Patent Publication Number: US-2020277572-A1

Title: Identification and isolation of human corneal endothelial cells (hcecs)

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application is a continuations of U.S. patent application Ser. No. 14/888,875, filed Nov. 3, 2015 (published as US20160102290), which is the U.S. National Stage of International Patent Application No. PCT/US2014/036616, filed May 2, 2014, which claims the benefit of U.S. Patent Application No. 61/819,146, entitled “METHOD FOR IDENTIFYING AND ISOLATING HUMAN CORNEAL ENDOTHELIAL CELLS (HCECS),” filed May 3, 2013, the contents of each of which are hereby incorporated by reference in their entireties. 
    
    
     INCORPORATION-BY-REFERENCE OF MATERIAL ELECTRONICALLY FILED 
     Incorporated by reference in its entirety herein is a computer-readable nucleotide/amino acid sequence listing submitted concurrently herewith and identified as follows: One 821,867 byte ASCII (text) file named “Seq_List” created on Aug. 13, 2018. 
     BACKGROUND OF THE INVENTION 
     When the innermost layer of the cornea, the endothelium, is damaged, for example from trauma (e.g., from cataract surgery), disease or dystrophy, the cornea swells with fluid (edema) and loses its optical clarity. Patients consequently suffer from vision loss and pain, and their only option to treat advanced disease is with corneal transplant surgery (also known as penetrating keratoplasty, PK) or Descemet&#39;s stripping endothelial keratoplasty (DSAEK), both technically difficult procedures that are very invasive to the patient and have significant limitations, such as the number of donor corneas available. 
     Recent studies have proposed the use of human corneal endothelial cells (HCECs) obtained from cadaveric donors to replace the damaged cells. See, e.g., Joyce and Zhu, Cornea. 2004 November; 23(8 Suppl):S8-S19; Engelmann, et al., Exper. Eye Res., vol. 78, no. 3, pp. 573-578, 2004. A potential advantage to such an approach could be the expansion of HCECs ex vivo before implantation into patients, thereby overcoming the limited tissue availability. HCECs can be expanded in defined tissue culture media for at least 5 passages, greatly expanding the number of cells derived from a single donor. 
     One of the main problems with such a technique is that the lack of defined surface markers specific for HCECs makes it difficult to confirm the identity of HCECs after several passages, or to select HCECs away from contaminating cells, or to identify the subset of HCECs that are likely to have the highest clinical efficacy from among the full population of HCECs, as current identification criteria are limited to cell morphology and the expression of functional genes, such as ATP1A1 (see, e.g., Kaye and Tice,  Invest Ophthalmol  1966; 522-32; Leuenberger and Novikoff,  J Cell Biol.  1974; 60721-731; McCartney et al.,  Curr Eye Res,  1987; 61479-1486) or the tight junction marker zonula occludens-1(ZO-1) (see, e.g., Petroll et al.,  Curr Eye Res.  1999 January; 18(1):10-9), neither of which are specific to HCECs. It is also difficult to isolate HCECs from contaminant fibroblasts in culture, from neighboring cells in whole corneas, or from residual corneas from DSAEK. 
     In this regard, the current isolation method for obtaining HCECs from intact corneas comprises a peel-off step, where the endothelium and its basement membrane (Descemet&#39;s membrane) are peeled off the stroma and collected. See, e.g., Ko-Hua Chen et al., “Transplantation of Adult Human Corneal Endothelium Ex Vivo: A Morphologic Study,”  Cornea  20(7): 731-737, 2001. The tissue collected thus contains HCECs, but it may also contain corneal keratocytes (specialized fibroblasts residing the stroma). Corneal keratocytes (also referred to herein simply as “keratocytes”) are undesirable contaminants in the HCECs culture, as they grow faster than the latter cells and they can take over the culture dish, thus making the final product essentially useless. In addition to residual stromal tissue, keratocytes may also arise from human endothelial cells which transform spontaneously into other types of cells such as keratocytes (see, e.g., G S. L. Peh et al., “Optimization of Human Corneal Endothelial Cells for Culture: The Removal of Corneal Stromal Fibroblast Contamination Using Magnetic Cell Separation,”  International Journal of Biomaterials , Volume 2012 (2012), Article ID 601302, 8 pages.) 
     SUMMARY OF THE INVENTION 
     Some aspects of the invention are directed to methods for the identification, enrichment and/or isolation of human corneal endothelial cells (HCECs). 
     In some embodiments, the method comprises a positive selection process in which a cell population containing human corneal cells is contacted with a positive affinity reagent that selectively binds to HCECs relative to cells other than HCECs. The cells to which the positive affinity reagent is bound are then selected, with the result being that selected cells are enriched with HCECs. In some embodiments, two or more differing positive affinity reagents which bind to HCECs but which do not bind to cells other than HCECs are employed. 
     As defined herein “cells other than human corneal endothelial cells” (or “cells other than HCECs”) include corneal keratocytes as well as HCECs of lower utility (e.g., HCECs that have undergone fibroblastic or mesenchymal transformation, etc.). 
     In other embodiments, the method comprises a negative selection process in which a cell population containing human corneal cells is contacted with a negative affinity reagent that selectively binds to cells other than HCECs (e.g., corneal keratocytes, etc.) relative to HCECs. The cells to which the negative affinity reagent is bound are then removed, with the result being that the cells that are not removed are enriched with HCECs. In some embodiments, two or more differing negative affinity reagents which bind to cells other than HCECs (e.g., corneal keratocytes, etc.) but which do not bind to HCECs are employed. 
     In some embodiments, the method comprises both (a) positive selection using one or more affinity reagents agents and (b) negative selection using one or more negative affinity reagents. 
     Other aspects of the invention are directed to affinity reagents and kits useful for the identification, enrichment and/or isolation of HCECs. 
     Still other aspects of the invention are direct to isolated and/or enriched cell populations that contain HCECs. In some embodiments, such enriched cell populations may contain affinity reagents for the purification of HCECs. 
     Further aspects of the invention a set forth in the following paragraphs: 
     Aspect 1. A method of forming a composition enriched with human corneal endothelial cells comprising: (a) contacting a cell population containing human corneal cells with a first positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells and (b) selecting cells to which the first positive affinity reagent is bound. 
     Aspect 2. The method of aspect 1, wherein the first positive affinity reagent selectively binds to human corneal endothelial cells relative to corneal keratocytes, human corneal endothelial cells of lower utility, or both. 
     Aspect 3. The method of aspect 1, wherein the first positive affinity reagent selectively binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2. 
     Aspect 4. The method of aspect 1, wherein the first positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2. 
     Aspect 5. The method of aspect 1, wherein the first positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57). 
     Aspect 6. The method of any of aspects 1-5, wherein the first positive affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix. 
     Aspect 7. The method of any of aspects 1-6, wherein the first positive affinity reagent comprises an antibody or aptamer that is coupled to a label. 
     Aspect 8. The method of aspect 7, wherein the label is selected from a magnetic label, a hapten (e.g., biotin) and a fluorescent label. 
     Aspect 9. The method of any of aspects 1-8, further comprising (a) contacting said cell population containing human corneal cells with a second positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells and (b) selecting cells to which the second positive affinity reagent is bound, wherein the second positive affinity reagent differs from the first positive affinity reagent. 
     Aspect 10. The method of aspect 9, wherein the second positive affinity reagent selectively binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2. 
     Aspect 11. The method of aspect 9, wherein the second positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2. 
     Aspect 12. The method of aspect 9, wherein the second positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57). 
     Aspect 13. The method of any of aspects 9-12, wherein the second positive affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label. 
     Aspect 14. The method of any of aspects 1-13, further comprising (a) contacting said cell population containing human corneal cells with a first negative affinity reagent that selectively binds to cells other than human corneal endothelial cells relative to human corneal endothelial cells and (b) removing the cells to which the first negative affinity reagent is bound. 
     Aspect 15. The method of aspect 14, wherein the first negative affinity reagent selectively binds to corneal keratocytes, human corneal endothelial cells of lower utility, or both, relative to human corneal endothelial cells. 
     Aspect 16. The method of aspect 14, wherein the first negative affinity reagent selectively binds to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (59) through SEQ ID NO (96) of Table 2, or wherein the first negative affinity reagent selectively binds to a corneal protein selected from protein products of genes Z1 through Z8 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes Z1 through Z8 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (97) through SEQ ID NO (109) of Table 2. 
     Aspect 17. The method of aspect 14, wherein the first negative affinity reagent comprises an antibody or aptamer that binds to a protein product of gene Y6 of Table 2. 
     Aspect 18. The method of aspect 14, wherein the first negative affinity reagent comprises an antibody or aptamer that binds to one or more of SEQ ID NO (66), SEQ ID NO (67) or SEQ ID NO (68). 
     Aspect 19. The method of any of aspects 14-18, wherein the first negative affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label. 
     Aspect 20. A composition enriched with human corneal endothelial cells that is made by the method of any of aspects 1-19. 
     Aspect 21. A kit comprising (a) a positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells and (b) a negative affinity reagent that selectively binds to cells other than human corneal endothelial cells relative to human corneal endothelial cells. 
     Aspect 22. The kit of aspect 21, wherein the positive affinity reagent selectively binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2. 
     Aspect 23. The kit of aspect 21, wherein the first positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2. 
     Aspect 24. The kit of aspect 21, wherein the first positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57). 
     Aspect 25. The kit of any of aspects 21-24, wherein the positive affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label. 
     Aspect 26. The kit of any of aspects 21-25, wherein the negative affinity reagent selectively binds to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (59) through SEQ ID NO (96) of Table 2, or wherein the negative affinity reagent selectively binds to a corneal protein selected from protein products of genes Z1 through Z8 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes Z1 through Z8 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (97) through SEQ ID NO (109) of Table 2. 
     Aspect 27. The kit of any of aspects 21-25, wherein the negative affinity reagent comprises an antibody or aptamer that binds to a protein product of gene Y6 of Table 2. 
     Aspect 28. The kit of any of aspects 21-25, wherein the first negative affinity reagent comprises an antibody or aptamer that binds to one or more of SEQ ID NO (66), SEQ ID NO (67) or SEQ ID NO (68). 
     Aspect 29. The kit of any of aspects 21-28, wherein the negative affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label. 
     Aspect 30. An affinity reagent selected from (a) a solid matrix or a label coupled to an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2, and (b) a solid matrix or a label coupled to an antibody or aptamer that binds to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (59) through SEQ ID NO (96) of Table 2, and protein products of genes Z1 through Z8 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (97) through SEQ ID NO (109) of Table 2. 
     Aspect 31. A composition enriched with human corneal endothelial cells comprising: (a) human corneal cells and (b) a first positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells. 
     Aspect 32. The composition of aspect 31, comprising human corneal endothelial cells to which the first positive affinity reagent is bound. 
     Aspect 33. The composition of any of aspects 31-32, wherein the first positive affinity reagent selectively binds to human corneal endothelial cells relative to corneal keratocytes, human corneal endothelial cells of lower utility, or both. 
     Aspect 34. The composition of any of aspects 31-33, wherein the first positive affinity reagent selectively binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2. 
     Aspect 35. The composition of any of aspects 31-33, wherein the first positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2. 
     Aspect 36. The composition of any of aspects 31-33, wherein the first positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57). 
     Aspect 37. The composition of any of aspects 31-36, wherein the first positive affinity reagent comprises an antibody or aptamer that is coupled to a label. 
     Aspect 38. The composition of aspect 37, wherein the label is selected from a magnetic label, a hapten (e.g., biotin) and a fluorescent label. 
     Aspect 39. The composition of any of aspects 31-38, further comprising a second positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells, wherein the second positive affinity reagent differs from the first positive affinity reagent. 
     Aspect 40. The composition of aspect 39, comprising human corneal endothelial cells to which the second positive affinity reagent is bound. 
     Aspect 41. The composition of any of aspects 39-40, wherein the second positive affinity reagent selectively binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, and may comprise, for example, an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2, including an antibody or aptamer that binds to one or more proteins selected from SEQ ID NO (1) through SEQ ID NO (58) of Table 2. 
     Aspect 42. The composition of any of aspects 39-40, wherein the second positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2. 
     Aspect 43. The composition of any of aspects 39-40, wherein the second positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57). 
     Aspect 44. The composition of any of aspects 39-43, wherein the second positive affinity reagent comprises a label. 
     Aspect 45. The composition of any of aspects 31-44, comprising a measurable amount of one or more negative affinity reagents that selectively binds to cells other than human corneal endothelial cells relative to human corneal endothelial cells. 
     Aspect 46. The composition of aspect 45, wherein the one or more negative affinity reagents selectively binds to corneal keratocytes, human corneal endothelial cells of lower utility, or both, relative to human corneal endothelial cells. 
     Aspect 47. The composition of any of aspects 45-46, wherein the one or more negative affinity reagents selectively bind to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2, and may comprise, for example, one or more antibodies that bind to one or more corneal proteins selected from protein products of genes Y1 through Y23 of Table 2, including one or more antibodies or aptamers that bind to one or more proteins selected from SEQ ID NO (59) through SEQ ID NO (96) of Table 2, or the one or more negative affinity reagents selectively bind to a corneal protein selected from protein products of genes Z1 through Z8 of Table 2, and may comprise, for example, one or more antibodies or aptamers that bind to one or more corneal proteins selected from protein products of genes Z1 through Z8 of Table 2, including one or more antibodies or aptamers that bind to one or more proteins selected from SEQ ID NO (97) through SEQ ID NO (109) of Table 2. 
     Aspect 48. The composition of any of aspects 45-46, wherein the one or more negative affinity reagents comprise an antibody or aptamer that binds to a protein product of gene Y6 of Table 2. 
     Aspect 49. The composition of any of aspects 45-46, wherein the one or more negative affinity reagents comprise an antibody or aptamer that binds to one or more of SEQ ID NO (66), SEQ ID NO (67) or SEQ ID NO (68). 
     Aspect 50. The composition of any of aspects 45-49, wherein the one or more negative affinity reagents comprise an antibody or aptamer that is coupled to a label. 
     These and various other aspects and embodiments and as well as various advantages of the present invention will become immediately apparent to those of ordinary skill in the art upon review of the Detailed Description and appended claims to follow. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIGS. 1A-1C  are bright field micrographs of HCECs and keratocytes in culture, with  FIG. 1A  illustrating a HCEC culture having preserved a typical cobblestone morphology (P2-HCEC-Good),  FIG. 1B  illustrating a HCEC culture having become fibroblastic (P3-HCEC-Fibroblastic), and  FIG. 1C  illustrating a human corneal keratocyte culture (P2-HCEC-Keratocytes). 
         FIG. 2  illustrates in bar graph form expression of four surface markers in different corneal cell populations analyzed by flow cytometry. 
         FIGS. 3A-3C  are dual-color fluorescence histograms of HCECs and keratocytes. These dot plots show the differential expression of two surface markers (CD56:CD166, CD56:CD90 and CD56:CAR) in each cell population, with  FIG. 3A  corresponding to the P2-HCEC-Good culture shown in  FIG. 1A ,  FIG. 3B  corresponding to the P3-HCEC-Fibroblastic culture shown in  FIG. 1B , and  FIG. 3C  corresponding to the P2-HCEC-Keratocytes culture shown in  FIG. 1C . 
         FIGS. 4A-4D  present Fluorescence profiles illustrating expression of four surface markers, specifically, CD56 ( FIG. 4A ), CAR ( FIG. 4B ), CD109 ( FIG. 4C ) and CD248 ( FIG. 4D ) in three different HCEC populations, specifically, canonical (good) HCECs, mixed (canonical and fibroblastic) HCECs, and fibroblastic (HCECs), analyzed by flow cytometry. 
         FIG. 5  illustrates in bar graph form expression of four surface markers in three different HCEC populations analyzed by flow cytometry. 
         FIGS. 6A-6C  illustrates dual-color fluorescence histograms for various pairs of surface markers, specifically, CD56:CD248 ( FIG. 6A ), CD56:CD109 ( FIG. 6B ) and CD56:CAR ( FIG. 6C ) in three different HCEC populations, specifically, canonical HCECs, mixed HCECs and fibroblastic HCECs. 
         FIG. 7  illustrates trans-endothelial electrical resistance (TEER) as a function of time for cell cultures of three different HCEC populations. 
     
    
    
     DETAILED DESCRIPTION 
     A more complete understanding of the present invention is available by reference to the following detailed description of numerous aspects and embodiments of the invention. The detailed description of the invention which follows is intended to illustrate but not limit the invention. 
     As noted above, in some aspects, the present disclosure pertains to positive selection processes in which cell populations containing human corneal cells are contacted with one or more positive affinity reagents that selectively bind to HCECs relative to cells other than HCECs (e.g., corneal keratocytes, etc.), including positive affinity reagents that selectively bind to HCECs that are likely to have a higher clinical efficacy relative to the general HCEC population 
     In other aspects, the present disclosure pertains to negative selection processes in which cell populations containing human corneal cells are contacted with one or more negative affinity reagents that bind selectively bind to cells other than HCECs (e.g., corneal keratocytes, etc.) relative to HCECs. 
     These negative and positive selection methods may be used independently or in combination with one another, for example, to identifying HCECs, to isolate HCECs and/or to enrich cell populations with HCECs, among other uses. 
     Cell populations suitable for HCEC enrichment or isolation include those obtained from intact or residual human corneas, which may come, for instance, from embryonic, fetal, pediatric or adult tissue. For example, intact corneas may be subjected to a peel-off step in which the endothelium and its basement membrane (Descemet&#39;s membrane) are peeled off the stroma and collected. See Ko-Hua Chen et al., “Transplantation of Adult Human Corneal Endothelium Ex Vivo: A Morphologic Study,”  Cornea  20(7): 731-737, 2001. In other embodiments, cell populations may be obtained from residual corneas (e.g., eye tissue remaining after a corneal button has been used for DSAEK). 
     Tissue from intact and residual corneas may be separated into individual cells by processes such as enzymatic and/or mechanical dissociation. At this step, cells are incubated for a period of time at room temperature or at 37° C. with a single enzyme or a combination of enzymes including some of the following: collagenase, papain, dispase, elastase, trypsin/EDTA, and/or DNAse. Later the tissues are mechanically dissociated using a conventional pipette or a glass pipette to obtain individual cells or cell clumps than can be then expanded in culture. See, e.g., Li W. et al.,  Invest Ophthalmol Vis Sci  2007; 48: 614; Ishino Y. et al.,  Invest Ophthalmol Vis Sci  2004; 45: 800; Chen K. H. et al.,  Cornea  2001; 20: 731. 
     The medium in which the cells may be suspended will be any medium which maintains the viability of HCECs. Various media are commercially available and may be used including Minimal Essential Medium (MEM), Dulbecco&#39;s Modified Eagle Medium (DMEM), Opti-MEMO, Media 199 or M199, Dulbecco&#39;s Modified Eagle Medium with Nutrient Mixture F-12 (DMEM/F-12), F99 Ham&#39;s F12, SHEM Ham&#39;s F12, EGM-2 endothelial growth medium frequently supplemented with serum of human or animal origin, BSA, HSA, growth factors, antioxidants, antibiotics, antimicotic agents, hormones, amino acids, and peptides. Specific examples of media are shown in Table 1 to follow. 
     
       
         
           
               
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                 Base Medium 
                 Serum 
                 Growth Factors &amp; Supplements 
               
               
                   
               
             
            
               
                 [M1] 
                 10%  
                 2 ng/ml bFGF 
               
               
                 DMEM 
                   
                 50 U/ml penicillin 
               
               
                   
                   
                 50 μg/ml streptomycin 
               
               
                 [M2] 
                 8% 
                 20 ng/ml NGF 
               
               
                 Opti-MEM-I 
                   
                 5 ng/ml EGF 
               
               
                   
                   
                 20 μg/ml ascorbic acid 
               
               
                   
                   
                 200 mg/L calcium chloride 
               
               
                   
                   
                 100 μg/ml pituitary extract 
               
               
                   
                   
                 50 μg/ml gentamicin 
               
               
                   
                   
                 1x antibiotic/antimycotic 
               
               
                   
                   
                 0.08% chondroitin sulphate 
               
               
                 [M3] 
                 5% 
                 0.5% DMSO 
               
               
                 SHEM 
                   
                 2 ng/ml EGF 
               
               
                 Ham&#39;s F12 &amp; DMEM 
                   
                 5 μg/ml insulin 
               
               
                 (1:1 ratio) 
                   
                 5 μg/ml transferrin 
               
               
                   
                   
                 5 ng/ml selenium 
               
               
                   
                   
                 0.5 μg/ml hydrocortisone 
               
               
                   
                   
                 1 nM cholera toxin 
               
               
                   
                   
                 50 μg/ml gentamicin 
               
               
                   
                   
                 1.25 μg/ml amphotericin B 
               
               
                 [M4] 
                 5% 
                 20 μg/ml ascorbic acid 
               
               
                 F99 
                   
                 20 μg/ml bovine insulin 
               
               
                 Ham&#39;s F 12 &amp; M100 
                   
                 2.5 μg/mol transferrin 
               
               
                 (1:1 ratio) 
                   
                 0.6 ng/ml sodium selentite 
               
               
                   
                   
                 10 ng/ml bFGF 
               
               
                   
               
            
           
         
       
     
