Patent Publication Number: US-2023144155-A1

Title: Syringe with biasing member

Description:
REFERENCE TO RELATED APPLICATIONS 
     This application claims the benefit of U.S. Provisional Application No. 63/278,440 filed Nov. 11, 2021, which is hereby incorporated by reference in its entirety. 
    
    
     FIELD OF THE INVENTION 
     The present disclosure generally relates to syringes, and, in particular, to syringes with biasing members. 
     BACKGROUND 
     Patients in hospitals often receive medications and medical fluids (e.g., a saline solution or a liquid medication) via a vascular access line using a syringe or an intravenous (“IV”) pump. In some applications, it may be desired to keep the vascular access line open when not in continuous use to reduce catheter occlusions and catheter infections. 
     SUMMARY 
     The disclosed subject matter relates to syringes. In certain embodiments, a syringe includes a syringe body defining a cavity and a port in fluid communication with the cavity; a movable plunger disposed within the cavity, wherein the plunger and cavity define a volume and the port is in fluid communication with the volume; and a biasing member coupled to the plunger, wherein the biasing member is configured to urge the plunger toward the port to dispense a fluid stored within the volume at a desired rate. 
     In certain embodiments, a method is disclosed and includes releasing an energized biasing member coupled to a plunger; advancing the plunger within a syringe cavity; and dispensing fluid from the syringe cavity at a desired rate for a desired period of time in response to releasing the energized biasing member. 
     In certain embodiments, a syringe includes a syringe body defining a cavity and a port in fluid communication with the cavity; a movable plunger disposed within the cavity, wherein the plunger and cavity define a volume and the port is in fluid communication with the volume; and a biasing member coupled to the plunger, wherein the biasing member is configured to advance the plunger toward the port. 
     It is understood that various configurations of the subject technology will become readily apparent to those skilled in the art from the disclosure, wherein various configurations of the subject technology are shown and described by way of illustration. As will be realized, the subject technology is capable of other and different configurations and its several details are capable of modification in various other respects, all without departing from the scope of the subject technology. Accordingly, the summary, drawings and detailed description are to be regarded as illustrative in nature and not as restrictive. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The accompanying drawings, which are included to provide further understanding and are incorporated in and constitute a part of this specification, illustrate disclosed embodiments and together with the description serve to explain the principles of the disclosed embodiments. In the drawings: 
         FIG.  1    depicts a patient receiving an infusion of a medical fluid using a syringe. 
         FIG.  2    is a cross-sectional view of a syringe assembly in accordance with various aspects of the present disclosure. 
         FIG.  3    is a cross-sectional view of a syringe assembly in an energized state, in accordance with various aspects of the present disclosure. 
         FIG.  4    is a cross-sectional view of the syringe assembly of  FIG.  3    in a released state. 
         FIG.  5    is a perspective view of a syringe assembly, in accordance with various aspects of the present disclosure. 
         FIG.  6    is a cross-sectional view of the syringe assembly of  FIG.  5   . 
         FIG.  7    is a cross-sectional view of the syringe assembly of  FIG.  5   . 
         FIG.  8    is a cross-sectional view of the syringe assembly of  FIG.  5    along section line  8 - 8 . 
         FIG.  9    is a perspective view of a syringe assembly in accordance with various aspects of the present disclosure. 
         FIG.  10    is a top view of the syringe assembly of  FIG.  9   . 
         FIG.  11    is a cross-sectional view of the syringe assembly of  FIG.  9    along section line  11 - 11 . 
         FIG.  12    is a perspective view of a syringe assembly in accordance with various aspects of the present disclosure. 
         FIG.  13    is a cross-sectional view of the syringe assembly of  FIG.  12   . 
         FIG.  14    is a cross-sectional view of the syringe assembly of  FIG.  12    along section line  14 - 14 . 
         FIG.  15    is a detail view of the syringe assembly of  FIG.  14   . 
         FIG.  16    is a perspective view of a syringe assembly in accordance with various aspects of the present disclosure. 
         FIG.  17    is a cross-sectional view of the syringe assembly of  FIG.  16   . 
