Patent Publication Number: US-2003235819-A1

Title: Mutations in the BRCA1 gene

Description:
FIELD OF THE INVENTION  
       [0001] This invention relates to the cancer suppressor gene BRCA1. More specifically, this invention detects germline mutations of the BRCA1 gene that are associated with breast and ovarian cancer, and somatic cell mutations of the BRCA1 gene indicating the nature of the cancer. Methods and reagents for detecting the presence of these mutations are included.  
       COPYRIGHT NOTICE  
       [0002] A portion of the disclosure of this patent document contains material which is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure as it appears in the U.S. Patent and Trademark Office patent file or records, but otherwise reserves all copyright rights whatsoever.  
       BACKGROUND OF THE INVENTION  
       [0003] BRCA1 is a putative tumor suppressor gene located on chromosome 17. Mutations in the BRCA1 gene are thought to account for roughly 45% of inherited breast cancer and 80-90% of families with increased risk of early onset breast and ovarian cancer (Easton, 1993, et al.,  American Journal of Human Genetics  52; 678-701). A compilation of the known BRCA1 mutations may be found at the Breast Cancer Information Core world wide web site at http:/Hwww.nhgri.nih.gov/Intramural_research/Lab_transfer/Bic/(BIC) (Friend, S. et al., 1995,  Nature Genetics  11: 238). The BRCA1 gene is approximately 100,000 base pairs of genomic DNA encoding the 1836 amino acid BRCA1 protein. The sequence is divided into 24 separate exons. Exons 1 and 4 are noncoding, in that they are not part of the final functional BRCA1 protein product. Each exon consists of 200-400 bp, except for exon 11 which contains about 3600 bp (Weber, B., Science &amp; Medicine (1996). A consensus sequence for the coding region of the human BRCA1 gene, referred to herein as BRCA1 (omi1), was first disclosed in application Ser. No. 08/598,591 (as SEQ ID NO:1, therein), herein incorporated by reference.  
       [0004] Accuracy in detecting mutations in BRCA1 is extremely important, particularly in clinical settings. Direct end-to-end sequencing of the gene potentially provides the most reliable results, given that an accurate reference sequence is available. However, direct sequencing is a cumbersome technique. Detection of one of many known or unknown mutations is further complicated when the gene is large and/or has a complex structure. The human BRCA1 gene, for example, is approximately 100,000 base pairs long and contains 24 exons (Weber, B., Science and Medicine, Scientific American January-February 1996, 12-21). Furthermore, in order to be practical and available to the general population, mutation detection methods must be efficient enough to accommodate a large number of different samples.  
       [0005] A number of techniques that are more rapid but less comprehensive than direct sequencing have been developed for detecting nucleotide sequence variations. These techniques may be used to detect differences between normal and mutant nucleotide sequences. DNA sequence-based allelic discrimination methods include: (1) allele-specific hybridization techniques, which effect detection under high stringent hybridization conditions; (2) single strand conformation polymorphism analysis and heteroduplex analysis which exploit differences in secondary structure of nucleic acid molecules; (3) denaturing gradient gel electrophoresis and constant denaturing gel electrophoresis which detect different alleles based on differences in melting behavior of nucleic acid molecules; (4) restriction enzyme cleavage, which discriminates between alleles based on the presence of absence of corresponding restriction recognition sequences; and (5) chemical or nuclease cleavage which detect base mismatch loci. Other techniques, such as the protein truncation test (Hogervorst F. B., et al., Nat. Genet. June 1995; 10(2):208-212), detect changes in the protein transcripts. For a summary of such techniques, see Marajver &amp; Petty, 1996, Clinics in Lab. Med. 16: 139-167, especially Table 5 at p. 152.  
       [0006] One limitation of all these techniques is that sequence variations are often of unknown clinical significance. Since the triplet code is degenerate, many genetic variants do not alter the amino acid sequence of the resultant protein. Even those sequence alterations that do result in amino acid changes may not have a significant impact on protein function. For example, some amino acid changes will substitute functionally similar amino acids (conservative substitutions) such as one small neutrally charged amino acid for another. Further, some regions of a protein molecule may not be important for protein function. In those regions of the molecule, even large changes the amino acid sequence may be possible. Thus, genetic variants as a whole are often of unknown clinical significance.  
       [0007] If an altered sequence in the coding region of a gene associated with a condition such as cancer is found however, it is important to determine the clinical significance of the variant sequence. Knowing the significance of the sequence variation can be an invaluable tool in determining an appropriate treatment or monitoring regimen. For example, if an individual carries a mutation that interferes with protein function, it may be possible to provide the individual with increased expression of the gene through gene transfer therapy. It has been demonstrated that the gene transfer of the BRCA1 coding sequence into human cancer cells inhibits their growth and reduces tumorigenesis in nude mice. The BRCA1 protein product appears to be a secreted tumor growth inhibitor, making BRCA1 an ideal gene for gene therapy studies. Transduction of only a moderate percentage of tumor cells apparently produces enough growth inhibitor to inhibit all tumor cells. Arteaga, C. L., and J. T. Holt Cancer Research 56: 1098-1103 (1996); Holt, J. T. et al., Nature Genetics 12: 298-302 (1996). The observation of Holt et al. that the BRCA1 growth inhibitor is a secreted protein, also suggests the possibility of tumor suppression by injecting the growth irhibitor into the area of the tumor.  
       [0008] Efforts have independently focused on increasing the efficiency of DNA sequence analyses and increasing the comprehensiveness of the sequence-based techniques. There remains a need, however, for a comprehensive method of detecting mutations in individual gene samples that is both accurate enough to provide a reliable diagnosis to an individual patient and efficient enough to be practical for application to the general population.  
       [0009] Until now, the art has relied upon the occasional occurrence of a previously unreported mutation to increase its base of information for mutation testing in a given gene sequence. To determine the presence or absence of a mutation in a gene from a patient sample, the vast majority of test samples would be subject to complete end-to-end sequencing of the gene. This method is time consuming, often taking six weeks to obtain a result, and is extremely expensive. To ascertain the clinical significance of a previously unidentified sequence variation, those in the art would frequently rely on epidemiological data derived from an analysis of families or populations carrying the newly identified mutation. Other methods of assessing the significance of a newly identified sequence variation would include cloning the altered gene and studying its function in vitro or in vivo or comparing the altered gene sequence with homologous genes in other organisms. Given the realities of many of these genetic diseases, such an analysis comes too late to be of use to the individual bearing the newly identified sequence variation.  
       [0010] There is need in the art, therefore, for improved methods to identify clinically significant mutations. Identification of mutations of the BRCA1 gene would allow better tumor cell analysis for more appropriate therapy, and more widespread diagnostic screening for hereditary cancers than is currently possible, and also permit identification of critical or biologically significant functional areas deduced from the mutational spectrum observed. While mutations occur throughout the BRCA1 gene, there is a need for an assay, test or means for detecting mutations with a high sample number (throughput), sensitivity, accuracy and cost effectiveness.  
       [0011] The present invention addresses these needs and more by providing mutations, molecules, and methods useful for the identification of both known and unknown mutations.  
       SUMMARY OF THE INVENTION  
       [0012] It is an object of the invention to provide a method for determining a predisposition or higher susceptibility to cancers in individuals by determining the DNA sequence of the BRCA1 genes in the DNA of a patient specimen and comparing it to a naturally occurring (wild type) BRCA1 gene sequence or any haplotype thereof resulting from polymorphisms to determine whether the sample contains a mutation.  
       [0013] It is a further object of the invention to provide a method of characterizing and classifying a tumor and determining an appropriate therapy dependant upon the type of BRCA1 mutation(s) present.  
       [0014] It is also an object of the present invention to provide a non-chromosomal mutant BRCA1 gene and expressed mutant protein for drug development, gene therapy and other uses to prevent or ameliorate the effects of or resulting from the mutant BRCA1 gene.  
       [0015] It is another object of the present invention to prepare oligonucleotides, or groups of these oligonucleotides, where the oligonucleotide will specifically hybridize to either the wild type BRCA1 gene or a mutant BRCA1 gene to distinguish between the two BRCA1 genes.  
       [0016] It is still another object of the present invention to assay for the presence of a BRCA1 gene encoding a truncated BRCA1 protein by testing for the presence of a truncated BRCA1 protein.  
       [0017] The present invention is based on the discovery of numerous mutations in the published BRCA1 DNA sequence that result in a truncation of the BRCA1 protein. Mutations in the BRCA1 gene that cause truncations are associated with increased susceptibility to, and developmental stage of, different cancers, particularly breast and ovarian cancer. A truncated protein is likely to be non-functional or at least have a different biological activity.  
       DETAILED DESCRIPTION OF THE INVENTION  
       [0018] The present invention stems, in part, from the realization that previously unidentified sequence variations as a whole are typically of unknown clinical significance. At this time, epidemiological studies are time-consuming and may be of little use for infrequently identified sequence variations; laboratory studies of protein function are similarly time-consuming and difficult to extrapolate to human disease. However, mutations resulting in a prematurely terminated protein have a high probability of having clinical significance. In part, this is due to the fact that a premature termination of a coding sequence may entirely delete important functional domains, such as zinc fingers, transmembrane domains, phosphorylation sites, glycosylation sites, etc. It is also due, in part, to the fact that the removal of a portion of a protein molecule can significantly disrupt a protein&#39;s structure and function, even where no obvious functional domain has been deleted. Thus, the larger the truncation, the greater the likelihood that an important part of the molecule has been removed. Regardless of the cause, a survey of known clinically significant sequence variations (mutations) of the BRCA1 gene reveals that a large percentage of identified mutations are premature truncation mutations of the BRCA1 protein product. Thus, identifying those sequence variations that are premature truncation-causing mutations offers enormous predictive value to the clinician.  
       [0019] The presence of tumor cells with a mutation that inactivates BRCA1 may be clinically significant in determining the tumor stage, likelihood of metastasis, appropriate therapy etc. BRCA1 mutations appear in advanced tumors, several advanced primary cancers and cell lines derived from highly aggressive cancers. Individuals with one of their alleles having a BRCA1 mutation in their germline are at increased susceptibility for cancer, particularly breast and ovarian cancer.  
       [0020] With DNA sequencing technology, genomic DNA has been extracted from samples of whole blood, a cell line or a tumor and the coding regions of the BRCA1 gene were amplified using the polymerase chain reaction (PCR). Each of the coding regions has been sequenced completely and is recited in GENBANK, Accession Number 159546.  
       [0021] A number of mutations have been described in the BRCA1 gene that cause stop codons to be formed, thereby encoding a truncated BRCA1 protein. A list of mutations published to date is in TABLE 1.  
       [0022] The nomenclature of the published literature is inconsistent. See, for example, Beaudet et al, Human Mutations, 2: 245-248 (1993), Antonarakis et al, Human Mutations, 4: 166 (1994), Cotton, Human Mutations, 8: 197-202 (1996), and Beutler et al.,  Human Mutations,  8: 203-206 (1996). Consequently, the following nomenclature is used to define the mutations and polymorphisms of the present invention. In defining the mutation, the number indicates the nucleotide number corresponding to the BRCA1 gene sequence where the mutation first occurs. For simplified identification purposes, the BRCA1 sequence of SEQ ID NO:1, of U.S. Pat. No. 5,654,155 (GENBANK Accession number 159546) is used. However, the invention is equally applicable to other BRCA1 sequences. Other BRCA1 sequences (haplotypes) that are polymorphisms or genetic variations of BRCA1 may be used, in which case, a corresponding mutation at the corresponding nucleotide number is present.  
       [0023] Haplotypes are distinguished based on the combination of nucleotides present at particular polymorphic loci. Polymorphic nucleotide sites 2201, 2430, 2731, 3232, 3667, 4427, and 4956 usually define a haplotype. Other polymorphic sites of a BRCA1 gene are at Exon 4 (not coding) 49, IVS8-57, 1186, 2196, and 3238. Less common polymorphisms are at 233G&gt;A, 561-34C&gt;T, exon 9-6delT, 710C&gt;T, 1100A&gt;G, 1985G&gt;T, 2202G&gt;A, 2687T&gt;C, 2933A&gt;G, 3263T&gt;C, 4077T&gt;C, 4145A&gt;G, 4193G&gt;A, 4209-141C&gt;A, 4364A&gt;G, 4932T&gt;C, 5106-68G&gt;A, 5106-92G&gt;A, intronic exon17-G&gt;A, 5232G&gt;T, 5272+66A&gt;G, intronic exon18+A&gt;G, 5396+48 12bp insert, 5396+4712bp insert, intronic exon 22+T&gt;C, 5651C&gt;T, 5657G&gt;A, and UGA+36C&gt;G. See, Couch et al.,  Human Mutations,  8(1):8-18 (1996), where polymorphisms have been reported.  
       [0024] As the BRCA1 gene numbering does not include introns, when the mutation is located within an intron, a nucleotide in the coding sequence +or − a number of nucleotides is given. Insertion mutations are indicated by “ins” and deletion mutations are indicated by “del”. Letters after “ins” or “del” refer to the nucleotide(s) which were inserted or deleted. Alternatively, where several bases have been inserted or deleted, a number may follow “ins” or “del,” indicating the number of affected bases. When the mutation results in one nucleotide being substituted for another, the original nucleotide(s) is placed to the left of the nucleotide number and the nucleotide(s) corresponding to the substituting nucleotide is placed to the right of the nucleotide number. In some cases, the substitution is indicated by both the original and the substituted nucleotides following the nucleotide number, with an “&gt;” between them. In such cases the original nucleotide is to the left of the “&gt;” and the substituted nucleotide is to the right of the “&gt;,” as for example, in the designation 5657G&gt;A.  
       TABLE 1  
       [0025] 185delAG, 185insA, 188del11, 189insA, 189insTGTC, 192del2, 259insT, 351delA, 448insA, 448delAG, 525insA, 589delCT, 613insT, 633delC, 787insA, 788delA, 794delT, 795delT, 816delGT, 916delTT, 917delTT, 926ins11, 962del4, 1048delA, 1049delG, 1099delCA, 1100delAT, 1103insC, 1129delA, 1135insA, 1191delC, 1201del11, 1205delGA, 1206delA, 1220insC, 1240delC, 1294del40, 1323delG, 1374delG, 138del29, 1395delT, 1406insA, 1411insT, 1438delT, 1459insG, 1479delAG, 1499insA, 1505delG, 1506delA, 1509delA, 1511insC, 151insC, 1559insA, 1611delC, 1623del5, 1670delT, 1675delA, 1701del7, 1768delA, 1832delS, 1942del4, 1996ins4, 2000del4, 2012insT, 2071insA, 2072del4, 2072insG, 2080delA, 2080delA, 2080insA, 2138delA, 2140delC, 2187delA, 2190delA, 2198delCA, 2229delAA, 2274insA, 2294delG, 2295delC, 2307insG, 2312del5, 2313del5, 2314del5, 231delAA, 2325delG, 2329delC, 2329delCA, 2334insCT, 2388delG, 2401delAA, 2415delAG, 2448delT, 2473insA, 2509delAA, 2569delG, 2575delC, 2576delC, 2594delC, 2594insA, 2595delA, 2596delC, 2711delA, 2731insT, 2765delTGC, 2795del4, 2798del4, 2800delAA, 2804delAA, 2809insA, 2819delTT, 2844del4, 2846delTCAA, 2862delTC, 2867insA, 2883del4, 2911delTGGT, 2925del4, 2953delGTA&gt;insC, 2953insCdelGTA, 2954insT, 2982del5, 3039delTT, 3109insAA, 3121 delA, 3124delA, 3135del4, 3166ins5, 3172ins5, 3345delAG, 3345delAG, 3375insGA, 339insA, 3407delAA, 3411delCT, 3449insA, 3450del4, 3476delT, 3596del4, 3599dell, 3600del11, 3604delA, 3668delAGinsT, 3731delA, 3768insA, 3818delA, 3819del5, 3825del8, 3829delT, 3874del4, 3875del4, 3879insT, 3879insT, 3883insA, 3889delAG, 3890delGG, 3896delT, 3938insG, 3960delCA, 3977del4, 3988delAA, 4035delTT, 4050del4, 4091delG, 4154delA, 4184del4, 4239delAG, 4280delTC, 4284delAG, 4601delAA, 4693delAA, 5055delG, 5061delA, 5083del19, 5085del19, 5085del19, 5124delG, 5124delG, 5145del11, 5145del11, 5149del4, 5149del4, 5154del5, 5154del5, 5245delG, 5256delG, 5296del4, 5348delAA, 5382insC, 5389del7, 5404insG, 5438insC, 5439delAA, 5502insT, 5559delG, 5598insGA, 5629delG, 5640delA, 5677insA, A1518T, A2154T, C1599T, C1648G,. C1695T, C1740T, C1806T, C2257G, C2428A, C2457T, C297T, C3042T, C3508G, C3549T, C3726T, C3726T, C3726T, C3726T, C3837T, C3904A, C3960T, C3960T, C3960T, C4086T, C4302T, C4305T, C4341T, C4377T, C4446T, C4808G, C4929T, C5370T, C5622T, C624T, G1081A, G1177A, G1235A, G1371T, G1569T, G2307T, G2508T, G2841T, G3297T, G3759T, G3780T, G3867T, G4740T, G5199T, G5273A, G5292T, G5465A, G546T, G5563A, G5625T, G5630A, IVS12-1643del3835, IVS12-1643del3835, T1411G, T2035A, T3053G, T3358A, T3376G, T3458G, T5298A.  
       [0026] It should be noted that polymorphisms in the coding sequence are known and listed in TABE 2. An example is A180G. In the non-coding regions, a deleted T, 2 base pairs beyond exon 19 (5312+2delT) and a 12 base pair insertion 47 bases beyond exon 20 (5396+47ins12bp) are also known polymorphisms. Other genetic changes which may be polymorphisms or mutations are listed under mutations above. While the present invention references the sequences recited above, it is recognized that polymorphisms, either these recited or others, may be equally used for the purposes of the present invention.  
       TABLE 2  
       [0027] del exon 3, del561-702, del561-789, exon 18 delA, 5312+2delT, codong 1749 Pro to Arg, IVS20ins12, dup5396+48, A1100G, G1112C, C1120T, A1186G, A1186G, A120G, M11, D369del, T1256G, G1503A, T151C, A1546G, T1575C, C1605T, G1606A, G1630A, G1639T, T172C, C1735T, A1767C, A180G, 5544delGTT, C1822T, T1831C, T189C, G1985T, exon 9-2A&gt;C, C2053A, G2093C, C212G, C2121T, G2196A, C2198T, C2201T, G2202A, A2286G, C2299T, G233A, G233A, A243G, T2430C, T2434C, G2531C, A2577G, C2596A, C2596A, C2640T, A2646G, T2687C, C2715T, C2731T, C2731T, C2731T, A2933G, T300G, C3030A, T309G, G310A, G310A, G3143A, A3165G, G3202A, A3232G, A3233G, G3238A, G3238A, T3263C, A330G, In6(+3)A&gt;G, A3339G, C3415T, A3446G, T3529C, A3537G, G3543C, C3547T, C3567T, C3567T, A3667G, C3706A, G3720A, G3727A, G3776C, T378G, C3832T, G3867A, T388C, T4077C, A4145G, G4155A, A4158G, G4193A, 4209-141C&gt;A, G4303A, A433G, G4364A, C4380T, C4427T, C4446G, Exon12+6,T&gt;C, G4603T, G4654T, G4719A, G4755A, G5396+48ins12bp, C4801T, C480T, IVS7-3delT, C49T, A4931G, T4932C, A4935G, C4942T, A4956T, A4956G, A5001G, T5002C, T5002C, C5029T, G5040A, G5075A, G5076A, G5112A, G5112A, V1688del, V1688del, G5193A, G5193A, 5194-2A&gt;C, C5214T, G5215A, C5232T, C5242A, C5242A, T5257C, G5263A, IVS18+1G&gt;T, 5272+66A&gt;G, I-18 5272+66G&gt;A, 5272+66G&gt;A, A5277G, 5280delCAG, A5317G, G5332A, A5335G, G5396A, 5396+1 G&gt;A, G5396+1A, 5396+47ins12bp, T5443G, G546A, T5467C, G5482T, T5530A, C5535G, T5542C, T5548G, A5575G, G5586A, 561-34 C&gt;T, G5616A, T5628C, C5651T, 5657G&gt;A, A655G, C676A, G690A, C710T, C710T, G731C, T855G, G876A, G930A, G930C, exon 2-3insAG , IVS20+60ins12, Intron22T&gt;C, T&gt;G ins59bp, exon 9-6delT, G5396+47ins12bp, in18+1G&gt;C, in20-1(G&gt;T), IVS11-2delGT, IVS20ins12, IVS22+5G.A, IVS1-21insAT, IVS11-2A&gt;G, IVS13+1G&gt;T, IVS13+2T&gt;G, IVS13-10C&gt;T, IVS14-2A&gt;G, IVS15+1G&gt;A, IVS16+3G&gt;C, IVS16+6T&gt;C, IVS16-20A&gt;G, IVS16-20A&gt;G, IVS18+6T&gt;G, IVS18-13A&gt;G, IVS2+1G&gt;A, IVS2+IG&gt;T, IVS2-1 delT, IVS2-12C&gt;G, IVS20+60ins12, IVS20-1G&gt;A, IVS22+8T&gt;C, IVS23-10C&gt;A, IVS4-IG&gt;T, IVS5+1G&gt;T, IVS5-11T&gt;G, IVS5-12A&gt;G, IVS6+7G&gt;A, IVS6-2A&gt;T, IVS6-2delA, IVS7-3delT, IVS8+2T&gt;A, IVS8-17G&gt;T, IVS9+3G&gt;A, exon24(+36)C&gt;G, 3′UTR C&gt;G (+36).  
       [0028] It should be noted that not all of the mutations listed in TABLES 1 and 2 are prior art as some of the mutations were published very recently after applicant determined his mutations.  
       [0029] Mutations detected according to the present invention are nonsense and frame shift mutations. Nonsense mutations cause an in-frame stop codon, which results in expression of a to truncated protein of presumably no BRCA1 functional ability or at least a significantly altered BRCA1 biological activity. Frameshift mutations cause an out-of-frame stop codon to be created in the inserted or deleted coding sequence. This formed stop codon may be at the site of mutation or downstream from the mutation. For the example of nonsense mutations, a nucleotide in a codon is mutated to provide a stop codon having a sequence of TAA, TAG or TGA. For the example of a frame shift mutation, 1, 2, 4, 5, or any larger integer not 3 or a multiple of three, nucleotides are inserted into, or deleted from, the BRCA1 gene sequence. Such mutations result in the formation of a stop codon at the codon containing the mutation or within codons downstream from the mutation site, but before the end of the wild type BRCA1 gene.  
       [0030] The presence of one or more of such mutations is expected to be clinically significant as they are capable of producing a truncating BRCA1 mutation. As the effects of truncations are predictably harmful, one has a high degree of certainty that the presence of such a mutation is clinically significant.  
       [0031] For example, truncating mutations 5382insC, 5438insC, and 185delAG are known to be associated with cancer (Abeliovich, et al.,  Am. J. Hum. Genet.,  60:505-514 (1997); Struewing et al.,  Nat. Genetics,  11:198-200 (1995); Shattuck-Eidens, et al.,  JAMA  273(7):535-541 (1995). Accordingly, any truncating mutation deleting the same portion or more of the coding sequence is presumed to produce an affected mutant BRCA1 protein and to be associated with cancer or an increased susceptibility to cancer. 5382insC and 5438insC cause frame shifts, producing a stop codon (TGA) at nucleotides 5604-5606. 185delAG causes a frame shift, producing a stop codon (TGA) at nucleotides 234-236. Therefore, for the purposes of the present invention, truncating mutations at this location of a lower nucleotide number are presumed to be harmful or of clinical significance.  
       [0032] Conversely, the clinical significance of many missense mutations is unclear. Even when isolated from a tumor cell, the exact effect on BRCA1 protein must be independently shown. Theoretically, most variations in the BRCA1 sequence will be missense variations and relatively AD fewer will be truncating mutations. At the present time, the rules are unknown for which missense mutations in BRCA1 are predictably harmful or otherwise clinically significant. The BRCA1 gene is simply not sufficiently characterized, and given the history of mutations in other genes and computer programs attempting to find predictability, missense mutations will continue to be unpredictable. Without a certainty of their clinical significance, simply knowing that a missense variation exists may have no value.  
       [0033] In general, truncated proteins are non-functional or of reduced function by lacking proper biological activity. The presence of a BRCA1 gene encoding a truncated protein has a high probably of being clinically significant. This is in part due to important portions of the BRCA1 protein being located in the truncated region and not present in the expressed mutant protein. Important functional domains include, for example, any part of the active site, transmembrane domains, zinc fingers, phosphorylation sites, glycosylation sites, sites interacting with metal ions, coenzymes, cofactors, other ligands or receptors, etc. Furthermore, removal of part of the protein molecule or addition of amino acids to the sequence can significantly disrupt the secondary, tertiary or quaternary (if any) structure of the protein, even when no obvious functional domain has been deleted by the truncation.  
       [0034] For example, the 5382insC mutation is found in breast and ovarian cancers. This single base insertion creates a stop-codon at codon 1829, truncating the protein at a cysteine residue. This truncation deletes less than 2 percent of the coding sequence of BRCA1 . Accordingly, all truncations that delete this region of the BRCA1 gene would also by inference render the truncated BRCA1 protein non-functional for its putative tumor suppressor function. Mutant BRCA1 genes with even smaller portions of the gene being truncated are also known to be associated with cancer. For example, truncating mutations causing a stop codon at nucleotides 5676-5678, truncating 0.5% of the coding sequence, are also known to be associated with breast cancer (5677insA; Shattuck-Eidens et al.,  JAMA,  273(7):535-541 (1995)). Please note that several mutations in the DNA result in the expression of the same mutant BRCA1 protein because each mutation causes a stop codon to be formed at nucleotide site 5676-5678. This corresponds to codon 1853 (TAC—Tyrosine). Thus, all of these mutations are very likely to cause the same effective result, for example, in terms of susceptibility to cancer or cancer typing. Therefore, detecting these mutations would be diagnostically significant and useful for assessing the susceptibility for cancer. Given these mutations, oligonucleotides complementary to the F regions of these mutations are prepared to assay for the presence of these mutations in a sample.  
       [0035] For the present invention, the truncating mutations are detected in the BRCA1 gene or a fragment thereof which contains a mutation which directly or indirectly causes the formation of an in-frame stop codon (TAA, TAG or TGA) prematurely at any of codons 2 to 1863 A premature in-frame stop codon is one that occurs before the natural stop codon, which does not occur in a wild-type BRCA1 gene and when expressed results in a truncated protein product.  
       [0036] These BRCA1 mutations of the present invention may also be defined as specifically hybridizing to an oligonucleotide probe having the sequence 5′ R1-R2-R3 3′ wherein R1 is an oligonucleotide of at least three nucleotides, R2 is complementary to TAA, TAG or TGA, and R3 is an oligonucleotide of at least three nucleotides, the probe hybridizing to a premature in-frame stop codon on the mutant BRCA1 gene.  
       [0037] Whenever defining an oligonucleotide probe in the present invention, probes capable of potentially hybridizing to the sense strand are referred to. It should be recognized that oligonucleotide probes having a sequence complementary to these oligonucleotide probes may also be used and may specifically hybridize to the anti-sense strand. For diagnostic purposes either may be used, as DNA from biological samples is generally double stranded and contains both the sense and anti-sense strands.  
       [0038] In the present invention, the following BRCA1 mutations of the present invention represent one base changes that result in the formation of an in frame TAA, TAG or TGA. These mutations of the present invention are defined by forming stop codons at specific locations in accordance with TABLE 3. Any expressed protein from BRCA1 genes with these types of mutations should be truncated accordingly. The substituted nucleotide is indicated in lower case letters.  
               TABLE 3                          List of Nonsense Mutations                                 Stop Codon Formed   Nucleotide Number   Base Change                                             TaA   127   T&gt;A           TgA   127   T&gt;g           tAA   144   G&gt;T           tAA   147   G&gt;T           tAA   153   C&gt;T           tAG   174   C&gt;T           tAA   177   A&gt;T           TaA   184   T&gt;A           TgA   184   T&gt;g           tAG   186   G&gt;T           TGa   191   T&gt;A           TGa   200   T&gt;A           tAG   204   G&gt;T           TaG   208   T&gt;A           tAG   213   A&gt;T           tAA   216   G&gt;T           tAG   231   A&gt;T           TGa   236   T&gt;A           TGa   251   C&gt;A           tAA   252   A&gt;T           TGa   260   C&gt;A           tAA   267   A&gt;T           tAG   279   C&gt;T           tAG   282   A&gt;T           tAA   285   A&gt;T           TaA   295   C&gt;A           TgA   295   C&gt;g           tAG   297   C&gt;T           TGa   302   T&gt;A           TaA   307   T&gt;A           TgA   307   T&gt;g           TGa   311   T&gt;A           tAG   312   A&gt;T           tAA   327   A&gt;T           tAA   339   C&gt;T           tAA   342   G&gt;T           tGA   351   A&gt;T           tAA   360   C&gt;T           tAA   369   G&gt;T           tAG   372   G&gt;T           TaG   379   T&gt;A           tAA   381   A&gt;T           TGa   392   T&gt;A           tAG   399   C&gt;T           TaG   415   T&gt;A           tAG   417   G&gt;T           TAa   422   T&gt;A           TAg   422   T&gt;G           TAa   434   T&gt;A           TAg   434   T&gt;G           tAA   444   A&gt;T           tAG   447   A&gt;T           tAA   450   G&gt;T           tAA   465   G&gt;T           tAA   474   A&gt;T           tAA   480   G&gt;T           tAA   495   C&gt;T           TAa   509   C&gt;A           TAg   509   C&gt;G           tGA   510   A&gt;T           tAA   522   A&gt;T           tGA   525   A&gt;T           tAG   534   C&gt;T           tAA   540   G&gt;T           tAA   546   G&gt;T           TaG   559   T&gt;A           tAG   561   C&gt;T           tAA   564   G&gt;T           tAA   582   C&gt;T           tGA   597   G&gt;T           tGA   606   A&gt;T           tAG   621   A&gt;T           tAG   624   C&gt;T           tAA   633   C&gt;T           tAA   639   C&gt;T           tAG   642   A&gt;T           TAa   656   C&gt;A           TAg   656   C&gt;G           tAA   660   G&gt;T           TaG   664   T&gt;A           tGA   666   G&gt;T           tAA   681   G&gt;T           tAG   696   A&gt;T           TAa   707   T&gt;A           TAg   707   T&gt;G           TGa   710   C&gt;A           tGA   717   G&gt;T           tAA   723   C&gt;T           tAA   726   G&gt;T           TaG   730   T&gt;A           TaA   733   T&gt;A           TgA   733   T&gt;g           tAA   735   C&gt;T           tAA   747   C&gt;T           tGA   750   G&gt;T           tAA   762   G&gt;T           TaG   772   T&gt;A           tAA   783   A&gt;T           tAG   786   A&gt;T           TGa   797   T&gt;A           tAA   798   G&gt;T           tAG   807   G&gt;T           tAA   828   G&gt;T           tAA   837   C&gt;T           TaG   856   T&gt;A           tAG   867   G&gt;T           tAG   870   A&gt;T           tAG   882   G&gt;T           tAA   894   G&gt;T           tAG   897   A&gt;T           TAa   902   T&gt;A           TAg   902   T&gt;G           tAG   903   C&gt;T           TaA   919   C&gt;A           TgA   919   C&gt;g           TaG   925   T&gt;A           tAG   933   G&gt;T           TGa   941   T&gt;A           TaA   964   C&gt;A           TgA   964   C&gt;g           TaA   967   T&gt;A           TgA   967   T&gt;g           tAG   969   C&gt;T           tAG   975   G&gt;T           TaA   988   T&gt;A           TgA   988   T&gt;g           TaA   991   T&gt;A           TgA   991   T&gt;g           tAA   999   A&gt;T           tGA   1005   A&gt;T           tAA   1017   G&gt;T           tAG   1020   A&gt;T           tAA   1026   G&gt;T           TGa   1034   T&gt;A           tAA   1038   A&gt;T           tAA   1044   A&gt;T           tAG   1047   C&gt;T           TaA   1057   T&gt;A           TgA   1057   T&gt;g           tAA   1068   C&gt;T           tGA   1077   A&gt;T           TaG   1081   G&gt;A           TGa   1082   G&gt;A           tGA   1086   G&gt;T           tAG   1092   A&gt;T           tAA   1095   G&gt;T           TGa   1103   T&gt;A           tAA   1128   G&gt;T           tAA   1131   A&gt;T           tAG   1134   A&gt;T           TGa   1163   T&gt;A           tAG   1164   G&gt;T           tGA   1167   A&gt;T           tAA   1170   A&gt;T           tAA   1173   G&gt;T           TaG   1177   G&gt;A           TGa   1178   G&gt;A           tAG   1182   A&gt;T           tAG   1185   C&gt;T           tAA   1188   A&gt;T           TGa   1199   C&gt;A           TaA   1201   C&gt;A           TgA   1201   C&gt;g           tAG   1203   G&gt;T           tGA   1212   A&gt;T           tAA   1221   G&gt;T           TaG   1234   G&gt;A           TGa   1235   G&gt;A           tAG   1257   C&gt;T           tAA   1260   A&gt;T           tAG   1269   G&gt;T           TaG   1273   G&gt;A           TGa   1274   G&gt;A           tGA   1281   A&gt;T           tAA   1290   G&gt;T           TaA   1297   T&gt;A           TgA   1297   T&gt;g           TaA   1312   C&gt;A           TgA   1312   C&gt;g           tAG   1323   G&gt;T           tAA   1329   G&gt;T           TaA   1333   C&gt;A           TgA   1333   C&gt;g           tAA   1341   A&gt;T           TaG   1357   T&gt;A           tAG   1371   G&gt;T           tAA   1380   G&gt;T           TAa   1385   T&gt;A           TAg   1385   T&gt;G           TaA   1396   C&gt;A           TgA   1396   C&gt;g           tAG   1398   G&gt;T           tAA   1401   A&gt;T           TaA   1411   T&gt;A           TgA   1411   T&gt;g           tAG   1431   G&gt;T           TaA   1438   T&gt;A           TgA   1438   T&gt;g           TGa   1445   T&gt;A           tAA   1446   A&gt;T           tAA   1452   G&gt;T           tGA   1455   A&gt;T           tAA   1467   A&gt;T           TaA   1471   C&gt;A           TgA   1471   C&gt;g           tAG   1476   G&gt;T           tAA   1488   G&gt;T           tAA   1494   A&gt;T           tAA   1506   A&gt;T           TAa   1514   T&gt;A           TAg   1514   T&gt;G           tAG   1518   A&gt;T           tAG   1521   A&gt;T           TaA   1540   T&gt;A           TgA   1540   T&gt;g           tAA   1554   G&gt;T           tGA   1569   G&gt;T           tAG   1584   G&gt;T           tAG   1590   C&gt;T           tAA   1599   C&gt;T           tAG   1602   G&gt;T           tAA   1620   A&gt;T           TaA   1624   T&gt;A           TgA   1624   T&gt;g           tAG   1626   A&gt;T           tAA   1632   A&gt;T           tGA   1638   A&gt;T           TaA   1648   C&gt;A           TgA   1648   C&gt;g           tAG   1662   G&gt;T           tAG   1674   A&gt;T           tAA   1677   A&gt;T           TaG   1687   T&gt;A           tAA   1695   C&gt;T           tAG   1698   A&gt;T           tAA   1707   G&gt;T           tAG   1719   C&gt;T           tGA   1722   G&gt;T           tAA   1731   C&gt;T           tAG   1737   G&gt;T           tAG   1740   C&gt;T           tAA   1749   C&gt;T           tAG   1779   G&gt;T           tAA   1785   A&gt;T           tAA   1791   A&gt;T           tAG   1806   C&gt;T           tAG   1812   G&gt;T           tAA   1815   A&gt;T           tAA   1833   G&gt;T           TaA   1837   C&gt;A           TgA   1837   C&gt;g           tAA   1842   G&gt;T           tAA   1845   A&gt;T           tAA   1848   G&gt;T           tAA   1860   A&gt;T           tAA   1866   A&gt;T           tAA   1872   G&gt;T           tAA   1902   G&gt;T           tAA   1908   G&gt;T           TaA   1912   T&gt;A           TgA   1912   T&gt;g           TaA   1927   C&gt;A           TgA   1927   C&gt;g           tAA   1929   A&gt;T           tAA   1938   A&gt;T           tAG   1941   A&gt;T           tAG   1959   A&gt;T           tAA   1989   G&gt;T           tGA   2004   A&gt;T           TGa   2027   T&gt;A           tAA   2031   G&gt;T           TaG   2035   T&gt;A           tAA   2037   C&gt;T           TGa   2051   T&gt;A           tAA   2061   G&gt;T           tAG   2064   G&gt;T           tAG   2070   A&gt;T           tAA   2073   A&gt;T           tAA   2076   A&gt;T           tAG   2079   A&gt;T           TAa   2084   C&gt;A           TAg   2084   C&gt;G           tAA   2088   C&gt;T           tGA   2109   A&gt;T           tAA   2118   C&gt;T           tAA   2127   G&gt;T           tAA   2133   A&gt;T           tAA   2136   G&gt;T           tGA   2148   G&gt;T           tAG   2154   A&gt;T           tAG   2157   A&gt;T           tAG   2166   A&gt;T           tAA   2175   G&gt;T           tAG   2178   C&gt;T           tAA   2187   A&gt;T           tGA   2190   A&gt;T           tAG   2214   G&gt;T           tAG   2220   A&gt;T           TaA   2224   T&gt;A           TgA   2224   T&gt;g           tAG   2250   A&gt;T           TGa   2255   T&gt;A           TaA   2257   C&gt;A           TgA   2257   C&gt;g           tAA   2268   G&gt;T           tAA   2274   A&gt;T           tAA   2277   G&gt;T           tGA   2301   A&gt;T           tAA   2304   G&gt;T           tAA   2307   G&gt;T           tAA   2310   A&gt;T           tAA   2313   G&gt;T           tAG   2316   G&gt;T           tAA   2319   A&gt;T           tAA   2325   G&gt;T           tAA   2334   A&gt;T           tAA   2352   G&gt;T           tAA   2361   A&gt;T           TaA   2374   T&gt;A           TgA   2374   T&gt;g           tGA   2379   G&gt;T           tAA   2382   G&gt;T           TaG   2392   T&gt;A           tAA   2394   C&gt;T           tAA   2400   G&gt;T           tGA   2403   A&gt;T           tAG   2412   G&gt;T           TaA   2428   C&gt;A           TgA   2428   C&gt;g           TAa   2450   T&gt;A           TAg   2450   T&gt;G           tAG   2457   C&gt;T           tAA   2460   G&gt;T           TaG   2470   C&gt;A           TaA   2473   T&gt;A           TgA   2473   T&gt;g           tAA   2478   G&gt;T           tAG   2496   A&gt;T           tAA   2502   A&gt;T           tAA   2508   G&gt;T           tAA   2517   A&gt;T           TGa   2522   T&gt;A           tAG   2529   C&gt;T           TGa   2534   T&gt;A           tAA   2544   G&gt;T           tAG   2553   A&gt;T           tGA   2556   G&gt;T           TGa   2573   T&gt;A           tAA   2577   A&gt;T           tGA   2586   A&gt;T           tAA   2598   G&gt;T           tAG   2607   A&gt;T           TAa   2612   T&gt;A           TAg   2612   T&gt;G           TaG   2617   T&gt;A           tGA   2619   G&gt;T           tAA   2625   G&gt;T           tAA   2643   G&gt;T           tAA   2655   G&gt;T           tAA   2661   G&gt;T           tAA   2664   G&gt;T           tAA   2670   G&gt;T           tAG   2682   C&gt;T           TAa   2687   T&gt;A           TAg   2687   T&gt;G           TaG   2689   T&gt;A           tAG   2691   C&gt;T           tAG   2703   A&gt;T           TaA   2710   C&gt;A           TgA   2710   C&gt;g           tAG   2712   A&gt;T           tAG   2718   C&gt;T           TaA   2722   C&gt;A           TgA   2722   C&gt;g           TaA   2737   C&gt;A           TgA   2737   C&gt;g           tGA   2745   G&gt;T           tAA   2754   G&gt;T           tAG   2757   G&gt;T           tAA   2760   G&gt;T           TGa   2765   T&gt;A           TaA   2794   T&gt;A           TgA   2794   T&gt;g           tAG   2796   A&gt;T           tAA   2799   A&gt;T           tAA   2802   C&gt;T           tAA   2811   A&gt;T           tAA   2823   G&gt;T           TGa   2828   T&gt;A           tAA   2829   G&gt;T           tAA   2832   C&gt;T           tAG   2835   A&gt;T           tAA   2838   G&gt;T           tAA   2841   G&gt;T           tAA   2847   C&gt;T           tGA   2850   G&gt;T           tAG   2853   A&gt;T           tAG   2859   G&gt;T           tAG   2871   A&gt;T           tAG   2880   C&gt;T           tAG   2919   C&gt;T           tAA   2922   A&gt;T           tAG   2928   A&gt;T           tAA   2946   A&gt;T           TGa   2951   T&gt;A           tAA   2958   A&gt;T           tGA   2961   G&gt;T           TGa   2978   T&gt;A           TaA   2983   C&gt;A           TgA   2983   C&gt;g           tAG   2988   C&gt;T           tGA   2994   A&gt;T           tAA   3003   G&gt;T           tGA   3009   G&gt;T           tAA   3027   A&gt;T           tGA   3033   G&gt;T           TaA   3040   T&gt;A           TgA   3040   T&gt;g           tAA   3042   C&gt;T           TAa   3053   T&gt;A           TAg   3053   T&gt;G           tAG   3078   A&gt;T           TaA   3082   C&gt;A           TgA   3082   C&gt;g           tAA   3090   A&gt;T           tAA   3096   A&gt;T           TGa   3101   T&gt;A           tAG   3102   A&gt;T           tAA   3105   A&gt;T           tAG   3117   G&gt;T           tAA   3120   G&gt;T           tAG   3129   G&gt;T           tAA   3132   G&gt;T           TaA   3139   C&gt;A           TgA   3139   C&gt;g           TaA   3145   C&gt;A           TgA   3145   C&gt;g           tAA   3150   G&gt;T           tGA   3153   A&gt;T           tAA   3156   G&gt;T           tGA   3162   G&gt;T           tAG   3168   G&gt;T           tGA   3213   A&gt;T           tAA   3216   G&gt;T           tAA   3228   A&gt;T           tGA   3231   G&gt;T           TaA   3241   C&gt;A           TgA   3241   C&gt;g           tAA   3255   G&gt;T           tAA   3276   G&gt;T           tAA   3297   G&gt;T           tAA   3315   G&gt;T           tAA   3324   C&gt;T           tAA   3330   G&gt;T           tGA   3339   A&gt;T           tGA   3345   A&gt;T           tAA   3354   A&gt;T           TaG   3358   T&gt;A           tGA   3372   A&gt;T           TaA   3376   T&gt;A           TgA   3376   T&gt;g           TaG   3385   T&gt;A           tAA   3387   C&gt;T           tAG   3393   G&gt;T           TAa   3401   T&gt;A           TAg   3401   T&gt;G           tAA   3402   A&gt;T           tAA   3405   C&gt;T           tGA   3417   G&gt;T           TGa   3428   T&gt;A           tAG   3429   A&gt;T           tAA   3438   G&gt;T           tAA   3444   A&gt;T           tAG   3447   A&gt;T           tAA   3450   C&gt;T           tAA   3453   G&gt;T           TAa   3458   T&gt;A           TAg   3458   T&gt;G           tAA   3459   G&gt;T           tAA   3462   G&gt;T           tAG   3471   C&gt;T           TAa   3500   T&gt;A           TAg   3500   T&gt;G           TaA   3508   C&gt;A           TgA   3508   C&gt;g           TaA   3517   T&gt;A           TgA   3517   T&gt;g           tAA   3519   G&gt;T           tAG   3522   C&gt;T           tGA   3531   G&gt;T           tAG   3549   C&gt;T           TGa   3557   T&gt;A           tAG   3561   G&gt;T           TaA   3580   T&gt;A           TgA   3580   T&gt;g           tAA   3591   G&gt;T           tAG   3597   A&gt;T           tAA   3600   G&gt;T           tAA   3618   G&gt;T           tAG   3630   A&gt;T           tAA   3633   G&gt;T           tAA   3654   A&gt;T           tAG   3663   C&gt;T           tGA   3666   A&gt;T           tGA   3669   G&gt;T           tAG   3672   G&gt;T           TaG   3712   T&gt;A           tAG   3717   C&gt;T           TAa   3725   C&gt;A           TAg   3725   C&gt;G           tGA   3726   C&gt;T           tGA   3729   A&gt;T           tAG   3738   A&gt;T           tAA   3741   A&gt;T           TaA   3745   T&gt;A           TgA   3745   T&gt;g           tAG   3747   G&gt;T           TaA   3754   C&gt;A           TgA   3754   C&gt;g           tAA   3756   G&gt;T           tAG   3759   G&gt;T           TaA   3766   T&gt;A           TgA   3766   T&gt;g           tAG   3774   G&gt;T           tAA   3780   G&gt;T           tAG   3783   G&gt;T           TGa   3794   C&gt;A           tAA   3798   C&gt;T           TaG   3805   T&gt;A           TaA   3808   T&gt;A           TgA   3808   T&gt;g           tAA   3816   A&gt;T           tAG   3837   C&gt;T           tAG   3867   G&gt;T           TGa   3872   T&gt;A           tAG   3879   A&gt;T           tAG   3888   G&gt;T           tAG   3891   G&gt;T           TaA   3898   T&gt;A           TgA   3898   T&gt;g           TaA   3901   T&gt;A           TgA   3901   T&gt;g           TaA   3904   C&gt;A           TgA   3904   C&gt;g           TaG   3907   T&gt;A           tAG   3909   A&gt;T           TaA   3919   T&gt;A           TgA   3919   T&gt;g           TGa   3929   C&gt;A           tAG   3936   C&gt;T           TaG   3946   T&gt;A           tAG   3951   A&gt;T           tAG   3960   C&gt;T           tAA   3963   G&gt;T           tAG   3978   G&gt;T           tAA   3981   G&gt;T           tAA   3987   A&gt;T           TGa   3992   T&gt;A           TaG   4003   T&gt;A           TaA   4012   C&gt;A           TgA   4012   C&gt;g           tAG   4014   C&gt;T           TGa   4019   C&gt;A           tAA   4023   G&gt;T           TaG   4027   T&gt;A           tAA   4029   G&gt;T           TaG   4036   T&gt;A           tAG   4056   C&gt;T           TaG   4069   T&gt;A           tAA   4083   A&gt;T           tAA   4086   C&gt;T           tAG   4098   C&gt;T           tAA   4104   G&gt;T           tAG   4110   C&gt;T           tGA   4113   G&gt;T           tAG   4131   A&gt;T           tAA   4134   G&gt;T           TaG   4138   T&gt;A           TaA   4144   C&gt;A           TgA   4144   C&gt;g           tAA   4152   G&gt;T           tAA   4155   G&gt;T           tGA   4158   A&gt;T           tGA   4161   G&gt;T           TaG   4171   T&gt;A           tAA   4173   G&gt;T           tAA   4176   G&gt;T           tAA   4185   C&gt;T           tAA   4188   G&gt;T           tAG   4191   G&gt;T           tAA   4194   C&gt;T           TaA   4207   C&gt;A           TgA   4207   C&gt;g           TaA   4213   T&gt;A           TgA   4213   T&gt;g           tAA   4218   G&gt;T           TGa   4235   T&gt;A           tAG   4236   G&gt;T           tAA   4242   G&gt;T           tAA   4257   G&gt;T           TGa   4265   C&gt;A           TaA   4267   C&gt;A           TgA   4267   C&gt;g           tAG   4281   C&gt;T           TaA   4294   T&gt;A           TgA   4294   T&gt;g           tAG   4302   C&gt;T           tAG   4305   C&gt;T           tAA   4320   C&gt;T           tAG   4335   A&gt;T           tAG   4341   C&gt;T           tAG   4344   C&gt;T           tAA   4347   G&gt;T           tAA   4356   G&gt;T           tAA   4362   G&gt;T           TaA   4372   T&gt;A           TgA   4372   T&gt;g           tAA   4374   G&gt;T           tAG   4377   C&gt;T           tAG   4389   C&gt;T           TAa   4406   C&gt;A           TAg   4406   C&gt;G           tAG   4437   G&gt;T           tGA   4446   C&gt;T           tAA   4455   G&gt;T           tAA   4458   C&gt;T           TaA   4468   C&gt;A           TgA   4468   C&gt;g           tAA   4470   G&gt;T           tAA   4473   A&gt;T           TaA   4483   T&gt;A           TgA   4483   T&gt;g           TaA   4489   C&gt;A           TgA   4489   C&gt;g           tAG   4491   C&gt;T           tAA   4494   A&gt;T           tAA   4503   G&gt;T           TAa   4508   C&gt;A           TAg   4508   C&gt;G           tAG   4518   C&gt;T           tAA   4527   G&gt;T           tAG   4545   A&gt;T           tAG   4551   G&gt;T           tAA   4578   A&gt;T           tAA   4584   A&gt;T           tAA   4587   G&gt;T           tGA   4593   G&gt;T           tAA   4599   G&gt;T           TaA   4606   C&gt;A           TgA   4606   C&gt;g           tAA   4617   A&gt;T           TGa   4622   C&gt;A           TaA   4627   C&gt;A           TgA   4627   C&gt;g           TaA   4630   T&gt;A           TgA   4630   T&gt;g           TaG   4642   G&gt;A           TGa   4643   G&gt;A           TAa   4646   C&gt;A           TAg   4646   C&gt;G           TGa   4658   C&gt;A           tAG   4671   C&gt;T           tGA   4677   A&gt;T           TAa   4685   C&gt;A           TAg   4685   C&gt;G           tAA   4692   C&gt;T           tAG   4695   G&gt;T           tAG   4698   G&gt;T           tAG   4707   A&gt;T           tAG   4722   G&gt;T           tAG   4725   G&gt;T           tAA   4728   C&gt;T           tAG   4731   C&gt;T           tAA   4737   G&gt;T           tAG   4740   G&gt;T           TaG   4759   T&gt;A           tAA   4764   G&gt;T           TAa   4775   C&gt;A           TAg   4775   C&gt;G           TaG   4777   T&gt;A           tAA   4785   C&gt;T           tAG   4794   G&gt;T           tGA   4797   G&gt;T           TAa   4808   C&gt;A           TAg   4808   C&gt;G           tAA   4812   G&gt;T           tGA   4818   G&gt;T           tAA   4845   G&gt;T           tAA   4860   G&gt;T           tGA   4866   A&gt;T           tAG   4875   G&gt;T           TaA   4879   C&gt;A           TgA   4879   C&gt;g           TaA   4906   C&gt;A           TgA   4906   C&gt;g           TaG   4918   T&gt;A           tAA   4920   A&gt;T           tAA   4929   C&gt;T           TaG   4933   T&gt;A           tAA   4935   A&gt;T           tAA   4944   G&gt;T           tAG   4953   C&gt;T           TAa   4994   T&gt;A           TAg   4994   T&gt;G           tAA   5004   G&gt;T           tAA   5007   G&gt;T           tAG   5022   G&gt;T           tAG   5025   A&gt;T           tAA   5031   G&gt;T           TaG   5035   T&gt;A           TaA   5044   C&gt;A           TgA   5044   C&gt;g           tAA   5049   G&gt;T           tAA   5061   A&gt;T           tGA   5064   A&gt;T           tAA   5097   G&gt;T           tAA   5100   G&gt;T           TAa   5117   C&gt;A           TAg   5117   C&gt;G           tAG   5118   A&gt;T           tGA   5127   A&gt;T           tAA   5130   A&gt;T           TaA   5146   T&gt;A           TgA   5146   T&gt;g           tAA   5163   G&gt;T           tAG   5166   G&gt;T           tAA   5187   A&gt;T           tAG   5199   G&gt;T           TGa   5210   T&gt;A           tAA   5211   G&gt;T           tAA   5223   A&gt;T           TAa   5228   T&gt;A           TAg   5228   T&gt;G           tGA   5235   G&gt;T           tGA   5244   G&gt;T           tGA   5247   G&gt;T           tAA   5250   A&gt;T           TaG   5254   G&gt;A           TGa   5255   G&gt;A           TAa   5267   T&gt;A           TAg   5267   T&gt;G           TaG   5272   G&gt;A           TGa   5273   G&gt;A           tAG   5280   C&gt;T           tAA   5289   A&gt;T           tAA   5292   G&gt;T           tGA   5295   A&gt;T           tAA   5298   A&gt;T           tAG   5310   G&gt;T           tAA   5322   G&gt;T           tGA   5328   A&gt;T           tGA   5331   G&gt;T           tGA   5346   G&gt;T           tGA   5349   A&gt;T           tAA   5358   C&gt;T           tAG   5367   A&gt;T           tGA   5370   C&gt;T           tGA   5376   A&gt;T           tAA   5379   G&gt;T           tAG   5385   C&gt;T           tGA   5391   A&gt;T           tAG   5394   A&gt;T           tAA   5412   G&gt;T           TGa   5420   T&gt;A           TGa   5423   C&gt;A           TAa   5426   T&gt;A           TAg   5426   T&gt;G           tAA   5454   C&gt;T           tAA   5460   G&gt;T           TaG   5464   G&gt;A           TGa   5465   G&gt;A           tAG   5472   C&gt;T           TGa   5480   T&gt;A           tAG   5496   A&gt;T           tAG   5499   G&gt;T           TaA   5506   C&gt;A           TgA   5506   C&gt;g           TaA   5509   C&gt;A           TgA   5509   C&gt;g           tAG   5550   C&gt;T           TaG   5563   G&gt;A           TGa   5564   G&gt;A           tAG   5568   G&gt;T           tAG   5595   C&gt;T           TGa   5603   T&gt;A           tAG   5604   G&gt;T           tGA   5622   C&gt;T           tAG   5625   G&gt;T           TaG   5629   G&gt;A           TGa   5630   G&gt;A           TaG   5635   T&gt;A           TAa   5654   C&gt;A           TAg   5654   C&gt;G           tAG   5655   C&gt;T           TGa   5660   C&gt;A           tAG   5661   C&gt;T           tAG   5664   G&gt;T           TAa   5678   C&gt;A           TAg   5678   C&gt;G           tAG   5688   C&gt;T           TAa   5708   C&gt;A           TAg   5708   C&gt;G           TaA   5710   G&gt;A                      
 
       [0039] The genes of the present invention containing nonsense mutations are also defined as BRCA1 genes having the sequence 5′ R1-R2-R3 3′; where R1 is the wild type BRCA1 DNA sequence from codon 1 to X−1; R2 is TAA, TAG or TGA; R3 is the wild type BRCA1 DNA sequence from codon X+1 to 1862; and where X=2 to 1861.  
       [0040] The genes of the present invention containing nonsense mutations are also defined by being capable of specifically hybridizing to an oligonucleotide probe having at least 12 nucleotides in length and having the sequence 5′ R1-R2-R3 3′; where R1 contains at its 3′ end three nucleotides complementary to codon X−1 of the wild-type BRCA1 gene; R2=a sequence complementary to TAG, TGA or TAA; R3 contains at its 5′ end three nucleotides complementary to codon X+1 of the wild type BRCA1 gene; where X=2 to 1862 Other oligonucleotide probes complementary to these probes are also acceptable, hybridizing to the antisense strand. The oligonucleotide probe is unable to specifically hybridize to the wild-type BRCA1 gene with the same binding affinity as to the mutant BRCA1 gene.  
       [0041] The present invention also involves frame shift mutations involving insertions or deletions of 1, 2, 4, 5, 7, 8, or any other number which is not 3 or a multiple of 3, nucleotides. Single base deletions of the present invention form one or more stop codons as indicated in the following TABLE 4. The formed in-frame stop codon and the location are provided. Any expressed protein from BRCA1 genes with these types of mutations should be truncated accordingly. It should be recognized that the present invention includes deletions of 3n+1 bases, where n is an integer greater than zero and less than 1862. These larger deletions mutations have stop codons at nucleotide numbers corresponding to the listed stop codon at the nucleotide number listed. The corresponding nucleotide numbers of the stop codons will be 3n nucleotides smaller than those listed.  
               TABLE 4                          Single Base Deletions                             Codon Formed   Nucleotide Number                       TAG   183-185           TGA   207-209           TGA   264-266           TGA   249-251           TGA   258-260           TGA   309-311           TAA   321-323           TGA   378-380           TAA   471-473           TAG   420-422           TAA   432-434           TGA   603-605           TAA   507-509           TGA   612-614           TAA   816-818           TAA   654-656           TGA   708-710           TGA   855-857           TGA   1008-1010           TAA   918-920           TAG   1014-1016           TAG   1056-1058           TGA   1032-1034           TAG   1137-1139           TGA   1101-1103           TGA   1143-1145           TAA   1236-1238           TGA   1176-1178           TAG   1200-1202           TGA   1233-1235           TAA   1242-1244           TAG   1296-1298           TAG   1344-1346           TAA   1332-1334           TAA   1365-1367           TAG   1374-1376           TAG   1404-1406           TAG   1395-1397           TAA   1437-1439           TAG   1473-1475           TGA   1443-1445           TAG   1470-1472           TAA   1539-1541           TAA   1548-1550           TAA   1560-1562           TAG   1566-1568           TAA   1593-1595           TAA   1623-1625           TGA   1710-1712           TAG   1647-1649           TAA   1713-1715           TGA   1752-1754           TGA   1755-1757           TAG   1830-1832           TAA   1878-1880           TAA   1890-1892           TAA   1911-1913           TGA   1950-1952           TAA   1926-1928           TAG   1992-1994           TAG   1995-1997           TAA   2010-2012           TAA   2067-2069           TGA   2025-2027           TAA   2067-2069           TGA   2217-2219           TAA   2082-2084           TGA   2217-2219           TAA   2223-2225           TAG   2322-2324           TAA   2256-2258           TAG   2322-2324           TAA   2373-2375           TAG   2409-2411           TAG   2490-2492           TAG   2448-2450           TAG   2490-2492           TGA   2523-2525           TAA   2559-2561           TAG   2652-2654           TAA   2793-2795           TAA   2709-2711           TAA   2793-2795           TAA   2736-2738           TAA   2793-2795           TAG   3114-3116           TGA   2949-2951           TAG   3114-3116           TGA   3099-3101           TAG   3114-3116           TGA   3186-3188           TAA   3138-3140           TGA   3186-3188           TAG   3258-3260           TAA   3240-3242           TAG   3258-3260           TAG   3300-3302           TAG   3333-3335           TGA   3357-3359           TAG   3375-3377           TAA   3441-3443           TAA   3399-3401           TAA   3441-3443           TGA   3426-3428           TAA   3441-3443           TAG   3465-3467           TAG   3456-3458           TAG   3465-3467           TGA   3501-3503           TAG   3516-3518           TAG   3507-3509           TAG   3516-3518           TAG   3579-3581           TAA   3594-3596           TAG   3744-3746           TAA   3819-3821           TAG   3753-3755           TAA   3819-3821           TGA   3906-3908           TAA   3918-3920           TAA   3939-3941           TGA   3927-3929           TAA   3939-3941           TGA   4035-4037           TGA   4017-4019           TGA   4035-4037           TGA   4068-4070           TGA   4089-4091           TGA   4122-4124           TAG   4212-4214           TAG   4143-4145           TAG   4212-4214           TAA   4206-4208           TAG   4212-4214           TAA   4293-4295           TAG   4266-4268           TAA   4293-4295           TGA   4329-4331           TAA   4332-4334           TAG   4359-4361           TAG   4371-4373           TAA   4416-4418           TAA   4482-4484           TAG   4467-4469           TAA   4482-4484           TAA   4512-4514           TAG   4629-4631           TGA   4758-4760           TAA   4644-4646           TGA   4758-4760           TAG   4791-4793           TGA   4917-4919           TAG   4878-4880           TGA   4917-4919           TAA   4905-4907           TGA   4917-4919           TGA   4932-4934           TGA   5013-5015           TAA   4992-4994           TGA   5013-5015           TGA   5034-5036           TGA   5088-5090           TAA   5043-5045           TGA   5088-5090           TAA   5145-5147           TAA   5115-5117           TAA   5145-5147           TAA   5154-5156           TGA   5184-5186           TGA   5220-5222           TAG   5232-5234           TAG   5256-5258           TGA   5274-5276           TGA   5304-5306           TAG   5409-5411           TGA   5493-5495           TAG   5424-5426           TGA   5463-5465           TGA   5616-5618           TGA   5562-5564           TGA   5616-5618           TAG   5643-5645           TGA   5679-5681                      
 
