Patent Publication Number: US-11398295-B2

Title: System and method for classification of patients

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     The present application is a Continuation of U.S. application Ser. No. 14/549,069, filed Nov. 20, 2014, which is a Continuation of U.S. application Ser. No. 13/498,965, which is the U.S. National Stage of PCT/AU2010/001286, filed Sep. 30, 2010, which claims the benefit of U.S. Provisional Application No. 61/247,802, filed Oct. 1, 2009. 
    
    
     FIELD OF THE INVENTION 
     The present invention relates to classification of patients on the basis of expression of multiple biological markers. It is particularly suited to expression data from microarrays and other high-throughput platforms, although it will be appreciated that the invention may have wider applicability. 
     BACKGROUND TO THE INVENTION 
     It has long been recognised that diagnosis and treatment of disease on the basis of epidemiologic studies may not be ideal, especially when the disease is a complex one having multiple causative factors and many subtypes with possibly wildly varying outcomes for the patient. This has recently led to an increased emphasis on so-called “personalised medicine”, whereby specific characteristics of the individual are taken info account when providing care. 
     An important development in the move towards personalised care has been the ability to identify molecular markers which are associated with a particular disease state or which are predictive of the individual&#39;s response to a particular treatment. 
     For example, in relation to breast cancer, the estrogen receptor (ER) or HER2/neu (ErbB-2) status of a tumour can be used in determining a patient&#39;s suitability for therapies that target these molecules in the tumor cells. These molecular markers are examples of “companion diagnostics” which are used in conjunction with traditional tests such as histological status in order to guide treatment regimes. 
     In cancer cases where a tumour has metastasized, it is important to determine the tissue of origin of the tumour. The current diagnostic standard in such cases includes imaging, serum tests and immunohistochemistry (IHC) using one or more of a panel of known antibodies of different tumour specificity (Pavlidis et al, Eur J Cancer 39, p 1990 (2003); Burton et al, JAMA 280, p 1245 (1998); Varadhachary et al, Cancer 100, p 1776 (2004)). For approximately 3-5% of all cases, known as Cancer of Unknown Primary (CUP), these conventional approaches do not reach a definitive diagnosis, although some may eventually be solved with further, more extensive investigations (Horlings et al, J Clin Oncol 26, p 4435 (2008); Raab et al, Cancer 104, p 2205 (2005)). The range of tests able to be performed can depend not only on an individual patient&#39;s ability to tolerate potentially invasive, costly and time consuming diagnostic procedures, but also on the diagnostic tools at the clinician&#39;s disposal, which may vary between hospitals and countries. 
     To date, most diagnostic protocols are primarily reliant on microscopy, single gene or protein biomarkers (IHC) and imaging techniques such as MRI and PET Scan. Unfortunately, these techniques all have limitations and may not on their own provide adequate information to diagnose widely metastasized tumours, poorly differentiated malignancies, rare subtypes or unusual presentations of common cancers. 
     It has been hypothesized that the information gained from gene expression profiling can be used as a companion diagnostic to the above protocols, helping to confirm or refine the predicted primary origin in a focused and efficient manner. 
     Since the advent of various robotic and high throughput genomic technologies, including RT-PCR and microarray, several groups (van Laar et al, Int J Cancer 125, p 1390 (2009); Rosenfeld et al, Nature Biotechnology 26, p 462 (2008); Tothill et al, Cancer Res 65, p 4031 (2005); Bloom et al, Am J Pathol 164, p 9 (2004); Monzon et al, J Clin Oncol 27, p 2503 (2009); Ramaswamy et al, PNAS 98, 15149 (2001)) have investigated the use of gene expression data to predict the primary origin of a metastatic tumor. Prediction accuracies in the literature range from 78% to 89%. 
     A number of gene expression based, commercial diagnostic services have arisen since the sequencing of the human genome, offering a range of personalized diagnostic and prognostic assays. These services represent a significant advance in patient access to personalized medicine. However the requirement of shipping fresh or preserved human tissue to an interstate or international reference laboratory has the potential to expose sensitive biological molecules to adverse weather conditions and logistical delays. In some parts of the world it may also be prohibitively expensive to ship human tissue to a reference laboratory in a timely fashion, thus limiting access to this new technology. 
     Most current commercially available gene-expression based cancer tests use a proprietary “diagnostic” microarray or PCR-based assay (van Lear et al; Rosenfeld et al; Dumur et al, J Mol Diagn 10, p 67 (2008)). Such arrays allow assaying of a small set of genes chosen for a particular purpose and are custom manufactured for that purpose. Because of the limited set of genes that are quantified by these existing assays, the data generated generally cannot be used for multiple diagnostic or prognostic analyses if a different set of genes is required. Furthermore, whatever data is generated, it is generally not accessible to the clinician requesting the test should it be desired to conduct further investigations or compile a custom database of gene expression data for research purposes. 
     In view of the above deficiencies, it is desirable to provide a more flexible and efficient method and system for diagnosis and prognosis of a patient based on expression of multiple biological markers. 
     SUMMARY OF THE INVENTION 
     Accordingly, in a first aspect, the present invention provides a system for classifying a biological test sample, including: 
     a database populated with reference expression data, the reference expression data including expression levels of a plurality of molecules (polynucleotides or polypeptides) in a plurality of reference samples, the molecules including a set of marker molecules, each reference sample having a pre-assigned value for each of one or more clinically significant variables; 
     at least one processor; and 
     at feast one storage medium containing program instructions for execution by said processor, said program instructions causing said processor to execute the steps of: 
     accepting input expression data, the input expression data including a test vector of expression levels of the marker molecules in the biological test sample; and 
     passing the input expression data to one or more analysis programs, the analysis programs including at least one statistical classification program which has been trained to distinguish among said pre-assigned values on the basis of that part of the reference data corresponding to expression levels of the marker molecules; and 
     assigning one of said pre-assigned values to the test sample for at least one of said clinically significant variables using the statistical classification program. 
     By providing a reference data set with known clinical annotation in a single database in combination with the ability to accept input data from a user of the system, it is possible to have a centralised repository of disease classification which can be used to conduct different diagnostic or prognostic analyses (using different classification programs) with different sets of marker molecules. The system thus provides flexibility in that different tests may be conducted using the same reference data and input data without needing to re-assay the biological test sample. 
     Preferably, one of said analysis programs includes instructions for assessing the quality of the input expression data. The quality of the input expression data may be at least partly assessed according to the distribution across reference samples of one or more statistics derived from the reference data, the statistics including (for example) background intensity, percentage of molecules above detection threshold, ratio of 3′ expression level to 5′ expression level, slope of RNA degradation curve, normalisation factor, and log (base 10) ratio of mean intensity to mean background intensity. 
     Providing a quality control module as one of the analysis programs allows the clinician or other user to check that the data, as a whole, fall within acceptable ranges so that low-quality data are not passed to the classifier or classifiers. Use of low-quality data could lead to a diagnosis which inconsistent with other tests which may have been conducted, such as imaging or immunohistochemistry. 
     One of the classification programs may be a prediction of patient gender. This serves as a further quality check since, for example, if a female patient is predicted as male (on the basis of comparison to the reference data which are stratified according to gender), the fidelity of the data is cast into doubt. 
     In one embodiment, one of said analysis programs includes instructions for normalising the distribution of the input expression data to be comparable with the distribution of the reference expression data. This can help to increase the likelihood that differences between the input and reference data are due to real biological differences, and not due to mere statistical artifacts or to differences in the laboratory protocols used in generating the two data sets. 
     In a particularly preferred embodiment, each analysis program is executed on a different one of said processors. This can vastly improve the speed of the analysis. 
     In another aspect, the present invention provides a method for classifying a biological test sample, including the steps of: 
     choosing a set of marker molecules; 
     providing a database populated with reference expression data, the reference expression data including expression levels of a plurality of molecules in a plurality of reference samples, the plurality of molecules including at least the marker molecules, each reference sample having a pre-assigned value for each of one or more clinically significant variables; 
     accepting input expression data, the input expression data including a test vector of expression levels of the marker molecules in the biological test sample; and 
     assigning one of said pre-assigned values to the test sample for at least one of said clinically significant variables by passing the test vector to a statistical classification program; 
     wherein the statistical classification program has been trained to distinguish among said pre-assigned values on the basis of that part of the reference data corresponding to expression levels of the marker molecules. 
     The database may be in communication with a server computer which is interconnected to at least one client computer by a data network, said server computer being configured to accept the input expression data from the client computer. 
     Hosting the database on a server and allowing remote upload can improve the speed and efficiency of diagnosis. The clinician, having conducted a biopsy and assayed the sample (either themselves, or via a service laboratory located on site or nearby) to obtain a data file containing the expression levels of the marker molecules, can then simply upload the data file to the server for analysis and receive the test results within a short space of time, possibly within seconds. The server may reside on an internal network to which the clinician has access, or may be located on a wide area network, for example in the form of a Web server. The latter is particularly advantageous as it allows hosting and maintenance of a server accessing a large database of samples in one location, while a clinician located anywhere in the world and having access to relatively modest local resources can upload a data file to obtain a diagnosis based on a comprehensive set of annotated samples, such an analysis otherwise being inaccessible to the clinician. 
     The or each clinically significant variable may be selected from the group including disease state, disease prognosis, and treatment response. For example, the disease may be cancer, and the clinically significant variables may be organised according to a hierarchy, the levels of which may be selected from the group consisting of anatomical system, tissue type and tumour subtype. In that case, the classification program may include a multi-level classifier which classifies the test sample according to anatomical system, then tissue type, then tumour subtype. This provides a multi-marker, multi-level classification which is analogous to, but independent of, traditional approaches to diagnosis of tumour origin. 
     The marker molecules may include any combination of 100 or more of the polynucleotides listed in Table 4. We have found that sets of 100 or more of these molecules can provide a classification accuracy of greater than 85% for anatomical system and greater than 75% for tissue type. 
     In another embodiment, the disease is breast cancer, in which case the clinically significant variable may be risk of recurrence of the disease. The marker molecules in this embodiment may include the polynucleotides listed in Table 5. This is a prognostic, rather than diagnostic, application of the invention. 
     The invention is further applicable to other contexts in which predictive analysis is desired. For example, if a reference data set including expression levels for cancer patients having undergone one or more of various drug treatments is available, and the patients are annotated according to response to treatment, it would be possible to build and train a classifier to predict response of a patient who had not yet undergone the treatment, based on the expression levels of marker molecules in that patient. 
     In a particularly preferred embodiment, the reference expression data may be generated using a platform selected from the group including cDNA microarrays, oligonucleotide microarrays, protein microarrays, microRNA (miRNA) arrays, and high-throughput quantitative polymerase chain reaction (qPCR). 
     Oligonucleotide microarrays are particularly preferred for use in the present invention. If this type of microarray is used, each molecule being assayed is a polynucleotide, which may either be represented by a single probe on the microarray or by multiple probes, each probe having a different nucleotide sequence corresponding to part of the polynucleotide. If multiple probes are present, one of said analysis programs might include instructions for summarising the expression levels of the multiple probes into a single expression level for the polynucleotide. 
     Oligonucleotide microarrays such as those manufactured by Affymetrix, Inc and marketed under the trademark GeneChip currently represent the vast majority of microarrays in use for gene (and other nucleotide) expression studies. As such, they represent a standardised platform which particularly lends itself to collation of large databases of expression data, for example from cancer patients, in order to provide a basis for diagnostic or prognostic applications such as those provided by the present invention. 
     Preferably, the input expression data are generated using the same platform as the reference expression data. If the input expression data are generated using a different platform, then the identifier of the molecules in the input data are matched to the identifiers of the molecules in the reference data prior to performing classification, for example on the basis of sequence similarity, or by any other suitable means such as on the basis of GenBank accession number, Refseq or Unigene ID. 
     Preferably, the statistical classification program includes an algorithm selected from the group including k-nearest neighbours (kNN), linear discriminant analysis, principal components analysis, nearest centroid classification and support vector machines. 
     In a further aspect of the present invention, there is provided a method of classifying a biological test sample from a cancer patient, including the step of: comparing expression levels of a set of marker molecules in the test sample to expression levels of said set of marker molecules in a set of reference samples, each member of the set of reference samples having a known clinical annotation, to assign a clinical annotation to the test sample, 
     wherein the clinical annotation is selected from the group including anatomical system, tissue of origin, tumour subtype and risk of breast cancer recurrence. 
     In a yet further aspect, the present invention provides a system for classifying a biological test sample from a cancer patient, including: 
     a database populated with reference data, the reference data including expression levels of a set of marker molecules in a set of reference samples, each member of the set of reference samples having a known clinical annotation; 
     at least one processor; and 
     at least one storage medium containing program instructions for execution by said processor, said program instructions causing said processor to execute steps including: 
     accepting input data in the form of expression levels of the set of marker molecules in the test sample; and 
     assigning a clinical annotation to the test sample on the basis of the similarity of the input data to the expression levels of the set of marker molecules in the reference data; 
     wherein the clinical annotation is selected from the group including anatomical system, tissue of origin, tumour subtype and risk of breast cancer recurrence. 
     The marker molecules may include any combination of 100 or more of the polynucleotides listed in Table 4, or may include the polynucleotides listed in Table 5. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a schematic of a system according to one embodiment of the present invention; 
         FIG. 2  schematically shows the steps of an exemplary method in accordance with the invention; 
         FIG. 3  shows a schematic of another embodiment in which user requests are processed in parallel; 
         FIG. 4  illustrates selection of ranges for a quality control module for use with some embodiments of the present system and method; 
         FIG. 5  shows the position of samples belonging to a reference data set in multi-dimensional expression data space; 
         FIG. 6  summarises clinical annotations of reference samples in a reference data set used in one of the Examples; 
         FIGS. 7( a ) and 7( b )  show the classification accuracy for a multi-level classifier as used in one of the Examples; 
         FIGS. 8( a ) and 8( b )  show cross-validation results for a classification program used in another Example; and 
         FIGS. 9( a ) and 9( b )  show independent validation results for the classification program used in the Example of  FIGS. 8( a ) and 8( b ) . 
     
    
    
     DESCRIPTION OF PREFERRED EMBODIMENTS 
     In the following discussion, embodiments of the invention will be described mostly by reference to examples employing Affymetrix GeneChips. However, it will be understood by the skilled person that the methods and systems described herein may be readily adapted for use with other types of oligonucleotide microarray, or other measurement platforms. 
     The terms “gene”, “probe set” and “molecule” are used interchangeably for the purposed of the preferred embodiments described herein, but are not to be taken as limiting on the scope of the invention. 
     Referring to  FIGS. 1 and 2 , there is shown in schematic form a system  100  and method  200  for classifying a biological test sample. The sample is acquired  220  by a clinician and then treated  230  to extract, fluorescently label and hybridise RNA to microarray  115  according to standard protocols prescribed by the manufacturer of the microarray. Following hybridisation, the surface of the microarray is scanned at high resolution to detect fluorescence from regions of the surface corresponding to different RNA species. In the case of Affymetrix arrays, each scanned “feature” region contains hundreds of thousands of identical oligonucleotides (25 mers), which hybridise to any complementary fluorescently labelled molecules present in the test sample. The fluorescence intensity detected from each feature region is thus correlated with the abundance (expression level) of the complementary sequence in the test sample. 
     The scanning step results in the production of a raw data file (a CEL file), which contains the intensity values (and other information) for each probe (feature region) on the array. Each probe is one of the 25 mers described above and forms part of one of a multiplicity of “probe sets”. Each probe set contains multiple probes, usually 11 or more for a gene expression microarray. A probe set usually represents a gene or part of a gene. Occasionally, a gene will be represented by more than one probe set. 
     Once the CEL file is obtained, the user may upload it (step  120  or  240 ) to server  110 . 
     Accepting Input Data 
     In the preferred embodiments, the system is implemented using a network including at least one server computer  110 , for example a Web server, and at least one client computer. Software running on the Web server can be used to accept the input data file (CEL file) containing the multiple molecule abundance measurements (probe signals) for a particular patient from the client computer over a network connection. This information is stored in the system user&#39;s dedicated directory on a file server, with upload filenames, date/time and other details stored in a relational database  112  to allow for later retrieval. 
     The Web server  110  subsequently allows the user to select individual CEL files for analysis by a list of available diagnostic and prognostic methods, the list being able to be configured to add new methods as they are implemented. Results from the specific analysis requested, in the format of text, numbers and images, are also stored in the relational database  112  and delivered to the user via the Web server  110 . All data generated by a particular user is linked to a unique identifier and can be retrieved by the user by logging into to the Web server  110  using a username and password combination. 
     When an analysis is requested by the user, at step  122 , the raw data from the CEL file are passed to a processor, which executes a program  130   a  contained on a storage medium, which is in communication with the processor. 
     Accepting Clinical Data Input 
     In conjunction with the file that contains the multiple molecule abundance measurements (probe signals) for a particular patient, the user can also be asked to input other information about the patient. This information can be used for predictive, prognostic, diagnostic or other data analytical purposes, independently or in association with the molecular data. These variables can include patient age, gender, tumor grade, estrogen receptor status, Her-2 status, or other clinicopathological assessments. An electronic form can be used to collect this information, which the user can submit to a secure relational database. 
     Algorithms that combine ‘traditional’ clinical variables or patient demographic data and molecular data can result in more statistically significant results than algorithms that use only one or the other. The ability to collect and analyse all three types of data is a particularly advantageous aspect of at least some embodiments of the invention. 
     Low Level Analysis 
     Program  130   a  is a low-level analysis module, which carries out steps of background correction, normalisation and probe set summarisation (grouped as step  250  in  FIG. 2 ). 
     Background adjustment is desirable because the probe signals (fluorescence intensities) include signal from non-biological sources, such as optical and electronic noise, and non-specific binding to sequences which are not exactly complementary to the sequence of the probe. A number of background adjustment methods are known in the art. For example, Affymetrix arrays Contain so-called ‘MM’ (mismatch) probes which are located adjacent to ‘PM’ (perfect match) probes on the array. The sequence of the MM probe is identical to that of the PM probe, except for the 13 th  base in its sequence, and accordingly the MM probes are designed to measure non-specific binding, A number of known methods use functions of PM-MM or log 2 (PM)-log 2 (MM) to derive a background-adjusted probe signal, for example the ideal Mismatch (IM) method used by the Affymetrix MAS 5.0 software (Affymetrix, “Statistical Algorithms Description Document” (2002), Santa Clara, Calif., incorporated herein in its entirety by reference). Other methods ignore MM, for example the model-based adjustment of Irizarry et al (Biostatistics 4, p 249 (2003)), or use sequence-based models of non-specific binding to calculate an adjusted probe signal (Wu et al, JASA 99, p 909 (2004)). 
     Normalisation is generally required in order to remove systematic biases across arrays due to non-biological variation. Methods known in the art include scaling normalisation, in which the mean or median log probe signal is calculated for a set of arrays, and the probe signals on each array adjusted so that they all have the same mean or median; housekeeping gene normalisation, in which the probe or probe set signals for a standard set of genes (known to vary little in the biological system of interest) in the test sample are compared to the probe signals of that same set of genes in the reference samples, and adjusted accordingly; and quantile normalisation, in which the probe signals are adjusted so that they have the same empirical distribution in the test sample as in the reference samples (Bolstad et al, Bioinformatics 19, p 185 (2003)). 
     If the arrays contain multiple probes per probe set, then these can be summarised by program  130   a  in any one of a number of ways to obtain a probe set expression level, for example by calculating the Tukey biweight of the log (PM-IM) values for the probes in each probe set (Affymetrix, “Statistical Algorithms Description Document” (2002)). 
     Quality Control 
     Once the low-level analysis is completed, the background-corrected, normalised and, if necessary, summarised, data are passed (step  124 ) to program  130   b , which is a quality control (QC) module. The execution of program  130   b  is depicted as step  260  in  FIG. 2 . 
     Quality data from an individual array can be used to infer the reliability and reproducibility of the entire molecular/genomic profile. One way to do this is to establish ranges for each quality metric that correspond to acceptable, warning and unacceptable levels. By analysing a large number of genomic profiles from reference samples comprising disparate tissue types and laboratory locations, a large body of quality data can be accumulated and stored in database  112 . 
     The data for each of the quality metrics used herein approximately follow a log-normal distribution, as illustrated schematically in  FIG. 4 . Acceptable, warning and unacceptable ranges for each metric are thus calculated by determining the 25 th  percentile (Q1, indicated by 410), 75 th  percentile (Q3, indicated by 430) and corresponding interquartile range (IQR, indicated by 420) of the log-transformed values. Acceptable values are defined as those which lie between Q1-1.5*IQR and Q3+1.5*IQR. 
     Values in the ranges 405, 435 corresponding to ranges (Q1-1.5*IQR) to (Q1-3.0*IQR) or (Q3+1.5*IQR) to (Q3+3.0*IQR) are referred to as outliers, and are given a warning label. Values which lie to the left 403 or right 437, respectively, of those ranges are referred to as “far outliers” and are deemed to be unacceptably outside of the range of values used to develop and validate the gene expression test for which the test sample is being submitted. 
     The median, Q1/Q3 and IQR rather than mean and standard deviation are used to determine thresholds as the former are robust to outliers. This prevents the ranges from being overly influenced by a small number of samples that may not be representative of the true general distribution. 
     Table 1 is an example output from program  130   b  which describes each quality measurement (QC1 to QC8) and shows the value determined from the specific array being investigated. It also identifies the acceptable range and a variable classifier (Ok/Warning/Reject) column, which may change colour based on the contents of each cell. This allows the end user to rapidly determine if their input data is suitable for further analysis. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 example QC output 
               
            
           
           
               
               
               
               
            
               
                 Assessment 
                 Example Result 
                 Acceptable range 
                 Within range? 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 QC1. Percentage of total gene set detected 
                 41.50 
                 28% to 62% 
                 OK 
               
               
                 QC2. Background intensity (Average, Log 10) 
                 2.7 
                 1.2 to 2.2 
                 REJECT 
               
               
                 QC3. Normalization factor (MAS5, log 10) 
                 −0.06 
                 −0.99 to 1.3    
                 OK 
               
               
                 QC4. Ratio of GAPDH 3′:5′ probes 
                 1.01 
                 0.9 to 1.5 
                 OK 
               
               
                 QC5. Ratio of B-actin 3′:5′ probes 
                 1.7 
                 0.7 to 1.6 
                 WARNING 
               
               
                 QC6. RNA degradation analysis 
                 1.98 
                 −0.4 to 8.3   
                 OK 
               
               
                 QC7. Housekeeping genes normalization factor 
                 −0.45 
                 −1.1 to 0.9   
                 OK 
               
               
                 QC8. Signal to noise ratio (log 10) 
                 1.66 
                 1.0 to 2.1 
                 OK 
               
               
                   
               
            
           
         
       
     
     Predictive Analysis 
     If a test sample passes the QC checks of program  130   b  it can then proceed (step  270 ) to predictive analysis as carried out by statistical classification program  135 , which is used to assign a value of a clinically relevant variable to the sample, Such clinical parameters could include: 
     The primary tissue of origin for a biopsy of metastatic cancer; 
     The molecular similarity to patients who do or do not experience disease relapse with a defined time period after their initial treatment; 
     The molecular similarity to patients who respond poor or well to a particular type of therapeutic agent; 
     The status of clinicopathological markers used in disease diagnosis and patient management, including ER, PR, Her2, angiogenesis markers (VEGF, Notch), Ki67 etc.; 
     Possible chromosomal aberrations, including deletions and amplifications of part or whole of a chromosome; 
     The molecular similarity to patients who respond poor or well to a particular type of radiotherapy; 
     Other methods that may be developed by 3 party developers and implemented in the system via an Application Programming interface (API). 
     The predictive algorithms used in at least some embodiments of the present invention function by comparing the data from the test sample, to the series of reference samples for which the variable of interest is confidently known, usually having been determined by other more traditional means. The series of known reference samples can be used as individual entities, or grouped in some way to reduce noise and simplify the classification process. 
     Algorithms such as the K-nearest neighbor (KNN) algorithm use each reference sample of known type as separate entities. The selected genes/molecules (probe sets) are used to project the known samples into multi-dimensional gene/molecule space as shown in  FIG. 5 , in which the first three principal components for each sample are plotted. The number of dimensions is equal to the number of genes. The test sample is then inserted into this space and the nearest K reference samples are determined, using one of a range of distance metrics, for example the Euclidean or Mahalanobis distance between the points in the multi-dimensional space. Evaluating the classes of the nearest K reference samples to the test sample and determining the weighted or non-weighted majority class present can then be used to infer the class of the test sample. 
     The variation of classes present in the K nearest neighbors can also be used as a confidence score. For example, if 4 out of 5 of the nearest neighbor samples to a given test sample were of the same class (eg Ovarian cancer) the predicted class of the test sample would be Ovarian cancer, with a confidence score of 4/5=80%. 
     Other methods of prediction rely on creating a template or summarized version of the data generated from the reference samples of known class. One way this can be done is by taking the average of each selected gene across clinically distinct groups of samples (for example, those individuals treated with a particular drug who experience a positive response compared to those with the same disease/treatment who experience a negative or no response). Once this template has been determined, the class of a test sample can be inferred by calculating a similarity score to one or both templates. The similarity score can be a correlation coefficient. 
     Classifiers such as the nearest centroid classifier (NCC), linear discriminant analysis (LDA) or support vector machines operate on this basis (SVM). LDA and SW carry out weighting of the genes/molecules when creating the classification template, which can reduce the impact of outlier measurements and spread the classification workload evenly over all genes/molecules selected, rather than relying on a subset to contribute to a majority of the total index score calculated. This can be the case when using a simple correlation coefficient as a predictive index. 
     Preparation of Reference Data Set 
     To make clinically useful predictions about a specimen of biological material that has been collected from an individual patient, a large database of reference data from patients with the same condition is desirable. The reference samples are preferably processed using similar, more preferably identical, laboratory processes and the reference data are ideally generated using the same type of measurement platform, for example, an oligonucleotide microarray, to avoid the need to match gene identifiers across different platforms. 
     The reference data can be generated from tissue specifically collected or obtained for the diagnostic test being created, or from publically available sources, such as the NCBI. Gene Expression Omnibus (GEO: http://wvvw.ncbi.nlm.nih.gov/geo/). Clinical details about each patient can be used to determine whether the finished database accurately reflects the targeted patient population, for example with regard to age/sex/ethnicity and other relevant parameters specific to the disease of interest. 
     Conical annotations can be used for analysis of the same input data at different levels. For example, cancer can be classified using a hierarchy of annotations. These begin at the system level, and then progress to unique tissues and subtypes, which are defined on the basis of pathological or molecular characteristics. The NCI Thesaurus is a source of hierarchical cancer classification information (http://nciterms.nci.nih.gov/NCIBrowser/Dictionary.do). 
     All data generated or obtained can be stored in organized flat files or in relational database format, such as Microsoft Access or Microsoft SQL Server. In this format it can be readily accessed and processed by analytical algorithms trained to use all or part of the data to predict the status of a clinically relevant parameter for a given test sample. 
     Presentation of Results to User 
     Following execution of classification program  135 , the clinical predictions are stored in relational database  112 . An interface  111  from the server  110  to database  112  can be used to deliver online and offline results to the end user. Online results can be delivered in HTML or other dynamic file format, whereas portable document format (PDF) can be used for creating permanent files that can be downloaded from the interface  111  and stored indefinitely. Result information in the form of text, HTML or PDF can also be delivered to the user by electronic mail. 
     AJAX Web 2.0 technologies can be used to streamline the presentation of online results and general functionality of the Web site. 
     Parallel Processing of Data 
     A single processor may be used to execute each of the programs  130   a ,  130   b ,  135  and any other analysis desired. However, it is advantageous to configure the system  100  such that each analysis module is managed by a separate processor. This allows parallel execution of different user requests to be performed simultaneously, with the results stored in a single centralized relational database  112  and structured file system. 
     In this embodiment, illustrated schematically in  FIG. 3 , each module is programmed to monitor  320  a specific network directory (“trigger directory”). When the system operator requests  305  an analysis, either by uploading a new data file or requesting an additional analysis on a previously uploaded data file, the Web server  110  creates a “trigger file” in the directory  325  being monitored by the processing application. This trigger file contains the operator&#39;s unique identifier and the unique name of the data file on which to carry out the analysis. 
     When the classification module  135  detects (step  330 ) one or more trigger files, the contents of the file are read and stored temporarily in memory. The processing application then performs its preconfigured analysis routine, using the data file corresponding to the information contained in the trigger file. The data file is retrieved from the user&#39;s data directory (residing on a storage medium in communication with the server or other network-accessible computer) and read into memory in order to perform the requested calculations and other functions. Once the analysis routine is complete, the trigger file is deleted and the module  135  returns to monitoring its trigger directory for the next trigger file. 
     Multiple versions of the same classification module  135  can run simultaneously on different processors, all configured to monitor the same trigger directory and write or save their output to the same relational database  112  and file storage system. Alternatively, different modules in addition to classification module  135  could be run on different processors at the same time using the same input data. For processes that take several minutes (eg initial chip processing and Quality Module  130   a ) this enables analysis requests  305  that are submitted, while an existing request is underway, to be commenced before the completion of the first. 
     Addition of Further Analysis Modules 
     It will be appreciated that many other types of analysis (diagnostic, predictive, prognostic or other) may be conducted within the framework of the system provided by the present invention. When a new analysis program is created, it can be added to the list of analysis modules selectable by a user for execution on one or more input data files. 
     Additional modules can be added to the system by creating additional ‘trigger’ directories, monitored by analysis scripts. These can, of course, be used in conjunction with existing modules, such as the quality module described above. 
     A molecular profile can be adapted for use with the system by providing 
     Details of the technology used to measure the status of the molecules necessary to perform the test (e.g. genes, proteins, antibodies); 
     A list of molecular identifiers (probe or probe set identifiers, or gene or protein databank accession numbers, for example) specific to the platform used to develop, and to be Used for future application of, the test; 
     A reference set of data from patients with the target disease (or other clinical identification) derived from the same class of patients; and 
     A statistical equation which describes how data corresponding to the molecular identifiers and reference dataset are used to predict the status of a test sample. 
     A custom results interface can then be created and incorporated into the system, linked to the underlying databases and results delivery mechanisms described previously, Technology-specific quality control measurements can also be incorporated, if they are not adequately represented by those contained in the quality module described previously. 
     Example 1 
     Preparation of Reference Data 
     The expO data, NCBI GEO accession number GSE2109, generated by the International Genomics Consortium, was used as a reference data set to train a tumor origin classifier. 
     Downloaded CEL files corresponding to the reference samples were pre-processed with the algorithms from Affymetrix MAS 5.0 software and compiled into BRB ArrayTools format, with housekeeping gene normalization applied. Using the associated clinical information from GSE2109, samples were classified at 3 levels of clinical annotation; (1) anatomical system (n=13), (2) tissue (n=29) and (3) subtype (n=295), as shown in  FIG. 6 . For Level 1 and 2 annotations, a minimum class size of three was set. The mean class sizes for the three levels of sample annotation were: (1) 149; (2) 66 and (3) 6, correlating with number of neighbors used in the kNN algorithm (r 2 =0.99). 
     Data Analysis and Web Service Construction 
     Predictive gene expression models were developed using BRB ArrayTools and translated to automated scripts in the R statistical language, incorporating functions from the Bioconductor project (Gentleman et al, Genome Biology 5, R80 (2004)). The Web service was constructed in the Microsoft ASP.net language (Redmond, USA; version 3.5) with supporting relational databases developed in Microsoft SQL Server 2008. Statistical analysis of internal cross validation and independent validation series results was performed using Minitab (Minitab Inc. State College Pa., version 15.1.3) and MedCalc (MedCalc Software, Mariakerke, Belgium). 
     Selecting a Reference Array for Housekeeping Gene Based Normalization 
     Most cells in the human body express under most circumstances, at comparatively constant levels, a set of genes referred to as “housekeeping genes” for their role in maintaining structural integrity and core cellular processes such as energy metabolism. The Affymetrix U133 Plus 2.0 GeneChip (NCBI GEO accession number GPL 570) contains 100 probe sets that correspond to known housekeeping genes, which can be used for data normalization and quality control purposes. For normalization purposes, the 100 housekeeping genes present on a given array within the reference data set were compared to those of a specific normalization array. To select a normalization array for this test. BRB-ArrayTools was used to identify the “median” array from the entire reference data set. The algorithm used was as follows: 
     Let N be the number of arrays, and let i be an index of arrays running from 1 to N. 
     For each array i, compute the median log-intensity of the array (denoted M i . 
     Select a median M from the [M 1 , . . . , M N ] values. If N is even, then the median M is the lower of the two middle values. 
     Choose as the median array the one for which the median log-intensity M i  equals the overall median M. 
     Housekeeping gene normalization was applied to each array in the reference data set. The differences between the log 2  expression levels for housekeeping genes in the array and log 2  expression levels for housekeeping genes in the normalization array were computed. The median of these differences was then subtracted from the log 2  expression levels of all 54,000 probe sets, resulting in a normalized whole genome gene expression profile. 
     Selection of Marker Probe Sets for Tumor-Type Discrimination 
     To select probe sets for the prediction of tumor origin, ‘one-v-all’ comparisons (t-tests) were performed for each tissue type in the training set (n=29) to identify probe sets which were differentially expressed in each tissue type compared to the rest of the data set. The probe sets identified by this procedure provide a characteristic gene expression signature for tumours originating in each tissue type. 
     In each comparison, genes that had a p-value less than 0.01 for differential expression, and a minimum fold change of 1.5 in either direction (upregulated or downregulated) were identified as marker probe sets. The analysis was performed using BRB ArrayTools (National Institute of Health, US). The 29 sets of marker probe sets were combined into a single list of 2221 unique probe sets, which are listed in Table 4. 
     The normalized expression data corresponding to these marker probe sets was retrieved from the complete 1942 reference sample×54000 probe set reference data, and this subset was passed to a kNN algorithm at both Level 1 (Anatomical-system, 5NN (nearest neighbours) used) and Level 2 (Tissue, 3NN used) clinical annotation. 
     To evaluate whether a smaller set of probe sets would achieve lower misclassification rates, leave-one-out cross validation (LOOCV) of the level 1 and 2 classifiers was performed using multiples of 100 probe sets from 10 to 2220, after ranking in descending order of variance. For each cross-validation test, the percentage agreement between the true and predicted classes was recorded and this is shown in  FIGS. 7( a ) and 7( b ) . The maximum classification accuracy obtained was 90% for Level 1 and 82% for Level 2. Reducing the number of marker probe sets used did not significantly improve computation speed. 
     Validation Datasets for Prediction of Tumor Origin 
     CEL files from 22 independent Affymetrix datasets (all Affymetrix U133 Plus 2.0) containing a total of 1,710 reference samples were downloaded from NCBI GEO and processed as previously described. These datasets represent a broad range of primary and metastatic cancer types, contributing institutes and geographic locations, as detailed in Table 2. 
     Of 1,461 primary tumor validation samples that passed all QC checks, the Level 1 and Level 2 classifiers predicted 92% and 82% correctly. Tumor Subtype data were not available for most validation datasets; therefore percentage accuracy of this level (3) of the classifier was not calculated. The difference observed between Level 1 and Level 2 classifier accuracy is largely influenced by ovary/endometriod and colon/gastric misclassifications. As with all comparisons of novel diagnostic methods with clinically derived results, the percentage agreement is dependent on multiple factors, including the accuracy of the clinical annotation, integrity of the sample annotations and data files as well as the performance characteristics of the method itself. 
     General linear model analysis was performed on the proportion of correct level 1 and level 2 predictions, including tissue type (n=10) and geographic location (n=3) in a regression equation to determine if these variables were factors in overall result accuracy. For Level 1 predictions (anatomical system), no significant difference in result accuracy was observed for tissue type (P=0.13) or geographic location (P=0.86). For Level 2 predictions (tissue type), a marginally significant difference was observed with tissue type (P=0.049) but no significant difference associated with location (P=0.38). The significant difference associated with tissue type at Level 2 is most likely associated with the small sample size of some tumor types. 
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Independent primary tumor datasets used for validation of the tumor origin classifier. 
               