     
    
    
     DETAILED DESCRIPTION 
     The detailed description set forth below is intended as a description of various configurations of the subject technology and is not intended to represent the only configurations in which the subject technology may be practiced. The detailed description includes specific details for the purpose of providing a thorough understanding of the subject technology. However, it will be apparent to those skilled in the art that the subject technology may be practiced without these specific details. In some instances, well-known structures and components are shown in block diagram form in order to avoid obscuring the concepts of the subject technology. Like components are labeled with identical element numbers for ease of understanding. Reference numbers may have letter suffixes appended to indicate separate instances of a common element while being referred to generically by the same number without a suffix letter. 
     While the following description is directed to administration of medical fluid by utilizing the disclosed syringe assemblies, it is to be understood that this description is only an example of usage and does not limit the scope of the claims. Various aspects of the disclosed syringe assemblies may be used in any application where it is desirable to administer the flow of fluid. 
       FIG.  1    depicts a patient  5  receiving an infusion of a medical fluid using a syringe assembly  100 . In the depicted example, the syringe assembly  100  can deliver a medical fluid from a syringe  102  to the patient  5 . In some embodiments, a clinician can actuate the syringe  102  to administer the medical fluid via the vascular access line  2 . 
     During a medical procedure, it may be desirable to provide a controlled amount of fluid to the patient via the vascular access line to keep a vein or vascular access line open when not in continuous use. Advantageously, keeping the vascular access line open can reduce catheter occlusions and catheter infections. In some applications, providing a continuous amount of the fluid to a patient can be therapeutic to patients that are sensitive to fluid buildup. Further, keeping the vascular access line open can increase compliance to vascular access maintenance regulations. 
     The disclosed syringe assembly can incorporate biasing members to allow for continuous flushing of the vascular access line under controlled pressure using a standalone device. By utilizing the mechanisms described herein, the syringe assembly can provide a standalone device that is portable and requires minimal attention (e.g. every 24 hours). 
     The disclosed syringe assembly overcomes several challenges discovered with respect to certain approaches to flushing the vascular access line. One challenge with manual flushing of the vascular access line is that manual flushing is time consuming and requires attention of the clinician. Further, intermittent manual flushing may still result in potential occlusions and infections. Another challenge with flushing using a dedicated pump is that a dedicated pump is costly and may be difficult to transport with the patient. Because manual flushing is time consuming, resource intensive and potentially ineffective, and a dedicated pump may be costly and difficult to transport with the patient, it is advantageous to provide a device that provides continuous flushing of the vascular access line in a compact and/or readily portable device. The disclosed syringe assembly is a self-contained assembly that allows for continuous flushing of the vascular access line at a controlled pressure. 
     Examples of syringe assemblies that allow for continuous flushing of the vascular access line without repeated manual interactions are now described. 
       FIG.  2    is a cross-sectional view of a syringe assembly  100  in accordance with various aspects of the present disclosure. In the depicted example, the syringe assembly  100  can deliver fluid to the patient. In some applications, the syringe assembly  100  can continuously deliver fluid to a patient to maintain an unoccupied fluid path in the vascular access line. Advantageously, the syringe  102  can maintain a constant and steady pressure to maintain a small amount of liquid through the patient&#39;s vein to maintain an occluded fluid path. 
     As illustrated, the syringe  102  can store a fluid to be dispensed or administered within a cavity defined by syringe body  110 . In some embodiments, the fluid is stored within a syringe volume  112  defined by the syringe body  110  and a movable plunger  120 . Fluid can be drawn into the syringe volume  112  through a port  116 . Optionally, the syringe volume  112  can be prefilled during assembly. In some embodiments, the fluid is a saline solution and/or another sterile fluid. The syringe  102  can store any suitable amount of fluid. For example, the syringe volume  112  can hold about 1 mL, 2 mL, 5 mL, 10 mL, 20 mL, 30 mL, 40 mL, 50 mL, or 60 mL. 
     In the depicted example, the plunger  120  can be moved to change or alter the syringe volume  112 . In some embodiments, the plunger  120  can move within, or relative to the syringe body  110 . The plunger  120  can be movably or resiliently sealed against the walls of the syringe body  110 . For example, the plunger  120  can be moved within the syringe body  110  to expand the syringe volume  112 . In some applications, the plunger  120  can be withdrawn or moved away from the port  116  to expand the syringe volume  112  and draw in fluid into the syringe volume  112  through the port  116 . 