     Cell cultures from intact and residual corneas contain unwanted contaminant cells which arise from residual non-endothelial tissue (e.g., stroma, epithelium, etc.) that may be present in the sample. In a culture of HCECs, HCECs that are of low cell transplant utility compared to other HCECs of high cell transplant utility may also be considered, in some fashion, “contaminants”. 
     Cell populations suitable for HCEC enrichment or isolation also include HCEC cultures in which contaminant cells have out-multiplied HCECs or in which HCECs have transformed spontaneously into other types of cells (e.g., keratocytes, etc.). As previously noted, contaminant cells such as keratocytes are particularly undesirable where it is desired to expand an HCEC culture ex vivo, because such cells grow faster than HCECs and can thus take over a cell culture. 
     Consequently, various aspects of the invention pertain to methods, reagents and kits for separation of HCECs from other cells, particularly, keratocytes and/or HCECs of lower utility. 
     The HCECs are separated from mixtures of cells by techniques that select cells having particular characteristics. 
     Human corneal endothelial cells may identified or selected (a) through positive cell markers, which are cell markers that are found on the surfaces of HCECs but which are not found on the surfaces of contaminant cells which may be intermixed with HCECs (e.g., positive selection), (b) through negative cell markers, which are cell markers that are found on surfaces of contaminant cells that are intermixed with HCECs and but which are not found on the surfaces of HCECs (e.g., negative selection), and through a combination of positive and negative cell markers. 
     For example, in the case where whole human corneas are used as a source of endothelial cells, positive cell markers may be selected from corneal proteins which are found in the endothelium (which is formed from HCECs) but which are not found in other corneal tissue (i.e., the stroma and/or the epithelium). Conversely, negative cell markers may be selected from corneal proteins which are found in corneal tissue other than endothelium tissue (i.e., the stroma and/or the epithelium) but which are not found in corneal endothelium. 
     As another example, in the case where the source of endothelial cells is an endothelium and basement membrane that have been separated from the stroma and epithelium of an intact cornea, positive cell markers may be selected from corneal cell proteins which are found in the endothelium but which are not found in the stroma, while negative cell markers may be selected from corneal cell proteins which are found in the stroma but which are not found in corneal endothelium. 
     Corneal proteins which may be useful as cell markers in conjunction with the present invention include the suitable proteins selected from those presented in the Table 2 set forth in Appendix A. 
     Positive cell markers include suitable corneal proteins selected from protein products of genes X1-X26 in Table 2 (e.g., SEQ ID NO (1) through SEQ ID NO (58)) which are present in the corneal endothelium but are not present in the stroma or the epithelium. 
     Negative cell markers include (a) suitable corneal proteins selected from protein products of genes Y1-Y23 in Table 2 (e.g., SEQ ID NO (59) through SEQ ID NO (96)), which are present in the stroma and in epithelium but are not present in the endothelium and (b) suitable corneal proteins selected from protein products of genes Z1-Z8 in Table 2 (e.g., SEQ ID NO (97) through SEQ ID NO (109)), which are present in the stroma but are not present in the corneal endothelium (or epithelium). 
     As previously noted, in some aspects, the present disclosure pertains to (a) positive selection processes in which cell populations containing human corneal cells are contacted with one, two, three, four or more positive affinity reagents that selectively bind to HCECs relative to cells other than HCECs (e.g., corneal keratocytes, etc.), (b) negative selection processes in which cell populations containing human corneal cells are contacted with one, two, three, four or more negative affinity reagents that selectively bind to cells other than HCECs (e.g., corneal keratocytes, etc.) relative to HCECs, and (c) combinations of (a) and (b). 
     For this purpose, affinity reagents are employed which preferentially bind to various corneal proteins. Positive affinity reagents are those that preferentially bind to positive cell markers associated with HCECs while negative affinity reagents are those that preferably bind to negative cell markers associated with contaminant cells other than HCECs. 
     Various positive cell markers are described above and include corneal proteins which are found in the endothelium (which is formed from HCECs) but which are not found in other corneal tissue (i.e., the stroma and/or the epithelium). Various negative cell markers are also described above and include corneal proteins which are found in corneal tissue other than endothelium (i.e., the stroma and/or the epithelium) but which are not found in corneal endothelium. 
     Those skilled in the art will recognize that suitable negative and positive affinity reagents can be employed in any order and/or in any combination. 
     Affinity reagents suitable for use in the present disclosure may comprise any species which selectively binds to a given surface marker, including positive affinity reagents which selectively bind to positive cell markers and negative affinity reagents which selectively bind to negative cell markers. 
     Especially useful affinity reagents for the practice of the invention are antibodies (also referred to herein as “affinity antibodies”), nucleic acid aptamers and other engineered forms of protein scaffolds. Antibodies include whole antibodies and antibody fragments, e.g. Fab, F(ab′)2, light or heavy chain fragments, etc. 
     Affinity antibodies selected for use will have a low level of non-specific interactions. 
     Affinity antibodies may be polyclonal or monoclonal and, where not commercially available, may be readily produced by techniques known to those skilled in the art. 
     For instance, affinity antibodies to a given corneal protein may be obtained by immunizing a xenogeneic immunocompetent mammalian host (including murine, rodentia, lagomorpha, ovine, porcine, bovine, etc.) with the corneal protein of interest. Immunizations are performed in accordance with conventional techniques, where the corneal proteins may be injected subcutaneously, intramuscularly, intraperitoneally, intravascularly, etc., over a course of one or more injections. After completion of the immunization schedule, the antiserum may be harvested in accordance with conventional methods to provide polygonal antisera specific for the corneal protein of interest. Lymphocytes may also be harvested from the appropriate lymphoid tissue, e.g. spleen, draining lymph node, etc., and fused with an appropriate fusion partner, for example, a myeloma line, producing a hybridoma secreting a specific monoclonal antibody. Screening clones of hybridomas for the antigenic specificity of interest is performed in accordance with conventional methods. 
     In numerous embodiments, affinity antibodies are coupled to a suitable substrate, for example, a label or a solid matrix. Labels include magnetic labels such as magnetic beads or micro or nanoparticles including superparamagnetic nanoparticles, which allow for ease of separation. Labels also include biotin, which binds with high affinity to avidin or streptavidin. Labels further include fluorochromes, which can be used with flow cytometry, e.g., fluorescence activated cell sorting (FACS), or the like, to allow for ease of separation of a particular cell type. Fluorescence activated cell sorters have varying degrees of sophistication, such as multiple color channels, low angle and obtuse light scattering detecting channels, impedance channels, etc. Fluorochromes include phycobiliproteins, e.g., phycoerythrin and allophycocyanins, fluorescein and Texas red, cy7 and cy5, among others. Multiple antibodies each with an affinity to a particular corneal protein may each be labeled with a different fluorochrome, to permit independent sorting (multi-color analyses) for each associated cell protein. 
     Cell selection may also be achieved by “panning” with an affinity antibody attached to a solid matrix, e.g. a plate, an immobilized bead, and so forth. For example, an affinity antibody that has specificity for a particular corneal protein may be bound to a solid matrix and corneal cells displaying that particular corneal protein can be captured by the immobilized antibody while the other cells remain in suspension and can be removed. 
     Any sorting technique may be employed which is not unduly detrimental to the viability of the selected cells. Combinations of the above techniques may be used. 
     The precise method for coupling an antibody to a given substrate (e.g., a label, solid matrix, etc.) is not critical to the practice of the present disclosure, and a number of alternatives are known in the art. For example, affinity antibodies may directly or indirectly be coupled to a substrate. Direct coupling to a substrate can be achieved by use of various chemical linking groups, as known in the art. For example, an antibody can be coupled to a substrate through side chain amino or sulfhydryl groups and heterofunctional cross-linking reagents. Many heterofunctional compounds are available for linking to various entities. Specific examples include 3-(2-pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) or 4-(N-maleimidomethyl)-cyclohexane-1-carboxylic acid N-hydroxysuccinimide ester (SMCC), which can react with a reactive sulfhydryl group on the antibody and a reactive amino group on the substrate. 
     Alternatively, affinity antibodies can be indirectly coupled to a substrate via a hapten or a secondary antibody. For instance, the antibody may be directly conjugated to a hapten, and hapten-specific binding species may be conjugated to the substrate. Suitable haptens include digoxin, digoxigenin, FITC, dinitrophenyl, nitrophenyl, avidin, streptavidin, biotin, etc. For example, an antibody may be coupled to one member of a high affinity binding system (e.g., biotin) and another member of the high affinity binding system (e.g., avidin) attached to a substrate. Methods for conjugation of a hapten to a protein are known in the art, and kits for such conjugations are commercially available. The secondary antibody may be directly or indirectly bound to the substrate. 
     During cell separation, coupled antibodies may be combined with a suspension of cells and incubated for a period of time sufficient for the antibodies to bind to proteins on the cells. The amount of antibody necessary to bind a particular cell subset may be empirically determined by performing a test separation and analysis. The cells and antibodies are incubated for a period of time sufficient for binding to occur. 
     The medium in which the cells are separated will be any medium which maintains the viability of the cells. Various media are commercially available and include those listed above. 
     Coupled affinity antibodies include coupled positive affinity antibodies specific for the corneal proteins which are present on human corneal endothelial cells and which are not present on contaminant cells such as stromal and/or epithelial cells (for positive selection) and coupled negative affinity antibodies specific for corneal proteins which are present on contaminant cells such as stromal and/or epithelial cells and which are not present on human corneal endothelial cells (negative selection). 
     Once the antibody is bound to the cell, the bound cells are separated in accordance with the specific antibody preparation. For example, FACS separation may be used with fluorochrome labeled antibodies, immunomagnetic selection may be used with magnetic-labeled antibodies, “panning” may be employed with immobilized antibodies, and so forth. 
     Cells may be separated from affinity antibodies using known techniques, as desired. As a specific example, where an antibody in an immunopanning process is a positive selection antibody, the matrix with attached endothelial cells may be washed to remove unbound cells and the endothelial cells released using a suitable technique (e.g., trypsin digest). 
     While various specific embodiments employing antibodies as affinity reagents are specifically described herein, it is to be understood that other affinity reagents for binding positive or negative cell markers can be used in the same fashion, including nucleic acid aptamers and other engineered forms of protein scaffolds. Aptamers are synthetic oligonucleotides selected from pools of random-sequence oligonucleotides which bind to a wide range of biomolecular targets with high affinity and specificity. See, e.g., J. Wang and G. Li, “Aptamers against cell surface receptors: selection, modification and application,”  Curr Med Chem.  2011; 18(27):4107-16. 
     The separated cells may be collected in any appropriate medium that maintains the viability of the cells. 
     Cell populations enriched with HCECs may thus be achieved in this manner. The HCEC population may constitute 50% or more of the cells in the cell composition, preferably at 75% or more of the cells in the cell composition, more preferably at 90% or more of the cells in the cell composition, and may be as many as 95% or more (e.g. substantially pure) of the cells in the cell population. Conversely, the cell populations may contain up to 50% of cells other than HCECs (e.g., corneal keratocytes, etc.), for instance 50% or less of such cells, preferably 25% or less of such cells, more preferably 10% or less of such cells, and may be as few as 5% or less of such cells. 
     The enriched cell population may be used immediately or stored. For example, at room temperature, at 4° C., at 37° C. or the cells may be frozen at liquid nitrogen temperatures and stored for long periods of time. 
     In certain embodiments, the enriched cells may be further expanded in vitro by adding culture media as described widely in the literature. See, e.g., Li W et al.,  Invest Ophthalmol Vis Sci  2007; 48: 614; Ishino Y et al.,  Invest Ophthalmol Vis Sci  2004; 45: 800; Chen K H et al.,  Cornea  2001; 20: 731. 
     The enriched HCEC compositions thus obtained have a variety of uses in clinical therapy, research, development, and commercial purposes. 
     For example, for therapeutic purposes, human corneal endothelial cells may be ocularly administered to an eye of a patient in order to treat corneal endothelial cell loss or dysfunction. 
     Other aspects of the invention pertain to kits for conducting cell separations as described herein. Such kits may include any combination of the following, among other elements: (a) one, two, three or more positive affinity reagents, each of which may be, for example, in the form of a positive affinity antibody attached to a suitable substrate such as a solid matrix (e.g. a plate, immobilized bead, etc.) or label (e.g., magnetic label, fluorescent label, etc.), (b) one, two, three or more unlabeled positive affinity antibodies, which the end user could label using standard methods, choosing their preferred labels (e.g., fluorophores, haptens, etc.), (c) one, two, three or more negative affinity reagents, each of which may be, for example, in the form of a negative affinity antibody attached to a suitable substrate such as a solid matrix (e.g. a plate, immobilized bead, etc.) or label (e.g., magnetic label, fluorescent label, etc.), (d) or one, two, three or more unlabeled negative affinity antibodies, which the end user could label using standard methods, choosing their preferred labels (e.g., fluorophores, haptens, etc.); (e) a combination of (a) and (c); (f) a combination of (b) and (d); (g) packaging; (h) printed materials with one or more of the following: (i) storage information and (ii) instructions regarding how to use the materials contained in the kit (e.g., positive affinity reagents, negative affinity reagents, a combination of antibodies for sequential use, etc.). 
     Example 1 
     HCECs were isolated from cadaveric donor corneas (Tampa Lions Eye Bank) and cultured and expanded following the method described by Joyce and Zhu in Cornea. 2004 November; 23(8 Suppl):S8-S19. Briefly, the endothelium and Descemet&#39;s membrane were peeled off of the stroma and after overnight stabilization at 37° C. in Opti-MEM® media (Gibco, Life Technologies Corp, Carlsbad, Calif.), supplemented with 8% fetal bovine serum (FBS), they were incubated for 1 hr at 37° C. with ethylenediaminetetraacetic acid (EDTA) to loosen up the cell-cell interactions. Cells were then mechanically dissociated to obtain a single-cell suspension, they were seeded onto FNC-coated culture wells and labeled as “P0” (passage zero). After reaching confluency, they were trypsinized and further expanded into more wells to increase their number. After one or two rounds of expansion, cells were collected and incubated with different antibodies as indicated below. Keratocytes were also obtained from cadaveric donor corneas using the method described by Stramer et al. in “Monoclonal antibody (3G5)-defined ganglioside: cell surface marker of corneal keratocytes,”  Invest. Ophthalmol. Vis. Sci.  2004 vol. 45 no. 3 807-812. While one of the HCEC cultures preserved its typical cobblestone morphology at passage 2 ( FIG. 1A ), a second culture underwent endothelial-to-mesenchymal transition during passage 3 (P3) and the cells became fibroblastic ( FIG. 1B ). Such cells are generally referred to herein as human corneal endothelial cells of lower utility (e.g., HCECs that have undergone fibroblastic or mesenchymal transformation, etc.) The keratocyte culture exhibits the typical fibroblastic, elongated cell morphology ( FIG. 1C ). 
     HCECs from each culture and keratocytes were collected and incubated with one or more of the following labelled antibodies: (a) APC-CD56 which is a mouse monoclonal antibody against a protein product of gene X15 from Table 2 (referred herein to as CD56 surface protein) coupled to allophycocyanin (BD Biosciences, #555518), (b) PE-CD166, which is a mouse monoclonal antibody against a protein product of gene X1 from Table 2 (referred here to as CD166 surface protein) coupled to phycoerythin (BD Biosciences #559263), (c) FITC-CAR, which is a mouse monoclonal antibody against a protein product of gene X25 from Table 2 (referred to as CAR surface protein) coupled to fluorescein-5-Isothiocyanate (Santa Cruz Biotechnology, Santa Cruz, Calif., USA # sc-56892) and (d) PECy7-CD90, which is a mouse monoclonal antibody against a protein product of gene Z8 from Table 2 (referred to as CD90 surface protein) coupled to a tandem conjugate of PE (energy donor) which has an excitation wavelength of 565 nm and Cy7 (energy acceptor) which has an emission wavelength of 778 nm) (BD Biosciences #561558). 
     Expression of surface markers was analyzed using a BD LSR™II flow cytometry system (BD Biosciences, San Jose, Calif.). The data shown in  FIG. 2  are representative from one experiment. Similar results were obtained upon repeated experimentation. Quantification of the % positive cells for each marker shows that in fibroblastic cultures there is a decreased expression of CD56 and CAR, indicating that antibodies to these proteins may be used in conjunction with positive affinity reagents for “good” HCECs. A significant difference in the expression of CD166 or CD90 was not detected using this particular antibody. 
       FIGS. 3A-3C  are dual-color fluorescence dot plots of the HCECs and keratocytes. These dot plots show the differential expression of two surface markers in each cell population as labeled. The percent of cells positive for an individual marker is shown in  FIG. 2 . 
     Example 2 
     HCECs were isolated from cadaveric donor corneas as described in Example 1. Also as discussed in Example 1, HCEC cultures were obtained (a) which evidenced a typical cobblestone morphology (referred to in this Example 2 as a “canonical” cell culture), (b) where all the cells had undergone an endothelial-to-mesenchymal transition (referred to in this Example as a “fibroblastic” cell culture) and (c) where some HCECs had undergone endothelial-to-mesenchymal transition (referred to in this Example as a “mixed” cell culture). 
     HCEC surface markers were identified by microarray data, and several with high expression in the endothelium (cultured and freshly dissected) but low expression in stroma were selected to be tested by flow cytometry analysis. In addition to APC-CD56, PE-CD166, FITC-CAR and PECy7-CD90 described in Example 1, also tested were (e) CD109-PE, (i.e., mouse anti-CD109), which is a monoclonal antibody against a protein product of gene Y6 from Table 2 (referred to as CD109 antigen) conjugated to phycoerythrin (PE), BD Biosciences Cat #556040 and (f) CD 248-BV, (i.e., mouse anti-Endosialin), which is an unconjugated monoclonal antibody against a protein product of gene X5 from Table 2 (referred to as CD248 antigen or Endosialin), (Millipore, Temecula, Calif., USA, Cat # MAB2626), incubated with Goat polyclonal anti-Mouse IgG secondary antibody conjugated to Brilliant Violent 421 (Biolegend, Inc., San Diego, Calif., USA, Cat #405317). 
     To address whether the expression of those markers in HCECs were affected by the fibroblastic conversion described above, HCEC cultures demonstrating two different morphologies (canonical and fibroblastic) and a corneal keratocyte culture as a control were immunostained for the surface proteins CD90, CAR, CD56 and CD166 (See Example 1,  FIG. 2 ). CD56, CAR, CD109 and CD248 expression was also compared between canonical (good), mixed, and fibroblastic HCECs (see  FIGS. 4A-4D and 5 ). Analysis of the percentage of cells expressing any of the individual markers in canonical and fibroblastic cultures demonstrated that CD56, CAR and CD248 expression was reduced in the fibroblastic culture (see  FIG. 5 ), while CD109 was elevated (see  FIG. 5 ); CD90 and CD166 expression did not significantly change between good/canonical and fibroblastic cultures (see Example 1,  FIG. 2 ). A comparable trend was observed in the keratocyte culture used as control for CD90, CAR, CD56 and CD166 expression (see Example 1,  FIG. 2 ). 
     Dot plot dual histograms of canonical, mixed and fibroblastic cultures shown in  FIGS. 6A-6C  demonstrated that canonical HCECs are predominantly CD56, CD248 and CAR positive, and CD109 negative; CD56 and CD248 expression is lost and CD109 expression increases as the culture becomes fibroblastic. 
     Finally, trans-endothelial electrical resistance (TEER) of cell cultures was measured. HCECs (a) from “good” or “canonical” cultures that expressed high levels of CD56, (b) from mixed cultures and (c) from fibroblastic cultures were plated onto inserts with 0.4 mm pores in 24-well culture plates (Transwell, Corning Costar, Acton, Mass.) at a density of 20,000 cells/insert and incubated in growth media as described in Example 1. TEER was measured using an EVOM volt-ohm meter with STX2 Electrode (World Precision Instrument, Inc., Sarasota, Fla.) for up to 65 days after initial plating. TEER measures the apical and basal plasma membrane resistance and the paracellular resistance and is used as an index of monolayer confluence integrity of tight junctions. To calculate final resistance (Ω·cm2), the resistance of blank filters were subtracted from those of filters with cells. Four wells per condition were averaged. HCECs exhibiting a canonical morphology and being CD56-positive demonstrated a superior barrier formation ability measured by TEER ( FIG. 7 ). 
     Thus, we have identified a panel of surface makers that can be used to characterize a canonical and functionally superior HCEC culture, and may be used as quality control criteria or to potentially separate the best HCEC subpopulations for expansion. 
     Although various embodiments are specifically illustrated and described herein, it will be appreciated that modifications and variations of the present invention are covered by the above teachings and are within the purview of any appended claims without departing from the spirit and intended scope of the invention. 
     Appendix A 
       
     
       
         
           
               
               
             
               
                 TABLE 2 
               
               
                   
               
             
            
               
                 Gene ID: 
                 X1 
               
               
                 Gene symbol: 
                 ALCAM 
               
               
                 Gene description: 
                 activated leukocyte cell adhesion molecule 
               
               
                 Unigene: 
                 Hs.591293 
               
               
                 Genbank: 
                 DQ486139 
               
               
                 Entrez Gene: 
                 214 
               
               
                 Refseq: 
                 NM_001627 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (1)): 
               
            
           
           
               
               
            
               
                 1 
                 meskgasscr llfcllisat vfrpglgwyt vnsaygdtii ipcrldvpqn lmfgkwkyek 
               
               
                 61 
                 pdgspvfiaf rsstkksvqy ddvpeykdrl nlsenytlsi snarisdekr fvcmlvtedn 
               
               
                 121 
                 vfeaptivkv fkqpskpeiv skalfleteq lkklgdcise dsypdgnitw yrngkvlhpl 
               
               
                 181 
                 egavviifkk emdpvtqlyt mtstleyktt kadiqmpftc svtyygpsgq ktihseqavf 
               
               
                 241 
                 diyypteqvt iqvlppknai kegdnitlkc lgngnpppee flfylpgqpe girssntytl 
               
               
                 301 
                 tdvrrnatgd ykcslidkks miastaitvh yldlslnpsg evtrqigdal pvsctisasr 
               
               
                 361 
                 natvvwmkdn irlrsspsfs slhyqdagny vcetalqeve glkkresltl ivegkpqikm 
               
               
                 421 
                 tkktdpsgls ktiichvegf pkpaiqwtit gsgsvinqte espyingryy skiiispeen 
               
               
                 481 
                 vtltctaenq lertvnslnv saisipehde adeisdenre kvndqakliv givvglllaa 
               
               
                 541 
                 lvagvvywly mkksktaskh vnkdlgnmee nkkleennhk tea 
               
               
                   
               
               
                 Gene ID: 
                 X2 
               
               
                 Gene symbol: 
                 ATP1A1 
               
               
                 Gene description: 
                 sodium/potassium-transporting ATPase subunit alpha-1 
               
               
                 Unigene: 
                 Hs.371889 
               
               
                 Genbank: 
                 BC003077 
               
               
                 Entrez Gene: 
                 476 
               
               
                 Refseq: 
                 NM_000701 | NM_001160233 | NM_001160234 
               
            
           
           
               
            
               
                 Protein sequence isoform a (SEQ ID NO (2)): 
               
            
           
           
               
               
            
               
                 1 
                 mgkgvgrdky epaayseqgd kkgkkgkkdr dmdelkkevs mddhklslde lhrkygtdls 
               
               
                 61 
                 rgltsaraae ilardgpnal tpppttpewi kfcrqlfggf smllwigail cflaysiqaa 
               
               
                 121 
                 teeepqndnl ylgvvlsavv iitgcfsyyq eaksskimes fknmvpqqal virngekmsi 
               
               
                 181 
                 naeevvvgdl vevkggdrip adlriisang ckvdnssltg esepqtrspd ftnenpletr 
               
               
                 241 
                 niaffstncv egtargivvy tgdrtvmgri atlasglegg qtpiaaeieh fihiitgvav 
               
               
                 301 
                 flgvsffils lileytwlea vifligiiva nvpegllatv tvcltltakr marknclvkn 
               
               
                 361 
                 leavetlgst sticsdktgt ltqnrmtvah mwfdnqihea dttenqsgvs fdktsatwla 
               
               
                 421 
                 lsriaglcnr avfqanqenl pilkravagd asesallkci elccgsvkem reryakivei 
               
               
                 481 
                 pfnstnkyql sihknpntse pqhllvmkga perildrcss illhgkeqpl deelkdafqn 
               
               
                 541 
                 aylelgglge rvlgfchlfl pdeqfpegfq fdtddvnfpi dnlcfvglis midppraavp 
               
               
                 601 
                 davgkcrsag ikvimvtgdh pitakaiakg vgiisegnet vediaarlni pvsqvnprda 
               
               
                 661 
                 kacvvhgsdl kdmtseqldd ilkyhteivf artspqqkli ivegcqrqga ivavtgdgvn 
               
               
                 721 
                 dspalkkadi gvamgiagsd vskqaadmil lddnfasivt gveegrlifd nlkksiaytl 
               
               
                 781 
                 tsnipeitpf lifiianipl plgtvtilci dlgtdmvpai slayeqaesd imkrqprnpk 
               
               
                 841 
                 tdklvnerli smaygqigmi qalggfftyf vilaengflp ihllglrvdw ddrwindved 
               
               
                 901 
                 sygqqwtyeq rkiveftcht affvsivvvq wadlvicktr rnsvfqqgmk nkilifglfe 
               
               
                 961 
                 etalaaflsy cpgmgvalrm yplkptwwfc afpysllify ydevrkliir rrpggwveke 
               
               
                 1021 
                 tyy 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform c (SEQ ID NO (3)): 
               
            
           
           
               
               
            
               
                 1 
                 mafkvgrdky epaayseqgd kkgkkgkkdr dmdelkkevs mddhklslde lhrkygtdls 
               
               
                 61 
                 rgltsaraae ilardgpnal tpppttpewi kfcrqlfggf smllwigail cflaysiqaa 
               
               
                 121 
                 teeepqndnl ylgvvlsavv iitgcfsyyq eaksskimes fknmvpqqal virngekmsi 
               
               
                 181 
                 naeevvvgdl vevkggdrip adlriisang ckvdnssltg esepqtrspd ftnenpletr 
               
               
                 241 
                 niaffstncv egtargivvy tgdrtvmgri atlasglegg qtpiaaeieh fihiitgvav 
               
               
                 301 
                 flgvsffils lileytwlea vifligiiva nvpegllatv tvcltltakr marknclvkn 
               
               
                 361 
                 leavetlgst sticsdktgt ltqnrmtvah mwfdnqihea dttenqsgvs fdktsatwla 
               
               
                 421 
                 lsriaglcnr avfqanqenl pilkravagd asesallkci elccgsvkem reryakivei 
               
               
                 481 
                 pfnstnkyql sihknpntse pqhllvmkga perildrcss illhgkeqpl deelkdafqn 
               
               
                 541 
                 aylelgglge rvlgfchlfl pdeqfpegfq fdtddvnfpi dnlcfvglis midppraavp 
               
               
                 601 
                 davgkcrsag ikvimvtgdh pitakaiakg vgiisegnet vediaarlni pvsqvnprda 
               
               
                 661 
                 kacvvhgsdl kdmtseqldd ilkyhteivf artspqqkli ivegcqrqga ivavtgdgvn 
               
               
                 721 
                 dspalkkadi gvamgiagsd vskqaadmil lddnfasivt gveegrlifd nlkksiaytl 
               
               
                 781 
                 tsnipeitpf lifiianipl plgtvtilci dlgtdmvpai slayeqaesd imkrqprnpk 
               
               
                 841 
                 tdklvnerli smaygqigmi qalggfftyf vilaengflp ihllglrvdw ddrwindved 
               
               
                 901 
                 sygqqwtyeq rkiveftcht affvsivvvq wadlvicktr rnsvfqqgmk nkilifglfe 
               
               
                 961 
                 etalaaflsy cpgmgvalrm yplkptwwfc afpysllify ydevrkliir rrpggwveke 
               
               
                 1021 
                 tyy 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform d (SEQ ID NO (4)): 
               
            
           
           
               
               
            
               
                 1 
                 mdelkkevsm ddhklsldel hrkygtdlsr gltsaraaei lardgpnalt pppttpewik 
               
               
                 61 
                 fcrqlfggfs mllwigailc flaysiqaat eeepqndnly lgvvlsavvi itgcfsyyqe 
               
               
                 121 
                 aksskimesf knmvpqqalv irngekmsin aeevvvgdlv evkggdripa dlriisangc 
               
               
                 181 
                 kvdnssltge sepqtrspdf tnenpletrn iaffstncve gtargivvyt gdrtvmgria 
               
               
                 241 
                 tlasgleggq tpiaaeiehf ihiitgvavf lgvsffilsl ileytwleav ifligiivan 
               
               
                 301 
                 vpegllatvt vcltltakrm arknclvknl eavetlgsts ticsdktgtl tqnrmtvahm 
               
               
                 361 
                 wfdnqihead ttenqsgvsf dktsatwlal sriaglcnra vfqangenlp ilkravagda 
               
               
                 421 
                 sesallkcie lccgsvkemr eryakiveip fnstnkyqls ihknpntsep qhllvmkgap 
               
               
                 481 
                 erildrcssi llhgkeqpld eelkdafqna ylelgglger vlgfchlflp deqfpegfqf 
               
               
                 541 
                 dtddvnfpid nlcfvglism idppraavpd avgkcrsagi kvimvtgdhp itakaiakgv 
               
               
                 601 
                 giisegnetv ediaarlnip vsqvnprdak acvvhgsdlk dmtseqlddi lkyhteivfa 
               
               
                 661 
                 rtspqqklii vegcqrqgai vavtgdgvnd spalkkadig vamgiagsdv skqaadmill 
               
               
                 721 
                 ddnfasivtg veegrlifdn lkksiaytlt snipeitpfl ifiianiplp lgtvtilcid 
               
               
                 781 
                 lgtdmvpais layeqaesdi mkrqprnpkt dklvnerlis maygqigmiq alggfftyfv 
               
               
                 841 
                 ilaengflpi hllglrvdwd drwindveds ygqqwtyeqr kiveftchta ffvsivvvqw 
               
               
                 901 
                 adlvicktrr nsvfqqgmkn kilifglfee talaaflsyc pgmgvalrmy plkptwwfca 
               
               
                 961 
                 fpysllifvy devrkliirr rpggwveket yy 
               
               
                   
               
               
                 Gene ID: 
                 X3 
               
               
                 Gene symbol: 
                 CD200 
               
               
                 Gene description: 
                 CD 200 molecule 
               
               
                 Unigene: 
                 Hs.79015 
               
               
                 Genbank: 
                 AK297194 | AF063591 | BC022522 | BC031103 | AY603771 | AK293399 
               
               
                 Entrez Gene: 
                 4345 
               
               
                 Refseq: 
                 NM_001004196 | NM_005944 
               
            
           
           
               
            
               
                 Protein sequence isoform b (SEQ ID NO (5)): 
               
            
           
           
               
               
            
               
                 1 
                 merltltrti ggplltatll gkttindyqv irmpfshlst yslvwvmaav vlctaqvqw 
               
               
                 61 
                 tqdereqlyt paslkcslqn aqealivtwq kkkayspenm vtfsenhgvv iqpaykdkin 
               
               
                 121 
                 itqlglqnst itfwnitled egcymclfnt fgfgkisgta cltvyvqpiv slhykfsedh 
               
               
                 181 
                 lnitcsatar papmvfwkvp rsgienstvt lshpngttsv tsilhikdpk nqvgkevicq 
               
               
                 241 
                 vlhlgtvtdf kqtvnkgywf svplllsivs lvillvlisi llywkrhrnq drep 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform a (SEQ ID NO (6)): 
               
            
           
           
               
               
            
               
                 1 
                 merlvirmpf shlstyslvw vmaavvlcta qvqvvtqder eqlytpaslk cslqnaqeal 
               
               
                 61 
                 ivtwqkkkav spenmvtfse nhgvviqpay kdkinitqlg lqnstitfwn itledegcym 
               
               
                 121 
                 clfnifgfgk isgtacltvy vqpivslhyk fsedhlnitc satarpapmv fwkvprsgie 
               
               
                 181 
                 nstvtlshpn gttsvtsilh ikdpknqvgk evicqvlhlg tvtdfkqtvn kgywfsvpll 
               
               
                 241 
                 lsivslvill vlisillywk rhrnqdrep 
               
               
                   
               
               
                 Gene ID: 
                 X4 
               
               
                 Gene symbol: 
                 LAMB1 
               
               
                 Gene description: 
                 laminin, beta 1 
               
               
                 Unigene: 
                 Hs.650585 
               
               
                 Genbank: 
                 M61916 
               
               
                 Entrez Gene: 
                 3912 
               
               
                 Refseq: 
                 NM__002291 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (7)): 
               
            
           
           
               
               
            
               
                 1 
                 mgllqllafs flalcrarvr aqepefsygc aegscypatg dlligraqkl svtstcglhk 
               
               
                 61 
                 pepycivshl qedkkcficn sqdpyhetln pdshlienvv ttfapnrlki wwqsengven 
               