       [0042] Two base deletions of the present invention form stop codons as indicated in the following TABLE 5. The formed in-frame stop codon and its location are provided. Any expressed protein from BRCA1 genes with these types of mutations should be truncated accordingly. It should be recognized that the present invention includes deletions of 3n+2 bases, where n is an integer greater than zero and less than 1862. These larger deletions mutations have stop codons at nucleotide numbers corresponding to the listed stop codon at the nucleotide number listed. The corresponding nucleotide numbers of the stop codons will be 3n nucleotides smaller than those listed.  
               TABLE 5                          Two Base Deletions                             Codon Formed   Nucleotide Number                       TGA   141-143           TAA   162-164           TGA   234-236           TGA   183-185           TGA   234-236           TAA   309-311           TGA   249-251           TGA   309-311           TGA   315-317           TAG   354-356           TGA   366-368           TGA   402-404           TAA   378-380           TGA   402-404           TAA   432-434           TGA   414-416           TAA   432-434           TAA   453-455           TGA   462-464           TGA   477-479           TGA   537-539           TAG   507-509           TGA   537-539           TAA   588-590           TGA   657-659           TGA   669-671           TGA   678-680           TAA   690-692           TAA   693-695           TGA   759-761           TAG   705-707           TGA   759-761           TAG   708-710           TGA   759-761           TGA   795-797           TGA   771-773           TGA   795-797           TGA   804-806           TGA   825-827           TAA   843-845           TAA   846-848           TGA   849-851           TGA   864-866           TAA   855-857           TGA   864-866           TGA   879-881           TAG   906-908           TAA   900-902           TAG   906-908           TGA   972-974           TAA   918-920           TGA   972-974           TAA   996-998           TGA   1023-1025           TGA   1032-1034           TAA   1035-1037           TAA   1071-1073           TAA   1089-1091           TGA   1101-1103           TGA   1104-1106           TAG   1107-1109           TGA   1149-1151           TGA   1161-1163           TAA   1179-1181           TGA   1176-1178           TAA   1179-1181           TAG   1209-1211           TGA   1200-1202           TAG   1209-1211           TGA   1218-1220           TAG   1245-1247           TAA   1263-1265           TGA   1266-1268           TGA   1284-1286           TAG   1278-1280           TGA   1284-1286           TGA   1287-1289           TGA   1302-1304           TGA   1305-1307           TGA   1314-1316           TGA   1326-1328           TGA   1347-1349           TAA   1332-1334           TGA   1347-1349           TGA   1368-1370           TGA   1356-1358           TGA   1368-1370           TGA   1377-1379           TGA   1419-1421           TGA   1395-1397           TGA   1419-1421           TGA   1428-1430           TGA   1443-1445           TGA   1449-1451           TAA   1479-1481           TAA   1464-1466           TAA   1479-1481           TGA   1485-1487           TGA   1551-1553           TAG   1512-1514           TGA   1551-1553           TAG   1539-1541           TGA   1551-1553           TGA   1581-1583           TAA   1617-1619           TAA   1629-1631           TAA   1623-1625           TAA   1629-1631           TGA   1659-1661           TGA   1704-1706           TAA   1725-1727           TAA   1764-1766           TAG   1767-1769           TGA   1776-1778           TAA   1782-1784           TGA   1794-1796           TGA   1809-1811           TAA   1821-1823           TGA   1869-1871           TAA   1857-1859           TGA   1869-1871           TAA   1935-1937           TAA   1911-1913           TAA   1935-1937           TAA   1926-1928           TAA   1935-1937           TAG   1944-1946           TGA   1986-1988           TAG   2001-2003           TAA   2019-2021           TGA   2028-2030           TGA   2040-2042           TAG   2043-2045           TAG   2052-2054           TGA   2058-2060           TAA   2130-2132           TAA   2082-2084           TAA   2130-2132           TAA   2160-2162           TGA   2172-2174           TAA   2184-2186           TGA   2193-2195           TGA   2199-2201           TAA   2247-2249           TGA   2265-2267           TAA   2256-2258           TGA   2265-2267           TAA   2271-2273           TAG   2289-2291           TAA   2331-2333           TAA   2340-2342           TAA   2343-2345           TGA   2349-2351           TGA   2397-2399           TAG   2373-2375           TGA   2397-2399           TAG   2415-2417           TGA   2442-2444           TAG   2481-2483           TAG   2448-2450           TAG   2481-2483           TAA   2514-2516           TGA   2541-2543           TAA   2580-2582           TAA   2574-2576           TAA   2580-2582           TAG   2583-2585           TGA   2589-2591           TAA   2604-2606           TGA   2622-2624           TAA   2628-2630           TGA   2667-2669           TGA   2673-2675           TGA   2820-2822           TAA   2700-2702           TGA   2820-2822           TAA   2709-2711           TGA   2820-2822           TAA   2736-2738           TGA   2820-2822           TAA   2793-2795           TGA   2820-2822           TGA   2826-2828           TGA   2856-2858           TAA   2862-2864           TAA   2886-2888           TAA   2925-2927           TGA   2934-2936           TAA   2937-2939           TAG   2949-2951           TAG   2967-2969           TAA   3024-3026           TAG   2991-2993           TAA   3024-3026           TAA   3087-3089           TAG   3051-3053           TAA   3087-3089           TAA   3093-3095           TGA   3099-3101           TGA   3126-3128           TGA   3147-3149           TGA   3165-3167           TAG   3195-3197           TAA   3201-3203           TAA   3204-3206           TAG   3210-3212           TAA   3225-3227           TAA   3249-3251           TAG   3240-3242           TAA   3249-3251           TGA   3252-3254           TAA   3270-3272           TAG   3264-3266           TAA   3270-3272           TGA   3273-3275           TAA   3291-3293           TAG   3285-3287           TAA   3291-3293           TGA   3294-3296           TGA   3309-3311           TAG   3306-3308           TGA   3309-3311           TGA   3312-3314           TAG   3336-3338           TAG   3369-3371           TAA   3357-3359           TAG   3369-3371           TGA   3390-3392           TAA   3399-3401           TAA   3420-3422           TGA   3426-3428           TGA   3435-3437           TAA   3456-3458           TAA   3477-3479           TAA   3510-3512           TGA   3507-3509           TAA   3510-3512           TAG   3534-3536           TGA   3516-3518           TAG   3534-3536           TGA   3558-3560           TGA   3567-3569           TGA   3570-3572           TGA   3582-3584           TGA   3579-3581           TGA   3582-3584           TGA   3588-3590           TAG   3606-3608           TGA   3615-3617           TGA   3621-3623           TAA   3627-3629           TAG   3648-3650           TAG   3675-3677           TAG   3687-3689           TAG   3768-3770           TAG   3723-3725           TAG   3768-3770           TGA   3744-3746           TAG   3768-3770           TGA   3753-3755           TAG   3768-3770           TGA   3771-3773           TGA   3777-3779           TAA   3813-3815           TAG   3843-3845           TAG   3849-3851           TAA   3876-3878           TAG   3912-3914           TAA   3906-3908           TAG   3912-3914           TGA   3921-3923           TAA   3918-3920           TGA   3921-3923           TAA   3930-3932           TAG   3927-3929           TAA   3930-3932           TAG   3972-3974           TGA   3975-3977           TAG   3996-3998           TGA   4020-4022           TAG   4017-4019           TGA   4020-4022           TGA   4101-4103           TGA   4026-4028           TGA   4101-4103           TAA   4080-4082           TGA   4101-4103           TGA   4125-4127           TGA   4146-4148           TGA   4143-4145           TGA   4146-4148           TGA   4149-4151           TAA   4179-4181           TGA   4170-4172           TAA   4179-4181           TGA   4215-4217           TAA   4206-4208           TGA   4215-4217           TGA   4233-4235           TGA   4239-4241           TGA   4254-4256           TGA   4284-4286           TAA   4323-4325           TGA   4353-4355           TAA   4395-4397           TGA   4371-4373           TAA   4395-4397           TGA   4419-4421           TGA   4434-4436           TAG   4497-4499           TGA   4467-4469           TAG   4497-4499           TGA   4500-4502           TGA   4539-4541           TGA   4548-4550           TAG   4563-4565           TAA   4575-4577           TAA   4581-4583           TAA   4614-4616           TGA   4632-4634           TGA   4629-4631           TGA   4632-4634           TAG   4635-4637           TAG   4674-4676           TGA   4641-4643           TAG   4674-4676           TAA   4704-4706           TGA   4713-4715           TGA   4833-4835           TGA   4836-4838           TGA   4842-4844           TGA   4848-4850           TGA   4857-4859           TGA   4977-4979           TAA   4917-4919           TGA   4977-4979           TAA   4932-4934           TGA   4977-4979           TAA   4992-4994           TAA   5148-5150           TAA   5115-5117           TAA   5148-5150           TGA   5160-5162           TGA   5196-5198           TGA   5208-5210           TAG   5259-5261           TAA   5286-5288           TGA   5307-5309           TGA   5313-5315           TGA   5319-5321           TGA   5601-5603           TAG   5400-5402           TGA   5601-5603           TGA   5421-5423           TGA   5601-5603           TAG   5424-5426           TGA   5601-5603           TGA   5634-5636           TAA   5652-5654           TGA   5658-5660           TAG   5706-5708                      
 
       [0043] Deletion mutations in the BRCA1 gene containing a truncating mutation may also be defined as having the sequence 5′ R1-R2 3′; where R1 is the wild type BRCA1 DNA sequence from nucleotide number 120 to X; R2 contains the wild type BRCA1 DNA sequence from nucleotide number X+Y+1 to 5571, where Y=3n+1 or 3n+2 where n is an integer of zero or greater; and where X=123 to 5707.  
       [0044] Alternatively, the mutations may be defined as being specifically hybridizable to an oligonucleotide probe being at least 12 nucleotides in length and having the sequence 5′ R1-R2 3′; where R1 contains at its 3′ end three nucleotides complementary to nucleotide numbers X-2, X-1 and X the wild-type BRCA1 gene; R2 contains at its 5′ end three nucleotides complementary to nucleotide numbers X+Y+1, X+Y+2, and X+Y+3 of the wild type BRCA1 DNA sequence; where Y=3n+1 or 3n+2 where n is an integer of zero or greater; and where X=122 to 5706.  
       [0045] Single base insertions of the present invention form stop codons as indicated in the following TABLE 6. The formed in-frame stop codon and the location are provided. Any expressed protein from BRCA1 genes with these types of mutations should be truncated accordingly. It should be recognized that the present invention includes insertions of 3n+1 bases, where n is an integer greater than zero and less than 1861. These larger insertions mutations have stop codons at nucleotide numbers corresponding to the listed stop codon at the nucleotide number listed. The corresponding nucleotide numbers of the stop codons will be 3n nucleotides larger than those listed.  
               TABLE 6                          Single Base Insertions                             Codon Formed   Nucleotide Number                       TGA   144-146           TGA   123-125           TGA   144-146           TAA   165-167           TGA   144-146           TAA   165-167           TGA   147-149           TAA   165-167           TAA   156-158           TAA   165-167           TGA   237-239           TAA   165-167           TGA   237-239           TAA   177-179           TGA   237-239           TGA   186-188           TGA   237-239           TAG   189-191           TGA   237-239           TGA   189-191           TGA   237-239           TAG   198-200           TGA   237-239           TGA   198-200           TGA   237-239           TGA   204-206           TGA   237-239           TAA   213-215           TGA   237-239           TGA   216-218           TGA   237-239           TAA   231-233           TGA   237-239           TAG   234-236           TGA   237-239           TGA   234-236           TGA   237-239           TAA   312-314           TGA   237-239           TAA   312-314           TAG   249-251           TAA   312-314           TGA   249-251           TAA   312-314           TAA   252-254           TAA   312-314           TAG   258-260           TAA   312-314           TGA   258-260           TAA   312-314           TAA   267-269           TAA   312-314           TAA   276-278           TAA   312-314           TAA   282-284           TAA   312-314           TAA   285-287           TAA   312-314           TAG   300-302           TAA   312-314           TGA   300-302           TAA   312-314           TAG   309-311           TAA   312-314           TGA   309-311           TAA   312-314           TGA   318-320           TAA   312-314           TGA   318-320           TAA   315-317           TGA   318-320           TAG   357-359           TGA   318-320           TAG   357-359           TAA   327-329           TAG   357-359           TAG   330-332           TAG   357-359           TAG   333-335           TAG   357-359           TGA   342-344           TAG   357-359           TAG   345-347           TAG   357-359           TAG   351-353           TAG   357-359           TGA   369-371           TAG   357-359           TGA   369-371           TGA   405-407           TGA   369-371           TGA   405-407           TGA   372-374           TGA   405-407           TAA   381-383           TGA   405-407           TAG   390-392           TGA   405-407           TGA   390-392           TGA   405-407           TAA   435-437           TGA   405-407           TAA   435-437           TGA   417-419           TAA   435-437           TAA   420-422           TAA   435-437           TGA   420-422           TAA   435-437           TAA   420-422           TAA   435-437           TAG   420-422           TAA   435-437           TAA   426-428           TAA   435-437           TAG   429-431           TAA   435-437           TAA   432-434           TAA   435-437           TGA   432-434           TAA   435-437           TAA   432-434           TAA   435-437           TAG   432-434           TAA   435-437           TAA   456-458           TAA   435-437           TAA   456-458           TAA   444-446           TAA   456-458           TAA   447-449           TAA   456-458           TGA   450-452           TAA   456-458           TAA   453-455           TAA   456-458           TGA   465-467           TAA   456-458           TGA   465-467           TGA   480-482           TGA   465-467           TGA   480-482           TAA   474-476           TGA   480-482           TGA   477-479           TGA   480-482           TGA   540-542           TGA   480-482           TGA   540-542           TAG   498-500           TGA   540-542           TAA   507-509           TGA   540-542           TGA   507-509           TGA   540-542           TAA   507-509           TGA   540-542           TAG   507-509           TGA   540-542           TAG   510-512           TGA   540-542           TAA   513-515           TGA   540-542           TAA   522-524           TGA   540-542           TAG   525-527           TGA   540-542           TAG   537-539           TGA   540-542           TAA   591-593           TGA   540-542           TAA   591-593           TGA   546-548           TAA   591-593           TAA   549-551           TAA   591-593           TGA   564-566           TAA   591-593           TAG   570-572           TAA   591-593           TAG   576-578           TAA   591-593           TGA   660-662           TAA   591-593           TGA   660-662           TAG   606-608           TGA   660-662           TAG   615-617           TGA   660-662           TAA   621-623           TGA   660-662           TAA   642-644           TGA   660-662           TAA   654-656           TGA   660-662           TGA   654-656           TGA   660-662           TAA   654-656           TGA   660-662           TAG   654-656           TGA   660-662           TGA   672-674           TGA   660-662           TGA   672-674           TGA   681-683           TGA   672-674           TGA   681-683           TAA   693-695           TGA   681-683           TAA   693-695           TGA   684-686           TAA   693-695           TAA   696-698           TAA   693-695           TAA   696-698           TGA   762-764           TAA   696-698           TGA   762-764           TAA   705-707           TGA   762-764           TGA   705-707           TGA   762-764           TAA   705-707           TGA   762-764           TAG   705-707           TGA   762-764           TAG   708-710           TGA   762-764           TGA   708-710           TGA   762-764           TAG   711-713           TGA   762-764           TGA   720-722           TGA   762-764           TGA   726-728           TGA   762-764           TAG   756-758           TGA   762-764           TGA   759-761           TGA   762-764           TGA   798-800           TGA   762-764           TGA   798-800           TAG   768-770           TGA   798-800           TGA   774-776           TGA   798-800           TAA   783-785           TGA   798-800           TAA   786-788           TGA   798-800           TAG   795-797           TGA   798-800           TGA   795-797           TGA   798-800           TGA   807-809           TGA   798-800           TGA   807-809           TGA   828-830           TGA   807-809           TGA   828-830           TGA   813-815           TGA   828-830           TAA   822-824           TGA   828-830           TAA   846-848           TGA   828-830           TAA   846-848           TAG   843-845           TAA   846-848           TAA   849-851           TAA   846-848           TAA   849-851           TGA   852-854           TAA   849-851           TGA   852-854           TGA   867-869           TGA   852-854           TGA   867-869           TAA   858-860           TGA   867-869           TGA   882-884           TGA   867-869           TGA   882-884           TAA   870-872           TGA   882-884           TAG   909-911           TGA   882-884           TAG   909-911           TAG   885-887           TAG   909-911           TGA   894-896           TAG   909-911           TAA   897-899           TAG   909-911           TAA   900-902           TAG   909-911           TGA   900-902           TAG   909-911           TAA   900-902           TAG   909-911           TAG   900-902           TAG   909-911           TGA   975-977           TAG   909-911           TGA   975-977           TAA   921-923           TGA   975-977           TGA   933-935           TGA   975-977           TAG   939-941           TGA   975-977           TGA   939-941           TGA   975-977           TAA   948-950           TGA   975-977           TAG   960-962           TGA   975-977           TAA    999-1001           TGA   975-977           TAA    999-1001           TAA   978-980           TAA    999-1001           TAG   981-983           TAA    999-1001           TAG   984-986           TAA    999-1001           TGA   1026-1028           TAA    999-1001           TGA   1026-1028           TGA   1002-1004           TGA   1026-1028           TAG   1005-1007           TGA   1026-1028           TAA   1011-1013           TGA   1026-1028           TGA   1017-1019           TGA   1026-1028           TAA   1020-1022           TGA   1026-1028           TAA   1035-1037           TGA   1026-1028           TAA   1035-1037           TAG   1032-1034           TAA   1035-1037           TGA   1032-1034           TAA   1035-1037           TAA   1038-1040           TAA   1035-1037           TAA   1038-1040           TAA   1074-1076           TAA   1038-1040           TAA   1074-1076           TAG   1041-1043           TAA   1074-1076           TAA   1044-1046           TAA   1074-1076           TAG   1062-1064           TAA   1074-1076           TAG   1065-1067           TAA   1074-1076           TAA   1092-1094           TAA   1074-1076           TAA   1092-1094           TAG   1077-1079           TAA   1092-1094           TAG   1080-1082           TAA   1092-1094           TGA   1080-1082           TAA   1092-1094           TAG   1089-1091           TAA   1092-1094           TAA   1104-1106           TAA   1092-1094           TAA   1104-1106           TGA   1095-1097           TAA   1104-1106           TAG   1101-1103           TAA   1104-1106           TGA   1101-1103           TAA   1104-1106           TGA   1107-1109           TAA   1104-1106           TGA   1107-1109           TAG   1110-1112           TGA   1107-1109           TAG   1110-1112           TGA   1152-1154           TAG   1110-1112           TGA   1152-1154           TAG   1122-1124           TGA   1152-1154           TGA   1128-1130           TGA   1152-1154           TAA   1131-1133           TGA   1152-1154           TAA   1134-1136           TGA   1152-1154           TGA   1140-1142           TGA   1152-1154           TAA   1146-1148           TGA   1152-1154           TGA   1164-1166           TGA   1152-1154           TGA   1164-1166           TAG   1161-1163           TGA   1164-1166           TGA   1161-1163           TGA   1164-1166           TAA   1182-1184           TGA   1164-1166           TAA   1182-1184           TAG   1167-1169           TAA   1182-1184           TAA   1170-1172           TAA   1182-1184           TGA   1173-1175           TAA   1182-1184           TAG   1176-1178           TAA   1182-1184           TGA   1176-1178           TAA   1182-1184           TAA   1179-1181           TAA   1182-1184           TAG   1212-1214           TAA   1182-1184           TAG   1212-1214           TAA   1188-1190           TAG   1212-1214           TAG   1197-1199           TAG   1212-1214           TGA   1197-1199           TAG   1212-1214           TGA   1203-1205           TAG   1212-1214           TAA   1206-1208           TAG   1212-1214           TGA   1221-1223           TAG   1212-1214           TGA   1221-1223           TGA   1215-1217           TGA   1221-1223           TAG   1248-1250           TGA   1221-1223           TAG   1248-1250           TGA   1224-1226           TAG   1248-1250           TAG   1233-1235           TAG   1248-1250           TGA   1233-1235           TAG   1248-1250           TAA   1245-1247           TAG   1248-1250           TAA   1266-1268           TAG   1248-1250           TAA   1266-1268           TAG   1251-1253           TAA   1266-1268           TAA   1260-1262           TAA   1266-1268           TGA   1269-1271           TAA   1266-1268           TGA   1269-1271           TGA   1287-1289           TGA   1269-1271           TGA   1287-1289           TAG   1272-1274           TGA   1287-1289           TGA   1272-1274           TGA   1287-1289           TAG   1281-1283           TGA   1287-1289           TAG   1284-1286           TGA   1287-1289           TGA   1290-1292           TGA   1287-1289           TGA   1290-1292           TGA   1305-1307           TGA   1290-1292           TGA   1305-1307           TGA   1308-1310           TGA   1305-1307           TGA   1308-1310           TGA   1317-1319           TGA   1308-1310           TGA   1317-1319           TGA   1329-1331           TGA   1317-1319           TGA   1329-1331           TGA   1323-1325           TGA   1329-1331           TGA   1350-1352           TGA   1329-1331           TGA   1350-1352           TAA   1335-1337           TGA   1350-1352           TAA   1341-1343           TGA   1350-1352           TGA   1371-1373           TGA   1350-1352           TGA   1371-1373           TGA   1359-1361           TGA   1371-1373           TAA   1368-1370           TGA   1371-1373           TGA   1380-1382           TGA   1371-1373           TGA   1380-1382           TGA   1377-1379           TGA   1380-1382           TGA   1422-1424           TGA   1380-1382           TGA   1422-1424           TAA   1383-1385           TGA   1422-1424           TGA   1383-1385           TGA   1422-1424           TAA   1383-1385           TGA   1422-1424           TAG   1383-1385           TGA   1422-1424           TGA   1398-1400           TGA   1422-1424           TAA   1401-1403           TGA   1422-1424           TGA   1407-1409           TGA   1422-1424           TAG   1419-1421           TGA   1422-1424           TGA   1431-1433           TGA   1422-1424           TGA   1431-1433           TAA   1446-1448           TGA   1431-1433           TAA   1446-1448           TAG   1443-1445           TAA   1446-1448           TGA   1443-1445           TAA   1446-1448           TGA   1452-1454           TAA   1446-1448           TGA   1452-1454           TAG   1449-1451           TGA   1452-1454           TAA   1482-1484           TGA   1452-1454           TAA   1482-1484           TAG   1455-1457           TAA   1482-1484           TAA   1467-1469           TAA   1482-1484           TGA   1476-1478           TAA   1482-1484           TAG   1479-1481           TAA   1482-1484           TGA   1488-1490           TAA   1482-1484           TGA   1488-1490           TGA   1554-1556           TGA   1488-1490           TGA   1554-1556           TGA   1491-1493           TGA   1554-1556           TAA   1494-1496           TGA   1554-1556           TAA   1506-1508           TGA   1554-1556           TAA   1512-1514           TGA   1554-1556           TGA   1512-1514           TGA   1554-1556           TAA   1512-1514           TGA   1554-1556           TAG   1512-1514           TGA   1554-1556           TAA   1518-1520           TGA   1554-1556           TAA   1521-1523           TGA   1554-1556           TAG   1527-1529           TGA   1554-1556           TAA   1536-1538           TGA   1554-1556           TAG   1542-1544           TGA   1554-1556           TGA   1584-1586           TGA   1554-1556           TGA   1584-1586           TAA   1557-1559           TGA   1584-1586           TAA   1620-1622           TGA   1584-1586           TAA   1620-1622           TGA   1602-1604           TAA   1620-1622           TAA   1617-1619           TAA   1620-1622           TAA   1632-1634           TAA   1620-1622           TAA   1632-1634           TAA   1626-1628           TAA   1632-1634           TGA   1662-1664           TAA   1632-1634           TGA   1662-1664           TAG   1635-1637           TGA   1662-1664           TAG   1638-1640           TGA   1662-1664           TGA   1707-1709           TGA   1662-1664           TGA   1707-1709           TGA   1665-1667           TGA   1707-1709           TAA   1674-1676           TGA   1707-1709           TAA   1677-1679           TGA   1707-1709           TGA   1683-1685           TGA   1707-1709           TAA   1698-1700           TGA   1707-1709           TAA   1728-1730           TGA   1707-1709           TAA   1728-1730           TAA   1716-1718           TAA   1728-1730           TAA   1767-1769           TAA   1728-1730           TAA   1767-1769           TGA   1737-1739           TAA   1767-1769           TAA   1743-1745           TAA   1767-1769           TAA   1758-1760           TAA   1767-1769           TAG   1770-1772           TAA   1767-1769           TAG   1770-1772           TGA   1779-1781           TAG   1770-1772           TGA   1779-1781           TAA   1785-1787           TGA   1779-1781           TAA   1785-1787           TAA   1782-1784           TAA   1785-1787           TGA   1797-1799           TAA   1785-1787           TGA   1797-1799           TAA   1791-1793           TGA   1797-1799           TGA   1812-1814           TGA   1797-1799           TGA   1812-1814           TAA   1809-1811           TGA   1812-1814           TAA   1824-1826           TGA   1812-1814           TAA   1824-1826           TAA   1815-1817           TAA   1824-1826           TAA   1818-1820           TAA   1824-1826           TGA   1872-1874           TAA   1824-1826           TGA   1872-1874           TGA   1833-1835           TGA   1872-1874           TGA   1842-1844           TGA   1872-1874           TAA   1845-1847           TGA   1872-1874           TGA   1848-1850           TGA   1872-1874           TAA   1860-1862           TGA   1872-1874           TAA   1866-1868           TGA   1872-1874           TAA   1938-1940           TGA   1872-1874           TAA   1938-1940           TAG   1881-1883           TAA   1938-1940           TAG   1884-1886           TAA   1938-1940           TAG   1887-1889           TAA   1938-1940           TAG   1893-1895           TAA   1938-1940           TAA   1896-1898           TAA   1938-1940           TGA   1902-1904           TAA   1938-1940           TGA   1908-1910           TAA   1938-1940           TAA   1914-1916           TAA   1938-1940           TAA   1923-1925           TAA   1938-1940           TAA   1929-1931           TAA   1938-1940           TAG   1947-1949           TAA   1938-1940           TAG   1947-1949           TAA   1941-1943           TAG   1947-1949           TAA   1944-1946           TAG   1947-1949           TGA   1989-1991           TAG   1947-1949           TGA   1989-1991           TAG   1953-1955           TGA   1989-1991           TAG   1956-1958           TGA   1989-1991           TAA   1959-1961           TGA   1989-1991           TAG   1971-1973           TGA   1989-1991           TAG   2004-2006           TGA   1989-1991           TAG   2004-2006           TAG   2001-2003           TAG   2004-2006           TAA   2022-2024           TAG   2004-2006           TAA   2022-2024           TAA   2007-2009           TAA   2022-2024           TAG   2013-2015           TAA   2022-2024           TGA   2031-2033           TAA   2022-2024           TGA   2031-2033           TAG   2025-2027           TGA   2031-2033           TGA   2025-2027           TGA   2031-2033           TGA   2043-2045           TGA   2031-2033           TGA   2043-2045           TAG   2046-2048           TGA   2043-2045           TAG   2046-2048           TAG   2055-2057           TAG   2046-2048           TAG   2055-2057           TAG   2049-2051           TAG   2055-2057           TGA   2049-2051           TAG   2055-2057           TGA   2061-2063           TAG   2055-2057           TGA   2061-2063           TAG   2058-2060           TGA   2061-2063           TAA   2133-2135           TGA   2061-2063           TAA   2133-2135           TGA   2064-2066           TAA   2133-2135           TAA   2070-2072           TAA   2133-2135           TAA   2073-2075           TAA   2133-2135           TAA   2076-2078           TAA   2133-2135           TAA   2079-2081           TAA   2133-2135           TAA   2082-2084           TAA   2133-2135           TGA   2082-2084           TAA   2133-2135           TAA   2082-2084           TAA   2133-2135           TAG   2082-2084           TAA   2133-2135           TAA   2085-2087           TAA   2133-2135           TAG   2100-2102           TAA   2133-2135           TAG   2106-2108           TAA   2133-2135           TAG   2109-2111           TAA   2133-2135           TAA   2112-2114           TAA   2133-2135           TGA   2127-2129           TAA   2133-2135           TAA   2163-2165           TAA   2133-2135           TAA   2163-2165           TGA   2136-2138           TAA   2163-2165           TAA   2154-2156           TAA   2163-2165           TAA   2157-2159           TAA   2163-2165           TAG   2160-2162           TAA   2163-2165           TGA   2175-2177           TAA   2163-2165           TGA   2175-2177           TAA   2166-2168           TGA   2175-2177           TAA   2172-2174           TGA   2175-2177           TAA   2187-2189           TGA   2175-2177           TAA   2187-2189           TAG   2184-2186           TAA   2187-2189           TGA   2196-2198           TAA   2187-2189           TGA   2196-2198           TAG   2190-2192           TGA   2196-2198           TGA   2202-2204           TGA   2196-2198           TGA   2202-2204           TAG   2199-2201           TGA   2202-2204           TAA   2250-2252           TGA   2202-2204           TAA   2250-2252           TGA   2214-2216           TAA   2250-2252           TAA   2220-2222           TAA   2250-2252           TAA   2229-2231           TAA   2250-2252           TGA   2268-2270           TAA   2250-2252           TGA   2268-2270           TAG   2253-2255           TGA   2268-2270           TGA   2253-2255           TGA   2268-2270           TAA   2259-2261           TGA   2268-2270           TAG   2265-2267           TGA   2268-2270           TAA   2274-2276           TGA   2268-2270           TAA   2274-2276           TAG   2292-2294           TAA   2274-2276           TAG   2292-2294           TGA   2277-2279           TAG   2292-2294           TAA   2286-2288           TAG   2292-2294           TAA   2334-2336           TAG   2292-2294           TAA   2334-2336           TAG   2301-2303           TAA   2334-2336           TGA   2304-2306           TAA   2334-2336           TGA   2307-2309           TAA   2334-2336           TAA   2310-2312           TAA   2334-2336           TGA   2313-2315           TAA   2334-2336           TGA   2316-2318           TAA   2334-2336           TAA   2319-2321           TAA   2334-2336           TGA   2325-2327           TAA   2334-2336           TAA   2343-2345           TAA   2334-2336           TAA   2343-2345           TAA   2346-2348           TAA   2343-2345           TAA   2346-2348           TGA   2352-2354           TAA   2346-2348           TGA   2352-2354           TGA   2400-2402           TGA   2352-2354           TGA   2400-2402           TGA   2355-2357           TGA   2400-2402           TAA   2361-2363           TGA   2400-2402           TGA   2364-2366           TGA   2400-2402           TAG   2376-2378           TGA   2400-2402           TGA   2382-2384           TGA   2400-2402           TAG   2385-2387           TGA   2400-2402           TAG   2418-2420           TGA   2400-2402           TAG   2418-2420           TAG   2403-2405           TAG   2418-2420           TGA   2412-2414           TAG   2418-2420           TAG   2415-2417           TAG   2418-2420           TGA   2445-2447           TAG   2418-2420           TGA   2445-2447           TAG   2421-2423           TGA   2445-2447           TAG   2484-2486           TGA   2445-2447           TAG   2484-2486           TAA   2448-2450           TAG   2484-2486           TGA   2448-2450           TAG   2484-2486           TAA   2448-2450           TAG   2484-2486           TAG   2448-2450           TAG   2484-2486           TGA   2460-2462           TAG   2484-2486           TAG   2463-2465           TAG   2484-2486           TGA   2478-2480           TAG   2484-2486           TAA   2517-2519           TAG   2484-2486           TAA   2517-2519           TAA   2496-2498           TAA   2517-2519           TAA   2502-2504           TAA   2517-2519           TGA   2508-2510           TAA   2517-2519           TAA   2514-2516           TAA   2517-2519           TGA   2544-2546           TAA   2517-2519           TGA   2544-2546           TAG   2520-2522           TGA   2544-2546           TGA   2520-2522           TGA   2544-2546           TAG   2526-2528           TGA   2544-2546           TAG   2532-2534           TGA   2544-2546           TGA   2532-2534           TGA   2544-2546           TAA   2583-2585           TGA   2544-2546           TAA   2583-2585           TAA   2547-2549           TAA   2583-2585           TAA   2553-2555           TAA   2583-2585           TAG   2571-2573           TAA   2583-2585           TGA   2571-2573           TAA   2583-2585           TAA   2577-2579           TAA   2583-2585           TGA   2580-2582           TAA   2583-2585           TAG   2586-2588           TAA   2583-2585           TAG   2586-2588           TGA   2592-2594           TAG   2586-2588           TGA   2592-2594           TAA   2589-2591           TGA   2592-2594           TAA   2607-2609           TGA   2592-2594           TAA   2607-2609           TGA   2598-2600           TAA   2607-2609           TGA   2625-2627           TAA   2607-2609           TGA   2625-2627           TAA   2610-2612           TGA   2625-2627           TGA   2610-2612           TGA   2625-2627           TAA   2610-2612           TGA   2625-2627           TAG   2610-2612           TGA   2625-2627           TAA   2631-2633           TGA   2625-2627           TAA   2631-2633           TGA   2670-2672           TAA   2631-2633           TGA   2670-2672           TAG   2637-2639           TGA   2670-2672           TGA   2643-2645           TGA   2670-2672           TAG   2649-2651           TGA   2670-2672           TGA   2655-2657           TGA   2670-2672           TGA   2661-2663           TGA   2670-2672           TGA   2664-2666           TGA   2670-2672           TAG   2667-2669           TGA   2670-2672           TGA   2676-2678           TGA   2670-2672           TGA   2676-2678           TGA   2823-2825           TGA   2676-2678           TGA   2823-2825           TAA   2685-2687           TGA   2823-2825           TGA   2685-2687           TGA   2823-2825           TAA   2685-2687           TGA   2823-2825           TAG   2685-2687           TGA   2823-2825           TAA   2694-2696           TGA   2823-2825           TAA   2703-2705           TGA   2823-2825           TAA   2712-2714           TGA   2823-2825           TAA   2739-2741           TGA   2823-2825           TAA   2748-2750           TGA   2823-2825           TGA   2754-2756           TGA   2823-2825           TGA   2757-2759           TGA   2823-2825           TGA   2760-2762           TGA   2823-2825           TAG   2763-2765           TGA   2823-2825           TGA   2763-2765           TGA   2823-2825           TAA   2796-2798           TGA   2823-2825           TAA   2799-2801           TGA   2823-2825           TAG   2805-2807           TGA   2823-2825           TAA   2811-2813           TGA   2823-2825           TGA   2829-2831           TGA   2823-2825           TGA   2829-2831           TAG   2826-2828           TGA   2829-2831           TGA   2826-2828           TGA   2829-2831           TGA   2859-2861           TGA   2829-2831           TGA   2859-2861           TAA   2835-2837           TGA   2859-2861           TGA   2838-2840           TGA   2859-2861           TGA   2841-2843           TGA   2859-2861           TAA   2844-2846           TGA   2859-2861           TAA   2853-2855           TGA   2859-2861           TAA   2856-2858           TGA   2859-2861           TAA   2865-2867           TGA   2859-2861           TAA   2865-2867           TAA   2889-2891           TAA   2865-2867           TAA   2889-2891           TAA   2871-2873           TAA   2889-2891           TAA   2928-2930           TAA   2889-2891           TAA   2928-2930           TAA   2922-2924           TAA   2928-2930           TGA   2925-2927           TAA   2928-2930           TGA   2937-2939           TAA   2928-2930           TGA   2937-2939           TAA   2940-2942           TGA   2937-2939           TAA   2940-2942           TAG   2952-2954           TAA   2940-2942           TAG   2952-2954           TAA   2946-2948           TAG   2952-2954           TAG   2949-2951           TAG   2952-2954           TGA   2949-2951           TAG   2952-2954           TAG   2970-2972           TAG   2952-2954           TAG   2970-2972           TAA   2958-2960           TAG   2970-2972           TAA   3027-3029           TAG   2970-2972           TAA   3027-3029           TAG   2976-2978           TAA   3027-3029           TGA   2976-2978           TAA   3027-3029           TAG   2994-2996           TAA   3027-3029           TAA   3000-3002           TAA   3027-3029           TGA   3003-3005           TAA   3027-3029           TAA   3024-3026           TAA   3027-3029           TAA   3090-3092           TAA   3027-3029           TAA   3090-3092           TAA   3045-3047           TAA   3090-3092           TAA   3051-3053           TAA   3090-3092           TGA   3051-3053           TAA   3090-3092           TAA   3051-3053           TAA   3090-3092           TAG   3051-3053           TAA   3090-3092           TAA   3078-3080           TAA   3090-3092           TAA   3096-3098           TAA   3090-3092           TAA   3096-3098           TAA   3102-3104           TAA   3096-3098           TAA   3102-3104           TAG   3099-3101           TAA   3102-3104           TGA   3099-3101           TAA   3102-3104           TGA   3129-3131           TAA   3102-3104           TGA   3129-3131           TAA   3105-3107           TGA   3129-3131           TAA   3108-3110           TGA   3129-3131           TGA   3117-3119           TGA   3129-3131           TGA   3120-3122           TGA   3129-3131           TAA   3123-3125           TGA   3129-3131           TGA   3150-3152           TGA   3129-3131           TGA   3150-3152           TGA   3132-3134           TGA   3150-3152           TGA   3168-3170           TGA   3150-3152           TGA   3168-3170           TAG   3153-3155           TGA   3168-3170           TGA   3156-3158           TGA   3168-3170           TAA   3165-3167           TGA   3168-3170           TAG   3198-3200           TGA   3168-3170           TAG   3198-3200           TAA   3171-3173           TAG   3198-3200           TAG   3180-3182           TAG   3198-3200           TAG   3189-3191           TAG   3198-3200           TAA   3204-3206           TAG   3198-3200           TAA   3204-3206           TAA   3207-3209           TAA   3204-3206           TAA   3207-3209           TAG   3213-3215           TAA   3207-3209           TAG   3213-3215           TAA   3228-3230           TAG   3213-3215           TAA   3228-3230           TGA   3216-3218           TAA   3228-3230           TAA   3219-3221           TAA   3228-3230           TAA   3252-3254           TAA   3228-3230           TAA   3252-3254           TAG   3237-3239           TAA   3252-3254           TAG   3243-3245           TAA   3252-3254           TAA   3246-3248           TAA   3252-3254           TGA   3255-3257           TAA   3252-3254           TGA   3255-3257           TAA   3273-3275           TGA   3255-3257           TAA   3273-3275           TAG   3267-3269           TAA   3273-3275           TGA   3276-3278           TAA   3273-3275           TGA   3276-3278           TAA   3294-3296           TGA   3276-3278           TAA   3294-3296           TAG   3288-3290           TAA   3294-3296           TGA   3297-3299           TAA   3294-3296           TGA   3297-3299           TGA   3312-3314           TGA   3297-3299           TGA   3312-3314           TAG   3309-3311           TGA   3312-3314           TGA   3315-3317           TGA   3312-3314           TGA   3315-3317           TAG   3339-3341           TGA   3315-3317           TAG   3339-3341           TAA   3318-3320           TAG   3339-3341           TGA   3330-3332           TAG   3339-3341           TAG   3372-3374           TAG   3339-3341           TAG   3372-3374           TAA   3342-3344           TAG   3372-3374           TAG   3345-3347           TAG   3372-3374           TAA   3354-3356           TAG   3372-3374           TAA   3360-3362           TAG   3372-3374           TGA   3393-3395           TAG   3372-3374           TGA   3393-3395           TAA   3402-3404           TGA   3393-3395           TAA   3402-3404           TAA   3399-3401           TAA   3402-3404           TGA   3399-3401           TAA   3402-3404           TAA   3399-3401           TAA   3402-3404           TAG   3399-3401           TAA   3402-3404           TAA   3423-3425           TAA   3402-3404           TAA   3423-3425           TAG   3408-3410           TAA   3423-3425           TAG   3420-3422           TAA   3423-3425           TAA   3429-3431           TAA   3423-3425           TAA   3429-3431           TAG   3426-3428           TAA   3429-3431           TGA   3426-3428           TAA   3429-3431           TGA   3438-3440           TAA   3429-3431           TGA   3438-3440           TGA   3459-3461           TGA   3438-3440           TGA   3459-3461           TAA   3444-3446           TGA   3459-3461           TAA   3447-3449           TGA   3459-3461           TGA   3453-3455           TGA   3459-3461           TAA   3456-3458           TGA   3459-3461           TGA   3456-3458           TGA   3459-3461           TAA   3456-3458           TGA   3459-3461           TAG   3456-3458           TGA   3459-3461           TAA   3480-3482           TGA   3459-3461           TAA   3480-3482           TGA   3462-3464           TAA   3480-3482           TAA   3513-3515           TAA   3480-3482           TAA   3513-3515           TGA   3486-3488           TAA   3513-3515           TAA   3498-3500           TAA   3513-3515           TGA   3498-3500           TAA   3513-3515           TAA   3498-3500           TAA   3513-3515           TAG   3498-3500           TAA   3513-3515           TGA   3510-3512           TAA   3513-3515           TAG   3537-3539           TAA   3513-3515           TAG   3537-3539           TGA   3519-3521           TAG   3537-3539           TAG   3534-3536           TAG   3537-3539           TGA   3561-3563           TAG   3537-3539           TGA   3561-3563           TAG   3555-3557           TGA   3561-3563           TGA   3555-3557           TGA   3561-3563           TGA   3570-3572           TGA   3561-3563           TGA   3570-3572           TGA   3573-3575           TGA   3570-3572           TGA   3573-3575           TGA   3585-3587           TGA   3573-3575           TGA   3585-3587           TGA   3582-3584           TGA   3585-3587           TGA   3591-3593           TGA   3585-3587           TGA   3591-3593           TAG   3609-3611           TGA   3591-3593           TAG   3609-3611           TAA   3597-3599           TAG   3609-3611           TGA   3600-3602           TAG   3609-3611           TGA   3603-3605           TAG   3609-3611           TGA   3618-3620           TAG   3609-3611           TGA   3618-3620           TGA   3624-3626           TGA   3618-3620           TGA   3624-3626           TAA   3621-3623           TGA   3624-3626           TAA   3630-3632           TGA   3624-3626           TAA   3630-3632           TAG   3651-3653           TAA   3630-3632           TAG   3651-3653           TGA   3633-3635           TAG   3651-3653           TAG   3636-3638           TAG   3651-3653           TAG   3678-3680           TAG   3651-3653           TAG   3678-3680           TAA   3654-3656           TAG   3678-3680           TAG   3657-3659           TAG   3678-3680           TAG   3666-3668           TAG   3678-3680           TGA   3672-3674           TAG   3678-3680           TAG   3690-3692           TAG   3678-3680           TAG   3690-3692           TAG   3681-3683           TAG   3690-3692           TAG   3684-3686           TAG   3690-3692           TAG   3771-3773           TAG   3690-3692           TAG   3771-3773           TAA   3723-3725           TAG   3771-3773           TGA   3723-3725           TAG   3771-3773           TAA   3723-3725           TAG   3771-3773           TAG   3723-3725           TAG   3771-3773           TAG   3729-3731           TAG   3771-3773           TAA   3738-3740           TAG   3771-3773           TAA   3741-3743           TAG   3771-3773           TGA   3747-3749           TAG   3771-3773           TGA   3756-3758           TAG   3771-3773           TGA   3759-3761           TAG   3771-3773           TAA   3762-3764           TAG   3771-3773           TGA   3774-3776           TAG   3771-3773           TGA   3774-3776           TGA   3780-3782           TGA   3774-3776           TGA   3780-3782           TGA   3777-3779           TGA   3780-3782           TAA   3816-3818           TGA   3780-3782           TAA   3816-3818           TGA   3783-3785           TAA   3816-3818           TAG   3792-3794           TAA   3816-3818           TGA   3792-3794           TAA   3816-3818           TAG   3846-3848           TAA   3816-3818           TAG   3846-3848           TAA   3822-3824           TAG   3846-3848           TAA   3825-3827           TAG   3846-3848           TAG   3852-3854           TAG   3846-3848           TAG   3852-3854           TAA   3879-3881           TAG   3852-3854           TAA   3879-3881           TGA   3867-3869           TAA   3879-3881           TAG   3870-3872           TAA   3879-3881           TGA   3870-3872           TAA   3879-3881           TAG   3915-3917           TAA   3879-3881           TAG   3915-3917           TAA   3882-3884           TAG   3915-3917           TGA   3888-3890           TAG   3915-3917           TGA   3891-3893           TAG   3915-3917           TAA   3894-3896           TAG   3915-3917           TAA   3909-3911           TAG   3915-3917           TAA   3912-3914           TAG   3915-3917           TGA   3924-3926           TAG   3915-3917           TGA   3924-3926           TAA   3921-3923           TGA   3924-3926           TAA   3933-3935           TGA   3924-3926           TAA   3933-3935           TAG   3927-3929           TAA   3933-3935           TGA   3927-3929           TAA   3933-3935           TAG   3930-3932           TAA   3933-3935           TAG   3975-3977           TAA   3933-3935           TAG   3975-3977           TAA   3951-3953           TAG   3975-3977           TGA   3963-3965           TAG   3975-3977           TGA   3978-3980           TAG   3975-3977           TGA   3978-3980           TAG   3999-4001           TGA   3978-3980           TAG   3999-4001           TGA   3981-3983           TAG   3999-4001           TAA   3987-3989           TAG   3999-4001           TAG   3990-3992           TAG   3999-4001           TGA   3990-3992           TAG   3999-4001           TGA   4023-4025           TAG   3999-4001           TGA   4023-4025           TAG   4017-4019           TGA   4023-4025           TGA   4017-4019           TGA   4023-4025           TAG   4020-4022           TGA   4023-4025           TGA   4104-4106           TGA   4023-4025           TGA   4104-4106           TGA   4029-4031           TGA   4104-4106           TGA   4032-4034           TGA   4104-4106           TAA   4044-4046           TGA   4104-4106           TAA   4050-4052           TGA   4104-4106           TGA   4059-4061           TGA   4104-4106           TAA   4083-4085           TGA   4104-4106           TAG   4092-4094           TGA   4104-4106           TGA   4128-4130           TGA   4104-4106           TGA   4128-4130           TAG   4107-4109           TGA   4128-4130           TAG   4125-4127           TGA   4128-4130           TGA   4149-4151           TGA   4128-4130           TGA   4149-4151           TAA   4131-4133           TGA   4149-4151           TGA   4134-4136           TGA   4149-4151           TGA   4146-4148           TGA   4149-4151           TGA   4152-4154           TGA   4149-4151           TGA   4152-4154           TAA   4182-4184           TGA   4152-4154           TAA   4182-4184           TGA   4155-4157           TAA   4182-4184           TAG   4158-4160           TAA   4182-4184           TGA   4173-4175           TAA   4182-4184           TGA   4176-4178           TAA   4182-4184           TAA   4179-4181           TAA   4182-4184           TGA   4218-4220           TAA   4182-4184           TGA   4218-4220           TGA   4188-4190           TGA   4218-4220           TGA   4191-4193           TGA   4218-4220           TAG   4197-4199           TGA   4218-4220           TGA   4203-4205           TGA   4218-4220           TAA   4209-4211           TGA   4218-4220           TGA   4236-4238           TGA   4218-4220           TGA   4236-4238           TAG   4233-4235           TGA   4236-4238           TGA   4233-4235           TGA   4236-4238           TGA   4242-4244           TGA   4236-4238           TGA   4242-4244           TAG   4239-4241           TGA   4242-4244           TGA   4257-4259           TGA   4242-4244           TGA   4257-4259           TAG   4248-4250           TGA   4257-4259           TGA   4287-4289           TGA   4257-4259           TGA   4287-4289           TGA   4260-4262           TGA   4287-4289           TAG   4263-4265           TGA   4287-4289           TGA   4263-4265           TGA   4287-4289           TAG   4284-4286           TGA   4287-4289           TAA   4326-4328           TGA   4287-4289           TAA   4326-4328           TAG   4308-4310           TAA   4326-4328           TGA   4311-4313           TAA   4326-4328           TGA   4356-4358           TAA   4326-4328           TGA   4356-4358           TAA   4335-4337           TGA   4356-4358           TGA   4347-4349           TGA   4356-4358           TAA   4398-4400           TGA   4356-4358           TAA   4398-4400           TGA   4362-4364           TAA   4398-4400           TGA   4374-4376           TAA   4398-4400           TAG   4386-4388           TAA   4398-4400           TGA   4422-4424           TAA   4398-4400           TGA   4422-4424           TAG   4401-4403           TGA   4422-4424           TAA   4404-4406           TGA   4422-4424           TGA   4404-4406           TGA   4422-4424           TAA   4404-4406           TGA   4422-4424           TAG   4404-4406           TGA   4422-4424           TAG   4419-4421           TGA   4422-4424           TGA   4437-4439           TGA   4422-4424           TGA   4437-4439           TAG   4500-4502           TGA   4437-4439           TAG   4500-4502           TGA   4440-4442           TAG   4500-4502           TAA   4449-4451           TAG   4500-4502           TGA   4455-4457           TAG   4500-4502           TAG   4461-4463           TAG   4500-4502           TGA   4470-4472           TAG   4500-4502           TAA   4473-4475           TAG   4500-4502           TAA   4494-4496           TAG   4500-4502           TAG   4497-4499           TAG   4500-4502           TGA   4503-4505           TAG   4500-4502           TGA   4503-4505           TGA   4542-4544           TGA   4503-4505           TGA   4542-4544           TAA   4506-4508           TGA   4542-4544           TGA   4506-4508           TGA   4542-4544           TAA   4506-4508           TGA   4542-4544           TAG   4506-4508           TGA   4542-4544           TAG   4515-4517           TGA   4542-4544           TAA   4521-4523           TGA   4542-4544           TGA   4527-4529           TGA   4542-4544           TGA   4551-4553           TGA   4542-4544           TGA   4551-4553           TAA   4545-4547           TGA   4551-4553           TAG   4566-4568           TGA   4551-4553           TAG   4566-4568           TGA   4563-4565           TAG   4566-4568           TAA   4578-4580           TAG   4566-4568           TAA   4578-4580           TAG   4575-4577           TAA   4578-4580           TAA   4584-4586           TAA   4578-4580           TAA   4584-4586           TAA   4581-4583           TAA   4584-4586           TAA   4617-4619           TAA   4584-4586           TAA   4617-4619           TGA   4587-4589           TAA   4617-4619           TGA   4599-4601           TAA   4617-4619           TAG   4602-4604           TAA   4617-4619           TGA   4635-4637           TAA   4617-4619           TGA   4635-4637           TAG   4620-4622           TGA   4635-4637           TGA   4620-4622           TGA   4635-4637           TGA   4632-4634           TGA   4635-4637           TAG   4638-4640           TGA   4635-4637           TAG   4638-4640           TAG   4677-4679           TAG   4638-4640           TAG   4677-4679           TAG   4641-4643           TAG   4677-4679           TGA   4641-4643           TAG   4677-4679           TAA   4644-4646           TAG   4677-4679           TGA   4644-4646           TAG   4677-4679           TAA   4644-4646           TAG   4677-4679           TAG   4644-4646           TAG   4677-4679           TAG   4653-4655           TAG   4677-4679           TAG   4656-4658           TAG   4677-4679           TGA   4656-4658           TAG   4677-4679           TAG   4665-4667           TAG   4677-4679           TAA   4674-4676           TAG   4677-4679           TAA   4707-4709           TAG   4677-4679           TAA   4707-4709           TAA   4680-4682           TAA   4707-4709           TAA   4683-4685           TAA   4707-4709           TGA   4683-4685           TAA   4707-4709           TAA   4683-4685           TAA   4707-4709           TAG   4683-4685           TAA   4707-4709           TGA   4695-4697           TAA   4707-4709           TGA   4698-4700           TAA   4707-4709           TGA   4716-4718           TAA   4707-4709           TGA   4716-4718           TGA   4836-4838           TGA   4716-4718           TGA   4836-4838           TGA   4722-4724           TGA   4836-4838           TGA   4725-4727           TGA   4836-4838           TGA   4737-4739           TGA   4836-4838           TGA   4740-4742           TGA   4836-4838           TGA   4755-4757           TGA   4836-4838           TGA   4764-4766           TGA   4836-4838           TAA   4773-4775           TGA   4836-4838           TGA   4773-4775           TGA   4836-4838           TAA   4773-4775           TGA   4836-4838           TAG   4773-4775           TGA   4836-4838           TAG   4782-4784           TGA   4836-4838           TGA   4788-4790           TGA   4836-4838           TGA   4794-4796           TGA   4836-4838           TAA   4806-4808           TGA   4836-4838           TGA   4806-4808           TGA   4836-4838           TAA   4806-4808           TGA   4836-4838           TAG   4806-4808           TGA   4836-4838           TGA   4812-4814           TGA   4836-4838           TAG   4824-4826           TGA   4836-4838           TGA   4839-4841           TGA   4836-4838           TGA   4839-4841           TGA   4845-4847           TGA   4839-4841           TGA   4845-4847           TGA   4851-4853           TGA   4845-4847           TGA   4851-4853           TGA   4860-4862           TGA   4851-4853           TGA   4860-4862           TGA   4980-4982           TGA   4860-4862           TGA   4980-4982           TGA   4863-4865           TGA   4980-4982           TAG   4866-4868           TGA   4980-4982           TGA   4875-4877           TGA   4980-4982           TAA   4893-4895           TGA   4980-4982           TAA   4920-4922           TGA   4980-4982           TAA   4935-4937           TGA   4980-4982           TGA   4944-4946           TGA   4980-4982           TAA   4995-4997           TGA   4980-4982           TAA   4995-4997           TAA   4992-4994           TAA   4995-4997           TGA   4992-4994           TAA   4995-4997           TAA   4992-4994           TAA   4995-4997           TAG   4992-4994           TAA   4995-4997           TAA   5151-5153           TAA   4995-4997           TAA   5151-5153           TGA   5004-5006           TAA   5151-5153           TGA   5007-5009           TAA   5151-5153           TAG   5010-5012           TAA   5151-5153           TAG   5016-5018           TAA   5151-5153           TAG   5019-5021           TAA   5151-5153           TGA   5022-5024           TAA   5151-5153           TAA   5025-5027           TAA   5151-5153           TGA   5031-5033           TAA   5151-5153           TGA   5049-5051           TAA   5151-5153           TAG   5052-5054           TAA   5151-5153           TAA   5058-5060           TAA   5151-5153           TAA   5061-5063           TAA   5151-5153           TAG   5064-5066           TAA   5151-5153           TGA   5097-5099           TAA   5151-5153           TGA   5100-5102           TAA   5151-5153           TAA   5115-5117           TAA   5151-5153           TGA   5115-5117           TAA   5151-5153           TAA   5115-5117           TAA   5151-5153           TAG   5115-5117           TAA   5151-5153           TAA   5118-5120           TAA   5151-5153           TAG   5127-5129           TAA   5151-5153           TAA   5130-5132           TAA   5151-5153           TGA   5163-5165           TAA   5151-5153           TGA   5163-5165           TGA   5199-5201           TGA   5163-5165           TGA   5199-5201           TGA   5166-5168           TGA   5199-5201           TAA   5187-5189           TGA   5199-5201           TGA   5193-5195           TGA   5199-5201           TGA   5211-5213           TGA   5199-5201           TGA   5211-5213           TAG   5208-5210           TGA   5211-5213           TGA   5208-5210           TGA   5211-5213           TAG   5262-5264           TGA   5211-5213           TAG   5262-5264           TAA   5223-5225           TAG   5262-5264           TAA   5226-5228           TAG   5262-5264           TGA   5226-5228           TAG   5262-5264           TAA   5226-5228           TAG   5262-5264           TAG   5226-5228           TAG   5262-5264           TAA   5250-5252           TAG   5262-5264           TAG   5253-5255           TAG   5262-5264           TGA   5253-5255           TAG   5262-5264           TAA   5289-5291           TAG   5262-5264           TAA   5289-5291           TAA   5265-5267           TAA   5289-5291           TGA   5265-5267           TAA   5289-5291           TAA   5265-5267           TAA   5289-5291           TAG   5265-5267           TAA   5289-5291           TAG   5271-5273           TAA   5289-5291           TGA   5271-5273           TAA   5289-5291           TGA   5310-5312           TAA   5289-5291           TGA   5310-5312           TGA   5292-5294           TGA   5310-5312           TAG   5295-5297           TGA   5310-5312           TAA   5298-5300           TGA   5310-5312           TAA   5307-5309           TGA   5310-5312           TGA   5316-5318           TGA   5310-5312           TGA   5316-5318           TGA   5322-5324           TGA   5316-5318           TGA   5322-5324           TGA   5604-5606           TGA   5322-5324           TGA   5604-5606           TAG   5328-5330           TGA   5604-5606           TGA   5334-5336           TGA   5604-5606           TAA   5343-5345           TGA   5604-5606           TAG   5349-5351           TGA   5604-5606           TAA   5352-5354           TGA   5604-5606           TAA   5367-5369           TGA   5604-5606           TAG   5376-5378           TGA   5604-5606           TGA   5379-5381           TGA   5604-5606           TGA   5388-5390           TGA   5604-5606           TAG   5391-5393           TGA   5604-5606           TAA   5394-5396           TGA   5604-5606           TAG   5403-5405           TGA   5604-5606           TGA   5412-5414           TGA   5604-5606           TAG   5418-5420           TGA   5604-5606           TGA   5418-5420           TGA   5604-5606           TAG   5421-5423           TGA   5604-5606           TGA   5421-5423           TGA   5604-5606           TAA   5424-5426           TGA   5604-5606           TGA   5424-5426           TGA   5604-5606           TAA   5424-5426           TGA   5604-5606           TAG   5424-5426           TGA   5604-5606           TAA   5439-5441           TGA   5604-5606           TGA   5451-5453           TGA   5604-5606           TGA   5460-5462           TGA   5604-5606           TAG   5463-5465           TGA   5604-5606           TGA   5463-5465           TGA   5604-5606           TAG   5478-5480           TGA   5604-5606           TGA   5478-5480           TGA   5604-5606           TAA   5496-5498           TGA   5604-5606           TGA   5499-5501           TGA   5604-5606           TGA   5556-5558           TGA   5604-5606           TAG   5562-5564           TGA   5604-5606           TGA   5562-5564           TGA   5604-5606           TGA   5568-5570           TGA   5604-5606           TGA   5571-5573           TGA   5604-5606           TAA   5574-5576           TGA   5604-5606           TAG   5601-5603           TGA   5604-5606           TGA   5601-5603           TGA   5604-5606           TGA   5625-5627           TGA   5628-5630           TGA   5637-5639           TAG   5640-5642           TAG   5652-5654           TGA   5658-5660           TGA   5664-5666           TGA   5670-5672           TAG   5676-5678           TAG   5700-5702           TAG   5706-5708                      
 