     To administer or otherwise dispense the fluid within the syringe  102 , the plunger  120  can be advanced relative to the syringe body  110  to contract or reduce the syringe volume  112 . By advancing the plunger  120  or otherwise reducing the syringe volume  112 , the syringe  102  can expel fluid from the syringe volume  112  through the port  116 . As illustrated, a clinician can actuate a top portion  122  to advance or retract the plunger  120 . The top portion  122  can be coupled to the plunger  120  by a plunger shaft  124 . 
     In the depicted example, the plunger  120  can be automatically advanced relative to the syringe body  110  to allow for continuous fluid delivery through the port  116 . Advantageously, by automatically advancing the plunger  120 , a vascular access line can be kept open. In some embodiments, a biasing member  130  can be coupled to the plunger  120  to advance the plunger  120  or otherwise urge the plunger  120  toward the port  116 . Therefore, the biasing member  130  can allow for continuous fluid delivery through the port  116 . The biasing member  130  can be calibrated to apply a desired force or move at a desired velocity to provide a desired flow rate. For example, the biasing member  130  can be calibrated to provide a flow rate of 0.2 mL/hour. 
     As illustrated, the biasing member  130  can be a spring or any other suitable resilient or energy storing device. In certain applications, an open-coil helical spring can be utilized as a biasing member  130 . The biasing member  130  can be energized by moving the plunger  120  to compress the biasing member  130 . The biasing member  130  can resist the compressive force to be energized or condensed. The biasing member  130  can advance the plunger  120  when the biasing member  130  is released. 
     Optionally, the biasing member  130  can be locked or held by a locking member  131  in an energized or compressed state to prevent the inadvertent advancement of the plunger  120  and/or the administration of fluid in the syringe volume  112 . In some embodiments, the locking member  131  can prevent movement of the plunger  120 . As illustrated, the locking member  131  can be releasably attached to the plunger shaft  124  to prevent movement of the plunger  120 . In some embodiments, the locking member  131  can be attached between the top portion  122  of the plunger  120  and the upper portion  114  of the syringe body  110 . Optionally, the locking member  131  may couple directly to the biasing member  130  to retain the biasing member  130  in an energized state. The locking member  131  may have a snap fit or interference fit with components of the syringe  102 . During operation, the locking member  131  can be removed from the syringe  102  to allow the biasing member  130  to release energy and advance the plunger  120 , dispensing fluid from the syringe volume  112 . 
     As illustrated, dispensed or administered fluid from the syringe volume  112  can pass through the port  116  to the patient. The syringe  102  can be in fluid communication with the patient via tubing. In some applications, the tubing can be primed prior to connecting the tubing to the patient&#39;s vascular line and/or administering fluid to the patient. As illustrated, the tubing can be connected to the syringe  102  and the patient via luer lock  105  and luer lock  106 , respectively. 
     In some embodiments, a flow controller  104  can control the rate of fluid flow from the syringe  102  to the patient. In particular, the flow controller  104  can start, stop, and adjust the flow from the syringe  102  to the patient. In some embodiments, the flow controller  104  can prevent flow prior to priming and allow flow after the luer lock  106  is connected to the patient. Further, the flow controller  104  can adjust the flow rate of the medical fluid for fluid sensitive patients and/or to adjust the fluid pressure from the syringe  102 . 
     Advantageously, the biasing member  130  and the flow controller  104  can cooperatively generate and control the pressure and fluid flow from the syringe  102  to ensure that the fluid is administered at a constant and steady pressure through a patient&#39;s vein to maintain an unoccluded fluid path. 
       FIG.  3    is a cross-sectional view of a syringe assembly  200  in an energized state, in accordance with various aspects of the present disclosure.  FIG.  4    is a cross-sectional view of the syringe assembly  200  of  FIG.  3    in a released state. With reference to  FIGS.  3  and  4   , the syringe assembly  200  utilizes a biasing member  230  and a damper  236  to deliver fluid to the patient at a constant and steady pressure. In some embodiments, the syringe assembly  200  can utilize elements that are similar to the elements of syringe assembly  100 . Therefore, for certain elements, similar reference numerals are utilized to refer to similar elements. 