               
                 Percent agreement with the original (clinically-determined) diagnosis shown. Agreement of the Level 
               
               
                 2 classifier increases to 90% if colon/rectum misclassifications are considered as correct. 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 Level 1 
                 Level 2 
               
               
                   
                   
                   
                   
                   
                 classifier % 
                 classifier % 
               
               
                   
                   
                 NCBI 
                   
                   
                 agreement 
                 agreement 
               
               
                   
                   
                 GEO 
                   
                 % samples 
                 with 
                 with 
               
               
                 Cancer 
                   
                 Dataset 
                   
                 passing all QC 
                 clinical 
                 clinical 
               
               
                 Type 
                 Origin 
                 ID 
                 samples 
                 checks 
                 diagnosis 
                 diagnosis 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Breast 
                 Boston, MA, USA 
                 GSE5460 
                 125 
                 95% 
                 100% 
                 99% 
               
               
                 Breast 
                 San Diego, CA, 
                 GSE7307 
                 5 
                 100% 
                 100% 
                 100% 
               
               
                   
                 USA 
               
               
                 Colon 
                 Singapore 
                 GSE4107 
                 22 
                 91% 
                 100% 
                 90% 
               
               
                 Colon 
                 Zurich, Switerland 
                 GSE8671 
                 64 
                 100% 
                 100% 
                 69% 
               
               
                 Gastric 
                 Singapore 
                 GSE15460 
                 236 
                 96% 
                 89% 
                 44% 
               
               
                 Gastric 
                 Singapore 
                 GSE15459 
                 200 
                 95% 
                 96% 
                 54% 
               
               
                 Liver 
                 Taipel, Taiwan 
                 GSE6222 
                 13 
                 85% 
                 91% 
                 91% 
               
               
                 Liver 
                 Cambridge, MA, 
                 GSE9829 
                 91 
                 82% 
                 99% 
                 99% 
               
               
                   
                 USA 
               
               
                 Lung 
                 St Louis, MO, USA 
                 GSE12667 
                 75 
                 99% 
                 89% 
                 88% 
               
               
                 Lung 
                 Villejuif, France 
                 GSE10445 
                 72 
                 57% 
                 93% 
                 95% 
               
               
                 Melanoma 
                 Tampa, FL, USA 
                 GSE7553 
                 40 
                 100% 
                 68% 
                 65% 
               
               
                 Melanoma 
                 Durham, NC, USA 
                 GSE10282 
                 43 
                 100% 
                 65% 
                 84% 
               
               
                 Ovarian 
                 Melbourne, 
                 GSE9891 
                 285 
                 100% 
                 99% 
                 96% 
               
               
                   
                 Australia 
               
               
                 Ovarian 
                 Ontario, Canada 
                 GSE10971 
                 37 
                 97% 
                 100% 
                 72% 
               
               
                 Prostate 
                 Ann Arbor, MI, 
                 GSE3325 
                 19 
                 95% 
                 89% 
                 89% 
               
               
                   
                 USA 
               
               
                 Prostate 
                 San Diego, CA, 
                 GSE7307 
                 10 
                 100% 
                 90% 
                 90% 
               
               
                   
                 USA 
               
               
                 Soft 
                 Paris, France 
                 M-EXP- 
                 16 
                 100% 
                 75% 
                 75% 
               
               
                 tissue 
                   
                 964* 
               
               
                 Soft 
                 New York, NY, 
                 GSE12195 
                 83 
                 99% 
                 98% 
                 98% 
               
               
                 tissue 
                 USA 
               
               
                 Thyroid 
                 columbus, OH, 
                 GSE6004 
                 18 
                 67% 
                 100% 
                 100% 
               
               
                   
                 USA 
               
               
                 Thyroid 
                 Valhalla, NY, USA 
                 GSE3678 
                 14 
                 93% 
                 92% 
                 100% 
               
               
                   
                   
                   
                 Total: 
                 Mean: 92% 
                 Mean: 
                 Mean: 
               
               
                   
                   
                   
                 1468 
                   
                 92% 
                 85% 
               
               
                   
               
               
                 *Dataset obtained from EBI ArrayExpress (http://www.ebi.ac.uk/microarray-as/ae/) 
               
            
           
         
       
     
     Creating an Automated Microarray Quality Control System 
     The total set of 2,775 U133 Plus 2.0 arrays used in the training and validation stages of this analysis was used to derive acceptable ranges, as discussed above, for 8 different QC parameters. The ranges are shown in Table 3. 
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Quality module components and acceptable ranges, determined 
               
               
                 by analysis of all training and validation samples. 
               
               
                 Lower range = Q1 − 3*IQR, Upper range = Q3 + 3*IQR 
               
            
           
           
               
               
               
            
               
                   
                   
                 Acceptable 
               
               
                 Number 
                 Quality assessment 
                 range 
               
               
                   
               
               
                 1 
                 Percentage of total gene set detected 
                 28% to 62% 
               
               
                 2 
                 Background intensity (Average across chip, 
                 1.2 to 2.2 
               
               
                   
                 Log 10) 
               
               
                 3 
                 Normalization factor (MAS5, log10) 
                 −0.99 to 1.3    
               
               
                 4 
                 Ratio of GAPDH 3′:5′ probes 
                 0.9 to 1.5 
               
               
                 5 
                 Ratio of B-actin 3′:5′ probes 
                 0.7 to 1.6 
               
               
                 6 
                 RNA degradation analysis (slope of regression 
                 −0.4 to 8.3   
               
               
                   
                 line) 
               
               
                 7 
                 Housekeeping genes normalization factor 
                 −1.1 to 0.9   
               
               
                 8 
                 Signal to noise ratio (log10) - mean probe 
                 1.0 to 2.1 
               
               
                   
                 intensity/mean background intensity 
               
               
                   
               
            
           
         
       
     
     The Bioconductor package ‘SimpleAffy’ (Wilson and Miller, Bioinformatics 21, p 3683 (2005)) was used to generate measurements of background intensity, percentage of probe sets detected and 3′/5′ ratios. RNA degradation slopes were computed using the ‘AffyRNAdeg’ function in the ‘affy’ package (Gautier et al, Bioinformatics 20, p 307 (2004)). 
     The quality module also includes two assessments of data normalization. These are the MASS scaling factor and the log (base 2) of the housekeeping gene set normalization factor (i.e. the median difference between the log expression levels of housekeeping genes in a given sample and those of the housekeeping genes in the reference data as a whole). 
     The final assessment that is made is the signal-to-noise ratio (SNR) which is the log 10 ratio of mean probe set intensity divided by the mean background intensity. This metric is designed to ensure there is a sufficiently large difference between probe and background hybridization, which will not occur if the RNA is heavily degraded or problems with procedures such as RNA labelling or chip washing have occurred. 
     Patient Render Prediction 
     As an additional data quality control measure, a predictive Diagonal Linear Discriminant Analysis (DLDA) algorithm can be used for gender classification. Genes that were differentially expressed with a p-value less than 0.001 and minimum fold change of 2 between the 1,453 female and 695 male patients (regardless of cancer type) were selected as those which could distinguish males from females. A test sample, which is submitted for the purpose of other classification analyses, can be passed to the DLDA algorithm, which predicts the gender of the test sample based on the expression levels of the gender-discriminating genes thus identified. 
     The trained DLDA classifier for patient gender consists of 183 probe sets. During 3×3 fold cross validation, the gender of 97% of the 2,148 samples was correctly predicted, with a sensitivity of 97% and specificity of 95% from this internal validation exercise. 
     A Three-Stage Classifier for Prediction of Tumor Origin 
     Reflecting the nature of existing diagnostic workflows for metastatic tumors, a novel 3-tiered approach to predicting the origin of a metastatic tumor biopsy was developed. For each test sample analysed, 3 rounds of kNN classification were performed, using the 3 levels of annotation previously described, i.e. (1) anatomical system, (2) tissue and (3) histological subtype, with k=5, 3 and 1 respectively. The decreasing value of k with increasing specificity of tissue annotation was chosen based on the decreasing mean class size at each tier of the classifier, with which it is highly correlated (r 2 =0.99). 
     A measurement of classifier confidence was generated for Level 1 (k=5) and Level 2 (k=3) results by determining the relative proportion of test sample&#39;s 5 or 3 neighbors (respectively) that contribute to the winning class. The Level 3 prediction (k=1) identifies the specific individual tumor from the reference database that is closest to the test sample, in multi-dimensional gene expression space. As such, it is not possible to calculate a weighted confidence score for this level of classifier. 
     To determine the internal cross validation performance of the reference data and 3-tier algorithm, leave-one-out cross validation (LOOCV) was performed on the reference data set, using annotation levels 1 and 2. Results were tamed and overall percentage agreement and class-specific sensitivities and specificities were determined. The R/Bioconductor package “class” was used for kNN classification and predictive analyses. 
     Example 2 
     Two training data sets from untreated breast cancer patients (GEO accession numbers GSE4922 and GSE6352), including a total of 425 samples hybridized to Affymetrix HG-U133A arrays (GEO accession number GPL96) were downloaded in CEL file format. Clinical data were available for age, grade, ER status, tumour size, lymph node involvement, and follow-up data for up to 15 years after diagnosis were also available. An independent validation data set, consisting of samples from 128 Tamoxifen-treated patients hybridized to Affymetrix HG-U133Plus2 arrays with age, grade, ER status, nodal involvement and tumour size data, was also obtained. 
     A semi-supervised method substantially in line with the method described by Bair and Tibshirani (PLoS Biology 2, p 511 (2004), incorporated herein in its entirety by reference) was used, with algorithm settings of k=2 (number of principal components for the “supergenes”), p-value threshold of 0.001 for significance of a probe set being univariately correlated with survival, 10-fold cross-validation, and age, grade, nodes, tumour size and ER status used as clinical covariates. The method identified 200 prognostic marker probe sets, shown in Table 5, and gave the following model for risk of recurrence (Formula 1): 
     
       
         
           
             PI 
             = 
             
               
                 
                   ∑ 
                   
                     i 
                     = 
                     l 
                   
                   200 
                 
                 ⁢ 
                 
                   
                     w 
                     i 
                   
                   ⁢ 
                   
                     x 
                     i 
                   
                 
               
               - 
               
                 0.139601 
                 ⁢ 
                 
                   ( 
                   grade 
                   ) 
                 
               
               + 
               
                 0.64644 
                 ⁢ 
                 
                   ( 
                   ER 
                   ) 
                 
               
               + 
               
                 0.938702 
                 ⁢ 
                 
                   ( 
                   nodes 
                   ) 
                 
               
               + 
               
                 0.010679 
                 ⁢ 
                 
                   ( 
                   
                     size 
                     ⁡ 
                     
                       ( 
                       mm 
                       ) 
                     
                   
                   ) 
                 
               
               + 
               
                 0.023595 
                 ⁢ 
                 
                   ( 
                   age 
                   ) 
                 
               
               + 
               0.243639 
             
           
         
       
     
     In Formula 1, w i  is the weight of the i th  probe set, x i  is its log expression level, and PI is prognostic index. 
       FIGS. 8( a ) and 8( b )  show Kaplan Meier analysis of 10-fold cross validation predictions made for the 425-sample training set. Log rank tests were used to compare the survival characteristics of the two risk groups identified. 
     Evaluation of the cross-validation predictions made for the training set revealed a highly statistically significant difference in the survival characteristics of the high and low risk groups. Of the 425 patients, 297 (70%) were classified as high-risk and 128 (30%) as high risk. The p-value of the Kaplan Meier analysis log-rank test was P&lt;0,0001 and the hazard ratio of the classifier was 3.75 (95% confidence interval 2.47 to 5.71). 
     In the training set, 85% of patients classified as low risk were disease-recurrence free at 5 years after treatment. In the high-risk group, 41% of patients experienced disease recurrence within this same time period. 
       FIGS. 9( a ) and 9( b )  show survival characteristics of the high and low risk groups for the independent validation data set. The groups identified in this cohort are, more similar to each other up to 3 years after diagnosis. This is likely attributable to the use of Tamoxifen in these patients. After this time point survival characteristics are significantly different. 
     Kaplan Meier analysis and log-rank testing was performed on the independent validation set. The P-value associated with the log rank test was P=0.0007. A hazard ratio of 4.90 (95% confidence interval 1.96 to 12.28) was observed. These figures indicate that the classifier was able to stratify the patients into two groups with markedly different survival characteristics. 
     Overall those individuals in the high-risk group are 4.9 times more likely to experience disease recurrence than those in the low risk group in the 10 years after diagnosis. Three quarters of the independent validation patients are classified as low risk (n=97) and of these, 90% are recurrence-free after 5 years. 
     Additionally, multivariate Cox Proportional Hazards analysis was performed on the 128 sample independent validation set. Two models were built and tested, one including the clinical variables only, and the other including the clinical variables and classifier prediction variable (high/low risk). The significance level of the clinical-only model was P=0.0291, whilst for the clinical+classifier model it was P=0.0126, The classifier remained independently prognostic in the second model (P=0.048). 
     These results indicate that the classifier (comprised of 200 genes+5 clinical variables) is able to stratify patients into high and low risk groups for disease recurrence. Furthermore, the stratification of patients is more statistically significant than the use of clinical variables alone. The prognostic significance of the classifier has been evaluated in patients who do and do not receive Tamoxifen treatment following their initial diagnosis and surgical procedure. 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 List of probes used for tumor origin prediction 
               
            
           
           
               
               
               
               
            
               
                 Affymetrix Probe ID 
                 Genbank Accession number 
                 Unigene ID 
                 Gene symbol 
               
               
                   
               
               
                 204769_s_at 
                 M74447 
                 Hs.502 
                 TAP2 
               
               
                 206422_at 
                 NM_002054 
                 Hs.516494 
                 GCG 
               
               
                 209937_at 
                 BC001386 
                 Hs.133527 
                 TM4SF4 
               
               
                 204673_at 
                 NM_002457 
                 Hs.315 
                 MUC2 
               
               
                 1554436_a_at 
                 AY126671 
                 Hs.660883 
                 REG4 
               
               
                 214303_x_at 
                 AW192795 
                 Hs.534332 
                 MUC5AC 
               
               
                 204697_s_at 
                 NM_001275 
                 Hs.150793 
                 CHGA 
               
               
                 223447_at 
                 AY007243 
                 Hs.660883 
                 REG4 
               
               
                 242601_at 
                 AA600175 
                 Hs.443169 
                 HEPACAM2 
               
               
                 215688_at 
                 AL359931 
                 Hs.591111 
                 RASGRF1 
               
               
                 208131_s_at 
                 NM_000961 
                 Hs.302085 
                 PTGIS 
               
               
                 205249_at 
                 NM_000399 
                 Hs.1395 
                 EGR2 
               
               
                 206750_at 
                 NM_002360 
                 Hs.520612 
                 MAFK 
               
               
                 210170_at 
                 BC001017 
                 Hs.85862 
                 PDLIM3 
               
               
                 203240_at 
                 NM_003890 
                 Hs.111732 
                 FCGBP 
               
               
                 207214_at 
                 NM_014471 
                 Hs.555934 
                 SPINK4 
               
               
                 214385_s_at 
                 AI521646 
                 Hs.534332 
                 MUC5AC 
               
               
                 216206_x_at 
                 BC005365 
                 Hs.531754 
                 MAP2K7 
               
               
                 228335_at 
                 AW264204 
                 Hs.31595 
                 CLDN11 
               
               
                 227971_at 
                 AI653107 
                 Hs.209527 
                 NRK 
               
               
                 207591_s_at 
                 NM_006015 
                 Hs.468972 
                 ARID1A 
               
               
                 239144_at 
                 AA835648 
                 Hs.713609 
                 B3GAT2 
               
               
                 203806_s_at 
                 NM_000135 
                 Hs.567267 
                 FANCA 
               
               
                 232546_at 
                 AL136528 
                 Hs.697294 
                 TP73 
               
               
                 201262_s_at 
                 NM_001711 
                 Hs.821 
                 BGN 
               
               
                 206690_at 
                 NM_001094 
                 Hs.368417 
                 ACCN1 
               
               
                 201431_s_at 
                 NM_001387 
                 Hs.519659 
                 DPYSL3 
               
               
                 233985_x_at 
                 AV706485 
                 Hs.21816 
                 PPP1R9A 
               
               
                 210240_s_at 
                 U20498 
                 Hs.435051 
                 CDKN2D 
               
               
                 229529_at 
                 AI827830 
                 Hs.78061 
                 TCF21 
               
               
                 231542_at 
                 AL157421 
               
               
                 226755_at 
                 AI375939 
                 Hs.510543 
                 LOC642587 
               
               
                 223597_at 
                 AB036706 
                 Hs.50813 
                 ITLN1 
               
               
                 204337_at 
                 AL514445 
                 Hs.386726 
                 RGS4 
               
               
                 236017_at 
                 AI199453 
                 Hs.105818 
                 CDKL3 
               
               
                 205822_s_at 
                 NM_002130 
                 Hs.397729 
                 HMGCS1 
               
               
                 216339_s_at 
                 AF086641 
                   
                 TNXA 
               
               
                 228658_at 
                 R54042 
                 Hs.653712 
                 MIAT 
               
               
                 228399_at 
                 AI569974 
                 Hs.123933 
                 OSR1 
               
               
                 208323_s_at 
                 NM_004306 
                 Hs.181107 
                 ANXA13 
               
               
                 1560770_at 
                 BQ719658 
                 Hs.387804 
                 PABPC1 
               
               
                 202928_s_at 
                 NM_024165 
                 Hs.166204 
                 PHF1 
               
               
                 204359_at 
                 NM_013231 
                 Hs.533710 
                 FLRT2 
               
               
                 220037_s_at 
                 NM_016164 
                 Hs.655332 
                 LYVE1 
               
               
                 201666_at 
                 NM_003254 
                 Hs.522632 
                 TIMP1 
               
               
                 205161_s_at 
                 NM_003847 
                 Hs.31034 
                 PEX11A 
               
               
                 211062_s_at 
                 BC006393 
                 Hs.78068 
                 CPZ 
               
               
                 203929_s_at 
                 AI056359 
                 Hs.101174 
                 MAPT 
               
               
                 238878_at 
                 AA496211 
                 Hs.300304 
                 ARX 
               
               
                 229335_at 
                 BE645821 
                 Hs.370984 
                 CADM4 
               
               
                 229212_at 
                 BE220341 
                 Hs.644056 
                 CSNK2A1 
               
               
                 219059_s_at 
                 AL574194 
                 Hs.655332 
                 LYVE1 
               
               
                 1559064_at 
                 BC035502 
                 Hs.601591 
                 NUP153 
               
               
                 228004_at 
                 AL121722 
                   
                 C20orf56 
               
               
                 230242_at 
                 AA634220 
                 Hs.13349 
                 NFASC 
               
               
                 206115_at 
                 NM_004430 
                 Hs.534313 
                 EGR3 
               
               
                 238231_at 
                 AV700263 
                 Hs.233458 
                 NFYC 
               
               
                 236131_at 
                 AW452631 
               
               
                 207935_s_at 
                 NM_002274 
                 Hs.654550 
                 KRT13 
               
               
                 214079_at 
                 AK000345 
                 Hs.272499 
                 DHRS2 
               
               
                 241987_x_at 
                 BF029081 
                 Hs.567758 
                 SNX31 
               
               
                 206463_s_at 
                 NM_005794 
                 Hs.272499 
                 DHRS2 
               
               
                 220779_at 
                 NM_016233 
                 Hs.149195 
                 PADI3 
               
               
                 214624_at 
                 AA548647 
                 Hs.159309 
                 UPK1A 
               
               
                 203074_at 
                 NM_001630 
                 Hs.705389 
                 ANXA8L2 
               
               
                 205319_at 
                 NM_005672 
                 Hs.652235 
                 PSCA 
               
               
                 202226_s_at 
                 NM_016823 
                 Hs.638121 
                 CRK 
               
               
                 210655_s_at 
                 AF041336 
                 Hs.220950 
                 FOXO3 
               
               
                 1552627_a_at 
                 NM_001173 
                 Hs.592313 
                 ARHGAP5 
               
               
                 1556168_s_at 
                 BC042133 
                 Hs.361778 
                 LOC339766 
               
               
                 210143_at 
                 AF196478 
                 Hs.188401 
                 ANXA10 
               
               
                 208750_s_at 
                 AA580004 
                 Hs.286221 
                 ARF1 
               
               
                 204268_at 
                 NM_005978 
                 Hs.516484 
                 S100A2 
               
               
                 207782_s_at 
                 NM_007319 
                 Hs.3260 
                 PSEN1 
               
               
                 209863_s_at 
                 AF091627 
                 Hs.137569 
                 TP63 
               
               
                 220773_s_at 
                 NM_020806 
                 Hs.208765 
                 GPHN 
               
               
                 202825_at 
                 NM_001151 
                 Hs.246506 
                 SLC25A4 
               
               
                 242733_at 
                 AI457588 
               
               
                 39248_at 
                 N74607 
                 Hs.234642 
                 AQP3 
               
               
                 214908_s_at 
                 AC004893 
                 Hs.203952 
                 TRRAP 
               
               
                 210337_s_at 
                 U18197 
                 Hs.387567 
                 ACLY 
               
               
                 200693_at 
                 NM_006826 
                 Hs.74405 
                 YWHAQ 
               
               
                 203953_s_at 
                 BE791251 
                 Hs.647023 
                 CLDN3 
               
               
                 232481_s_at 
                 AL137517 
                 Hs.525105 
                 SLITRK6 
               
               
                 206658_at 
                 NM_030570 
                 Hs.488861 
                 UPK3B 
               
               
                 214487_s_at 
                 NM_002886 
                 Hs.98643 
                 RAP2B 
               
               
                 242509_at 
                 R71072 
               
               
                 230188_at 
                 AW138350 
                 Hs.4285 
                 ICHTHYIN 
               
               
                 213992_at 
                 AI889941 
                 Hs.145586 
                 COL4A6 
               
               
                 232176_at 
                 R70320 
                 Hs.525105 
                 SLITRK6 
               
               
                 202927_at 
                 NM_006221 
                 Hs.465849 
                 PIN1 
               
               
                 229151_at 
                 BE673587 
                 Hs.101307 
                 SLC14A1 
               
               
                 1555814_a_at 
                 AF498970 
                 Hs.247077 
                 RHOA 
               
               
                 206209_s_at 
                 NM_000717 
                 Hs.89485 
                 CA4 
               
               
                 231904_at 
                 AU122448 
                 Hs.365116 
                 U2AF1 
               
               
                 211797_s_at 
                 U62296 
                 Hs.233458 
                 NFYC 
               
               
                 208852_s_at 
                 AI761759 
                 Hs.699155 
                 CANX 
               
               
                 219936_s_at 
                 NM_023915 
                 Hs.591292 
                 GPR87 
               
               
                 235976_at 
                 AI680986 
                 Hs.525105 
                 SLITRK6 
               
               
                 213050_at 
                 AA594937 
                 Hs.99141 
                 COBL 
               
               
                 206504_at 
                 NM_000782 
                 Hs.89663 
                 CYP24A1 
               
               
                 217294_s_at 
                 U88968 
                 Hs.517145 
                 ENO1 
               
               
                 1564494_s_at 
                 AK075503 
                 Hs.464336 
                 P4HB 
               
               
                 209772_s_at 
                 X69397 
                 Hs.644105 
                 CD24 
               
               
                 236926_at 
                 AW074836 
                 Hs.173984 
                 TBX1 
               
               
                 208621_s_at 
                 BF663141 
                 Hs.487027 
                 EZR 
               
               
                 206771_at 
                 NM_006953 
                 Hs.632787 
                 UPK3A 
               
               
                 202820_at 
                 NM_001621 
                 Hs.171189 
                 AHR 
               
               
                 200059_s_at 
                 BC001360 
                 Hs.247077 
                 RHOA 
               
               
                 1558214_s_at 
                 BG330076 
                 Hs.534797 
                 CTNNA1 
               
               
                 218284_at 
                 NM_015400 
                 Hs.618504 
                 SMAD3 
               
               
                 207686_s_at 
                 NM_001228 
                 Hs.599762 
                 CASP8 
               
               
                 201461_s_at 
                 NM_004759 
                 Hs.643566 
                 MAPKAPK2 
               
               
                 200624_s_at 
                 AA577695 
                 Hs.268939 
                 MATR3 
               
               
                 219909_at 
                 NM_024302 
                 Hs.380710 
                 MMP28 
               
               
                 207612_at 
                 NM_003393 
                 Hs.421281 
                 WNT8B 
               
               
                 205856_at 
                 NM_015865 
                 Hs.101307 
                 SLC14A1 
               
               
                 211934_x_at 
                 W87689 
                 Hs.595071 
                 GANAB 
               
               
                 204379_s_at 
                 NM_000142 
                 Hs.1420 
                 FGFR3 
               
               
                 202527_s_at 
                 NM_005359 
                 Hs.75862 
                 SMAD4 
               
               
                 208853_s_at 
                 L18887 
                 Hs.699155 
                 CANX 
               
               
                 232116_at 
                 AL137763 
                 Hs.657920 
                 GRHL3 
               
               
                 212236_x_at 
                 Z19574 
                 Hs.2785 
                 KRT17 
               
               
                 201017_at 
                 BG149698 
                 Hs.522590 
                 EIF1AX 
               
               
                 206393_at 
                 NM_003282 
                 Hs.523403 
                 TNNI2 
               
               
                 210065_s_at 
                 AB002155 
                 Hs.271580 
                 UPK1B 
               
               
                 209192_x_at 
                 BC000166 
                 Hs.528299 
                 KAT5 
               
               
                 202354_s_at 
                 AW190445 
                 Hs.68257 
                 GTF2F1 
               
               
                 235417_at 
                 BF689253 
                 Hs.62604 
                 SPOCD1 
               
               
                 211151_x_at 
                 AF185611 
                 Hs.655229 
                 GH1 
               
               
                 AFFX-HSAC07/X00351_5_at 
                 AFFX-HSAC07/X00351_5 
                 Hs.520640 
                 ACTB 
               
               
                 204602_at 
                 NM_012242 
                 Hs.40499 
                 DKK1 
               
               
                 220026_at 
                 NM_012128 
                 Hs.567422 
                 CLCA4 
               
               
                 210756_s_at 
                 AF308601 
                 Hs.487360 
                 NOTCH2 
               
               
                 205132_at 
                 NM_005159 
                 Hs.709351 
                 ACTC1 
               
               
                 213022_s_at 
                 NM_07124 
                 Hs.133135 
                 UTRN 
               
               
                 206207_at 
                 NM_001828 
                 Hs.889 
                 CLC 
               
               
                 210064_s_at 
                 NM_006952 
                 Hs.271580 
                 UPK1B 
               
               
                 1558093_s_at 
                 BI832461 
                 Hs.268939 
                 MATR3 
               
               
                 213002_at 
                 AA770596 
                 Hs.519909 
                 MARCKS 
               
               
                 217234_s_at 
                 AF199015 
                 Hs.487027 
                 EZR 
               
               
                 225211_at 
                 AW139723 
                 Hs.334846 
                 PVRL1 
               
               
                 223687_s_at 
                 AA723810 
                 Hs.69517 
                 LY6K 
               
               
                 1556793_a_at 
                 AK091138 
                 Hs.592149 
                 FAM83C 
               
               
                 1552496_a_at 
                 NM_015198 
                 Hs.99141 
                 COBL 
               
               
                 205157_s_at 
                 NM_000422 
                 Hs.2785 
                 KRT17 
               
               
                 204247_s_at 
                 NM_004935 
                 Hs.647078 
                 CDK5 
               
               
                 201401_s_at 
                 M80776 
                 Hs.83636 
                 ADRBK1 
               
               
                 200664_s_at 
                 BG537255 
                 Hs.515210 
                 DNAJB1 
               
               
                 209364_at 
                 U66879 
                 Hs.370254 
                 BAD 
               
               
                 202449_s_at 
                 NM_002957 
                 Hs.590886 
                 RXRA 
               
               
                 214639_s_at 
                 S79910 
                 Hs.67397 
                 HOXA1 
               
               
                 AFFX-HUMISGF3A/M97935_5_at 
                 AFFX-HUMISGF3A/M97935_5 
                 Hs.642990 
                 STAT1 
               
               
                 227143_s_at 
                 AA706658 
                 Hs.591054 
                 BID 
               
               
                 215050_x_at 
                 BG325734 
                 Hs.643566 
                 MAPKAPK2 
               
               
                 215037_s_at 
                 U72398 
                 Hs.516966 
                 BCL2L1 
               
               
                 209051_s_at 
                 AF295773 
                 Hs.106185 
                 RALGDS 
               
               
                 206466_at 
                 AB014531 
                 Hs.655760 
                 ACSBG1 
               
               
                 203582_s_at 
                 NM_004578 
                 Hs.296169 
                 RAB4A 
               
               
                 205523_at 
                 U43328 
                 Hs.2799 
                 HAPLN1 
               
               
                 201131_s_at 
                 NM_004360 
                 Hs.461086 
                 CDH1 
               
               
                 222008_at 
                 NM_001851 
                 Hs.590892 
                 COL9A1 
               
               
                 205524_s_at 
                 NM_001884 
                 Hs.2799 
                 HAPLN1 
               
               
                 217744_s_at 
                 NM_022121 
                 Hs.520421 
                 PERP 
               
               
                 226213_at 
                 AV681807 
                 Hs.118681 
                 ERBB3 
               
               
                 209902_at 
                 U49844 
                 Hs.271791 
                 ATR 
               
               
                 201727_s_at 
                 NM_001419 
                 Hs.184492 
                 ELAVL1 
               
               
                 213909_at 
                 AU147799 
                 Hs.288467 
                 LRRC15 
               
               
                 213487_at 
                 AI762811 
                 Hs.465627 
                 MAP2K2 
               
               
                 231175_at 
                 N48613 
                 Hs.582993 
                 C6orf65 
               
               
                 206869_at 
                 NM_001267 
                 Hs.97220 
                 CHAD 
               
               
                 209771_x_at 
                 AA761181 
               
               
                 1557053_s_at 
                 BC035653 
                 Hs.529420 
                 UBE2G2 
               
               
                 208867_s_at 
                 AF119911 
                 Hs.529862 
                 CSNK1A1 
               
               
                 221215_s_at 
                 NM_020639 
                 Hs.517310 
                 RIPK4 
               
               
                 203889_at 
                 NM_003020 
                 Hs.156540 
                 SCG5 
               
               
                 227803_at 
                 AA609053 
                 Hs.35198 
                 ENPP5 
               
               
                 216379_x_at 
                 AK000168 
               
               
                 202454_s_at 
                 NM_001982 
                 Hs.118681 
                 ERBB3 
               
               
                 206075_s_at 
                 NM_001895 
                 Hs.644056 
                 CSNK2A1 
               
               
                 205066_s_at 
                 NM_006208 
                 Hs.527295 
                 ENPP1 
               
               
                 232523_at 
                 AU144892 
                 Hs.438709 
                 MEGF10 
               
               
                 231736_x_at 
                 NM_020300 
                 Hs.389700 
                 MGST1 
               
               
                 208651_x_at 
                 M58664 
                 Hs.644105 
                 CD24 
               
               
                 229271_x_at 
                 BG028597 
                 Hs.523446 
                 COL11A1 
               
               
                 201596_x_at 
                 NM_000224 
                 Hs.406013 
                 KRT18 
               
               
                 225275_at 
                 AA053711 
                 Hs.482730 
                 EDIL3 
               
               
                 201235_s_at 
                 BG339064 
                 Hs.519162 
                 BTG2 
               
               
                 231867_at 
                 AB032953 
                 Hs.654631 
                 ODZ2 
               
               
                 222392_x_at 
                 AJ251830 
                 Hs.520421 
                 PERP 
               