       [0046] Two base insertions of the present invention form stop codons as indicated in the following TABLE 7. The formed in-frame stop codon and the location are provided. Any expressed protein from BRCA1 genes with these types of mutations should be truncated accordingly. It should be recognized that the present invention includes insertions of 3n+2 bases, where n is an integer greater than zero and less than 1861. These larger insertions mutations have stop codons at nucleotide numbers corresponding to the listed stop codon at the nucleotide number listed. The corresponding nucleotide numbers of the stop codons will be 3n nucleotides larger than those listed.  
               TABLE 7                          Two Base Insertions                             Codon Formed   Nucleotide Number                       TAG   123-125           TAA   126-128           TAG   126-128           TGA   126-128           TAA   129-131           TAG   129-131           TGA   129-131           TAG   132-134           TAG   141-143           TAG   144-146           TAG   147-149           TAG   150-152           TAA   156-158           TAG   159-161           TAA   162-164           TAA   165-167           TAG   168-170           TAA   171-173           TAA   177-179           TGA   177-179           TAA   180-182           TAA   183-185           TAG   183-185           TGA   183-185           TAG   186-188           TAA   189-191           TAG   189-191           TGA   189-191           TAA   195-197           TAA   198-200           TAG   198-200           TGA   198-200           TAG   204-206           TAA   207-209           TAG   207-209           TGA   207-209           TAA   210-212           TGA   210-212           TAA   213-215           TAG   216-218           TAG   222-224           TAA   225-227           TAG   225-227           TGA   225-227           TAA   228-230           TAA   231-233           TAA   234-236           TAG   234-236           TGA   234-236           TAG   237-239           TAA   243-245           TAA   246-248           TAG   246-248           TGA   246-248           TAA   249-251           TAG   249-251           TGA   249-251           TAA   252-254           TAA   255-257           TAG   255-257           TGA   255-257           TAA   258-260           TAG   258-260           TGA   258-260           TAA   261-263           TAA   267-269           TGA   267-269           TAA   276-278           TAA   282-284           TGA   282-284           TAA   285-287           TGA   285-287           TAG   288-290           TAA   294-296           TAG   294-296           TGA   294-296           TAA   300-302           TAG   300-302           TGA   300-302           TAA   306-308           TAG   306-308           TGA   306-308           TAA   309-311           TAG   309-311           TGA   309-311           TAA   312-314           TAA   315-317           TGA   315-317           TAG   318-320           TAA   321-323           TAA   324-326           TAA   327-329           TAA   330-332           TAA   333-335           TGA   333-335           TAG   342-344           TAA   345-347           TAA   348-350           TAA   351-353           TGA   351-353           TAA   354-356           TAG   354-356           TGA   354-356           TAA   357-359           TAG   366-368           TAG   369-371           TAG   372-374           TAA   378-380           TAG   378-380           TGA   378-380           TAA   381-383           TGA   381-383           TAA   384-386           TAA   387-389           TAA   390-392           TAG   390-392           TGA   390-392           TAG   393-395           TAA   396-398           TAG   396-398           TGA   396-398           TAG   405-407           TAA   408-410           TAG   411-413           TAA   414-416           TAG   414-416           TGA   414-416           TAG   417-419           TAA   420-422           TAG   420-422           TGA   420-422           TAG   423-425           TAA   426-428           TAA   429-431           TAA   432-434           TAG   432-434           TGA   432-434           TAA   435-437           TAA   438-440           TAG   438-440           TGA   438-440           TAG   441-443           TAA   444-446           TAA   447-449           TAG   450-452           TAA   453-455           TAA   456-458           TAA   459-461           TAG   459-461           TGA   459-461           TAG   465-467           TAA   474-476           TAG   477-479           TAG   480-482           TAG   483-485           TAA   486-488           TAG   486-488           TGA   486-488           TAA   489-491           TAA   492-494           TAA   498-500           TAA   501-503           TAG   504-506           TAA   507-509           TAG   507-509           TGA   507-509           TAA   510-512           TAA   513-515           TAG   519-521           TAA   522-524           TAA   525-527           TAA   537-539           TGA   537-539           TAG   540-542           TAG   546-548           TAA   549-551           TAA   555-557           TAG   555-557           TGA   555-557           TAA   558-560           TAG   558-560           TGA   558-560           TAG   564-566           TAA   567-569           TAA   570-572           TAA   576-578           TAG   579-581           TAA   588-590           TAG   588-590           TGA   588-590           TAA   591-593           TAG   597-599           TAA   600-602           TAG   603-605           TAA   606-608           TGA   606-608           TAA   609-611           TAA   615-617           TGA   615-617           TAA   618-620           TGA   618-620           TAA   621-623           TAA   630-632           TGA   630-632           TAA   642-644           TAA   645-647           TGA   645-647           TAA   648-650           TAG   648-650           TGA   648-650           TAG   651-653           TAA   654-656           TAG   654-656           TGA   654-656           TAA   657-659           TAG   660-662           TAA   663-665           TAG   663-665           TGA   663-665           TAG   666-668           TAA   669-671           TAG   669-671           TGA   669-671           TAG   672-674           TAA   675-677           TAG   675-677           TGA   675-677           TAA   678-680           TAG   678-680           TGA   678-680           TAG   681-683           TAG   684-686           TAA   687-689           TAG   690-692           TAA   693-695           TAA   696-698           TAG   699-701           TAA   702-704           TAA   705-707           TAG   705-707           TGA   705-707           TAA   708-710           TAG   708-710           TGA   708-710           TAA   711-713           TAG   714-716           TAG   717-719           TAG   720-722           TAG   726-728           TAA   729-731           TAG   729-731           TGA   729-731           TAA   732-734           TAG   732-734           TGA   732-734           TAA   738-740           TAA   741-743           TAG   750-752           TAA   753-755           TAA   756-758           TAG   759-761           TAG   762-764           TAA   765-767           TAA   768-770           TAA   771-773           TAG   771-773           TGA   771-773           TAG   774-776           TAA   777-779           TAG   777-779           TGA   777-779           TAG   780-782           TAA   783-785           TAA   786-788           TAG   789-791           TAG   792-794           TAA   795-797           TAG   795-797           TGA   795-797           TAG   798-800           TAA   801-803           TAG   801-803           TGA   801-803           TAA   804-806           TAG   804-806           TGA   804-806           TAG   807-809           TAA   810-812           TGA   810-812           TAG   813-815           TAG   816-818           TAA   819-821           TAA   822-824           TAA   825-827           TAG   828-830           TAA   843-845           TAA   846-848           TAA   849-851           TAG   852-854           TAA   855-857           TAG   855-857           TGA   855-857           TAA   858-860           TGA   858-860           TAA   861-863           TAA   864-866           TAG   867-869           TAA   870-872           TGA   870-872           TAG   876-878           TAG   879-881           TAG   882-884           TAA   885-887           TGA   885-887           TAG   894-896           TAA   897-899           TAA   900-902           TAG   900-902           TGA   900-902           TAG   906-908           TAA   909-911           TAA   912-914           TAG   912-914           TGA   912-914           TAG   915-917           TAA   918-920           TAG   918-920           TGA   918-920           TAA   921-923           TAA   924-926           TAG   924-926           TGA   924-926           TAG   930-932           TAG   933-935           TAA   939-941           TAG   939-941           TGA   939-941           TAG   942-944           TAA   945-947           TAA   948-950           TAA   951-953           TAG   957-959           TAA   960-962           TAA   963-965           TAG   963-965           TGA   963-965           TAA   966-968           TAG   966-968           TGA   966-968           TAG   975-977           TAA   978-980           TGA   978-980           TAA   981-983           TAA   984-986           TAA   987-989           TAG   987-989           TGA   987-989           TAA   990-992           TAG   990-992           TGA   990-992           TAA   996-998           TAA    999-1001           TAG   1002-1004           TAA   1005-1007           TAA   1008-1010           TAA   1011-1013           TGA   1011-1013           TAG   1014-1016           TAG   1017-1019           TAA   1020-1022           TAG   1023-1025           TAG   1026-1028           TAA   1029-1031           TAG   1029-1031           TGA   1029-1031           TAA   1032-1034           TAG   1032-1034           TGA   1032-1034           TAA   1035-1037           TAA   1038-1040           TAA   1041-1043           TAA   1044-1046           TAG   1053-1055           TAA   1056-1058           TAG   1056-1058           TGA   1056-1058           TAG   1059-1061           TAA   1062-1064           TAA   1065-1067           TGA   1065-1067           TAA   1074-1076           TAA   1077-1079           TAA   1080-1082           TAG   1080-1082           TGA   1080-1082           TAG   1083-1085           TAG   1086-1088           TAA   1089-1091           TAA   1092-1094           TAG   1095-1097           TAA   1098-1100           TAA   1101-1103           TAG   1101-1103           TGA   1101-1103           TAA   1104-1106           TAG   1107-1109           TAA   1110-1112           TAA   1116-1118           TGA   1116-1118           TAA   1122-1124           TAA   1125-1127           TAG   1128-1130           TAA   1131-1133           TAA   1134-1136           TAG   1137-1139           TAG   1140-1142           TAA   1146-1148           TGA   1146-1148           TAG   1149-1151           TAG   1152-1154           TAA   1161-1163           TAG   1161-1163           TGA   1161-1163           TAG   1164-1166           TAA   1167-1169           TGA   1167-1169           TAA   1170-1172           TAG   1173-1175           TAA   1176-1178           TAG   1176-1178           TGA   1176-1178           TAA   1179-1181           TGA   1179-1181           TAA   1182-1184           TAA   1188-1190           TGA   1188-1190           TAA   1197-1199           TAG   1197-1199           TGA   1197-1199           TAA   1200-1202           TAG   1200-1202           TGA   1200-1202           TAG   1203-1205           TAA   1206-1208           TGA   1206-1208           TAA   1212-1214           TAG   1215-1217           TAA   1218-1220           TAG   1221-1223           TAG   1224-1226           TAG   1227-1229           TAA   1233-1235           TAG   1233-1235           TGA   1233-1235           TAA   1236-1238           TGA   1236-1238           TAA   1239-1241           TAA   1245-1247           TAA   1248-1250           TAA   1251-1253           TAA   1254-1256           TAA   1260-1262           TGA   1260-1262           TAG   1263-1265           TAA   1266-1268           TAG   1269-1271           TAA   1272-1274           TAG   1272-1274           TGA   1272-1274           TAA   1275-1277           TAG   1275-1277           TGA   1275-1277           TAA   1278-1280           TAG   1278-1280           TGA   1278-1280           TAA   1281-1283           TAA   1284-1286           TAG   1287-1289           TAG   1290-1292           TAA   1296-1298           TAG   1296-1298           TGA   1296-1298           TAG   1299-1301           TAA   1302-1304           TAG   1302-1304           TGA   1302-1304           TAG   1305-1307           TAG   1308-1310           TAA   1311-1313           TAG   1311-1313           TGA   1311-1313           TAG   1317-1319           TAG   1320-1322           TAG   1323-1325           TAA   1326-1328           TAG   1326-1328           TGA   1326-1328           TAG   1329-1331           TAA   1332-1334           TAG   1332-1334           TGA   1332-1334           TAA   1335-1337           TAG   1338-1340           TAA   1341-1343           TAG   1344-1346           TAG   1347-1349           TAG   1350-1352           TAG   1353-1355           TAA   1356-1358           TAG   1356-1358           TGA   1356-1358           TAG   1359-1361           TAG   1362-1364           TAA   1368-1370           TAG   1371-1373           TAG   1374-1376           TAG   1377-1379           TAG   1380-1382           TAA   1383-1385           TAG   1383-1385           TGA   1383-1385           TAA   1386-1388           TAG   1386-1388           TGA   1386-1388           TAG   1389-1391           TAA   1392-1394           TAG   1392-1394           TGA   1392-1394           TAA   1395-1397           TAG   1395-1397           TGA   1395-1397           TAG   1398-1400           TAA   1401-1403           TGA   1401-1403           TAA   1404-1406           TAG   1407-1409           TAA   1410-1412           TAG   1410-1412           TGA   1410-1412           TAG   1416-1418           TAA   1419-1421           TAG   1422-1424           TAG   1431-1433           TAG   1434-1436           TAA   1437-1439           TAG   1437-1439           TGA   1437-1439           TAA   1440-1442           TAA   1443-1445           TAG   1443-1445           TGA   1443-1445           TAA   1446-1448           TAA   1449-1451           TAG   1452-1454           TAA   1455-1457           TAG   1458-1460           TAA   1464-1466           TAG   1464-1466           TGA   1464-1466           TAA   1467-1469           TAA   1470-1472           TAG   1470-1472           TGA   1470-1472           TAG   1473-1475           TAG   1476-1478           TAA   1479-1481           TGA   1479-1481           TAA   1482-1484           TAA   1485-1487           TAG   1488-1490           TAG   1491-1493           TAA   1494-1496           TAA   1497-1499           TAA   1500-1502           TAG   1500-1502           TGA   1500-1502           TAG   1503-1505           TAA   1506-1508           TGA   1506-1508           TAA   1509-1511           TAA   1512-1514           TAG   1512-1514           TGA   1512-1514           TAA   1518-1520           TGA   1518-1520           TAA   1521-1523           TGA   1521-1523           TAG   1524-1526           TAA   1527-1529           TAA   1536-1538           TAA   1539-1541           TAG   1539-1541           TGA   1539-1541           TAA   1542-1544           TAG   1548-1550           TAA   1551-1553           TAG   1554-1556           TAA   1557-1559           TAA   1563-1565           TAA   1566-1568           TAG   1569-1571           TAG   1572-1574           TAA   1575-1577           TAG   1575-1577           TGA   1575-1577           TAG   1578-1580           TAA   1581-1583           TAG   1584-1586           TAA   1593-1595           TGA   1593-1595           TAA   1596-1598           TAG   1602-1604           TAA   1614-1616           TAA   1617-1619           TAA   1620-1622           TAA   1623-1625           TAG   1623-1625           TGA   1623-1625           TAA   1626-1628           TAA   1632-1634           TAA   1635-1637           TAA   1638-1640           TGA   1638-1640           TAA   1644-1646           TAA   1647-1649           TAG   1647-1649           TGA   1647-1649           TAG   1650-1652           TAG   1662-1664           TAG   1665-1667           TAA   1668-1670           TAG   1668-1670           TGA   1668-1670           TAA   1671-1673           TAA   1674-1676           TAA   1677-1679           TGA   1677-1679           TAG   1680-1682           TAG   1683-1685           TAA   1686-1688           TAG   1686-1688           TGA   1686-1688           TAG   1689-1691           TAG   1692-1694           TAA   1698-1700           TAA   1701-1703           TGA   1701-1703           TAG   1707-1709           TAA   1710-1712           TAA   1713-1715           TGA   1713-1715           TAA   1716-1718           TAG   1722-1724           TAA   1725-1727           TAA   1728-1730           TAA   1734-1736           TAG   1737-1739           TAA   1743-1745           TGA   1743-1745           TAG   1746-1748           TAG   1752-1754           TAA   1755-1757           TGA   1755-1757           TAA   1758-1760           TGA   1758-1760           TAA   1761-1763           TAA   1764-1766           TAA   1767-1769           TAA   1770-1772           TAG   1773-1775           TAG   1779-1781           TAA   1782-1784           TGA   1782-1784           TAA   1785-1787           TAA   1788-1790           TAA   1791-1793           TAG   1794-1796           TAG   1797-1799           TAA   1800-1802           TAG   1800-1802           TGA   1800-1802           TAA   1803-1805           TAA   1809-1811           TGA   1809-1811           TAG   1812-1814           TAA   1815-1817           TGA   1815-1817           TAA   1818-1820           TAA   1824-1826           TAA   1830-1832           TAG   1833-1835           TAA   1836-1838           TAG   1836-1838           TGA   1836-1838           TAG   1842-1844           TAA   1845-1847           TAG   1848-1850           TAA   1851-1853           TAG   1851-1853           TGA   1851-1853           TAG   1854-1856           TAA   1857-1859           TAG   1857-1859           TGA   1857-1859           TAA   1860-1862           TAA   1863-1865           TAA   1866-1868           TGA   1866-1868           TAG   1869-1871           TAG   1872-1874           TAA   1878-1880           TAA   1881-1883           TAA   1884-1886           TAA   1887-1889           TAA   1890-1892           TAA   1893-1895           TAA   1896-1898           TAA   1899-1901           TAG   1902-1904           TAG   1908-1910           TAA   1911-1913           TAG   1911-1913           TGA   1911-1913           TAA   1914-1916           TAA   1917-1919           TAA   1923-1925           TAA   1926-1928           TAG   1926-1928           TGA   1926-1928           TAA   1929-1931           TAG   1932-1934           TAA   1938-1940           TAA   1941-1943           TAA   1944-1946           TGA   1944-1946           TAA   1947-1949           TGA   1953-1955           TAA   1953-1955           TGA   1953-1955           TAA   1956-1958           TGA   1956-1958           TAA   1959-1961           TGA   1959-1961           TAA   1962-1964           TAG   1962-1964           TGA   1962-1964           TAA   1965-1967           TAG   1965-1967           TGA   1965-1967           TAA   1968-1970           TAA   1971-1973           TAA   1977-1979           TAG   1983-1985           TAG   1989-1991           TAG   1995-1997           TAG   1998-2000           TAA   2001-2003           TAA   2004-2006           TAA   2007-2009           TAA   2013-2015           TAA   2022-2024           TAA   2025-2027           TAG   2025-2027           TGA   2025-2027           TAA   2028-2030           TAG   2031-2033           TAA   2034-2036           TAG   2034-2036           TGA   2034-2036           TAA   2040-2042           TAG   2043-2045           TAA   2046-2048           TAA   2049-2051           TAG   2049-2051           TGA   2049-2051           TAA   2052-2054           TAG   2052-2054           TGA   2052-2054           TAA   2055-2057           TAA   2058-2060           TAG   2061-2063           TAG   2064-2066           TAA   2067-2069           TGA   2067-2069           TAA   2070-2072           TAA   2073-2075           TGA   2073-2075           TAA   2076-2078           TAA   2079-2081           TAA   2082-2084           TAG   2082-2084           TGA   2082-2084           TAA   2085-2087           TAA   2091-2093           TAG   2097-2099           TAA   2100-2102           TAA   2106-2108           TAA   2109-2111           TAA   2112-2114           TAA   2124-2126           TAG   2127-2129           TAG   2130-2132           TAA   2133-2135           TAG   2136-2138           TAG   2142-2144           TAA   2145-2147           TAG   2148-2150           TAG   2151-2153           TAA   2154-2156           TAA   2157-2159           TGA   2157-2159           TAA   2160-2162           TGA   2160-2162           TAA   2163-2165           TAA   2166-2168           TAA   2172-2174           TAG   2175-2177           TAA   2181-2183           TGA   2181-2183           TAA   2184-2186           TAA   2187-2189           TAA   2190-2192           TAG   2196-2198           TAA   2199-2201           TAG   2202-2204           TAA   2205-2207           TAA   2208-2210           TAG   2208-2210           TGA   2208-2210           TAG   2214-2216           TAA   2220-2222           TGA   2220-2222           TAA   2223-2225           TAG   2223-2225           TGA   2223-2225           TAA   2226-2228           TAA   2229-2231           TAG   2232-2234           TAG   2238-2240           TAA   2241-2243           TAG   2241-2243           TGA   2241-2243           TAA   2244-2246           TAG   2244-2246           TGA   2244-2246           TAA   2247-2249           TAA   2250-2252           TAA   2253-2255           TAG   2253-2255           TGA   2253-2255           TAA   2256-2258           TAG   2256-2258           TGA   2256-2258           TAA   2259-2261           TAA   2262-2264           TAA   2265-2267           TAG   2268-2270           TAA   2274-2276           TAG   2277-2279           TAA   2280-2282           TAG   2280-2282           TGA   2280-2282           TAG   2283-2285           TAA   2286-2288           TAA   2292-2294           TAA   2301-2303           TAG   2304-2306           TAG   2307-2309           TAA   2310-2312           TAG   2313-2315           TAG   2316-2318           TAA   2319-2321           TGA   2319-2321           TAG   2325-2327           TAA   2328-2330           TAG   2331-2333           TAA   2334-2336           TAG   2337-2339           TAA   2340-2342           TAG   2340-2342           TGA   2340-2342           TAA   2343-2345           TAA   2346-2348           TAG   2349-2351           TAG   2352-2354           TAG   2355-2357           TAA   2361-2363           TAG   2364-2366           TAA   2370-2372           TAA   2373-2375           TAG   2373-2375           TGA   2373-2375           TAA   2376-2378           TAG   2379-2381           TAG   2382-2384           TAA   2385-2387           TAG   2388-2390           TAA   2391-2393           TAG   2391-2393           TGA   2391-2393           TAA   2397-2399           TAG   2400-2402           TAA   2403-2405           TAA   2406-2408           TAG   2406-2408           TGA   2406-2408           TAG   2409-2411           TAG   2412-2414           TAA   2415-2417           TGA   2415-2417           TAA   2418-2420           TAA   2421-2423           TAA   2424-2426           TAA   2427-2429           TAG   2427-2429           TGA   2427-2429           TAG   2433-2435           TAG   2439-2441           TAA   2442-2444           TAG   2445-2447           TAA   2448-2450           TAG   2448-2450           TGA   2448-2450           TAG   2451-2453           TAA   2454-2456           TAG   2460-2462           TAA   2463-2465           TAA   2466-2468           TAA   2469-2471           TAG   2469-2471           TGA   2469-2471           TAA   2472-2474           TAG   2472-2474           TGA   2472-2474           TAG   2478-2480           TAG   2481-2483           TAA   2484-2486           TAA   2487-2489           TAG   2493-2495           TAA   2496-2498           TGA   2496-2498           TAG   2499-2501           TAA   2502-2504           TAA   2505-2507           TAG   2508-2510           TAA   2514-2516           TAA   2517-2519           TAA   2520-2522           TAG   2520-2522           TGA   2520-2522           TAG   2523-2525           TAA   2526-2528           TGA   2526-2528           TAA   2532-2534           TAG   2532-2534           TGA   2532-2534           TAG   2535-2537           TAG   2538-2540           TAA   2541-2543           TAG   2541-2543           TGA   2541-2543           TAG   2544-2546           TAA   2547-2549           TAA   2553-2555           TAG   2556-2558           TAA   2562-2564           TAG   2568-2570           TAA   2571-2573           TAG   2571-2573           TGA   2571-2573           TAA   2574-2576           TAG   2574-2576           TGA   2574-2576           TAA   2577-2579           TAG   2580-2582           TAA   2583-2585           TAA   2586-2588           TAA   2589-2591           TAG   2592-2594           TAA   2595-2597           TAG   2598-2600           TAG   2601-2603           TAA   2604-2606           TAG   2604-2606           TGA   2604-2606           TAA   2607-2609           TAA   2610-2612           TAG   2610-2612           TGA   2610-2612           TAA   2616-2618           TAG   2616-2618           TGA   2616-2618           TAG   2619-2621           TAG   2625-2627           TAG   2628-2630           TAA   2631-2633           TAA   2637-2639           TAG   2643-2645           TAA   2646-2648           TAA   2649-2651           TAA   2652-2654           TAG   2655-2657           TAA   2658-2660           TAG   2661-2663           TAG   2664-2666           TAA   2667-2669           TAG   2670-2672           TAG   2676-2678           TAG   2679-2681           TAA   2685-2687           TAG   2685-2687           TGA   2685-2687           TAA   2688-2690           TAG   2688-2690           TGA   2688-2690           TAA   2694-2696           TGA   2694-2696           TAA   2697-2699           TAA   2700-2702           TAG   2700-2702           TGA   2700-2702           TAA   2703-2705           TAG   2706-2708           TAA   2709-2711           TAG   2709-2711           TGA   2709-2711           TAA   2712-2714           TAA   2721-2723           TAG   2721-2723           TGA   2721-2723           TAA   2724-2726           TAG   2724-2726           TGA   2724-2726           TAG   2727-2729           TAA   2733-2735           TAG   2733-2735           TGA   2733-2735           TAA   2736-2738           TAG   2736-2738           TGA   2736-2738           TAA   2739-2741           TAG   2745-2747           TAA   2748-2750           TAG   2751-2753           TAG   2754-2756           TAG   2757-2759           TAG   2760-2762           TAA   2763-2765           TAG   2763-2765           TGA   2763-2765           TAG   2766-2768           TAA   2769-2771           TAA   2772-2774           TAG   2772-2774           TGA   2772-2774           TAA   2775-2777           TAG   2775-2777           TGA   2775-2777           TAG   2778-2780           TAA   2784-2786           TAG   2784-2786           TGA   2784-2786           TAG   2787-2789           TAA   2790-2792           TAG   2790-2792           TGA   2790-2792           TAA   2793-2795           TAG   2793-2795           TGA   2793-2795           TAA   2796-2798           TAA   2799-2801           TGA   2799-2801           TAA   2805-2807           TAA   2811-2813           TAG   2814-2816           TAA   2817-2819           TAA   2820-2822           TAG   2820-2822           TGA   2820-2822           TAG   2823-2825           TAA   2826-2828           TAG   2826-2828           TGA   2826-2828           TAG   2829-2831           TAA   2835-2837           TAG   2838-2840           TAG   2841-2843           TAA   2844-2846           TAG   2850-2852           TAA   2853-2855           TAA   2856-2858           TGA   2856-2858           TAG   2859-2861           TAA   2862-2864           TAG   2862-2864           TGA   2862-2864           TAA   2865-2867           TAA   2868-2870           TAA   2871-2873           TAG   2877-2879           TAA   2883-2885           TGA   2883-2885           TAG   2886-2888           TAA   2889-2891           TAA   2892-2894           TAA   2895-2897           TAG   2898-2900           TAG   2901-2903           TAA   2904-2906           TAG   2904-2906           TGA   2904-2906           TAG   2910-2912           TAG   2913-2915           TAG   2916-2918           TAA   2922-2924           TGA   2922-2924           TAG   2925-2927           TAA   2928-2930           TAG   2934-2936           TAG   2937-2939           TAA   2940-2942           TAG   2943-2945           TAA   2946-2948           TAA   2949-2951           TAG   2949-2951           TGA   2949-2951           TAA   2952-2954           TAA   2955-2957           TAA   2958-2960           TAG   2961-2963           TAG   2964-2966           TAA   2967-2969           TAG   2967-2969           TGA   2967-2969           TAA   2970-2972           TAA   2973-2975           TAG   2973-2975           TGA   2973-2975           TAA   2976-2978           TAG   2976-2978           TGA   2976-2978           TAA   2982-2984           TAG   2982-2984           TGA   2982-2984           TAA   2985-2987           TAG   2985-2987           TGA   2985-2987           TAA   2991-2993           TAG   2991-2993           TGA   2991-2993           TAA   2994-2996           TAG   2997-2999           TAA   3000-3002           TAG   3003-3005           TAA   3006-3008           TAG   3009-3011           TAA   3015-3017           TAA   3018-3020           TAA   3024-3026           TAA   3027-3029           TAG   3033-3035           TAA   3039-3041           TAG   3039-3041           TGA   3039-3041           TAA   3045-3047           TAA   3051-3053           TAG   3051-3053           TGA   3051-3053           TAA   3057-3059           TAA   3069-3071           TAG   3069-3071           TGA   3069-3071           TAA   3075-3077           TAA   3078-3080           TAA   3081-3083           TAG   3081-3083           TGA   3081-3083           TAA   3084-3086           TAG   3084-3086           TGA   3084-3086           TAG   3087-3089           TAA   3090-3092           TAA   3093-3095           TAA   3096-3098           TAA   3099-3101           TAG   3099-3101           TGA   3099-3101           TAA   3102-3104           TAA   3105-3107           TGA   3105-3107           TAA   3108-3110           TAG   3117-3119           TAG   3120-3122           TAA   3123-3125           TAA   3126-3128           TAG   3126-3128           TGA   3126-3128           TAG   3129-3131           TAG   3132-3134           TAA   3138-3140           TAG   3138-3140           TGA   3138-3140           TAA   3141-3143           TAA   3144-3146           TAG   3144-3146           TGA   3144-3146           TAG   3150-3152           TAA   3153-3155           TAG   3156-3158           TAA   3159-3161           TAG   3162-3164           TAA   3165-3167           TAG   3168-3170           TAA   3171-3173           TGA   3171-3173           TAA   3174-3176           TAA   3180-3182           TAA   3183-3185           TAG   3186-3188           TAA   3189-3191           TGA   3189-3191           TAA   3192-3194           TAA   3195-3197           TAA   3198-3200           TAA   3204-3206           TAA   3207-3209           TAA   3210-3212           TAA   3213-3215           TAG   3216-3218           TAA   3219-3221           TAG   3222-3224           TAA   3225-3227           TAG   3225-3227           TGA   3225-3227           TAA   3228-3230           TAG   3231-3233           TAG   3234-3236           TAA   3237-3239           TAA   3240-3242           TAG   3240-3242           TGA   3240-3242           TAA   3243-3245           TAA   3246-3248           TAA   3249-3251           TAA   3252-3254           TAG   3255-3257           TAG   3258-3260           TAG   3261-3263           TAA   3264-3266           TAG   3264-3266           TGA   3264-3266           TAA   3267-3269           TAA   3270-3272           TAA   3273-3275           TAG   3276-3278           TAG   3279-3281           TAG   3282-3284           TAA   3285-3287           TAG   3285-3287           TGA   3285-3287           TAA   3288-3290           TAA   3291-3293           TAA   3294-3296           TAG   3297-3299           TAA   3300-3302           TAG   3303-3305           TAA   3306-3308           TAG   3306-3308           TGA   3306-3308           TAA   3309-3311           TAG   3312-3314           TAG   3315-3317           TAA   3318-3320           TAA   3321-3323           TAG   3327-3329           TAG   3330-3332           TAG   3336-3338           TAA   3339-3341           TAA   3342-3344           TAA   3345-3347           TAG   3348-3350           TAA   3354-3356           TAA   3357-3359           TAG   3357-3359           TGA   3357-3359           TAA   3360-3362           TGA   3360-3362           TAG   3363-3365           TAA   3366-3368           TAA   3372-3374           TAA   3375-3377           TAG   3375-3377           TGA   3375-3377           TAG   3378-3380           TAG   3381-3383           TAA   3384-3386           TAG   3384-3386           TGA   3384-3386           TAG   3393-3395           TAG   3396-3398           TAA   3399-3401           TAG   3399-3401           TGA   3399-3401           TAA   3402-3404           TAA   3408-3410           TAG   3417-3419           TAA   3420-3422           TAA   3423-3425           TAA   3426-3428           TAG   3426-3428           TGA   3426-3428           TAA   3429-3431           TAG   3438-3440           TAA   3441-3443           TAA   3444-3446           TAA   3447-3449           TAG   3453-3455           TAA   3456-3458           TAG   3456-3458           TGA   3456-3458           TAG   3459-3461           TAG   3462-3464           TAG   3465-3467           TAG   3468-3470           TAA   3474-3476           TGA   3474-3476           TAG   3477-3479           TAA   3480-3482           TAA   3483-3485           TAG   3486-3488           TAA   3489-3491           TAG   3489-3491           TGA   3489-3491           TAA   3492-3494           TAG   3492-3494           TGA   3492-3494           TAA   3498-3500           TAG   3498-3500           TGA   3498-3500           TAA   3504-3506           TGA   3504-3506           TAA   3507-3509           TAG   3507-3509           TGA   3507-3509           TAG   3510-3512           TAA   3513-3515           TAA   3516-3518           TAG   3516-3518           TGA   3516-3518           TAG   3519-3521           TAA   3528-3530           TAG   3531-3533           TAA   3534-3536           TAA   3537-3539           TAG   3543-3545           TAA   3546-3548           TAG   3546-3548           TGA   3546-3548           TAG   3552-3554           TAA   3555-3557           TAG   3555-3557           TGA   3555-3557           TAA   3558-3560           TAG   3558-3560           TGA   3558-3560           TAG   3561-3563           TAA   3564-3566           TGA   3564-3566           TAG   3570-3572           TAG   3573-3575           TAA   3579-3581           TAG   3579-3581           TGA   3579-3581           TAG   3582-3584           TAG   3585-3587           TAG   3588-3590           TAG   3591-3593           TAA   3594-3596           TAA   3597-3599           TAG   3600-3602           TAG   3603-3605           TAA   3606-3608           TAA   3609-3611           TAA   3612-3614           TAG   3612-3614           TGA   3612-3614           TAG   3615-3617           TAG   3618-3620           TAA   3621-3623           TAG   3624-3626           TAA   3627-3629           TAA   3630-3632           TAG   3633-3635           TAA   3636-3638           TAA   3639-3641           TAG   3639-3641           TGA   3639-3641           TAG   3642-3644           TAG   3645-3647           TAA   3648-3650           TAG   3648-3650           TGA   3648-3650           TAA   3651-3653           TAA   3654-3656           TAA   3657-3659           TAG   3660-3662           TAA   3666-3668           TGA   3666-3668           TAG   3669-3671           TAG   3672-3674           TAA   3678-3680           TAA   3681-3683           TAA   3684-3686           TGA   3684-3686           TAA   3690-3692           TAA   3696-3698           TAG   3696-3698           TGA   3696-3698           TAA   3699-3701           TAA   3705-3707           TAA   3711-3713           TAG   3711-3713           TGA   3711-3713           TAG   3714-3716           TAG   3720-3722           TAA   3723-3725           TAG   3723-3725           TGA   3723-3725           TAA   3729-3731           TAG   3732-3734           TAG   3735-3737           TAA   3738-3740           TAA   3741-3743           TGA   3741-3743           TAA   3744-3746           TAG   3744-3746           TGA   3744-3746           TAG   3747-3749           TAA   3750-3752           TAG   3750-3752           TGA   3750-3752           TAA   3753-3755           TAG   3753-3755           TGA   3753-3755           TAG   3756-3758           TAG   3759-3761           TAA   3762-3764           TGA   3762-3764           TAA   3765-3767           TAG   3765-3767           TGA   3765-3767           TAA   3768-3770           TAG   3768-3770           TGA   3768-3770           TAA   3771-3773           TAG   3774-3776           TAG   3777-3779           TAG   3780-3782           TAG   3783-3785           TAA   3792-3794           TAG   3792-3794           TGA   3792-3794           TAA   3795-3797           TAG   3795-3797           TGA   3795-3797           TAA   3804-3806           TAG   3804-3806           TGA   3804-3806           TAA   3807-3809           TAG   3807-3809           TGA   3807-3809           TAA   3810-3812           TAG   3810-3812           TGA   3810-3812           TAG   3813-3815           TAA   3816-3818           TAG   3819-3821           TAA   3822-3824           TAA   3825-3827           TAA   3828-3830           TAA   3834-3836           TAG   3834-3836           TGA   3834-3836           TAA   3840-3842           TAG   3840-3842           TGA   3840-3842           TAA   3843-3845           TAA   3846-3848           TAA   3852-3854           TAA   3855-3857           TAG   3858-3860           TAG   3861-3863           TAA   3864-3866           TAG   3867-3869           TAA   3870-3872           TAG   3870-3872           TGA   3870-3872           TAA   3876-3878           TAG   3876-3878           TGA   3876-3878           TAA   3879-3881           TAA   3882-3884           TGA   3882-3884           TAA   3885-3887           TAG   3888-3890           TAG   3891-3893           TAA   3894-3896           TGA   3894-3896           TAA   3897-3899           TAG   3897-3899           TGA   3897-3899           TAA   3900-3902           TAG   3900-3902           TGA   3900-3902           TAA   3903-3905           TAG   3903-3905           TGA   3903-3905           TAA   3906-3908           TAG   3906-3908           TGA   3906-3908           TAA   3909-3911           TGA   3909-3911           TAA   3912-3914           TGA   3912-3914           TAA   3915-3917           TAA   3918-3920           TAG   3918-3920           TGA   3918-3920           TAA   3921-3923           TAG   3924-3926           TAA   3927-3929           TAG   3927-3929           TGA   3927-3929           TAA   3930-3932           TAA   3933-3935           TAG   3939-3941           TAA   3942-3944           TAA   3945-3947           TAG   3945-3947           TGA   3945-3947           TAG   3948-3950           TAA   3951-3953           TAG   3954-3956           TAA   3957-3959           TAG   3957-3959           TGA   3957-3959           TAG   3963-3965           TAA   3975-3977           TAG   3978-3980           TAG   3981-3983           TAA   3984-3986           TAA   3987-3989           TAA   3990-3992           TAG   3990-3992           TGA   3990-3992           TAA   3993-3995           TAG   3993-3995           TGA   3993-3995           TAG   3996-3998           TAA   3999-4001           TAA   4002-4004           TAG   4002-4004           TGA   4002-4004           TAA   4005-4007           TAG   4005-4007           TGA   4005-4007           TAA   4008-4010           TAG   4008-4010           TGA   4008-4010           TAA   4011-4013           TAG   4011-4013           TGA   4011-4013           TAA   4017-4019           TAG   4017-4019           TGA   4017-4019           TAA   4020-4022           TAG   4023-4025           TAA   4026-4028           TAG   4026-4028           TGA   4026-4028           TAG   4029-4031           TAG   4032-4034           TAA   4035-4037           TAG   4035-4037           TGA   4035-4037           TAA   4038-4040           TGA   4038-4040           TAG   4041-4043           TAA   4044-4046           TAA   4047-4049           TAA   4050-4052           TAA   4053-4055           TAG   4059-4061           TAA   4065-4067           TAG   4065-4067           TGA   4065-4067           TAA   4068-4070           TAG   4068-4070           TGA   4068-4070           TAA   4071-4073           TGA   4071-4073           TAG   4074-4076           TAA   4077-4079           TAG   4077-4079           TGA   4077-4079           TAA   4080-4082           TAG   4080-4082           TGA   4080-4082           TAA   4083-4085           TAA   4089-4091           TAA   4092-4094           TGA   4092-4094           TAA   4101-4103           TAG   4101-4103           TGA   4101-4103           TAG   4104-4106           TAA   4107-4109           TAG   4113-4115           TAG   4116-4118           TAG   4119-4121           TAA   4125-4127           TGA   4125-4127           TAG   4128-4130           TAA   4131-4133           TAG   4134-4136           TAA   4137-4139           TAG   4137-4139           TGA   4137-4139           TAG   4140-4142           TAA   4143-4145           TAG   4143-4145           TGA   4143-4145           TAG   4146-4148           TAG   4149-4151           TAG   4152-4154           TAG   4155-4157           TAA   4158-4160           TAG   4161-4163           TAA   4164-4166           TAG   4167-4169           TAA   4170-4172           TAG   4170-4172           TGA   4170-4172           TAG   4173-4175           TAG   4176-4178           TAA   4179-4181           TAA   4182-4184           TAG   4188-4190           TAG   4191-4193           TAA   4197-4199           TAA   4200-4202           TAG   4203-4205           TAA   4206-4208           TAG   4206-4208           TGA   4206-4208           TAA   4209-4211           TAA   4212-4214           TAG   4212-4214           TGA   4212-4214           TAG   4215-4217           TAG   4218-4220           TAG   4221-4223           TAG   4224-4226           TAA   4227-4229           TAG   4227-4229           TGA   4227-4229           TAG   4230-4232           TAA   4233-4235           TAG   4233-4235           TGA   4233-4235           TAG   4236-4238           TAA   4239-4241           TGA   4239-4241           TAG   4242-4244           TAA   4245-4247           TAA   4248-4250           TAG   4251-4253           TAA   4254-4256           TAG   4254-4256           TGA   4254-4256           TAG   4257-4259           TAG   4260-4262           TAA   4263-4265           TAG   4263-4265           TGA   4263-4265           TAA   4266-4268           TAG   4266-4268           TGA   4266-4268           TAG   4269-4271           TAA   4275-4277           TAG   4275-4277           TGA   4275-4277           TAA   4278-4280           TAG   4278-4280           TGA   4278-4280           TAA   4284-4286           TGA   4284-4286           TAG   4287-4289           TAA   4290-4292           TAA   4293-4295           TAG   4293-4295           TGA   4293-4295           TAA   4296-4298           TAA   4299-4301           TAA   4308-4310           TGA   4308-4310           TAG   4311-4313           TAA   4314-4316           TAA   4317-4319           TAA   4326-4328           TAA   4332-4334           TGA   4332-4334           TAA   4335-4337           TAG   4347-4349           TAA   4350-4352           TAG   4353-4355           TAG   4356-4358           TAG   4362-4364           TAG   4365-4367           TAG   4368-4370           TAA   4371-4373           TAG   4371-4373           TGA   4371-4373           TAG   4374-4376           TAG   4383-4385           TAA   4386-4388           TGA   4386-4388           TAA   4395-4397           TAG   4395-4397           TGA   4395-4397           TAA   4398-4400           TAA   4401-4403           TAA   4404-4406           TAG   4404-4406           TGA   4404-4406           TAA   4410-4412           TAG   4410-4412           TGA   4410-4412           TAA   4413-4415           TAA   4416-4418           TAA   4419-4421           TAG   4422-4424           TAA   4425-4427           TAG   4425-4427           TGA   4425-4427           TAA   4428-4430           TAG   4428-4430           TGA   4428-4430           TAG   4431-4433           TAG   4437-4439           TAG   4440-4442           TAA   4449-4451           TAG   4455-4457           TAA   4461-4463           TAA   4464-4466           TAA   4467-4469           TAG   4467-4469           TGA   4467-4469           TAG   4470-4472           TAA   4473-4475           TAG   4476-4478           TAG   4479-4481           TAA   4482-4484           TAG   4482-4484           TGA   4482-4484           TAA   4485-4487           TAA   4488-4490           TAG   4488-4490           TGA   4488-4490           TAA   4494-4496           TGA   4494-4496           TAA   4497-4499           TAA   4500-4502           TAG   4503-4505           TAA   4506-4508           TAG   4506-4508           TGA   4506-4508           TAA   4512-4514           TAA   4515-4517           TAA   4521-4523           TGA   4521-4523           TAG   4527-4529           TAG   4530-4532           TAA   4536-4538           TAG   4536-4538           TGA   4536-4538           TAG   4539-4541           TAG   4542-4544           TAA   4545-4547           TAA   4548-4550           TAG   4548-4550           TGA   4548-4550           TAG   4551-4553           TAG   4554-4556           TAA   4557-4559           TAG   4557-4559           TGA   4557-4559           TAG   4560-4562           TAG   4563-4565           TAA   4566-4568           TAA   4569-4571           TAG   4569-4571           TGA   4569-4571           TAA   4572-4574           TAA   4575-4577           TAA   4578-4580           TAA   4581-4583           TAA   4584-4586           TAG   4587-4589           TAG   4593-4595           TAG   4596-4598           TAG   4599-4601           TAA   4602-4604           TAA   4605-4607           TAG   4605-4607           TGA   4605-4607           TAA   4608-4610           TAG   4608-4610           TGA   4608-4610           TAA   4614-4616           TAG   4614-4616           TGA   4614-4616           TAA   4617-4619           TAA   4620-4622           TAG   4620-4622           TGA   4620-4622           TAA   4626-4628           TAG   4626-4628           TGA   4626-4628           TAA   4629-4631           TAG   4629-4631           TGA   4629-4631           TAG   4632-4634           TAG   4635-4637           TAA   4638-4640           TAA   4641-4643           TAG   4641-4643           TGA   4641-4643           TAA   4644-4646           TAG   4644-4646           TGA   4644-4646           TAA   4647-4649           TAA   4653-4655           TAA   4656-4658           TAG   4656-4658           TGA   4656-4658           TAA   4659-4661           TAG   4659-4661           TGA   4659-4661           TAG   4662-4664           TAA   4665-4667           TGA   4665-4667           TAA   4674-4676           TGA   4674-4676           TAA   4677-4679           TAA   4680-4682           TAA   4683-4685           TAG   4683-4685           TGA   4683-4685           TAA   4689-4691           TAG   4689-4691           TGA   4689-4691           TAG   4695-4697           TAG   4698-4700           TAA   4704-4706           TAA   4707-4709           TAG   4710-4712           TAG   4713-4715           TAG   4716-4718           TAG   4719-4721           TAG   4722-4724           TAG   4725-4727           TAG   4737-4739           TAG   4740-4742           TAA   4743-4745           TAG   4743-4745           TGA   4743-4745           TAG   4746-4748           TAG   4755-4757           TAA   4758-4760           TAG   4758-4760           TGA   4758-4760           TAA   4761-4763           TGA   4761-4763           TAG   4764-4766           TAA   4767-4769           TAA   4770-4772           TAG   4770-4772           TGA   4770-4772           TAA   4773-4775           TAG   4773-4775           TGA   4773-4775           TAA   4776-4778           TAG   4776-4778           TGA   4776-4778           TAA   4782-4784           TAG   4788-4790           TAG   4794-4796           TAG   4797-4799           TAA   4800-4802           TAA   4806-4808           TAG   4806-4808           TGA   4806-4808           TAG   4812-4814           TAA   4815-4817           TAG   4815-4817           TGA   4815-4817           TAG   4818-4820           TAA   4821-4823           TAA   4824-4826           TAA   4830-4832           TAG   4830-4832           TGA   4830-4832           TAA   4833-4835           TAG   4833-4835           TGA   4833-4835           TAG   4836-4838           TAG   4839-4841           TAG   4845-4847           TAA   4848-4850           TAG   4848-4850           TGA   4848-4850           TAG   4851-4853           TAA   4857-4859           TAG   4857-4859           TGA   4857-4859           TAG   4860-4862           TAG   4863-4865           TAA   4866-4868           TAG   4869-4871           TAG   4875-4877           TAA   4878-4880           TAG   4878-4880           TGA   4878-4880           TAG   4881-4883           TAG   4887-4889           TAG   4890-4892           TAA   4893-4895           TAA   4896-4898           TAA   4902-4904           TAG   4902-4904           TGA   4902-4904           TAA   4905-4907           TAG   4905-4907           TGA   4905-4907           TAA   4908-4910           TAA   4911-4913           TAG   4911-4913           TGA   4911-4913           TAG   4914-4916           TAA   4917-4919           TAG   4917-4919           TGA   4917-4919           TAA   4920-4922           TGA   4920-4922           TAG   4923-4925           TAA   4932-4934           TAG   4932-4934           TGA   4932-4934           TAA   4935-4937           TGA   4935-4937           TAG   4938-4940           TAG   4941-4943           TAG   4944-4946           TAA   4947-4949           TAG   4947-4949           TGA   4947-4949           TAG   4950-4952           TAG   4956-4958           TAG   4962-4964           TAG   4965-4967           TAG   4968-4970           TAA   4974-4976           TAA   4977-4979           TAG   4980-4982           TAA   4983-4985           TAG   4986-4988           TAG   4989-4991           TAA   4992-4994           TAG   4992-4994           TGA   4992-4994           TAA   4995-4997           TAG   4998-5000           TAA   5001-5003           TAG   5004-5006           TAG   5007-5009           TAA   5010-5012           TAG   5013-5015           TAA   5016-5018           TGA   5016-5018           TAA   5019-5021           TAG   5022-5024           TAA   5025-5027           TGA   5025-5027           TAG   5031-5033           TAA   5034-5036           TAG   5034-5036           TGA   5034-5036           TAA   5037-5039           TGA   5037-5039           TAG   5040-5042           TAA   5043-5045           TAG   5043-5045           TGA   5043-5045           TAA   5046-5048           TAG   5049-5051           TAA   5052-5054           TAG   5055-5057           TAA   5058-5060           TAA   5061-5063           TAA   5064-5066           TAA   5067-5069           TAA   5070-5072           TAG   5070-5072           TGA   5070-5072           TAA   5073-5075           TAG   5076-5078           TGA   5091-5093                      
 
       [0047] Insertion mutant BRCA1 genes containing a truncating mutation may also be defined as having the sequence 5′ R1-R2-R3 3′; where R1 is the wild type BRCA1 DNA sequence from nucleotide number 120 to X; R2 is 3n+1 or 3n+2 nucleotides of any sequence where n is an integer of zero or greater; R3 contains the wild type BRCA1 DNA sequence of nucleotide number X+1 to 5711, and where X=123 to 5707.  
       [0048] Alternatively, an insertion mutant BRCA1 gene or fragment thereof containing a truncating mutation is capable of specifically hybridizing to an oligonucleotide probe being at least 9 nucleotides in length and having the sequence 5′ R1-R2-R3 3′; where R1 contains at its 3′ end three nucleotides complementary to nucleotide numbers X-2, X-1 and X of the wild-type BRCA1 gene; R2=an oligonucleotide having Y nucleotides of any sequence; R3 contains at its 5′ end three nucleotides complementary to nucleotide numbers X+1, X+2 and X+3 of the wild type BRCA1 gene; where Y is 3n+1 or 3n+2 where n is an integer of zero to 1861, and where X=122 to 5707.  
       [0049] It should be recognized that for TABLES 4-7, each line indicating a stop codon represents several different mutations, each one of which creates the same truncating stop codon. For example, in TABLE 4, the line indicated by TGA stop codon at 207-209 represents twenty-four different mutations, 185delA, 186delG, 187delA, 188delG, 189delT, 190delG, 191 delT, 192delC, 193delC, 194delC, 195delA, 196delT, 197delC, 198delT, 199delG, 200delT, 201delC, 202delT, 203delG, 204delG, 205delA, 206delG, 207delT, 208delT. The corresponding mutations for each line in each table are easily determined by anyone of very modest skill in the art knowing only the BRCA1 sequence such as given SEQ ID NO:1 and TABLES 4-7.  
       [0050] A substantially complete listing of all of the mutations, their sites etc. of the present invention is described in Appendix A, B, C, D and E. Likewise, the choice of mutations and corresponding oligonucleotides may be chosen from and determined by the list in Appendix A-E.  
       [0051] An alternative method for defining the mutations of the present invention is by their nucleotide numbers. Mutant BRCA1 genes having nonsense mutations may be described as having the nucleotide sequence R4-R5-R6, where R4 is nucleotide numbers 120 to 3×of the BRCA1 gene; R5 is TAG, TAA or TGA; and R6 is nucleotide numbers 3X+4 to 5711 of the BRCA1 gene; where X is 41 to 1903.  
       [0052] Mutant BRCA1 genes having deletion mutations may be described as having the nucleotide sequence R4-R5, where R4 is nucleotide numbers 120 to Y of the BRCA1 gene; and R5 is nucleotide numbers Y+Z+1 to 5711 of the BRCA1 gene; where Y is 124 to 5707, and Z is 3n+1 or 3n+2 where N is an integer of zero or greater.  
       [0053] Mutant BRCA1 genes having insertion mutations may be described as having the nucleotide sequence R4-R5-R6, where R4 is nucleotide numbers 120 to Y of the BRCA1 gene; R5 is 3n+1 or 3n+2 nucleotides of any sequence where n is an integer of zero or greater; and R6 is nucleotides Y+1 to 5711; wherein Y is from 122 to 5707.  
       [0054] While the present invention encompasses genes with numerous mutations in the BRCA1 gene, applicant reserves the right to lessen the scope and number of mutations to be included in the present invention.  
       [0055] It should be recognized that mutations causing truncations which form a smaller protein molecule than mutations causing truncations of known mutations associated with cancer are expected to also be associated with cancer. Removing additional amino acids from a non-function protein is also believed to result in a non-functional protein.  
       [0056] Useful oligonucleotides according to the present invention are those which will specifically hybridize to BRCA1 sequences in the region of the mutations. The oligonucleotides of the present invention are preferably “biologically active” with respect to structural attributes, such as the capacity of a nucleic acid to hybridize to another nucleic acid molecule or to be used by a polymerase as a primer. Alternatively, such attributes may be catalytic, and thus involve the capacity of the agent to mediate a chemical reaction or response. Typically these oligonucleotides are about 13 to 27 nucleotides in length (longer for large insertions) and have the nucleotide sequence corresponding to the region of the mutations at their respective nucleotide locations on the BRCA1 sequence. Such molecules can be labeled, according to any technique known in the art, such as with radiolabels, fluorescent labels, enzymatic labels, sequence tags, biotin, other ligands, etc.  
       [0057] According to another aspect of the invention, the oligonucleotides contain one or more of the specific mutations constituting DNA probes. Generally it is preferred for each DNA probe to encompass only one mutation. Such molecules may be labeled and can be used as allele-specific oligonucleotide probes to detect the mutation of interest.  
       [0058] Alternatively, the oligonucleotide may be one primer of a PCR primer pair, which upon annealing, will amplify a product. In the situation wherein the target DNA sample does not contain a sequence complementary to the oligonucleotide, annealing does not occur, and thus amplification of a product does not occur.  
       [0059] Polynucleotide-containing biological samples, such as blood, can be tested to determine whether the BRCA1 gene contains one of the specific mutations listed above. To amplify the BRCA1 gene, one may use PCR using primers which hybridize to the ends of the exons or to the introns flanking the exons. To detect mutations in the introns, primers amplifying the introns, especially the regions adjacent to the exons (particularly the splice site regions), may be used. Examples of suitable primers are given in Friedman et al.,  Nat. Genetics,  8:399-404 (1994).  
       [0060] Amplification may also be performed by a number of other techniques, such as by cloning the gene or gene fragments, and linking the BRCA1 gene or fragments thereof in the sample to a vector. “Shot gun” cloning is particularly preferred. For the purposes of this to application, a vector may be any polynucleotide containing system which induces replication such as a plasmid, cosmid, virus, transposon, or portions thereof.  
       [0061] In one embodiment of the invention, the BRCA1 gene or A DNA fragment complementary to its coding sequence is ligated to a vector which is placed inside a suitable host cell or other system for replicating the vector. After replication, the BRCA1 gene or its fragments are then separated from the vector, e.g. by restriction endonuclease digestion, to amplify the copy number of BRCA1 in a particular preparation.  
       [0062] Probes are synthesized to specifically hybridize to any of the list of mutations in TABLES 3-7. On each side of the mutation, the probe overlaps at least 3 nucleotides so that the probes specifically hybridize to a DNA with the mutation. Likewise for probes specific to the mutation site with a sequence complementary for the wild type DNA sequence. By using either or both (if the sample is heterozygous) of these probes which differentially hybridize to mutant and wild-type BRCA1 sequences, one can determine the presence or absence of a mutant BRCA1 gene. Probes which hybridize to the complementary strand of the target DNA may also be used in the same manner.  
       [0063] A pair of isolated allele specific oligonucleotide probes are provided for the mutation 185delAG.  
                                  wild-type   5′-AAT CTT AGA GTG TCC CA-3′,   SEQ ID NO:3                   mutant   5′-ATC TTA GTG TCC CAC CT-3′,   SEQ ID NO:4          
 
       [0064] SEQ ID NO:3 preferentially may be hybridized to a target BRCA1 sequence under conditions where this probe anneals with a wild type BRCA1 gene or gene fragments, whereas SEQ ID NO:4 preferentially may be hybridized to a target BRCA1 sequence under conditions where this probe anneals with BRCA1 gene or gene fragments containing the 185delAG mutation.  
       [0065] A pair of isolated allele specific oligonucleotide probes are provided for the mutation 1136insA.  
                                  wild-type   5′-CAG AAA AAA AGG TAG AT-3′,   SEQ ID NO:5                   mutant   5′-CAG AAA AAA AAG GTA GA-3′,   SEQ ID NO:6          
 
       [0066] SEQ ID NO:5 preferentially may be hybridized to a target BRCA1 sequence under conditions where this probe anneals with a wild type BRCA1 gene or gene fragments, whereas SEQ ID NO:6 preferentially may be hybridized to a target BRCA1 sequence under conditions where this probe anneals with BRCA1 gene or gene fragments containing the 1136insA mutation.  
       [0067] A pair of isolated allele specific oligonucleotide probes are provided for the mutation 5382insC.  
                                  wild-type   5′-AGA GAA TCC CAG GAC AG-3′,   SEQ ID NO:7                   mutant   5′-AGA GAA TCC CCA GGA CA-3′,   SEQ ID NO:8          
 
       [0068] SEQ ID NO:9 preferentially may be hybridized to a target BRCA1 sequence under conditions where this probe anneals with a wild type BRCA1 gene or gene fragments, whereas SEQ ID NO:10 preferentially may be hybridized to a target BRCA1 sequence under conditions where this probe anneals with BRCA1 gene or gene fragments containing the 5382insC mutation.  
       [0069] A pair of isolated allele specific oligonucleotide probes are provided for the mutation C4446T.  
                                          wild-type                   5′-AGG ACC TGC GAA ATC CA-3′,   SEQ ID NO:9                       mutant           5′-AGG ACC TGT GAA ATC CA-3′,   SEQ ID NO:10          
 