     Similar to the syringe assembly  100 , the plunger  220  can be automatically advanced relative to the syringe body  210  to allow for continuous fluid delivery through the port  216 . As illustrated, a biasing member  230  can be coupled to the plunger  220  to advance the plunger  220  or otherwise urge the plunger  220  toward the port  216 . The biasing member  230  can be calibrated to apply a desired force or move at a desired velocity to provide a desired flow rate. 
     As illustrated, the biasing member  230  can be a spring or any other suitable resilient or energy storing device. In certain applications, an open-coil helical spring can be utilized as a biasing member  230 . The biasing member  230  can be energized by moving the plunger  220  to extend or tension the biasing member  230 . The biasing member  130  can resist the extension force to be energized or tensioned. The biasing member  230  can advance the plunger  220  when the biasing member  230  is released and moves toward a relaxed, condensed state. 
     In some embodiments, the damper  236  can control the rate of fluid flow from the syringe  202 . In particular, the damper  236  can control the velocity of the plunger  220  to allow the plunger  220  to move at a desired rate. In the depicted example, the damper  236  controls the velocity of the damper piston  232 , which is coupled to the plunger  220  via a plunger shaft  224 . During operation, the flow of damper fluid through the damper  236  controls the velocity of the damper piston  232 , and therefore the plunger  220 , by exerting force on the damper piston  232 . The damper  236  can utilize any suitable fluid. For example, the damper  236  can utilize air to provide damping force. 
     In some embodiments, the damper  236  can allow for fluid to escape the damper  236  or flow around the damper piston  232  to allow the damper piston  232  to move within the damper  236 . As illustrated, the damper  236  can allow for fluid to flow through the damper channel  234  to allow the damper piston  232  to move. Optionally, the size or profile of the damper channel  234  can be modified to adjust the damping force and therefore the velocity of the damper piston  232 . 
     In some embodiments, the damper channel  234  can be varied in size to allow the damper  236  to provide a varied damper response based on the position of the damper piston  232  and/or the plunger  220 . As illustrated, an upper portion of the damper channel  234  can have a narrower profile or geometry, allowing for greater damper force and a lower portion of the damper channel  234  can have a wider profile or geometry, allowing for reduced damper force. Advantageously, by varying the geometry of the damper channel  234 , the damper  236  can provide a non-linear damper response. A non-linear damper response may be useful for use with biasing members  230  that similarly have a non-linear behavior to provide varying damper force as the biasing force changes. For example, the damper  236  may provide a greater damper force during the initial travel of the plunger  220 , when the biasing member  230  provides the greatest biasing force, and less damper force during the end of the travel of the plunger, when the biasing member  230  provides the least biasing force. Advantageously, by correlating the damping force with the biasing force, the damper  236  and the biasing member  230  can cooperatively provide a constant velocity for the damping piston  232  and the plunger  220 . 
       FIG.  5    is a perspective view of a syringe assembly  300 , in accordance with various aspects of the present disclosure.  FIG.  6    is a cross-sectional view of the syringe assembly  300  of  FIG.  5   .  FIG.  7    is a cross-sectional view of the syringe assembly  300  of  FIG.  5   .  FIG.  8    is a cross-sectional view of the syringe assembly  300  of  FIG.  5    along section line  8 - 8 . With respect to  FIGS.  5 - 8   , the syringe assembly  300  utilizes a torsional spring  330  to continuously deliver fluid to the patient. Advantageously, the use of a torsional spring  330  can allow for a compact syringe  302  profile. In some embodiments, the syringe assembly  300  can utilize elements that are similar to the elements of syringe assembly  100 . Therefore, for certain elements, similar reference numerals are utilized to refer to similar elements. 
     In the depicted example, the plunger  320  can be automatically advanced relative to the syringe body  310  to allow for continuous fluid delivery through the port  316 . Advantageously, by automatically advancing the plunger  320 , a vascular access line can be kept open. In some embodiments, the torsional spring  330  can be coupled to the plunger shaft  324  to advance the plunger  320  or otherwise urge the plunger  320  toward the port  316 . The torsional spring  330  can be calibrated to apply a desired force or move at a desired velocity to provide a desired flow rate. 
