
               
                   
                   
                 GACACCACCCGGTAGGTGCTGTTGTACTGTTCCTCTCTGGGCTTGGTCTTGGCGTT 
               
               
                   
                   
                 GTGCACTTCCACGCCGTCCACGTACCAATTAAACTTCACTTCAGGGTCCTCGTGGGA 
               
               
                   
                   
                 CACGTCCACCACCACGCAGGTCACTTCGGGGGTCCGGCTGATCATCAGGGTGTCCT 
               
               
                   
                   
                 TGGGCTTTGGGGGGAACAGGAACACGCTAGGTCCGCCCAGCAGCTCAGGGGCAGG 
               
               
                   
                   
                 GCAGGGGGGACAGGTGTGGGTCTTGTCGCAGCTCTTGGCCTCTCTCTTGATTTCCA 
               
               
                   
                   
                 CCTTGGTGCCCTGTCCGAAGGTGGCGGGGTGGTACAGGTACTGCTGGCAGTAGTA 
               
               
                   
                   
                 GGTGGCGAAGTCTTCGGGCTGCAGGGAGCTGATGGTCAGGGTGAAGTCGGTGCCG 
               
               
                   
                   
                 GAGCCGCTGCCGCTGAATCTGCTGGGCACGCCGCTGTACAGGAAGCTGGCGCTGT 
               
               
                   
                   
                 AGATCAGCAGCTTGGGGGCCTTGCCGGGCTTCTGCTGATACCAAGCCACGGCGGT 
               
               
                   
                   
                 GGACACGTCCTGGCTGGCCCGACAGGTGATGGTCACTCTGTCGCCCACGCTGGCG 
               
               
                   
                   
                 CTCAGGCTGCTGGGGCTCTGGGTCATCTGGATGTCGCTGCCTCCGCCGCCTGATCC 
               
               
                   
                   
                 TCCCCCTCCGGATCCGCCTCCGCCAGCAGACACAGTCACCAGTGTGCCCTGGCCC 
               
               
                   
                   
                 CAGTAATCGAAGCCGCCAGGCCAGTGCCTTCTGGCGCAGTAGTACACAGCGGTGTC 
               
               
                   
                   
                 CTCGGCCCGCAGGCTGTTCATCTGCAGGTAGGCGGTGTTCTTGCTGGTGTCGGCGC 
               
               
                   
                   
                 TGATGGTGAACCGGCCCTTCACGCTGTCGGCGTAGTAGGTGCTGCCGCCGTAGGG 
               
               
                   
                   
                 GCTGATCCAGGCCACCCATTCCAGTCCCTTGCCAGGGGCCTGGCGCACCCAGTGG 
               
               
                   
                   
                 ATCCAGCTGTCGCTGAAGGTGAAGCCGCTGGCGGCGCAAGACAGTCTCAGGCTGC 
               
               
                   
                   
                 CGCCAGGCTGCACCAGTCCGCCGCCAGATTCCACCAGCTGCACCTCAGAGTGGGC 
               
               
                   
                   
                 GCCTGTGGCGGCTCCGACCAGGAACAGGATCCGCCAGATCCAGTCCATGGTGCCG 
               
               
                   
                   
                 GCGCTGAGGACAGTGCTCAGCGGTCCTTCGGCAGTCTCCGGGCCCAGCAACAGGC 
               
               
                   
                   
                 TTGTAGTCCCGGAGCGCGACGGCGTTCCGACCGATCTGAGGGCGACAGGAGCCCC 
               
               
                   
                   
                 CGATCAGGCGGAGCCACGAGACGGGCTCCGAGTTGGCCTGGAAAGGGCAGGCCG 
               
               
                   
                   
                 CGGCGCTTACCTCTCGGCCCCGCAGAGGCAGACGCTCCCGTCGCTGTGGTCTCGG 
               
               
                   
                   
                 CCCGTGTGGAGCGCGCCGCCGCCGACTCGGCTTATATACCCTCCCCCCAGCCCCG 
               
               
                   
                   
                 TCGTGGAGGCCTCCGATTGGCGAAGGCGCTCCTCGTTGGAGGACGCTGATTGGTC 
               
               
                   
                   
                 CATGCCACCAAGCTGGCCGCTGCCGATTCGAAGCGGCCTCCTCCGCAACTTACGTC 
               
               
                   
                   
                 ACTGCTACGCCCCCCGGGCTGACTCATTGGCTCTTGGTCACTCTCAACGGCCGCCA 
               
               
                   
                   
                 ATGAGGGGCAGCATCCGCCCTGTGCGCCGGTCCTATTGGTTCAGCAGCTGCCTGTC 
               
               
                   
                   
                 CCTCGGGTGACCTCTCAACCCGAGACCGTTTCCGCCGGTAACTAGTCAAAACAAACT 
               
               
                   
                   
                 CCCATTGACGTCAATGGGGTGGAGACTTGGAAATCCCCGTGAGTCAAACCGCTATC 
               
               
                   
                   
                 CACGCCCATTGATGTACTGCCAAAACCGCATCATCATGGTAATAGCGATGACTAATA 
               
               
                   
                   
                 CGTAGATGTACTGCCAAGTAGGAAAGTCCCATAAGGTCATGTACTGGGCATAATGCC 
               
               
                   
                   
                 AGGCGGGCCATTTACCGTCATTGACGTCAATAGGGGGCGTACTTGGCATATGATAC 
               
               
                   
                   
                 ACTTGATGTACTGCCAAGTGGGCAGTTTACCGTAAATACTCCACCCATTGACGTCAA 
               
               
                   
                   
                 TGGAAAGTCCCTATTGGCGTTACTATGGGAACATACGTCATTATTGACGTCAATGGG 
               
               
                   
                   
                 CGGGGGTCGTTGGGCGGTCAGCCAGGCGGGCCATTTACCGTAAGTTATGTAACGC 
               
               
                   
                   
                 CTGCAGGCAGCTTTCTATGCAACCCAAGGACTCAGTTTTTGGCCTGTTTTAGTGACA 
               
               
                   
                   
                 GGCAATCAGCAACATGCTGCATTTCTCTCCAGTGTTGTAATCAAAGAAACCCTCCCA 
               
               
                   
                   
                 TAGCTTTAAATGATATTCCTTCCCCTTCCAATTATGTGGGGGGAAAACAACCCTATTC 
               
               
                   
                   
                 TCCACCCAGAAGTGTTAACTCAAGAATTACATTTTCAAGAAGTTTCCAGATTCGTAAA 
               
               
                   
                   
                 ACCAGAATTAGATGTCTTTCACCTAAATGTCTCGGTGTTGACCAAAGGAACACACAG 
               
               
                   
                   
                 GTTTCTCATTTAACTTTTTTAATGGGTCTCAAAATTCTGTGACAAATTTTTGGTCAAGT 
               
               
                   
                   
                 TGTTTCCATTAAAAAGTACTGATTTTAAAAACTAATAACTTAAAACTGCCACACGCAAA 
               
               
                   
                   
                 AAAGAAAACCAAAGTGGTCCACAAAACATTCTCCTTTCCTTCTGAAGGTTTTACGATG 
               
               
                   
                   
                 CATTGTTATCATTAACCAGTCTTTTACTACTAAACTTAAATGGCCAATTGAAACAAACA 
               
               
                   
                   
                 GTTCTGAGACCGTTCTTCCACCACTGATTAAGAGTGGGGTGGCAGGTATTAGGGATA 
               
               
                   
                   
                 ATCCTAGGTTAGGAAGCATTCAGATAGCTCATCACTCTATCAATAGTCACTGCCCGA 
               
               
                   
                   
                 ATTCTGAAAGCATGAAGAAGTATGCAGAGCTTGATTTTAGTTTTATAAAAATCCGGTT 
               
               
                   
                   
                 CTTCAAGGGAGGATTTTTGTGGCACAGTCTCACTGTTGAAATTCAGGGCCTGCATCA 
               
               
                   
                   
                 GCTCATCAATAACTGCCAGCATGTTTTGATCTAGAAAGATCTGCCTCTTAGGATCCAT 
               
               
                   
                   
                 CAGCAGCTTTGCATTCATGGTCTTGAACTCCACCTGGTACATCTTCAAGTCTTCATAA 
               
               
                   
                   
                 ATACTACTAAGGCACAGGGCCATCATAAAAGAGGTCTTTCTGGAGGCCAGGCAACTC 
               
               
                   
                   
                 CCATTAGTTATGAAAGAGGTCTCTCTGGAATTTAGGCAACTCTCATTCTTGGTTAATT 
               
               
                   
                   
                 CCAATGGTAAACAGGCCTCCACTGTGCTGGTTTTATCTTTTGTGATATCTTCATGATC 
               
               
                   
                   
                 AATCTCTTCAGAAGTGCAAGGGTAAAATTCTAGAGTTTGTCTGGCCTTCTGGAGCAT 
               
               
                   
                   
                 GTTGCTGACGGCCCTCAGCAGGTTTTGGGAGTGGTGAAGGCATGGGAACATTCCTG 
               
               
                   
                   
                 GGTCTGGAGTGGCCACGGGGAGGTTTCTGGCGCCCACCCCAGGTACCCCTACTCC 
               
               
                   
                   
                 AGGAACACTGCAGGGCACAGATGCCCATTCGCTCCAAGATGAGCTATAGTAGCGGT 
               
               
                   
                   
                 CCTGGGCCCGCACGCTAATGCTGGCATTTTTGCGGCAGATGACCGTGGCTGAGGTC 
               
               
                   
                   
                 TTGTCCGTGAAGACTCTATCTTTCTTTTCTCTCTTGCTCTTGCCCTGGACCTGAACGC 
               
               
                   
                   
                 AGAATGTCAGGGAGAAGTAGGAATGTGGAGTACTCCAGGTGTCAGGGTACTCCCAG 
               
               
                   
                   
                 CTGACCTCCACCTGCCGAGAATTCTTTAATGGCTTCAGCTGCAAGTTCTTGGGTGGG 
               
               
                   
                   
                 TCAGGTTTGATGATGTCCCTGATGAAGAAGCTGCTGGTGTAGTTTTCATACTTGAGC 
               
               
                   
                   
                 TTGTGAACGGCATCCACCATGACCTCAATGGGCAGACTCTCCTCAGCAGCTGGGCA 
               
               
                   
                   
                 GGCACTGTCCTCCTGGCACTCCACTGAGTACTCATACTCCTTGTTGTCCCCTCTGAC 
               
               
                   
                   
                 TCTCTCTGCAGAGAGTGTAGCAGCTCCGCACGTCACCCCTTGGGGGTCAGAAGAGC 
               
               
                   
                   
                 CTCTGCTGCTTTTGACACTGAATGTCAAATCAGTACTGATTGTCGTCAGCCACCAGC 
               
               
                   
                   
                 AGGTGAAACGTCCAGAATAATTCTTGGCCTCGCATCTTAGAAAGGTCTTATTTTTGGG 
               
               
                   
                   
                 TTCTTTCTGGTCCTTTAAAATATCAGTGGACCAAATTCCATCTTCCTTTTTGTGAAGCA 
               
               
                   
                   
                 GCAGGAGCGAATGGCTTAGAACCTCGCCTCCTTTGTGACAGGTGTACTGGCCAGCA 
               
               
                   
                   
                 TCTCCAAACTCTTTGACTTGGATGGTCAGGGTTTTGCCAGAGCCTAAGACCTCACTG 
               
               
                   
                   
                 CTCTGGTCCAAGGTCCAGGTGATACCATCTTCTTCAGGGGTGTCACAGGTGAGGAC 
               
               
                   
                   
                 CACCATTTCTCCAGGGGCATCCGGATACCAATCCAATTCTACGACATAAACATCTTTC 
               
               
                   
                   
                 TTCAGTTCCCATATGGCCACGAGGGGAGATGCCAGAAAAACCAGGGAAAACCAAGA 
               
               
                   
                   
                 GATGACCAACTGCTGGTGACCCATGGTAAGCTTTCTAGATTCATGACGTGCGACCG 
               
               
                   
                   
                 GTGAGTCTCAAGTCCCCTTCGATCGCAGGAGCCGCCTCCACCCCCCACCCCTGGGT 
               
               
                   
                   
                 TCGGATCCTCACACCTCCAGCCGCGCGGTCCGCCCACTACACCCCAAGCAGGTCG 
               
               
                   
                   
                 GGCCGCTTTTCACCCCCACTTCTCGCGGGCGGGGGACGGGAAACATGAACCCACC 
               
               
                   
                   
                 AATCGCGCCGCACCACGCACCCACGGCACCCAATGAGGATTCGTGAGGGGGGGCG 
               
               
                   
                   
                 GAAGTCCACCAATCGGAGCTGTCCAGGTGCGGTGACCGATGCCCGAAGCGTGGCT 
               
               
                   
                   
                 CCTTCCGATTGGTCAGGGTTTGCAGCTTTTCTCCAATCAAATGGCTCCGCGGGCCCC 
               
               
                   
                   
                 TCACGCGTGGGACCGCCCCTTTGCCTGGGCGGCCTTGGCCTCTAAGGGAAAACGT 
               
               
                   
                   
                 CCAATGAATGTAAGCAGAGAACACATCCATCCTTTTAGAGAGGTCGCGGCGGAACTA 
               
               
                   
                   
                 CTTCCGGATCCTAGAGAGCGTTTATTCCGTGACCGGGGAAACGGTAGCCATGACAA 
               
               
                   
                   
                 CGTGTTCTTCACCCTTTCCCATCTATGCCTGGGGTTTCGTTGGAAGTGATTCCAGCA 
               
               
                   
                   
                 CGACTTTCGCGGCCAGCTTTCTCGTGTGGCGGCGCTTCTCGGAAAGAAGAAACACA 
               
               
                   
                   
                 CGAGAGAGGTTGCAAATCCCCTAGAACCCTTTCAGATGGCGGGGGGGCGGGGGGG 
               
               
                   
                   
                 TGGCGGTGGTGATGAAACTAGTGGGACTATGGTTGCTGACTAATTGAGATGCATGCT 
               
               
                   
                   
                 TTGCATACTTCTGCCTGCTGGGGAGCCTGGGGACTTTCCACACCTGGTTGCTGACTA 
               
               
                   
                   
                 ATTGAGATGCATGCTTTGCATACTTCTGCCTGCTGGGGAGCCTGGGGACTTTCCACA 
               
               
                   
                   
                 CCCTAACTGACACACATTCCACAGCTGGTTCTTTCAGCCTCAGAAGGTACCTAACCA 
               
               
                   
                   
                 AGTTCCTCTTTCAGAGGTTATTTCAGGCCCTGCAGGTTAATTAAGCTAGCCGACGCG 
               
               
                   
                   
                 TTGGCCAGGAGCTCAGATCTCCGGATCCAAGCTTATCGATTTCGAACCCAAATGGAT 
               
               
                   
                   
                 CTACCACATTTGTAGAGGTTTTACTTGCTTTAAAAAACCTCCCACACCTCCCCCTGAA 
               
               
                   
                   
                 CCTGAAACATAAAATGAATGCAATTGTTGTTGTTAACTTGTTTATTGCAGCTTATAATG 
               
               
                   
                   
                 GTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCAATAGCATCACAAAT 
               
               
                   
                   
                 TTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAA 
               
               
                   
                   
                 TGTATCTTATCATGTCGAGCTAGCTAGTCAGGACTTCAGTTCCAGCTTTGTGCCGGC 
               
               
                   
                   
                 TCCGAAGGTCAGCGGGTTGCTAGACCATTGCTGACAGTAATATGTGGCGGCATCCT 
               
               
                   
                   
                 CGGCTTCCATAGAGCTGATTGTCAGGCTGTAGCTGGTGCCAGATCCAGATCCGCTG 
               
               
                   
                   
                 AATCTGTAGGGCACGCCGGAGGCCACTTTGCTTGTGTCGTAGATCCACCGCTTGGG 
               
               
                   
                   
                 GCTTGTGCCAGACTTCTGCTGATACCAGTTCATGTAGGACACGCTGCTGCTGGCTCT 
               
               
                   
                   
                 GCATGTCATGGTCACTTTCTCGCCTGGGGAAGCGCTCATGATGGCGGGGCTTTGTG 
               
               
                   
                   
                 TCAGCTGAATATCGGAGCCACCACCACCGCTTCCACCACCACCTGAACCGCCTCCG 
               
               
                   
                   
                 CCACTAGAAACTGTCAGGGTTGTGCCCTGGCCCCAGTAATCCAGACAGTAGTGGTC 
               
               
                   
                   
                 GTCGTAGTACCGGGCACAATAGTACACAGCGCTATCTTCAGAGGTCAGGCTGGACA 
               
               
                   
                   
                 GCTGCATGTAGGCGGTAGAGCTGCTCTTGTCGGTGGTCAGTGTGGCCTTGTCCTTG 
               
               
                   
                   
                 AACTTCTGGTTGTAATTGGTGTAGCCCCGGCTGGGGTTGATGTAGCCGATCCATTCC 
               
               
                   
                   
                 AGTCCTTGGCCAGGCCTCTGCTTGACCCAGTGCATGGTGTACCGGGTGAATGTGTA 
               
               
                   
                   
                 GCCGCTGGTCTTGCAGGACATCTTCACAGAGGCGCCAGGTCTAGCCAGTTCGGCGC 
               
               
                   
                   
                 CAGACTGTTGCAGCTTGATATCGGATCCGCCACCTCCGCCAGATGACACTGTGACC 
               
               
                   
                   
                 AGTGTTCCTCTGCCCCAGTAGTCGAGGCCCTGTCTGGCGCAATAATACACGGCGGT 
               
               
                   
                   
                 GTCCTCGGCTCTCAGGGAGTTCATCTGCAGGTACAGGCTGTTCTTGGCGTTGTCCC 
               
               
                   
                   
                 GGCTGATGGTGAATCTGCCCTTGATGCTGTCCAGGTAGTAGGTGTAGCTGCCGCCG 
               
               
                   
                   
                 CTGCTGATTGTGGACACCCATTCAAGGCCTTTGCCAGGAGCCTGTCGGACCCAGCT 
               
               
                   
                   
                 CATATCGTAGCTGCTGAAGGTGAAGCCGGAAGCGGCACAGCTCAGTCTCAGAGAGC 
               
               
                   
                   
                 CGCCAGGTTTCACAAGTCCGCCGCCTGATTCCACCAGCTGCACTTCAGATCCACCA 
               
               
                   
                   
                 CCGCCACTACCTCCGCCTCCGCTTCCTCCGCCGCCAGATCCTCCGCCACCTCTCTT 
               
               
                   
                   
                 GATTTCCACCTTGGTGCCTCCGCCAAATGTCAGGGGATTGCTGGACCACTGCAGGC 
               
               
                   
                   
                 AGTAGTACACGGCGAAGTCCTCAGGTTCCAGGCTGCTTATGGTCAGGGTGAAATCG 
               
               
                   
                   
                 GTGCCGCTGCCAGAGCCAGAAAATCTGGCAGGCACTCCGCTGGCCAGATTGCTGGT 
               
               
                   
                   
                 CAGGTAGATCAGGATTCTAGGGGCCTGTCCGGGCTTCTGCTGCAGCCAGTAGATGT 
               
               
                   
                   
                 AGTTGATGGAGCTGCTGGCGCTACAGCTCAGGGTAGCTCTCTCGCCAGGGCTCAGA 
               
               
                   
                   
                 GACAGTGTGGCTGGAGACTGTGTCAGCACGATCTCGCCGGTGGTATCAGGCAGCCA 
               
               
                   
                   
                 AAGCAGCAGCAGGAACAGCAGCTGAGCAGGGGCTTCCATGGTGGCCCTCCTTCGC 
               
               
                   
                   
                 CGGTGATCTCAGCTGTAGGAAAGAGAAGAAGGTTAGTAGTCGACGTGTCCCTCTCG 
               
               
                   
                   
                 ATGAATCTAAGTATCAATTGTGAGCGCTCACAAGTCAACACTCTTTTTGATAAATCTA 
               
               
                   
                   
                 GTAGATATCACTTACGTAGGCGCCGGTCACAGCTTGGATCTGTAACGGCGCAGAAC 
               
               
                   
                   
                 AGAAAACGAAACAAAGACGTAGAGTTGAGCAAGCAGGGTCAGGCAAAGCGTGGAGA 
               
               
                   
                   
                 GCCGGCTGAGTCTAGGTAGGCTCCAAGGGAGCGCCGGACAAAGGCCCGGTCTCGA 
               
               
                   
                   
                 CCTGAGCTTTAAACTTACCTAGACGGCGGACGCAGTTCAGGAGGCACCACAGGCGG 
               
               
                   
                   
                 GAGGCGGCAGAACGCGACTCAACCGGCGTGGATGGCGGCCTCAGGTAGGGCGGC 
               
               
                   
                   
                 GGGCGCGTGAAGGAGAGATGCGAGCCCCTCGAAGCTTCAGCTGTGTTCTGGCGGC 
               
               
                   
                   
                 AAACCCGTTGCGAAAAAGAACGTTCACGGCGACTACTGCACTTATATACGGTTCTCC 
               
               
                   
                   
                 CCCACCCTCGGGAAAAAGGCGGAGCCAGTACACGACATCACTTTCCCAGTTTACCC 
               
               
                   
                   
                 CGCGCCACCTTCTCTAGGCACCGGTTCAATTGCCGACCCCTCCCCCCAACTTCTCG 
               
               
                   
                   
                 GGGACTGTGGGCGATGTGCGCTCTGCCCACTGACGGGCACCGGAGCGATCGCAGA 
               
               
                   
                   
                 TCCTTCGATAGAGAAATGTTCTGGCACCTGCACTTGCACTGGGGACAGCCTATTTTG 
               
               
                   
                   
                 CTAGTTTGTTTTGTTTCGTTTTGTTTTGATGGAGAGCGTATGTTAGTTACGATTCACAC 
               
               
                   
                   
                 AAAAAACCAACACACAGATGTAATGAAAATAAAGATATTTTATTGCGGCCGCTCGAGT 
               
               
                   
                   
                 CTAGAGGTATACATGCCATGGTCCGCGGTATTACCCTGTTATCCCTAAGACAACTGT 
               
               
                   
                   
                 CCTGCATGCGACGTCGGCGCGCCATCGAATTCCTGCAGCCCGGGGGATCCCTTTGT 
               
               
                   
                   
                 TGATTTTTTCCACATAGATTATTTTTGACTGTTTTGGCACTTTATATAAATGGAATCATA 
               
               
                   
                   
                 TAGTAAATATATACATGTATATATGTATATATACACTATATATGTATATATATAGTGTAT 
               
               
                   
                   
                 ATATATACATGTATATATGTATATTTACATATATACTGTATATATGTATATTTACATATAT 
               
               
                   
                   
                 ACTGTATATATGTATATATACACGTATATACTGTATATATACAGTATATACTGTATATAT 
               
               
                   
                   
                 ATACTGTATATATGTGTATATATATATACAGTATATATACAGTATACATATATATACATG 
               
               
                   
                   
                 TATATATACACAGTATATATACATGTATATATACACAGTATATATACATGTATATATACA 
               
               
                   
                   
                 CAGTATATATACATGTATATATACACAGTATATATACACTGTATATATGTATATATATAC 
               
               
                   
                   
                 TGTGTATATATATACAGTATATATACAGTATATATATACATGTATATGTATATATATACT 
               
               
                   
                   
                 GTATATATGTGTATATATACGTATATATACTGTATATATATATAGACACTTTTGTGTCT 
               
               
                   
                   
                 GGCTTCTTGCTCTCATCATAAAGCACTTGAAATCCATCCATGTTGTAGCTGGTATCAG 
               
               
                   
                   
                 TAGCTAGTTTCTTTTCATTGCTGAGAAGTATCACTTTTTATTGATGAGTAGTTTTACAT 
               
               
                   
                   
                 TGTATGAACATGCCCGAGTTTGTTTATGCATTCTACTAATAGACACCTGGGCTGTTTG 
               
               
                   
                   
                 CAGTTTTTGGCTATTACAAAGAAAATTTCTATATTTTTTTCCAACTTTTATTTTAGGTTC 
               
               
                   
                   
                 AGCGGGTACATGGGCAGGTTTGTTACATCGGTAAATTGCATGTCACTGGGGTTTGGT 
               
               
                   
                   
                 GTACAGATTATTTCACCACCCAGGTAATAAGCATAGTACCTGATAGGCAGGTTTTTGA 
               
               
                   
                   
                 TCCTCACCCTCCTCCCTCAAGTAGGCCCCAGTGTCTATTGTTCTATTCCTTTTTTTTTT 
               
               
                   
                   
                 TTTTGAGATGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCGATCTCG 
               
               
                   
                   
                 GCTCACTGCAAGGTCCACCTCCAGGGTTCAAGCGATTCTACTGCCGCAGCCTCCCG 
               
               
                   
                   
                 AGTAGCTGGGATTACAGGCACCCACCACCACGCCCGGCTAATTTTTGTATTTTTAGT 
               
               
                   
                   
                 AGAGACTGGGTTTCACCATGTTGGCCAGGATGGTCTCGAACTCCTCACCTCAGGTG 
               
               
                   
                   
                 ATCCGCCCGCTTCGGCCTCGCAAAGTACTGGGATTACAGGCGTGAGCCACGGTGCC 
               
               
                   
                   
                 TGGCCTATGGTTCCATTCTTTGTGTACACGTGTACTCAGTGTTTAGCTTCCACTTGTA 
               
               
                   
                   
                 AGTGAAAACATGCAGTATTTGGTTTTCTGAAATTCTTGTCTTCATCTTTTTGTAGACAA 
               
               
                   
                   
                 TCCACTACTTTTATTTTTAAATATTAGGAACAATAGCCTCTGTGTGTCCTGAATTGCAA 
               
               
                   
                   
                 TGTTTTTTCTCTGATTTTGCTGCTCATCTTGTAACCTGTATGGTGTTTTTCTGTGTGCA 
               
               
                   
                   
                 AGCTTTTTACTTTACGTGGGCAATTTTATCATTCTTTTCTTTTATGGTTTCTGGGTTTC 
               
               
                   
                   
                 ATGTCATGATTGGAGAAGCTTGATCTACCCTGATACTATAAAAATATCCACCTTGGCT 
               
               
                   
                   
                 TTTTTTTTTTTTTTTAGATGGATTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGC 
               
               
                   
                   
                 GTGATCTCGGCTCACCACAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCG 
               
               
                   
                   
                 GCCTCCTGAGTAGCTGGGATTACAGGCATGCGCCACCACGCTCAGCTAATTTTGTAT 
               
               
                   
                   
                 TTTTAGTAGAGACAGGATTTCACCATGTTGGTCAGGCTGGTCTTGAACTCCCCACCT 
               
               
                   
                   
                 CAGGTGATCTGTCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGACCCAC 
               
               
                   
                   
                 CACACCTGGCCCACGTTGTTTTCTGATAGTGTTTTCACGTGTTATTTTTTCTGTCTTAC 
               
               
                   
                   
                 TCTTTGAATCATCTAAATGTATCTTAATGTCAGGAGTGAGGTAGAGGACCCAGTTGTT 
               
               
                   
                   
                 TGGTTTAAATGACTAGCCAGTTTTCCCAACACCAGGTGTTGAACATCCCTCACTGAT 
               
               
                   
                   
                 GTGAGATGCTGCCTTTTTCACAGTCTCAATCCCCATGTGCATTTCTATTTATTTTCCTT 
               
               
                   
                   
                 CCACTTTATTCACATCTTTTTCAGTATCCACAACCATATTGTTTTAAATAGCTTCATGA 
               
               
                   
                   
                 TATGTTTTAATATTTGGTAGAGCTAGAACCCTTTCTTGGTTCTTTTTCTTTTCTTCTTCT 
               
               
                   
                   
                 CCTCCTTTTCCTCCTCCTTCTTTCTCCTCCTCCTTCTTCTTTCTTTTTAGAAATTTCCT 
               
               
                   
                   
                 GGCTATTCTTGTTTTGTAGTCTTCCAGATAAATAATTTTGAATCACTTTGTCATGTTCC 
               
               
                   
                   
                 AGAAAATAATACTGCCAGAATTTTTATTGTGATCACAGAAGTTTTACAGATTCATCTG 
               
               
                   
                   
                 GGGGAAAAAAACCCATCTTCCCAGAATACAGAAAGGGTGAGGGAAAGACAAACATC 
               
               
                   
                   
                 AAGGACAAGTCTCAGGTTCTGGACTTGGAGACCAAGAGGATTTGGGGCATCCGGGA 
               
               
                   
                   
                 GCAGGGCAGGGAGGTGTGATGGCTGCCTTTCACTGAGTAGGAGGATGCCCAGACTT 
               
               
                   
                   
                 GGGGGAACTATGGAAAGTTTGGTTCAGACTTTCTGAGTTGGAGATGTCTATGCGCAG 
               
               
                   
                   
                 TCCACAGGGCGAAGCCCTGGAGGTAGAGGCCCTCCTTACTGCCTCCCTCATTCAGT 
               
               
                   
                   
                 CTGAGGTCCATTCTCCACATGGACACTGAAGTGACTCAAGGCTTCCCTTGTTGGATC 
               
               
                   
                   
                 AGGATAGTCTCCAGGGCCCTGGGTGGTCTGGGCCTGCCCACCTCCCCATCCCCTCT 
               
               
                   
                   
                 CCTGCCTGCCCTCCTCTTGCTCACTGGACCCCACCCACCAGCCTCCTTCTATTCCTC 
               
               
                   
                   
                 CTGACATTTGCACTTGCTGTTCCGTCTCTGCTTGGAACATCCTAGCTCTTTGCATGG 
               
               
                   
                   
                 CTTGCTCCTTCCCATCTTTTAATCTAAGCTCAAATATCACTCCTTCAGATATGCCTTTC 
               
               
                   
                   
                 CCAAATATCCTAGCTAAAGAGAACTGCTCCCCACTTCCCACAAGCCCTAGCAAACTG 
               
               
                   
                   
                 GGACTCTCCTTCTTGCTTTCTTTCTCTCTGCCCCTTCTGTGTTTTTTCCATAGACCTTA 
               
               
                   
                   
                 ACTTGTTACTGTTTTATTTGTTGATGTGTTTACATCATTTGTCCCCCTGTGATGGTTAG 
               
               
                   
                   
                 TTTTATGTGTCAACTTGGCTAGGCTGTAGGGGCTGTTCGTCAATCAAACACTGATCTA 
               
               
                   
                   
                 TGTGTAGCTGTGAAGGGATTTTGTAGCTGTGATTAATAGTTGACTTTAAGTAAGGAAG 
               
               
                   
                   
                 ATTATCCTGGAGAATGTGGGGGAAGGGGCAGACCTCAGCCAATCAGTTGAAAGGCC 
               
               
                   
                   
                 TTAAGAACAAAGCTGAGATTTCCCCGAGGAAGAAGAAATTCTGCCTGTGGACTGCAG 
               
               
                   
                   
                 CATCAGCTCCTGCTTGAGAGGTTCCAGGCTGCCCTTCCTGACAGCCTGTCCTATGAT 
               
               
                   
                   
                 TTTGGACTTGCCTTGCCAGGTTTTTCCTCTTTCTTGACCCCCCAAAACCATATATATC 
               
               
                   
                   
                 TCCTGCTGGTTTGTTTCTCTGGTGTAATCCTGAGGGATGAACACTCCTCCCTCCCAG 
               
               
                   
                   
                 TTCACTCTGGGAGAGGTTGGGGATCATGTTTGTCTATTTCCCCATGCCTGGCCCATG 
               
               
                   
                   
                 CGTGTTTATTGAATCACTGAACAACCACGCATTAGGAAGCCAGTCATATGTGCTTCTT 
               
               
                   
                   
                 CAGAACCTCATGTCCATTGCCAGATCTCCCTGGCTTTTGTGGCTAGAGGACAAGTGA 
               
               
                   
                   
                 GAGATAGTAGCTTACCCACAGACCTTGGCCCTGAGGCCCCCAGGGGCCTGAGCCT 
               
               
                   
                   
                 GCTGTAAGGGAGGAGGGAGCCCCTGAGGTCTCACACACCTCCCTGGGGATCTGGC 
               
               
                   
                   
                 ATTTTCCCCTGGGGCTGGCCTCAGAGCTGGGCGGGGGCAGATTATGGAGTGGGTT 
               
               
                   
                   
                 GTAGAGGGAGCACCTCCCCACTAGCAATCATGGTTTTTTCTGCGCCTCTCATAGGGA 
               
               
                   
                   
                 GGCCTACAGGCCTCCACCTTCAGCTCTTCAGGAGCCACAGGCAGCTGAGTGACTTC 
               
               
                   
                   
                 TGCATCACAGTCTTCTCAGAGACAAACTTGCAGTAAGAAAGAGGGGCCCGTGAGGG 
               
               
                   
                   
                 ACCCCAGAGAAGGCTGTTGTCAAAGCAGGATGAGAGTGAACTCTTCCATGGGGGAC 
               
               
                   
                   
                 ACCCAGCGTCTCCAAGCTCTTTTATGCTGTCTTCAAGGGGTCTAGAGAGCTTCAGCC 
               
               
                   
                   
                 CAACATGAGACCCAGTCCAGCAGCATTTCCCTGCGAAGTGAAAGTTAGGACCCTGA 
               
               
                   
                   
                 CTAGATACACCACGCTGACCTCAGCCAGAATATCAAGATGCTGAGGCGCTGAGATG 
               
               
                   
                   
                 CTGGGATGCTAAGGTGCTAAGGTGCTGGGGTGCTGGGGTGCTAGGATGCTGAGGT 
               
               
                   
                   
                 TTTGTGATACTGGGTCGCTGAGATGCTGGGATACTGGGGTGCTGAAGTGCTGGGGT 
               
               
                   
                   
                 ACTGGGGTGTTGCCATGCTGAAATGCTGGGGTGTTGGGATGCTGAGGTGCTGGGTT 
               
               
                   
                   
                 GCTGGGATGCTGGGATAGTCCTTGGATGCTGCGGTGCTGAGATGCTGGTCTGCTGG 
               
               
                   
                   
                 TCTGCTGGGGTGTTGGGATGCTGGGATTTTGGGATGCTGGAGTGCTGCAGTGCTGC 
               
               
                   
                   
                 AGTGCTGAGATGCTGGAGTGCTGGGGTGCTGGAATACTGTAGTACTGGTGTGCTGG 
               
               
                   
                   
                 AGCATTGAGATGCTAGGGCACTGGGATGCTAAGGTGCTGAGATGCTGCAGTGCTGG 
               
               
                   
                   
                 GGTGTTGGGATGCCGAGGTGTTGGGATGCTTAAGTGCTGGGGTGTTGGGATGCTG 
               
               
                   
                   
                 GGGTGCTGGAACACTATGGTGCTGGGGTGCTGGAGTGTTGAGATACTGTAGTGGTG 
               
               
                   
                   
                 GGATGCTTAAGTGCTGGGGTGCTGGGTGTTGGGATGCCTAGGTGCTGGGGTGCCG 
               
               
                   
                   
                 AGATGCTGGAGTACTAGTGTGCTGGGATGCTGAAGTGCTGGGGTCCTGAGATGCTG 
               
               
                   
                   
                 CAGTGCTAGGGTGCTGAGATTCTGGGCTGCTGGAGTGTTGGGGTGCTGGGATGCT 
               
               
                   
                   
                 GGAGTGCTGAGATGCTTGGACAATGGGGTGCTGGAATACTATGGTGCTGGGGTGCT 
               
               
                   
                   
                 GGGGTATTGAGATGCTAGGGTACTGGGATGCTGAAGTGCTGAGATCCTGGAGTGCT 
               
               
                   
                   
                 GGGCTGCTGGGCCACAGGCTCTTGAATCCATTCGTCTGCCCAGGGGAAGAAACCAG 
               
               
                   
                   
                 AAGATAAAGAGCTAATGAAGGAGCTTTGGTTGAGAGGGAGGAAGTAATGGAAGGAG 
               
               
                   
                   
                 CAACATCTTGTGGAGGAGCAGGAGAGAATGGACCTCAGGTTGGGAGAGAGGGCCA 
               
               
                   
                   
                 GGCTACAGGCCAGAGAGGCAGAAGGATTCCAGCAGAGTGTGGGCTCCAGGAGCCA 
               
               
                   
                   
                 AGGGGAAACAGGTTTCTGGGAGGAGAGAGTCCAGTACTGCTGAAGTGGCAAGTCCG 
               
               
                   
                   
                 CTGAGGACCAGGAAGCTTCATTTGGCTTTATGACCAGGAGGAATTTGGAACTGTGAC 
               
               
                   
                   
                 TAGAGTACTTAGGGGGAAGGAGGCAAGACTGGAGCCAGATTGCTCTGGGTTGAGG 
               
               
                   
                   
                 GGTGAGTGGGAGGTGAAGCAGGGCACTGTCACTCCTTTGAAGGGTGGCAGAGAGC 
               
               
                   
                   
                 TGGAATTGGTGCTGGATGGGCTGTGGGGTGACAGGGTCATGTGGAAAGCCCCTGG 
               
               
                   
                   
                 GGGGCACCTGGAAAAGGAGAAGCTGACAGTACAGTGAGAGGACAGCTAAGGGAAA 
               
               
                   
                   
                 GCGGAATGGCAGAACACGCACTGCCAGGAGGAATGAGGATAGGGTCAGGAGTGCC 
               
               
                   
                   
                 AGGGGCAGTGAGGCCAGCCTGGGGTCAGGTGGCAGGACGTGTCCAGGAAGCTGGT 
               
               
                   
                   
                 CTGCACTGCAGCCCACACTGGCTCAGCCTTGAGGTTCCCTGTGTGGTTGGGGTAGG 
               
               
                   
                   
                 AAGTTGAACCCTCTGGGAATGGAAGATGGAACCAGCTCTGCGAGCCAAGCTCAGCT 
               
               
                   
                   
                 TTTATCTATGGGTCTCTGAGGGCTGGCAGAGCTGAGTGGGGACAACTGTGATCCGT 
               
               
                   
                   
                 GAGGCTCTCAGGTTGAGGTGGCCCCTCCGGGAGGGCTTCATTTTCCCAGCGGGTA 
               
               
                   
                   
                 GGTTCTAAGCAGCAGTGGCTGGGCAGGTGGGTCCAACACAGAGCCAGAGAAGGGT 
               
               
                   
                   
                 GAATGGGCCTCCTGGCACCCCACCCCTGCTGCCCCTGAGCTCAGTGATGGAGGGG 
               
               
                   
                   
                 GACAGCACAGCTGAGCCCAAGTGCTTTGGTGTGGCCCTGAGGGAAAGCTGCAGCCT 
               
               
                   
                   
                 GCCTGGGGCCTGGCATGGATGGGACACTTGAGGCAGAGGGACAATAGTGGGCGCT 
               
               
                   
                   
                 GCAGTGAGGCTGGCTCTTGGAGAGGTTTCCTGAGGAGTGCTGCCTGAGACGGGCA 
               
               
                   
                   
                 GGGAGAACAGAGACAAAGTTGGTGACAGGGAATGAAAGCTGACTGAAGGACTTTAC 
               
               
                   
                   
                 CCAGACCTATGAGGATATCTCTCTCAGCAGGAAGCAGGAGGGGACTGTGTGAGGAC 
               
               
                   
                   
                 TGGCCAAGAGCTGGAGTGTTGGGAAAATGACTCTTTCTCCGACCCCTCTGTCCTAGC 
               
               
                   
                   
                 TCTGGCCCCTGGACTGCGGAGGTCTGCTTCCACCCCCATTGGTCGATCGTTGTCCC 
               
               
                   
                   
                 TTGTCACAGCCATTGAGAATTTTGGCAGGGAGCATGTTCTTAGAGCATTTTTAGGCT 
               
               
                   
                   
                 CTGCGGGACATAACAGCTCTGCCTCAGAGCACATGCCTTTCTCAGCTCCTGAAAGC 
               
               
                   
                   
                 CACTGATCAAATTGGAACATTTTGTACCTTAGGGATGAGGATATCAACTCTCCCAGC 
               
               
                   
                   
                 CACTTAGAGGGATAAATGTGATGATGCATTCAATTGTGACTACATCTGATCCCAACTG 
               
               
                   