               
                 121 
                 vtiqldleae fhfthlimtf ktfrpaamli erssdfgktw gvyryfaydc easfpgistg 
               
               
                 181 
                 pmkkvddiic dsrysdieps tegevifral dpafkiedpy spriqnllki tnlrikfvkl 
               
               
                 241 
                 htlgdnllds rmeirekyyy avydmvvrgn cfcyghasec apvdgfneev egmvhghcmc 
               
               
                 301 
                 rhntkglnce lcmdfyhdlp wrpaegrnsn ackkcncneh sischfdmav ylatgnvsgg 
               
               
                 361 
                 vcddcqhntm grnceqckpf yyqhperdir dpnfcerctc dpagsqnegi cdsytdfstg 
               
               
                 421 
                 liagqcrckl nvegehcdvc kegfydlsse dpfgckscac nplgtipggn pcdsetghcy 
               
               
                 481 
                 ckrlvtgqhc dqclpehwgl sndldgcrpc dcdlggalnn scfaesgqcs crphmigrqc 
               
               
                 541 
                 nevepgyyfa tldhylyeae eanlgpgvsi verqyiqdri pswtgagfvr vpegayleff 
               
               
                 601 
                 idnipysmey diliryepql pdhwekavit vqrpgripts srcgntipdd dnqvvslspg 
               
               
                 661 
                 sryvvlprpv cfekgtnytv rlelpqytss dsdvespytl idslvlmpyc ksldiftvgg 
               
               
                 721 
                 sgdgvvtnsa wetfqryrcl ensrsvvktp mtdvcrniif sisallhqtg lacecdpqgs 
               
               
                 781 
                 lssvcdpngg qcqcrpnvvg rtcnrcapgt fgfgpsgckp cechlqgsvn afcnpvtgqc 
               
               
                 841 
                 hcfqgvyarq cdrclpghwg fpscqpcqcn ghaddcdpvt geclncqdyt mghncercla 
               
               
                 901 
                 gyygdpiigs gdhcrpcpcp dgpdsgrqfa rscyqdpvtl qlacvcdpgy igsrcddcas 
               
               
                 961 
                 gyfgnpsevg gscqpcqchn nidttdpeac dketgrclkc lyhtegehcq fcrfgtygda 
               
               
                 1021 
                 lqqdcrkcvc nylgtvqehc ngsdcqcdka tgqclclpnv igqncdreap ntwqlasgtg 
               
               
                 1081 
                 cdpcncnaah sfgpscneft gqcqcmpgfg grtcsecqel fwgdpdvecr acdcdprgie 
               
               
                 1141 
                 tpqcdqstgq cvcvegvegp rcdkctrgys gvfpdctpch qcfalwdvii aeltnrthrf 
               
               
                 1201 
                 lekakalkis gvigpyretv dsverkvsei kdilaqspaa eplknignlf eeaeklikdv 
               
               
                 1261 
                 temmaqvevk lsdttsqsns takeldslqt eaesldntvk elaeqlefik nsdirgalds 
               
               
                 1321 
                 itkyfqmsle aeervnastt epnstveqsa lmrdrvedvm meresqfkek qeeqarllde 
               
               
                 1381 
                 lagklqsldl saaaemtcgt ppgascsete cggpncrtde gerkcggpgc gglvtvahna 
               
               
                 1441 
                 wqkamdldqd vlsalaeveq lskmvseakl radeakqsae dillktnatk ekmdksneel 
               
               
                 1501 
                 rnlikqirnf ltqdsadlds ieavanevlk mempstpqql qnltedirer veslsqvevi 
               
               
                 1561 
                 lqhsaadiar aemlleeakr asksatdvkv tadmvkeale eaekaqvaae kaikqadedi 
               
               
                 1621 
                 qgtqnlltsi esetaaseet lfnasqrise lernveelkr kaaqnsgeae yiekvvytvk 
               
               
                 1681 
                 qsaedvkktl dgeldekykk venliakkte esadarrkae mlqneaktll aqansklqll 
               
               
                 1741 
                 kdlerkyedn qryledkaqe larlegevrs llkdisqkva vystcl 
               
               
                   
               
               
                 Gene ID: 
                 X5 
               
               
                 Gene symbol: 
                 CD248 
               
               
                 Gene description: 
                 endosialin 
               
               
                 Unigene: 
                 Hs.195727 
               
               
                 Genbank: 
                 AF279142 
               
               
                 Entrez Gene: 
                 57124 
               
               
                 Refseq: 
                 NM_020404 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (8)): 
               
            
           
           
               
               
            
               
                 1 
                 mllrlllawa aagptlgqdp waaepraacg psscyalfpr rrtfleawra crelggdlat 
               
               
                 61 
                 prtpeeaqrv dslvgagpas rllwiglqrq arqcqlqrpl rgftwttgdq dtaftnwaqp 
               
               
                 121 
                 asggpcpaqr cvaleasgeh rwlegsctla vdgylcqfgf egacpalqde agqagpavyt 
               
               
                 181 
                 tpfhlvstef ewlpfgsvaa vqcqagrgas llcvkqpegg vgwsragplc lgtgcspdng 
               
               
                 241 
                 gcehecveev dghvscrcte gfrlaadgrs cedpcaqapc eqqcepggpq gyschcrlgf 
               
               
                 301 
                 rpaeddphrc vdtdecqiag vcqqmcvnyv ggfecycseg heleadgisc spagamgaqa 
               
               
                 361 
                 sqdlgdelld dgedeedede awkafnggwt empgilwmep tqppdfalay rpsfpedrep 
               
               
                 421 
                 qipypeptwp pplsaprvpy hssvlsvtrp vvvsathptl psahqppvip athpalsrdh 
               
               
                 481 
                 qipviaanyp dlpsayqpgi lsvshsaqpp ahqppmistk ypelfpahqs pmfpdtrvag 
               
               
                 541 
                 tqttthlpgi ppnhaplvtt lgaqlppqap dalvlrtqat qlpiiptaqp sltttsrspv 
               
               
                 601 
                 spahqisvpa atqpaalptl lpsqsptnqt spispthphs kapqipredg pspklalwlp 
               
               
                 661 
                 spaptaapta lgeaglaehs qrddrwllva llvptcvflv vllalgivyc trcgphapnk 
               
               
                 721 
                 ritdcyrwvi hagsksptep mpprgsltgv qtcrtsv 
               
               
                   
               
               
                 Gene ID: 
                 X6 
               
               
                 Gene symbol: 
                 COL4A6 
               
               
                 Gene description: 
                 collagen, type IV, alpha 6 
               
               
                 Unigene: 
                 Hs.145586 
               
               
                 Genbank: 
                 D21337 
               
               
                 Entrez Gene: 
                 1288 
               
               
                 Refseq: 
                 NM_033641 | NM_001847 
               
            
           
           
               
            
               
                 Protein sequence isoform b (SEQ ID NO (9)): 
               
            
           
           
               
               
            
               
                 1 
                 mhpglwlllv tlclteelaa ageksygkpc ggqdcsgscq cfpekgargr pgpigiqgpt 
               
               
                 61 
                 gpqgftgstg lsglkgergf pgllgpygpk gdkgpmgvpg flgingipgh pgqpgprgpp 
               
               
                 121 
                 gldgcngtqg avgfpgpdgy pgllgppglp gqkgskgdpv lapgsfkgmk gdpglpgldg 
               
               
                 181 
                 itgpqgapgf pgavgpagpp glqgppgppg plgpdgnmgl gfqgekgvkg dvglpgpagp 
               
               
                 241 
                 ppstgelefm gfpkgkkgsk gepgpkgfpg isgppgfpgl gttgekgekg ekgipglpgp 
               
               
                 301 
                 rgpmgsegvq gppgqqgkkg tlgfpglngf qgiegqkgdi glpgpdvfid idgavisgnp 
               
               
                 361 
                 gdpgvpglpg lkgdegiqgl rgpsgvpglp alsgvpgalg pqgfpglkgd qgnpgrttig 
               
               
                 421 
                 aaglpgrdgl pgppgppgpp spefetetlh nkesgfpglr geqgpkgnlg lkgikgdsgf 
               
               
                 481 
                 cacdggvpnt gppgepgppg pwgliglpgl kgargdrgsg gaqgpagapg lvgplgpsgp 
               
               
                 541 
                 kgkkgepils tiqgmpgdrg dsgsqgfrgv igepgkdgvp glpglpglpg dggqgfpgek 
               
               
                 601 
                 glpglpgekg hpgppglpgn glpglpgprg lpgdkgkdgl pgqqglpgsk gitlpciipg 
               
               
                 661 
                 sygpsgfpgt pgfpgpkgsr glpgtpgqpg ssgskgepgs pglvhlpelp gfpgprgekg 
               
               
                 721 
                 1pgfpglpgk dglpgmigsp glpgskgatg difgaengap geqglqgltg hkgflgdsgl 
               
               
                 781 
                 pglkgvhgkp gllgpkgerg spgtpgqvgq pgtpgssgpy gikgksglpg apgfpgisgh 
               
               
                 841 
                 pgkkgtrgkk gppgsivkkg lpglkglpgn pglvglkgsp gspgvaglpa lsgpkgekgs 
               
               
                 901 
                 vgfvgfpgip glpgipgtrg lkgipgstgk mgpsgragtp gekgdrgnpg pvgipsprrp 
               
               
                 961 
                 msnlwlkgdk gsqgsagsng fpgprgdkge agrpgppglp gapglpgiik gvsgkpgppg 
               
               
                 1021 
                 fmgirglpgl kgssgitgfp gmpgesgsqg irgspglpga sglpglkgdn gqtveisgsp 
               
               
                 1081 
                 gpkgqpgesg fkgtkgrdgl ignigfpgnk gedgkvgvsg dvglpgapgf pgvagmrgep 
               
               
                 1141 
                 glpgssghqg aigplgspgl igpkgfpgfp glhglnglpg tkgthgtpgp sitgvpgpag 
               
               
                 1201 
                 lpgpkgekgy pgigigapgk pglrgqkgdr gfpglqgpag lpgapgislp sliagqpgdp 
               
               
                 1261 
                 grpgldgerg rpgpagppgp pgpssnqgdt gdpgfpgipg pkgpkgdqgi pgfsglpgel 
               
               
                 1321 
                 glkgmrgepg fmgtpgkvgp pgdpgfpgmk gkagprgssg lqgdpgqtpt aeavqvppgp 
               
               
                 1381 
                 lglpgidgip gltgdpgaqg pvglqgskgl pgipgkdgps glpgppgalg dpglpglqgp 
               
               
                 1441 
                 pgfegapgqq gpfgmpgmpg qsmrvgytlv khsqseqvpp cpigmsqlwv gysllfvegq 
               
               
                 1501 
                 ekahnqdlgf agsclprfst mpfiycnine vchyarrndk sywlsttapi pmmpvsqtqi 
               
               
                 1561 
                 pqyisrcsvc eapsqaiavh sqditipqcp lgwrslwigy sflmhtaaga egggqslvsp 
               
               
                 1621 
                 gscledfrat pfiecsgarg tchyfankys fwlttveerq qfgelpvset lkagqlhtrv 
               
               
                 1681 
                 srcqvcmksl 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform a (SEQ ID NO (10)): 
               
            
           
           
               
               
            
               
                 1 
                 mlinklwlll vtlclteela aageksygkp cggqdcsgsc qcfpekgarg rpgpigiqgp 
               
               
                 61 
                 tgpqgftgst glsglkgerg fpgllgpygp kgdkgpmgvp gflgingipg hpgqpgprgp 
               
               
                 121 
                 pgldgcngtq gavgfpgpdg ypgllgppgl pgqkgskgdp vlapgsfkgm kgdpglpgld 
               
               
                 181 
                 gitgpqgapg fpgavgpagp pglqgppgpp gplgpdgnmg lgfqgekgvk gdvglpgpag 
               
               
                 241 
                 pppstgelef mgfpkgkkgs kgepgpkgfp gisgppgfpg lgttgekgek gekgipglpg 
               
               
                 301 
                 prgpmgsegv qgppgqqgkk gtlgfpglng fqgiegqkgd iglpgpdvfi didgavisgn 
               
               
                 361 
                 pgdpgvpglp glkgdegiqg lrgpsgvpgl palsgvpgal gpqgfpglkg dqgnpgrtti 
               
               
                 421 
                 gaaglpgrdg lpgppgppgp pspefetetl hnkesgfpgl rgeqgpkgnl glkgikgdsg 
               
               
                 481 
                 fcacdggvpn tgppgepgpp gpwgliglpg lkgargdrgs ggaqgpagap glvgplgpsg 
               
               
                 541 
                 pkgkkgepil stiqgmpgdr gdsgsqgfrg vigepgkdgv pglpglpglp gdggqgfpge 
               
               
                 601 
                 kglpglpgek ghpgppglpg nglpglpgpr glpgdkgkdg lpgqqglpgs kgitlpciip 
               
               
                 661 
                 gsygpsgfpg tpgfpgpkgs rglpgtpgqp gssgskgepg spglvhlpel pgfpgprgek 
               
               
                 721 
                 glpgfpglpg kdglpgmigs pglpgskgat gdifgaenga pgeqglqglt ghkgflgdsg 
               
               
                 781 
                 lpglkgvhgk pgllgpkger gspgtpgqvg qpgtpgssgp ygikgksglp gapgfpgisg 
               
               
                 841 
                 hpgkkgtrgk kgppgsivkk glpglkglpg npglvglkgs pgspgvaglp alsgpkgekg 
               
               
                 901 
                 svgfvgfpgi pglpgipgtr glkgipgstg kmgpsgragt pgekgdrgnp gpvgipsprr 
               
               
                 961 
                 pmsnlwlkgd kgsqgsagsn gfpgprgdkg eagrpgppgl pgapglpgii kgvsgkpgpp 
               
               
                 1021 
                 gfmgirglpg lkgssgitgf pgmpgesgsq girgspglpg asglpglkgd ngqtveisgs 
               
               
                 1081 
                 pgpkgqpges gfkgtkgrdg lignigfpgn kgedgkvgvs gdvglpgapg fpgvagmrge 
               
               
                 1141 
                 pglpgssghq gaigplgspg ligpkgfpgf pglhglnglp gtkgthgtpg psitgvpgpa 
               
               
                 1201 
                 glpgpkgekg ypgigigapg kpglrgqkgd rgfpglqgpa glpgapgisl psliagqpgd 
               
               
                 1261 
                 pgrpgldger grpgpagppg ppgpssnqgd tgdpgfpgip gpkgpkgdqg ipgfsglpge 
               
               
                 1321 
                 lglkgmrgep gfmgtpgkvg ppgdpgfpgm kgkagprgss glqgdpgqtp taeavqvppg 
               
               
                 1381 
                 plglpgidgi pgltgdpgaq gpvglqgskg lpgipgkdgp sglpgppgal gdpglpglqg 
               
               
                 1441 
                 ppgfegapgq qgpfgmpgmp gqsmrvgytl vkhsqseqvp pcpigmsqlw vgysllfveg 
               
               
                 1501 
                 qekahnqdlg fagsclprfs tmpfiycnin evchyarrnd ksywlsttap ipmmpvsqtq 
               
               
                 1561 
                 ipqyisrcsv ceapsqaiav hsqditipqc plgwrslwig ysflmhtaag aegggqslvs 
               
               
                 1621 
                 pgscledfra tpfiecsgar gtchyfanky sfwlttveer qqfgelpvse tlkagqlhtr 
               
               
                 1681 
                 vsrcqvcmks l 
               
               
                   
               
               
                 Gene ID: 
                 X7 
               
               
                 Gene symbol: 
                 PCDH7 
               
               
                 Gene description: 
                 protocadherin 7 
               
               
                 Unigene: 
                 Hs.479439 | Hs.724529 
               
               
                 Genbank: 
                 AB006755 
               
               
                 Entrez Gene: 
                 5099 
               
               
                 Refseq: 
                 NM_032456 | NM_002589 | NM_032457 | NM_001173523 
               
            
           
           
               
            
               
                 Protein sequence isoform b (SEQ ID NO (11)): 
               
            
           
           
               
               
            
               
                 1 
                 mlrmrtagwa rgwelgccll lplslslaaa kqllryrlae egpadvrign vasdlgivtg 
               
               
                 61 
                 sgevtfsles gseylkidnl tgelstserr idreklpqcq mifdenecfl dfevsvigps 
               
               
                 121 
                 qswvdlfegq vivldindnt ptfpspvltl tveenrpvgt lyllptatdr dfgrngiery 
               
               
                 181 
                 ellqepgggg sggesrraga adsapypggg gngasgggsg gskrrldase ggggtnpggr 
               
               
                 241 
                 ssvfelqvad tpdgekqpql ivkgaldreq rdsyeltlrv rdggdpprss qailrvlitd 
               
               
                 301 
                 vndnsprfek svyeadlaen sapgtpilql raadldvgvn gqieyvfgaa tesvrrllrl 
               
               
                 361 
                 detsgwlsvl hridreevnq lrftvmardr gqppktdkat vvlnikdend nvpsieirki 
               
               
                 421 
                 griplkdgva nvaedvlvdt pialvqvsdr dqgengvvtc tvvgdvpfql kpasdtegdq 
               
               
                 481 
                 nkkkyflhts tpldyeatre fnvvivavds gspslssnns livkvgdtnd nppmfgqsvv 
               
               
                 541 
                 evyfpennip gervatvlat dadsgknaei aysldssvmg ifaidpdsgd ilvntvldre 
               
               
                 601 
                 qtdryefkvn akdkgipvlq gsttvivqva dkndndpkfm qdvftfyvke nlqpnspvgm 
               
               
                 661 
                 vtvmdadkgr naemslyiee nnnifsiend tgtiystmsf drehqttytf rvkavdggdp 
               
               
                 721 
                 prsatatvsl fvmdendnap tvtlpknisy tllppssnvr tvvatvlatd sddginadln 
               
               
                 781 
                 ysivggnpfk lfeidptsgv vslvgkltqk hyglhrlvvq vndsgqpsqs tttlvhvfvn 
               
               
                 841 
                 esvsnataid sqiarslhip ltqdiagdps yeiskqrlsi vigvvagimt viliilivvm 
               
               
                 901 
                 arycrsknkn gyeagkkdhe dfftpqqhdk skkpkkdkkn kkskqplyss ivtveaskpn 
               
               
                 961 
                 gqrydsvnek lsdspsmgry rsvnggpgsp dlarhyksss plptvqlhpq sptagkkhqa 
               
               
                 1021 
                 vqdlppantf vgagdnisig sdhcseyscq tnnkyskqvr cipnifkypr eg 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform a (SEQ ID NO (12)): 
               
            
           
           
               
               
            
               
                 1 
                 mlrmrtagwa rgwelgccll lplslslaaa kqllryrlae egpadvrign vasdlgivtg 
               
               
                 61 
                 sgevtfsles gseylkidnl tgelstserr idreklpqcq mifdenecfl dfevsvigps 
               
               
                 121 
                 qsvwdlfegq vivldindnt ptfpspvltl tveenrpvgt lyllptatdr dfgrngiery 
               
               
                 181 
                 ellqepgggg sggesrraga adsapypggg gngasgggsg gskrrldase ggggtnpggr 
               
               
                 241 
                 ssvfelqvad tpdgekqpql ivkgaldreq rdsyeltlrv rdggdpprss qailrvlitd 
               
               
                 301 
                 vndnsprfek svyeadlaen sapgtpilql raadldvgvn gqieyvfgaa tesvrrllrl 
               
               
                 361 
                 detsgwlsvl hridreevnq lrftvmardr gqppktdkat vvlnikdend nvpsieirki 
               
               
                 421 
                 griplkdgva nvaedvlvdt pialvqvsdr dqgengvvtc tvvgdvpfql kpasdtegdq 
               
               
                 481 
                 nkkkyflhts tpldyeatre fnvvivavds gspslssnns livkvgdtnd nppmfgqsvv 
               
               
                 541 
                 evyfpennip gervatvlat dadsgknaei aysldssvmg ifaidpdsgd ilvntvldre 
               
               
                 601 
                 qtdryefkvn akdkgipvlq gsttvivqva dkndndpkfm qdvftfyvke nlqpnspvgm 
               
               
                 661 
                 vtvmdadkgr naemslyiee nnnifsiend tgtiystmsf drehqttytf rvkavdggdp 
               
               
                 721 
                 prsatatvsl fvmdendnap tvtlpknisy tllppssnvr tvvatvlatd sddginadln 
               
               
                 781 
                 ysivggnpfk lfeidptsgv vslvgkltqk hyglhrlvvq vndsgqpsqs tttlvhvfvn 
               
               
                 841 
                 esysnataid sqiarslhip ltqdiagdps yeiskqrlsi vigvvagimt viliilivvm 
               
               
                 901 
                 arycrsknkn gyeagkkdhe dfftpqqhdk skkpkkdkkn kkskqplyss ivtveaskpn 
               
               
                 961 
                 gqrydsvnek lsdspsmgry rsvnggpgsp dlarhyksss plptvqlhpq sptagkkhqa 
               
               
                 1021 
                 vqdlppantf vgagdnisig sdhcseyscq tnnkyskqmr lhpyitvfg 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform c (SEQ ID NO (13)): 
               
            
           
           
               
               
            
               
                 1 
                 mlrmrtagwa rgwelgccll lplslslaaa kqllryrlae egpadvrign vasdlgivtg 
               
               
                 61 
                 sgevtfsles gseylkidnl tgelstserr idreklpqcq mifdenecfl dfevsvigps 
               
               
                 121 
                 qswvdlfegq vivldindnt ptfpspvltl tveenrpvgt lyllptatdr dfgrngiery 
               
               
                 181 
                 ellqepgggg sggesrraga adsapypggg gngasgggsg gskrrldase ggggtnpggr 
               
               
                 241 
                 ssvfelqvad tpdgekqpql ivkgaldreq rdsyeltlrv rdggdpprss qailrvlitd 
               
               
                 301 
                 vndnsprfek svyeadlaen sapgtpilql raadldvgvn gqieyvfgaa tesvrrllrl 
               
               
                 361 
                 detsgwlsvl hridreevnq lrftvmardr gqppktdkat vvlnikdend nvpsieirki 
               
               
                 421 
                 griplkdgva nvaedvlvdt pialvqvsdr dqgengvvtc tvvgdvpfql kpasdtegdq 
               
               
                 481 
                 nkkkyflhts tpldyeatre fnvvivavds gspslssnns livkvgdtnd nppmfgqsvv 
               
               
                 541 
                 evyfpennip gervatvlat dadsgknaei aysldssvmg ifaidpdsgd ilvntvldre 
               
               
                 601 
                 qtdryefkvn akdkgipvlq gsttvivqva dkndndpkfm qdvftfyvke nlqpnspvgm 
               
               
                 661 
                 vtvmdadkgr naemslyiee nnnifsiend tgtiystmsf drehqttytf rvkavdggdp 
               
               
                 721 
                 prsatatvsl fvmdendnap tvtlpknisy tllppssnvr tvvatvlatd sddginadln 
               
               
                 781 
                 ysivggnpfk lfeidptsgv vslvgkltqk hyglhrlvvq vndsgqpsqs tttlvhvfvn 
               
               
                 841 
                 esvsnataid sqiarslhip ltqdiagdps yeiskqrlsi vigvvagimt viliilivvm 
               
               
                 901 
                 arycrsknkn gyeagkkdhe dfftpqqhdk skkpkkdkkn kkskqplyss ivtveaskpn 
               
               
                 961 
                 gqrydsvnek lsdspsmgry rsvnggpgsp dlarhyksss plptvqlhpq sptagkkhqa 
               
               
                 1021 
                 vqdlppantf vgagdnisig sdhcseyscq tnnkyskqpf rrvtfsvvsq pqdphqgslq 
               
               
                 1081 
                 scydsglees etpssksssg prlgalplpe dnyerttpdg svdsrplpdv altgkctrec 
               
               
                 1141 
                 deyghsdscw mpvrtsperk ksqpklstfm pvdergsqek langeaaimg drnrnllnkk 
               
               
                 1201 
                 ltssyeffsa asfskneean pedipltktg eykpspvntl trrevyl 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform d (SEQ ID NO (14)): 
               
            
           
           
               
               
            
               
                 1 
                 mlrmrtagwa rgwclgccll lplslslaaa kqllryrlae egpadvrign vasdlgivtg 
               
               
                 61 
                 sgevtfsles gseylkidni tgelstserr idreklpqcq mifdenecfl dfevsvigps 
               
               
                 121 
                 qswvdlfegq vivldindnt ptfpspvltl tveenrpvgt lyllptatdr dfgrngiery 
               
               
                 181 
                 ellqepgggg sggesrraga adsapypggg gngasgggsg gskrrldase ggggtnpggr 
               
               
                 241 
                 ssvfelqvad tpdgekqpql ivkgaldreq rdsyeltlrv rdggdpprss qailrvlitd 
               
               
                 301 
                 vndnsprfek svyeadlaen sapgtpilql raadldvgvn gqieyvfgaa tesvrrllrl 
               
               
                 361 
                 detsgwlsvl hridreevnq lrftvmardr gqppktdkat vvlnikdend nvpsieirki 
               
               
                 421 
                 griplkdgva nvaedvlvdt pialvqvsdr dqgengvvtc tvvgdvpfql kpasdtegdq 
               
               
                 481 
                 nkkkyflhts tpldyeatre fnvvivavds gspslssnns livkvgdtnd nppmfgqsvv 
               
               
                 541 
                 evyfpennip gervatvlat dadsgknaei aysldssvmg ifaidpdsgd ilvntvldre 
               
               
                 601 
                 qtdryefkvn akdkgipvlq gsttvivqva dkndndpkfm qdvftfyvke nlqpnspvgm 
               
               
                 661 
                 vtvmdadkgr naemslyiee nnnifsiend tgtiystmsf drehqttytf rvkavdggdp 
               
               
                 721 
                 prsatatvsl fvmdendnap tvtlpknisy tllppssnvr tvvatvlatd sddginadln 
               
               
                 781 
                 ysivggnpfk lfeidptsgv vslvgkltqk hyglhrlvvq vndsgqpsqs tttlvhvfvn 
               
               
                 841 
                 esvsnataid sqiarslhip ltqdiagdps yeiskqrlsi vigvvagimt viliilivvm 
               
               
                 901 
                 arycrsknkn gyeagkkdhe dfftpqqhdk skkpkkdkkn kkskqplyss ivtveaskpn 
               
               
                 961 
                 gqrydsvnek lsdspsmgry rsvnggpgsp dlarhyksss plptvqlhpq sptagkkhqa 
               
               
                 1021 
                 vqdlppantf vgagdnisig sdhcseyscq tnnkyskqpf rrylfsvvsq pqdphqgslq 
               
               
                 1081 
                 scydsglees etpssksssg prlgalplpe dnyerttpdg svgeaehmen dsrplpdval 
               
               
                 1141 
                 tgkctrecde yghsdscwmp vrtsperkks qpklstfmpv dergsqekla ngeaaimgdr 
               
               
                 1201 
                 nrnllnkklt ssyetfsaas fskneeanpe dipltktgey kpspvntltr revyl 
               