     As illustrated, the torsional spring  330  can be a coiled or wound spring. The torsional spring  330  can be energized by rotating or coiling the energized portion of the torsional spring  330   a . The energized portion of the torsional spring  330   a  can resist the rotational or torsion to be energized. The plunger  320  can be advanced by the uncoiling of the energized portion of the torsional spring  330   a . The deenergized or uncoiled portion of the torsional spring  330   b  is stored in a reduced energy state in an adjacent coil. In some embodiments, the torsional spring  330   a  can be energized by retracting the plunger  320 . 
       FIG.  9    is a perspective view of a syringe assembly  400  in accordance with various aspects of the present disclosure.  FIG.  10    is a top view of the syringe assembly  400  of  FIG.  9   .  FIG.  11    is a cross-sectional view of the syringe assembly  400  of  FIG.  9    along section line  11 - 11 . With reference to  FIGS.  9 - 11   , the syringe assembly  400  can utilize compressed gas or a chemical reaction to deliver fluid to the patient at a constant and steady pressure. Advantageously, the use of a compressed gas or chemical reaction can allow for a compact syringe  402  profile as well as a syringe  402  that does not need to be energized. In some embodiments, the syringe assembly  400  can utilize elements that are similar to the elements of syringe assembly  100 . Therefore, for certain elements, similar reference numerals are utilized to refer to similar elements. 
     In the depicted example, the plunger  420  can be automatically advanced relative to the syringe body  410  to allow for continuous fluid delivery through the port  416 . Advantageously, by automatically advancing the plunger  420 , a vascular access line can be kept open. In some embodiments, the plunger shaft  424 , and therefore the plunger  420  can be advanced by the expansion of a compressed gas or by the byproduct of a chemical reaction within a gas chamber  442 . The gas chamber  442  can be defined by the gas chamber body  444  and the movable plunger shaft  424 . As illustrated, the expansion of gasses within the gas chamber  442  can create sufficient force to advance the plunger shaft  424  and therefore the plunger  420  relative to the gas chamber body  444 . The expansion of gasses can be controlled to applied a desired force or move the plunger  420  at a desired velocity to provide a desired flow rate. 
     In some embodiments, compressed gas or chemical reactants can be stored within a capsule  440  within the gas chamber  442 . To begin fluid delivery, the capsule  440  can be pierced or punctured to advance the plunger  420 . In some embodiments, an upper end  422  of the plunger  420  includes a needle to puncture the capsule  440 . Therefore, to initiate administration of fluid, the needle may be advanced into the gas chamber  442  to puncture the capsule  440  and allow the gasses within to expand or react. Optionally, the needle can be advanced into the capsule  440  by moving or actuating the gas chamber body  444 . In some embodiments, the depth of the needle and size of the puncture can control the velocity of the plunger  420  and/or the desired flow rate of the syringe  402 . 
       FIG.  12    is a perspective view of a syringe assembly  500  in accordance with various aspects of the present disclosure.  FIG.  13    is a cross-sectional view of the syringe assembly  500  of  FIG.  12   .  FIG.  14    is a cross-sectional view of the syringe assembly  500  of  FIG.  12    along section line  14 - 14 .  FIG.  15    is a detail view of the syringe assembly  500  of  FIG.  14   . With reference to  FIGS.  12 - 15   , the syringe assembly  500  utilizes biasing members  530   a  and  530   b  and a tapered syringe body  510  to deliver fluid to the patient at a constant and steady pressure. In some embodiments, the syringe assembly  500  can utilize elements that are similar to the elements of syringe assembly  100 . Therefore, for certain elements, similar reference numerals are utilized to refer to similar elements. 
     Similar to the syringe assembly  100 , the plunger  520  can be automatically advanced relative to the syringe body  510  to allow for continuous fluid delivery through the port  516 . As illustrated, a biasing members  530   a  and  530   b  can be coupled to the plunger  520  to advance the plunger  520  or otherwise urge the plunger  520  toward the port  516 . The biasing members  530   a  and  530   b  can be calibrated to apply a desired force or move at a desired velocity to provide a desired flow rate. 