                   
                 TTGCTTCAGCTGCTCTCCTATAGCACATGGCGGGAGGCGTGCATCCCAGTAGCTAC 
               
               
                   
                   
                 CTCCCCACTTTTGGGGAGATGTGGTTCCATCCATGAAACCTGGGTACCCGCCTACCA 
               
               
                   
                   
                 GGTCCTGGCCTATCAGGTGGCAGGGTCTGGTCAAAGAAGGGCATGTGTGGTCTTCA 
               
               
                   
                   
                 GCAAGGGAGACAGGACGGTGGTGCAGAGCGTCTAGACCCTCAGGGCAAGTCTCCC 
               
               
                   
                   
                 CCACACCTGCTCCCGGGGCAGTTGTCTTTGTGACCTCCCATCCCCCTCTGTTTCATC 
               
               
                   
                   
                 CTCTATAAAATGAGGGGCTGAGCCCCAAAATAACAGGCTTCTTTGCCATGATGCAAA 
               
               
                   
                   
                 ACTGCTGAATCTTTCTTTCTGACACACAAGGCATCGAGCAGCCTCTGAAAGAACCAA 
               
               
                   
                   
                 AGCCACTAGCAGGCTTCCTGACTTGGGTTTGTAGGTACTGAATACTCCCTTGAAAAA 
               
               
                   
                   
                 TAAAAACATAGAGGCACTTTTCTCCTGGCTGTTTATTACAGAACGAAGAAAAAACACA 
               
               
                   
                   
                 CTGGCTTGAAACAGACGCCAGATTTCAAATGTAGAGGTGAAATACGAGGTGGCAATT 
               
               
                   
                   
                 AAAATGTGATTACAGAAAGTCTGGACACTGAGAAAAGTTTACAGGACAGTGGGTGTG 
               
               
                   
                   
                 GGTTTTCTATAACAGACACTTAAATATACATGACGATAATTGCAGATAGAAACCATCA 
               
               
                   
                   
                 AAGACAAACCCCAAATCAACTAATAATGTTTACAGATGTTCCCCCCCAAACCACAGA 
               
               
                   
                   
                 GCCTTACATCAAAACAAATACTGAAAGGCTTTAAACCAGGAACAGCTCGCCTTAACC 
               
               
                   
                   
                 CCACGAGGGTGCACACAAGCTGGGCTTTTTCTCTCGGTCTGAATGGTAAAGGGAGG 
               
               
                   
                   
                 AGGATACTCTAGCTCCTCCAGGTGGATTGCTGAGACAGGGCTCGGCTCACACACTG 
               
               
                   
                   
                 TCTCTGCGCCTCTCCCAAATCTGGAGAACTCTCCCAGCCTCCTGGTAAAGTGTCTCT 
               
               
                   
                   
                 GTGGGGCACTTAACGATAAAACAGCTTCTGCTGTAAAGCTCATTAGGAAAGAGCTAG 
               
               
                   
                   
                 CCTGCAACCTCCACGGAGTGGGAACTACATCAGGCATTTTGCTAACTGCTGTATCCT 
               
               
                   
                   
                 AGGCCAATAAATGTTGATCACATTTATAGCTGCCATGGTAGGGTGGGGACCCCTGCT 
               
               
                   
                   
                 ATCTATCTGTGGAGGCTCTGGGAGCCCCTGACACAAACTTTCTGAAGCAGAGCCTC 
               
               
                   
                   
                 CCCAACCCCTTTTCCATTCCCTATACCTGACAGATGGCCCAGGAACCCATTAGAAAT 
               
               
                   
                   
                 GGAAGGTCACTGCAGCAGTATGTGAATGTGCGTGTGGGAGAAGGGCAGGATCAGA 
               
               
                   
                   
                 GCCCTGGGGGTGTGGCAGCCCCCAAGTGATTCTAATCCAGATCCTAGGGTTGTTTC 
               
               
                   
                   
                 CCTGTCCCATTGAAATAGCTGCTTTAAGGGGCCTGACTCAGGGAAATCAGTCTCTTG 
               
               
                   
                   
                 AATTAAGTGGTGATTTTGGAGTCATTTAGACCAGGCCTTCAATTGGGATCCACTAGTT 
               
               
                   
                   
                 CTAGAGCGGCCGGGCCCAGGGAACCCCGCAGGCGGGGGCGGCCAGTTTCCCGGG 
               
               
                   
                   
                 TTCGGCTTTACGTCACGCGAGGGCGGCAGGGAGGACGGAATGGCGGGGTTTGGGG 
               
               
                   
                   
                 TGGGTCCCTCCTCGGGGGAGCCCTGGGAAAAGAGGACTGCGTGTGGGAAGAGAAG 
               
               
                   
                   
                 GTGGAAATGGCGTTTTGGTTGACATGTGCCGCCTGCGAGCGTGCTGCGGGGAGGG 
               
               
                   
                   
                 GCCGAGGGCAGATTCGGGAATGATGGCGCGGGGTGGGGGCGTGGGGGCTTTCTC 
               
               
                   
                   
                 GGGAGAGGCCCTTCCCTGGAAGTTTGGGGTGCGATGGTGAGGTTCTCGGGGCACC 
               
               
                   
                   
                 TCTGGAGGGGCCTCGGCACGGAAAGCGACCACCTGGGAGGGCGTGTGGGGACCA 
               
               
                   
                   
                 GGTTTTGCCTTTAGTTTTGCACACACTGTAGTTCATCTTTATGGAGATGCTCATGGCC 
               
               
                   
                   
                 TCATTGAAGCCCCACTACAGCTCTGGTAGCGGTAACCATGCGTATTTGACACACGAA 
               
               
                   
                   
                 GGAACTAGGGAAAAGGCATTAGGTCATTTCAAGCCGAAATTCACATGTGCTAGAATC 
               
               
                   
                   
                 CAGATTCCATGCTGACCGATGCCCCAGGATATAGAAAATGAGAATCTGGTCCTTACC 
               
               
                   
                   
                 TTCAAGAACATTCTTAACCGTAATCAGCCTCTGGTATCTTAGCTCCACCCTCACTGGT 
               
               
                   
                   
                 TTTTTCTTGTTTGTTGAACCGGCCAAGCTGCTGGCCTCCCTCCTCAACCGTTCTGAT 
               
               
                   
                   
                 CATGCTTGCTAAAATAGTCAAAACCCCGGCCAGTTAAATATGCTTTAGCCTGCTTTAT 
               
               
                   
                   
                 TATGATTATTTTTGTTGTTTTGGCAATGACCTGGTTACCTGTTGTTTCTCCCACTAAAA 
               
               
                   
                   
                 CTTTTTAAGGGCAGGAATCACCGCCGTAACTCTAGCACTTAGCACAGTACTTGGCTT 
               
               
                   
                   
                 GTAAGAGGTCCTCGATGATGGTTTGTTGAATGAATACATTAAATAATTAACCACTTGA 
               
               
                   
                   
                 ACCCTAAGAAAGAAGCGATTCTATTTCATATTAGGCATTGTAATGACTTAAGGTAAAG 
               
               
                   
                   
                 AGCAGTGCTATTAACGGAGTCTAACTGGGAATCCAGCTTGTTTGGGCTATTTACTAG 
               
               
                   
                   
                 TTGTGTGGCTGTGGGCAACTTACTTCACCTCTCTGGGCTTAAGTCATTTTATGTATAT 
               
               
                   
                   
                 CTGAGGTGCTGGCTACCTCTTGGAGTTATTGAGAGGATTATAAGACAGTCTATGTGA 
               
               
                   
                   
                 ATCAGCAACCCTTGCATGGCCCCTGGCGGGGAACAGTAATAATAGCCATCATCATGT 
               
               
                   
                   
                 TTACTTACATAGTCCTAATTAGTCTTCAAAACAGCCCTGTAGCAATGGTATGATTATTA 
               
               
                   
                   
                 CCATTTTACAGATGAGGAACCTTTGAAGCCTCAGAGAGGCTAACAGACATACCCTAG 
               
               
                   
                   
                 GTCATACAGTTATTAAGAGAAGGAGCTCTGTCTCGAACCTAGCTCTCTCTCTCTCGA 
               
               
                   
                   
                 GTAATACCAGTTAAAAAATAGGCTACAAATAGGTACTCAAAAAAATGGTAGTGGCTGT 
               
               
                   
                   
                 TGTTTTTATTCAGTTGCTGAGGAAAAAATGTTGATTTTTCATCTCTAAACATCAACTTA 
               
               
                   
                   
                 CTTAATTCTGCCAATTTCTTTTTTTTGAGACAGGGTCTCACTCTGTCACCTAGGATGG 
               
               
                   
                   
                 AGTGCAGTGGCACAATCACTGCTCACTGCAGCCTCGACTTCCCGGGCTCGGGTGAT 
               
               
                   
                   
                 TCTCCCCAGGCTCAGGGGATTCTCCCACTTCAGCCTCCCAAGTAGCTGGGACTACA 
               
               
                   
                   
                 GGTGCGCACCACCATCCCTGGCTAATATTTGTACTTTATTTTATTTATTTATTTATTTA 
               
               
                   
                   
                 TTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCGGGCTGGAGTACAGTGGCATGATCT 
               
               
                   
                   
                 CGGCTCAGTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTACCTCATCCCCCT 
               
               
                   
                   
                 GAGTAGCTGGGATTACAGGCGCCTGCCACCATGCCTGGCTAATTTTTTGTATTTTTA 
               
               
                   
                   
                 ATAGAGACGAGGTTTCACCATGTTGGCCAGGCTACTCTCGAACTCCTGATCTCAGGT 
               
               
                   
                   
                 GATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGC 
               
               
                   
                   
                 CCGGCCTAATATTTGTATTTTTTGTAGAGATGGTGTTTTGCCATGTTGTCCAGGCTGG 
               
               
                   
                   
                 TCTTGAACTCCTGAGCTCAAGCGATCTGCCCGCCTCTGCTTCCCAAAGTGCTGGGAT 
               
               
                   
                   
                 TACAGGCATGAGCCACCGTGCCTGGCCTAGGTAGACGCTTTTAGCTTTGGGGTGTG 
               
               
                   
                   
                 ATGCCTGCCCCAGTATATAGTGAATTTAATTATTGCTAGAGCTGGCTGTTTGTTAGTT 
               
               
                   
                   
                 TTCTTTGAACATAAGATACTCATTGTTTTTAGTTTGCAAATCCCTCTTCCTTTTTAAAAA 
               
               
                   
                   
                 ATTTCTTTCCCTTAAATTGTTTGCATGTTAGCAATAACAAATGCTTAAATGGTGCTATG 
               
               
                   
                   
                 TGCTAGATACTCTTCTAAGCCCTGTTATGTATATTAACTAATTTTTTAAATTACACAAAT 
               
               
                   
                   
                 CAGAGAGGTTAAGTAACTTGCCCAAGATTACCCAACAATACTAGGATTTGAACCTAA 
               
               
                   
                   
                 GTTTGTCTCACCCCAGATTCTGCTCTTAATCTCTAAACTTTTAAGTTAGTAGTGACAAT 
               
               
                   
                   
                 AGTAGGTATTTATTGAATACTTAACTATGTTTTAGGCGTTGAAGTAAATATTTTGCAGG 
               
               
                   
                   
                 CATTATCTAATGTAAACACCCTAAAGTTACATAACAGGTACCCTTTAGGTAAATAAAC 
               
               
                   
                   
                 ACTAGTATGACCTTGGAGGCACAGATAGTTGAAGTAACTTGCCCAATATCACTTACAT 
               
               
                   
                   
                 GAAATTGGCCCTCAAATGTGTCTGATACAACCCATGCTGCTTGTAACTATCGTTTTAA 
               
               
                   
                   
                 ACTGCCAGGGTAAACTTGGACACACTTGAGCTAAGAAAAAGCTTTTAGATTTTTGCAA 
               
               
                   
                   
                 ATTAATGTGAAAGATATGCTTTATGTGGATATAATATCTTCTAAATTTCGGGGATGGTA 
               
               
                   
                   
                 GTCCTAGAAATGTAATCCTGCCCTAGCCGAGCTTACCCTGCCAATAATTTTTTACAGA 
               
               
                   
                   
                 ATTGGTAAAACGGAGCACCTTTTTTTTGTCCTTGGCCACACTGTTATCAACAGGGTGT 
               
               
                   
                   
                 AGATTGACATCAATCTGTAGGTGTAAACCAGAATTACTCTTTGTGACCACCAGGAAAT 
               
               
                   
                   
                 AGAGCAGTTCAGTTCAGGGGTTTCTTTCTGTGAATTTAGCACTGTGACCTGCATACTA 
               
               
                   
                   
                 CAAGTCTACTTTGTTTTCTATCCATTGTTTGTATCTGGGTATTGCAAAAGGTAGGAAA 
               
               
                   
                   
                 AGGACCAACCAGATCAGCAGAGAAGAGTTGCCTTGGAGTTTTCTTTTAGTTTTCTGC 
               
               
                   
                   
                 AGTTCATTAGATAGTAACTAGGCCATGTCATTTTACTCCCTTGTAGTGAAGATATGTT 
               
               
                   
                   
                 GAAGTTGTACTGGTATACTCTTCTACCTTTCTGTAATTTTATATTGTGTAGACTTGATA 
               
               
                   
                   
                 AAATTTATGTGTCAATCACCACCATTAATATCAATATTGAGCCTCAATTCTTATTTTTCT 
               
               
                   
                   
                 GCCCAGTGGCTGCCAAATTACTAACATTTACAATAATTCACTACTACTAAGATAATCT 
               
               
                   
                   
                 ACTAGTTCGATCACATACTTCAAATTGTTATGGAACTACTGTCTTCAGCATTGTGCTT 
               
               
                   
                   
                 CTGATAACTGATAAGTATAATTTTTTTTTTGTCCAGAGTGAACATGTCTATTCTTCCAC 
               
               
                   
                   
                 TGTACACACTAATAAAAGGAAAAATTGTAATATTGGGTAAATTCATGTCCTTACACAT 
               
               
                   
                   
                 GTAGTAGTTATGAGCCCATGTCCCTAGAATGAGTAATAATTTATCCCTCCCTTGGTTG 
               
               
                   
                   
                 AATAGTCAAGAATGCTGATTTTAATTCTTCTAACAGCTTTATCCCTCAGAAGGGAAGG 
               
               
                   
                   
                 CAAGCAAGTTATATATGTAGTTTATTTGTAAGACTGATATGAAATTGGAAGATGAATCT 
               
               
                   
                   
                 ACTATTAGCTTTAATTATTTTTACATTTAGGAATATTGCATCAGTAACTCATAATTTTGG 
               
               
                   
                   
                 TTTTCTGTTATCCTGAGTTAACACAAATTATCCAAGGAGATGGCGGATCATCTGCTTT 
               
               
                   
                   
                 GAGGTGTTTTTTTTTGAGAATTTTAATGTATCTGAATATAAAAGGTAAAAATATGCCAA 
               
               
                   
                   
                 CTAGCAATTTCTGCCCATTCCAGAAGTTTGGAAATATTACTCATTACTAGGAATTAAAT 
               
               
                   
                   
                 AAAATATGGTTTATCTATTGTTATACCTCTTTTAATTCACATAGCTCATTTTTATCTTTT 
               
               
                   
                   
                 ATTTTTGTTTGTTTTTTTTGAGATGGAGTCTTGCTCTGTCACCAGGCAGGAGTGCAGT 
               
               
                   
                   
                 GATGCAAATCTCGGCTCACTCTAGCCACCGACTCCCTGGTTCAAGCGATTCTCCTGC 
               
               
                   
                   
                 CTGAGCCTTCTGAGTAGCTGGGATTACAGGCAGGCACCACCACGCCCAGCTAATTT 
               
               
                   
                   
                 TTGTAGAGACAGGATTTCACCGTGTTGGCCAGGATGGTCTCCATCTCCTGACCTCAT 
               
               
                   
                   
                 GATCTGCCTGCTTCGGCCTCCCAAAGTGCTGGGATTACAGGTGGGAGCCACTACGC 
               
               
                   
                   
                 CTGGCCCACATAGCTCATTTTTAGACTCACTTCCATTAAGTCTTGTTTGGACCCACGA 
               
               
                   
                   
                 ACATTGTCTTTTTTTTTTTAAGATGGAGTTTCACTTTTGTTGCCCAGACTGTAGTGCAA 
               
               
                   
                   
                 TGGTGCAATCTCAGCTCACTGCAATCTCTGCCTCCTGGGTTCTAGCAATTCTCCTGC 
               
               
                   
                   
                 CTCAGCCTCCCGAGTAGCTGGAATTACAGGCGCCCGCCACCACGCCCAGCTAATTT 
               
               
                   
                   
                 TTGTGTTTTTAGTAGAGACGGGGTTTCACCATGTTGGGCAGGCCAGGGGTGATCCG 
               
               
                   
                   
                 CCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCATCTGGCC 
               
               
                   
                   
                 AACATGTCTTTTTTTTTTTTTTCCTTTTTAACCACAAAGAGACTTAAGCAGTCCTTGTC 
               
               
                   
                   
                 ACAGATGATGAATTGATGTTGCAAGTATTGTCTTAGCTTGGATTAATTTTCTTGCTTAC 
               
               
                   
                   
                 TGTAATTTTAGATAATATAGCTTTGTAATTAGAGATTTTATGTGTAAACCACAAAAATG 
               
               
                   
                   
                 TTTACATGAAGGCCATTATTACAGATGTGACGTGCATAATTATTAGTAATTTGTATGTT 
               
               
                   
                   
                 TACATGGGTCAGTCTGGCAAAAAATTATGAAGTTTTAAAAATTAAAAAAAATTATAATG 
               
               
                   
                   
                 CCAGTTTTACTGGAAAGTAAAATTATTTCAGTAATCGATTATAGCAAAAGTATTGATTT 
               
               
                   
                   
                 TCATTCCAGACAACTGTCTGTCTATAGCCAATTATGCATTTCTTAAATTAGAACCCCC 
               
               
                   
                   
                 CCAATATACCCAAATATATATATATGTGTGCATATATATAGTAAGTTGTAACAAAGTTG 
               
               
                   
                   
                 TGAATTCATACCTGAAGTATCTCAAGTGATGCAAGTTTTATGAATTTTTGTTTATGCCT 
               
               
                   
                   
                 TTTGGGAAGAGTTGTATTGACAAATTTTTTATGCTTAAAGTAAACCATAAATCAAAAAA 
               
               
                   
                   
                 ATAAAATCTAGGATGCAATAAAACAAAACAACTTCTTGACATAAGTATGGTATGTAAAT 
               
               
                   
                   
                 CTGTTTTGATTGGAAATCAATTTGTTATATTGCCAGAATTCCTGTTTTAGAATACATCT 
               
               
                   
                   
                 CTGCTGATCTGTCTGTATTCTTAGACTGCATATCTGGGATGAACTCTGGGCAGAATT 
               
               
                   
                   
                 CACATGGGCTTCCTTTGAAATAAACAAGACTTTTCAAATTCTTAGTCGATCTGCAGAA 
               
               
                   
                   
                 CCTGTAGCCAGGCACTGAACCATTTTGATAGATGCAGTAATCGTTGCAAGTGTATATT 
               
               
                   
                   
                 TCAAGGGAGTTCTGGCTGGGTCCTAGTTTATGCTTGTGGCAGAAGCAGTGAGTAACT 
               
               
                   
                   
                 GGGAGGAAGTTGGTGAGTAAGCTTCAAGGAAGAAGTCATTTTTAGTACTCTGGATCT 
               
               
                   
                   
                 TCCTGATTTTAAAGCACTACAAAATGGTGCATTTTCATTCTTGTCAAGTGATAACAGAT 
               
               
                   
                   
                 ATATTCTGATGAGCCTGAAATGAATATATATTGTATCATTTTTATAATATCTAGCAAGG 
               
               
                   
                   
                 TTTGTATTTTCCTAGAACTTGAACTAAATTTCAGTTCATAAAATTTATAAAATACTTAGT 
               
               
                   
                   
                 TGTTGTAAAATATTTTTGGAATGTTCACATAGGTGACACACAAATGTCCCATTTTCATT 
               
               
                   
                   
                 CTTTCTATAGTAAATATGTTCTGATATGTGAAGGTTTAGCAGATGCATCAGCATTTAAT 
               
               
                   
                   
                 CCTAGAGGATCTGGCATAATCTTTTCCCCCAAGAATAGAAATTTTTTCTGCTTATGAA 
               
               
                   
                   
                 AGTAGTACATGTTTCTTTAAAAACAAATCAATATTGACTTCTGCCTGCTGTATAGCACT 
               
               
                   
                   
                 ATGCCTCCACCTGGCCATGACCAGGGGCATGTCCTGGTCCACCTACCTGAAAATGT 
               
               
                   
                   
                 TTGCAACCAGCCTCCTGGCCATGTGCACAGGGGCTGAAGTTGTCCCACAGGTATTA 
               
               
                   
                   
                 CGGGCCAACCTGACAATACATGAAGTTCCACCAAAGTCTGAGAACTCAGAACTGAGC 
               
               
                   
                   
                 TTTGGGGACTGAAAGACAGCACAAACCTCAAATTTCTCAGCACTGGAAACCTCAAAA 
               
               
                   
                   
                 TATAACTGAATTCCATAAATAAGATTTTAAGTCTTAAATATGTATTTTTAAATGTATTAA 
               
               
                   
                   
                 AAGTCAAGCTGCTTGTATTTAAGCACCTAATACAATGCTTAGGTTGTAAAAGGAGATG 
               
               
                   
                   
                 CTCAATAGGTACTAACTGATATATTGAGATTTAATTATGGTTTGACCAATATTTATTGG 
               
               
                   
                   
                 AAACCGCCAAAGCTTAAATCATCAGCTTCTTGAATGTGATTTGAAAGGTAATTTAGTA 
               
               
                   
                   
                 TTGAATAGCATGTGAGCTAGAGTATTTCATTCTTTCTGGTTTATTTCTTCAAATAGACT 
               
               
                   
                   
                 TTGAATATAATGGTGAATGGGTATTATAAATTAACTAATAAAAATGACATTGAAAATGA 
               
               
                   
                   
                 AAAAATATATATATTAAAGTGTAGAAAGTGACCAGGCGTGGTGGCTCACACCTGTAAT 
               
               
                   
                   
                 CCAAGCACCTTGGGAGGCTGAGGCAGGAGGATCTCTTGATCCCAGGAGTTCAAGAC 
               
               
                   
                   
                 CAGCCTGGGCAACATAGCGAGACTTCGTCTCTAAAAAAAAAAAAGAGAGAGAAAAAA 
               
               
                   
                   
                 ATTTTTTTTATTTAAAAAAAGTGTAGAAAGTGTCAAGACCCCACTTCTTACCATTATTT 
               
               
                   
                   
                 GGTATATTTCTCTATACCCACCCACCCTTCCTCCTTACTCCCTCCCTCCCTTCCCAAT 
               
               
                   
                   
                 CTTTTTATCTTTTTGTATTCTGATTTTTTGTTTGTATATTTTGCTTTAATTTAATGTATCC 
               
               
                   
                   
                 TTTAAAAATTTCCCATACATTTTATATGTATATATAAAAACGCATGCTGCCAAAGATAA 
               
               
                   
                   
                 TTTATAAGAAAGACCATTGAATTTTTTTAAAAGTGATATATATTCATTGAAAAAAATTTA 
               
               
                   
                   
                 GAATATATAGCAAAGCAATAAAGAACTAAATAAAATTGCTGTAACTCCTCTTTCAAAG 
               
               
                   
                   
                 ATAAGTGCTTTTATGATTTTGTTGTATTTTTTTCTGTATATAGGTACATATATAGTATTT 
               
               
                   
                   
                 ATAAAGCTGTACTCATAGTACATTTTCACATCACAGGTACCATATCAGTGTTATTAAAT 
               
               
                   
                   
                 ATTTTGTATGCCAGGGGCTAGACATACCAAGACAACCAATATGTGGTTCTACTTAAAT 
               
               
                   
                   
                 AATATTAGAGTATCTTTTATGATGACACTTCATGAGTTGACTATAATAATCTTAGACTT 
               
               
                   
                   
                 CTAAGAGTTTGGGTTTTCAAAAGATCACTTAGCTTTTTTGGGTGATTTTTCCCCCTTA 
               
               
                   
                   
                 CTGTGAGATGAGAGAGGCTGTTTGGATTTGGGATTGGGGTAGCGGGGACAGCAACT 
               
               
                   
                   
                 TTTCTTTTCTTTTTCTTTTTTATTTTGAGGTAGGGTATTGCTGTGTCACCCAGGCTGGA 
               
               
                   
                   
                 GTGCAGTGGTGTGATCTCGGCTCACTGCAACCTCCACCTCCCGGGCTCAGGTGATC 
               
               
                   
                   
                 CTCCTGCTTCAGCCTCCCAGTAACTGGGACTACAGGCGCGTGCCACATGCCTGGCT 
               
               
                   
                   
                 AATTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCTAAC 
               
               
                   
                   
                 TCCTGACCTCAGGTGATACGCCCACCTGGGCCTCCCAAAATACTGGGATTACAGGC 
               
               
                   
                   
                 ATGAGCCGCTGCATCAGCCAGCAGTTTTTCTTGTGGTTTTTTTTGTTTGTTTTGTTTTG 
               
               
                   
                   
                 TTTTGTTTTTGAGATAGGGTCTTACTCTGTTGTCCACGCTGGAGTGCTGTGGTATGAT 
               
               
                   
                   
                 CGTAGCTCACTGCAGCCTCAAACTCCTGGGCTCAAGTGATTCCTTCTGCCTCCGCCT 
               
               
                   
                   
                 CCCGAGTAGCTGGGACTACAGGTATGCACCACCATACCTGGCAAATTTTTACAAAGT 
               
               
                   
                   
                 TTTTTGTAGGGACGGGGTCTTGCTACATTCCCCATGTCGGTCTTGAACTCCTGGCCT 
               
               
                   
                   
                 CAAGCAACTCTCCTGTCTCAGCCTCCCAAAGCACTGGGATTACAAGTGTGAGCCACC 
               
               
                   
                   
                 ACACCATGCCAGTTTTTCCTGTTCAGTGTGATATTTTATCTTGTTAGACTACAGTGTG 
               
               
                   
                   
                 TTAAAACTTGTTTTACTAAATTTTCAAACATACTCAAAAGTGGAGAGAATAGTATAATG 
               
               
                   
                   
                 AATACCCGTATGTTCATCACCCATGTTTAGAATATTATTAAATATAAAGATTTTGCTGC 
               
               
                   
                   
                 GTTTGTCTTAGCTCTTTAAAATTTTTCTTTTTCTCTTTGTGACCTAAAGGAAATTCCATA 
               
               
                   
                   
                 TCTTATCACTTTACTTCTACATTCTTGACTAAGATGACTAAGACATATAGTTACATGGT 
               
               
                   
                   
                 TTTTTGTTTTGTTTTTGTTTTTTAAAGACGAAATCTCGCTCTTGTCCCCCAGGCTGGA 
               
               
                   
                   
                 GTGCAATGGTGCCATCTCAGCTCAGTGCAACCTCTGCCTTCTGGGTACAAGCGATTC 
               
               
                   
                   
                 TCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCTCCTGCCACCACGCCTGGC 
               
               
                   
                   
                 TAATTTTTGTATTTTTAGTAGAGACGGCGGGGGGAGGTTTCACCATGTTGACAAGGC 
               
               
                   
                   
                 TGGTCTGGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTG 
               
               
                   
                   
                 GGATTACAGGCGTGAGCCACCGCGCCCAGCCTGTTTTTTTGTTTGTGTGTTTTGTTT 
               
               
                   
                   
                 TTTTTGAGACAGAGTCTTGCTCTGTTTCCCAGGCTGGAGTGAAGTGGTGCCATCTCA 
               
               
                   
                   
                 GCTCAGAGACAGAGTCTTGCTCTGTTTCCCAGGCTGGAGTGAAGTGGTGCCATCTT 
               
               
                   
                   
                 GGCTCACTGCAACCTTCACCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCA 
               
               
                   
                   
                 AGTAGCTGGGACTACAGGCATGTGTCACCACACCCGGCTAATTTTTTTGTATTTTTAG 
               
               
                   
                   
                 TAGAGACGGGATTTCACCGTGTTGCCCAGGCTGGTCTCGAACTCCTGAGCTCAGGC 
               
               
                   
                   
                 AGTCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGTGTGAACCAACCCGC 
               
               
                   
                   
                 CCGGCCTGTTGTTTTCTTACATAATTCATTATCATACCTACAAAGTTAACAGTTACTAA 
               
               
                   
                   
                 TATCATCTTACACCTAAATTTCTCTGATAGACTAAGGTTATTTTTTAACATCTTAATCCA 
               
               
                   
                   
                 ATCAAATGTTTGTATCCTGTAATGCTCTCATTGAAACAGCTATATTTCTTTTTCAGATT 
               
               
                   
                   
                 AGTGATGATGAACCAGGTTATGACCTTGATTTATTTTGCATACCTAATCATTATGCTG 
               
               
                   
                   
                 AGGATTTGGAAAGGGTGTTTATTCCTCATGGACTAATTATGGACAGGTAAGTAAGAT 
               
               
                   
                   
                 CTTAAAATGAGGTTTTTTACTTTTTCTTGTGTTAATTTCAAACATCAGCAGCTGTTCTG 
               
               
                   
                   
                 AGTACTTGCTATTTGAACATAAACTAGGCCAACTTATTAAATAACTGATGCTTTCTAAA 
               
               
                   
                   
                 ATCTTCTTTATTAAAAATAAAAGAGGAGGGCCTTACTAATTACTTAGTATCAGTTGTG 
               
               
                   
                   
                 GTATAGTGGGACTCTGTAGGGACCAGAACAAAGTAAACATTGAAGGGAGATGGAAG 
               
               
                   
                   
                 AAGGAACTCTAGCCAGAGTCTTGCATTTCTCAGTCCTAAACAGGGTAATGGACTGGG 
               
               
                   
                   
                 GCTGAATCACATGAAGGCAAGGTCAGATTTTTATTATTATGCACATCTAGCTTGAAAA 
               
               
                   
                   
                 TTTTCTGTTAAGTCAATTACAGTGAAAAACCTTACCTGGTATTGAATGCTTGCATTGTA 
               
               
                   
                   
                 TGTCTGGCTATTCTGTGTTTTTATTTTAAAATTATAATATCAAAATATTTGTGTTATAAA 
               
               
                   
                   
                 ATATTCTAACTATGGAGGCCATAAACAAGAAGACTAAAGTTCTCTCCTTTCAGCCTTC 
               
               
                   
                   
                 TGTACACATTTCTTCTCAAGCACTGGCCTATGCATGTATACTATATGCAAAAGTACAT 
               
               
                   
                   
                 ATATACATTTATATTTTAACGTATGAGTATAGTTTTAAATGTTATTGGACACTTTTAATA 
               
               
                   
                   
                 TTAGTGTGTCTAGAGCTATCTAATATATTTTAAAGGTTGCATAGCATTCTGTCTTATGG 
               
               
                   
                   
                 AGATACCATAACTGATTTAACCAGTCCACTATTGATAGACACTATTTTGTTCTTACCGA 
               
               
                   
                   
                 CTGTACTAGAAGAAACATTCTTTTACATGTTTGGTACTTGTTCAGCTTTATTCAAGTGG 
               
               
                   
                   
                 AATTTCTGGGTCAAGGGGAAAGAGTTTATTGAATATTTTGGTATTGCCAAATTTTCCT 
               
               
                   
                   
                 CTAAGAAGTTGAATCATTTTATACTCCTGATGTTATATGAGAGTACCTTTCTCTTCACA 
               
               
                   
                   
                 ATTTGTCTCTTTTTTTTTTTTTTTTGAGACAAGGTCTCTGTTGCCCAGGCTGGGGTGC 
               
               
                   
                   
                 AGTGCAGCAGAATGATCACAGTTCACTGCAGTCTCAACCTCCTGGGTTCAAGCGATC 
               
               
                   
                   
                 CTTCCACCTCAGCCTCCTGAGTAGCTGGGACTATAGGTGTGCGCCACCACTCCCAG 
               
               
                   
                   
                 CTAATATTTTTATTTTGTAGAAACAGGGTTCGCCATGTTACCCAGCCTCCCAAAGTGC 
               
               
                   
                   
                 TGGGATTACAGGCATGAGCCACTGGCCCAGTTTCTACAGTCTCTCTTAATATTGTATA 
               
               
                   
                   
                 TTATCCAGAAAATTTCATTTAATCAGAACCTGCCAGTCTGATAGGTGAAAATGGTATC 
               
               
                   
                   
                 TTGTTTTTATTTGCATTTAAAAAAAATTATGATAGTGGTATGCTTGGTTTTTTTGAAGG 
               
               
                   
                   
                 TATCAAATTTTTTACCTTATGAAACATGAGGGCAAAGGATGTGATACGTGGAAGATTT 
               
               
                   
                   
                 AAAAAAAATTTTTAATGCATTTTTTTGAGACAAGGTCTTGCTCTATTGTCCAGGCTGG 
               
               
                   
                   
                 AGTGCAGTGGCACAATCACAGTTCACTCCAGCCTCAACATCCTGCACTAAAGTGATT 
               
               
                   
                   
                 TTCCCACCTCACCTCTCAAGTAGCTGGGACTACAGGTACATGCTACCATGCCTGGCT 
               
               
                   
                   
                 AATTTTTTTTTTTTTGCAGGCATGGGGTCTCACTATATTGCCCAGGTTGGTGTGGAAG 
               
               
                   
                   
                 TTTAATGACTAAGAGGTGTTTGTTATAAAGTTTAATGTATGAAACTTTCTATTAAATTC 
               
               
                   
                   
                 CTGATTTTATTTCTGTAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGG 
               
               
                   
                   
                 AGGCCATCACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGA 
               
               
                   
                   
                 CCTGCTGGATTACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACT 
               
               
                   
                   
                 GTAGATTTTATCAGACTGAAGAGCTATTGTGTGAGTATATTTAATATATGATTCTTTTT 
               
               
                   
                   
                 AGTGGCAACAGTAGGTTTTCTTATATTTTCTTTGAATCTCTGCAAACCATACTTGCTTT 
               
               
                   
                   
                 CATTTCACTTGGTTACAGTGAGATTTTTCTAACATATTCACTAGTACTTTACATCAAAG 
               
               
                   
                   
                 CCAATACTGTTTTTTTAAAACTAGTCACCTTGGAGGATATATACTTATTTTACAGGTGT 
               
               
                   
                   
                 GTGTGGTTTTTTAAATAAACTCCTTTTAGGAATTGCTGTTGGGACTTGGGATACTTTTT 
               
               
                   
                   
                 TCACTATACATACTGGTGACAGATACCCTCTCTTGAGCTACATCGGTTTGTGGGGAG 
               
               
                   
                   
                 TCAAAAGTCCTTTGGAGCTAGGTTTGACAAATAAGGTGGGTTAACACTTGTTTCCTAG 
               
               
                   
                   
                 AAAGCACATGGAGAGCTAGAGTATTGGCGAATTGAAGAAATCCCCCTTTTTTTTTAAC 
               
               
                   
                   
                 ACACTTAAGAAAGGGGACTGCAGGTATACTCAAGAGAGTAAGTCGCACCAGAAACC 
               
               
                   
                   
                 ACTTTTGATCCACAGTCTGCCTGTGTCACACAATTGAAATGCATCACAACATTGACAC 
               
               
                   
                   
                 TGTGGATGAAACAAAATCAGTGTGAATTTTAGTAGTGAATTTCATTCATAATTTGATCG 
               
               
                   
                   
                 TGCAAACGTTTGATTTTTATTACTTTAGACTATTGTTTCTGATTTTATGTTGGGTTGGT 
               
               
                   
                   
                 ATTTCCTGTGAGTTACTGTTTTACCTTTAAAATAGGAATTTTTCATACTCTTCAAAGAT 
               
               
                   
                   
                 TAGAACAAATGTCCAGTTTTTGCTGTTTCATGAATGAGTCCTGTCCATCTTTGTAGAA 
               
               
                   
                   
                 ACTCGCCTTATGTTCACATTTTTATTGAGAATAAGACCACTTATCTACATTTAACTATC 
               
               
                   
                   
                 AACCTCATCCTCTCCATTAATCATCTATTTTAGTGACCCAAGTTTTTGACCTTTTCCAT 
               
               
                   
                   
                 GTTTACATCAATCCTGTAGGTGATTGGGCAGCCATTTAAGTATTATTATAGACATTTT 
               
               
                   
                   
                 CACTATCCCATTAAAACCCTTTATGCCCATACATCATAACACTACTTCCTACCCATAA 
               
               
                   
                   
                 GCTCCTTTTAACTTGTTAAAGTCTTGCTTGAATTAAAGACTTGTTTACGGTATCGATAA 
               
               
                   
                   
                 GCTTGATATCAAAACGCCAACTTTGACCCGGAACGCGGAAAACACCTGAGAAAAACA 
               
               
                   
                   
                 CCTGGGCGAGTCTCCACGTAAACGGTCAAAGTCCCCGCGGCCCTAGACAAATATTA 
               
               
                   
                   
                 CGCGCTATGAGTAACACAAAATTATTCAGATTTCACTTCCTCTTATTCAGTTTTCCCG 
               
               
                   
                   
                 CGAAAATGGCCAAATCTTACTCGGTTACGCCCAAATTTACTACAACATCCGCCTAAAA 
               
               
                   
                   
                 CCGCGCGAAAATTGTCACTTCCTGTGTACACCGGCGCACACCAAAAACGTCACTTTT 
               
               
                   
                   
                 GCCACATCCGTCGCTTACATGTGTTCCGCCACACTTGCAACATCACACTTCCGCCAC 
               
               
                   
                   
                 ACTACTACGTCACCCGCCCCGTTCCCACGCCCCGCGCCACGTCACAAACTCCACCC 
               
               
                   
                   
                 CCTCATTATCATATTGGCTTCAATCCAAAATAAGGTATATTATTGATGATGTTT 
               
               
                   
               
               
                 126 
                 Ad5/3Ad2E1AΔ24 
                 TAACATCATCAATAATATACCTTATTTTGGATTGAAGCCAATATGATAATGAGGGGGT 
               
               
                   
                   
                 GGAGTTTGTGACGTGGCGCGGGGCGTGGGAACGGGGCGGGTGACGTAGTAGTGT 
               
               
                   
                   
                 GGCGGAAGTGTGATGTTGCAAGTGTGGCGGAACACATGTAAGCGACGGATGTGGCA 
               
               
                   
                   
                 AAAGTGACGTTTTTGGTGTGCGCCGGTGTACACAGGAAGTGACAATTTTCGCGCGG 
               
               
                   
                   
                 TTTTAGGCGGATGTTGTAGTAAATTTGGGCGTAACCGAGTAAGATTTGGCCATTTTC 
               
               
                   
                   
                 GCGGGAAAACTGAATAAGAGGAAGTGAAATCTGAATAATTTTGTGTTACTCATAGCG 
               
               
                   
                   
                 CGTAATATTTGTCTAGGGCCGCGGGGACTTTGACCGTTTACGTGGAGACTCGCCCA 
               
               
                   
                   
                 GGTGTTTTTCTCAGGTGTTTTCCGCGTTCCGGGTCAAAGTTGGCGTTTTATTATTATA 
               
               
                   
                   
                 GTCAGCTGACGTGTAGTGTATTTATACCCGGTGAGTTCCTCAAGAGGCCACTCTTGA 
               
               
                   
                   
                 GTGCCAGCGAGTAGAGTTTTCTCCTCCGAGCCGCTCCGACACCGGGACTGAAAATG 
               
               
                   
                   
                 AGACATATTATCTGCCACGGAGGTGTTATTACCGAAGAAATGGCCGCCAGTCTTTTG 
               
               
                   
                   
                 GACCAGCTGATCGAAGAGGTACTGGCTGATAATCTTCCACCTCCTAGCCATTTTGAA 
               
               
                   
                   
                 CCACCTACCCTTCACGAACTGTATGATTTAGACGTGACGGCCCCCGAAGATCCCAAC 
               
               
                   