       [0070] SEQ ID NO:11 preferentially may be hybridized to a target BRCA1 sequence under conditions where this probe anneals with a wild type BRCA1 gene or gene fragments, whereas SEQ ID NO:12 preferentially may be hybridized to a target BRCA1 sequence under conditions where this probe anneals with BRCA1 gene or gene fragments containing the C4446T mutation. Comparable probes can be prepared for each mutation of the present invention.  
       [0071] These allele specific oligonucleotides are useful in diagnosis of a subject at risk of having cancer. The allele specific oligonucleotides hybridize with a target polynucleotide sequence containing the mutations listed in TABLES 3-7. The probes having a sequence to naturally occurring (wild-type) BRCA1 hybridize preferentially to the wild type sequence and are useful, for example, as controls. The probes complementary to the sequences containing the mutations listed in TABLES 3-7 are designed to hybridize preferentially to the sequences carrying the specified mutant sequence.  
       [0072] The primers of the invention embrace oligonucleotides of sufficient length and appropriate sequence so as to provide initiation of polymerization on a significant number of nucleic acids in the mutated locus. Examples of preferred sequences for the primers of the present invention are given in the references cited above.  
       [0073] Environmental conditions conducive to synthesis of extension products include the presence of nucleoside triphosphates, an agent for polymerization, such as DNA polymerase, and suitable conditions such as temperature, ion composition, ionic strength and pH. The primer is preferably single stranded for maximum efficiency in amplification, but may be double stranded. If double stranded, the primer is preferably first treated to separate its strands before being used to prepare extension products. The primer must be sufficiently long to specifically prime the synthesis of extension products in the presence of the inducing agent for polymerization. The exact length of primer will depend on many factors, including temperature, buffer, and nucleotide composition. The oligonucleotide primer typically contains 13-20 or more nucleotides, although it may contain fewer nucleotides.  
       [0074] Primers of the invention are designed to be “substantially” complementary to each strand of the genomic locus to be amplified. This means that the primers must be sufficiently complementary to hybridize with their respective strands under conditions which allow the agent for polymerization to perform a polymerase-mediated primer extension reaction. In other words, the primers should have sufficient complementarity with the 5′ and 3′ sequences flanking the mutation to hybridize therewith and permit amplification of the genomic locus. “Substantially” the same as it refers to oligonucleotide sequences which have the functional ability to hybridize or anneal with sufficiently stringent conditions to generate sufficient specificity to distinguish between the presence or absence of the mutation. This is measurable by the temperature of melting being sufficiently different to permit easy identification of whether the oligonucleotide is binding to the normal or mutant BRCA1 gene sequence. Conventional stringency conditions are described, for example, by Sambrook et al, Molecular Cloning, a laboratory Manual, 2nd Edition, Cold Spring Harbor Press, Cold Spring Harbor, N.Y. (1989), more recent editions and Haymes, et al., Nucleic Acid Hybridization, A Practical Approach, IRL Press, Washington, D.C. (1985).  
       [0075] Oligonucleotide primers of the invention are employed in the amplification process, which is an enzymatic chain reaction that preferably produces exponential quantities of mutated locus relative to the number of reaction steps involved. Typically, one primer is complementary to the negative (−) strand of the mutated locus and the other is complementary to the positive (+) strand. Annealing the primers to denatured nucleic acid is generally followed by extension with an enzyme, such as the large fragment of DNA polymerase I (Klenow) and nucleotides, and results in newly synthesized + and − strands containing the target mutated locus sequence. Because these newly synthesized sequences are also templates, repeated cycles of denaturing, primer annealing, and extension results in exponential production of the region (i.e., the target mutated locus sequence) defined by the primers. The product of the chain reaction is a discreet nucleic acid duplex with termini corresponding to the ends of the specific primers employed.  
       [0076] The oligonucleotide primers of the invention may be prepared using any suitable method, such as conventional phosphotriester and phosphodiester methods or automated embodiments thereof. In one such automated embodiment, diethylphosphoramidites are used as starting materials and may be synthesized as described by Beaucage, et al.,  Tetrahedron Letters,  22:1859-1862, (1981). One method for synthesizing oligonucleotides on a modified solid support is described in U.S. Pat. No. 4,458,066.  
       [0077] Any nucleic acid specimen, in purified or non-purified form, can be utilized as the is starting nucleic acid or acids, providing it contains, or is suspected of containing, the specific nucleic acid sequence containing the mutated locus. Thus, the process may amplify, for example, DNA or RNA, including messenger RNA, wherein DNA or RNA may be single stranded or double stranded. In the event that RNA is to be used as a template, enzymes, and/or conditions optimal for reverse transcribing the template to DNA would preferably be utilized. In addition, a DNA-RNA hybrid which contains one strand of each may be utilized. A mixture of nucleic acids may also be employed, or the nucleic acids produced in a previous amplification reaction herein, using the same or different primers may be so utilized. The specific nucleic acid sequence to be amplified, i.e., the mutated locus, may be a fraction of a larger molecule or can. be present initially as a discrete molecule, so that the specific sequence constitutes the entire nucleic acid. It is not necessary that the sequence to be amplified be present initially in a pure form; it may be a minor fraction of a complex mixture, such as contained in whole human DNA.  
       [0078] DNA utilized herein may be extracted from a body sample, such as blood, tissue material and the like by a variety of techniques such as that described by Maniatis, et. al. in  Molecular Cloning: A Laboratory Manual,  Cold Spring Harbor, N.Y., p. 280-281, 1982). If the extracted sample is impure, it may be treated before amplification with an amount of a reagent effective to open the cells, or animal cell membranes of the sample, and to expose and/or separate the strand(s) of the nucleic acid(s). This lysing and nucleic acid denaturing step to expose and separate the strands will allow amplification to occur much more readily.  
       [0079] The deoxyribonucleotide triphosphates dATP, dCTP, dGTP, and dTTP are added to the synthesis mixture, either separately or together with the primers, in adequate amounts and the resulting solution is heated to about 90′-100° C. from about 1 to 10 minutes, preferably from 1 to 4 minutes. This is sufficient to denature any double strands. After this heating period, the solution is allowed to cool at a rate which is preferable for the primer hybridization. To the cooled mixture is added an appropriate agent for effecting the primer extension reaction (called herein agent for polymerization), and the reaction is allowed to occur under conditions known in the art. The agent for polymerization may also be added together with the other reagents if it is heat stable. This synthesis (or amplification) reaction may occur at room temperature up to a temperature above which the agent for polymerization no longer functions. Thus, for example, if DNA polymerase is used as the agent, the temperature is generally no greater than about 40° C. Thermostable DNA polymerases, such as Taq polymerase, may function at a higher temperature.  
       [0080] The agent for polymerization may bge any compound or system which will function to accomplish the synthesis of primer extension products, including enzymes. Suitable enzymes for this purpose include, for example,  E. coli  DNA polymerase I, Klenow fragment of  E. coli  DNA polymerase, polymerase muteins, reverse transcriptase, other enzymes, including heat-stable enzymes (i e., those enzymes which perform primer extension after being subjected to temperatures sufficiently elevated to cause denaturation), such as Taq polymerase. The suitable enzyme will facilitate combination of the nucleotides in the proper manner to form the primer extension products which are complementary to each nucleic acid strand. Generally, the synthesis will be initiated at the 3′ end of each primer and proceed in the 5′ direction along the template strand, until synthesis terminates, producing molecules of different lengths.  
       [0081] The newly synthesized strand and its complementary nucleic acid strand will form a double-stranded molecule under hybridizing conditions described above and this hybrid is used in subsequent steps of the process. In the next step, the newly synthesized double-stranded molecule is subjected to denaturing conditions using any of the procedures described above to provide single-stranded molecules.  
       [0082] The steps of denaturing, annealing, and extension product synthesis can be repeated as often as needed to amplify the target nucleic acid sequence to the extent necessary for detection. The amount of the specific nucleic acid sequence produced will accumulate in an exponential fashion (PCR. A Practical Approach, ILR Press, Eds. M. J. McPherson, P. Quirke, and G. R; Taylor, 1992).  
       [0083] The amplification products may be detected by Southern blot analysis using non-isotopic detection methods. In such a process, for example, a small sample of DNA containing a very low level of the nucleic acid sequence of the polymorphic locus is amplified, and analyzed via a Southern blotting technique or similarly, using dot blot analysis. The use of non-radioactive probes or labels is facilitated by the high level of the amplified signal. Alternatively, probes used to detect the amplified products can be directly or indirectly detectably labeled, for example, with a radioisotope, a fluorescent compound, a bioluminescent compound, a chemiluminescent compound, a metal chelator or an enzyme. Those of ordinary skill in the art will know of other suitable labels for binding to the probe, or will be able to ascertain such, using routine experimentation. In the preferred embodiment, the amplification products are determinable by separating the mixture on an agarose gel containing ethidium bromide which causes DNA to be fluorescent.  
       [0084] Sequences amplified by the methods of the invention can be further evaluated, detected, cloned, sequenced, and the like, either in solution or after binding to a solid support, by any method usually applied to the detection of a specific DNA sequence such as PCR, oligomer restriction (Saiki, et.al.,  Bio/Technology,  3:1008-1012, (1985)), allele-specific oligonucleotide (ASO) probe analysis (Conner, et. al.,  Proc. Natl. Acad. Sci. U.S.A.,  80:278, (1983)), oligonucleotide ligation assays (OLAs) (Landgren, et. al.,  Science,  241:1007, (1988)), and the like. Molecular techniques for DNA analysis have been reviewed (Landgren, et. al.,  Science,  242:229-237, (1988)).  
       [0085] Preferably, the method of amplifying is by PCR, as described herein and as is commonly used by those of ordinary skill in the art. Alternative methods of amplification have been described and can also be employed as long as the BRCA1 locus amplified by PCR using primers of the invention is similarly amplified by the alternative means. Such alternative amplification systems include but are not limited to self-sustained sequence replication, which begins with a short sequence of RNA of interest and a T7 promoter. Reverse transcriptase copies the RNA into cDNA and degrades the RNA, followed by reverse transcriptase polymerizing a second strand of DNA. Another nucleic acid amplification technique is nucleic acid sequence-based amplification (NASBA) which uses reverse transcription and T7 RNA polymerase and incorporates two primers to target its cycling scheme. NASBA can begin with either DNA or RNA and finish with either, and amplifies to 10 8  copies within 60 to 90 minutes. Alternatively, nucleic acid can be amplified by ligation activated transcription (LAT). LAT works from a single-stranded template with a single primer that is partially single-stranded and partially double-stranded. Amplification is initiated by ligating a cDNA to the promoter oligonucleotide and within a few hours, amplification is 10 8  to 10 9  fold. The QB replicase system can be utilized by attaching an RNA sequence called MDV-1 to RNA complementary to a DNA sequence of interest. Upon mixing with a sample, the hybrid RNA finds its complement among the specimen&#39;s mRNAs and binds, activating the replicase to copy the tag-along sequence of interest. Another nucleic acid amplification technique, ligase chain reaction (LCR), works by using two differently labeled halves of a sequence of interest which are covalently bonded by ligase in the presence of the contiguous sequence in a sample, forming a new target. The repair chain reaction (RCR) nucleic acid amplification technique uses two complementary and target-specific oligonucleotide probe pairs, thermostable polymerase and ligase, and DNA. nucleotides to geometrically amplify targeted sequences. A 2-base gap separates the oligonucleotide probe pairs, and the RCR fills and joins the gap, mimicking normal DNA repair. Nucleic acid amplification by strand displacement activation (SDA) typically utilizes a short primer containing a recognition site for Hinc II with short overhang on the 5′ end which binds to target DNA. A DNA polymerase fills in the part of the primer opposite the overhang with sulfur-containing adenine analogs. Hinc II is added but only cuts the unmodified DNA strand. A DNA polymerase that lacks 5′ exonuclease activity enters at the cite of the nick and begins to polymerize, displacing the initial primer strand downstream and building a new one which serves as more primer. SDA produces greater than 10 7 -fold amplification in 2 hours at 37° C. Unlike PCR and LCR, SDA does not require instrumented Temperature cycling. Another modification of the PCR is the TAQMAN amplification (PERKIN ELMER) where an oligonucleotide is labeled with a fluorescent and a quencher. This oligonucleotide anneals to the target between the primers so that when one primer is extended, the 5′ nuclease activity of Taq cleaves of the fluorescent label which is then qualitatively detected and quantitatively determined to correspond to the copy number of amplification. Although PCR is the preferred method of amplification in the invention, other methods such as the above can also be used to amplify the BRCA1 locus in accordance with the present invention.  
       [0086] To sequence the coding region of the BRCA1 gene, each exon is amplified separately using a pair of PCR primers and the resulting PCR products are sequenced in the forward and reverse directions. Any combination of the primers mentioned above which encompass the entire BRCA1 coding region may be used.  
       [0087] An alternative method for determining whether a truncating mutation is present is the Protein Truncation Assay (PTA). Protein truncation assay enables us to identify three types mutations in a truncated BRCA1 protein: nonsense mutation, frame shift mutation, and splice-site mutations. Nonsense mutations (see TABLE 3) result when a single base change in a codon creates a signal to terminate the production of the protein. These signals or stop codons come in three types: TGA, TAA, TAG. Frame shift mutations (see TABLES 4-7) occur when bases are added or deleted from the normal sequence. Thus, disrupting the reading frame of the protein and causing a stop codon downstream from the alteration. Splice-site mutations occurring at the intron/exon boundaries have the potential of causing the deletion of an entire exon. Examples of protein truncation assays for BRCA1 is mentioned in Furnari et al,  Proceedings of the National Academy of Sciences U.S.A.,  96: p. 12479-12484 (11-1997) and Tashiro et al,  Cancer Research,  57: 3935-3940 (1997).  
       [0088] Preferably, the Polymerase Chain Reaction (PCR) is performed to amplify the BRCA1 gene copy number. The amplified BRCA1 gene is transcribed and translated in vitro. Detection of truncated proteins is made possible by the use of polyacrylamide gel electrophoresis. The migration of the mutant band on the gel allows for size targeting of the alteration; thus reducing confirmatory sequencing to a minimum.  
       [0089] In another embodiment of the invention, a method is provided for diagnosing a subject having a predisposition or higher susceptibility to cancer, or other pathology associated with BRCA1 mutations, comprising sequencing a target nucleic acid of a sample from a subject by dideoxy sequencing following amplification of the target nucleic acid. In such an embodiment, one does not even need to use any of the oligonucleotides, either primers or probes as described herein. The BRCA1 gene, or fragments thereof, may be directly cloned and then sequenced. (such as by dideoxy methods) to determine the presence of absence of a mutation. In such a situation, one need only compare the sequence obtained to a naturally occurring (wild type) BRCA1 gene, or a portion thereof.  
       [0090] In another embodiment of the invention a method is provided for diagnosing a subject having a predisposition or higher susceptibility to cancer comprising contacting a target nucleic acid of a sample from a subject with a reagent that detects the presence of one of the mutations of the present invention and detecting the mutation.  
       [0091] In yet another embodiment of the invention, a method is provided for determining whether either gene therapy or protein therapy (with normal BRCA1 protein) is appropriate for the prevention or treatment of cancers and other BRCA1 related syndromes. For this method, BRCA1 mutations are assayed for in a biological sample for BRCA1 mutations. When present, the use of gene therapy or protein therapy to prevent cancer in the individual is appropriate. Likewise when BRCA1 mutations are found in tumor cells from a patient, gene therapy or protein therapy is appropriate for that individual.  
       [0092] In another embodiment of the invention, a method and reagents are provided for repairing the gene mutation in at least some cells by applying an oligomer comprising the sequence of the wild-type probes to repair the individual&#39;s genome by triple strand hybridization. See U.S. Pat. Nos. 5,650,316 and 5,624,803 for example. This is a form of gene therapy to correct the defect in either apparently normal tissue or in an active tumor. Gene repair may also be performed on excised tumor cells which may be helpful in determining the preferred therapy to be used, particularly the reagents used for gene therapy. Other forms of gene therapy, such as providing a complete copy of a normal BRCA1 gene may also be used. Some gene therapy techniques specific to BRCA1 are discussed in Furnari et al,  Proceedings of the National Academy of Sciences. U.S.A.,  96: p. 12479-12484 (11-1997).  
       [0093] Since the method of the present invention may be applied to detect a mutant BRCA1 gene in a fetus, therapeutic or preventative measures may be possible. Screening of eggs or sperm from heterozygous individuals may permit one to selectively conceive a zygote without the mutant BRCA1 gene since only one half of the sperm or eggs will contain the mutation.  
       [0094] In another embodiment of the invention a method is provided for characterizing a tumor. Histologic type, morphologic grade, differences between inherited and sporadic cancer appear to be distinguished. One method comprises sequencing the target nucleic acid isolated from the tumor or other biological sample to determine if the mutation is present. Sanger, et al.,  J. Mol. Biol.  142:1617 (1980).  
       [0095] Characterizing a tumor as having originated from an inherited gene, a known or suspected cause, or a sporadic cancer gene may be clinically significant as the prevalence of bilateral breast cancer is higher in individuals with a known mutation in a tumor suppressor gene than in sporadic cases. Weber, Scientific American, January-February p. 12-21 (1996). The tumor may be classified based on tissue taken from the tumor itself or from a non-tumor site which contains DNA.  
       [0096] Yet another embodiment of the present invention is an isolated mutant BRCA1 DNA sequence which may be the entire sequence, an intron, an exon thereof or a fragment or combination thereof. The BRCA1 DNA may be hybridized to an oligonucleotide probe, primer or polynucleotide and still be considered “isolated”. The DNA sequence must contain at least one mutation from the list provided in TABLES 3-7. Preferably, the isolated DNA sequence contains a sequence complementary to at least one of the oligonucleotides complementary to the mutations listed in TABLES 3-7. However, the DNA sequence may contain the DNA sequence of these oligonucleotides. This sequence alone has usefulness or after cloning and expression to determine suitable treatments to prevent formation of a tumor, prevent transmission of the mutant gene to offspring or to decide other prophylactic, diagnostic and treatment protocols. The isolated DNA sequence may also be used for drug design by protein replacement, protein mimetics, screening known and unknown compounds, anti-idiotype antibodies to the BRCA1 active site, for the preparation of an immunogen or vaccine and determining appropriate gene therapy to counter the pathology associated with the mutant BRCA1 gene. For diagnostic purposes, knowing the mutant BRCA1 sequence for comparison purposes is the critical step in diagnosis.  
       [0097] Another method comprises contacting a target nucleic acid of a sample from a subject with a reagent that detects the presence of the mutation and detecting the mutation. A number of hybridization methods are well known to those skilled in the art. Many of them are useful in carrying out the invention.  
       [0098] The materials for use in the method of the invention are also ideally suited for the preparation of a diagnostic kit. Such a kit may comprise a carrier means being compartmentalized to receive in close confinement one or more container means such as vials, tubes, and the like, each of the container means comprising one or more of the separate elements to be used in the method. For example, one of the container means may comprise means for amplifying BRCA1 DNA, said means comprising the necessary enzyme(s) and oligonucleotide primers for amplifying said target DNA from the subject. Another container may contain oligonucleotide probes for detecting the presence or absence of a mutation.  
       [0099] The oligonucleotide primers include primers having a sequences referenced above or primer sequences substantially complementary or substantially homologous thereto. Other primers flanking the BRCA1 locus or a region containing one of the mutation sites may be used. The target flanking 5′ and 3′ polynucleotide sequence include other oligonucleotide primers for amplifying the BRCA1 locus will be known or readily ascertainable to those of skill in the art. See the GENBANK sequences mentioned above where flanking sequences are given.  
       [0100] Oligonucleotide probes including probes having substantially the sequence complementary to the mutations listed in TABLES 3-7 or complementary sequences are useful. Other oligonucleotide probes which hybridize to one or more of the BRCA1 mutation sites and sequences substantially complementary or homologous thereto may be used. Other oligonucleotide probes for detecting the mutations will be known or readily ascertainable to those of skill in the art.  
       [0101] The following definitions are provided for the purpose of understanding this invention.  
       [0102] The term “primer” as used herein refers to a sequence comprising two or more deoxyribonucleotides or ribonucleotides, preferably more than three, and more preferably more than eight and most preferably at least 20 nucleotides of the BRCA1 gene wherein the sequence corresponds to a sequence flanking one of the mutations or wild type sequences of BRCA1 corresponding to the mutation sites. Primers may be used to initiate DNA synthesis via the PCR. Oligonucleotides of the present invention can be used for primer hybridization and others will be known or readily ascertainable to those of skill in the art.  
       [0103] The term “substantially complementary to” or “substantially the sequence” refers to sequences which hybridize to the sequences provided under stringent conditions and/or sequences having sufficient homology with, such that the allele specific oligonucleotides of the invention hybridize to the sequence.  
       [0104] “Isolated” as used herein refers to being substantially free of other proteins, lipids, carbohydrates or other materials with which they may be associated. It also refers to being substantially free of polynucleic acids being covalently bound thereto. A DNA may be hybridized to another DNA and still be considered “isolated”, such as being hybridized to a solid phase bound or labeled oligonucleotide probe. Such association is typically either in cellular material or in a synthesis medium.  
       [0105] “Biological sample” refers to a polynucleotide containing sample originally from a biological source. The sample may be from a living, dead, paraffin-embedded tumor specimen or even archeological source from a variety of tissues and cells. Examples include: body fluid [blood (leukocytes), urine (epithelial cells), saliva, cervical and vaginal secretions, milk . . . ] skin, hair roots/follicle, mucus membrane (e.g. buccal or tongue cell scrapings), cervicovaginal cells (from PAP smear, etc.) internal tissue (normal or tumor), chorionic villus tissue, amniotic cells, placental cells, fetal cells, cord blood, sperm or egg.  
       [0106] “Coding sequence” or “DNA coding sequence” refers to those portions of a gene which, taken together, code for a peptide (protein), or for which the nucleic acid itself has function. The DNA coding sequence generally encodes the “complete” protein which is one which has the same biological activity as the naturally occurring BRCA1 protein.  
       [0107] A “target polynucleotide” refers to the nucleotide sequence of interest e.g., the BRCA1 encoding polynucleotide. The nucleotides may be deoxyribonucleotides, ribonucleotides, acyclic derivatives and other functional equivalents such as spacer molecules (inosine, the sugar moiety without a base, etc.) and other molecules which are incorporated by a RNA polymerase, a DNA polymerase or a reverse transcriptase.  
       [0108] “Consensus” means the most commonly occurring in the population.  
       [0109] As used herein, a nucleic acid molecule is the “complement” of another nucleic acid molecule if it exhibits complete complementarity. As used herein, molecules are said to exhibit a “complete complementarity” when every nucleotide of one of the molecules is complementary to a nucleotide of the other. Two molecules are said to be “substantially complementary” if they can hybridize to one another with sufficient stability to permit them to remain annealed to one another under at least conventional “high-stringency” conditions. Similarly, the molecules are said to be “partially complementary” if they can hybridize to one another with sufficient stability to permit them to remain annealed to one another under conventional “low-stringency” conditions. Conventional stringency conditions are described, for example, by Sambrook, J., et al., (In: Molecular Cloning, a Laboratory Manual, 2nd Edition, Cold Spring Harbor Press, Cold Spring Harbor, N.Y. (1989)), and by Haymes, B. D., et al. (In: Nucleic Acid Hybridization, A Practical Approach, IRL Press, Washington, D.C. (1985)), both herein incorporated by reference).  
       [0110] As used herein, an oligonucleotide is said to be capable of “specifically hybridizing” to a complementary target polynucleotide if the two molecules are capable of forming an anti-parallel, double-stranded nucleic acid structure under stringent hybridization conditions, whereas the oligonucleotide is substantially unable to form such a structure when incubated under the same conditions with a target polynucleotide to which the oligonucleotide is not substantially complementary.  
       [0111] “Sequence variation” as used herein refers to any difference in nucleotide sequence between two different oligonucleotide or polynucleotide sequences.  
       [0112] “Polymorphism” as used herein refers to a sequence variation in a gene which is not necessarily associated with pathology.  
       [0113] “Mutation” as used herein refers to an altered genetic sequence which results in the gene coding for a non-functioning protein or a protein with substantially reduced or altered function. Generally, a deleterious mutation is associated with pathology or the potential for pathology. The mutations in the present invention usually involve non-sense and frame shift mutations which cause a truncated (and presumably non-functional) protein to be formed. These truncations are at the terminus of the protein rather than a deletion of one or more amino acids in an internal, non-terminal region of the BRCA1 protein.  
       [0114] The “mutation site” is the location of the added, deleted or substituted bases in the wild-type or consensus BRCA1 DNA sequence which describes the mutant BRCA1 DNA sequence.  
       [0115] “Predetermined sequence variation” as used herein refers to a nucleotide sequence that is designed to be different than the corresponding sequence in a reference nucleotide sequence. A predetermined sequence variation can be a known mutation in a BRCA1 gene.  
       [0116] “BRCA1 gene” refers the published gene sequences, such as those appearing in the GENBANK database under Accession Number, 159546, 2489823, and Y08757. Other different sequences which include polymorphisms and genetic alterations, particularly those which don&#39;t cause an amino acid change or which are naturally occurring (wild types), which are not associated with pathology are also considered the BRCA1 gene. The corresponding nucleotides would then be used even if the nucleotide number differs. Generally, the sense strand is referred to. The BRCA1 gene may be in fragments. “Fragments” are segments of the BRCA1 gene, generally about 15 or more nucleotides in length, usually a few hundred or more nucleotides in length and potentially containing the particular mutation site of interest. The complementary strand to the sense strand of the BRCA1 gene (the so-called antisense strand) is also considered the “BRCA1 gene”. While the BRCA1 gene discussed herein is the human BRCA1 gene, the corresponding assays and reagents for the gene in other animals may also be used. The BRCA1 gene includes the coding sequences, non-coding sequences (e.g. introns) and regulatory regions affecting gene expression.  
       [0117] “Allele specific detection assay” as used herein refers to an assay to detect the presence or absence of a predetermined sequence variation in a test polynucleotide or oligonucleotide by annealing the test polynucleotide or oligonucleotide with a polynucleotide or oligonucleotide of predetermined sequence such that differential DNA sequence based techniques or DNA amplification methods discriminate between normal and mutant. Allele Specific Oligonucleotide hybridization is sometimes referred to ASO or the ASO method.  
       [0118] “Sequence variation locating assay” as used herein refers to an assay that detects a sequence variation in a test polynucleotide or oligonucleotide and localizes the position of the sequence variation to a sub-region of the test polynucleotide, without necessarily determining the precise base change or position of the sequence variation.  
       [0119] “Targeted confirmatory sequencing” as used herein refers to sequencing a polynucleotide in the region wherein a sequence variation has been located by a sequence variation locating assay in order to determine the precise base change and/or position of the sequence variation.  
       [0120] “Probe” includes any oligonucleotide which hybridizes to a BRCA1 or mutant BRCA1 sequence. The probe may be labeled (directly or indirectly) or it may act as a primer such as a PCR primer.  
       [0121] “Cancer”, “tumor” and “neoplasm” are used interchangeably to refer to certain abnormal cells. The terms are not meant to denote a stage of malignancy.  
       [0122] The invention in several of its embodiments includes:  
       [0123] Detection of Predetermined Sequence Variations  
       [0124] Stage I analysis is used to determine the presence or absence of a predetermined nucleotide sequence variation; preferably a known mutation or set of known mutations in the test gene. In accordance with the invention, such predetermined sequence variations are preferably detected by allele specific hybridization, a sequence-dependent-based technique which permits discrimination between normal and mutant alleles. An allele specific assay is dependent on the differential ability of mismatched nucleotide sequences (e.g., normal:mutant) to hybridize with each other, as compared with matching (e.g., normal:normal or mutant:mutant) sequences.  
       [0125] Detection of Predetermined Sequence Variations Using Allele Specific Hybridization  
       [0126] A variety of methods well-known in the art can be used for detection of predetermined sequence variations by allele specific hybridization. Preferably, the test gene is probed with allele specific oligonucleotides (ASOs); and each ASO contains the sequence of a known mutation. ASO analysis detects specific sequence variations in a target polynucleotide fragment by testing the ability of a specific oligonucleotide probe to hybridize to the target polynucleotide fragment. Preferably, the oligonucleotide contains the mutant sequence (or its complement). The presence of a sequence variation in the target sequence is indicated by hybridization between the oligonucleotide probe and the target fragment under conditions in which an oligonucleotide probe containing a normal sequence does not hybridize to the target fragment. A lack of hybridization between the sequence variant (e.g., mutant) oligonucleotide probe and the target polynucleotide fragment indicates the absence of the specific sequence variation (e.g., mutation) in the target fragment. In a preferred embodiment, the test samples are probed in a standard dot blot format. Each region within the test gene that contains the sequence corresponding to the ASO is individually applied to a solid surface, for example, as an individual dot on a membrane. Each individual region can be produced, for example, as a separate PCR amplification product using methods well-known in the art (see, for example, the experimental embodiment set forth in Mullis, U.S. Pat. No. 4,683,202). The use of such a dot blot format is described in detail in the Examples below, detailing the Stage I analysis of the human BRCA1 gene to detect the presence or absence of different known mutations using corresponding ASOs.  
       [0127] Membrane-based formats that can be used as alternatives to the dot blot format for performing ASO analysis include, but are not limited to, reverse dot blot, MAD (multiplex amplification assay), and multiplex allele-specific diagnostic assay (MASDA).  
       [0128] In a reverse dot blot format, oligonucleotide or polynucleotide probes having known sequence are immobilized on the solid surface, and are subsequently hybridized with the labeled test polynucleotide sample. In this situation, the primers may be labeled or the NTPs maybe labeled prior to amplification to prepare a labeled test polynucleotide sample. Alternatively, the test polynucleotide sample may be labeled subsequent to isolation and/or synthesis.  
       [0129] In a multiplex format, individual samples contain multiple target sequences within the test gene, instead of just a single target sequence. For example, multiple PCR products each containing at least one of the ASO target sequences are applied within the same sample dot. Multiple PCR products can be produced simultaneously in a single amplification reaction using the methods of Caskey et al., U.S. Pat. No. 5,582,989. The same blot, therefore, can be probed by each ASO whose corresponding sequence is represented in the sample dots.  
       [0130] A MASDA format expands the level of complexity of the multiplex format by using multiple ASOs to probe each blot (containing dots with multiple target sequences). This procedure is described in detail in U.S. Pat. No. 5,589,330 by A. P. Shuber, and in Michalowsky et al.,  American Journal of Human Genetics,  59(4): A272, poster 1573 (October 1996), each of which is incorporated herein by reference in its entirety. First, hybridization between the multiple ASO probe and immobilized sample is detected. This method relies on the prediction that the presence of a mutation among the multiple target sequences in a given dot is sufficiently rare that any positive hybridization signal results from a single ASO within the probe mixture hybridizing with the corresponding mutant target. The hybridizing ASO is then identified by isolating it from the site of hybridization and determining its nucleotide sequence.  
       [0131] Suitable materials that can be used in the dot blot, reverse dot blot, multiplex, and MASDA formats are well-known in the art and include, but are not limited to nylon and nitrocellulose membranes.  
       [0132] When the target sequences are produced by PCR amplification, the starting material can be chromosomal DNA in which case the DNA is directly amplified. Alternatively, the starting material can be mRNA, in which case the mRNA is preferably first reversed transcribed into cDNA and then amplified according to the well known technique of RT-PCR (see, for example, to U.S. Pat. No. 5,561,058 by Gelfand et al.).  
       [0133] The methods described above are suitable for moderate screening of a limited number of sequence variations. However, with the need in molecular diagnosis for rapid, cost effective large scale screening, technologies have developed that integrate the basic concept of ASO, but far exceed the capacity for mutation detection and sample number. These alternative methods to the ones described above include, but are not limited to, large scale chip array sequence-based techniques. The use of large scale arrays allows for the rapid analysis of many sequence variants. A review of the differences in the application and development of chip arrays is covered by Southern,  Trends In Genetics,  12: 110-115 (March 1996) and Cheng et al.,  Molecular Diagnosis,  1:183-200 (Sept. 1996). Several approaches exist involving the manufacture of chip arrays. Differences include, but not restricted to: type of solid support to attach the immobilized oligonucleotides, labeling techniques for identification of variants and changes in the hybridization of the target polynucleotide to the probe.  
       [0134] A promising methodology for large scale analysis on “DNA chips” is described in detail in Hacia et al.,  Nature Genetics,  14:441-447 (1996), which is hereby incorporated by reference in its entirety. As described in Hacia et al., high density arrays of over 96,000 oligonucleotides, each 20 nucleotides in length, are immobilized to a single glass or silicon chip using light directed chemical synthesis. Contingent on the number and design of the oligonucleotide probe, potentially every base in a sequence can be interrogated for alterations. Oligonucleotides applied to the chip, therefore, can contain sequence variations that are not yet known to occur in the population, or they can be limited to mutations that are known to occur in the population.  
       [0135] Prior to hybridization with oligonucleotide probes on the chip, the test sample is preferably isolated, amplified and labeled (e.g. fluorescent markers) by means well known to those skilled in the art. The test polynucleotide sample is then hybridized to the immobilized oligonucleotides. The intensity of hybridization of the target polynucleotide to the immobilized probe is quantitated and compared to a reference sequence. The resulting genetic information can be used in molecular diagnosis.  
       [0136] A common, but not limiting, utility of the “DNA chip” in molecular diagnosis is screening for known mutations. However, this may impose a limitation to the technique by only looking at mutations that have been described in the field. The present invention allows allele specific hybridization analysis be performed with a far greater number of mutations than 1b previously available. In accordance with the present invention, DNA chips may be constructed with any number of ASO&#39;s specific for any number of mutations of the present invention. Such DNA chips may include hundreds, thousands, or more different ASO&#39;s, optionally enabling the screening for all possible mutations of the present invention in a single DNA chip. Preferably, DNA chips of the present invention contain about 10 to about 1000, about 100 to about 1,000, about 1,000 to about 10,000, about 10,000 to about 10,0000, or even greater than 100,000 allele specific oligonucleotides specific for the mutations of the present invention. Additionally, such a DNA chip may optionally contain ASO&#39;s specific for those missense mutations for which a clinical significance has been established and/or ASO&#39;s specific for wild-type BRCA1 DNA sequences. Thus, the efficiency and comprehensiveness of large scale ASO analysis will be broadened, reducing the need for cumbersome end-to-end sequence analysis, not only with known mutations but in a comprehensive manner all mutations which might occur as predicted by the principles accepted, and the cost and time associated with these cumbersome tests will be decreased. 
     
    
    
     EXAMPLE  
     [0137] Genomic DNA (at least about 100 ng) is isolated from white blood cells of a subject with a family history of various cancer. Genomic DNA (at least about 100 ng) is also isolated from a wide variety of fresh tumor cells from biopsy, frozen tumor tissue previously surgically removed and tumor cell lines. Dideoxy sequence analysis is performed following polymerase chain reaction amplification of the BRCA1 gene. The primers are the same as used in the references above.  
     [0138] Each segment of the BRCA1 gene is subjected to direct dideoxy sequence analysis by asymmetric amplification using the polymerase chain reaction (PCR) to generate a single stranded product amplified from this DNA sample. Shuldiner, et al., Handbook of Techniques in Endocrine Research, p. 457-486, DePablo, F., Scanes, C., eds., Academic Press, Inc., 1993. Fluorescent dye is attached for automated sequencing using the TAQ DYE TERMINATOR KIT (PERKIN-ELMER cat# 401628). DNA sequencing is performed in both forward and reverse directions on an APPLIED BIOSYSTEMS, INC. (ABI) automated sequencer (Model 377). The software used for analysis of the resulting data is ASEQUENCE NAVIGATOR@ purchased through ABI.  
     [0139] The methods of the invention, which can be used to detect sequence variations in any polynucleotide sample, are demonstrated in the Example set forth in this section, for the purpose of illustration, for one gene in particular, namely, the human BRCA1 gene. The BRCA1 coding sequence is approximately 5592 base pairs encoding the 403 amino acids BRCA1 protein.  
     [0140] Designing an Allele Specific Oligonucleotide (ASO) Probe  
     [0141] An allele specific oligonucleotide probe is a short, single stranded polynucleotide that is engineered to hybridize exactly to a target sequence under a given set of conditions. Routinely, ASO probes are designed to contain sequences identical to the normal allele and sequence variation respectively. Hybridization of the probe to the target allows for the discrimination of a variant sample. Under stringent conditions, a probe with a variation as simple as a single-base pair will not hybridize to a normal sequence due to a destabilizing effect of the normal-mutant duplex (Ikuta, S. et al,  Nucleic Acids Research,  15: 797-811 (1987). For use in this invention, probes are used to discriminate between a wild-type or normal sequence from one that is mutated. Each probe pair contains a polynucleotide sequence that encompassed an area that would identify a selected mutation of the BRCA1 gene.  
     [0142] The design of an ASO hybridization probe must meet two basic requirements. ( Current Protocols in Human Genetics,  9.4, (1995)). First, probes that are used together in the same pool should be around the same length. Although the standard length of a probe is optimally about 17 base pairs, the range can be as short as about 13 or as long as 30 or more. If the mutation contains a long insertion, a longer probe may be desirable. Second, the mismatched region should not be placed at the end of the probe, but approximately in the middle of the sequence. In addition, the placement of a mismatch, in the case of a longer probe, should not be at the end, but at a position that allows strong hybridization and stabilization of the polynucleotide strand. In order to minimize the effects of variations in base composition of the probes, tetramethylammonium chloride may be used as in the ASO hybrid&#39;s buffer (Shuber, U.S. Pat. No. 5,633,134). Conventionally, ASO probes are synthesized on a DNA synthesizer. They can be labeled with isotopic or non-isotopic detection agents using means familiar to those of skill in the art. The process outlined in this application for making and using probes can be applicable for other gene sequences.  
     [0143] Protein Truncation Assay  
     [0144] PCR Amplification  
     [0145] BRCA1 is first amplified by PCR from a patient sample using one or more primer sets. A single set of primers may be used to amplify the entire BRCA1 gene or multiple sets of primers may be used. Preferably one need not use a separate set of primers for each exon because the protein expression products are so small that detecting a truncation will be difficult.  
     [0146] Using the primer sets referenced above in a reaction containing Ex Taq Buffer 10×5.0 mL, dNTP&#39;s 2.5 mM 4.0 mL, Forward primer 10 mM 1.0 mL, Reverse primer 10 mM 1.0 mL, TaKaRa Ex Taq (Oncor RR001B) 2.5 U 1.0 mL, Template DNA 100 ng/mL 1.0 mL and OmniPure dH2O to 50 mL final volume. One DNA control (placental DNA), one positive control reaction and three no template control reactions are included for each sample batch.  
     [0147] PCR for the BRCA1 gene is performed using the following thermocycling conditions (4 linked programs):  
                                                       Temperature   Time   #of Cycles                          94° C.   5 min.   1           94° C. 55° C. 72° C.   30 sec. 1 min. 3 min.                          35           72° C.   5 min.   1            4° C.   hold   1                      
 
     [0148] 5 m\μL of the PCR product is placed on a 2% agarose gel. On the same gel a DNA 100 BP LADDER (Gibco BRL 15628-019) and a low DNA MASS LADDER (Gibco BRL 10068-013) is placed to verify product size.  
     [0149] The resulting product is analyzed according to the following rules: l)Each patient sample must show a band of the correct size. If a patient sample demonstrates smearing or multiple bands, the PCR reaction needs to be repeated (no more than three times) until a clean, single band is detected. If no PCR product is visible or if only a weak band is visible, but the placental DNA sample worked well, the sample is reamplified with twice as much template. The volume of the reaction is adjusted appropriately.  
     [0150] All “No template” (2-3) reactions must not show amplification products of any size. If any one shows any contamination (i.e. specific amplification product), all PCR products should be thrown away and the entire PCR set-up should be repeated after appropriate PCR decontamination procedures have been taken.  
     [0151] The intensity of the patient sample PCR product is compared with that of the DNA 100 bp ladder. The optimum amount of PCR product on the gel should be 50-100 ng. If less than this is present or if the intensity of the patient sample is less than half the intensity of the placental control sample, repeat the PCR reaction until sufficient quantity is obtained. If no PCR product is visible or if only a weak band is visible, but the placental DNA sample worked well, the patient sample is reamplified with twice as much template DNA.  
     [0152] The PCR product is precipitated by adding the following to each tube: 3M sodium acetate 30 μL, 20 mg/mL glycogen 2 μL, dH2O 178 μL, and PCR product 90 μL. The reaction is mixed by inverting the tubes 4-6 times. 600 μL of 100% ethanol (200 proof) is added to each tube and the reaction can be placed at −20° C. overnight. The following day, samples are allowed to equilibrate to room temperature before proceeding. The tubes are centrifuged at 13,000 rpm for 15 minutes at room temperature in an IEC microcentrifuge. The supernatant is removed leaving a pellet. 1 mL cold 70% ethanol is added to each tube and centrifuged at 13,000 rpm for 5 minutes at room temperature in the IEC microcentrifuge. The supernatant is again removed leaving the pellet. The tubes are dried by vacuum for 10-15 minutes until no ethanol remains in the tube. Redissolve the pellet in 10 μL of dH2O.  
     [0153] 1 mL of the PCR product is electrophoresed on a 2% TAE agarose gel, in parallel with a DNA 100 bp ladder and a DNA mass ladder to verify product size and amount of product. The mass of the 1 μL purified PCR product is estimated using the DNA mass ladder as a reference. The band equals one-tenth of the total quantity of purified PCR product. The amount required for the lysate reaction is between 500-750 ng. For example, if the band is the intensity of the 100 ng marker, then the amount needed for the lysate reaction is 5.0-7.5 μL of purified PCR product. If there is less than 500 ng total, the PCR must be repeated.  
     [0154] In vitro transcription/translation  
     [0155] This procedure is performed using the TnT Coupled Reticulocyte Lysate system from Promega L4610. Each kit contains the reagents necessary for 80 25 μL translation reactions. This kit allows the synthesis of the specified protein from PCR product.  
     [0156] The TnT Rabbit Reticulocyte Lysate is thawed in gloved hands and immediately place on ice. The TnT T7 RNA Polymerase and RNase Inhibitor (Boehringer Mannheim 799025) are placed on ice at all times. Solutions are mixed in the following order in a 0.5 mL microcentrifuge tube. Rabbit Reticulocyte Lysate 12.5 μL, TnT Reaction buffer 1.0 μL, TnT T7 RNA Polymerase 0.5 μL, Amino Acid Mixture minus Met (1 mM) 0.5 μL, RNase inhibitor 0.5 μL, per 15.0 ml sample.  
     [0157] The following are added to a clean labeled 0.5 mL microcentrifuge tube for each reaction: master mix 15.0 μL, 35S methionine (Amersham SJ1015) (1 mCi/100 μL) 2.0 μL, DNA template (500-750 ng) per μL, sdH2O to 25 μL final volume. The reactions are placed in the 30° C. water bath for 1.5 hours.  
     [0158] Gel Preparation, Run and Handling  
     [0159] Pre-run the gel (15% Tris-glycine Ready gel (15 well) BioRad 161-0938 or (10 well) BioRad 161-0908) in a Mini Protean II Gel apparatus (BioRad 165-2941) for 15 minutes to equilibrate the gel with the SDS from the running buffer (10×Tris/Glycine/SDS, BioRad 161-0732). Load samples and check the buffer volume during the course of the run to assure that nothing has leaked out. Decreased buffer volume in the middle chamber will interfere with the current. Monitor the progress of the gel running to prevent the lower marker (blue band) from running off the gel. The average running time is 3 hours.  
     [0160] The gel is rinsed with dH2O after fixing the gel to remove excess salicylic acid and oriented. A mixture of 5.26 mL of beta-mercaptoethanol (BioRad 161-0710) and 94.74 mL of Laemelli sample buffer (BioRad 161-0737) was prepared. The 35S ladder is added as follows in a labeled, 0.5 mL microcentrifuge tube: 7 kD marker in 5 μL, 11 kD marker in 5 μL, 25 kD marker in 2 μL, 74 kD marker in 2 μL. A second labeled tube completes the 35S ladder with: combined lysate 14 μL, sample buffer 32 μL, 100 μM IAA 12 μL, sdH2O 22 mL with a total of 20 μL per gel.  
     [0161] In a 0.5 μL microcentrifuge tube, the following is added:  
     [0162] 2 μL lysate reaction, 8 μL sample buffer, 4 μL 100 mM IAA, 6 μL sdH2O, to a total load volume of 20 μL. The samples are heated at 95° C. for 3 minutes and then placed on ice for 2 minutes before loading gel. For every gel run, the following controls are included:  
     [0163] a. 10 μL of Broad Range Prestained SDS-PAGE standard (BioRad 161-0318) heated to 37° C. to dissolve any precipitated material.  
     [0164] b. 35S ladder  
     [0165] c. one negative control per sample  
     [0166] d. one positive control specific to the fragment under analysis  
     [0167] During the first 20 minutes, the samples are run at 10 mA (20 mA for two gels). This allows the protein to migrate through the resolving gel at a slower rate. After 20 minutes, the current is increased to 20 mA (40 mA for two gels) for the remainder of the gel run. The buffer volume is checked during the course of the run to assure that nothing has leaked out. Decreased buffer volume in the middle chamber will interfere with the current. The average running time is 3 hours. The lower marker on the polypeptide standard is 7.1 kD (blue band) and should not run off the gel.  
     [0168] After running the gel, the plastic adhesive is removed from the back of the ready gel and gently peel off the top plate. The gel will remain attached to the back plate. The gel is placed in fixative solution of Isopropanol 250 mL, sdH2O 650 mL and acetic acid 100 mL in a volume sufficient to cover gel for 15 minutes with swirling the gel occasionally by hand or on a rotating plate. The gel is then placed in a fluorogenic agent of salicylic acid 160 g and sdH2O to 1 L final volume, pH adjusted to pH 6.0, in a volume sufficient to cover gel for 15 minutes with swirling the gel occasionally by hand or on a rotating plate. The gel is then rinsed with sdH2O to remove any excess salicylic acid.  
     [0169] The gel is dried by sandwiching it between two sheets of cellophane and drying it in a gel dryer (BioRad 165-1771) for 1.5-2.5 hours. The dried gel is removed, placed in a film cassette (Fisher IB1502350) taped to a piece of film (Kodak BioMax MR Sigma 870-1302) over the dried gel(s), oriented with Identi-kit tape (Diversified Biotech ID-100) and exposed for 3-5 XD hours at −80° C. The film may be exposed overnight at −20° C. or over the weekend at room temperature if needed.  
     [0170] Patient samples are compared to the normal genomic DNA fragments. Truncated proteins are possible at any point along the sequence. Therefore, a shift in bands located in any patient sample is an indication of a mutation. There are areas in the sequence where a mutation can occur that are difficult to detect because of the small molecular weight protein formed by the truncation or because a stop signal occurs at the end of the sequence. These mutations are scanned for as follows. The base pairs at the 5′ end of BRCA1 are sequenced. This assures the ability to detect, by means of sequencing, proteins 10 kD or less and the ability to detect, by means of protein truncation, anything greater than 10 kD. A mutation causing a stop codon to occur at the end of the BRCA1 gene is identified by sequencing the final 257 base pairs.  
     [0171] The truncated BRCA1 protein should be of equal intensity on the gel as the normal BRCA1 protein. When a potential truncated band is identified, the protein must be sized using the 35S radiolabeled marker. For example, if a band appears to be in the area of the 50 kD marker, then the range of inspection for the mutation is between 40-50 kD. The position of the stop signal does not always indicate the position where the mutation occurred. Using the following conversion factor: 270 bp=10 kD, the molecular weight can be converted into base pairs.  
     [0172] Detailed Method for the Detection of Sequence Variations in Polynucleotides  
     [0173] Isolation of Genomic DNA  
     [0174] White blood cells are collected from the patients and genomic DNA is extracted from the white blood cells according to well-known methods (Sambrook, et al., Molecular Cloning, A Laboratory Manual, 2nd Ed., 1989, Cold Spring Harbor Laboratory Press, at 9.16-9.19). Genomic DNA is similarly extracted from a wide variety of fresh tumor cells from biopsy, frozen tumor tissue previously surgically removed and tumor cell lines.  
     [0175] PCR Amplification for Sequencing  
     [0176] The genomic DNA is used as a template to amplify a DNA fragment encompassing the site of the mutation to be tested. The 25 μl PCR reaction contains the following components: 1 μl template (100 ng/ ml) DNA, 2.5 μl 10×PCR Buffer (PERKIN-ELMER), 1.5 μl dNTP (2 mM each dATP, dCTP, dGTP, dTTP), 1.5 μl Forward Primer (10 mM), 1.5 μl Reverse Primer (10 mM), 0.5 μl (2.5 U total) AMPLITAQ GOLD™ TAQ DNA POLYMERASE or AMPLITAQ7 TAQ DNA POLYMERASE (PERKIN-ELMER), 1.0 to 5.0 μl (25 mM) MgCl 2  (depending on the primer) and distilled water (dH 2 O) up to 25 μl. All reagents for each exon except the genomic DNA can be combined in a master mix and aliquoted into the reaction tubes as a pooled mixture.  
     [0177] For each exon analyzed, the following control PCRs are set up:  
     [0178] (1) “Negative” DNA control (100 ng placental DNA (SIGMA CHEMICAL CO., St. Louis, Mo.)  
     [0179] (2) Three “no template” controls  
     [0180] PCR for all exons is performed using the following thermocycling conditions:  
                                                       Temperature   Time   Number of Cycles                          90° C.   5 min. (AMPLITAQ)   1           or   10 min. (GOLD)                                                 95° C. 55° C. 72° C.   30 sec. 30 sec. 1 min.                          30 cycles                       72° C.   5 min.       1           4° C.   hold       1                      
 
     [0181] Quality Control Agarose Gel of PCR Amplification:  
     [0182] The quality of the PCR products is examined prior to further analysis by electrophoresing an aliquot of each PCR reaction sample on an agarose gel. 5 μl of each PCR reaction is run on an agarose gel along side a DNA 100 BP DNA LADDER (Gibco BRL cat# 15628-019). The electrophoresed PCR products are analyzed according to the following criteria:  
     [0183] Each patient sample must show a single band of the size corresponding the number of base pairs expected from the length of the PCR product from the forward primer to the reverse primer. If a patient sample demonstrates smearing or multiple bands, the PCR reaction must be repeated until a clean, single band is detected. If no PCR product is visible or if only a weak band is visible, but the control reactions with placental DNA template produced a robust band, the patient sample should be re-amplified with 2×as much template DNA.  
     [0184] All three “no template” reactions must show no amplification products. Any PCR product present in these reactions is the result of contamination. If any one of the “no template” reactions shows contamination, all PCR products should be discarded and the entire PCR set of reactions should be repeated after the appropriate PCR decontamination procedures have been taken.  
     [0185] The optimum amount of PCR product on the gel should be between 50 and 100 ng, which can be determined by comparing the intensity of the patient sample PCR products with that of the DNA ladder. If the patient sample PCR products contain less than 50 to 100 ng, the PCR reaction should be repeated until sufficient quantity is obtained.  
     [0186] DNA Sequencing  
     [0187] For DNA sequencing, double stranded PCR products are labeled with four different fluorescent dyes, one specific for each nucleotide, in a cycle sequencing reaction. With Dye Terminator Chemistry, when one of these nucleotides is incorporated into the elongating sequence it causes a termination at that point. Over the course of the cycle sequencing reaction, the dye-labeled nucleotides are incorporated along the length of the PCR product generating many different length fragments.  
     [0188] The dye-labeled PCR products will separate according to size when electrophoresed through a polyacrylamide gel. At the lower portion of the gel on an ABI automated sequencer, the fragments pass through a region where a laser beam continuously scans across the gel. The laser excites the fluorescent dyes attached to the fragments causing the emission of light at a specific wavelength for each dye. Either a photomultiplier tube (PMT) detects the fluorescent light and converts is into an electrical signal (ABI 373) or the light is collected and separated according to wavelength by a spectrograph onto a cooled, charge coupled device (CCD) camera (ABI 377). In either case the data collection software will collect the signals and store them for subsequent sequence analysis.  
     [0189] PCR products are first purified for sequencing using a QIAQUICK-SPIN PCR PURIFICATION KIT (QIAGEN #28104). The purified PCR products are labeled by adding primers, fluorescently tagged dNTPs and Taq Polymerase FS in an ABI Prism Dye Terminator Cycle Sequencing Kit (PERKIN ELMER/ABI catalog #02154) in a PERKIN ELMER GENEAMP 9600 thermocycler.  
     [0190] The amounts of each component are:  
                                                          For Samples       For Controls                                         Reagent   Volume   Reagent   Volume                       Dye mix   8.0 μL   PGEM   2.0 μL           Primer (1.6 mM)   2.0 μL   M13   2.0 μL           PCR product   2.0 μL   Dye mix   8.0 μL           sdH2O   8.0 μL   sdH2O   8.0 μL                      
 
     [0191] The thermocycling conditions are:  
                                                       Temperature   Time   # of Cycles                                                                                    96° C. 50° C. 60° C.   15 sec. 5 sec. 4 min.                          25                       4° C.   hold       1                      
 
     [0192] The product is then loaded into a gel and placed into an ABI DNA Sequencer (Models 373A &amp; 377) and run. The sequence obtained is analyzed by comparison to the wild type (reference) sequence using SEQUENCE NAVIGATOR software. When a sequence does not align, it indicates a possible mutation. The DNA sequence is determined in both the forward and reverse directions. All results are provided to a second reader for review.  
     [0193] Heterozygous/homozygous point mutations and polymorphisms must be seen in both strands. Frame shift mutations will be seen in both strands and must have clear double peaks in frame shift regions to be so identified.  
     [0194] PCR Amplification for ASO  
     [0195] The genomic DNA is used as a template to amplify a separate DNA fragment encompassing the site of the mutation to be tested. The 50 ml PCR reaction contains the following components: 1 ml template (100 ng/ ml) DNA, 5.0 ml 10×PCR Buffer (PERKIN-ELMER), 2.5 ml dNTP (2 mM each dATP, dCTP, dGTP, dTTP), 2.5 ml Forward Primer (10 mM), 2.5 ml Reverse Primer (10 mM), 0.5 ml (2.5 U total) AMPLITAQ7 TAQ DNA POLYMERASE or AMPLITAQ GOLD™ DNA POLYMERASE (PERKIN-ELMER), 1.0 to 5.0 ml (25 mM) MgCl 2  (depending on the primer) and distilled water (dH 2 O) up to 50 ml. All reagents for each exon except the genomic DNA can be combined in a master mix and aliquoted into the reaction tubes as a pooled mixture.  
     [0196] For each exon analyzed, the following control PCRs are set up:  
     [0197] (1) “Negative” DNA control (100 ng placental DNA (SIGMA CHEMICAL CO., St. Louis, Mo.)  
     [0198] (2) Three “no template” controls  
     [0199] PCR for all exons is performed using the following thermocycling conditions:  
                                                       Temperature   Time   Number of Cycles                          95° C.   5 min. (AMPLITAQ)   1               or 10 min. (GOLD)                                                             95° C. 55° C. 72° C.   30 sec. 30 sec. 1 min.                          30 cycles                       72° C.   5 min.       1           4° C.   hold       1                      
 
     [0200] The quality control agarose gel of PCR amplification is performed as above.  
     [0201] Binding PCR Products to Nylon Membrane  
     [0202] The PCR products are denatured no more than 30 minutes prior to binding the PCR products to the nylon membrane. To denature the PCR products, the remaining PCR reaction (45 ml) and the appropriate positive control mutant gene amplification product are diluted to 200 ml final volume with PCR Diluent Solution (500 mM NaOH, 2.0 M NaCl, 25 mM EDTA) and mixed thoroughly. The mixture is heated to 95° C. for 5 minutes, and immediately placed on ice and held on ice until loaded onto dot blotter, as described below.  
     [0203] The PCR products are bound to 9 cm by 13 cm nylon ZETA PROBE BLOTTING MEMBRANE (BIO-RAD, Hercules, Calif., catalog number 162-0153) using a BIO-RAD dot blotter apparatus. Forceps and gloves are used at all times throughout the ASO analysis to manipulate the membrane, with care taken never to touch the surface of the membrane with bare hands or latex gloves.  
     [0204] Pieces of 3 MM filter paper [WHATMAN7, Clifton, N.J.] and nylon membrane are pre-wet in 10×SSC prepared fresh from 20×SSC buffer stock. The vacuum apparatus is rinsed thoroughly with dH 2 O prior to assembly with the membrane. 100 ml of each denatured PCR product is added to the wells of the blotting apparatus. Each row of the blotting apparatus contains a set of reactions for a single exon to be tested, including a placental DNA (negative) control, a synthetic oligonucleotide with the desired mutation or a PCR product from a known mutant sample (positive control), and three no template DNA controls.  
     [0205] After applying PCR products, the nylon filter is placed DNA side up on a piece of 3 MM filter paper saturated with denaturing solution (1.5 M NaCl, 0.5 M NaOH) for 5 minutes. The membrane is transferred to a piece of 3MM filter paper saturated with neutralizing solution (1 M Tris-HCl, pH 8, 1.5 M NaCl) for 5 minutes. The neutralized membrane is then transferred to a dry 3 MM filter DNA side up, and exposed to ultraviolet light (STRALINKER, STRATAGENE, La Jolla, Calif.) for exactly 45 seconds the fix the DNA to the membrane. This UV crosslinking should be performed within 30 min. of the denaturation/neutralization steps. The nylon membrane is then cut into strips such that each strip contains a single row of blots of one set of reactions for a single exon.  
     [0206] Hybridizing Labeled Oligonucleotides to the Nylon Membrane  
     [0207] Prehybridization  
     [0208] The strip is prehybridized at 52° C. incubation using the HYBAID7 (SAVANT INSTRUMENTS, INC., Holbrook, N.Y.) hybridization oven. 2×SSC (15 to 20 ml) is preheated to 52° C. in a water bath. For each nylon strip, a single piece of nylon mesh cut slightly larger than the nylon membrane strip (approximately 1″×5″) is pre-wet with 2×SSC. Each single nylon membrane is removed from the prehybridization solution and placed on top of the nylon mesh. The membrane/mesh “sandwich” is then transferred onto a piece of Parafilm™. The membrane/mesh sandwich is rolled lengthwise and placed into an appropriate HYBAID7 bottle, such that the rotary action of the HYBAID7 apparatus caused the membrane to unroll. The bottle is capped and gently rolled to cause the membrane/mesh to unroll and to evenly distribute the 2×SSC, making sure that no air bubbles formed between the membrane and mesh or between the mesh and the side of the bottle. The 2×SSC is discarded and replaced with 5 ml TMAC Hybridization Solution, which contains 3 M TMAC (tetramethyl ammoniumchloride—SIGMA T-3411), 100 mM Na 3 PO 4  (pH 6.8), 1 mM EDTA, 5× Denhardt&#39;s (1% Ficoll, 1% polyvinylpyrrolidone, 1% BSA (fraction V)), 0.6% SDS, and 100 mg/ml Herring Sperm DNA. The filter strips are prehybridized at 52° C. with medium rotation (approx. 8.5 setting on the HYBAID7 speed control) for at least one hour. Prehybridization can also be performed overnight.  
     [0209] Labeling Oligonucleotides  
     [0210] The DNA sequences of the numerous oligonucleotide probes are used to detect the BRCA1 mutation. For each mutation, a mutant and a normal oligonucleotide must be labeled. While only five pairs of oligonucleotide probes are listed below, corresponding oligonucleotides for each mutation may be prepared and used in a similar manner.  
                                          mutation 185delAG.                   wild-type           5′-AAT CTT AGA GTG TCC CA-3′,   SEQ ID NO:3           mutant           5′-ATC TTA GTG TCC CAC CT-3′,   SEQ ID NO:4                       mutation 1136insA.           wild-type           5′-CAG AAA AAA AGG TAG AT-3′,   SEQ ID NO:5           mutant           5′-CAG AAA AAA AAG GTA GA-3′,   SEQ ID NO:6                       mutation 5383insC.           wild-type           5′-AGA GAA TCC CAG GAC AG-3′,   SEQ ID NO:7           mutant           5′-AGA GAA TCC CCA GGA CA-3′,   SEQ ID NO:8                       mutationC4446T.           wild-type           5′-AGG ACC TGC GAA ATC CA-3′,   SEQ ID NO:9           mutant           5′-AGG ACC TGT GAA ATC CA-3′,   SEQ ID NO:10          
 
     [0211] Each labeling reaction contains 2 ml 5×Kinase buffer (or 1 ml of 10×Kinase buffer), 5 ml gamma-ATP  32 P (not more than one week old), 1 μl T4 polynucleotide kinase, 3 μl oligonucleotide (20 mM stock), sterile H 2 O to 10 μl final volume if necessary. The reactions are incubated at 37° C. for 30 minutes, then at 65° C. for 10 minutes to heat inactivate the kinase. The kinase reaction is diluted with an equal volume (10 μl) of sterile dH 2 O (distilled water).  
     [0212] The oligonucleotides are purified on STE MICRO SELECT-D, G-25 spin columns (catalog no. 5303-356769), according to the manufacturer&#39;s instructions. The 20 μl synthetic oligonucleotide eluate is diluted with 80 μl dH 2 O (final volume=100 μl). The amount of radioactivity in the oligonucleotide sample is determined by measuring the radioactive counts per minute (cpm). The total radioactivity must be at least 2 million cpm. For any samples containing less than 2 million cpm total, the labeling reaction is repeated.  
     [0213] Hybridization with Mutant Oligonucleotides  
     [0214] Approximately 2-5 million cpm of the labeled mutant oligonucleotide probe is diluted into 5 ml of TMAC hybridization solution, containing 40 μl of 20 mM stock of unlabeled normal oligonucleotide. The probe mix is preheated to 52° C. in the hybridization oven. The pre-hybridization solution is removed from each bottle and replaced with the probe mix. The filter is hybridized for 1 hour at 52° C. with moderate agitation. Following hybridization, the probe mix is decanted into a storage tube and stored at −20° C. The filter is rinsed by adding approximately 20 ml of 2×SSC+0.1% SDS at room temperature and rolling the capped bottle gently for approximately 30 seconds and pouring off the rinse. The filter is then washed with 2×SSC+0. 1% SDS at room temperature for 20 to 30 minutes, with shaking.  
     [0215] The membrane is removed from the wash and placed on a dry piece of 3MM WHATMAN filter paper then wrapped in one layer of plastic wrap, placed on the autoradiography film, and exposed for about five hours depending upon a survey meter indicating the level of radioactivity. The film is developed in an automatic film processor.  
     [0216] Control Hybridization with Normal Oligonucleotides  
     [0217] The purpose of this step is to ensure that the PCR products are transferred efficiently to the nylon membrane.  
     [0218] Following hybridization with the mutant oligonucleotide, as described in the Examples above, each nylon membrane is washed in 2×SSC, 0.1% SDS for 20 minutes at 65° C. to melt off the mutant oligonucleotide probes. The nylon strips are then prehybridized together in 40 ml of TMAC hybridization solution for at least 1 hour at 52° C. in a shaking water bath. 2-5 million counts of each of the normal labeled oligonucleotide probes plus 40 μl of 20 mM stock of unlabeled normal oligonucleotide are added directly to the container containing the nylon membranes and the prehybridization solution. The filter and probes are hybridized at 52° C. with shaking for at least 1 hour. Hybridization can be performed overnight, if necessary. The hybridization solution is poured off, and the nylon membrane is rinsed in 2×SSC, 0. 1% SDS for 1 minute with gentle swirling by hand. The rinse is poured off and the membrane is washed in 2×SSC, 0.1% SDS at room temperature for 20 minutes with shaking.  
     [0219] The nylon membrane is removed placed on a dry piece of 3 MM WHATMAN filter paper. The nylon membrane is then wrapped in one layer of plastic wrap and placed on autoradiography film, and exposure is for at least 1 hour.  
     [0220] For each sample, adequate transfer to the membrane is indicated by a strong autoradiographic hybridization signal. For each sample, an absent or weak signal when hybridized with its normal oligonucleotide, indicates an unsuccessful transfer of PCR product, and it is a false negative. The ASO analysis must be repeated for any sample that did not successfully transfer to the nylon membrane.  
     [0221] Interpreting Results  
     [0222] After hybridizing with mutant oligonucleotides, the results for each exon are interpreted as follows:  
                       TABLE 4A                       Result   Interpretation   Action                                                                                                                                                                                        All quality controls indicate assay is successful   Record results, dark circles are mutation positive, and all others are negative               (+   (−)   NT   NT   NT   Assay not specific,   Rewash                           mutant oligonucleotide   membrane 30                           hybridizing to normal   minutes longer                           DNA.   at appropriate       (+)   (−)   NT   NT   NT       temperature                           Mutant oligonucleotide   and re-expose.                           probe is either washed   Rehybridize                           off or did not   with remaining                           label well enough,   oligonucleo-                           or PCR product is not   signal, perform                           transferred to   tide labeled                           membrane   If still no                           efficiently.   normal                               oligonucleo-                               tide hyb. as                               per the Exam-                               ples to test                               transfer of PCR                               to membrane.       (+)   (−)   NT   NT   NT                           Positive and negative   Perform                           controls indicate assay   standard clean                           is successful, but PCR   up procedures       (+)   (−)   NT   NT   NT   is contaminated.   for PCR                               contamination.                  
 
     [0223] After hybridization with normal oligonucleotides, interpret the results as follows:  
                                           TABLE 4B                                                  Results indicate transfer   Record results.                               of PCR products to                               membrane is successful.       (+)   (−)   NT   NT   NT                                                                                             Results indicate transfer of patient sample #1 is inefficient. May get false negative from this sample   This sample will have to be transferred to another membrane and the assay repeated               (+)   (−)   #1   NT   NT   NT                  
 
     [0224] The sample #1 should be lighter than the controls. Patient samples containing a mutation are generally heterozygous and will hybridize to both the normal and mutant oligonucleotide probes.  
     [0225] Data on Specific Mutations  
     [0226] The following specific mutations are examples of those which are presumed to be clinically significant for typing current cancer cells or a germ line mutation increasing the susceptibility to a tumor. A few of these mutations were also found by others as stated in TABLE 1 above.  
               TABLE 8                       List of Nonsense Mutations                                    T127A, T127g, G144T, G147T, C153T, C174T, A177T, T184A, T184g, G186T, T191A,       T200A, G204T, T208A, A213T, G216T, A231T, T236A, C251A, A252T, C260A, A267T,       C279T, A282T, A285T, C295A, C295g, C297T, T302A, T307A, T307g, T311A, A312T,       A327T, C339T, G342T, A351T, C360T, G369T, G372T, T379A, A381T, T392A, C399T,       T415A, G417T, T422A, T422G, T434A, T434G, A444T, A447T, G450T, G465T, A474T,       G480T, C495T, C509A, C509G, A510T, A522T, A525T, C534T, G540T, G546T, T559A,       C561T, G564T, C582T, G597T, A606T, A621T, C624T, C633T, C639T, A642T, C656A,       C656G, G660T, T664A, G666T, G681T, A696T, T707A, T707G, C710A, G717T, C723T,       G726T, T730A, T733A, T733g, C735T, C747T, G750T, G762T, T772A, A783T, A786T,       T797A, G798T, G807T, G828T, C837T, T856A, G867T, A870T, G882T, G894T, A897T,       T902A, T902G, C903T, C919A, C919g, T925A, G933T, T941A, C964A, C964g, T967A,       T967g, C969T, G975T, T988A, T988g, T991A, T991g, A999T, A1005T, G1017T, A1020T,       G1026T, T1034A, A1038T, A1044T, C1047T, T1057A, T1057g, C1068T, A1077T, G1081A,       G1082A, G1086T, A1092T, G1095T, T1103A, G1128T, A1131T, A1134T, T1163A, G1164T,       A1167T, A1170T, G1173T, G1177A, G1178A, A1182T, C1185T, A1188T, C1199A, C1201A,       C1201g, G1203T, A1212T, G1221T, G1234A, G1235A, C1257T, A1260T, G1269T, G1273A,       G1274A, A1281T, G1290T, T1297A, T1297g, C1312A, C1312g, G1323T, G1329T, C1333A,       C1333g, A1341T, T1357A, G1371T, G1380T, T1385A, T1385G, C1396A, C1396g, G1398T,       A1401T, T1411A, T1411g, G1431T, T1438A, T1438g, T1445A, A1446T, G1452T, A1455T,       A1467T, C1471A, C1471g, G1476T, G1488T, A1494T, A1506T, T1514A, T1514G, A1518T,       A1521T, T1540A, T1540g, G1554T, G1569T, G1584T, C1590T, C1599T, G1602T, A1620T,       T1624A, T1624g, A1626T, A1632T, A1638T, C1648A, C1648g, G1662T, A1674T, A1677T,       T1687A, C1695T, A1698T, G1707T, C1719T, G1722T, C1731T, G1737T, C1740T, C1749T,       G1779T, A1785T, A1791T, C1806T, G1812T, A1815T, G1833T, C1837A, C1837g, G1842T,       A1845T, G1848T, A1860T, A1866T, G1872T, G1902T, G1908T, T1912A, T1912g, C1927A,       C1927g, A1929T, A1938T, A1941T, A1959T, G1989T, A2004T, T2027A, G2031T, T2035A,       C2037T, T2051A, G2061T, G2064T, A2070T, A2073T, A2076T, A2079T, C2084A, C2084G,       C2088T, A2109T, C2118T, G2127T, A2133T, G2136T, G2148T, A2154T, A2157T, A2166T,       G2175T, C2178T, A2187T, A2190T, G2214T, A2220T, T2224A, T2224g, A2250T, T2255A,       C2257A, C2257g, G2268T, A2274T, G2277T, A2301T, G2304T, G2307T, A2310T, G2313T,       G2316T, A2319T, G2325T, A2334T, G2352T, A2361T, T2374A, T2374g, G2379T, G2382T,       T2392A, C2394T, G2400T, A2403T, G2412T, C2428A, C2428g, T2450A, T2450G, C2457T,       G2460T, C2470A, T2473A, T2473g, G2478T, A2496T, A2502T, G2508T, A2517T, T2522A,       C2529T, T2534A, G2544T, A2553T, G2556T, T2573A, A2577T, A2586T, G2598T, A2607T,       T2612A, T2612G, T2617A, G2619T, G2625T, G2643T, G2655T, G2661T, G2664T, G2670T,       C2682T, T2687A, T2687G, T2689A, C2691T, A2703T, C2710A, C2710g, A2712T, C2718T,       C2722A, C2722g, C2737A, C2737g, G2745T, G2754T, G2757T, G2760T, T2765A, T2794A,       T2794g, A2796T, A2799T, C2802T, A2811T, G2823T, T2828A, G2829T, C2832T, A2835T,       G2838T, G2841T, C2847T, G2850T, A2853T, G2859T, A2871T, C2880T, C2919T, A2922T,       A2928T, A2946T, T2951A, A2958T, G2961T, T2978A, C2983A, C2983g, C2988T, A2994T,       G3003T, G3009T, A3027T, G3033T, T3040A, T3040g, C3042T, T3053A, T3053G, A3078T,       C3082A, C3082g, A3090T, A3096T, T3101A, A3102T, A3105T, G3117T, G3120T, G3129T,       G3132T, C3139A, C3139g, C3145A, C3145g, G3150T, A3153T, G3156T, G3162T, G3168T,       A3213T, G3216T, A3228T, G3231T, C3241A, C3241g, G3255T, G3276T, G3297T, G3315T,       C3324T, G3330T, A3339T, A3345T, A3354T, T3358A, A3372T, T3376A, T3376g, T3385A,       C3387T, G3393T, T3401A, T3401G, A3402T, C3405T, G3417T, T3428A, A3429T, G3438T,       A3444T, A3447T, C3450T, G3453T, T3458A, T3458G, G3459T, G3462T, C3471T, T3500A,       T3500G, C3508A, C3508g, T3517A, T3517g, G3519T, C3522T, G3531T, C3549T, T3557A,       G3561T, T3580A, T3580g, G3591T, A3597T, G3600T, G3618T, A3630T, G3633T, A3654T,       C3663T, A3666T, G3669T, G3672T, T3712A, C3717T, C3725A, C3725G, C3726T, A3729T,       A3738T, A3741T, T3745A, T3745g, G3747T, C3754A, C3754g, G3756T, G3759T, T3766A,       T3766g, G3774T, G3780T, G3783T, C3794A, C3798T, T3805A, T3808A, T3808g, A3816T,       C3837T, G3867T, T3872A, A3879T, G3888T, G3891T, T3898A, T3898g, T3901A, T3901g,       C3904A, C3904g, T3907A, A3909T, T3919A, T3919g, C3929A, C3936T, T3946A, A3951T,       C3960T, G3963T, G3978T, G3981T, A3987T, T3992A, T4003A, C4012A, C4012g, C4014T,       C4019A, G4023T, T4027A, G4029T, T4036A, C4056T, T4069A, A4083T, C4086T, C4098T,       G4104T, C4110T, G4113T, A4131T, G4134T, T4138A, C4144A, C4144g, G4152T, G4155T,       A4158T, G4161T, T4171A, G4173T, G4176T, C4185T, G4188T, G4191T, C4194T, C4207A,       C4207g, T4213A, T4213g, G4218T, T4235A, G4236T, G4242T, G4257T, C4265A, C4267A,       C4267g, C4281T, T4294A, T4294g, C4302T, C4305T, C4320T, A4335T, C4341T, C4344T,       G4347T, G4356T, G4362T, T4372A, T4372g, G4374T, C4377T, C4389T, C4406A, C4406G,       G4437T, C4446T, G4455T, C4458T, C4468A, C4468g, G4470T, A4473T, T4483A, T4483g,       C4489A, C4489g, C4491T, A4494T, G4503T, C4508A, C4508G, C4518T, G4527T, A4545T,       G4551T, A4578T, A4584T, G4587T, G4593T, G4599T, C4606A, C4606g, A4617T, C4622A,       C4627A, C4627g, T4630A, T4630g, G4642A, G4643A, C4646A, C4646G, C4658A, C4671T,       A4677T, C4685A, C4685G, C4692T, G4695T, G4698T, A4707T, G4722T, G4725T, C4728T,       C4731T, G4737T, G4740T, T4759A, G4764T, C4775A, C4775G, T4777A, C4785T, G4794T,       G4797T, C4808A, C4808G, G4812T, G4818T, G4845T, G4860T, A4866T, G4875T, C4879A,       C4879g, C4906A, C4906g, T4918A, A4920T, C4929T, T4933A, A4935T, G4944T, C4953T,       T4994A, T4994G, G5004T, G5007T, G5022T, A5025T, G5031T, T5035A, C5044A, C5044g,       G5049T, A5061T, A5064T, G5097T, G5100T, C5117A, C5117G, A5118T, A5127T, A5130T,       T5146A, T5146g, G5163T, G5166T, A5187T, G5199T, T5210A, G5211T, A5223T, T5228A,       T5228G, G5235T, G5244T, G5247T, A5250T, G5254A, G5255A, T5267A, T5267G, G5272A,       G5273A, C5280T, A5289T, G5292T, A5295T, A5298T, G5310T, G5322T, A5328T, G5331T,       G5346T, A5349T, C5358T, A5367T, C5370T, A5376T, G5379T, C5385T, A5391T, A5394T,       G5412T, T5420A, C5423A, T5426A, T5426G, C5454T, G5460T, G5464A, G5465A, C5472T,       T5480A, A5496T, G5499T, C5506A, C5506g, C5509A, C5509g, C5550T, G5563A, G5564A,       G5568T, C5595T, T5603A, G5604T, C5622T, G5625T, G5629A, G5630A, T5635A, C5654A,       C5654G, C5655T, C5660A, C5661T, G5664T, C5678A, C5678G, C5688T, C5708A, C5708G,       G5710A.                  
 
