Patent Publication Number: US-11648152-B2

Title: Absorbent negative pressure wound therapy dressing

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application is a continuation of U.S. application Ser. No. 16/328,180, filed Feb. 25, 2019, which is a U.S. national stage application of International Patent Application No. PCT/EP2017/071322, filed Aug. 24, 2017, which claims priority to U.S. Provisional Application No. 62/379,667, filed Aug. 25, 2016, which is hereby incorporated by reference in its entirety. 
    
    
     BACKGROUND 
     Technical Field 
     Disclosed embodiments relate generally to the treatment of wounds using negative pressure wound therapy, in particular the prevention of fluid absorption in selected regions of a negative pressure wound therapy dressing. 
     Description of the Related Art 
     The treatment of open or chronic wounds that are too large to spontaneously close or otherwise fail to heal by means of applying negative pressure to the site of the wound is well known in the art. Negative pressure wound therapy (NPWT) systems currently known in the art commonly involve placing a cover that is impermeable or semi-permeable to fluids over the wound, using various means to seal the cover to the tissue of the patient surrounding the wound, and connecting a source of negative pressure (such as a vacuum pump) to the cover in a manner so that negative pressure is created and maintained under the cover. It is believed that such negative pressures promote wound healing by facilitating the formation of granulation tissue at the wound site and assisting the body&#39;s normal inflammatory process while simultaneously removing excess fluid, which may contain adverse cytokines and/or bacteria. However, further improvements in NPWT are needed to fully realize the benefits of treatment. 
     Many different types of wound dressings are known for aiding in NPWT systems. These different types of wound dressings include many different types of materials and layers, for example, gauze, pads, foam pads or multi-layer wound dressings. One example of a multi-layer wound dressing is the PICO dressing, available from Smith &amp; Nephew, which includes a superabsorbent layer beneath a backing layer to provide a canister-less system for treating a wound with NPWT. The wound dressing may be sealed to a suction port providing connection to a length of tubing, which may be used to pump fluid out of the dressing and/or to transmit negative pressure from a pump to the wound dressing. 
     However, in some wound dressings the absorbent layer fills up with fluid in an unpredictable, and often, non-uniform manner. It may be desirable, in some situations, to more easily prevent fluid from reaching certain areas of the wound dressing and/or certain portions of the absorbent layer. Current dressings have limited and/or unsatisfactory methods of controlling fluid paths in the absorbent layer. 
     SUMMARY 
     Embodiments of this disclosure include wound dressing apparatuses and methods of manufacturing and utilizing the same. Particular embodiments are directed to wound dressing apparatuses and methods of using the same having an absorbent area for retaining wound exudate within the wound dressing, and a negative pressure source in fluid communication with the absorbent area. The negative pressure source may be connected to the wound dressing via a connector attached to the wound dressing, or the negative pressure source may be on or within the wound dressing itself. 
     According to some embodiments, there is provided a wound dressing including a wound contact layer configured to be positioned in contact with a wound; a first area over the wound contact layer that includes a lower spacer layer and an absorbent layer; a second area over the wound contact layer that includes an optional plurality of spacer layers and a negative pressure source and/or electronic components positioned within or between the plurality of spacer layers, wherein the first area is positioned adjacent to the second area and separated by a partition, wherein the partition is formed by an epoxy material applied to one or more layers of the first area and/or the second area; and a cover layer configured to cover and form a seal over the wound contact layer, the first area, and the second area. 
     Wound dressing of the preceding paragraph can include one or more of the following features. In some embodiments of a wound dressing, the epoxy material includes a flexible hydrophobic material. In some embodiments of a wound dressing, the epoxy material includes a silicone adhesive. In embodiments, the wound treatment may further include an upper spacer layer configured to cover the first area and the second area and to allow air to be communicated between the first area and second area around the partition. In some embodiments of a wound dressing, the plurality of spacer layers in the second area include a third spacer layer beneath the negative pressure source and/or electronic components and a fourth spacer layer positioned above the negative pressure source and/or electronic components, wherein the fourth spacer layer includes one or more cutouts or recesses configured to receive the negative pressure source and/or electronic components. In embodiments, the wound treatment apparatus may further include one or more user interface components configured to allow a user to operate the negative pressure source and/or electronic components. 
     According to another embodiment there is provided, a wound dressing including a wound contact layer configured to be positioned in contact with a wound; a first area over the wound contact layer that includes a lower spacer layer and an absorbent layer; a second area over the wound contact layer including an optional plurality of layers and a negative pressure source and/or electronic components positioned within or between the plurality of layers, wherein the first area is positioned adjacent to the second area; and wherein one or more layers of the plurality of layers of the second area include a hydrophobic material surrounding the negative pressure source and/or electronic components; and a cover layer configured to cover and form a seal over the wound contact layer, the first area, and the second area. 
     Wound dressings of any of the preceding paragraphs can include one or more of the following features. In some embodiments of a wound dressing, the absorbent layer includes a portion adjacent to the second area and wherein the portion adjacent to the second area includes a hydrophobic material. In certain embodiments, the wound treatment apparatus may further include an upper spacer layer configured to cover the first area and the second area and to allow air to be communicated between the first area and second area. In some embodiments, the wound dressing the plurality of layers in the second area include a third spacer layer beneath the negative pressure source and/or electronic components and a fourth spacer layer positioned above the negative pressure source and/or electronic components, wherein the fourth spacer layer includes one or more cutouts or recesses configured to receive the negative pressure source and/or electronic components. In some embodiments, the wound dressing wherein the plurality of layers in the second area include a third spacer layer beneath the negative pressure source and/or electronic components, wherein the third spacer layer and the lower spacer layer are one continuous layer positioned below the absorbent layer and the negative pressure source and/or electronic components and above the wound contract layer. In embodiments, the wound treatment apparatus may further include one or more user interface components configured to allow a user to operate the negative pressure source and/or electronic components. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG.  1 A  illustrates an embodiment of a negative pressure wound treatment system employing a flexible fluidic connector and a wound dressing capable of absorbing and storing wound exudate. 
         FIG.  1 B  illustrates an embodiment of a negative pressure wound treatment system employing a flexible fluidic connector and a wound dressing capable of absorbing and storing wound exudate. 
         FIG.  2 A  illustrates an embodiment of a negative pressure wound treatment system employing a flexible fluidic connector and a wound dressing capable of absorbing and storing wound exudate. 
         FIG.  2 B  illustrates a cross section of an embodiment of a fluidic connector connected to a wound dressing. 
         FIG.  2 C  illustrates a wound dressing with the pump and/or other electronics positioned away from the wound site according to an embodiment. 