                   
                 GAGGAGGCGGTTTCGCAGATTTTTCCCGAGTCTGTAATGTTGGCGGTGCAGGAAGG 
               
               
                   
                   
                 GATTGACTTATTCACTTTTCCGCCGGCGCCCGGTTCTCCGGAGCCGCCTCACCTTTC 
               
               
                   
                   
                 CCGGCAGCCCGAGCAGCCGGAGCAGAGAGCCTTGGGTCCGGTTTCTATGCCAAAC 
               
               
                   
                   
                 CTTGTGCCGGAGGTGATCGATCCACCCAGTGACGACGAGGATGAAGAGGGTGAGG 
               
               
                   
                   
                 AGTTTGTGTTAGATTATGTGGAGCACCCCGGGCACGGTTGCAGGTCTTGTCATTATC 
               
               
                   
                   
                 ACCGGAGGAATACGGGGGACCCAGATATTATGTGTTCGCTTTGCTATATGAGGACCT 
               
               
                   
                   
                 GTGGCATGTTTGTCTACAGTAAGTGAAAATTATGGGCAGTCGGTGATAGAGTGGTGG 
               
               
                   
                   
                 GTTTGGTGTGGTAATTTTTTTTTAATTTTTACAGTTTTGTGGTTTAAAGAATTTTGTATT 
               
               
                   
                   
                 GTGATTTTTTAAAAGGTCCTGTGTCTGAACCTGAGCCTGAGCCCGAGCCAGAACCG 
               
               
                   
                   
                 GAGCCTGCAAGACCTACCCGGCGTCCTAAATTGGTGCCTGCTATCCTGAGACGCCC 
               
               
                   
                   
                 GACATCACCTGTGTCTAGAGAATGCAATAGTAGTACGGATAGCTGTGACTCCGGTCC 
               
               
                   
                   
                 TTCTAACACACCTCCTGAGATACACCCGGTGGTCCCGCTGTGCCCCATTAAACCAGT 
               
               
                   
                   
                 TGCCGTGAGAGTTGGTGGGCGTCGCCAGGCTGTGGAATGTATCGAGGACTTGCTTA 
               
               
                   
                   
                 ACGAGTCTGGGCAACCTTTGGACTTGAGCTGTAAACGCCCCAGGCCATAAGGTGTA 
               
               
                   
                   
                 AACCTGTGATTGCGTGTGTGGTTAACGCCTTTGTTTGCTGAATGAGTTGATGTAAGTT 
               
               
                   
                   
                 TAATAAAGGGTGAGATAATGTTTAACTTGCATGGCGTGTTAAATGGGGCGGGGCTTA 
               
               
                   
                   
                 AAGGGTATATAATGCGCCGTGGGCTAATCTTGGTTACATCTGACCTCATGGAGGCTT 
               
               
                   
                   
                 GGGAGTGTTTGGAAGATTTTTCTGCTGTGCGTAACTTGCTGGAACAGAGCTCTAACA 
               
               
                   
                   
                 GTACCTCTTGGTTTTGGAGGTTTCTGTGGGGCTCATCCCAGGCAAAGTTAGTCTGCA 
               
               
                   
                   
                 GAATTAAGGAGGATTACAAGTGGGAATTTGAAGAGCTTTTGAAATCCTGTGGTGAGC 
               
               
                   
                   
                 TGTTTGATTCTTTGAATCTGGGTCACCAGGCGCTTTTCCAAGAGAAGGTCATCAAGA 
               
               
                   
                   
                 CTTTGGATTTTTCCACACCGGGGCGCGCTGCGGCTGCTGTTGCTTTTTTGAGTTTTA 
               
               
                   
                   
                 TAAAGGATAAATGGAGCGAAGAAACCCATCTGAGCGGGGGGTACCTGCTGGATTTT 
               
               
                   
                   
                 CTGGCCATGCATCTGTGGAGAGCGGTTGTGAGACACAAGAATCGCCTGCTACTGTT 
               
               
                   
                   
                 GTCTTCCGTCCGCCCGGCGATAATACCGACGGAGGAGCAGCAGCAGCAGCAGGAG 
               
               
                   
                   
                 GAAGCCAGGCGGCGGCGGCAGGAGCAGAGCCCATGGAACCCGAGAGCCGGCCTG 
               
               
                   
                   
                 GACCCTCGGGAATGAATGTTGTTCAGGTGGCTGAACTGTATCCAGAACTGAGACGC 
               
               
                   
                   
                 ATTTTGACAATTACAGAGGATGGGCAGGGGCTAAAGGGGGTAAAGAGGGAGCGGG 
               
               
                   
                   
                 GGGCTTGTGAGGCTACAGAGGAGGCTAGGAATCTAGCTTTTAGCTTAATGACCAGA 
               
               
                   
                   
                 CACCGTCCTGAGTGTATTACTTTTCAACAGATCAAGGATAATTGCGCTAATGAGCTTG 
               
               
                   
                   
                 ATCTGCTGGCGCAGAAGTATTCCATAGAGCAGCTGACCACTTACTGGCTGCAGCCA 
               
               
                   
                   
                 GGGGATGATTTTGAGGAGGCTATTAGGGTATATGCAAAGGTGGCACTTAGGCCAGA 
               
               
                   
                   
                 TTGCAAGTACAAGATCAGCAAACTTGTAAATATCAGGAATTGTTGCTACATTTCTGGG 
               
               
                   
                   
                 AACGGGGCCGAGGTGGAGATAGATACGGAGGATAGGGTGGCCTTTAGATGTAGCAT 
               
               
                   
                   
                 GATAAATATGTGGCCGGGGGTGCTTGGCATGGACGGGGTGGTTATTATGAATGTAA 
               
               
                   
                   
                 GGTTTACTGGCCCCAATTTTAGCGGTACGGTTTTCCTGGCCAATACCAACCTTATCC 
               
               
                   
                   
                 TACACGGTGTAAGCTTCTATGGGTTTAACAATACCTGTGTGGAAGCCTGGACCGATG 
               
               
                   
                   
                 TAAGGGTTCGGGGCTGTGCCTTTTACTGCTGCTGGAAGGGGGTGGTGTGTCGCCCC 
               
               
                   
                   
                 AAAAGCAGGGCTTCAATTAAGAAATGCCTCTTTGAAAGGTGTACCTTGGGTATCCTG 
               
               
                   
                   
                 TCTGAGGGTAACTCCAGGGTGCGCCACAATGTGGCCTCCGACTGTGGTTGCTTCAT 
               
               
                   
                   
                 GCTAGTGAAAAGCGTGGCTGTGATTAAGCATAACATGGTATGTGGCAACTGCGAGG 
               
               
                   
                   
                 ACAGGGCCTCTCAGATGCTGACCTGCTCGGACGGCAACTGTCACCTTCTGAAGACC 
               
               
                   
                   
                 ATTCACGTAGCCAGCCACTCTCGCAAGGCCTGGCCAGTGTTTGAGCATAACATACTG 
               
               
                   
                   
                 ACCCGCTGTTCCTTGCATTTGGGTAACAGGAGGGGGGTGTTCCTACCTTACCAATGC 
               
               
                   
                   
                 AATTTGAGTCACACTAAGATATTGCTTGAGCCCGAGAGCATGTCCAAGGTGAACCTG 
               
               
                   
                   
                 AACGGGGTGTTTGACATGACCATGAAGATCTGGAAGGTGCTGAGGTACGATGAGAC 
               
               
                   
                   
                 CCGCACCAGGTGCAGACCCTGCGAGTGTGGCGGTAAACATATTAGGAACCAGCCTG 
               
               
                   
                   
                 TGATGCTGGATGTGACCGAGGAGCTGAGGCCCGATCACTTGGTGCTGGCCTGCACC 
               
               
                   
                   
                 CGCGCTGAGTTTGGCTCTAGCGATGAAGATACAGATTGAGGTACTGAAATGTGTGG 
               
               
                   
                   
                 GCGTGGCTTAAGGGTGGGAAAGAATATATAAGGTGGGGGTCTTATGTAGTTTTGTAT 
               
               
                   
                   
                 CTGTTTTGCAGCAGCCGCCGCCGCCATGAGCACCAACTCGTTTGATGGAAGCATTG 
               
               
                   
                   
                 TGAGCTCATATTTGACAACGCGCATGCCCCCATGGGCCGGGGTGCGTCAGAATGTG 
               
               
                   
                   
                 ATGGGCTCCAGCATTGATGGTCGCCCCGTCCTGCCCGCAAACTCTACTACCTTGAC 
               
               
                   
                   
                 CTACGAGACCGTGTCTGGAACGCCGTTGGAGACTGCAGCCTCCGCCGCCGCTTCA 
               
               
                   
                   
                 GCCGCTGCAGCCACCGCCCGCGGGATTGTGACTGACTTTGCTTTCCTGAGCCCGCT 
               
               
                   
                   
                 TGCAAGCAGTGCAGCTTCCCGTTCATCCGCCCGCGATGACAAGTTGACGGCTCTTTT 
               
               
                   
                   
                 GGCACAATTGGATTCTTTGACCCGGGAACTTAATGTCGTTTCTCAGCAGCTGTTGGA 
               
               
                   
                   
                 TCTGCGCCAGCAGGTTTCTGCCCTGAAGGCTTCCTCCCCTCCCAATGCGGTTTAAAA 
               
               
                   
                   
                 CATAAATAAAAAACCAGACTCTGTTTGGATTTGGATCAAGCAAGTGTCTTGCTGTCTT 
               
               
                   
                   
                 TATTTAGGGGTTTTGCGCGCGCGGTAGGCCCGGGACCAGCGGTCTCGGTCGTTGA 
               
               
                   
                   
                 GGGTCCTGTGTATTTTTTCCAGGACGTGGTAAAGGTGACTCTGGATGTTCAGATACA 
               
               
                   
                   
                 TGGGCATAAGCCCGTCTCTGGGGTGGAGGTAGCACCACTGCAGAGCTTCATGCTGC 
               
               
                   
                   
                 GGGGTGGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCGTGGTGCCTAA 
               
               
                   
                   
                 AAATGTCTTTCAGTAGCAAGCTGATTGCCAGGGGCAGGCCCTTGGTGTAAGTGTTTA 
               
               
                   
                   
                 CAAAGCGGTTAAGCTGGGATGGGTGCATACGTGGGGATATGAGATGCATCTTGGAC 
               
               
                   
                   
                 TGTATTTTTAGGTTGGCTATGTTCCCAGCCATATCCCTCCGGGGATTCATGTTGTGCA 
               
               
                   
                   
                 GAACCACCAGCACAGTGTATCCGGTGCACTTGGGAAATTTGTCATGTAGCTTAGAAG 
               
               
                   
                   
                 GAAATGCGTGGAAGAACTTGGAGACGCCCTTGTGACCTCCAAGATTTTCCATGCATT 
               
               
                   
                   
                 CGTCCATAATGATGGCAATGGGCCCACGGGCGGCGGCCTGGGCGAAGATATTTCTG 
               
               
                   
                   
                 GGATCACTAACGTCATAGTTGTGTTCCAGGATGAGATCGTCATAGGCCATTTTTACAA 
               
               
                   
                   
                 AGCGCGGGCGGAGGGTGCCAGACTGCGGTATAATGGTTCCATCCGGCCCAGGGGC 
               
               
                   
                   
                 GTAGTTACCCTCACAGATTTGCATTTCCCACGCTTTGAGTTCAGATGGGGGGATCAT 
               
               
                   
                   
                 GTCTACCTGCGGGGCGATGAAGAAAACGGTTTCCGGGGTAGGGGAGATCAGCTGG 
               
               
                   
                   
                 GAAGAAAGCAGGTTCCTGAGCAGCTGCGACTTACCGCAGCCGGTGGGCCCGTAAAT 
               
               
                   
                   
                 CACACCTATTACCGGGTGCAACTGGTAGTTAAGAGAGCTGCAGCTGCCGTCATCCC 
               
               
                   
                   
                 TGAGCAGGGGGGCCACTTCGTTAAGCATGTCCCTGACTCGCATGTTTTCCCTGACC 
               
               
                   
                   
                 AAATCCGCCAGAAGGCGCTCGCCGCCCAGCGATAGCAGTTCTTGCAAGGAAGCAAA 
               
               
                   
                   
                 GTTTTTCAACGGTTTGAGACCGTCCGCCGTAGGCATGCTTTTGAGCGTTTGACCAAG 
               
               
                   
                   
                 CAGTTCCAGGCGGTCCCACAGCTCGGTTACCTGCTCTACGGCATCTCGATCCAGCA 
               
               
                   
                   
                 TATCTCCTCGTTTCGCGGGTTGGGGCGGCTTTCGCTGTACGGCAGTAGTCGGTGCT 
               
               
                   
                   
                 CGTCCAGACGGGCCAGGGTCATGTCTTTCCACGGGCGCAGGGTCCTCGTCAGCGT 
               
               
                   
                   
                 AGTCTGGGTCACGGTGAAGGGGTGCGCTCCGGGCTGCGCGCTGGCCAGGGTGCG 
               
               
                   
                   
                 CTTGAGGCTGGTCCTGCTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCG 
               
               
                   
                   
                 GCCAGGTAGCATTTGACCATGGTGTCATAGTCCAGCCCCTCCGCGGCGTGGCCCTT 
               
               
                   
                   
                 GGCGCGCAGCTTGCCCTTGGAGGAGGCGCCGCACGAGGGGCAGTGCAGACTTTTG 
               
               
                   
                   
                 AGGGCGTAGAGCTTGGGCGCGAGAAATACCGATTCCGGGGAGTAGGCATCCGCGC 
               
               
                   
                   
                 CGCAGGCCCCGCAGACGGTCTCGCATTCCACGAGCCAGGTGAGCTCTGGCCGTTC 
               
               
                   
                   
                 GGGGTCAAAAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCTGGTTTCC 
               
               
                   
                   
                 ATGAGCCGGTGTCCACGCTCGGTGACGAAAAGGCTGTCCGTGTCCCCGTATACAGA 
               
               
                   
                   
                 CTTGAGAGGCCTGTCCTCGAGCGGTGTTCCGCGGTCCTCCTCGTATAGAAACTCGG 
               
               
                   
                   
                 ACCACTCTGAGACAAAGGCTCGCGTCCAGGCCAGCACGAAGGAGGCTAAGTGGGA 
               
               
                   
                   
                 GGGGTAGCGGTCGTTGTCCACTAGGGGGTCCACTCGCTCCAGGGTGTGAAGACAC 
               
               
                   
                   
                 ATGTCGCCCTCTTCGGCATCAAGGAAGGTGATTGGTTTGTAGGTGTAGGCCACGTG 
               
               
                   
                   
                 ACCGGGTGTTCCTGAAGGGGGGCTATAAAAGGGGGTGGGGGCGCGTTCGTCCTCA 
               
               
                   
                   
                 CTCTCTTCCGCATCGCTGTCTGCGAGGGCCAGCTGTTGGGGTGAGTACTCCCTCTG 
               
               
                   
                   
                 AAAAGCGGGCATGACTTCTGCGCTAAGATTGTCAGTTTCCAAAAACGAGGAGGATTT 
               
               
                   
                   
                 GATATTCACCTGGCCCGCGGTGATGCCTTTGAGGGTGGCCGCATCCATCTGGTCAG 
               
               
                   
                   
                 AAAAGACAATCTTTTTGTTGTCAAGCTTGGTGGCAAACGACCCGTAGAGGGCGTTGG 
               
               
                   
                   
                 ACAGCAACTTGGCGATGGAGCGCAGGGTTTGGTTTTTGTCGCGATCGGCGCGCTCC 
               
               
                   
                   
                 TTGGCCGCGATGTTTAGCTGCACGTATTCGCGCGCAACGCACCGCCATTCGGGAAA 
               
               
                   
                   
                 GACGGTGGTGCGCTCGTCGGGCACCAGGTGCACGCGCCAACCGCGGTTGTGCAGG 
               
               
                   
                   
                 GTGACAAGGTCAACGCTGGTGGCTACCTCTCCGCGTAGGCGCTCGTTGGTCCAGCA 
               
               
                   
                   
                 GAGGCGGCCGCCCTTGCGCGAGCAGAATGGCGGTAGGGGGTCTAGCTGCGTCTCG 
               
               
                   
                   
                 TCCGGGGGGTCTGCGTCCACGGTAAAGACCCCGGGCAGCAGGCGCGCGTCGAAGT 
               
               
                   
                   
                 AGTCTATCTTGCATCCTTGCAAGTCTAGCGCCTGCTGCCATGCGCGGGCGGCAAGC 
               
               
                   
                   
                 GCGCGCTCGTATGGGTTGAGTGGGGGACCCCATGGCATGGGGTGGGTGAGCGCG 
               
               
                   
                   
                 GAGGCGTACATGCCGCAAATGTCGTAAACGTAGAGGGGCTCTCTGAGTATTCCAAG 
               
               
                   
                   
                 ATATGTAGGGTAGCATCTTCCACCGCGGATGCTGGCGCGCACGTAATCGTATAGTTC 
               
               
                   
                   
                 GTGCGAGGGAGCGAGGAGGTCGGGACCGAGGTTGCTACGGGCGGGCTGCTCTGC 
               
               
                   
                   
                 TCGGAAGACTATCTGCCTGAAGATGGCATGTGAGTTGGATGATATGGTTGGACGCT 
               
               
                   
                   
                 GGAAGACGTTGAAGCTGGCGTCTGTGAGACCTACCGCGTCACGCACGAAGGAGGC 
               
               
                   
                   
                 GTAGGAGTCGCGCAGCTTGTTGACCAGCTCGGCGGTGACCTGCACGTCTAGGGCG 
               
               
                   
                   
                 CAGTAGTCCAGGGTTTCCTTGATGATGTCATACTTATCCTGTCCCTTTTTTTTCCACA 
               
               
                   
                   
                 GCTCGCGGTTGAGGACAAACTCTTCGCGGTCTTTCCAGTACTCTTGGATCGGAAACC 
               
               
                   
                   
                 CGTCGGCCTCCGAACGGTAAGAGCCTAGCATGTAGAACTGGTTGACGGCCTGGTAG 
               
               
                   
                   
                 GCGCAGCATCCCTTTTCTACGGGTAGCGCGTATGCCTGCGCGGCCTTCCGGAGCGA 
               
               
                   
                   
                 GGTGTGGGTGAGCGCAAAGGTGTCCCTGACCATGACTTTGAGGTACTGGTATTTGA 
               
               
                   
                   
                 AGTCAGTGTCGTCGCATCCGCCCTGCTCCCAGAGCAAAAAGTCCGTGCGCTTTTTG 
               
               
                   
                   
                 GAACGCGGATTTGGCAGGGCGAAGGTGACATCGTTGAAGAGTATCTTTCCCGCGCG 
               
               
                   
                   
                 AGGCATAAAGTTGCGTGTGATGCGGAAGGGTCCCGGCACCTCGGAACGGTTGTTAA 
               
               
                   
                   
                 TTACCTGGGCGGCGAGCACGATCTCGTCAAAGCCGTTGATGTTGTGGCCCACAATG 
               
               
                   
                   
                 TAAAGTTCCAAGAAGCGCGGGATGCCCTTGATGGAAGGCAATTTTTTAAGTTCCTCG 
               
               
                   
                   
                 TAGGTGAGCTCTTCAGGGGAGCTGAGCCCGTGCTCTGAAAGGGCCCAGTCTGCAAG 
               
               
                   
                   
                 ATGAGGGTTGGAAGCGACGAATGAGCTCCACAGGTCACGGGCCATTAGCATTTGCA 
               
               
                   
                   
                 GGTGGTCGCGAAAGGTCCTAAACTGGCGACCTATGGCCATTTTTTCTGGGGTGATG 
               
               
                   
                   
                 CAGTAGAAGGTAAGCGGGTCTTGTTCCCAGCGGTCCCATCCAAGGTTCGCGGCTAG 
               
               
                   
                   
                 GTCTCGCGCGGCAGTCACTAGAGGCTCATCTCCGCCGAACTTCATGACCAGCATGA 
               
               
                   
                   
                 AGGGCACGAGCTGCTTCCCAAAGGCCCCCATCCAAGTATAGGTCTCTACATCGTAG 
               
               
                   
                   
                 GTGACAAAGAGACGCTCGGTGCGAGGATGCGAGCCGATCGGGAAGAACTGGATCT 
               
               
                   
                   
                 CCCGCCACCAATTGGAGGAGTGGCTATTGATGTGGTGAAAGTAGAAGTCCCTGCGA 
               
               
                   
                   
                 CGGGCCGAACACTCGTGCTGGCTTTTGTAAAAACGTGCGCAGTACTGGCAGCGGTG 
               
               
                   
                   
                 CACGGGCTGTACATCCTGCACGAGGTTGACCTGACGACCGCGCACAAGGAAGCAG 
               
               
                   
                   
                 AGTGGGAATTTGAGCCCCTCGCCTGGCGGGTTTGGCTGGTGGTCTTCTACTTCGGC 
               
               
                   
                   
                 TGCTTGTCCTTGACCGTCTGGCTGCTCGAGGGGAGTTACGGTGGATCGGACCACCA 
               
               
                   
                   
                 CGCCGCGCGAGCCCAAAGTCCAGATGTCCGCGCGCGGCGGTCGGAGCTTGATGAC 
               
               
                   
                   
                 AACATCGCGCAGATGGGAGCTGTCCATGGTCTGGAGCTCCCGCGGCGTCAGGTCA 
               
               
                   
                   
                 GGCGGGAGCTCCTGCAGGTTTACCTCGCATAGACGGGTCAGGGCGCGGGCTAGAT 
               
               
                   
                   
                 CCAGGTGATACCTAATTTCCAGGGGCTGGTTGGTGGCGGCGTCGATGGCTTGCAAG 
               
               
                   
                   
                 AGGCCGCATCCCCGCGGCGCGACTACGGTACCGCGCGGCGGGCGGTGGGCCGCG 
               
               
                   
                   
                 GGGGTGTCCTTGGATGATGCATCTAAAAGCGGTGACGCGGGCGAGCCCCCGGAGG 
               
               
                   
                   
                 TAGGGGGGGCTCCGGACCCGCCGGGAGAGGGGGCAGGGGCACGTCGGCGCCGC 
               
               
                   
                   
                 GCGCGGGCAGGAGCTGGTGCTGCGCGCGTAGGTTGCTGGCGAACGCGACGACGC 
               
               
                   
                   
                 GGCGGTTGATCTCCTGAATCTGGCGCCTCTGCGTGAAGACGACGGGCCCGGTGAG 
               
               
                   
                   
                 CTTGAGCCTGAAAGAGAGTTCGACAGAATCAATTTCGGTGTCGTTGACGGCGGCCT 
               
               
                   
                   
                 GGCGCAAAATCTCCTGCACGTCTCCTGAGTTGTCTTGATAGGCGATCTCGGCCATGA 
               
               
                   
                   
                 ACTGCTCGATCTCTTCCTCCTGGAGATCTCCGCGTCCGGCTCGCTCCACGGTGGCG 
               
               
                   
                   
                 GCGAGGTCGTTGGAAATGCGGGCCATGAGCTGCGAGAAGGCGTTGAGGCCTCCCT 
               
               
                   
                   
                 CGTTCCAGACGCGGCTGTAGACCACGCCCCCTTCGGCATCGCGGGCGCGCATGAC 
               
               
                   
                   
                 CACCTGCGCGAGATTGAGCTCCACGTGCCGGGCGAAGACGGCGTAGTTTCGCAGG 
               
               
                   
                   
                 CGCTGAAAGAGGTAGTTGAGGGTGGTGGCGGTGTGTTCTGCCACGAAGAAGTACAT 
               
               
                   
                   
                 AACCCAGCGTCGCAACGTGGATTCGTTGATATCCCCCAAGGCCTCAAGGCGCTCCA 
               
               
                   
                   
                 TGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGGGAGTTGCGCGCCGACACG 
               
               
                   
                   
                 GTTAACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACAGTGTCGCGCACCTCGCG 
               
               
                   
                   
                 CTCAAAGGCTACAGGGGCCTCTTCTTCTTCTTCAATCTCCTCTTCCATAAGGGCCTC 
               
               
                   
                   
                 CCCTTCTTCTTCTTCTGGCGGCGGTGGGGGAGGGGGGACACGGCGGCGACGACGG 
               
               
                   
                   
                 CGCACCGGGAGGCGGTCGACAAAGCGCTCGATCATCTCCCCGCGGCGACGGCGCA 
               
               
                   
                   
                 TGGTCTCGGTGACGGCGCGGCCGTTCTCGCGGGGGCGCAGTTGGAAGACGCCGC 
               
               
                   
                   
                 CCGTCATGTCCCGGTTATGGGTTGGCGGGGGGCTGCCATGCGGCAGGGATACGGC 
               
               
                   
                   
                 GCTAACGATGCATCTCAACAATTGTTGTGTAGGTACTCCGCCGCCGAGGGACCTGA 
               
               
                   
                   
                 GCGAGTCCGCATCGACCGGATCGGAAAACCTCTCGAGAAAGGCGTCTAACCAGTCA 
               
               
                   
                   
                 CAGTCGCAAGGTAGGCTGAGCACCGTGGCGGGCGGCAGCGGGCGGCGGTCGGGG 
               
               
                   
                   
                 TTGTTTCTGGCGGAGGTGCTGCTGATGATGTAATTAAAGTAGGCGGTCTTGAGACGG 
               
               
                   
                   
                 CGGATGGTCGACAGAAGCACCATGTCCTTGGGTCCGGCCTGCTGAATGCGCAGGC 
               
               
                   
                   
                 GGTCGGCCATGCCCCAGGCTTCGTTTTGACATCGGCGCAGGTCTTTGTAGTAGTCTT 
               
               
                   
                   
                 GCATGAGCCTTTCTACCGGCACTTCTTCTTCTCCTTCCTCTTGTCCTGCATCTCTTGC 
               
               
                   
                   
                 ATCTATCGCTGCGGCGGCGGCGGAGTTTGGCCGTAGGTGGCGCCCTCTTCCTCCC 
               
               
                   
                   
                 ATGCGTGTGACCCCGAAGCCCCTCATCGGCTGAAGCAGGGCTAGGTCGGCGACAA 
               
               
                   
                   
                 CGCGCTCGGCTAATATGGCCTGCTGCACCTGCGTGAGGGTAGACTGGAAGTCATCC 
               
               
                   
                   
                 ATGTCCACAAAGCGGTGGTATGCGCCCGTGTTGATGGTGTAAGTGCAGTTGGCCAT 
               
               
                   
                   
                 AACGGACCAGTTAACGGTCTGGTGACCCGGCTGCGAGAGCTCGGTGTACCTGAGAC 
               
               
                   
                   
                 GCGAGTAAGCCCTCGAGTCAAATACGTAGTCGTTGCAAGTCCGCACCAGGTACTGG 
               
               
                   
                   
                 TATCCCACCAAAAAGTGCGGCGGCGGCTGGCGGTAGAGGGGCCAGCGTAGGGTGG 
               
               
                   
                   
                 CCGGGGCTCCGGGGGCGAGATCTTCCAACATAAGGCGATGATATCCGTAGATGTAC 
               
               
                   
                   
                 CTGGACATCCAGGTGATGCCGGCGGCGGTGGTGGAGGCGCGCGGAAAGTCGCGG 
               
               
                   
                   
                 ACGCGGTTCCAGATGTTGCGCAGCGGCAAAAAGTGCTCCATGGTCGGGACGCTCTG 
               
               
                   
                   
                 GCCGGTCAGGCGCGCGCAATCGTTGACGCTCTAGACCGTGCAAAAGGAGAGCCTG 
               
               
                   
                   
                 TAAGCGGGCACTCTTCCGTGGTCTGGTGGATAAATTCGCAAGGGTATCATGGCGGA 
               
               
                   
                   
                 CGACCGGGGTTCGAGCCCCGTATCCGGCCGTCCGCCGTGATCCATGCGGTTACCG 
               
               
                   
                   
                 CCCGCGTGTCGAACCCAGGTGTGCGACGTCAGACAACGGGGGAGTGCTCCTTTTG 
               
               
                   
                   
                 GCTTCCTTCCAGGCGCGGCGGCTGCTGCGCTAGCTTTTTTGGCCACTGGCCGCGC 
               
               
                   
                   
                 GCAGCGTAAGCGGTTAGGCTGGAAAGCGAAAGCATTAAGTGGCTCGCTCCCTGTAG 
               
               
                   
                   
                 CCGGAGGGTTATTTTCCAAGGGTTGAGTCGCGGGACCCCCGGTTCGAGTCTCGGAC 
               
               
                   
                   
                 CGGCCGGACTGCGGCGAACGGGGGTTTGCCTCCCCGTCATGCAAGACCCCGCTTG 
               
               
                   
                   
                 CAAATTCCTCCGGAAACAGGGACGAGCCCCTTTTTTGCTTTTCCCAGATGCATCCGG 
               
               
                   
                   
                 TGCTGCGGCAGATGCGCCCCCCTCCTCAGCAGCGGCAAGAGCAAGAGCAGCGGCA 
               
               
                   
                   
                 GACATGCAGGGCACCCTCCCCTCCTCCTACCGCGTCAGGAGGGGCGACATCCGCG 
               
               
                   
                   
                 GTTGACGCGGCAGCAGATGGTGATTACGAACCCCCGCGGCGCCGGGCCCGGCACT 
               
               
                   
                   
                 ACCTGGACTTGGAGGAGGGCGAGGGCCTGGCGCGGCTAGGAGCGCCCTCTCCTGA 
               
               
                   
                   
                 GCGGTACCCAAGGGTGCAGCTGAAGCGTGATACGCGTGAGGCGTACGTGCCGCGG 
               
               
                   
                   
                 CAGAACCTGTTTCGCGACCGCGAGGGAGAGGAGCCCGAGGAGATGCGGGATCGAA 
               
               
                   
                   
                 AGTTCCACGCAGGGCGCGAGCTGCGGCATGGCCTGAATCGCGAGCGGTTGCTGCG 
               
               
                   
                   
                 CGAGGAGGACTTTGAGCCCGACGCGCGAACCGGGATTAGTCCCGCGCGCGCACAC 
               
               
                   
                   
                 GTGGCGGCCGCCGACCTGGTAACCGCATACGAGCAGACGGTGAACCAGGAGATTA 
               
               
                   
                   
                 ACTTTCAAAAAAGCTTTAACAACCACGTGCGTACGCTTGTGGCGCGCGAGGAGGTG 
               
               
                   
                   
                 GCTATAGGACTGATGCATCTGTGGGACTTTGTAAGCGCGCTGGAGCAAAACCCAAAT 
               
               
                   
                   
                 AGCAAGCCGCTCATGGCGCAGCTGTTCCTTATAGTGCAGCACAGCAGGGACAACGA 
               
               
                   
                   
                 GGCATTCAGGGATGCGCTGCTAAACATAGTAGAGCCCGAGGGCCGCTGGCTGCTC 
               
               
                   
                   
                 GATTTGATAAACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCTTGAGCCTGGC 
               
               
                   
                   
                 TGACAAGGTGGCCGCCATCAACTATTCCATGCTTAGCCTGGGCAAGTTTTACGCCCG 
               
               
                   
                   
                 CAAGATATACCATACCCCTTACGTTCCCATAGACAAGGAGGTAAAGATCGAGGGGTT 
               
               
                   
                   
                 CTACATGCGCATGGCGCTGAAGGTGCTTACCTTGAGCGACGACCTGGGCGTTTATC 
               
               
                   
                   
                 GCAACGAGCGCATCCACAAGGCCGTGAGCGTGAGCCGGCGGCGCGAGCTCAGCG 
               
               
                   
                   
                 ACCGCGAGCTGATGCACAGCCTGCAAAGGGCCCTGGCTGGCACGGGCAGCGGCGA 
               
               
                   
                   
                 TAGAGAGGCCGAGTCCTACTTTGACGCGGGCGCTGACCTGCGCTGGGCCCCAAGC 
               
               
                   
                   
                 CGACGCGCCCTGGAGGCAGCTGGGGCCGGACCTGGGCTGGCGGTGGCACCCGCG 
               
               
                   
                   
                 CGCGCTGGCAACGTCGGCGGCGTGGAGGAATATGACGAGGACGATGAGTACGAGC 
               
               
                   
                   
                 CAGAGGACGGCGAGTACTAAGCGGTGATGTTTCTGATCAGATGATGCAAGACGCAA 
               
               
                   
                   
                 CGGACCCGGCGGTGCGGGCGGCGCTGCAGAGCCAGCCGTCCGGCCTTAACTCCA 
               
               
                   
                   
                 CGGACGACTGGCGCCAGGTCATGGACCGCATCATGTCGCTGACTGCGCGCAATCCT 
               
               
                   
                   
                 GACGCGTTCCGGCAGCAGCCGCAGGCCAACCGGCTCTCCGCAATTCTGGAAGCGG 
               
               
                   
                   
                 TGGTCCCGGCGCGCGCAAACCCCACGCACGAGAAGGTGCTGGCGATCGTAAACGC 
               
               
                   
                   
                 GCTGGCCGAAAACAGGGCCATCCGGCCCGACGAGGCCGGCCTGGTCTACGACGCG 
               
               
                   
                   
                 CTGCTTCAGCGCGTGGCTCGTTACAACAGCGGCAACGTGCAGACCAACCTGGACCG 
               
               
                   
                   
                 GCTGGTGGGGGATGTGCGCGAGGCCGTGGCGCAGCGTGAGCGCGCGCAGCAGCA 
               
               
                   
                   
                 GGGCAACCTGGGCTCCATGGTTGCACTAAACGCCTTCCTGAGTACACAGCCCGCCA 
               
               
                   
                   
                 ACGTGCCGCGGGGACAGGAGGACTACACCAACTTTGTGAGCGCACTGCGGCTAAT 
               
               
                   
                   
                 GGTGACTGAGACACCGCAAAGTGAGGTGTACCAGTCTGGGCCAGACTATTTTTTCCA 
               
               
                   
                   
                 GACCAGTAGACAAGGCCTGCAGACCGTAAACCTGAGCCAGGCTTTCAAAAACTTGC 
               
               
                   
                   
                 AGGGGCTGTGGGGGGTGCGGGCTCCCACAGGCGACCGCGCGACCGTGTCTAGCTT 
               
               
                   
                   
                 GCTGACGCCCAACTCGCGCCTGTTGCTGCTGCTAATAGCGCCCTTCACGGACAGTG 
               
               
                   
                   
                 GCAGCGTGTCCCGGGACACATACCTAGGTCACTTGCTGACACTGTACCGCGAGGCC 
               
               
                   
                   
                 ATAGGTCAGGCGCATGTGGACGAGCATACTTTCCAGGAGATTACAAGTGTCAGCCG 
               
               
                   
                   
                 CGCGCTGGGGCAGGAGGACACGGGCAGCCTGGAGGCAACCCTAAACTACCTGCTG 
               
               
                   
                   
                 ACCAACCGGCGGCAGAAGATCCCCTCGTTGCACAGTTTAAACAGCGAGGAGGAGCG 
               
               
                   
                   
                 CATTTTGCGCTACGTGCAGCAGAGCGTGAGCCTTAACCTGATGCGCGACGGGGTAA 
               
               
                   
                   
                 CGCCCAGCGTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCATGTATGC 
               
               
                   
                   
                 CTCAAACCGGCCGTTTATCAACCGCCTAATGGACTACTTGCATCGCGCGGCCGCCG 
               
               
                   
                   
                 TGAACCCCGAGTATTTCACCAATGCCATCTTGAACCCGCACTGGCTACCGCCCCCTG 
               
               
                   
                   
                 GTTTCTACACCGGGGGATTCGAGGTGCCCGAGGGTAACGATGGATTCCTCTGGGAC 
               
               
                   
                   
                 GACATAGACGACAGCGTGTTTTCCCCGCAACCGCAGACCCTGCTAGAGTTGCAACA 
               
               
                   
                   
                 GCGCGAGCAGGCAGAGGCGGCGCTGCGAAAGGAAAGCTTCCGCAGGCCAAGCAG 
               
               
                   
                   
                 CTTGTCCGATCTAGGCGCTGCGGCCCCGCGGTCAGATGCTAGTAGCCCATTTCCAA 
               
               
                   
                   
                 GCTTGATAGGGTCTCTTACCAGCACTCGCACCACCCGCCCGCGCCTGCTGGGCGA 
               
               
                   
                   
                 GGAGGAGTACCTAAACAACTCGCTGCTGCAGCCGCAGCGCGAAAAAAACCTGCCTC 
               
               
                   
                   
                 CGGCATTTCCCAACAACGGGATAGAGAGCCTAGTGGACAAGATGAGTAGATGGAAG 
               
               
                   
                   
                 ACGTACGCGCAGGAGCACAGGGACGTGCCAGGCCCGCGCCCGCCCACCCGTCGT 
               
               
                   
                   
                 CAAAGGCACGACCGTCAGCGGGGTCTGGTGTGGGAGGACGATGACTCGGCAGACG 
               
               
                   
                   
                 ACAGCAGCGTCCTGGATTTGGGAGGGAGTGGCAACCCGTTTGCGCACCTTCGCCCC 
               
               
                   
                   
                 AGGCTGGGGAGAATGTTTTAAAAAAAAAAAAGCATGATGCAAAATAAAAAACTCACCA 
               
               
                   
                   
                 AGGCCATGGCACCGAGCGTTGGTTTTCTTGTATTCCCCTTAGTATGCGGCGCGCGG 
               
               
                   
                   
                 CGATGTATGAGGAAGGTCCTCCTCCCTCCTACGAGAGTGTGGTGAGCGCGGCGCCA 
               
               
                   
                   
                 GTGGCGGCGGCGCTGGGTTCTCCCTTCGATGCTCCCCTGGACCCGCCGTTTGTGC 
               
               
                   
                   
                 CTCCGCGGTACCTGCGGCCTACCGGGGGGAGAAACAGCATCCGTTACTCTGAGTTG 
               
               
                   
                   
                 GCACCCCTATTCGACACCACCCGTGTGTACCTGGTGGACAACAAGTCAACGGATGT 
               
               
                   
                   
                 GGCATCCCTGAACTACCAGAACGACCACAGCAACTTTCTGACCACGGTCATTCAAAA 
               
               
                   
                   
                 CAATGACTACAGCCCGGGGGAGGCAAGCACACAGACCATCAATCTTGACGACCGGT 
               
               
                   
                   
                 CGCACTGGGGCGGCGACCTGAAAACCATCCTGCATACCAACATGCCAAATGTGAAC 
               
               
                   
                   
                 GAGTTCATGTTTACCAATAAGTTTAAGGCGCGGGTGATGGTGTCGCGCTTGCCTACT 
               
               
                   
                   
                 AAGGACAATCAGGTGGAGCTGAAATACGAGTGGGTGGAGTTCACGCTGCCCGAGG 
               
               
                   
                   
                 GCAACTACTCCGAGACCATGACCATAGACCTTATGAACAACGCGATCGTGGAGCACT 
               
               
                   
                   
                 ACTTGAAAGTGGGCAGACAGAACGGGGTTCTGGAAAGCGACATCGGGGTAAAGTTT 
               
               
                   
                   
                 GACACCCGCAACTTCAGACTGGGGTTTGACCCCGTCACTGGTCTTGTCATGCCTGG 
               
               
                   
                   
                 GGTATATACAAACGAAGCCTTCCATCCAGACATCATTTTGCTGCCAGGATGCGGGGT 
               
               
                   
                   
                 GGACTTCACCCACAGCCGCCTGAGCAACTTGTTGGGCATCCGCAAGCGGCAACCCT 
               
               
                   
                   
                 TCCAGGAGGGCTTTAGGATCACCTACGATGATCTGGAGGGTGGTAACATTCCCGCA 
               
               
                   
                   
                 CTGTTGGATGTGGACGCCTACCAGGCGAGCTTGAAAGATGACACCGAACAGGGCG 
               
               
                   
                   
                 GGGGTGGCGCAGGCGGCAGCAACAGCAGTGGCAGCGGCGCGGAAGAGAACTCCA 
               
               
                   
                   
                 ACGCGGCAGCCGCGGCAATGCAGCCGGTGGAGGACATGAACGATCATGCCATTCG 
               
               
                   
                   
                 CGGCGACACCTTTGCCACACGGGCTGAGGAGAAGCGCGCTGAGGCCGAAGCAGCG 
               
               
                   