     [0227]               TABLE 9                       List of One Base deletions                                    124delA, 125delT, 126delT, 127delT, 128delA, 129delT, 130delC, 131delT, 132delG, 133delC,       134delT, 135delC, 136delT, 137delT, 138delC, 139delG, 140delC, 141delG, 142delT, 143delT,       144delG, 145delA, 146delA, 147delG, 148delA, 149delA, 150delG, 151delT, 152delA, 153delC,       154delA, 155delA, 156delA, 157delA, 158delT, 159delG, 160delT, 161delC, 162delA, 163delT,       164delT, 165delA, 166delA, 167delT, 168delG, 169delC, 170delT, 171delA, 172delT, 173delG,       174delC, 175delA, 176delG, 177delA, 178delA, 179delA, 180delA, 181delT, 182delC, 183delT,       184delT, 185delA, 186delG, 187delA, 188delG, 189delT, 190delG, 191delT, 192delC, 193delC,       194delC, 195delA, 196delT, 197delC, 198delT, 199delG, 200delT, 201delC, 202delT, 203delG,       204delG, 205delA, 206delG, 207delT, 208delT, 209delG, 210delA, 211delT, 212delC, 213delA,       214delA, 215delG, 216delG, 217delA, 218delA, 219delC, 220delC, 221delT, 222delG, 223delT,       224delC, 225delT, 226delC, 227delC, 228delA, 229delC, 230delA, 231delA, 232delA, 233delG,       234delT, 235delG, 236delT, 237delG, 238delA, 239delC, 240delC, 241delA, 242delC, 243delA,       244delT, 245delA, 246delT, 247delT, 248delT, 249delT, 250delG, 251delC, 252delA, 253delA,       254delA, 255delT, 256delT, 257delT, 258delT, 259delG, 260delC, 261delA, 262delT, 263delG,       264delC, 265delT, 266delG, 267delA, 268delA, 269delA, 270delC, 271delT, 272delT, 273delC,       274delT, 275delC, 276delA, 277delA, 278delC, 279delC, 280delA, 281delG, 282delA, 283delA,       284delG, 285delA, 286delA, 287delA, 288delG, 289delG, 290delG, 291delC, 292delC, 293delT,       294delT, 295delC, 296delA, 297delC, 298delA, 299delG, 300delT, 301delG, 302delT, 303delC,       304delC, 305delT, 306delT, 307delT, 308delA, 309delT, 310delG, 311delT, 312delA, 313delA,       314delG, 315delA, 316delA, 317delT, 318delG, 319delA, 320delT, 321delA, 322delT, 323delA,       324delA, 325delC, 326delC, 327delA, 328delA, 329delA, 330delA, 331delG, 332delG,       333delA, 334delG, 335delC, 336delC, 337delT, 338delA, 339delC, 340delA, 341delA, 342delG,       343delA, 344delA, 345delA, 346delG, 347delT, 348delA, 349delC, 350delG, 351delA, 352delG,       353delA, 354delT, 355delT, 356delT, 357delA, 358delG, 359delT, 360delC, 361delA, 362delA,       363delC, 364delT, 365delT, 366delG, 367delT, 368delT, 369delG, 370delA, 371delA, 372delG,       373delA, 374delG, 375delC, 376delT, 377delA, 378delT, 379delT, 380delG, 381delA, 382delA,       383delA, 384delA, 385delT, 386delC, 387delA, 388delT, 389delT, 390delT, 391delG, 392delT,       393delG, 394delC, 395delT, 396delT, 397delT, 398delT, 399delC, 400delA, 401delG, 402delC,       403delT, 404delT, 405delG, 406delA, 407delC, 408delA, 409delC, 410delA, 411delG, 412delG,       413delT, 414delT, 415delT, 416delG, 417delG, 418delA, 419delG, 420delT, 421delA, 422delT,       423delG, 424delC, 425delA, 426delA, 427delA, 428delC, 429delA, 430delG, 431delC, 432delT,       433delA, 434delT, 435delA, 436delA, 437delT, 438delT, 439delT, 440delT, 441delG, 442delC,       443delA, 444delA, 445delA, 446delA, 447delA, 448delA, 449delG, 450delG, 451delA,       452delA, 453delA, 454delA, 455delT, 456delA, 457delA, 458delC, 459delT, 460delC, 461delT,       462delC, 463delC, 464delT, 465delG, 466delA, 467delA, 468delC, 469delA, 470delT, 471delC,       472delT, 473delA, 474delA, 475delA, 476delA, 477delG, 478delA, 479delT, 480delG, 481delA,       482delA, 483delG, 484delT, 485delT, 486delT, 487delC, 488delT, 489delA, 490delT, 491delC,       492delA, 493delT, 494delC, 495delC, 496delA, 497delA, 498delA, 499delG, 500delT, 501delA,       502delT, 503delG, 504delG, 505delG, 506delC, 507delT, 508delA, 509delC, 510delA, 511delG,       512delA, 513delA, 514delA, 515delC, 516delC, 517delG, 518delT, 519delG, 520delC, 521delC,       522delA, 523delA, 524delA, 525delA, 526delG, 527delA, 528delC, 529delT, 530delT, 531delC,       532delT, 533delA, 534delC, 535delA, 536delG, 537delA, 538delG, 539delT, 540delG, 541delA,       542delA, 543delC, 544delC, 545delC, 546delG, 547delA, 548delA, 549delA, 550delA, 551delT,       552delC, 553delC, 554delT, 555delT, 556delC, 557delC, 558delT, 559delT, 560delG, 561delC,       562delA, 563delG, 564delG, 565delA, 566delA, 567delA, 568delC, 569delC, 570delA,       571delG, 572delT, 573delC, 574delT, 575delC, 576delA, 577delG, 578delT, 579delG, 580delT,       581delC, 582delC, 583delA, 584delA, 585delC, 586delT, 587delC, 588delT, 589delC, 590delT,       591delA, 592delA, 593delC, 594delC, 595delT, 596delT, 597delG, 598delG, 599delA, 600delA,       601delC, 602delT, 603delG, 604delT, 605delG, 606delA, 607delG, 608delA, 609delA, 610delC,       611delT, 612delC, 613delT, 614delG, 615delA, 616delG, 617delG, 618delA, 619delC, 620delA,       621delA, 622delA, 623delG, 624delC, 625delA, 626delG, 627delC, 628delG, 629delG,       630delA, 631delT, 632delA, 633delC, 634delA, 635delA, 636delC, 637delC, 638delT, 639delC,       640delA, 641delA, 642delA, 643delA, 644delG, 645delA, 646delC, 647delG, 648delT, 649delC,       650delT, 651delG, 652delT, 653delC, 654delT, 655delA, 656delC, 657delA, 658delT, 659delT,       660delG, 661delA, 662delA, 663delT, 664delT, 665delG, 666delG, 667delG, 668delA, 669delT,       670delC, 671delT, 672delG, 673delA, 674delT, 675delT, 676delC, 677delT, 678delT, 679delC,       680delT, 681delG, 682delA, 683delA, 684delG, 685delA, 686delT, 687delA, 688delC, 689delC,       690delG, 691delT, 692delT, 693delA, 694delA, 695delT, 696delA, 697delA, 698delG, 699delG,       700delC, 701delA, 702delA, 703delC, 704delT, 705delT, 706delA, 707delT, 708delT, 709delG,       710delC, 711delA, 712delG, 713delT, 714delG, 715delT, 716delG, 717delG, 718delG, 719delA,       720delG, 721delA, 722delT, 723delC, 724delA, 725delA, 726delG, 727delA, 728delA, 729delT,       730delT, 731delG, 732delT, 733delT, 734delA, 735delC, 736delA, 737delA, 738delA, 739delT,       740delC, 741delA, 742delC, 743delC, 744delC, 745delC, 746delT, 747delC, 748delA, 749delA,       750delG, 751delG, 752delA, 753delA, 754delC, 755delC, 756delA, 757delG, 758delG,       759delG, 760delA, 761delT, 762delG, 763delA, 764delA, 765delA, 766delT, 767delC, 768delA,       769delG, 770delT, 771delT, 772delT, 773delG, 774delG, 775delA, 776delT, 777delT, 778delC,       779delT, 780delG, 781delC, 782delA, 783delA, 784delA, 785delA, 786delA, 787delA, 788delG,       789delG, 790delC, 791delT, 792delG, 793delC, 794delT, 795delT, 796delG, 797delT, 798delG,       799delA, 800delA, 801delT, 802delT, 803delT, 804delT, 805delC, 806delT, 807delG, 808delA,       809delG, 810delA, 811delC, 812delG, 813delG, 814delA, 815delT, 816delG, 817delT, 818delA,       819delA, 820delC, 821delA, 822delA, 823delA, 824delT, 825delA, 826delC, 827delT, 828delG,       829delA, 830delA, 831delC, 832delA, 833delT, 834delC, 835delA, 836delT, 837delC, 838delA,       839delA, 840delC, 841delC, 842delC, 843delA, 844delG, 845delT, 846delA, 847delA, 848delT,       849delA, 850delA, 851delT, 852delG, 853delA, 854delT, 855delT, 856delT, 857delG, 858delA,       859delA, 860delC, 861delA, 862delC, 863delC, 864delA, 865delC, 866delT, 867delG, 868delA,       869delG, 870delA, 871delA, 872delG, 873delC, 874delG, 875delT, 876delG, 877delC, 878delA,       879delG, 880delC, 881delT, 882delG, 883delA, 884delG, 885delA, 886delG, 887delG, 888delC,       889delA, 890delT, 891delC, 892delC, 893delA, 894delG, 895delA, 896delA, 897delA, 898delA,       899delG, 900delT, 901delA, 902delT, 903delC, 904delA, 905delG, 906delG, 907delG, 908delT,       909delA, 910delG, 911delT, 912delT, 913delC, 914delT, 915delG, 916delT, 917delT, 918delT,       919delC, 920delA, 921delA, 922delA, 923delC, 924delT, 925delT, 926delG, 927delC, 928delA,       929delT, 930delG, 931delT, 932delG, 933delG, 934delA, 935delG, 936delC, 937delC, 938delA,       939delT, 940delG, 941delT, 942delG, 943delG, 944delC, 945delA, 946delC, 947delA, 948delA,       949delA, 950delT, 951delA, 952delC, 953delT, 954delC, 955delA, 956delT, 957delG, 958delC,       959delC, 960delA, 961delG, 962delC, 963delT, 964delC, 965delA, 966delT, 967delT, 968delA,       969delC, 970delA, 971delG, 972delC, 973delA, 974delT, 975delG, 976delA, 977delG, 978delA,       979delA, 980delC, 981delA, 982delG, 983delC, 984delA, 985delG, 986delT, 987delT, 988delT,       989delA, 990delT, 991delT, 992delA, 993delC, 994delT, 995delC, 996delA, 997delC, 998delT,       999delA, 1000delA, 1001delA, 1002delG, 1003delA, 1004delC, 1005delA, 1006delG,       1007delA, 1008delA, 1009delT, 1010delG, 1011delA, 1012delA, 1013delT, 1014delG,       1015delT, 1016delA, 1017delG, 1018delA, 1019delA, 1020delA, 1021delA, 1022delG,       1023delG, 1024delC, 1025delT, 1026delG, 1027delA, 1028delA, 1029delT, 1030delT,       1031delC, 1032delT, 1033delG, 1034delT, 1035delA, 1036delA, 1037delT, 1038delA,       1039delA, 1040delA, 1041delA, 1042delG, 1043delC, 1044delA, 1045delA, 1046delA,       1047delC, 1048delA, 1049delG, 1050delC, 1051delC, 1052delT, 1053delG, 1054delG,       1055delC, 1056delT, 1057delT, 1058delA, 1059delG, 1060delC, 1061delA, 1062delA,       1063delG, 1064delG, 1065delA, 1066delG, 1067delC, 1068delC, 1069delA, 1070delA,       1071delC, 1072delA, 1073delT, 1074delA, 1075delA, 1076delC, 1077delA, 1078delG,       1079delA, 1080delT, 1081delG, 1082delG, 1083delG, 1084delC, 1085delT, 1086delG,       1087delG, 1088delA, 1089delA, 1090delG, 1091delT, 1092delA, 1093delA, 1094delG,       1095delG, 1096delA, 1097delA, 1098delA, 1099delC, 1100delA, 1101delT, 1102delG,       1103delT, 1104delA, 1105delA, 1106delT, 1107delG, 1108delA, 1109delT, 1110delA,       1111delG, 1112delG, 1113delC, 1114delG, 1115delG, 1116delA, 1117delC, 1118delT,       1119delC, 1120delC, 1121delC, 1122delA, 1123delG, 1124delC, 1125delA, 1126delC,       1127delA, 1128delG, 1129delA, 1130delA, 1131delA, 1132delA, 1133delA, 1134delA,       1135delA, 1136delG, 1137delG, 1138delT, 1139delA, 1140delG, 1141delA, 1142delT,       1143delC, 1144delT, 1145delG, 1146delA, 1147delA, 1148delT, 1149delG, 1150delC,       1151delT, 1152delG, 1153delA, 1154delT, 1155delC, 1156delC, 1157delC, 1158delC,       1159delT, 1160delG, 1161delT, 1162delG, 1163delT, 1164delG, 1165delA, 1166delG,       1167delA, 1168delG, 1169delA, 1170delA, 1171delA, 1172delA, 1173delG, 1174delA,       1175delA, 1176delT, 1177delG, 1178delG, 1179delA, 1180delA, 1181delT, 1182delA,       1183delA, 1184delG, 1185delC, 1186delA, 1187delG, 1188delA, 1189delA, 1190delA,       1191delC, 1192delT, 1193delG, 1194delC, 1195delC, 1196delA, 1197delT, 1198delG,       1199delC, 1200delT, 1201delC, 1202delA, 1203delG, 1204delA, 1205delG, 1206delA,       1207delA, 1208delT, 1209delC, 1210delC, 1211delT, 1212delA, 1213delG, 1214delA,       1215delG, 1216delA, 1217delT, 1218delA, 1219delC, 1220delT, 1221delG, 1222delA,       1223delA, 1224delG, 1225delA, 1226delT, 1227delG, 1228delT, 1229delT, 1230delC,       1231delC, 1232delT, 1233delT, 1234delG, 1235delG, 1236delA, 1237delT, 1238delA,       1239delA, 1240delC, 1241delA, 1242delC, 1243delT, 1244delA, 1245delA, 1246delA,       1247delT, 1248delA, 1249delG, 1250delC, 1251delA, 1252delG, 1253delC, 1254delA,       1255delT, 1256delT, 1257delC, 1258delA, 1259delG, 1260delA, 1261delA, 1262delA,       1263delG, 1264delT, 1265delT, 1266delA, 1267delA, 1268delT, 1269delG, 1270delA,       1271delG, 1272delT, 1273delG, 1274delG, 1275delT, 1276delT, 1277delT, 1278delT,       1279delC, 1280delC, 1281delA, 1282delG, 1283delA, 1284delA, 1285delG, 1286delT,       1287delG, 1288delA, 1289delT, 1290delG, 1291delA, 1292delA, 1293delC, 1294delT,       1295delG, 1296delT, 1297delT, 1298delA, 1299delG, 1300delG, 1301delT, 1302delT,       1303delC, 1304delT, 1305delG, 1306delA, 1307delT, 1308delG, 1309delA, 1310delC,       1311delT, 1312delC, 1313delA, 1314delC, 1315delA, 1316delT, 1317delG, 1318delA,       1319delT, 1320delG, 1321delG, 1322delG, 1323delG, 1324delA, 1325delG, 1326delT,       1327delC, 1328delT, 1329delG, 1330delA, 1331delA, 1332delT, 1333delC, 1334delA,       1335delA, 1336delA, 1337delT, 1338delG, 1339delC, 1340delC, 1341delA, 1342delA,       1343delA, 1344delG, 1345delT, 1346delA, 1347delG, 1348delC, 1349delT, 1350delG,       1351delA, 1352delT, 1353delG, 1354delT, 1355delA, 1356delT, 1357delT, 1358delG,       1359delG, 1360delA, 1361delC, 1362delG, 1363delT, 1364delT, 1365delC, 1366delT,       1367delA, 1368delA, 1369delA, 1370delT, 1371delG, 1372delA, 1373delG, 1374delG,       1375delT, 1376delA, 1377delG, 1378delA, 1379delT, 1380delG, 1381delA, 1382delA,       1383delT, 1384delA, 1385delT, 1386delT, 1387delC, 1388delT, 1389delG, 1390delG,       1391delT, 1392delT, 1393delC, 1394delT, 1395delT, 1396delC, 1397delA, 1398delG,       1399delA, 1400delG, 1401delA, 1402delA, 1403delA, 1404delA, 1405delT, 1406delA,       1407delG, 1408delA, 1409delC, 1410delT, 1411delT, 1412delA, 1413delC, 1414delT,       1415delG, 1416delG, 1417delC, 1418delC, 1419delA, 1420delG, 1421delT, 1422delG,       1423delA, 1424delT, 1425delC, 1426delC, 1427delT, 1428delC, 1429delA, 1430delT,       1431delG, 1432delA, 1433delG, 1434delG, 1435delC, 1436delT, 1437delT, 1438delT,       1439delA, 1440delA, 1441delT, 1442delA, 1443delT, 1444delG, 1445delT, 1446delA,       1447delA, 1448delA, 1449delA, 1450delG, 1451delT, 1452delG, 1453delA, 1454delA,       1455delA, 1456delG, 1457delA, 1458delG, 1459delT, 1460delT, 1461delC, 1462delA,       1463delC, 1464delT, 1465delC, 1466delC, 1467delA, 1468delA, 1469delA, 1470delT,       1471delC, 1472delA, 1473delG, 1474delT, 1475delA, 1476delG, 1477delA, 1478delG,       1479delA, 1480delG, 1481delT, 1482delA, 1483delA, 1484delT, 1485delA, 1486delT,       1487delT, 1488delG, 1489delA, 1490delA, 1491delG, 1492delA, 1493delC, 1494delA,       1495delA, 1496delA, 1497delA, 1498delT, 1499delA, 1500delT, 1501delT, 1502delT,       1503delG, 1504delG, 1505delG, 1506delA, 1507delA, 1508delA, 1509delA, 1510delC,       1511delC, 1512delT, 1513delA, 1514delT, 1515delC, 1516delG, 1517delG, 1518delA,       1519delA, 1520delG, 1521delA, 1522delA, 1523delG, 1524delG, 1525delC, 1526delA,       1527delA, 1528delG, 1529delC, 1530delC, 1531delT, 1532delC, 1533delC, 1534delC,       1535delC, 1536delA, 1537delA, 1538delC, 1539delT, 1540delT, 1541delA, 1542delA,       1543delG, 1544delC, 1545delC, 1546delA, 1547delT, 1548delG, 1549delT, 1550delA,       1551delA, 1552delC, 1553delT, 1554delG, 1555delA, 1556delA, 1557delA, 1558delA,       1559delT, 1560delC, 1561delT, 1562delA, 1563delA, 1564delT, 1565delT, 1566delA,       1567delT, 1568delA, 1569delG, 1570delG, 1571delA, 1572delG, 1573delC, 1574delA,       1575delT, 1576delT, 1577delT, 1578delG, 1579delT, 1580delT, 1581delA, 1582delC, 1583delT,       1584delG, 1585delA, 1586delG, 1587delC, 1588delC, 1589delA, 1590delC, 1591delA,       1592delG, 1593delA, 1594delT, 1595delA, 1596delA, 1597delT, 1598delA, 1599delC,       1600delA, 1601delA, 1602delG, 1603delA, 1604delG, 1605delC, 1606delG, 1607delT,       1608delC, 1609delC, 1610delC, 1611delC, 1612delT, 1613delC, 1614delA, 1615delC,       1616delA, 1617delA, 1618delA, 1619delT, 1620delA, 1621delA, 1622delA, 1623delT,       1624delT, 1625delA, 1626delA, 1627delA, 1628delG, 1629delC, 1630delG, 1631delT,       1632delA, 1633delA, 1634delA, 1635delA, 1636delG, 1637delG, 1638delA, 1639delG,       1640delA, 1641delC, 1642delC, 1643delT, 1644delA, 1645delC, 1646delA, 1647delT,       1648delC, 1649delA, 1650delG, 1651delG, 1652delC, 1653delC, 1654delT, 1655delT,       1656delC, 1657delA, 1658delT, 1659delC, 1660delC, 1661delT, 1662delG, 1663delA,       1664delG, 1665delG, 1666delA, 1667delT, 1668delT, 1669delT, 1670delT, 1671delA,       1672delT, 1673delC, 1674delA, 1675delA, 1676delG, 1677delA, 1678delA, 1679delA,       1680delG, 1681delC, 1682delA, 1683delG, 1684delA, 1685delT, 1686delT, 1687delT,       1688delG, 1689delG, 1690delC, 1691delA, 1692delG, 1693delT, 1694delT, 1695delC,       1696delA, 1697delA, 1698delA, 1699delA, 1700delG, 1701delA, 1702delC, 1703delT,       1704delC, 1705delC, 1706delT, 1707delG, 1708delA, 1709delA, 1710delA, 1711delT,       1712delG, 1713delA, 1714delT, 1715delA, 1716delA, 1717delA, 1718delT, 1719delC,       1720delA, 1721delG, 1722delG, 1723delG, 1724delA, 1725delA, 1726delC, 1727delT,       1728delA, 1729delA, 1730delC, 1731delC, 1732delA, 1733delA, 1734delA, 1735delC,       1736delG, 1737delG, 1738delA, 1739delG, 1740delC, 1741delA, 1742delG, 1743delA,       1744delA, 1745delT, 1746delG, 1747delG, 1748delT, 1749delC, 1750delA, 1751delA,       1752delG, 1753delT, 1754delG, 1755delA, 1756delT, 1757delG, 1758delA, 1759delA,       1760delT, 1761delA, 1762delT, 1763delT, 1764delA, 1765delC, 1766delT, 1767delA,       1768delA, 1769delT, 1770delA, 1771delG, 1772delT, 1773delG, 1774delG, 1775delT,       1776delC, 1777delA, 1778delT, 1779delG, 1780delA, 1781delG, 1782delA, 1783delA,       1784delT, 1785delA, 1786delA, 1787delA, 1788delA, 1789delC, 1790delA, 1791delA,       1792delA, 1793delA, 1794delG, 1795delG, 1796delT, 1797delG, 1798delA, 1799delT,       1800delT, 1801delC, 1802delT, 1803delA, 1804delT, 1805delT, 1806delC, 1807delA,       1808delG, 1809delA, 1810delA, 1811delT, 1812delG, 1813delA, 1814delG, 1815delA,       1816delA, 1817delA, 1818delA, 1819delA, 1820delT, 1821delC, 1822delC, 1823delT,       1824delA, 1825delA, 1826delC, 1827delC, 1828delC, 1829delA, 1830delA, 1831delT,       1832delA, 1833delG, 1834delA, 1835delA, 1836delT, 1837delC, 1838delA, 1839delC,       1840delT, 1841delC, 1842delG, 1843delA, 1844delA, 1845delA, 1846delA, 1847delA,       1848delG, 1849delA, 1850delA, 1851delT, 1852delC, 1853delT, 1854delG, 1855delC,       1856delT, 1857delT, 1858delT, 1859delC, 1860delA, 1861delA, 1862delA, 1863delA,       1864delC, 1865delG, 1866delA, 1867delA, 1868delA, 1869delG, 1870delC, 1871delT,       1872delG, 1873delA, 1874delA, 1875delC, 1876delC, 1877delT, 1878delA, 1879delT,       1880delA, 1881delA, 1882delG, 1883delC, 1884delA, 1885delG, 1886delC, 1887delA,       1888delG, 1889delT, 1890delA, 1891delT, 1892delA, 1893delA, 1894delG, 1895delC,       1896delA, 1897delA, 1898delT, 1899delA, 1900delT, 1901delG, 1902delG, 1903delA,       1904delA, 1905delC, 1906delT, 1907delC, 1908delG, 1909delA, 1910delA, 1911delT,       1912delT, 1913delA, 1914delA, 1915delA, 1916delT, 1917delA, 1918delT, 1919delC,       1920delC, 1921delA, 1922delC, 1923delA, 1924delA, 1925delT, 1926delT, 1927delC,       1928delA, 1929delA, 1930delA, 1931delA, 1932delG, 1933delC, 1934delA, 1935delC,       1936delC, 1937delT, 1938delA, 1939delA, 1940delA, 1941delA, 1942delA, 1943delG,       1944delA, 1945delA, 1946delT, 1947delA, 1948delG, 1949delG, 1950delC, 1951delT,       1952delG, 1953delA, 1954delG, 1955delG, 1956delA, 1957delG, 1958delG, 1959delA,       1960delA, 1961delG, 1962delT, 1963delC, 1964delT, 1965delT, 1966delC, 1967delT,       1968delA, 1969delC, 1970delC, 1971delA, 1972delG, 1973delG, 1974delC, 1975delA,       1976delT, 1977delA, 1978delT, 1979delT, 1980delC, 1981delA, 1982delT, 1983delG,       1984delC, 1985delG, 1986delC, 1987delT, 1988delT, 1989delG, 1990delA, 1991delA,       1992delC, 1993delT, 1994delA, 1995delG, 1996delT, 1997delA, 1998delG, 1999delT,       2000delC, 2001delA, 2002delG, 2003delT, 2004delA, 2005delG, 2006delA, 2007delA,       2008delA, 2009delT, 2010delC, 2011delT, 2012delA, 2013delA, 2014delG, 2015delC,       2016delC, 2017delC, 2018delA, 2019delC, 2020delC, 2021delT, 2022delA, 2023delA,       2024delT, 2025delT, 2026delG, 2027delT, 2028delA, 2029delC, 2030delT, 2031delG,       2032delA, 2033delA, 2034delT, 2035delT, 2036delG, 2037delC, 2038delA, 2039delA,       2040delA, 2041delT, 2042delT, 2043delG, 2044delA, 2045delT, 2046delA, 2047delG,       2048delT, 2049delT, 2050delG, 2051delT, 2052delT, 2053delC, 2054delT, 2055delA,       2056delG, 2057delC, 2058delA, 2059delG, 2060delT, 2061delG, 2062delA, 2063delA,       2064delG, 2065delA, 2066delG, 2067delA, 2068delT, 2069delA, 2070delA, 2071delA,       2072delG, 2073delA, 2074delA, 2075delA, 2076delA, 2077delA, 2078delA, 2079delA,       2080delA, 2081delG, 2082delT, 2083delA, 2084delC, 2085delA, 2086delA, 2087delC,       2088delC, 2089delA, 2090delA, 2091delA, 2092delT, 2093delG, 2094delC, 2095delC,       2096delA, 2097delG, 2098delT, 2099delC, 2100delA, 2101delG, 2102delG, 2103delC,       2104delA, 2105delC, 2106delA, 2107delG, 2108delC, 2109delA, 2110delG, 2111delA,       2112delA, 2113delA, 2114delC, 2115delC, 2116delT, 2117delA, 2118delC, 2119delA,       2120delA, 2121delC, 2122delT, 2123delC, 2124delA, 2125delT, 2126delG, 2127delG,       2128delA, 2129delA, 2130delG, 2131delG, 2132delT, 2133delA, 2134delA, 2135delA,       2136delG, 2137delA, 2138delA, 2139delC, 2140delC, 2141delT, 2142delG, 2143delC,       2144delA, 2145delA, 2146delC, 2147delT, 2148delG, 2149delG, 2150delA, 2151delG,       2152delC, 2153delC, 2154delA, 2155delA, 2156delG, 2157delA, 2158delA, 2159delG,       2160delA, 2161delG, 2162delT, 2163delA, 2164delA, 2165delC, 2166delA, 2167delA,       2168delG, 2169delC, 2170delC, 2171delA, 2172delA, 2173delA, 2174delT, 2175delG,       2176delA, 2177delA, 2178delC, 2179delA, 2180delG, 2181delA, 2182delC, 2183delA,       2184delA, 2185delG, 2186delT, 2187delA, 2188delA, 2189delA, 2190delA, 2191delG,       2192delA, 2193delC, 2194delA, 2195delT, 2196delG, 2197delA, 2198delC, 2199delA,       2200delG, 2201delT, 2202delG, 2203delA, 2204delT, 2205delA, 2206delC, 2207delT,       2208delT, 2209delT, 2210delC, 2211delC, 2212delC, 2213delA, 2214delG, 2215delA,       2216delG, 2217delC, 2218delT, 2219delG, 2220delA, 2221delA, 2222delG, 2223delT,       2224delT, 2225delA, 2226delA, 2227delC, 2228delA, 2229delA, 2230delA, 2231delT,       2232delG, 2233delC, 2234delA, 2235delC, 2236delC, 2237delT, 2238delG, 2239delG,       2240delT, 2241delT, 2242delC, 2243delT, 2244delT, 2245delT, 2246delT, 2247delA, 2248delC,       2249delT, 2250delA, 2251delA, 2252delG, 2253delT, 2254delG, 2255delT, 2256delT,       2257delC, 2258delA, 2259delA, 2260delA, 2261delT, 2262delA, 2263delC, 2264delC,       2265delA, 2266delG, 2267delT, 2268delG, 2269delA, 2270delA, 2271delC, 2272delT,       2273delT, 2274delA, 2275delA, 2276delA, 2277delG, 2278delA, 2279delA, 2280delT,       2281delT, 2282delT, 2283delG, 2284delT, 2285delC, 2286delA, 2287delA, 2288delT,       2289delC, 2290delC, 2291delT, 2292delA, 2293delG, 2294delC, 2295delC, 2296delT,       2297delT, 2298delC, 2299delC, 2300delA, 2301delA, 2302delG, 2303delA, 2304delG,       2305delA, 2306delA, 2307delG, 2308delA, 2309delA, 2310delA, 2311delA, 2312delA,       2313delG, 2314delA, 2315delA, 2316delG, 2317delA, 2318delG, 2319delA, 2320delA,       2321delA, 2322delC, 2323delT, 2324delA, 2325delG, 2326delA, 2327delA, 2328delA,       2329delC, 2330delA, 2331delG, 2332delT, 2333delT, 2334delA, 2335delA, 2336delA,       2337delG, 2338delT, 2339delG, 2340delT, 2341delC, 2342delT, 2343delA, 2344delA,       2345delT, 2346delA, 2347delA, 2348delT, 2349delG, 2350delC, 2351delT, 2352delG,       2353delA, 2354delA, 2355delG, 2356delA, 2357delC, 2358delC, 2359delC, 2360delC,       2361delA, 2362delA, 2363delA, 2364delG, 2365delA, 2366delT, 2367delC, 2368delT,       2369delC, 2370delA, 2371delT, 2372delG, 2373delT, 2374delT, 2375delA, 2376delA,       2377delG, 2378delT, 2379delG, 2380delG, 2381delA, 2382delG, 2383delA, 2384delA,       2385delA, 2386delG, 2387delG, 2388delG, 2389delT, 2390delT, 2391delT, 2392delT,       2393delG, 2394delC, 2395delA, 2396delA, 2397delA, 2398delC, 2399delT, 2400delG,       2401delA, 2402delA, 2403delA, 2404delG, 2405delA, 2406delT, 2407delC, 2408delT,       2409delG, 2410delT, 2411delA, 2412delG, 2413delA, 2414delG, 2415delA, 2416delG,       2417delT, 2418delA, 2419delG, 2420delC, 2421delA, 2422delG, 2423delT, 2424delA,       2425delT, 2426delT, 2427delT, 2428delC, 2429delA, 2430delC, 2431delT, 2432delG,       2433delG, 2434delT, 2435delA, 2436delC, 2437delC, 2438delT, 2439delG, 2440delG,       2441delT, 2442delA, 2443delC, 2444delT, 2445delG, 2446delA, 2447delT, 2448delT,       2449delA, 2450delT, 2451delG, 2452delG, 2453delC, 2454delA, 2455delC, 2456delT,       2457delC, 2458delA, 2459delG, 2460delG, 2461delA, 2462delA, 2463delA, 2464delG,       2465delT, 2466delA, 2467delT, 2468delC, 2469delT, 2470delC, 2471delG, 2472delT,       2473delT, 2474delA, 2475delC, 2476delT, 2477delG, 2478delG, 2479delA, 2480delA,       2481delG, 2482delT, 2483delT, 2484delA, 2485delG, 2486delC, 2487delA, 2488delC,       2489delT, 2490delC, 2491delT, 2492delA, 2493delG, 2494delG, 2495delG, 2496delA,       2497delA, 2498delG, 2499delG, 2500delC, 2501delA, 2502delA, 2503delA, 2504delA,       2505delA, 2506delC, 2507delA, 2508delG, 2509delA, 2510delA, 2511delC, 2512delC,       2513delA, 2514delA, 2515delA, 2516delT, 2517delA, 2518delA, 2519delA, 2520delT,       2521delG, 2522delT, 2523delG, 2524delT, 2525delG, 2526delA, 2527delG, 2528delT,       2529delC, 2530delA, 2531delG, 2532delT, 2533delG, 2534delT, 2535delG, 2536delC,       2537delA, 2538delG, 2539delC, 2540delA, 2541delT, 2542delT, 2543delT, 2544delG,       2545delA, 2546delA, 2547delA, 2548delA, 2549delC, 2550delC, 2551delC, 2552delC,       2553delA, 2554delA, 2555delG, 2556delG, 2557delG, 2558delA, 2559delC, 2560delT,       2561delA, 2562delA, 2563delT, 2564delT, 2565delC, 2566delA, 2567delT, 2568delG,       2569delG, 2570delT, 2571delT, 2572delG, 2573delT, 2574delT, 2575delC, 2576delC,       2577delA, 2578delA, 2579delA, 2580delG, 2581delA, 2582delT, 2583delA, 2584delA,       2585delT, 2586delA, 2587delG, 2588delA, 2589delA, 2590delA, 2591delT, 2592delG,       2593delA, 2594delC, 2595delA, 2596delC, 2597delA, 2598delG, 2599delA, 2600delA,       2601delG, 2602delG, 2603delC, 2604delT, 2605delT, 2606delT, 2607delA, 2608delA,       2609delG, 2610delT, 2611delA, 2612delT, 2613delC, 2614delC, 2615delA, 2616delT,       2617delT, 2618delG, 2619delG, 2620delG, 2621delA, 2622delC, 2623delA, 2624delT,       2625delG, 2626delA, 2627delA, 2628delG, 2629delT, 2630delT, 2631delA, 2632delA,       2633delC, 2634delC, 2635delA, 2636delC, 2637delA, 2638delG, 2639delT, 2640delC,       2641delG, 2642delG, 2643delG, 2644delA, 2645delA, 2646delA, 2647delC, 2648delA,       2649delA, 2650delG, 2651delC, 2652delA, 2653delT, 2654delA, 2655delG, 2656delA,       2657delA, 2658delA, 2659delT, 2660delG, 2661delG, 2662delA, 2663delA, 2664delG,       2665delA, 2666delA, 2667delA, 2668delG, 2669delT, 2670delG, 2671delA, 2672delA,       2673delC, 2674delT, 2675delT, 2676delG, 2677delA, 2678delT, 2679delG, 2680delC,       2681delT, 2682delC, 2683delA, 2684delG, 2685delT, 2686delA, 2687delT, 2688delT,       2689delT, 2690delG, 2691delC, 2692delA, 2693delG, 2694delA, 2695delA, 2696delT,       2697delA, 2698delC, 2699delA, 2700delT, 2701delT, 2702delC, 2703delA, 2704delA,       2705delG, 2706delG, 2707delT, 2708delT, 2709delT, 2710delC, 2711delA, 2712delA,       2713delA, 2714delG, 2715delC, 2716delG, 2717delC, 2718delC, 2719delA, 2720delG,       2721delT, 2722delC, 2723delA, 2724delT, 2725delT, 2726delT, 2727delG, 2728delC,       2729delT, 2730delC, 2731delT, 2732delG, 2733delT, 2734delT, 2735delT, 2736delT, 2737delC,       2738delA, 2739delA, 2740delA, 2741delT, 2742delC, 2743delC, 2744delA, 2745delG,       2746delG, 2747delA, 2748delA, 2749delA, 2750delT, 2751delG, 2752delC, 2753delA,       2754delG, 2755delA, 2756delA, 2757delG, 2758delA, 2759delG, 2760delG, 2761delA,       2762delA, 2763delT, 2764delG, 2765delT, 2766delG, 2767delC, 2768delA, 2769delA,       2770delC, 2771delA, 2772delT, 2773delT, 2774delC, 2775delT, 2776delC, 2777delT,       2778delG, 2779delC, 2780delC, 2781delC, 2782delA, 2783delC, 2784delT, 2785delC,       2786delT, 2787delG, 2788delG, 2789delG, 2790delT, 2791delC, 2792delC, 2793delT,       2794delT, 2795delA, 2796delA, 2797delA, 2798delG, 2799delA, 2800delA, 2801delA,       2802delC, 2803delA, 2804delA, 2805delA, 2806delG, 2807delT, 2808delC, 2809delC,       2810delA, 2811delA, 2812delA, 2813delA, 2814delG, 2815delT, 2816delC, 2817delA,       2818delC, 2819delT, 2820delT, 2821delT, 2822delT, 2823delG, 2824delA, 2825delA,       2826delT, 2827delG, 2828delT, 2829delG, 2830delA, 2831delA, 2832delC, 2833delA,       2834delA, 2835delA, 2836delA, 2837delG, 2838delG, 2839delA, 2840delA, 2841delG,       2842delA, 2843delA, 2844delA, 2845delA, 2846delT, 2847delC, 2848delA, 2849delA,       2850delG, 2851delG, 2852delA, 2853delA, 2854delA, 2855delG, 2856delA, 2857delA,       2858delT, 2859delG, 2860delA, 2861delG, 2862delT, 2863delC, 2864delT, 2865delA,       2866delA, 2867delT, 2868delA, 2869delT, 2870delC, 2871delA, 2872delA, 2873delG,       2874delC, 2875delC, 2876delT, 2877delG, 2878delT, 2879delA, 2880delC, 2881delA,       2882delG, 2883delA, 2884delC, 2885delA, 2886delG, 2887delT, 2888delT, 2889delA,       2890delA, 2891delT, 2892delA, 2893delT, 2894delC, 2895delA, 2896delC, 2897delT,       2898delG, 2899delC, 2900delA, 2901delG, 2902delG, 2903delC, 2904delT, 2905delT,       2906delT, 2907delC, 2908delC, 2909delT, 2910delG, 2911delT, 2912delG, 2913delG,       2914delT, 2915delT, 2916delG, 2917delG, 2918delT, 2919delC, 2920delA, 2921delG,       2922delA, 2923delA, 2924delA, 2925delG, 2926delA, 2927delT, 2928delA, 2929delA,       2930delG, 2931delC, 2932delC, 2933delA, 2934delG, 2935delT, 2936delT, 2937delG,       2938delA, 2939delT, 2940delA, 2941delA, 2942delT, 2943delG, 2944delC, 2945delC,       2946delA, 2947delA, 2948delA, 2949delT, 2950delG, 2951delT, 2952delA, 2953delG,       2954delT, 2955delA, 2956delT, 2957delC, 2958delA, 2959delA, 2960delA, 2961delG,       2962delG, 2963delA, 2964delG, 2965delG, 2966delC, 2967delT, 2968delC, 2969delT,       2970delA, 2971delG, 2972delG, 2973delT, 2974delT, 2975delT, 2976delT, 2977delG,       2978delT, 2979delC, 2980delT, 2981delA, 2982delT, 2983delC, 2984delA, 2985delT,       2986delC, 2987delT, 2988delC, 2989delA, 2990delG, 2991delT, 2992delT, 2993delC,       2994delA, 2995delG, 2996delA, 2997delG, 2998delG, 2999delC, 3000delA, 3001delA,       3002delC, 3003delG, 3004delA, 3005delA, 3006delA, 3007delC, 3008delT, 3009delG,       3010delG, 3011delA, 3012delC, 3013delT, 3014delC, 3015delA, 3016delT, 3017delT,       3018delA, 3019delC, 3020delT, 3021delC, 3022delC, 3023delA, 3024delA, 3025delA,       3026delT, 3027delA, 3028delA, 3029delA, 3030delC, 3031delA, 3032delT, 3033delG,       3034delG, 3035delA, 3036delC, 3037delT, 3038delT, 3039delT, 3040delT, 3041delA,       3042delC, 3043delA, 3044delA, 3045delA, 3046delA, 3047delC, 3048delC, 3049delC,       3050delA, 3051delT, 3052delA, 3053delT, 3054delC, 3055delG, 3056delT, 3057delA,       3058delT, 3059delA, 3060delC, 3061delC, 3062delA, 3063delC, 3064delC, 3065delA,       3066delC, 3067delT, 3068delT, 3069delT, 3070delT, 3071delT, 3072delC, 3073delC, 3074delC,       3075delA, 3076delT, 3077delC, 3078delA, 3079delA, 3080delG, 3081delT, 3082delC,       3083delA, 3084delT, 3085delT, 3086delT, 3087delG, 3088delT, 3089delT, 3090delA,       3091delA, 3092delA, 3093delA, 3094delC, 3095delT, 3096delA, 3097delA, 3098delA,       3099delT, 3100delG, 3101delT, 3102delA, 3103delA, 3104delG, 3105delA, 3106delA,       3107delA, 3108delA, 3109delA, 3110delT, 3111delC, 3112delT, 3113delG, 3114delC,       3115delT, 3116delA, 3117delG, 3118delA, 3119delG, 3120delG, 3121delA, 3122delA,       3123delA, 3124delA, 3125delC, 3126delT, 3127delT, 3128delT, 3129delG, 3030delA,       3131delG, 3132delG, 3133delA, 3134delA, 3135delC, 3136delA, 3137delT, 3138delT,       3139delC, 3140delA, 3141delA, 3142delT, 3143delG, 3144delT, 3145delC, 3146delA,       3147delC, 3148delC, 3149delT, 3150delG, 3151delA, 3152delA, 3153delA, 3154delG,       3155delA, 3156delG, 3157delA, 3158delA, 3159delA, 3160delT, 3161delG, 3162delG,       3163delG, 3164delA, 3165delA, 3166delA, 3167delT, 3168delG, 3169delA, 3170delG,       3171delA, 3172delA, 3173delC, 3174delA, 3175delT, 3176delT, 3177delC, 3178delC,       3179delA, 3180delA, 3181delG, 3182delT, 3183delA, 3184delC, 3185delA, 3186delG,       3187delT, 3188delG, 3189delA, 3190delG, 3191delC, 3192delA, 3193delC, 3194delA,       3195delA, 3196delT, 3197delT, 3198delA, 3199delG, 3200delC, 3201delC, 3202delG,       3203delT, 3204delA, 3205delA, 3206delT, 3207delA, 3208delA, 3209delC, 3210delA,       3211delT, 3212delT, 3213delA, 3214delG, 3215delA, 3216delG, 3217delA, 3218delA,       3219delA, 3220delA, 3221delT, 3222delG, 3223delT, 3224delT, 3225delT, 3226delT,       3227delT, 3228delA, 3229delA, 3230delA, 3231delG, 3232delG, 3233delA, 3234delG,       3235delC, 3236delC, 3237delA, 3238delG, 3239delC, 3240delT, 3241delC, 3242delA,       3243delA, 3244delG, 3245delC, 3246delA, 3247delA, 3248delT, 3249delA, 3250delT,       3251delT, 3252delA, 3253delA, 3254delT, 3255delG, 3256delA, 3257delA, 3258delG,       3259delT, 3260delA, 3261delG, 3262delG, 3263delT, 3264delT, 3265delC, 3266delC,       3267delA, 3268delG, 3269delT, 3270delA, 3271delC, 3272delT, 3273delA, 3274delA,       3275delT, 3276delG, 3277delA, 3278delA, 3279delG, 3280delT, 3281delG, 3282delG,       3283delG, 3284delC, 3285delT, 3286delC, 3287delC, 3288delA, 3289delG, 3290delT,       3291delA, 3292delT, 3293delT, 3294delA, 3295delA, 3296delT, 3297delG, 3298delA,       3299delA, 3300delA, 3301delT, 3302delA, 3303delG, 3304delG, 3305delT, 3306delT,       3307delC, 3308delC, 3309delA, 3310delG, 3311delT, 3312delG, 3313delA, 3314delT,       3315delG, 3316delA, 3317delA, 3318delA, 3319delA, 3320delC, 3321delA, 3322delT,       3323delT, 3324delC, 3325delA, 3326delA, 3327delG, 3328delC, 3329delA, 3330delG,       3331delA, 3332delA, 3333delC, 3334delT, 3335delA, 3336delG, 3337delG, 3338delT,       3339delA, 3340delG, 3341delA, 3342delA, 3343delA, 3344delC, 3345delA, 3346delG,       3347delA, 3348delG, 3349delG, 3350delG, 3351delC, 3352delC, 3353delA, 3354delA,       3355delA, 3356delA, 3357delT, 3358delT, 3359delG, 3360delA, 3361delA, 3362delT,       3363delG, 3364delC, 3365delT, 3366delA, 3367delT, 3368delG, 3369delC, 3370delT,       3371delT, 3372delA, 3373delG, 3374delA, 3375delT, 3376delT, 3377delA, 3378delG,       3379delG, 3380delG, 3381delG, 3382delT, 3383delT, 3384delT, 3385delT, 3386delG,       3387delC, 3388delA, 3389delA, 3390delC, 3391delC, 3392delT, 3393delG, 3394delA,       3395delG, 3396delG, 3397delT, 3398delC, 3399delT, 3400delA, 3401delT, 3402delA,       3403delA, 3404delA, 3405delC, 3406delA, 3407delA, 3408delA, 3409delG, 3410delT,       3411delC, 3412delT, 3413delT, 3414delC, 3415delC, 3416delT, 3417delG, 3418delG,       3419delA, 3420delA, 3421delG, 3422delT, 3423delA, 3424delA, 3425delT, 3426delT,       3427delG, 3428delT, 3429delA, 3430delA, 3431delG, 3432delC, 3433delA, 3434delT,       3435delC, 3436delC, 3437delT, 3438delG, 3439delA, 3440delA, 3441delA, 3442delT,       3443delA, 3444delA, 3445delA, 3446delA, 3447delA, 3448delA, 3449delG, 3450delC,       3451delA, 3452delA, 3453delG, 3454delA, 3455delA, 3456delT, 3457delA, 3458delT,       3459delG, 3460delA, 3461delA, 3462delG, 3463delA, 3464delA, 3465delG, 3466delT,       3467delA, 3468delG, 3469delT, 3470delT, 3471delC, 3472delA, 3473delG, 3474delA,       3475delC, 3476delT, 3477delG, 3478delT, 3479delT, 3480delA, 3481delA, 3482delT,       3483delA, 3484delC, 3485delA, 3486delG, 3487delA, 3488delT, 3489delT, 3490delT,       3491delC, 3492delT, 3493delC, 3494delT, 3495delC, 3496delC, 3497delA, 3498delT,       3499delA, 3500delT, 3501delC, 3502delT, 3503delG, 3504delA, 3505delT, 3506delT,       3507delT, 3508delC, 3509delA, 3510delG, 3511delA, 3512delT, 3513delA, 3514delA,       3515delC, 3516delT, 3517delT, 3518delA, 3519delG, 3520delA, 3521delA, 3522delC,       3523delA, 3524delG, 3525delC, 3526delC, 3527delT, 3528delA, 3529delT, 3530delG,       3531delG, 3532delG, 3533delA, 3534delA, 3535delG, 3536delT, 3537delA, 3538delG,       3539delT, 3540delC, 3541delA, 3542delT, 3543delG, 3544delC, 3545delA, 3546delT,       3547delC, 3548delT, 3549delC, 3550delA, 3551delG, 3552delG, 3553delT, 3554delT,       3555delT, 3556delG, 3557delT, 3558delT, 3559delC, 3560delT, 3561delG, 3562delA,       3563delG, 3564delA, 3565delC, 3566delA, 3567delC, 3568delC, 3569delT, 3570delG,       3571delA, 3572delT, 3573delG, 3574delA, 3575delC, 3576delC, 3577delT, 3578delG,       3579delT, 3580delT, 3581delA, 3582delG, 3583delA, 3584delT, 3585delG, 3586delA,       3587delT, 3588delG, 3589delG, 3590delT, 3591delG, 3592delA, 3593delA, 3594delA,       3595delT, 3596delA, 3597delA, 3598delA, 3599delG, 3600delG, 3601delA, 3602delA,       3603delG, 3604delA, 3605delT, 3606delA, 3607delC, 3608delT, 3609delA, 3610delG,       3611delT, 3612delT, 3613delT, 3614delT, 3615delG, 3616delC, 3617delT, 3618delG,       3619delA, 3620delA, 3621delA, 3622delA, 3623delT, 3624delG, 3625delA, 3626delC,       3627delA, 3628delT, 3629delT, 3630delA, 3631delA, 3632delG, 3633delG, 3634delA,       3635delA, 3636delA, 3637delG, 3638delT, 3639delT, 3640delC, 3641delT, 3642delG,       3643delC, 3644delT, 3645delG, 3646delT, 3647delT, 3648delT, 3649delT, 3650delT, 3651delA,       3652delG, 3653delC, 3654delA, 3655delA, 3656delA, 3657delA, 3658delG, 3659delC,       3660delG, 3661delT, 3662delC, 3663delC, 3664delA, 3665delG, 3666delA, 3667delG,       3668delA, 3669delG, 3670delG, 3671delA, 3672delG, 3673delA, 3674delG, 3675delC       3676delT, 3677delT, 3678delA, 3679delG, 3680delC, 3681delA, 3682delG, 3683delG,       3684delA, 3685delG, 3686delT, 3687delC, 3688delC, 3689delT, 3690delA, 3691delG,       3692delC, 3693delC, 3694delC, 3695delT, 3696delT, 3697delT, 3698delC, 3699delA,       3700delC, 3701delC, 3702delC, 3703delA, 3704delT, 3705delA, 3706delC, 3707delA,       3708delC, 3709delA, 3710delT, 3711delT, 3712delT, 3713delG, 3714delG, 3715delC,       3716delT, 3717delC, 3718delA, 3719delG, 3720delG, 3721delG, 3722delT, 3723delT,       3724delA, 3725delC, 3726delC, 3727delG, 3728delA, 3729delA, 3730delG, 3731delA,       3732delG, 3733delG, 3734delG, 3735delG, 3736delC, 3737delC, 3738delA, 3739delA,       3740delG, 3741delA, 3742delA, 3743delA, 3744delT, 3745delT, 3746delA, 3747delG,       3748delA, 3749delG, 3750delT, 3751delC, 3752delC, 3753delT, 3754delC, 3755delA,       3756delG, 3757delA, 3758delA, 3759delG, 3760delA, 3761delG, 3762delA, 3763delA,       3764delC, 3765delT, 3766delT, 3767delA, 3768delT, 3769delC, 3770delT, 3771delA,       3772delG, 3773delT, 3774delG, 3775delA, 3776delG, 3777delG, 3778delA, 3779delT,       3780delG, 3781delA, 3782delA, 3783delG, 3784delA, 3785delG, 3786delC, 3787delT,       3788delT, 3789delC, 3790delC, 3791delC, 3792delT, 3793delG, 3794delC, 3795delT,       3796delT, 3797delC, 3798delC, 3799delA, 3800delA, 3801delC, 3802delA, 3803delC,       3804delT, 3805delT, 3806delG, 3807delT, 3808delT, 3809delA, 3810delT, 3811delT, 3812delT,       3813delG, 3814delG, 3815delT, 3816delA, 3817delA, 3818delA, 3819delG, 3820delT,       3821delA, 3822delA, 3823delA, 3824delC, 3825delA, 3826delA, 3827delT, 3828delA,       3829delT, 3830delA, 3831delC, 3832delC, 3833delT, 3834delT, 3835delC, 3836delT,       3837delC, 3838delA, 3839delG, 3840delT, 3841delC, 3842delT, 3843delA, 3844delC,       3845delT, 3846delA, 3847delG, 3848delG, 3849delC, 3850delA, 3851delT, 3852delA,       3853delG, 3854delC, 3855delA, 3856delC, 3857delC, 3858delG, 3859delT, 3860delT,       3861delG, 3862delC, 3863delT, 3864delA, 3865delC, 3866delC, 3867delG, 3868delA,       3869delG, 3870delT, 3871delG, 3872delT, 3873delC, 3874delT, 3875delG, 3876delT,       3877delC, 3878delT, 3879delA, 3880delA, 3881delG, 3882delA, 3883delA, 3884delC,       3885delA, 3886delC, 3887delA, 3888delG, 3889delA, 3890delG, 3891delG, 3892delA,       3893delG, 3894delA, 3895delA, 3896delT, 3897delT, 3898delT, 3899delA, 3900delT,       3901delT, 3902delA, 3903delT, 3904delC, 3905delA, 3906delT, 3907delT, 3908delG,       3909delA, 3910delA, 3911delG, 3912delA, 3913delA, 3914delT, 3915delA, 3916delG,       3917delC, 3918delT, 3919delT, 3920delA, 3921delA, 3922delA, 3923delT, 3924delG,       3925delA, 3926delC, 3927delT, 3928delG, 3929delC, 3930delA, 3931delG, 3932delT,       3933delA, 3934delA, 3935delC, 3936delC, 3937delA, 3938delG, 3939delG, 3940delT,       3941delA, 3942delA, 3943delT, 3944delA, 3945delT, 3946delT, 3947delG, 3948delG,       3949delC, 3950delA, 3951delA, 3952delA, 3953delG, 3954delG, 3955delC, 3956delA,       3957delT, 3958delC, 3959delT, 3960delC, 3961delA, 3962delG, 3963delG, 3964delA,       3965delA, 3966delC, 3967delA, 3968delT, 3969delC, 3970delA, 3971delC, 3972delC,       3973delT, 3974delT, 3975delA, 3976delG, 3977delT, 3978delG, 3979delA, 3980delG,       3981delG, 3982delA, 3983delA, 3984delA, 3985delC, 3986delA, 3987delA, 3988delA,       3989delA, 3990delT, 3991delG, 3992delT, 3993delT, 3994delC, 3995delT, 3996delG,       3997delC, 3998delT, 3999delA, 4000delG, 4001delC, 4002delT, 4003delT, 4004delG,       4005delT, 4006delT, 4007delT, 4008delT, 4009delC, 4010delT, 4011delT, 4012delC, 4013delA,       4014delC, 4015delA, 4016delG, 4017delT, 4018delG, 4019delC, 4020delA, 4021delG,       4022delT, 4023delG, 4024delA, 4025delA, 4026delT, 4027delT, 4028delG, 4029delG,       4030delA, 4031delA, 4032delG, 4033delA, 4034delC, 4035delT, 4036delT, 4037delG,       4038delA, 4039delC, 4040delT, 4041delG, 4042delC, 4043delA, 4044delA, 4045delA,       4046delT, 4047delA, 4048delC, 4049delA, 4050delA, 4051delA, 4052delC, 4053delA,       4054delC, 4055delC, 4056delC, 4057delA, 4058delG, 4059delG, 4060delA, 4061delT,       4062delC, 4063delC, 4064delT, 4065delT, 4066delT, 4067delC, 4068delT, 4069delT,       4070delG, 4071delA, 4072delT, 4073delT, 4074delG, 4075delG, 4076delT, 4077delT,       4078delC, 4079delT, 4080delT, 4081delC, 4082delC, 4083delA, 4084delA, 4085delA,       4086delC, 4087delA, 4088delA, 4089delA, 4090delT, 4091delG, 4092delA, 4093delG,       4094delG, 4095delC, 4096delA, 4097delT, 4098delC, 4099delA, 4100delG, 4101delT,       4102delC, 4103delT, 4104delG, 4105delA, 4106delA, 4107delA, 4108delG, 4109delC,       4110delC, 4111delA, 4112delG, 4113delG, 4114delG, 4115delA, 4116delG, 4117delT,       4118delT, 4119delG, 4120delG, 4121delT, 4122delC, 4123delT, 4124delG, 4125delA,       4126delG, 4127delT, 4128delG, 4129delA, 4130delC, 4131delA, 4132delA, 4133delG,       4134delG, 4135delA, 4136delA, 4137delT, 4138delT, 4139delG, 4140delG, 4141delT,       4142delT, 4143delT, 4144delC, 4145delA, 4146delG, 4147delA, 4148delT, 4149delG,       4150delA, 4151delT, 4152delG, 4153delA, 4154delA, 4155delG, 4156delA, 4157delA,       4158delA, 4159delG, 4160delA, 4161delG, 4162delG, 4163delA, 4164delA, 4165delC,       4166delG, 4167delG, 4168delG, 4169delC, 4170delT, 4171delT, 4172delG, 4173delG,       4174delA, 4175delA, 4176delG, 4177delA, 4178delA, 4179delA, 4180delA, 4181delT,       4182delA, 4183delA, 4184delT, 4185delC, 4186delA, 4187delA, 4188delG, 4189delA,       4190delA, 4191delG, 4192delA, 4193delG, 4194delC, 4195delA, 4196delA, 4197delA,       4198delG, 4199delC, 4200delA, 4201delT, 4202delG, 4203delG, 4204delA, 4205delT,       4206delT, 4207delC, 4208delA, 4209delA, 4210delA, 4211delC, 4212delT, 4213delT,       4214delA, 4215delG, 4216delG, 4217delT, 4218delG, 4219delA, 4220delA, 4221delG,       4222delC, 4223delA, 4224delG, 4225delC, 4226delA, 4227delT, 4228delC, 4229delT,       4230delG, 4231delG, 4232delG, 4233delT, 4234delG, 4235delT, 4236delG, 4237delA,       4238delG, 4239delA, 4240delG, 4241delT, 4242delG, 4243delA, 4244delA, 4245delA,       4246delC, 4247delA, 4248delA, 4249delG, 4250delC, 4251delG, 4252delT, 4253delC,       4254delT, 4255delC, 4256delT, 4257delG, 4258delA, 4259delA, 4260delG, 4261delA,       4262delC, 4263delT, 4264delG, 4265delC, 4266delT, 4267delC, 4268delA, 4269delG,       4270delG, 4271delG, 4272delC, 4273delT, 4274delA, 4275delT, 4276delC, 4277delC,       4278delT, 4279delC, 4280delT, 4281delC, 4282delA, 4283delG, 4284delA, 4285delG,       4286delT, 4287delG, 4288delA, 4289delC, 4290delA, 4291delT, 4292delT, 4293delT,       4294delT, 4295delA, 4296delA, 4297delC, 4298delC, 4299delA, 4300delC, 4301delT,       4302delC, 4303delA, 4304delG, 4305delC, 4306delA, 4307delG, 4308delA, 4309delG,       4310delG, 4311delG, 4312delA, 4313delT, 4314delA, 4315delC, 4316delC, 4317delA,       4318delT, 4319delG, 4320delC, 4321delA, 4322delA, 4323delC, 4324delA, 4325delT,       4326delA, 4327delA, 4328delC, 4329delC, 4330delT, 4331delG, 4332delA, 4333delT,       4334delA, 4335delA, 4336delA, 4337delG, 4338delC, 4339delT, 4340delC, 4341delC,       4342delA, 4343delG, 4344delC, 4345delA, 4346delG, 4347delG, 4348delA, 4349delA,       4350delA, 4351delT, 4352delG, 4353delG, 4354delC, 4355delT, 4356delG, 4357delA,       4358delA, 4359delC, 4360delT, 4361delA, 4362delG, 4363delA, 4364delA, 4365delG,       4366delC, 4367delT, 4368delG, 4369delT, 4370delG, 4371delT, 4372delT, 4373delA,       4374delG, 4375delA, 4376delA, 4377delC, 4378delA, 4379delG, 4380delC, 4381delA,       4382delT, 4383delG, 4384delG, 4385delG, 4386delA, 4387delG, 4388delC, 4389delC,       4390delA, 4391delG, 4392delC, 4393delC, 4394delT, 4395delT, 4396delC, 4397delT,       4398delA, 4399delA, 4400delC, 4401delA, 4402delG, 4403delC, 4404delT, 4405delA,       4406delC, 4407delC, 4408delC, 4409delT, 4410delT, 4411delC, 4412delC, 4413delA,       4414delT, 4415delC, 4416delA, 4417delT, 4418delA, 4419delA, 4420delG, 4421delT,       4422delG, 4423delA, 4424delC, 4425delT, 4426delC, 4427delC, 4428delT, 4429delC,       4430delT, 4431delG, 4432delC, 4433delC, 4434delC, 4435delT, 4436delT, 4437delG,       4438delA, 4439delG, 4440delG, 4441delA, 4442delC, 4443delC, 4444delT, 4445delG,       4446delC, 4447delG, 4448delA, 4449delA, 4450delA, 4451delT, 4452delC, 4453delC,       4454delA, 4455delG, 4456delA, 4457delA, 4458delC, 4459delA, 4460delA, 4461delA,       4462delG, 4463delC, 4464delA, 4465delC, 4466delA, 4467delT, 4468delC, 4469delA,       4470delG, 4471delA, 4472delA, 4473delA, 4474delA, 4475delA, 4476delG, 4477delC,       4478delA, 4479delG, 4480delT, 4481delA, 4482delT, 4483delT, 4484delA, 4485delA,       4486delC, 4487delT, 4488delT, 4489delC, 4490delA, 4491delC, 4492delA, 4493delG,       4494delA, 4495delA, 4496delA, 4497delA, 4498delG, 4499delT, 4500delA, 4501delG,       4502delT, 4503delG, 4504delA, 4505delA, 4506delT, 4507delA, 4508delC, 4509delC,       4510delC, 4511delT, 4512delA, 4513delT, 4514delA, 4515delA, 4516delG, 4517delC,       4518delC, 4519delA, 4520delG, 4521delA, 4522delA, 4523delT, 4524delC, 4525delC,       4526delA, 4527delG, 4528delA, 4529delA, 4530delG, 4531delG, 4532delC, 4533delC,       4534delT, 4535delT, 4536delT, 4537delC, 4538delT, 4539delG, 4540delC, 4541delT,       4542delG, 4543delA, 4544delC, 4545delA, 4546delA, 4547delG, 4548delT, 4549delT,       4550delT, 4551delG, 4552delA, 4553delG, 4554delG, 4555delT, 4556delG, 4557delT,       4558delC, 4559delT, 4560delG, 4561delC, 4562delA, 4563delG, 4564delA, 4565delT,       4566delA, 4567delG, 4568delT, 4569delT, 4570delC, 4571delT, 4572delA, 4573delC,       4574delC, 4575delA, 4576delG, 4577delT, 4578delA, 4579delA, 4580delA, 4581delA,       4582delA, 4583delT, 4584delA, 4585delA, 4586delA, 4587delG, 4588delA, 4589delA,       4590delC, 4591delC, 4592delA, 4593delG, 4594delG, 4595delA, 4596delG, 4597delT,       4598delG, 4599delG, 4600delA, 4601delA, 4602delA, 4603delG, 4604delG, 4605delT,       4606delC, 4607delA, 4608delT, 4609delC, 4610delC, 4611delC, 4612delC, 4613delT,       4614delT, 4615delC, 4616delT, 4617delA, 4618delA, 4619delA, 4620delT, 4621delG,       4622delC, 4623delC, 4624delC, 4625delA, 4626delT, 4627delC, 4628delA, 4629delT,       4630delT, 4631delA, 4632delG, 4633delA, 4634delT, 4635delG, 4636delA, 4637delT,       4638delA, 4639delG, 4640delG, 4641delT, 4642delG, 4643delG, 4644delT, 4645delA,       4646delC, 4647delA, 4648delT, 4649delG, 4650delC, 4651delA, 4652delC, 4653delA,       4654delG, 4655delT, 4656delT, 4657delG, 4658delC, 4659delT, 4660delC, 4661delT,       4662delG, 4663delG, 4664delG, 4665delA, 4666delG, 4667delT, 4668delC, 4669delT,       4670delT, 4671delC, 4672delA, 4673delG, 4674delA, 4675delA, 4676delT, 4677delA,       4678delG, 4679delA, 4680delA, 4681delA, 4682delC, 4683delT, 4684delA, 4685delC,       4686delC, 4687delC, 4688delA, 4689delT, 4690delC, 4691delT, 4692delC, 4693delA,       4694delA, 4695delG, 4696delA, 4697delG, 4698delG, 4699delA, 4700delG, 4701delC,       4702delT, 4703delC, 4704delA, 4705delT, 4706delT, 4707delA, 4708delA, 4709delG,       4710delG, 4711delT, 4712delT, 4713delG, 4714delT, 4715delT, 4716delG, 4717delA,       4718delT, 4719delG, 4720delT, 4721delG, 4722delG, 4723delA, 4724delG, 4725delG,       4726delA, 4727delG, 4728delC, 4729delA, 4730delA, 4731delC, 4732delA, 4733delG,       4734delC, 4735delT, 4736delG, 4737delG, 4738delA, 4739delA, 4740delG, 4741delA,       4742delG, 4743delT, 4744delC, 4745delT, 4746delG, 4747delG, 4748delG, 4749delC,       4750delC, 4751delA, 4752delC, 4753delA, 4754delC, 4755delG, 4756delA, 4757delT,       4758delT, 4759delT, 4760delG, 4761delA, 4762delC, 4763delG, 4764delG, 4765delA,       4766delA, 4767delA, 4768delC, 4769delA, 4770delT, 4771delC, 4772delT, 4773delT,       4774delA, 4775delC, 4776delT, 4777delT, 4778delG, 4779delC, 4780delC, 4781delA,       4782delA, 4783delG, 4784delG, 4785delC, 4786delA, 4787delA, 4788delG, 4789delA,       4790delT, 4791delC, 4792delT, 4793delA, 4794delG, 4795delA, 4796delG, 4797delG,       4798delG, 4799delA, 4800delA, 4801delC, 4802delC, 4803delC, 4804delC, 4805delT,       4806delT, 4807delA, 4808delC, 4809delC, 4810delT, 4811delG, 4812delG, 4813delA,       4814delA, 4815delT, 4816delC, 4817delT, 4818delG, 4819delG, 4820delA, 4821delA,       4822delT, 4823delC, 4824delA, 4825delG, 4826delC, 4827delC, 4828delT, 4829delC,       4830delT, 4831delT, 4832delC, 4833delT, 4834delC, 4835delT, 4836delG, 4837delA,       4838delT, 4839delG, 4840delA, 4841delC, 4842delC, 4843delC, 4844delT, 4845delG,       4846delA, 4847delA, 4848delT, 4849delC, 4850delT, 4851delG, 4852delA, 4853delT,       4854delC, 4855delC, 4856delT, 4857delT, 4858delC, 4859delT, 4860delG, 4861delA,       4862delA, 4863delG, 4864delA, 4865delC, 4866delA, 4867delG, 4868delA, 4869delG,       4870delC, 4871delC, 4872delC, 4873delC, 4874delA, 4875delG, 4876delA, 4877delG,       4878delT, 4879delC, 4880delA, 4881delG, 4882delC, 4883delT, 4884delC, 4885delG,       4886delT, 4887delG, 4888delT, 4889delT, 4890delG, 4891delG, 4892delC, 4893delA,       4894delA, 4895delC, 4896delA, 4897delT, 4898delA, 4899delC, 4900delC, 4901delA,       4902delT, 4903delC, 4904delT, 4905delT, 4906delC, 4907delA, 4908delA, 4909delC,       4910delC, 4911delT, 4912delC, 4913delT, 4914delG, 4915delC, 4916delA, 4917delT,       4918delT, 4919delG, 4920delA, 4921delA, 4922delA, 4923delG, 4924delT, 4925delT,       4926delC, 4927delC, 4928delC, 4929delC, 4930delA, 4931delA, 4932delT, 4933delT,       4934delG, 4935delA, 4936delA, 4937delA, 4938delG, 4939delT, 4940delT, 4941delG,       4942delC, 4943delA, 4944delG, 4945delA, 4946delA, 4947delT, 4948delC, 4949delT,       4950delG, 4951delC, 4952delC, 4953delC, 4954delA, 4955delG, 4956delG, 4957delG,       4958delT, 4959delC, 4960delC, 4961delA, 4962delG, 4963delC, 4964delT, 4965delG,       4966delC, 4967delT, 4968delG, 4969delC, 4970delT, 4971delC, 4972delA, 4973delT,       4974delA, 4975delC, 4976delT, 4977delA, 4978delC, 4979delT, 4980delG, 4981delA,       4982delT, 4983delA, 4984delC, 4985delT, 4986delG, 4987delC, 4988delT, 4989delG,       4990delG, 4991delG, 4992delT, 4993delA, 4994delT, 4995delA, 4996delA, 4997delT,       4998delG, 4999delC, 5000delA, 5001delA, 5002delT, 5003delG, 5004delG, 5005delA,       5006delA, 5007delG, 5008delA, 5009delA, 5010delA, 5011delG, 5012delT, 5013delG,       5014delT, 5015delG, 5016delA, 5017delG, 5018delC, 5019delA, 5020delG, 5021delG,       5022delG, 5023delA, 5024delG, 5025delA, 5026delA, 5027delG, 5028delC, 5029delC,       5030delA, 5031delG, 5032delA, 5033delA, 5034delT, 5035delT, 5036delG, 5037delA,       5038delC, 5039delA, 5040delG, 5041delC, 5042delT, 5043delT, 5044delC, 5045delA,       5046delA, 5047delC, 5048delA, 5049delG, 5050delA, 5051delA, 5052delA, 5053delG,       5054delG, 5055delG, 5056delT, 5057delC, 5058delA, 5059delA, 5060delC, 5061delA,       5062delA, 5063delA, 5064delA, 5065delG, 5066delA, 5067delA, 5068delT, 5069delG,       5070delT, 5071delC, 5072delC, 5073delA, 5074delT, 5075delG, 5076delG, 5077delT,       5078delG, 5079delG, 5080delT, 5081delG, 5082delT, 5083delC, 5084delT, 5085delG,       5086delG, 5087delC, 5088delC, 5089delT, 5090delG, 5091delA, 5092delC, 5093delC,       5094delC, 5095delC, 5096delA, 5097delG, 5098delA, 5099delA, 5100delG, 5101delA,       5102delA, 5103delT, 5104delT, 5105delT, 5106delA, 5107delT, 5108delG, 5109delC,       5110delT, 5111delC, 5112delG, 5113delT, 5114delG, 5115delT, 5116delA, 5117delC,       5118delA, 5119delA, 5120delG, 5121delT, 5122delT, 5123delT, 5124delG, 5125delC,       5126delC, 5127delA, 5128delG, 5129delA, 5130delA, 5131delA, 5132delA, 5133delC,       5134delA, 5135delC, 5136delC, 5137delA, 5138delC, 5139delA, 5140delT, 5141delC,       5142delA, 5143delC, 5144delT, 5145delT, 5146delT, 5147delA, 5148delA, 5149delC,       5150delT, 5151delA, 5152delA, 5153delT, 5154delC, 5155delT, 5156delA, 5157delA,       5158delT, 5159delT, 5160delA, 5161delC, 5162delT, 5163delG, 5164delA, 5165delA,       5166delG, 5167delA, 5168delG, 5169delA, 5170delC, 5171delT, 5172delA, 5173delC,       5174delT, 5175delC, 5176delA, 5177delT, 5178delG, 5179delT, 5180delT, 5181delG,       5182delT, 5183delT, 5184delA, 5185delT, 5186delG, 5187delA, 5188delA, 5189delA,       5190delA, 5191delC, 5192delA, 5193delG, 5194delA, 5195delT, 5196delG, 5197delC,       5198delT, 5199delG, 5200delA, 5201delG, 5202delT, 5203delT, 5204delT, 5205delG,       5206delT, 5207delG, 5208delT, 5209delG, 5210delT, 5211delG, 5212delA, 5213delA,       5214delC, 5215delG, 5216delG, 5217delA, 5218delC, 5219delA, 5220delC, 5221delT,       5222delG, 5223delA, 5224delA, 5225delA, 5226delT, 5227delA, 5228delT, 5229delT,       5230delT, 5231delT, 5232delC, 5233delT, 5234delA, 5235delG, 5236delG, 5237delA,       5238delA, 5239delT, 5240delT, 5241delG, 5242delC, 5243delG, 5244delG, 5245delG,       5246delA, 5247delG, 5248delG, 5249delA, 5250delA, 5251delA, 5252delA, 5253delT,       5254delG, 5255delG, 5256delG, 5257delT, 5258delA, 5259delG, 5260delT, 5261delT,       5262delA, 5263delG, 5264delC, 5265delT, 5266delA, 5267delT, 5268delT, 5269delT,       5270delC, 5271delT, 5272delG, 5273delG, 5274delG, 5275delT, 5276delG, 5277delA,       5278delC, 5279delC, 5280delC, 5281delA, 5282delG, 5283delT, 5284delC, 5285delT,       5286delA, 5287delT, 5288delT, 5289delA, 5290delA, 5291delA, 5292delG, 5293delA,       5294delA, 5295delA, 5296delG, 5297delA, 5298delA, 5299delA, 5300delA, 5301delA,       5302delT, 5303delG, 5304delC, 5305delT, 5306delG, 5307delA, 5308delA, 5309delT,       5310delG, 5311delA, 5312delG, 5313delC, 5314delA, 5315delT, 5316delG, 5317delA,       5318delT, 5319delT, 5320delT, 5321delT, 5322delG, 5323delA, 5324delA, 5325delG,       5326delT, 5327delC, 5328delA, 5329delG, 5330delA, 5331delG, 5332delG, 5333delA,       5334delG, 5335delA, 5336delT, 5337delG, 5338delT, 5339delG, 5340delG, 5341delT,       5342delC, 5343delA, 5344delA, 5345delT, 5346delG, 5347delG, 5348delA, 5349delA,       5350delG, 5351delA, 5352delA, 5353delA, 5354delC, 5355delC, 5356delA, 5357delC,       5358delC, 5359delA, 5360delA, 5361delG, 5362delG, 5363delT, 5364delC, 5365delC,       5366delA, 5367delA, 5368delA, 5369delG, 5370delC, 5371delG, 5372delA, 5373delG,       5374delC, 5375delA, 5376delA, 5377delG, 5378delA, 5379delG, 5380delA, 5381delA,       5382delT, 5383delC, 5384delC, 5385delC, 5386delA, 5387delG, 5388delG, 5389delA,       5390delC, 5391delA, 5392delG, 5393delA, 5394delA, 5395delA, 5396delG, 5397delA,       5398delT, 5399delC, 5400delT, 5401delT, 5402delC, 5403delA, 5404delG, 5405delG,       5406delG, 5407delG, 5408delG, 5409delC, 5410delT, 5411delA, 5412delG, 5413delA,       5414delA, 5415delA, 5416delT, 5417delC, 5418delT, 5419delG, 5420delT, 5421delT,       5422delG, 5423delC, 5424delT, 5425delA, 5426delT, 5427delG, 5428delG, 5429delG,       5430delC, 5431delC, 5432delC, 5433delT, 5434delT, 5435delC, 5436delA, 5437delC,       5438delC, 5439delA, 5440delA, 5441delC, 5442delA, 5443delT, 5444delG, 5445delC,       5446delC, 5447delC, 5448delA, 5449delC, 5450delA, 5451delG, 5452delA, 5453delT,       5454delC, 5455delA, 5456delA, 5457delC, 5458delT, 5459delG, 5460delG, 5461delA,       5462delA, 5463delT, 5464delG, 5465delG, 5466delA, 5467delT, 5468delG, 5469delG,       5470delT, 5471delA, 5472delC, 5473delA, 5474delG, 5475delC, 5476delT, 5477delG,       5478delT, 5479delG, 5480delT, 5481delG, 5482delG, 5483delT, 5484delG, 5485delC,       5486delT, 5487delT, 5488delC, 5489delT, 5490delG, 5491delT, 5492delG, 5493delG,       5494delT, 5495delG, 5496delA, 5497delA, 5498delG, 5499delG, 5500delA, 5501delG,       5502delC, 5503delT, 5504delT, 5505delT, 5506delC, 5507delA, 5508delT, 5509delC,       5510delA, 5511delT, 5512delT, 5513delC, 5514delA, 5515delC, 5516delC, 5517delC,       5518delT, 5519delT, 5520delG, 5521delG, 5522delC, 5523delA, 5524delC, 5525delA,       5526delG, 5527delG, 5528delT, 5529delG, 5530delT, 5531delC, 5532delC, 5533delA,       5534delC, 5535delC, 5536delC, 5537delA, 5538delA, 5539delT, 5540delT, 5541delG,       5542delT, 5543delG, 5544delG, 5545delT, 5546delT, 5547delG, 5548delT, 5549delG,       5550delC, 5551delA, 5552delG, 5553delC, 5554delC, 5555delA, 5556delG, 5557delA,       5558delT, 5559delG, 5560delC, 5561delC, 5562delT, 5563delG, 5564delG, 5565delA,       5566delC, 5567delA, 5568delG, 5569delA, 5570delG, 5571delG, 5572delA, 5573delC,       5574delA, 5575delA, 5576delT, 5577delG, 5578delG, 5579delC, 5580delT, 5581delT,       5582delC, 5583delC, 5584delA, 5585delT, 5586delG, 5587delC, 5588delA, 5589delA,       5590delT, 5591delT, 5592delG, 5593delG, 5594delG, 5595delC, 5596delA, 5597delG,       5598delA, 5599delT, 5600delG, 5601delT, 5602delG, 5603delT, 5604delG, 5605delA,       5606delG, 5607delG, 5608delC, 5609delA, 5610delC, 5611delC, 5612delT, 5613delG,       5614delT, 5615delG, 5616delG, 5617delT, 5618delG, 5619delA, 5620delC, 5621delC,       5622delC, 5623delG, 5624delA, 5625delG, 5626delA, 5627delG, 5628delT, 5629delG,       5630delG, 5631delG, 5632delT, 5633delG, 5634delT, 5635delT, 5636delG, 5637delG,       5638delA, 5639delC, 5640delA, 5641delG, 5642delT, 5643delG, 5644delT, 5645delA,       5646delG, 5647delC, 5648delA, 5649delC, 5650delT, 5651delC, 5652delT, 5653delA,       5654delC, 5655delC, 5656delA, 5657delG, 5658delT, 5659delG, 5660delC, 5661delC,       5662delA, 5663delG, 5664delG, 5665delA, 5666delG, 5667delC, 5668delT, 5669delG,       5670delG, 5671delA, 5672delC, 5673delA, 5674delC, 5675delC, 5676delT, 5677delA,       5678delC, 5679delC.                    