               
                   
               
               
                 Gene ID: 
                 X8 
               
               
                 Gene symbol: 
                 NOG 
               
               
                 Gene description: 
                 noggin 
               
               
                 Unigene: 
                 Hs.248201 
               
               
                 Genbank: 
                 BC034027 
               
               
                 Entrez Gene: 
                 9241 
               
               
                 Refseq: 
                 NM_005450 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO(15)): 
               
            
           
           
               
               
            
               
                 1 
                 mercpslgvt lyalvvvlgl ratpaggqhy lhirpapsdn lplvdliehp dpifdpkekd 
               
               
                 61 
                 lnetllrsll gghydpgfma tsppedrpgg gggaaggaed laeldqllrq rpsgampsei 
               
               
                 121 
                 kglefsegla qgkkqrlskk lrrklqmwlw sqtfcpvlya wndlgsrfwp ryvkvgscfs 
               
               
                 181 
                 krscsvpegm vckpsksvhl tvlrwrcqrr ggqrcgwipi qypiiseckc sc 
               
               
                   
               
               
                 Gene ID: 
                 X9 
               
               
                 Gene symbol: 
                 SULF1 
               
               
                 Gene description: 
                 sulfatase 1 
               
               
                 Unigene: 
                 Hs.409602 
               
               
                 Genbank: 
                 AF545571 
               
               
                 Entrez Gene: 
                 23213 
               
               
                 Refseq: 
                 NM_001128205 | NM_015170 | NM_001128206 | NM_001128204 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO(16)): 
               
            
           
           
               
               
            
               
                 1 
                 mkysccalvl avlgtellgs lcstvrsprf rgriqqerkn irpniilvlt ddqdvelgsl 
               
               
                 61 
                 qvmnktrkim ehggatfina fvttpmccps rssmltgkyv hnhnvytnne ncsspswqam 
               
               
                 121 
                 heprtfavyl nntgyrtaff gkylneyngs yippgwrewl gliknsrlyn ytvcrngike 
               
               
                 181 
                 khgfdyakdy ftdlitnesi nyfkmskrmy phrpvmmvis haaphgpeds apqfsklypn 
               
               
                 241 
                 asqhitpsyn yapnmdkhwi mqytgpmlpi hmeftnilqr krlqtlmsvd dsverlynml 
               
               
                 301 
                 vetgelenty iiytadhgyh igqfglvkgk smpydfdirv pffirgpsve pgsivpqivl 
               
               
                 361 
                 nidlaptild iagldtppdv dgksvlklld pekpgnrfrt nkkakiwrdt flvergkflr 
               
               
                 421 
                 kkeesskniq qsnhlpkyer vkelcqqary qtaceqpgqk wqciedtsgk lrihkckgps 
               
               
                 481 
                 dlltvrqstr nlyargfhdk dkecscresg yrasrsqrks qrqflrnqgt pkykprfvht 
               
               
                 541 
                 rqtrslsvef egeiydinle eeeelqvlqp rniakrhdeg hkgprdlqas sggnrgrmla 
               
               
                 601 
                 dssnavgppt tvrvthkcfi lpndsihcer elyqsarawk dhkayidkei ealqdkiknl 
               
               
                 661 
                 revrghlkrr kpeecscskq syynkekgvk kqeklkshlh pfkeaaqevd sklqlfkenn 
               
               
                 721 
                 rrrkkerkek rrqrkgeecs lpgltcfthd nnhwqtapfw nlgsfcacts snnntywclr 
               
               
                 781 
                 tvnethnflf cefatgfley fdmntdpyql tntvhtverg ilnqlhvqlm elrscqgykq 
               
               
                 841 
                 cnprpknldv gnkdggsydl hrgqlwdgwe g 
               
               
                   
               
               
                 Gene ID: 
                 X10 
               
               
                 Gene symbol: 
                 SORT1 
               
               
                 Gene description: 
                 sortilin 1 
               
               
                 Unigene: 
                 Hs.485195 
               
               
                 Genbank: 
                 X98248 
               
               
                 Entrez Gene: 
                 6272 
               
               
                 Refseq: 
                 NM_002959 | NM_001205228 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (17)): 
               
            
           
           
               
               
            
               
                 1 
                 merpwgaadg lsrwphglgl llllqllpps tlsqdrldap pppaaplprw sgpigvswgl 
               
               
                 61 
                 raaaaggafp rggrwrrsap gedeecgrvr dfvaklannt hqhvfddlrg syslswvgds 
               
               
                 121 
                 tgvilvlttf hvplvimtfg qsklyrsedy gknfkditdl inntfirtef gmaigpensg 
               
               
                 181 
                 kvvltaevsg gsrggrifts sdfaknfvqt dlpfhpltqm myspqnsdyl lalstenglw 
               
               
                 241 
                 vsknfggkwe eihkavclak wgsdntifft tyangsckad lgalelwrts dlgksfktig 
               
               
                 301 
                 vkiysfglgg rflfasvmad kdttrrihvs tdqgdtwsma qlpsvgqeqf ysilaanddm 
               
               
                 361 
                 vfmhvdepgd tgfgtiftsd drgivysksl drhlytttgg etdftnvtsl rgvyitsvls 
               
               
                 421 
                 ednsiqtmit fdqggrwthl rkpensecda taknknecsl hihasysisq klnvpmapls 
               
               
                 481 
                 epnavgivia hgsvgdaisv mvpdvyisdd ggyswtkmle gphyytilds ggiivaiehs 
               
               
                 541 
                 srpinvikfs tdegqcwqty tftrdpiyft glasepgars mnisiwgfte sfltsqwvsy 
               
               
                 601 
                 tidfkdiler nceekdytiw lahstdpedy edgcilgyke qflrlrkssv cqngrdyvvt 
               
               
                 661 
                 kqpsicicsl edflcdfgyy rpendskcve qpelkghdle fclygreehl ttngyrkipg 
               
               
                 721 
                 dkcqggvnpv revkdlkkkc tsnflspekq nsksnsvpii laivglmlvt vvagvlivkk 
               
               
                 781 
                 yvcggrflvh rysvlqqhae angvdgvdal dtashtnksg yhddsdedll e 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (18)): 
               
            
           
           
               
               
            
               
                 1 
                 mtfgqsklyr sedygknfkd itdlinntfi rtefgmaigp ensgkvvlta evsggsrggr 
               
               
                 61 
                 ifrssdfakn fvqtdlpfhp ltqmmyspqn sdyllalste nglwvsknfg gkweeihkav 
               
               
                 121 
                 clakwgsdnt iffttyangs ctdlgalelw rtsdlgksfk tigvkiysfg lggrflfasv 
               
               
                 181 
                 madkdttrri hvstdqgdtw smaqlpsvgq eqfysilaan ddmvfmhvde pgdtgfgtif 
               
               
                 241 
                 tsddrgivys ksldrhlytt tggetdftnv tslrgvyits vlsednsiqt mitfdqggrw 
               
               
                 301 
                 thlrkpense cdataknkne cslhihasys isqklnvpma plsepnavgi viahgsvgda 
               
               
                 361 
                 isvmvpdvyi sddggyswtk mlegphyyti ldsggiivai ehssrpinvi kfstdegqcw 
               
               
                 421 
                 qtytftrdpi yftglasepg arsmnisiwg ftesfltsqw vsytidfkdi lernceekdy 
               
               
                 481 
                 tiwlahstdp edyedgcilg ykeqflrlrk ssvcqngrdy vvtkqpsicl csledflcdf 
               
               
                 541 
                 gyyrpendsk cveqpelkgh dlefclygre ehlttngyrk ipgdkcqggv npvrevkdlk 
               
               
                 601 
                 kkctsnflsp ekqnsksnsv piilaivglm lvtvvagvli vkkyvcggrf lvhrysvlqq 
               
               
                 661 
                 haeangvdgv daldtashtn ksgyhddsde dlle 
               
               
                   
               
               
                 Gene ID: 
                 X11 
               
               
                 Gene symbol: 
                 ATP1B1 
               
               
                 Gene description: 
                 sodium/potassium-transporting ATPase subunit beta-1 
               
               
                 Unigene: 
                 Hs.291196 
               
               
                 Genbank: 
                 U16799 
               
               
                 Entrez Gene: 
                 481 
               
               
                 Refseq: 
                 NM__001677 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (19)): 
               
            
           
           
               
               
            
               
                 1 
                 margkakeeg swkkfiwnse kkeflgrtgg swfkillfyv ifygclagif igtiqvmllt 
               
               
                 61 
                 isefkptyqd rvappgltqi pqiqkteisf rpndpksyea yvlnivrfle kykdsaqrdd 
               
               
                 121 
                 mifedcgdvp sepkergdfn hergerkvcr fklewlgncs glndetygyk egkpciiikl 
               
               
                 181 
                 nrvlgfkpkp pknesletyp vmkynpnvlp vqctgkrded kdkvgnveyf glgnspgfpl 
               
               
                 241 
                 qyypyygkll qpkylqplla vqftnltmdt eirieckayg enigysekdr fqgrfdvkie 
               
               
                 301 
                 vks 
               
               
                   
               
               
                 Gene ID: 
                 X12 
               
               
                 Gene symbol: 
                 AGRN 
               
               
                 Gene description: 
                 Agrin 
               
               
                 Unigene: 
                 Hs.273330 
               
               
                 Genbank: 
                 AB191264 
               
               
                 Entrez Gene: 
                 375790 
               
               
                 Refseq: 
                 NM_198576 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (20)): 
               
            
           
           
               
               
            
               
                 1 
                 magrshpgpl rpllpllvva acvlpgaggt cperalerre eeanvvltgt veeilnvdpv 
               
               
                 61 
                 qhtysckvrv wrylkgkdlv areslldggn kvvisgfgdp licdnqvstg dtriffvnpa 
               
               
                 121 
                 ppylwpahkn elmlnsslmr itlrnleeve fcvedkpgth ftpvpptppd acrgmlcgfg 
               
               
                 181 
                 avcepnaegp grascvckks pcpsvvapvc gsdastysne celqraqcsq qrrirllsrg 
               
               
                 241 
                 pcgsrdpcsn vtcsfgstca rsadgltasc lcpatcrgap egtvcgsdga dypgecqllr 
               
               
                 301 
                 racarqenvf kkfdgpcdpc qgalpdpsrs crvnprtrrp emllrpescp arqapvcgdd 
               
               
                 361 
                 gvtyendcvm grsgaargll lqkvrsgqcq grdqcpeper fnavclsrrg rprcscdrvt 
               
               
                 421 
                 cdgayrpvca qdgrtydsdc wrqqaecrqq raipskhqgp cdqapspclg vqcafgatca 
               
               
                 481 
                 vkngqaacec lqacsslydp vcgsdgvtyg saceleatac tlgreiqvar kgpcdrcgqc 
               
               
                 541 
                 rfgalceaet grcvcpsecv alaqpvcgsd ghtypsecml hvhacthqis lhvasagpce 
               
               
                 601 
                 tcgdavcafg avcsagqcvc prcehpppgp vcgsdgvtyg sacelreaac lqqtqieear 
               
               
                 661 
                 agpceqaecg sggsgsgedg dceqelcrqr ggiwdedsed gpcvcdfscq svpgspvcgs 
               
               
                 721 
                 dgvtystece lkkarcesqr glyvaaqgac rgptfaplpp vaplhcaqtp ygccqdnita 
               
               
                 781 
                 argvglagcp sacqcnphgs yggtcdpatg qcscrpgvgg lrcdrcepgf wnfrgivtdg 
               
               
                 841 
                 rsgctpcscd pqgavrddce qmtglcsckp gvagpkcgqc pdgralgpag ceadasapat 
               
               
                 901 
                 caemrcefga rcveesgsah cvcpmltcpe anatkvcgsd gvtygnecql ktiacrqglq 
               
               
                 961 
                 isiqslgpcq eavapsthpt sasvtvttpg lllsqalpap pgalplapss tahsqttppp 
               
               
                 1021 
                 ssrprttasv prttvwpvlt vpptapspap slvasafges gstdgssdee lsgdqeasgg 
               
               
                 1081 
                 gsgglepleg ssvatpgppv erascynsal gccsdgktps ldaegsncpa tkvfqgvlel 
               
               
                 1141 
                 egvegqelfy tpemadpkse lfgetarsie stlddlfrns dvkkdfrsvr lrdlgpgksv 
               
               
                 1201 
                 raivdvhfdp ttafrapdva rallrqiqvs rrrslgvrrp lqehvrfmdf dwfpafitga 
               
               
                 1261 
                 tsgaiaagat arattasrlp ssavtpraph pshtsqpvak ttaapttrrp pttapsrvpg 
               
               
                 1321 
                 rrppapqqpp kpcdsqpcfh ggtcqdwalg ggftcscpag rggavcekvl gapvpafegr 
               
               
                 1381 
                 sflafptlra yhtlrlalef ralepqglll yngnargkdf lalalldgrv qlrfdtgsgp 
               
               
                 1441 
                 avltsavpve pgqwhrlels rhwrrgtlsv dgetpvlges psgtdglnld tdlfvggvpe 
               
               
                 1501 
                 dqaavalert fvgaglrgci rlldvnnqrl elgigpgaat rgsgvgecgd hpclpnpchg 
               
               
                 1561 
                 gapcqnleag rfhcqcppgr vgptcadeks pcqpnpchga apcrvlpegg aqcecplgre 
               
               
                 1621 
                 gtfcqtasgq dgsgpfladf ngfshlelrg lhtfardlge kmalevvfla rgpsglllyn 
               
               
                 1681 
                 gqktdgkgdf vslalrdrrl efrydlgkga avirsrepvt lgawtrvsle rngrkgalrv 
               
               
                 1741 
                 gdgprvlges pvphtvlnlk eplyvggapd fsklaraaav ssgfdgaiql vslggrqllt 
               
               
                 1801 
                 pehvlrqvdv tsfaghpctr asghpclnga scvpreaayv clcpggfsgp hcekglveks 
               
               
                 1861 
                 agdvdtlafd grtfveylna vtesekalqs nhfelslrte atqglvlwsg kateradyva 
               
               
                 1921 
                 laivdghlql synlgsqpvv lrstvpvntn rwlrvvahre qregslqvgn eapvtgsspl 
               
               
                 1981 
                 gatqldtdga lwlgglpelp vgpalpkayg tgfvgclrdv vvgrhplhll edavtkpelr 
               
               
                 2041 
                 pcptp 
               
               
                   
               
               
                 Gene ID: 
                 X13 
               
               
                 Gene symbol: 
                 APP 
               
               
                 Gene description: 
                 Amyloid beta A4 protein 
               
               
                 Unigene: 
                 Hs.434980 
               
               
                 Genbank: 
                   
               
               
                   
                 BC065529 | AF282245 | AK298861 | AK294534 | AK295621 | AK296229 | AK297412 | 
               
               
                   
                 AK297229 | AK295373 | BC004369 | M16765 | AK311717 
               
               
                 Entrez Gene: 
                 351 
               
               
                 Refseq: 
                 NM_000484 | NM_201413 | NM_001136130 | NM_201414 | NM_001136129 
               
            
           
           
               
            
               
                 Protein sequence isoform a (SEQ ID NO (21)): 
               
            
           
           
               
               
            
               
                 1 
                 mlpglallll aawtaralev ptdgnaglla epqiamfcgr lnmhmnvqng kwdsdpsgtk 
               
               
                 61 
                 tcidtkegil qycqevypel qitnvveanq pvtiqnwckr grkqckthph fvipyrclvg 
               
               
                 121 
                 efvsdallvp dkckflhqer mdvcethlhw htvaketcse kstnlhdygm llpcgidkfr 
               
               
                 181 
                 gvefvccpla eesdnvdsad aeeddsdvww ggadtdyadg sedkvvevae eeevaeveee 
               
               
                 241 
                 eadddedded gdeveeeaee pyeeatertt siattttttt esveevvrev cseqaetgpc 
               
               
                 301 
                 ramisrwyfd vtegkcapff yggcggnrnn fdteeycmav cgsamsqsll kttqeplard 
               
               
                 361 
                 pvklpttaas tpdavdkyle tpgdenehah fqkakerlea khrermsqvm reweeaerqa 
               
               
                 421 
                 knlpkadkka viqhfqekve sleqeaaner qqlvethmar veamlndrrr lalenyital 
               
               
                 481 
                 qavpprprhv fnmlkkyvra eqkdrqhtlk hfehvrmvdp kkaaqirsqv mthlrviyer 
               
               
                 541 
                 mnqslsllyn vpavaeeiqd evdellqkeq nysddvlanm iseprisygn dalmpsltet 
               
               
                 601 
                 kttvellpvn gefslddlqp whsfgadsvp antenevepv darpaadrgl ttrpgsgltn 
               
               
                 661 
                 ikteeisevk mdaefrhdsg yevhhqklvf faedvgsnkg aiiglmvggv viatvivitl 
               
               
                 721 
                 vmlkkkqyts ihhgvvevda avtpeerhls kmqqngyenp tykffeqmqn 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform b (SEQ ID NO (22)): 
               
            
           
           
               
               
            
               
                 1 
                 mlpglallll aawtaralev ptdgnaglla epqiamfcgr lnmhmnvqng kwdsdpsgtk 
               
               
                 61 
                 tcidtkegil qycqevypel qitnvveanq pvtiqnwckr grkqckthph fvipyrclvg 
               
               
                 121 
                 efvsdallvp dkckflhqer mdvcethlhw htvaketcse kstnlhdygm llpcgidkfr 
               
               
                 181 
                 gvefvccpla eesdnvdsad aeeddsdvww ggadtdyadg sedkvvevae eeevaeveee 
               
               
                 241 
                 eadddedded gdeveeeaee pyeeatertt siattttttt esveevvrev cseqaetgpc 
               
               
                 301 
                 ramisrwyfd vtegkcapff yggcggnrnn fdteeycmav cgsaipttaa stpdavdkyl 
               
               
                 361 
                 etpgdeneha hfqkakerle akhrermsqv mreweeaerq aknlpkadkk aviqhfqekv 
               
               
                 421 
                 esleqeaane rqqlvethma rveamlndrr rlalenyita lqavpprprh vfnmlkkyvr 
               
               
                 481 
                 aeqkdrqhtl khfehvrmvd pkkaaqirsq vmthlrviye rmnqslslly nvpavaeeiq 
               
               
                 541 
                 devdellqke qnysddvlan miseprisyg ndalmpslte tkttvellpv ngefslddlq 
               
               
                 601 
                 pwhsfgadsv pantenevep vdarpaadrg lttrpgsglt nikteeisev kmdaefrhds 
               
               
                 661 
                 gyevhhqklv ffaedvgsnk gaiiglmvgg vviatvivit lvmlkkkqyt sihhgvvevd 
               
               
                 721 
                 aavtpeerhl skmqqngyen ptykffeqmq n 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform f (SEQ ID NO(23)): 
               
            
           
           
               
               
            
               
                 1 
                 mlpglallll aawtaralev ypelqitnvv eanqpvtiqn wckrgrkqck thphfvipyr 
               
               
                 61 
                 clvgefvsda llvpdkckfl hqermdvcet hlhwhtvake tcsekstnlh dygmllpcgi 
               
               
                 121 
                 dkfrgvefvc cplaeesdnv dsadaeedds dvwwggadtd yadgsedkvv evaeeeevae 
               
               
                 181 
                 veeeeaddde ddedgdevee eaeepyeeat erttsiattt ttttesveev vrevcseqae 
               
               
                 241 
                 tgperamisr wyfdvtegkc apffyggcgg nrnnfdteey cmavcgsams qsllkttqep 
               
               
                 301 
                 lardpvklpt taastpdavd kyletpgden ehahfqkake rleakhrerm sqvmreweea 
               
               
                 361 
                 erqaknlpka dkkaviqhfq ekvesleqea anerqqlvet hmarveamln drrrlaleny 
               
               
                 421 
                 italqavppr prhvfnmlkk yvraeqkdrq htlkhfehvr mvdpkkaaqi rsqvmthlrv 
               
               
                 481 
                 iyermnqsls llynvpavae eiqdevdell qkeqnysddv lanmisepri sygndalmps 
               
               
                 541 
                 ltetkttvel lpvngefsld dlqpwhsfga dsvpantene vepvdarpaa drglttrpgs 
               
               
                 601 
                 gltnikteei sevkmdaefr hdsgyevhhq klvffaedvg snkgaiiglm vggvviatvi 
               
               
                 661 
                 vitlvmlkkk qytsihhgvv evdaavtpee rhlskmqqng yenptykffe qmqn 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform c (SEQ ID NO (24)): 
               
            
           
           
               
               
            
               
                 1 
                 mlpglallll aawtaralev ptdgnaglla epqiamfcgr lnmhmnvqng kwdsdpsgtk 
               
               
                 61 
                 tcidtkegil qycqevypel qitnvveanq pvtiqnwckr grkqckthph fvipyrclvg 
               
               
                 121 
                 efvsdallvp dkckflhqer mdvcethlhw htvaketcse kstnlhdygm llpcgidkfr 
               
               
                 181 
                 gvefvccpla eesdnvdsad aeeddsdvww ggadtdyadg sedkvvevae eeevaeveee 
               
               
                 241 
                 eadddedded gdeveeeaee pyeeatertt siattttttt esveevvrvp ttaastpdav 
               
               
                 301 
                 dkyletpgde nehahfqkak erleakhrer msqvmrewee aerqaknlpk adkkaviqhf 
               
               
                 361 
                 qekvesleqe aanerqqlve thmarveaml ndrrrlalen yitalqavpp rprhvfnmlk 
               
               
                 421 
                 kyvraeqkdr qhtlkhfehv rmvdpkkaaq irsqvmthlr viyermnqsl sllynvpava 
               
               
                 481 
                 eeiqdevdel lqkeqnysdd vlanmisepr isygndalmp sltetkttve llpvngefsl 
               
               
                 541 
                 ddlqpwhsfg adsvpanten evepvdarpa adrglttrpg sgltniktee isevkmdaef 
               
               
                 601 
                 rhdsgyevhh qklvffaedv gsnkgaiigl mvggvviatv ivitivmlkk kqytsihhgv 
               
               
                 661 
                 vevdaavtpe erhlskmqqn gyenptykff eqmqn 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform e (SEQ ID NO (25)): 
               
            
           
           
               
               
            
               
                 1 
                 mlpglallll aawtaralev ypelqitnvv eanqpvtiqn wckrgrkqck thphfvipyr 
               
               
                 61 
                 clvgefvsda llvpdkckfl hqermdvcet hlhwhtvake tcsekstnlh dygmllpcgi 
               
               
                 121 
                 dkfrgvefvc cplaeesdnv dsadaeedds dvwwggadtd yadgsedkvv evaeeeevae 
               
               
                 181 
                 veeeeaddde ddedgdevee eaeepyeeat erttsiattt ttttesveev vrvpttaast 
               
               
                 241 
                 pdavdkylet pgdenehahf qkakerleak hrermsqvmr eweeaerqak nlpkadkkav 
               
               
                 301 
                 iqhfqekves leqeaanerq qlvethmarv eamlndrrrl alenyitalq avpprprhvf 
               
               
                 361 
                 nmlkkyvrae qkdrqhtlkh fehvrmvdpk kaaqirsqvm thlrviyerm nqslsllynv 
               
               
                 421 
                 pavaeeiqde vdellqkeqn ysddvlanmi seprisygnd almpsltetk ttvellpvng 
               
               
                 481 
                 efslddlqpw hsfgadsvpa ntenevepvd arpaadrglt trpgsgltni kteeisevkm 
               
               
                 541 
                 daefrhdsgy evhhqklvff aedvgsnkga iiglmvggvv iatvivitlv mlkkkqytsi 
               
               
                 601 
                 hhgvvevdaa vtpeerhlsk mqqngyenpt ykffeqmqn 
               
               
                   
               
               
                 Gene ID: 
                 X14 
               
               
                 Gene symbol: 
                 COLEC12 
               
               
                 Gene description: 
                 Collectin sub-family member 12 
               
               
                 Unigene: 
                 Hs.464422 
               
               
                 Genbank: 
                 AB038518 
               
               
                 Entrez Gene: 
                 81035 
               
               
                 Refseq: 
                 NM_130386 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (26)): 
               
            
           
           
               
               
            
               
                 1 
                 mkddfaeeee vqsfgykrfg iqegtqctkc knnwalkfsi illyilcall titvailgyk 
               
               
                 61 
                 vvekmdnvtg gmetsrqtyd dkltavesdl kklgdqtgkk aistnselst frsdildlrq 
               
               
                 121 
                 qlreitekts knkdtleklq asgdalvdrq sqlketlenn sflittvnkt lqayngyvtn 
               
               
                 181 
                 lqqdtsvlqg nlqnqmyshn vvimnlnnln ltqvqqrnli tnlqrsvddt sqaiqriknd 
               
               
                 241 
                 fqnlqqvflq akkdtdwlke kvqslqtlaa nnsalakann dtledmnsql nsftgqmeni 
               
               
                 301 
                 ttisqaneqn lkdlqdlhkd aenrtaikfn qleerfqlfe tdivniisni sytahhlrtl 
               
               
                 361 
                 tsnlnevrtt ctdtltkhtd dltslnntla nirldsyslr mqqdlmrsrl dtevanlsvi 
               
               
                 421 
                 meemklvdsk hgqliknfti lqgppgprgp rgdrgsqgpp gptgnkgqkg ekgepgppgp 
               
               
                 481 
                 agergpigpa gppgerggkg skgsqgpkgs rgspgkpgpq gpsgdpgppg ppgkeglpgp 
               
               
                 541 
                 qgppgfqglq gtvgepgvpg prglpglpgv pgmpgpkgpp gppgpsgavv plalqneptp 
               
               
                 601 
                 apedngcpph wknftdkcyy fsvekeifed aklfcedkss hlvfintree qqwikkqmvg 
               
               
                 661 
                 reshwigltd serenewkwl dgtspdyknw kagqpdnwgh ghgpgedcag liyagqwndf 
               
               
                 721 
                 qcedvnnfic ekdretvlss al 
               
               
                   
               
               
                 Gene ID: 
                 X15 
               
               
                 Gene symbol: 
                 NCAM1 
               
               
                 Gene description: 
                 Neural cell adhesion molecule 1 
               
               
                 Unigene: 
                 Hs.503878 
               
               
                 Genbank: 
                 BC047244 
               
               
                 Entrez Gene: 
                 4684 
               
               
                 Refseq: 
                 NM_000615 | NM_001076682 | NM_181351 | NM_001242608 l 
               
               
                   
                 NM_001242607 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (27)): 
               
            
           
           
               
               
            
               
                 1 
                 mlqtkdliwt lfflgtavsl qvdivpsqge isvgeskffl cqvagdakdk diswfspnge 
               
               
                 61 
                 kltpnqqris vvwnddssst ltiynanidd agiykcvvtg edgseseatv nvkifqklmf 
               
               
                 121 
                 knaptpqefr egedavivcd vvsslpptii wkhkgrdvil kkdvrfivls nnylqirgik 
               
               
                 181 
                 ktdegtyrce grilargein fkdiqvivnv pptiqarqni vnatanlgqs vtlvcdaegf 
               