                   
                 GCCGAAGCTGCCGCCCCCGCTGCGCAACCCGAGGTCGAGAAGCCTCAGAAGAAAC 
               
               
                   
                   
                 CGGTGATCAAACCCCTGACAGAGGACAGCAAGAAACGCAGTTACAACCTAATAAGC 
               
               
                   
                   
                 AATGACAGCACCTTCACCCAGTACCGCAGCTGGTACCTTGCATACAACTACGGCGA 
               
               
                   
                   
                 CCCTCAGACCGGAATCCGCTCATGGACCCTGCTTTGCACTCCTGACGTAACCTGCG 
               
               
                   
                   
                 GCTCGGAGCAGGTCTACTGGTCGTTGCCAGACATGATGCAAGACCCCGTGACCTTC 
               
               
                   
                   
                 CGCTCCACGCGCCAGATCAGCAACTTTCCGGTGGTGGGCGCCGAGCTGTTGCCCG 
               
               
                   
                   
                 TGCACTCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAACTCATCCGCCAGT 
               
               
                   
                   
                 TTACCTCTCTGACCCACGTGTTCAATCGCTTTCCCGAGAACCAGATTTTGGCGCGCC 
               
               
                   
                   
                 CGCCAGCCCCCACCATCACCACCGTCAGTGAAAACGTTCCTGCTCTCACAGATCAC 
               
               
                   
                   
                 GGGACGCTACCGCTGCGCAACAGCATCGGAGGAGTCCAGCGAGTGACCATTACTG 
               
               
                   
                   
                 ACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGCCCTGGGCATAGTCTCGCCG 
               
               
                   
                   
                 CGCGTCCTATCGAGCCGCACTTTTTGAGCAAGCATGTCCATCCTTATATCGCCCAGC 
               
               
                   
                   
                 AATAACACAGGCTGGGGCCTGCGCTTCCCAAGCAAGATGTTTGGCGGGGCCAAGAA 
               
               
                   
                   
                 GCGCTCCGACCAACACCCAGTGCGCGTGCGCGGGCACTACCGCGCGCCCTGGGG 
               
               
                   
                   
                 CGCGCACAAACGCGGCCGCACTGGGCGCACCACCGTCGATGACGCCATCGACGCG 
               
               
                   
                   
                 GTGGTGGAGGAGGCGCGCAACTACACGCCCACGCCGCCACCAGTGTCCACAGTGG 
               
               
                   
                   
                 ACGCGGCCATTCAGACCGTGGTGCGCGGAGCCCGGCGCTATGCTAAAATGAAGAG 
               
               
                   
                   
                 ACGGCGGAGGCGCGTAGCACGTCGCCACCGCCGCCGACCCGGCACTGCCGCCCA 
               
               
                   
                   
                 ACGCGCGGCGGCGGCCCTGCTTAACCGCGCACGTCGCACCGGCCGACGGGCGGC 
               
               
                   
                   
                 CATGCGGGCCGCTCGAAGGCTGGCCGCGGGTATTGTCACTGTGCCCCCCAGGTCC 
               
               
                   
                   
                 AGGCGACGAGCGGCCGCCGCAGCAGCCGCGGCCATTAGTGCTATGACTCAGGGTC 
               
               
                   
                   
                 GCAGGGGCAACGTGTATTGGGTGCGCGACTCGGTTAGCGGCCTGCGCGTGCCCGT 
               
               
                   
                   
                 GCGCACCCGCCCCCCGCGCAACTAGATTGCAAGAAAAAACTACTTAGACTCGTACT 
               
               
                   
                   
                 GTTGTATGTATCCAGCGGCGGCGGCGCGCAACGAAGCTATGTCCAAGCGCAAAATC 
               
               
                   
                   
                 AAAGAAGAGATGCTCCAGGTCATCGCGCCGGAGATCTATGGCCCCCCGAAGAAGGA 
               
               
                   
                   
                 AGAGCAGGATTACAAGCCCCGAAAGCTAAAGCGGGTCAAAAAGAAAAAGAAAGATG 
               
               
                   
                   
                 ATGATGATGAACTTGACGACGAGGTGGAACTGCTGCACGCTACCGCGCCCAGGCGA 
               
               
                   
                   
                 CGGGTACAGTGGAAAGGTCGACGCGTAAAACGTGTTTTGCGACCCGGCACCACCGT 
               
               
                   
                   
                 AGTCTTTACGCCCGGTGAGCGCTCCACCCGCACCTACAAGCGCGTGTATGATGAGG 
               
               
                   
                   
                 TGTACGGCGACGAGGACCTGCTTGAGCAGGCCAACGAGCGCCTCGGGGAGTTTGC 
               
               
                   
                   
                 CTACGGAAAGCGGCATAAGGACATGCTGGCGTTGCCGCTGGACGAGGGCAACCCA 
               
               
                   
                   
                 ACACCTAGCCTAAAGCCCGTAACACTGCAGCAGGTGCTGCCCGCGCTTGCACCGTC 
               
               
                   
                   
                 CGAAGAAAAGCGCGGCCTAAAGCGCGAGTCTGGTGACTTGGCACCCACCGTGCAG 
               
               
                   
                   
                 CTGATGGTACCCAAGCGCCAGCGACTGGAAGATGTCTTGGAAAAAATGACCGTGGA 
               
               
                   
                   
                 ACCTGGGCTGGAGCCCGAGGTCCGCGTGCGGCCAATCAAGCAGGTGGCGCCGGG 
               
               
                   
                   
                 ACTGGGCGTGCAGACCGTGGACGTTCAGATACCCACTACCAGTAGCACCAGTATTG 
               
               
                   
                   
                 CCACCGCCACAGAGGGCATGGAGACACAAACGTCCCCGGTTGCCTCAGCGGTGGC 
               
               
                   
                   
                 GGATGCCGCGGTGCAGGCGGTCGCTGCGGCCGCGTCCAAGACCTCTACGGAGGTG 
               
               
                   
                   
                 CAAACGGACCCGTGGATGTTTCGCGTTTCAGCCCCCCGGCGCCCGCGCGGTTCGA 
               
               
                   
                   
                 GGAAGTACGGCGCCGCCAGCGCGCTACTGCCCGAATATGCCCTACATCCTTCCATT 
               
               
                   
                   
                 GCGCCTACCCCCGGCTATCGTGGCTACACCTACCGCCCCAGAAGACGAGCAACTAC 
               
               
                   
                   
                 CCGACGCCGAACCACCACTGGAACCCGCCGCCGCCGTCGCCGTCGCCAGCCCGTG 
               
               
                   
                   
                 CTGGCCCCGATTTCCGTGCGCAGGGTGGCTCGCGAAGGAGGCAGGACCCTGGTGC 
               
               
                   
                   
                 TGCCAACAGCGCGCTACCACCCCAGCATCGTTTAAAAGCCGGTCTTTGTGGTTCTTG 
               
               
                   
                   
                 CAGATATGGCCCTCACCTGCCGCCTCCGTTTCCCGGTGCCGGGATTCCGAGGAAGA 
               
               
                   
                   
                 ATGCACCGTAGGAGGGGCATGGCCGGCCACGGCCTGACGGGCGGCATGCGTCGT 
               
               
                   
                   
                 GCGCACCACCGGCGGCGGCGCGCGTCGCACCGTCGCATGCGCGGCGGTATCCTG 
               
               
                   
                   
                 CCCCTCCTTATTCCACTGATCGCCGCGGCGATTGGCGCCGTGCCCGGAATTGCATC 
               
               
                   
                   
                 CGTGGCCTTGCAGGCGCAGAGACACTGATTAAAAACAAGTTGCATGTGGAAAAATCA 
               
               
                   
                   
                 AAATAAAAAGTCTGGACTCTCACGCTCGCTTGGTCCTGTAACTATTTTGTAGAATGGA 
               
               
                   
                   
                 AGACATCAACTTTGCGTCTCTGGCCCCGCGACACGGCTCGCGCCCGTTCATGGGAA 
               
               
                   
                   
                 ACTGGCAAGATATCGGCACCAGCAATATGAGCGGTGGCGCCTTCAGCTGGGGCTCG 
               
               
                   
                   
                 CTGTGGAGCGGCATTAAAAATTTCGGTTCCACCGTTAAGAACTATGGCAGCAAGGCC 
               
               
                   
                   
                 TGGAACAGCAGCACAGGCCAGATGCTGAGGGATAAGTTGAAAGAGCAAAATTTCCA 
               
               
                   
                   
                 ACAAAAGGTGGTAGATGGCCTGGCCTCTGGCATTAGCGGGGTGGTGGACCTGGCC 
               
               
                   
                   
                 AACCAGGCAGTGCAAAATAAGATTAACAGTAAGCTTGATCCCCGCCCTCCCGTAGAG 
               
               
                   
                   
                 GAGCCTCCACCGGCCGTGGAGACAGTGTCTCCAGAGGGGCGTGGCGAAAAGCGTC 
               
               
                   
                   
                 CGCGCCCCGACAGGGAAGAAACTCTGGTGACGCAAATAGACGAGCCTCCCTCGTAC 
               
               
                   
                   
                 GAGGAGGCACTAAAGCAAGGCCTGCCCACCACCCGTCCCATCGCGCCCATGGCTA 
               
               
                   
                   
                 CCGGAGTGCTGGGCCAGCACACACCCGTAACGCTGGACCTGCCTCCCCCCGCCGA 
               
               
                   
                   
                 CACCCAGCAGAAACCTGTGCTGCCAGGCCCGACCGCCGTTGTTGTAACCCGTCCTA 
               
               
                   
                   
                 GCCGCGCGTCCCTGCGCCGCGCCGCCAGCGGTCCGCGATCGTTGCGGCCCGTAG 
               
               
                   
                   
                 CCAGTGGCAACTGGCAAAGCACACTGAACAGCATCGTGGGTCTGGGGGTGCAATCC 
               
               
                   
                   
                 CTGAAGCGCCGACGATGCTTCTGAATAGCTAACGTGTCGTATGTGTGTCATGTATGC 
               
               
                   
                   
                 GTCCATGTCGCCGCCAGAGGAGCTGCTGAGCCGCCGCGCGCCCGCTTTCCAAGAT 
               
               
                   
                   
                 GGCTACCCCTTCGATGATGCCGCAGTGGTCTTACATGCACATCTCGGGCCAGGACG 
               
               
                   
                   
                 CCTCGGAGTACCTGAGCCCCGGGCTGGTGCAGTTTGCCCGCGCCACCGAGACGTA 
               
               
                   
                   
                 CTTCAGCCTGAATAACAAGTTTAGAAACCCCACGGTGGCGCCTACGCACGACGTGA 
               
               
                   
                   
                 CCACAGACCGGTCCCAGCGTTTGACGCTGCGGTTCATCCCTGTGGACCGTGAGGAT 
               
               
                   
                   
                 ACTGCGTACTCGTACAAGGCGCGGTTCACCCTAGCTGTGGGTGATAACCGTGTGCT 
               
               
                   
                   
                 GGACATGGCTTCCACGTACTTTGACATCCGCGGCGTGCTGGACAGGGGCCCTACTT 
               
               
                   
                   
                 TTAAGCCCTACTCTGGCACTGCCTACAACGCCCTGGCTCCCAAGGGTGCCCCAAAT 
               
               
                   
                   
                 CCTTGCGAATGGGATGAAGCTGCTACTGCTCTTGAAATAAACCTAGAAGAAGAGGAC 
               
               
                   
                   
                 GATGACAACGAAGACGAAGTAGACGAGCAAGCTGAGCAGCAAAAAACTCACGTATTT 
               
               
                   
                   
                 GGGCAGGCGCCTTATTCTGGTATAAATATTACAAAGGAGGGTATTCAAATAGGTGTC 
               
               
                   
                   
                 GAAGGTCAAACACCTAAATATGCCGATAAAACATTTCAACCTGAACCTCAAATAGGA 
               
               
                   
                   
                 GAATCTCAGTGGTACGAAACTGAAATTAATCATGCAGCTGGGAGAGTCCTTAAAAAG 
               
               
                   
                   
                 ACTACCCCAATGAAACCATGTTACGGTTCATATGCAAAACCCACAAATGAAAATGGA 
               
               
                   
                   
                 GGGCAAGGCATTCTTGTAAAGCAACAAAATGGAAAGCTAGAAAGTCAAGTGGAAATG 
               
               
                   
                   
                 CAATTTTTCTCAACTACTGAGGCGACCGCAGGCAATGGTGATAACTTGACTCCTAAA 
               
               
                   
                   
                 GTGGTATTGTACAGTGAAGATGTAGATATAGAAACCCCAGACACTCATATTTCTTACA 
               
               
                   
                   
                 TGCCCACTATTAAGGAAGGTAACTCACGAGAACTAATGGGCCAACAATCTATGCCCA 
               
               
                   
                   
                 ACAGGCCTAATTACATTGCTTTTAGGGACAATTTTATTGGTCTAATGTATTACAACAG 
               
               
                   
                   
                 CACGGGTAATATGGGTGTTCTGGCGGGCCAAGCATCGCAGTTGAATGCTGTTGTAG 
               
               
                   
                   
                 ATTTGCAAGACAGAAACACAGAGCTTTCATACCAGCTTTTGCTTGATTCCATTGGTGA 
               
               
                   
                   
                 TAGAACCAGGTACTTTTCTATGTGGAATCAGGCTGTTGACAGCTATGATCCAGATGTT 
               
               
                   
                   
                 AGAATTATTGAAAATCATGGAACTGAAGATGAACTTCCAAATTACTGCTTTCCACTGG 
               
               
                   
                   
                 GAGGTGTGATTAATACAGAGACTCTTACCAAGGTAAAACCTAAAACAGGTCAGGAAA 
               
               
                   
                   
                 ATGGATGGGAAAAAGATGCTACAGAATTTTCAGATAAAAATGAAATAAGAGTTGGAAA 
               
               
                   
                   
                 TAATTTTGCCATGGAAATCAATCTAAATGCCAACCTGTGGAGAAATTTCCTGTACTCC 
               
               
                   
                   
                 AACATAGCGCTGTATTTGCCCGACAAGCTAAAGTACAGTCCTTCCAACGTAAAAATTT 
               
               
                   
                   
                 CTGATAACCCAAACACCTACGACTACATGAACAAGCGAGTGGTGGCTCCCGGGTTA 
               
               
                   
                   
                 GTGGACTGCTACATTAACCTTGGAGCACGCTGGTCCCTTGACTATATGGACAACGTC 
               
               
                   
                   
                 AACCCATTTAACCACCACCGCAATGCTGGCCTGCGCTACCGCTCAATGTTGCTGGG 
               
               
                   
                   
                 CAATGGTCGCTATGTGCCCTTCCACATCCAGGTGCCTCAGAAGTTCTTTGCCATTAA 
               
               
                   
                   
                 AAACCTCCTTCTCCTGCCGGGCTCATACACCTACGAGTGGAACTTCAGGAAGGATGT 
               
               
                   
                   
                 TAACATGGTTCTGCAGAGCTCCCTAGGAAATGACCTAAGGGTTGACGGAGCCAGCA 
               
               
                   
                   
                 TTAAGTTTGATAGCATTTGCCTTTACGCCACCTTCTTCCCCATGGCCCACAACACCG 
               
               
                   
                   
                 CCTCCACGCTTGAGGCCATGCTTAGAAACGACACCAACGACCAGTCCTTTAACGACT 
               
               
                   
                   
                 ATCTCTCCGCCGCCAACATGCTCTACCCTATACCCGCCAACGCTACCAACGTGCCCA 
               
               
                   
                   
                 TATCCATCCCCTCCCGCAACTGGGCGGCTTTCCGCGGCTGGGCCTTCACGCGCCTT 
               
               
                   
                   
                 AAGACTAAGGAAACCCCATCACTGGGCTCGGGCTACGACCCTTATTACACCTACTCT 
               
               
                   
                   
                 GGCTCTATACCCTACCTAGATGGAACCTTTTACCTCAACCACACCTTTAAGAAGGTG 
               
               
                   
                   
                 GCCATTACCTTTGACTCTTCTGTCAGCTGGCCTGGCAATGACCGCCTGCTTACCCCC 
               
               
                   
                   
                 AACGAGTTTGAAATTAAGCGCTCAGTTGACGGGGAGGGTTACAACGTTGCCCAGTG 
               
               
                   
                   
                 TAACATGACCAAAGACTGGTTCCTGGTACAAATGCTAGCTAACTACAACATTGGCTA 
               
               
                   
                   
                 CCAGGGCTTCTATATCCCAGAGAGCTACAAGGACCGCATGTACTCCTTCTTTAGAAA 
               
               
                   
                   
                 CTTCCAGCCCATGAGCCGTCAGGTGGTGGATGATACTAAATACAAGGACTACCAACA 
               
               
                   
                   
                 GGTGGGCATCCTACACCAACACAACAACTCTGGATTTGTTGGCTACCTTGCCCCCAC 
               
               
                   
                   
                 CATGCGCGAAGGACAGGCCTACCCTGCTAACTTCCCCTATCCGCTTATAGGCAAGA 
               
               
                   
                   
                 CCGCAGTTGACAGCATTACCCAGAAAAAGTTTCTTTGCGATCGCACCCTTTGGCGCA 
               
               
                   
                   
                 TCCCATTCTCCAGTAACTTTATGTCCATGGGCGCACTCACAGACCTGGGCCAAAACC 
               
               
                   
                   
                 TTCTCTACGCCAACTCCGCCCACGCGCTAGACATGACTTTTGAGGTGGATCCCATGG 
               
               
                   
                   
                 ACGAGCCCACCCTTCTTTATGTTTTGTTTGAAGTCTTTGACGTGGTCCGTGTGCACC 
               
               
                   
                   
                 GGCCGCACCGCGGCGTCATCGAAACCGTGTACCTGCGCACGCCCTTCTCGGCCGG 
               
               
                   
                   
                 CAACGCCACAACATAAAGAAGCAAGCAACATCAACAACAGCTGCCGCCATGGGCTC 
               
               
                   
                   
                 CAGTGAGCAGGAACTGAAAGCCATTGTCAAAGATCTTGGTTGTGGGCCATATTTTTT 
               
               
                   
                   
                 GGGCACCTATGACAAGCGCTTTCCAGGCTTTGTTTCTCCACACAAGCTCGCCTGCG 
               
               
                   
                   
                 CCATAGTCAATACGGCCGGTCGCGAGACTGGGGGCGTACACTGGATGGCCTTTGCC 
               
               
                   
                   
                 TGGAACCCGCACTCAAAAACATGCTACCTCTTTGAGCCCTTTGGCTTTTCTGACCAG 
               
               
                   
                   
                 CGACTCAAGCAGGTTTACCAGTTTGAGTACGAGTCACTCCTGCGCCGTAGCGCCATT 
               
               
                   
                   
                 GCTTCTTCCCCCGACCGCTGTATAACGCTGGAAAAGTCCACCCAAAGCGTACAGGG 
               
               
                   
                   
                 GCCCAACTCGGCCGCCTGTGGACTATTCTGCTGCATGTTTCTCCACGCCTTTGCCAA 
               
               
                   
                   
                 CTGGCCCCAAACTCCCATGGATCACAACCCCACCATGAACCTTATTACCGGGGTACC 
               
               
                   
                   
                 CAACTCCATGCTCAACAGTCCCCAGGTACAGCCCACCCTGCGTCGCAACCAGGAAC 
               
               
                   
                   
                 AGCTCTACAGCTTCCTGGAGCGCCACTCGCCCTACTTCCGCAGCCACAGTGCGCAG 
               
               
                   
                   
                 ATTAGGAGCGCCACTTCTTTTTGTCACTTGAAAAACATGTAAAAATAATGTACTAGAG 
               
               
                   
                   
                 ACACTTTCAATAAAGGCAAATGCTTTTATTTGTACACTCTCGGGTGATTATTTACCCC 
               
               
                   
                   
                 CACCCTTGCCGTCTGCGCCGTTTAAAAATCAAAGGGGTTCTGCCGCGCATCGCTAT 
               
               
                   
                   
                 GCGCCACTGGCAGGGACACGTTGCGATACTGGTGTTTAGTGCTCCACTTAAACTCA 
               
               
                   
                   
                 GGCACAACCATCCGCGGCAGCTCGGTGAAGTTTTCACTCCACAGGCTGCGCACCAT 
               
               
                   
                   
                 CACCAACGCGTTTAGCAGGTCGGGCGCCGATATCTTGAAGTCGCAGTTGGGGCCTC 
               
               
                   
                   
                 CGCCCTGCGCGCGCGAGTTGCGATACACAGGGTTGCAGCACTGGAACACTATCAGC 
               
               
                   
                   
                 GCCGGGTGGTGCACGCTGGCCAGCACGCTCTTGTCGGAGATCAGATCCGCGTCCA 
               
               
                   
                   
                 GGTCCTCCGCGTTGCTCAGGGCGAACGGAGTCAACTTTGGTAGCTGCCTTCCCAAA 
               
               
                   
                   
                 AAGGGCGCGTGCCCAGGCTTTGAGTTGCACTCGCACCGTAGTGGCATCAAAAGGTG 
               
               
                   
                   
                 ACCGTGCCCGGTCTGGGCGTTAGGATACAGCGCCTGCATAAAAGCCTTGATCTGCT 
               
               
                   
                   
                 TAAAAGCCACCTGAGCCTTTGCGCCTTCAGAGAAGAACATGCCGCAAGACTTGCCG 
               
               
                   
                   
                 GAAAACTGATTGGCCGGACAGGCCGCGTCGTGCACGCAGCACCTTGCGTCGGTGTT 
               
               
                   
                   
                 GGAGATCTGCACCACATTTCGGCCCCACCGGTTCTTCACGATCTTGGCCTTGCTAGA 
               
               
                   
                   
                 CTGCTCCTTCAGCGCGCGCTGCCCGTTTTCGCTCGTCACATCCATTTCAATCACGTG 
               
               
                   
                   
                 CTCCTTATTTATCATAATGCTTCCGTGTAGACACTTAAGCTCGCCTTCGATCTCAGCG 
               
               
                   
                   
                 CAGCGGTGCAGCCACAACGCGCAGCCCGTGGGCTCGTGATGCTTGTAGGTCACCT 
               
               
                   
                   
                 CTGCAAACGACTGCAGGTACGCCTGCAGGAATCGCCCCATCATCGTCACAAAGGTC 
               
               
                   
                   
                 TTGTTGCTGGTGAAGGTCAGCTGCAACCCGCGGTGCTCCTCGTTCAGCCAGGTCTT 
               
               
                   
                   
                 GCATACGGCCGCCAGAGCTTCCACTTGGTCAGGCAGTAGTTTGAAGTTCGCCTTTA 
               
               
                   
                   
                 GATCGTTATCCACGTGGTACTTGTCCATCAGCGCGCGCGCAGCCTCCATGCCCTTC 
               
               
                   
                   
                 TCCCACGCAGACACGATCGGCACACTCAGCGGGTTCATCACCGTAATTTCACTTTCC 
               
               
                   
                   
                 GCTTCGCTGGGCTCTTCCTCTTCCTCTTGCGTCCGCATACCACGCGCCACTGGGTC 
               
               
                   
                   
                 GTCTTCATTCAGCCGCCGCACTGTGCGCTTACCTCCTTTGCCATGCTTGATTAGCAC 
               
               
                   
                   
                 CGGTGGGTTGCTGAAACCCACCATTTGTAGCGCCACATCTTCTCTTTCTTCCTCGCT 
               
               
                   
                   
                 GTCCACGATTACCTCTGGTGATGGCGGGCGCTCGGGCTTGGGAGAAGGGCGCTTC 
               
               
                   
                   
                 TTTTTCTTCTTGGGCGCAATGGCCAAATCCGCCGCCGAGGTCGATGGCCGCGGGCT 
               
               
                   
                   
                 GGGTGTGCGCGGCACCAGCGCGTCTTGTGATGAGTCTTCCTCGTCCTCGGACTCGA 
               
               
                   
                   
                 TACGCCGCCTCATCCGCTTTTTTGGGGGCGCCCGGGGAGGCGGCGGCGACGGGG 
               
               
                   
                   
                 ACGGGGACGACACGTCCTCCATGGTTGGGGGACGTCGCGCCGCACCGCGTCCGCG 
               
               
                   
                   
                 CTCGGGGGTGGTTTCGCGCTGCTCCTCTTCCCGACTGGCCATTTCCTTCTCCTATAG 
               
               
                   
                   
                 GCAGAAAAAGATCATGGAGTCAGTCGAGAAGAAGGACAGCCTAACCGCCCCCTCTG 
               
               
                   
                   
                 AGTTCGCCACCACCGCCTCCACCGATGCCGCCAACGCGCCTACCACCTTCCCCGTC 
               
               
                   
                   
                 GAGGCACCCCCGCTTGAGGAGGAGGAAGTGATTATCGAGCAGGACCCAGGTTTTGT 
               
               
                   
                   
                 AAGCGAAGACGACGAGGACCGCTCAGTACCAACAGAGGATAAAAAGCAAGACCAGG 
               
               
                   
                   
                 ACAACGCAGAGGCAAACGAGGAACAAGTCGGGCGGGGGGACGAAAGGCATGGCGA 
               
               
                   
                   
                 CTACCTAGATGTGGGAGACGACGTGCTGTTGAAGCATCTGCAGCGCCAGTGCGCCA 
               
               
                   
                   
                 TTATCTGCGACGCGTTGCAAGAGCGCAGCGATGTGCCCCTCGCCATAGCGGATGTC 
               
               
                   
                   
                 AGCCTTGCCTACGAACGCCACCTATTCTCACCGCGCGTACCCCCCAAACGCCAAGA 
               
               
                   
                   
                 AAACGGCACATGCGAGCCCAACCCGCGCCTCAACTTCTACCCCGTATTTGCCGTGC 
               
               
                   
                   
                 CAGAGGTGCTTGCCACCTATCACATCTTTTTCCAAAACTGCAAGATACCCCTATCCTG 
               
               
                   
                   
                 CCGTGCCAACCGCAGCCGAGCGGACAAGCAGCTGGCCTTGCGGCAGGGCGCTGTC 
               
               
                   
                   
                 ATACCTGATATCGCCTCGCTCAACGAAGTGCCAAAAATCTTTGAGGGTCTTGGACGC 
               
               
                   
                   
                 GACGAGAAGCGCGCGGCAAACGCTCTGCAACAGGAAAACAGCGAAAATGAAAGTCA 
               
               
                   
                   
                 CTCTGGAGTGTTGGTGGAACTCGAGGGTGACAACGCGCGCCTAGCCGTACTAAAAC 
               
               
                   
                   
                 GCAGCATCGAGGTCACCCACTTTGCCTACCCGGCACTTAACCTACCCCCCAAGGTC 
               
               
                   
                   
                 ATGAGCACAGTCATGAGTGAGCTGATCGTGCGCCGTGCGCAGCCCCTGGAGAGGG 
               
               
                   
                   
                 ATGCAAATTTGCAAGAACAAACAGAGGAGGGCCTACCCGCAGTTGGCGACGAGCAG 
               
               
                   
                   
                 CTAGCGCGCTGGCTTCAAACGCGCGAGCCTGCCGACTTGGAGGAGCGACGCAAAC 
               
               
                   
                   
                 TAATGATGGCCGCAGTGCTCGTTACCGTGGAGCTTGAGTGCATGCAGCGGTTCTTT 
               
               
                   
                   
                 GCTGACCCGGAGATGCAGCGCAAGCTAGAGGAAACATTGCACTACACCTTTCGACA 
               
               
                   
                   
                 GGGCTACGTACGCCAGGCCTGCAAGATCTCCAACGTGGAGCTCTGCAACCTGGTCT 
               
               
                   
                   
                 CCTACCTTGGAATTTTGCACGAAAACCGCCTTGGGCAAAACGTGCTTCATTCCACGC 
               
               
                   
                   
                 TCAAGGGCGAGGCGCGCCGCGACTACGTCCGCGACTGCGTTTACTTATTTCTATGC 
               
               
                   
                   
                 TACACCTGGCAGACGGCCATGGGCGTTTGGCAGCAGTGCTTGGAGGAGTGCAACCT 
               
               
                   
                   
                 CAAGGAGCTGCAGAAACTGCTAAAGCAAAACTTGAAGGACCTATGGACGGCCTTCA 
               
               
                   
                   
                 ACGAGCGCTCCGTGGCCGCGCACCTGGCGGACATCATTTTCCCCGAACGCCTGCTT 
               
               
                   
                   
                 AAAACCCTGCAACAGGGTCTGCCAGACTTCACCAGTCAAAGCATGTTGCAGAACTTT 
               
               
                   
                   
                 AGGAACTTTATCCTAGAGCGCTCAGGAATCTTGCCCGCCACCTGCTGTGCACTTCCT 
               
               
                   
                   
                 AGCGACTTTGTGCCCATTAAGTACCGCGAATGCCCTCCGCCGCTTTGGGGCCACTG 
               
               
                   
                   
                 CTACCTTCTGCAGCTAGCCAACTACCTTGCCTACCACTCTGACATAATGGAAGACGT 
               
               
                   
                   
                 GAGCGGTGACGGTCTACTGGAGTGTCACTGTCGCTGCAACCTATGCACCCCGCACC 
               
               
                   
                   
                 GCTCCCTGGTTTGCAATTCGCAGCTGCTTAACGAAAGTCAAATTATCGGTACCTTTG 
               
               
                   
                   
                 AGCTGCAGGGTCCCTCGCCTGACGAAAAGTCCGCGGCTCCGGGGTTGAAACTCACT 
               
               
                   
                   
                 CCGGGGCTGTGGACGTCGGCTTACCTTCGCAAATTTGTACCTGAGGACTACCACGC 
               
               
                   
                   
                 CCACGAGATTAGGTTCTACGAAGACCAATCCCGCCCGCCAAATGCGGAGCTTACCG 
               
               
                   
                   
                 CCTGCGTCATTACCCAGGGCCACATTCTTGGCCAATTGCAAGCCATCAACAAAGCCC 
               
               
                   
                   
                 GCCAAGAGTTTCTGCTACGAAAGGGACGGGGGGTTTACTTGGACCCCCAGTCCGGC 
               
               
                   
                   
                 GAGGAGCTCAACCCAATCCCCCCGCCGCCGCAGCCCTATCAGCAGCAGCCGCGGG 
               
               
                   
                   
                 CCCTTGCTTCCCAGGATGGCACCCAAAAAGAAGCTGCAGCTGCCGCCGCCACCCAC 
               
               
                   
                   
                 GGACGAGGAGGAATACTGGGACAGTCAGGCAGAGGAGGTTTTGGACGAGGAGGAG 
               
               
                   
                   
                 GAGGACATGATGGAAGACTGGGAGAGCCTAGACGAGGAAGCTTCCGAGGTCGAAG 
               
               
                   
                   
                 AGGTGTCAGACGAAACACCGTCACCCTCGGTCGCATTCCCCTCGCCGGCGCCCCA 
               
               
                   
                   
                 GAAATCGGCAACCGGTTCCAGCATGGCTACAACCTCCGCTCCTCAGGCGCCGCCG 
               
               
                   
                   
                 GCACTGCCCGTTCGCCGACCCAACCGTAGATGGGACACCACTGGAACCAGGGCCG 
               
               
                   
                   
                 GTAAGTCCAAGCAGCCGCCGCCGTTAGCCCAAGAGCAACAACAGCGCCAAGGCTAC 
               
               
                   
                   
                 CGCTCATGGCGCGGGCACAAGAACGCCATAGTTGCTTGCTTGCAAGACTGTGGGGG 
               
               
                   
                   
                 CAACATCTCCTTCGCCCGCCGCTTTCTTCTCTACCATCACGGCGTGGCCTTCCCCCG 
               
               
                   
                   
                 TAACATCCTGCATTACTACCGTCATCTCTACAGCCCATACTGCACCGGCGGCAGCGG 
               
               
                   
                   
                 CAGCGGCAGCAACAGCAGCGGCCACACAGAAGCAAAGGCGACCGGATAGCAAGAC 
               
               
                   
                   
                 TCTGACAAAGCCCAAGAAATCCACAGCGGCGGCAGCAGCAGGAGGAGGAGCGCTG 
               
               
                   
                   
                 CGTCTGGCGCCCAACGAACCCGTATCGACCCGCGAGCTTAGAAACAGGATTTTTCC 
               
               
                   
                   
                 CACTCTGTATGCTATATTTCAACAGAGCAGGGGCCAAGAACAAGAGCTGAAAATAAA 
               
               
                   
                   
                 AAACAGGTCTCTGCGATCCCTCACCCGCAGCTGCCTGTATCACAAAAGCGAAGATCA 
               
               
                   
                   
                 GCTTCGGCGCACGCTGGAAGACGCGGAGGCTCTCTTCAGTAAATACTGCGCGCTGA 
               
               
                   
                   
                 CTCTTAAGGACTAGTTTCGCGCCCTTTCTCAAATTTAAGCGCGAAAACTACGTCATCT 
               
               
                   
                   
                 CCAGCGGCCACACCCGGCGCCAGCACCTGTCGTCAGCGCCATTATGAGCAAGGAA 
               
               
                   
                   
                 ATTCCCACGCCCTACATGTGGAGTTACCAGCCACAAATGGGACTTGCGGCTGGAGC 
               
               
                   
                   
                 TGCCCAAGACTACTCAACCCGAATAAACTACATGAGCGCGGGACCCCACATGATATC 
               
               
                   
                   
                 CCGGGTCAACGGAATCCGCGCCCACCGAAACCGAATTCTCTTGGAACAGGCGGCTA 
               
               
                   
                   
                 TTACCACCACACCTCGTAATAACCTTAATCCCCGTAGTTGGCCCGCTGCCCTGGTGT 
               
               
                   
                   
                 ACCAGGAAAGTCCCGCTCCCACCACTGTGGTACTTCCCAGAGACGCCCAGGCCGAA 
               
               
                   
                   
                 GTTCAGATGACTAACTCAGGGGCGCAGCTTGCGGGCGGCTTTCGTCACAGGGTGC 
               
               
                   
                   
                 GGTCGCCCGGGCAGGGTATAACTCACCTGACAATCAGAGGGCGAGGTATTCAGCTC 
               
               
                   
                   
                 AACGACGAGTCGGTGAGCTCCTCGCTTGGTCTCCGTCCGGACGGGACATTTCAGAT 
               
               
                   
                   
                 CGGCGGCGCCGGCCGCTCTTCATTCACGCCTCGTCAGGCAATCCTAACTCTGCAGA 
               
               
                   
                   
                 CCTCGTCCTCTGAGCCGCGCTCTGGAGGCATTGGAACTCTGCAATTTATTGAGGAGT 
               
               
                   
                   
                 TTGTGCCATCGGTCTACTTTAACCCCTTCTCGGGACCTCCCGGCCACTATCCGGATC 
               
               
                   
                   
                 AATTTATTCCTAACTTTGACGCGGTAAAGGACTCGGCGGATGGCTACGACTGAATGT 
               
               
                   
                   
                 TAAGTGGAGAGGCAGAGCAACTGCGCCTGAAACACCTGGTCCACTGTCGCCGCCAC 
               
               
                   
                   
                 AAGTGCTTTGCCCGCGACTCCGGTGAGTTTTGCTACTTTGAATTGCCCGAGGATCAT 
               
               
                   
                   
                 ATCGAGGGCCCGGCGCACGGCGTCCGGCTTACCGCCCAGGGAGAGCTTGCCCGTA 
               
               
                   
                   
                 GCCTGATTCGGGAGTTTACCCAGCGCCCCCTGCTAGTTGAGCGGGACAGGGGACC 
               
               
                   
                   
                 CTGTGTTCTCACTGTGATTTGCAACTGTCCTAACCCTGGATTACATCAAGATCTTTGT 
               
               
                   
                   
                 TGCCATCTCTGTGCTGAGTATAATAAATACAGAAATTAAAATATACTGGGGCTCCTAT 
               
               
                   
                   
                 CGCCATCCTGTAAACGCCACCGTCTTCACCCGCCCAAGCAAACCAAGGCGAACCTT 
               
               
                   
                   
                 ACCTGGTACTTTTAACATCTCTCCCTCTGTGATTTACAACAGTTTCAACCCAGACGGA 
               
               
                   
                   
                 GTGAGTCTACGAGAGAACCTCTCCGAGCTCAGCTACTCCATCAGAAAAAACACCACC 
               
               
                   
                   
                 CTCCTTACCTGCCGGGAACGTACGACCTAGGGATAACAGGGTAATAAGCAATTGACT 
               
               
                   
                   
                 CTATGTGGGATATGCTCCAGCGCTACAACCTTGAAGTCAGGCTTCCTGGATGTCAGC 
               
               
                   
                   
                 ATCTGACTTTGGCCAGCACCTGTCCCGCGGATTTGTTCCAGTCCAACTACAGCGACC 
               
               
                   
                   
                 CACCCTAACAGAGATGACCAACACAACCAACGCGGCCGCCGCTACCGGACTTACAT 
               
               
                   
                   
                 CTACCACAAATACACCCCAAGTTTCTGCCTTTGTCAATAACTGGGATAACTTGGGCAT 
               
               
                   
                   
                 GTGGTGGTTCTCCATAGCGCTTATGTTTGTATGCCTTATTATTATGTGGCTCATCTGC 
               
               
                   
                   
                 TGCCTAAAGCGCAAACGCGCCCGACCACCCATCTATAGTCCCATCATTGTGCTACAC 
               
               
                   
                   
                 CCAAACAATGATGGAATCCATAGATTGGACGGACTGAAACACATGTTCTTTTCTCTTA 
               
               
                   
                   
                 CAGTATGATTAAATGAGACATGATTCCTCGAGTTTTTATATTACTGACCCTTGTTGCG 
               
               
                   
                   
                 CTTTTTTGTGCGTGCTCCACATTGGCTGCGGTTTCTCACATCGAAGTAGACTGCATT 
               
               
                   
                   
                 CCAGCCTTCACAGTCTATTTGCTTTACGGATTTGTCACCCTCACGCTCATCTGCAGC 
               
               
                   
                   
                 CTCATCACTGTGGTCATCGCCTTTATCCAGTGCATTGACTGGGTCTGTGTGCGCTTT 
               
               
                   
                   
                 GCATATCTCAGACACCATCCCCAGTACAGGGACAGGACTATAGCTGAGCTTCTTAGA 
               
               
                   
                   
                 ATTCTTTAATTATGAAATTTACTGTGACTTTTCTGCTGATTATTTGCACCCTATCTGCG 
               
               
                   
                   
                 TTTTGTTCCCCGACCTCCAAGCCTCAAAGACATATATCATGCAGATTCACTCGTATAT 
               
               
                   
                   
                 GGAATATTCCAAGTTGCTACAATGAAAAAAGCGATCTTTCCGAAGCCTGGTTATATGC 
               
               
                   
                   
                 AATCATCTCTGTTATGGTGTTCTGCAGTACCATCTTAGCCCTAGCTATATATCCCTAC 
               
               
                   
                   
                 CTTGACATTGGCTGGAAACGAATAGATGCCATGAACCACCCAACTTTCCCCGCGCCC 
               
               
                   
                   
                 GCTATGCTTCCACTGCAACAAGTTGTTGCCGGCGGCTTTGTCCCAGCCAATCAGCCT 
               
               
                   
                   
                 CGCCCCACTTCTCCCACCCCCACTGAAATCAGCTACTTTAATCTAACAGGAGGAGAT 
               
               
                   
                   
                 GACTGACACCCTAGATCTAGAAATGGACGGAATTATTACAGAGCAGCGCCTGCTAGA 
               
               
                   
                   
                 AAGACGCAGGGCAGCGGCCGAGCAACAGCGCATGAATCAAGAGCTCCAAGACATG 
               
               
                   
                   
                 GTTAACTTGCACCAGTGCAAAAGGGGTATCTTTTGTCTGGTAAAGCAGGCCAAAGTC 
               
               
                   
                   
                 ACCTACGACAGTAATACCACCGGACACCGCCTTAGCTACAAGTTGCCAACCAAGCGT 
               
               
                   
                   
                 CAGAAATTGGTGGTCATGGTGGGAGAAAAGCCCATTACCATAACTCAGCACTCGGTA 
               
               
                   