               
                 217888_s_at 
                 NM_018209 
                 Hs.25584 
                 ARFGAP1 
               
               
                 204037_at 
                 BF055366 
                 Hs.126667 
                 LPAR1 
               
               
                 206298_at 
                 NM_021226 
                 Hs.655672 
                 ARHGAP22 
               
               
                 160020_at 
                 Z48481 
                 Hs.2399 
                 MMP14 
               
               
                 213870_at 
                 AL031228 
                 Hs.390171 
                 COL11A2 
               
               
                 212089_at 
                 M13452 
                 Hs.594444 
                 LMNA 
               
               
                 221900_at 
                 AI806793 
                 Hs.353001 
                 COL8A2 
               
               
                 224918_x_at 
                 AI220117 
                 Hs.389700 
                 MGST1 
               
               
                 204320_at 
                 NM_001854 
                 Hs.523446 
                 COL11A1 
               
               
                 218186_at 
                 NM_020387 
                 Hs.632469 
                 RAB25 
               
               
                 204736_s_at 
                 NM_001897 
                 Hs.513044 
                 CSPG4 
               
               
                 213276_at 
                 T15766 
                 Hs.351887 
                 CAMK2B 
               
               
                 202677_at 
                 NM_002890 
                 Hs.664080 
                 RASA1 
               
               
                 204724_s_at 
                 NM_001853 
                 Hs.126248 
                 COL9A3 
               
               
                 205959_at 
                 NM_002427 
                 Hs.2936 
                 MMP13 
               
               
                 208992_s_at 
                 BC000627 
                 Hs.463059 
                 STAT3 
               
               
                 266_s_at 
                 L33930 
                 Hs.644105 
                 CD24 
               
               
                 208650_s_at 
                 BG327863 
                 Hs.644105 
                 CD24 
               
               
                 229088_at 
                 BF591996 
                 Hs.527295 
                 ENPP1 
               
               
                 213943_at 
                 X99268 
                 Hs.66744 
                 TWIST1 
               
               
                 209008_x_at 
                 U76549 
                 Hs.533782 
                 KRT8 
               
               
                 214247_s_at 
                 AU148057 
                 Hs.292156 
                 DKK3 
               
               
                 210827_s_at 
                 U73844 
                 Hs.67928 
                 ELF3 
               
               
                 225147_at 
                 AL521959 
                 Hs.487479 
                 CYTH3 
               
               
                 214726_x_at 
                 AL556041 
                 Hs.183706 
                 ADD1 
               
               
                 205475_at 
                 NM_007281 
                 Hs.7122 
                 SCRG1 
               
               
                 1565269_s_at 
                 AF047022 
                 Hs.648565 
                 ATF1 
               
               
                 1565162_s_at 
                 D16947 
                 Hs.389700 
                 MGST1 
               
               
                 217901_at 
                 BF031829 
                 Hs.412597 
                 DSG2 
               
               
                 37892_at 
                 J04177 
                 Hs.523446 
                 COL11A1 
               
               
                 204854_at 
                 NM_014262 
                 Hs.631655 
                 LEPREL2 
               
               
                 211300_s_at 
                 K03199 
                 Hs.654481 
                 TP53 
               
               
                 201839_s_at 
                 NM_002354 
                 Hs.542050 
                 TACSTD1 
               
               
                 213791_at 
                 NM_006211 
                 Hs.339831 
                 PENK 
               
               
                 224650_at 
                 AL117612 
                 Hs.201083 
                 MAL2 
               
               
                 211597_s_at 
                 AB059408 
                 Hs.654864 
                 HOPX 
               
               
                 228834_at 
                 BF240286 
                 Hs.709952 
                 TOB1 
               
               
                 206655_s_at 
                 NM_000407 
                 Hs.283743 
                 GP1BB 
               
               
                 206237_s_at 
                 NM_013957 
                 Hs.453951 
                 NRG1 
               
               
                 203352_at 
                 NM_002552 
                 Hs.558364 
                 ORC4L 
               
               
                 223319_at 
                 AF272663 
                 Hs.208765 
                 GPHN 
               
               
                 238516_at 
                 BF247383 
                 Hs.471119 
                 BMPR2 
               
               
                 205980_s_at 
                 NM_015366 
                 Hs.102336 
                 PRR5 
               
               
                 219183_s_at 
                 NM_013385 
                 Hs.170944 
                 CYTH4 
               
               
                 202790_at 
                 NM_001307 
                 Hs.513915 
                 CLDN7 
               
               
                 229296_at 
                 AI659477 
                 Hs.711775 
                 LOC100128501 
               
               
                 207384_at 
                 NM_005091 
                 Hs.137583 
                 PGLYRP1 
               
               
                 201792_at 
                 NM_001129 
                 Hs.439463 
                 AEBP1 
               
               
                 224506_s_at 
                 BC006362 
                 Hs.134292 
                 PPAPDC3 
               
               
                 203954_x_at 
                 NM_001306 
                 Hs.647023 
                 CLDN3 
               
               
                 220273_at 
                 NM_014443 
                 Hs.156979 
                 IL17B 
               
               
                 231941_s_at 
                 AB037780 
                 Hs.599259 
                 MUC20 
               
               
                 226210_s_at 
                 AI291123 
                 Hs.525589 
                 MEG3 
               
               
                 216326_s_at 
                 AF059650 
                 Hs.519632 
                 HDAC3 
               
               
                 229218_at 
                 AA628535 
                 Hs.489142 
                 COL1A2 
               
               
                 236028_at 
                 BE466675 
                 Hs.518726 
                 IBSP 
               
               
                 227510_x_at 
                 AL037917 
                 Hs.642877 
                 MALAT1 
               
               
                 203351_s_at 
                 AF047598 
                 Hs.558364 
                 ORC4L 
               
               
                 208643_s_at 
                 J04977 
                 Hs.388739 
                 XRCC5 
               
               
                 206201_s_at 
                 NM_005924 
                 Hs.170355 
                 MEOX2 
               
               
                 203325_s_at 
                 AI130969 
                 Hs.210283 
                 COL5A1 
               
               
                 209466_x_at 
                 M57399 
                 Hs.371249 
                 PTN 
               
               
                 202997_s_at 
                 BE251211 
                 Hs.626637 
                 LOXL2 
               
               
                 223199_at 
                 AA404592 
                 Hs.515032 
                 MKNK2 
               
               
                 214917_at 
                 AK024252 
                 Hs.43322 
                 PRKAA1 
               
               
                 205257_s_at 
                 NM_001635 
                 Hs.592182 
                 AMPH 
               
               
                 223749_at 
                 AF329836 
                 Hs.110062 
                 C1QTNF2 
               
               
                 209604_s_at 
                 BC003070 
                 Hs.524134 
                 GATA3 
               
               
                 209603_at 
                 AI796169 
                 Hs.524134 
                 GATA3 
               
               
                 209602_s_at 
                 AI796169 
                 Hs.524134 
                 GATA3 
               
               
                 244579_at 
                 AI086336 
               
               
                 210239_at 
                 U90304 
                 Hs.435730 
                 IRX5 
               
               
                 223864_at 
                 AF269087 
                 Hs.373787 
                 ANKRD30A 
               
               
                 206509_at 
                 NM_002652 
                 Hs.99949 
                 PIP 
               
               
                 206378_at 
                 NM_002411 
                 Hs.46452 
                 SCGB2A2 
               
               
                 237339_at 
                 AI668620 
                 Hs.144151 
                 hCG_25653 
               
               
                 227629_at 
                 AA843963 
                 Hs.368587 
                 PRLR 
               
               
                 209343_at 
                 BC002449 
                 Hs.516769 
                 EFHD1 
               
               
                 1553602_at 
                 NM_058173 
                 Hs.348419 
                 MUCL1 
               
               
                 217014_s_at 
                 AC004522 
                 Hs.546239 
                 AZGP1 
               
               
                 209309_at 
                 D90427 
                 Hs.546239 
                 AZGP1 
               
               
                 214451_at 
                 NM_003221 
                 Hs.33102 
                 TFAP2B 
               
               
                 1559949_at 
                 T56980 
               
               
                 237395_at 
                 AV700083 
                 Hs.176588 
                 CYP4Z1 
               
               
                 205913_at 
                 NM_002666 
                 Hs.103253 
                 PLIN 
               
               
                 202575_at 
                 NM_001878 
                 Hs.405662 
                 CRABP2 
               
               
                 1553434_at 
                 NM_173534 
                 Hs.591431 
                 CYP4Z2P 
               
               
                 204653_at 
                 BF343007 
                 Hs.519880 
                 TFAP2A 
               
               
                 206227_at 
                 NM_003613 
                 Hs.442180 
                 CILP 
               
               
                 1553394_a_at 
                 NM_003221 
                 Hs.33102 
                 TFAP2B 
               
               
                 228462_at 
                 AI928035 
                 Hs.282089 
                 IRX2 
               
               
                 1560850_at 
                 BC016831 
               
               
                 230472_at 
                 AI870306 
                 Hs.424156 
                 IRX1 
               
               
                 238021_s_at 
                 AA954994 
                 Hs.237396 
                 hCG_1815491 
               
               
                 229476_s_at 
                 AW272342 
                 Hs.591969 
                 THRSP 
               
               
                 204942_s_at 
                 NM_000695 
                 Hs.87539 
                 ALDH3B2 
               
               
                 219197_s_at 
                 AI424243 
                 Hs.523468 
                 SCUBE2 
               
               
                 201525_at 
                 NM_001647 
                 Hs.522555 
                 APOD 
               
               
                 219288_at 
                 NM_020685 
                 Hs.47166 
                 C3orf14 
               
               
                 207175_at 
                 NM_004797 
                 Hs.80485 
                 ADIPOQ 
               
               
                 224146_s_at 
                 AF352582 
                 Hs.652267 
                 ABCC11 
               
               
                 227475_at 
                 AI676059 
                 Hs.591352 
                 FOXQ1 
               
               
                 202376_at 
                 NM_001085 
                 Hs.534293 
                 SERPINA3 
               
               
                 237350_at 
                 AW027968 
                 Hs.653449 
                 TTC36 
               
               
                 226560_at 
                 AA576959 
               
               
                 230147_at 
                 AI378647 
                 Hs.42502 
                 F2RL2 
               
               
                 204654_s_at 
                 NM_003220 
                 Hs.519880 
                 TFAP2A 
               
               
                 236534_at 
                 W69365 
                 Hs.591473 
                 BNIPL 
               
               
                 223551_at 
                 AF225513 
                 Hs.486354 
                 PKIB 
               
               
                 205792_at 
                 NM_003881 
                 Hs.592145 
                 WISP2 
               
               
                 237086_at 
                 AI693336 
                 Hs.163484 
                 FOXA1 
               
               
                 224209_s_at 
                 AF019638 
                 Hs.494163 
                 GDA 
               
               
                 202291_s_at 
                 NM_000900 
                 Hs.365706 
                 MGP 
               
               
                 227614_at 
                 W81116 
                 Hs.522988 
                 HKDC1 
               
               
                 229638_at 
                 AI681917 
                 Hs.499205 
                 IRX3 
               
               
                 205286_at 
                 U85658 
                 Hs.473152 
                 TFAP2C 
               
               
                 228481_at 
                 BG541187 
               
               
                 230560_at 
                 N21096 
                 Hs.508958 
                 STXBP6 
               
               
                 204931_at 
                 NM_003206 
                 Hs.78061 
                 TCF21 
               
               
                 209815_at 
                 BG054916 
                 Hs.494538 
                 PTCH1 
               
               
                 203680_at 
                 NM_002736 
                 Hs.433068 
                 PRKAR2B 
               
               
                 240192_at 
                 AI631850 
                 Hs.669736 
                 FLJ45983 
               
               
                 222773_s_at 
                 AA554045 
                 Hs.47099 
                 GALNT12 
               
               
                 203980_at 
                 NM_001442 
                 Hs.391561 
                 FABP4 
               
               
                 1553622_a_at 
                 NM_152597 
                 Hs.129598 
                 FSIP1 
               
               
                 213093_at 
                 AI471375 
                 Hs.531704 
                 PRKCA 
               
               
                 226978_at 
                 AA910945 
                 Hs.103110 
                 PPARA 
               
               
                 214243_s_at 
                 AL450314 
                 Hs.360940 
                 SERHL2 
               
               
                 227376_at 
                 AW021102 
                 Hs.21509 
                 GLI3 
               
               
                 213506_at 
                 BE965369 
                 Hs.154299 
                 F2RL1 
               
               
                 204073_s_at 
                 NM_013279 
                 Hs.473109 
                 C11orf9 
               
               
                 238481_at 
                 AW512787 
                 Hs.365706 
                 MGP 
               
               
                 205313_at 
                 NM_000458 
                 Hs.191144 
                 HNF1B 
               
               
                 230163_at 
                 AW263087 
                 Hs.388347 
                 LOC143381 
               
               
                 203510_at 
                 BG170541 
                 Hs.132966 
                 MET 
               
               
                 243241_at 
                 AW341473 
               
               
                 227550_at 
                 AW242720 
                 Hs.388347 
                 LOC143381 
               
               
                 224458_at 
                 BC006115 
                 Hs.655738 
                 C9orf125 
               
               
                 1555778_a_at 
                 AY140646 
                 Hs.136348 
                 POSTN 
               
               
                 204179_at 
                 NM_005368 
                 Hs.517586 
                 MB 
               
               
                 223122_s_at 
                 AF311912 
                 Hs.481022 
                 SFRP2 
               
               
                 217276_x_at 
                 AL590118 
                 Hs.360940 
                 SERHL2 
               
               
                 217284_x_at 
                 AL589866 
                 Hs.360940 
                 SERHL2 
               
               
                 1556474_a_at 
                 AK095698 
                 Hs.653239 
                 FLJ38379 
               
               
                 227198_at 
                 AW085505 
                 Hs.444414 
                 AFF3 
               
               
                 209341_s_at 
                 AU153366 
                 Hs.656458 
                 IKBKB 
               
               
                 220994_s_at 
                 NM_014178 
                 Hs.508958 
                 STXBP6 
               
               
                 204667_at 
                 NM_004496 
                 Hs.163484 
                 FOXA1 
               
               
                 210809_s_at 
                 D13665 
                 Hs.136348 
                 POSTN 
               
               
                 205476_at 
                 NM_004591 
                 Hs.75498 
                 CCL20 
               
               
                 227174_at 
                 Z98443 
                 Hs.122125 
                 WDR72 
               
               
                 229477_at 
                 AW272342 
                 Hs.591969 
                 THRSP 
               
               
                 223121_s_at 
                 AW003584 
                 Hs.481022 
                 SFRP2 
               
               
                 203843_at 
                 AA906056 
                 Hs.445387 
                 RPS6KA3 
               
               
                 206401_s_at 
                 J03778 
                 Hs.101174 
                 MAPT 
               
               
                 205253_at 
                 NM_002585 
                 Hs.654412 
                 PBX1 
               
               
                 232286_at 
                 AA572675 
               
               
                 204014_at 
                 NM_001394 
                 Hs.417962 
                 DUSP4 
               
               
                 226777_at 
                 AA147933 
               
               
                 213068_at 
                 AI146848 
                 Hs.80552 
                 DPT 
               
               
                 214235_at 
                 X90579 
                 Hs.695915 
                 CYP3A5P2 
               
               
                 229580_at 
                 R71596 
               
               
                 229150_at 
                 AI810764 
               
               
                 223437_at 
                 N48315 
                 Hs.103110 
                 PPARA 
               
               
                 203540_at 
                 NM_002055 
                 Hs.514227 
                 GFAP 
               
               
                 205103_at 
                 NM_006365 
                 Hs.380027 
                 C1orf61 
               
               
                 229259_at 
                 AL133013 
                 Hs.514227 
                 GFAP 
               
               
                 206826_at 
                 NM_002677 
                 Hs.571512 
                 PMP2 
               
               
                 235127_at 
                 AI699994 
                 Hs.571512 
                 PMP2 
               
               
                 228170_at 
                 AL355743 
                 Hs.56663 
                 OLIG1 
               
               
                 231898_x_at 
                 AW026426 
                 Hs.654932 
                 SOX2OT 
               
               
                 219107_at 
                 NM_021948 
                 Hs.516904 
                 BCAN 
               
               
                 203724_s_at 
                 NM_014961 
                 Hs.595749 
                 RUFY3 
               
               
                 223673_at 
                 AF332192 
                 Hs.388827 
                 RFX4 
               
               
                 209469_at 
                 BF939489 
                 Hs.75819 
                 GPM6A 
               
               
                 206397_x_at 
                 NM_001492 
                 Hs.412355 
                 GDF1 
               
               
                 209168_at 
                 AW148844 
                 Hs.495710 
                 GPM6B 
               
               
                 235118_at 
                 AV724769 
               
               
                 204471_at 
                 NM_002045 
                 Hs.134974 
                 GAP43 
               
               
                 210198_s_at 
                 BC002665 
                 Hs.1787 
                 PLP1 
               
               
                 209197_at 
                 AA626780 
                 Hs.32984 
                 SYT11 
               
               
                 206190_at 
                 NM_005291 
                 Hs.46453 
                 GPR17 
               
               
                 213825_at 
                 AA757419 
                 Hs.176977 
                 OLIG2 
               
               
                 230496_at 
                 BE046923 
                 Hs.528335 
                 FAM123A 
               
               
                 209072_at 
                 M13577 
                 Hs.551713 
                 MBP 
               
               
                 209470_s_at 
                 D49958 
                 Hs.75819 
                 GPM6A 
               
               
                 225491_at 
                 AL157452 
                 Hs.502338 
                 SLC1A2 
               
               
                 236761_at 
                 AI939602 
                 Hs.659164 
                 LHFPL3 
               
               
                 209170_s_at 
                 AF016004 
                 Hs.495710 
                 GPM6B 
               
               
                 209169_at 
                 N63576 
                 Hs.495710 
                 GPM6B 
               
               
                 204469_at 
                 NM_002851 
                 Hs.489824 
                 PTPRZ1 
               
               
                 203562_at 
                 NM_005103 
                 Hs.224008 
                 FEZ1 
               
               
                 229921_at 
                 BF196255 
                 Hs.151219 
                 KIF5A 
               
               
                 205143_at 
                 NM_004386 
                 Hs.169047 
                 NCAN 
               
               
                 219415_at 
                 NM_020659 
                 Hs.268728 
                 TTYH1 
               
               
                 209617_s_at 
                 AF035302 
                 Hs.314543 
                 CTNND2 
               
               
                 238850_at 
                 AW015083 
                 Hs.12827 
                 LOC645323 
               
               
                 203526_s_at 
                 M74088 
                 Hs.158932 
                 APC 
               
               
                 222780_s_at 
                 AI870583 
                 Hs.533446 
                 BAALC 
               
               
                 226690_at 
                 AW451961 
                 Hs.377783 
                 ADCYAP1R1 
               
               
                 203151_at 
                 AW296788 
                 Hs.194301 
                 MAP1A 
               
               
                 212636_at 
                 AL031781 
                 Hs.510324 
                 QKI 
               
               
                 235465_at 
                 N66614 
                 Hs.528335 
                 FAM123A 
               
               
                 207323_s_at 
                 NM_002385 
                 Hs.551713 
                 MBP 
               
               
                 227394_at 
                 W94001 
                 Hs.503878 
                 NCAM1 
               
               
                 1552754_a_at 
                 AA640422 
                 Hs.164578 
                 CADM2 
               
               
                 228581_at 
                 AW071744 
                 Hs.408960 
                 KCNJ10 
               
               
                 229875_at 
                 AI363193 
                 Hs.525485 
                 ZDHHC22 
               
               
                 39966_at 
                 AF059274 
                 Hs.45127 
                 CSPG5 
               
               
                 209167_at 
                 AI419030 
                 Hs.495710 
                 GPM6B 
               
               
                 240433_x_at 
                 H39185 
               
               
                 1558388_a_at 
                 R41806 
               
               
                 226281_at 
                 BF059512 
                 Hs.234074 
                 DNER 
               
               
                 1569872_a_at 
                 BC036550 
                 Hs.371980 
                 LOC650392 
               
               
                 206408_at 
                 NM_015564 
                 Hs.656653 
                 LRRTM2 
               
               
                 1561658_at 
                 AF086066 
               
               
                 213395_at 
                 AL022327 
                 Hs.517729 
                 MLC1 
               
               
                 244403_at 
                 R49501 
                 Hs.126135 
                 CRB1 
               
               
                 230272_at 
                 AA464844 
                 Hs.12827 
                 LOC645323 
               
               
                 221236_s_at 
                 NM_030795 
                 Hs.201058 
                 STMN4 
               
               
                 1558189_a_at 
                 BG819064 
                 Hs.554030 
                 LOC284570 
               
               
                 216963_s_at 
                 AF279774 
                 Hs.134974 
                 GAP43 
               
               
                 218899_s_at 
                 NM_024812 
                 Hs.533446 
                 BAALC 
               
               
                 210432_s_at 
                 AF225986 
                 Hs.435274 
                 SCN3A 
               
               
                 209839_at 
                 AL136712 
                 Hs.654775 
                 DNM3 
               
               
                 223603_at 
                 AB026054 
                 Hs.189482 
                 RNF112 
               
               
                 213841_at 
                 BE223030 
               
               
                 227401_at 
                 BE856748 
                 Hs.655142 
                 IL17D 
               
               
                 213721_at 
                 L07335 
                 Hs.518438 
                 SOX2 
               
               
                 238003_at 
                 AI885128 
                 Hs.652245 
                 HEPN1 
               
               
                 213486_at 
                 BF435376 
                 Hs.6421 
                 COPG2 
               
               
                 212843_at 
                 AA126505 
                 Hs.503878 
                 NCAM1 
               
               
                 205344_at 
                 NM_006574 
                 Hs.45127 
                 CSPG5 
               
               
                 210383_at 
                 AF225985 
                 Hs.22654 
                 SCN1A 
               
               
                 227084_at 
                 AW339310 
                 Hs.643454 
                 DTNA 
               
               
                 203525_s_at 
                 AI375486 
                 Hs.158932 
                 APC 
               
               
                 227984_at 
                 BE464483 
                 Hs.371980 
                 LOC650392 
               
               
                 239230_at 
                 AW079166 
                 Hs.57971 
                 HES5 
               
               
                 227612_at 
                 R20763 
                 Hs.1701 
                 ELAVL3 
               
               
                 210066_s_at 
                 D63412 
                 Hs.315369 
                 AQP4 
               
               
                 221623_at 
                 AF229053 
                 Hs.516904 
                 BCAN 
               
               
                 229734_at 
                 BF507379 
                 Hs.504370 
                 LOC283174 
               
               
                 244739_at 
                 AI051769 
                 Hs.263671 
                 RDX 
               
               
                 230144_at 
                 AW294729 
                 Hs.377070 
                 GRIA3 
               
               
                 1558795_at 
                 AL833240 
                 Hs.709829 
                 LOC728052 
               
               
                 230942_at 
                 AI147740 
                 Hs.99272 
                 CMTM5 
               
               
                 213849_s_at 
                 AA974416 
                 Hs.655213 
                 PPP2R2B 
               
               
                 211071_s_at 
                 BC006471 
                 Hs.75823 
                 MLLT11 
               
               
                 226228_at 
                 T15657 
                 Hs.315369 
                 AQP4 
               
               
                 231430_at 
                 AW205640 
                 Hs.448218 
                 FAM181B 
               
               
                 209618_at 
                 U96136 
                 Hs.314543 
                 CTNND2 
               
               
                 222547_at 
                 AL561281 
                 Hs.431550 
                 MAP4K4 
               
               
                 228038_at 
                 AI669815 
                 Hs.518438 
                 SOX2 
               
               
                 226623_at 
                 AI829726 
                 Hs.499704 
                 PHYHIPL 
               
               
                 223536_at 
                 AL136559 
                 Hs.21963 
                 PSD2 
               
               
                 205320_at 
                 NM_005883 
                 Hs.446376 
                 APC2 
               
               
                 207093_s_at 
                 NM_002544 
                 Hs.113874 
                 OMG 
               
               
                 228501_at 
                 BF055343 
                 Hs.411308 
                 GALNTL2 
               
               
                 229799_s_at 
                 AI569787 
                 Hs.503878 
                 NCAM1 
               
               
                 205638_at 
                 NM_001704 
                 Hs.13261 
                 BAI3 
               
               
                 218380_at 
                 NM_021730 
                 Hs.104305 
                 NLRP1 
               
               
                 205737_at 
                 NM_004518 
                 Hs.161851 
                 KCNQ2 
               
               
                 211906_s_at 
                 AB046400 
                 Hs.123035 
                 SERPINB4 
               
               
                 210413_x_at 
                 U19557 
                 Hs.123035 
                 SERPINB4 
               
               
                 209719_x_at 
                 U19556 
                 Hs.227948 
                 SERPINB3 
               
               
                 209720_s_at 
                 BC005224 
                 Hs.227948 
                 SERPINB3 
               
               
                 217272_s_at 
                 AJ001698 
                 Hs.241407 
                 SERPINB13 
               
               
                 214580_x_at 
                 AL569511 
                 Hs.700779 
                 KRT6A 
               
               
                 209125_at 
                 J00269 
                 Hs.700779 
                 KRT6A 
               
               
                 206276_at 
                 NM_003695 
                 Hs.415762 
                 LY6D 
               
               
                 206400_at 
                 NM_002307 
                 Hs.707031 
                 LGALS7 
               
               
                 209126_x_at 
                 L42612 
                 Hs.709235 
                 KRT6B 
               
               
                 211361_s_at 
                 AJ001696 
                 Hs.241407 
                 SERPINB13 
               
               
                 205064_at 
                 NM_003125 
                 Hs.1076 
                 SPRR1B 
               
               
                 216258_s_at 
                 BE148534 
                 Hs.241407 
                 SERPINB13 
               
               
                 216237_s_at 
                 AA807529 
                 Hs.517582 
                 MCM5 
               
               
                 201820_at 
                 NM_000424 
                 Hs.433845 
                 KRT5 
               
               
                 209644_x_at 
                 U38945 
                 Hs.512599 
                 CDKN2A 
               
               
                 203535_at 
                 NM_002965 
                 Hs.112405 
                 S100A9 
               
               
                 209587_at 
                 U70370 
                 Hs.84136 
                 PITX1 
               
               
                 202917_s_at 
                 NM_002964 
                 Hs.416073 
                 S100A8 
               
               
                 204971_at 
                 NM_005213 
                 Hs.518198 
                 CSTA 
               
               
                 206032_at 
                 AI797281 
                 Hs.41690 
                 DSC3 
               
               
                 235075_at 
                 AI813438 
                 Hs.1925 
                 DSG3 
               
               
                 206165_s_at 
                 NM_006536 
                 Hs.241551 
                 CLCA2 
               
               
                 218990_s_at 
                 NM_005416 
                 Hs.139322 
                 SPRR3 
               
               
                 1552487_a_at 
                 NM_001717 
                 Hs.459153 
                 BNC1 
               
               
                 220013_at 
                 NM_024794 
                 Hs.156457 
                 ABHD9 
               
               
                 209800_at 
                 AF061812 
                 Hs.655160 
                 KRT16 
               
               
                 214549_x_at 
                 NM_005987 
                 Hs.46320 
                 SPRR1A 
               
               
                 205349_at 
                 NM_002068 
                 Hs.73797 
                 GNA15 
               
               
                 219554_at 
                 NM_016321 
                 Hs.459284 
                 RHCG 
               
               
                 213680_at 
                 AI831452 
                 Hs.709235 
                 KRT6B 
               
               
                 207039_at 
                 NM_000077 
                 Hs.512599 
                 CDKN2A 
               
               
                 206156_at 
                 NM_005268 
                 Hs.198249 
                 GJB5 
               
               
                 206421_s_at 
                 NM_003784 
                 Hs.138202 
                 SERPINB7 
               
               
                 228575_at 
                 AL578102 
                 Hs.61232 
                 IL20RB 
               
               
                 210020_x_at 
                 M58026 
                 Hs.239600 
                 CALML3 
               
               
                 213240_s_at 
                 X07695 
                 Hs.654610 
                 KRT4 
               
               
                 232082_x_at 
                 BF575466 
                 Hs.139322 
                 SPRR3 
               
               
                 244107_at 
                 AW189097 
               
               
                 221854_at 
                 AI378979 
                 Hs.497350 
                 PKP1 
               
               
                 204952_at 
                 NM_014400 
                 Hs.631594 
                 LYPD3 
               
               
                 206033_s_at 
                 NM_001941 
                 Hs.41690 
                 DSC3 
               
               
                 205595_at 
                 NM_001944 
                 Hs.1925 
                 DSG3 
               
               
                 205916_at 
                 NM_002963 
                 Hs.112408 
                 S100A7 
               
               
                 1559607_s_at 
                 AL703282 
                 Hs.254338 
                 GBP6 
               
               
                 206164_at 
                 NM_006536 
                 Hs.241551 
                 CLCA2 
               
               
                 238603_at 
                 AI611973 
                 Hs.710375 
                 LOC254559 
               
               
                 206122_at 
                 NM_006942 
                 Hs.95582 
                 SOX15 
               
               
                 233064_at 
                 AL365406 
                 Hs.65750 
                 LOC388494 
               
               
                 208502_s_at 
                 NM_002653 
                 Hs.84136 
                 PITX1 
               
               
                 212657_s_at 
                 U65590 
                 Hs.81134 
                 IL1RN 
               
               
                 206166_s_at 
                 AF043977 
                 Hs.241551 
                 CLCA2 
               
               
                 229566_at 
                 AA149250 
                 Hs.463652 
                 LOC645638 
               
               
                 33322_i_at 
                 X57348 
                 Hs.523718 
                 SFN 
               
               
                 39249_at 
                 AB001325 
                 Hs.234642 
                 AQP3 
               
               
                 208153_s_at 
                 NM_001447 
                 Hs.591255 
                 FAT2 
               
               
                 207121_s_at 
                 NM_002748 
                 Hs.411847 
                 MAPK6 
               
               
                 33323_r_at 
                 X57348 
                 Hs.523718 
                 SFN 
               
               
                 201755_at 
                 NM_006739 
                 Hs.517582 
                 MCM5 
               
               
                 236444_x_at 
                 BE785577 
                 Hs.436898 
                 LOC389328 
               
               
                 217528_at 
                 BF003134 
                 Hs.241551 
                 CLCA2 
               
               
                 208539_x_at 
                 NM_006945 
                 Hs.505327 
                 SPRR2D 
               
               
                 211002_s_at 
                 AF230389 
                 Hs.504115 
                 TRIM29 
               
               
                 214370_at 
                 AW238654 
                 Hs.416073 
                 S100A8 
               
               
                 238460_at 
                 AI590662 
                 Hs.379821 
                 FAM83A 
               
               
                 202504_at 
                 NM_012101 
                 Hs.504115 
                 TRIM29 
               
               
                 224204_x_at 
                 AF231339 
                 Hs.434269 
                 ARNTL2 
               
               
                 201202_at 
                 NM_002592 
                 Hs.147433 
                 PCNA 
               
               
                 209260_at 
                 BC000329 
                 Hs.523718 
                 SFN 
               
               
                 204614_at 
                 NM_002575 
                 Hs.594481 
                 SERPINB2 
               
               
                 203747_at 
                 NM_004925 
                 Hs.234642 
                 AQP3 
               
               
                 239430_at 
                 AA195677 
                 Hs.546554 
                 IGFL1 
               
               
                 216243_s_at 
                 BE563442 
                 Hs.81134 
                 IL1RN 
               
               
                 230464_at 
                 AI814092 
                 Hs.501561 
                 S1PR5 
               
               
                 206008_at 
                 NM_000359 
                 Hs.508950 
                 TGM1 
               
               
                 220658_s_at 
                 NM_020183 
                 Hs.434269 
                 ARNTL2 
               
               
                 1559606_at 
                 AL703282 
                 Hs.254338 
                 GBP6 
               
               
                 204252_at 
                 M68520 
                 Hs.19192 
                 CDK2 
               
               
                 211063_s_at 
                 BC006403 
                 Hs.477693 
                 NCK1 
               
               
                 217110_s_at 
                 AJ242547 
                 Hs.369646 
                 MUC4 
               
               
                 220620_at 
                 NM_019060 
                 Hs.110196 
                 CRCT1 
               
               
                 205490_x_at 
                 BF060667 
                 Hs.522561 
                 GJB3 
               
               
                 222892_s_at 
                 AI087937 
                 Hs.475502 
                 TMEM40 
               
               
                 201528_at 
                 BG398414 
                 Hs.461925 
                 RPA1 
               
               
                 208712_at 
                 M73554 
                 Hs.523852 
                 CCND1 
               
               
                 204725_s_at 
                 NM_006153 
                 Hs.477693 
                 NCK1 
               
               
                 217109_at 
                 AJ242547 
                 Hs.369646 
                 MUC4 
               
               
                 227897_at 
                 N20927 
                 Hs.98643 
                 RAP2B 
               
               
                 209932_s_at 
                 U90223 
                 Hs.527980 
                 DUT 
               
               
                 206430_at 
                 NM_001804 
                 Hs.1545 
                 CDX1 
               
               
                 209847_at 
                 U07969 
                 Hs.591853 
                 CDH17 
               
               
                 204272_at 
                 NM_006149 
                 Hs.5302 
                 LGALS4 
               
               
                 206387_at 
                 U51096 
                 Hs.174249 
                 CDX2 
               
               
                 206418_at 
                 NM_007052 
                 Hs.592227 
                 NOX1 
               
               
                 218687_s_at 
                 NM_017648 
                 Hs.5940 
                 MUC13 
               
               
                 214070_s_at 
                 AW006935 
                 Hs.109358 
                 ATP10B 
               
               
                 201884_at 
                 NM_004363 
                 Hs.709196 
                 CEACAM5 
               
               
                 213953_at 
                 AI732381 
                 Hs.84905 
                 KRT20 
               
               
                 222712_s_at 
                 AW451240 
                 Hs.5940 
                 MUC13 
               