     As illustrated, the biasing members  530   a  and  530   b  can be a spring or any other suitable resilient or energy storing device. In certain applications, an open-coil helical springs can be utilized as a biasing members  530   a  and  530   b . The biasing members  530   a  and  530   b  can be disposed along the sides of the syringe body  510 . The biasing members  530   a  and  530   b  can be energized by moving the plunger  520  to extend or tension the biasing members  530   a  and  530   b . The biasing members  530   a  and  530   b  can resist the extension force to be energized or tensioned. The biasing members  530   a  and  530   b  can advance the plunger  520  when the biasing members  530   a  and  530   b  is released and moves toward a relaxed, condensed state. 
     In some embodiments, the geometry of the syringe body  510  can be utilized to control the rate of fluid flow from the syringe  502 . In particular, the diameter of the walls of the syringe body  510  can be adjusted or modified to control the velocity of the plunger  520  to allow the plunger  520  to move at a desired rate. For example, the diameter D 1  of the syringe body  510  can be selected to impart a drag force on the plunger  520  as the plunger  520  moves relative to the syringe body  510  to control the velocity of the plunger  520 . As illustrated, the geometry of the syringe body  510  can be selected to provide a drag force while still permitting motion of the plunger  520  relative to the syringe body  510 . 
     In some embodiments, the diameter of the syringe body  510  can be varied in size along various portions of the syringe body  510  to allow the plunger  520  to experience a varied drag force based on the position of the plunger  520  relative to the syringe body  510 . As illustrated, an upper portion of the syringe body  510  can have a smaller diameter D 1 , allowing for greater drag force and a lower portion of the syringe body  510  can have a larger diameter D 2  allowing for less drag force. Advantageously, by varying the geometry of the syringe body  510 , the syringe body  510  can provide a non-linear drag force profile. A non-linear drag force profile may be useful for use with biasing members  530   a  and  530   b  that similarly have a non-linear behavior to provide varying drag force as the biasing force changes. For example, the syringe body  510  may provide a greater drag force during the initial travel of the plunger  520 , when the biasing members  530   a  and  530   b  provide the greatest biasing force, and less drag force during the end of the travel of the plunger  520 , when the biasing members  530   a  and  530   b  provides the least biasing force. Advantageously, by correlating the drag force with the biasing force, the syringe body  510  and the biasing members  530   a  and  530   b  can cooperatively provide a constant velocity for the plunger  520 . 
     With reference to  FIG.  15   , in some embodiments, the port  516  can be affixed or coupled to the lower end  550  of the syringe body  510 . The port  516  may be affixed to the lower end  550  via welding, adhesive, or any other suitable attachment. 
       FIG.  16    is a perspective view of a syringe assembly  600  in accordance with various aspects of the present disclosure.  FIG.  17    is a cross-sectional view of the syringe assembly  600  of  FIG.  16   . With reference to  FIGS.  16  and  17   , the syringe assembly  500  utilizes biasing members  630   a  and  630   b  to deliver fluid to the patient at a constant and steady pressure while maintaining a compact syringe  602  profile. In some embodiments, the syringe assembly  600  can utilize elements that are similar to the elements of syringe assembly  100 . Therefore, for certain elements, similar reference numerals are utilized to refer to similar elements. 
     Similar to the syringe assembly  100 , the plunger  620  can be automatically advanced relative to the syringe body  610  to allow for continuous fluid delivery through the port  616 . As illustrated, a biasing members  630   a  and  630   b  can be coupled to the plunger  620  to advance the plunger  620  or otherwise urge the plunger  620  toward the port  616 . As illustrated, each of the biasing members  630   a  and  630   b  can be coupled to an upper end of the plunger shaft  624 . Optionally, as shown, a first end of each of the biasing members  630   a  and  630   b  can be coupled to the upper end of the plunger shaft  624  and a second end of the biasing members  630   a  and  630   b  can be coupled to a housing  636 . As shown, each of the second ends of the biasing members  630   a  and  630   b  can be spaced apart in an “arrow” arrangement. Advantageously, this arrangement allows for the biasing members  630   a  and  630   b  to be placed in a compact arrangement while allowing for sufficient force to be applied on the plunger shaft  624 . The biasing members  630   a  and  630   b  can be calibrated to apply a desired force or move at a desired velocity to provide a desired flow rate. 