               
                 241 
                 peptmswtkd geqieqeedd ekyifsddss qltikkvdkn deaeyiciae nkageqdati 
               
               
                 301 
                 hlkvfakpki tyvenqtame leeqvtltce asgdpipsit wrtstrniss eektldghmv 
               
               
                 361 
                 vrsharvssl tlksiqytda geyictasnt igqdsqsmyl evqyapklqg pvavytwegn 
               
               
                 421 
                 qvnitcevfa ypsatiswfr dgqllpssny snikiyntps asylevtpds endfgnynct 
               
               
                 481 
                 avnrigqesl efilvqadtp sspsidqvep ysstaqvqfd epeatggvpi lkykaewrav 
               
               
                 541 
                 geevwhskwy dakeasmegi vtivglkpet tyavrlaaln gkglgeisaa sefktqpvqg 
               
               
                 601 
                 epsapklegq mgedgnsikv nlikqddggs pirhylvryr alssewkpei rlpsgsdhvm 
               
               
                 661 
                 lksldwnaey evyvvaenqq gkskaahfvf rtsaqptaip angsptsgls tgaivgiliv 
               
               
                 721 
                 ifvlllvvvd itcyflnkcg lfmciavnlc gkagpgakgk dmeegkaafs kdeskepive 
               
               
                 781 
                 vrteeertpn hdggkhtepn ettpltepek gpveakpecq etetkpapae vktvpndatq 
               
               
                 841 
                 tkeneska 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 3 (SEQ ID NO (28)): 
               
            
           
           
               
               
            
               
                 1 
                 mlqtkdliwt lfflgtavsl qvdivpsqge isvgeskffl cqvagdakdk diswfspnge 
               
               
                 61 
                 kltpnqqris vvwnddssst ltiynanidd agiykcvvtg edgseseatv nvkifqklmf 
               
               
                 121 
                 knaptpqefr egedavivcd vvsslpptii wkhkgrdvil kkdvrfivls nnylqirgik 
               
               
                 181 
                 ktdegtyrce grilargein fkdiqvivnv pptiqarqni vnatanlgqs vtlvcdaegf 
               
               
                 241 
                 peptmswtkd geqieqeedd ekyifsddss qltikkvdkn deaeyiciae nkageqdati 
               
               
                 301 
                 hlkvfakpki tyvenqtame leeqvtltce asgdpipsit wrtstrniss eektldghmv 
               
               
                 361 
                 vrsharvssl tlksiqytda geyictasnt igqdsqsmyl evqyapklqg pvavytwegn 
               
               
                 421 
                 qvnitcevfa ypsatiswfr dgqllpssny snikiyntps asylevtpds endfgnynct 
               
               
                 481 
                 avnrigqesl efilvqadtp sspsidqvep ysstaqvqfd epeatggvpi lkykaewrav 
               
               
                 541 
                 geevwhskwy dakeasmegi vtivglkpet tyavrlaaln gkglgeisaa sefktqpvhs 
               
               
                 601 
                 ppppasasss tpvplsppdt twplpalatt epakgepsap klegqmgedg nsikvnlikq 
               
               
                 661 
                 ddggspirhy lvryralsse wkpeirlpsg sdhvmlksld wnaeyevyvv aenqqgkska 
               
               
                 721 
                 ahfvfrtsaq ptaipatlgg nsasyffvsl lfsavtllll c 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (29)): 
               
            
           
           
               
               
            
               
                 1 
                 mlqtkdliwt lfflgtavsl qvdivpsqge isvgeskffl cqvagdakdk diswfspnge 
               
               
                 61 
                 kltpnqqris vvwnddssst ltiynanidd agiykcvvtg edgseseatv nvkifqklmf 
               
               
                 121 
                 knaptpqefr egedavivcd vvsslpptii wkhkgrdvil kkdvrfivls nnylqirgik 
               
               
                 181 
                 ktdegtyrce grilargein fkdiqvivnv pptiqarqni vnatanlgqs vtivcdaegf 
               
               
                 241 
                 peptmswtkd geqieqeedd ekyifsddss qltikkvdkn deaeyiciae nkageqdati 
               
               
                 301 
                 hlkvfakpki tyvenqtame leeqvtltce asgdpipsit wrtstrniss eekaswtrpe 
               
               
                 361 
                 kqetldghmv vrsharvssl tlksiqytda geyictasnt igqdsqsmyl evqyapklqg 
               
               
                 421 
                 pvavytwegn qvnitcevfa ypsatiswfr dgqllpssny snikiyntps asylevtpds 
               
               
                 481 
                 endfgnynct avnrigqesl efilvqadtp sspsidqvep ysstaqvqfd epeatggvpi 
               
               
                 541 
                 lkykaewrav geevwhskwy dakeasmegi vtivglkpet tyavrlaaln gkglgeisaa 
               
               
                 601 
                 sefktqpvqg epsapklegq mgedgnsikv nlikqddggs pirhylvryr alssewkpei 
               
               
                 661 
                 rlpsgsdhvm lksldwnaey evyvvaenqq gkskaahfvf rtsaqptaip angsptsgls 
               
               
                 721 
                 tgaivgiliv ifvlllvvvd itcyflnkcg lfmciavnlc gkagpgakgk dmeegkaafs 
               
               
                 781 
                 kdeskepive vrteeertpn hdggkhtepn ettpltepek gpveakpecq etetkpapae 
               
               
                 841 
                 vktvpndatq tkeneska 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 4 (SEQ ID NO(30)): 
               
            
           
           
               
               
            
               
                 1 
                 mlqtkdliwt lfflgtavsl qvdivpsqge isvgeskffl cqvagdakdk diswfspnge 
               
               
                 61 
                 kltpnqqris vvwnddssst ltiynanidd agiykcvvtg edgseseatv nvkifqklmf 
               
               
                 121 
                 knaptpqefr egedavivcd vvsslpptii wkhkgrdvil kkdvrfivls nnylqirgik 
               
               
                 181 
                 ktdegtyrce grilargein fkdiqvivnv pptiqarqni vnatanlgqs vtlvcdaegf 
               
               
                 241 
                 peptmswtkd geqieqeedd ekyifsddss qltikkvdkn deaeyiciae nkageqdati 
               
               
                 301 
                 hlkvfakpki tyvenqtame leeqvtltce asgdpipsit wrtstrniss eektldghmv 
               
               
                 361 
                 vrsharvssl tlksiqytda geyictasnt igqdsqsmyl evqyapklqg pvavytwegn 
               
               
                 421 
                 qvnitcevfa ypsatiswfr dgqllpssny snikiyntps asylevtpds endfgnynct 
               
               
                 481 
                 avnrigqesl efilvqadtp sspsidqvep ysstaqvqfd epeatggvpi lkykaewrav 
               
               
                 541 
                 geevwhskwy dakeasmegi vtivglkpet tyavrlaaln gkglgeisaa sefktqpvqg 
               
               
                 601 
                 epsapklegq mgedgnsikv nlikqddggs pirhylvryr alssewkpei rlpsgsdhvm 
               
               
                 661 
                 lksldwnaey evyvvaenqq gkskaahfvf rtsaqptaip atlggnsasy tfvsllfsav 
               
               
                 721 
                 tllllc 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 5 (SEQ ID NO (31)): 
               
            
           
           
               
               
            
               
                 1 
                 mlqtkdliwt lfflgtavsl qvdivpsqge isvgeskffl cqvagdakdk diswfspnge 
               
               
                 61 
                 kltpnqqris vvwnddssst ltiynanidd agiykcvvtg edgseseatv nvkifqklmf 
               
               
                 121 
                 knaptpqefr egedavivcd vvsslpptii wkhkgrdvil kkdvrfivls nnylqirgik 
               
               
                 181 
                 ktdegtyrce grilargein fkdiqvivnv pptiqarqni vnatanlgqs vtlvcdaegf 
               
               
                 241 
                 peptmswtkd geqieqeedd ekyifsddss qltikkvdkn deaeyiciae nkageqdati 
               
               
                 301 
                 hlkvfakpki tyvenqtame leeqvtltce asgdpipsit wrtstrniss eekaswtrpe 
               
               
                 361 
                 kqevhapwnw qvgrqkgqag sagfpgshet ldghmvvrsh arvssltlks iqytdageyi 
               
               
                 421 
                 ctasntigqd sqsmylevqy apklqgpvav ytwegnqvni tcevfaypsa tiswfrdgql 
               
               
                 481 
                 lpssnysnik iyntpsasyl evtpdsendf gnynctavnr igqeslefil vqadtpssps 
               
               
                 541 
                 idqvepysst aqvqfdepea tggvpilkyk aewravgeev whskwydake asmegivtiv 
               
               
                 601 
                 glkpettyav rlaalngkgl geisaasefk tqpvqgepsa pklegqmged gnsikvnlik 
               
               
                 661 
                 qddggspirh ylvryralss ewkpeirlps gsdhvmlksl dwnaeyevyv vaenqqgksk 
               
               
                 721 
                 aahfvfrtsa qptaipangs ptsglstgai vgilivifvl llvvvditcy flnkcglfmc 
               
               
                 781 
                 iavnlcgkag pgakgkdmee gkaafskdes kepivevrte eertpnhdgg khtepnettp 
               
               
                 841 
                 ltepekgpve akpecqetet kpapaevktv pndatqtken eska 
               
               
                   
               
               
                 Gene ID: 
                 X16 
               
               
                 Gene symbol: 
                 NRP2 
               
               
                 Gene description: 
                 Neuropilin-2 
               
               
                 Unigene: 
                 Hs.471200 
               
               
                 Genbank: 
                 BX537423 | AF016098 | BC101525 | BC104770 |BC117413 | BC143238 | BC143608 | 
               
               
                   
                 AF022860 | AF280545 | AF280544 | AF022859 | AK290934 | AF280546 | 
               
               
                   
                 BC009222 | AL833606 | BX648292 | AK130198 | BC018631 
               
               
                 Entrez Gene: 
                 8828 
               
               
                 Refseq: 
                   
               
               
                   
                 NM_201266 | NM_003872 | NM_201279 | NM_0185341NM_201267 | NM_201264 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (32)): 
               
            
           
           
               
               
            
               
                 1 
                 mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy 
               
               
                 61 
                 apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml 
               
               
                 121 
                 yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil 
               
               
                 181 
                 akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs 
               
               
                 241 
                 stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys 
               
               
                 301 
                 dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks 
               
               
                 361 
                 yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial 
               
               
                 421 
                 rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq 
               
               
                 481 
                 aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd 
               
               
                 541 
                 prtqqpklfe gnmhydtpdi rrfdpipaqy vrvyperwsp agigmrlevl gcdwtdskpt 
               
               
                 601 
                 vetlgptvks eetttpypte eeatecgenc sfeddkdlql psgfncnfdf leepcgwmyd 
               
               
                 661 
                 hakwlrttwa sssspndrtf pddrnflrlq sdsqregqya rlisppvhlp rspvcmefqy 
               
               
                 721 
                 qatggrgval qvvreasqes kllwviredq ggewkhgrii lpsydmeyqi vfegvigkgr 
               
               
                 781 
                 sgeiaiddir litdvplenc mepisafage nfkvdipeih eregyedeid deyevdwsns 
               
               
                 841 
                 ssatsgsgap stdkekswly tldpilitii amsslgvllg atcaglllyc tcsysglssr 
               
               
                 901 
                 scttlenynf elydglkhkv kmnhqkccse a 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (33)): 
               
            
           
           
               
               
            
               
                 1 
                 mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy 
               
               
                 61 
                 apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml 
               
               
                 121 
                 yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil 
               
               
                 181 
                 akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs 
               
               
                 241 
                 stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys 
               
               
                 301 
                 dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks 
               
               
                 361 
                 yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial 
               
               
                 421 
                 rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq 
               
               
                 481 
                 aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd 
               
               
                 541 
                 prtqqpklfe gnmhydtpdi rrfdpipaqy vrvyperwsp agigmrlevl gcdwtdskpt 
               
               
                 601 
                 vetlgptvks eetttpypte eeatecgenc sfeddkdlql psgfncnfdf leepcgwmyd 
               
               
                 661 
                 hakwlrttwa sssspndrtf pddrnflrlq sdsqregqya rlisppvhlp rspvcmefqy 
               
               
                 721 
                 qatggrgval qvvreasqes kllwviredq ggewkhgrii lpsydmeyqi vfegvigkgr 
               
               
                 781 
                 sgeiaiddir istdvplenc mepisafavd ipeiheregy edeiddeyev dwsnsssats 
               
               
                 841 
                 gsgapstdke kswlytldpi litiiamssl gvllgatcag lllyctcsys glssrscttl 
               
               
                 901 
                 enynfelydg lkhkvkmnhq kccsea 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 3 (SEQ ID NO (34)): 
               
            
           
           
               
               
            
               
                 1 
                 mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy 
               
               
                 61 
                 apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml 
               
               
                 121 
                 yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil 
               
               
                 181 
                 akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs 
               
               
                 241 
                 stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys 
               
               
                 301 
                 dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks 
               
               
                 361 
                 yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial 
               
               
                 421 
                 rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq 
               
               
                 481 
                 aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd 
               
               
                 541 
                 prtqqpklfe gnmhydtpdi rrfdpipaqy vrvyperwsp agigmrlevl gcdwtdskpt 
               
               
                 601 
                 vetlgptvks eetttpypte eeatecgenc sfeddkdlql psgfncnfdf leepcgwmyd 
               
               
                 661 
                 hakwlrttwa sssspndrtf pddrnflrlq sdsqregqya rlisppvhlp rspvcmefqy 
               
               
                 721 
                 qatggrgval qvvreasqes kllwviredq ggewkhgrii lpsydmeyqi vfegvigkgr 
               
               
                 781 
                 sgeiaiddir istdvplenc mepisafade yevdwsnsss atsgsgapst dkekswlytl 
               
               
                 841 
                 dpilitiiam sslgvllgat caglllyctc sysglssrsc ttlenynfel ydglkhkvkm 
               
               
                 901 
                 nhqkccsea 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 4 (SEQ ID NO (35)): 
               
            
           
           
               
               
            
               
                 1 
                 mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy 
               
               
                 61 
                 apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml 
               
               
                 121 
                 yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil 
               
               
                 181 
                 akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs 
               
               
                 241 
                 stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys 
               
               
                 301 
                 dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks 
               
               
                 361 
                 yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial 
               
               
                 421 
                 rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq 
               
               
                 481 
                 aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd 
               
               
                 541 
                 prtqqpklfe gnmhydtpdi rrfdpipaqy vrvyperwsp agigmrlevl gcdwtdskpt 
               
               
                 601 
                 vetlgptvks eetttpypte eeatecgenc sfeddkdlql psgfncnfdf leepcgwmyd 
               
               
                 661 
                 hakwlrttwa sssspndrtf pddrnflrlq sdsqregqya rlisppvhlp rspvcmefqy 
               
               
                 721 
                 qatggrgval qvvreasqes kllwviredq ggewkhgrii lpsydmeyqi vfegvigkgr 
               
               
                 781 
                 sgeiaiddir istdvplenc mepisafage nfkggtllpg teptvdtvpm qpipaywyyv 
               
               
                 841 
                 maaggavlvl vsvalalvlh yhrfryaakk tdhsitykts hytngaplav eptltikleq 
               
               
                 901 
                 drgshc 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 5 (SEQ ID NO (36)): 
               
            
           
           
               
               
            
               
                 1 
                 mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy 
               
               
                 61 
                 apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml 
               
               
                 121 
                 yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil 
               
               
                 181 
                 akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs 
               
               
                 241 
                 stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys 
               
               
                 301 
                 dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks 
               
               
                 361 
                 yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial 
               
               
                 421 
                 rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq 
               
               
                 481 
                 aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd 
               
               
                 541 
                 prtqqpklfe gnmhydtpdi rrfdpipaqy vrvyperwsp agigmrlevl gcdwtdskpt 
               
               
                 601 
                 vetlgptvks eetttpypte eeatecgenc sfeddkdlql psgfncnfdf leepcgwmyd 
               
               
                 661 
                 hakwlrttwa sssspndrtf pddrnflrlq sdsqregqya rlisppvhlp rspvcmefqy 
               
               
                 721 
                 qatggrgval qvvreasqes kllwviredq ggewkhgrii lpsydmeyqi vfegvigkgr 
               
               
                 781 
                 sgeiaiddir istdvplenc mepisafagg tllpgteptv dtvpmqpipa ywyyvmaagg 
               
               
                 841 
                 avlvlvsval alvlhyhrfr yaakktdhsi tyktshytng aplaveptlt ikleqdrgsh 
               
               
                 901 
                 c 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 6 (SEQ ID NO (37)): 
               
            
           
           
               
               
            
               
                 1 
                 mdmfpltwvf lalyfsrhqv rgqpdppcgg rlnskdagyi tspgypqdyp shqncewivy 
               
               
                 61 
                 apepnqkivl nfnphfeiek hdckydfiei rdgdsesadl lgkhcgniap ptiissgsml 
               
               
                 121 
                 yikftsdyar qgagfslrye ifktgsedcs knftspngti espgfpekyp hnldctftil 
               
               
                 181 
                 akpkmeiilq flifdlehdp lqvgegdcky dwldiwdgip hvgpligkyc gtktpselrs 
               
               
                 241 
                 stgilsltfh tdmavakdgf saryylvhqe plenfqcnvp lgmesgrian eqisasstys 
               
               
                 301 
                 dgrwtpqqsr lhgddngwtp nldsnkeylq vdlrfltmlt aiatqgaisr etqngyyvks 
               
               
                 361 
                 yklevstnge dwmvyrhgkn hkvfqannda tevvlnklha plltrfvrir pqtwhsgial 
               
               
                 421 
                 rlelfgcrvt dapcsnmlgm lsgliadsqi sasstqeylw spsaarlvss rsgwfpripq 
               
               
                 481 
                 aqpgeewlqv dlgtpktvkg viiqgarggd sitavearaf vrkfkvsysl ngkdweyiqd 
               
               
                 541 
                 prtqqpkvgc swrpl 
               
               
                   
               
               
                 Gene ID: 
                 X17 
               
               
                 Gene symbol: 
                 PLXNA2 
               
               
                 Gene description: 
                 Plexin-A2 
               
               
                 Unigene: 
                 Hs.497626 
               
               
                 Genbank: 
                 BC132676 
               
               
                 Entrez Gene: 
                 5362 
               
               
                 Refseq: 
                 NM__025179 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (38)): 
               
            
           
           
               
               
            
               
                 1 
                 meqrrpwpra levdsrsvvl lsvvwvllap paagmpqfst fhsenrdwtf nhltvhqgtg 
               
               
                 61 
                 avyvgainrv ykltgnltiq vahktgpeed nkscyppliv qpcsevltlt nnvnklliid 
               
               
                 121 
                 ysenrllacg slyqgvckll rlddlfilve pshkkehyls svnktgtmyg vivrsegedg 
               
               
                 181 
                 klfigtavdg kqdyfptlss rklprdpess amldyelhsd fvsslikips dtlalvshfd 
               
               
                 241 
                 ifyiygfasg gfvyfltvqp etpegvains agdlfytsri vrlckddpkf hsyvslpfgc 
               
               
                 301 
                 tragveyrll qaaylakpgd slaqafnits qddvlfaifs kgqkqyhhpp ddsalcafpi 
               
               
                 361 
                 rainlqiker lqscyqgegn lelnwllgkd vqctkapvpi ddnfcgldin qplggstpve 
               
               
                 421 
                 gltlyttsrd rmtsvasyvy ngysvvfvgt ksgklkkira dgpphggvqy emvsylkdgs 
               
               
                 481 
                 pilrdmafsi dqrylyvmse rqvtrvpves ceqyttcgec lssgdphcgw calhnmcsrr 
               
               
                 541 
                 dkcqqawepn rfaasisqcv slavhpssis vsehsrllsl vvsdapdlsa giacafgnlt 
               
               
                 601 
                 evegqvsgsq vicispgpkd vpvipldqdw fglelqlrsk etgkifvste fkfyncsahq 
               
               
                 661 
                 lclscvnsaf rchwckyrnl cthdpttcsf qegrinised cpqlvpteei lipvgevkpi 
               
               
                 721 
                 tlkarnlpqp qsgqrgyecv lniqgaihrv palrfnsssv qcqnssyqyd gmdisnlavd 
               
               
                 781 
                 favvwngnfi idnpqdlkvh lykcaagres cglclkadrk fecgwcsger rctlhqhcts 
               
               
                 841 
                 psspwldwss hnvkcsnpqi teiltvsgpp eggtrvtihg vnlgldfsei ahhvqvagvp 
               
               
                 901 
                 ctplpgeyii aeqivcemgh alvgttsgpv rlcigeckpe fmtkshqqyt fvnpsvlsln 
               
               
                 961 
                 pirgpesggt mvtitghylg agssvavylg nqtcefygrs mseivcvspp ssnglgpvpv 
               
               
                 1021 
                 sysvdrahvd snlqfeyidd prvqriepew siasghtplt itgfnldviq eprirvkfng 
               
               
                 1081 
                 kesvnyckvv ntttltclap slttdyrpgl dtverpdefg fvfnnvqsll iyndtkfiyy 
               
               
                 1141 
                 pnptfellsp tgvldqkpgs piilkgknlc ppasggakln ytvligetpc avtvsetqll 
               
               
                 1201 
                 ceppnitgqh kvmvhvggmv fspgsysvis dslltlpaiv siaaggslll iiviivliay 
               
               
                 1261 
                 krksrendlt lkrlqmqmdn lesrvaleck eafaelqtdi neltsdldrs gipyldyrty 
               
               
                 1321 
                 amrvlfpgie dhpvlrelev qgngqqhvek alklfaqlin nkvflltfir tlelqrsfsm 
               
               
                 1381 
                 rdrgnvasli mtglqgrley atdvlkqlls dlidknlenk nhpklllrrt esvaekmltn 
               
               
                 1441 
                 wfafllhkfl kecageplfm lycaikqqme kgpidaitge aryslsedkl irqqieyktl 
               
               
                 1501 
                 ilncvnpdne nspeipvkvl ncdtitqvke kildavyknv pysqrpravd mdlewrqgri 
               
               
                 1561 
                 arvvlqdedi ttkiegdwkr lntlmhyqvs drsvvalvpk qtssynipas asisrtsisr 
               
               
                 1621 
                 ydssfrytgs pdslrsrapm itpdlesgvk vwhlvknhdh gdqkegdrgs kmvseiyltr 
               
               
                 1681 
                 llatkgtlqk fvddlfetlf stvhrgsalp laikymfdfl deqadrhsih dtdvrhtwks 
               
               
                 1741 
                 nclplrfwvn viknpqfvfd ihkgsitdac lsvvaqtfmd scstsehrlg kdspsnklly 
               
               
                 1801 
                 akdipsyksw veryyadiak lpaisdqdmn aylaeqsrlh avefnmlsal neiysyvsky 
               
               
                 1861 
                 seeligaleq deqarrqrla ykveqlinam sies 
               
               
                   
               
               
                 Gene ID: 
                 X18 
               
               
                 Gene symbol: 
                 PCDHA4 
               
               
                 Gene description: 
                 Protocadherin alpha-4 
               
               
                 Unigene: 
                 Hs.199343 
               
               
                 Genbank: 
                 AF152482 | AF152312 
               
               
                 Entrez Gene: 
                 56144 
               
               
                 Refseq: 
                 NM_0189071 NM_031500 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (39)): 
               
            
           
           
               
               
            
               
                 1 
                 mefswgsgqe srrlllllll laaweagngq lhysyseeak hgtfvgriaq dlglelaelv 
               
               
                 61 
                 prlfrvaskg rggllevnlq ngilfvnsri dreelcrrsa ecsihleviv drplqvfhvd 
               
               
                 121 
                 vevrdindnp pvfpatqknl siaesrplds rfplegasda digenallty rlspneyfsl 
               
               
                 181 
                 ekppddelvk glglilrksl dreeapeifl vltatdggkp eltgtvqlli tvldandnap 
               
               
                 241 
                 afdrtiykvr llenvpngtl viklnasdld eglngdivys fsndispnvk skfhidpitg 
               
               
                 301 
                 qiivkgyidf eesksyeiiv egidkgqlpl sghcrvivev ednndnvpdl efkslslpir 
               
               
                 361 
                 edaplgtvia lisvsdkdmg vnglvtcslt shvpfklyst fknyyslvld saldresysa 
               
               
                 421 
                 yelvvtardg gspslwatas vsvevadvnd napafaqpey tvfvkennpp gchiftvsaw 
               
               
                 481 
                 dadaqenalv syslverrvg eralssyvsv haesgkvyal qpldheelel lqfqvtarda 
               
               
                 541 
                 gvpplgsnvt lqvfvldend napallapra ggtggavsel vpwsvgvghv vakvravdad 
               
               
                 601 
                 sgynawlsye lqpgtggari pfrvglytge isttraldet daprhrllvl vkdhgepalt 
               
               
                 661 
                 atatvlvslv esgqapkass ralvgavgpd aalvdvnvyl iiaicavssl lvltlllyta 
               
               
                 721 
                 lrcsalpteg acapgkptlv cssavgswsy sqqrrprvcs gegppktdlm afspslpdsr 
               
               
                 781 
                 dredqlqtte esfakprqpn pdwrysaslr agmhssvhle eagilragpg gpdqqwptvs 
               
               
                 841 
                 satpepeage vsppvgagvn snswtfkygp gnpkgsgpge lpdkfiipgs paiisirqep 
               
               
                 901 
                 tnsqidksdf itfgkkeetk kkkkkkkgnk tqekkekgns ttdnsdq 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (40)): 
               
            
           
           
               
               
            
               
                 1 
                 mefswgsgqe srrlllllll laaweagngq lhysvseeak hgtfvgriaq dlglelaelv 
               
               
                 61 
                 prlfrvaskg rggllevnlq ngilfvnsri dreelcrrsa ecsihleviv drplqvfhvd 
               
               
                 121 
                 vevrdindnp pvfpatqknl siaesrplds rfplegasda digenallty rlspneyfsl 
               
               
                 181 
                 ekppddelvk glglilrksl dreeapeifl vltatdggkp eltgtvqlli tvldandnap 
               
               
                 241 
                 afdrtiykvr llenvpngtl viklnasdld eglngdivys fsndispnvk skfhidpitg 
               
               
                 301 
                 qiivkgyidf eesksyeiiv egidkgqlpl sghcrvivev ednndnvpdl efkslslpir 
               
               
                 361 
                 edaplgtvia lisysdkdmg vnglvtcslt shvpfklvst fknyyslvld saldresysa 
               
               
                 421 
                 yelvvtardg gspslwatas vsvevadvnd napafaqpey tvfvkennpp gchiftvsaw 
               
               
                 481 
                 dadaqenalv syslverrvg eralssyvsv haesgkvyal qpldheelel lqfqvtarda 
               
               
                 541 
                 gvpplgsnvt lqvfvldend napallapra ggtggavsel vpwsvgvghv vakvravdad 
               
               
                 601 
                 sgynawlsye lqpgtggari pfrvglytge isttraldet daprhrllvl vkdhgepalt 
               