         FIG.  3    is an image of an embodiment of a partially saturated wound dressing, comprising a ring of glue around the distal end of a fluidic connector. 
         FIG.  4    shows multiple images of embodiments of a wound dressing that becomes more saturated with dyed fluid over time. 
         FIG.  5    shows multiple cross-sectional micro-CTs of embodiments of wound dressings with glue on the backing layer. 
         FIG.  6    shows multiple scanning electron microscopy (SEM) micrographs of embodiments of wound dressings with glue on the backing layer. 
         FIG.  7    shows multiple SEM micrographs of embodiments of wound dressings with glue on the backing layer. 
         FIG.  8    shows multiple SEM micrographs of embodiments of wound dressings without glue on the backing layer. 
     
    
    
     DETAILED DESCRIPTION 
     Embodiments disclosed herein relate to apparatuses and methods of treating a wound with reduced pressure, including a source of negative pressure and wound dressing components and apparatuses. The apparatuses and components comprising the wound overlay and packing materials, if any, are sometimes collectively referred to herein as dressings. 
     Some embodiments disclosed herein relate to wound therapy for a human or animal body. Therefore, any reference to a wound herein can refer to a wound on a human or animal body, and any reference to a body herein can refer to a human or animal body. The term “wound” as used herein, in addition to having its broad ordinary meaning, includes any body part of a patient that may be treated using negative pressure. Wounds include, but are not limited to, open wounds, incisions, lacerations, abrasions, contusions, burns, diabetic ulcers, pressure ulcers, stoma, surgical wounds, trauma and venous ulcers or the like. Treatment of such wounds can be performed using negative pressure wound therapy, wherein a reduced or negative pressure can be applied to the wound to facilitate and promote healing of the wound. It will also be appreciated that the fluidic connector and methods as disclosed herein may be applied to other parts of the body, and are not necessarily limited to treatment of wounds. 
     Treatment of such wounds can be performed using negative pressure wound therapy, wherein a reduced or negative pressure can be applied to the wound to facilitate and promote healing of the wound. It will also be appreciated that the wound dressing and methods as disclosed herein may be applied to other parts of the body, and are not necessarily limited to treatment of wounds. Certain embodiments of this application relate to a wound treatment apparatus employing a wound dressing and a fluidic connector, and to methods of using the same. 
     It will be understood that embodiments of the present disclosure are generally applicable to use in topical negative pressure (“TNP”) therapy systems. Briefly, negative pressure wound therapy assists in the closure and healing of many forms of “hard to heal” wounds by reducing tissue oedema; encouraging blood flow and granular tissue formation; removing excess exudate and may reduce bacterial load (and thus infection risk). In addition, the therapy allows for less disturbance of a wound leading to more rapid healing. TNP therapy systems may also assist on the healing of surgically closed wounds by removing fluid and by helping to stabilize the tissue in the apposed position of closure. A further beneficial use of TNP therapy can be found in grafts and flaps where removal of excess fluid is important and close proximity of the graft to tissue is required in order to ensure tissue viability. 
     As is used herein, reduced or negative pressure levels, such as-X mmHg, represent pressure levels relative to normal ambient atmospheric pressure, which can correspond to 760 mmHg (or 1 atm, 29.93 mmHg, 101.325 kPa, 14.696 psi, etc.). Accordingly, a negative pressure value of −X mmHg reflects absolute pressure that is X mmHg below 760 mmHg or, in other words, an absolute pressure of (760−X) mmHg. In addition, negative pressure that is “less” or “smaller” than X mmHg corresponds to pressure that is closer to atmospheric pressure (e.g., −40 mmHg is less than −60 mmHg). Negative pressure that is “more” or “greater” than −X mmHg corresponds to pressure that is further from atmospheric pressure (e.g., −80 mmHg is more than −60 mmHg). In some embodiments, local ambient atmospheric pressure is used as a reference point, and such local atmospheric pressure may not necessarily be, for example, 760 mmHg. 
     The negative pressure range for some embodiments of the present disclosure can be approximately −80 mmHg, or between about −20 mmHg and −200 mmHg Note that these pressures are relative to normal ambient atmospheric pressure, which can be 760 mmHg Thus, −200 mmHg would be about 560 mmHg in practical terms. In some embodiments, the pressure range can be between about −40 mmHg and −150 mmHg. Alternatively a pressure range of up to −75 mmHg, up to −80 mmHg or over −80 mmHg can be used. Also in other embodiments a pressure range of below −75 mmHg can be used. Alternatively, a pressure range of over approximately −100 mmHg, or even−150 mmHg, can be supplied by the negative pressure apparatus. 
       FIGS.  1 A-B  illustrate embodiments of a negative pressure wound treatment system  10  employing a wound dressing  100  in conjunction with a fluidic connector  110 . Here, the fluidic connector  110  may include an elongate conduit, more preferably a bridge  120  having a proximal end  130  and a distal end  140 , and an applicator  180  at the distal end  140  of the bridge  120 . In some embodiments, an optional coupling  160  is preferably disposed at the proximal end  130  of the bridge  120 . A cap  170  may be provided with the system (and can in some cases, as illustrated, be attached to the coupling  160 ). The cap  170  can be useful in preventing fluids from leaking out of the proximal end  130 . The system  10  may include a source of negative pressure such as a pump or negative pressure unit  150  capable of supplying negative pressure. The pump may include a canister or other container for the storage of wound exudates and other fluids that may be removed from the wound. A canister or container may also be provided separate from the pump. In some embodiments, such as illustrated in  FIGS.  1 A- 1 B , the pump  150  can be a canisterless pump such as the PICO™ pump, as sold by Smith &amp; Nephew. The pump  150  may be connected to the coupling  160  via a tube  190 , or the pump  150  may be connected directly to the coupling  160  or directly to the bridge  120 . In use, the dressing  100  is placed over a suitably-prepared wound, which may in some cases be filled with a wound packing material such as foam or gauze. The applicator  180  of the fluidic connector  110  has a sealing surface that is placed over an aperture in the dressing  100  and is sealed to the top surface of the dressing  100 . Either before, during, or after connection of the fluidic connector  110  to the dressing  100 , the pump  150  is connected via the tube  190  to the coupling  160 , or is connected directly to the coupling  160  or to the bridge  120 . The pump is then activated, thereby supplying negative pressure to the wound. Application of negative pressure may be applied until a desired level of healing of the wound is achieved. 