                   
                 GAAACCGAAGGCTGCATTCACTCACCTTGTCAAGGACCTGAGGATCTCTGCACCCTT 
               
               
                   
                   
                 ATTAAGACCCTGTGCGGTCTCAAAGATCTTATTCCCTTTAACTAATAAAAAAAAATAAT 
               
               
                   
                   
                 AAAGCATCACTTACTTAAAATCAGTTAGCAAATTTCTGTCCAGTTTATTCAGCAGCAC 
               
               
                   
                   
                 CTCCTTGCCCTCCTCCCAGCTCTGGTATTGCAGCTTCCTCCTGGCTGCAAACTTTCT 
               
               
                   
                   
                 CCACAATCTAAATGGAATGTCAGTTTCCTCCTGTTCCTGTCCATCCGCACCCACTATC 
               
               
                   
                   
                 TTCATGTTGTTGCAGATGAAGCGCGCAAGACCGTCTGAAGATACCTTCAACCCCGTG 
               
               
                   
                   
                 TATCCATATGACACGGAAACCGGTCCTCCAACTGTGCCTTTTCTTACTCCTCCCTTTG 
               
               
                   
                   
                 TATCCCCCAATGGGTTTCAAGAGAGTCCCCCTGGGGTACTCTCTTTGCGCCTATCCG 
               
               
                   
                   
                 AACCTCTAGTTACCTCCAATGGCATGCTTGCGCTCAAAATGGGCAACGGCCTCTCTC 
               
               
                   
                   
                 TGGACGAGGCCGGCAACCTTACCTCCCAAAATGTAACCACTGTGAGCCCACCTCTC 
               
               
                   
                   
                 AAAAAAACCAAGTCAAACATAAACCTGGAAATATCTGCACCCCTCACAGTTACCTCAG 
               
               
                   
                   
                 AAGCCCTAACTGTGGCTGCCGCCGCACCTCTAATGGTCGCGGGCAACACACTCACC 
               
               
                   
                   
                 ATGCAATCACAGGCCCCGCTAACCGTGCACGACTCCAAACTTAGCATTGCCACCCAA 
               
               
                   
                   
                 GGACCCCTCACAGTGTCAGAAGGAAAGCTAGCCCTGCAAACATCAGGCCCCCTCAC 
               
               
                   
                   
                 CACCACCGATAGCAGTACCCTTACTATCACTGCCTCACCCCCTCTAACTACTGCCAC 
               
               
                   
                   
                 TGGTAGCTTGGGCATTGACTTGAAAGAGCCCATTTATACACAAAATGGAAAACTAGG 
               
               
                   
                   
                 ACTAAAGTACGGGGCTCCTTTGCATGTAACAGACGACCTAAACACTTTGACCGTAGC 
               
               
                   
                   
                 AACTGGTCCAGGTGTGACTATTAATAATACTTCCTTGCAAACTAAAGTTACTGGAGCC 
               
               
                   
                   
                 TTGGGTTTTGATTCACAAGGCAATATGCAACTTAATGTAGCAGGAGGACTAAGGATT 
               
               
                   
                   
                 GATTCTCAAAACAGACGCCTTATACTTGATGTTAGTTATCCGTTTGATGCTCAAAACC 
               
               
                   
                   
                 AACTAAATCTAAGACTAGGACAGGGCCCTCTTTTTATAAACTCAGCCCACAACTTGGA 
               
               
                   
                   
                 TATTAACTACAACAAAGGCCTTTACTTGTTTACAGCTTCAAACAATTCCAAAAAGCTTG 
               
               
                   
                   
                 AGGTTAACCTAAGCACTGCCAAGGGGTTGATGTTTGACGCTACAGCCATAGCCATTA 
               
               
                   
                   
                 ATGCAGGAGATGGGCTTGAATTTGGTTCACCTAATGCACCAAACACAAATCCCCTCA 
               
               
                   
                   
                 AAACAAAAATTGGCCATGGCCTAGAATTTGATTCAAACAAGGCTATGGTTCCTAAACT 
               
               
                   
                   
                 AGGAACTGGCCTTAGTTTTGACAGCACAGGTGCCATTACAGTAGGAAACAAAAATAA 
               
               
                   
                   
                 TGATAAGCTAACCCTATGGACAGGTCCAAAACCAGAAGCCAACTGCATAATTGAATA 
               
               
                   
                   
                 CGGGAAACAAAACCCAGATAGCAAACTAACTTTAATCCTTGTAAAAAATGGAGGAATT 
               
               
                   
                   
                 GTTAATGGATATGTAACGCTAATGGGAGCCTCAGACTACGTTAACACCTTATTTAAAA 
               
               
                   
                   
                 ACAAAAATGTCTCCATTAATGTAGAACTATACTTTGATGCCACTGGTCATATATTACCA 
               
               
                   
                   
                 GACTCATCTTCTCTTAAAACAGATCTAGAACTAAAATACAAGCAAACCGCTGACTTTA 
               
               
                   
                   
                 GTGCAAGAGGTTTTATGCCAAGTACTACAGCGTATCCATTTGTCCTTCCTAATGCGG 
               
               
                   
                   
                 GAACACATAATGAAAATTATATTTTTGGTCAATGCTACTACAAAGCAAGCGATGGTGC 
               
               
                   
                   
                 CCTTTTTCCGTTGGAAGTTACTGTTATGCTTAATAAACGCCTGCCAGATAGTCGCACA 
               
               
                   
                   
                 TCCTATGTTATGACTTTTTTATGGTCCTTGAATGCTGGTCTAGCTCCAGAAACTACTC 
               
               
                   
                   
                 AGGCAACCCTCATAACCTCCCCATTTACCTTTTCCTATATTAGAGAAGATGACTAATA 
               
               
                   
                   
                 AACTCTAAAGAATCGTTTGTGTTATGTTTCAACGTGTTTATTTTTCAATTGCAGAAAAT 
               
               
                   
                   
                 TTCAAGTCATTTTTCATTCAGTAGTATAGCCCCACCACCACATAGCTTATACAGATCA 
               
               
                   
                   
                 CCGTACCTTAATCAAACTCACAGAACCCTAGTATTCAACCTGCCACCTCCCTCCCAA 
               
               
                   
                   
                 CACACAGAGTACACAGTCCTTTCTCCCCGGCTGGCCTTAAAAAGCATCATATCATGG 
               
               
                   
                   
                 GTAACAGACATATTCTTAGGTGTTATATTCCACACGGTTTCCTGTCGAGCCAAACGCT 
               
               
                   
                   
                 CATCAGTGATATTAATAAACTCCCCGGGCAGCTCACTTAAGTTCATGTCGCTGTCCA 
               
               
                   
                   
                 GCTGCTGAGCCACAGGCTGCTGTCCAACTTGCGGTTGCTTAACGGGCGGCGAAGG 
               
               
                   
                   
                 AGAAGTCCACGCCTACATGGGGGTAGAGTCATAATCGTGCATCAGGATAGGGCGGT 
               
               
                   
                   
                 GGTGCTGCAGCAGCGCGCGAATAAACTGCTGCCGCCGCCGCTCCGTCCTGCAGGA 
               
               
                   
                   
                 ATACAACATGGCAGTGGTCTCCTCAGCGATGATTCGCACCGCCCGCAGCATAAGGC 
               
               
                   
                   
                 GCCTTGTCCTCCGGGCACAGCAGCGCACCCTGATCTCACTTAAATCAGCACAGTAA 
               
               
                   
                   
                 CTGCAGCACAGCACCACAATATTGTTCAAAATCCCACAGTGCAAGGCGCTGTATCCA 
               
               
                   
                   
                 AAGCTCATGGCGGGGACCACAGAACCCACGTGGCCATCATACCACAAGCGCAGGTA 
               
               
                   
                   
                 GATTAAGTGGCGACCCCTCATAAACACGCTGGACATAAACATTACCTCTTTTGGCAT 
               
               
                   
                   
                 GTTGTAATTCACCACCTCCCGGTACCATATAAACCTCTGATTAAACATGGCGCCATC 
               
               
                   
                   
                 CACCACCATCCTAAACCAGCTGGCCAAAACCTGCCCGCCGGCTATACACTGCAGGG 
               
               
                   
                   
                 AACCGGGACTGGAACAATGACAGTGGAGAGCCCAGGACTCGTAACCATGGATCATC 
               
               
                   
                   
                 ATGCTCGTCATGATATCAATGTTGGCACAACACAGGCACACGTGCATACACTTCCTC 
               
               
                   
                   
                 AGGATTACAAGCTCCTCCCGCGTTAGAACCATATCCCAGGGAACAACCCATTCCTGA 
               
               
                   
                   
                 ATCAGCGTAAATCCCACACTGCAGGGAAGACCTCGCACGTAACTCACGTTGTGCATT 
               
               
                   
                   
                 GTCAAAGTGTTACATTCGGGCAGCAGCGGATGATCCTCCAGTATGGTAGCGCGGGT 
               
               
                   
                   
                 TTCTGTCTCAAAAGGAGGTAGACGATCCCTACTGTACGGAGTGCGCCGAGACAACC 
               
               
                   
                   
                 GAGATCGTGTTGGTCGTAGTGTCATGCCAAATGGAACGCCGGACGTAGTCATATTTC 
               
               
                   
                   
                 CTGAAGCAAAACCAGGTGCGGGCGTGACAAACAGATCTGCGTCTCCGGTCTCGCCG 
               
               
                   
                   
                 CTTAGATCGCTCTGTGTAGTAGTTGTAGTATATCCACTCTCTCAAAGCATCCAGGCG 
               
               
                   
                   
                 CCCCCTGGCTTCGGGTTCTATGTAAACTCCTTCATGCGCCGCTGCCCTGATAACATC 
               
               
                   
                   
                 CACCACCGCAGAATAAGCCACACCCAGCCAACCTACACATTCGTTCTGCGAGTCACA 
               
               
                   
                   
                 CACGGGAGGAGCGGGAAGAGCTGGAAGAACCATGTTTTTTTTTTTATTCCAAAAGAT 
               
               
                   
                   
                 TATCCAAAACCTCAAAATGAAGATCTATTAAGTGAACGCGCTCCCCTCCGGTGGCGT 
               
               
                   
                   
                 GGTCAAACTCTACAGCCAAAGAACAGATAATGGCATTTGTAAGATGTTGCACAATGG 
               
               
                   
                   
                 CTTCCAAAAGGCAAACGGCCCTCACGTCCAAGTGGACGTAAAGGCTAAACCCTTCA 
               
               
                   
                   
                 GGGTGAATCTCCTCTATAAACATTCCAGCACCTTCAACCATGCCCAAATAATTCTCAT 
               
               
                   
                   
                 CTCGCCACCTTCTCAATATATCTCTAAGCAAATCCCGAATATTAAGTCCGGCCATTGT 
               
               
                   
                   
                 AAAAATCTGCTCCAGAGCGCCCTCCACCTTCAGCCTCAAGCAGCGAATCATGATTGC 
               
               
                   
                   
                 AAAAATTCAGGTTCCTCACAGACCTGTATAAGATTCAAAAGCGGAACATTAACAAAAA 
               
               
                   
                   
                 TACCGCGATCCCGTAGGTCCCTTCGCAGGGCCAGCTGAACATAATCGTGCAGGTCT 
               
               
                   
                   
                 GCACGGACCAGCGCGGCCACTTCCCCGCCAGGAACCTTGACAAAAGAACCCACACT 
               
               
                   
                   
                 GATTATGACACGCATACTCGGAGCTATGCTAACCAGCGTAGCCCCGATGTAAGCTTT 
               
               
                   
                   
                 GTTGCATGGGCGGCGATATAAAATGCAAGGTGCTGCTCAAAAAATCAGGCAAAGCC 
               
               
                   
                   
                 TCGCGCAAAAAAGAAAGCACATCGTAGTCATGCTCATGCAGATAAAGGCAGGTAAGC 
               
               
                   
                   
                 TCCGGAACCACCACAGAAAAAGACACCATTTTTCTCTCAAACATGTCTGCGGGTTTC 
               
               
                   
                   
                 TGCATAAACACAAAATAAAATAACAAAAAAACATTTAAACATTAGAAGCCTGTCTTACA 
               
               
                   
                   
                 ACAGGAAAAACAACCCTTATAAGCATAAGACGGACTACGGCCATGCCGGCGTGACC 
               
               
                   
                   
                 GTAAAAAAACTGGTCACCGTGATTAAAAAGCACCACCGACAGCTCCTCGGTCATGTC 
               
               
                   
                   
                 CGGAGTCATAATGTAAGACTCGGTAAACACATCAGGTTGATTCATCGGTCAGTGCTA 
               
               
                   
                   
                 AAAAGCGACCGAAATAGCCCGGGGGAATACATACCCGCAGGCGTAGAGACAACATT 
               
               
                   
                   
                 ACAGCCCCCATAGGAGGTATAACAAAATTAATAGGAGAGAAAAACACATAAACACCT 
               
               
                   
                   
                 GAAAAACCCTCCTGCCTAGGCAAAATAGCACCCTCCCGCTCCAGAACAACATACAGC 
               
               
                   
                   
                 GCTTCACAGCGGCAGCCTAACAGTCAGCCTTACCAGTAAAAAAGAAAACCTATTAAA 
               
               
                   
                   
                 AAAACACCACTCGACACGGCACCAGCTCAATCAGTCACAGTGTAAAAAAGGGCCAA 
               
               
                   
                   
                 GTGCAGAGCGAGTATATATAGGACTAAAAAATGACGTAACGGTTAAAGTCCACAAAA 
               
               
                   
                   
                 AACACCCAGAAAACCGCACGCGAACCTACGCCCAGAAACGAAAGCCAAAAAACCCA 
               
               
                   
                   
                 CAACTTCCTCAAATCGTCACTTCCGTTTTCCCACGTTACGTAACTTCCCATTTTAAGA 
               
               
                   
                   
                 AAACTACAATTCCCAACACATACAAGTTACTCCGCCCTAAAACCTACGTCACCCGCC 
               
               
                   
                   
                 CCGTTCCCACGCCCCGCGCCACGTCACAAACTCCACCCCCTCATTATCATATTGGCT 
               
               
                   
                   
                 TCAATCCAAAATAAGGTATATTATTGATGATGTTAAT 
               
               
                   
               
               
                 127 
                 ICOSTAT 
                 TAACATCATCAATTATACCTTCCATTTTGGATTGAAGCCAATATGATAATGAGGGGGT 
               
               
                   
                   
                 GGAGTTTGTGACGTGGCGCGGGGCGTGGGAACGGGGCGGGTGACGTAGTAGTGT 
               
               
                   
                   
                 GGCGGAAGTGTGATGTTGCAAGTGTGGCGGAACACATGTAAGCGACGGATGTGGCA 
               
               
                   
                   
                 AAAGTGACGTTTTTGGTGTGCGCCGGTGTACACAGGAAGTGACAATTTTCGCGCGG 
               
               
                   
                   
                 TTTTAGGCGGATGTTGTAGTAAATTTGGGCGTAACCGAGTAAGATTTGGCCATTTTC 
               
               
                   
                   
                 GCGGGAAAACTGAATAAGAGGAAGTGAAATCTGAATAATTTTGTGTTACTCATAGCG 
               
               
                   
                   
                 CGTAATATTTGTCTAGGGCCGCGGGGACTTTGACCGTTTACGTGGAGACTCGCCCA 
               
               
                   
                   
                 GGTGTTTTTCTCAGGTGTTTTCCGCGTACGTCGGCGGCTCGTGGCTCTTCCGGGAA 
               
               
                   
                   
                 AAGGATTCTCGGAAAGTGGTTCGAGTACGTCGGCGGCTCGTGGCTCTTCCGGGAAA 
               
               
                   
                   
                 AGGATTCTCGGAAAGTGGTTCGAAGTACGTCGACCACAAACCCCGCCCAGCGTCTT 
               
               
                   
                   
                 GTCATTGGCGTCGACGCTGTACGGGGTCAAAGTTGGCGTTTTATTATTATAGTCAGC 
               
               
                   
                   
                 TGACGTGTAGTGTATTTATACCCGGTGAGTTCCTCAAGAGGCCACTCTTGAGTGCCA 
               
               
                   
                   
                 GCGAGTAGAGTTTTCTCCTCCGAGCCGCTCCGACACCGGGACTGAAAATGAGACAT 
               
               
                   
                   
                 ATTATCTGCCACGGAGGTGTTATTACCGAAGAAATGGCCGCCAGTCTTTTGGACCAG 
               
               
                   
                   
                 CTGATCGAAGAGGTACTGGCTGATAATCTTCCACCTCCTAGCCATTTTGAACCACCT 
               
               
                   
                   
                 ACCCTTCACGAACTGTATGATTTAGACGTGACGGCCCCCGAAGATCCCAACGAGGA 
               
               
                   
                   
                 GGCGGTTTCGCAGATTTTTCCCGACTCTGTAATGTTGGCGGTGCAGGAAGGGATTG 
               
               
                   
                   
                 ACTTACTCACTTTTCCGCCGGCGCCCGGTTCTCCGGAGCCGCCTCACCTTTCCCGG 
               
               
                   
                   
                 CAGCCCGAGCAGCCGGAGCAGAGAGCCTTGGGTCCGGTTTCTATGCCAAACCTTGT 
               
               
                   
                   
                 ACCGGAGGTGATCGATCCACCCAGTGACGACGAGGATGAAGAGGGTGAGGAGTTT 
               
               
                   
                   
                 GTGTTAGATTATGTGGAGCACCCCGGGCACGGTTGCAGGTCTTGTCATTATCACCG 
               
               
                   
                   
                 GAGGAATACGGGGGACCCAGATATTATGTGTTCGCTTTGCTATATGAGGACCTGTGG 
               
               
                   
                   
                 CATGTTTGTCTACAGTAAGTGAAAATTATGGGCAGTGGGTGATAGAGTGGTGGGTTT 
               
               
                   
                   
                 GGTGTGGTAATTTTTTTTTTAATTTTTACAGTTTTGTGGTTTAAAGAATTTTGTATTGTG 
               
               
                   
                   
                 ATTTTTTTAAAAGGTCCTGTGTCTGAACCTGAGCCTGAGCCCGAGCCAGAACCGGAG 
               
               
                   
                   
                 CCTGCAAGACCTACCCGCCGTCCTAAAATGGCGCCTGCTATCCTGAGACGCCCGAC 
               
               
                   
                   
                 ATCACCTGTGTCTAGAGAATGCAATAGTAGTACGGATAGCTGTGACTCCGGTCCTTC 
               
               
                   
                   
                 TAACACACCTCCTGAGATACACCCGGTGGTCCCGCTGTGCCCCATTAAACCAGTTGC 
               
               
                   
                   
                 CGTGAGAGTTGGTGGGCGTCGCCAGGCTGTGGAATGTATCGAGGACTTGCTTAACG 
               
               
                   
                   
                 AGCCTGGGCAACCTTTGGACTTGAGCTGTAAACGCCCCAGGCCATAAGGTGTAAAC 
               
               
                   
                   
                 CTGTGATTGCGTGTGTGGTTAACGCCTTTGTTTGCTGAATGAGTTGATGTAAGTTTAA 
               
               
                   
                   
                 TAAAGGGTGAGATAATGTTTAACTTGCATGGCGTGTTAAATGGGGCGGGGCTTAAAG 
               
               
                   
                   
                 GGTATATAATGCGCCGTGGGCTAATCTTGGTTACATCTGACCTCATGGAGGCTTGGG 
               
               
                   
                   
                 AGTGTTTGGAAGATTTTTCTGCTGTGCGTAACTTGCTGGAACAGAGCTCTAACAGTA 
               
               
                   
                   
                 CCTCTTGGTTTTGGAGGTTTCTGTGGGGCTCATCCCAGGCAAAGTTAGTCTGCAGAA 
               
               
                   
                   
                 TTAAGGAGGATTACAAGTGGGAATTTGAAGAGCTTTTGAAATCCTGTGGTGAGCTGT 
               
               
                   
                   
                 TTGATTCTTTGAATCTGGGTCACCAGGCGCTTTTCCAAGAGAAGGTCATCAAGACTTT 
               
               
                   
                   
                 GGATTTTTCCACACCGGGGCGCGCTGCGGCTGCTGTTGCTTTTTTGAGTTTTATAAA 
               
               
                   
                   
                 GGATAAATGGAGCGAAGAAACCCATCTGAGCGGGGGGTACCTGCTGGATTTTCTGG 
               
               
                   
                   
                 CCATGCATCTGTGGAGAGCGGTTGTGAGACACAAGAATCGCCTGCTACTGTTGTCTT 
               
               
                   
                   
                 CCGTCCGCCCGGCGATAATACCGACGGAGGAGCAGCAGCAGCAGCAGGAGGAAGC 
               
               
                   
                   
                 CAGGCGGCGGCGGCAGGAGCAGAGCCCATGGAACCCGAGAGCCGGCCTGGACCC 
               
               
                   
                   
                 TCGGGAATGAATGTTGTACAGGTGGCTGAACTGTATCCAGAACTGAGACGCATTTTG 
               
               
                   
                   
                 ACAATTACAGAGGATGGGCAGGGGCTAAAGGGGGTAAAGAGGGAGCGGGGGGCTT 
               
               
                   
                   
                 GTGAGGCTACAGAGGAGGCTAGGAATCTAGCTTTTAGCTTAATGACCAGACACCGTC 
               
               
                   
                   
                 CTGAGTGTATTACTTTTCAACAGATCAAGGATAATTGCGCTAATGAGCTTGATCTGCT 
               
               
                   
                   
                 GGCGCAGAAGTATTCCATAGAGCAGCTGACCACTTACTGGCTGCAGCCAGGGGATG 
               
               
                   
                   
                 ATTTTGAGGAGGCTATTAGGGTATATGCAAAGGTGGCACTTAGGCCAGATTGCAAGT 
               
               
                   
                   
                 ACAAGATCAGCAAACTTGTAAATATCAGGAATTGTTGCTACATTTCTGGGAACGGGG 
               
               
                   
                   
                 CCGAGGTGGAGATAGATACGGAGGATAGGGTGGCCTTTAGATGTAGCATGATAAAT 
               
               
                   
                   
                 ATGTGGCCGGGGGTGCTTGGCATGGACGGGGTGGTTATTATGAATGTAAGGTTTAC 
               
               
                   
                   
                 TGGCCCCAATTTTAGCGGTACGGTTTTCCTGGCCAATACCAACCTTATCCTACACGG 
               
               
                   
                   
                 TGTAAGCTTCTATGGGTTTAACAATACCTGTGTGGAAGCCTGGACCGATGTAAGGGT 
               
               
                   
                   
                 TCGGGGCTGTGCCTTTTACTGCTGCTGGAAGGGGGTGGTGTGTCGCCCCAAAAGCA 
               
               
                   
                   
                 GGGCTTCAATTAAGAAATGCCTCTTTGAAAGGTGTACCTTGGGTATCCTGTCTGAGG 
               
               
                   
                   
                 GTAACTCCAGGGTGCGCCACAATGTGGCCTCCGACTGTGGTTGCTTCATGCTAGTG 
               
               
                   
                   
                 AAAAGCGTGGCTGTGATTAAGCATAACATGGTATGTGGCAACTGCGAGGACAGGGC 
               
               
                   
                   
                 CTCTCAGATGCTGACCTGCTCGGACGGCAACTGTCACCTGCTGAAGACCATTCACG 
               
               
                   
                   
                 TAGCCAGCCACTCTCGCAAGGCCTGGCCAGTGTTTGAGCATAACATACTGACCCGC 
               
               
                   
                   
                 TGTTCCTTGCATTTGGGTAACAGGAGGGGGGTGTTCCTACCTTACCAATGCAATTTG 
               
               
                   
                   
                 AGTCACACTAAGATATTGCTTGAGCCCGAGAGCATGTCCAAGGTGAACCTGAACGG 
               
               
                   
                   
                 GGTGTTTGACATGACCATGAAGATCTGGAAGGTGCTGAGGTACGATGAGACCCGCA 
               
               
                   
                   
                 CCAGGTGCAGACCCTGCGAGTGTGGCGGTAAACATATTAGGAACCAGCCTGTGATG 
               
               
                   
                   
                 CTGGATGTGACCGAGGAGCTGAGGCCCGATCACTTGGTGCTGGCCTGCACCCGCG 
               
               
                   
                   
                 CTGAGTTTGGCTCTAGCGATGAAGATACAGATTGAGGTACTGAAATGTGTGGGCGTG 
               
               
                   
                   
                 GCTTAAGGGTGGGAAAGAATATATAAGGTGGGGGTCTTATGTAGTTTTGTATCTGTTT 
               
               
                   
                   
                 TGCAGCAGCCGCCGCCGCCATGAGCACCAACTCGTTTGATGGAAGCATTGTGAGCT 
               
               
                   
                   
                 CATATTTGACAACGCGCATGCCCCCATGGGCCGGGGTGCGTCAGAATGTGATGGGC 
               
               
                   
                   
                 TCCAGCATTGATGGTCGCCCCGTCCTGCCCGCAAACTCTACTACCTTGACCTACGAG 
               
               
                   
                   
                 ACCGTGTCTGGAACGCCGTTGGAGACTGCAGCCTCCGCCGCCGCTTCAGCCGCTG 
               
               
                   
                   
                 CAGCCACCGCCCGCGGGATTGTGACTGACTTTGCTTTCCTGAGCCCGCTTGCAAGC 
               
               
                   
                   
                 AGTGCAGCTTCCCGTTCATCCGCCCGCGATGACAAGTTGACGGCTCTTTTGGCACA 
               
               
                   
                   
                 ATTGGATTCTTTGACCCGGGAACTTAATGTCGTTTCTCAGCAGCTGTTGGATCTGCG 
               
               
                   
                   
                 CCAGCAGGTTTCTGCCCTGAAGGCTTCCTCCCCTCCCAATGCGGTTTAAAACATAAA 
               
               
                   
                   
                 TAAAAAACCAGACTCTGTTTGGATTTGGATCAAGCAAGTGTCTTGCTGTCTTTATTTA 
               
               
                   
                   
                 GGGGTTTTGCGCGCGCGGTAGGCCCGGGACCAGCGGTCTCGGTCGTTGAGGGTCC 
               
               
                   
                   
                 TGTGTATTTTTTCCAGGACGTGGTAAAGGTGACTCTGGATGTTCAGATACATGGGCA 
               
               
                   
                   
                 TAAGCCCGTCTCTGGGGTGGAGGTAGCACCACTGCAGAGCTTCATGCTGCGGGGT 
               
               
                   
                   
                 GGTGTTGTAGATGATCCAGTCGTAGCAGGAGCGCTGGGCGTGGTGCCTAAAAATGT 
               
               
                   
                   
                 CTTTCAGTAGCAAGCTGATTGCCAGGGGCAGGCCCTTGGTGTAAGTGTTTACAAAGC 
               
               
                   
                   
                 GGTTAAGCTGGGATGGGTGCATACGTGGGGATATGAGATGCATCTTGGACTGTATTT 
               
               
                   
                   
                 TTAGGTTGGCTATGTTCCCAGCCATATCCCTCCGGGGATTCATGTTGTGCAGAACCA 
               
               
                   
                   
                 CCAGCACAGTGTATCCGGTGCACTTGGGAAATTTGTCATGTAGCTTAGAAGGAAATG 
               
               
                   
                   
                 CGTGGAAGAACTTGGAGACGCCCTTGTGACCTCCAAGATTTTCCATGCATTCGTCCA 
               
               
                   
                   
                 TAATGATGGCAATGGGCCCACGGGCGGCGGCCTGGGCGAAGATATTTCTGGGATCA 
               
               
                   
                   
                 CTAACGTCATAGTTGTGTTCCAGGATGAGATCGTCATAGGCCATTTTTACAAAGCGC 
               
               
                   
                   
                 GGGCGGAGGGTGCCAGACTGCGGTATAATGGTTCCATCCGGCCCAGGGGCGTAGT 
               
               
                   
                   
                 TACCCTCACAGATTTGCATTTCCCACGCTTTGAGTTCAGATGGGGGGATCATGTCTA 
               
               
                   
                   
                 CCTGCGGGGCGATGAAGAAAACGGTTTCCGGGGTAGGGGAGATCAGCTGGGAAGA 
               
               
                   
                   
                 AAGCAGGTTCCTGAGCAGCTGCGACTTACCGCAGCCGGTGGGCCCGTAAATCACAC 
               
               
                   
                   
                 CTATTACCGGGTGCAACTGGTAGTTAAGAGAGCTGCAGCTGCCGTCATCCCTGAGC 
               
               
                   
                   
                 AGGGGGGCCACTTCGTTAAGCATGTCCCTGACTCGCATGTTTTCCCTGACCAAATCC 
               
               
                   
                   
                 GCCAGAAGGCGCTCGCCGCCCAGCGATAGCAGTTCTTGCAAGGAAGCAAAGTTTTT 
               
               
                   
                   
                 CAACGGTTTGAGACCGTCCGCCGTAGGCATGCTTTTGAGCGTTTGACCAAGCAGTT 
               
               
                   
                   
                 CCAGGCGGTCCCACAGCTCGGTCACCTGCTCTACGGCATCTCGATCCAGCATATCT 
               
               
                   
                   
                 CCTCGTTTCGCGGGTTGGGGCGGCTTTCGCTGTACGGCAGTAGTCGGTGCTCGTCC 
               
               
                   
                   
                 AGACGGGCCAGGGTCATGTCTTTCCACGGGCGCAGGGTCCTCGTCAGCGTAGTCT 
               
               
                   
                   
                 GGGTCACGGTGAAGGGGTGCGCTCCGGGCTGCGCGCTGGCCAGGGTGCGCTTGA 
               
               
                   
                   
                 GGCTGGTCCTGCTGGTGCTGAAGCGCTGCCGGTCTTCGCCCTGCGCGTCGGCCAG 
               
               
                   
                   
                 GTAGCATTTGACCATGGTGTCATAGTCCAGCCCCTCCGCGGCGTGGCCCTTGGCGC 
               
               
                   
                   
                 GCAGCTTGCCCTTGGAGGAGGCGCCGCACGAGGGGCAGTGCAGACTTTTGAGGGC 
               
               
                   
                   
                 GTAGAGCTTGGGCGCGAGAAATACCGATTCCGGGGAGTAGGCATCCGCGCCGCAG 
               
               
                   
                   
                 GCCCCGCAGACGGTCTCGCATTCCACGAGCCAGGTGAGCTCTGGCCGTTCGGGGT 
               
               
                   
                   
                 CAAAAACCAGGTTTCCCCCATGCTTTTTGATGCGTTTCTTACCTCTGGTTTCCATGAG 
               
               
                   
                   
                 CCGGTGTCCACGCTCGGTGACGAAAAGGCTGTCCGTGTCCCCGTATACAGACTNNN 
               
               
                   
                   
                 GTTTTGAGAGGCCTGTCCTCGAGCGGTGTTCCGCGGTCCTCCTCGTATAGAAACTC 
               
               
                   
                   
                 GGACCACTCTGAGACAAAGGCTCGCGTCCAGGCCAGCACGAAGGAGGCTAAGTGG 
               
               
                   
                   
                 GAGGGGTAGCGGTCGTTGTCCACTAGGGGGTCCACTCGCTCCAGGGTGTGAAGAC 
               
               
                   
                   
                 ACATGTCGCCCTCTTCGGCATCAAGGAAGGTGATTGGTTTGTAGGTGTAGGCCACG 
               
               
                   
                   
                 TGACCGGGTGTTCCTGAAGGGGGGCTATAAAAGGGGGTGGGGGCGCGTTCGTCCT 
               
               
                   
                   
                 CACTCTCTTCCGCATCGCTGTCTGCGAGGGCCAGCTGTTGGGGTGAGTACTCCCTC 
               
               
                   
                   
                 TGAAAAGCGGGCATGACTTCTGCGCTAAGATTGTCAGTTTCCAAAAACGAGGAGGAT 
               
               
                   
                   
                 TTGATATTCACCTGGCCCGCGGTGATGCCTTTGAGGGTGGCCGCATCCATCTGGTC 
               
               
                   
                   
                 AGAAAAGACAATCTTTTTGTTGTCAAGCTTGGTGGCAAACGACCCGTAGAGGGCGTT 
               
               
                   
                   
                 GGACAGCAACTTGGCGATGGAGCGCAGGGTTTGGTTTTTGTCGCGATCGGCGCGCT 
               
               
                   
                   
                 CCTTGGCCGCGATGTTTAGCTGCACGTATTCGCGCGCAACGCACCGCCATTCGGGA 
               
               
                   
                   
                 AAGACGGTGGTGCGCTCGTCGGGCACCAGGTGCACGCGCCAACCGCGGTTGTGCA 
               
               
                   
                   
                 GGGTGACAAGGTCAACGCTGGTGGCTACCTCTCCGCGTAGGCGCTCGTTGGTCCA 
               
               
                   
                   
                 GCAGAGGCGGCCGCCCTTGCGCGAGCAGAATGGCGGTAGGGGGTCTAGCTGCGTC 
               
               
                   
                   
                 TCGTCCGGGGGGTCTGCGTCCACGGTAAAGACCCCGGGCAGCAGGCGCGCGTCGA 
               
               
                   
                   
                 AGTAGTCTATCTTGCATCCTTGCAAGTCTAGCGCCTGCTGCCATGCGCGGGCGGCA 
               
               
                   
                   
                 AGCGCGCGCTCGTATGGGTTGAGTGGGGGACCCCATGGCATGGGGTGGGTGAGCG 
               
               
                   
                   
                 CGGAGGCGTACATGCCGCAAATGTCGTAAACGTAGAGGGGCTCTCTGAGTATTCCA 
               
               
                   
                   
                 AGATATGTAGGGTAGCATCTTCCACCGCGGATGCTGGCGCGCACGTAATCGTATAG 
               
               
                   
                   
                 TTCGTGCGAGGGAGCGAGGAGGTCGGGACCGAGGTTGCTACGGGCGGGCTGCTCT 
               
               
                   
                   
                 GCTCGGAAGACTATCTGCCTGAAGATGGCATGTGAGTTGGATGATATGGTTGGACG 
               
               
                   
                   
                 CTGGAAGACGTTGAAGCTGGCGTCTGTGAGACCTACCGCGTCACGCACGAAGGAG 
               
               
                   
                   
                 GCGTAGGAGTCGCGCAGCTTGTTGACCAGCTCGGCGGTGACCTGCACGTCTAGGG 
               
               
                   
                   
                 CGCAGTAGTCCAGGGTTTCCTTGATGATGTCATACTTATCCTGTCCCTTTTTTTTCCA 
               
               
                   
                   
                 CAGCTCGCGGTTGAGGACAAACTCTTCGCGGTCTTTCCAGTACTCTTGGATCGGAAA 
               
               
                   
                   
                 CCCGTCGGCCTCCGAACGGTAAGAGCCTAGCATGTAGAACTGGTTGACGGCCTGGT 
               
               
                   
                   
                 AGGCGCAGCATCCCTTTTCTACGGGTAGCGCGTATGCCTGCGCGGCCTTCCGGAGC 
               
               
                   
                   
                 GAGGTGTGGGTGAGCGCAAAGGTGTCCCTGACCATGACTTTGAGGTACTGGTATTT 
               
               
                   
                   
                 GAAGTCAGTGTCGTCGCATCCGCCCTGCTCCCAGAGCAAAAAGTCCGTGCGCTTTT 
               
               
                   
                   
                 TGGAACGCGGATTTGGCAGGGCGAAGGTGACATCGTTGAAGAGTATCTTTCCCGCG 
               
               
                   
                   
                 CGAGGCATAAAGTTGCGTGTGATGCGGAAGGGTCCCGGCACCTCGGAACGGTTGTT 
               
               
                   
                   
                 AATTACCTGGGCGGCGAGCACGATCTCGTCAAAGCCGTTGATGTTGTGGCCCACAA 
               
               
                   
                   
                 TGTAAAGTTCCAAGAAGCGCGGGATGCCCTTGATGGAAGGCAATTTTTTAAGTTCCT 
               
               
                   
                   
                 CGTAGGTGAGCTCTTCAGGGGAGCTGAGCCCGTGCTCTGAAAGGGCCCAGTCTGC 
               
               
                   
                   
                 AAGATGAGGGTTGGAAGCGACGAATGAGCTCCACAGGTCACGGGCCATTAGCATTT 
               
               
                   
                   
                 GCAGGTGGTCGCGAAAGGTCCTAAACTGGCGACCTATGGCCATTTTTTCTGGGGTG 
               
               
                   
                   
                 ATGCAGTAGAAGGTAAGCGGGTCTTGTTCCCAGCGGTCCCATCCAAGGTTCGCGGC 
               
               
                   
                   
                 TAGGTCTCGCGCGGCAGTCACTAGAGGCTCATCTCCGCCGAACTTCATGACCAGCA 
               
               
                   
                   
                 TGAAGGGCACGAGCTGCTTCCCAAAGGCCCCCATCCAAGTATAGGTCTCTACATCG 
               
               
                   
                   
                 TAGGTGACAAAGAGACGCTCGGTGCGAGGATGCGAGCCGATCGGGAAGAACTGGA 
               
               
                   
                   
                 TCTCCCGCCACCAATTGGAGGAGTGGCTATTGATGTGGTGAAAGTAGAAGTCCCTG 
               
               
                   
                   
                 CGACGGGCCGAACACTCGTGCTGGCTTTTGTAAAAACGTGCGCAGTACTGGCAGCG 
               
               
                   
                   
                 GTGCACGGGCTGTACATCCTGCACGAGGTTGACCTGACGACCGCGCACAAGGAAG 
               
               
                   
                   
                 CAGAGTGGGAATTTGAGCCCCTCGCCTGGCGGGTTTGGCTGGTGGTCTTCTACTTC 
               
               
                   
                   
                 GGCTGCTTGTCCTTGACCGTCTGGCTGCTCGAGGGGAGTTACGGTGGATCGGACCA 
               
               
                   
                   
                 CCACGCCGCGCGAGCCCAAAGTCCAGATGTCCGCGCGCGGCGGTCGGAGCTTGAT 
               
               
                   
                   
                 GACAACATCGCGCAGATGGGAGCTGTCCATGGTCTGGAGCTCCCGCGGCGTCAGG 
               
               
                   
                   
                 TCAGGCGGGAGCTCCTGCAGGTTTACCTCGCATAGACGGGTCAGGGCGCGGGCTA 
               
               
                   
                   
                 GATCCAGGTGATACCTAATTTCCAGGGGCTGGTTGGTGGCGGCGTCGATGGCTTGC 
               
               
                   
                   
                 AAGAGGCCGCATCCCCGCGGCGCGACTACGGTACCGCGCGGCGGGCGGTGGGCC 
               
               
                   
                   
                 GCGGGGGTGTCCTTGGATGATGCATCTAAAAGCGGTGACGCGGGCGAGCCCCCGG 
               
               
                   
                   
                 AGGTAGGGGGGGCTCCGGACCCGCCGGGAGAGGGGGCAGGGGCACGTCGGCGC 
               
               
                   
                   
                 CGCGCGCGGGCAGGAGCTGGTGCTGCGCGCGTAGGTTGCTGGCGAACGCGACGA 
               
               
                   
                   
                 CGCGGCGGTTGATCTCCTGAATCTGGCGCCTCTGCGTGAAGACGACGGGCCCGGT 
               
               
                   
                   
                 GAGCTTGAGCCTGAAAGAGAGTTCGACAGAATCAATTTCGGTGTCGTTGACGGCGG 
               
               
                   
                   
                 CCTGGCGCAAAATCTCCTGCACGTCTCCTGAGTTGTCTTGATAGGCGATCTCGGCCA 
               
               
                   
                   
                 TGAACTGCTCGATCTCTTCCTCCTGGAGATCTCCGCGTCCGGCTCGCTCCACGGTG 
               
               
                   
                   
                 GCGGCGAGGTCGTTGGAAATGCGGGCCATGAGCTGCGAGAAGGCGTTGAGGCCTC 
               
               
                   
                   
                 CCTCGTTCCAGACGCGGCTGTAGACCACGCCCCCTTCGGCATCGCGGGCGCGCAT 
               
               
                   
                   
                 GACCACCTGCGCGAGATTGAGCTCCACGTGCCGGGCGAAGACGGCGTAGTTTCGC 
               
               
                   