               
                 661 
                 atatvlvslv esgqapkass ralvgavgpd aalvdvnvyl iiaicavssl lvltlllyta 
               
               
                 721 
                 lrcsalpteg acapgkptlv cssavgswsy sqqrrprvcs gegppktdlm afspslpdsr 
               
               
                 781 
                 dredqlqtte esfakvsv 
               
               
                   
               
               
                 Gene ID: 
                 X19 
               
               
                 Gene symbol: 
                 PCDHAC2 
               
               
                 Gene description: 
                 Protocadherin alpha-C2 
               
               
                 Unigene: 
                 Hs.199343 
               
               
                 Genbank: 
                 AF152304 
               
               
                 Entrez Gene: 
                 56134 
               
               
                 Refseq: 
                 NM_018899 | NM_031883 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (41)): 
               
            
           
           
               
               
            
               
                 1 
                 meqagtrpaa tehprlrrpm pwllllplll llllllpgpa asqlrysvpe eqapgalvgn 
               
               
                 61 
                 varalglelr rlgpgclrin hlgapspryl eldltsgalf vneridreal ceqrprells 
               
               
                 121 
                 levlahnpva vsaveveild indnsprfpr pnyqlqvses vapgarfhie saqdpdvgan 
               
               
                 181 
                 svqtyelsps ehfeldlkpl genskvlelv lrkgldreqa alhhlvltav dggiparsgt 
               
               
                 241 
                 aqisvrvldt ndnspafdqs tyrvqlreds ppgtlcckln asdpdegsng elryslssyt 
               
               
                 301 
                 sdrerqlfsi dastgevrvi ggldyeeass yqiyvqatdr gpvpmaghck vlvdivdvnd 
               
               
                 361 
                 napevvltdl yspvpenatp ntivavlsvn dqdsgpnrkv slgleatlpf rlngfgnsyt 
               
               
                 421 
                 lvvsgpldre rvavynitvt atdggipqlt slrtlkveis dindnppsfl edsysiyiqe 
               
               
                 481 
                 nnlpgvllct vqatdpdeke naevtyslle reiqglpvts yvsinsasgs lyavnsfdye 
               
               
                 541 
                 kfreffctve aqdkgsppls stvtanvyvv dmndhaphil yptstnssaa femvprtapa 
               
               
                 601 
                 gylvtkviam dsdsgqnawl fyhlaqtsdl dlfkvelhtg eirttrkmgd esgstfnitv 
               
               
                 661 
                 vvrdngepsl sasvaitvav vdrvskilpd tqrhyksprt yseitlylii alstvsfifl 
               
               
                 721 
                 ltiiilsiik cyrytaygta ccggfcgvre rspaelykqa nnnidariph glkvqphfie 
               
               
                 781 
                 vrgngsltkt ycykacltag sgsdtfmfyn tgaqtgpgps gaqaavtdsr nltgqsgqna 
               
               
                 841 
                 gnliilknea vsqneprqpn pdwrysaslr agmhssvhle eagilragpg gpdqqwptvs 
               
               
                 901 
                 satpepeage vsppvgagvn snswtfkygp gnpkgsgpge lpdkfiipgs paiisirqep 
               
               
                 961 
                 tnsqidksdf itfgkkeetk kkkkkkkgnk tqekkekgns ttdnsdq 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (42)): 
               
            
           
           
               
               
            
               
                 1 
                 meqagtrpaa tehprlrrpm pwllllplll llllllpgpa asqlrysvpe eqapgalvgn 
               
               
                 61 
                 varalglelr rlgpgclrin hlgapspryl eldltsgalf vneridreal ceqrprclls 
               
               
                 121 
                 levlahnpva vsaveveild indnsprfpr pnyqlqvses vapgarfhie saqdpdvgan 
               
               
                 181 
                 svqtyelsps ehfeldlkpl qenskvlelv lrkgldreqa alhhlvltav dggiparsgt 
               
               
                 241 
                 aqisvrvldt ndnspafdqs tyrvqlreds ppgtlvvkln asdpdegsng elryslssyt 
               
               
                 301 
                 sdrerqlfsi dastgevrvi ggldyeeass yqiyvqatdr gpvpmaghck vlvdivdvnd 
               
               
                 361 
                 napevvltdl yspvpenatp ntivavlsvn dqdsgpnrkv slgleatlpf rlngfgnsyt 
               
               
                 421 
                 lvvsgpldre rvavynitvt atdggipqlt slrtlkveis dindnppsfl edsysiyiqe 
               
               
                 481 
                 nnlpgvllct vqatdpdeke naevtyslle reiqglpvts yvsinsasgs lyavnsfdye 
               
               
                 541 
                 kfreffvtve aqdkgsppls stvtanvyvv dmndhaphil yptstnssaa femvprtapa 
               
               
                 601 
                 gylvtkviam dsdsgqnawl fyhlaqtsdl dlfkvelhtg eirttrkmgd esgstfnitv 
               
               
                 661 
                 vvrdngepsl sasvaitvav vdrvskilpd tqrhvksprt yseitlylii alstvsfifl 
               
               
                 721 
                 ltiiilsiik cyrytaygta ccggfcgvre rspaelykqa nnnidariph glkvqphfie 
               
               
                 781 
                 vrgngsltkt ycykacltag sgsdtfmfyn tgaqtgpgps gaqaavtdsr nitgqsgqna 
               
               
                 841 
                 gnliilknea vsqnevrqws ggllqthafv thppiscdla llsh 
               
               
                   
               
               
                 Gene ID: 
                 X20 
               
               
                 Gene symbol: 
                 GPC4 
               
               
                 Gene description: 
                 Glypican 4 
               
               
                 Unigene: 
                 Hs.58367 
               
               
                 Genbank: 
                 AF030186 
               
               
                 Entrez Gene: 
                 2239 
               
               
                 Refseq: 
                 NM_001448 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (43)): 
               
            
           
           
               
               
            
               
                 1 
                 mrllwklvil lplinssagd gllsrpiftq ephdvifpld lsksevilnc aangypsphy 
               
               
                 61 
                 rwkqngtdid ftmsyhyrld ggslainsph tdqdigmyqc latnllgtil srkaklqfay 
               
               
                 121 
                 iedfetktrs tvsvregqgv vllcgppphf gdlsyawtfn dnplyvqedn rrfvsqetgn 
               
               
                 181 
                 lyiakvepsd vgnytcfitn keaqrsvqgp ptplvqrtdg vmgeyepkie vrfpetiqaa 
               
               
                 241 
                 kdssvklecf algnpvpdis wrrldgsplp gkvkysksqa ileipnfqqe degfyecias 
               
               
                 301 
                 nlrgrnlakg qlifyappew eqkiqnthls iydnllweck asgkpnpwyt wlkngerlnp 
               
               
                 361 
                 eeriqiengt liitmlnvsd sgvyqcaaen kyqiiyanae lrvlasapdf skspvkkksf 
               
               
                 421 
                 vqvggdivig ckpnafpraa iswkrgtetl rqskriflle dgslkiynit rsdagsytci 
               
               
                 481 
                 atnqfgtakn tgslivkert vitvppskmd vtvgesivlp cqvshdpsie vvfvwffngd 
               
               
                 541 
                 vidlkkgvah feriggesvg dlmirniqlh hsgkylctvq ttleslsava diivrgppgp 
               
               
                 601 
                 pedvqvedis sttsqlswra gpdnnspiqi ftiqtrtpfs vgwqavatvp eilngktyna 
               
               
                 661 
                 tvvglspwve yefrvvagns igigepseps ellrtkasvp vvapvnihgg ggsrselvit 
               
               
                 721 
                 wesipeelqn gegfgyiimf rpvgsttwsk ekvssvessr fvyrnesiip lspfevkvgv 
               
               
                 781 
                 ynnegegsls tvtivysged epqlaprgts lqsfsaseme vswnaiawnr ntgrvlgyev 
               
               
                 841 
                 lywtddskes migkirvsgn vttknitglk antiyfasvr ayntagtgps sppvnvttkk 
               
               
                 901 
                 sppsqppani awkltnsklc lnwehvktme nesevlgyki lyrqnrqskt hiletnntsa 
               
               
                 961 
                 ellvpfeedy lieirtvsdg gdgssseeir ipkmsslssr giqflepsth flsivivifh 
               
               
                 1021 
                 cfaiqpli 
               
               
                   
               
               
                 Gene ID: 
                 X21 
               
               
                 Gene symbol: 
                 CNTN6 
               
               
                 Gene description: 
                 Contactin 6 
               
               
                 Unigene: 
                 Hs.387300 
               
               
                 Genbank: 
                 AB003592 
               
               
                 Entrez Gene: 
                 27255 
               
               
                 Refseq: 
                 NM_014461 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (44)): 
               
            
           
           
               
               
            
               
                 1 
                 marfglpall ctlavlsaal laaelksksc sevrrlyvsk gfnkndaplh eingdhlkic 
               
               
                 61 
                 pqgstccsqe meekyslqsk ddfksvvseq cnhlqavfas rykkfdeffk ellenaeksl 
               
               
                 121 
                 ndmfvktygh lymqnselfk dlfvelkryy vvgnvnleem lndfwarlle rmfrlvnsqy 
               
               
                 181 
                 hftdeylecv skyteqlkpf gdvprklklq vtrafvaart faqglavagd vvskvsvvnp 
               
               
                 241 
                 taqcthallk miycshcrgl vtvkpcynyc snimrgclan qgdldfewnn fidamlmvae 
               
               
                 301 
                 rlegpfnies vmdpidvkis daimnmqdns vqvsqkvfqg cgppkplpag risrsisesa 
               
               
                 361 
                 fsarfrphhp eerpttaagt sldrlvtdvk eklkqakkfw sslpsnvcnd ermaagngne 
               
               
                 421 
                 ddcwngkgks rylfavtgng lanqgnnpev qvdtskpdil ilrqimalrv mtskmknayn 
               
               
                 481 
                 gndvdffdis dessgegsgs gceyqqcpse fdynatdhag ksanekadsa gvrpgaqayl 
               
               
                 541 
                 ltvfcilflv mqrewr 
               
               
                   
               
               
                 Gene ID: 
                 X22 
               
               
                 Gene symbol: 
                 SLC9A7 
               
               
                 Gene description: 
                 solute carrier family 9 (sodium/hydrogen exchanger), member 7 
               
               
                 Unigene: 
                 Hs.496057 
               
               
                 Genbank: 
                 AF298591 
               
               
                 Entrez Gene: 
                 84679 
               
               
                 Refseq: 
                 NM_001257291 | NM_032591 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (45)): 
               
            
           
           
               
               
            
               
                 1 
                 mepgdaarpg sgratgappp rllllplllg wglrvaaaas asssgaaaed ssameelate 
               
               
                 61 
                 keaeeshrqd syslltfill ltltiltiwl fkhrrvrflh etglamiygl ivgvilrygt 
               
               
                 121 
                 patsgrdksl sctqedrafs tllvnvsgkf feytlkgeis pgkinsveqn dmlrkvtfdp 
               
               
                 181 
                 evffnillpp iifhagyslk krhffrnlgs ilayaflgta vscfiignlm ygvvklmkim 
               
               
                 241 
                 gqlsdkfyyt dclffgaiis atdpvtvlai fnelhadvdl yallfgesvl ndavaivlss 
               
               
                 301 
                 sivayqpagl nthafdaaaf fksvgiflgi fsgsftmgav tgvvtalvtk ftklhcfpll 
               
               
                 361 
                 etalfflmsw stfllaeacg ftgvvavlfc gitqahytyn nlsvesrsrt kqlfevlhfl 
               
               
                 421 
                 aenfifsymg lalftfqkhv fspifiigaf vaiflgraah iyplsfflnl grrhkigwnf 
               
               
                 481 
                 qhmmmfsglr gamafalair dtasyarqmm ftttllivff tvwiigggtt pmlswlnirv 
               
               
                 541 
                 gveepseedq nehhwqyfrv gvdpdqdppp nndsfqvlqg dgpdsargnr tkqesawifr 
               
               
                 601 
                 lwysfdhnyl kpilthsgpp ltttlpawcg llarcltspq vydnqeplre edsdfilteg 
               
               
                 661 
                 dltltygdst vtangssssh tastslegsr rtkssseevl erdlgmgdqk vssrgtrlvf 
               
               
                 721 
                 pledna 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (46)): 
               
            
           
           
               
               
            
               
                 1 
                 mepgdaarpg sgratgappp rllllplllg wglrvaaaas asssgaaaed ssameelate 
               
               
                 61 
                 keaeeshrqd syslltfill ltltiltiwl fkhrrvrflh etglamiygl ivgvilrygt 
               
               
                 121 
                 patsgrdksl sctqedrafs tllvnvsgkf feytlkgeis pgkinsveqn dmlrkvtfdp 
               
               
                 181 
                 evffnillpp iifhagyslk krhffrnlgs ilayaflgta vscffignlm ygvvklmkim 
               
               
                 241 
                 gqlsdkfyyt dclffgaiis atdpvtvlai fnelhadvdl yallfgesvl ndavaivlss 
               
               
                 301 
                 sivayqpagl nthafdaaaf fksvgiflgi fsgsftmgav tgvnanvtkf tklhcfplle 
               
               
                 361 
                 talfflmsws tfllaeacgf tgvvavlfcg itqahytynn lsvesrsrtk qlfevlhfla 
               
               
                 421 
                 enfifsymgl alftfqkhvf spifiigafv aiflgraahi yplsfflnlg rrhkigwnfq 
               
               
                 481 
                 hmmmfsglrg amafalaird tasyarqmmf tttllivfft vwiigggttp mlswlnirvg 
               
               
                 541 
                 veepseedqn ehhwqyfrvg vdpdqdpppn ndsfqvlqgd gpdsargnrt kqesawifrl 
               
               
                 601 
                 wysfdhnylk pilthsgppl tttlpawcgl larcltspqv ydnqeplree dsdfiltegd 
               
               
                 661 
                 ltltygdstv tangssssht astslegsrr tkssseevle rdlgmgdqkv ssrgtrlvfp 
               
               
                 721 
                 ledna 
               
               
                   
               
               
                 Gene ID: 
                 X23 
               
               
                 Gene symbol: 
                 PVRL3 
               
               
                 Gene description: 
                 poliovirus receptor-related 3 
               
               
                 Unigene: 
                 Hs.293917 
               
               
                 Genbank: 
                 AK075105 
               
               
                 Entrez Gene: 
                 25945 
               
               
                 Refseq: 
                 NM_015480 | NM_001243286 | NM_001243288 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (47)): 
               
            
           
           
               
               
            
               
                 1 
                 martlrpspl cpgggkaqls sasllgagll lqpptpppll lllfplllfs rlcgalagpi 
               
               
                 61 
                 ivephvtavw gknvslkcli evnetitqis wekihgkssq tvavhhpqyg fsvqgeyqgr 
               
               
                 121 
                 vlfknyslnd atitlhnigf sdsgkyicka vtfplgnaqs sttvtvlvep tvslikgpds 
               
               
                 181 
                 lidggnetva aiciaatgkp vahidwegdl gemestttsf pnetatiisq yklfptrfar 
               
               
                 241 
                 grritcvvkh palekdirys fildiqyape vsvtgydgnw fvgrkgvnlk cnadanpppf 
               
               
                 301 
                 ksvwsrldgq wpdgllasdn tlhfvhpltf nysgvyickv tnslgqrsdq kviyisdppt 
               
               
                 361 
                 tttlqptiqw hpstadiedl atepkklpfp lstlatikdd tiatiiasvv ggalfivlvs 
               
               
                 421 
                 vlagifcyrr rrtfrgdyfa knyippsdmq kesqidvlqq deldsypdsv kkenknpvnn 
               
               
                 481 
                 lirkdyleep ektqwnnven lnrferpmdy yedlkmgmkf vsdehydene ddlvshvdgs 
               
               
                 541 
                 visrrewyv 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (48)): 
               
            
           
           
               
               
            
               
                 1 
                 martlrpspl cpgggkaqls sasllgagll lqpptpppll lllfplllfs rlcgalagpi 
               
               
                 61 
                 ivephvtavw gknvslkcli evnetitqis wekihgkssq tvavhhpqyg fsvqgeyqgr 
               
               
                 121 
                 vlfknyslnd atitlhnigf sdsgkyicka vtfplgnaqs sttvtvlvep tvslikgpds 
               
               
                 181 
                 lidggnetva aiciaatgkp vahidwegdl gemestttsf pnetatiisq yklfptrfar 
               
               
                 241 
                 grritcvvkh palekdirys fildiqyape vsvtgydgnw fvgrkgvnik cnadanpppf 
               
               
                 301 
                 ksvwsrldgq wpdgilasdn tlhfvhpltf nysgvyickv tnslgqrsdq kviyisayns 
               
               
                 361 
                 vaslnc 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 3 (SEQ ID NO (49)): 
               
            
           
           
               
               
            
               
                 1 
                 maegwrwcfv rrtpgllrgp llprsfsgnp ralagpiive phvtavwgkn vslkclievn 
               
               
                 61 
                 etitqiswek ihgkssqtva vhhpqygfsv qgeyqgrvlf knyslndati tlhnigfsds 
               
               
                 121 
                 gkyickavtf plgnaqsstt vtvlveptvs likgpdslid ggnetvaaic iaatgkpvah 
               
               
                 181 
                 idwegdlgem estttsfpne tatiisqykl fptrfargrr itcvvkhpal ekdirysfil 
               
               
                 241 
                 diqyapevsv tgydgnwfvg rkgvnlkcna danpppfksv wsrldgqwpd gllasdntlh 
               
               
                 301 
                 fvhpltfnys gvyickvtns lgqrsdqkvi yisdvpfkqt ssiavagavi gavlalfiia 
               
               
                 361 
                 ifvtvlltpr kkrpsyldkv idlppthkpp plyeersppl pqkdlfqpeh lplqtqfker 
               
               
                 421 
                 evgnlqhsng lnsrsfdyed enpvgedgiq qmyplynqmc yqdrspgkhh qnndpkrvyi 
               
               
                 481 
                 dprehyv 
               
               
                   
               
               
                 Gene ID: 
                 X24 
               
               
                 Gene symbol: 
                 SLC4A4 
               
               
                 Gene description: 
                 solute carrier family 4, sodium bicarbonate cotransporter, member 4 
               
               
                 Unigene: 
                 Hs.5462 
               
               
                 Genbank: 
                 AF011390 
               
               
                 Entrez Gene: 
                 8671 
               
               
                 Refseq: 
                 NM_001098484 | NM_001134742 | NM_003759 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (50)): 
               
            
           
           
               
               
            
               
                 1 
                 medeavldrg asflkhvcde eeveghhtiy igvhvpksyr rrrrhkrktg hkekkekeri 
               
               
                 61 
                 senysdksdi enadessssi lkplispaae rirfilgeed dspappqlft eldellavdg 
               
               
                 121 
                 qemewketar wikfeekveq ggerwskphv atlslhslfe lrtcmekgsi mldreasslp 
               
               
                 181 
                 qlvemivdhq ietgllkpel kdkvtytllr khrhqtkksn lrsladigkt vssasrmftn 
               
               
                 241 
                 pdngspamth rnltssslnd isdkpekdql knkfmkklpr daeasnvlvg evdfldtpfi 
               
               
                 301 
                 afvrlqqavm lgaltevpvp trfifillgp kgkaksyhei graiatlmsd evfhdiayka 
               
               
                 361 
                 kdrhdliagi defldevivl ppgewdpair ieppkslpss dkrknmysgg envqmngdtp 
               
               
                 421 
                 hdgghggggh gdceelqrtg rfcgglikdi krkapffasd fydalniqal sailfiylat 
               
               
                 481 
                 vtnaitfggl lgdatdnmqg vlesflgtav sgaifclfag qpltilsstg pvlvferlif 
               
               
                 541 
                 nfskdnnfdy lefriwiglw saficlilva tdasflvqyf trfteegfss lisfifiyda 
               
               
                 601 
                 fkkmiklady ypinsnfkvg yntlfsctcv ppdpanisis ndttlapeyl ptmsstdmyh 
               
               
                 661 
                 nttfdwafls kkecskyggn lvgnnenfvp ditlmsfilf lgtytssmal kkfktspyfp 
               
               
                 721 
                 ttarklisdf aiilsilifc vidalvgvdt pklivpsefk ptspnrgwfv ppfgenpwwv 
               
               
                 781 
                 claaaipall vtilifmdqq itavivnrke hklkkgagyh ldlfwvailm vicslmalpw 
               
               
                 841 
                 yvaatvisia hidslkmete tsapgeqpkf lgvreqrvtg tlvfiltgls vfmapilkfi 
               
               
                 901 
                 pmpvlygvfl ymgvaslngv qfmdrlklll mplkhqpdfi ylrhyplrrv hlftflqvlc 
               
               
                 961 
                 lallwilkst vaaiifpvmi lalvavrkgm dylfsqhdls flddvipekd kkkkedekkk 
               
               
                 1021 
                 kkkkgsldsd nddsdcpyse kvpsikipmd imeqqpflsd skpsdrersp tflerhtsc 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 3 (SEQ ID NO (51)): 
               
            
           
           
               
               
            
               
                 1 
                 medeavldrg asflkhvcde eeveghhtiy igvhvpksyr rrrrhkrktg hkekkekeri 
               
               
                 61 
                 senysdksdi enadessssi lkplispaae rirfilgeed dspappqlft eldellavdg 
               
               
                 121 
                 qemewketar wikfeekveq ggerwskphv atlslhslfe lrtcmekgsi mldreasslp 
               
               
                 181 
                 qlvemivdhq ietgllkpel kdkvtytllr khrhqtkksn lrsladigkt vssasrmftn 
               
               
                 241 
                 pdngspamth rnltssslnd isdkpekdql knkfmkklpr daeasnvlvg evdfldtpfi 
               
               
                 301 
                 afvrlqqavm lgaltevpvp trflfillgp kgkaksyhei graiatlmsd evfhdiayka 
               
               
                 361 
                 kdrhdliagi defidevivi ppgewdpair ieppkslpss dkrknmysgg envqmngdtp 
               
               
                 421 
                 hdgghggggh gdceelqrtg rfcgglikdi krkapffasd fydalniqal sailfiylat 
               
               
                 481 
                 vtnaitfggl lgdatdnmqg vlesflgtav sgaifclfag qpltilsstg pvlvferllf 
               
               
                 541 
                 nfskdnnfdy lefrlwiglw saflclilva tdasflvqyf trfteegfss lisfifiyda 
               
               
                 601 
                 fkkmiklady ypinsnfkvg yntlfsctcv ppdpanisis ndttlapeyl ptmsstdmyh 
               
               
                 661 
                 nttfdwafls kkecskyggn lvgnnenfvp ditlmsfilf lgtytssmal kkfktspyfp 
               
               
                 721 
                 ttarklisdf aiilsilifc vidalvgvdt pklivpsefk ptspnrgwfv ppfgenpwwv 
               
               
                 781 
                 claaaipall vtilifmdqq itavivnrke hklkkgagyh ldlfwvailm vicslmalpw 
               
               
                 841 
                 yvaatvisia hidslkmete tsapgeqpkf lgvreqrvtg tlvfiltgls vfmapilkfi 
               
               
                 901 
                 pmpvlygvfl ymgvaslngv qfmdrlklll mplkhqpdfi ylrhyplrrn hlftflqvlc 
               
               
                 961 
                 lallwilkst vaaiifpvmi lalvavrkgm dylfsqhdls flddvipekd kkkkedekkk 
               
               
                 1021 
                 kkkkgsldsd nddekdhqhs lnathhadki pflqsigmps pprtpvkvvp qirieleped 
               
               
                 1081 
                 ndyfwrskgt ettl 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (52)): 
               
            
           
           
               
               
            
               
                 1 
                 mstenvegkp snlgergrar sstflrvvqp mfnhsiftsa vspaaerirf ilgeeddspa 
               
               
                 61 
                 ppqlftelde llavdgqeme wketarwikf eekveqgger wskphvatls lhslfelrtc 
               
               
                 121 
                 mekgsimldr easslpqlve mivdhqietg llkpelkdkv tytllrkhrh qtkksnlrsl 
               
               
                 181 
                 adigktvssa srmftnpdng spamthrnlt ssslndisdk pekdqlknkf mkklprdaea 
               
               
                 241 
                 snvlvgevdf ldtpfiafvr lqqavmlgal tevpvptrfl fillgpkgka ksyheigrai 
               
               
                 301 
                 atlmsdevfh diaykakdrh dliagidefl devivlppge wdpairiepp kslpssdkrk 
               
               
                 361 
                 nmysggenvq mngdtphdgg hgggghgdce elqrtgrfcg glikdikrka pffasdfyda 
               
               
                 421 
                 lniqalsail fiylatvtna itfggllgda tdnmqgvles flgtaysgai fclfagqplt 
               
               
                 481 
                 ilsstgpvlv ferllfnfsk dnnfdylefr lwiglwsafl clilvatdas flvqyftrft 
               
               
                 541 
                 eegfsslisf ifiydafkkm ikladyypin snfkvgyntl fsctcvppdp anisisndtt 
               
               
                 601 
                 lapeyiptms stdmyhnttf dwaflskkec skyggnlvgn nenfvpditl msfilflgty 
               
               
                 661 
                 tssmalkkfk tspyfpttar klisdfaiil silifcvida lvgvdtpkli vpsefkptsp 
               
               
                 721 
                 nrgwfvppfg enpwwvclaa aipallvtil ifmdqqitav ivnrkehklk kgagyhldlf 
               
               
                 781 
                 wvailmvics lmalpwyvaa tvisiahids lkmetetsap geqpkflgvr eqrvtgtlvf 
               
               
                 841 
                 iltglsvfma pilkfipmpv lygvflymgv aslngvqfmd rlklllmplk hqpdfiylrh 
               
               
                 901 
                 vplrrvhlft flqvlclall wilkstvaai ifpvmilalv avrkgmdylf sqhdlsfldd 
               
               
                 961 
                 vipekdkkkk edekkkkkkk gsldsdndds dcpysekvps ikipmdimeq qpflsdskps 
               
               
                 1021 
                 drersptfle rhtsc 
               
               
                   
               
               
                 Gene ID: 
                 X25 
               
               
                 Gene symbol: 
                 CXADR 
               
               
                 Gene description: 
                 coxsackie virus and adenovirus receptor 
               
               
                 Unigene: 
                 Hs.634837 
               
               
                 Genbank: 
                 AY072912 | AY072911 | AY072910 | AK313526 | 
               
               
                 Entrez Gene: 
                 1525 
               
               
                 Refseq: 
                 NM_001338 | NM_001207063 | NM_001207064 | NM_001207065 | 
               
               
                   
                 NM_001207066 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (53)): 
               
            
           
           
               
               
            
               
                 1 
                 malllcfvll cgvvdfarsl sittpeemie kakgetaylp ckftlspedq gpldiewlis 
               
               
                 61 
                 padnqkvdqv iilysgdkiy ddyypdlkgr vhftsndlks gdasinvtnl qlsdigtyqc 
               