     With reference initially to  FIGS.  2 A-B , treatment of a wound with negative pressure in certain embodiments of the application uses a wound dressing  100  capable of absorbing and storing wound exudate in conjunction with a flexible fluidic connector  110 . In some embodiments, the wound dressing  100  may be substantially similar to wound dressings and have the same or similar components as those described throughout International Patent Publication WO2013175306, WO2014020440, WO02014020443 and U.S. Publication No. 2011/0282309 A1, which are incorporated by reference in their entireties. In other embodiments (not shown), the wound dressing may simply include one or more backing layers configured to form a sealed chamber over the wound site. In some embodiments, it may be preferable for the wound site to be filled partially or completely with a wound packing material. This wound packing material is optional, but may be desirable in certain wounds, for example deeper wounds. The wound packing material can be used in addition to the wound dressing  100 . The wound packing material generally may include a porous and conformable material, for example foam (including reticulated foams), and gauze. In some embodiments, preferably, the wound packing material is sized or shaped to fit within the wound site so as to fill any empty spaces. The wound dressing  100  may then be placed over the wound site and wound packing material overlying the wound site. When a wound packing material is used, once the wound dressing  100  is sealed over the wound site, negative pressure may be transmitted from a pump or other source of negative pressure through a flexible tubing via the fluidic connector  110  to the wound dressing  100 , through the wound packing material, and finally to the wound site. This negative pressure draws wound exudate and other fluids or secretions away from the wound site. 
     As shown in the embodiment of  FIG.  2 A , the fluidic connector  110  preferably includes an enlarged distal end, or head  140  that is in fluidic communication with the dressing  100  as will be described in further detail below. In one embodiment, the enlarged distal end has a round or circular shape. The head  140  is illustrated here as being positioned near an edge of the dressing  100 , but may also be positioned at any location on the dressing. For example, some embodiments may provide for a centrally or off-centered location not on or near an edge or corner of the dressing  100 . In some embodiments, the dressing  10  may include two or more fluidic connectors  110 , each comprising one or more heads  140 , in fluidic communication therewith. In some embodiments, the head  140  may preferably measure 30 mm along its widest edge. The head  140  forms at least in part the applicator  180 , described above, that is configured to seal against a top surface of the wound dressing. 
       FIG.  2 B  illustrates a cross-section through a wound dressing  100  similar to the wound dressing  10  as shown in  FIG.  1 B  and described in International Patent Publication WO2013175306, which is incorporated by reference in its entirety, along with fluidic connector  110 . The wound dressing  100 , which can alternatively be any wound dressing embodiment disclosed herein or any combination of features of any number of wound dressing embodiments disclosed herein, can be located over a wound site to be treated. The dressing  100  may be placed so as to form a sealed cavity over the wound site. In a some embodiments, the dressing  100  preferably includes a top or cover layer, or backing layer  220  attached to an optional wound contact layer  222 , both of which are described in greater detail below. These two layers  220 ,  222  are preferably joined or sealed together so as to define an interior space or chamber. This interior space or chamber may include additional structures that may be adapted to distribute or transmit negative pressure, store wound exudate and other fluids removed from the wound, and other functions which will be explained in greater detail below. Examples of such structures, described below, include a transmission layer  226  and an absorbent layer  221 . 
     As illustrated in  FIG.  2 B , the wound contact layer  222  can be a polyurethane layer or polyethylene layer or other flexible layer which is perforated, for example via a hot pin process, laser ablation process, ultrasound process or in some other way or otherwise made permeable to liquid and gas. The wound contact layer  222  has a lower surface  224  and an upper surface  223 . In some embodiments, the perforations  225  preferably include through holes in the wound contact layer  222  which enable fluid to flow through the layer  222 . The wound contact layer  222  helps prevent tissue ingrowth into the other material of the wound dressing. In certain embodiments, preferably, the perforations are small enough to meet this requirement while still allowing fluid to flow therethrough. For example, perforations formed as slits or holes having a size ranging from 0.025 mm to 1.2 mm are considered small enough to help prevent tissue ingrowth into the wound dressing while allowing wound exudate to flow into the dressing. In some configurations, the wound contact layer  222  may help maintain the integrity of the entire dressing  100  while also creating an air tight seal around the absorbent pad in order to maintain negative pressure at the wound. 
     Some embodiments of the wound contact layer  222  may also act as a carrier for an optional lower and upper adhesive layer (not shown). For example, a lower pressure sensitive adhesive may be provided on the lower surface  224  of the wound dressing  100  whilst an upper pressure sensitive adhesive layer may be provided on the upper surface  223  of the wound contact layer. The pressure sensitive adhesive, which may be a silicone, hot melt, hydrocolloid or acrylic based adhesive or other such adhesives, may be formed on both sides or optionally on a selected one or none of the sides of the wound contact layer. When a lower pressure sensitive adhesive layer is utilized may be helpful to adhere the wound dressing  100  to the skin around a wound site. In some embodiments, the wound contact layer may include perforated polyurethane film. The lower surface of the film may be provided with a silicone pressure sensitive adhesive and the upper surface may be provided with an acrylic pressure sensitive adhesive, which may help the dressing maintain its integrity. In some embodiments, a polyurethane film layer may be provided with an adhesive layer on both its upper surface and lower surface, and all three layers may be perforated together. 
     A layer  226  of porous material can be located above the wound contact layer  222 . This porous layer, or transmission layer,  226  allows transmission of fluid including liquid and gas away from a wound site into upper layers of the wound dressing. In certain embodiments, the transmission layer  226  preferably ensures that an open air channel can be maintained to communicate negative pressure over the wound area even when the absorbent layer has absorbed substantial amounts of exudates. The layer  226  should preferably remain open under the typical pressures that will be applied during negative pressure wound therapy as described above, so that the whole wound site sees an equalized negative pressure. The layer  226  may be formed of a material having a three dimensional structure. For example, a knitted or woven spacer fabric (for example Baltex 7970 weft knitted polyester) or a non-woven fabric could be used. 
     In some embodiments, the transmission layer  226  includes a 3D polyester spacer fabric layer including a top layer (that is to say, a layer distal from the wound-bed in use) which is a 84/144 textured polyester, and a bottom layer (that is to say, a layer which lies proximate to the wound bed in use) which is a 10 denier flat polyester and a third layer formed sandwiched between these two layers which is a region defined by a knitted polyester viscose, cellulose or the like monofilament fiber. Other materials and other linear mass densities of fiber could of course be used. 
     Whilst reference is made throughout this disclosure to a monofilament fiber it will be appreciated that a multistrand alternative could of course be utilized. The top spacer fabric thus has more filaments in a yarn used to form it than the number of filaments making up the yarn used to form the bottom spacer fabric layer. 