     [0228]               TABLE 10                       List of Two Base Deletions                                    4delGA, 5delAT, 6delTT, 7delTT, 8delTA, 9delAT, 10delTC, 11delCT, 12delTG, 132delGC,       133delCT, 134delTC, 135delCT, 136delTT, 137delTC, 138delCG, 139delGC, 140delCG,       141delGT, 142delTT, 143delTG, 144delGA, 145delAA, 146delAG, 147delGA, 148delAA,       149delAG, 150delGT, 151delTA, 152delAC, 153delCA, 154delAA, 155delAA, 156delAA,       157delAT, 158delTG, 159delGT, 160delTC, 161delCA, 162delAT, 163delTT, 164delTA,       165delAA, 166delAT, 167delTG, 168delGC, 169delCT, 170delTA, 171delAT, 172delTG,       173delGC, 174delCA, 175delAG, 176delGA, 177delAA, 178delAA, 179delAA, 180delAT,       181delTC, 182delCT, 183delTT, 184delTA, 185delAG, 186delGA, 187delAG, 188delGT,       189delTG, 190delGT, 191delTC, 192delCC, 193delCC, 194delCA, 195delAT, 196delTC,       197delCT, 198delTG, 199delGT, 200delTC, 201delCT, 202delTG, 203delGG, 204delGA,       205delAG, 206delGT, 207delTT, 208delTG, 209delGA, 210delAT, 211delTC, 212delCA,       213delAA, 214delAG, 215delGG, 216delGA, 217delAA, 218delAC, 219delCC, 220delCT,       221delTG, 222delGT, 223delTC, 224delCT, 225delTC, 226delCC, 227delCA, 228delAC,       229delCA, 230delAA, 231delAA, 232delAG, 233delGT, 234delTG, 235delGT, 236delTG,       237delGA, 238delAC, 239delCC, 240delCA, 241delAC, 242delCA, 243delAT, 244delTA,       245delAT, 246delTT, 247delTT, 248delTT, 249delTG, 250delGC, 251delCA, 252delAA,       253delAA, 254delAT, 255delTT, 256delTT, 257delTT, 258delTG, 259delGC, 260delCA,       261delAT, 262delTG, 263delGC, 264delCT, 265delTG, 266delGA, 267delAA, 268delAA,       269delAC, 270delCT, 271delTT, 272delTC, 273delCT, 274delTC, 275delCA, 276delAA,       277delAC, 278delCC, 279delCA, 280delAG, 281delGA, 282delAA, 283delAG, 284delGA,       285delAA, 286delAA, 287delAG, 288delGG, 289delGG, 290delGC, 291delCC, 292delCT,       293delTT, 294delTC, 295delCA, 296delAC, 297delCA, 298delAG, 299delGT, 300delTG,       301delGT, 302delTC, 303delCC, 304delCT, 305delTT, 306delTT, 307delTA, 308delAT,       309delTG, 310delGT, 311delTA, 312delAA, 313delAG, 314delGA, 315delAA, 316delAT,       317delTG, 318delGA, 319delAT, 320delTA, 321delAT, 322delTA, 323delAA, 324delAC,       325delCC, 326delCA, 327delAA, 328delAA, 329delAA, 330delAG, 331delGG, 332delGA,       333delAG, 334delGC, 335delCC, 336delCT, 337delTA, 338delAC, 339delCA, 340delAA,       341delAG, 342delGA, 343delAA, 344delAA, 345delAG, 346delGT, 347delTA, 348delAC,       349delCG, 350delGA, 351delAG, 352delGA, 353delAT, 354delTT, 355delTT, 356delTA,       357delAG, 358delGT, 359delTC, 360delCA, 361delAA, 362delAC, 363delCT, 364delTT,       365delTG, 366delGT, 367delTT, 368delTG, 369delGA, 370delAA, 371delAG, 372delGA,       373delAG, 374delGC, 375delCT, 376delTA, 377delAT, 378delTT, 379delTG, 380delGA,       381delAA, 382delAA, 383delAA, 384delAT, 385delTC, 386delCA, 387delAT, 388delTT,       389delTT, 390delTG, 391delGT, 392delTG, 393delGC, 394delCT, 395delTT, 396delTT,       397delTT, 398delTC, 399delCA, 400delAG, 401delGC, 402delCT, 403delTT, 404delTG,       405delGA, 406delAC, 407delCA, 408delAC, 409delCA, 410delAG, 411delGG, 412delGT,       413delTT, 414delTT, 415delTG, 416delGG, 417delGA, 418delAG, 419delGT, 420delTA,       421delAT, 422delTG, 423delGC, 424delCA, 425delAA, 426delAA, 427delAC, 428delCA,       429delAG, 430delGC, 431delCT, 432delTA, 433delAT, 434delTA, 435delAA, 436delAT,       437delTT, 438delTT, 439delTT, 440delTG, 441delGC, 442delCA, 443delAA, 444delAA,       445delAA, 446delAA, 447delAA, 448delAG, 449delGG, 450delGA, 451delAA, 452delAA,       453delAA, 454delAT, 455delTA, 456delAA, 457delAC, 458delCT, 459delTC, 460delCT,       461delTC, 462delCC, 463delCT, 464delTG, 465delGA, 466delAA, 467delAC, 468delCA,       469delAT, 470delTC, 471delCT, 472delTA, 473delAA, 474delAA, 475delAA, 476delAG,       477delGA, 478delAT, 479delTG, 480delGA, 481delAA, 482delAG, 483delGT, 484delTT,       485delTT, 486delTC, 487delCT, 488delTA, 489delAT, 490delTC, 491delCA, 492delAT,       493delTC, 494delCC, 495delCA, 496delAA, 497delAA, 498delAG, 499delGT, 500delTA,       501delAT, 502delTG, 503delGG, 504delGG, 505delGC, 506delCT, 507delTA, 508delAC,       509delCA, 510delAG, 511delGA, 512delAA, 513delAA, 514delAC, 515delCC, 516delCG,       517delGT, 518delTG, 519delGC, 520delCC, 521delCA, 522delAA, 523delAA, 524delAA,       525delAG, 526delGA, 527delAC, 528delCT, 529delTT, 530delTC, 531delCT, 532delTA,       533delAC, 534delCA, 535delAG, 536delGA, 537delAG, 538delGT, 539delTG, 540delGA,       541delAA, 542delAC, 543delCC, 544delCC, 545delCG, 546delGA, 547delAA, 548delAA,       549delAA, 550delAT, 551delTC, 552delCC, 553delCT, 554delTT, 555delTC, 556delCC,       557delCT, 558delTT, 559delTG, 560delGC, 561delCA, 562delAG, 563delGG, 564delGA,       565delAA, 566delAA, 567delAC, 568delCC, 569delCA, 570delAG, 571delGT, 572delTC,       573delCT, 574delTC, 575delCA, 576delAG, 577delGT, 578delTG, 579delGT, 580delTC,       581delCC, 582delCA, 583delAA, 584delAC, 585delCT, 586delTC, 587delCT, 588delTC,       589delCT, 590delTA, 591delAA, 592delAC, 593delCC, 594delCT, 595delTT, 596delTG,       597delGG, 598delGA, 599delAA, 600delAC, 601delCT, 602delTG, 603delGT, 604delTG,       605delGA, 606delAG, 607delGA, 608delAA, 609delAC, 610delCT, 611delTC, 612delCT,       613delTG, 614delGA, 615delAG, 616delGG, 617delGA, 618delAC, 619delCA, 620delAA,       621delAA, 622delAG, 623delGC, 624delCA, 625delAG, 626delGC, 627delCG, 628delGG,       629delGA, 630delAT, 631delTA, 632delAC, 633delCA, 634delAA, 635delAC, 636delCC,       637delCT, 638delTC, 639delCA, 640delAA, 641delAA, 642delAA, 643delAG, 644delGA,       645delAC, 646delCG, 647delGT, 648delTC, 649delCT, 650delTG, 651delGT, 652delTC,       653delCT, 654delTA, 655delAC, 656delCA, 657delAT, 658delTT, 659delTG, 660delGA,       661delAA, 662delAT, 663delTT, 664delTG, 665delGG, 666delGG, 667delGA, 668delAT,       669delTC, 670delCT, 671delTG, 672delGA, 673delAT, 674delTT, 675delTC, 676delCT,       677delTT, 678delTC, 679delCT, 680delTG, 681delGA, 682delAA, 683delAG, 684delGA,       685delAT, 686delTA, 687delAC, 688delCC, 689delCG, 690delGT, 691delTT, 692delTA,       693delAA, 694delAT, 695delTA, 696delAA, 697delAG, 698delGG, 699delGC, 700delCA,       701delAA, 702delAC, 703delCT, 704delTT, 705delTA, 706delAT, 707delTT, 708delTG,       709delGC, 710delCA, 711delAG, 712delGT, 713delTG, 714delGT, 715delTG, 716delGG,       717delGG, 718delGA, 719delAG, 720delGA, 721delAT, 722delTC, 723delCA, 724delAA,       725delAG, 726delGA, 727delAA, 728delAT, 729delTT, 730delTG, 731delGT, 732delTT,       733delTA, 734delAC, 735delCA, 736delAA, 737delAA, 738delAT, 739delTC, 740delCA,       741delAC, 742delCC, 743delCC, 744delCC, 745delCT, 746delTC, 747delCA, 748delAA,       749delAG, 750delGG, 751delGA, 752delAA, 753delAC, 754delCC, 755delCA, 756delAG,       757delGG, 758delGG, 759delGA, 760delAT, 761delTG, 762delGA, 763delAA, 764delAA,       765delAT, 766delTC, 767delCA, 768delAG, 769delGT, 770delTT, 771delTT, 772delTG,       773delGG, 774delGA, 775delAT, 776delTT, 777delTC, 778delCT, 779delTG, 780delGC,       781delCA, 782delAA, 783delAA, 784delAA, 785delAA, 786delAA, 787delAG, 788delGG,       789delGC, 790delCT, 791delTG, 792delGC, 793delCT, 794delTT, 795delTG, 796delGT,       797delTG, 798delGA, 799delAA, 800delAT, 801delTT, 802delTT, 803delTT, 804delTC,       805delCT, 806delTG, 807delGA, 808delAG, 809delGA, 810delAC, 811delCG, 812delGG,       813delGA, 814delAT, 815delTG, 816delGT, 817delTA, 818delAA, 819delAC, 820delCA,       821delAA, 822delAA, 823delAT, 824delTA, 825delAC, 826delCT, 827delTG, 828delGA,       829delAA, 830delAC, 831delCA, 832delAT, 833delTC, 834delCA, 835delAT, 836delTC,       837delCA, 838delAA, 839delAC, 840delCC, 841delCC, 842delCA, 843delAG, 844delGT,       845delTA, 846delAA, 847delAT, 848delTA, 849delAA, 850delAT, 851delTG, 852delGA,       853delAT, 854delTT, 855delTT, 856delTG, 857delGA, 858delAA, 859delAC, 860delCA,       861delAC, 862delCC, 863delCA, 864delAC, 865delCT, 866delTG, 867delGA, 868delAG,       869delGA, 870delAA, 871delAG, 872delGC, 873delCG, 874delGT, 875delTG, 876delGC,       877delCA, 878delAG, 879delGC, 880delCT, 881delTG, 882delGA, 883delAG, 884delGA,       885delAG, 886delGG, 887delGC, 888delCA, 889delAT, 890delTC, 891delCC, 892delCA,       893delAG, 894delGA, 895delAA, 896delAA, 897delAA, 898delAG, 899delGT, 900delTA,       901delAT, 902delTC, 903delCA, 904delAG, 905delGG, 906delGG, 907delGT, 908delTA,       909delAG, 910delGT, 911delTT, 912delTC, 913delCT, 914delTG, 915delGT, 916delTT,       917delTT, 918delTC, 919delCA, 920delAA, 921delAA, 922delAC, 923delCT, 924delTT,       925delTG, 926delGC, 927delCA, 928delAT, 929delTG, 930delGT, 931delTG, 932delGG,       933delGA, 934delAG, 935delGC, 936delCC, 937delCA, 938delAT, 939delTG, 940delGT,       941delTG, 942delGG, 943delGC, 944delCA, 945delAC, 946delCA, 947delAA, 948delAA,       949delAT, 950delTA, 951delAC, 952delCT, 953delTC, 954delCA, 955delAT, 956delTG,       957delGC, 958delCC, 959delCA, 960delAG, 961delGC, 962delCT, 963delTC, 964delCA,       965delAT, 966delTT, 967delTA, 968delAC, 969delCA, 970delAG, 971delGC, 972delCA,       973delAT, 974delTG, 975delGA, 976delAG, 977delGA, 978delAA, 979delAC, 980delCA,       981delAG, 982delGC, 983delCA, 984delAG, 985delGT, 986delTT, 987delTT, 988delTA,       989delAT, 990delTT, 991delTA, 992delAC, 993delCT, 994delTC, 995delCA, 996delAC,       997delCT, 998delTA, 999delAA, 1000delAA, 1001delAG, 1002delGA, 1003delAC,       1004delCA, 1005delAG, 1006delGA, 1007delAA, 1008delAT, 1009delTG, 1010delGA,       1011delAA, 1012delAT, 1013delTG, 1014delGT, 1015delTA, 1016delAG, 1017delGA,       1018delAA, 1019delAA, 1020delAA, 1021delAG, 1022delGG, 1023delGC, 1024delCT,       1025delTG, 1026delGA, 1027delAA, 1028delAT, 1029delTT, 1030delTC, 1031delCT,       1032delTG, 1033delGT, 1034delTA, 1035delAA, 1036delAT, 1037delTA, 1038delAA,       1039delAA, 1040delAA, 1041delAG, 1042delGC, 1043delCA, 1044delAA, 1045delAA,       1046delAC, 1047delCA, 1048delAG, 1049delGC, 1050delCC, 1051delCT, 1052delTG,       1053delGG, 1054delGC, 1055delCT, 1056delTT, 1057delTA, 1058delAG, 1059delGC,       1060delCA, 1061delAA, 1062delAG, 1063delGG, 1064delGA, 1065delAG, 1066delGC,       1067delCC, 1068delCA, 1069delAA, 1070delAC, 1071delCA, 1072delAT, 1073delTA,       1074delAA, 1075delAC, 1076delCA, 1077delAG, 1078delGA, 1079delAT, 1080delTG,       1081delGG, 1082delGG, 1083delGC, 1084delCT, 1085delTG, 1086delGG, 1087delGA,       1088delAA, 1089delAG, 1090delGT, 1091delTA, 1092delAA, 1093delAG, 1094delGG,       1095delGA, 1096delAA, 1097delAA, 1098delAC, 1099delCA, 1100delAT, 1101delTG,       1102delGT, 1103delTA, 1104delAA, 1105delAT, 1106delTG, 1107delGA, 1108delAT,       1109delTA, 1110delAG, 1111delGG, 1112delGC, 1113delCG, 1114delGG, 1115delGA,       1116delAC, 1117delCT, 1118delTC, 1119delCC, 1120delCC, 1121delCA, 1122delAG,       1123delGC, 1124delCA, 1125delAC, 1126delCA, 1127delAG, 1128delGA, 1129delAA,       1130delAA, 1131delAA, 1132delAA, 1133delAA, 1134delAA, 1135delAG, 1136delGG,       1137delGT, 1138delTA, 1139delAG, 1140delGA, 1141delAT, 1142delTC, 1143delCT,       1144delTG, 1145delGA, 1146delAA, 1147delAT, 1148delTG, 1149delGC, 1150delCT,       1151delTG, 1152delGA, 1153delAT, 1154delTC, 1155delCC, 1156delCC, 1157delCC,       1158delCT, 1159delTG, 1160delGT, 1161delTG, 1162delGT, 1163delTG, 1164delGA,       1165delAG, 1166delGA, 1167delAG, 1168delGA, 1169delAA, 1170delAA, 1171delAA,       1172delAG, 1173delGA, 1174delAA, 1175delAT, 1176delTG, 1177delGG, 1178delGA,       1179delAA, 1180delAT, 1181delTA, 1182delAA, 1183delAG, 1184delGC, 1185delCA,       1186delAG, 1187delGA, 1188delAA, 1189delAA, 1190delAC, 1191delCT, 1192delTG,       1193delGC, 1194delCC, 1195delCA, 1196delAT, 1197delTG, 1198delGC, 1199delCT,       1200delTC, 1201delCA, 1202delAG, 1203delGA, 1204delAG, 1205delGA, 1206delAA,       1207delAT, 1208delTC, 1209delCC, 1210delCT, 1211delTA, 1212delAG, 1213delGA,       1214delAG, 1215delGA, 1216delAT, 1217delTA, 1218delAC, 1219delCT, 1220delTG,       1221delGA, 1222delAA, 1223delAG, 1224delGA, 1225delAT, 1226delTG, 1227delGT,       1228delTT, 1229delTC, 1230delCC, 1331delCT, 1232delTT, 1233delTG, 1234delGG,       1235delGA, 1236delAT, 1237delTA, 1238delAA, 1239delAC, 1240delCA, 1241delAC,       1242delCT, 1243delTA, 1244delAA, 1245delAA, 1246delAT, 1247delTA, 1248delAG,       1249delGC, 1250delCA, 1251delAG, 1252delGC, 1253delCA, 1254delAT, 1255delTT,       1256delTC, 1257delCA, 1258delAG, 1259delGA, 1260delAA, 1261delAA, 1262delAG,       1263delGT, 1264delTT, 1265delTA, 1266delAA, 1267delAT, 1268delTG, 1269delGA,       1270delAG, 1271delGT, 1272delTG, 1273delGG, 1274delGT, 1275delTT, 1276delTT,       1277delTT, 1278delTC, 1279delCC, 1280delCA, 1281delAG, 1282delGA, 1283delAA,       1284delAG, 1285delGT, 1286delTG, 1287delGA, 1288delAT, 1289delTG, 1290delGA,       1291delAA, 1292delAC, 1293delCT, 1294delTG, 1295delGT, 1296delTT, 1297delTA,       1298delAG, 1299delGG, 1300delGT, 1301delTT, 1302delTC, 1303delCT, 1304delTG,       1305delGA, 1306delAT, 1307delTG, 1308delGA, 1309delAC, 1310delCT, 1311delTC,       1312delCA, 1313delAC, 1314delCA, 1315delAT, 1316delTG, 1317delGA, 1318delAT,       1319delTG, 1320delGG, 1321delGG, 1322delGG, 1323delGA, 1324delAG, 1325delGT,       1326delTC, 1327delCT, 1328delTG, 1329delGA, 1330delAA, 1331delAT, 1332delTC,       1333delCA, 1334delAA, 1335delAA, 1336delAT, 1337delTG, 1338delGC, 1339delCC,       1340delCA, 1341delAA, 1342delAA, 1343delAG, 1344delGT, 1345delTA, 1346delAG,       1347delGC, 1348delCT, 1349delTG, 1350delGA, 1351delAT, 1352delTG, 1353delGT,       1354delTA, 1355delAT, 1356delTT, 1357delTG, 1358delGG, 1359delGA, 1360delAC,       1361delCG, 1362delGT, 1363delTT, 1364delTC, 1365delCT, 1366delTA, 1367delAA,       1368delAA, 1369delAT, 1370delTG, 1371delGA, 1372delAG, 1373delGG, 1374delGT,       1375delTA, 1376delAG, 1377delGA, 1378delAT, 1379delTG, 1380delGA, 1381delAA,       1382delAT, 1383delTA, 1384delAT, 1385delTT, 1386delTC, 1387delCT, 1388delTG,       1389delGG, 1390delGT, 1391delTT, 1392delTC, 1393delCT, 1394delTT, 1395delTC,       1396delCA, 1397delAG, 1398delGA, 1399delAG, 1400delGA, 1401delAA, 1402delAA,       1403delAA, 1404delAT, 1405delTA, 1406delAG, 1407delGA, 1408delAC, 1409delCT,       1410delTT, 1411delTA, 1412delAC, 1413delCT, 1414delTG, 1415delGG, 1416delGC,       1417delCC, 1418delCA, 1419delAG, 1420delGT, 1421delTG, 1422delGA, 1423delAT,       1424delTC, 1425delCC, 1426delCT, 1427delTC, 1428delCA, 1429delAT, 1430delTG,       1431delGA, 1432delAG, 1433delGG, 1434delGC, 1435delCT, 1436delTT, 1437delTT,       1438delTA, 1439delAA, 1440delAT, 1441delTA, 1442delAT, 1443delTG, 1444delGT,       1445delTA, 1446delAA, 1447delAA, 1448delAA, 1449delAG, 1450delGT, 1451delTG,       1452delGA, 1453delAA, 1454delAA, 1455delAG, 1456delGA, 1457delAG, 1458delGT,       1459delTT, 1460delTC, 1461delCA, 1462delAC, 1463delCT, 1464delTC, 1465delCC,       1466delCA, 1467delAA, 1468delAA, 1469delAT, 1470delTC, 1471delCA, 1472delAG,       1473delGT, 1474delTA, 1475delAG, 1476delGA, 1477delAG, 1478delGA, 1479delAG,       1480delGT, 1481delTA, 1482delAA, 1483delAT, 1484delTA, 1485delAT, 1486delTT,       1487delTG, 1488delGA, 1489delAA, 1490delAG, 1491delGA, 1492delAC, 1493delCA,       1494delAA, 1495delAA, 1496delAA, 1497delAT, 1498delTA, 1499delAT, 1500delTT,       1501delTT, 1502delTG, 1503delGG, 1504delGG, 1505delGA, 1506delAA, 1507delAA,       1508delAA, 1509delAC, 1510delCC, 1511delCT, 1512delTA, 1513delAT, 1514delTC,       1515delCG, 1516delGG, 1517delGA, 1518delAA, 1519delAG, 1520delGA, 1521delAA,       1522delAG, 1523delGG, 1524delGC, 1525delCA, 1526delAA, 1527delAG, 1528delGC,       1529delCC, 1530delCT, 1531delTC, 1532delCC, 1533delCC, 1534delCC, 1535delCA,       1536delAA, 1537delAC, 1538delCT, 1539delTT, 1540delTA, 1541delAA, 1542delAG,       1543delGC, 1544delCC, 1545delCA, 1546delAT, 1547delTG, 1548delGT, 1549delTA,       1550delAA, 1551delAC, 1552delCT, 1553delTG, 1554delGA, 1555delAA, 1556delAA,       1557delAA, 1558delAT, 1559delTC, 1560delCT, 1561delTA, 1562delAA, 1563delAT,       1564delTT, 1565delTA, 1566delAT, 1567delTA, 1568delAG, 1569delGG, 1570delGA,       1571delAG, 1572delGC, 1573delCA, 1574delAT, 1575delTT, 1576delTT, 1577delTG,       1578delGT, 1579delTT, 1580delTA, 1581delAC, 1582delCT, 1583delTG, 1584delGA,       1585delAG, 1586delGC, 1587delCC, 1588delCA, 1589delAC, 1590delCA, 1591delAG,       1592delGA, 1593delAT, 1594delTA, 1595delAA, 1596delAT, 1597delTA, 1598delAC,       1599delCA, 1600delAA, 1601delAG, 1602delGA, 1603delAG, 1604delGC, 1605delCG,       1606delGT, 1607delTC, 1608delCC, 1609delCC, 1610delCC, 1611delCT, 1612delTC,       1613delCA, 1614delAC, 1615delCA, 1616delAA, 1617delAA, 1618delAT, 1619delTA,       1620delAA, 1621delAA, 1622delAT, 1623delTT, 1624delTA, 1625delAA, 1626delAA,       1627delAG, 1628delGC, 1629delCG, 1630delGT, 1631delTA, 1632delAA, 1633delAA,       1634delAA, 1635delAG, 1636delGG, 1637delGA, 1638delAG, 1639delGA, 1640delAC,       1641delCC, 1642delCT, 1643delTA, 1644delAC, 1645delCA, 1646delAT, 1647delTC,       1648delCA, 1649delAG, 1650delGG, 1651delGC, 1652delCC, 1653delCT, 1654delTT,       1655delTC, 1656delCA, 1657delAT, 1658delTC, 1659delCC, 1660delCT, 1661delTG,       1662delGA, 1663delAG, 1664delGG, 1665delGA, 1666delAT, 1667delTT, 1668delTT,       1669delTT, 1670delTA, 1671delAT, 1672delTC, 1673delCA, 1674delAA, 1675delAG,       1676delGA, 1677delAA, 1678delAA, 1679delAG, 1680delGC, 1681delCA, 1682delAG,       1683delGA, 1684delAT, 1685delTT, 1686delTT, 1687delTG, 1688delGG, 1689delGC,       1690delCA, 1691delAG, 1692delGT, 1693delTT, 1694delTC, 1695delCA, 1696delAA,       1697delAA, 1698delAA, 1699delAG, 1700delGA, 1701delAC, 1702delCT, 1703delTC,       1704delCC, 1705delCT, 1706delTG, 1707delGA, 1708delAA, 1709delAA, 1710delAT,       1711delTG, 1712delGA, 1713delAT, 1714delTA, 1715delAA, 1716delAA, 1717delAT,       1718delTC, 1719delCA, 1720delAG, 1721delGG, 1722delGG, 1723delGA, 1724delAA,       1725delAC, 1726delCT, 1727delTA, 1728delAA, 1729delAC, 1730delCC, 1731delCA,       1732delAA, 1733delAA, 1734delAC, 1735delCG, 1736delGG, 1737delGA, 1738delAG,       1739delGC, 1740delCA, 1741delAG, 1742delGA, 1743delAA, 1744delAT, 1745delTG,       1746delGG, 1747delGT, 1748delTC, 1749delCA, 1750delAA, 1751delAG, 1752delGT,       1753delTG, 1754delGA, 1755delAT, 1756delTG, 1757delGA, 1758delAA, 1759delAT,       1760delTA, 1761delAT, 1762delTT, 1763delTA, 1764delAC, 1765delCT, 1766delTA,       1767delAA, 1768delAT, 1769delTA, 1770delAG, 1771delGT, 1772delTG, 1773delGG,       1774delGT, 1775delTC, 1776delCA, 1777delAT, 1778delTG, 1779delGA, 1780delAG,       1781delGA, 1782delAA, 1783delAT, 1784delTA, 1785delAA, 1786delAA, 1787delAA,       1788delAC, 1789delCA, 1790delAA, 1791delAA, 1792delAA, 1793delAG, 1794delGG,       1795delGT, 1796delTG, 1797delGA, 1798delAT, 1799delTT, 1800delTC, 1801delCT,       1802delTA, 1803delAT, 1804delTT, 1805delTC, 1806delCA, 1807delAG, 1808delGA,       1809delAA, 1810delAT, 1811delTG, 1812delGA, 1813delAG, 1814delGA, 1815delAA,       1816delAA, 1817delAA, 1818delAA, 1819delAT, 1820delTC, 1821delCC, 1822delCT,       1823delTA, 1824delAA, 1825delAC, 1826delCC, 1827delCC, 1828delCA, 1829delAA,       1830delAT, 1831delTA, 1832delAG, 1833delGA, 1834delAA, 1835delAT, 1836delTC,       1837delCA, 1838delAC, 1839delCT, 1840delTC, 1841delCG, 1842delGA, 1843delAA,       1844delAA, 1845delAA, 1846delAA, 1847delAG, 1848delGA, 1849delAA, 1850delAT,       1851delTC, 1852delCT, 1853delTG, 1854delGC, 1855delCT, 1856delTT, 1857delTT,       1858delTC, 1859delCA, 1860delAA, 1861delAA, 1862delAA, 1863delAC, 1864delCG,       1865delGA, 1866delAA, 1867delAA, 1868delAG, 1869delGC, 1870delCT, 1871delTG,       1872delGA, 1873delAA, 1874delAC, 1875delCC, 1876delCT, 1877delTA, 1878delAT,       1879delTA, 1880delAA, 1881delAG, 1882delGC, 1883delCA, 1884delAG, 1885delGC,       1886delCA, 1887delAG, 1888delGT, 1889delTA, 1890delAT, 1891delTA, 1892delAA,       1893delAG, 1894delGC, 1895delCA, 1896delAA, 1897delAT, 1898delTA, 1899delAT,       1900delTG, 1901delGG, 1902delGA, 1903delAA, 1904delAC, 1905delCT, 1906delTC,       1907delCG, 1908delGA, 1909delAA, 1910delAT, 1911delTT, 1912delTA, 1913delAA,       1914delAA, 1915delAT, 1916delTA, 1917delAT, 1918delTC, 1919delCC, 1920delCA,       1921delAC, 1922delCA, 1923delAA, 1924delAT, 1925delTT, 1926delTC, 1927delCA,       1928delAA, 1929delAA, 1930delAA, 1931delAG, 1932delGC, 1933delCA, 1934delAC,       1935delCC, 1936delCT, 1937delTA, 1938delAA, 1939delAA, 1940delAA, 1941delAA,       1942delAG, 1943delGA, 1944delAA, 1945delAT, 1946delTA, 1947delAG, 1948delGG,       1949delGC, 1950delCT, 1951delTG, 1952delGA, 1953delAG, 1954delGG, 1955delGA,       1956delAG, 1957delGG, 1958delGA, 1959delAA, 1960delAG, 1961delGT, 1962delTC,       1963delCT, 1964delTT, 1965delTC, 1966delCT, 1967delTA, 1968delAC, 1969delCC,       1970delCA, 1971delAG, 1972delGG, 1973delGC, 1974delCA, 1975delAT, 1976delTA,       1977delAT, 1978delTT, 1979delTC, 1980delCA, 1981delAT, 1982delTG, 1983delGC,       1984delCG, 1985delGC, 1986delCT, 1987delTT, 1988delTG, 1989delGA, 1990delAA,       1991delAC, 1992delCT, 1993delTA, 1994delAG, 1995delGT, 1996delTA, 1997delAG,       1998delGT, 1999delTC, 2000delCA, 2001delAG, 2002delGT, 2003delTA, 2004delAG,       2005delGA, 2006delAA, 2007delAA, 2008delAT, 2009delTC, 2010delCT, 2011delTA,       2012delAA, 2013delAG, 2014delGC, 2015delCC, 2016delCC, 2017delCA, 2018delAC,       2019delCC, 2020delCT, 2021delTA, 2022delAA, 2023delAT, 2024delTT, 2025delTG,       2026delGT, 2027delTA, 2028delAC, 2029delCT, 2030delTG, 2031delGA, 2032delAA,       2033delAT, 2034delTT, 2035delTG, 2036delGC, 2037delCA, 2038delAA, 2039delAA,       2040delAT, 2041delTT, 2042delTG, 2043delGA, 2044delAT, 2045delTA, 2046delAG,       2047delGT, 2048delTT, 2049delTG, 2050delGT, 2051delTT, 2052delTC, 2053delCT,       2054delTA, 2055delAG, 2056delGC, 2057delCA, 2058delAG, 2059delGT, 2060delTG,       2061delGA, 2062delAA, 2063delAG, 2064delGA, 2065delAG, 2066delGA, 2067delAT,       2068delTA, 2069delAA, 2070delAA, 2071delAG, 2072delGA, 2073delAA, 2074delAA,       2075delAA, 2076delAA, 2077delAA, 2078delAA, 2079delAA, 2080delAG, 2081delGT,       2082delTA, 2083delAC, 2084delCA, 2085delAA, 2086delAC, 2087delCC, 2088delCA,       2089delAA, 2090delAA, 2091delAT, 2092delTG, 2093delGC, 2094delCC, 2095delCA,       2096delAG, 2097delGT, 2098delTC, 2099delCA, 2100delAG, 2101delGG, 2102delGC,       2103delCA, 2104delAC, 2105delCA, 2106delAG, 2107delGC, 2108delCA, 2109delAG,       2110delGA, 2111delAA, 2112delAA, 2113delAC, 2114delCC, 2115delCT, 2116delTA,       2117delAC, 2118delCA, 2119delAA, 2120delAC, 2121delCT, 2122delTC, 2123delCA,       2124delAT, 2125delTG, 2126delGG, 2127delGA, 2128delAA, 2129delAG, 2130delGG,       2131delGT, 2132delTA, 2133delAA, 2134delAA, 2135delAG, 2136delGA, 2137delAA,       2138delAC, 2139delCC, 2140delCT, 2141delTG, 2142delGC, 2143delCA, 2144delAA,       2145delAC, 2146delCT, 2147delTG, 2148delGG, 2149delGA, 2150delAG, 2151delGC,       2152delCC, 2153delCA, 2154delAA, 2155delAG, 2156delGA, 2157delAA, 2158delAG,       2159delGA, 2160delAG, 2161delGT, 2162delTA, 2163delAA, 2164delAC, 2165delCA,       2166delAA, 2167delAG, 2168delGC, 2169delCC, 2170delCA, 2171delAA, 2172delAA,       2173delAT, 2174delTG, 2175delGA, 2176delAA, 2177delAC, 2178delCA, 2179delAG,       2180delGA, 2181delAC, 2182delCA, 2183delAA, 2184delAG, 2185delGT, 2186delTA,       2187delAA, 2188delAA, 2189delAA, 2190delAG, 2191delGA, 2192delAC, 2193delCA,       2194delAT, 2195delTG, 2196delGA, 2197delAC, 2198delCA, 2199delAG, 2200delGT,       2201delTG, 2202delGA, 2203delAT, 2204delTA, 2205delAC, 2206delCT, 2207delTT,       2208delTT, 2209delTC, 2210delCC, 2211delCC, 2212delCA, 2213delAG, 2214delGA,       2215delAG, 2216delGC, 2217delCT, 2218delTG, 2219delGA, 2220delAA, 2221delAG,       2222delGT, 2223delTT, 2224delTA, 2225delAA, 2226delAC, 2227delCA, 2228delAA,       2229delAA, 2230delAT, 2231delTG, 2232delGC, 2233delCA, 2234delAC, 2235delCC,       2236delCT, 2237delTG, 2238delGG, 2239delGT, 2240delTT, 2241delTC, 2242delCT,       2243delTT, 2244delTT, 2245delTT, 2246delTA, 2247delAC, 2248delCT, 2249delTA,       2250delAA, 2251delAG, 2252delGT, 2253delTG, 2254delGT, 2255delTT, 2256delTC,       2257delCA, 2258delAA, 2259delAA, 2260delAT, 2261delTA, 2262delAC, 2263delCC,       2264delCA, 2265delAG, 2266delGT, 2267delTG, 2268delGA, 2269delAA, 2270delAC,       2271delCT, 2272delTT, 2273delTA, 2274delAA, 2275delAA, 2276delAG, 2277delGA,       2278delAA, 2279delAT, 2280delTT, 2281delTT, 2282delTG, 2283delGT, 2284delTC,       2285delCA, 2286delAA, 2287delAT, 2288delTC, 2289delCC, 2290delCT, 2291delTA,       2292delAG, 2293delGC, 2294delCC, 2295delCT, 2296delTT, 2297delTC, 2298delCC,       2299delCA, 2300delAA, 2301delAG, 2302delGA, 2303delAG, 2304delGA, 2305delAA,       2306delAG, 2307delGA, 2308delAA, 2309delAA, 2310delAA, 2311delAA, 2312delAG,       2313delGA, 2314delAA, 2315delAG, 2316delGA, 2317delAG, 2318delGA, 2319delAA,       2320delAA, 2321delAC, 2322delCT, 2323delTA, 2324delAG, 2325delGA, 2326delAA,       2327delAA, 2328delAC, 2329delCA, 2330delAG, 2331delGT, 2332delTT, 2333delTA,       2334delAA, 2335delAA, 2336delAG, 2337delGT, 2338delTG, 2339delGT, 2340delTC,       2341delCT, 2342delTA, 2343delAA, 2344delAT, 2345delTA, 2346delAA, 2347delAT,       2348delTG, 2349delGC, 2350delCT, 2351delTG, 2352delGA, 2353delAA, 2354delAG,       2355delGA, 2356delAC, 2357delCC, 2358delCC, 2359delCC, 2360delCA, 2361delAA,       2362delAA, 2363delAG, 2364delGA, 2365delAT, 2366delTC, 2367delCT, 2368delTC,       2369delCA, 2370delAT, 2371delTG, 2372delGT, 2373delTT, 2374delTA, 2375delAA,       2376delAG, 2377delGT, 2378delTG, 2379delGG, 2380delGA, 2381delAG, 2382delGA,       2383delAA, 2384delAA, 2385delAG, 2386delGG, 2387delGG, 2388delGT, 2389delTT,       2390delTT, 2391delTT, 2392delTG, 2393delGC, 2394delCA, 2395delAA, 2396delAA,       2397delAC, 2398delCT, 2399delTG, 2400delGA, 2401delAA, 2402delAA, 2403delAG,       2404delGA, 2405delAT, 2406delTC, 2407delCT, 2408delTG, 2409delGT, 2410delTA,       2411delAG, 2412delGA, 2413delAG, 2414delGA, 2415delAG, 2416delGT, 2417delTA,       2418delAG, 2419delGC, 2420delCA, 2421delAG, 2422delGT, 2423delTA, 2424delAT,       2425delTT, 2426delTT, 2427delTC, 2428delCA, 2429delAC, 2430delCT, 2431delTG,       2432delGG, 2433delGT, 2434delTA, 2435delAC, 2436delCC, 2437delCT, 2438delTG,       2439delGG, 2440delGT, 2441delTA, 2442delAC, 2443delCT, 2444delTG, 2445delGA,       2446delAT, 2447delTT, 2448delTA, 2449delAT, 2450delTG, 2451delGG, 2452delGC,       2453delCA, 2454delAC, 2455delCT, 2456delTC, 2457delCA, 2458delAG, 2459delGG,       2460delGA, 2461delAA, 2462delAA, 2463delAG, 2464delGT, 2465delTA, 2466delAT,       2467delTC, 2468delCT, 2469delTC, 2470delCG, 2471delGT, 2472delTT, 2473delTA,       2474delAC, 2475delCT, 2476delTG, 2477delGG, 2478delGA, 2479delAA, 2480delAG,       2481delGT, 2482delTT, 2483delTA, 2484delAG, 2485delGC, 2486delCA, 2487delAC,       2488delCT, 2489delTC, 2490delCT, 2491delTA, 2492delAG, 2493delGG, 2494delGG,       2495delGA, 2496delAA, 2497delAG, 2498delGG, 2499delGC, 2500delCA, 2501delAA,       2502delAA, 2503delAA, 2504delAA, 2505delAC, 2506delCA, 2507delAG, 2508delGA,       2509delAA, 2510delAC, 2511delCC, 2512delCA, 2513delAA, 2514delAA, 2515delAT,       2516delTA, 2517delAA, 2518delAA, 2519delAT, 2520delTG, 2521delGT, 2522delTG,       2523delGT, 2524delTG, 2525delGA, 2526delAG, 2527delGT, 2528delTC, 2529delCA,       2530delAG, 2531delGT, 2532delTG, 2533delGT, 2534delTG, 2535delGC, 2536delCA,       2537delAG, 2538delGC, 2539delCA, 2540delAT, 2541delTT, 2542delTT, 2543delTG,       2544delGA, 2545delAA, 2546delAA, 2547delAA, 2548delAC, 2549delCC, 2550delCC,       2551delCC, 2552delCA, 2553delAA, 2554delAG, 2555delGG, 2556delGG, 2557delGA,       2558delAC, 2559delCT, 2560delTA, 2561delAA, 2562delAT, 2563delTT, 2564delTC,       2565delCA, 2566delAT, 2567delTG, 2568delGG, 2569delGT, 2570delTT, 2571delTG,       2572delGT, 2573delTT, 2574delTC, 2575delCC, 2576delCA, 2577delAA, 2578delAA,       2579delAG, 2580delGA, 2581delAT, 2582delTA, 2583delAA, 2584delAT, 2585delTA,       2586delAG, 2587delGA, 2588delAA, 2589delAA, 2590delAT, 2591delTG, 2592delGA,       2593delAC, 2594delCA, 2595delAC, 2596delCA, 2597delAG, 2598delGA, 2599delAA,       2600delAG, 2601delGG, 2602delGC, 2603delCT, 2604delTT, 2605delTT, 2606delTA,       2607delAA, 2608delAG, 2609delGT, 2610delTA, 2611delAT, 2612delTC, 2613delCC,       2614delCA, 2615delAT, 2616delTT, 2617delTG, 2618delGG, 2619delGG, 2620delGA,       2621delAC, 2622delCA, 2623delAT, 2624delTG, 2625delGA, 2626delAA, 2627delAG,       2628delGT, 2629delTT, 2630delTA, 2631delAA, 2632delAC, 2633delCC, 2634delCA,       2635delAC, 2636delCA, 2637delAG, 2638delGT, 2639delTC, 2640delCG, 2641delGG,       2642delGG, 2643delGA, 2644delAA, 2645delAA, 2646delAC, 2647delCA, 2648delAA,       2649delAG, 2650delGC, 2651delCA, 2652delAT, 2653delTA, 2654delAG, 2655delGA,       2656delAA, 2657delAA, 2658delAT, 2659delTG, 2660delGG, 2661delGA, 2662delAA,       2663delAG, 2664delGA, 2665delAA, 2666delAA, 2667delAG, 2668delGT, 2669delTG,       2670delGA, 2671delAA, 2672delAC, 2673delCT, 2674delTT, 2675delTG, 2676delGA,       2677delAT, 2678delTG, 2679delGC, 2680delCT, 2681delTC, 2682delCA, 2683delAG,       2684delGT, 2685delTA, 2686delAT, 2687delTT, 2688delTT, 2689delTG, 2690delGC,       2691delCA, 2692delAG, 2693delGA, 2694delAA, 2695delAT, 2696delTA, 2697delAC,       2698delCA, 2699delAT, 2700delTT, 2701delTC, 2702delCA, 2703delAA, 2704delAG,       2705delGG, 2706delGT, 2707delTT, 2708delTT, 2709delTC, 2710delCA, 2711delAA,       2712delAA, 2713delAG, 2714delGC, 2715delCG, 2716delGC, 2717delCC, 2718delCA,       2719delAG, 2720delGT, 2721delTC, 2722delCA, 2723delAT, 2724delTT, 2725delTT,       2726delTG, 2727delGC, 2728delCT, 2729delTC, 2730delCT, 2731delTG, 2732delGT,       2733delTT, 2734delTT, 2735delTT, 2736delTC, 2737delCA, 2738delAA, 2739delAA,       2740delAT, 2741delTC, 2742delCC, 2743delCA, 2744delAG, 2745delGG, 2746delGA,       2747delAA, 2748delAA, 2749delAT, 2750delTG, 2751delGC, 2752delCA, 2753delAG,       2754delGA, 2755delAA, 2756delAG, 2757delGA, 2758delAG, 2759delGG, 2760delGA,       2761delAA, 2762delAT, 2763delTG, 2764delGT, 2765delTG, 2766delGC, 2767delCA,       2768delAA, 2769delAC, 2770delCA, 2771delAT, 2772delTT, 2773delTC, 2774delCT,       2775delTC, 2776delCT, 2777delTG, 2778delGC, 2779delCC, 2780delCC, 2781delCA,       2782delAC, 2783delCT, 2784delTC, 2785delCT, 2786delTG, 2787delGG, 2788delGG,       2789delGT, 2790delTC, 2791delCC, 2792delCT, 2793delTT, 2794delTA, 2795delAA,       2796delAA, 2797delAG, 2798delGA, 2799delAA, 2800delAA, 2801delAC, 2802delCA,       2803delAA, 2804delAA, 2805delAG, 2806delGT, 2807delTC, 2808delCC, 2809delCA,       2810delAA, 2811delAA, 2812delAA, 2813delAG, 2814delGT, 2815delTC, 2816delCA,       2817delAC, 2818delCT, 2819delTT, 2820delTT, 2821delTT, 2822delTG, 2823delGA,       2824delAA, 2825delAT, 2826delTG, 2827delGT, 2828delTG, 2829delGA, 2830delAA,       2831delAC, 2832delCA, 2833delAA, 2834delAA, 2835delAA, 2836delAG, 2837delGG,       2838delGA, 2839delAA, 2840delAG, 2841delGA, 2842delAA, 2843delAA, 2844delAA,       2845delAT, 2846delTC, 2847delCA, 2848delAA, 2849delAG, 2850delGG, 2851delGA,       2852delAA, 2853delAA, 2854delAG, 2855delGA, 2856delAA, 2857delAT, 2858delTG,       2859delGA, 2860delAG, 2861delGT, 2862delTC, 2863delCT, 2864delTA, 2865delAA,       2866delAT, 2867delTA, 2868delAT, 2869delTC, 2870delCA, 2871delAA, 2872delAG,       2873delGC, 2874delCC, 2875delCT, 2876delTG, 2877delGT, 2878delTA, 2879delAC,       2880delCA, 2881delAG, 2882delGA, 2883delAC, 2884delCA, 2885delAG, 2886delGT,       2887delTT, 2888delTA, 2889delAA, 2890delAT, 2891delTA, 2892delAT, 2893delTC,       2894delCA, 2895delAC, 2896delCT, 2897delTG, 2898delGC, 2899delCA, 2900delAG,       2901delGG, 2902delGC, 2903delCT, 2904delTT, 2905delTT, 2906delTC, 2907delCC,       2908delCT, 2909delTG, 2910delGT, 2911delTG, 2912delGG, 2913delGT, 2914delTT,       2915delTG, 2916delGG, 2917delGT, 2918delTC, 2919delCA, 2920delAG, 2921delGA,       2922delAA, 2923delAA, 2924delAG, 2925delGA, 2926delAT, 2927delTA, 2928delAA,       2929delAG, 2930delGC, 2931delCC, 2932delCA, 2933delAG, 2934delGT, 2935delTT,       2936delTG, 2937delGA, 2938delAT, 2939delTA, 2940delAA, 2941delAT, 2942delTG,       2943delGC, 2944delCC, 2945delCA, 2946delAA, 2947delAA, 2948delAT, 2949delTG,       2950delGT, 2951delTA, 2952delAG, 2953delGT, 2954delTA, 2955delAT, 2956delTC,       2957delCA, 2958delAA, 2959delAA, 2960delAG, 2961delGG, 2962delGA, 2963delAG,       2964delGG, 2965delGC, 2966delCT, 2967delTC, 2968delCT, 2969delTA, 2970delAG,       2971delGG, 2972delGT, 2973delTT, 2974delTT, 2975delTT, 2976delTG, 2977delGT,       2978delTC, 2979delCT, 2980delTA, 2981delAT, 2982delTC, 2983delCA, 2984delAT,       2985delTC, 2986delCT, 2987delTC, 2988delCA, 2989delAG, 2990delGT, 2991delTT,       2992delTC, 2993delCA, 2994delAG, 2995delGA, 2996delAG, 2997delGG, 2998delGC,       2999delCA, 3000delAA, 3001delAC, 3002delCG, 3003delGA, 3004delAA, 3005delAA,       3006delAC, 3007delCT, 3008delTG, 3009delGG, 3010delGA, 3011delAC, 3012delCT,       3013delTC, 3014delCA, 3015delAT, 3016delTT, 3017delTA, 3018delAC, 3019delCT,       3020delTC, 3021delCC, 3022delCA, 3023delAA, 3024delAA, 3025delAT, 3026delTA,       3027delAA, 3028delAA, 3029delAC, 3030delCA, 3031delAT, 3032delTG, 3033delGG,       3034delGA, 3035delAC, 3036delCT, 3037delTT, 3038delTT, 3039delTT, 3040delTA,       3041delAC, 3042delCA, 3043delAA, 3044delAA, 3045delAA, 3046delAC, 3047delCC,       3048delCC, 3049delCA, 3050delAT, 3051delTA, 3052delAT, 3053delTC, 3054delCG,       3055delGT, 3056delTA, 3057delAT, 3058delTA, 3059delAC, 3060delCC, 3061delCA,       3062delAC, 3063delCC, 3064delCA, 3065delAC, 3066delCT, 3067delTT, 3068delTT,       3069delTT, 3070delTT, 3071delTC, 3072delCC, 3073delCC, 3074delCA, 3075delAT,       3076delTC, 3077delCA, 3078delAA, 3079delAG, 3080delGT, 3081delTC, 3082delCA,       3083delAT, 3084delTT, 3085delTT, 3086delTG, 3087delGT, 3088delTT, 3089delTA,       3090delAA, 3091delAA, 3092delAA, 3093delAC, 3094delCT, 3095delTA, 3096delAA,       3097delAA, 3098delAT, 3099delTG, 3100delGT, 3101delTA, 3102delAA, 3103delAG,       3104delGA, 3105delAA, 3106delAA, 3107delAA, 3108delAA, 3109delAT, 3110delTC,       3111delCT, 3112delTG, 3113delGC, 3114delCT, 3115delTA, 3116delAG, 3117delGA,       3118delAG, 3119delGG, 3120delGA, 3121delAA, 3122delAA, 3123delAA, 3124delAC,       3125delCT, 3126delTT, 3127delTT, 3128delTG, 3129delGA, 3130delAG, 3131delGG,       3132delGA, 3133delAA, 3134delAC, 3135delCA, 3136delAT, 3137delTT, 3138delTC,       3139delCA, 3140delAA, 3141delAT, 3142delTG, 3143delGT, 3144delTC, 3145delCA,       3146delAC, 3147delCC, 3148delCT, 3149delTG, 3150delGA, 3151delAA, 3152delAA,       3153delAG, 3154delGA, 3155delAG, 3156delGA, 3157delAA, 3158delAA, 3159delAT,       3160delTG, 3161delGG, 3162delGG, 3163delGA, 3164delAA, 3165delAA, 3166delAT,       3167delTG, 3168delGA, 3169delAG, 3170delGA, 3171delAA, 3172delAC, 3173delCA,       3174delAT, 3175delTT, 3176delTC, 3177delCC, 3178delCA, 3179delAA, 3180delAG,       3181delGT, 3182delTA, 3183delAC, 3184delCA, 3185delAG, 3186delGT, 3187delTG,       3188delGA, 3189delAG, 3190delGC, 3191delCA, 3192delAC, 3193delCA, 3194delAA,       3195delAT, 3196delTT, 3197delTA, 3198delAG, 3199delGC, 3200delCC, 3201delCG,       3202delGT, 3203delTA, 3204delAA, 3205delAT, 3206delTA, 3207delAA, 3208delAC,       3209delCA, 3210delAT, 3211delTT, 3212delTA, 3213delAG, 3214delGA, 3215delAG,       3216delGA, 3217delAA, 3218delAA, 3219delAA, 3220delAT, 3221delTG, 3222delGT,       3223delTT, 3224delTT, 3225delTT, 3226delTT, 3227delTA, 3228delAA, 3229delAA,       3230delAG, 3231delGG, 3232delGA, 3233delAG, 3234delGC, 3235delCC, 3236delCA,       3237delAG, 3238delGC, 3239delCT, 3240delTC, 3241delCA, 3242delAA, 3243delAG,       3244delGC, 3245delCA, 3246delAA, 3247delAT, 3248delTA, 3249delAT, 3250delTT,       3251delTA, 3252delAA, 3253delAT, 3254delTG, 3255delGA, 3256delAA, 3257delAG,       3258delGT, 3259delTA, 3260delAG, 3261delGG, 3262delGT, 3263delTT, 3264delTC,       3265delCC, 3266delCA, 3267delAG, 3268delGT, 3269delTA, 3270delAC, 3271delCT,       3272delTA, 3273delAA, 3274delAT, 3275delTG, 3276delGA, 3277delAA, 3278delAG,       3279delGT, 3280delTG, 3281delGG, 3282delGG, 3283delGC, 3284delCT, 3285delTC,       3286delCC, 3287delCA, 3288delAG, 3289delGT, 3290delTA, 3291delAT, 3292delTT,       3293delTA, 3294delAA, 3295delAT, 3296delTG, 3297delGA, 3298delAA, 3299delAA,       3300delAT, 3301delTA, 3302delAG, 3303delGG, 3304delGT, 3305delTT, 3306delTC,       3307delCC, 3308delCA, 3309delAG, 3310delGT, 3311delTG, 3312delGA, 3313delAT,       3314delTG, 3315delGA, 3316delAA, 3317delAA, 3318delAA, 3319delAC, 3320delCA,       3321delAT, 3322delTT, 3323delTC, 3324delCA, 3325delAA, 3326delAG, 3327delGC,       3328delCA, 3329delAG, 3330delGA, 3331delAA, 3332delAC, 3333delCT, 3334delTA,       3335delAG, 3336delGG, 3337delGT, 3338delTA, 3339delAG, 3340delGA, 3341delAA,       3342delAA, 3343delAC, 3344delCA, 3345delAG, 3346delGA, 3347delAG, 3348delGG,       3349delGG, 3350delGC, 3351delCC, 3352delCA, 3353delAA, 3354delAA, 3355delAA,       3356delAT, 3357delTT, 3358delTG, 3359delGA, 3360delAA, 3361delAT, 3362delTG,       3363delGC, 3364delCT, 3365delTA, 3366delAT, 3367delTG, 3368delGC, 3369delCT,       3370delTT, 3371delTA, 3372delAG, 3373delGA, 3374delAT, 3375delTT, 3376delTA,       3377delAG, 3378delGG, 3379delGG, 3380delGG, 3381delGT, 3382delTT, 3383delTT,       3384delTT, 3385delTG, 3386delGC, 3387delCA, 3388delAA, 3389delAC, 3390delCC,       3391delCT, 3392delTG, 3393delGA, 3394delAG, 3395delGG, 3396delGT, 3397delTC,       3398delCT, 3399delTA, 3400delAT, 3401delTA, 3402delAA, 3403delAA, 3404delAC,       3405delCA, 3406delAA, 3407delAA, 3408delAG, 3409delGT, 3410delTC, 3411delCT,       3412delTT, 3413delTC, 3414delCC, 3415delCT, 3416delTG, 3417delGG, 3418delGA,       3419delAA, 3420delAG, 3421delGT, 3422delTA, 3423delAA, 3424delAT, 3425delTT,       3426delTG, 3427delGT, 3428delTA, 3429delAA, 3430delAG, 3431delGC, 3432delCA,       3433delAT, 3434delTC, 3435delCC, 3436delCT, 3437delTG, 3438delGA, 3439delAA,       3440delAA, 3441delAT, 3442delTA, 3443delAA, 3444delAA, 3445delAA, 3446delAA,       3447delAA, 3448delAG, 3449delGC, 3450delCA, 3451delAA, 3452delAG, 3453delGA,       3454delAA, 3455delAT, 3456delTA, 3457delAT, 3458delTG, 3459delGA, 3460delAA,       3461delAG, 3462delGA, 3463delAA, 3464delAG, 3465delGT, 3466delTA, 3467delAG,       3468delGT, 3469delTT, 3470delTC, 3471delCA, 3472delAG, 3473delGA, 3474delAC,       3475delCT, 3476delTG, 3477delGT, 3478delTT, 3479delTA, 3480delAA, 3481delAT,       3482delTA, 3483delAC, 3484delCA, 3485delAG, 3486delGA, 3487delAT, 3488delTT,       3489delTT, 3490delTC, 3491delCT, 3492delTC, 3493delCT, 3494delTC, 3495delCC,       3496delCA, 3497delAT, 3498delTA, 3499delAT, 3500delTC, 3501delCT, 3502delTG,       3503delGA, 3504delAT, 3505delTT, 3506delTT, 3507delTC, 3508delCA, 3509delAG,       3510delGA, 3511delAT, 3512delTA, 3513delAA, 3514delAC, 3515delCT, 3516delTT,       3517delTA, 3518delAG, 3519delGA, 3520delAA, 3521delAC, 3522delCA, 3523delAG,       3524delGC, 3525delCC, 3526delCT, 3527delTA, 3528delAT, 3529delTG, 3530delGG,       3531delGG, 3532delGA, 3533delAA, 3534delAG, 3535delGT, 3536delTA, 3537delAG,       3538delGT, 3539delTC, 3540delCA, 3541delAT, 3542delTG, 3543delGC, 3544delCA,       3545delAT, 3546delTC, 3547delCT, 3548delTC, 3549delCA, 3550delAG, 3551delGG,       3552delGT, 3553delTT, 3554delTT, 3555delTG, 3556delGT, 3557delTT, 3558delTC,       3559delCT, 3560delTG, 3561delGA, 3562delAG, 3563delGA, 3564delAC, 3565delCA,       3566delAC, 3567delCC, 3568delCT, 3569delTG, 3570delGA, 3571delAT, 3572delTG,       3573delGA, 3574delAC, 3575delCC, 3576delCT, 3577delTG, 3578delGT, 3579delTT,       3580delTA, 3581delAG, 3582delGA, 3583delAT, 3584delTG, 3585delGA, 3586delAT,       3587delTG, 3588delGG, 3589delGT, 3590delTG, 3591delGA, 3592delAA, 3593delAA,       3594delAT, 3595delTA, 3596delAA, 3597delAA, 3598delAG, 3599delGG, 3600delGA,       3601delAA, 3602delAG, 3603delGA, 3604delAT, 3605delTA, 3606delAC, 3607delCT,       3608delTA, 3609delAG, 3610delGT, 3611delTT, 3612delTT, 3613delTT, 3614delTG,       3615delGC, 3616delCT, 3617delTG, 3618delGA, 3619delAA, 3620delAA, 3621delAA,       3622delAT, 3623delTG, 3624delGA, 3625delAC, 3626delCA, 3627delAT, 3628delTT,       3629delTA, 3630delAA, 3631delAG, 3632delGG, 3633delGA, 3634delAA, 3635delAA,       3636delAG, 3637delGT, 3638delTT, 3639delTC, 3640delCT, 3641delTG, 3642delGC,       3643delCT, 3644delTG, 3645delGT, 3646delTT, 3647delTT, 3648delTT, 3649delTT,       3650delTA, 3651delAG, 3652delGC, 3653delCA, 3654delAA, 3655delAA, 3656delAA,       3657delAG, 3658delGC, 3659delCG, 3660delGT, 3661delTC, 3662delCC, 3663delCA,       3664delAG, 3665delGA, 3666delAG, 3667delGA, 3668delAG, 3669delGG, 3670delGA,       3671delAG, 3672delGA, 3673delAG, 3674delGC, 3675delCT, 3676delTT, 3677delTA,       3678delAG, 3679delGC, 3680delCA, 3681delAG, 3682delGG, 3683delGA, 3684delAG,       3685delGT, 3686delTC, 3687delCC, 3688delCT, 3689delTA, 3690delAG, 3691delGC,       3692delCC, 3693delCC, 3694delCT, 3695delTT, 3696delTT, 3697delTC, 3698delCA,       3699delAC, 3700delCC, 3701delCC, 3702delCA, 3703delAT, 3704delTA, 3705delAC,       3706delCA, 3707delAC, 3708delCA, 3709delAT, 3710delTT, 3711delTT, 3712delTG,       3713delGG, 3714delGC, 3715delCT, 3716delTC, 3717delCA, 3718delAG, 3719delGG,       3720delGG, 3721delGT, 3722delTT, 3723delTA, 3724delAC, 3725delCC, 3726delCG,       3727delGA, 3728delAA, 3729delAG, 3730delGA, 3731delAG, 3732delGG, 3733delGG,       3734delGG, 3735delGC, 3736delCC, 3737delCA, 3738delAA, 3739delAG, 3740delGA,       3741delAA, 3742delAA, 3743delAT, 3744delTT, 3745delTA, 3746delAG, 3747delGA,       3748delAG, 3749delGT, 3750delTC, 3751delCC, 3752delCT, 3753delTC, 3754delCA,       3755delAG, 3756delGA, 3757delAA, 3758delAG, 3759delGA, 3760delAG, 3761delGA,       3762delAA, 3763delAC, 3764delCT, 3765delTT, 3766delTA, 3767delAT, 3768delTC,       3769delCT, 3770delTA, 3771delAG, 3772delGT, 3773delTG, 3774delGA, 3775delAG,       3776delGG, 3777delGA, 3778delAT, 3779delTG, 3780delGA, 3781delAA, 3782delAG,       3783delGA, 3784delAG, 3785delGC, 3786delCT, 3787delTT, 3788delTC, 3789delCC,       3790delCC, 3791delCT, 3792delTG, 3793delGC, 3794delCT, 3795delTT, 3796delTC,       3797delCC, 3798delCA, 3799delAA, 3800delAC, 3801delCA, 3802delAC, 3803delCT,       3804delTT, 3805delTG, 3806delGT, 3807delTT, 3808delTA, 3809delAT, 3810delTT,       3811delTT, 3812delTG, 3813delGG, 3814delGT, 3815delTA, 3816delAA, 3817delAA,       3818delAG, 3819delGT, 3820delTA, 3821delAA, 3822delAA, 3823delAC, 3824delCA,       3825delAA, 3826delAT, 3827delTA, 3828delAT, 3829delTA, 3830delAC, 3831delCC,       3832delCT, 3833delTT, 3834delTC, 3835delCT, 3836delTC, 3837delCA, 3838delAG,       3839delGT, 3840delTC, 3841delCT, 3842delTA, 3843delAC, 3844delCT, 3845delTA,       3846delAG, 3847delGG, 3848delGC, 3849delCA, 3850delAT, 3851delTA, 3852delAG,       3853delGC, 3854delCA, 3855delAC, 3856delCC, 3857delCG, 3858delGT, 3859delTT,       3860delTG, 3861delGC, 3862delCT, 3863delTA, 3864delAC, 3865delCC, 3866delCG,       3867delGA, 3868delAG, 3869delGT, 3870delTG, 3871delGT, 3872delTC, 3873delCT,       3874delTG, 3875delGT, 3876delTC, 3877delCT, 3878delTA, 3879delAA, 3880delAG,       3881delGA, 3882delAA, 3883delAC, 3884delCA, 3885delAC, 3886delCA, 3887delAG,       3888delGA, 3889delAG, 3890delGG, 3891delGA, 3892delAG, 3893delGA, 3894delAA,       3895delAT, 3896delTT, 3897delTT, 3898delTA, 3899delAT, 3900delTT, 3901delTA,       3902delAT, 3903delTC, 3904delCA, 3905delAT, 3906delTT, 3907delTG, 3908delGA,       3909delAA, 3910delAG, 3911delGA, 3912delAA, 3913delAT, 3914delTA, 3915delAG,       3916delGC, 3917delCT, 3918delTT, 3919delTA, 3920delAA, 3921delAA, 3922delAT,       3923delTG, 3924delGA, 3925delAC, 3926delCT, 3927delTG, 3928delGC, 3929delCA,       3930delAG, 3931delGT, 3932delTA, 3933delAA, 3934delAC, 3935delCC, 3936delCA,       3937delAG, 3938delGG, 3939delGT, 3940delTA, 3941delAA, 3942delAT, 3943delTA,       3944delAT, 3945delTT, 3946delTG, 3947delGG, 3948delGC, 3949delCA, 3950delAA,       3951delAA, 3952delAG, 3953delGG, 3954delGC, 3955delCA, 3956delAT, 3957delTC,       3958delCT, 3959delTC, 3960delCA, 3961delAG, 3962delGG, 3963delGA, 3964delAA,       3965delAC, 3966delCA, 3967delAT, 3968delTC, 3969delCA, 3970delAC, 3971delCC,       3972delCT, 3973delTT, 3974delTA, 3975delAG, 3976delGT, 3977delTG, 3978delGA,       3979delAG, 3980delGG, 3981delGA, 3982delAA, 3983delAA, 3984delAC, 3985delCA,       3986delAA, 3987delAA, 3988delAA, 3989delAT, 3990delTG, 3991delGT, 3992delTT,       3993delTC, 3994delCT, 3995delTG, 3996delGC, 3997delCT, 3998delTA, 3999delAG,       4000delGC, 4001delCT, 4002delTT, 4003delTG, 4004delGT, 4005delTT, 4006delTT,       4007delTT, 4008delTC, 4009delCT, 4010delTT, 4011delTC, 4012delCA, 4013delAC,       4014delCA, 4015delAG, 4016delGT, 4017delTG, 4018delGC, 4019delCA, 4020delAG,       4021delGT, 4022delTG, 4023delGA, 4024delAA, 4025delAT, 4026delTT, 4027delTG,       4028delGG, 4029delGA, 4030delAA, 4031delAG, 4032delGA, 4033delAC, 4034delCT,       4035delTT, 4036delTG, 4037delGA, 4038delAC, 4039delCT, 4040delTG, 4041delGC,       4042delCA, 4043delAA, 4044delAA, 4045delAT, 4046delTA, 4047delAC, 4048delCA,       4049delAA, 4050delAA, 4051delAC, 4052delCA, 4053delAC, 4054delCC, 4055delCC,       4056delCA, 4057delAG, 4058delGG, 4059delGA, 4060delAT, 4061delTC, 4062delCC,       4063delCT, 4064delTT, 4065delTT, 4066delTC, 4067delCT, 4068delTT, 4069delTG,       4070delGA, 4071delAT, 4072delTT, 4073delTG, 4074delGG, 4075delGT, 4076delTT,       4077delTC, 4078delCT, 4079delTT, 4080delTC, 4081delCC, 4082delCA, 4083delAA,       4084delAA, 4085delAC, 4086delCA, 4087delAA, 4088delAA, 4089delAT, 4090delTG,       4091delGA, 4092delAG, 4093delGG, 4094delGC, 4095delCA, 4096delAT, 4097delTC,       4098delCA, 4099delAG, 4100delGT, 4101delTC, 4102delCT, 4103delTG, 4104delGA,       4105delAA, 4106delAA, 4107delAG, 4108delGC, 4109delCC, 4110delCA, 4111delAG,       4112delGG, 4113delGG, 4114delGA, 4115delAG, 4116delGT, 4117delTT, 4118delTG,       4119delGG, 4120delGT, 4121delTC, 4122delCT, 4123delTG, 4124delGA, 4125delAG,       4126delGT, 4127delTG, 4128delGA, 4129delAC, 4130delCA, 4131delAA, 4132delAG,       4133delGG, 4134delGA, 4135delAA, 4136delAT, 4137delTT, 4138delTG, 4139delGG,       4140delGT, 4141delTT, 4142delTT, 4143delTC, 4144delCA, 4145delAG, 4146delGA,       4147delAT, 4148delTG, 4149delGA, 4150delAT, 4151delTG, 4152delGA, 4153delAA,       4154delAG, 4155delGA, 4156delAA, 4157delAA, 4158delAG, 4159delGA, 4160delAG,       4161delGG, 4162delGA, 4163delAA, 4164delAC, 4165delCG, 4166delGG, 4167delGG,       4168delGC, 4169delCT, 4170delTT, 4171delTG, 4172delGG, 4173delGA, 4174delAA,       4175delAG, 4176delGA, 4177delAA, 4178delAA, 4179delAA, 4180delAT, 4181delTA,       4182delAA, 4183delAT, 4184delTC, 4185delCA, 4186delAA, 4187delAG, 4188delGA,       4189delAA, 4190delAG, 4191delGA, 4192delAG, 4193delGC, 4194delCA, 4195delAA,       4196delAA, 4197delAG, 4198delGC, 4199delCA, 4200delAT, 4201delTG, 4202delGG,       4203delGA, 4204delAT, 4205delTT, 4206delTC, 4207delCA, 4208delAA, 4209delAA,       4210delAC, 4211delCT, 4212delTT, 4213delTA, 4214delAG, 4215delGG, 4216delGT,       4217delTG, 4218delGA, 4219delAA, 4220delAG, 4221delGC, 4222delCA, 4223delAG,       4224delGC, 4225delCA, 4226delAT, 4227delTC, 4228delCT, 4229delTG, 4230delGG,       4231delGG, 4232delGT, 4233delTG, 4234delGT, 4235delTG, 4236delGA, 4237delAG,       4238delGA, 4239delAG, 4240delGT, 4241delTG, 4242delGA, 4243delAA, 4244delAA,       4245delAC, 4246delCA, 4247delAA, 4248delAG, 4249delGC, 4250delCG, 4251delGT,       4252delTC, 4253delCT, 4254delTC, 4255delCT, 4256delTG, 4257delGA, 4258delAA,       4259delAG, 4260delGA, 4261delAC, 4262delCT, 4263delTG, 4264delGC, 4265delCT,       4266delTC, 4267delCA, 4268delAG, 4269delGG, 4270delGG, 4271delGC, 4272delCT,       4273delTA, 4274delAT, 4275delTC, 4276delCC, 4277delCT, 4278delTC, 4279delCT,       4280delTC, 4281delCA, 4282delAG, 4283delGA, 4284delAG, 4285delGT, 4286delTG,       4287delGA, 4288delAC, 4289delCA, 4290delAT, 4291delTT, 4292delTT, 4293delTT,       4294delTA, 4295delAA, 4296delAC, 4297delCC, 4298delCA, 4299delAC, 4300delCT,       4301delTC, 4302delCA, 4303delAG, 4304delGC, 4305delCA, 4306delAG, 4307delGA,       4308delAG, 4309delGG, 4310delGG, 4311delGA, 4312delAT, 4313delTA, 4314delAC,       4315delCC, 4316delCA, 4317delAT, 4318delTG, 4319delGC, 4320delCA, 4321delAA,       4322delAC, 4323delCA, 4324delAT, 4325delTA, 4326delAA, 4327delAC, 4328delCC,       4329delCT, 4330delTG, 4331delGA, 4332delAT, 4333delTA, 4334delAA, 4335delAA,       4336delAG, 4337delGC, 4338delCT, 4339delTC, 4340delCC, 4341delCA, 4342delAG,       4343delGC, 4344delCA, 4345delAG, 4346delGG, 4347delGA, 4348delAA, 4349delAA,       4350delAT, 4351delTG, 4352delGG, 4353delGC, 4354delCT, 4355delTG, 4356delGA,       4357delAA, 4358delAC, 4359delCT, 4360delTA, 4361delAG, 4362delGA, 4363delAA,       4364delAG, 4365delGC, 4366delCT, 4367delTG, 4368delGT, 4369delTG, 4370delGT,       4371delTT, 4372delTA, 4373delAG, 4374delGA, 4375delAA, 4376delAC, 4377delCA,       4378delAG, 4379delGC, 4380delCA, 4381delAT, 4382delTG, 4383delGG, 4384delGG,       4385delGA, 4386delAG, 4387delGC, 4388delCC, 4389delCA, 4390delAG, 4391delGC,       4392delCC, 4393delCT, 4394delTT, 4395delTC, 4396delCT, 4397delTA, 4398delAA,       4399delAC, 4400delCA, 4401delAG, 4402delGC, 4403delCT, 4404delTA, 4405delAC,       4406delCC, 4407delCC, 4408delCT, 4409delTT, 4410delTC, 4411delCC, 4412delCA,       4413delAT, 4414delTC, 4415delCA, 