               
                 205929_at 
                 NM_005814 
                 Hs.651244 
                 GPA33 
               
               
                 207217_s_at 
                 NM_013955 
                 Hs.592227 
                 NOX1 
               
               
                 228912_at 
                 AI436136 
                 Hs.654595 
                 VIL1 
               
               
                 203903_s_at 
                 NM_014799 
                 Hs.31720 
                 HEPH 
               
               
                 219404_at 
                 NM_024526 
                 Hs.485352 
                 EPS8L3 
               
               
                 207463_x_at 
                 NM_002771 
                 Hs.654513 
                 PRSS3 
               
               
                 213421_x_at 
                 AW007273 
                 Hs.654513 
                 PRSS3 
               
               
                 202831_at 
                 NM_002083 
                 Hs.2704 
                 GPX2 
               
               
                 206312_at 
                 NM_004963 
                 Hs.524278 
                 GUCY2C 
               
               
                 205506_at 
                 NM_007127 
                 Hs.654595 
                 VIL1 
               
               
                 207202_s_at 
                 NM_003889 
                 Hs.7303 
                 NR1I2 
               
               
                 206000_at 
                 NM_005588 
                 Hs.179704 
                 MEP1A 
               
               
                 227867_at 
                 AA005361 
                 Hs.469134 
                 LOC129293 
               
               
                 227676_at 
                 AW001287 
                 Hs.61265 
                 FAM3D 
               
               
                 238143_at 
                 AW001557 
                 Hs.146268 
                 LOC646627 
               
               
                 206199_at 
                 NM_006890 
                 Hs.74466 
                 CEACAM7 
               
               
                 203824_at 
                 NM_004616 
                 Hs.170563 
                 TSPAN8 
               
               
                 210808_s_at 
                 AF166327 
                 Hs.592227 
                 NOX1 
               
               
                 226654_at 
                 AF147790 
                 Hs.489355 
                 MUC12 
               
               
                 214898_x_at 
                 AB038783 
                 Hs.489354 
                 MUC3B 
               
               
                 225835_at 
                 AK025062 
                 Hs.162585 
                 SLC12A2 
               
               
                 60474_at 
                 AA469071 
                 Hs.472054 
                 FERMT1 
               
               
                 238956_at 
                 AA502384 
               
               
                 230772_at 
                 AA639753 
               
               
                 207380_x_at 
                 NM_013954 
                 Hs.592227 
                 NOX1 
               
               
                 218796_at 
                 NM_017671 
                 Hs.472054 
                 FERMT1 
               
               
                 219756_s_at 
                 NM_024921 
                 Hs.267038 
                 POF1B 
               
               
                 210302_s_at 
                 AF262032 
                 Hs.584852 
                 MAB21L2 
               
               
                 240045_at 
                 AI694242 
               
               
                 206143_at 
                 NM_000111 
                 Hs.1650 
                 SLC26A3 
               
               
                 235383_at 
                 AA552060 
                 Hs.154578 
                 MYO7B 
               
               
                 239332_at 
                 AW079559 
               
               
                 228463_at 
                 R99562 
                 Hs.36137 
                 FOXA3 
               
               
                 205632_s_at 
                 NM_003558 
                 Hs.534371 
                 PIP5K1B 
               
               
                 210107_at 
                 AF127036 
                 Hs.194659 
                 CLCA1 
               
               
                 239595_at 
                 AA569032 
                 Hs.2704 
                 GPX2 
               
               
                 211883_x_at 
                 M76742 
                 Hs.512682 
                 CEACAM1 
               
               
                 207850_at 
                 NM_002090 
                 Hs.89690 
                 CXCL3 
               
               
                 215444_s_at 
                 X81006 
                 Hs.493275 
                 TRIM31 
               
               
                 211165_x_at 
                 D31661 
                 Hs.523329 
                 EPHB2 
               
               
                 206698_at 
                 NM_021083 
                 Hs.78919 
                 XK 
               
               
                 212925_at 
                 AA143765 
                 Hs.439180 
                 C19orf21 
               
               
                 218704_at 
                 NM_017763 
                 Hs.656319 
                 RNF43 
               
               
                 201849_at 
                 NM_004052 
                 Hs.144873 
                 BNIP3 
               
               
                 211848_s_at 
                 AF006623 
                 Hs.74466 
                 CEACAM7 
               
               
                 1561421_a_at 
                 AK057259 
               
               
                 229889_at 
                 AW137009 
                 Hs.25425 
                 C17orf76 
               
               
                 1555383_a_at 
                 BC017500 
                 Hs.267038 
                 POF1B 
               
               
                 206286_s_at 
                 NM_003212 
                 Hs.385870 
                 TDGF1 
               
               
                 205043_at 
                 NM_000492 
                 Hs.489786 
                 CFTR 
               
               
                 229215_at 
                 AI393930 
                 Hs.152475 
                 ASCL2 
               
               
                 211882_x_at 
                 U27331 
                 Hs.631846 
                 FUT6 
               
               
                 211657_at 
                 M18728 
                 Hs.466814 
                 CEACAM6 
               
               
                 227850_x_at 
                 AW084544 
                 Hs.415791 
                 CDC42EP5 
               
               
                 205983_at 
                 NM_004413 
                 Hs.109 
                 DPEP1 
               
               
                 201328_at 
                 AL575509 
                 Hs.655628 
                 ETS2 
               
               
                 206797_at 
                 NM_000015 
                 Hs.2 
                 NAT2 
               
               
                 222592_s_at 
                 AW173691 
                 Hs.11638 
                 ACSL5 
               
               
                 203757_s_at 
                 BC005008 
                 Hs.466814 
                 CEACAM6 
               
               
                 224428_s_at 
                 AY029179 
                 Hs.470654 
                 CDCA7 
               
               
                 220645_at 
                 NM_017678 
                 Hs.179100 
                 FAM55D 
               
               
                 232707_at 
                 AK025181 
                 Hs.567637 
                 ISX 
               
               
                 221241_s_at 
                 NM_030766 
                 Hs.210343 
                 BCL2L14 
               
               
                 207259_at 
                 NM_017928 
                 Hs.389460 
                 C17orf73 
               
               
                 207203_s_at 
                 AF061056 
                 Hs.7303 
                 NR1I2 
               
               
                 231693_at 
                 AV655991 
                 Hs.380135 
                 FABP1 
               
               
                 212768_s_at 
                 AL390736 
                 Hs.508113 
                 OLFM4 
               
               
                 211889_x_at 
                 D12502 
                 Hs.512682 
                 CEACAM1 
               
               
                 204454_at 
                 NM_012317 
                 Hs.45231 
                 LDOC1 
               
               
                 230788_at 
                 BF059748 
                 Hs.519884 
                 GCNT2 
               
               
                 223969_s_at 
                 AF323084 
                 Hs.307047 
                 RETNLB 
               
               
                 205190_at 
                 NM_002670 
                 Hs.203637 
                 PLS1 
               
               
                 226226_at 
                 AI282982 
                 Hs.504301 
                 TMEM45B 
               
               
                 209498_at 
                 X16354 
                 Hs.512682 
                 CEACAM1 
               
               
                 231250_at 
                 AI394574 
               
               
                 226461_at 
                 AA204719 
                 Hs.463350 
                 HOXB9 
               
               
                 204623_at 
                 NM_003226 
                 Hs.82961 
                 TFF3 
               
               
                 221879_at 
                 AA886335 
                 Hs.709550 
                 CALML4 
               
               
                 201329_s_at 
                 NM_005239 
                 Hs.655628 
                 ETS2 
               
               
                 218644_at 
                 NM_016445 
                 Hs.170473 
                 PLEK2 
               
               
                 230323_s_at 
                 AW242836 
                 Hs.504301 
                 TMEM45B 
               
               
                 229777_at 
                 AA863031 
                 Hs.242014 
                 CLRN3 
               
               
                 206198_s_at 
                 L31792 
                 Hs.74466 
                 CEACAM7 
               
               
                 208170_s_at 
                 NM_007028 
                 Hs.493275 
                 TRIM31 
               
               
                 209211_at 
                 AF132818 
                 Hs.508234 
                 KLF5 
               
               
                 205932_s_at 
                 NM_002448 
                 Hs.424414 
                 MSX1 
               
               
                 230943_at 
                 AI821669 
                 Hs.98367 
                 SOX17 
               
               
                 219993_at 
                 NM_022454 
                 Hs.98367 
                 SOX17 
               
               
                 213707_s_at 
                 NM_005221 
                 Hs.99348 
                 DLX5 
               
               
                 242940_x_at 
                 AA040332 
                 Hs.249196 
                 DLX6 
               
               
                 231063_at 
                 AW014518 
               
               
                 204086_at 
                 NM_006115 
                 Hs.30743 
                 PRAME 
               
               
                 241291_at 
                 AI922102 
               
               
                 205979_at 
                 NM_002407 
                 Hs.97644 
                 SCGB2A1 
               
               
                 228554_at 
                 AL137566 
                 Hs.32405 
                 PGR 
               
               
                 218857_s_at 
                 NM_025080 
                 Hs.535326 
                 ASRGL1 
               
               
                 226424_at 
                 AI683754 
                 Hs.584744 
                 CAPS 
               
               
                 230882_at 
                 AA129217 
                 Hs.34969 
                 FLJ34048 
               
               
                 231729_s_at 
                 NM_004058 
                 Hs.584744 
                 CAPS 
               
               
                 231728_at 
                 NM_004058 
                 Hs.584744 
                 CAPS 
               
               
                 222764_at 
                 AI928342 
                 Hs.535326 
                 ASRGL1 
               
               
                 205698_s_at 
                 NM_002758 
                 Hs.463978 
                 MAP2K6 
               
               
                 203892_at 
                 NM_006103 
                 Hs.2719 
                 WFDC2 
               
               
                 203221_at 
                 AI758763 
                 Hs.197320 
                 TLE1 
               
               
                 205899_at 
                 NM_003914 
                 Hs.417050 
                 CCNA1 
               
               
                 205225_at 
                 NM_000125 
                 Hs.208124 
                 ESR1 
               
               
                 229095_s_at 
                 AI797263 
                 Hs.535619 
                 LIMS3 
               
               
                 223786_at 
                 AF280086 
                 Hs.655622 
                 CHST6 
               
               
                 228195_at 
                 BE645119 
                 Hs.389311 
                 MGC13057 
               
               
                 1569361_a_at 
                 BC028018 
                 Hs.277215 
                 LOC100129098 
               
               
                 228377_at 
                 AB037805 
                 Hs.446164 
                 KLHL14 
               
               
                 231181_at 
                 AI683621 
               
               
                 204069_at 
                 NM_002398 
                 Hs.526754 
                 MEIS1 
               
               
                 205358_at 
                 NM_000826 
                 Hs.32763 
                 GRIA2 
               
               
                 203222_s_at 
                 NM_005077 
                 Hs.197320 
                 TLE1 
               
               
                 208305_at 
                 NM_000926 
                 Hs.32405 
                 PGR 
               
               
                 209692_at 
                 U71207 
                 Hs.472877 
                 EYA2 
               
               
                 221950_at 
                 AI478455 
                 Hs.202095 
                 EMX2 
               
               
                 219263_at 
                 NM_024539 
                 Hs.496542 
                 RNF128 
               
               
                 205413_at 
                 NM_001584 
                 Hs.289795 
                 MPPED2 
               
               
                 229281_at 
                 N51682 
                 Hs.657892 
                 NPAS3 
               
               
                 229542_at 
                 AW590326 
                 Hs.43977 
                 C20orf85 
               
               
                 230673_at 
                 AV706971 
                 Hs.170128 
                 PKHD1L1 
               
               
                 226462_at 
                 AW134979 
                 Hs.508958 
                 STXBP6 
               
               
                 222281_s_at 
                 AW517716 
               
               
                 227282_at 
                 AB037734 
                 Hs.4993 
                 PCDH19 
               
               
                 1553089_a_at 
                 NM_080736 
                 Hs.2719 
                 WFDC2 
               
               
                 213917_at 
                 BE465829 
                 Hs.469728 
                 PAX8 
               
               
                 242406_at 
                 AI870547 
               
               
                 203423_at 
                 NM_002899 
                 Hs.529571 
                 RBP1 
               
               
                 231077_at 
                 AI798832 
                 Hs.534593 
                 C1orf192 
               
               
                 230412_at 
                 BF196935 
                 Hs.657892 
                 NPAS3 
               
               
                 1559477_s_at 
                 AL832770 
                 Hs.526754 
                 MEIS1 
               
               
                 203961_at 
                 AL157398 
                 Hs.5025 
                 NEBL 
               
               
                 236085_at 
                 AI925136 
                 Hs.55150 
                 CAPSL 
               
               
                 222912_at 
                 BE207758 
                 Hs.503284 
                 ARRB1 
               
               
                 228284_at 
                 BE302305 
                 Hs.197320 
                 TLE1 
               
               
                 204039_at 
                 NM_004364 
                 Hs.699463 
                 CEBPA 
               
               
                 203962_s_at 
                 NM_006393 
                 Hs.5025 
                 NEBL 
               
               
                 240161_s_at 
                 AI470220 
                 Hs.669184 
                 CDC20B 
               
               
                 204058_at 
                 AL049699 
                 Hs.21160 
                 ME1 
               
               
                 203571_s_at 
                 NM_006829 
                 Hs.642660 
                 C10orf116 
               
               
                 211671_s_at 
                 U01351 
                 Hs.122926 
                 NR3C1 
               
               
                 201865_x_at 
                 AI432196 
                 Hs.122926 
                 NR3C1 
               
               
                 201787_at 
                 NM_001996 
                 Hs.24601 
                 FBLN1 
               
               
                 230776_at 
                 N59856 
                 Hs.500643 
                 RNF157 
               
               
                 206893_at 
                 NM_002968 
                 Hs.135787 
                 SALL1 
               
               
                 1553179_at 
                 NM_133638 
                 Hs.23751 
                 ADAMTS19 
               
               
                 204059_s_at 
                 NM_002395 
                 Hs.21160 
                 ME1 
               
               
                 206022_at 
                 NM_000266 
                 Hs.522615 
                 NDP 
               
               
                 1561956_at 
                 AF085947 
               
               
                 240275_at 
                 AI936559 
                 Hs.659807 
                 ARMC3 
               
               
                 229569_at 
                 AW572379 
               
               
                 222334_at 
                 AW979289 
               
               
                 206191_at 
                 NM_001248 
                 Hs.441145 
                 ENTPD3 
               
               
                 229273_at 
                 AU152837 
                 Hs.135787 
                 SALL1 
               
               
                 211235_s_at 
                 AF258450 
                 Hs.208124 
                 ESR1 
               
               
                 209552_at 
                 BC001060 
                 Hs.469728 
                 PAX8 
               
               
                 202628_s_at 
                 NM_000602 
                 Hs.414795 
                 SERPINE1 
               
               
                 229096_at 
                 AI797263 
                 Hs.535619 
                 LIMS3 
               
               
                 221861_at 
                 AL157484 
               
               
                 219764_at 
                 NM_007197 
                 Hs.31664 
                 FZD10 
               
               
                 232531_at 
                 AL137578 
                 Hs.312592 
                 EMX2OS 
               
               
                 216321_s_at 
                 X03348 
                 Hs.122926 
                 NR3C1 
               
               
                 201866_s_at 
                 NM_000176 
                 Hs.122926 
                 NR3C1 
               
               
                 236538_at 
                 BE219628 
                 Hs.32763 
                 GRIA2 
               
               
                 213880_at 
                 AL524520 
                 Hs.658889 
                 LGR5 
               
               
                 201092_at 
                 NM_002893 
                 Hs.495755 
                 RBBP7 
               
               
                 220316_at 
                 NM_022123 
                 Hs.657892 
                 NPAS3 
               
               
                 205906_at 
                 NM_001454 
                 Hs.651204 
                 FOXJ1 
               
               
                 205382_s_at 
                 NM_001928 
                 Hs.155597 
                 CFD 
               
               
                 228035_at 
                 AA453640 
                 Hs.501833 
                 STK33 
               
               
                 238206_at 
                 AI089319 
                 Hs.591686 
                 RXFP1 
               
               
                 206018_at 
                 NM_005249 
                 Hs.695962 
                 FOXG1 
               
               
                 205373_at 
                 NM_004389 
                 Hs.167368 
                 CTNNA2 
               
               
                 203021_at 
                 NM_003064 
                 Hs.517070 
                 SLPI 
               
               
                 226766_at 
                 AB046788 
                 Hs.13305 
                 ROBO2 
               
               
                 202965_s_at 
                 NM_014289 
                 Hs.496593 
                 CAPN6 
               
               
                 219914_at 
                 NM_004826 
                 Hs.26880 
                 ECEL1 
               
               
                 209871_s_at 
                 AB014719 
                 Hs.618112 
                 APBA2 
               
               
                 205348_s_at 
                 NM_004411 
                 Hs.440364 
                 DYNC1I1 
               
               
                 204009_s_at 
                 W80678 
                 Hs.505033 
                 KRAS 
               
               
                 214135_at 
                 BE551219 
                 Hs.655324 
                 CLDN18 
               
               
                 214476_at 
                 NM_005423 
                 Hs.2979 
                 TFF2 
               
               
                 206560_s_at 
                 NM_006533 
                 Hs.646364 
                 MIA 
               
               
                 206334_at 
                 NM_004190 
                 Hs.523130 
                 LIPF 
               
               
                 205927_s_at 
                 NM_001910 
                 Hs.644082 
                 CTSE 
               
               
                 232578_at 
                 BG547464 
                 Hs.655324 
                 CLDN18 
               
               
                 214352_s_at 
                 BF673699 
                 Hs.505033 
                 KRAS 
               
               
                 221133_s_at 
                 NM_016369 
                 Hs.655324 
                 CLDN18 
               
               
                 220191_at 
                 NM_019617 
                 Hs.69319 
                 GKN1 
               
               
                 221132_at 
                 NM_016369 
                 Hs.655324 
                 CLDN18 
               
               
                 219508_at 
                 NM_004751 
                 Hs.194710 
                 GCNT3 
               
               
                 206239_s_at 
                 NM_003122 
                 Hs.407856 
                 SPINK1 
               
               
                 208126_s_at 
                 NM_000772 
                 Hs.511872 
                 CYP2C18 
               
               
                 37433_at 
                 AF077954 
                 Hs.658013 
                 PIAS2 
               
               
                 215103_at 
                 AW192911 
                 Hs.511872 
                 CYP2C18 
               
               
                 204378_at 
                 NM_003657 
                 Hs.400556 
                 BCAS1 
               
               
                 233446_at 
                 AU145336 
                 Hs.194725 
                 ONECUT2 
               
               
                 1559203_s_at 
                 BC029545 
                 Hs.505033 
                 KRAS 
               
               
                 238689_at 
                 BG426455 
                 Hs.256897 
                 GPR110 
               
               
                 230271_at 
                 BG150301 
                 Hs.194725 
                 ONECUT2 
               
               
                 202267_at 
                 NM_005562 
                 Hs.591484 
                 LAMC2 
               
               
                 239911_at 
                 H49805 
                 Hs.194725 
                 ONECUT2 
               
               
                 224367_at 
                 AF251053 
                 Hs.398989 
                 BEX2 
               
               
                 208300_at 
                 NM_002842 
                 Hs.179770 
                 PTPRH 
               
               
                 224476_s_at 
                 BC006219 
                 Hs.447531 
                 MESP1 
               
               
                 230158_at 
                 AA758751 
                 Hs.533644 
                 DPY19L2 
               
               
                 240303_at 
                 BG484769 
                 Hs.115838 
                 TMC5 
               
               
                 220468_at 
                 NM_025047 
                 Hs.287702 
                 ARL14 
               
               
                 204713_s_at 
                 AA910306 
                 Hs.30054 
                 F5 
               
               
                 203819_s_at 
                 AU160004 
                 Hs.700696 
                 IGF2BP3 
               
               
                 1566764_at 
                 AL359055 
                 Hs.598388 
                 7A5 
               
               
                 230100_x_at 
                 AU147145 
                 Hs.435714 
                 PAK1 
               
               
                 219795_at 
                 NM_007231 
                 Hs.522109 
                 SLC6A14 
               
               
                 202864_s_at 
                 NM_003113 
                 Hs.369056 
                 SP100 
               
               
                 218468_s_at 
                 AF154054 
                 Hs.40098 
                 GREM1 
               
               
                 219014_at 
                 NM_016619 
                 Hs.546392 
                 PLAC8 
               
               
                 204855_at 
                 NM_002639 
                 Hs.55279 
                 SERPINB5 
               
               
                 202652_at 
                 NM_001164 
                 Hs.372840 
                 APBB1 
               
               
                 202068_s_at 
                 NM_000527 
                 Hs.213289 
                 LDLR 
               
               
                 219429_at 
                 NM_024306 
                 Hs.461329 
                 FA2H 
               
               
                 243409_at 
                 AI005407 
                 Hs.533830 
                 FOXL1 
               
               
                 206515_at 
                 NM_000896 
                 Hs.106242 
                 CYP4F3 
               
               
                 204537_s_at 
                 NM_004961 
                 Hs.22785 
                 GABRE 
               
               
                 229030_at 
                 AW242997 
                 Hs.291487 
                 CAPN8 
               
               
                 204714_s_at 
                 NM_000130 
                 Hs.30054 
                 F5 
               
               
                 218469_at 
                 NM_013372 
                 Hs.40098 
                 GREM1 
               
               
                 210159_s_at 
                 AF230386 
                 Hs.493275 
                 TRIM31 
               
               
                 231029_at 
                 AI740541 
                 Hs.30054 
                 F5 
               
               
                 209939_x_at 
                 AF005775 
                 Hs.390736 
                 CFLAR 
               
               
                 223694_at 
                 AF220032 
                 Hs.487412 
                 TRIM7 
               
               
                 1556116_s_at 
                 AI825808 
                 Hs.482497 
                 TNPO1 
               
               
                 205402_x_at 
                 NM_002770 
                 Hs.622865 
                 PRSS2 
               
               
                 212444_at 
                 AA156240 
               
               
                 212287_at 
                 BF382924 
                 Hs.462732 
                 SUZ12 
               
               
                 204678_s_at 
                 U90065 
                 Hs.208544 
                 KCNK1 
               
               
                 203964_at 
                 NM_004688 
                 Hs.54483 
                 NMI 
               
               
                 214993_at 
                 AF070642 
                 Hs.655761 
                 ASPHD1 
               
               
                 216470_x_at 
                 AF009664 
                   
                 LOC100134294 
               
               
                 219580_s_at 
                 NM_024780 
                 Hs.115838 
                 TMC5 
               
               
                 210002_at 
                 D87811 
                 Hs.514746 
                 GATA6 
               
               
                 222904_s_at 
                 AW469181 
                 Hs.115838 
                 TMC5 
               
               
                 201468_s_at 
                 NM_000903 
                 Hs.406515 
                 NQO1 
               
               
                 209270_at 
                 L25541 
                 Hs.497636 
                 LAMB3 
               
               
                 203108_at 
                 NM_003979 
                 Hs.631733 
                 GPRC5A 
               
               
                 218806_s_at 
                 AF118887 
                 Hs.267659 
                 VAV3 
               
               
                 206884_s_at 
                 NM_003843 
                 Hs.534699 
                 SCEL 
               
               
                 205261_at 
                 NM_002630 
                 Hs.1867 
                 PGC 
               
               
                 224590_at 
                 BE644917 
                 Hs.529901 
                 XIST 
               
               
                 209310_s_at 
                 U25804 
                 Hs.138378 
                 CASP4 
               
               
                 227733_at 
                 AA928939 
                 Hs.593722 
                 TMEM63C 
               
               
                 209368_at 
                 AF233336 
                 Hs.212088 
                 EPHX2 
               
               
                 210563_x_at 
                 U97075 
                 Hs.390736 
                 CFLAR 
               
               
                 232151_at 
                 AL359055 
                 Hs.598388 
                 7A5 
               
               
                 208505_s_at 
                 NM_000511 
                 Hs.579928 
                 FUT2 
               
               
                 205185_at 
                 NM_006846 
                 Hs.331555 
                 SPINK5 
               
               
                 236163_at 
                 AW136983 
                 Hs.656702 
                 LIX1 
               
               
                 230865_at 
                 N29837 
                 Hs.656702 
                 LIX1 
               
               
                 227426_at 
                 AV702692 
                 Hs.709893 
                 SOS1 
               
               
                 237810_at 
                 AW003929 
                 Hs.533779 
                 CLDN6 
               
               
                 208235_x_at 
                 NM_021123 
                 Hs.460641 
                 GAGE7 
               
               
                 205122_at 
                 BF439316 
                 Hs.598100 
                 TMEFF1 
               
               
                 206067_s_at 
                 NM_024426 
                 Hs.591980 
                 WT1 
               
               
                 231192_at 
                 AW274018 
               
               
                 207739_s_at 
                 NM_001472 
                 Hs.658117 
                 GAGE2C 
               
               
                 207663_x_at 
                 NM_001473 
                   
                 GAGE3 
               
               
                 212780_at 
                 AA700167 
                 Hs.709893 
                 SOS1 
               
               
                 1554460_at 
                 BC027866 
                 Hs.308628 
                 ST8SIA4 
               
               
                 216953_s_at 
                 S75264 
                 Hs.591980 
                 WT1 
               
               
                 206179_s_at 
                 NM_007030 
                 Hs.481466 
                 TPPP 
               
               
                 205177_at 
                 NM_003281 
                 Hs.320890 
                 TNNI1 
               
               
                 208775_at 
                 D89729 
                 Hs.370770 
                 XPO1 
               
               
                 209436_at 
                 AB018305 
                 Hs.705394 
                 SPON1 
               
               
                 206249_at 
                 NM_004721 
                 Hs.656069 
                 MAP3K13 
               
               
                 229221_at 
                 BE467023 
                 Hs.502328 
                 CD44 
               
               
                 213294_at 
                 AV755522 
                 Hs.131431 
                 EIF2AK2 
               
               
                 205901_at 
                 NM_006228 
                 Hs.88218 
                 PNOC 
               
               
                 206439_at 
                 NM_004950 
                 Hs.435680 
                 EPYC 
               
               
                 220816_at 
                 NM_012152 
                 Hs.674915 
                 LPAR3 
               
               
                 210248_at 
                 D83175 
                 Hs.72290 
                 WNT7A 
               
               
                 213993_at 
                 AI885290 
                 Hs.705394 
                 SPON1 
               
               
                 206935_at 
                 NM_002590 
                 Hs.19492 
                 PCDH8 
               
               
                 202097_at 
                 NM_005124 
                 Hs.601591 
                 NUP153 
               
               
                 215987_at 
                 AV654984 
                 Hs.113912 
                 RAPGEF2 
               
               
                 212909_at 
                 AL567376 
                 Hs.714802 
                 LYPD1 
               
               
                 210263_at 
                 AF029780 
                 Hs.23735 
                 KCNF1 
               
               
                 1562981_at 
                 AY034472 
                 Hs.523443 
                 HBB 
               
               
                 204437_s_at 
                 NM_016725 
                 Hs.73769 
                 FOLR1 
               
               
                 214219_x_at 
                 BE646618 
                 Hs.95424 
                 MAP4K1 
               
               
                 235205_at 
                 BF109660 
                 Hs.127286 
                 LOC100128259 
               
               
                 215447_at 
                 AL080215 
                 Hs.516578 
                 TFPI 
               
               
                 213994_s_at 
                 AI885290 
                 Hs.705394 
                 SPON1 
               
               
                 1559239_s_at 
                 AW750026 
                 Hs.232375 
                 ACAT1 
               
               
                 207086_x_at 
                 NM_001474 
                 Hs.460641 
                 GAGE4 
               
               
                 213201_s_at 
                 AJ011712 
                 Hs.631558 
                 TNNT1 
               
               
                 217558_at 
                 BE971373 
                 Hs.282624 
                 CYP2C9 
               
               
                 208477_at 
                 NM_004976 
                 Hs.552896 
                 KCNC1 
               
               
                 233944_at 
                 AU147118 
               
               
                 1552742_at 
                 NM_144633 
                 Hs.475656 
                 KCNH8 
               
               
                 211585_at 
                 U58852 
                 Hs.171061 
                 NPAT 
               
               
                 204836_at 
                 NM_000170 
                 Hs.584238 
                 GLDC 
               
               
                 218309_at 
                 NM_018584 
                 Hs.197922 
                 CAMK2N1 
               
               
                 239381_at 
                 AU155415 
                 Hs.151254 
                 KLK7 
               
               
                 234719_at 
                 AK024889 
                 Hs.436367 
                 LAMA3 
               
               
                 222242_s_at 
                 AF243527 
                 Hs.50915 
                 KLK5 
               
               
                 205473_at 
                 NM_001692 
                 Hs.64173 
                 ATP6V1B1 
               
               
                 207010_at 
                 NM_000812 
                 Hs.27283 
                 GABRB1 
               
               
                 210446_at 
                 M30601 
                 Hs.765 
                 GATA1 
               
               
                 204777_s_at 
                 NM_002371 
                 Hs.80395 
                 MAL 
               
               
                 214598_at 
                 AL049977 
                 Hs.162209 
                 CLDN8 
               
               
                 203844_at 
                 NM_000551 
                 Hs.517792 
                 VHL 
               
               
                 222103_at 
                 AI434345 
                 Hs.648565 
                 ATF1 
               
               
                 222023_at 
                 AK022014 
                 Hs.459211 
                 AKAP13 
               
               
                 242266_x_at 
                 AW973803 
               
               
                 235700_at 
                 AI581344 
                 Hs.535080 
                 RP13-36C9.3 
               
               
                 229163_at 
                 N75559 
                 Hs.197922 
                 CAMK2N1 
               
               
                 225482_at 
                 AL533416 
                 Hs.516802 
                 KIF1A 
               
               
                 243489_at 
                 BF514098 
               
               
                 204456_s_at 
                 AW611727 
                 Hs.65029 
                 GAS1 
               
               
                 224488_s_at 
                 BC006262 
                 Hs.705394 
                 SPON1 
               
               
                 216056_at 
                 AW851559 
                 Hs.502328 
                 CD44 
               
               
                 203876_s_at 
                 AI761713 
                 Hs.143751 
                 MMP11 
               
               
                 206586_at 
                 NM_001841 
                 Hs.73037 
                 CNR2 
               
               
                 205778_at 
                 NM_005046 
                 Hs.151254 
                 KLK7 
               
               
                 214053_at 
                 AW772192 
                 Hs.390729 
                 ERBB4 
               
               
                 222861_x_at 
                 NM_012168 
                 Hs.132753 
                 FBXO2 
               
               
                 238698_at 
                 AI659225 
                 Hs.495984 
                 CASK 
               
               
                 213609_s_at 
                 AB023144 
                 Hs.194766 
                 SEZ6L 
               
               
                 206023_at 
                 NM_006681 
                 Hs.418367 
                 NMU 
               
               
                 223467_at 
                 AF069506 
                 Hs.25829 
                 RASD1 
               
               
                 217133_x_at 
                 X06399 
                 Hs.1360 
                 CYP2B6 
               
               
                 227318_at 
                 AL359605 
               
               
                 227952_at 
                 AI580142 
               
               
                 208198_x_at 
                 NM_014512 
                 Hs.661101 
                 KIR2DS1 
               
               
                 206803_at 
                 NM_024411 
                 Hs.22584 
                 PDYN 
               
               
                 238584_at 
                 W52934 
                 Hs.591594 
                 IQCA1 
               
               
                 224482_s_at 
                 BC006240 
                 Hs.406788 
                 RAB11FIP4 
               
               
                 211029_x_at 
                 BC006245 
                 Hs.87191 
                 FGF18 
               
               
                 1553169_at 
                 BC019612 
                 Hs.149133 
                 LRRN4 
               
               
                 1552575_a_at 
                 NM_153344 
                 Hs.485528 
                 C6or141 
               
               
                 209757_s_at 
                 BC002712 
                 Hs.25960 
                 MYCN 
               
               
                 207004_at 
                 NM_000657 
                 Hs.150749 
                 BCL2 
               
               
                 231489_x_at 
                 H12214 
               
               
                 216261_at 
                 AI151479 
                 Hs.218040 
                 ITGB3 
               
               
                 213150_at 
                 BF792917 
                 Hs.592166 
                 HOXA10 
               
               
                 230835_at 
                 W69083 
                 Hs.112457 
                 KRTDAP 
               
               
                 204636_at 
                 NM_000494 
                 Hs.117938 
                 COL17A1 
               
               
                 216918_s_at 
                 AL096710 
                 Hs.631992 
                 DST 
               
               
                 204455_at 
                 NM_001723 
                 Hs.631992 
                 DST 
               
               
                 209888_s_at 
                 M20643 
                 Hs.187338 
                 MYL1 
               
               
                 214599_at 
                 NM_005547 
                 Hs.516439 
                 IVL 
               
               
                 203872_at 
                 NM_001100 
                 Hs.1288 
                 ACTA1 
               
               
                 224329_s_at 
                 AB049591 
                 Hs.148590 
                 CNFN 
               
               
                 208195_at 
                 NM_003319 
                 Hs.134602 
                 TTN 
               
               
                 209742_s_at 
                 AF020768 
                 Hs.75535 
                 MYL2 
               
               
                 205951_at 
                 NM_005963 
                 Hs.689619 
                 MYH1 
               
               
                 204810_s_at 
                 NM_001824 
                 Hs.334347 
                 CKM 
               
               
                 209351_at 
                 BC002690 
                 Hs.654380 
                 KRT14 
               
               
                 235272_at 
                 AI814274 
                 Hs.433484 
                 SBSN 
               
               
                 204734_at 
                 NM_002275 
                 Hs.654570 
                 KRT15 
               
               
                 213385_at 
                 AK026415 
                 Hs.654611 
                 CHN2 
               
               
                 204631_at 
                 NM_017534 
                 Hs.699445 
                 MYH2 
               