     This differential between filament counts in the spaced apart layers helps control moisture flow across the transmission layer. Particularly, by having a filament count greater in the top layer, that is to say, the top layer is made from a yarn having more filaments than the yarn used in the bottom layer, liquid tends to be wicked along the top layer more than the bottom layer. In use, this differential tends to draw liquid away from the wound bed and into a central region of the dressing where the absorbent layer  221  helps lock the liquid away or itself wicks the liquid onwards towards the cover layer where it can be transpired. 
     In some embodiments, preferably, to improve the liquid flow across the transmission layer  226  (that is to say perpendicular to the channel region formed between the top and bottom spacer layers) the 3D fabric may be treated with a dry cleaning agent (such as, but not limited to, Perchloro Ethylene) to help remove any manufacturing products such as mineral oils, fats and/or waxes used previously which might interfere with the hydrophilic capabilities of the transmission layer. In some embodiments, an additional manufacturing step can subsequently be carried in which the 3D spacer fabric is washed in a hydrophilic agent (such as, but not limited to, Feran Ice 30 g/l available from the Rudolph Group). This process step helps ensure that the surface tension on the materials is so low that liquid such as water can enter the fabric as soon as it contacts the 3D knit fabric. This also aids in controlling the flow of the liquid insult component of any exudates. 
     A layer  221  of absorbent material is provided above the transmission layer  226 . The absorbent material, which include a foam or non-woven natural or synthetic material, and which may optionally include a super-absorbent material, forms a reservoir for fluid, particularly liquid, removed from the wound site. In some embodiments, the layer  10  may also aid in drawing fluids towards the backing layer  220 . 
     The material of the absorbent layer  221  may also prevent liquid collected in the wound dressing  100  from flowing freely within the dressing. In some embodiments, the material of the absorbent layer  221  preferably acts so as to contain any liquid collected within the dressing. The absorbent layer  221  also helps distribute fluid throughout the layer via a wicking action so that fluid is drawn from the wound site and stored throughout the absorbent layer. This helps prevent agglomeration in areas of the absorbent layer. The capacity of the absorbent material must be sufficient to manage the exudate flow rate of a wound when negative pressure is applied. Since in use the absorbent layer experiences negative pressures the material of the absorbent layer is chosen to absorb liquid under such circumstances. A number of materials exist that are able to absorb liquid when under negative pressure, for example super absorber material. The absorbent layer  221  may typically be manufactured from ALLEVYN™ foam, Freudenberg 114-224-4 and/or Chem-Posite™ 11C-450. In some embodiments, the absorbent layer  221  may include a composite comprising super absorbent powder, fibrous material such as cellulose, and bonding fibers. In certain embodiments, a preferred composite is an airlaid, thermally-bonded composite. 
     In some embodiments, the absorbent layer  221  is a layer of non-woven cellulose fibers having super-absorbent material in the form of dry particles dispersed throughout. Use of the cellulose fibers introduces fast wicking elements which help quickly and evenly distribute liquid taken up by the dressing. The juxtaposition of multiple strand-like fibers leads to strong capillary action in the fibrous pad which helps distribute liquid. In this way, the super-absorbent material is efficiently supplied with liquid. The wicking action also assists in bringing liquid into contact with the upper cover layer to aid increase transpiration rates of the dressing. 
     In some embodiments, an aperture, hole, or orifice  227  is preferably provided in the backing layer  220  to allow a negative pressure to be applied to the dressing  100 . In certain embodiments, the fluidic connector  110  is preferably attached or sealed to the top of the backing layer  220  over the orifice  227  made into the dressing  100 , and communicates negative pressure through the orifice  227 . A length of tubing may be coupled at a first end to the fluidic connector  110  and at a second end to a pump unit (not shown) to allow fluids to be pumped out of the dressing. Where the fluidic connector is adhered to the top layer of the wound dressing, a length of tubing may be coupled at a first end of the fluidic connector such that the tubing, or conduit, extends away from the fluidic connector parallel or substantially to the top surface of the dressing. The fluidic connector  110  may be adhered and sealed to the backing layer  220  using an adhesive such as an acrylic, cyanoacrylate, epoxy, UV curable or hot melt adhesive. The fluidic connector  110  may be formed from a soft polymer, for example a polyethylene, a polyvinyl chloride, a silicone or polyurethane having a hardness of 30 to 90 on the Shore A scale. In some embodiments, the fluidic connector  110  may be made from a soft or conformable material. 
     In some embodiments, the absorbent layer  221  includes at least one through hole  228  located so as to underlie the fluidic connector  110 . The through hole  228  may in some embodiments be the same size as the opening  227  in the backing layer, or may be bigger or smaller. As illustrated in  FIG.  2 B  a single through hole can be used to produce an opening underlying the fluidic connector  110 . It will be appreciated that multiple openings could alternatively be utilized. Additionally should more than one port be utilized according to certain embodiments of the present disclosure one or multiple openings may be made in the absorbent layer and the obscuring layer in registration with each respective fluidic connector. Although not essential to certain embodiments of the present disclosure the use of through holes in the super-absorbent layer may provide a fluid flow pathway which remains unblocked in particular when the absorbent layer is near saturation. 
     The aperture or through-hole  228  can be provided in the absorbent layer  221  beneath the orifice  227  such that the orifice is connected directly to the transmission layer  226 . This allows the negative pressure applied to the fluidic connector  110  to be communicated to the transmission layer  226  without passing through the absorbent layer  221 . This ensures that the negative pressure applied to the wound site is not inhibited by the absorbent layer as it absorbs wound exudates. In other embodiments, no aperture may be provided in the absorbent layer  221 , or alternatively a plurality of apertures underlying the orifice  227  may be provided. In further alternative embodiments, additional layers such as another transmission layer or an obscuring layer such as described in International Patent Publication WO2014020440 may be provided over the absorbent layer  221  and beneath the backing layer  220 . 
     In some embodiments, the backing layer  220  is preferably gas impermeable, but moisture vapor permeable, and can extend across the width of the wound dressing  100 . The backing layer  220 , which may for example be a polyurethane film (for example, Elastollan SP9109) having a pressure sensitive adhesive on one side, is impermeable to gas and this layer thus operates to cover the wound and to seal a wound cavity over which the wound dressing is placed. In this way an effective chamber is made between the backing layer  220  and a wound site where a negative pressure can be established. In certain embodiments, the backing layer  220  is preferably sealed to the wound contact layer  222  in a border region around the circumference of the dressing, ensuring that no air is drawn in through the border area, for example via adhesive or welding techniques. The backing layer  220  protects the wound from external bacterial contamination (bacterial barrier) and allows liquid from wound exudates to be transferred through the layer and evaporated from the film outer surface. In some implementations, the backing layer  220  preferably includes two layers; a polyurethane film and an adhesive pattern spread onto the film. In certain embodiments, the polyurethane film is preferably moisture vapor permeable and may be manufactured from a material that has an increased water transmission rate when wet. In some embodiments the moisture vapor permeability of the backing layer increases when the backing layer becomes wet. The moisture vapor permeability of the wet backing layer may be up to about ten times more than the moisture vapor permeability of the dry backing layer. 