4416delAT, 4417delTA, 4418delAA, 4419delAG,       4420delGT, 4421delTG, 4422delGA, 4423delAC, 4424delCT, 4425delTC, 4426delCC,       4427delCT, 4428delTC, 4429delCT, 4430delTG, 4431delGC, 4432delCC, 4433delCC,       4434delCT, 4435delTT, 4436delTG, 4437delGA, 4438delAG, 4439delGG, 4440delGA,       4441delAC, 4442delCC, 4443delCT, 4444delTG, 4445delGC, 4446delCG, 4447delGA,       4448delAA, 4449delAA, 4450delAT, 4451delTC, 4452delCC, 4453delCA, 4454delAG,       4455delGA, 4456delAA, 4457delAC, 4458delCA, 4459delAA, 4460delAA, 4461delAG,       4462delGC, 4463delCA, 4464delAC, 4465delCA, 4466delAT, 4467delTC, 4468delCA,       4469delAG, 4470delGA, 4471delAA, 4472delAA, 4473delAA, 4474delAA, 4475delAG,       4476delGC, 4477delCA, 4478delAG, 4479delGT, 4480delTA, 4481delAT, 4482delTT,       4483delTA, 4484delAA, 4485delAC, 4486delCT, 4487delTT, 4488delTC, 4489delCA,       4490delAC, 4491delCA, 4492delAG, 4493delGA, 4494delAA, 4495delAA, 4496delAA,       4497delAG, 4498delGT, 4499delTA, 4500delAG, 4501delGT, 4502delTG, 4503delGA,       4504delAA, 4505delAT, 4506delTA, 4507delAC, 4508delCC, 4509delCC, 4510delCT,       4511delTA, 4512delAT, 4513delTA, 4514delAA, 4515delAG, 4516delGC, 4517delCC,       4518delCA, 4519delAG, 4520delGA, 4521delAA, 4522delAT, 4523delTC, 4524delCC,       4525delCA, 4526delAG, 4527delGA, 4528delAA, 4529delAG, 4530delGG, 4531delGC,       4532delCC, 4533delCT, 4534delTT, 4535delTT, 4536delTC, 4537delCT, 4538delTG,       4539delGC, 4540delCT, 4541delTG, 4542delGA, 4543delAC, 4544delCA, 4545delAA,       4546delAG, 4547delGT, 4548delTT, 4549delTT, 4550delTG, 4551delGA, 4552delAG,       4553delGG, 4554delGT, 4555delTG, 4556delGT, 4557delTC, 4558delCT, 4559delTG,       4560delGC, 4561delCA, 4562delAG, 4563delGA, 4564delAT, 4565delTA, 4566delAG,       4567delGT, 4568delTT, 4569delTC, 4570delCT, 4571delTA, 4572delAC, 4573delCC,       4574delCA, 4575delAG, 4576delGT, 4577delTA, 4578delAA, 4579delAA, 4580delAA,       4581delAA, 4582delAT, 4583delTA, 4584delAA, 4585delAA, 4586delAG, 4587delGA,       4588delAA, 4589delAC, 4590delCC, 4591delCA, 4592delAG, 4593delGG, 4594delGA,       4595delAG, 4596delGT, 4597delTG, 4598delGG, 4599delGA, 4600delAA, 4601delAA,       4602delAG, 4603delGG, 4604delGT, 4605delTC, 4606delCA, 4607delAT, 4608delTC,       4609delCC, 4610delCC, 4611delCC, 4612delCT, 4613delTT, 4614delTC, 4615delCT,       4616delTA, 4617delAA, 4618delAA, 4619delAT, 4620delTG, 4621delGC, 4622delCC,       4623delCC, 4624delCA, 4625delAT, 4626delTC, 4627delCA, 4628delAT, 4629delTT,       4630delTA, 4631delAG, 4632delGA, 4633delAT, 4634delTG, 4635delGA, 4636delAT,       4637delTA, 4638delAG, 4639delGG, 4640delGT, 4641delTG, 4642delGG, 4643delGT,       4644delTA, 4645delAC, 4646delCA, 4647delAT, 4648delTG, 4649delGC, 4650delCA,       4651delAC, 4652delCA, 4653delAG, 4654delGT, 4655delTT, 4656delTG, 4657delGC,       4658delCT, 4659delTC, 4660delCT, 4661delTG, 4662delGG, 4663delGG, 4664delGA,       4665delAG, 4666delGT, 4667delTC, 4668delCT, 4669delTT, 4670delTC, 4671delCA,       4672delAG, 4673delGA, 4674delAA, 4675delAT, 4676delTA, 4677delAG, 4678delGA,       4679delAA, 4680delAA, 4681delAC, 4682delCT, 4683delTA, 4684delAC, 4685delCC,       4686delCC, 4687delCA, 4688delAT, 4689delTC, 4690delCT, 4691delTC, 4692delCA,       4693delAA, 4694delAG, 4695delGA, 4696delAG, 4697delGG, 4698delGA, 4699delAG,       4700delGC, 4701delCT, 4702delTC, 4703delCA, 4704delAT, 4705delTT, 4706delTA,       4707delAA, 4708delAG, 4709delGG, 4710delGT, 4711delTT, 4712delTG, 4713delGT,       4714delTT, 4715delTG, 4716delGA, 4717delAT, 4718delTG, 4719delGT, 4720delTG,       4721delGG, 4722delGA, 4723delAG, 4724delGG, 4725delGA, 4726delAG, 4727delGC,       4728delCA, 4729delAA, 4730delAC, 4731delCA, 4732delAG, 4733delGC, 4734delCT,       4735delTG, 4736delGG, 4737delGA, 4738delAA, 4739delAG, 4740delGA, 4741delAG,       4742delGT, 4743delTC, 4744delCT, 4745delTG, 4746delGG, 4747delGG, 4748delGC,       4749delCC, 4750delCA, 4751delAC, 4752delCA, 4753delAC, 4754delCG, 4755delGA,       4756delAT, 4757delTT, 4758delTT, 4759delTG, 4760delGA, 4761delAC, 4762delCG,       4763delGG, 4764delGA, 4765delAA, 4766delAA, 4767delAC, 4768delCA, 4769delAT,       4770delTC, 4771delCT, 4772delTT, 4773delTA, 4774delAC, 4775delCT, 4776delTT,       4777delTG, 4778delGC, 4779delCC, 4280delCA, 4781delAA, 4782delAG, 4783delGG,       4784delGC, 4785delCA, 4786delAA, 4787delAG, 4788delGA, 4789delAT, 4790delTC,       4791delCT, 4792delTA, 4793delAG, 4794delGA, 4795delAG, 4796delGG, 4797delGG,       4798delGA, 4799delAA, 4800delAC, 4801delCC, 4802delCC, 4803delCC, 4804delCT,       4805delTT, 4806delTA, 4807delAC, 4808delCC, 4809delCT, 4810delTG, 4811delGG,       4812delGA, 4813delAA, 4814delAT, 4815delTC, 4816delCT, 4817delTG, 4818delGG,       4819delGA, 4820delAA, 4821delAT, 4822delTC, 4823delCA, 4824delAG, 4825delGC,       4826delCC, 4827delCT, 4828delTC, 4829delCT, 4830delTT, 4831delTC, 4832delCT,       4833delTC, 4834delCT, 4835delTG, 4836delGA, 4837delAT, 4838delTG, 4839delGA,       4840delAC, 4841delCC, 4842delCC, 4843delCT, 4844delTG, 4845delGA, 4846delAA,       4847delAT, 4848delTC, 4849delCT, 4850delTG, 4851delGA, 4852delAT, 4853delTC,       4854delCC, 4855delCT, 4856delTT, 4857delTC, 4858delCT, 4859delTG, 4860delGA,       4861delAA, 4862delAG, 4863delGA, 4864delAC, 4865delCA, 4866delAG, 4867delGA,       4868delAG, 4869delGC, 4870delCC, 4871delCC, 4872delCC, 4873delCA, 4874delAG,       4875delGA, 4876delAG, 4877delGT, 4878delTC, 4879delCA, 4880delAG, 4881delGC,       4882delCT, 4883delTC, 4884delCG, 4885delGT, 4886delTG, 4887delGT, 4888delTT,       4889delTG, 4890delGG, 4891delGC, 4892delCA, 4893delAA, 4894delAC, 4895delCA,       4896delAT, 4897delTA, 4898delAC, 4899delCC, 4900delCA, 4901delAT, 4902delTC,       4903delCT, 4904delTT, 4905delTC, 4906delCA, 4907delAA, 4908delAC, 4909delCC,       4910delCT, 4911delTC, 4912delCT, 4913delTG, 4914delGC, 4915delCA, 4916delAT,       4917delTT, 4918delTG, 4919delGA, 4920delAA, 4921delAA, 4922delAG, 4923delGT,       4924delTT, 4925delTC, 4926delCC, 4927delCC, 4928delCC, 4929delCA, 4930delAA,       4931delAT, 4932delTT, 4933delTG, 4934delGA, 4935delAA, 4936delAA, 4937delAG,       4938delGT, 4939delTT, 4940delTG, 4941delGC, 4942delCA, 4943delAG, 4944delGA,       4945delAA, 4946delAT, 4947delTC, 4948delCT, 4949delTG, 4950delGC, 4951delCC,       4952delCC, 4953delCA, 4954delAG, 4955delGG, 4956delGG, 4957delGT, 4958delTC,       4959delCC, 4960delCA, 4961delAG, 4962delGC, 4963delCT, 4964delTG, 4965delGC,       4966delCT, 4967delTG, 4968delGC, 4969delCT, 4970delTC, 4971delCA, 4972delAT,       4973delTA, 4974delAC, 4975delCT, 4976delTA, 4977delAC, 4978delCT, 4979delTG,       4980delGA, 4981delAT, 4982delTA, 4983delAC, 4984delCT, 4985delTG, 4986delGC,       4987delCT, 4988delTG, 4989delGG, 4990delGG, 4991delGT, 4992delTA, 4993delAT,       4994delTA, 4995delAA, 4996delAT, 4997delTG, 4998delGC, 4999delCA, 5000delAA,       5001delAT, 5002delTG, 5003delGG, 5004delGA, 5005delAA, 5006delAG, 5007delGA,       5008delAA, 5009delAA, 5010delAG, 5011delGT, 5012delTG, 5013delGT, 5014delTG,       5015delGA, 5016delAG, 5017delGC, 5018delCA, 5019delAG, 5020delGG, 5021delGG,       5022delGA, 5023delAG, 5024delGA, 5025delAA, 5026delAG, 5027delGC, 5028delCC,       5029delCA, 5030delAG, 5031delGA, 5032delAA, 5033delAT, 5034delTT, 5035delTG,       5036delGA, 5037delAC, 5038delCA, 5039delAG, 5040delGC, 5041delCT, 5042delTT,       5043delTC, 5044delCA, 5045delAA, 5046delAC, 5047delCA, 5048delAG, 5049delGA,       5050delAA, 5051delAA, 5052delAG, 5053delGG, 5054delGG, 5055delGT, 5056delTC,       5057delCA, 5058delAA, 5059delAC, 5060delCA, 5061delAA, 5062delAA, 5063delAA,       5064delAG, 5065delGA, 5066delAA, 5067delAT, 5068delTG, 5069delGT, 5070delTC,       5071delCC, 5072delCA, 5073delAT, 5074delTG, 5075delGG, 5076delGT, 5077delTG,       5078delGG, 5079delGT, 5080delTG, 5081delGT, 5082delTC, 5083delCT, 5084delTG,       5085delGG, 5086delGC, 5087delCC, 5088delCT, 5089delTG, 5090delGA, 5091delAC,       5092delCC, 5093delCC, 5094delCC, 5095delCA, 5096delAG, 5097delGA, 5098delAA,       5099delAG, 5100delGA, 5101delAA, 5102delAT, 5103delTT, 5104delTT, 5105delTA,       5106delAT, 5107delTG, 5108delGC, 5109delCT, 5110delTC, 5111delCG, 5112delGT,       5113delTG, 5114delGT, 5115delTA, 5116delAC, 5117delCA, 5118delAA, 5119delAG,       5120delGT, 5121delTT, 5122delTT, 5123delTG, 5124delGC, 5125delCC, 5126delCA,       5127delAG, 5128delGA, 5129delAA, 5130delAA, 5131delAA, 5132delAC, 5133delCA,       5134delAC, 5135delCC, 5136delCA, 5137delAC, 5138delCA, 5139delAT, 5140delTC,       5141delCA, 5142delAC, 5143delCT, 5144delTT, 5145delTT, 5146delTA, 5147delAA,       5148delAC, 5149delCT, 5150delTA, 5151delAA, 5152delAT, 5153delTC, 5154delCT,       5155delTA, 5156delAA, 5157delAT, 5158delTT, 5159delTA, 5160delAC, 5161delCT,       5162delTG, 5163delGA, 5164delAA, 5165delAG, 5166delGA, 5167delAG, 5168delGA,       5169delAC, 5170delCT, 5171delTA, 5172delAC, 5173delCT, 5174delTC, 5175delCA,       5176delAT, 5177delTG, 5178delGT, 5179delTT, 5180delTG, 5181delGT, 5182delTT,       5183delTA, 5184delAT, 5185delTG, 5186delGA, 5187delAA, 5188delAA, 5189delAA,       5190delAC, 5191delCA, 5192delAG, 5193delGA, 5194delAT, 5195delTG, 5196delGC,       5197delCT, 5198delTG, 5199delGA, 5200delAG, 5201delGT, 5202delTT, 5203delTT,       5204delTG, 5205delGT, 5206delTG, 5207delGT, 5208delTG, 5209delGT, 5210delTG,       5211delGA, 5212delAA, 5213delAC, 5214delCG, 5215delGG, 5216delGA, 5217delAC,       5218delCA, 5219delAC, 5220delCT, 5221delTG, 5222delGA, 5223delAA, 5224delAA,       5225delAT, 5226delTA, 5227delAT, 5228delTT, 5229delTT, 5230delTT, 5231delTC,       5232delCT, 5233delTA, 5234delAG, 5235delGG, 5236delGA, 5237delAA, 5238delAT,       5239delTT, 5240delTG, 5241delGC, 5242delCG, 5243delGG, 5244delGG, 5245delGA,       5246delAG, 5247delGG, 5248delGA, 5249delAA, 5250delAA, 5251delAA, 5252delAT,       5253delTG, 5254delGG, 5255delGG, 5256delGT, 5257delTA, 5258delAG, 5259delGT,       5260delTT, 5261delTA, 5262delAG, 5263delGC, 5264delCT, 5265delTA, 5266delAT,       5267delTT, 5268delTT, 5269delTC, 5270delCT, 5271delTG, 5272delGG, 5273delGG,       5274delGT, 5275delTG, 5276delGA, 5277delAC, 5278delCC, 5279delCC, 5280delCA,       5281delAG, 5282delGT, 5283delTC, 5284delCT, 5285delTA, 5286delAT, 5287delTT,       5288delTA, 5289delAA, 5290delAA, 5291delAG, 5292delGA, 5293delAA, 5294delAA,       5295delAG, 5296delGA, 5297delAA, 5298delAA, 5299delAA, 5300delAA, 5301delAT,       5302delTG, 5303delGC, 5304delCT, 5305delTG, 5306delGA, 5307delAA, 5308delAT,       5309delTG, 5310delGA, 5311delAG, 5312delGC, 5313delCA, 5314delAT, 5315delTG,       5316delGA, 5317delAT, 5318delTT, 5319delTT, 5320delTT, 5321delTG, 5322delGA,       5323delAA, 5324delAG, 5325delGT, 5126delTC, 5327delCA, 5328delAG, 5329delGA,       5330delAG, 5331delGG, 5332delGA, 5333delAG, 5334delGA, 5335delAT, 5336delTG,       5337delGT, 5338delTG, 5339delGG, 5340delGT, 5341delTC, 5342delCA, 5343delAA,       5344delAT, 5345delTG, 5346delGG, 5347delGA, 5348delAA, 5349delAG, 5350delGA,       5351delAA, 5352delAA, 5353delAC, 5354delCC, 5355delCA, 5356delAC, 5357delCC,       5358delCA, 5359delAA, 5360delAG, 5361delGG, 5362delGT, 5363delTC, 5364delCC,       5365delCA, 5366delAA, 5367delAA, 5368delAG, 5369delGC, 5370delCG, 5371delGA,       5372delAG, 5373delGC, 5374delCA, 5375delAA, 5376delAG, 5377delGA, 5378delAG,       5379delGA, 5380delAA, 5381delAT, 5382delTC, 5383delCC, 5384delCC, 5385delCA,       5386delAG, 5387delGG, 5388delGA, 5389delAC, 5390delCA, 5391delAG, 5392delGA,       5393delAA, 5394delAA, 5395delAG, 5396delGA, 5397delAT, 5398delTC, 5399delCT,       5400delTT, 5401delTC, 5402delCA, 5403delAG, 5404delGG, 5405delGG, 5406delGG,       5407delGG, 5408delGC, 5409delCT, 5410delTA, 5411delAG, 5412delGA, 5413delAA,       5414delAA, 5415delAT, 5416delTC, 5417delCT, 5418delTG, 5419delGT, 5420delTT,       5421delTG, 5422delGC, 5423delCT, 5424delTA, 5425delAT, 5426delTG, 5427delGG,       5428delGG, 5429delGC, 5430delCC, 5431delCC, 5432delCT, 5433delTT, 5434delTC,       5435delCA, 5436delAC, 5437delCC, 5438delCA, 5439delAA, 5440delAC, 5441delCA,       5442delAT, 5443delTG, 5444delGC, 5445delCC, 5446delCC, 5447delCA, 5448delAC,       5449delCA, 5450delAG, 5451delGA, 5452delAT, 5453delTC, 5454delCA, 5455delAA,       5456delAC, 5457delCT, 5458delTG, 5459delGG, 5460delGA, 5461delAA, 5462delAT,       5463delTG, 5464delGG, 5465delGA, 5466delAT, 5467delTG, 5468delGG, 5469delGT,       5470delTA, 5471delAC, 5472delCA, 5473delAG, 5474delGC, 5475delCT, 5476delTG,       5477delGT, 5478delTG, 5479delGT, 5480delTG, 5481delGG, 5482delGT, 5483delTG,       5484delGC, 5485delCT, 5486delTT, 5487delTC, 5488delCT, 5489delTG, 5490delGT,       5491delTG, 5492delGG, 5493delGT, 5494delTG, 5495delGA, 5496delAA, 5497delAG,       5498delGG, 5499delGA, 5500delAG, 5501delGC, 5502delCT, 5503delTT, 5504delTT,       5505delTC, 5506delCA, 5507delAT, 5508delTC, 5509delCA, 5510delAT, 5511delTT,       5512delTC, 5513delCA, 5514delAC, 5515delCC, 5516delCC, 5517delCT, 5518delTT,       5519delTG, 5520delGG, 5521delGC, 5522delCA, 5523delAC, 5524delCA, 5525delAG,       5526delGG, 5527delGT, 5528delTG, 5529delGT, 5530delTC, 5531delCC, 5532delCA,       5533delAC, 5534delCC, 5535delCC, 5536delCA, 5537delAA, 5538delAT, 5539delTT,       5540delTG, 5541delGT, 5542delTG, 5543delGG, 5544delGT, 5545delTT, 5546delTG,       5547delGT, 5548delTG, 5549delGC, 5550delCA, 5551delAG, 5552delGC, 5553delCC,       5554delCA, 5555delAG, 5556delGA, 5557delAT, 5558delTG, 5559delGC, 5560delCC,       5561delCT, 5562delTG, 5563delGG, 5564delGA, 5565delAC, 5566delCA, 5567delAG,       5568delGA, 5569delAG, 5570delGG, 5571delGA, 5572delAC, 5573delCA, 5574delAA,       5575delAT, 5576delTG, 5577delGG, 5578delGC, 5579delCT, 5580delTT, 5581delTC,       5582delCC, 5583delCA, 5584delAT, 5585delTG, 5586delGC, 5587delCA, 5588delAA,       5589delAT, 5590delTT, 5591delTG, 5592delGG, 5593delGG, 5594delGC, 5595delCA,       5596delAG, 5597delGA, 5598delAT, 5599delTG, 5600delGT, 5601delTG, 5602delGT,       5603delTG, 5635delTG, 5654delCC, 5660delCC, 5708delCT.                    
     [0229]               TABLE 11                       List of One Base Insertions       (N = A, T, G, or C)                                    122insN, 123insN, 124insN, 125insN, 126insN, 127insN, 128insN, 129insN, 130insN, 131insN,       132insN, 133insN, 134insN, 135insN, 136insN, 137insN, 138insN, 139insN, 140insN, 141insN,       142insN, 143insN, 144insN, 145insN, 146insN, 147insN, 148insN, 149insN, 150insN, 151insN,       152insN, 153insN, 154insN, 155insN, 156insN, 157insN, 158insN, 159insN, 160insN, 161insN,       162insN, 163insN, 164insN, 165insN, 166insN, 167insN, 168insN, 169insN, 170insN, 171insN,       172insN, 173insN, 174insN, 175insN, 176insN, 177insN, 178insN, 179insN, 180insN, 181insN,       182insN, 183insN, 184insN, 185insN, 186insN, 187insN, 188insN, 189insN, 190insN, 191insN,       192insN, 193insN, 194insN, 195insN, 196insN, 197insN, 198insN, 199insN, 200insN, 201insN,       202insN, 203insN, 204insN, 205insN, 206insN, 207insN, 208insN, 209insN, 210insN, 211insN,       212insN, 213insN, 214insN, 215insN, 216insN, 217insN, 218insN, 219insN, 220insN, 221insN,       222insN, 223insN, 224insN, 225insN, 226insN, 227insN, 228insN, 229insN, 230insN, 231insN,       232insN, 233insN, 234insN, 235insN, 236insN, 237insN, 238insN, 239insN, 240insN, 241insN,       242insN, 243insN, 244insN, 245insN, 246insN, 247insN, 248insN, 249insN, 250insN, 251insN,       252insN, 253insN, 254insN, 255insN, 256insN, 257insN, 258insN, 259insN, 260insN, 261insN,       262insN, 263insN, 264insN, 265insN, 266insN, 267insN, 268insN, 269insN, 270insN, 271insN,       272insN, 273insN, 274insN, 275insN, 276insN, 277insN, 278insN, 279insN, 280insN, 281insN,       282insN, 283insN, 284insN, 285insN, 286insN, 287insN, 288insN, 289insN, 290insN, 291insN,       292insN, 293insN, 294insN, 295insN, 296insN, 297insN, 298insN, 299insN, 300insN, 301insN,       302insN, 303insN, 304insN, 305insN, 306insN, 307insN, 308insN, 309insN, 310insN, 311insN,       312insN, 313insN, 314insN, 315insN, 316insN, 317insN, 318insN, 319insN, 320insN, 321insN,       322insN, 323insN, 324insN, 325insN, 326insN, 327insN, 328insN, 329insN, 330insN, 331insN,       332insN, 333insN, 334insN, 335insN, 336insN, 337insN, 338insN, 339insN, 340insN, 341insN,       342insN, 343insN, 344insN, 345insN, 346insN, 347insN, 348insN, 349insN, 350insN, 351insN,       352insN, 353insN, 354insN, 355insN, 356insN, 357insN, 358insN, 359insN, 360insN, 361insN,       362insN, 363insN, 364insN, 365insN, 366insN, 367insN, 368insN, 369insN, 370insN, 371insN,       372insN, 373insN, 374insN, 375insN, 376insN, 377insN, 378insN, 379insN, 380insN, 381insN,       382insN, 383insN, 384insN, 385insN, 386insN, 387insN, 388insN, 389insN, 390insN, 391insN,       392insN, 393insN, 394insN, 395insN, 396insN, 397insN, 398insN, 399insN, 400insN, 401insN,       402insN, 403insN, 404insN, 405insN, 406insN, 407insN, 408insN, 409insN, 410insN, 411insN,       412insN, 413insN, 414insN, 415insN, 416insN, 417insN, 418insN, 419insN, 420insN, 421insN,       422insN, 423insN, 424insN, 425insN, 426insN, 427insN, 428insN, 429insN, 430insN, 431insN,       432insN, 433insN, 434insN, 435insN, 436insN, 437insN, 438insN, 439insN, 440insN, 441insN,       442insN, 443insN, 444insN, 445insN, 446insN, 447insN, 448insN, 449insN, 450insN, 451insN,       452insN, 453insN, 454insN, 455insN, 456insN, 457insN, 458insN, 459insN, 460insN, 461insN,       462insN, 463insN, 464insN, 465insN, 466insN, 467insN, 468insN, 469insN, 470insN, 471insN,       472insN, 473insN, 474insN, 475insN, 476insN, 477insN, 478insN, 479insN, 480insN, 481insN,       482insN, 483insN, 484insN, 485insN, 486insN, 487insN, 488insN, 489insN, 490insN, 491insN,       492insN, 493insN, 494insN, 495insN, 496insN, 497insN, 498insN, 499insN, 500insN, 501insN,       502insN, 503insN, 504insN, 505insN, 506insN, 507insN, 508insN, 509insN, 510insN, 511insN,       512insN, 513insN, 514insN, 515insN, 516insN, 517insN, 518insN, 519insN, 520insN, 521insN,       522insN, 523insN, 524insN, 525insN, 526insN, 527insN, 528insN, 529insN, 530insN, 531insN,       532insN, 533insN, 534insN, 535insN, 536insN, 537insN, 538insN, 539insN, 540insN, 541insN,       542insN, 543insN, 544insN, 545insN, 546insN, 547insN, 548insN, 549insN, 550insN, 551insN,       552insN, 553insN, 554insN, 555insN, 556insN, 557insN, 558insN, 559insN, 560insN, 561insN,       562insN, 563insN, 564insN, 565insN, 566insN, 567insN, 568insN, 569insN, 570insN, 571insN,       572insN, 573insN, 574insN, 575insN, 576insN, 577insN, 578insN, 579insN, 580insN, 581insN,       582insN, 583insN, 584insN, 585insN, 586insN, 587insN, 588insN, 589insN, 590insN, 591insN,       592insN, 593insN, 594insN, 595insN, 596insN, 597insN, 598insN, 599insN, 600insN, 601insN,       602insN, 603insN, 604insN, 605insN, 606insN, 607insN, 608insN, 609insN, 610insN, 611insN,       612insN, 613insN, 614insN, 615insN, 616insN, 617insN, 618insN, 619insN, 620insN, 621insN,       622insN, 623insN, 624insN, 625insN, 626insN, 627insN, 628insN, 629insN, 630insN, 631insN,       632insN, 633insN, 634insN, 635insN, 636insN, 637insN, 638insN, 639insN, 640insN, 641insN,       642insN, 643insN, 644insN, 645insN, 646insN, 647insN, 648insN, 649insN, 650insN, 651insN,       652insN, 653insN, 654insN, 655insN, 656insN, 657insN, 658insN, 659insN, 660insN, 661insN,       662insN, 663insN, 664insN, 665insN, 666insN, 667insN, 668insN, 669insN, 670insN, 671insN,       672insN, 673insN, 674insN, 675insN, 676insN, 677insN, 678insN, 679insN, 680insN, 681insN,       682insN, 683insN, 684insN, 685insN, 686insN, 687insN, 688insN, 689insN, 690insN, 691insN,       692insN, 693insN, 694insN, 695insN, 696insN, 697insN, 698insN, 699insN, 700insN, 701insN,       702insN, 703insN, 704insN, 705insN, 706insN, 707insN, 708insN, 709insN, 710insN, 711insN,       712insN, 713insN, 714insN, 715insN, 716insN, 717insN, 718insN, 719insN, 720insN, 721insN,       722insN, 723insN, 724insN, 725insN, 726insN, 727insN, 728insN, 729insN, 730insN, 731insN,       732insN, 733insN, 734insN, 735insN, 736insN, 737insN, 738insN, 739insN, 740insN, 741insN,       742insN, 743insN, 744insN, 745insN, 746insN, 747insN, 748insN, 749insN, 750insN, 751insN,       752insN, 753insN, 754insN, 755insN, 756insN, 757insN, 758insN, 759insN, 760insN, 761insN,       762insN, 763insN, 764insN, 765insN, 766insN, 767insN, 768insN, 769insN, 770insN, 771insN,       772insN, 773insN, 774insN, 775insN, 776insN, 777insN, 778insN, 779insN, 780insN, 781insN,       782insN, 783insN, 784insN, 785insN, 786insN, 787insN, 788insN, 789insN, 790insN, 791insN,       792insN, 793insN, 794insN, 795insN, 796insN, 797insN, 798insN, 799insN, 800insN, 801insN,       802insN, 803insN, 804insN, 805insN, 806insN, 807insN, 808insN, 809insN, 810insN, 811insN,       812insN, 813insN, 814insN, 815insN, 816insN, 817insN, 818insN, 819insN, 820insN, 821insN,       822insN, 823insN, 824insN, 825insN, 826insN, 827insN, 828insN, 829insN, 830insN, 831insN,       832insN, 833insN, 834insN, 835insN, 836insN, 837insN, 838insN, 839insN, 840insN, 841insN,       842insN, 843insN, 844insN, 845insN, 846insN, 847insN, 848insN, 849insN, 850insN, 851insN,       852insN, 853insN, 854insN, 855insN, 856insN, 857insN, 858insN, 859insN, 860insN, 861insN,       862insN, 863insN, 864insN, 865insN, 866insN, 867insN, 868insN, 869insN, 870insN, 871insN,       872insN, 873insN, 874insN, 875insN, 876insN, 877insN, 878insN, 879insN, 880insN, 881insN,       882insN, 883insN, 884insN, 885insN, 886insN, 887insN, 888insN, 889insN, 890insN, 891insN,       892insN, 893insN, 894insN, 895insN, 896insN, 897insN, 898insN, 899insN, 900insN, 901insN,       902insN, 903insN, 904insN, 905insN, 906insN, 907insN, 908insN, 909insN, 910insN, 911insN,       912insN, 913insN, 914insN, 915insN, 916insN, 917insN, 918insN, 919insN, 920insN, 921insN,       922insN, 923insN, 924insN, 925insN, 926insN, 927insN, 928insN, 929insN, 930insN, 931insN,       932insN, 933insN, 934insN, 935insN, 936insN, 937insN, 938insN, 939insN, 940insN, 941insN,       942insN, 943insN, 944insN, 945insN, 946insN, 947insN, 948insN, 949insN, 950insN, 951insN,       952insN, 953insN, 954insN, 955insN, 956insN, 957insN, 958insN, 959insN, 960insN, 961insN,       962insN, 963insN, 964insN, 965insN, 966insN, 967insN, 968insN, 969insN, 970insN, 971insN,       972insN, 973insN, 974insN, 975insN, 976insN, 977insN, 978insN, 979insN, 980insN, 981insN,       982insN, 983insN, 984insN, 985insN, 986insN, 987insN, 988insN, 989insN, 990insN, 991insN,       992insN, 993insN, 994insN, 995insN, 996insN, 997insN, 998insN, 999insN, 1000insN,       1001insN, 1002insN, 1003insN, 1004insN, 1005insN, 1006insN, 1007insN, 1008insN,       1009insN, 1010insN, 1011insN, 1012insN, 1013insN, 1014insN, 1015insN, 1016insN,       1017insN, 1018insN, 1019insN, 1020insN, 1021insN, 1022insN, 1023insN, 1024insN,       1025insN, 1026insN, 1027insN, 1028insN, 1029insN, 1030insN, 1031insN, 1032insN,       1033insN, 1034insN, 1035insN, 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5110insN, 5111insN, 5112insN,       5113insN, 5114insN, 5115insN, 5116insN, 5117insN, 5118insN, 5119insN, 5120insN,       5121insN, 5122insN, 5123insN, 5124insN, 5125insN, 5126insN, 5127insN, 5128insN,       5129insN, 5130insN, 5131insN, 5132insN, 5133insN, 5134insN, 5135insN, 5136insN,       5137insN, 5138insN, 5139insN, 5140insN, 5141insN, 5142insN, 5143insN, 5144insN,       5145insN, 5146insN, 5147insN, 5148insN, 5149insN, 5150insN, 5151insN, 5152insN,       5153insN, 5154insN, 5155insN, 5156insN, 5157insN, 5158insN, 5159insN, 5160insN,       5161insN, 5162insN, 5163insN, 5164insN, 5165insN, 5166insN, 5167insN, 5168insN,       5169insN, 5170insN, 5171insN, 5172insN, 5173insN, 5174insN, 5175insN, 5176insN,       5177insN, 5178insN, 5179insN, 5180insN, 5181insN, 5182insN, 5183insN, 5184insN,       5185insN, 5186insN, 5187insN, 5188insN, 5189insN, 5190insN, 5191insN, 5192insN,       5193insN, 5194insN, 5195insN, 5196insN, 5197insN, 5198insN, 5199insN, 5200insN,       5201insN, 5202insN, 5203insN, 5204insN, 5205insN, 5206insN, 5207insN, 5208insN,       5209insN, 5210insN, 5211insN, 5212insN, 5213insN, 5214insN, 5215insN, 5216insN,       5217insN, 5218insN, 5219insN, 5220insN, 5221insN, 5222insN, 5223insN, 5224insN,       5225insN, 5226insN, 5227insN, 5228insN, 5229insN, 5230insN, 5231insN, 5232insN,       5233insN, 5234insN, 5235insN, 5236insN, 5237insN, 5238insN, 5239insN, 5240insN,       5241insN, 5242insN, 5243insN, 5244insN, 5245insN, 5246insN, 5247insN, 5248insN,       5249insN, 5250insN, 5251insN, 5252insN, 5253insN, 5254insN, 5255insN, 5256insN,       5257insN, 5258insN, 5259insN, 5260insN, 5261insN, 5262insN, 5263insN, 5264insN,       5265insN, 5266insN, 5267insN, 5268insN, 5269insN, 5270insN, 5271insN, 5272insN,       5273insN, 5274insN, 5275insN, 5276insN, 5277insN, 5278insN, 5279insN, 5280insN,       5281insN, 5282insN, 5283insN, 5284insN, 5285insN, 5286insN, 5287insN, 5288insN,       5289insN, 5290insN, 5291insN, 5292insN, 5293insN, 5294insN, 5295insN, 5296insN,       5297insN, 5298insN, 5299insN, 5300insN, 5301insN, 5302insN, 5303insN, 5304insN,       5305insN, 5306insN, 5307insN, 5308insN, 5309insN, 5310insN, 5311insN, 5312insN,       5313insN, 5314insN, 5315insN, 5316insN, 5317insN, 5318insN, 5319insN, 5320insN,       5321insN, 5322insN, 5323insN, 5324insN, 5325insN, 5326insN, 5327insN, 5328insN,       5329insN, 5330insN, 5331insN, 5332insN, 5333insN, 5334insN, 5335insN, 5336insN,       5337insN, 5338insN, 5339insN, 5340insN, 5341insN, 5342insN, 5343insN, 5344insN,       5345insN, 5346insN, 5347insN, 5348insN, 5349insN, 5350insN, 5351insN, 5352insN,       5353insN, 5354insN, 5355insN, 5356insN, 5357insN, 5358insN, 5359insN, 5360insN,       5361insN, 5362insN, 5363insN, 5364insN, 5365insN, 5366insN, 5367insN, 5368insN,       5369insN, 5370insN, 5371insN, 5372insN, 5373insN, 5374insN, 5375insN, 5376insN,       5377insN, 5378insN, 5379insN, 5380insN, 5381insN, 5382insN, 5383insN, 5384insN,       5385insN, 5386insN, 5387insN, 5388insN, 5389insN, 5390insN, 5391insN, 5392insN,       5393insN, 5394insN, 5395insN, 5396insN, 5397insN, 5398insN, 5399insN, 5400insN,       5401insN, 5402insN, 5403insN, 5404insN, 5405insN, 5406insN, 5407insN, 5408insN,       5409insN, 5410insN, 5411insN, 5412insN, 5413insN, 5414insN, 5415insN, 5416insN,       5417insN, 5418insN, 5419insN, 5420insN, 5421insN, 5422insN, 5423insN, 5424insN,       5425insN, 5426insN, 5427insN, 5428insN, 5429insN, 5430insN, 5431insN, 5432insN,       5433insN, 5434insN, 5435insN, 5436insN, 5437insN, 5438insN, 5439insN, 5440insN,       5441insN, 5442insN, 5443insN, 5444insN, 5445insN, 5446insN, 5447insN, 5448insN,       5449insN, 5450insN, 5451insN, 5452insN, 5453insN, 5454insN, 5455insN, 5456insN,       5457insN, 5458insN, 5459insN, 5460insN, 5461insN, 5462insN, 5463insN, 5464insN,       5465insN, 5466insN, 5467insN, 5468insN, 5469insN, 5470insN, 5471insN, 5472insN,       5473insN, 5474insN, 5475insN, 5476insN, 5477insN, 5478insN, 5479insN, 5480insN,       5481insN, 5482insN, 5483insN, 5484insN, 5485insN, 5486insN, 5487insN, 5488insN,       5489insN, 5490insN, 5491insN, 5492insN, 5493insN, 5494insN, 5495insN, 5496insN,       5497insN, 5498insN, 5499insN, 5500insN, 5501insN, 5502insN, 5503insN, 5504insN,       5505insN, 5506insN, 5507insN, 5508insN, 5509insN, 5510insN, 5511insN, 5512insN,       5513insN, 5514insN, 5515insN, 5516insN, 5517insN, 5518insN, 5519insN, 5520insN,       5521insN, 5522insN, 5523insN, 5524insN, 5525insN, 5526insN, 5527insN, 5528insN,       5529insN, 5530insN, 5531insN, 5532insN, 5533insN, 5534insN, 5535insN, 5536insN,       5537insN, 5538insN, 5539insN, 5540insN, 5541insN, 5542insN, 5543insN, 5544insN,       5545insN, 5546insN, 5547insN, 5548insN, 5549insN, 5550insN, 5551insN, 5552insN,       5553insN, 5554insN, 5555insN, 5556insN, 5557insN, 5558insN, 5559insN, 5560insN,       5561insN, 5562insN, 5563insN, 5564insN, 5565insN, 5566insN, 5567insN, 5568insN,       5569insN, 5570insN, 5571insN, 5572insN, 5573insN, 5574insN, 5575insN, 5576insN,       5577insN, 5578insN, 5579insN, 5580insN, 5581insN, 5582insN, 5583insN, 5584insN,       5585insN, 5586insN, 5587insN, 5588insN, 5589insN, 5590insN, 5591insN, 5592insN,       5593insN, 5594insN, 5595insN, 5596insN, 5597insN, 5598insN, 5599insN, 5600insN,       5601insN, 5602insN, 5628insN, 5629insN, 5652insN, 5653insN, 5658insN, 5659insN,       5676insN, 5677insN, 5706insN, 5707insN.                    
     [0230]               TABLE 12                       List of Two Base Insertions       (NN = AA, AT, AG, AC, TA, TT, TG, TC, GA, GT, GG, GC, CA, CT, CG, or CC)                                    122insNN, 123insNN, 124insNN, 125insNN, 126insNN, 127insNN, 128insNN, 129insNN,       130insNN, 131insNN, 132insNN, 133insNN, 134insNN, 135insNN, 136insNN, 137insNN,       138insNN, 139insNN, 140insNN, 141insNN, 142insNN, 143insNN, 144insNN, 145insNN,       146insNN, 147insNN, 148insNN, 149insNN, 150insNN, 151insNN, 152insNN, 153insNN,       154insNN, 155insNN, 156insNN, 157insNN, 158insNN, 159insNN, 160insNN, 161insNN,       162insNN, 163insNN, 164insNN, 165insNN, 166insNN, 167insNN, 168insNN, 169insNN,       170insNN, 171insNN, 172insNN, 173insNN, 174insNN, 175insNN, 176insNN, 177insNN,       178insNN, 179insNN, 180insNN, 181insNN, 182insNN, 183insNN, 184insNN, 185insNN,       186insNN, 187insNN, 188insNN, 189insNN, 190insNN, 191insNN, 192insNN, 193insNN,       194insNN, 195insNN, 196insNN, 197insNN, 198insNN, 199insNN, 200insNN, 201insNN,       202insNN, 203insNN, 204insNN, 205insNN, 206insNN, 207insNN, 208insNN, 209insNN,       210insNN, 211insNN, 212insNN, 213insNN, 214insNN, 215insNN, 216insNN, 217insNN,       218insNN, 219insNN, 220insNN, 221insNN, 222insNN, 223insNN, 224insNN, 225insNN,       226insNN, 227insNN, 228insNN, 229insNN, 230insNN, 231insNN, 232insNN, 233insNN,       234insNN, 235insNN, 236insNN, 237insNN, 238insNN, 239insNN, 240insNN, 241insNN,       242insNN, 243insNN, 244insNN, 245insNN, 246insNN, 247insNN, 248insNN, 249insNN,       250insNN, 251insNN, 252insNN, 253insNN, 254insNN, 255insNN, 256insNN, 257insNN,       258insNN, 259insNN, 260insNN, 261insNN, 262insNN, 263insNN, 264insNN, 265insNN,       266insNN, 267insNN, 268insNN, 269insNN, 270insNN, 271insNN, 272insNN, 273insNN,       274insNN, 275insNN, 276insNN, 277insNN, 278insNN, 279insNN, 280insNN, 281insNN,       282insNN, 283insNN, 284insNN, 285insNN, 286insNN, 287insNN, 288insNN, 289insNN,       290insNN, 291insNN, 292insNN, 293insNN, 294insNN, 295insNN, 296insNN, 297insNN,       298insNN, 299insNN, 300insNN, 301insNN, 302insNN, 303insNN, 304insNN, 305insNN,       306insNN, 307insNN, 308insNN, 309insNN, 310insNN, 311insNN, 312insNN, 313insNN,       314insNN, 315insNN, 316insNN, 317insNN, 318insNN, 319insNN, 320insNN, 321insNN,       322insNN, 323insNN, 324insNN, 325insNN, 326insNN, 327insNN, 328insNN, 329insNN,       330insNN, 331insNN, 332insNN, 333insNN, 334insNN, 335insNN, 336insNN, 337insNN,       338insNN, 339insNN, 340insNN, 341insNN, 342insNN, 343insNN, 344insNN, 345insNN,       346insNN, 347insNN, 348insNN, 349insNN, 350insNN, 351insNN, 352insNN, 353insNN,       354insNN, 355insNN, 356insNN, 357insNN, 358insNN, 359insNN, 360insNN, 361insNN,       362insNN, 363insNN, 364insNN, 365insNN, 366insNN, 367insNN, 368insNN, 369insNN,       370insNN, 371insNN, 372insNN, 373insNN, 374insNN, 375insNN, 376insNN, 377insNN,       378insNN, 379insNN, 380insNN, 381insNN, 382insNN, 383insNN, 384insNN, 385insNN,       386insNN, 387insNN, 388insNN, 389insNN, 390insNN, 391insNN, 392insNN, 393insNN,       394insNN, 395insNN, 396insNN, 397insNN, 398insNN, 399insNN, 400insNN, 401insNN,       402insNN, 403insNN, 404insNN, 405insNN, 406insNN, 407insNN, 408insNN, 409insNN,       410insNN, 411insNN, 412insNN, 413insNN, 414insNN, 415insNN, 416insNN, 417insNN,       418insNN, 419insNN, 420insNN, 421insNN, 422insNN, 423insNN, 424insNN, 425insNN,       426insNN, 427insNN, 428insNN, 429insNN, 430insNN, 431insNN, 432insNN, 433insNN,       434insNN, 435insNN, 436insNN, 437insNN, 438insNN, 439insNN, 440insNN, 441insNN,       442insNN, 443insNN, 444insNN, 445insNN, 446insNN, 447insNN, 448insNN, 449insNN,       450insNN, 451insNN, 452insNN, 453insNN, 454insNN, 455insNN, 456insNN, 457insNN,       458insNN, 459insNN, 460insNN, 461insNN, 462insNN, 463insNN, 464insNN, 465insNN,       466insNN, 467insNN, 468insNN, 469insNN, 470insNN, 471insNN, 472insNN, 473insNN,       474insNN, 475insNN, 476insNN, 477insNN, 478insNN, 479insNN, 480insNN, 481insNN,       482insNN, 483insNN, 484insNN, 485insNN, 486insNN, 487insNN, 488insNN, 489insNN,       490insNN, 491insNN, 492insNN, 493insNN, 494insNN, 495insNN, 496insNN, 497insNN,       498insNN, 499insNN, 500insNN, 501insNN, 502insNN, 503insNN, 504insNN, 505insNN,       506insNN, 507insNN, 508insNN, 509insNN, 510insNN, 511insNN, 512insNN, 513insNN,       514insNN, 515insNN, 516insNN, 517insNN, 518insNN, 519insNN, 520insNN, 521insNN,       522insNN, 523insNN, 524insNN, 525insNN, 526insNN, 527insNN, 528insNN, 529insNN,       530insNN, 531insNN, 532insNN, 533insNN, 534insNN, 535insNN, 536insNN, 537insNN,       538insNN, 539insNN, 540insNN, 541insNN, 542insNN, 543insNN, 544insNN, 545insNN,       546insNN, 547insNN, 548insNN, 549insNN, 550insNN, 551insNN, 552insNN, 553insNN,       554insNN, 555insNN, 556insNN, 557insNN, 558insNN, 559insNN, 560insNN, 561insNN,       562insNN, 563insNN, 564insNN, 565insNN, 566insNN, 567insNN, 568insNN, 569insNN,       570insNN, 571insNN, 572insNN, 573insNN, 574insNN, 575insNN, 576insNN, 577insNN,       578insNN, 579insNN, 580insNN, 581insNN, 582insNN, 583insNN, 584insNN, 585insNN,       586insNN, 587insNN, 588insNN, 589insNN, 590insNN, 591insNN, 592insNN, 593insNN,       594insNN, 595insNN, 596insNN, 597insNN, 598insNN, 599insNN, 600insNN, 601insNN,       602insNN, 603insNN, 604insNN, 605insNN, 606insNN, 607insNN, 608insNN, 609insNN,       610insNN, 611insNN, 612insNN, 613insNN, 614insNN, 615insNN, 616insNN, 617insNN,       618insNN, 619insNN, 620insNN, 621insNN, 622insNN, 623insNN, 624insNN, 625insNN,       626insNN, 627insNN, 628insNN, 629insNN, 630insNN, 631insNN, 632insNN, 633insNN,       634insNN, 635insNN, 636insNN, 637insNN, 638insNN, 639insNN, 640insNN, 641insNN,       642insNN, 643insNN, 644insNN, 645insNN, 646insNN, 647insNN, 648insNN, 649insNN,       650insNN, 651insNN, 652insNN, 653insNN, 654insNN, 655insNN, 656insNN, 657insNN,       658insNN, 659insNN, 660insNN, 661insNN, 662insNN, 663insNN, 664insNN, 665insNN,       666insNN, 667insNN, 668insNN, 669insNN, 670insNN, 671insNN, 672insNN, 673insNN,       674insNN, 675insNN, 676insNN, 677insNN, 678insNN, 679insNN, 680insNN, 681insNN,       682insNN, 683insNN, 684insNN, 685insNN, 686insNN, 687insNN, 688insNN, 689insNN,       690insNN, 691insNN, 692insNN, 693insNN, 694insNN, 695insNN, 696insNN, 697insNN,       698insNN, 699insNN, 700insNN, 701insNN, 702insNN, 703insNN, 704insNN, 705insNN,       706insNN, 707insNN, 708insNN, 709insNN, 710insNN, 711insNN, 712insNN, 713insNN,       714insNN, 715insNN, 716insNN, 717insNN, 718insNN, 719insNN, 720insNN, 721insNN,       722insNN, 723insNN, 724insNN, 725insNN, 726insNN, 727insNN, 728insNN, 729insNN,       730insNN, 731insNN, 732insNN, 733insNN, 734insNN, 735insNN, 736insNN, 737insNN,       738insNN, 739insNN, 740insNN, 741insNN, 742insNN, 743insNN, 744insNN, 745insNN,       746insNN, 747insNN, 748insNN, 749insNN, 750insNN, 751insNN, 752insNN, 753insNN,       754insNN, 755insNN, 756insNN, 757insNN, 758insNN, 759insNN, 760insNN, 761insNN,       762insNN, 763insNN, 764insNN, 765insNN, 766insNN, 767insNN, 768insNN, 769insNN,       770insNN, 771insNN, 772insNN, 773insNN, 774insNN, 775insNN, 776insNN, 777insNN,       778insNN, 779insNN, 780insNN, 781insNN, 782insNN, 783insNN, 784insNN, 785insNN,       786insNN, 787insNN, 788insNN, 789insNN, 790insNN, 791insNN, 792insNN, 793insNN,       794insNN, 795insNN, 796insNN, 797insNN, 798insNN, 799insNN, 800insNN, 801insNN,       802insNN, 803insNN, 804insNN, 805insNN, 806insNN, 807insNN, 808insNN, 809insNN,       810insNN, 811insNN, 812insNN, 813insNN, 814insNN, 815insNN, 816insNN, 817insNN,       818insNN, 819insNN, 820insNN, 821insNN, 822insNN, 823insNN, 824insNN, 825insNN,       826insNN, 827insNN, 828insNN, 829insNN, 830insNN, 831insNN, 832insNN, 833insNN,       834insNN, 835insNN, 836insNN, 837insNN, 838insNN, 839insNN, 840insNN, 841insNN,       842insNN, 843insNN, 844insNN, 845insNN, 846insNN, 847insNN, 848insNN, 849insNN,       850insNN, 851insNN, 852insNN, 853insNN, 854insNN, 855insNN, 856insNN, 857insNN,       858insNN, 859insNN, 860insNN, 861insNN, 862insNN, 863insNN, 864insNN, 865insNN,       866insNN, 867insNN, 868insNN, 869insNN, 870insNN, 871insNN, 872insNN, 873insNN,       874insNN, 875insNN, 876insNN, 877insNN, 878insNN, 879insNN, 880insNN, 881insNN,       882insNN, 883insNN, 884insNN, 885insNN, 886insNN, 887insNN, 888insNN, 889insNN,       890insNN, 891insNN, 892insNN, 893insNN, 894insNN, 895insNN, 896insNN, 897insNN,       898insNN, 899insNN, 900insNN, 901insNN, 902insNN, 903insNN, 904insNN, 905insNN,       906insNN, 907insNN, 908insNN, 909insNN, 910insNN, 911insNN, 912insNN, 913insNN,       914insNN, 915insNN, 916insNN, 917insNN, 918insNN, 919insNN, 920insNN, 921insNN,       922insNN, 923insNN, 924insNN, 925insNN, 926insNN, 927insNN, 928insNN, 929insNN,       930insNN, 931insNN, 932insNN, 933insNN, 934insNN, 935insNN, 936insNN, 937insNN,       938insNN, 939insNN, 940insNN, 941insNN, 942insNN, 943insNN, 944insNN, 945insNN,       946insNN, 947insNN, 948insNN, 949insNN, 950insNN, 951insNN, 952insNN, 953insNN,       954insNN, 955insNN, 956insNN, 957insNN, 958insNN, 959insNN, 960insNN, 961insNN,       962insNN, 963insNN, 964insNN, 965insNN, 966insNN, 967insNN, 968insNN, 969insNN,       970insNN, 971insNN, 972insNN, 973insNN, 974insNN, 975insNN, 976insNN, 977insNN,       978insNN, 979insNN, 980insNN, 981insNN, 982insNN, 983insNN, 984insNN, 985insNN,       986insNN, 987insNN, 988insNN, 989insNN, 990insNN, 991insNN, 992insNN, 993insNN,       994insNN, 995insNN, 996insNN, 997insNN, 998insNN, 999insNN, 1000insNN, 1001insNN,       1002insNN, 1003insNN, 1004insNN, 1005insNN, 1006insNN, 1007insNN, 1008insNN,       1009insNN, 1010insNN, 1011insNN, 1012insNN, 1013insNN, 1014insNN, 1015insNN,       1016insNN, 1017insNN, 1018insNN, 1019insNN, 1020insNN, 1021insNN, 1022insNN,       1023insNN, 1024insNN, 1025insNN, 1026insNN, 1027insNN, 1028insNN, 1029insNN,       1030insNN, 1031insNN, 1032insNN, 1033insNN, 1034insNN, 1035insNN, 1036insNN,       1037insNN, 1038insNN, 1039insNN, 1040insNN, 1041insNN, 1042insNN, 1043insNN,       1044insNN, 1045insNN, 1046insNN, 1047insNN, 1048insNN, 1049insNN, 1050insNN,       1051insNN, 1052insNN, 1053insNN, 1054insNN, 1055insNN, 1056insNN, 1057insNN,       1058insNN, 1059insNN, 1060insNN, 1061insNN, 1062insNN, 1063insNN, 1064insNN,       1065insNN, 1066insNN, 1067insNN, 1068insNN, 1069insNN, 1070insNN, 1071insNN,       1072insNN, 1073insNN, 1074insNN, 1075insNN, 1076insNN, 1077insNN, 1078insNN,       1079insNN, 1080insNN, 1081insNN, 1082insNN, 1083insNN, 1084insNN, 1085insNN,       1086insNN, 1087insNN, 1088insNN, 1089insNN, 1090insNN, 1091insNN, 1092insNN,       1093insNN, 1094insNN, 1095insNN, 1096insNN, 1097insNN, 1098insNN, 1099insNN,       1100insNN, 1101insNN, 1102insNN, 1103insNN, 1104insNN, 1105insNN, 1106insNN,       1107insNN, 1108insNN, 1109insNN, 1110insNN, 1111insNN, 1112insNN, 1113insNN,       1114insNN, 1115insNN, 1116insNN, 1117insNN, 1118insNN, 1119insNN, 1120insNN,       1121insNN, 1122insNN, 1123insNN, 1124insNN, 1125insNN, 1126insNN, 1127insNN,       1128insNN, 1129insNN, 1130insNN, 1131insNN, 1132insNN, 1133insNN, 1134insNN,       1135insNN, 1136insNN, 1137insNN, 1138insNN, 1139insNN, 1140insNN, 1141insNN,       1142insNN, 1143insNN, 1144insNN, 1145insNN, 1146insNN, 1147insNN, 1148insNN,       1149insNN, 1150insNN, 1151insNN, 1152insNN, 1153insNN, 1154insNN, 1155insNN,       1156insNN, 1157insNN, 1158insNN, 1159insNN, 1160insNN, 1161insNN, 1162insNN,       1163insNN, 1164insNN, 1165insNN, 1166insNN, 1167insNN, 1168insNN, 1169insNN,       1170insNN, 1171insNN, 1172insNN, 1173insNN, 1174insNN, 1175insNN, 1176insNN,       1177insNN, 1178insNN, 1179insNN, 1180insNN, 1181insNN, 1182insNN, 1183insNN,       1184insNN, 1185insNN, 1186insNN, 1187insNN, 1188insNN, 1189insNN, 1190insNN,       1191insNN, 1192insNN, 1193insNN, 1194insNN, 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3967insNN, 3968insNN, 3969insNN,       3970insNN, 3971insNN, 3972insNN, 3973insNN, 3974insNN, 3975insNN, 3976insNN,       3977insNN, 3978insNN, 3979insNN, 3980insNN, 3981insNN, 3982insNN, 3983insNN,       3984insNN, 3985insNN, 3986insNN, 3987insNN, 3988insNN, 3989insNN, 3990insNN,       3991insNN, 3992insNN, 3993insNN, 3994insNN, 3995insNN, 3996insNN, 3997insNN,       3998insNN, 3999insNN, 4000insNN, 4001insNN, 4002insNN, 4003insNN, 4004insNN,       4005insNN, 4006insNN, 4007insNN, 4008insNN, 4009insNN, 4010insNN, 4011insNN,       4012insNN, 4013insNN, 4014insNN, 4015insNN, 4016insNN, 4017insNN, 4018insNN,       4019insNN, 4020insNN, 4021insNN, 4022insNN, 4023insNN, 4024insNN, 4025insNN,       4026insNN, 4027insNN, 4028insNN, 4029insNN, 4030insNN, 4031insNN, 4032insNN,       4033insNN, 4034insNN, 4035insNN, 4036insNN, 4037insNN, 4038insNN, 4039insNN,       4040insNN, 4041insNN, 4042insNN, 4043insNN, 4044insNN, 4045insNN, 4046insNN,       4047insNN, 4048insNN, 4049insNN, 4050insNN, 4051insNN, 4052insNN, 4053insNN,       4054insNN, 4055insNN, 4056insNN, 4057insNN, 4058insNN, 4059insNN, 4060insNN,       4061insNN, 4062insNN, 4063insNN, 4064insNN, 4065insNN, 4066insNN, 4067insNN,       4068insNN, 4069insNN, 4070insNN, 4071insNN, 4072insNN, 4073insNN, 4074insNN,       4075insNN, 4076insNN, 4077insNN, 4078insNN, 4079insNN, 4080insNN, 4081insNN,       4082insNN, 4083insNN, 4084insNN, 4085insNN, 4086insNN, 4087insNN, 4088insNN,       4089insNN, 4090insNN, 4091insNN, 4092insNN, 4093insNN, 4094insNN, 4095insNN,       4096insNN, 4097insNN, 4098insNN, 4099insNN, 4100insNN, 4101insNN, 4102insNN,       4103insNN, 4104insNN, 4105insNN, 4106insNN, 4107insNN, 4108insNN, 4109insNN,       4110insNN, 4111insNN, 4112insNN, 4113insNN, 4114insNN, 4115insNN, 4116insNN,       4117insNN, 4118insNN, 4119insNN, 4120insNN, 4121insNN, 4122insNN, 4123insNN,       4124insNN, 4125insNN, 4126insNN, 4127insNN, 4128insNN, 4129insNN, 4130insNN,       4131insNN, 4132insNN, 4133insNN, 4134insNN, 4135insNN, 4136insNN, 4137insNN,       4138insNN, 4139insNN, 4140insNN, 4141insNN, 4142insNN, 4143insNN, 4144insNN,       4145insNN, 4146insNN, 4147insNN, 4148insNN, 4149insNN, 4150insNN, 4151insNN,       4152insNN, 4153insNN, 4154insNN, 4155insNN, 4156insNN, 4157insNN, 4158insNN,       4159insNN, 4160insNN, 4161insNN, 4162insNN, 4163insNN, 4164insNN, 4165insNN,       4166insNN, 4167insNN, 4168insNN, 4169insNN, 4170insNN, 4171insNN, 4172insNN,       4173insNN, 4174insNN, 4175insNN, 4176insNN, 4177insNN, 4178insNN, 4179insNN,       4180insNN, 4181insNN, 4182insNN, 4183insNN, 4184insNN, 4185insNN, 4186insNN,       4187insNN, 4188insNN, 4189insNN, 4190insNN, 4191insNN, 4192insNN, 4193insNN,       4194insNN, 4195insNN, 4196insNN, 4197insNN, 4198insNN, 4199insNN, 4200insNN,       4201insNN, 4202insNN, 4203insNN, 4204insNN, 4205insNN, 4206insNN, 4207insNN,       4208insNN, 4209insNN, 4210insNN, 4211insNN, 4212insNN, 4213insNN, 4214insNN,       4215insNN, 4216insNN, 4217insNN, 4218insNN, 4219insNN, 4220insNN, 4221insNN,       4222insNN, 4223insNN, 4224insNN, 4225insNN, 4226insNN, 4227insNN, 4228insNN,       4229insNN, 4230insNN, 4231insNN, 4232insNN, 4233insNN, 4234insNN, 4235insNN,       4236insNN, 4237insNN, 4238insNN, 4239insNN, 4240insNN, 4241insNN, 4242insNN,       4243insNN, 4244insNN, 4245insNN, 4246insNN, 4247insNN, 4248insNN, 4249insNN,       4250insNN, 4251insNN, 4252insNN, 4253insNN, 4254insNN, 4255insNN, 4256insNN,       4257insNN, 4258insNN, 4259insNN, 4260insNN, 4261insNN, 4262insNN, 4263insNN,       4264insNN, 4265insNN, 4266insNN, 4267insNN, 4268insNN, 4269insNN, 4270insNN,       4271insNN, 4272insNN, 4273insNN, 4274insNN, 4275insNN, 4276insNN, 4277insNN,       4278insNN, 4279insNN, 4280insNN, 4281insNN, 4282insNN, 4283insNN, 4284insNN,       4285insNN, 4286insNN, 4287insNN, 4288insNN, 4289insNN, 4290insNN, 4291insNN,       4292insNN, 4293insNN, 4294insNN, 4295insNN, 4296insNN, 4297insNN, 4298insNN,       4299insNN, 4300insNN, 4301insNN, 4302insNN, 4303insNN, 4304insNN, 4305insNN,       4306insNN, 4307insNN, 4308insNN, 4309insNN, 4310insNN, 4311insNN, 4312insNN,       4313insNN, 4314insNN, 4315insNN, 4316insNN, 4317insNN, 4318insNN, 4319insNN,       4320insNN, 4321insNN, 4322insNN, 4323insNN, 4324insNN, 4325insNN, 4326insNN,       4327insNN, 4328insNN, 4329insNN, 4330insNN, 4331insNN, 4332insNN, 4333insNN,       4334insNN, 4335insNN, 4336insNN, 4337insNN, 4338insNN, 4339insNN, 4340insNN,       4341insNN, 4342insNN, 4343insNN, 4344insNN, 4345insNN, 4346insNN, 4347insNN,       4348insNN, 4349insNN, 4350insNN, 4351insNN, 4352insNN, 4353insNN, 4354insNN,       4355insNN, 4356insNN, 4357insNN, 4358insNN, 4359insNN, 4360insNN, 4361insNN,       4362insNN, 4363insNN, 4364insNN, 4365insNN, 4366insNN, 4367insNN, 4368insNN,       4369insNN, 4370insNN, 4371insNN, 4372insNN, 4373insNN, 4374insNN, 4375insNN,       4376insNN, 4377insNN, 4378insNN, 4379insNN, 4380insNN, 4381insNN, 4382insNN,       4383insNN, 4384insNN, 4385insNN, 4386insNN, 4387insNN, 4388insNN, 4389insNN,       4390insNN, 4391insNN, 4392insNN, 4393insNN, 4394insNN, 4395insNN, 4396insNN,       4397insNN, 4398insNN, 4399insNN, 4400insNN, 4401insNN, 4402insNN, 4403insNN,       4404insNN, 4405insNN, 4406insNN, 4407insNN, 4408insNN, 4409insNN, 4410insNN,       4411insNN, 4412insNN, 4413insNN, 4414insNN, 4415insNN, 4416insNN, 4417insNN,       4418insNN, 4419insNN, 4420insNN, 4421insNN, 4422insNN, 4423insNN, 4424insNN,       4425insNN, 4426insNN, 4427insNN, 4428insNN, 4429insNN, 4430insNN, 4431insNN,       4432insNN, 4433insNN, 4434insNN, 4435insNN, 4436insNN, 4437insNN, 4438insNN,       4439insNN, 4440insNN, 4441insNN, 4442insNN, 4443insNN, 4444insNN, 4445insNN,       4446insNN, 4447insNN, 4448insNN, 4449insNN, 4450insNN, 4451insNN, 4452insNN,       4453insNN, 4454insNN, 4455insNN, 4456insNN, 4457insNN, 4458insNN, 4459insNN,       4460insNN, 4461insNN, 4462insNN, 4463insNN, 4464insNN, 4465insNN, 4466insNN,       4467insNN, 4468insNN, 4469insNN, 4470insNN, 4471insNN, 4472insNN, 4473insNN,       4474insNN, 4475insNN, 4476insNN, 4477insNN, 4478insNN, 4479insNN, 4480insNN,       4481insNN, 4482insNN, 4483insNN, 4484insNN, 4485insNN, 4486insNN, 4487insNN,       4488insNN, 4489insNN, 4490insNN, 4491insNN, 4492insNN, 4493insNN, 4494insNN,       4495insNN, 4496insNN, 4497insNN, 4498insNN, 4499insNN, 4500insNN, 4501insNN,       4502insNN, 4503insNN, 4504insNN, 4505insNN, 4506insNN, 4507insNN, 4508insNN,       4509insNN, 4510insNN, 4511insNN, 4512insNN, 4513insNN, 4514insNN, 4515insNN,       4516insNN, 4517insNN, 4518insNN, 4519insNN, 4520insNN, 4521insNN, 4522insNN,       4523insNN, 4524insNN, 4525insNN, 4526insNN, 4527insNN, 4528insNN, 4529insNN,       4530insNN, 4531insNN, 4532insNN, 4533insNN, 4534insNN, 4535insNN, 4536insNN,       4537insNN, 4538insNN, 4539insNN, 4540insNN, 4541insNN, 4542insNN, 4543insNN,       4544insNN, 4545insNN, 4546insNN, 4547insNN, 4548insNN, 4549insNN, 4550insNN,       4551insNN, 4552insNN, 4553insNN, 4554insNN, 4555insNN, 4556insNN, 4557insNN,       4558insNN, 4559insNN, 4560insNN, 4561insNN, 4562insNN, 4563insNN, 4564insNN,       4565insNN, 4566insNN, 4567insNN, 4568insNN, 4569insNN, 4570insNN, 4571insNN,       4572insNN, 4573insNN, 4574insNN, 4575insNN, 4576insNN, 4577insNN, 4578insNN,       4579insNN, 4580insNN, 4581insNN, 4582insNN, 4583insNN, 4584insNN, 4585insNN,       4586insNN, 4587insNN, 4588insNN, 4589insNN, 4590insNN, 4591insNN, 4592insNN,       4593insNN, 4594insNN, 4595insNN, 4596insNN, 4597insNN, 4598insNN, 4599insNN,       4600insNN, 4601insNN, 4602insNN, 4603insNN, 4604insNN, 4605insNN, 4606insNN,       4607insNN, 4608insNN, 4609insNN, 4610insNN, 4611insNN, 4612insNN, 4613insNN,       4614insNN, 4615insNN, 4616insNN, 4617insNN, 4618insNN, 4619insNN, 4620insNN,       4621insNN, 4622insNN, 4623insNN, 4624insNN, 4625insNN, 4626insNN, 4627insNN,       4628insNN, 4629insNN, 4630insNN, 4631insNN, 4632insNN, 4633insNN, 4634insNN,       4635insNN, 4636insNN, 4637insNN, 4638insNN, 4639insNN, 4640insNN, 4641insNN,       4642insNN, 4643insNN, 4644insNN, 4645insNN, 4646insNN, 4647insNN, 4648insNN,       4649insNN, 4650insNN, 4651insNN, 4652insNN, 4653insNN, 4654insNN, 4655insNN,       4656insNN, 4657insNN, 4658insNN, 4659insNN, 4660insNN, 4661insNN, 4662insNN,       4663insNN, 4664insNN, 4665insNN, 4666insNN, 4667insNN, 4668insNN, 4669insNN,       4670insNN, 4671insNN, 4672insNN, 4673insNN, 4674insNN, 4675insNN, 4676insNN,       4677insNN, 4678insNN, 4679insNN, 4680insNN, 4681insNN, 4682insNN, 4683insNN,       4684insNN, 4685insNN, 4686insNN, 4687insNN, 4688insNN, 4689insNN, 4690insNN,       4691insNN, 4692insNN, 4693insNN, 4694insNN, 4695insNN, 4696insNN, 4697insNN,       4698insNN, 4699insNN, 4700insNN, 4701insNN, 4702insNN, 4703insNN, 4704insNN,       4705insNN, 4706insNN, 4707insNN, 4708insNN, 4709insNN, 4710insNN, 4711insNN,       4712insNN, 4713insNN, 4714insNN, 4715insNN, 4716insNN, 4717insNN, 4718insNN,       4719insNN, 4720insNN, 4721insNN, 4722insNN, 4723insNN, 4724insNN, 4725insNN,       4726insNN, 4727insNN, 4728insNN, 4729insNN, 4730insNN, 4731insNN, 4732insNN,       4733insNN, 4734insNN, 4735insNN, 4736insNN, 4737insNN, 4738insNN, 4739insNN,       4740insNN, 4741insNN, 4742insNN, 4743insNN, 4744insNN, 4745insNN, 4746insNN,       4747insNN, 4748insNN, 4749insNN, 4750insNN, 4751insNN, 4752insNN, 4753insNN,       4754insNN, 4755insNN, 4756insNN, 4757insNN, 4758insNN, 4759insNN, 4760insNN,       4761insNN, 4762insNN, 4763insNN, 4764insNN, 4765insNN, 4766insNN, 4767insNN,       4768insNN, 4769insNN, 4770insNN, 4771insNN, 4772insNN, 4773insNN, 4774insNN,       4775insNN, 4776insNN, 4777insNN, 4778insNN, 4779insNN, 4780insNN, 4781insNN,       4782insNN, 4783insNN, 4784insNN, 4785insNN, 4786insNN, 4787insNN, 4788insNN,       4789insNN, 4790insNN, 4791insNN, 4792insNN, 4793insNN, 4794insNN, 4795insNN,       4796insNN, 4797insNN, 4798insNN, 4799insNN, 4800insNN, 4801insNN, 4802insNN,       4803insNN, 4804insNN, 4805insNN, 4806insNN, 4807insNN, 4808insNN, 4809insNN,       4810insNN, 4811insNN, 4812insNN, 4813insNN, 4814insNN, 4815insNN, 4816insNN,       4817insNN, 4818insNN, 4819insNN, 4820insNN, 4821insNN, 4822insNN, 4823insNN,       4824insNN, 4825insNN, 4826insNN, 4827insNN, 4828insNN, 4829insNN, 4830insNN,       4831insNN, 4832insNN, 4833insNN, 4834insNN, 4835insNN, 4836insNN, 4837insNN,       4838insNN, 4839insNN, 4840insNN, 4841insNN, 4842insNN, 4843insNN, 4844insNN,       4845insNN, 4846insNN, 4847insNN, 4848insNN, 4849insNN, 4850insNN, 4851insNN,       4852insNN, 4853insNN, 4854insNN, 4855insNN, 4856insNN, 4857insNN, 4858insNN,       4859insNN, 4860insNN, 4861insNN, 4862insNN, 4863insNN, 4864insNN, 4865insNN,       4866insNN, 4867insNN, 4868insNN, 4869insNN, 4870insNN, 4871insNN, 4872insNN,       4873insNN, 4874insNN, 4875insNN, 4876insNN, 4877insNN, 4878insNN, 4879insNN,       4880insNN, 4881insNN, 4882insNN, 4883insNN, 4884insNN, 4885insNN, 4886insNN,       4887insNN, 4888insNN, 4889insNN, 4890insNN, 4891insNN, 4892insNN, 4893insNN,       4894insNN, 4895insNN, 4896insNN, 4897insNN, 4898insNN, 4899insNN, 4900insNN,       4901insNN, 4902insNN, 4903insNN, 4904insNN, 4905insNN, 4906insNN, 4907insNN,       4908insNN, 4909insNN, 4910insNN, 4911insNN, 4912insNN, 4913insNN, 4914insNN,       4915insNN, 4916insNN, 4917insNN, 4918insNN, 4919insNN, 4920insNN, 4921insNN,       4922insNN, 4923insNN, 4924insNN, 4925insNN, 4926insNN, 4927insNN, 4928insNN,       4929insNN, 4930insNN, 4931insNN, 4932insNN, 4933insNN, 4934insNN, 4935insNN,       4936insNN, 4937insNN, 4938insNN, 4939insNN, 4940insNN, 4941insNN, 4942insNN,       4943insNN, 4944insNN, 4945insNN, 4946insNN, 4947insNN, 4948insNN, 4949insNN,       4950insNN, 4951insNN, 4952insNN, 4953insNN, 4954insNN, 4955insNN, 4956insNN,       4957insNN, 4958insNN, 4959insNN, 4960insNN, 4961insNN, 4962insNN, 4963insNN,       4964insNN, 4965insNN, 4966insNN, 4967insNN, 4968insNN, 4969insNN, 4970insNN,       4971insNN, 4972insNN, 4973insNN, 4974insNN, 4975insNN, 4976insNN, 4977insNN,       4978insNN, 4979insNN, 4980insNN, 4981insNN, 4982insNN, 4983insNN, 4984insNN,       4985insNN, 4986insNN, 4987insNN, 4988insNN, 4989insNN, 4990insNN, 4991insNN,       4992insNN, 4993insNN, 4994insNN, 4995insNN, 4996insNN, 4997insNN, 4998insNN,       4999insNN, 5000insNN, 5001insNN, 5002insNN, 5003insNN, 5004insNN, 5005insNN,       5006insNN, 5007insNN, 5008insNN, 5009insNN, 5010insNN, 5011insNN, 5012insNN,       5013insNN, 5014insNN, 5015insNN, 5016insNN, 5017insNN, 5018insNN, 5019insNN,       5020insNN, 5021insNN, 5022insNN, 5023insNN, 5024insNN, 5025insNN, 5026insNN,       5027insNN, 5028insNN, 5029insNN, 5030insNN, 5031insNN, 5032insNN, 5033insNN,       5034insNN, 5035insNN, 5036insNN, 5037insNN, 5038insNN, 5039insNN, 5040insNN,       5041insNN, 5042insNN, 5043insNN, 5044insNN, 5045insNN, 5046insNN, 5047insNN,       5048insNN, 5049insNN, 5050insNN, 5051insNN, 5052insNN, 5053insNN, 5054insNN,       5055insNN, 5056insNN, 5057insNN, 5058insNN, 5059insNN, 5060insNN, 5061insNN,       5062insNN, 5063insNN, 5064insNN, 5065insNN, 5066insNN, 5067insNN, 5068insNN,       5069insNN, 5070insNN, 5071insNN, 5072insNN, 5073insNN, 5074insNN, 5075insNN,       5076insNN, 5077insNN.                    
     [0231] The present invention is not to be limited in scope by the specific embodiments described herein, which are intended as single illustrations of individual aspects of the invention, and functionally equivalent methods and components are within the scope of the invention. Indeed, various modifications of the invention, in addition to those shown and described herein will become apparent to those skilled in the art from the foregoing description and accompanying drawings. Such modifications are intended to fall within the scope of the appended claims.  
     [0232] All references mentioned herein are incorporated by reference.   
    