                   
                 AGGCGCTGAAAGAGGTAGTTGAGGGTGGTGGCGGTGTGTTCTGCCACGAAGAAGTA 
               
               
                   
                   
                 CATAACCCAGCGTCGCAACGTGGATTCGTTGATATCCCCCAAGGCCTCAAGGCGCT 
               
               
                   
                   
                 CCATGGCCTCGTAGAAGTCCACGGCGAAGTTGAAAAACTGGGAGTTGCGCGCCGAC 
               
               
                   
                   
                 ACGGTTAACTCCTCCTCCAGAAGACGGATGAGCTCGGCGACAGTGTCGCGCACCTC 
               
               
                   
                   
                 GCGCTCAAAGGCTACAGGGGCCTCTTCTTCTTCTTCAATCTCCTCTTCCATAAGGGC 
               
               
                   
                   
                 CTCCCCTTCTTCTTCTTCTGGCGGCGGTGGGGGAGGGGGGACACGGCGGCGACGA 
               
               
                   
                   
                 CGGCGCACCGGGAGGCGGTCGACAAAGCGCTCGATCATCTCCCCGCGGCGACGG 
               
               
                   
                   
                 CGCATGGTCTCGGTGACGGCGCGGCCGTTCTCGCGGGGGCGCAGTTGGAAGACGC 
               
               
                   
                   
                 CGCCCGTCATGTCCCGGTTATGGGTTGGCGGGGGGCTGCCATGCGGCAGGGATAC 
               
               
                   
                   
                 GGCGCTAACGATGCATCTCAACAATTGTTGTGTAGGTACTCCGCCGCCGAGGGACC 
               
               
                   
                   
                 TGAGCGAGTCCGCATCGACCGGATCGGAAAACCTCTCGAGAAAGGCGTCTAACCAG 
               
               
                   
                   
                 TCACAGTCGCAAGGTAGGCTGAGCACCGTGGCGGGCGGCAGCGGGCGGCGGTCG 
               
               
                   
                   
                 GGGTTGTTTCTGGCGGAGGTGCTGCTGATGATGTAATTAAAGTAGGCGGTCTTGAG 
               
               
                   
                   
                 ACGGCGGATGGTCGACAGAAGCACCATGTCCTTGGGTCCGGCCTGCTGAATGCGC 
               
               
                   
                   
                 AGGCGGTCGGCCATGCCCCAGGCTTCGTTTTGACATCGGCGCAGGTCTTTGTAGTA 
               
               
                   
                   
                 GTCTTGCATGAGCCTTTCTACCGGCACTTCTTCTTCTCCTTCCTCTTGTCCTGCATCT 
               
               
                   
                   
                 CTTGCATCTATCGCTGCGGCGGCGGCGGAGTTTGGCCGTAGGTGGCGCCCTCTTC 
               
               
                   
                   
                 CTCCCATGCGTGTGACCCCGAAGCCCCTCATCGGCTGAAGCAGGGCTAGGTCGGC 
               
               
                   
                   
                 GACAACGCGCTCGGCTAATATGGCCTGCTGCACCTGCGTGAGGGTAGACTGGAAGT 
               
               
                   
                   
                 CATCCATGTCCACAAAGCGGTGGTATGCGCCCGTGTTGATGGTGTAAGTGCAGTTG 
               
               
                   
                   
                 GCCATAACGGACCAGTTAACGGTCTGGTGACCCGGCTGCGAGAGCTCGGTGTACCT 
               
               
                   
                   
                 GAGACGCGAGTAAGCCCTCGAGTCAAATACGTAGTCGTTGCAAGTCCGCACCAGGT 
               
               
                   
                   
                 ACTGGTATCCCACCAAAAAGTGCGGCGGCGGCTGGCGGTAGAGGGGCCAGCGTAG 
               
               
                   
                   
                 GGTGGCCGGGGCTCCGGGGGCGAGATCTTCCAACATAAGGCGATGATATCCGTAG 
               
               
                   
                   
                 ATGTACCTGGACATCCAGGTGATGCCGGCGGCGGTGGTGGAGGCGCGCGGAAAGT 
               
               
                   
                   
                 CGCGGACGCGGTTCCAGATGTTGCGCAGCGGCAAAAAGTGCTCCATGGTCGGGAC 
               
               
                   
                   
                 GCTCTGGCCGGTCAGGCGCGCGCAATCGTTGACGCTCTACCGTGCAAAAGGAGAG 
               
               
                   
                   
                 CCTGTAAGCGGGCACTCTTCCGTGGTCTGGTGGATAAATTCGCAAGGGTATCATGG 
               
               
                   
                   
                 CGGACGACCGGGGTTCGAGCCCCGTATCCGGCCGTCCGCCGTGATCCATGCGGTT 
               
               
                   
                   
                 ACCGCCCGCGTGTCGAACCCAGGTGTGCGACGTCAGACAACGGGGGAGTGCTCCT 
               
               
                   
                   
                 TTTGGCTTCCTTCCAGGCGCGGCGGCTGCTGCGCTAGCTTTTTTGGCCACTGGCCG 
               
               
                   
                   
                 CGCGCAGCGTAAGCGGTTAGGCTGGAAAGCGAAAGCATTAAGTGGCTCGCTCCCTG 
               
               
                   
                   
                 TAGCCGGAGGGTTATTTTCCAAGGGTTGAGTCGCGGGACCCCCGGTTCGAGTCTCG 
               
               
                   
                   
                 GACCGGCCGGACTGCGGCGAACGGGGGTTTGCCTCCCCGTCATGCAAGACCCCGC 
               
               
                   
                   
                 TTGCAAATTCCTCCGGAAACAGGGACGAGCCCCTTTTTTGCTTTTCCCAGATGCATC 
               
               
                   
                   
                 CGGTGCTGCGGCAGATGCGCCCCCCTCCTCAGCAGCGGCAAGAGCAAGAGCAGCG 
               
               
                   
                   
                 GCAGACATGCAGGGCACCCTCCCCTCCTCCTACCGCGTCAGGAGGGGCGACATCC 
               
               
                   
                   
                 GCGGTTGACGCGGCAGCAGATGGTGATTACGAACCCCCGCGGCGCCGGGCCCGG 
               
               
                   
                   
                 CACTACCTGGACTTGGAGGAGGGCGAGGGCCTGGCGCGGCTAGGAGCGCCCTCTC 
               
               
                   
                   
                 CTGAGCGGTACCCAAGGGTGCAGCTGAAGCGTGATACGCGTGAGGCGTACGTGCC 
               
               
                   
                   
                 GCGGCAGAACCTGTTTCGCGACCGCGAGGGAGAGGAGCCCGAGGAGATGCGGGAT 
               
               
                   
                   
                 CGAAAGTTCCACGCAGGGCGCGAGCTGCGGCATGGCCTGAATCGCGAGCGGTTGC 
               
               
                   
                   
                 TGCGCGAGGAGGACTTTGAGCCCGACGCGCGAACCGGGATTAGTCCCGCGCGCGC 
               
               
                   
                   
                 ACACGTGGCGGCCGCCGACCTGGTAACCGCATACGAGCAGACGGTGAACCAGGAG 
               
               
                   
                   
                 ATTAACTTTCAAAAAAGCTTTAACAACCACGTGCGTACGCTTGTGGCGCGCGAGGAG 
               
               
                   
                   
                 GTGGCTATAGGACTGATGCATCTGTGGGACTTTGTAAGCGCGCTGGAGCAAAACCC 
               
               
                   
                   
                 AAATAGCAAGCCGCTCATGGCGCAGCTGTTCCTTATAGTGCAGCACAGCAGGGACA 
               
               
                   
                   
                 ACGAGGCATTCAGGGATGCGCTGCTAAACATAGTAGAGCCCGAGGGCCGCTGGCT 
               
               
                   
                   
                 GCTCGATTTGATAAACATCCTGCAGAGCATAGTGGTGCAGGAGCGCAGCTTGAGCC 
               
               
                   
                   
                 TGGCTGACAAGGTGGCCGCCATCAACTATTCCATGCTTAGCCTGGGCAAGTTTTACG 
               
               
                   
                   
                 CCCGCAAGATATACCATACCCCTTACGTTCCCATAGACAAGGAGGTAAAGATCGAGG 
               
               
                   
                   
                 GGTTCTACATGCGCATGGCGCTGAAGGTGCTTACCTTGAGCGACGACCTGGGCGTT 
               
               
                   
                   
                 TATCGCAACGAGCGCATCCACAAGGCCGTGAGCGTGAGCCGGCGGCGCGAGCTCA 
               
               
                   
                   
                 GCGACCGCGAGCTGATGCACAGCCTGCAAAGGGCCCTGGCTGGCACGGGCAGCG 
               
               
                   
                   
                 GCGATAGAGAGGCCGAGTCCTACTTTGACGCGGGCGCTGACCTGCGCTGGGCCCC 
               
               
                   
                   
                 AAGCCGACGCGCCCTGGAGGCAGCTGGGGCCGGACCTGGGCTGGCGGTGGCACC 
               
               
                   
                   
                 CGCGCGCGCTGGCAACGTCGGCGGCGTGGAGGAATATGACGAGGACGATGAGTAC 
               
               
                   
                   
                 GAGCCAGAGGACGGCGAGTACTAAGCGGTGATGTTTCTGATCAGATGATGCAAGAC 
               
               
                   
                   
                 GCAACGGACCCGGCGGTGCGGGCGGCGCTGCAGAGCCAGCCGTCCGGCCTTAAC 
               
               
                   
                   
                 TCCACGGACGACTGGCGCCAGGTCATGGACCGCATCATGTCGCTGACTGCGCGCA 
               
               
                   
                   
                 ATCCTGACGCGTTCCGGCAGCAGCCGCAGGCCAACCGGCTCTCCGCAATTCTGGAA 
               
               
                   
                   
                 GCGGTGGTCCCGGCGCGCGCAAACCCCACGCACGAGAAGGTGCTGGCGATCGTAA 
               
               
                   
                   
                 ACGCGCTGGCCGAAAACAGGGCCATCCGGCCCGACGAGGCCGGCCTGGTCTACGA 
               
               
                   
                   
                 CGCGCTGCTTCAGCGCGTGGCTCGTTACAACAGCGGCAACGTGCAGACCAACCTG 
               
               
                   
                   
                 GACCGGCTGGTGGGGGATGTGCGCGAGGCCGTGGCGCAGCGTGAGCGCGCGCAG 
               
               
                   
                   
                 CAGCAGGGCAACCTGGGCTCCATGGTTGCACTAAACGCCTTCCTGAGTACACAGCC 
               
               
                   
                   
                 CGCCAACGTGCCGCGGGGACAGGAGGACTACACCAACTTTGTGAGCGCACTGCGG 
               
               
                   
                   
                 CTAATGGTGACTGAGACACCGCAAAGTGAGGTGTACCAGTCTGGGCCAGACTATTTT 
               
               
                   
                   
                 TTCCAGACCAGTAGACAAGGCCTGCAGACCGTAAACCTGAGCCAGGCTTTCAAAAA 
               
               
                   
                   
                 CTTGCAGGGGCTGTGGGGGGTGCGGGCTCCCACAGGCGACCGCGCGACCGTGTC 
               
               
                   
                   
                 TAGCTTGCTGACGCCCAACTCGCGCCTGTTGCTGCTGCTAATAGCGCCCTTCACGG 
               
               
                   
                   
                 ACAGTGGCAGCGTGTCCCGGGACACATACCTAGGTCACTTGCTGACACTGTACCGC 
               
               
                   
                   
                 GAGGCCATAGGTCAGGCGCATGTGGACGAGCATACTTTCCAGGAGATTACAAGTGT 
               
               
                   
                   
                 CAGCCGCGCGCTGGGGCAGGAGGACACGGGCAGCCTGGAGGCAACCCTAAACTAC 
               
               
                   
                   
                 CTGCTGACCAACCGGCGGCAGAAGATCCCCTCGTTGCACAGTTTAAACAGCGAGGA 
               
               
                   
                   
                 GGAGCGCATTTTGCGCTACGTGCAGCAGAGCGTGAGCCTTAACCTGATGCGCGACG 
               
               
                   
                   
                 GGGTAACGCCCAGCGTGGCGCTGGACATGACCGCGCGCAACATGGAACCGGGCAT 
               
               
                   
                   
                 GTATGCCTCAAACCGGCCGTTTATCAACCGCCTAATGGACTACTTGCATCGCGCGG 
               
               
                   
                   
                 CCGCCGTGAACCCCGAGTATTTCACCAATGCCATCTTGAACCCGCACTGGCTACCG 
               
               
                   
                   
                 CCCCCTGGTTTCTACACCGGGGGATTCGAGGTGCCCGAGGGTAACGATGGATTCCT 
               
               
                   
                   
                 CTGGGACGACATAGACGACAGCGTGTTTTCCCCGCAACCGCAGACCCTGCTAGAGT 
               
               
                   
                   
                 TGCAACAGCGCGAGCAGGCAGAGGCGGCGCTGCGAAAGGAAAGCTTCCGCAGGCC 
               
               
                   
                   
                 AAGCAGCTTGTCCGATCTAGGCGCTGCGGCCCCGCGGTCAGATGCTAGTAGCCCAT 
               
               
                   
                   
                 TTCCAAGCTTGATAGGGTCTCTTACCAGCACTCGCACCACCCGCCCGCGCCTGCTG 
               
               
                   
                   
                 GGCGAGGAGGAGTACCTAAACAACTCGCTGCTGCAGCCGCAGCGCGAAAAAAACCT 
               
               
                   
                   
                 GCCTCCGGCATTTCCCAACAACGGGATAGAGAGCCTAGTGGACAAGATGAGTAGAT 
               
               
                   
                   
                 GGAAGACGTACGCGCAGGAGCACAGGGACGTGCCAGGCCCGCGCCCGCCCACCC 
               
               
                   
                   
                 GTCGTCAAAGGCACGACCGTCAGCGGGGTCTGGTGTGGGAGGACGATGACTCGGC 
               
               
                   
                   
                 AGACGACAGCAGCGTCCTGGATTTGGGAGGGAGTGGCAACCCGTTTGCGCACCTTC 
               
               
                   
                   
                 GCCCCAGGCTGGGGAGAATGTTTTAAAAAAAAAAAAGCATGATGCAAAATAAAAAAC 
               
               
                   
                   
                 TCACCAAGGCCATGGCACCGAGCGTTGGTTTTCTTGTATTCCCCTTAGTATGCGGCG 
               
               
                   
                   
                 CGCGGCGATGTATGAGGAAGGTCCTCCTCCCTCCTACGAGAGTGTGGTGAGCGCG 
               
               
                   
                   
                 GCGCCAGTGGCGGCGGCGCTGGGTTCTCCCTTCGATGCTCCCCTGGACCCGCCGT 
               
               
                   
                   
                 TTGTGCCTCCGCGGTACCTGCGGCCTACCGGGGGGAGAAACAGCATCCGTTACTCT 
               
               
                   
                   
                 GAGTTGGCACCCCTATTCGACACCACCCGTGTGTACCTGGTGGACAACAAGTCAAC 
               
               
                   
                   
                 GGATGTGGCATCCCTGAACTACCAGAACGACCACAGCAACTTTCTGACCACGGTCAT 
               
               
                   
                   
                 TCAAAACAATGACTACAGCCCGGGGGAGGCAAGCACACAGACCATCAATCTTGACG 
               
               
                   
                   
                 ACCGGTCGCACTGGGGCGGCGACCTGAAAACCATCCTGCATACCAACATGCCAAAT 
               
               
                   
                   
                 GTGAACGAGTTCATGTTTACCAATAAGTTTAAGGCGCGGGTGATGGTGTCGCGCTTG 
               
               
                   
                   
                 CCTACTAAGGACAATCAGGTGGAGCTGAAATACGAGTGGGTGGAGTTCACGCTGCC 
               
               
                   
                   
                 CGAGGGCAACTACTCCGAGACCATGACCATAGACCTTATGAACAACGCGATCGTGG 
               
               
                   
                   
                 AGCACTACTTGAAAGTGGGCAGACAGAACGGGGTTCTGGAAAGCGACATCGGGGTA 
               
               
                   
                   
                 AAGTTTGACACCCGCAACTTCAGACTGGGGTTTGACCCCGTCACTGGTCTTGTCATG 
               
               
                   
                   
                 CCTGGGGTATATACAAACGAAGCCTTCCATCCAGACATCATTTTGCTGCCAGGATGC 
               
               
                   
                   
                 GGGGTGGACTTCACCCACAGCCGCCTGAGCAACTTGTTGGGCATCCGCAAGCGGC 
               
               
                   
                   
                 AACCCTTCCAGGAGGGCTTTAGGATCACCTACGATGATCTGGAGGGTGGTAACATTC 
               
               
                   
                   
                 CCGCACTGTTGGATGTGGACGCCTACCAGGCGAGCTTGAAAGATGACACCGAACAG 
               
               
                   
                   
                 GGCGGGGGTGGCGCAGGCGGCAGCAACAGCAGTGGCAGCGGCGCGGAAGAGAAC 
               
               
                   
                   
                 TCCAACGCGGCAGCCGCGGCAATGCAGCCGGTGGAGGACATGAACGATCATGCCA 
               
               
                   
                   
                 TTCGCGGCGACACCTTTGCCACACGGGCTGAGGAGAAGCGCGCTGAGGCCGAAGC 
               
               
                   
                   
                 AGCGGCCGAAGCTGCCGCCCCCGCTGCGCAACCCGAGGTCGAGAAGCCTCAGAAG 
               
               
                   
                   
                 AAACCGGTGATCAAACCCCTGACAGAGGACAGCAAGAAACGCAGTTACAACCTAATA 
               
               
                   
                   
                 AGCAATGACAGCACCTTCACCCAGTACCGCAGCTGGTACCTTGCATACAACTACGG 
               
               
                   
                   
                 CGACCCTCAGACCGGAATCCGCTCATGGACCCTGCTTTGCACTCCTGACGTAACCT 
               
               
                   
                   
                 GCGGCTCGGAGCAGGTCTACTGGTCGTTGCCAGACATGATGCAAGACCCCGTGACC 
               
               
                   
                   
                 TTCCGCTCCACGCGCCAGATCAGCAACTTTCCGGTGGTGGGCGCCGAGCTGTTGCC 
               
               
                   
                   
                 CGTGCACTCCAAGAGCTTCTACAACGACCAGGCCGTCTACTCCCAACTCATCCGCC 
               
               
                   
                   
                 AGTTTACCTCTCTGACCCACGTGTTCAATCGCTTTCCCGAGAACCAGATTTTGGCGC 
               
               
                   
                   
                 GCCCGCCAGCCCCCACCATCACCACCGTCAGTGAAAACGTTCCTGCTCTCACAGAT 
               
               
                   
                   
                 CACGGGACGCTACCGCTGCGCAACAGCATCGGAGGAGTCCAGCGAGTGACCATTA 
               
               
                   
                   
                 CTGACGCCAGACGCCGCACCTGCCCCTACGTTTACAAGGCCCTGGGCATAGTCTCG 
               
               
                   
                   
                 CCGCGCGTCCTATCGAGCCGCACTTTTTGAGCAAGCATGTCCATCCTTATATCGCCC 
               
               
                   
                   
                 AGCAATAACACAGGCTGGGGCCTGCGCTTCCCAAGCAAGATGTTTGGCGGGGCCAA 
               
               
                   
                   
                 GAAGCGCTCCGACCAACACCCAGTGCGCGTGCGCGGGCACTACCGCGCGCCCTGG 
               
               
                   
                   
                 GGCGCGCACAAACGCGGCCGCACTGGGCGCACCACCGTCGATGACGCCATCGACG 
               
               
                   
                   
                 CGGTGGTGGAGGAGGCGCGCAACTACACGCCCACGCCGCCACCAGTGTCCACAGT 
               
               
                   
                   
                 GGACGCGGCCATTCAGACCGTGGTGCGCGGAGCCCGGCGCTATGCTAAAATGAAG 
               
               
                   
                   
                 AGACGGCGGAGGCGCGTAGCACGTCGCCACCGCCGCCGACCCGGCACTGCCGCC 
               
               
                   
                   
                 CAACGCGCGGCGGCGGCCCTGCTTAACCGCGCACGTCGCACCGGCCGACGGGCG 
               
               
                   
                   
                 GCCATGCGGGCCGCTCGAAGGCTGGCCGCGGGTATTGTCACTGTGCCCCCCAGGT 
               
               
                   
                   
                 CCAGGCGACGAGCGGCCGCCGCAGCAGCCGCGGCCATTAGTGCTATGACTCAGGG 
               
               
                   
                   
                 TCGCAGGGGCAACGTGTATTGGGTGCGCGACTCGGTTAGCGGCCTGCGCGTGCCC 
               
               
                   
                   
                 GTGCGCACCCGCCCCCCGCGCAACTAGATTGCAAGAAAAAACTACTTAGACTCGTA 
               
               
                   
                   
                 CTGTTGTATGTATCCAGCGGCGGCGGCGCGCAACGAAGCTATGTCCAAGCGCAAAA 
               
               
                   
                   
                 TCAAAGAAGAGATGCTCCAGGTCATCGCGCCGGAGATCTATGGCCCCCCGAAGAAG 
               
               
                   
                   
                 GAAGAGCAGGATTACAAGCCCCGAAAGCTAAAGCGGGTCAAAAAGAAAAAGAAAGA 
               
               
                   
                   
                 TGATGATGATGAACTTGACGACGAGGTGGAACTGCTGCACGCTACCGCGCCCAGGC 
               
               
                   
                   
                 GACGGGTACAGTGGAAAGGTCGACGCGTAAAACGTGTTTTGCGACCCGGCACCACC 
               
               
                   
                   
                 GTAGTCTTTACGCCCGGTGAGCGCTCCACCCGCACCTACAAGCGCGTGTATGATGA 
               
               
                   
                   
                 GGTGTACGGCGACGAGGACCTGCTTGAGCAGGCCAACGAGCGCCTCGGGGAGTTT 
               
               
                   
                   
                 GCCTACGGAAAGCGGCATAAGGACATGCTGGCGTTGCCGCTGGACGAGGGCAACC 
               
               
                   
                   
                 CAACACCTAGCCTAAAGCCCGTAACACTGCAGCAGGTGCTGCCCGCGCTTGCACCG 
               
               
                   
                   
                 TCCGAAGAAAAGCGCGGCCTAAAGCGCGAGTCTGGTGACTTGGCACCCACCGTGCA 
               
               
                   
                   
                 GCTGATGGTACCCAAGCGCCAGCGACTGGAAGATGTCTTGGAAAAAATGACCGTGG 
               
               
                   
                   
                 AACCTGGGCTGGAGCCCGAGGTCCGCGTGCGGCCAATCAAGCAGGTGGCGCCGG 
               
               
                   
                   
                 GACTGGGCGTGCAGACCGTGGACGTTCAGATACCCACTACCAGTAGCACCAGTATT 
               
               
                   
                   
                 GCCACCGCCACAGAGGGCATGGAGACACAAACGTCCCCGGTTGCCTCAGCGGTGG 
               
               
                   
                   
                 CGGATGCCGCGGTGCAGGCGGTCGCTGCGGCCGCGTCCAAGACCTCTACGGAGGT 
               
               
                   
                   
                 GCAAACGGACCCGTGGATGTTTCGCGTTTCAGCCCCCCGGCGCCCGCGCGGTTCG 
               
               
                   
                   
                 AGGAAGTACGGCGCCGCCAGCGCGCTACTGCCCGAATATGCCCTACATCCTTCCAT 
               
               
                   
                   
                 TGCGCCTACCCCCGGCTATCGTGGCTACACCTACCGCCCCAGAAGACGAGCAACTA 
               
               
                   
                   
                 CCCGACGCCGAACCACCACTGGAACCCGCCGCCGCCGTCGCCGTCGCCAGCCCGT 
               
               
                   
                   
                 GCTGGCCCCGATTTCCGTGCGCAGGGTGGCTCGCGAAGGAGGCAGGACCCTGGTG 
               
               
                   
                   
                 CTGCCAACAGCGCGCTACCACCCCAGCATCGTTTAAAAGCCGGTCTTTGTGGTTCTT 
               
               
                   
                   
                 GCAGATATGGCCCTCACCTGCCGCCTCCGTTTCCCGGTGCCGGGATTCCGAGGAAG 
               
               
                   
                   
                 AATGCACCGTAGGAGGGGCATGGCCGGCCACGGCCTGACGGGCGGCATGCGTCGT 
               
               
                   
                   
                 GCGCACCACCGGCGGCGGCGCGCGTCGCACCGTCGCATGCGCGGCGGTATCCTG 
               
               
                   
                   
                 CCCCTCCTTATTCCACTGATCGCCGCGGCGATTGGCGCCGTGCCCGGAATTGCATC 
               
               
                   
                   
                 CGTGGCCTTGCAGGCGCAGAGACACTGATTAAAAACAAGTTGCATGTGGAAAAATCA 
               
               
                   
                   
                 AAATAAAAAGTCTGGACTCTCACGCTCGCTTGGTCCTGTAACTATTTTGTAGAATGGA 
               
               
                   
                   
                 AGACATCAACTTTGCGTCTCTGGCCCCGCGACACGGCTCGCGCCCGTTCATGGGAA 
               
               
                   
                   
                 ACTGGCAAGATATCGGCACCAGCAATATGAGCGGTGGCGCCTTCAGCTGGGGCTCG 
               
               
                   
                   
                 CTGTGGAGCGGCATTAAAAATTTCGGTTCCACCGTTAAGAACTATGGCAGCAAGGCC 
               
               
                   
                   
                 TGGAACAGCAGCACAGGCCAGATGCTGAGGGATAAGTTGAAAGAGCAAAATTTCCA 
               
               
                   
                   
                 ACAAAAGGTGGTAGATGGCCTGGCCTCTGGCATTAGCGGGGTGGTGGACCTGGCC 
               
               
                   
                   
                 AACCAGGCAGTGCAAAATAAGATTAACAGTAAGCTTGATCCCCGCCCTCCCGTAGAG 
               
               
                   
                   
                 GAGCCTCCACCGGCCGTGGAGACAGTGTCTCCAGAGGGGCGTGGCGAAAAGCGTC 
               
               
                   
                   
                 CGCGCCCCGACAGGGAAGAAACTCTGGTGACGCAAATAGACGAGCCTCCCTCGTAC 
               
               
                   
                   
                 GAGGAGGCACTAAAGCAAGGCCTGCCCACCACCCGTCCCATCGCGCCCATGGCTA 
               
               
                   
                   
                 CCGGAGTGCTGGGCCAGCACACACCCGTAACGCTGGACCTGCCTCCCCCCGCCGA 
               
               
                   
                   
                 CACCCAGCAGAAACCTGTGCTGCCAGGCCCGACCGCCGTTGTTGTAACCCGTCCTA 
               
               
                   
                   
                 GCCGCGCGTCCCTGCGCCGCGCCGCCAGCGGTCCGCGATCGTTGCGGCCCGTAG 
               
               
                   
                   
                 CCAGTGGCAACTGGCAAAGCACACTGAACAGCATCGTGGGTCTGGGGGTGCAATCC 
               
               
                   
                   
                 CTGAAGCGCCGACGATGCTTCTGAATAGCTAACGTGTCGTATGTGTGTCATGTATGC 
               
               
                   
                   
                 GTCCATGTCGCCGCCAGAGGAGCTGCTGAGCCGCCGCGCGCCCGCTTTCCAAGAT 
               
               
                   
                   
                 GGCTACCCCTTCGATGATGCCGCAGTGGTCTTACATGCACATCTCGGGCCAGGACG 
               
               
                   
                   
                 CCTCGGAGTACCTGAGCCCCGGGCTGGTGCAGTTTGCCCGCGCCACCGAGACGTA 
               
               
                   
                   
                 CTTCAGCCTGAATAACAAGTTTAGAAACCCCACGGTGGCGCCTACGCACGACGTGA 
               
               
                   
                   
                 CCACAGACCGGTCCCAGCGTTTGACGCTGCGGTTCATCCCTGTGGACCGTGAGGAT 
               
               
                   
                   
                 ACTGCGTACTCGTACAAGGCGCGGTTCACCCTAGCTGTGGGTGATAACCGTGTGCT 
               
               
                   
                   
                 GGACATGGCTTCCACGTACTTTGACATCCGCGGCGTGCTGGACAGGGGCCCTACTT 
               
               
                   
                   
                 TTAAGCCCTACTCTGGCACTGCCTACAACGCCCTGGCTCCCAAGGGTGCCCCAAAT 
               
               
                   
                   
                 CCTTGCGAATGGGATGAAGCTGCTACTGCTCTTGAAATAAACCTAGAAGAAGAGGAC 
               
               
                   
                   
                 GATGACAACGAAGACGAAGTAGACGAGCAAGCTGAGCAGCAAAAAACTCACGTATTT 
               
               
                   
                   
                 GGGCAGGCGCCTTATTCTGGTATAAATATTACAAAGGAGGGTATTCAAATAGGTGTC 
               
               
                   
                   
                 GAAGGTCAAACACCTAAATATGCCGATAAAACATTTCAACCTGAACCTCAAATAGGA 
               
               
                   
                   
                 GAATCTCAGTGGTACGAAACTGAAATTAATCATGCAGCTGGGAGAGTCCTTAAAAAG 
               
               
                   
                   
                 ACTACCCCAATGAAACCATGTTACGGTTCATATGCAAAACCCACAAATGAAAATGGA 
               
               
                   
                   
                 GGGCAAGGCATTCTTGTAAAGCAACAAAATGGAAAGCTAGAAAGTCAAGTGGAAATG 
               
               
                   
                   
                 CAATTTTTCTCAACTACTGAGGCGACCGCAGGCAATGGTGATAACTTGACTCCTAAA 
               
               
                   
                   
                 GTGGTATTGTACAGTGAAGATGTAGATATAGAAACCCCAGACACTCATATTTCTTACA 
               
               
                   
                   
                 TGCCCACTATTAAGGAAGGTAACTCACGAGAACTAATGGGCCAACAATCTATGCCCA 
               
               
                   
                   
                 ACAGGCCTAATTACATTGCTTTTAGGGACAATTTTATTGGTCTAATGTATTACAACAG 
               
               
                   
                   
                 CACGGGTAATATGGGTGTTCTGGCGGGCCAAGCATCGCAGTTGAATGCTGTTGTAG 
               
               
                   
                   
                 ATTTGCAAGACAGAAACACAGAGCTTTCATACCAGCTTTTGCTTGATTCCATTGGTGA 
               
               
                   
                   
                 TAGAACCAGGTACTTTTCTATGTGGAATCAGGCTGTTGACAGCTATGATCCAGATGTT 
               
               
                   
                   
                 AGAATTATTGAAAATCATGGAACTGAAGATGAACTTCCAAATTACTGCTTTCCACTGG 
               
               
                   
                   
                 GAGGTGTGATTAATACAGAGACTCTTACCAAGGTAAAACCTAAAACAGGTCAGGAAA 
               
               
                   
                   
                 ATGGATGGGAAAAAGATGCTACAGAATTTTCAGATAAAAATGAAATAAGAGTTGGAAA 
               
               
                   
                   
                 TAATTTTGCCATGGAAATCAATCTAAATGCCAACCTGTGGAGAAATTTCCTGTACTCC 
               
               
                   
                   
                 AACATAGCGCTGTATTTGCCCGACAAGCTAAAGTACAGTCCTTCCAACGTAAAAATTT 
               
               
                   
                   
                 CTGATAACCCAAACACCTACGACTACATGAACAAGCGAGTGGTGGCTCCCGGGTTA 
               
               
                   
                   
                 GTGGACTGCTACATTAACCTTGGAGCACGCTGGTCCCTTGACTATATGGACAACGTC 
               
               
                   
                   
                 AACCCATTTAACCACCACCGCAATGCTGGCCTGCGCTACCGCTCAATGTTGCTGGG 
               
               
                   
                   
                 CAATGGTCGCTATGTGCCCTTCCACATCCAGGTGCCTCAGAAGTTCTTTGCCATTAA 
               
               
                   
                   
                 AAACCTCCTTCTCCTGCCGGGCTCATACACCTACGAGTGGAACTTCAGGAAGGATGT 
               
               
                   
                   
                 TAACATGGTTCTGCAGAGCTCCCTAGGAAATGACCTAAGGGTTGACGGAGCCAGCA 
               
               
                   
                   
                 TTAAGTTTGATAGCATTTGCCTTTACGCCACCTTCTTCCCCATGGCCCACAACACCG 
               
               
                   
                   
                 CCTCCACGCTTGAGGCCATGCTTAGAAACGACACCAACGACCAGTCCTTTAACGACT 
               
               
                   
                   
                 ATCTCTCCGCCGCCAACATGCTCTACCCTATACCCGCCAACGCTACCAACGTGCCCA 
               
               
                   
                   
                 TATCCATCCCCTCCCGCAACTGGGCGGCTTTCCGCGGCTGGGCCTTCACGCGCCTT 
               
               
                   
                   
                 AAGACTAAGGAAACCCCATCACTGGGCTCGGGCTACGACCCTTATTACACCTACTCT 
               
               
                   
                   
                 GGCTCTATACCCTACCTAGATGGAACCTTTTACCTCAACCACACCTTTAAGAAGGTG 
               
               
                   
                   
                 GCCATTACCTTTGACTCTTCTGTCAGCTGGCCTGGCAATGACCGCCTGCTTACCCCC 
               
               
                   
                   
                 AACGAGTTTGAAATTAAGCGCTCAGTTGACGGGGAGGGTTACAACGTTGCCCAGTG 
               
               
                   
                   
                 TAACATGACCAAAGACTGGTTCCTGGTACAAATGCTAGCTAACTACAACATTGGCTA 
               
               
                   
                   
                 CCAGGGCTTCTATATCCCAGAGAGCTACAAGGACCGCATGTACTCCTTCTTTAGAAA 
               
               
                   
                   
                 CTTCCAGCCCATGAGCCGTCAGGTGGTGGATGATACTAAATACAAGGACTACCAACA 
               
               
                   
                   
                 GGTGGGCATCCTACACCAACACAACAACTCTGGATTTGTTGGCTACCTTGCCCCCAC 
               
               
                   
                   
                 CATGCGCGAAGGACAGGCCTACCCTGCTAACTTCCCCTATCCGCTTATAGGCAAGA 
               
               
                   
                   
                 CCGCAGTTGACAGCATTACCCAGAAAAAGTTTCTTTGCGATCGCACCCTTTGGCGCA 
               
               
                   
                   
                 TCCCATTCTCCAGTAACTTTATGTCCATGGGCGCACTCACAGACCTGGGCCAAAACC 
               
               
                   
                   
                 TTCTCTACGCCAACTCCGCCCACGCGCTAGACATGACTTTTGAGGTGGATCCCATGG 
               
               
                   
                   
                 ACGAGCCCACCCTTCTTTATGTTTTGTTTGAAGTCTTTGACGTGGTCCGTGTGCACC 
               
               
                   
                   
                 GGCCGCACCGCGGCGTCATCGAAACCGTGTACCTGCGCACGCCCTTCTCGGCCGG 
               
               
                   
                   
                 CAACGCCACAACATAAAGAAGCAAGCAACATCAACAACAGCTGCCGCCATGGGCTC 
               
               
                   
                   
                 CAGTGAGCAGGAACTGAAAGCCATTGTCAAAGATCTTGGTTGTGGGCCATATTTTTT 
               
               
                   
                   
                 GGGCACCTATGACAAGCGCTTTCCAGGCTTTGTTTCTCCACACAAGCTCGCCTGCG 
               
               
                   
                   
                 CCATAGTCAATACGGCCGGTCGCGAGACTGGGGGCGTACACTGGATGGCCTTTGCC 
               
               
                   
                   
                 TGGAACCCGCACTCAAAAACATGCTACCTCTTTGAGCCCTTTGGCTTTTCTGACCAG 
               
               
                   
                   
                 CGACTCAAGCAGGTTTACCAGTTTGAGTACGAGTCACTCCTGCGCCGTAGCGCCATT 
               
               
                   
                   
                 GCTTCTTCCCCCGACCGCTGTATAACGCTGGAAAAGTCCACCCAAAGCGTACAGGG 
               
               
                   
                   
                 GCCCAACTCGGCCGCCTGTGGACTATTCTGCTGCATGTTTCTCCACGCCTTTGCCAA 
               
               
                   
                   
                 CTGGCCCCAAACTCCCATGGATCACAACCCCACCATGAACCTTATTACCGGGGTACC 
               
               
                   
                   
                 CAACTCCATGCTCAACAGTCCCCAGGTACAGCCCACCCTGCGTCGCAACCAGGAAC 
               
               
                   
                   
                 AGCTCTACAGCTTCCTGGAGCGCCACTCGCCCTACTTCCGCAGCCACAGTGCGCAG 
               
               
                   
                   
                 ATTAGGAGCGCCACTTCTTTTTGTCACTTGAAAAACATGTAAAAATAATGTACTAGAG 
               
               
                   
                   
                 ACACTTTCAATAAAGGCAAATGCTTTTATTTGTACACTCTCGGGTGATTATTTACCCC 
               
               
                   
                   
                 CACCCTTGCCGTCTGCGCCGTTTAAAAATCAAAGGGGTTCTGCCGCGCATCGCTAT 
               
               
                   
                   
                 GCGCCACTGGCAGGGACACGTTGCGATACTGGTGTTTAGTGCTCCACTTAAACTCA 
               
               
                   
                   
                 GGCACAACCATCCGCGGCAGCTCGGTGAAGTTTTCACTCCACAGGCTGCGCACCAT 
               
               
                   
                   
                 CACCAACGCGTTTAGCAGGTCGGGCGCCGATATCTTGAAGTCGCAGTTGGGGCCTC 
               
               
                   
                   
                 CGCCCTGCGCGCGCGAGTTGCGATACACAGGGTTGCAGCACTGGAACACTATCAGC 
               
               
                   
                   
                 GCCGGGTGGTGCACGCTGGCCAGCACGCTCTTGTCGGAGATCAGATCCGCGTCCA 
               
               
                   
                   
                 GGTCCTCCGCGTTGCTCAGGGCGAACGGAGTCAACTTTGGTAGCTGCCTTCCCAAA 
               
               
                   
                   
                 AAGGGCGCGTGCCCAGGCTTTGAGTTGCACTCGCACCGTAGTGGCATCAAAAGGTG 
               
               
                   
                   
                 ACCGTGCCCGGTCTGGGCGTTAGGATACAGCGCCTGCATAAAAGCCTTGATCTGCT 
               
               
                   
                   
                 TAAAAGCCACCTGAGCCTTTGCGCCTTCAGAGAAGAACATGCCGCAAGACTTGCCG 
               
               
                   
                   
                 GAAAACTGATTGGCCGGACAGGCCGCGTCGTGCACGCAGCACCTTGCGTCGGTGTT 
               
               
                   
                   
                 GGAGATCTGCACCACATTTCGGCCCCACCGGTTCTTCACGATCTTGGCCTTGCTAGA 
               
               
                   
                   
                 CTGCTCCTTCAGCGCGCGCTGCCCGTTTTCGCTCGTCACATCCATTTCAATCACGTG 
               
               
                   
                   
                 CTCCTTATTTATCATAATGCTTCCGTGTAGACACTTAAGCTCGCCTTCGATCTCAGCG 
               
               
                   
                   
                 CAGCGGTGCAGCCACAACGCGCAGCCCGTGGGCTCGTGATGCTTGTAGGTCACCT 
               
               
                   
                   
                 CTGCAAACGACTGCAGGTACGCCTGCAGGAATCGCCCCATCATCGTCACAAAGGTC 
               
               
                   
                   
                 TTGTTGCTGGTGAAGGTCAGCTGCAACCCGCGGTGCTCCTCGTTCAGCCAGGTCTT 
               
               
                   
                   
                 GCATACGGCCGCCAGAGCTTCCACTTGGTCAGGCAGTAGTTTGAAGTTCGCCTTTA 
               
               
                   
                   
                 GATCGTTATCCACGTGGTACTTGTCCATCAGCGCGCGCGCAGCCTCCATGCCCTTC 
               
               
                   
                   
                 TCCCACGCAGACACGATCGGCACACTCAGCGGGTTCATCACCGTAATTTCACTTTCC 
               
               
                   