               
                 220414_at 
                 NM_017422 
                 Hs.180142 
                 CALML5 
               
               
                 1556773_at 
                 M31157 
               
               
                 1564307_a_at 
                 AL832750 
                 Hs.620532 
                 A2ML1 
               
               
                 219106_s_at 
                 NM_006063 
                 Hs.50550 
                 KBTBD10 
               
               
                 218689_at 
                 NM_022725 
                 Hs.713574 
                 FANCF 
               
               
                 219995_s_at 
                 NM_024702 
                 Hs.653124 
                 ZNF750 
               
               
                 228794_at 
                 AA211780 
                 Hs.73680 
                 XIRP2 
               
               
                 236119_s_at 
                 AA456642 
                 Hs.490253 
                 SPRR2G 
               
               
                 205485_at 
                 NM_000540 
                 Hs.466664 
                 RYR1 
               
               
                 231331_at 
                 AI085377 
               
               
                 231771_at 
                 AI694073 
                 Hs.511757 
                 GJB6 
               
               
                 221577_x_at 
                 AF003934 
                 Hs.616962 
                 GDF15 
               
               
                 206912_at 
                 NM_004473 
                 Hs.159234 
                 FOXE1 
               
               
                 203861_s_at 
                 AU146889 
                 Hs.498178 
                 ACTN2 
               
               
                 238657_at 
                 T86344 
                 Hs.432503 
                 UBXN10 
               
               
                 232202_at 
                 AK024927 
               
               
                 205444_at 
                 NM_004320 
                 Hs.657344 
                 ATP2A1 
               
               
                 205820_s_at 
                 NM_000040 
                 Hs.73849 
                 APOC3 
               
               
                 219465_at 
                 NM_001643 
                 Hs.237658 
                 APOA2 
               
               
                 1565228_s_at 
                 D16931 
                 Hs.418167 
                 ALB 
               
               
                 205477_s_at 
                 NM_001633 
                 Hs.436911 
                 AMBP 
               
               
                 37020_at 
                 X56692 
                 Hs.76452 
                 CRP 
               
               
                 219466_s_at 
                 NM_001643 
                 Hs.237658 
                 APOA2 
               
               
                 206287_s_at 
                 NM_002218 
                 Hs.709406 
                 ITIH4 
               
               
                 206226_at 
                 NM_000412 
                 Hs.1498 
                 HRG 
               
               
                 205755_at 
                 NM_002217 
                 Hs.76716 
                 ITIH3 
               
               
                 206177_s_at 
                 NM_000045 
                 Hs.440934 
                 ARG1 
               
               
                 204987_at 
                 NM_002216 
                 Hs.75285 
                 ITIH2 
               
               
                 204534_at 
                 NM_000638 
                 Hs.2257 
                 VTN 
               
               
                 1554491_a_at 
                 BC022309 
                 Hs.75599 
                 SERPINC1 
               
               
                 205813_s_at 
                 NM_000429 
                 Hs.282670 
                 MAT1A 
               
               
                 1431_at 
                 J02843 
                 Hs.12907 
                 CYP2E1 
               
               
                 205754_at 
                 NM_000506 
                 Hs.655207 
                 F2 
               
               
                 204551_s_at 
                 NM_001622 
                 Hs.324746 
                 AHSG 
               
               
                 205649_s_at 
                 NM_000508 
                 Hs.351593 
                 FGA 
               
               
                 205500_at 
                 NM_001735 
                 Hs.494997 
                 C5 
               
               
                 206651_s_at 
                 NM_016413 
                 Hs.512937 
                 CPB2 
               
               
                 205216_s_at 
                 NM_000042 
                 Hs.445358 
                 APOH 
               
               
                 206054_at 
                 NM_000893 
                 Hs.77741 
                 KNG1 
               
               
                 210013_at 
                 BC005395 
                 Hs.426485 
                 HPX 
               
               
                 205108_s_at 
                 NM_000384 
                 Hs.120759 
                 APOB 
               
               
                 204965_at 
                 NM_000583 
                 Hs.418497 
                 GC 
               
               
                 206292_s_at 
                 NM_003167 
                 Hs.515835 
                 SULT2A1 
               
               
                 211298_s_at 
                 AF116645 
                 Hs.418167 
                 ALB 
               
               
                 210929_s_at 
                 AF130057 
                 Hs.621361 
                 LOC100131613 
               
               
                 210888_s_at 
                 AF116713 
                 Hs.420257 
                 ITIH1 
               
               
                 207218_at 
                 NM_000133 
                 Hs.522798 
                 F9 
               
               
                 210327_s_at 
                 D13368 
                 Hs.144567 
                 AGXT 
               
               
                 209975_at 
                 AF182276 
                 Hs.12907 
                 CYP2E1 
               
               
                 206727_at 
                 K02766 
                 Hs.654443 
                 C9 
               
               
                 214465_at 
                 NM_000608 
                 Hs.714720 
                 ORM2 
               
               
                 206293_at 
                 U08024 
                 Hs.515835 
                 SULT2A1 
               
               
                 205040_at 
                 NM_000607 
                 Hs.522356 
                 ORM1 
               
               
                 205576_at 
                 NM_000185 
                 Hs.474270 
                 SERPIND1 
               
               
                 209978_s_at 
                 M74220 
                 Hs.143436 
                 PLG 
               
               
                 210798_x_at 
                 AB008047 
                 Hs.655645 
                 MASP2 
               
               
                 217512_at 
                 BG398937 
                 Hs.77741 
                 KNG1 
               
               
                 209976_s_at 
                 AF182276 
                 Hs.12907 
                 CYP2E1 
               
               
                 210215_at 
                 AF067864 
                 Hs.544932 
                 TFR2 
               
               
                 206130_s_at 
                 NM_001181 
                 Hs.654440 
                 ASGR2 
               
               
                 205650_s_at 
                 NM_021871 
                 Hs.351593 
                 FGA 
               
               
                 231678_s_at 
                 AV651117 
                 Hs.1219 
                 ADH4 
               
               
                 205753_at 
                 NM_000567 
                 Hs.76452 
                 CRP 
               
               
                 206979_at 
                 NM_000066 
                 Hs.391835 
                 C8B 
               
               
                 208147_s_at 
                 NM_030878 
                 Hs.709188 
                 CYP2C8 
               
               
                 209977_at 
                 M74220 
                 Hs.143436 
                 PLG 
               
               
                 216238_s_at 
                 BG545288 
                 Hs.300774 
                 FGB 
               
               
                 219803_at 
                 NM_014495 
                 Hs.209153 
                 ANGPTL3 
               
               
                 209660_at 
                 AF162690 
                 Hs.427202 
                 TTR 
               
               
                 214421_x_at 
                 AV652420 
                 Hs.282624 
                 CYP2C9 
               
               
                 223579_s_at 
                 AF119905 
                 Hs.120759 
                 APOB 
               
               
                 216025_x_at 
                 M21940 
                 Hs.282624 
                 CYP2C9 
               
               
                 205041_s_at 
                 NM_000607 
                 Hs.522356 
                 ORM1 
               
               
                 237530_at 
                 T77543 
               
               
                 240033_at 
                 BF447999 
                 Hs.143436 
                 PLG 
               
               
                 207200_at 
                 NM_000531 
                 Hs.117050 
                 OTC 
               
               
                 205302_at 
                 NM_000596 
                 Hs.642938 
                 IGFBP1 
               
               
                 216661_x_at 
                 M15331 
                 Hs.282624 
                 CYP2C9 
               
               
                 217073_x_at 
                 X02162 
                 Hs.633003 
                 APOA1 
               
               
                 206913_at 
                 NM_001701 
                 Hs.284712 
                 BAAT 
               
               
                 228621_at 
                 AA948096 
                 Hs.632436 
                 HFE2 
               
               
                 204450_x_at 
                 NM_000039 
                 Hs.633003 
                 APOA1 
               
               
                 204561_x_at 
                 NM_000483 
                 Hs.75615 
                 APOC2 
               
               
                 210326_at 
                 D13368 
                 Hs.144567 
                 AGXT 
               
               
                 208471_at 
                 NM_020995 
                 Hs.655361 
                 HPR 
               
               
                 204988_at 
                 NM_005141 
                 Hs.300774 
                 FGB 
               
               
                 219612_s_at 
                 NM_000509 
                 Hs.546255 
                 FGG 
               
               
                 208367_x_at 
                 NM_000776 
                 Hs.654391 
                 CYP3A4 
               
               
                 206743_s_at 
                 NM_001671 
                 Hs.12056 
                 ASGR1 
               
               
                 214063_s_at 
                 AI073407 
                 Hs.518267 
                 TF 
               
               
                 231398_at 
                 AA777852 
                 Hs.485438 
                 SLC22A7 
               
               
                 220224_at 
                 NM_017545 
                 Hs.193640 
                 HAO1 
               
               
                 203400_s_at 
                 NM_001063 
                 Hs.518267 
                 TF 
               
               
                 214842_s_at 
                 M12523 
                 Hs.418167 
                 ALB 
               
               
                 207406_at 
                 NM_000780 
                 Hs.1644 
                 CYP7A1 
               
               
                 205152_at 
                 AI003579 
                 Hs.443874 
                 SLC6A1 
               
               
                 207392_x_at 
                 NM_001076 
                 Hs.150207 
                 UGT2B15 
               
               
                 207256_at 
                 NM_000242 
                 Hs.499674 
                 MBL2 
               
               
                 205719_s_at 
                 NM_000277 
                 Hs.643451 
                 PAH 
               
               
                 1554459_s_at 
                 BC020687 
                 Hs.709217 
                 CFHR3 
               
               
                 203179_at 
                 NM_000155 
                 Hs.522090 
                 GALT 
               
               
                 217564_s_at 
                 W80357 
                 Hs.149252 
                 CPS1 
               
               
                 210587_at 
                 BC005161 
                 Hs.632713 
                 INHBE 
               
               
                 216687_x_at 
                 U06641 
                 Hs.150207 
                 UGT2B15 
               
               
                 208209_s_at 
                 NM_000716 
                 Hs.99886 
                 C4BPB 
               
               
                 207858_s_at 
                 NM_000298 
                 Hs.95990 
                 PKLR 
               
               
                 242817_at 
                 BE672390 
                 Hs.282244 
                 PGLYRP2 
               
               
                 205972_at 
                 NM_006841 
                 Hs.76460 
                 SLC38A3 
               
               
                 206259_at 
                 NM_000312 
                 Hs.224698 
                 PROC 
               
               
                 205675_at 
                 AI623321 
                 Hs.195799 
                 MTTP 
               
               
                 230318_at 
                 T62088 
                 Hs.525557 
                 SERPINA1 
               
               
                 213800_at 
                 X04697 
                 Hs.363396 
                 CFH 
               
               
                 215388_s_at 
                 X56210 
                 Hs.575869 
                 CFHR1 
               
               
                 220017_x_at 
                 NM_000771 
                 Hs.282624 
                 CYP2C9 
               
               
                 207819_s_at 
                 NM_000443 
                 Hs.654403 
                 ABCB4 
               
               
                 205982_x_at 
                 NM_003018 
                 Hs.1074 
                 SFTPC 
               
               
                 211735_x_at 
                 BC005913 
                 Hs.1074 
                 SFTPC 
               
               
                 214387_x_at 
                 AA633841 
                 Hs.1074 
                 SFTPC 
               
               
                 37004_at 
                 J02761 
                 Hs.512690 
                 SFTPB 
               
               
                 38691_s_at 
                 J03553 
                 Hs.1074 
                 SFTPC 
               
               
                 209810_at 
                 J02761 
                 Hs.512690 
                 SFTPB 
               
               
                 218835_at 
                 NM_006926 
                 Hs.523084 
                 SFTPA2B 
               
               
                 223678_s_at 
                 M13686 
                 Hs.523084 
                 SFTPA1B 
               
               
                 214199_at 
                 NM_003019 
                 Hs.253495 
                 SFTPD 
               
               
                 223806_s_at 
                 AF090386 
                 Hs.714418 
                 NAPSA 
               
               
                 228979_at 
                 BE218152 
                 Hs.509165 
                 SFTA3 
               
               
                 211024_s_at 
                 BC006221 
                 Hs.705388 
                 NKX2-1 
               
               
                 210068_s_at 
                 U63622 
                 Hs.315369 
                 AQP4 
               
               
                 244056_at 
                 AW293443 
                 Hs.211267 
                 SFTA2 
               
               
                 231315_at 
                 AI807728 
               
               
                 205725_at 
                 NM_003357 
                 Hs.523732 
                 SCGB1A1 
               
               
                 215454_x_at 
                 AI831055 
                 Hs.1074 
                 SFTPC 
               
               
                 230378_at 
                 AA742697 
                 Hs.62492 
                 SCGB3A1 
               
               
                 210906_x_at 
                 U34846 
                 Hs.315369 
                 AQP4 
               
               
                 205654_at 
                 NM_000715 
                 Hs.1012 
                 C4BPA 
               
               
                 243818_at 
                 T96555 
                 Hs.31562 
                 SFTA1P 
               
               
                 226960_at 
                 AW471176 
                 Hs.445586 
                 CXCL17 
               
               
                 220542_s_at 
                 NM_016583 
                 Hs.211092 
                 PLUNC 
               
               
                 230319_at 
                 AI222435 
               
               
                 226067_at 
                 AL355392 
                 Hs.65551 
                 C20orf114 
               
               
                 1566140_at 
                 AK096707 
                 Hs.654864 
                 HOPX 
               
               
                 215059_at 
                 AA053967 
               
               
                 220057_at 
                 NM_020411 
                 Hs.112208 
                 XAGE1D 
               
               
                 229177_at 
                 AI823572 
                 Hs.11782 
                 C16orf89 
               
               
                 204124_at 
                 AF146796 
                 Hs.479372 
                 SLC34A2 
               
               
                 227848_at 
                 AI218954 
                 Hs.491242 
                 PEBP4 
               
               
                 209616_s_at 
                 S73751 
                 Hs.558865 
                 CES1 
               
               
                 240242_at 
                 BE222843 
               
               
                 213695_at 
                 L48516 
                 Hs.440967 
                 PON3 
               
               
                 232765_x_at 
                 AI985918 
                 Hs.447544 
                 LOC146429 
               
               
                 217626_at 
                 BF508244 
                 Hs.460260 
                 AKR1C2 
               
               
                 205819_at 
                 NM_006770 
                 Hs.67726 
                 MARCO 
               
               
                 213674_x_at 
                 AI858004 
                 Hs.510635 
                 IGHG1 
               
               
                 202637_s_at 
                 AI608725 
                 Hs.707983 
                 ICAM1 
               
               
                 234366_x_at 
                 AF103591 
                 Hs.449585 
                 IGL@ 
               
               
                 1555236_a_at 
                 BC042578 
                 Hs.1867 
                 PGC 
               
               
                 204424_s_at 
                 AL050152 
                 Hs.504908 
                 LMO3 
               
               
                 230867_at 
                 AI742521 
                 Hs.591282 
                 COL6A6 
               
               
                 202638_s_at 
                 NM_000201 
                 Hs.707983 
                 ICAM1 
               
               
                 210673_x_at 
                 D50740 
                 Hs.705388 
                 NKX2-1 
               
               
                 215621_s_at 
                 BG340670 
                 Hs.510635 
                 IGHG1 
               
               
                 215946_x_at 
                 AL022324 
                 Hs.567636 
                 IGLL3 
               
               
                 219434_at 
                 NM_018643 
                 Hs.283022 
                 TREM1 
               
               
                 210216_x_at 
                 AF084513 
                 Hs.531879 
                 RAD1 
               
               
                 1555854_at 
                 AA594609 
               
               
                 238017_at 
                 AI440266 
                 Hs.170673 
                 RDHE2 
               
               
                 235568_at 
                 BF433657 
                 Hs.709539 
                 C19orf59 
               
               
                 204811_s_at 
                 NM_006030 
                 Hs.476273 
                 CACNA2D2 
               
               
                 217227_x_at 
                 X93006 
                 Hs.449585 
                 IGL@ 
               
               
                 204460_s_at 
                 AF074717 
                 Hs.531879 
                 RAD1 
               
               
                 216594_x_at 
                 568290 
                 Hs.460260 
                 AKR1C1 
               
               
                 204151_x_at 
                 NM_001353 
                 Hs.460260 
                 AKR1C1 
               
               
                 228504_at 
                 AI828648 
               
               
                 211653_x_at 
                 M33376 
                 Hs.460260 
                 AKR1C2 
               
               
                 209924_at 
                 AB000221 
                 Hs.143961 
                 CCL18 
               
               
                 234350_at 
                 AF127125 
                 Hs.449585 
                 IGLV3-21 
               
               
                 1553605_a_at 
                 NM_152701 
                 Hs.226568 
                 ABCA13 
               
               
                 224342_x_at 
                 L14452 
                 Hs.449585 
                 IGL@ 
               
               
                 209441_at 
                 AY009093 
                 Hs.372688 
                 RHOBTB2 
               
               
                 217258_x_at 
                 AF043583 
                 Hs.449599 
                 IVD 
               
               
                 214651_s_at 
                 U41813 
                 Hs.659350 
                 HOXA9 
               
               
                 209699_x_at 
                 U05598 
                 Hs.460260 
                 AKR1C2 
               
               
                 216430_x_at 
                 AF043586 
                 Hs.449585 
                 IGL@ 
               
               
                 217480_x_at 
                 M20812 
                 Hs.449972 
                 LOC339562 
               
               
                 217179_x_at 
                 X79782 
               
               
                 209905_at 
                 AI246769 
                 Hs.659350 
                 HOXA9 
               
               
                 204081_at 
                 NM_006176 
                 Hs.524116 
                 NRGN 
               
               
                 205866_at 
                 NM_003665 
                 Hs.333383 
                 FCN3 
               
               
                 211881_x_at 
                 AB014341 
                 Hs.449585 
                 IGLJ3 
               
               
                 205623_at 
                 NM_000691 
                 Hs.531682 
                 ALDH3A1 
               
               
                 32128_at 
                 Y13710 
                 Hs.143961 
                 CCL18 
               
               
                 216412_x_at 
                 AF043584 
                 Hs.449599 
                 IVD 
               
               
                 205430_at 
                 AL133386 
                 Hs.296648 
                 BMP5 
               
               
                 220393_at 
                 NM_016571 
                 Hs.149585 
                 GLULD1 
               
               
                 217157_x_at 
                 AF103530 
                 Hs.449621 
                 IGKC 
               
               
                 210096_at 
                 J02871 
                 Hs.436317 
                 CYP4B1 
               
               
                 1553413_at 
                 NM_025011 
                   
                 FLJ13744 
               
               
                 215214_at 
                 H53689 
                 Hs.449585 
                 IGL@ 
               
               
                 203279_at 
                 NM_014674 
                 Hs.224616 
                 EDEM1 
               
               
                 208168_s_at 
                 NM_003465 
                 Hs.201688 
                 CHIT1 
               
               
                 232056_at 
                 AW470178 
                 Hs.534699 
                 SCEL 
               
               
                 227168_at 
                 BF475488 
                 Hs.653712 
                 MIAT 
               
               
                 203159_at 
                 NM_014905 
                 Hs.116448 
                 GLS 
               
               
                 204844_at 
                 L12468 
                 Hs.435765 
                 ENPEP 
               
               
                 204845_s_at 
                 NM_001977 
                 Hs.435765 
                 ENPEP 
               
               
                 205670_at 
                 NM_004861 
                 Hs.17958 
                 GAL3ST1 
               
               
                 205674_x_at 
                 NM_001680 
                 Hs.413137 
                 FXYD2 
               
               
                 205799_s_at 
                 M95548 
                 Hs.112916 
                 SLC3A1 
               
               
                 206119_at 
                 NM_001713 
                 Hs.80756 
                 BHMT 
               
               
                 206963_s_at 
                 NM_016347 
                 Hs.458287 
                 NAT8B 
               
               
                 207298_at 
                 NM_006632 
                 Hs.327179 
                 SLC17A3 
               
               
                 207429_at 
                 NM_003058 
                 Hs.436385 
                 SLC22A2 
               
               
                 207434_s_at 
                 NM_021603 
                 Hs.413137 
                 FXYD2 
               
               
                 210289_at 
                 AB013094 
                 Hs.14637 
                 NAT8 
               
               
                 214069_at 
                 AA865601 
                 Hs.298252 
                 ACSM2B 
               
               
                 222071_s_at 
                 BE552428 
                 Hs.127648 
                 SLCO4C1 
               
               
                 223784_at 
                 AF229179 
                 Hs.129614 
                 TMEM27 
               
               
                 228780_at 
                 AW149422 
               
               
                 230184_at 
                 AL035834 
               
               
                 230554_at 
                 AV696234 
                 Hs.298252 
                 ACSM2B 
               
               
                 237058_x_at 
                 AI802118 
                 Hs.504398 
                 SLC6A13 
               
               
                 237328_at 
                 AI927063 
               
               
                 230920_at 
                 BF060736 
                 Hs.61504 
                 LOC284542 
               
               
                 220084_at 
                 NM_018168 
                 Hs.659706 
                 C14orf105 
               
               
                 241914_s_at 
                 AA804293 
                 Hs.298252 
                 ACSM2B 
               
               
                 219902_at 
                 NM_017614 
                 Hs.114172 
                 BHMT2 
               
               
                 231790_at 
                 AA676742 
                 Hs.655653 
                 DMGDH 
               
               
                 223820_at 
                 AY007436 
                 Hs.714875 
                 RBP5 
               
               
                 219564_at 
                 NM_018658 
                 Hs.463985 
                 KCNJ16 
               
               
                 230602_at 
                 AW025340 
                 Hs.655728 
                 ACMSD 
               
               
                 206517_at 
                 NM_004062 
                 Hs.513660 
                 CDH16 
               
               
                 230309_at 
                 BE876610 
               
               
                 203157_s_at 
                 AB020645 
                 Hs.116448 
                 GLS 
               
               
                 222943_at 
                 AW235567 
                 Hs.653107 
                 GBA3 
               
               
                 235774_at 
                 AV699047 
                 Hs.597380 
                 LOC553137 
               
               
                 205978_at 
                 NM_004795 
                 Hs.524953 
                 KL 
               
               
                 231187_at 
                 AI206039 
                 Hs.459187 
                 SLC28A1 
               
               
                 205380_at 
                 NM_002614 
                 Hs.444751 
                 PDZK1 
               
               
                 206340_at 
                 NM_005123 
                 Hs.282735 
                 NR1H4 
               
               
                 228367_at 
                 BE551416 
                 Hs.656805 
                 ALPK2 
               
               
                 219954_s_at 
                 NM_020973 
                 Hs.653107 
                 GBA3 
               
               
                 224179_s_at 
                 AF230095 
                 Hs.129227 
                 MIOX 
               
               
                 222083_at 
                 AW024233 
                 Hs.145384 
                 GLYAT 
               
               
                 1554375_a_at 
                 AF478446 
                 Hs.282735 
                 NR1H4 
               
               
                 230432_at 
                 AI733124 
                 Hs.597380 
                 LOC553137 
               
               
                 220148_at 
                 NM_022568 
                 Hs.486520 
                 ALDH8A1 
               
               
                 244567_at 
                 BG165613 
               
               
                 1557921_s_at 
                 BC013914 
               
               
                 205234_at 
                 NM_004696 
                 Hs.351306 
                 SLC16A4 
               
               
                 239707_at 
                 BF510408 
                 Hs.462418 
                 SLC5A10 
               
               
                 206228_at 
                 AW769732 
                 Hs.155644 
                 PAX2 
               
               
                 237017_s_at 
                 T73002 
               
               
                 244044_at 
                 AV691872 
               
               
                 223610_at 
                 BC002776 
                 Hs.210870 
                 SEMA5B 
               
               
                 229168_at 
                 AI690433 
                 Hs.660026 
                 COL23A1 
               
               
                 230022_at 
                 BF057185 
                 Hs.592064 
                 LOC348174 
               
               
                 229229_at 
                 AJ292204 
                 Hs.34494 
                 AGXT2 
               
               
                 206775_at 
                 NM_001081 
                 Hs.166206 
                 CUBN 
               
               
                 206065_s_at 
                 NM_001385 
                 Hs.443161 
                 DPYS 
               
               
                 205532_s_at 
                 AU151483 
                 Hs.171054 
                 CDH6 
               
               
                 219271_at 
                 NM_024572 
                 Hs.468058 
                 GALNT14 
               
               
                 222938_x_at 
                 AI685421 
                 Hs.486489 
                 ENPP3 
               
               
                 239667_at 
                 AW000967 
                 Hs.112916 
                 SLC3A1 
               
               
                 207052_at 
                 NM_012206 
                 Hs.129711 
                 HAVCR1 
               
               
                 202950_at 
                 NM_001889 
                 Hs.83114 
                 CRYZ 
               
               
                 214803_at 
                 BF344237 
               
               
                 209283_at 
                 AF007162 
                 Hs.408767 
                 CRYAB 
               
               
                 205893_at 
                 NM_014932 
                 Hs.478289 
                 NLGN1 
               
               
                 206836_at 
                 NM_001044 
                 Hs.406 
                 SLC6A3 
               
               
                 203868_s_at 
                 NM_001078 
                 Hs.109225 
                 VCAM1 
               
               
                 218484_at 
                 NM_020142 
                 Hs.75069 
                 NDUFA4L2 
               
               
                 225558_at 
                 R38084 
                 Hs.434996 
                 GIT2 
               
               
                 218353_at 
                 NM_025226 
                 Hs.24950 
                 RGS5 
               
               
                 206030_at 
                 NM_000049 
                 Hs.171142 
                 ASPA 
               
               
                 239860_at 
                 AI311917 
                 Hs.656046 
                 LOC100130232 
               
               
                 240253_at 
                 BF508634 
               
               
                 228739_at 
                 AI139413 
                 Hs.644739 
                 CYS1 
               
               
                 205363_at 
                 NM_003986 
                 Hs.591996 
                 BBOX1 
               
               
                 221009_s_at 
                 NM_016109 
                 Hs.9613 
                 ANGPTL4 
               
               
                 232737_s_at 
                 AL157377 
                 Hs.486489 
                 ENPP3 
               
               
                 220233_at 
                 NM_024907 
                 Hs.531770 
                 FBXO17 
               
               
                 236860_at 
                 BF968482 
                 Hs.643466 
                 NPY6R 
               
               
                 205710_at 
                 NM_004525 
                 Hs.657729 
                 LRP2 
               
               
                 219948_x_at 
                 NM_024743 
                 Hs.122583 
                 UGT2A3 
               
               
                 244472_at 
                 AW291482 
                 Hs.576171 
                 LOC388630 
               
               
                 203158_s_at 
                 AF097493 
                 Hs.116448 
                 GLS 
               
               
                 209122_at 
                 BC005127 
                 Hs.3416 
                 ADFP 
               
               
                 205222_at 
                 NM_001966 
                 Hs.429879 
                 EHHADH 
               
               
                 243168_at 
                 AI916532 
               
               
                 214091_s_at 
                 AW149846 
                 Hs.386793 
                 GPX3 
               
               
                 216733_s_at 
                 X86401 
                 Hs.75335 
                 GATM 
               
               
                 219121_s_at 
                 NM_017697 
                 Hs.487471 
                 RBM35A 
               
               
                 237351_at 
                 AI732190 
               
               
                 230863_at 
                 R73030 
                 Hs.657729 
                 LRP2 
               
               
                 220502_s_at 
                 NM_022444 
                 Hs.489849 
                 SLC13A1 
               
               
                 225846_at 
                 BF001941 
                 Hs.487471 
                 RBM35A 
               
               
                 244723_at 
                 BF510430 
                 Hs.656497 
                 LOC100129488 
               
               
                 242169_at 
                 AA703201 
                 Hs.114172 
                 BHMT2 
               
               
                 226498_at 
                 AA149648 
               
               
                 215244_at 
                 AI479306 
                 Hs.646438 
                 DGCR5 
               
               
                 220100_at 
                 NM_018484 
                 Hs.220844 
                 SLC22A11 
               
               
                 207738_s_at 
                 NM_013436 
                 Hs.603732 
                 NCKAP1 
               
               
                 200765_x_at 
                 NM_001903 
                 Hs.534797 
                 CTNNA1 
               
               
                 201059_at 
                 NM_005231 
                 Hs.596164 
                 CTTN 
               
               
                 210844_x_at 
                 D14705 
                 Hs.534797 
                 CTNNA1 
               
               
                 224813_at 
                 AL523820 
                 Hs.143728 
                 WASL 
               
               
                 205417_s_at 
                 NM_004393 
                 Hs.76111 
                 DAG1 
               
               
                 200602_at 
                 NM_000484 
                 Hs.434980 
                 APP 
               
               
                 205297_s_at 
                 NM_000626 
                 Hs.89575 
                 CD79B 
               
               
                 200764_s_at 
                 AI826881 
                 Hs.534797 
                 CTNNA1 
               
               
                 228592_at 
                 AW474852 
                 Hs.712553 
                 MS4A1 
               
               
                 218311_at 
                 NM_003618 
                 Hs.655750 
                 MAP4K3 
               
               
                 1555779_a_at 
                 M74721 
                 Hs.631567 
                 CD79A 
               
               
                 205861_at 
                 NM_003121 
                 Hs.437905 
                 SPIB 
               
               
                 206255_at 
                 NM_001715 
                 Hs.146591 
                 BLK 
               
               
                 224861_at 
                 AA628423 
                 Hs.269782 
                 GNAQ 
               
               
                 202329_at 
                 NM_004383 
                 Hs.77793 
                 CSK 
               
               
                 235400_at 
                 AL560266 
                 Hs.266331 
                 FCRLA 
               
               
                 230805_at 
                 AA749202 
               
               
                 226216_at 
                 W84556 
                 Hs.465744 
                 INSR 
               
               
                 200606_at 
                 NM_004415 
                 Hs.519873 
                 DSP 
               
               
                 207069_s_at 
                 NM_005585 
                 Hs.153863 
                 SMAD6 
               
               
                 223751_x_at 
                 AF296673 
                 Hs.120551 
                 TLR10 
               
               
                 201286_at 
                 Z48199 
                 Hs.224607 
                 SDC1 
               
               
                 208820_at 
                 AL037339 
                 Hs.395482 
                 PTK2 
               
               
                 214953_s_at 
                 X06989 
                 Hs.434980 
                 APP 
               
               
                 220059_at 
                 NM_012108 
                 Hs.435579 
                 STAP1 
               
               
                 204192_at 
                 NM_001774 
                 Hs.166556 
                 CD37 
               
               
                 224891_at 
                 AV725666 
                 Hs.220950 
                 FOXO3 
               
               
                 209685_s_at 
                 M13975 
                 Hs.460355 
                 PRKCB 
               
               
                 206398_s_at 
                 NM_001770 
                 Hs.652262 
                 CD19 
               
               
                 209995_s_at 
                 BC003574 
                 Hs.2484 
                 TCL1A 
               
               
                 564_at 
                 M69013 
                 Hs.650575 
                 GNA11 
               
               
                 206687_s_at 
                 NM_002831 
                 Hs.63489 
                 PTPN6 
               
               
                 214339_s_at 
                 AA744529 
                 Hs.95424 
                 MAP4K1 
               
               
                 213766_x_at 
                 N36926 
                 Hs.650575 
                 GNA11 
               
               
                 202615_at 
                 BF222895 
                 Hs.269782 
                 GNAQ 
               
               
                 204960_at 
                 NM_005608 
                 Hs.155975 
                 PTPRCAP 
               
               
                 218261_at 
                 NM_005498 
                 Hs.18894 
                 AP1M2 
               
               
                 227522_at 
                 AA209487 
                 Hs.192586 
                 CMBL 
               
               
                 209827_s_at 
                 NM_004513 
                 Hs.459095 
                 IL16 
               
               
                 208731_at 
                 AU158062 
                 Hs.369017 
                 RAB2A 
               
               
                 208683_at 
                 M23254 
                 Hs.350899 
                 CAPN2 
               
               
                 227336_at 
                 AW576405 
                 Hs.372152 
                 DTX1 
               
               
                 210448_s_at 
                 U49396 
                 Hs.408615 
                 P2RX5 
               
               
                 224862_at 
                 BF969428 
                 Hs.269782 
                 GNAQ 
               
               
                 204581_at 
                 NM_001771 
                 Hs.709215 
                 CD22 
               
               
                 205606_at 
                 NM_002336 
                 Hs.584775 
                 LRP6 
               
               
                 205213_at 
                 NM_014716 
                 Hs.337242 
                 CENTB1 
               
               
                 206385_s_at 
                 NM_020987 
                 Hs.499725 
                 ANK3 
               
               
                 212588_at 
                 Y00062 
                 Hs.654514 
                 PTPRC 
               
               
                 201242_s_at 
                 BC000006 
                 Hs.291196 
                 ATP1B1 
               
               
                 205049_s_at 
                 NM_001783 
                 Hs.631567 
                 CD79A 
               
               
                 224499_s_at 
                 BC006296 
                 Hs.149342 
                 AICDA 
               
               
                 206296_x_at 
                 NM_007181 
                 Hs.95424 
                 MAP4K1 
               
               
                 212587_s_at 
                 AI809341 
                 Hs.654514 
                 PTPRC 
               
               
                 223750_s_at 
                 AW665250 
                 Hs.120551 
                 TLR10 
               
               
                 205267_at 
                 NM_006235 
                 Hs.654525 
                 POU2AF1 
               
               
                 205809_s_at 
                 BE504979 
                 Hs.143728 
                 WASL 
               
               
                 230980_x_at 
                 AI307713 
               
               
                 227030_at 
                 BG231773 
               
               
                 225745_at 
                 AV725248 
                 Hs.584775 
                 LRP6 
               
               
                 217422_s_at 
                 X52785 
                 Hs.709215 
                 CD22 
               
               
                 228494_at 
                 AI888150 
                 Hs.21816 
                 PPP1R9A 
               