     
       
         1 
         
           
             
10 
 
           
           
             
               5711 base pairs  
               nucleic acid  
               single  
               linear  
             
              1 

AGCTCGCTGA GACTTCCTGG ACCCCGCACC AGGCTGTGGG GTTTCTCAGA TAACTGGGCC     60 

CCTGCGCTCA GGAGGCCTTC ACCCTCTGCT CTGGGTAAAG TTCATTGGAA CAGAAAGAAA    120 

TGGATTTATC TGCTCTTCGC GTTGAAGAAG TACAAAATGT CATTAATGCT ATGCAGAAAA    180 

TCTTAGAGTG TCCCATCTGT CTGGAGTTGA TCAAGGAACC TGTCTCCACA AAGTGTGACC    240 

ACATATTTTG CAAATTTTGC ATGCTGAAAC TTCTCAACCA GAAGAAAGGG CCTTCACAGT    300 

GTCCTTTATG TAAGAATGAT ATAACCAAAA GGAGCCTACA AGAAAGTACG AGATTTAGTC    360 

AACTTGTTGA AGAGCTATTG AAAATCATTT GTGCTTTTCA GCTTGACACA GGTTTGGAGT    420 

ATGCAAACAG CTATAATTTT GCAAAAAAGG AAAATAACTC TCCTGAACAT CTAAAAGATG    480 

AAGTTTCTAT CATCCAAAGT ATGGGCTACA GAAACCGTGC CAAAAGACTT CTACAGAGTG    540 

AACCCGAAAA TCCTTCCTTG CAGGAAACCA GTCTCAGTGT CCAACTCTCT AACCTTGGAA    600 

CTGTGAGAAC TCTGAGGACA AAGCAGCGGA TACAACCTCA AAAGACGTCT GTCTACATTG    660 

AATTGGGATC TGATTCTTCT GAAGATACCG TTAATAAGGC AACTTATTGC AGTGTGGGAG    720 

ATCAAGAATT GTTACAAATC ACCCCTCAAG GAACCAGGGA TGAAATCAGT TTGGATTCTG    780 

CAAAAAAGGC TGCTTGTGAA TTTTCTGAGA CGGATGTAAC AAATACTGAA CATCATCAAC    840 

CCAGTAATAA TGATTTGAAC ACCACTGAGA AGCGTGCAGC TGAGAGGCAT CCAGAAAAGT    900 

ATCAGGGTAG TTCTGTTTCA AACTTGCATG TGGAGCCATG TGGCACAAAT ACTCATGCCA    960 

GCTCATTACA GCATGAGAAC AGCAGTTTAT TACTCACTAA AGACAGAATG AATGTAGAAA   1020 

AGGCTGAATT CTGTAATAAA AGCAAACAGC CTGGCTTAGC AAGGAGCCAA CATAACAGAT   1080 

GGGCTGGAAG TAAGGAAACA TGTAATGATA GGCGGACTCC CAGCACAGAA AAAAAGGTAG   1140 

ATCTGAATGC TGATCCCCTG TGTGAGAGAA AAGAATGGAA TAAGCAGAAA CTGCCATGCT   1200 

CAGAGAATCC TAGAGATACT GAAGATGTTC CTTGGATAAC ACTAAATAGC AGCATTCAGA   1260 

AAGTTAATGA GTGGTTTTCC AGAAGTGATG AACTGTTAGG TTCTGATGAC TCACATGATG   1320 

GGGAGTCTGA ATCAAATGCC AAAGTAGCTG ATGTATTGGA CGTTCTAAAT GAGGTAGATG   1380 

AATATTCTGG TTCTTCAGAG AAAATAGACT TACTGGCCAG TGATCCTCAT GAGGCTTTAA   1440 

TATGTAAAAG TGAAAGAGTT CACTCCAAAT CAGTAGAGAG TAATATTGAA GACAAAATAT   1500 

TTGGGAAAAC CTATCGGAAG AAGGCAAGCC TCCCCAACTT AAGCCATGTA ACTGAAAATC   1560 

TAATTATAGG AGCATTTGTT ACTGAGCCAC AGATAATACA AGAGCGTCCC CTCACAAATA   1620 

AATTAAAGCG TAAAAGGAGA CCTACATCAG GCCTTCATCC TGAGGATTTT ATCAAGAAAG   1680 

CAGATTTGGC AGTTCAAAAG ACTCCTGAAA TGATAAATCA GGGAACTAAC CAAACGGAGC   1740 

AGAATGGTCA AGTGATGAAT ATTACTAATA GTGGTCATGA GAATAAAACA AAAGGTGATT   1800 

CTATTCAGAA TGAGAAAAAT CCTAACCCAA TAGAATCACT CGAAAAAGAA TCTGCTTTCA   1860 

AAACGAAAGC TGAACCTATA AGCAGCAGTA TAAGCAATAT GGAACTCGAA TTAAATATCC   1920 

ACAATTCAAA AGCACCTAAA AAGAATAGGC TGAGGAGGAA GTCTTCTACC AGGCATATTC   1980 

ATGCGCTTGA ACTAGTAGTC AGTAGAAATC TAAGCCCACC TAATTGTACT GAATTGCAAA   2040 

TTGATAGTTG TTCTAGCAGT GAAGAGATAA AGAAAAAAAA GTACAACCAA ATGCCAGTCA   2100 

GGCACAGCAG AAACCTACAA CTCATGGAAG GTAAAGAACC TGCAACTGGA GCCAAGAAGA   2160 

GTAACAAGCC AAATGAACAG ACAAGTAAAA GACATGACAG TGATACTTTC CCAGAGCTGA   2220 

AGTTAACAAA TGCACCTGGT TCTTTTACTA AGTGTTCAAA TACCAGTGAA CTTAAAGAAT   2280 

TTGTCAATCC TAGCCTTCCA AGAGAAGAAA AAGAAGAGAA ACTAGAAACA GTTAAAGTGT   2340 

CTAATAATGC TGAAGACCCC AAAGATCTCA TGTTAAGTGG AGAAAGGGTT TTGCAAACTG   2400 

AAAGATCTGT AGAGAGTAGC AGTATTTCAC TGGTACCTGG TACTGATTAT GGCACTCAGG   2460 

AAAGTATCTC GTTACTGGAA GTTAGCACTC TAGGGAAGGC AAAAACAGAA CCAAATAAAT   2520 

GTGTGAGTCA GTGTGCAGCA TTTGAAAACC CCAAGGGACT AATTCATGGT TGTTCCAAAG   2580 

ATAATAGAAA TGACACAGAA GGCTTTAAGT ATCCATTGGG ACATGAAGTT AACCACAGTC   2640 

GGGAAACAAG CATAGAAATG GAAGAAAGTG AACTTGATGC TCAGTATTTG CAGAATACAT   2700 

TCAAGGTTTC AAAGCGCCAG TCATTTGCTC TGTTTTCAAA TCCAGGAAAT GCAGAAGAGG   2760 

AATGTGCAAC ATTCTCTGCC CACTCTGGGT CCTTAAAGAA ACAAAGTCCA AAAGTCACTT   2820 

TTGAATGTGA ACAAAAGGAA GAAAATCAAG GAAAGAATGA GTCTAATATC AAGCCTGTAC   2880 

AGACAGTTAA TATCACTGCA GGCTTTCCTG TGGTTGGTCA GAAAGATAAG CCAGTTGATA   2940 

ATGCCAAATG TAGTATCAAA GGAGGCTCTA GGTTTTGTCT ATCATCTCAG TTCAGAGGCA   3000 

ACGAAACTGG ACTCATTACT CCAAATAAAC ATGGACTTTT ACAAAACCCA TATCGTATAC   3060 

CACCACTTTT TCCCATCAAG TCATTTGTTA AAACTAAATG TAAGAAAAAT CTGCTAGAGG   3120 

AAAACTTTGA GGAACATTCA ATGTCACCTG AAAGAGAAAT GGGAAATGAG AACATTCCAA   3180 

GTACAGTGAG CACAATTAGC CGTAATAACA TTAGAGAAAA TGTTTTTAAA GGAGCCAGCT   3240 

CAAGCAATAT TAATGAAGTA GGTTCCAGTA CTAATGAAGT GGGCTCCAGT ATTAATGAAA   3300 

TAGGTTCCAG TGATGAAAAC ATTCAAGCAG AACTAGGTAG AAACAGAGGG CCAAAATTGA   3360 

ATGCTATGCT TAGATTAGGG GTTTTGCAAC CTGAGGTCTA TAAACAAAGT CTTCCTGGAA   3420 

GTAATTGTAA GCATCCTGAA ATAAAAAAGC AAGAATATGA AGAAGTAGTT CAGACTGTTA   3480 

ATACAGATTT CTCTCCATAT CTGATTTCAG ATAACTTAGA ACAGCCTATG GGAAGTAGTC   3540 

ATGCATCTCA GGTTTGTTCT GAGACACCTG ATGACCTGTT AGATGATGGT GAAATAAAGG   3600 

AAGATACTAG TTTTGCTGAA AATGACATTA AGGAAAGTTC TGCTGTTTTT AGCAAAAGCG   3660 

TCCAGAGAGG AGAGCTTAGC AGGAGTCCTA GCCCTTTCAC CCATACACAT TTGGCTCAGG   3720 

GTTACCGAAG AGGGGCCAAG AAATTAGAGT CCTCAGAAGA GAACTTATCT AGTGAGGATG   3780 

AAGAGCTTCC CTGCTTCCAA CACTTGTTAT TTGGTAAAGT AAACAATATA CCTTCTCAGT   3840 

CTACTAGGCA TAGCACCGTT GCTACCGAGT GTCTGTCTAA GAACACAGAG GAGAATTTAT   3900 

TATCATTGAA GAATAGCTTA AATGACTGCA GTAACCAGGT AATATTGGCA AAGGCATCTC   3960 

AGGAACATCA CCTTAGTGAG GAAACAAAAT GTTCTGCTAG CTTGTTTTCT TCACAGTGCA   4020 

GTGAATTGGA AGACTTGACT GCAAATACAA ACACCCAGGA TCCTTTCTTG ATTGGTTCTT   4080 

CCAAACAAAT GAGGCATCAG TCTGAAAGCC AGGGAGTTGG TCTGAGTGAC AAGGAATTGG   4140 

TTTCAGATGA TGAAGAAAGA GGAACGGGCT TGGAAGAAAA TAATCAAGAA GAGCAAAGCA   4200 

TGGATTCAAA CTTAGGTGAA GCAGCATCTG GGTGTGAGAG TGAAACAAGC GTCTCTGAAG   4260 

ACTGCTCAGG GCTATCCTCT CAGAGTGACA TTTTAACCAC TCAGCAGAGG GATACCATGC   4320 

AACATAACCT GATAAAGCTC CAGCAGGAAA TGGCTGAACT AGAAGCTGTG TTAGAACAGC   4380 

ATGGGAGCCA GCCTTCTAAC AGCTACCCTT CCATCATAAG TGACTCCTCT GCCCTTGAGG   4440 

ACCTGCGAAA TCCAGAACAA AGCACATCAG AAAAAGCAGT ATTAACTTCA CAGAAAAGTA   4500 

GTGAATACCC TATAAGCCAG AATCCAGAAG GCCTTTCTGC TGACAAGTTT GAGGTGTCTG   4560 

CAGATAGTTC TACCAGTAAA AATAAAGAAC CAGGAGTGGA AAGGTCATCC CCTTCTAAAT   4620 

GCCCATCATT AGATGATAGG TGGTACATGC ACAGTTGCTC TGGGAGTCTT CAGAATAGAA   4680 

ACTACCCATC TCAAGAGGAG CTCATTAAGG TTGTTGATGT GGAGGAGCAA CAGCTGGAAG   4740 

AGTCTGGGCC ACACGATTTG ACGGAAACAT CTTACTTGCC AAGGCAAGAT CTAGAGGGAA   4800 

CCCCTTACCT GGAATCTGGA ATCAGCCTCT TCTCTGATGA CCCTGAATCT GATCCTTCTG   4860 

AAGACAGAGC CCCAGAGTCA GCTCGTGTTG GCAACATACC ATCTTCAACC TCTGCATTGA   4920 

AAGTTCCCCA ATTGAAAGTT GCAGAATCTG CCCAGGGTCC AGCTGCTGCT CATACTACTG   4980 

ATACTGCTGG GTATAATGCA ATGGAAGAAA GTGTGAGCAG GGAGAAGCCA GAATTGACAG   5040 

CTTCAACAGA AAGGGTCAAC AAAAGAATGT CCATGGTGGT GTCTGGCCTG ACCCCAGAAG   5100 

AATTTATGCT CGTGTACAAG TTTGCCAGAA AACACCACAT CACTTTAACT AATCTAATTA   5160 

CTGAAGAGAC TACTCATGTT GTTATGAAAA CAGATGCTGA GTTTGTGTGT GAACGGACAC   5220 

TGAAATATTT TCTAGGAATT GCGGGAGGAA AATGGGTAGT TAGCTATTTC TGGGTGACCC   5280 

AGTCTATTAA AGAAAGAAAA ATGCTGAATG AGCATGATTT TGAAGTCAGA GGAGATGTGG   5340 

TCAATGGAAG AAACCACCAA GGTCCAAAGC GAGCAAGAGA ATCCCAGGAC AGAAAGATCT   5400 

TCAGGGGGCT AGAAATCTGT TGCTATGGGC CCTTCACCAA CATGCCCACA GATCAACTGG   5460 

AATGGATGGT ACAGCTGTGT GGTGCTTCTG TGGTGAAGGA GCTTTCATCA TTCACCCTTG   5520 

GCACAGGTGT CCACCCAATT GTGGTTGTGC AGCCAGATGC CTGGACAGAG GACAATGGCT   5580 

TCCATGCAAT TGGGCAGATG TGTGAGGCAC CTGTGGTGAC CCGAGAGTGG GTGTTGGACA   5640 

GTGTAGCACT CTACCAGTGC CAGGAGCTGG ACACCTACCT GATACCCCAG ATCCCCCACA   5700 

GCCACTACTG A                                                        5711 

 
           
           
             
               1863 amino acids  
               amino acid  
               single  
               linear  
             
             
               protein  
             
              2 

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
 1               5                  10                  15 

Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30 

Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45 

Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60 

Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80 

Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95 

Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110 

Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125 

Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140 

Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 

Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175 

Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190 

Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205 

Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220 

Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 

Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255 

His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270 

Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285 

Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300 

Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 

Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335 

Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350 

Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365 

Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380 

Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 

Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415 

Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430 

Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445 

Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460 

Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 

Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495 

Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510 

His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525 

Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540 

Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 

Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575 

Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590 

Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605 

Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620 

Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 

Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655 

Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670 

Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685 

Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700 

Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 

Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735 

Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750 

Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765 

Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780 

Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 

Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815 

Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830 

Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845 

Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860 

Lys Arg Gln Ser Phe Ala Leu Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 

Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895 

Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910 

Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925 

Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940 

Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 

Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975 

Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990 

Lys Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser Met 
        995                 1000                1005 

Ser Pro Glu Arg Glu Met Gly Asn Glu Asn Ile Pro Ser Thr Val Ser 
    1010                1015                1020 

Thr Ile Ser Arg Asn Asn Ile Arg Glu Asn Val Phe Lys Gly Ala Ser 
1025                1030                1035                1040 

Ser Ser Asn Ile Asn Glu Val Gly Ser Ser Thr Asn Glu Val Gly Ser 
                1045                1050                1055 

Ser Ile Asn Glu Ile Gly Ser Ser Asp Glu Asn Ile Gln Ala Glu Leu 
            1060                1065                1070 

Gly Arg Asn Arg Gly Pro Lys Leu Asn Ala Met Leu Arg Leu Gly Val 
        1075                1080                1085 

Leu Gln Pro Glu Val Tyr Lys Gln Ser Leu Pro Gly Ser Asn Cys Lys 
    1090                1095                1100 

His Pro Glu Ile Lys Lys Gln Glu Tyr Glu Glu Val Val Gln Thr Val 
1105                1110                1115                1120 

Asn Thr Asp Phe Ser Pro Tyr Leu Ile Ser Asp Asn Leu Glu Gln Pro 
                1125                1130                1135 

Met Gly Ser Ser His Ala Ser Gln Val Cys Ser Glu Thr Pro Asp Asp 
            1140                1145                1150 

Leu Leu Asp Asp Gly Glu Ile Lys Glu Asp Thr Ser Phe Ala Glu Asn 
        1155                1160                1165 

Asp Ile Lys Glu Ser Ser Ala Val Phe Ser Lys Ser Val Gln Arg Gly 
    1170                1175                1180 

Glu Leu Ser Arg Ser Pro Ser Pro Phe Thr His Thr His Leu Ala Gln 
1185                1190                1195                1200 

Gly Tyr Arg Arg Gly Ala Lys Lys Leu Glu Ser Ser Glu Glu Asn Leu 
                1205                1210                1215 

Ser Ser Glu Asp Glu Glu Leu Pro Cys Phe Gln His Leu Leu Phe Gly 
            1220                1225                1230 

Lys Val Asn Asn Ile Pro Ser Gln Ser Thr Arg His Ser Thr Val Ala 
        1235                1240                1245 

Thr Glu Cys Leu Ser Lys Asn Thr Glu Glu Asn Leu Leu Ser Leu Lys 
    1250                1255                1260 

Asn Ser Leu Asn Asp Cys Ser Asn Gln Val Ile Leu Ala Lys Ala Ser 
1265                1270                1275                1280 

Gln Glu His His Leu Ser Glu Glu Thr Lys Cys Ser Ala Ser Leu Phe 
                1285                1290                1295 

Ser Ser Gln Cys Ser Glu Leu Glu Asp Leu Thr Ala Asn Thr Asn Thr 
            1300                1305                1310 

Gln Asp Pro Phe Leu Ile Gly Ser Ser Lys Gln Met Arg His Gln Ser 
        1315                1320                1325 

Glu Ser Gln Gly Val Gly Leu Ser Asp Lys Glu Leu Val Ser Asp Asp 
    1330                1335                1340 

Glu Glu Arg Gly Thr Gly Leu Glu Glu Asn Asn Gln Glu Glu Gln Ser 
1345                1350                1355                1360 

Met Asp Ser Asn Leu Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu Thr 
                1365                1370                1375 

Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile Leu 
            1380                1385                1390 

Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu Gln 
        1395                1400                1405 

Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser Gln 
    1410                1415                1420 

Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu 
1425                1430                1435                1440 

Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Ala Val Leu Thr 
                1445                1450                1455 

Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 
            1460                1465                1470 

Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn 
        1475                1480                1485 

Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 
    1490                1495                1500 

Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 
1505                1510                1515                1520 

Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 
                1525                1530                1535 

Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr Glu Thr Ser Tyr 
            1540                1545                1550 

Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile 
        1555                1560                1565 

Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 
    1570                1575                1580 

Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu 
1585                1590                1595                1600 

Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Gly Pro Ala Ala 
                1605                1610                1615 

Ala His Thr Thr Asp Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 
            1620                1625                1630 

Ser Arg Glu Lys Pro Glu Leu Thr Ala Ser Thr Glu Arg Val Asn Lys 
        1635                1640                1645 

Arg Met Ser Met Val Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu 
    1650                1655                1660 

Val Tyr Lys Phe Ala Arg Lys His His Ile Thr Leu Thr Asn Leu Ile 
1665                1670                1675                1680 

Thr Glu Glu Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe Val 
                1685                1690                1695 

Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 
            1700                1705                1710 

Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met 
        1715                1720                1725 

Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg 
    1730                1735                1740 

Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile 
1745                1750                1755                1760 

Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro 
                1765                1770                1775 

Thr Asp Gln Leu Glu Trp Met Val Gln Leu Cys Gly Ala Ser Val Val 
            1780                1785                1790 

Lys Glu Leu Ser Ser Phe Thr Leu Gly Thr Gly Val His Pro Ile Val 
        1795                1800                1805 

Val Val Gln Pro Asp Ala Trp Thr Glu Asp Asn Gly Phe His Ala Ile 
    1810                1815                1820 

Gly Gln Met Cys Glu Ala Pro Val Val Thr Arg Glu Trp Val Leu Asp 
1825                1830                1835                1840 

Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu Asp Thr Tyr Leu Ile Pro 
                1845                1850                1855 

Gln Ile Pro His Ser His Tyr 
            1860 

 
           
           
             
               17 base pairs  
               nucleic acid  
               single  
               linear  
             
              3 

AATCTTAGAG TGTCCCA                                                    17 

 
           
           
             
               17 base pairs  
               nucleic acid  
               single  
               linear  
             
              4 

ATCTTAGTGT CCCACCT                                                    17 

 
           
           
             
               17 base pairs  
               nucleic acid  
               single  
               linear  
             
              5 

CAGAAAAAAA GGTAGAT                                                    17 

 
           
           
             
               17 base pairs  
               nucleic acid  
               single  
               linear  
             
              6 

CAGAAAAAAA AGGTAGA                                                    17 

 
           
           
             
               17 base pairs  
               nucleic acid  
               single  
               linear  
             
              7 

AGAGAATCCC AGGACAG                                                    17 

 
           
           
             
               17 base pairs  
               nucleic acid  
               single  
               linear  
             
              8 

AGAGAATCCC CAGGACA                                                    17 

 
           
           
             
               17 base pairs  
               nucleic acid  
               single  
               linear  
             
              9 

AGGACCTGCG AAATCCA                                                    17 

 
           
           
             
               17 base pairs  
               nucleic acid  
               single  
               linear  
             
              10 

AGGACCTGTG AAATCCA                                                    17