               
                 121 
                 kvkkapgvan kkihlvvlvk psgarcyvdg seeigsdfki kcepkegslp lqyewqklsd 
               
               
                 181 
                 sqkmptswla emtssvisvk nasseysgty sctvrnrvgs dqcllrlnvv ppsnkaglia 
               
               
                 241 
                 gaiigtllal aligliifcc rkkrreekye kevhhdired vpppksrtst arsyigsnhs 
               
               
                 301 
                 slgsmspsnm egysktqynq vpsedfertp qsptlppakv aapnlsrmga ipvmipaqsk 
               
               
                 361 
                 dgsiv 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (54)): 
               
            
           
           
               
               
            
               
                 1 
                 malllcfvll cgvvdfarsl sittpeemie kakgetaylp ckftlspedq gpldiewlis 
               
               
                 61 
                 padnqkvdqv iilysgdkiy ddyypdlkgr vhftsndlks gdasinvtnl qlsdigtyqc 
               
               
                 121 
                 kvkkapgvan kkihlvvlvk psgarcyvdg seeigsdfki kcepkegslp lqyewqklsd 
               
               
                 181 
                 sqkmptswla gkmchlqrav rplpeatsav iihpwgpcll ptwkdiprls itkyqvktln 
               
               
                 241 
                 allrvrlshl lr 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 3 (SEQ ID NO(55)): 
               
            
           
           
               
               
            
               
                 1 
                 malllcfvll cgvvdfarsl sittpeemie kakgetaylp ckftlspedq gpldiewlis 
               
               
                 61 
                 padnqkvdqv iilysgdkiy ddyypdlkgr vhftsndlks gdasinvtnl qlsdigtyqc 
               
               
                 121 
                 kvkkapgvan kkihlvvlgk mchlqravrp lpeatsavii hpwgpcllpt wkdiprlsit 
               
               
                 181 
                 kyqvktlnal lrvrlshllr 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 4 (SEQ ID NO (56)): 
               
            
           
           
               
               
            
               
                 1 
                 malllcfvll cgnndfarsl sittpeemie kakgetaylp ckftlspedq gpldiewlis 
               
               
                 61 
                 padnqkvdqv grcatskepy vhcqklhrq 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 5 (SEQ ID NO(57)): 
               
            
           
           
               
               
            
               
                 1 
                 malllcfvll cgvvdfarsl sittpeemie kakgetaylp ckftlspedq gpldiewlis 
               
               
                 61 
                 padnqkvdqv iilysgdkiy ddyypdlkgr vhftsndlks gdasinvtnl qlsdigtyqc 
               
               
                 121 
                 kvkkapgvan kkihlvvlvk psgarcyvdg seeigsdfki kcepkegslp lqyewqklsd 
               
               
                 181 
                 sqkmptswla emtssvisvk nasseysgty sctvrnrvgs dqcllrlnvv ppsnkaglia 
               
               
                 241 
                 gaiigtllal aligliifcc rkkrreekye kevhhdired vpppksrtst arsyigsnhs 
               
               
                 301 
                 slgsmspsnm egysktqynq vpsedfertp qsptlppakf kypyktdgit vv 
               
               
                   
               
               
                 Gene ID: 
                 X26 
               
               
                 Gene symbol: 
                 CADM4 
               
               
                 Gene description: 
                 cell adhesion molecule 4 
               
               
                 Unigene: 
                 Hs.370984 
               
               
                 Genbank: 
                 AF363368 
               
               
                 Entrez Gene: 
                 199731 
               
               
                 Refseq: 
                 NM_145296 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (58)): 
               
            
           
           
               
               
            
               
                 1 
                 mgrarrfqwp llllwaaaag pgagqevqte nvtvaeggva eitcrlhqyd gsivviqnpa 
               
               
                 61 
                 rqtlffngtr alkderfqle efsprrvrir lsdarledeg gyfcqlyted thhqiatltv 
               
               
                 121 
                 lvapenpvve vreqavegge velsclvprs rpaatlrwyr drkelkgvss sqengkvwsv 
               
               
                 181 
                 astvrfrvdr kddggiiice aqnqalpsgh skqtqyvldv qysptariha sqavvregdt 
               
               
                 241 
                 lvltcavtgn prpnqirwnr gneslperae avgetltlpg lvsadngtyt ceasnkhgha 
               
               
                 301 
                 ralyvlvvyd pgavveaqts vpyaivggil allvfliicv lvgmvwcsvr qkgsylthea 
               
               
                 361 
                 sgldeqgear eaflngsdgh krkeeffi 
               
               
                   
               
               
                 Gene ID: 
                 Y1 
               
               
                 Gene symbol: 
                 CLCA2 
               
               
                 Gene description: 
                 chloride channel accessory 2 
               
               
                 Unigene: 
                 Hs.241551 
               
               
                 Genbank: 
                 BC041096 
               
               
                 Entrez Gene: 
                 9635 
               
               
                 Refseq: 
                 NM_006536 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (59)): 
               
            
           
           
               
               
            
               
                 1 
                 mtqrsiagpi cnlkfvtllv alsselpflg agvqlqdngy nglliainpq vpenqnlisn 
               
               
                 61 
                 ikemiteasf ylfnatkrrv ffrnikilip atwkannnsk ikqesyekan vivtdwygah 
               
               
                 121 
                 gddpytlqyr gcgkegkyih ftpnfllndn ltagygsrgr vfvhewahlr wgvfdeynnd 
               
               
                 181 
                 kpfyingqnq ikvtrcssdi tgifvcekgp cpqenciisk lfkegctfiy nstqnatasi 
               
               
                 241 
                 mfmqslssvv efcnasthnq eapnlqnqmc slrsawdvit dsadfhhsfp mngtelpppp 
               
               
                 301 
                 tfslvqagdk vvclvldvss kmaeadrllq lqqaaefylm qiveihtfvg iasfdskgei 
               
               
                 361 
                 raqlhqinsn ddrkllvsyl pttvsaktdi sicsglkkgf evveklngka ygsvmilvts 
               
               
                 421 
                 gddkllgncl ptvlssgsti hsialgssaa pnleelsrlt gglkffvpdi snsnsmidaf 
               
               
                 481 
                 srissgtgdi fqqhiqlest genvkphhql kntvtvdntv gndtmflvtw qasgppeiil 
               
               
                 541 
                 fdpdgrkyyt nnfitnitfr taslwipgta kpghwtytln nthhslqalk vtvtsrasns 
               
               
                 601 
                 avppatveaf verdslhfph pvmiyanvkq gfypilnatv tatvepetgd pvtlrllddg 
               
               
                 661 
                 agadvikndg iysryffsfa angryslkvh vnhspsistp ahsipgsham yvpgytangn 
               
               
                 721 
                 iqmnaprksv grneeerkwg fsrvssggsf svlgvpagph pdvfppckii dleavkveee 
               
               
                 781 
                 ltlswtapge dfdqgqatsy eirmskslqn iqddfnnail vntskrnpqq agireififs 
               
               
                 841 
                 pqistngpeh qpngethesh riyvairamd rnslqsaysn iaqaplfipp nsdpvpardy 
               
               
                 901 
                 lilkgvltam gligiiclii wthhtlsrk kradkkengt kll 
               
               
                   
               
               
                 Gene ID: 
                 Y2 
               
               
                 Gene symbol: 
                 ECM1 
               
               
                 Gene description: 
                 extracellular matrix protein 1 
               
               
                 Unigene: 
                 Hs.81071 
               
               
                 Genbank: 
                 U68187 | U68186 | AK097046 
               
               
                 Entrez Gene: 
                 1893 
               
               
                 Refseq: 
                 NM_004425 | NM_022664 | NM_001202858 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (60)): 
               
            
           
           
               
               
            
               
                 1 
                 mgttaraalv ltylavasaa seggftatgq rqlrpehfqe vgyaappspp lsrslpmdhp 
               
               
                 61 
                 dssqhgppfe gqsqvqppps qeatplqqek llpaqlpaek evgpplpqea vplqkelpsl 
               
               
                 121 
                 qhpneqkegt papfgdqshp epeswnaaqh cqqdrsqggw ghrldgfppg rpspdnlnqi 
               
               
                 181 
                 clpnrqhvvy gpwnlpqssy shltrqgetl nfleigysrc chcrshtnrl ecaklvweea 
               
               
                 241 
                 msrfceaefs vktrphwcct rqgearfscf qeeapqphyq lracpshqpd issglelpfp 
               
               
                 301 
                 pgyptldnik nichlrrfrs vprnlpatdp lqrellaliq lerefqrccr qgnnhtctwk 
               
               
                 361 
                 awedtldkyc dreyavkthh hlccrhppsp trdecfarra pypnydrdil tidigrvtpn 
               
               
                 421 
                 lmghlegnqr vltkhkhipg lihnmtarcc dlpfpeqacc aeeekltfin dlcgprrniw 
               
               
                 481 
                 rdpalccyls pgdeqvncfn inylrnvalv sgdtenakgq geqgstggtn isstsepkee 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (61)): 
               
            
           
           
               
               
            
               
                 1 
                 mgttaraalv ltylavasaa seggftatgq rqlrpehfqe vgyaappspp lsrslpmdhp 
               
               
                 61 
                 dssqhgppfe gqsqvqppps qeatplqqek llpaqlpaek evgpplpqea vplqkelpsl 
               
               
                 121 
                 qhpneqkegt papfgdqshp epeswnaaqh cqqdrsqggw ghrldgfppg rpspdnlnqi 
               
               
                 181 
                 clpnrqhvvy gpwnlpqssy shltrqgetl nfleigysrc chcrshtnrl ecaklvwedt 
               
               
                 241 
                 ldkycdreya vkthhhlccr hppsptrdec farrapypny drdiltidig rvtpnlmghl 
               
               
                 301 
                 cgnqrvltkh khipglihnm tarccdlpfp eqaccaeeek ltfindlcgp rrniwrdpal 
               
               
                 361 
                 ccylspgdeq vncfninylr nvalvsgdte nakgqgeqgs tggtnissts epkee 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 3 (SEQ ID NO (62)): 
               
            
           
           
               
               
            
               
                 1 
                 mgttaraalv ltylavasaa seggftatgq rqlrpehfqe vgyaappspp lsrslpmdhp 
               
               
                 61 
                 dssqhgppfe gqsgkegrgp rphsqpwlge rvgcshipps ivqpppsqea tplqqekllp 
               
               
                 121 
                 aqlpaekevg pplpqeavpl qkelpslqhp neqkegtpap fgdqshpepe swnaaqhcqq 
               
               
                 181 
                 drsqggwghr ldgfppgrps pdnlnqiclp nrqhvvygpw nlpqssyshl trqgetlnfl 
               
               
                 241 
                 eigysrcchc rshtnrleca klvweeamsr fceaefsvkt rphwcctrqg earfscfqee 
               
               
                 301 
                 apqphyqlra cpshqpdiss glelpfppgv ptldniknic hlrrfrsvpr nlpatdplqr 
               
               
                 361 
                 ellaliqler efqrccrqgn nhtctwkawe dtldkycdre yavkthhhlc crhppsptrd 
               
               
                 421 
                 ecfarrapyp nydrdiltid igrvtpnlmg hlcgnqrvlt khkhipglih nmtarccdlp 
               
               
                 481 
                 fpeqaccaee ekltfindlc gprrniwrdp alccylspgd eqvncfniny lrnvalvsgd 
               
               
                 541 
                 tenakgqgeq gstggtniss tsepkee 
               
               
                   
               
               
                 Gene ID: 
                 Y3 
               
               
                 Gene symbol: 
                 CLDN1 
               
               
                 Gene description: 
                 claudin 1 
               
               
                 Unigene: 
                 Hs.439060 
               
               
                 Genbank: 
                 AY358652 
               
               
                 Entrez Gene: 
                 9076 
               
               
                 Refseq: 
                 NM_021101 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (63)): 
               
            
           
           
               
               
            
               
                 1 
                 managlqllg filaflgwig aivstalpqw riysyagdni vtaqamyegl wmscvsqstg 
               
               
                 61 
                 qiqckvfdsl lnlsstlqat ralmvvgill gviaifvatv gmkcmkcled devqkmrmav 
               
               
                 121 
                 iggaifflag lailvatawy gnrivqefyd pmtpvnarye fgqalftgwa aaslcllgga 
               
               
                 181 
                 llccscprkt tsyptprpyp kpapssgkdy v 
               
               
                   
               
               
                 Gene ID: 
                 Y4 
               
               
                 Gene symbol: 
                 SFN 
               
               
                 Gene description: 
                 stratifin 
               
               
                 Unigene: 
                 Hs.523718 
               
               
                 Genbank: 
                 AF029082 
               
               
                 Entrez Gene: 
                 2810 
               
               
                 Refseq: 
                 NM_006142 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (64)): 
               
            
           
           
               
               
            
               
                 1 
                 merasliqka klaeqaerye dmaafmkgav ekgeelscee rnllsvaykn vvggqraawr 
               
               
                 61 
                 vlssieqksn eegseekgpe vreyrekvet elqgvcdtvl glldshlike agdaesrvfy 
               
               
                 121 
                 lkmkgdyyry laevatgddk kriidsarsa yqeamdiskk empptnpirl glalnfsvfh 
               
               
                 181 
                 yeianspeea islakttfde amadlhtlse dsykdstlim ql1rdnltlw tadnageegg 
               
               
                 241 
                 eapqepqs 
               
               
                   
               
               
                 Gene ID: 
                 Y5 
               
               
                 Gene symbol: 
                 CD9 
               
               
                 Gene description: 
                 CD9 antigen 
               
               
                 Unigene: 
                 Hs.114286 
               
               
                 Genbank: 
                 AY966455 
               
               
                 Entrez Gene: 
                 928 
               
               
                 Refseq: 
                 NM_001769 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (65)): 
               
            
           
           
               
               
            
               
                 1 
                 mpvkggtkci kyllfgfnfi fwlagiavla iglwlrfdsq tksifeqetn nnnssfytgv 
               
               
                 61 
                 yiligagalm mlvgflgccg avqesqcmlg lffgfllvif aieiaaaiwg yshkdevike 
               
               
                 121 
                 vqefykdtyn klktkdepqr etlkaihyal nccglaggve qfisdicpkk dvletftvks 
               
               
                 181 
                 cpdaikevfd nkfhiigavg igiawmifg mifsmilcca irmremv 
               
               
                   
               
               
                 Gene ID: 
                 Y6 
               
               
                 Gene symbol: 
                 CD109 
               
               
                 Gene description: 
                 CD109 antigen 
               
               
                 Unigene: 
                 Hs.399891 
               
               
                 Genbank: 
                 AF410459 
               
               
                 Entrez Gene: 
                 135228 
               
               
                 Refseq: 
                 NM_133493 | NM_001159587 | NM_001159588 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (66)): 
               
            
           
           
               
               
            
               
                 1 
                 mqgpplltaa hllcvctaal avapgprflv tapgiirpgg nvtigvelle hcpsqvtvka 
               
               
                 61 
                 ellktasnit vsvleaegvf ekgsfktltl pslplnsade iyelrvtgrt qdeilfsnst 
               
               
                 121 
                 rlsfetkris vfiqtdkaly kpkqevkfri vtlfsdfkpy ktslnilikd pksnliqqwl 
               
               
                 181 
                 sqqsdlgvis ktfqlsshpi lgdwsiqvqv ndqtyyqsfq vseyvlpkfe vtlqtplycs 
               
               
                 241 
                 mnskhlngti takytygkpv kgdvtltflp lsfwgkkkni tktfkingsa nfsfndeemk 
               
               
                 301 
                 nvmdssngls eyldlsspgp veilttvtes vtgisrnvst nvffkqhdyi ieffdyttvl 
               
               
                 361 
                 kpslnftatv kvtradgnql tleerrnnvv itvtqrnyte ywsgsnsgnq kmeavqkiny 
               
               
                 421 
                 tvpqsgtfki efpiledsse lqlkayflgs kssmavhslf kspsktyiql ktrdenikvg 
               
               
                 481 
                 spfelvvsgn krlkelsymv vsrgqlvavg kqnstmfslt penswtpkac vivyyieddg 
               
               
                 541 
                 eiisdvlkip vqlvfknkik lywskvkaep sekvslrisv tqpdsivgiv avdksvnlmn 
               
               
                 601 
                 asnditmenv vhelelyntg yylgmfmnsf avfqecglwv ltdanltkdy idgvydnaey 
               
               
                 661 
                 aerfmeeneg hivdihdfsl gssphvrkhf petwiwldtn mgyriyqefe vtvpdsitsw 
               
               
                 721 
                 vatgfvised lglgltttpv elqafqpffi flnlpysvir geefaleiti fnylkdatev 
               
               
                 781 
                 kviieksdkf dilmtsnein atghqqtllv psedgatvlf pirpthlgei pitvtalspt 
               
               
                 841 
                 asdavtqmil vkaegieksy sqsilldltd nrlqstlktl sfsfppntvt gservqitai 
               
               
                 901 
                 gdvlgpsing laslirmpyg cgeqnminfa pniyildylt kkkqltdnlk ekalsfmrqg 
               
               
                 961 
                 yqrellyqre dgsfsafgny dpsgstwlsa fvlrcflead pyididqnvl hrtytwlkgh 
               
               
                 1021 
                 qksngefwdp grvihselqg gnkspvtlta yivtsllgyr kyqpnidvqe sihflesefs 
               
               
                 1081 
                 rgisdnytla lityalssvg spkakealnm ltwraeqegg mqfwvssesk lsdswqprsl 
               
               
                 1141 
                 dievaayall shflqfqtse gipimrwlsr qrnslggfas tqdttvalka lsefaalmnt 
               
               
                 1201 
                 ertniqvtvt gpsspspvkf lidthnrlll qtaelavvqp tavnisangf gfaicqlnvv 
               
               
                 1261 
                 ynvkasgssr rrrsiqnqea fdldvavken kddlnhvdln vctsfsgpgr sgmalmevnl 
               
               
                 1321 
                 lsgfmvpsea islsetvkkv eydhgklnly ldsvnetqfc vnipavrnfk vsntqdasys 
               
               
                 1381 
                 ivdyyeprrq avrsynsevk lsscdlcsdv qgcrpcedga sgshhhssvi fifcfkllyf 
               
               
                 1441 
                 melwl 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (67)): 
               
            
           
           
               
               
            
               
                 1 
                 mqgpplltaa hllcvctaal avapgprflv tapgiirpgg nvtigvelle hcpsqvtvka 
               
               
                 61 
                 ellktasnit vsvleaegvf ekgsfktltl pslplnsade iyelrvtgrt qdeilfsnst 
               
               
                 121 
                 rlsfetkris vfiqtdkaly kpkqevkfri vtlfsdfkpy ktslnilikd pksnliqqwl 
               
               
                 181 
                 sqqsdlgvis ktfqlsshpi lgdwsiqvqv ndqtyyqsfq vseyvlpkfe vtlqtplycs 
               
               
                 241 
                 mnskhlngti takytygkpv kgdvtltflp lsfwgkkkni tktfkingsa nfsfndeemk 
               
               
                 301 
                 nvmdssngls eyldlsspgp veilttvtes vtgisrnvst nvffkqhdyi ieffdyttvl 
               
               
                 361 
                 kpslnftatv kvtradgnql tleerrnnvv itvtqrnyte ywsgsnsgnq kmeavqkiny 
               
               
                 421 
                 tvpqsgtfki efpiledsse lqlkayflgs kssmavhslf kspsktyiql ktrdenikvg 
               
               
                 481 
                 spfelvvsgn krlkelsymv vsrgqlvavg kqnstmfslt penswtpkac vivyyieddg 
               
               
                 541 
                 eiisdvlkip vqlvfknkik lywskvkaep sekvslrisv tqpdsivgiv avdksvnlmn 
               
               
                 601 
                 asnditmenv vhelelyntg yylgmfmnsf avfqecglwv ltdanltkdy idgvydnaey 
               
               
                 661 
                 aerfmeeneg hivdihdfsl gssphyrkhf petwiwldtn mgyriyqefe vtvpdsitsw 
               
               
                 721 
                 vatgfvised lglgltttpv elqafqpffi flnlpysvir geefaleiti fnylkdatev 
               
               
                 781 
                 kviieksdkf dilmtsnein atghqqtllv psedgatvlf pirpthlgei pitvtalspt 
               
               
                 841 
                 asdavtqmil vkaegieksy sqsilldltd nrlqstlktl sfsfppntvt gservqitai 
               
               
                 901 
                 gdvlgpsing laslirmpyg cgeqnminfa pniyildylt kkkqltdnlk ekalsfmrqg 
               
               
                 961 
                 yqrellyqre dgsfsafgny dpsgstwlsa fvlrcflead pyididqnvl hrtytwlkgh 
               
               
                 1021 
                 qksngefwdp grvihselqg gnkspvtlta yivtsllgyr kyqpnidvqe sihflesefs 
               
               
                 1081 
                 rgisdnytla lityalssvg spkakealnm ltwraeqegg mqfwvssesk lsdswqprsl 
               
               
                 1141 
                 dievaayall shflqfqtse gipimrwlsr qrnslggfas tqdttvalka lsefaalmnt 
               
               
                 1201 
                 ertniqvtvt gpsspsplav vqptavnisa ngfgfaicql nvvynvkasg ssrrrrsiqn 
               
               
                 1261 
                 qeafdldvav kenkddlnhv dlnvctsfsg pgrsgmalme vnllsgfmvp seaislsetv 
               
               
                 1321 
                 kkveydhgkl nlyldsvnet qfcvnipavr nfkvsntqda sysivdyyep rrqavrsyns 
               
               
                 1381 
                 evklsscdlc sdvqgcrpce dgasgshhhs svififcfkl lyfmelwl 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 3 (SEQ ID NO (68)): 
               
            
           
           
               
               
            
               
                 1 
                 mqgpplltaa hllcvctaal avapgprflv tapgiirpgg nvtigvelle hcpsqvtvka 
               
               
                 61 
                 ellktasnit vsvleaegvf ekgsfktltl psdpksnliq qwlsqqsdlg viskifqlss 
               
               
                 121 
                 hpilgdwsiq vqvndqtyyq sfqvseyvlp kfevtlqtpl ycsmnskhln gtitakytyg 
               
               
                 181 
                 kpvkgdvtlt flplsfwgkk knitktfkin gsanfsfnde emknvmdssn glseyldlss 
               
               
                 241 
                 pgpveilttv tesvtgisrn vstnvffkqh dyiieffdyt tvlkpslnft atvkvtradg 
               
               
                 301 
                 nqltleerrn nvvitvtqrn yteywsgsns gnqkmeavqk inytvpqsgt fkiefpiled 
               
               
                 361 
                 sselqlkayf lgskssmavh slfkspskty iqlktrdeni kvgspfelvv sgnkrlkels 
               
               
                 421 
                 ymvvsrgqlv avgkqnstmf sltpenswtp kacvivyyie ddgeiisdvl kipvqlvfkn 
               
               
                 481 
                 kiklywskvk aepsekvslr isvtqpdsiv givavdksvn lmnasnditm envvhelely 
               
               
                 541 
                 ntgyylgmfm nsfavfqecg lwvltdanlt kdyidgvydn aeyaerfmee neghivdihd 
               
               
                 601 
                 fslgssphyr khfpetwiwl dtnmgyriyq efevtvpdsi tswvatgfvi sedlglgltt 
               
               
                 661 
                 tpvelqafqp ffiflnlpys virgeefale itifnylkda tevkviieks dkfdilmtsn 
               
               
                 721 
                 einatghqqt llvpsedgat vlfpirpthl geipitvtal sptasdavtq milvkaegie 
               
               
                 781 
                 ksysqsilld ltdnrlqstl ktlsfsfppn tvtgservqi taigdvlgps inglaslirm 
               
               
                 841 
                 pygcgeqnmi nfapniyild yltkkkqltd nlkekalsfm rqgyqrelly qredgsfsaf 
               
               
                 901 
                 gnydpsgstw lsafvlrcfl eadpyididq nvlhrtytwl kghqksngef wdpgrvihse 
               
               
                 961 
                 lqggnkspvt ltayivtsll gyrkyqpnid vqesihfles efsrgisdny tlalityals 
               
               
                 1021 
                 svgspkakea lnmltwraeq eggmqfwvss esklsdswqp rsldievaay allshflqfq 
               
               
                 1081 
                 tsegipimrw lsrqrnslgg fastqdttva lkalsefaal mntertniqv tvtgpsspsp 
               
               
                 1141 
                 vkflidthnr lllqtaelav vqptavnisa ngfgfaicql nvvynvkasg ssrrrrsiqn 
               
               
                 1201 
                 qeafdldvav kenkddlnhv dlnvctsfsg pgrsgmalme vnllsgfmvp seaislsetv 
               
               
                 1261 
                 kkveydhgkl nlyldsvnet qfcvnipavr nfkvsntqda sysivdyyep rrqavrsyns 
               
               
                 1321 
                 evklsscdlc sdvqgcrpce dgasgshhhs svififcfkl lyfmelwl 
               
               
                   
               
               
                 Gene ID: 
                 Y7 
               
               
                 Gene symbol: 
                 ITGB8 
               
               
                 Gene description: 
                 integrin, beta 8 
               
               
                 Unigene: 
                 Hs.592171 
               
               
                 Genbank: 
                 M73780 
               
               
                 Entrez Gene: 
                 3696 
               
               
                 Refseq: 
                 NM_002214 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (69)): 
               
            
           
           
               
               
            
               
                 1 
                 mcgsalafft aafvclqndr rgpasflwaa wvfslvlglg qgednrcass naascarcla 
               
               
                 61 
                 lgpecgwcvq edfisggsrs ercdivsnli skgcsvdsie ypsvhviipt eneintqvtp 
               
               
                 121 
                 gevsiqlrpg aeanfmlkvh plkkypvdly ylvdvsasmh nnieklnsvg ndlsrkmaff 
               
               
                 181 
                 srdfrlgfgs yvdktvspyi sihperihnq csdynldcmp phgyihvlsl tenitefeka 
               
               
                 241 
                 vhrqkisgni dtpeggfdam lqaavceshi gwrkeakrll lvmtdqtshl aldsklagiv 
               
               
                 301 
                 vpndgnchlk nnvyvksttm ehpslgqlse klidnninvi favqgkqfhw ykdllpllpg 
               
               
                 361 
                 tiageieska anlnnlvvea yqklisevkv qvenqvqgiy fnitaicpdg srkpgmegcr 
               
               
                 421 
                 nvtsndevlf nvtvtmkkcd vtggknyaii kpigfnetak ihihrncscq cednrgpkgk 
               
               
                 481 
                 cvdetfldsk cfqcdenkch fdedqfsses ckshkdqpvc sgrgvcvcgk cschkiklgk 
               
               
                 541 
                 vygkycekdd fscpyhhgnl caghgeceag rcqcfsgweg drcqcpsaaa qhcvnskgqv 
               
               
                 601 
                 csgrgtcvcg rcectdprsi grfcehcptc ytackenwnc mqclhphnls qaildqckts 
               
               
                 661 
                 calmeqqhyv dqtsecfssp sylriffiif ivtfligllk vliirqvilq wnsnkiksss 
               