               
                 214679_x_at 
                 AL110227 
                 Hs.650575 
                 GNA11 
               
               
                 204661_at 
                 NM_001803 
                 Hs.276770 
                 CD52 
               
               
                 207957_s_at 
                 NM_002738 
                 Hs.460355 
                 PRKCB 
               
               
                 201428_at 
                 NM_001305 
                 Hs.647036 
                 CLDN4 
               
               
                 201650_at 
                 NM_002276 
                 Hs.654568 
                 KRT19 
               
               
                 205544_s_at 
                 NM_001877 
                 Hs.445757 
                 CR2 
               
               
                 40562_at 
                 AF011499 
                 Hs.650575 
                 GNA11 
               
               
                 228051_at 
                 AI979261 
                 Hs.194408 
                 LOC202451 
               
               
                 34210_at 
                 N90866 
                 Hs.276770 
                 CD52 
               
               
                 211945_s_at 
                 BG500301 
                 Hs.713531 
                 ITGB1 
               
               
                 228188_at 
                 AI860150 
                 Hs.220971 
                 FOSL2 
               
               
                 213944_x_at 
                 BG236220 
                 Hs.650575 
                 GNA11 
               
               
                 209135_at 
                 AF289489 
                 Hs.622998 
                 ASPH 
               
               
                 204248_at 
                 NM_002067 
                 Hs.650575 
                 GNA11 
               
               
                 212285_s_at 
                 AW008051 
                 Hs.273330 
                 AGRN 
               
               
                 204961_s_at 
                 NM_000265 
                 Hs.647047 
                 NCF1 
               
               
                 201453_x_at 
                 NM_005614 
                 Hs.283521 
                 RHEB 
               
               
                 205504_at 
                 NM_000061 
                 Hs.159494 
                 BTK 
               
               
                 228056_s_at 
                 AI763426 
                 Hs.636624 
                 NAPSB 
               
               
                 204951_at 
                 NM_004310 
                 Hs.654594 
                 RHOH 
               
               
                 227677_at 
                 BF512748 
                 Hs.515247 
                 JAK3 
               
               
                 226863_at 
                 AI674565 
                 Hs.8379 
                 FAM110C 
               
               
                 235503_at 
                 BF589787 
                 Hs.591712 
                 ASB5 
               
               
                 209990_s_at 
                 AF056085 
                 Hs.198612 
                 GABBR2 
               
               
                 227397_at 
                 AA531086 
                 Hs.300772 
                 TPM2 
               
               
                 213573_at 
                 AA861608 
                 Hs.532793 
                 KPNB1 
               
               
                 239767_at 
                 W72323 
               
               
                 203660_s_at 
                 NM_006031 
                 Hs.474069 
                 PCNT 
               
               
                 217077_s_at 
                 AF095723 
                 Hs.198612 
                 GABBR2 
               
               
                 213574_s_at 
                 AA861608 
                 Hs.532793 
                 KPNB1 
               
               
                 213803_at 
                 BG545463 
                 Hs.532793 
                 KPNB1 
               
               
                 241350_at 
                 AL533913 
                 Hs.656997 
                 FBXL22 
               
               
                 204851_s_at 
                 AF040254 
                 Hs.34780 
                 DCX 
               
               
                 201957_at 
                 AF324888 
                 Hs.444403 
                 PPP1R12B 
               
               
                 40665_at 
                 M83772 
                 Hs.445350 
                 FMO3 
               
               
                 204850_s_at 
                 NM_000555 
                 Hs.34780 
                 DCX 
               
               
                 210059_s_at 
                 BC000433 
                 Hs.178695 
                 MAPK13 
               
               
                 201958_s_at 
                 NM_002481 
                 Hs.444403 
                 PPP1R12B 
               
               
                 202178_at 
                 NM_002744 
                 Hs.496255 
                 PRKCZ 
               
               
                 216199_s_at 
                 AL109942 
                 Hs.390428 
                 MAP3K4 
               
               
                 211679_x_at 
                 AF095784 
                 Hs.198612 
                 GABBR2 
               
               
                 212654_at 
                 AL566786 
                 Hs.300772 
                 TPM2 
               
               
                 206496_at 
                 NM_006894 
                 Hs.445350 
                 FMO3 
               
               
                 204083_s_at 
                 NM_003289 
                 Hs.300772 
                 TPM2 
               
               
                 228737_at 
                 AA211909 
                 Hs.26608 
                 TOX2 
               
               
                 237206_at 
                 AI452798 
                 Hs.567641 
                 MYOCD 
               
               
                 204089_x_at 
                 NM_006724 
                 Hs.390428 
                 MAP3K4 
               
               
                 233499_at 
                 AI366175 
                 Hs.479658 
                 LRRC7 
               
               
                 214577_at 
                 BG164365 
                 Hs.637017 
                 MAP1B 
               
               
                 229578_at 
                 AA716165 
                 Hs.441737 
                 JPH2 
               
               
                 216331_at 
                 AK022548 
                 Hs.524484 
                 ITGA7 
               
               
                 217946_s_at 
                 NM_016402 
                 Hs.515500 
                 SAE1 
               
               
                 222548_s_at 
                 AL561281 
                 Hs.431550 
                 MAP4K4 
               
               
                 228724_at 
                 N49237 
               
               
                 200931_s_at 
                 NM_014000 
                 Hs.643896 
                 VCL 
               
               
                 204053_x_at 
                 U96180 
                 Hs.500466 
                 PTEN 
               
               
                 211711_s_at 
                 BC005821 
                 Hs.500466 
                 PTEN 
               
               
                 224681_at 
                 BG028884 
                 Hs.487341 
                 GNA12 
               
               
                 202555_s_at 
                 NM_005965 
                 Hs.477375 
                 MYLK 
               
               
                 204159_at 
                 NM_001262 
                 Hs.525324 
                 CDKN2C 
               
               
                 212233_at 
                 AL523076 
                 Hs.637017 
                 MAP1B 
               
               
                 218510_x_at 
                 AI816291 
                 Hs.481704 
                 FAM134B 
               
               
                 227183_at 
                 AI417267 
                 Hs.519666 
                 LOC728264 
               
               
                 201234_at 
                 NM_004517 
                 Hs.5158 
                 ILK 
               
               
                 219829_at 
                 NM_012278 
                 Hs.109999 
                 ITGB1BP2 
               
               
                 218181_s_at 
                 NM_017792 
                 Hs.431550 
                 MAP4K4 
               
               
                 226084_at 
                 AA554833 
                 Hs.637017 
                 MAP1B 
               
               
                 221671_x_at 
                 M63438 
                 Hs.449621 
                 IGKC 
               
               
                 224823_at 
                 AA526844 
                 Hs.477375 
                 MYLK 
               
               
                 244780_at 
                 AI800110 
                 Hs.591604 
                 SGPP2 
               
               
                 235651_at 
                 AV741130 
               
               
                 205549_at 
                 NM_006198 
                 Hs.80296 
                 PCP4 
               
               
                 213596_at 
                 AL050391 
                 Hs.138378 
                 CASP4 
               
               
                 209663_s_at 
                 AF072132 
                 Hs.524484 
                 ITGA7 
               
               
                 212764_at 
                 AI806174 
                 Hs.124503 
                 ZEB1 
               
               
                 204165_at 
                 NM_003931 
                 Hs.75850 
                 WASF1 
               
               
                 205433_at 
                 NM_000055 
                 Hs.420483 
                 BCHE 
               
               
                 223708_at 
                 AF329838 
                 Hs.662633 
                 C1QTNF4 
               
               
                 203951_at 
                 NM_001299 
                 Hs.465929 
                 CNN1 
               
               
                 209991_x_at 
                 AF069755 
                 Hs.198612 
                 GABBR2 
               
               
                 211792_s_at 
                 U17074 
                 Hs.525324 
                 CDKN2C 
               
               
                 227662_at 
                 AA541622 
                 Hs.655519 
                 SYNPO2 
               
               
                 236029_at 
                 AI283093 
                 Hs.98523 
                 FAT3 
               
               
                 238575_at 
                 AI094626 
                 Hs.318775 
                 OSBPL6 
               
               
                 214669_x_at 
                 BG485135 
                 Hs.449621 
                 IGKC 
               
               
                 208694_at 
                 U47077 
                 Hs.491682 
                 PRKDC 
               
               
                 203935_at 
                 NM_001105 
                 Hs.470316 
                 ACVR1 
               
               
                 1553530_a_at 
                 NM_033669 
                 Hs.713531 
                 ITGB1 
               
               
                 227180_at 
                 AW138767 
                 Hs.274256 
                 ELOVL7 
               
               
                 210058_at 
                 BC000433 
                 Hs.178695 
                 MAPK13 
               
               
                 214677_x_at 
                 X57812 
                 Hs.449585 
                 IGLJ3 
               
               
                 222797_at 
                 BF508726 
                 Hs.299315 
                 DPYSL5 
               
               
                 202274_at 
                 NM_001615 
                 Hs.516105 
                 ACTG2 
               
               
                 221651_x_at 
                 BC005332 
                 Hs.449621 
                 IGKC 
               
               
                 1558828_s_at 
                 AL703532 
                 Hs.519666 
                 LOC728264 
               
               
                 201058_s_at 
                 NM_006097 
                 Hs.504687 
                 MYL9 
               
               
                 211430_s_at 
                 M87789 
                 Hs.510635 
                 IGHG3 
               
               
                 200771_at 
                 NM_002293 
                 Hs.609663 
                 LAMC1 
               
               
                 222871_at 
                 BF791631 
                 Hs.10414 
                 KLHDC8A 
               
               
                 204548_at 
                 NM_000349 
                 Hs.521535 
                 STAR 
               
               
                 220196_at 
                 NM_024690 
                 Hs.432676 
                 MUC16 
               
               
                 206125_s_at 
                 NM_007196 
                 Hs.104570 
                 KLK8 
               
               
                 204885_s_at 
                 NM_005823 
                 Hs.408488 
                 MSLN 
               
               
                 209569_x_at 
                 NM_014392 
                 Hs.518595 
                 D4S234E 
               
               
                 209570_s_at 
                 BC001745 
                 Hs.518595 
                 D4S234E 
               
               
                 205624_at 
                 NM_001870 
                 Hs.646 
                 CPA3 
               
               
                 212063_at 
                 BE903880 
                 Hs.502328 
                 CD44 
               
               
                 216474_x_at 
                 AF206667 
                 Hs.405479 
                 TPSAB1 
               
               
                 207134_x_at 
                 NM_024164 
                 Hs.405479 
                 TPSB2 
               
               
                 205128_x_at 
                 NM_000962 
                 Hs.201978 
                 PTGS1 
               
               
                 215813_s_at 
                 S36219 
                 Hs.201978 
                 PTGS1 
               
               
                 207741_x_at 
                 NM_003293 
                 Hs.405479 
                 TPSAB1 
               
               
                 210084_x_at 
                 AF206665 
                 Hs.405479 
                 TPSAB1 
               
               
                 217023_x_at 
                 AF099143 
                 Hs.405479 
                 TPSB2 
               
               
                 204733_at 
                 NM_002774 
                 Hs.79361 
                 KLK6 
               
               
                 205683_x_at 
                 NM_003294 
                 Hs.405479 
                 TPSAB1 
               
               
                 219087_at 
                 NM_017680 
                 Hs.435655 
                 ASPN 
               
               
                 209560_s_at 
                 U15979 
                 Hs.533717 
                 DLK1 
               
               
                 215382_x_at 
                 AF206666 
                 Hs.405479 
                 TPSAB1 
               
               
                 212935_at 
                 AB002360 
                 Hs.170422 
                 MCF2L 
               
               
                 226534_at 
                 AI446414 
                 Hs.1048 
                 KITLG 
               
               
                 204490_s_at 
                 M24915 
                 Hs.502328 
                 CD44 
               
               
                 219873_at 
                 NM_024027 
                 Hs.32603 
                 COLEC11 
               
               
                 229290_at 
                 AI692575 
                 Hs.59761 
                 DAPL1 
               
               
                 217523_at 
                 AV700298 
                 Hs.502328 
                 CD44 
               
               
                 209242_at 
                 AL042588 
                 Hs.201776 
                 PEG3 
               
               
                 229927_at 
                 BE222220 
                 Hs.655520 
                 LEMD1 
               
               
                 210916_s_at 
                 AF098641 
                 Hs.502328 
                 CD44 
               
               
                 203632_s_at 
                 NM_016235 
                 Hs.148685 
                 GPRC5B 
               
               
                 204489_s_at 
                 NM_000610 
                 Hs.502328 
                 CD44 
               
               
                 227769_at 
                 AI703476 
               
               
                 203662_s_at 
                 NM_003275 
                 Hs.494595 
                 TMOD1 
               
               
                 226517_at 
                 AL390172 
                 Hs.438993 
                 BCAT1 
               
               
                 209291_at 
                 AW157094 
                 Hs.519601 
                 ID4 
               
               
                 214528_s_at 
                 NM_013951 
                 Hs.469728 
                 PAX8 
               
               
                 219331_s_at 
                 NM_018203 
                 Hs.10414 
                 KLHDC8A 
               
               
                 225285_at 
                 AK025615 
                 Hs.438993 
                 BCAT1 
               
               
                 225809_at 
                 AI659927 
                 Hs.105460 
                 DKFZP564O0823 
               
               
                 205200_at 
                 NM_003278 
                 Hs.476092 
                 CLEC3B 
               
               
                 209835_x_at 
                 BC004372 
                 Hs.502328 
                 CD44 
               
               
                 242468_at 
                 AA767317 
               
               
                 228360_at 
                 BF060747 
                 Hs.357567 
                 LYPD6B 
               
               
                 202718_at 
                 NM_000597 
                 Hs.438102 
                 IGFBP2 
               
               
                 223496_s_at 
                 AL136609 
                 Hs.97876 
                 CCDC8 
               
               
                 212014_x_at 
                 AI493245 
                 Hs.502328 
                 CD44 
               
               
                 209794_at 
                 AB007871 
                 Hs.654743 
                 SRGAP3 
               
               
                 201288_at 
                 NM_001175 
                 Hs.504877 
                 ARHGDIB 
               
               
                 209243_s_at 
                 AF208967 
                 Hs.201776 
                 PEG3 
               
               
                 205127_at 
                 NM_000962 
                 Hs.201978 
                 PTGS1 
               
               
                 207924_x_at 
                 NM_013992 
                 Hs.469728 
                 PAX8 
               
               
                 223754_at 
                 BC005083 
                 Hs.389311 
                 MGC13057 
               
               
                 223843_at 
                 AB007830 
                 Hs.128856 
                 SCARA3 
               
               
                 213523_at 
                 AI671049 
                 Hs.244723 
                 CCNE1 
               
               
                 205869_at 
                 NM_002769 
                 Hs.713534 
                 PRSS1 
               
               
                 205912_at 
                 NM_000936 
                 Hs.501135 
                 PNLIP 
               
               
                 206446_s_at 
                 NM_001971 
                 Hs.348395 
                 ELA1 
               
               
                 205615_at 
                 NM_001868 
                 Hs.2879 
                 CPA1 
               
               
                 205971_s_at 
                 NM_001906 
                 Hs.610926 
                 CTRB1 
               
               
                 214411_x_at 
                 AW584011 
                 Hs.632211 
                 CTRB2 
               
               
                 206447_at 
                 NM_001971 
                 Hs.348395 
                 ELA1 
               
               
                 206151_x_at 
                 NM_007352 
                 Hs.181289 
                 ELA3B 
               
               
                 210246_s_at 
                 AF087138 
                 Hs.54470 
                 ABCC8 
               
               
                 204035_at 
                 NM_003469 
                 Hs.516726 
                 SCG2 
               
               
                 231646_at 
                 AW473496 
                 Hs.631993 
                 DPCR1 
               
               
                 220106_at 
                 NM_013389 
                 Hs.567486 
                 NPC1L1 
               
               
                 204260_at 
                 NM_001819 
                 Hs.516874 
                 CHGB 
               
               
                 223913_s_at 
                 AB058892 
                 Hs.326728 
                 C19orf30 
               
               
                 206915_at 
                 NM_002509 
                 Hs.516922 
                 NKX2-2 
               
               
                 205513_at 
                 NM_001062 
                 Hs.2012 
                 TCN1 
               
               
                 211766_s_at 
                 BC005989 
                 Hs.423598 
                 PNLIPRP2 
               
               
                 205815_at 
                 NM_002580 
                 Hs.567312 
                 REG3A 
               
               
                 206694_at 
                 NM_006229 
                 Hs.73923 
                 PNLIPRP1 
               
               
                 204870_s_at 
                 NM_002594 
                 Hs.315186 
                 PCSK2 
               
               
                 203001_s_at 
                 NM_007029 
                 Hs.521651 
                 STMN2 
               
               
                 214324_at 
                 BF222483 
                 Hs.53985 
                 GP2 
               
               
                 205422_s_at 
                 NM_004791 
                 Hs.696554 
                 ITGBL1 
               
               
                 231993_at 
                 AK026784 
                 Hs.696554 
                 ITGBL1 
               
               
                 201860_s_at 
                 NM_000930 
                 Hs.491582 
                 PLAT 
               
               
                 223753_s_at 
                 AF312769 
                 Hs.567542 
                 CFC1 
               
               
                 205509_at 
                 NM_001871 
                 Hs.477891 
                 CPB1 
               
               
                 222024_s_at 
                 AK022014 
                 Hs.459211 
                 AKAP13 
               
               
                 202627_s_at 
                 AL574210 
                 Hs.414795 
                 SERPINE1 
               
               
                 224396_s_at 
                 AF316824 
                 Hs.435655 
                 ASPN 
               
               
                 205582_s_at 
                 NM_004121 
                 Hs.437156 
                 GGT5 
               
               
                 210162_s_at 
                 U08015 
                 Hs.534074 
                 NFATC1 
               
               
                 204363_at 
                 NM_001993 
                 Hs.62192 
                 F3 
               
               
                 203000_at 
                 BF967657 
                 Hs.521651 
                 STMN2 
               
               
                 228608_at 
                 N49852 
                 Hs.525146 
                 NALCN 
               
               
                 206282_at 
                 NM_002500 
                 Hs.574626 
                 NEUROD1 
               
               
                 205886_at 
                 NM_006507 
                 Hs.4158 
                 REG1B 
               
               
                 206681_x_at 
                 NM_001502 
                 Hs.53985 
                 GP2 
               
               
                 220275_at 
                 NM_022034 
                 Hs.647182 
                 CUZD1 
               
               
                 241137_at 
                 AW338320 
                 Hs.631993 
                 DPCR1 
               
               
                 205844_at 
                 NM_004666 
                 Hs.12114 
                 VNN1 
               
               
                 209752_at 
                 AF172331 
                 Hs.49407 
                 REG1A 
               
               
                 205941_s_at 
                 AI376003 
                 Hs.520339 
                 COL10A1 
               
               
                 208473_s_at 
                 NM_016295 
                 Hs.53985 
                 GP2 
               
               
                 201109_s_at 
                 AV726673 
                 Hs.164226 
                 THBS1 
               
               
                 221718_s_at 
                 M90360 
                 Hs.459211 
                 AKAP13 
               
               
                 231148_at 
                 AI806131 
                 Hs.99376 
                 IGFL2 
               
               
                 222939_s_at 
                 N30257 
                 Hs.591327 
                 SLC16A10 
               
               
                 227099_s_at 
                 AW276078 
                 Hs.714890 
                 LOC387763 
               
               
                 208850_s_at 
                 AL558479 
                 Hs.644697 
                 THY1 
               
               
                 1558549_s_at 
                 BG120535 
                 Hs.12114 
                 VNN1 
               
               
                 227566_at 
                 AW085558 
                 Hs.504352 
                 HNT 
               
               
                 229459_at 
                 AV723914 
                 Hs.436854 
                 FAM19A5 
               
               
                 219196_at 
                 NM_013243 
                 Hs.232618 
                 SCG3 
               
               
                 227140_at 
                 AI343467 
               
               
                 207412_x_at 
                 NM_001808 
                 Hs.654361 
                 CELP 
               
               
                 222020_s_at 
                 AW117456 
                 Hs.504352 
                 HNT 
               
               
                 210643_at 
                 AF053712 
                 Hs.333791 
                 TNFSF11 
               
               
                 204869_at 
                 AL031664 
                 Hs.315186 
                 PCSK2 
               
               
                 217428_s_at 
                 X98568 
                 Hs.520339 
                 COL10A1 
               
               
                 229655_at 
                 N66656 
                 Hs.436854 
                 FAM19A5 
               
               
                 205266_at 
                 NM_002309 
                 Hs.2250 
                 LIF 
               
               
                 216840_s_at 
                 AK026829 
                 Hs.200841 
                 LAMA2 
               
               
                 207181_s_at 
                 NM_001227 
                 Hs.9216 
                 CASP7 
               
               
                 241450_at 
                 AI224952 
                 Hs.135015 
                 RSPO1 
               
               
                 201436_at 
                 AI742789 
                 Hs.249718 
                 EIF4E 
               
               
                 201437_s_at 
                 NM_001968 
                 Hs.249718 
                 EIF4E 
               
               
                 207058_s_at 
                 NM_004562 
                 Hs.132954 
                 PARK2 
               
               
                 204171_at 
                 NM_003161 
                 Hs.463642 
                 RPS6KB1 
               
               
                 32625_at 
                 X15357 
                 Hs.490330 
                 NPR1 
               
               
                 238815_at 
                 BF529195 
                 Hs.591580 
                 LRRTM1 
               
               
                 1555520_at 
                 BC043542 
                 Hs.494538 
                 PTCH1 
               
               
                 205189_s_at 
                 NM_000136 
                 Hs.494529 
                 FANCC 
               
               
                 236773_at 
                 AI635931 
               
               
                 229147_at 
                 AW070877 
               
               
                 226675_s_at 
                 W80468 
                 Hs.642877 
                 MALAT1 
               
               
                 213143_at 
                 BE856707 
                 Hs.526596 
                 C2orf72 
               
               
                 214448_x_at 
                 NM_002503 
                 Hs.9731 
                 NFKBIB 
               
               
                 232318_s_at 
                 AI680459 
                 Hs.201441 
                 LOC121838 
               
               
                 216623_x_at 
                 AK025084 
                 Hs.460789 
                 TOX3 
               
               
                 225859_at 
                 N30645 
                 Hs.356076 
                 XIAP 
               
               
                 1557651_x_at 
                 AK096127 
                 Hs.632380 
                 GALE 
               
               
                 237736_at 
                 AI569844 
               
               
                 206002_at 
                 NM_005756 
                 Hs.146978 
                 GPR64 
               
               
                 231259_s_at 
                 BE467688 
                 Hs.376071 
                 CCND2 
               
               
                 1565868_at 
                 W96225 
                 Hs.502328 
                 CD44 
               
               
                 219190_s_at 
                 NM_017629 
                 Hs.471492 
                 EIF2C4 
               
               
                 216942_s_at 
                 D28586 
                 Hs.34341 
                 CD58 
               
               
                 201016_at 
                 BE542684 
                 Hs.522590 
                 EIF1AX 
               
               
                 217299_s_at 
                 AK001017 
                 Hs.492208 
                 NBN 
               
               
                 221530_s_at 
                 BE857425 
                 Hs.177841 
                 BHLHB3 
               
               
                 215574_at 
                 AU144294 
               
               
                 223634_at 
                 AF279143 
                 Hs.474711 
                 RASD2 
               
               
                 210688_s_at 
                 BC000185 
                 Hs.503043 
                 CPT1A 
               
               
                 207827_x_at 
                 L36675 
                 Hs.271771 
                 SNCA 
               
               
                 202523_s_at 
                 AI952009 
                 Hs.523009 
                 SPOCK2 
               
               
                 201435_s_at 
                 AW268640 
                 Hs.249718 
                 EIF4E 
               
               
                 201128_s_at 
                 NM_001096 
                 Hs.387567 
                 ACLY 
               
               
                 209799_at 
                 AF100763 
                 Hs.43322 
                 PRKAA1 
               
               
                 211960_s_at 
                 BG261416 
                 Hs.15738 
                 RAB7A 
               
               
                 227556_at 
                 AI094580 
                 Hs.706952 
                 NME7 
               
               
                 214590_s_at 
                 AL545760 
                 Hs.129683 
                 UBE2D1 
               
               
                 1552378_s_at 
                 NM_172037 
                 Hs.244940 
                 RDH10 
               
               
                 204579_at 
                 NM_002011 
                 Hs.165950 
                 FGFR4 
               
               
                 225609_at 
                 AI888037 
                 Hs.271510 
                 GSR 
               
               
                 1558775_s_at 
                 AU142380 
                 Hs.372000 
                 NSMAF 
               
               
                 1559459_at 
                 BC043571 
                 Hs.309149 
                 LOC613266 
               
               
                 218625_at 
                 NM_016588 
                 Hs.103291 
                 NRN1 
               
               
                 201019_s_at 
                 NM_001412 
                 Hs.522590 
                 EIF1AX 
               
               
                 201585_s_at 
                 BG035151 
                 Hs.355934 
                 SFPQ 
               
               
                 207414_s_at 
                 NM_002570 
                 Hs.498494 
                 PCSK6 
               
               
                 214147_at 
                 AL046350 
                 Hs.709710 
                 C1orf175 
               
               
                 224935_at 
                 BG165815 
                 Hs.539684 
                 EIF2S3 
               
               
                 238699_s_at 
                 AI659225 
                 Hs.495984 
                 CASK 
               
               
                 229540_at 
                 R45471 
                 Hs.479396 
                 RBPJ 
               
               
                 204859_s_at 
                 NM_013229 
                 Hs.708112 
                 APAF1 
               
               
                 205770_at 
                 NM_000637 
                 Hs.271510 
                 GSR 
               
               
                 219591_at 
                 NM_016564 
                 Hs.22140 
                 CEND1 
               
               
                 206106_at 
                 AL022328 
                 Hs.432642 
                 MAPK12 
               
               
                 202618_s_at 
                 L37298 
                 Hs.200716 
                 MECP2 
               
               
                 241314_at 
                 AI732874 
               
               
                 202850_at 
                 NM_002858 
                 Hs.700576 
                 ABCD3 
               
               
                 202528_at 
                 NM_000403 
                 Hs.632380 
                 GALE 
               
               
                 202409_at 
                 X07868 
                 Hs.523414 
                 IGF2 
               
               
                 228969_at 
                 AI922323 
                 Hs.530009 
                 AGR2 
               
               
                 209074_s_at 
                 AL050264 
                 Hs.506357 
                 FAM107A 
               
               
                 207300_s_at 
                 NM_000131 
                 Hs.36989 
                 F7 
               
               
                 206536_s_at 
                 U32974 
                 Hs.356076 
                 XIAP 
               
               
                 215530_at 
                 BG484069 
                 Hs.567267 
                 FANCA 
               
               
                 204393_s_at 
                 NM_001099 
                 Hs.433060 
                 ACPP 
               
               
                 204582_s_at 
                 NM_001648 
                 Hs.171995 
                 KLK3 
               
               
                 204583_x_at 
                 U17040 
                 Hs.171995 
                 KLK3 
               
               
                 209706_at 
                 AF247704 
                 Hs.55999 
                 NKX3-1 
               
               
                 209854_s_at 
                 AA595465 
                 Hs.515560 
                 KLK2 
               
               
                 209855_s_at 
                 AF188747 
                 Hs.515560 
                 KLK2 
               
               
                 210339_s_at 
                 BC005196 
                 Hs.515560 
                 KLK2 
               
               
                 239990_at 
                 AI821426 
               
               
                 237077_at 
                 AI821895 
               
               
                 243483_at 
                 AI272941 
                 Hs.366053 
                 TRPM8 
               
               
                 216920_s_at 
                 M27331 
                 Hs.534032 
                 TARP 
               
               
                 215806_x_at 
                 M13231 
                 Hs.534032 
                 TRGC2 
               
               
                 211144_x_at 
                 M30894 
                 Hs.534032 
                 TARP 
               
               
                 207430_s_at 
                 NM_002443 
                 Hs.255462 
                 MSMB 
               
               
                 210297_s_at 
                 U22178 
                 Hs.255462 
                 MSMB 
               
               
                 209813_x_at 
                 M16768 
                 Hs.534032 
                 TRGV9 
               
               
                 206001_at 
                 NM_000905 
                 Hs.1832 
                 NPY 
               
               
                 223557_s_at 
                 AB017269 
                 Hs.144513 
                 TMEFF2 
               
               
                 235445_at 
                 BF965166 
               
               
                 236121_at 
                 AI805082 
                 Hs.501758 
                 OR51E2 
               
               
                 202429_s_at 
                 AL353950 
                 Hs.435512 
                 PPP3CA 
               
               
                 230105_at 
                 BF062550 
                 Hs.66731 
                 HOXB13 
               
               
                 221424_s_at 
                 NM_030774 
                 Hs.501758 
                 OR51E2 
               
               
                 231711_at 
                 BF592752 
                 Hs.433060 
                 ACPP 
               
               
                 202457_s_at 
                 AA911231 
                 Hs.435512 
                 PPP3CA 
               
               
                 209844_at 
                 U57052 
                 Hs.66731 
                 HOXB13 
               
               
                 33767_at 
                 X15306 
                 Hs.198760 
                 NEFH 
               
               
                 242649_x_at 
                 AI928428 
                 Hs.574240 
                 C15orf21 
               
               
                 1561817_at 
                 BF681305 
               
               
                 232482_at 
                 AF311306 
                 Hs.501758 
                 OR51E2 
               
               
                 211303_x_at 
                 AF261715 
                 Hs.645352 
                 PSMAL 
               
               
                 215363_x_at 
                 AW168915 
                 Hs.654487 
                 FOLH1 
               
               
                 237030_at 
                 AI659898 
                 Hs.433060 
                 ACPP 
               
               
                 205564_at 
                 NM_007003 
                 Hs.441038 
                 PAGE4 
               
               
                 236256_at 
                 AW993690 
               
               
                 220116_at 
                 NM_021614 
                 Hs.98280 
                 KCNN2 
               
               
                 204412_s_at 
                 NM_021076 
                 Hs.198760 
                 NEFH 
               
               
                 230784_at 
                 BG498699 
                 Hs.116467 
                 C17orf92 
               
               
                 230896_at 
                 AA833830 
                 Hs.120591 
                 CCDC4 
               
               
                 205860_x_at 
                 NM_004476 
                 Hs.654487 
                 FOLH1 
               
               
                 228796_at 
                 BE645967 
                 Hs.199877 
                 CPNE4 
               
               
                 206260_at 
                 NM_003241 
                 Hs.438265 
                 TGM4 
               
               
                 235342_at 
                 AI808090 
                 Hs.481133 
                 SPOCK3 
               
               
                 207362_at 
                 NM_013309 
                 Hs.162989 
                 SLC30A4 
               
               
                 203946_s_at 
                 U75667 
                 Hs.708024 
                 ARG2 
               
               
                 231783_at 
                 AI500293 
                 Hs.632119 
                 CHRM1 
               
               
                 213920_at 
                 AB006631 
                 Hs.124953 
                 CUX2 
               
               
                 203180_at 
                 NM_000693 
                 Hs.459538 
                 ALDH1A3 
               
               
                 205924_at 
                 BC005035 
                 Hs.123072 
                 RAB3B 
               
               
                 229309_at 
                 AI625747 
                 Hs.99913 
                 ADRB1 
               
               
                 214087_s_at 
                 BF593509 
                 Hs.654589 
                 MYBPC1 
               
               
                 206167_s_at 
                 NM_001174 
                 Hs.435291 
                 ARHGAP6 
               
               
                 231336_at 
                 AI703256 
                 Hs.199877 
                 CPNE4 
               
               
                 227827_at 
                 AW138143 
               
               
                 227826_s_at 
                 AW138143 
               
               
                 221003_s_at 
                 NM_030925 
                 Hs.87159 
                 CAB39L 
               
               
                 203129_s_at 
                 BF059313 
                 Hs.435557 
                 KIF5C 
               
               
                 235892_at 
                 AI620881 
               
               
                 224393_s_at 
                 AF307451 
                 Hs.209577 
                 CECR6 
               
               
                 227123_at 
                 AU156710 
                 Hs.123072 
                 RAB3B 
               
               
                 202425_x_at 
                 NM_000944 
                 Hs.435512 
                 PPP3CA 
               
               
                 230595_at 
                 BF677651 
                 Hs.9015 
                 LOC572558 
               
               
                 206827_s_at 
                 NM_014274 
                 Hs.302740 
                 TRPV6 
               
               
                 239202_at 
                 BE552383 
               
               
                 220723_s_at 
                 NM_025087 
                 Hs.479703 
                 FLJ21511 
               
               
                 205102_at 
                 NM_005656 
                 Hs.439309 
                 TMPRSS2 
               
               
                 226553_at 
                 AI660243 
                 Hs.439309 
                 TMPRSS2 
               
               
                 219775_s_at 
                 NM_024695 
                 Hs.187694 
                 CPLX3 
               
               
                 206434_at 
                 NM_016950 
                 Hs.481133 
                 SPOCK3 
               
               
                 210328_at 
                 AF101477 
                 Hs.144914 
                 GNMT 
               
               
                 211689_s_at 
                 AF270487 
                 Hs.439309 
                 TMPRSS2 
               
               
                 220724_at 
                 NM_025087 
                 Hs.479703 
                 FLJ21511 
               
               
                 230577_at 
                 AW014022 
               
               
                 203130_s_at 
                 NM_004522 
                 Hs.435557 
                 KIF5C 
               
               
                 205925_s_at 
                 NM_002867 
                 Hs.123072 
                 RAB3B 
               
               
                 230781_at 
                 AI143988 
               
               
                 201495_x_at 
                 AI889739 
                 Hs.460109 
                 MYH11 
               
               
                 231040_at 
                 AW512988 
               
               
                 1569886_a_at 
                 BC040605 
                 Hs.715125 
                 GLB1L3 
               
               
                 205833_s_at 
                 AI770098 
                 Hs.661347 
                 PART1 
               