     As illustrated, the biasing members  630   a  and  630   b  can be a spring or any other suitable resilient or energy storing device. In certain applications, an open-coil helical springs can be utilized as a biasing members  630   a  and  630   b . The biasing members  630   a  and  630   b  can be energized by moving the plunger  620  to extend or tension the biasing members  630   a  and  630   b . The biasing members  630   a  and  630   b  can resist the extension force to be energized or tensioned. The biasing members  630   a  and  630   b  can advance the plunger  620  when the biasing members  630   a  and  630   b  is released and moves toward a relaxed, condensed state. 
     The present disclosure is provided to enable any person skilled in the art to practice the various aspects described herein. The disclosure provides various examples of the subject technology, and the subject technology is not limited to these examples. Various modifications to these aspects will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other aspects. 
     Various examples of aspects of the disclosure are described as numbered clauses ( 1 ,  2 ,  3 , etc.) for convenience. These are provided as examples, and do not limit the subject technology. Identifications of the figures and reference numbers are provided below merely as examples and for illustrative purposes, and the clauses are not limited by those identifications. 
     Clause 1. A syringe, comprising: a syringe body defining a cavity and a port in fluid communication with the cavity; a movable plunger disposed within the cavity, wherein the plunger and cavity define a volume and the port is in fluid communication with the volume; and a biasing member coupled to the plunger, wherein the biasing member is configured to urge the plunger toward the port to dispense a fluid stored within the volume at a desired rate. 
     Clause 2. The syringe of Clause 1, wherein the biasing member comprises a spring. 
     Clause 3. The syringe of Clause 2, wherein the spring comprises a helical spring. 
     Clause 4. The syringe of Clause 2, wherein the spring comprises a torsional spring. 
     Clause 5. The syringe of Clause 1, wherein the biasing member comprises a plurality of springs. 
     Clause 6. The syringe of Clause 5, wherein a first end of each of the plurality of springs is coupled to the plunger. 
     Clause 7. The syringe of Clause 1, wherein the biasing member comprises a pressurized gas chamber. 
     Clause 8. The syringe of Clause 7, further comprising a puncturing member, wherein the puncturing member is configured to pierce the pressurized gas chamber to allow expansion of a pressurized gas. 
     Clause 9. The syringe of Clause 1, further comprising a damper coupled to the plunger, wherein the damper is configured to control a velocity of the plunger relative to the syringe body. 
     Clause 10. The syringe of Clause 9, wherein the damper comprises a damper volume and a damper channel in fluid communication with the damper volume, wherein the damper channel permits flow from the damper volume to the environment. 
     Clause 11. The syringe of Clause 10, wherein the damper channel permits a first damper flow rate at a first plunger position and a second damper flow rate at a second plunger position, wherein the second damper flow rate is greater than the first damper flow rate. 
     Clause 12. The syringe of Clause 9, wherein the damper comprises a cavity wall and the cavity wall has a first diameter that applies a first damping force at a first plunger position and a second diameter that applied a second damping force at a second plunger position, wherein the first damping force is greater than the second damping force. 
     Clause 13. The syringe of Clause 1, further comprising a flow controller in fluid communication with the port, wherein the flow controller restricts flow of the fluid at the desired rate. 
     Clause 14. The syringe of Clause 1, further comprising a locking member releasably attached to the plunger and the syringe body, wherein the locking member is configured to prevent movement of the plunger relative to the syringe body. 
     Clause 15. A method comprising: releasing an energized biasing member coupled to a plunger; advancing the plunger within a syringe cavity; and dispensing fluid from the syringe cavity at a desired rate for a desired period of time in response to releasing the energized biasing member. 
     Clause 16. The method of Clause 15, wherein the desired period of time is greater than 12 hours. 
     Clause 17. The method of Clause 15, wherein the desired rate is about 0.2 mL per hour. 
     Clause 18. The method of Clause 15, further comprising: controlling the advancing of the plunger via a damping member. 
     Clause 19. The method of Clause 15, further comprising: removing a locking member to release the energized biasing member. 
     Clause 20. A syringe, comprising: a syringe body defining a cavity and a port in fluid communication with the cavity; a movable plunger disposed within the cavity, wherein the plunger and cavity define a volume and the port is in fluid communication with the volume; and a biasing member coupled to the plunger, wherein the biasing member is configured to advance the plunger toward the port. 