     The absorbent layer  221  may be of a greater area than the transmission layer  226 , such that the absorbent layer overlaps the edges of the transmission layer  226 , thereby ensuring that the transmission layer does not contact the backing layer  220 . This provides an outer channel of the absorbent layer  221  that is in direct contact with the wound contact layer  222 , which aids more rapid absorption of exudates to the absorbent layer. Furthermore, this outer channel ensures that no liquid is able to pool around the circumference of the wound cavity, which may otherwise seep through the seal around the perimeter of the dressing leading to the formation of leaks. In some embodiments, the transmission layer  226  can be a greater area than the absorbent layer  221 , such that the transmission layer  226  extends beyond the edges of the absorbent layer  221 . The dressing can include one or more transmission layers positioned above or below the absorbent layer. As illustrated in  FIGS.  2 A- 2 B , the absorbent layer  221  may define a smaller perimeter than that of the backing layer  220 , such that a boundary or border region is defined between the edge of the absorbent layer  221  and the edge of the backing layer  220 . 
     As shown in  FIG.  2 B , one embodiment of the wound dressing  100  includes an aperture  228  in the absorbent layer  221  situated underneath the fluidic connector  110 . In use, for example when negative pressure is applied to the dressing  100 , a wound facing portion of the fluidic connector may thus come into contact with the transmission layer  226 , which can thus aid in transmitting negative pressure to the wound site even when the absorbent layer  221  is filled with wound fluids. Some embodiments may have the backing layer  220  be at least partly adhered to the transmission layer  226 . In some embodiments, the aperture  228  is at least 1-2 mm larger than the diameter of the wound facing portion of the fluidic connector  11 , or the orifice  227 . 
     In particular for some embodiments with a single fluidic connector  110  and through hole, it may be preferable for the fluidic connector  110  and through hole to be located in an off-center position as illustrated in  FIG.  2 A . Such a location may permit the dressing  100  to be positioned onto a patient such that the fluidic connector  110  is raised in relation to the remainder of the dressing  100 . So positioned, the fluidic connector  110  and the filter  214  may be less likely to come into contact with wound fluids that could prematurely occlude the filter  214  so as to impair the transmission of negative pressure to the wound site. 
     Turning now to the fluidic connector  110 , some embodiments preferably include a sealing surface  216 , a bridge  211  (corresponding to bridge  120  in  FIGS.  1 A- 1 B ) with a proximal end  130  and a distal end  140 , and a filter  214 . In certain embodiments, the sealing surface  216  preferably forms the applicator previously described that is sealed to the top surface of the wound dressing. In some embodiments a bottom layer of the fluidic connector  110  may include the sealing surface  216 , such as layer  540  in  FIG.  5 C  below. The fluidic connector  110  may further include an upper surface vertically spaced from the sealing surface  216 , which in some embodiments is defined by a separate upper layer of the fluidic connector such as layer  510  in  FIG.  5 C  below. In other embodiments the upper surface and the lower surface may be formed from the same piece of material. In some embodiments the sealing surface  216  may include at least one aperture  229  therein to communicate with the wound dressing. In some embodiments the filter  214  may be positioned across the opening  229  in the sealing surface, and may span the entire opening  229 . The sealing surface  216  may be configured for sealing the fluidic connector to the cover layer of the wound dressing, and may include an adhesive or weld. In some embodiments, the sealing surface  216  may be placed over an orifice in the cover layer. In some embodiments, the sealing surface  216  may be positioned over an orifice in the cover layer and an aperture in the absorbent layer  220 , permitting the fluidic connector  110  to provide air flow through the transmission layer  226 . In some embodiments, the bridge  211  may include a first fluid passage  212  in communication with a source of negative pressure, the first fluid passage  212  comprising a porous material, such as a 3D knitted material, which may be the same or different than the porous layer  226  described previously. In some embodiments, the bridge  211  is preferably encapsulated by at least one flexible film layer  208 ,  210  having a proximal and distal end and configured to surround the first fluid passage  212 , the distal end of the flexible film being connected the sealing surface  216 . The filter  214  is configured to substantially prevent wound exudate from entering the bridge. These elements will be described in greater detail below. 
     Some embodiments may further include an optional second fluid passage positioned above the first fluid passage  212 . For example, some embodiments may provide for an air leak may be disposed at the proximal end of the top layer that is configured to provide an air path into the first fluid passage  212  and dressing  100 , similar to the suction adapter described in U.S. Pat. No. 8,801,685, which is incorporated by reference herein in its entirety. 
     In some embodiments, preferably, the fluid passage  212  is constructed from a compliant material that is flexible and that also permits fluid to pass through it if the spacer is kinked or folded over. Suitable materials for the fluid passage  212  include without limitation foams, including open-cell foams such as polyethylene or polyurethane foam, meshes, 3D knitted fabrics, non-woven materials, and fluid channels. In some embodiments, the fluid passage  212  may be constructed from materials similar to those described above in relation to the transmission layer  226 . Advantageously, such materials used in the fluid passage  212  not only permit greater patient comfort, but may also provide greater kink resistance, such that the fluid passage  212  is still able to transfer fluid from the wound toward the source of negative pressure while being kinked or bent. 
     In some embodiments, the fluid passage  212  may be comprised of a wicking fabric, for example a knitted or woven spacer fabric (such as a knitted polyester 3D fabric, Baltex 7970®, or Gehring 879®) or a nonwoven fabric. These materials selected are preferably suited to channeling wound exudate away from the wound and for transmitting negative pressure and/or vented air to the wound site, and may also confer a degree of kinking or occlusion resistance to the fluid passage  212 . In some embodiments, the wicking fabric may have a three-dimensional structure, which in some cases may aid in wicking fluid or transmitting negative pressure. In certain embodiments, including wicking fabrics, these materials remain open and capable of communicating negative pressure to a wound area under the typical pressures used in negative pressure therapy, for example between 40 to 150 mmHg. In some embodiments, the wicking fabric may include several layers of material stacked or layered over each other, which may in some cases be useful in preventing the fluid passage  212  from collapsing under the application of negative pressure. In certain embodiments, the wicking fabric used in the fluid passage  212  may be between 1.5 mm and 6 mm; more preferably, the wicking fabric may be between 3 mm and 6 mm thick, and may be comprised of either one or several individual layers of wicking fabric. In other embodiments, the fluid passage  212  may be between 1.2-3 mm thick, and preferably thicker than 1.5 mm Some embodiments, for example a suction adapter used with a dressing which retains liquid such as wound exudate, may employ hydrophobic layers in the fluid passage  212 , and only gases may travel through the fluid passage  212 . Additionally, and as described previously, the materials used in some embodiments of the system are preferably conformable and soft, which may help to avoid pressure ulcers and other complications which may result from a wound treatment system being pressed against the skin of a patient. 