                   
                 GCTTCGCTGGGCTCTTCCTCTTCCTCTTGCGTCCGCATACCACGCGCCACTGGGTC 
               
               
                   
                   
                 GTCTTCATTCAGCCGCCGCACTGTGCGCTTACCTCCTTTGCCATGCTTGATTAGCAC 
               
               
                   
                   
                 CGGTGGGTTGCTGAAACCCACCATTTGTAGCGCCACATCTTCTCTTTCTTCCTCGCT 
               
               
                   
                   
                 GTCCACGATTACCTCTGGTGATGGCGGGCGCTCGGGCTTGGGAGAAGGGCGCTTC 
               
               
                   
                   
                 TTTTTCTTCTTGGGCGCAATGGCCAAATCCGCCGCCGAGGTCGATGGCCGCGGGCT 
               
               
                   
                   
                 GGGTGTGCGCGGCACCAGCGCGTCTTGTGATGAGTCTTCCTCGTCCTCGGACTCGA 
               
               
                   
                   
                 TACGCCGCCTCATCCGCTTTTTTGGGGGCGCCCGGGGAGGCGGCGGCGACGGGG 
               
               
                   
                   
                 ACGGGGACGACACGTCCTCCATGGTTGGGGGACGTCGCGCCGCACCGCGTCCGCG 
               
               
                   
                   
                 CTCGGGGGTGGTTTCGCGCTGCTCCTCTTCCCGACTGGCCATTTCCTTCTCCTATAG 
               
               
                   
                   
                 GCAGAAAAAGATCATGGAGTCAGTCGAGAAGAAGGACAGCCTAACCGCCCCCTCTG 
               
               
                   
                   
                 AGTTCGCCACCACCGCCTCCACCGATGCCGCCAACGCGCCTACCACCTTCCCCGTC 
               
               
                   
                   
                 GAGGCACCCCCGCTTGAGGAGGAGGAAGTGATTATCGAGCAGGACCCAGGTTTTGT 
               
               
                   
                   
                 AAGCGAAGACGACGAGGACCGCTCAGTACCAACAGAGGATAAAAAGCAAGACCAGG 
               
               
                   
                   
                 ACAACGCAGAGGCAAACGAGGAACAAGTCGGGCGGGGGGACGAAAGGCATGGCGA 
               
               
                   
                   
                 CTACCTAGATGTGGGAGACGACGTGCTGTTGAAGCATCTGCAGCGCCAGTGCGCCA 
               
               
                   
                   
                 TTATCTGCGACGCGTTGCAAGAGCGCAGCGATGTGCCCCTCGCCATAGCGGATGTC 
               
               
                   
                   
                 AGCCTTGCCTACGAACGCCACCTATTCTCACCGCGCGTACCCCCCAAACGCCAAGA 
               
               
                   
                   
                 AAACGGCACATGCGAGCCCAACCCGCGCCTCAACTTCTACCCCGTATTTGCCGTGC 
               
               
                   
                   
                 CAGAGGTGCTTGCCACCTATCACATCTTTTTCCAAAACTGCAAGATACCCCTATCCTG 
               
               
                   
                   
                 CCGTGCCAACCGCAGCCGAGCGGACAAGCAGCTGGCCTTGCGGCAGGGCGCTGTC 
               
               
                   
                   
                 ATACCTGATATCGCCTCGCTCAACGAAGTGCCAAAAATCTTTGAGGGTCTTGGACGC 
               
               
                   
                   
                 GACGAGAAGCGCGCGGCAAACGCTCTGCAACAGGAAAACAGCGAAAATGAAAGTCA 
               
               
                   
                   
                 CTCTGGAGTGTTGGTGGAACTCGAGGGTGACAACGCGCGCCTAGCCGTACTAAAAC 
               
               
                   
                   
                 GCAGCATCGAGGTCACCCACTTTGCCTACCCGGCACTTAACCTACCCCCCAAGGTC 
               
               
                   
                   
                 ATGAGCACAGTCATGAGTGAGCTGATCGTGCGCCGTGCGCAGCCCCTGGAGAGGG 
               
               
                   
                   
                 ATGCAAATTTGCAAGAACAAACAGAGGAGGGCCTACCCGCAGTTGGCGACGAGCAG 
               
               
                   
                   
                 CTAGCGCGCTGGCTTCAAACGCGCGAGCCTGCCGACTTGGAGGAGCGACGCAAAC 
               
               
                   
                   
                 TAATGATGGCCGCAGTGCTCGTTACCGTGGAGCTTGAGTGCATGCAGCGGTTCTTT 
               
               
                   
                   
                 GCTGACCCGGAGATGCAGCGCAAGCTAGAGGAAACATTGCACTACACCTTTCGACA 
               
               
                   
                   
                 GGGCTACGTACGCCAGGCCTGCAAGATCTCCAACGTGGAGCTCTGCAACCTGGTCT 
               
               
                   
                   
                 CCTACCTTGGAATTTTGCACGAAAACCGCCTTGGGCAAAACGTGCTTCATTCCACGC 
               
               
                   
                   
                 TCAAGGGCGAGGCGCGCCGCGACTACGTCCGCGACTGCGTTTACTTATTTCTATGC 
               
               
                   
                   
                 TACACCTGGCAGACGGCCATGGGCGTTTGGCAGCAGTGCTTGGAGGAGTGCAACCT 
               
               
                   
                   
                 CAAGGAGCTGCAGAAACTGCTAAAGCAAAACTTGAAGGACCTATGGACGGCCTTCA 
               
               
                   
                   
                 ACGAGCGCTCCGTGGCCGCGCACCTGGCGGACATCATTTTCCCCGAACGCCTGCTT 
               
               
                   
                   
                 AAAACCCTGCAACAGGGTCTGCCAGACTTCACCAGTCAAAGCATGTTGCAGAACTTT 
               
               
                   
                   
                 AGGAACTTTATCCTAGAGCGCTCAGGAATCTTGCCCGCCACCTGCTGTGCACTTCCT 
               
               
                   
                   
                 AGCGACTTTGTGCCCATTAAGTACCGCGAATGCCCTCCGCCGCTTTGGGGCCACTG 
               
               
                   
                   
                 CTACCTTCTGCAGCTAGCCAACTACCTTGCCTACCACTCTGACATAATGGAAGACGT 
               
               
                   
                   
                 GAGCGGTGACGGTCTACTGGAGTGTCACTGTCGCTGCAACCTATGCACCCCGCACC 
               
               
                   
                   
                 GCTCCCTGGTTTGCAATTCGCAGCTGCTTAACGAAAGTCAAATTATCGGTACCTTTG 
               
               
                   
                   
                 AGCTGCAGGGTCCCTCGCCTGACGAAAAGTCCGCGGCTCCGGGGTTGAAACTCACT 
               
               
                   
                   
                 CCGGGGCTGTGGACGTCGGCTTACCTTCGCAAATTTGTACCTGAGGACTACCACGC 
               
               
                   
                   
                 CCACGAGATTAGGTTCTACGAAGACCAATCCCGCCCGCCAAATGCGGAGCTTACCG 
               
               
                   
                   
                 CCTGCGTCATTACCCAGGGCCACATTCTTGGCCAATTGCAAGCCATCAACAAAGCCC 
               
               
                   
                   
                 GCCAAGAGTTTCTGCTACGAAAGGGACGGGGGGTTTACTTGGACCCCCAGTCCGGC 
               
               
                   
                   
                 GAGGAGCTCAACCCAATCCCCCCGCCGCCGCAGCCCTATCAGCAGCAGCCGCGGG 
               
               
                   
                   
                 CCCTTGCTTCCCAGGATGGCACCCAAAAAGAAGCTGCAGCTGCCGCCGCCACCCAC 
               
               
                   
                   
                 GGACGAGGAGGAATACTGGGACAGTCAGGCAGAGGAGGTTTTGGACGAGGAGGAG 
               
               
                   
                   
                 GAGGACATGATGGAAGACTGGGAGAGCCTAGACGAGGAAGCTTCCGAGGTCGAAG 
               
               
                   
                   
                 AGGTGTCAGACGAAACACCGTCACCCTCGGTCGCATTCCCCTCGCCGGCGCCCCA 
               
               
                   
                   
                 GAAATCGGCAACCGGTTCCAGCATGGCTACAACCTCCGCTCCTCAGGCGCCGCCG 
               
               
                   
                   
                 GCACTGCCCGTTCGCCGACCCAACCGTAGATGGGACACCACTGGAACCAGGGCCG 
               
               
                   
                   
                 GTAAGTCCAAGCAGCCGCCGCCGTTAGCCCAAGAGCAACAACAGCGCCAAGGCTAC 
               
               
                   
                   
                 CGCTCATGGCGCGGGCACAAGAACGCCATAGTTGCTTGCTTGCAAGACTGTGGGGG 
               
               
                   
                   
                 CAACATCTCCTTCGCCCGCCGCTTTCTTCTCTACCATCACGGCGTGGCCTTCCCCCG 
               
               
                   
                   
                 TAACATCCTGCATTACTACCGTCATCTCTACAGCCCATACTGCACCGGCGGCAGCGG 
               
               
                   
                   
                 CAGCGGCAGCAACAGCAGCGGCCACACAGAAGCAAAGGCGACCGGATAGCAAGAC 
               
               
                   
                   
                 TCTGACAAAGCCCAAGAAATCCACAGCGGCGGCAGCAGCAGGAGGAGGAGCGCTG 
               
               
                   
                   
                 CGTCTGGCGCCCAACGAACCCGTATCGACCCGCGAGCTTAGAAACAGGATTTTTCC 
               
               
                   
                   
                 CACTCTGTATGCTATATTTCAACAGAGCAGGGGCCAAGAACAAGAGCTGAAAATAAA 
               
               
                   
                   
                 AAACAGGTCTCTGCGATCCCTCACCCGCAGCTGCCTGTATCACAAAAGCGAAGATCA 
               
               
                   
                   
                 GCTTCGGCGCACGCTGGAAGACGCGGAGGCTCTCTTCAGTAAATACTGCGCGCTGA 
               
               
                   
                   
                 CTCTTAAGGACTAGTTTCGCGCCCTTTCTCAAATTTAAGCGCGAAAACTACGTCATCT 
               
               
                   
                   
                 CCAGCGGCCACACCCGGCGCCAGCACCTGTCGTCAGCGCCATTATGAGCAAGGAA 
               
               
                   
                   
                 ATTCCCACGCCCTACATGTGGAGTTACCAGCCACAAATGGGACTTGCGGCTGGAGC 
               
               
                   
                   
                 TGCCCAAGACTACTCAACCCGAATAAACTACATGAGCGCGGGACCCCACATGATATC 
               
               
                   
                   
                 CCGGGTCAACGGAATCCGCGCCCACCGAAACCGAATTCTCTTGGAACAGGCGGCTA 
               
               
                   
                   
                 TTACCACCACACCTCGTAATAACCTTAATCCCCGTAGTTGGCCCGCTGCCCTGGTGT 
               
               
                   
                   
                 ACCAGGAAAGTCCCGCTCCCACCACTGTGGTACTTCCCAGAGACGCCCAGGCCGAA 
               
               
                   
                   
                 GTTCAGATGACTAACTCAGGGGCGCAGCTTGCGGGCGGCTTTCGTCACAGGGTGC 
               
               
                   
                   
                 GGTCGCCCGGGCAGGGTATAACTCACCTGACAATCAGAGGGCGAGGTATTCAGCTC 
               
               
                   
                   
                 AACGACGAGTCGGTGAGCTCCTCGCTTGGTCTCCGTCCGGACGGGACATTTCAGAT 
               
               
                   
                   
                 CGGCGGCGCCGGCCGCTCTTCATTCACGCCTCGTCAGGCAATCCTAACTCTGCAGA 
               
               
                   
                   
                 CCTCGTCCTCTGAGCCGCGCTCTGGAGGCATTGGAACTCTGCAATTTATTGAGGAGT 
               
               
                   
                   
                 TTGTGCCATCGGTCTACTTTAACCCCTTCTCGGGACCTCCCGGCCACTATCCGGATC 
               
               
                   
                   
                 AATTTATTCCTAACTTTGACGCGGTAAAGGACTCGGCGGATGGCTACGACTGAATGT 
               
               
                   
                   
                 TAAGTGGAGAGGCAGAGCAACTGCGCCTGAAACACCTGGTCCACTGTCGCCGCCAC 
               
               
                   
                   
                 AAGTGCTTTGCCCGCGACTCCGGTGAGTTTTGCTACTTTGAATTGCCCGAGGATCAT 
               
               
                   
                   
                 ATCGAGGGCCCGGCGCACGGCGTCCGGCTTACCGCCCAGGGAGAGCTTGCCCGTA 
               
               
                   
                   
                 GCCTGATTCGGGAGTTTACCCAGCGCCCCCTGCTAGTTGAGCGGGACAGGGGACC 
               
               
                   
                   
                 CTGTGTTCTCACTGTGATTTGCAACTGTCCTAACCCTGGATTACATCAAGATCTTTGT 
               
               
                   
                   
                 TGCCATCTCTGTGCTGAGTATAATAAATACAGAAATTAAAATATACTGGGGCTCCTAT 
               
               
                   
                   
                 CGCCATCCTGTAAACGCCACCGTCTTCACCCGCCCAAGCAAACCAAGGCGAACCTT 
               
               
                   
                   
                 ACCTGGTACTTTTAACATCTCTCCCTCTGTGATTTACAACAGTTTCAACCCAGACGGA 
               
               
                   
                   
                 GTGAGTCTACGAGAGAACCTCTCCGAGCTCAGCTACTCCATCAGAAAAAACACCACC 
               
               
                   
                   
                 CTCCTTACCTGCCGGGAACGTACGACCTAGGGATAACAGGGTAATAAGCAATTGACT 
               
               
                   
                   
                 CTATGTGGGATATGCTCCAGCGCTACAACCTTGAAGTCAGGCTTCCTGGATGTCAGC 
               
               
                   
                   
                 ATCTGACTTTGGCCAGCACCTGTCCCGCGGATTTGTTCCAGTCCAACTACAGCGACC 
               
               
                   
                   
                 CACCCTAACAGAGATGACCAACACAACCAACGCGGCCGCCGCTACCGGACTTACAT 
               
               
                   
                   
                 CTACCACAAATACACCCCAAGTTTCTGCCTTTGTCAATAACTGGGATAACTTGGGCAT 
               
               
                   
                   
                 GTGGTGGTTCTCCATAGCGCTTATGTTTGTATGCCTTATTATTATGTGGCTCATCTGC 
               
               
                   
                   
                 TGCCTAAAGCGCAAACGCGCCCGACCACCCATCTATAGTCCCATCATTGTGCTACAC 
               
               
                   
                   
                 CCAAACAATGATGGAATCCATAGATTGGACGGACTGAAACACATGTTCTTTTCTCTTA 
               
               
                   
                   
                 CAGTATGATTAAATGAGACATGATTCCTCGAGTTTTTATATTACTGACCCTTGTTGCG 
               
               
                   
                   
                 CTTTTTTGTGCGTGCTCCACATTGGCTGCGGTTTCTCACATCGAAGTAGACTGCATT 
               
               
                   
                   
                 CCAGCCTTCACAGTCTATTTGCTTTACGGATTTGTCACCCTCACGCTCATCTGCAGC 
               
               
                   
                   
                 CTCATCACTGTGGTCATCGCCTTTATCCAGTGCATTGACTGGGTCTGTGTGCGCTTT 
               
               
                   
                   
                 GCATATCTCAGACACCATCCCCAGTACAGGGACAGGACTATAGCTGAGCTTCTTAGA 
               
               
                   
                   
                 ATTCTTTAATTATGAAATTTACTGTGACTTTTCTGCTGATTATTTGCACCCTATCTGCG 
               
               
                   
                   
                 TTTTGTTCCCCGACCTCCAAGCCTCAAAGACATATATCATGCAGATTCACTCGTATAT 
               
               
                   
                   
                 GGAATATTCCAAGTTGCTACAATGAAAAAAGCGATCTTTCCGAAGCCTGGTTATATGC 
               
               
                   
                   
                 AATCATCTCTGTTATGGTGTTCTGCAGTACCATCTTAGCCCTAGCTATATATCCCTAC 
               
               
                   
                   
                 CTTGACATTGGCTGGAAACGAATAGATGCCATGAACCACCCAACTTTCCCCGCGCCC 
               
               
                   
                   
                 GCTATGCTTCCACTGCAACAAGTTGTTGCCGGCGGCTTTGTCCCAGCCAATCAGCCT 
               
               
                   
                   
                 CGCCCCACTTCTCCCACCCCCACTGAAATCAGCTACTTTAATCTAACAGGAGGAGAT 
               
               
                   
                   
                 GACTGACACCCTAGATCTAGAAATGGACGGAATTATTACAGAGCAGCGCCTGCTAGA 
               
               
                   
                   
                 AAGACGCAGGGCAGCGGCCGAGCAACAGCGCATGAATCAAGAGCTCCAAGACATG 
               
               
                   
                   
                 GTTAACTTGCACCAGTGCAAAAGGGGTATCTTTTGTCTGGTAAAGCAGGCCAAAGTC 
               
               
                   
                   
                 ACCTACGACAGTAATACCACCGGACACCGCCTTAGCTACAAGTTGCCAACCAAGCGT 
               
               
                   
                   
                 CAGAAATTGGTGGTCATGGTGGGAGAAAAGCCCATTACCATAACTCAGCACTCGGTA 
               
               
                   
                   
                 GAAACCGAAGGCTGCATTCACTCACCTTGTCAAGGACCTGAGGATCTCTGCACCCTT 
               
               
                   
                   
                 ATTAAGACCCTGTGCGGTCTCAAAGATCTTATTCCCTTTAACTAATAAAAAAAAATAAT 
               
               
                   
                   
                 AAAGCATCACTTACTTAAAATCAGTTAGCAAATTTCTGTCCAGTTTATTCAGCAGCAC 
               
               
                   
                   
                 CTCCTTGCCCTCCTCCCAGCTCTGGTATTGCAGCTTCCTCCTGGCTGCAAACTTTCT 
               
               
                   
                   
                 CCACAATCTAAATGGAATGTCAGTTTCCTCCTGTTCCTGTCCATCCGCACCCACTATC 
               
               
                   
                   
                 TTCATGTTGTTGCAGATGAAGCGCGCAAGACCGTCTGAAGATACCTTCAACCCCGTG 
               
               
                   
                   
                 TATCCATATGACACGGAAACCGGTCCTCCAACTGTGCCTTTTCTTACTCCTCCCTTTG 
               
               
                   
                   
                 TATCCCCCAATGGGTTTCAAGAGAGTCCCCCTGGGGTACTCTCTTTGCGCCTATCCG 
               
               
                   
                   
                 AACCTCTAGTTACCTCCAATGGCATGCTTGCGCTCAAAATGGGCAACGGCCTCTCTC 
               
               
                   
                   
                 TGGACGAGGCCGGCAACCTTACCTCCCAAAATGTAACCACTGTGAGCCCACCTCTC 
               
               
                   
                   
                 AAAAAAACCAAGTCAAACATAAACCTGGAAATATCTGCACCCCTCACAGTTACCTCAG 
               
               
                   
                   
                 AAGCCCTAACTGTGGCTGCCGCCGCACCTCTAATGGTCGCGGGCAACACACTCACC 
               
               
                   
                   
                 ATGCAATCACAGGCCCCGCTAACCGTGCACGACTCCAAACTTAGCATTGCCACCCAA 
               
               
                   
                   
                 GGACCCCTCACAGTGTCAGAAGGAAAGCTAGCCCTGCAAACATCAGGCCCCCTCAC 
               
               
                   
                   
                 CACCACCGATAGCAGTACCCTTACTATCACTGCCTCACCCCCTCTAACTACTGCCAC 
               
               
                   
                   
                 TGGTAGCTTGGGCATTGACTTGAAAGAGCCCATTTATACACAAAATGGAAAACTAGG 
               
               
                   
                   
                 ACTAAAGTACGGGGCTCCTTTGCATGTAACAGACGACCTAAACACTTTGACCGTAGC 
               
               
                   
                   
                 AACTGGTCCAGGTGTGACTATTAATAATACTTCCTTGCAAACTAAAGTTACTGGAGCC 
               
               
                   
                   
                 TTGGGTTTTGATTCACAAGGCAATATGCAACTTAATGTAGCAGGAGGACTAAGGATT 
               
               
                   
                   
                 GATTCTCAAAACAGACGCCTTATACTTGATGTTAGTTATCCGTTTGATGCTCAAAACC 
               
               
                   
                   
                 AACTAAATCTAAGACTAGGACAGGGCCCTCTTTTTATAAACTCAGCCCACAACTTGGA 
               
               
                   
                   
                 TATTAACTACAACAAAGGCCTTTACTTGTTTACAGCTTCAAACAATTCCAAAAAGCTTG 
               
               
                   
                   
                 AGGTTAACCTAAGCACTGCCAAGGGGTTGATGTTTGACGCTACAGCCATAGCCATTA 
               
               
                   
                   
                 ATGCAGGAGATGGGCTTGAATTTGGTTCACCTAATGCACCAAACACAAATCCCCTCA 
               
               
                   
                   
                 AAACAAAAATTGGCCATGGCCTAGAATTTGATTCAAACAAGGCTATGGTTCCTAAACT 
               
               
                   
                   
                 AGGAACTGGCCTTAGTTTTGACAGCACAGGTGCCATTACAGTAGGAAACAAAAATAA 
               
               
                   
                   
                 TGATAAGCTAACCCTATGGACAGGTCCAAAACCAGAAGCCAACTGCATAATTGAATA 
               
               
                   
                   
                 CGGGAAACAAAACCCAGATAGCAAACTAACTTTAATCCTTGTAAAAAATGGAGGAATT 
               
               
                   
                   
                 GTTAATGGATATGTAACGCTAATGGGAGCCTCAGACTACGTTAACACCTTATTTAAAA 
               
               
                   
                   
                 ACAAAAATGTCTCCATTAATGTAGAACTATACTTTGATGCCACTGGTCATATATTACCA 
               
               
                   
                   
                 GACTCATCTTCTCTTAAAACAGATCTAGAACTAAAATACAAGCAAACCGCTGACTTTA 
               
               
                   
                   
                 GTGCAAGAGGTTTTATGCCAAGTACTACAGCGTATCCATTTGTCCTTCCTAATGCGG 
               
               
                   
                   
                 GAACACATAATGAAAATTATATTTTTGGTCAATGCTACTACAAAGCAAGCGATGGTGC 
               
               
                   
                   
                 CCTTTTTCCGTTGGAAGTTACTGTTATGCTTAATAAACGCCTGCCAGATAGTCGCACA 
               
               
                   
                   
                 TCCTATGTTATGACTTTTTTATGGTCCTTGAATGCTGGTCTAGCTCCAGAAACTACTC 
               
               
                   
                   
                 AGGCAACCCTCATAACCTCCCCATTTACCTTTTCCTATATTAGAGAAGATGACTAATA 
               
               
                   
                   
                 AACTCTAAAGAATCGTTTGTGTTATGTTTCAACGTGTTTATTTTTCAATTGCAGAAAAT 
               
               
                   
                   
                 TTCAAGTCATTTTTCATTCAGTAGTATAGCCCCACCACCACATAGCTTATACAGATCA 
               
               
                   
                   
                 CCGTACCTTAATCAAACTCACAGAACCCTAGTATTCAACCTGCCACCTCCCTCCCAA 
               
               
                   
                   
                 CACACAGAGTACACAGTCCTTTCTCCCCGGCTGGCCTTAAAAAGCATCATATCATGG 
               
               
                   
                   
                 GTAACAGACATATTCTTAGGTGTTATATTCCACACGGTTTCCTGTCGAGCCAAACGCT 
               
               
                   
                   
                 CATCAAGTGATATTAATAAACTCCCCGGGCAGCTCACTTAAGTTCATGTCGCTGTCC 
               
               
                   
                   
                 AGCTGCTGAGCCACAGGCTGCTGTCCAACTTGCGGTTGCTTAACGGGCGGCGAAG 
               
               
                   
                   
                 GAGAAGTCCACGCCTACATGGGGGGAGAGTCATAATCGTGCATCAGGATAGGGCG 
               
               
                   
                   
                 GTGGTGCTGCAGCAGCGCGCGAATAAACTGCTGCCGCCGCCGCTCCGTCCTGCAG 
               
               
                   
                   
                 GAATACAACATGGCAGTGGTCTCCTCAGCGATGATTCGCACCGCCCGCAGCATAAG 
               
               
                   
                   
                 GCGCTTGTCCTCCGGGCACAGCAGCGCACCCTGATCTCACTTAAATCAGCACAGTA 
               
               
                   
                   
                 ACTGCAGCACAGCACCACAATATTGTTCAAAATCCCACAGTGCAAGGCGCTGTATCC 
               
               
                   
                   
                 AAAGCTCATGGCGGGGACCACAGAACCCACGTGGCCATCATACCACAAGCGCAGGT 
               
               
                   
                   
                 AGATTAAGTGGCGACCCCTCATAAACACGCTGGACATAAACATTACCTCTTTTGGCA 
               
               
                   
                   
                 TGTTGTAATTCACCACCTCCCGGTACCATATAAACCTCTGATTAAACATGGCGCCATC 
               
               
                   
                   
                 CACCACCATCCTAAACCAGCTGGCCAAAACCTGCCCCGCCGGGNTATACACTGCAG 
               
               
                   
                   
                 GGAACCGGGACTTGGACAATGACAAGTGGGAGAGCCCAGGACTCGTAACCATGGAT 
               
               
                   
                   
                 CATCATGCTCGTCATGATATCAATGTTGGCACAACACAGGCACACGTGCATACACTT 
               
               
                   
                   
                 CCTCAGGATTACAAGCTCCTCCCGCGTTAGAACCATATCCCAGGGAACAACCCATTC 
               
               
                   
                   
                 CTGAATCAGCGTAAATCCCACACTGCAGGGAAGACCTCGCACGTAACTCACGTTGT 
               
               
                   
                   
                 GCATTGTCAAAGTGTTACATTCGGGCAGCAGCGGATGATCCTCCAGTATGGTAGCG 
               
               
                   
                   
                 CGGGTTTCTGTCTCAAAAGGAGGTAGACGATCCCTACTGTACGGAGTGCGCCGAGA 
               
               
                   
                   
                 CAACCGAGATCGTGTTGGTCGTAGTGTCATGCCAAATGGAACGCCGGACGTAGTCA 
               
               
                   
                   
                 TATTTCCTGAAGCAAAACCAGGTGCGGGCGTGACAAACAGATCTGCGTCTCCGGTC 
               
               
                   
                   
                 TCGCCGCTTAGATCGCTCTGTGTAGTAGTTGTAGTATATCCACTCTCTCAAAGCATCC 
               
               
                   
                   
                 AGGCGCCCCCTGGCTTCGGGTTCTATGTAAACTCCTTCATGCGCCGCTGCCCTGAT 
               
               
                   
                   
                 AACATCCACCACCGCAGAATAAGCCACACCCAGCCAACCTACACATTCGTTCTGCGA 
               
               
                   
                   
                 GTCACACACGGGAGGAGCGGGAAGAGCTGGAAGAACCATGTTTTTTTTTTTATTCCA 
               
               
                   
                   
                 AAAGATTATCCAAAACCTCAAAATGAAGATCTATTAAGTGAACGCGCTCCCCTCCGG 
               
               
                   
                   
                 TGGCGTGGTCAAACTCTACAGCCAAAGAACAGATAATGGCATTTGTAAGATGTTGCA 
               
               
                   
                   
                 CAATGGCTTCCAAAAGGCAAACGGCCCTCACGTCCAAGTGGACGTAAAGGCTAAAC 
               
               
                   
                   
                 CCTTCAGGGTGAATCTCCTCTATAAACATTCCAGCACCTTCAACCATGCCCAAATAAT 
               
               
                   
                   
                 TCTCATCTCGCCACCTTCTCAATATATCTCTAAGCAAATCCCGAATATTTAAGTCCGG 
               
               
                   
                   
                 GCCATTGTAAAAAATTTGGCTCCAGAGCGCCCTCCACCTTCAGCCTCAAGCAGCGAA 
               
               
                   
                   
                 TCATGATTGCAAAAATTCAGGTTCCTCACAGACCTGTATAAGATTCAAAAGCGGAACA 
               
               
                   
                   
                 TTAACAAAAATACCGCGATCCCGTAGGTCCCTTCGCAGGGCCAGCTGAACATAATCG 
               
               
                   
                   
                 TGCAGGTCTGCACGGACCAGCGCGGCCACTTCCCCGCCAGGAACCATGACAAAAG 
               
               
                   
                   
                 AACCCACACTGATTATGACACGCATACTCGGAGCTATGCTAACCAGCGTAGCCCCGA 
               
               
                   
                   
                 TGTAAGCTTGTTGCATGGGCGGCGATATAAAATGCAAGGTGCTGCTCAAAAAATCAG 
               
               
                   
                   
                 GCAAAGCCTCGCGCAAAAAAGAAAGCACATCGTAGTCATGCTCATGCAGATAAAGG 
               
               
                   
                   
                 CAGGTAAGCTCCGGAACCACCACAGAAAAAGACACCATTTTTCTCTCAAACATGTCT 
               
               
                   
                   
                 GCGGGTTTCTGCATAAACACAAAATAAAATAACAAAAAAACATTTAAACATTAGAAGC 
               
               
                   
                   
                 CTGTCTTACAACAGGAAAAACAACCCTTATAAGCATAAGACGGACTACGGCCATGCC 
               
               
                   
                   
                 GGCGTGACCGTAAAAAAACTGGTCACCGTGATTAAAAAGCACCACCGACAGCTCCT 
               
               
                   
                   
                 CGGTCAGTCCGGAGTCATAATGTAAGACTCGGTAAACACATCAGGTTGATTCACATC 
               
               
                   
                   
                 GGTCAGTGTTAAAAAGCGACCGAAATAGCCNGGGGGAATACAATACCCGCAGGCGT 
               
               
                   
                   
                 AGAGACAACATTACAGCCCCCATAGGAGGTATAACAAAATTAATAGGAGAGAAAAAC 
               
               
                   
                   
                 ACATAAACACCTGAAAAACCCTCCTGCCTAGGCAAAATAGCACCCTCCCGCTCCAGA 
               
               
                   
                   
                 ACAACATACAGCGCTTCCACAGCGGCAGCCATAACAGTCAGCCTTACCAGTAAAAAA 
               
               
                   
                   
                 GAAAACCTATTAAAAAAACACCACTCGACACGGCACCAGCTCAATCAGTCACAGTGT 
               
               
                   
                   
                 AAAAAAGGGCCAAGTGCAGAGCGAGTATATATAGGACTAAAAAATGACGGTAACGGT 
               
               
                   
                   
                 TAAAGTCCACAAAAAACACCCAGAAAACCGCACGCGAACCTACGCCCAGAAACGAA 
               
               
                   
                   
                 AGCCAAAAAACCCACAACTTCCTCAAATCGTCACTTCCGTTTTCCCACGTTACGTCAC 
               
               
                   
                   
                 TTCCCATTTTAAGAAAACTACAATTCCCAACACATACAAGTTACTCCGCCCTAAAACC 
               
               
                   
                   
                 TACGTCACCCGCCCCGTTCCCACGCCCCGCGCCACGTCACAAACTCCACCCCCTCA 
               
               
                   
                   
                 TTATCATATTGGCTTCAATCCAAAATAAGGTATATTATTGATGATGTTAATTAACATGC 
               
               
                   
                   
                 ATGGATCCTCGTCTCGACGATGCCCTTGAGAGCCTTCAACCCAGTCAGCTCCTTCCG 
               
               
                   
                   
                 GTGGGCGCGGGGCATGACTATCGTCGCCGCACTTATGACTGTCTTCTTTATCATGCA 
               
               
                   
                   
                 ACTCGTAGGACAGGTGCCGGCAGCGCTCTGGGTCATTTTCGGCGAGGACCGCTTTC 
               
               
                   
                   
                 GCTGGAGCGCGACGATGATCGGCCTGTCGCTTGCGGTATTCGGAATCTTGCACGCC 
               
               
                   
                   
                 CTCGCTCAAGCCTTCGTCACTGGTCCCGCCACCAAACGTTTCGGCGAGAAGCAGGC 
               
               
                   
                   
                 CATTATCGCCGGCATGGCGGCCGACGCGCTGGGCTACGTCTTGCTGGCGTTCGCG 
               
               
                   
                   
                 ACGCGAGGCTGGATGGCCTTCCCCATTATGATTCTTCTCGCTTCCGGCGGCATCGG 
               
               
                   
                   
                 GATGCCCGCGTTGCAGGCCATGCTGTCCAGGCAGGTAGATGACGACCATCAGGGA 
               
               
                   
                   
                 CAGCTTCAAGGATCGCTCGCGGCTCTTACCAGCCTAACTTCGATCACTGGACCGCT 
               
               
                   
                   
                 GATCGTCACGGCGATTTATGCCGCCTCGGCGAGCACATGGAACGGGTTGGCATGGA 
               
               
                   
                   
                 TTGTAGGCGCCGCCCTATACCTTGTCTGCCTCCCCGCGTTGCGTCGCGGTGCATGG 
               
               
                   
                   
                 AGCCGGGCCACCTCGACCTGAATGGAAGCCGGCGGCACCTCGCTAACGGATTCAC 
               
               
                   
                   
                 CACTCCAAGAATTGGAGCCAATCAATTCTTGCGGAGAACTGTGAATGCGCAAACCAA 
               
               
                   
                   
                 CCCTTGGCAGAACATATCCATCGCGTCCGCCATCTCCAGCAGCCGCACGCGGCGCA 
               
               
                   
                   
                 TCTCGGGCAGCGTTGGGTCCTGGCCACGGGTGCGCATGATCGTGCTCCTGTCGTTG 
               
               
                   
                   
                 AGGACCCGGCTAGGCTGGCGGGGTTGCCTTACTGGTTAGCAGAATGAATCACCGAT 
               
               
                   
                   
                 ACGCGAGCGAACGTGAAGCGACTGCTGCTGCAAAACGTCTGCGACCTGAGCAACAA 
               
               
                   
                   
                 CATGAATGGTCTTCGGTTTCCGTGTTTCGTAAAGTCTGGAAACGCGGAAGTCAGCGC 
               
               
                   
                   
                 CCTGCACCATTATGTTCCGGATCTGCATCGCAGGATGCTGCTGGCTACCCTGTGGA 
               
               
                   
                   
                 ACACCTACATCTGTATTAACGAAGCGCTGGCATTGACCCTGAGTGATTTTTCTCTGGT 
               
               
                   
                   
                 CCCGCCGCATCCATACCGCCAGTTGTTTACCCTCACAACGTTCCAGTAACCGGGCAT 
               
               
                   
                   
                 GTTCATCATCAGTAACCCGTATCGTGAGCATCCTCTCTCGTTTCATCGGTATCATTAC 
               
               
                   
                   
                 CCCCATGAACAGAAATTCCCCCTTACACGGAGGCATCAAGTGACCAAACAGGAAAAA 
               
               
                   
                   
                 ACCGCCCTTAACATGGCCCGCTTTATCAGAAGCCAGACATTAACGCTTCTGGAGAAA 
               
               
                   
                   
                 CTCAACGAGCTGGACGCGGATGAACAGGCAGACATCTGTGAATCGCTTCACGACCA 
               
               
                   
                   
                 CGCTGATGAGCTTTACCGCAGCTGCCTCGCGCGTTTCGGTGATGACGGTGAAAACC 
               
               
                   
                   
                 TCTGACACATGCAGCTCCCGGAGACGGTCACAGCTTGTCTGTAAGCGGATGCCGGG 
               
               
                   
                   
                 AGCAGACAAGCCCGTCAGGGCGCGTCAGCGGGTGTTGGCGGGTGTCGGGGCGCA 
               
               
                   
                   
                 GCCATGACCCAGTCACGTAGCGATAGCGGAGTGTATACTGGCTTAACTATGCGGCA 
               
               
                   
                   
                 TCAGAGCAGATTGTACTGAGAGTGCACCATATGCGGTGTGAAATACCGCACAGATG 
               
               
                   
                   
                 CGTAAGGAGAAAATACCGCATCAGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCT 
               
               
                   
                   
                 GCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATAC 
               
               
                   
                   
                 GGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAG 
               
               
                   
                   
                 CAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCG 
               
               
                   
                   
                 CCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGA 
               
               
                   
                   
                 CAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCT 
               
               
                   
                   
                 GTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGT 
               
               
                   
                   
                 GGCGCTTTCTCAATGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTC 
               
               
                   
                   
                 CAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCG 
               
               
                   
                   
                 GTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAG 
               
               
                   
                   
                 CCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTG 
               
               
                   
                   
                 AAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTG 
               
               
                   
                   
                 CTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACC 
               
               
                   
                   
                 ACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAA 
               
               
                   
                   
                 GGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAA 
               
               
                   
                   
                 AACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCC 
               
               
                   
                   
                 TTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCT 
               
               
                   
                   
                 GACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTT 
               
               
                   
                   
                 CATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTAC 
               
               
                   
                   
                 CATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGAT 
               
               
                   
                   
                 TTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAAC 
               
               
                   
                   
                 TTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTC 
               
               
                   
                   
                 GCCAGTTAATAGTTTGCGCAACGTTGGTTGNNNNNNAAAAAGGATCTTCACCTAGAT 
               
               
                   
                   
                 CCTTTTCACGTAGAAAGCCAGTCCGCAGAAACGGTGCTGACCCCGGATGAATGTCA 
               
               
                   
                   
                 GCTACTGGGCTATCTGGACAAGGGAAAACGCAAGCGCAAAGAGAAAGCAGGTAGCT 
               
               
                   
                   
                 TGCAGTGGGCTTACATGGCGATAGCTAGACTGGGCGGTTTTATGGACAGCAAGCGA 
               
               
                   
                   
                 ACCGGAATTGCCAGCTGGGGCGCCCTCTGGTAAGGTTGGGAAGCCCTGCAAAGTAA 
               
               
                   
                   
                 ACTGGATGGCTTTCTCGCCGCCAAGGATCTGATGGCGCAGGGGATCAAGCTCTGAT 
               
               
                   
                   
                 CAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGG 
               
               
                   
                   
                 TTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAA 
               
               
                   
                   
                 TCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCT 
               
               
                   
                   
                 TTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAAGACGAGGCAGCGC 
               
               
                   
                   
                 GGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTC 
               
               
                   
                   
                 ACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCC 
               
               
                   
                   
                 TGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGC 
               
               
                   
                   
                 GGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGC 
               
               
                   
                   
                 ATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGA 
               
               
                   
                   
                 CGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGAGC 
               
               
                   
                   
                 ATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATAT 
               
               
                   
                   
                 CATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGG 
               
               
                   
                   
                 CGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGC 
               
               
                   
                   
                 GGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCA 
               
               
                   
                   
                 GCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAATTTTGTTAAAATTTTTGT 
               
               
                   
                   
                 TAAATCAGCTCATTTTTTAACCAATAGGCCGAAATCGGCAACATCCCTTATAAATCAA 
               
               
                   
                   
                 AAGAATAGACCGCGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCCACTAT 
               
               
                   
                   
                 TAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGC 
               
               
                   
                   
                 CCACTACGTGAACCATCACCCAAATCAAGTTTTTTGCGGTCGAGGTGCCGTAAAGCT 
               
               
                   
                   
                 CTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTTGACGGGGAAAGCCGGC 
               
               
                   
                   
                 GAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCT 
               
               
                   
                   
                 GGCAAGTGTAGCGGTCACGCTGCGCGTAACCACCACACCCGCGCGCTTAATGCGC 
               
               
                   
                   
                 CGCTACAGGGCGCGTCCATTCGCCATTCAGGATCGAATTAATTCTTAAT 
               
               
                   
               
               
                 128 
                 STAT1 binding 
                 TTCCGGGAA 
               
               
                   
                 site (1) 
                   
               
               
                   
               
               
                 129 
                 STAT1 binding 
                 TTCTCGGAA 
               
               
                   
                 site (2) 
                   
               
               
                   
               
               
                 130 
                 Human CD44v6 
                 MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNST 
               
               
                   
                   
                 LPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFN 
               
               
                   
                   
                 ASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSS 
               
               
                   
                   
                 GSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATIQATPSSTTEETATQKEQW 
               
               
                   
                   
                 FGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHP 
               
               
                   
                   
                 MGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSH 
               
               
                   
                   
                 EGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPV 
               
               
                   
                   
                 TSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEG 
               
               
                   
                   
                 GANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRK 
               
               
                   
                   
                 PSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV 
               
               
                   
               
               
                 131 
                 HER2(FRP5)- 
                 EVQLQQSGPELKKPGETVKISCKASGYPFTNYGMNWVKQAPGQGLKWMGWINTSTGE 
               
               
                   
                 CD28TM, ICD- 
                 STFADDFKGRFDFSLETSANTAYLQINNLKSEDMATYFCARWEVYHGYVPYWGQGTTV 
               
               
                   
                 CD3Z CAR 
                 TVSSGGGGSGGGGSGGGGSDIQLTQSHKFLSTSVGDRVSITCKASQDVYNAVAWYQQ 
               
               
                   
                   
                 KPGQSPKLLIYSASSRYTGVPSRFTGSGSGPDFTFTISSVQAEDLAVYFCQQHFRTPFTF 
               
               
                   
                   
                 GSGTKLEIKEPKSCDKTHTCPTRFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHS 
               
               
                   
                   
                 DYMNMTPRRPGPTRKHYQPYAPPRDFAAYRSRVKFSRSADAPAYQQGQNQLYNELNL 
               
               
                   
                   
                 GRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMAEAYSEIGMKGERR 
               
               
                   
                   
                 RGKGHDGLYQGLSTATKDTYDALHMQALPPR 
               
               
                   
               
            
           
         
       
     
     The disclosure includes the combination of the aspects and preferred features described except where such a combination is clearly impermissible or expressly avoided. 
     The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described. 
     Aspects and embodiments of the present disclosure will now be illustrated, by way of example, with reference to the accompanying figures. Further aspects and embodiments will be apparent to those skilled in the art. All documents mentioned in this text are incorporated herein by reference. 
     Throughout this specification, including the claims which follow, unless the context requires otherwise, the word “comprise,” and variations such as “comprises” and “comprising,” will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps. 
     It must be noted that, as used in the specification and the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise. Ranges may be expressed herein as from “about” one particular value, and/or to “about” another particular value. When such a range is expressed, another embodiment includes from the one particular value and/or to the other particular value. Similarly, when values are expressed as approximations, by the use of the antecedent “about,” it will be understood that the particular value forms another embodiment. 
     Where a nucleic acid sequence in disclosed the reverse complement thereof is also expressly contemplated. 
    