               
                 201496_x_at 
                 567238 
                 Hs.460109 
                 MYH11 
               
               
                 220187_at 
                 NM_024636 
                 Hs.521008 
                 STEAP4 
               
               
                 37512_at 
                 U89281 
                 Hs.524513 
                 HSD17B6 
               
               
                 205827_at 
                 NM_000729 
                 Hs.458426 
                 CCK 
               
               
                 239858_at 
                 AI973051 
               
               
                 212252_at 
                 AA181179 
                 Hs.297343 
                 CAMKK2 
               
               
                 202222_s_at 
                 NM_001927 
                 Hs.594952 
                 DES 
               
               
                 225987_at 
                 AA650281 
                 Hs.521008 
                 STEAP4 
               
               
                 202363_at 
                 AF231124 
                 Hs.643338 
                 SPOCK1 
               
               
                 232306_at 
                 BG289314 
                 Hs.54973 
                 CDH26 
               
               
                 240331_at 
                 AI820961 
               
               
                 1554547_at 
                 BC036453 
                 Hs.607594 
                 FAM13C1 
               
               
                 228133_s_at 
                 BF732767 
                 Hs.655378 
                 NDE1 
               
               
                 238165_at 
                 AW665629 
                 Hs.711998 
                 LOC100129282 
               
               
                 215432_at 
                 AC003034 
                 Hs.306812 
                 ACSM1 
               
               
                 210213_s_at 
                 AF022229 
                 Hs.654848 
                 EIF6 
               
               
                 207457_s_at 
                 NM_021246 
                 Hs.591792 
                 LY6G6D 
               
               
                 206858_s_at 
                 NM_004503 
                 Hs.549040 
                 HOXC6 
               
               
                 205767_at 
                 NM_001432 
                 Hs.115263 
                 EREG 
               
               
                 214142_at 
                 AI732905 
                 Hs.632195 
                 ZG16 
               
               
                 231341_at 
                 BE670584 
                 Hs.369703 
                 SLC35D3 
               
               
                 231814_at 
                 AK025404 
                 Hs.489355 
                 MUC12 
               
               
                 220834_at 
                 NM_017716 
                 Hs.272789 
                 MS4A12 
               
               
                 211630_s_at 
                 L42531 
                 Hs.82327 
                 GSS 
               
               
                 211729_x_at 
                 BC005902 
                 Hs.488143 
                 BLVRA 
               
               
                 203773_x_at 
                 NM_000712 
                 Hs.488143 
                 BLVRA 
               
               
                 201415_at 
                 NM_000178 
                 Hs.82327 
                 GSS 
               
               
                 203771_s_at 
                 AA740186 
                 Hs.488143 
                 BLVRA 
               
               
                 208726_s_at 
                 BC000461 
                 Hs.429180 
                 EIF2S2 
               
               
                 220056_at 
                 NM_021258 
                 Hs.110915 
                 IL22RA1 
               
               
                 206149_at 
                 NM_022097 
                 Hs.178589 
                 CHP2 
               
               
                 225667_s_at 
                 AI601101 
                 Hs.260855 
                 FAM84A 
               
               
                 215702_s_at 
                 W60595 
                 Hs.489786 
                 CFTR 
               
               
                 227736_at 
                 AA553959 
                 Hs.298713 
                 C10orf99 
               
               
                 205239_at 
                 NM_001657 
                 Hs.270833 
                 AREG 
               
               
                 203116_s_at 
                 NM_000140 
                 Hs.365365 
                 FECH 
               
               
                 227735_s_at 
                 AA553959 
                 Hs.298713 
                 C10orf99 
               
               
                 229358_at 
                 AA628967 
                 Hs.654504 
                 IHH 
               
               
                 203895_at 
                 AL535113 
                 Hs.472101 
                 PLCB4 
               
               
                 205828_at 
                 NM_002422 
                 Hs.375129 
                 MMP3 
               
               
                 243669_s_at 
                 AA502331 
                 Hs.15951 
                 PRAP1 
               
               
                 203649_s_at 
                 NM_000300 
                 Hs.466804 
                 PLA2G2A 
               
               
                 231439_at 
                 AA922936 
               
               
                 206268_at 
                 NM_020997 
                 Hs.654718 
                 LEFTY1 
               
               
                 202762_at 
                 AL049383 
                 Hs.591600 
                 ROCK2 
               
               
                 1553808_a_at 
                 NM_145285 
                 Hs.243272 
                 NKX2-3 
               
               
                 204254_s_at 
                 NM_000376 
                 Hs.524368 
                 VDR 
               
               
                 229481_at 
                 AI990367 
                 Hs.592059 
                 NKD1 
               
               
                 210133_at 
                 D49372 
                 Hs.54460 
                 CCL11 
               
               
                 210390_s_at 
                 AF031587 
                 Hs.272493 
                 CCL15 
               
               
                 235147_at 
                 R56118 
               
               
                 221204_s_at 
                 NM_018058 
                 Hs.500736 
                 CRTAC1 
               
               
                 209877_at 
                 AF010126 
                 Hs.349470 
                 SNCG 
               
               
                 204612_at 
                 NM_006823 
                 Hs.433700 
                 PKIA 
               
               
                 215729_s_at 
                 BE542323 
                 Hs.496843 
                 VGLL1 
               
               
                 203031_s_at 
                 NM_000375 
                 Hs.501376 
                 UROS 
               
               
                 40560_at 
                 U28049 
                 Hs.705451 
                 TBX2 
               
               
                 209156_s_at 
                 AY029208 
                 Hs.420269 
                 COL6A2 
               
               
                 208451_s_at 
                 NM_000592 
                 Hs.534847 
                 C4B 
               
               
                 218692_at 
                 NM_017786 
                 Hs.390738 
                 GOLSYN 
               
               
                 219736_at 
                 NM_018700 
                 Hs.519514 
                 TRIM36 
               
               
                 218532_s_at 
                 NM_019000 
                 Hs.481704 
                 FAM134B 
               
               
                 205630_at 
                 NM_000756 
                 Hs.75294 
                 CRH 
               
               
                 219355_at 
                 NM_018015 
                 Hs.274267 
                 CXorf57 
               
               
                 205487_s_at 
                 NM_016267 
                 Hs.496843 
                 VGLL1 
               
               
                 1554592_a_at 
                 BC028721 
                 Hs.515217 
                 SLC1A6 
               
               
                 212624_s_at 
                 BF339445 
                 Hs.654534 
                 CHN1 
               
               
                 213417_at 
                 AW173045 
                 Hs.705451 
                 TBX2 
               
               
                 202357_s_at 
                 NM_001710 
                 Hs.69771 
                 CFB 
               
               
                 204103_at 
                 NM_002984 
                 Hs.75703 
                 CCL4 
               
               
                 202604_x_at 
                 NM_001110 
                 Hs.578508 
                 ADAM10 
               
               
                 231579_s_at 
                 BE968786 
                 Hs.633514 
                 TIMP2 
               
               
                 202411_at 
                 NM_005532 
                 Hs.532634 
                 IFI27 
               
               
                 224560_at 
                 BF107565 
                 Hs.633514 
                 TIMP2 
               
               
                 238452_at 
                 AI393356 
                 Hs.517422 
                 FCRLB 
               
               
                 226930_at 
                 AI345957 
                 Hs.520525 
                 FNDC1 
               
               
                 203913_s_at 
                 AL574184 
                 Hs.655491 
                 HPGD 
               
               
                 203167_at 
                 NM_003255 
                 Hs.633514 
                 TIMP2 
               
               
                 202844_s_at 
                 AW025261 
                 Hs.528993 
                 RALBP1 
               
               
                 241382_at 
                 W22165 
                 Hs.433150 
                 PCP4L1 
               
               
                 204465_s_at 
                 NM_004692 
                 Hs.500916 
                 INA 
               
               
                 214895_s_at 
                 AU135154 
                 Hs.578508 
                 ADAM10 
               
               
                 202410_x_at 
                 NM_000612 
                 Hs.523414 
                 IGF2 
               
               
                 217165_x_at 
                 M10943 
                 Hs.513626 
                 MT1F 
               
               
                 226864_at 
                 BF245954 
                 Hs.433700 
                 PKIA 
               
               
                 204818_at 
                 NM_002153 
                 Hs.162795 
                 HSD17B2 
               
               
                 243792_x_at 
                 AI281371 
                 Hs.436142 
                 PTPN13 
               
               
                 1557382_x_at 
                 AI659151 
                 Hs.511787 
                 KIAA1975 
               
               
                 225093_at 
                 N66570 
                 Hs.133135 
                 UTRN 
               
               
                 1555497_a_at 
                 AY151049 
                 Hs.436317 
                 CYP4B1 
               
               
                 244692_at 
                 AW025687 
                 Hs.156452 
                 CYP4F22 
               
               
                 202765_s_at 
                 AI264196 
                 Hs.591133 
                 FBN1 
               
               
                 201599_at 
                 NM_000274 
                 Hs.523332 
                 OAT 
               
               
                 203914_x_at 
                 NM_000860 
                 Hs.655491 
                 HPGD 
               
               
                 228806_at 
                 AI218580 
                 Hs.256022 
                 RORC 
               
               
                 211105_s_at 
                 U80918 
                 Hs.534074 
                 NFATC1 
               
               
                 228232_s_at 
                 NM_014312 
                 Hs.112377 
                 VSIG2 
               
               
                 223582_at 
                 AF055084 
                 Hs.591777 
                 GPR98 
               
               
                 211549_s_at 
                 U63296 
                 Hs.655491 
                 HPGD 
               
               
                 205114_s_at 
                 NM_002983 
                 Hs.514107 
                 CCL3 
               
               
                 205081_at 
                 NM_001311 
                 Hs.70327 
                 CRIP1 
               
               
                 217767_at 
                 NM_000064 
                 Hs.529053 
                 C3 
               
               
                 204201_s_at 
                 NM_006264 
                 Hs.436142 
                 PTPN13 
               
               
                 210118_s_at 
                 M15329 
                 Hs.1722 
                 IL1A 
               
               
                 1555349_a_at 
                 L78790 
                 Hs.375957 
                 ITGB2 
               
               
                 204532_x_at 
                 NM_021027 
                 Hs.554822 
                 UGT1A9 
               
               
                 206882_at 
                 NM_005071 
                 Hs.515217 
                 SLC1A6 
               
               
                 211548_s_at 
                 J05594 
                 Hs.655491 
                 HPGD 
               
               
                 206427_s_at 
                 U06654 
                 Hs.154069 
                 MLANA 
               
               
                 205337_at 
                 AL139318 
                 Hs.301865 
                 DCT 
               
               
                 209848_s_at 
                 U01874 
                 Hs.95972 
                 SILV 
               
               
                 210944_s_at 
                 BC003169 
                 Hs.143261 
                 CAPN3 
               
               
                 210138_at 
                 AF074979 
                 Hs.368733 
                 RGS20 
               
               
                 231666_at 
                 AA194168 
                 Hs.42146 
                 PAX3 
               
               
                 209686_at 
                 BC001766 
                 Hs.422181 
                 S100B 
               
               
                 204995_at 
                 AL567411 
                 Hs.500015 
                 CDK5R1 
               
               
                 204466_s_at 
                 BG260394 
                 Hs.271771 
                 SNCA 
               
               
                 209842_at 
                 AI367319 
                 Hs.376984 
                 SOX10 
               
               
                 219412_at 
                 NM_022337 
                 Hs.591975 
                 RAB38 
               
               
                 211546_x_at 
                 L36674 
                 Hs.271771 
                 SNCA 
               
               
                 214475_x_at 
                 AF127764 
                 Hs.143261 
                 CAPN3 
               
               
                 236972_at 
                 AI351421 
                 Hs.279709 
                 TRIM63 
               
               
                 211890_x_at 
                 AF127765 
                 Hs.143261 
                 CAPN3 
               
               
                 206898_at 
                 NM_021153 
                 Hs.42771 
                 CDH19 
               
               
                 235639_at 
                 AL137939 
               
               
                 213693_s_at 
                 AI610869 
                 Hs.89603 
                 MUC1 
               
               
                 207233_s_at 
                 NM_000248 
                 Hs.166017 
                 MITF 
               
               
                 204467_s_at 
                 NM_000345 
                 Hs.271771 
                 SNCA 
               
               
                 206376_at 
                 NM_018057 
                 Hs.44424 
                 SLC6A15 
               
               
                 213638_at 
                 AW054711 
                 Hs.436996 
                 PHACTR1 
               
               
                 209843_s_at 
                 BC002824 
                 Hs.376984 
                 SOX10 
               
               
                 219255_x_at 
                 NM_018725 
                 Hs.654970 
                 IL17RB 
               
               
                 216059_at 
                 U02309 
                 Hs.42146 
                 PAX3 
               
               
                 213355_at 
                 AI989567 
                 Hs.148716 
                 ST3GAL6 
               
               
                 206701_x_at 
                 NM_003991 
                 Hs.82002 
                 EDNRB 
               
               
                 230741_at 
                 AI655467 
               
               
                 223741_s_at 
                 BC004233 
                 Hs.27935 
                 TTYH2 
               
               
                 203348_s_at 
                 BF060791 
                 Hs.43697 
                 ETV5 
               
               
                 226066_at 
                 AL117653 
                 Hs.166017 
                 MITF 
               
               
                 207847_s_at 
                 NM_002456 
                 Hs.89603 
                 MUC1 
               
               
                 218865_at 
                 NM_022746 
                 Hs.497816 
                 MOSC1 
               
               
                 229245_at 
                 AA535361 
                 Hs.253146 
                 PLEKHA6 
               
               
                 209514_s_at 
                 BE502030 
                 Hs.654978 
                 RAB27A 
               
               
                 219274_at 
                 NM_012338 
                 Hs.16529 
                 TSPAN12 
               
               
                 229599_at 
                 AA675917 
                 Hs.390599 
                 LOC440335 
               
               
                 202260_s_at 
                 NM_003165 
                 Hs.288229 
                 STXBP1 
               
               
                 202525_at 
                 NM_002773 
                 Hs.75799 
                 PRSS8 
               
               
                 204273_at 
                 NM_000115 
                 Hs.82002 
                 EDNRB 
               
               
                 206696_at 
                 NM_000273 
                 Hs.74124 
                 GPR143 
               
               
                 227892_at 
                 AA855042 
                 Hs.437039 
                 PRKAA2 
               
               
                 241966_at 
                 N67810 
                 Hs.21213 
                 MYO5A 
               
               
                 205597_at 
                 NM_025257 
                 Hs.335355 
                 SLC44A4 
               
               
                 204955_at 
                 NM_006307 
                 Hs.15154 
                 SRPX 
               
               
                 210951_x_at 
                 AF125393 
                 Hs.654978 
                 RAB27A 
               
               
                 207469_s_at 
                 NM_003662 
                 Hs.495728 
                 PIR 
               
               
                 209442_x_at 
                 AL136710 
                 Hs.499725 
                 ANK3 
               
               
                 224361_s_at 
                 AF250309 
                 Hs.654970 
                 IL17RB 
               
               
                 225728_at 
                 AI659533 
                 Hs.619806 
                 SORBS2 
               
               
                 1557905_s_at 
                 AL552534 
                 Hs.502328 
                 CD44 
               
               
                 212339_at 
                 AL121895 
                 Hs.437422 
                 EPB41L1 
               
               
                 206552_s_at 
                 NM_003182 
                 Hs.2563 
                 TAC1 
               
               
                 231626_at 
                 BE220053 
               
               
                 1568603_at 
                 AI912173 
                 Hs.654933 
                 CADPS 
               
               
                 207074_s_at 
                 NM_003053 
                 Hs.158322 
                 SLC18A1 
               
               
                 214601_at 
                 AI350339 
                 Hs.591999 
                 TPH1 
               
               
                 229300_at 
                 AW590679 
               
               
                 214811_at 
                 AB002316 
                 Hs.657441 
                 RIMBP2 
               
               
                 240236_at 
                 N50117 
                 Hs.477315 
                 STXBP5L 
               
               
                 205999_x_at 
                 AF182273 
                 Hs.654391 
                 CYP3A4 
               
               
                 223810_at 
                 AF252283 
                 Hs.508201 
                 KLHL1 
               
               
                 228598_at 
                 AL538781 
                 Hs.591555 
                 DPP10 
               
               
                 207529_at 
                 NM_021010 
                 Hs.655233 
                 DEFA5 
               
               
                 206135_at 
                 NM_014682 
                 Hs.655499 
                 ST18 
               
               
                 220074_at 
                 NM_017717 
                 Hs.165619 
                 MUPCDH 
               
               
                 216086_at 
                 AB028977 
                 Hs.663229 
                 SV2C 
               
               
                 1568604_a_at 
                 AI912173 
                 Hs.654933 
                 CADPS 
               
               
                 211843_x_at 
                 AF315325 
                 Hs.111944 
                 CYP3A7 
               
               
                 219643_at 
                 NM_018557 
                 Hs.656461 
                 LRP1B 
               
               
                 229944_at 
                 AU153412 
                 Hs.106795 
                 OPRK1 
               
               
                 207814_at 
                 NM_001926 
                 Hs.711 
                 DEFA6 
               
               
                 206664_at 
                 NM_001041 
                 Hs.429596 
                 SI 
               
               
                 215045_at 
                 BC004145 
                 Hs.26047 
                 TNRC4 
               
               
                 219896_at 
                 NM_015722 
                 Hs.148680 
                 CALY 
               
               
                 206773_at 
                 NM_002347 
                 Hs.159590 
                 LY6H 
               
               
                 209462_at 
                 U48437 
                 Hs.74565 
                 APLP1 
               
               
                 239884_at 
                 BE467579 
                 Hs.654933 
                 CADPS 
               
               
                 233950_at 
                 AK000873 
                 Hs.654933 
                 CADPS 
               
               
                 242660_at 
                 AA846789 
                 Hs.662505 
                 LOC100128641 
               
               
                 200697_at 
                 NM_000188 
                 Hs.657990 
                 HK1 
               
               
                 207544_s_at 
                 NM_000672 
                 Hs.586161 
                 ADH6 
               
               
                 243339_at 
                 AI796076 
               
               
                 232321_at 
                 AK026404 
                 Hs.271819 
                 MUC17 
               
               
                 244170_at 
                 H05254 
               
               
                 205825_at 
                 NM_000439 
                 Hs.78977 
                 PCSK1 
               
               
                 1556641_at 
                 AK094547 
                 Hs.596660 
                 SLC7A14 
               
               
                 213438_at 
                 AA995925 
                 Hs.13349 
                 NFASC 
               
               
                 243231_at 
                 N62096 
                 Hs.658702 
                 SLC38A11 
               
               
                 220639_at 
                 NM_024795 
                 Hs.156652 
                 TM4SF20 
               
               
                 230075_at 
                 AV724323 
                 Hs.632832 
                 RAB39B 
               
               
                 206484_s_at 
                 NM_003399 
                 Hs.170499 
                 XPNPEP2 
               
               
                 211357_s_at 
                 BC005314 
                 Hs.530274 
                 ALDOB 
               
               
                 228329_at 
                 AA700440 
                 Hs.477370 
                 DAB1 
               
               
                 230112_at 
                 AB037820 
                 Hs.170388 
                 39876 
               
               
                 230220_at 
                 AI681025 
                 Hs.438914 
                 C2orf21 
               
               
                 239270_at 
                 AL133721 
                 Hs.145404 
                 PLCXD3 
               
               
                 206502_s_at 
                 NM_002196 
                 Hs.89584 
                 INSM1 
               
               
                 207558_s_at 
                 NM_000325 
                 Hs.643588 
                 PITX2 
               
               
                 214157_at 
                 AA401492 
                 Hs.125898 
                 GNAS 
               
               
                 225016_at 
                 N48299 
                 Hs.293274 
                 APCDD1 
               
               
                 219532_at 
                 NM_022726 
                 Hs.101915 
                 ELOVL4 
               
               
                 224355_s_at 
                 AF237905 
                 Hs.150878 
                 MS4A8B 
               
               
                 204874_x_at 
                 NM_003933 
                 Hs.458427 
                 BAIAP3 
               
               
                 205969_at 
                 NM_001086 
                 Hs.506908 
                 AADAC 
               
               
                 239805_at 
                 AW136060 
                 Hs.102307 
                 SLC13A2 
               
               
                 1557146_a_at 
                 T03074 
                 Hs.711586 
                 FLJ32252 
               
               
                 203779_s_at 
                 NM_005797 
                 Hs.116651 
                 MPZL2 
               
               
                 206975_at 
                 NM_000595 
                 Hs.36 
                 LTA 
               
               
                 202508_s_at 
                 NM_003081 
                 Hs.167317 
                 SNAP25 
               
               
                 205626_s_at 
                 NM_004929 
                 Hs.65425 
                 CALB1 
               
               
                 219659_at 
                 AU146927 
                 Hs.444957 
                 ATP8A2 
               
               
                 211483_x_at 
                 AF081924 
                 Hs.351887 
                 CAMK2B 
               
               
                 229818_at 
                 AL359592 
                 Hs.4221 
                 SVOP 
               
               
                 203029_s_at 
                 NM_002847 
                 Hs.490789 
                 PTPRN2 
               
               
                 205390_s_at 
                 NM_000037 
                 Hs.654438 
                 ANK1 
               
               
                 232165_at 
                 AL137725 
                 Hs.200412 
                 EPPK1 
               
               
                 203397_s_at 
                 BF063271 
                 Hs.170986 
                 GALNT3 
               
               
                 206157_at 
                 NM_002852 
                 Hs.591286 
                 PTX3 
               
               
                 232164_s_at 
                 AL137725 
                 Hs.200412 
                 EPPK1 
               
               
                 202005_at 
                 NM_021978 
                 Hs.504315 
                 ST14 
               
               
                 203453_at 
                 NM_001038 
                 Hs.591047 
                 SCNN1A 
               
               
                 213947_s_at 
                 AI867102 
                 Hs.475525 
                 NUP210 
               
               
                 225645_at 
                 AI763378 
                 Hs.653859 
                 EHF 
               
               
                 204038_s_at 
                 NM_001401 
                 Hs.126667 
                 LPAR1 
               
               
                 223232_s_at 
                 AI768894 
                 Hs.591464 
                 CGN 
               
               
                 235548_at 
                 BG326592 
                 Hs.119286 
                 APCDD1L 
               
               
                 211974_x_at 
                 AL513759 
                 Hs.479396 
                 RBPJ 
               
               
                 210105_s_at 
                 M14333 
                 Hs.390567 
                 FYN 
               
               
                 35617_at 
                 U29725 
                 Hs.150136 
                 MAPK7 
               
               
                 226535_at 
                 AK026736 
                 Hs.470399 
                 ITGB6 
               
               
                 204036_at 
                 AW269335 
                 Hs.126667 
                 LPAR1 
               
               
                 220392_at 
                 NM_022659 
                 Hs.710674 
                 EBF2 
               
               
                 226342_at 
                 AW593244 
                 Hs.503178 
                 SPTBN1 
               
               
                 229800_at 
                 AI129626 
                 Hs.507755 
                 DCLK1 
               
               
                 220035_at 
                 NM_024923 
                 Hs.475525 
                 NUP210 
               
               
                 205780_at 
                 NM_001197 
                 Hs.475055 
                 BIK 
               
               
                 226096_at 
                 AI760132 
                 Hs.524234 
                 FNDC5 
               
               
                 201209_at 
                 NM_004964 
                 Hs.88556 
                 HDAC1 
               
               
                 212486_s_at 
                 N20923 
                 Hs.390567 
                 FYN 
               
               
                 219630_at 
                 NM_005764 
                 Hs.431099 
                 PDZK1|P1 
               
               
                 209114_at 
                 AF133425 
                 Hs.38972 
                 TSPAN1 
               
               
                 1553589_a_at 
                 NM_005764 
                 Hs.431099 
                 PDZK1|P1 
               
               
                 230438_at 
                 AI039005 
                 Hs.146196 
                 TBX15 
               
               
                 209012_at 
                 AV718192 
                 Hs.130031 
                 TRIO 
               
               
                 224793_s_at 
                 AA604375 
                 Hs.494622 
                 TGFBR1 
               
               
                 204503_at 
                 NM_001988 
                 Hs.500635 
                 EVPL 
               
               
                 203851_at 
                 NM_002178 
                 Hs.274313 
                 IGFBP6 
               
               
                 222675_s_at 
                 AA628400 
                 Hs.656063 
                 BAIAP2L1 
               
               
                 223423_at 
                 BC000181 
                 Hs.231320 
                 GPR160 
               
               
                 238567_at 
                 AW779536 
                 Hs.591604 
                 SGPP2 
               
               
                 223631_s_at 
                 AF213678 
                 Hs.631544 
                 C19orf33 
               
               
                 218221_at 
                 AL042842 
                 Hs.632446 
                 ARNT 
               
               
                 202489_s_at 
                 BC005238 
                 Hs.301350 
                 FXYD3 
               
               
                 236361_at 
                 BF432376 
                 Hs.411308 
                 GALNTL2 
               
               
                 210135_s_at 
                 AF022654 
                 Hs.55967 
                 SHOX2 
               
               
                 207316_at 
                 NM_001523 
                 Hs.57697 
                 HAS1 
               
               
                 202286_s_at 
                 J04152 
                 Hs.23582 
                 TACSTD2 
               
               
                 219388_at 
                 NM_024915 
                 Hs.661088 
                 GRHL2 
               
               
                 206680_at 
                 NM_005894 
                 Hs.134035 
                 CD5L 
               
               
                 206380_s_at 
                 NM_002621 
                 Hs.53155 
                 CFP 
               
               
                 214074_s_at 
                 BG475299 
                 Hs.596164 
                 CTTN 
               
               
                 221239_s_at 
                 NM_030764 
                 Hs.437393 
                 FCRL2 
               
               
                 205033_s_at 
                 NM_004084 
                 Hs.380781 
                 DEFA1 
               
               
                 228518_at 
                 AW575313 
                 Hs.510635 
                 IGHG1 
               
               
                 209061_at 
                 AI761748 
                 Hs.592142 
                 NCOA3 
               
               
                 206210_s_at 
                 NM_000078 
                 Hs.89538 
                 CETP 
               
               
                 202880_s_at 
                 NM_004762 
                 Hs.191215 
                 CYTH1 
               
               
                 207655_s_at 
                 NM_013314 
                 Hs.665244 
                 BLNK 
               
               
                 226068_at 
                 BF593625 
                 Hs.371720 
                 SYK 
               
               
                 223049_at 
                 AF246238 
                 Hs.444356 
                 GRB2 
               
               
                 203394_s_at 
                 BE973687 
                 Hs.250666 
                 HES1 
               
               
                 201465_s_at 
                 BC002646 
                 Hs.714791 
                 JUN 
               
               
                 202625_at 
                 AI356412 
                 Hs.699154 
                 LYN 
               
               
                 231856_at 
                 AB033070 
                 Hs.656215 
                 KIAA1244 
               
               
                 201841_s_at 
                 NM_001540 
                 Hs.520973 
                 HSPB1 
               
               
                 209154_at 
                 AF234997 
                 Hs.12956 
                 TAX1BP3 
               
               
                 210010_s_at 
                 U25147 
                 Hs.111024 
                 SLC25A1 
               
               
                 1554600_s_at 
                 BC033088 
                 Hs.594444 
                 LMNA 
               
               
                 204259_at 
                 NM_002423 
                 Hs.2256 
                 MMP7 
               
               
                 218804_at 
                 NM_018043 
                 Hs.503074 
                 ANO1 
               
               
                 208799_at 
                 BC004146 
                 Hs.422990 
                 PSMB5 
               
               
                 202626_s_at 
                 NM_002350 
                 Hs.699154 
                 LYN 
               
               
                 244023_at 
                 AW467357 
                 Hs.371720 
                 SYK 
               
               
                 226189_at 
                 BF513121 
                 Hs.592171 
                 ITGB8 
               
               
                 227817_at 
                 R51324 
                 Hs.460355 
                 PRKCB 
               
               
                 203411_s_at 
                 NM_005572 
                 Hs.594444 
                 LMNA 
               
               
                 212992_at 
                 AI935123 
                 Hs.441783 
                 AHNAK2 
               
               
                 211896_s_at 
                 AF138302 
                 Hs.706262 
                 DCN 
               
               
                 215464_s_at 
                 AK001327 
                 Hs.12956 
                 TAX1BP3 
               
               
                 215807_s_at 
                 AV693216 
                 Hs.476209 
                 PLXNB1 
               
               
                 1560225_at 
                 AI434253 
                 Hs.75110 
                 CNR1 
               
               
                 215075_s_at 
                 L29511 
                 Hs.444356 
                 GRB2 
               
               
                 36711_at 
                 AL021977 
                 Hs.517617 
                 MAFF 
               
               
                 210754_s_at 
                 M79321 
                 Hs.699154 
                 LYN 
               
               
                 209856_x_at 
                 U31089 
                 Hs.471156 
                 ABI2 
               
               
                 222920_s_at 
                 BG231515 
                 Hs.33187 
                 KIAA0748 
               
               
                 201903_at 
                 NM_003365 
                 Hs.119251 
                 UQCRC1 
               
               
                 242785_at 
                 BF663308 
                 Hs.656692 
                 FLJ42562 
               
               
                 221602_s_at 
                 AF057557 
                 Hs.58831 
                 FAIM3 
               
               
                 207238_s_at 
                 NM_002838 
                 Hs.654514 
                 PTPRC 
               
               
                 221571_at 
                 AI721219 
                 Hs.510528 
                 TRAF3 
               
               
                 213265_at 
                 AI570199 
                 Hs.601055 
                 PGA3 
               
               
                 235591_at 
                 R62424 
                 Hs.248160 
                 SSTR1 
               
               
                 205517_at 
                 AV700724 
                 Hs.243987 
                 GATA4 
               
               
                 209301_at 
                 M36532 
                 Hs.155097 
                 CA2 
               
               
                 206561_s_at 
                 NM_020299 
                 Hs.116724 
                 AKR1B10 
               
               
                 232352_at 
                 AK001022 
                 Hs.444677 
                 ISL2 
               
               
                 220421_at 
                 NM_024850 
                 Hs.189109 
                 BTNL8 
               
               
                 225330_at 
                 AL044092 
                 Hs.643120 
                 IGF1R 
               
               
                 214510_at 
                 NM_005293 
                 Hs.188859 
                 GPR20 
               
               
                 202949_s_at 
                 NM_001450 
                 Hs.443687 
                 FHL2 
               
               
                 206262_at 
                 NM_000669 
                 Hs.654537 
                 ADH1C 
               
               
                 203438_at 
                 AI435828 
                 Hs.233160 
                 STC2 
               
               
                 214133_at 
                 AI611214 
                   
                 LOC100133432 
               
               
                 226907_at 
                 N32557 
                 Hs.486798 
                 PPP1R14C 
               
               
                 209950_s_at 
                 BC004300 
                 Hs.103665 
                 VILL 
               
               
                 205009_at 
                 NM_003225 
                 Hs.162807 
                 TFF1 
               
               
                 214164_x_at 
                 BF752277 
                 Hs.210995 
                 CA12 
               
               
                 203627_at 
                 AI830698 
                 Hs.643120 
                 IGF1R 
               
               
                 207522_s_at 
                 NM_005173 
                 Hs.513870 
                 ATP2A3 
               
               
                 227156_at 
                 AK025872 
                 Hs.495984 
                 CASK 
               
               
                 227048_at 
                 AI990816 
                 Hs.270364 
                 LAMA1 
               
               
                 205343_at 
                 NM_001056 
                 Hs.436123 
                 SULT1C2 
               
               
                 214014_at 
                 W81196 
                 Hs.343380 
                 CDC42EP2 
               
               
                 236264_at 
                 BF511741 
                 Hs.28391 
                 LPHN3 
               
               
                 210735_s_at 
                 BC000278 
                 Hs.210995 
                 CA12 
               
               
                 205842_s_at 
                 AF001362 
                 Hs.656213 
                 JAK2 
               
               
                 213036_x_at 
                 Y15724 
                 Hs.513870 
                 ATP2A3 
               
               
                 207139_at 
                 NM_000704 
                 Hs.36992 
                 ATP4A 
               
               
                 208250_s_at 
                 NM_004406 
                 Hs.279611 
                 DMBT1 
               
               
                 230135_at 
                 AI822137 
               
               
                 1557545_s_at 
                 BF529886 
                 Hs.501114 
                 RNF165 
               
               
                 237466_s_at 
                 AW444502 
                 Hs.507991 
                 HHIP 
               
               
                 212816_s_at 
                 BE613178 
                 Hs.533013 
                 CBS 
               
               
                 204508_s_at 
                 BC001012 
                 Hs.210995 
                 CA12 
               
               
                 229160_at 
                 AI967987 
                 Hs.592221 
                 MUM1L1 
               
               
                 209875_s_at 
                 M83248 
                 Hs.313 
                 SPP1 
               
               
                 206242_at 
                 NM_003963 
                 Hs.184194 
                 TM4SF5 
               
               
                 230923_at 
                 AI824004 
                 Hs.655061 
                 FAM19A1 
               
               
                 1558796_a_at 
                 AL833240 
                 Hs.709829 
                 LOC728052 
               
               
                 203628_at 
                 H05812 
                 Hs.643120 
                 IGF1R 
               
               
                 223877_at 
                 AF329839 
                 Hs.153714 
                 C1QTNF7 
               
               
                 212713_at 
                 R72286 
                 Hs.296049 
                 MFAP4 
               
               
                 203131_at 
                 NM_006206 
                 Hs.74615 
                 PDGFRA 
               
               
                 217590_s_at 
                 AA502609 
                 Hs.137674 
                 TRPA1 
               
               
                 229400_at 
                 AW299531 
                 Hs.123070 
                 HOXD10 
               
               
                 203963_at 
                 NM_001218 
                 Hs.210995 
                 CA12 
               
               
                 218880_at 
                 N36408 
                 Hs.220971 
                 FOSL2 
               