     In some embodiments, preferably, the filter element  214  is impermeable to liquids, but permeable to gases, and is provided to act as a liquid barrier and to ensure that no liquids are able to escape from the wound dressing  100 . The filter element  214  may also function as a bacterial bather. Typically the pore size is 0.2 μm. Suitable materials for the filter material of the filter element  214  include 0.2 micron Gore™ expanded PTFE from the MMT range, PALL Versapore™ 200R, and Donaldson™ TX6628. Larger pore sizes can also be used but these may require a secondary filter layer to ensure full bioburden containment. As wound fluid contains lipids it is preferable in some embodiments, though not essential, to use an oleophobic filter membrane for example 1.0 micron MMT-332 prior to 0.2 micron MMT-323. This prevents the lipids from blocking the hydrophobic filter. The filter element can be attached or sealed to the port and/or the cover film over the orifice. For example, the filter element  214  may be molded into the fluidic connector  110 , or may be adhered to one or both of the top of the cover layer and bottom of the suction adapter  110  using an adhesive such as, but not limited to, a UV cured adhesive. 
     It will be understood that other types of material could be used for the filter element  214 . More generally a microporous membrane can be used which is a thin, flat sheet of polymeric material, this contains billions of microscopic pores. Depending upon the membrane chosen these pores can range in size from 0.01 to more than 10 micrometers. Microporous membranes are available in both hydrophilic (water filtering) and hydrophobic (water repellent) forms. In some embodiments, filter element  214  includes a support layer and an acrylic co-polymer membrane formed on the support layer. Preferably the wound dressing  100  according to certain embodiments uses microporous hydrophobic membranes (MHMs). Numerous polymers may be employed to form MHMs. For example, the MHMs may be formed from one or more of PTFE, polypropylene, PVDF and acrylic copolymer. All of these optional polymers can be treated in order to obtain specific surface characteristics that can be both hydrophobic and oleophobic. As such these will repel liquids with low surface tensions such as multi-vitamin infusions, lipids, surfactants, oils and organic solvents. 
     MHMs block liquids whilst allowing air to flow through the membranes. They are also highly efficient air filters eliminating potentially infectious aerosols and particles. A single piece of MHM is well known as an option to replace mechanical valves or vents. Incorporation of MHMs can thus reduce product assembly costs improving profits and costs/benefit ratio to a patient. 
     The filter element  214  may also include an odor absorbent material, for example activated charcoal, carbon fiber cloth or Vitec Carbotec-RT Q2003073 foam, or the like. For example, an odor absorbent material may form a layer of the filter element  214  or may be sandwiched between microporous hydrophobic membranes within the filter element. The filter element  214  thus enables gas to be exhausted through the orifice. Liquid, particulates and pathogens however are contained in the dressing. 
     Pump and Electronics on Dressing 
     In some embodiments, a pump and/or other electronic components can be configured to be positioned adjacent to or next to the absorbent and/or transmission layers so that the pump and/or other electronic components are still part of a single apparatus to be applied to a patient, but the pump and/or other electronics are positioned away from the wound site. In some embodiments, a pump and/or other electronic components can be positioned above or mounted above the absorbent and/or transmission layers described above.  FIG.  2 C  illustrates a wound dressing with the pump and/or other electronics positioned away from the wound site. The wound dressing can include an electronics area  1361  and an absorbent area  1360 . The absorbent area  1360  can include an absorbent material and can be positioned over the wound site. The electronics area  1361  can be positioned away from the wound site, such as by being located off to the side from the absorbent area  1360 . The electronics area  1361  can be positioned adjacent to and in fluid communication with the absorbent area  1360 . In some embodiments, each of the electronics area  1361  and absorbent area  1360  may be rectangular in shape, and positioned adjacent to one another. The electronics can be located in the electronics area  1361 , and the absorbent area  1360  can be placed on the wound. The dressing can include a wound contact layer  1310 , one or more spacer or transmission layers  1311  and/or  1317 , an absorbent layer  1322 , a moisture vapor permeable film or cover layer  1313  positioned above the contact layer, one or more spacer layers, absorbent layer, or other layers of the dressing. The wound contact layer  1310 , one or more spacer or transmission layers  1311  and/or  1317 , an absorbent layer  1322 , a moisture vapor permeable film or cover layer  1313  can include similar materials and characteristics as described with reference to the corresponding wound contact layer, spacer or transmission layer, absorbent layer, and cover layer described with reference to  FIGS.  2 A- 2 B . The wound dressing layers of the electronics area and the absorbent layer can be covered by one continuous cover layer  1313 . 
       FIG.  2 C  illustrates an embodiment of a wound dressing with the pump and electronic components offset from the absorbent area of the dressing positioned over the wound. The wound dressing can include a wound contact layer  1310  and a moisture vapor permeable film or cover layer  1313  that enclose an absorbent area  1360  and an electronics area  1361 . The cover layer  1313  can seal at the perimeter of the cover layer  1319  to the wound contact layer  1310  at the perimeter of the wound contact layer. The dressing can include an upper spacer layer or first spacer layer  1317  that includes a continuous layer of spacer material positioned below the cover layer  1313  and above the layers of the absorbent area and the layers of the electronics area. The continuous layer of spacer material or upper spacer layer  1317  can enable an air pathway between the two areas of the dressing. In some embodiments, the spacer layer  1317  is only provided over the absorbent area  1360  and does not extend over the electronics area  1361 . 
     The absorbent area  1360  of the dressing can include a second spacer layer  1311  or lower spacer layer and an absorbent layer  1322  positioned above the wound contact layer  1310 . The second spacer layer  1311  can allow for an open air path over the wound site. The absorbent layer  1322  can include a super absorber positioned in the absorbent area  1360  of the dressing. The absorbent layer  1322  can retain wound fluid within thereby preventing fluid passage of wound exudates into the electronics area  1361  of the dressing. The wound fluids can flow through the wound contact layer  1310 , to the lower spacer layer  1311 , and into the absorbent layer  1322 . The wound fluids are then spread throughout the absorbent layer  1322  and retained in the absorbent layer  1322  as shown by the directional arrows for wound fluids in  FIG.  2 C . 