    
     
       BRIEF DESCRIPTION OF THE FIGURES 
       Embodiments and studies illustrating the principles of the disclosure will now be discussed with reference to the accompanying figures. 
         FIG. 1 . Histograms showing HER2 and CD44v6 expression by FaDu cells, FaDu HER2−/−  and FaDu CD44−/−  cells as determined by flow cytometry. 
         FIG. 2 . Histograms showing HER2 and CD44v6 expression by FaDu cells analysed prior to administration to mice, and FaDu cells obtained from lymph nodes at 20 weeks post-administration. 
         FIG. 3 . Bar chart showing in vitro cell killing of FaDu and FaDu CD44−/−  cells by activated T cells (ATCs), either alone (ATC), or in the presence of cell culture supernatant containing anti-CD19 BiTE (ATC+CD19) or cell culture supernatant containing anti-CD44v6 BiTE (ATC+CD44v6). Data are presented as mean±SD (n=4). *P&lt;0.001; **P&lt;0.01. 
         FIGS. 4A to 4C . Histograms, scatterplots and bar chart showing the results of characterisation by flow cytometry of the immune cell population comprising activated T cells (ATCs) used in in vitro analysis of the anti-cancer activity of ATCs in the presence of cell culture supernatant containing anti-CD19 BiTE or cell culture supernatant containing anti-CD44v6 BiTE.  4 A shows CD44v6 expression by different immune cell subsets.  4 B and  4 C show the numbers of the different immune cell subsets following incubation of the population comprising ATCs in the presence of FaDu cells (Control), and in the presence of cell culture supernatant containing anti-CD19 BiTE (CD19 BiTE), or cell culture supernatant containing anti-CD44v6 BiTE (CD44v6 BiTE). Data are presented as mean±SD (n=4). *P&lt;0.001. 
         FIGS. 5A to 5F . Bar charts and images showing the results of in vitro analysis of cell killing and HDAd transgene expression. Firefly luciferase-labelled FaDu and FaDu HER2−/−  cells were infected with HDAdCD44v6BiTE (BiTE), HDAdIL-12_PD-L1 (IL-12_PDL1) or HDAd Trio (Trio). 24 hours post-infection, HER2-specific CAR-T cells were added at an effector:target cell ratio of 1:10. Cell culture supernatant was collected and analysed for IL-12p70 by ELISA and anti-PD-L1 minibody by western blot, and cell viability was evaluated. Results obtained using FaDu cells are shown in  5 A,  5 C and  5 E. Results obtained using FaDu HER2−/−  cells are shown in  5 B,  5 D and  5 F.  5 A and  5 B show IL-12p70 detected in the cell culture supernatant of uninfected cells (Control) or cells infected with the indicated HdAd.  5 C and  5 D show the cell viability of uninfected cells in the absence of co-culture with HER2-specific CAR-T cells (Control), or following co-culture with HER2-specific CAR-T cells (−), and cell viability of cells infected with the indicated HdAd following co-culture with HER2-specific CAR-T cells.  5 E and  5 F show anti-PD-L1 minibody detected in the cell culture supernatant of cells infected with the indicated HdAd. Data are presented as mean±SD (n=4) *P&lt;0.001. 
         FIGS. 6A to 6D . Graphs and bar charts showing the results of in vitro analysis of cell killing and HDAd transgene expression. FaDu and FaDu HER2−/−  cells were infected with Onc.Ad alone, HDAd Trio alone or Onc5/3Ad2E1Δ24+HDAd Trio (CAdTrio), at various different viral particle/cell concentrations. Cell culture supernatant was collected was analysed for IL-12p70 by ELISA, and cell viability was evaluated. Results obtained using FaDu cells are shown in  6 A and  6 C, and results obtained using FaDu HER2−/−  cells are shown in  6 B and  6 D.  6 A and  6 B show the cell viability of cells infected with the indicated virus/combination of viruses, at the indicated viral particle/cell concentrations.  6 C and  6 D show IL-12p70 detected in the cell culture supernatant of cells infected with the indicated virus/combination of viruses. *P&lt;0.001. 
         FIGS. 7A to 7C . Graphs and images showing the results of in vivo analysis of the anti-cancer activity of the combination of HER2-specific CAR-T cell therapy with different OncAd+HDAd combinations in an ectopic FaDu cell-derived model of squamous cell head and neck carcinoma. FaDu cells were transplanted subcutaneously into the right flank of NSG mice, and mice were untreated (Control), or administered with firefly luciferase-labelled HER2-specific CAR-T cells alone (CART), or in combination with Onc5/3Ad2E1Δ24 and HDAdCD44v6BiTE (BiTE+CART), Onc5/3Ad2E1Δ24 and HDAdIL-12 PD-L1 (12_PD+CART) or Onc5/3Ad2E1Δ24 and HDAd Trio (Trio+CART).  7 A shows tumor volumes at the indicated number of days after administration of the OncAd+HDAd combinations.  7 B and  7 C show the total flux (in photons per second; p/s) of ventral surface for mice of the different treatment groups at the indicated number of days after infusion of the CAR-T cells. 
         FIGS. 8A and 8B . Images and graphs showing the results of in vivo analysis of the anti-cancer activity of the combination of HER2-specific CAR-T cell therapy with different OncAd+HDAd combinations in an orthotopic FaDu cell-derived model of squamous cell head and neck carcinoma. Firefly luciferase-labelled FaDu cells were transplanted orthotopically into NSG mice, and mice were untreated, or administered with HER2-specific CAR-T cells alone (CART), or in combination with Onc5/3Ad2E1Δ24 and HDAdIL-12_PD-L1 (12_PDL1+CART) or Onc5/3Ad2E1Δ24 and HDAd Trio (Trio+CART).  8 A and  8 B show the total flux (in photons per second; p/s) of ventral surface for mice of the different treatment groups at the indicated number of days after infusion of the CAR-T cells. 
         FIGS. 9A to 9C . Images and graphs showing the results of in vivo analysis of the anti-cancer activity of the combination of HER2-specific CAR-T cell therapy with different OncAd+HDAd combinations in an orthotopic FaDu cell-derived model of squamous cell head and neck carcinoma. FaDu cells were transplanted orthotopically into NSG mice, and mice were untreated, or administered with firefly luciferase-labelled HER2-specific CAR-T cells alone (CART), or in combination with Onc5/3Ad2E1Δ24 and HDAdIL-12_PD-L1 (12_PDL1+CART) or Onc5/3Ad2E1Δ24 and HDAd Trio (Trio+CART).  9 A and  9 B show the total flux (in photons per second; p/s) of ventral surface for mice of the different treatment groups at the indicated number of days after infusion of the CAR-T cells.  9 C shows percentage of surviving subjects in the different treatment groups at the indicated number of days after infusion of the CAR-T cells. 
         FIG. 10 . Scatterplots and histograms showing the results of characterisation by flow cytometry of firefly luciferase-labelled HER2-specific CAR-T cells prior to infusion, and HER2-specific CAR-T cells obtained from the tongue and lymph nodes of mice at 120 days post-infusion, from mice treated with Onc5/3Ad2E1Δ24 and HDAdIL-12_PD-L1 (12_PDL1) or Onc5/3Ad2E1Δ24 and HDAd Trio (Trio). The CAR-T cells were analysed for CD4, CD8 and CAR expression. 
         FIGS. 11A to 11C . Graphs and images showing the results of in vivo analysis of the anti-cancer activity of HER2-specific CAR-T cell therapy and OncAd+HDAd in an ectopic PC-3 cell-derived model of prostate adenocarcinoma. PC-3 cells were transplanted subcutaneously into the right flank of NSG mice, and mice were untreated (Control), administered with firefly luciferase-labelled HER2-specific CAR-T cells alone (CART), the combination of Onc5/3Ad2E1Δ24 and HDAd Trio (CAdVEC), or firefly luciferase-labelled HER2-specific CAR-T cells in combination with Onc5/3Ad2E1Δ24 and HDAd Trio (CAd+CART; Trio+CART).  11 A shows tumor volumes at the indicated number of days after administration of the OncAd+HDAd combinations.  11 B and  11 C show the total flux (in photons per second; p/s) of ventral surface for mice of the different treatment groups at the indicated number of days after infusion of the CAR-T cells. 
         FIGS. 12A to 12C . Graphs and images showing the results of in vivo analysis of the anti-cancer activity of HER2-specific CAR-T cell therapy and OncAd+HDAd in an ectopic CAPAN-1 cell-derived model of pancreatic adenocarcinoma. CAPAN-1 cells were transplanted subcutaneously into the right flank of NSG mice, and mice were untreated (Control), administered with firefly luciferase-labelled HER2-specific CAR-T cells alone (CART), the combination of Onc5/3Ad2E1Δ24 and HDAd Trio (CAdVEC), or firefly luciferase-labelled HER2-specific CAR-T cells in combination with Onc5/3Ad2E1Δ24 and HDAd Trio (CAd+CART; Trio+CART).  12 A shows tumor volumes at the indicated number of days after administration of the OncAd+HDAd combinations.  12 B and  12 C show the total flux (in photons per second; p/s) of ventral surface for mice of the different treatment groups at the indicated number of days after infusion of the CAR-T cells. 
         FIG. 13 . Bar chart showing the results of in vitro analysis of cell killing of FaDu, FaDu HER2−/−  and FaDu CD44v6−/−  cells in the presence of AdVSTs alone (AdVST), or in the presence of cell culture supernatant containing anti-CD19 BiTE (AdVST+CD19), cell culture supernatant containing anti-HER2 BiTE (AdVST+HER2), cell culture supernatant containing anti-CD44v6 BiTE (AdVST+CD44v6) or cell culture supernatant containing anti-HER2 BiTE and anti-CD44v6 BiTE (AdVST+2×BiTEs). Data are presented as mean±SD (n=5). *P&lt;0.001; **P&lt;0.01. 
     
    
    
     EXAMPLES 
     Example 1: Materials and Methods 
     1.1 Generation of Antigen-Specific CAR-T Cells 
     HER2-binding CAR constructs were prepared. Briefly, DNA encoding scFv (i.e. VL domain and VH domain joined by a linker sequence) for the anti-HER2 antibody clone FRP5 was cloned into a CAR construct backbone comprising a 5′ signal peptide (SP), and CD28 transmembrane (TM) and intracellular domain sequence, with a 3′ CD3 intracellular domain sequence. The encoded CAR is shown in SEQ ID NO:131. 
     HER2 specific CAR-T cells were subsequently generated. Briefly, human PBMCs were isolated from blood samples by Ficoll density gradient centrifugation. Cells were stimulated with anti-CD3(OKT3)/anti-CD28 in the presence of IL-2 to promote T cell activation and proliferation, and the cells were transduced with retrovirus encoding the HER2 CAR construct. T-cells were expanded by culture in the presence of 100 IU/mL recombinant human IL-2, and were frozen at 6 days post-transduction. 
     PSCA-specific CAR-T cells were generated in the same way, using the PCSA-specific CAR construct “2G.CAR.PSCA” described in Watanabe et al., Oncoimmunology (2016) 5(12): e1253656, which is hereby incorporated by reference in its entirety (represented schematically in FIG. 1A of Watanabe et al., Oncoimmunology (2016) 5(12): e1253656). 
     T-cells were thawed and expanded in the presence of 100 IU/mL of recombinant human IL-2 for 5 days and used for in vitro/in vivo experiments and phenotypic analysis. 
     1.2 Helper-Dependent Ad (HDAd) Constructs 
     Novel constructs encoding a helper-dependent adenovirus were prepared using recombinant DNA techniques. 
     HDAdCD19BiTE contains sequence encoding an anti-CD19 bispecific T cell engager (BiTE), which comprises scFv specific for CD19 joined via a linker to scFv specific for CD3 (clone OKT3). The CD19 scFv comprises the VH and VL of clone FMC63. The nucleotide sequence for HDAdCD19BiTE is shown in SEQ ID NO:123, and the encoded BiTE is shown in SEQ ID NO:93. 
     HDAdCD44v6BiTE contains sequence encoding an anti-CD44v6 BiTE, which comprises scFv specific for CD44v6 joined via a linker to scFv specific for CD3 (clone OKT3). The CD44v6 scFv comprises the VH and VL of clone BIWA8 described e.g. in US 2005/0214212 A1. The nucleotide sequence for HDAdCD44v6BiTE is shown in SEQ ID NO:121, and the encoded BiTE is shown in SEQ ID NO:64. 
     HDAdHER2BiTE contains sequence encoding an anti-HER2 BiTE, which comprises scFv specific for HER2 joined via a linker to scFv specific for CD3 (clone OKT3). The HER2 scFv comprises the VH and VL of clone FRP5. The nucleotide sequence for HDAdCD44v6BiTE is shown in SEQ ID NO:122, and the encoded BiTE is shown in SEQ ID NO:83. 
     HDAd Trio contains sequence encoding expression cassettes for (i) an anti-CD44v6 BiTE, which comprises scFv specific for CD44v6 joined via a linker to scFv specific for CD3 (clone OKT3), (ii) human IL-12p70 (sequence encoding alpha and beta chains), and (iii) an anti-PD-L1 minibody derived from YW243.55.570 (atezolizumab). The three coding sequences each have their own polyA signal sequences. The nucleotide sequence for HDAd Trio is shown in SEQ ID NO:125. 
     HD2xBiTEs contains sequence encoding (i) an anti-HER2 BiTE, which comprises scFv specific for HER2 joined via a linker to scFv specific for CD3, and (ii) an anti-CD44v6 BiTE, which comprises scFv specific for CD44v6 joined via a linker to scFv specific for CD3. The anti-HER2 BiTE and anti-CD44v6 BiTE are encoded by the same expression cassette, joined by a T2A autocleavage linker sequence. The nucleotide sequence for HD2xBiTEs is shown in SEQ ID NO:122, and the encoded BiTE is shown in SEQ ID NO:103. 
     HDAdIL-12_TK_PD-L1 contains sequence encoding expression cassettes for (i) human IL-12p70 (sequence encoding alpha and beta chains), (ii) HSV-1 thymidine kinase, and (iii) an anti-PD-L1 minibody (comprising the CDRs of anti-PD-L1 clone H12_gl described e.g. in WO 2016111645 A1). The three coding sequences each have their own polyA signal sequences. The nucleotide sequence for HDAdIL-12_TK_PD-L1 is shown in SEQ ID NO:120. 
     HDAdIL-12_PD-L1 contains sequence encoding human IL-12p70 protein and anti-PD-L1 minibody derived from YW243.55.570 (atezolizumab). The anti-PD-L1 minibody of this construct consists of scFv for YW243.55.570 fused with a hinge, CH2 and CH3 regions of human IgG1 and a C-terminal HA tag (as described e.g. in Tanoue et al. Cancer Res. (2017) 77(8):2040-2051). 
     1.3 OncAd Construct 
     Constructs encoding oncolytic adenovirus were prepared using recombinant DNA techniques. 
     Onc5/3Ad2E1Δ24 (also referred to herein as “Onc5/2E1Δ24”) shown in SEQ ID NO:126 was prepared by using recombinant DNA techniques. Onc5/3Ad2E1Δ24 has a similar structure as Onc5Δ24 disclosed e.g. in Fueyo et al. 2000 Oncogene 19:2-12 (hereby incorporated by reference in its entirety; Onc5Δ24 is also referred to in Fueyo et al. as “Δ24”), but differs in that Onc5/3Ad2E1Δ24 encodes E1A protein from adenovirus type 2 (Ad2) lacking the sequence LTCHEACF (SEQ ID NO:105), rather than E1A protein from adenovirus type 5 (Ad5) lacking the sequence LTCHEACF (SEQ ID NO:105). 
     1.4 CAdTrio and CAdIL-12 PD-L1 
     “CAd Trio” as used in the present Examples refers to the combination of Onc5/3Ad2E1Δ24 (described in Example 1.3) and HDAd Trio described in Example 1.2. 
     “CAdIL-12_PD-L1” as used in the present Examples refers to the combination of Onc5/3Ad2E1Δ24 (described in Example 1.3) and HDAdIL-12_PD-L1 described in Example 1.2. 
     1.5 Cell Lines 
     The following cell lines are used in the experiments described in the present Examples: 
     FaDu—cell line derived from human pharynx squamous cell carcinoma. 
     FaDu CD44−/− —cell line obtained by CRISPR/Cas9-KO modification of FaDu cells to specifically knockout the gene encoding CD44. 
     FaDu HER2−/− —cell line obtained by CRISPR/Cas9-KO modification of FaDu cells to specifically knockout the gene encoding HER2. 
     PC-3—cell line derived from metastatic human prostate adenocarcinoma. 
     CAPAN-1—cell line derived from metastatic human pancreatic adenocarcinoma. 
     1.6 Generation of Activated T Cells (ATCs) 
     Activated T cells (ATCs) were prepared as follows. 
     Anti-CD3 (clone OKT3) and anti-CD28 agonist antibodies were coated onto wells of tissue culture plates by addition of 0.5 ml of 1:1000 dilution of 1 mg/ml antibodies, and incubation for 2-4 hr at 37° C., or at 4° C. overnight. 
     PBMCs were isolated from blood samples obtained from healthy donors according to the standard Ficoll-Paque method. 
     1×10 6  PBMCs (in 2 ml of cell culture medium) were stimulated by culture on the anti-CD3/CD28 agonist antibody-coated plates in CTL cell culture medium (containing 50% Advanced RPMI, 50% Click&#39;s medium, 10% FBS, 1% GlutaMax, 1% Pen/Strep) supplemented with 10 ng/ml IL-7 and 5 ng/ml IL-15. The cells were maintained at 37° C. in a 5% CO2 atmosphere. The next day, 1 ml of the cell culture medium was replaced with fresh CTL medium containing 20 ng/ml IL-7 and 10 ng/ml IL-15. 
     ATCs were maintained in culture, and subsequently harvested and used in experiments or cryopreserved between days 5-7. 
     1.7 Generation of Oncolytic Virus-Specific T Cells 
     Adenovirus-specific T cells (AdVSTs) were prepared as follows. 
     Anti-CD3 (clone OKT3) and anti-CD28 agonist antibodies were coated onto wells of tissue culture plates by addition of 0.5 ml of 1:1000 dilution of 1 mg/ml antibodies, and incubation for 2-4 hr at 37° C., or at 4° C. overnight. 
     PBMCs were isolated from blood samples obtained from healthy donors according to the standard Ficoll-Paque method. 
     1×10 6  PBMCs (in 2 ml of cell culture medium) were stimulated by culture on the anti-CD3/CD28 agonist antibody-coated plates in CTL cell culture medium supplemented with 10 ng/ml IL-7 and 100 ng/ml IL-15. 
     20 μl of a 200-fold dilution of Adenovirus-specific Hexon Pepmix (JPT Cat #PM-HAdV3) or Penton PepMix (JPT Cat #PM-HAdV5) was added to the wells. The cells were maintained at 37° C. in a 5% CO2 atmosphere. After 48 hours cells were fed with CTL medium, with added IL-7 and IL-15 to a final concentration of 10 ng/ml IL-7 and 100 ng/ml IL-15. 
     1.8 Generation of CAR-Expressing Oncolytic Virus-Specific T Cells 
     On day 3, AdVSTs were resuspended at a concentration of 0.125×10 6  cells/ml in CTL cell culture medium containing 10 ng/ml IL-7 and 100 ng/ml IL-15. 
     Retronectin coated plates were prepared by incubation of RetroNectin (Clontech) diluted 1:100 in PBS for 2-4 hr at 37° C., or at 4° C. overnight. The wells were washed with CTL medium, 1 ml of retroviral supernatant of HER2-specific CAR retrovirus was added to wells, and plates were centrifuged at 2000 g for 1.5 hr. At the end of the centrifugation step retroviral supernatant was aspirated, and 2 ml of AdVST suspension (i.e. 0.25×10 6  cells) was added to wells of the plate. Plates were centrifuged at 400 g for 5 min, and incubated at 37° C. in a 5% CO2 atmosphere. 
     After 48 hrs (i.e. on day 6) the cell culture medium was aspirated and replaced with CTL cell culture medium containing 10 ng/ml IL-7 and 100 ng/ml IL-15. 
     On day 9 cells were harvested and used in experiments or cryopreserved, or subjected to a second stimulation to expand CAR-expressing AdVSTs. 
     1.9 Expansion of AdVSTs and CAR-AdVSTs 
     AdVSTs and CAR-expressing AdVSTs were expanded by further stimulations as desired, as follows. 
     Pepmix-pulsed autologous ATCs were used as APCs, and K562cs cells (see e.g. Ngo et al., J Immunother. (2014) 37(4):193-203) were used as costimulatory cells. The final ratio of AdVSTs or CAR-AdVSTs:ATCs:K562cs cells in the stimulation cultures was 1:1:3-5. 
     AdVSTs or CAR-AdVSTs were resuspended to a concentration of 0.2×10 6  cells/ml in CTL medium. 
     1×10 6  ATCs were incubated with 10 μl of 200-fold dilution of Adenovirus-specific Hexon Pepmix (JPT Cat #PM-HAdV3) or Penton PepMix (JPT Cat #PM-HAdV5) at 37° C. for 30 min. The ATCs were subsequently irradiated at 30 Gy and harvested. 3-5×10 6  K562cs cells were irradiated at 100 Gy. 
     The ATCs and K562cs cells were then mixed in a total volume of 5 ml CTL medium, and 20 ng/ml IL-7 and 200 ng/ml IL-15 was added, 1 ml of this mixture was added to wells of a 24 well plate, and 1 ml of AdVST suspension or CAR-AdVST suspension was added to the wells. 
     Cells were maintained at 37° C. in a 5% CO2 atmosphere. After 3-4 days cell culture medium was added as necessary, and after 6-7 days cells the expanded AdVSTs or CAR-AdVSTs were harvested for use in experiments. 
     Example 2: Analysis of CD44v6 and HER2 Expression in Head and Neck Cancer 
     FaDu cells, FaDu CD44−/−  cells and FaDu HER2−/−  cells were analysed for expression of HER2 and CD44v6 by flow cytometry using antibodies specific for the respective targets. 
     The results are shown in  FIG. 1 . FaDu cells were found to express both of HER2 and CD44v6. FaDu CD44−/−  cells were found to express HER2, but did not express CD44v6. FaDu HER2−/−  cells were found to express CD44v6, but did not express HER2. 
     Example 3: Analysis of FaDu Cell Phenotype Following Treatment with HER2-Specific CAR-T Cells and CAd12_PD-L1 
     The phenotype of cells of a FaDu cell-derived xenograft model of squamous cell head and neck cancer was investigated following treatment with CAd12_PD-L1 and HER2-specific CAR-T cells. 
     Briefly, 0.5×10 6  FaDu cells engineered to express firefly luciferase were injected orthotopically into NSG male mice. After 6 days groups of mice were injected intratumorally with 1×10 8  viral particles of CAd12_PD-L1, at a ratio of Onc5/3Ad2E1Δ24:HDAdIL-12_PD-L1 of 1:20; and three days later, mice were injected via the tail vein with HER2-specific CAR-T cells (see Example 1.1). 
     20 weeks post injection FaDu cells were obtained from the lymph node by FACS sorting of luciferase-expressing cells, and analysed by flow cytometry for expression of HER2 and CD44v6. Expression of HER2 and CD44v6 was also analysed in FaDu cells engineered to express firefly luciferase prior to administration. 
     The results are shown in  FIG. 2 . The FaDu cells that persisted following treatment with CAd12_PD-L1 and HER2-specific CAR-T cells did not express HER2, but did express CD44v6. 
     Example 4: T Cell Mediated Cell Killing of Cancer Cells Facilitated by BiTEs Specific for Cancer Cell Antigens 
     Constructs encoding CD19-specific and CD44v6-specific BiTEs were analysed for their ability to promote cell killing of FaDu cells by activated T cells (ATCs). 
     Briefly, FaDu cells were infected with 200 viral particles/cell of HDAdCD19BiTE or HDAdCD44v6BiTE (see Example 1.2) by addition of viral particles to cell culture medium of the cells in culture. Cell culture supernatant was collected at 48 hours post-infection. 
     ATCs (see Example 1.6) were co-cultured with firefly Luciferase (ffLuc)-labelled FaDu cells or FaDu CD44−/−  cells (see Example 1.5) at an effector:target cell ratio of 1:10, in the presence of cell culture supernatant containing CD19-specific BiTE or CD44v6-specific BiTE. 
     After 72 hours, cell killing was analysed by Luciferase assay. Briefly, cells were washed with PBS, and lysis buffer was added. Cell lysates were collected, and the residual cancer cells were determined by measuring ffLuc activity using plate reader. Readings were normalised using the readings for wells containing FaDu cells or FaDu CD44−/− +ATCs without addition of cell culture media containing BiTE (=100% cell viability), and wells lacking cells (=0% cell viability). 
     The results are shown in  FIG. 3 . Culture in the presence of CD44v6-specific BiTE was found to increase the cell killing of FaDu cells substantially more than FaDu CD44−/−  cells. 
     To determine whether circulating CD44v6 BiTE induces “on target, off tumor” toxicity to immune cells in blood, cell culture media containing BiTE was added to PBMCs from healthy donors in culture in vitro. After 72 hours in culture, PBMCs were analysed by flow cytometry. Briefly, cells were stained with antibodies specific for CD3, CD56, CD33, CD14, CD19 in order to permit the delineation of different immune cell subsets within the PBMC population. 
     The results are shown in  FIGS. 4A to 4C . Culture in the presence of CD44v6-specific BiTE was found not to influence affect the numbers of T cells, NK cells, monocytes of B cells. Culture in the presence of CD19-specific BiTE was found not to influence affect the numbers of T cells, NK cells or monocytes, but significantly reduced the number of B cells. 
     Example 5: Characterisation of HDAds In Vitro 
     5.1 Analysis of HDAd Transgene Expression 
     Firefly luciferase-labelled FaDu and FaDu HER2−/−  cells were infected with 200 viral particles/cell with HDAdCD44v6BiTE, HDAdIL-12_PD-L1 or HDAd Trio (see Example 1.2) by addition of viral particles to cell culture medium of the cells in culture. At 24 hours post-infection, HER2-specific CAR-T cells (see Example 1.1) were added at an effector:target cell ratio of 1:10. Cell culture supernatant was collected at 48 hours post-infection. 
     Secretion of IL-12 into the cell culture supernatant was analysed by ELISA, and secretion of anti-PD-L1 minibody was analysed by western blot using an anti-HA antibody (the anti-PD-L1 minibody comprises a C-terminal HA-tag). 
     At 72 hours after initiation of the co-culture, the residual FaDu cells were detected by analysis of firefly luciferase activity. 
     The results are shown in  FIGS. 5A to 5F . 
     IL-12 was detected in the cell culture supernatant of cells infected with HDAdIL-12_PD-L1 or HDAd Trio. Anti-PD-L1 minibody was also detected in the cell culture supernatant of cells infected with HDAdIL-12 PD-L1 or HDAd Trio. 
     The HER2-specific CAR-T cells killed significantly more FaDu cells than FaDu HER2−/−  cells. Cell killing of FaDu cells and FaDu HER2−/−  cells was greater in the presence of CD44v6BiTE. Cell killing of FaDu cells and FaDu HER2−/−  cells was greater in the presence of IL-12 and anti-PD-L1 minibody. Cell killing of FaDu cells and FaDu HER2−/−  cells was greatest in the presence of CD44v6BiTE, IL-12 and anti-PD-L1 minibody. 
     The ability of Onc5/3Ad2E1Δ24 (Onc.Ad), the combination of Onc5/3Ad2E1Δ24+HDAd Trio (referred to in the Figures as “CAd Trio”) and HDAd Trio to cause cell killing of FaDu cells and FaDu HER2−/−  cells was analysed. 
     Briefly, FaDu cells or FaDu HER2−/−  cells were seeded in wells of 96-well plates and infected with Onc.Ad (alone), Onc5/3Ad2E1Δ24+HDAd Trio (at a ratio of Onc5/3Ad2E1Δ24 to HDAd Trio of 1:20) or HDAd Trio (alone) at various different viral particle/cell concentrations. Cells were cultured for 4 days, and then MTS reagents (Promega) were added to each well, with cells being incubated at 37° C. for 2 hours. Live cells were then detected by measuring the absorbance at 490 nm with a plate reader. Readings were normalised using the readings for untreated cells (=100% cell viability), and wells lacking cells (=0% cell viability). 
     Cell culture supernatants from 100 viral particles/cell conditions were also collected and secretion of IL-12 into the cell culture supernatant was analysed by ELISA. 
     The results are shown in  FIGS. 6A to 6D . 
     Example 6: Analysis of the Anticancer Effects of OncAd and HDAds In Vivo 
     6.1 Ectopic FaDu Cell-Derived Model of Squamous Cell Head and Neck Carcinoma 
     FaDu cells were transplanted subcutaneously into the right flank of NSG mice, and mice were untreated (control), or administered with:
         (i) 1×10 8  viral particles of Onc5/3Ad2E1Δ24 and HDAdCD44v6BiTE, at a ratio of Onc5/3Ad2E1Δ24 to HDAdCD44v6BiTE of 1:20 (referred to as “BiTE+CART” in the Figures);   (ii) 1×10 8  viral particles of Onc5/3Ad2E1Δ24 and HDAdIL-12_PD-L1, at a ratio of Onc5/3Ad2E1Δ24 to HDAdIL-12_PD-L1 of 1:20 (referred to as “12_PD+CART” in the Figures); or   (iii) 1×10 8  viral particles of Onc5/3Ad2E1Δ24 and HDAd Trio, at a ratio of Onc5/3Ad2E1Δ24 to HDAd Trio of 1:20 (referred to as “Trio+CART” in the Figures).       

     Three days later, the mice were administered with 1×10 6  firefly luciferase-labelled HER2-specific CAR-T cells. 
     Tumor volumes were measured on days 3, 7, 11, 14 and 21 after viral particle administration. The end point was established at tumor volume of &gt;1,500 mm 3 . The expansion and localisation of the HER-2 specific CAR-T cells was monitored by analysis of luciferase activity by intraperitoneal injection of D-Luciferin (1.5 mg per mouse), and imaging of the mice 10 min later using an IVIS imager (Xenogen). 
     The results are shown in  FIGS. 7A to 7C . 
     The HER2-specific CAR-T cells were shown to localise to the FaDu tumors. 
     6.2 Orthotopic FaDu Cell-Derived Model of Squamous Cell Head and Neck Carcinoma 
     In a first experiment, 0.5×10 6  firefly luciferase-labelled FaDu cells were injected orthotopically into NSG male mice, and six days later mice were untreated, or administered with:
         (i) 1×10 8  viral particles of Onc5/3Ad2E1Δ24 and HDAdIL-12_PD-L1, at a ratio of Onc5/3Ad2E1Δ24 to HDAdIL-12_PD-L1 of 1:20 (referred to as “12_PDL1+CART” in the Figures); or   (ii) 1×10 8  viral particles of Onc5/3Ad2E1Δ24 and HDAd Trio, at a ratio of Onc5/3Ad2E1Δ24 to HDAd Trio of 1:20 (referred to as “Trio+CART” in the Figures).       

     Three days later, the mice were administered with 0.2×10 6  HER2-specific CAR-T cells. 
     Tumors were monitored by analysis of luciferase activity by intraperitoneal injection of D-Luciferin (1.5 mg per mouse), and imaging of the mice 10 min later using an IVIS imager (Xenogen). 
     The results are shown in  FIGS. 8A and 8B . Treatment with the combination of Onc5/3Ad2E1Δ24+HDAd Trio plus HER2-specific CAR-T cells was found to lead to earlier tumor control as compared to treatment with HER2-specific CAR-T cells only, and also as compared to treatment with the combination of Onc5/3Ad2E1Δ24+HDAdIL-12_PD-L1 plus HER2-specific CAR-T cells. 
     In a separate experiment, 0.5×10 6  FaDu cells were injected orthotopically into NSG male mice, and six days later mice were untreated (control), or administered with:
         (i) 1×10 8  viral particles of Onc5/3Ad2E1Δ24 and HDAdIL-12_PD-L1, at a ratio of Onc5/3Ad2E1Δ24 to HDAdIL-12_PD-L1 of 1:20 (referred to as “12_PDL1+CART” in the Figures); or   (ii) 1×10 8  viral particles of Onc5/3Ad2E1Δ24 and HDAd Trio, at a ratio of Onc5/3Ad2E1Δ24 to HDAd Trio of 1:20 (referred to as “Trio+CART” in the Figures).       

     Three days later, the mice were administered with 0.2×10 6  or 1×10 6  firefly luciferase-labelled HER2-specific CAR-T cells. 
     Tumor volumes and survival were monitored over time. The end point was established at tumor volume of &gt;1,500 mm 3 . The expansion and localisation of the HER-2 specific CAR-T cells was monitored by analysis of luciferase activity by intraperitoneal injection of D-Luciferin (1.5 mg per mouse), and imaging of the mice 10 min later using an IVIS imager (Xenogen). 
     The results are shown in  FIGS. 9A to 9C . The combination of Onc5/3Ad2E1Δ24+HDAd Trio was found to restrict CAR-T cell expansion, and attenuate early mouse death. 
     The phenotype of the HER2-specific CAR-T cells was analysed by flow cytometry prior to infusion into mice, and at day 120 after being harvested from the tongue and lymph nodes of mice that had been treated according to (i) or (ii) above. 
     The results are shown in  FIG. 10 . CD4+ CAR-T cells were found to persist more than CD8+ CAR-T cells. 
     Example 7: Analysis of the OncAd and HDAd Trio In Vivo in Prostate and Pancreatic Cancers 
     7.1 Ectopic PC-3 Cell-Derived Model of Prostate Adenocarcinoma 
     4×10 6  PC-3 cells were injected subcutaneously into the right flank of NSG mice, and six days later mice were untreated (control), or administered with:
         (i) 1×10 8  viral particles of Onc5/3Ad2E1Δ24 and HDAd Trio, at a ratio of Onc5/3Ad2E1Δ24 to HDAd Trio of 1:20 (referred to as “CAdVEC” in the Figures).       

     Three days later, the mice were administered with 1×10 6  firefly luciferase-labelled HER2-specific CAR-T cells, or were not administered with luciferase-labelled HER2-specific CAR-T cells. 
     Tumor volumes and survival were monitored over time. The end point was established at tumor volume of &gt;1,500 mm 3 . The expansion and localisation of the HER-2 specific CAR-T cells was monitored by analysis of luciferase activity by intraperitoneal injection of D-Luciferin (1.5 mg per mouse), and imaging of the mice 10 min later using an IVIS imager (Xenogen). 
     The results are shown in  FIGS. 11A to 11C . Treatment with Onc5/3Ad2E1Δ24+HDAd Trio+HER-2 specific CAR-T cells (referred to in the Figures as “CAd+CART”) was found to reduced tumor volumes and increase survival to a greater extent than treatment with Onc5/3Ad2E1Δ24+HDAd Trio (referred to in the Figures as “CAdVEC”), or treatment with HER2-specific CAR-T cells only (referred to in the Figures as “CART”). 
     7.2 Ectopic CAPAN-1 Cell-Derived Model of Pancreatic Adenocarcinoma 
     In a separate experiment, 5×10 6  CAPAN-1 cells were injected subcutaneously into the right flank of NSG mice, and six days later mice were untreated (control), or administered with:
         (i) 1×10 8  viral particles of Onc5/3Ad2E1Δ24 and HDAd Trio, at a ratio of Onc5/3Ad2E1Δ24 to HDAd Trio of 1:20 (referred to as “CAdVEC” in the Figures).       

     Three days later, the mice were administered with 1×10 6  firefly luciferase-labelled PSCA-specific CAR-T cells (see Example 1.1), or were not administered with luciferase-labelled PSCA-specific CAR-T cells. 
     Tumor volumes and survival were monitored over time. The end point was established at tumor volume of &gt;1,500 mm 3 . The expansion and localisation of the PSCA specific CAR-T cells was monitored by analysis of luciferase activity by intraperitoneal injection of D-Luciferin (1.5 mg per mouse), and imaging of the mice 10 min later using an IVIS imager (Xenogen). 
     The results are shown in  FIGS. 12A to 12C . Treatment with Onc5/3Ad2E1Δ24+HDAd Trio+PSCA specific CAR-T cells (referred to in the Figures as “CAd+CART”) was found to reduced tumor volumes and increase survival to a greater extent than treatment with Onc5/3Ad2E1Δ24+HDAd Trio (referred to in the Figures as “CAdVEC”), or treatment with PSCA-specific CAR-T cells only (referred to in the Figures as “CART”). 
     Example 8: Analysis of the Ability of HDAd-Encoded BiTEs to Induce Cell Killing of Cancer Cells by Adenovirus Specific T Cells In Vitro 
     Firefly luciferase-labelled FaDu cells FaDu CD44−/−  cells or FaDu HER2−/−  cells (see Example 1.5) were infected with 100 viral particles/cell of HDAdCD19BiTE, HDAdHER2BiTE, HDAdCD44v6BiTE or HD2xBiTEs (see Example 1.2) by addition of viral particles to cell culture medium of the cells in culture. 
     At 24 hours post-infection, AdVSTs (see Example 1.7) were added at an effector:target cell ratio of 1:10. 
     After 72 hours, cell killing was analysed by Luciferase assay. Briefly, cells were washed with PBS, and lysis buffer was added. Cell lysates were collected, and the residual cancer cells were determined by measuring ffLuc activity using plate reader. Readings were normalised using the readings for wells containing FaDu cells, FaDu CD44−/−  or FaDu HER2−/− +AdVSTs without infection by HDAds (=100% cell viability), and wells lacking cells (=0% cell viability). 
     The results are shown in  FIG. 13 . HER2-specific and CD44v6-specific BiTEs were found to be very effective at inducing cell killing of FaDu cells by AdVSTs, irrespective of adenovirus infection.