     A reference to an element in the singular is not intended to mean “one and only one” unless specifically so stated, but rather “one or more.” Unless specifically stated otherwise, the term “some” refers to one or more. Pronouns in the masculine (e.g., his) include the feminine and neuter gender (e.g., her and its) and vice versa. Headings and subheadings, if any, are used for convenience only and do not limit the invention. 
     The word “exemplary” is used herein to mean “serving as an example or illustration.” Any aspect or design described herein as “exemplary” is not necessarily to be construed as preferred or advantageous over other aspects or designs. In one aspect, various alternative configurations and operations described herein may be considered to be at least equivalent. 
     A phrase such as an “aspect” does not imply that such aspect is essential to the subject technology or that such aspect applies to all configurations of the subject technology. A disclosure relating to an aspect may apply to all configurations, or one or more configurations. An aspect may provide one or more examples. A phrase such as an aspect may refer to one or more aspects and vice versa. A phrase such as an “embodiment” does not imply that such embodiment is essential to the subject technology or that such embodiment applies to all configurations of the subject technology. A disclosure relating to an embodiment may apply to all embodiments, or one or more embodiments. An embodiment may provide one or more examples. A phrase such an embodiment may refer to one or more embodiments and vice versa. A phrase such as a “configuration” does not imply that such configuration is essential to the subject technology or that such configuration applies to all configurations of the subject technology. A disclosure relating to a configuration may apply to all configurations, or one or more configurations. A configuration may provide one or more examples. A phrase such a configuration may refer to one or more configurations and vice versa. 
     In one aspect, unless otherwise stated, all measurements, values, ratings, positions, magnitudes, sizes, and other specifications that are set forth in this specification, including in the claims that follow, are approximate, not exact. In one aspect, they are intended to have a reasonable range that is consistent with the functions to which they relate and with what is customary in the art to which they pertain. 
     In one aspect, the term “coupled” or the like may refer to being directly coupled. In another aspect, the term “coupled” or the like may refer to being indirectly coupled. 
     Terms such as “top,” “bottom,” “front,” “rear” and the like if used in this disclosure should be understood as referring to an arbitrary frame of reference, rather than to the ordinary gravitational frame of reference. Thus, a top surface, a bottom surface, a front surface, and a rear surface may extend upwardly, downwardly, diagonally, or horizontally in a gravitational frame of reference. 
     Various items may be arranged differently (e.g., arranged in a different order, or partitioned in a different way) all without departing from the scope of the subject technology. All structural and functional equivalents to the elements of the various aspects described throughout this disclosure that are known or later come to be known to those of ordinary skill in the art are expressly incorporated herein by reference and are intended to be encompassed by the claims. Moreover, nothing disclosed herein is intended to be dedicated to the public regardless of whether such disclosure is explicitly recited in the claims. No claim element is to be construed under the provisions of 35 U.S.C. § 112, sixth paragraph, unless the element is expressly recited using the phrase “means for” or, in the case of a method claim, the element is recited using the phrase “step for.” Furthermore, to the extent that the term “include,” “have,” or the like is used, such term is intended to be inclusive in a manner similar to the term “comprise” as “comprise” is interpreted when employed as a transitional word in a claim. 
     The Title, Background, Summary, Brief Description of the Drawings and Abstract of the disclosure are hereby incorporated into the disclosure and are provided as illustrative examples of the disclosure, not as restrictive descriptions. It is submitted with the understanding that they will not be used to limit the scope or meaning of the claims. In addition, in the Detailed Description, it can be seen that the description provides illustrative examples and the various features are grouped together in various embodiments for the purpose of streamlining the disclosure. This method of disclosure is not to be interpreted as reflecting an intention that the claimed subject matter requires more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive subject matter lies in less than all features of a single disclosed configuration or operation. The following claims are hereby incorporated into the Detailed Description, with each claim standing on its own as a separately claimed subject matter. 
     The claims are not intended to be limited to the aspects described herein, but is to be accorded the full scope consistent with the language claims and to encompass all legal equivalents. Notwithstanding, none of the claims are intended to embrace subject matter that fails to satisfy the requirement of 35 U.S.C. § 101, 102, or 103, nor should they be interpreted in such a way.