     The electronics area  1361  of the dressing can include a plurality of layers of spacer material  1351  and electronic components  1350  embedded within the plurality of layers of spacer material  1351 . The layers of spacer material can have recesses or cut outs to embed the electronic components within whilst providing structure to prevent collapse. The electronic components  1350  can include a pump, power source, controller, and/or an electronics package. 
     In some embodiments, a partition, divider, and/or other separating material or device can be positioned between the absorbent area and the electronics area. In some embodiments, the separating material can be a partition  1362  as shown in  FIG.  2 C . In some embodiments, the partition  1362  can be positioned between the absorbent area  1360  and the electronics area  1361 . The partition  1362  can separate the absorbent layer  1322  and lower air flow spacer layer  1311  from the electronic housing segment of the dressing in the electronic area. The partition  1362  can prevent wound fluid from entering the electronic housing section of the dressing. In some embodiments, the partition can be a non-porous dam or other structure. The non-porous dam  1362  can include a cyanoacrylate adhesive bead or a strip of silicone. The air pathway through the dressing is shown in  FIG.  2 C  by directional arrows. The air flows through the wound contact layer  1310 , the lower spacer layer  1311 , and the absorbent layer  1322  and into the first spacer layer  1317 . The air can travel horizontally through the first spacer layer  1317  over and around the partition  1362  into the electronics area of the dressing. 
     A pump exhaust  1370  can be provided to exhaust air from the pump to the outside of the dressing. The pump exhaust can be in communication with the electronics area  1361  and the outside of the dressing. In some embodiments, the pump exhaust  1370  can be a flexible fluidic connector that includes a 3D material that allows for pressure to be applied without collapse of the exhaust port. Examples of an application where additional disclosure relating to the 3D material can be found include US Publication No. 2015/0141941, titled “Apparatuses and Methods for Negative Pressure Wound Therapy” published on May 21, 2015. The disclosure of this patent is hereby incorporated by reference in its entirety. 
     Application of Glue to Dressing 
     In certain embodiments, such as described above in  FIG.  2 B , fluid (for example, wound exudate) is handled by the dressing  100  by passing through the perforated wound contact layer  222 , into the transmission layer  226 , and is then absorbed and retained by the absorbent layer  221 . Fluid is then able to evaporate through the breathable backing layer  220 . However, in some embodiments, such as those observed during in vitro wound model testing, the absorbent layer fills up with the fluid in an unpredictable, and often, non-uniform manner Therefore, as described above, it may be desirable to prevent fluid from reaching certain areas of the absorbent layer. 
     In certain embodiments, fluid saturation of the absorbent layer may be impeded by applying a glue such as a cyanoacrylate Super Glue (for example Loctite, by Henkel) onto the backing layer. Herein this section and throughout the specification, the term “glue” will be used to indicate an adhesive such as Super Glue or any cyanoacrylate glue. Application of the glue affects the underlying absorbent layer by preventing fluid from being absorbed in the area below the glue. In some embodiments, the glue prevents certain areas of the absorbent material from swelling with fluid. Glue may be applied to the backing layer or elsewhere in the dressing via any suitable method, such as via an applicator tube. 
     Turning to  FIG.  3   , showing a top view of an embodiment of a wound dressing  300 , similar to the dressings described in  FIGS.  2 A- 2 B , a ring of glue  302  adheres the distal end  304  of the fluidic connector  306  to dressing  300 . Fluid was drawn into the dressing  308  and is visible through the backing layer  310  saturating the absorbent layer  312 . However, the fluid bends around the ring of glue  302 , even though the glue has been applied to the top of the backing layer  312 . In embodiments, application of glue to the top of the backing layer may beneficially prevent areas of the underlying absorbent layer  312  from becoming saturated and swelling. In embodiments, this prevention of saturation is beneficial as swelling of super absorber particles in this area can occlude the fluidic connection  306 , therefore preventing negative pressure delivery. 
     In certain embodiments, the glue may be located at a variety of locations on the backing layer. For example, the glue may be applied all the way to the edge of the opening in the backing layer and/or cover the entire distal end of the fluidic connector to the outer edge of the fluidic connector. As described above, the glue may be applied around the rim of the opening in the form of a ring. In embodiments, the glue may be applied as a single line or as a series of lines. The glue may be applied as a spiral or as concentric circles on the backing layer. In certain embodiments, the glue may be applied as distinct, single lines or multiple lines. The glue may be applied to the underside of the backing layer in any manner described in relation to the topside of the backing layer. 
     In embodiments, the glue may be applied around the periphery of the backing layer, for example, the entire periphery, 50% of the entirety, or 25% of the entirety. In certain embodiments the glue may be applied to only a portion of the perimeter of the distal end fluidic connector, for example 25%, 50%, or 75%. The glue may be applied to create channels in the underlying absorbent layers to channel wound exudate to the opening in the backing layer. In certain embodiments, the glue may be applied under the applicator portion of the fluidic connector, but not the fluid passage. In embodiments, the glue may be applied to only the outermost ring of the applicator portion of the fluidic connector. In certain embodiments, the glue may be applied to the sealing surface of the fluidic connector. In further embodiments, the glue may be applied on the backing layer around but not under the fluidic connector. 
     In certain embodiments, the glue may be applied directly to the absorbent layer in any manner described herein this section or elsewhere in the specification, particularly as described above in relation to the backing layer. In some embodiments, the glue may be applied directly to the transmission layer in any manner described herein this section or elsewhere in the specification, particularly as described above in relation to the backing layer. In embodiments, the glue may be applied directly to the wound contact layer in any manner described herein this section or elsewhere in the specification, particularly as described above in relation to the backing layer. 
       FIG.  4    shows two images of an embodiment of a wound dressing  400 , similar to the dressings of  FIGS.  2 A- 3   . Here, a thin bead of super glue was used to write “PICO” on the dressing  402 , specifically to the top of the backing layer. The dressing was then filled with a dye solution  404  which gradually revealed the word “PICO” written on the backing layer of the dressing. Similar to the glue ring shown in  FIG.  3   , application of glue to the top of the backing layer prevented areas of the underlying absorbent layer from becoming saturated. In certain embodiments, application of glue may be used to purposefully prevent areas of an absorbent layer (for example, around the distal end of the fluidic connector) from becoming saturated. 