               
                 225958_at 
                 AI554106 
                 Hs.305985 
                 PHC1 
               
               
                 210993_s_at 
                 U54826 
                 Hs.604588 
                 SMAD1 
               
               
                 227798_at 
                 AU146891 
                 Hs.604588 
                 SMAD1 
               
               
                 202514_at 
                 AW139131 
                 Hs.292549 
                 DLG1 
               
               
                 225144_at 
                 AI457436 
                 Hs.471119 
                 BMPR2 
               
               
                 203269_at 
                 NM_003580 
                 Hs.372000 
                 NSMAF 
               
               
                 1861_at 
                 U66879 
                 Hs.370254 
                 BAD 
               
               
                 211464_x_at 
                 U20537 
                 Hs.654616 
                 CASP6 
               
               
                 208865_at 
                 BG534245 
                 Hs.529862 
                 CSNK1A1 
               
               
                 201464_x_at 
                 BG491844 
                 Hs.714791 
                 JUN 
               
               
                 218338_at 
                 NM_004426 
                 Hs.305985 
                 PHC1 
               
               
                 210627_s_at 
                 BC002804 
                 Hs.516119 
                 GCS1 
               
               
                 202704_at 
                 AA675892 
                 Hs.709952 
                 TOB1 
               
               
                 202484_s_at 
                 AF072242 
                 Hs.25674 
                 MBD2 
               
               
                 209349_at 
                 U63139 
                 Hs.655835 
                 RAD50 
               
               
                 225262_at 
                 AI670862 
                 Hs.220971 
                 FOSL2 
               
               
                 203395_s_at 
                 NM_005524 
                 Hs.250666 
                 HES1 
               
               
                 209790_s_at 
                 BC000305 
                 Hs.654616 
                 CASP6 
               
               
                 201466_s_at 
                 NM_002228 
                 Hs.714791 
                 JUN 
               
               
                 210512_s_at 
                 AF022375 
                 Hs.73793 
                 VEGFA 
               
               
                 209160_at 
                 AB018580 
                 Hs.78183 
                 AKR1C3 
               
               
                 202351_at 
                 AI093579 
                 Hs.436873 
                 ITGAV 
               
               
                 202417_at 
                 NM_012289 
                 Hs.465870 
                 KEAP1 
               
               
                 233849_s_at 
                 AK023014 
                 Hs.592313 
                 ARHGAP5 
               
               
                 203581_at 
                 BC002438 
                 Hs.296169 
                 RAB4A 
               
               
                 215356_at 
                 AK023134 
                 Hs.646351 
                 TDRD12 
               
               
                 226852_at 
                 AB033092 
                 Hs.435413 
                 MTA3 
               
               
                 208891_at 
                 BC003143 
                 Hs.298654 
                 DUSP6 
               
               
                 214119_s_at 
                 AI936769 
                 Hs.471933 
                 FKBP1A 
               
               
                 203132_at 
                 NM_000321 
                 Hs.408528 
                 RB1 
               
               
                 213980_s_at 
                 AA053830 
                 Hs.208597 
                 CTBP1 
               
               
                 217936_at 
                 AW044631 
                 Hs.592313 
                 ARHGAP5 
               
               
                 225985_at 
                 AI935917 
                 Hs.43322 
                 PRKAA1 
               
               
                 1552648_a_at 
                 NM_003844 
                 Hs.591834 
                 TNFRSF10A 
               
               
                 212741_at 
                 AA923354 
                 Hs.183109 
                 MAOA 
               
               
                 208711_s_at 
                 BC000076 
                 Hs.523852 
                 CCND1 
               
               
                 232149_s_at 
                 BF056507 
                 Hs.372000 
                 NSMAF 
               
               
                 1557417_s_at 
                 AA844689 
                 Hs.442339 
                 RSPH10B 
               
               
                 1556194_a_at 
                 BC042959 
               
               
                 225757_s_at 
                 AU147564 
                 Hs.301478 
                 CLMN 
               
               
                 210896_s_at 
                 AF306765 
                 Hs.622998 
                 ASPH 
               
               
                 202935_s_at 
                 AI382146 
                 Hs.707993 
                 SOX9 
               
               
                 226048_at 
                 N92719 
                 Hs.138211 
                 MAPK8 
               
               
                 213724_s_at 
                 AI870615 
                 Hs.256667 
                 PDK2 
               
               
                 228670_at 
                 BF197089 
                 Hs.508835 
                 TEP1 
               
               
                 214259_s_at 
                 AI144075 
                 Hs.571886 
                 AKR7A2 
               
               
                 208724_s_at 
                 BC000905 
                 Hs.310645 
                 RAB1A 
               
               
                 203673_at 
                 NM_003235 
                 Hs.654591 
                 TG 
               
               
                 214977_at 
                 AK023852 
               
               
                 210055_at 
                 BE045816 
                 Hs.160411 
                 TSHR 
               
               
                 210342_s_at 
                 M17755 
                 Hs.467554 
                 TPO 
               
               
                 215443_at 
                 BE740743 
                 Hs.160411 
                 TSHR 
               
               
                 231070_at 
                 BF431199 
                 Hs.310225 
                 IYD 
               
               
                 228715_at 
                 AV725825 
                 Hs.21417 
                 ZCCHC12 
               
               
                 213482_at 
                 BF593175 
                 Hs.476284 
                 DOCK3 
               
               
                 213228_at 
                 AK023913 
                 Hs.584830 
                 PDE8B 
               
               
                 207144_s_at 
                 NM_004143 
                 Hs.40403 
                 CITED1 
               
               
                 239006_at 
                 AI758950 
                 Hs.354013 
                 SLC26A7 
               
               
                 229782_at 
                 BE468066 
                 Hs.652568 
                 RMST 
               
               
                 207695_s_at 
                 NM_001555 
                 Hs.22111 
                 IGSF1 
               
               
                 1554789_a_at 
                 AB085825 
                 Hs.584830 
                 PDE8B 
               
               
                 222325_at 
                 AW974812 
               
               
                 242344_at 
                 AA772920 
                 Hs.303527 
                 GABRB2 
               
               
                 1557136_at 
                 BG059633 
                 Hs.674423 
                 ATP13A4 
               
               
                 219836_at 
                 NM_024508 
                 Hs.136912 
                 ZBED2 
               
               
                 235460_at 
                 AW149670 
                 Hs.708268 
                 SNX22 
               
               
                 209824_s_at 
                 AB000812 
                 Hs.65734 
                 ARNTL 
               
               
                 227238_at 
                 W93847 
                 Hs.407152 
                 MUC15 
               
               
                 210971_s_at 
                 AB000815 
                 Hs.65734 
                 ARNTL 
               
               
                 238047_at 
                 AA405456 
                 Hs.22905 
                 RP13-102H20.1 
               
               
                 219529_at 
                 NM_004669 
                 Hs.64746 
                 CLIC3 
               
               
                 227241_at 
                 R79759 
                 Hs.407152 
                 MUC15 
               
               
                 235251_at 
                 AW292765 
               
               
                 221795_at 
                 AI346341 
                 Hs.494312 
                 NTRK2 
               
               
                 214680_at 
                 BF674712 
                 Hs.494312 
                 NTRK2 
               
               
                 1557122_s_at 
                 BC036592 
                 Hs.303527 
                 GABRB2 
               
               
                 206457_s_at 
                 NM_000792 
                 Hs.251415 
                 DIO1 
               
               
                 219949_at 
                 NM_024512 
                 Hs.657345 
                 LRRC2 
               
               
                 1565936_a_at 
                 T24091 
                 Hs.504908 
                 LMO3 
               
               
                 202219_at 
                 NM_005629 
                 Hs.540696 
                 SLC6A8 
               
               
                 200832_s_at 
                 AB032261 
                 Hs.558396 
                 SCD 
               
               
                 222294_s_at 
                 AW971415 
                 Hs.654978 
                 RAB27A 
               
               
                 228984_at 
                 AB037815 
                 Hs.502982 
                 KIAA1394 
               
               
                 221796_at 
                 AA707199 
                 Hs.494312 
                 NTRK2 
               
               
                 210621_s_at 
                 M23612 
                 Hs.664080 
                 RASA1 
               
               
                 205728_at 
                 AL022718 
               
               
                 1555404_a_at 
                 BC029819 
                 Hs.356664 
                 DUOXA1 
               
               
                 235766_x_at 
                 AA743462 
                 Hs.654978 
                 RAB27A 
               
               
                 221539_at 
                 AB044548 
                 Hs.411641 
                 EIF4EBP1 
               
               
                 223623_at 
                 AF325503 
                 Hs.43125 
                 C2orf40 
               
               
                 223572_at 
                 AB042554 
                 Hs.476041 
                 HHATL 
               
               
                 209292_at 
                 AL022726 
                 Hs.519601 
                 ID4 
               
               
                 228173_at 
                 AA810695 
                 Hs.125898 
                 GNAS 
               
               
                 205954_at 
                 NM_006917 
                 Hs.26550 
                 RXRG 
               
               
                 201587_s_at 
                 NM_001569 
                 Hs.522819 
                 IRAK1 
               
               
                 219597_s_at 
                 NM_017434 
                 Hs.272813 
                 DUOX1 
               
               
                 209515_s_at 
                 U38654 
                 Hs.654978 
                 RAB27A 
               
               
                 231240_at 
                 AI038059 
                 Hs.202354 
                 DIO2 
               
               
                 230585_at 
                 AI632692 
               
               
                 219727_at 
                 NM_014080 
                 Hs.71377 
                 DUOX2 
               
               
                 203413_at 
                 NM_006159 
                 Hs.505326 
                 NELL2 
               
               
                 213106_at 
                 AI769688 
                 Hs.435052 
                 ATP8A1 
               
               
                 232424_at 
                 AI623202 
                 Hs.99500 
                 PRDM16 
               
               
                 208892_s_at 
                 BC003143 
                 Hs.298654 
                 DUSP6 
               
               
                 209683_at 
                 AA243659 
                 Hs.467769 
                 FAM49A 
               
               
                 232478_at 
                 AU146021 
               
               
                 235977_at 
                 BF433341 
                 Hs.21380 
                 LONRF2 
               
               
                 225911_at 
                 AL138410 
                 Hs.518921 
                 NPNT 
               
               
                 230276_at 
                 AI934342 
                 Hs.467769 
                 FAM49A 
               
               
                 230290_at 
                 BE674338 
                 Hs.12923 
                 SCUBE3 
               
               
                 225433_at 
                 AU144104 
                 Hs.592334 
                 GTF2A1 
               
               
                 215240_at 
                 AI189839 
                 Hs.218040 
                 ITGB3 
               
               
                 37986_at 
                 M60459 
                 Hs.631624 
                 EPOR 
               
               
                 203699_s_at 
                 U53506 
                 Hs.202354 
                 DIO2 
               
               
                 202788_at 
                 NM_004635 
                 Hs.234521 
                 MAPKAPK3 
               
               
                 205721_at 
                 U97145 
                 Hs.441202 
                 GFRA2 
               
               
                 228955_at 
                 AL041761 
               
               
                 225996_at 
                 AV709727 
                 Hs.21380 
                 LONRF2 
               
               
                 231348_s_at 
                 BF508869 
                 Hs.504908 
                 LMO3 
               
               
                 225380_at 
                 BF528878 
                 Hs.408542 
                 LOC91461 
               
               
                 202787_s_at 
                 U43784 
                 Hs.234521 
                 MAPKAPK3 
               
               
                 222901_s_at 
                 AF153815 
                 Hs.463985 
                 KCNJ16 
               
               
                 227449_at 
                 AI799018 
                 Hs.371218 
                 EPHA4 
               
               
                 222830_at 
                 BE566136 
                 Hs.418493 
                 GRHL1 
               
               
                 208078_s_at 
                 NM_030751 
                 Hs.124503 
                 ZEB1 
               
               
                 223278_at 
                 M86849 
                 Hs.524894 
                 GJB2 
               
               
                 204225_at 
                 NM_006037 
                 Hs.20516 
                 HDAC4 
               
               
                 220751_s_at 
                 NM_016348 
                 Hs.519694 
                 C5orf4 
               
               
                 212224_at 
                 NM_000689 
                 Hs.76392 
                 ALDH1A1 
               
               
                 212983_at 
                 NM_005343 
                 Hs.37003 
                 HRAS 
               
               
                 35846_at 
                 M24899 
                 Hs.724 
                 THRA 
               
               
                 201116_s_at 
                 AI922855 
                 Hs.712551 
                 CPE 
               
               
                 205220_at 
                 NM_006018 
                 Hs.458425 
                 GPR109B 
               
               
                 200863_s_at 
                 AI215102 
                 Hs.321541 
                 RAB11A 
               
               
                 204420_at 
                 BG251266 
                 Hs.283565 
                 FOSL1 
               
               
                 208760_at 
                 AL031714 
                 Hs.302903 
                 UBE2I 
               
               
                 203625_x_at 
                 BG105365 
                 Hs.23348 
                 SKP2 
               
               
                 236523_at 
                 BF435831 
                 Hs.480371 
                 LOC285556 
               
               
                 227705_at 
                 BF591534 
                 Hs.21861 
                 TCEAL7 
               
               
                 209904_at 
                 AF020769 
                 Hs.118845 
                 TNNC1 
               
               
                 235004_at 
                 AI677701 
                 Hs.519904 
                 RBM24 
               
               
                 207302_at 
                 NM_000231 
                 Hs.37167 
                 SGCG 
               
               
                 233364_s_at 
                 AK021804 
               
               
                 206717_at 
                 NM_002472 
                 Hs.700484 
                 MYH8 
               
               
                 34471_at 
                 M36769 
                 Hs.700484 
                 MYH8 
               
               
                 219186_at 
                 NM_020224 
                 Hs.591384 
                 ZBTB7A 
               
               
                 219728_at 
                 NM_006790 
                 Hs.84665 
                 MYOT 
               
               
                 217057_s_at 
                 AF107846 
                 Hs.125898 
                 GNAS 
               
               
                 220359_s_at 
                 NM_016300 
                 Hs.475902 
                 ARPP-21 
               
               
                 243346_at 
                 BF109621 
                 Hs.350621 
                 LMOD3 
               
               
                 200604_s_at 
                 M18468 
                 Hs.280342 
                 PRKAR1A 
               
               
                 232010_at 
                 AA129444 
                 Hs.591707 
                 FSTL5 
               
               
                 233949_s_at 
                 AI160292 
                 Hs.414122 
                 MYH7B 
               
               
                 217404_s_at 
                 X16468 
                 Hs.408182 
                 COL2A1 
               
               
                 204776_at 
                 NM_003248 
                 Hs.211426 
                 THBS4 
               
               
                 213492_at 
                 X06268 
                 Hs.408182 
                 COL2A1 
               
               
                 242856_at 
                 AI291804 
               
               
                 231935_at 
                 AL133109 
                 Hs.475902 
                 ARPP-21 
               
               
                 212092_at 
                 BE858180 
                 Hs.147492 
                 PEG10 
               
               
                 235355_at 
                 AL037998 
               
               
                 206394_at 
                 NM_004533 
                 Hs.85937 
                 MYBPC2 
               
               
                 206373_at 
                 NM_003412 
                 Hs.598590 
                 ZIC1 
               
               
                 202688_at 
                 NM_003810 
                 Hs.478275 
                 TNFSF10 
               
               
                 205817_at 
                 NM_005982 
                 Hs.714419 
                 SIX1 
               
               
                 205163_at 
                 NM_013292 
                 Hs.50889 
                 MYLPF 
               
               
                 212688_at 
                 BC003393 
                 Hs.239818 
                 PIK3CB 
               
               
                 201349_at 
                 NM_004252 
                 Hs.711846 
                 SLC9A3R1 
               
               
                 235077_at 
                 BF956762 
                 Hs.525589 
                 MEG3 
               
               
                 211537_x_at 
                 AF218074 
                 Hs.714773 
                 MAP3K7 
               
               
                 207148_x_at 
                 NM_016599 
                 Hs.381047 
                 MYOZ2 
               
               
                 218974_at 
                 NM_018013 
                 Hs.445244 
                 SOBP 
               
               
                 205940_at 
                 NM_002470 
                 Hs.440895 
                 MYH3 
               
               
                 205388_at 
                 NM_003279 
                 Hs.182421 
                 TNNC2 
               
               
                 219772_s_at 
                 NM_014332 
                 Hs.86492 
                 SMPX 
               
               
                 206117_at 
                 NM_000366 
                 Hs.133892 
                 TPM1 
               
               
                 226913_s_at 
                 BF527050 
                 Hs.243678 
                 SOX8 
               
               
                 229374_at 
                 AI758962 
                 Hs.371218 
                 EPHA4 
               
               
                 205676_at 
                 NM_000785 
                 Hs.524528 
                 CYP27B1 
               
               
                 219894_at 
                 NM_019066 
                 Hs.141496 
                 MAGEL2 
               
               
                 211536_x_at 
                 AB009358 
                 Hs.714773 
                 MAP3K7 
               
               
                 205736_at 
                 NM_000290 
                 Hs.632642 
                 PGAM2 
               
               
                 226554_at 
                 AW445134 
                 Hs.591384 
                 ZBTB7A 
               
               
                 235927_at 
                 BE350122 
                 Hs.370770 
                 XPO1 
               
               
                 212558_at 
                 BF508662 
                 Hs.436944 
                 SPRY1 
               
               
                 226856_at 
                 BF793701 
                 Hs.556077 
                 MUSTN1 
               
               
                 211793_s_at 
                 AF260261 
                 Hs.471156 
                 ABI2 
               
               
                 239537_at 
                 AW589904 
                 Hs.302341 
                 ST8SIA2 
               
               
                 205693_at 
                 NM_006757 
                 Hs.73454 
                 TNNT3 
               
               
                 222919_at 
                 AA192306 
                 Hs.654601 
                 TRDN 
               
               
                 209190_s_at 
                 AF051782 
                 Hs.529451 
                 DIAPH1 
               
               
                 205577_at 
                 NM_005609 
                 Hs.154084 
                 PYGM 
               
               
                 220260_at 
                 NM_018317 
                 Hs.479403 
                 TBC1D19 
               
               
                 232955_at 
                 AU144397 
                 Hs.611431 
                 FLJ41170 
               
               
                 230915_at 
                 AI741629 
                 Hs.61684 
                 DHRS7C 
               
               
                 231721_at 
                 AF356518 
                 Hs.150718 
                 JAM3 
               
               
                 207293_s_at 
                 U16957 
                 Hs.405348 
                 AGTR2 
               
               
                 219804_at 
                 NM_024875 
                 Hs.645273 
                 SYNPO2L 
               
               
                 210794_s_at 
                 AF119863 
                 Hs.525589 
                 MEG3 
               
               
                 244839_at 
                 AW975934 
                 Hs.134602 
                 TTN 
               
               
                 206657_s_at 
                 NM_002478 
                 Hs.181768 
                 MYOD1 
               
               
                 227823_at 
                 BE348679 
                 Hs.512180 
                 RGAG4 
               
               
                 212094_at 
                 AL582836 
                 Hs.147492 
                 PEG10 
               
               
                 202687_s_at 
                 U57059 
                 Hs.478275 
                 TNFSF10 
               
               
                 205902_at 
                 AJ251016 
                 Hs.490765 
                 KCNN3 
               
               
                 1559965_at 
                 BC037827 
               
               
                 1729_at 
                 L41690 
                 Hs.460996 
                 TRADD 
               
               
                 207066_at 
                 NM_002152 
                 Hs.436885 
                 HRC 
               
               
                 218824_at 
                 NM_018215 
                 Hs.8395 
                 PNMAL1 
               
               
                 205900_at 
                 NM_006121 
                 Hs.80828 
                 KRT1 
               
               
                 207324_s_at 
                 NM_004948 
                 Hs.567260 
                 DSC1 
               
               
                 206642_at 
                 NM_001942 
                 Hs.2633 
                 DSG1 
               
               
                 220664_at 
                 NM_006518 
                 Hs.2421 
                 SPRR2C 
               
               
                 207356_at 
                 NM_004942 
                 Hs.105924 
                 DEFB4 
               
               
                 205724_at 
                 NM_000299 
                 Hs.497350 
                 PKP1 
               
               
                 215704_at 
                 AL356504 
                 Hs.654510 
                 FLG 
               
               
                 237732_at 
                 AI432195 
               
               
                 41469_at 
                 L10343 
                 Hs.112341 
                 PI3 
               
               
                 230193_at 
                 AI479075 
                 Hs.709837 
                 WDR66 
               
               
                 203691_at 
                 NM_002638 
                 Hs.112341 
                 PI3 
               
               
                 1553081_at 
                 NM_080869 
                 Hs.352180 
                 WFDC12 
               
               
                 239853_at 
                 AI279514 
                 Hs.298079 
                 KLC3 
               
               
                 231033_at 
                 AI819863 
               
               
                 241813_at 
                 BG252318 
                 Hs.405610 
                 MBD1 
               
               
                 205109_s_at 
                 NM_015320 
                 Hs.469935 
                 ARHGEF4 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 200 genes used in conjunction with clinical variables to predict 
               
               
                 breast cancer recurrence risk status. P-value is testing the 
               
               
                 hypothesis if the expression data is predictive of survival 
               
               
                 over and above the clinical variable covariates. 
               
            
           
           
               
               
               
               
            
               
                 Affymetrix 
                 Gene 
                   
                 Entrez 
               
               
                 Probe ID 
                 symbol 
                 Genbank 
                 Gene ID 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 209856_x_at 
                 ABI2 
                 U31089 
                 10152 
               
               
                 202502_at 
                 ACADM 
                 NM_000016 
                 34 
               
               
                 210838_s_at 
                 ACVRL1 
                 L17075 
                 94 
               
               
                 205746_s_at 
                 ADAM17 
                 U86755 
                 6868 
               
               
                 206807_s_at 
                 ADD2 
                 NM_017482 
                 119 
               
               
                 212224_at 
                 ALDH1A1 
                 NM_000689 
                 216 
               
               
                 204174_at 
                 ALOX5AP 
                 NM_001629 
                 241 
               
               
                 201302_at 
                 ANXA4 
                 NM_001153 
                 307 
               
               
                 205083_at 
                 AOX1 
                 NM_001159 
                 316 
               
               
                 208074_s_at 
                 AP2S1 
                 NM_021575 
                 1175 
               
               
                 202120_x_at 
                 AP2S1 
                 NM_004069 
                 1175 
               
               
                 211047_x_at 
                 AP2S1 
                 BC006337 
                 1175 
               
               
                 203526_s_at 
                 APC 
                 M74088 
                 324 
               
               
                 214995_s_at 
                 APOBEC3F 
                 BF508948 
                 200316 /// 
               
               
                   
                   
                   
                 60489 
               
               
                 213702_x_at 
                 ASAH1 
                 AI934569 
                 427 
               
               
                 210980_s_at 
                 ASAH1 
                 U47674 
                 427 
               
               
                 218659_at 
                 ASXL2 
                 NM_018263 
                 55252 
               
               
                 212672_at 
                 ATM 
                 U82828 
                 472 
               
               
                 217014_s_at 
                 AZGP1 
                 AC004522 
                 563 /// 
               
               
                   
                   
                   
                 646282 
               
               
                 209311_at 
                 BCL2L2 
                 D87461 
                 599 
               
               
                 209974_s_at 
                 BUB3 
                 AF047473 
                 9184 
               
               
                 218614_at 
                 C12orf35 
                 NM_018169 
                 55196 
               
               
                 221434_s_at 
                 C14orf156 
                 NM_031210 
                 81892 
               
               
                 203830_at 
                 C17orf75 
                 NM_022344 
                 64149 
               
               
                 209006_s_at 
                 C1orf63 
                 AF247168 
                 57035 
               
               
                 219288_at 
                 C3orf14 
                 NM_020685 
                 57415 
               
               
                 220324_at 
                 C6orf155 
                 NM_024882 
                 79940 
               
               
                 219223_at 
                 C9orf7 
                 NM_017586 
                 11094 
               
               
                 207243_s_at 
                 CALM2 
                 NM_001743 
                 805 
               
               
                 214845_s_at 
                 CALU 
                 AF257659 
                 813 
               
               
                 200756_x_at 
                 CALU 
                 U67280 
                 813 
               
               
                 211922_s_at 
                 CAT 
                 AY028632 
                 847 
               
               
                 214710_s_at 
                 CCNB1 
                 BE407516 
                 891 
               
               
                 215784_at 
                 CD1E 
                 AA309511 
                 913 
               
               
                 211574_s_at 
                 CD46 
                 D84105 
                 4179 
               
               
                 207319_s_at 
                 CDC2L5 
                 NM_003718 
                 8621 
               
               
                 218592_s_at 
                 CECR5 
                 NM_017829 
                 27440 
               
               
                 40020_at 
                 CELSR3 
                 AB011536 
                 1951 
               
               
                 209508_x_at 
                 CFLAR 
                 AF005774 
                 8837 
               
               
                 210564_x_at 
                 CFLAR 
                 AF009619 
                 8837 
               
               
                 203975_s_at 
                 CHAF1A 
                 BF000239 
                 10036 
               
               
                 204170_s_at 
                 CKS2 
                 NM_001827 
                 1164 
               
               
                 64486_at 
                 CORO1B 
                 AI341234 
                 57175 
               
               
                 205538_at 
                 CORO2A 
                 NM_003389 
                 7464 
               
               
                 210687_at 
                 CPT1A 
                 BC000185 
                 1374 
               
               
                 214513_s_at 
                 CREB1 
                 M34356 
                 1385 
               
               
                 204313_s_at 
                 CREB1 
                 AA161486 
                 1385 
               
               
                 202978_s_at 
                 CREBZF 
                 AW204564 
                 58487 
               
               
                 201200_at 
                 CREG1 
                 NM_003851 
                 8804 
               
               
                 218924_s_at 
                 CTBS 
                 NM_004388 
                 1486 
               
               
                 205898_at 
                 CX3CR1 
                 U20350 
                 1524 
               
               
                 219969_at 
                 CXorf15 
                 NM_018360 
                 55787 
               
               
                 205417_s_at 
                 DAG1 
                 NM_004393 
                 1605 
               
               
                 201571_s_at 
                 DCTD 
                 AI656493 
                 1635 
               
               
                 219328_at 
                 DDX31 
                 NM_022779 
                 64794 
               
               
                 221509_at 
                 DENR 
                 AB014731 
                 8562 
               
               
                 202865_at 
                 DNAJB12 
                 AI695173 
                 54788 
               
               
                 209059_s_at 
                 EDF1 
                 AB002282 
                 8721 
               
               
                 213614_x_at 
                 EEF1A1 
                 BE786672 
                 1915 
               
               
                 222314_x_at 
                 EGO 
                 AW970881 
               
               
                 208688_x_at 
                 EIF3B 
                 U78525 
                 8662 
               
               
                 200005_at 
                 EIF3D 
                 NM_003753 
                 8664 
               
               
                 201726_at 
                 ELAVL1 
                 BC003376 
                 1994 
               
               
                 212087_s_at 
                 ERAL1 
                 AL562733 
                 26284 
               
               
                 204817_at 
                 ESPL1 
                 NM_012291 
                 9700 
               
               
                 213007_at 
                 FANCI 
                 W74442 
                 55215 
               
               
                 213008_at 
                 FANCI 
                 BG403615 
                 55215 
               
               
                 209456_s_at 
                 FBXW11 
                 AB033281 
                 23291 
               
               
                 204767_s_at 
                 FEN1 
                 BC000323 
                 2237 
               
               
                 208228_s_at 
                 FGFR2 
                 M87771 
                 2263 
               
               
                 203638_s_at 
                 FGFR2 
                 NM_022969 
                 2263 
               
               
                 204236_at 
                 FLI1 
                 NM_002017 
                 2313 
               
               
                 202838_at 
                 FUCA1 
                 NM_000147 
                 2517 
               
               
                 217370_x_at 
                 FUS 
                 S75762 
                 2521 
               
               
                 207112_s_at 
                 GAB1 
                 NM_002039 
                 2549 
               
               
                 203725_at 
                 GADD45A 
                 NM_001924 
                 1647 
               
               
                 210872_x_at 
                 GAS7 
                 BC001152 
                 8522 
               
               
                 208503_s_at 
                 GATAD1 
                 NM_021167 
                 57798 
               
               
                 219777_at 
                 GIMAP6 
                 NM_024711 
                 474344 
               
               
                 207387_s_at 
                 GK 
                 NM_000167 
                 2710 
               
               
                 212241_at 
                 GRINL1A 
                 AI632774 
                 145781 /// 
               
               
                   
                   
                   
                 339970 /// 
               
               
                   
                   
                   
                 81488 
               
               
                 210981_s_at 
                 GRK6 
                 AF040751 
                 2870 
               
               
                 205436_s_at 
                 H2AFX 
                 NM_002105 
                 3014 
               
               
                 221976_s_at 
                 HDGFRP3 
                 AW207448 
                 50810 
               
               
                 206313_at 
                 HLA-DOA 
                 NM_002119 
                 3111 
               
               
                 203744_at 
                 HMGB3 
                 NM_005342 
                 3149 
               
               
                 201277_s_at 
                 HNRNPAB 
                 NM_004499 
                 3182 
               
               
                 213619_at 
                 HNRNPH1 
                 AV753392 
                 3187 
               
               
                 204785_x_at 
                 IFNAR2 
                 NM_000874 
                 3455 
               
               
                 212196_at 
                 IL6ST 
                 AW242916 
                 3572 
               
               
                 208930_s_at 
                 ILF3 
                 BG032366 
                 3609 
               
               
                 217732_s_at 
                 ITM2B 
                 AF092128 
                 9445 
               
               
                 214098_at 
                 KIAA1107 
                 AB029030 
                 23285 
               
               
                 218755_at 
                 KIF20A 
                 NM_005733 
                 10112 
               
               
                 209680_s_at 
                 KIFC1 
                 BC000712 
                 3833 
               
               
                 213507_s_at 
                 KPNB1 
                 BG249565 
                 3837 
               
               
                 34031_i_at 
                 KRIT1 
                 U90269 
                 889 
               
               
                 205269_at 
                 LCP2 
                 AI123251 
                 3937 
               
               
                 203713_s_at 
                 LLGL2 
                 NM_004524 
                 3993 
               
               
                 203276_at 
                 LMNB1 
                 NM_005573 
                 4001 
               
               
                 201383_s_at 
                 LOC100133166 
                 AL044170 
                 4077 /// 
               
               
                   
                   
                   
                 727732 
               
               
                 208633_s_at 
                 MACF1 
                 W61052 
                 23499 
               
               
                 203266_s_at 
                 MAP2K4 
                 NM_003010 
                 6416 
               
               
                 207292_s_at 
                 MAPK7 
                 NM_002749 
                 5598 
               
               
                 208403_x_at 
                 MAX 
                 NM_002382 
                 4149 
               
               
                 212023_s_at 
                 MKI67 
                 AU147044 
                 4288 
               
               
                 220526_s_at 
                 MRPL20 
                 NM_017971 
                 55052 
               
               
                 212093_s_at 
                 MTUS1 
                 AI695017 
                 57509 
               
               
                 214753_at 
                 N4BP2L2 
                 AW084068 
                 10443 
               
               
                 221242_at 
                   
                 NM_025051 
               
               
                 217591_at 
                   
                 BF725121 
                 6498 
               
               
                 205732_s_at 
                 NCOA2 
                 NM_006540 
                 10499 
               
               
                 219961_s_at 
                 NCRNA00153 
                 NM_018474 
                 55857 
               
               
                 203606_at 
                 NDUFS6 
                 NM_004553 
                 4726 
               
               
                 218318_s_at 
                 NLK 
                 NM_016231 
                 51701 
               
               
                 209750_at 
                 NR1D2 
                 N32859 
                 9975 
               
               
                 211671_s_at 
                 NR3C1 
                 U01351 
                 2908 
               
               
                 201865_x_at 
                 NR3C1 
                 AI432196 
                 2908 
               
               
                 212181_s_at 
                 NUDT4 
                 AF191654 
                 11163 
               
               
                 218039_at 
                 NUSAP1 
                 NM_016359 
                 51203 
               
               
                 219582_at 
                 OGFRL1 
                 NM_024576 
                 79627 
               
               
                 205233_s_at 
                 PAFAH2 
                 NM_000437 
                 5051 
               
               
                 209431_s_at 
                 PATZ1 
                 AF254083 
                 23598 
               
               
                 211807_x_at 
                 PCDHGB5 
                 AF152521 
                 56101 
               
               
                 212094_at 
                 PEG10 
                 AL582836 
                 23089 
               
               
                 215832_x_at 
                 PICALM 
                 AV722190 
                 8301 
               
               
                 203134_at 
                 PICALM 
                 NM_007166 
                 8301 
               
               
                 201115_at 
                 POLD2 
                 NM_006230 
                 5425 
               
               
                 217806_s_at 
                 POLDIP2 
                 NM_015584 
                 26073 
               
               
                 209302_at 
                 POLR2H 
                 U37689 
                 5437 
               
               
                 218009_s_at 
                 PRC1 
                 NM_003981 
                 9055 
               
               
                 201494_at 
                 PRCP 
                 NM_005040 
                 5547 
               
               
                 202545_at 
                 PRKCD 
                 NM_006254 
                 5580 
               
               
                 206445_s_at 
                 PRMT1 
                 NM_001536 
                 3276 
               
               
                 211921_x_at 
                 PTMA 
                 AF348514 
                 5757 
               
               
                 200772_x_at 
                 PTMA 
                 BF686442 
                 5757 
               
               
                 208549_x_at 
                 PTMAP7 
                 NM_016171 
                 441454 /// 
               
               
                   
                   
                   
                 442347 /// 
               
               
                   
                   
                   
                 442727 
               
               
                 207419_s_at 
                 RAC2 
                 NM_002872 
                 5880 
               
               
                 222077_s_at 
                 RACGAP1 
                 AU153848 
                 29127 
               
               
                 220338_at 
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