       FIGS.  5 - 8    are images of embodiments of dressings similar to the dressings of  FIGS.  2 A- 4   . The dressings were sectioned using a clean pair of scissors and a single edge razor blade. These images were motivated by certain observations of in vitro wound dressings. After application of glue to the port of a PICO dressing, it was observed that in a wound model the glued area appeared to repel horse serum, which would normally track to the port and block the port, often before the dressing was full. For the above observation, the glue was applied between the port and the top film of the dressing and around the cut edges of a hole in the absorbent layer directly underneath the soft port. 
       FIG.  5    shows micro-CT images, at two cross-sectional angles, of embodiments of a dressing  500  similar to the dressings of  FIGS.  2 A- 4   . Here, glue applied over the backing layer of a dressing is compared side-by-side with a backing layer with no glue. Apart from the textured appearance of the top film on the glue areas there were no macro structural differences between the areas with and without glue, in that there is no distinct sign of the fibers being bound together. 
       FIG.  6    is a series of SEM images of an embodiment of a dressing similar to the dressings of  FIGS.  2 - 5   . Here, the backing layer was coated in glue  602 . Inspection of the dressing section coated with glue did show that under the backing layer (with the glue) there were a number of fibers  604  and a section of a super absorber particle (shown in  FIG.  7   ) which had been coated with granular particulates. The granular particulates were not observed on the flat cellulosic fibers. Chemical analysis would be required to determine if there is a thin film of glue on the flat fibers (i.e. fibers where granular particulates were not seen by SEM).  FIG.  6    further includes construction adhesive  606  which was identified based on previous knowledge of similar dressings. 
       FIG.  7    is a further series of SEM images of the wound dressing of  FIG.  6   . As in  FIG.  6   , glue has been applied to the backing layer of the dressing. Here, granular particulates  608  cover sections of super absorbent particles. 
       FIG.  8    is a series of SEM images of a wound dressing  700 , similar to the dressings of  FIGS.  6 - 7   , however here no superglue has been applied and no granular particulates are observed. 
     Dressing materials to control fluid flow 
     As discussed with reference to  FIG.  2 C  previously, a partition  1362  can be used between the absorbent area  1360  and the electronics area  1361  of a wound dressing containing the pump and electronics. The partition  1362  can separate the absorbent layer  1322  and lower air flow spacer layer  1311  from the electronic housing segment of the dressing in the electronic area. In some embodiments, materials can be incorporated into the dressing or to be used in place of or in addition to the partition  1362  to prevent wound fluid from entering the electronic housing section of the dressing. In some embodiments, the partition can be any material that completely or partially separates the absorbent area from the electronics area. In some embodiments, the dressing layers and/or electronic components can be coated with hydrophobic or hydrophilic coatings to provide the necessary separation of the absorbent area  1360  and electronics area  1361 . In some embodiments, the dressing layers and/or electronic components can be made of hydrophobic or hydrophilic materials. For example, as shown in  FIG.  2 C , the non-porous dam  1362  can include a cyanoacrylate adhesive bead or a strip of silicone. 
     In some embodiments, the absorbent area and electronics area can be separated by using an epoxy material or similar material. The epoxy material can be used in a manner similar to the use of the glue as described above with reference to  FIGS.  3 - 8   . For example, a silicone type adhesive can be used to direct fluid flow within the dressing in a similar manner to the use of the glue described above. The silicone adhesive can be a flexible adhesive that can seal to the area where it is applied. The silicone adhesive is hydrophobic which allows the fluid within the dressing to be diverted around or away from the silicone. In other embodiments, the hydrophobic or hydrophilic materials and coatings of the dressing and electronic components can be utilized to control and direct the flow of fluid within the dressing. 
     In some embodiments, the wound dressing with incorporated pump and electronics does not include a dam or structure separating the electronics and absorbent area. The wound dressing can instead utilize hydrophobic or hydrophilic properties of the materials to control fluid flow and protect the electronics from the fluid within the dressing. In some embodiments, the wound dressing can include a lower spacer layer  1311  that extends from the absorbent area to the electronics area or a separate spacer layer between the electronics area and wound contact layer. Therefore, a lower spacer layer could be positioned between the absorbent layer and wound contact layer in the absorbent area and between the electronics and the wound contact layer in the electronics area. The lower spacer layer can be formed of, treated with, or coated with a hydrophilic agent as described above that directs the fluid through the spacer layer, into the absorbent layer, and away from the electronics. 
     In some embodiments, a portion of the absorbent layer can be formed of, treated with, or coated with a hydrophobic material. For example, the absorbent layer located in or directly adjacent to the electronics area can be formed of, treated with, or coated with a hydrophobic material to direct fluid away from the pump and/or electronics and prevent fluid from pooling around the pump and/or electronics. The portion of the absorbent layer that does not include a hydrophobic material may act as described with reference to  FIGS.  2 A- 2 C  and prevent liquid collected in the wound dressing from flowing freely within the dressing. In some embodiments, the portion of the absorbent layer that does not include a hydrophobic material preferably acts so as to contain any liquid collected within that portion of the dressing. In some embodiments, all the dressing layers within the electronics area can be formed of, treated with, or coated with a hydrophilic material. 
     Features, materials, characteristics, or groups described in conjunction with a particular aspect, embodiment, or example are to be understood to be applicable to any other aspect, embodiment or example described herein unless incompatible therewith. All of the features disclosed in this specification (including any accompanying claims, abstract and drawings), and/or all of the steps of any method or process so disclosed, may be combined in any combination, except combinations where at least some of such features and/or steps are mutually exclusive. The protection is not restricted to the details of any foregoing embodiments. The protection extends to any novel one, or any novel combination, of the features disclosed in this specification (including any accompanying claims, abstract and drawings), or to any novel one, or any novel combination, of the steps of any method or process so disclosed. 
     While certain embodiments have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of protection. Indeed, the novel methods and systems described herein may be embodied in a variety of other forms. Furthermore, various omissions, substitutions and changes in the form of the methods and systems described herein may be made. Those skilled in the art will appreciate that in some embodiments, the actual steps taken in the processes illustrated and/or disclosed may differ from those shown in the figures. Depending on the embodiment, certain of the steps described above may be removed, others may be added. Furthermore, the features and attributes of the specific embodiments disclosed above may be combined in different ways to form additional embodiments, all of which fall within the scope of the present disclosure. 
     Although the present disclosure includes certain embodiments, examples and applications, it will be understood by those skilled in the art that the present disclosure extends beyond the specifically disclosed embodiments to other alternative embodiments and/or uses and obvious modifications and equivalents thereof, including embodiments which do not provide all of the features and advantages set forth herein. Accordingly, the scope of the present disclosure is not intended to be limited by the specific disclosures of certain embodiments herein, and may be defined by claims as presented herein or as presented in the future.