               
                 721 
                 dyrvsaskkd klilqsvctr avtyrrekpe eikmdiskln ahetfrcnf 
               
               
                   
               
               
                 Gene ID: 
                 Y8 
               
               
                 Gene symbol: 
                 EMP2 
               
               
                 Gene description: 
                 epithelial membrane protein 2 
               
               
                 Unigene: 
                 Hs.531561 
               
               
                 Genbank: 
                 BC009687 
               
               
                 Entrez Gene: 
                 2013 
               
               
                 Refseq: 
                 NM_001424 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (70)): 
               
            
           
           
               
               
            
               
                 1 
                 mlvllaffia fhitsaallf iatvdnawwv gdeffadvwr ictnntnctv indsfqeyst 
               
               
                 61 
                 lqavqatmil stilcciaff ifvlqlfrlk qgerfvltsi iqlmsclcvm iaasiytdrr 
               
               
                 121 
                 edihdknakf ypvtregsyg ysyilawvaf actfisgmmy lilrkrk 
               
               
                   
               
               
                 Gene ID: 
                 Y9 
               
               
                 Gene symbol: 
                 FGFBP1 
               
               
                 Gene description: 
                 fibroblast growth factor binding protein 1 
               
               
                 Unigene: 
                 Hs.1690 
               
               
                 Genbank: 
                 BC008910 
               
               
                 Entrez Gene: 
                 9982 
               
               
                 Refseq: 
                 NM_005130 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (71)): 
               
            
           
           
               
               
            
               
                 1 
                 mkicsltlls flllaaqvll vegkkkvkng lhskvvseqk dtlgntqikq ksrpgnkgkf 
               
               
                 61 
                 vtkdqancrw aateqeegis lkvectqldh efscvfagnp tsclklkder vywkqvarnl 
               
               
                 121 
                 rsqkdicrys ktavktrvcr kdfpesslkl vsstlfgntk prkektemsp rehikgkett 
               
               
                 181 
                 psslavtqtm atkapecved pdmanqrkta lefcgetwss lctfflsivq dtsc 
               
               
                   
               
               
                 Gene ID: 
                 Y10 
               
               
                 Gene symbol: 
                 CDH3 
               
               
                 Gene description: 
                 cad herin 3, type 1, P-cadherin (placental) 
               
               
                 Unigene: 
                 Hs.191842 
               
               
                 Genbank: 
                 BC041846 
               
               
                 Entrez Gene: 
                 1001 
               
               
                 Refseq: 
                 NM_001793 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (72)): 
               
            
           
           
               
               
            
               
                 1 
                 mglprgplas llllqvcwlq caasepcrav freaevtlea ggaeqepgqa lgkvfmgcpg 
               
               
                 61 
                 qepalfstdn ddftvrnget vqerrslker nplkifpskr ilrrhkrdwv vapisvpeng 
               
               
                 121 
                 kgpfpqrinq lksnkdrdtk ifysitgpga dsppegvfav eketgwllln kpldreeiak 
               
               
                 181 
                 yelfghavse ngasvedpmn isiivtdqnd hkpkftqdtf rgsvlegvlp gtsvmqvtat 
               
               
                 241 
                 deddaiytyn gvvaysihsq epkdphdlmf tihrstgtis vissgldrek vpeytltiqa 
               
               
                 301 
                 tdmdgdgstt tavavveild andnapmfdp qkyeahvpen avghevqrlt vtdldapnsp 
               
               
                 361 
                 awratylimg gddgdhftit thpesnqgil ttrkgldfea knqhtlyvev tneapfvlkl 
               
               
                 421 
                 ptstativvh vedvneapvf vppskvvevq egiptgepvc vytaedpdke nqkisyrilr 
               
               
                 481 
                 dpagwlamdp dsgqvtavgt ldredeqfvr nniyevmvla mdngsppttg tgtllltlid 
               
               
                 541 
                 vndhgpvpep rqiticnqsp vrqvlnitdk dlsphtspfq aqltddsdiy wtaevneegd 
               
               
                 601 
                 tvvlslkkfl kqdtydvhls lsdhgnkeql tviratvcdc hghvetcpgp wkggfilpvl 
               
               
                 661 
                 gavlallfll lvllllvrkk rkikeplllp eddtrdnvfy ygeegggeed qdyditqlhr 
               
               
                 721 
                 glearpevvl rndvaptiip tpmyrprpan pdeignfiie nlkaantdpt appydtllvf 
               
               
                 781 
                 dyegsgsdaa slssltssas dqdqdydyln ewgsrfkkla dmygggedd 
               
               
                   
               
               
                 Gene ID: 
                 Y11 
               
               
                 Gene symbol: 
                 ITGB4 
               
               
                 Gene description: 
                 integrin, beta 4 
               
               
                 Unigene: 
                 Hs.632226 
               
               
                 Genbank: 
                 X53587 
               
               
                 Entrez Gene: 
                 3691 
               
               
                 Refseq: 
                 NM_000213 | NM_001005619 | NM_001005731 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (73)): 
               
            
           
           
               
               
            
               
                 1 
                 magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr 
               
               
                 61 
                 cntqaellaa gcqresivvm essfqiteet qidttlrrsq mspqglrvrl rpgeerhfel 
               
               
                 121 
                 evfeplespv dlyilmdfsn smsddldnlk kmgqnlarvl sqltsdytig fgkfvdkvsv 
               
               
                 181 
                 pqtdmrpekl kepwpnsdpp fsfknvislt edvdefrnkl qgerisgnld apeggfdail 
               
               
                 241 
                 qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr 
               
               
                 301 
                 tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle 
               
               
                 361 
                 eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg 
               
               
                 421 
                 thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvcgqcv 
               
               
                 481 
                 csegwsgqtc ncstgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn 
               
               
                 541 
                 fqcprtsgfl cndrgrcsmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr 
               
               
                 601 
                 chchqqslyt dticeinysa ihpglcedlr scvqcqawgt gekkgrtcee cnfkvkmvde 
               
               
                 661 
                 lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll 
               
               
                 721 
                 llpllallll lcwkycacck aclallpccn rghmvgfked hymlrenlma sdhldtpmlr 
               
               
                 781 
                 sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl slrlarlcte nllkpdtrec 
               
               
                 841 
                 aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk 
               
               
                 901 
                 ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql 
               
               
                 961 
                 lveaidvpag tatlgrrlvn itiikeqard vvsfeqpefs vsrgdqvari pvirrvldgg 
               
               
                 1021 
                 ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh 
               
               
                 1081 
                 vqlsnpkfga hlgqphstti iirdpdeldr sftsqmlssq ppphgdlgap qnpnakaags 
               
               
                 1141 
                 rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg 
               
               
                 1201 
                 aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv 
               
               
                 1261 
                 nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp 
               
               
                 1321 
                 krpmsipiip dipivdaqsg edydsflmys ddvlrspsgs qrpsysddtg cgwkfepllg 
               
               
                 1381 
                 eeldlrrytw rlppeliprl sassgrssda eaphgppddg gaggkggslp rsatpgppge 
               
               
                 1441 
                 hlvngrmdfa fpgstnslhr mtttsaaayg thlsphvphr vlstsstltr dynsltrseh 
               
               
                 1501 
                 shsttlprdy stltsysshd srltagvpdt ptrlvfsalg ptslrvswqe prcerplqgy 
               
               
                 1561 
                 sveyqllngg elhrlnipnp aqtsvvvedl lpnhsyvfry raqsqegwgr eregvities 
               
               
                 1621 
                 qvhpqsplcp lpgsaftlst psapgplvft alspdslqls werprrpngd ivgylvtcem 
               
               
                 1681 
                 aqgggpataf rvdgdspesr ltvpglsenv pykfkvqart tegfgpereg iitiesqdgg 
               
               
                 1741 
                 pfpqlgsrag lfqhplqsey ssittthtsa tepflvdglt lgaqhleagg sltrhvtqef 
               
               
                 1801 
                 vsrtlttsgt lsthmdqqff qt 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (74)): 
               
            
           
           
               
               
            
               
                 1 
                 magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr 
               
               
                 61 
                 cntqaellaa gcqresivvm essfqiteet qidttlrrsq mspqglrvil rpgeerhfel 
               
               
                 121 
                 evfeplespv dlyilmdfsn smsddldnlk kmgqnlarvl sqltsdytig fgkfvdkvsv 
               
               
                 181 
                 pqtdmrpekl kepwpnsdpp fsfknvislt edvdefrnkl qgerisgnld apeggfdail 
               
               
                 241 
                 qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr 
               
               
                 301 
                 tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle 
               
               
                 361 
                 eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg 
               
               
                 421 
                 thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvcgqcv 
               
               
                 481 
                 csegwsgqtc ncstgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn 
               
               
                 541 
                 fqcprtsgfl cndrgrcsmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr 
               
               
                 601 
                 chchqqslyt dticeinysa ihpglcedlr scvqcqawgt gekkgrtcee cnfkvkmvde 
               
               
                 661 
                 lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll 
               
               
                 721 
                 llpllallll lcwkycacck aclallpccn rghmvgfked hymlrenlma sdhldtpmlr 
               
               
                 781 
                 sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl slrlarlcte nllkpdtrec 
               
               
                 841 
                 aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk 
               
               
                 901 
                 ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql 
               
               
                 961 
                 lveaidvpag tatlgrrlvn itiikeqard vvsfeqpefs vsrgdqvari pvirrvldgg 
               
               
                 1021 
                 ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh 
               
               
                 1081 
                 vqlsnpkfga hlgqphstti iirdpdeldr sftsqmlssq ppphgdlgap qnpnakaags 
               
               
                 1141 
                 rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg 
               
               
                 1201 
                 aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv 
               
               
                 1261 
                 nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp 
               
               
                 1321 
                 krpmsipiip dipivdaqsg edydsflmys ddvlrspsgs qrpsysddte hlvngrmdfa 
               
               
                 1381 
                 fpgstnslhr mtttsaaayg thlsphvphr vlstsstltr dynsltrseh shsttlprdy 
               
               
                 1441 
                 stltsysshg lppiwehgrs rlplswalgs rsraqmkgfp psrgprdsii lagrpaapsw 
               
               
                 1501 
                 gpdsrltagv pdtptrlvfs algptslrvs wqeprcerpl qgysveyqll nggelhrini 
               
               
                 1561 
                 pnpaqtsvvv edllpnhsyv frvraqsqeg wgreregvit iesqvhpqsp lcplpgsaft 
               
               
                 1621 
                 lstpsapgpl vftalspdsl qlswerprrp ngdivgylvt cemaqgggpa tafrvdgdsp 
               
               
                 1681 
                 esrltvpgls envpykfkvq arttegfgpe regiitiesq dggpfpqlgs raglfqhplq 
               
               
                 1741 
                 seyssittth tsatepflvd gltlgaqhle aggsltrhvt qefvsrtltt sgtlsthmdq 
               
               
                 1801 
                 qffqt 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 3 (SEQ ID NO (75)): 
               
            
           
           
               
               
            
               
                 1 
                 magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr 
               
               
                 61 
                 cntqaellaa gcqresivvm essfqiteet qidttlrrsq mspqglrvrl rpgeerhfel 
               
               
                 121 
                 evfeplespv dlyilmdfsn smsddldnlk kmgqnlarvl sqltsdytig fgkfvdkvsv 
               
               
                 181 
                 pqtdmrpekl kepwpnsdpp fsfknvislt edvdefrnkl qgerisgnld apeggfdail 
               
               
                 241 
                 qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr 
               
               
                 301 
                 tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle 
               
               
                 361 
                 eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg 
               
               
                 421 
                 thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvcgqcv 
               
               
                 481 
                 csegwsgqtc ncstgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn 
               
               
                 541 
                 fqcprtsgfl cndrgrcsmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr 
               
               
                 601 
                 chchqqslyt dticeinysa ihpglcedlr scvqcqawgt gekkgrtcee cnfkvkmvde 
               
               
                 661 
                 lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll 
               
               
                 721 
                 llpllallll lcwkycacck aclallpecn rghmvgfked hymlrenlma sdhldtpmlr 
               
               
                 781 
                 sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl slrlarlcte nllkpdtrec 
               
               
                 841 
                 aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk 
               
               
                 901 
                 ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql 
               
               
                 961 
                 lveaidvpag tatlgrrlvn itiikeqard vvsfeqpefs vsrgdqvari pvirrvldgg 
               
               
                 1021 
                 ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh 
               
               
                 1081 
                 vqlsnpkfga hlgqphstti iirdpdeldr sftsqmlssq ppphgdlgap qnpnakaags 
               
               
                 1141 
                 rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg 
               
               
                 1201 
                 aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv 
               
               
                 1261 
                 nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp 
               
               
                 1321 
                 krpmsipiip dipivdaqsg edydsflmys ddvlrspsgs qrpsysddte hlvngrmdfa 
               
               
                 1381 
                 fpgstnslhr mtttsaaayg thlsphvphr vlstsstltr dynsltrseh shsttlprdy 
               
               
                 1441 
                 stltsvsshd srltagvpdt ptrlvfsalg ptslrvswqe prcerplqgy sveyqllngg 
               
               
                 1501 
                 elhrlnipnp aqtsvvvedl lpnhsyvfrv raqsqegwgr eregvities qvhpqsplcp 
               
               
                 1561 
                 lpgsaftlst psapgplvft alspdslqls werprrpngd ivgylvtcem aqgggpataf 
               
               
                 1621 
                 rvdgdspesr ltvpglsenv pykfkvqart tegfgpereg iitiesqdgg pfpqlgsrag 
               
               
                 1681 
                 lfqhplqsey ssittthtsa tepflvdglt lgaqhleagg sltrhvtqef vsrtlttsgt 
               
               
                 1741 
                 lsthmdqqff qt 
               
               
                   
               
               
                 Gene ID: 
                 Y12 
               
               
                 Gene symbol: 
                 LAMB3 
               
               
                 Gene description: 
                 laminin, beta 3 
               
               
                 Unigene: 
                 Hs.497636 
               
               
                 Genbank: 
                 BC075838 
               
               
                 Entrez Gene: 
                 3914 
               
               
                 Refseq: 
                 NM_000228 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (76)): 
               
            
           
           
               
               
            
               
                 1 
                 mrpffllcfa lpgllhaqqa csrgacyppv gdllvgrtrf lrasstcglt kpetyctqyg 
               
               
                 61 
                 ewqmkcckcd srqphnyysh rvenvasssg pmrwwqsqnd vnpvslqldl drrfqlqevm 
               
               
                 121 
                 mefqgpmpag mlierssdfg ktwrvyqyla adctstfprv rqgrpqswqd vrcqslpqrp 
               
               
                 181 
                 narlnggkvq lnlmdlvsgi patqsqkiqe vgeitnlrvn ftrlapvpqr gyhppsayya 
               
               
                 241 
                 vsqlrlqgsc fchghadrca pkpgasagps tavqvhdvcv cqhntagpnc ercapfynnr 
               
               
                 301 
                 pwrpaegqda hecqrcdcng hsetchfdpa vfaasqgayg gvcdncrdht egkncercql 
               
               
                 361 
                 hyfrnrrpga siqetcisce cdpdgavpga pcdpvtgqcv ckehvqgerc dlckpgftgl 
               
               
                 421 
                 tyanpqgchr cdcnilgsrr dmpcdeesgr clclpnvvgp kcdqcapyhw klasgqgcep 
               
               
                 481 
                 cacdphnsls pqcnqftgqc pcregfgglm csaaairqcp drtygdvatg cracdcdfrg 
               
               
                 541 
                 tegpgcdkas grclcrpglt gprcdqcqrg ycnrypvcva chpcfqtyda dlreqalrfg 
               
               
                 601 
                 rlrnataslw sgpgledrgl asrildaksk ieqiravlss pavteqevaq vasailslrr 
               
               
                 661 
                 tlqglqldlp leeetlslpr dlesldrsfn glltmyqrkr eqfekissad psgafrmlst 
               
               
                 721 
                 ayeqsaqaaq qvsdssrlld qlrdsrreae rlvrqagggg gtgspklval rlemsslpdl 
               
               
                 781 
                 tptfnklcgn srqmactpis cpgelcpqdn gtacgsrcrg vlpraggafl magqvaeqlr 
               
               
                 841 
                 gfnaqlqrtr qmiraaeesa sqiqssaqrl etqvsasrsq meedvrrtrl liqqvrdflt 
               
               
                 901 
                 dpdtdaatiq evseavlalw lptdsatvlq kmneiqaiaa rlpnvdlvls qtkqdiarar 
               
               
                 961 
                 rlqaeaeear srahavegqv edvvgnlrqg tvalqeaqdt mqgtsrslrl iqdrvaevqq 
               
               
                 1021 
                 vlrpaeklvt smtkqlgdfw trmeelrhqa rqqgaeavqa qqlaegaseq alsaqegfer 
               
               
                 1081 
                 ikqkyaelkd rlgqssmlge qgariqsvkt eaeelfgetm emmdrmkdme lellrgsqai 
               
               
                 1141 
                 mlrsadltgl ekrveqirdh ingrvlyyat ck 
               
               
                   
               
               
                 Gene ID: 
                 Y13 
               
               
                 Gene symbol: 
                 CD55 
               
               
                 Gene description: 
                 CD55 antigen 
               
               
                 Unigene: 
                 Hs.126517 
               
               
                 Genbank: 
                 M31516 
               
               
                 Entrez Gene: 
                 1604 
               
               
                 Refseq: 
                 NM_000574 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (77)): 
               
            
           
           
               
               
            
               
                 1 
                 mtvarpsvpa alpllgelpr llllvllclp avwgdcglpp dvpnaqpale grtsfpedtv 
               
               
                 61 
                 itykceesfv kipgekdsvi clkgsqwsdi eefcnrscev ptrlnsaslk qpyitqnyfp 
               
               
                 121 
                 vgtvveyecr pgyrrepsls pkltclqnlk wstavefckk kscpnpgeir ngqidvpggi 
               
               
                 181 
                 lfgatisfsc ntgyklfgst ssfclisgss vqwsdplpec reiycpappq idngiiqger 
               
               
                 241 
                 dhygyrqsvt yacnkgftmi gehsiyctvn ndegewsgpp pecrgkslts kvpptvqkpt 
               
               
                 301 
                 tvnvpttevs ptsqktttkt ttpnaqatrs tpvsrttkhf hettpnkgsg ttsgttrlls 
               
               
                 361 
                 ghtcftltgl lgtlvtmgll t 
               
               
                   
               
               
                 Gene ID: 
                 Y14 
               
               
                 Gene symbol: 
                 CLDN16 
               
               
                 Gene description: 
                 claudin 16 
               
               
                 Unigene: 
                 Hs.251391 
               
               
                 Genbank: 
                 BC069682 
               
               
                 Entrez Gene: 
                 10686 
               
               
                 Refseq: 
                 NM_006580 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (78)): 
               
            
           
           
               
               
            
               
                 1 
                 mtsrtpllvt aclyysycns rhlqqgvrks krpvfshcqv petqktdtrh lsgaragvcp 
               
               
                 61 
                 cchpdgllat mrdllqyiac ffaffsagfl ivatwtdcwm vnaddslevs tkerglwwec 
               
               
                 121 
                 vtnafdgirt cdeydsilae hplklvvtra lmitadilag fgfltlllgl dcvkflpdep 
               
               
                 181 
                 yikvricfva gatlliagtp giigsvwyav dvyverstiv lhniflgiqy kfgwscwlgm 
               
               
                 241 
                 agslgcflag avltcclylf kdvgpernyp yslrkaysaa gvsmaksysa prtetakmya 
               
               
                 301 
                 vdtrv 
               
               
                   
               
               
                 Gene ID: 
                 Y15 
               
               
                 Gene symbol: 
                 LAMA3 
               
               
                 Gene description: 
                 laminin, alpha 3 
               
               
                 Unigene: 
                 Hs.436367 
               
               
                 Genbank: 
                 AY327115 
               
               
                 Entrez Gene: 
                 3909 
               
               
                 Refseq: 
                 NM_198129 | NM_001127717 | NM_000227 | NM_001127718 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (79)): 
               
            
           
           
               
               
            
               
                 1 
                 maaaarprgr algpvlpptp llllvlrvlp acgatardpg aaaglslhpt yfnlaeaari 
               
               
                 61 
                 watatcgerg pgegrpqpel ycklvggpta pgsghtiqgq fcdycnsedp rkahpvtnai 
               
               
                 121 
                 dgserwwqsp plssgtqynr vnltldlgql fhvayilikf ansprpdlwv lersvdfgst 
               
               
                 181 
                 yspwqyfahs kvdclkefgr eanmavtrdd dvlcvteysr ivplengevv vslingrpga 
               
               
                 241 
                 knftfshtlr eftkatnirl rflrtntllg hliskaqrdp tvtrryyysi kdisiggqcv 
               
               
                 301 
                 cnghaevcni nnpeklfrce cqhhtcgetc drcctgynqr rwrpaaweqs heceacnchg 
               
               
                 361 
                 hasncyydpd verqqaslnt qgiyagggvc incqhntagv nceqcakgyt rpygvpvdap 
               
               
                 421 
                 dgcipcscdp ehadgceqgs grchckpnfh gdncekcaig yynfpfclri pifpvstpss 
               
               
                 481 
                 edpvagdikg cdcnlegvlp eicdahgrcl crpgvegprc dtcrsgfysf picqacwcsa 
               
               
                 541 
                 lgsyqmpcss vtgqcecrpg vtgqrcdrcl sgaydfphcq gsssacdpag tinsnlgycq 
               
               
                 601 
                 cklhvegptc srckllywnl dkenpsgcse ckchkagtvs gtgecrqgdg dchckshvgg 
               
               
                 661 
                 dscdtcedgy faleksnyfg cqgcqcdigg alssmcsgps gvcqcrehvv gkvcqrpenn 
               
               
                 721 
                 yyfpdlhhmk yeiedgstpn grdlrfgfdp lafpefswrg yaqmtsvqnd vritlnvgks 
               
               
                 781 
                 sgslfrvilr yvnpgteavs ghitiypswg aaqskeiifl pskepafvtv pgngfadpfs 
               
               
                 841 
                 itpgiwvaci kaegvlldyl vllprdyyea svlqlpvtep cayagppqen cllyqhlpvt 
               
               
                 901 
                 rfpctlacea rhflldgepr pvavrqptpa hpvmvdlsgr evelhlrlri pqvghyvvvv 
               
               
                 961 
                 eysteaaqlf vvdvnvkssg svlagqvniy scnysvlcrs avidhmsria myelladadi 
               
               
                 1021 
                 qlkghmarfl lhqvciipie efsaeyvrpq vhciasygrf vnqsatcvsl ahetpptali 
               
               
                 1081 
                 ldvlsgrpfp hlpqqsspsv dvlpgvtlka pqnqvtlrgr vphlgryvfv ihfyqaahpt 
               
               
                 1141 
                 fpaqvsvdgg wpragsfhas fcphvlgcrd qviaegqief disepevaat vkvpegkslv 
               
               
                 1201 
                 lvrvlvvpae nydyqilhkk smdkslefit ncgknsfyld pqtasrfckn sarslvafyh 
               
               
                 1261 
                 kgalpcechp tgatgphcsp eggqcpcqpn vigrqctrca tghygfprck pcscgrrlce 
               
               
                 1321 
                 emtgqcrcpp rtvrpqcevc ethsfsfhpm agcegcncsr rgtieaampe cdrdsgqcrc 
               
               
                 1381 
                 kpritgrqcd rcasgfyrfp ecvpcncnrd gtepgvcdpg tgaclckenv egtecnvcre 
               
               
                 1441 
                 gsfhldpanl kgctscfcfg vnnqchsshk rrtkfvdmlg whletadrvd ipvsfnpgsn 
               
               
                 1501 
                 smvadlqelp atihsaswva ptsylgdkvs syggyltyqa ksfglpgdmv llekkpdvql 
               
               
                 1561 
                 tgqhmsiiye etntprpdrl hhgrvhvveg nfrhassrap vsreelmtvl srladvriqg 
               
               
                 1621 
                 lyftetqrlt lsevgleeas dtgsgriala veicacppay agdscqgcsp gyyrdhkgly 
               
               
                 1681 
                 tgrcvpcncn ghsnqcqdgs gicvncqhnt agehcercqe gyygnavhgs cracpcphtn 
               
               
                 1741 
                 sfatgcvvng gdvrcsckag ytgtqcerca pgyfgnpqkf ggscqpcscn sngqlgschp 
               
               
                 1801 
                 ltgdcinqep kdsspaeecd dcdscvmtll ndlatmgeql rlyksqlqgl sasaglleqm 
               
               
                 1861 
                 rhmetqakdl rnqllnyrsa isnhgskieg lereltdlnq efetlqekaq vnsrkaqtln 
               
               
                 1921 
                 nnvnratqsa keldvkiknv irnvhillkq isgtdgegnn vpsgdfsrew aeaqrmmrel 
               
               
                 1981 
                 rnrnfgkhlr eaeadkresq lllnrirtwq kthqgenngl ansirdslne yeaklsdlra 
               
               
                 2041 
                 rlqeaaaqak qanglngene ralgaiqrqv keinslqsdf tkylttadss llqtnialql 
               
               
                 2101 
                 meksqkeyek laaslnearq elsdkvrels rsagktslve eaekharslq elakqleeik 
               
               
                 2161 
                 rnasgdelvr cavdaataye nilnaikaae daanraasas esalqtvike dlprkaktls 
               
               
                 2221 
                 snsdkllnea kmtqkklkqe vspalnnlqq tlnivtvqke vidtnlttlr dglhgiqrgd 
               
               
                 2281 
                 idamissaks mvrkanditd evldglnpiq tdverikdty grtqnedfkk altdadnsvn 
               
               
                 2341 
                 kltnklpdlw rkiesinqql lplgnisdnm drireliqqa rdaaskvavp mrfngksgve 
               
               
                 2401 
                 vrlpndledl kgytslslfl qrpnsrengg tenmfvmylg nkdasrdyig mavvdgqltc 
               
               
                 2461 
                 vynlgdreae lqvdqiltks etkeavmdrv kfqriyqfar lnytkgatss kpetpgvydm 
               
               
                 2521 
                 dgrnsntlln ldpenvvfyv ggyppdfklp srlsfppykg cielddlnen vlslynfkkt 
               
               
                 2581 
                 fnlnttevep crrrkeesdk nyfegtgyar vptqphapip tfgqtiqttv drgllffaen 
               
               
                 2641 
                 gdrfislnie dgklmvrykl nselpkergv gdainngrdh siqikigklq krmwinvdvq 
               
               
                 2701 
                 ntiidgevfd fstyylggip iairerfnis tpafrgcmkn lkktsgvvrl ndtvgvtkkc 
               
               
                 2761 
                 sedwklvrsa sfsrggqlsf tdlglpptdh lqasfgfqtf qpsgilldhq twtrnlqvtl 
               
               
                 2821 
                 edgyielsts dsgspifksp qtymdgllhy vsvisdnsgl rlliddqllr nskrlkhiss 
               
               
                 2881 
                 srqslrlggs nfegcisnvf vqrlslspev ldltsnslkr dvslggcsln kppflmllkg 
               
               
                 2941 
                 strfnktktf rinqllqdtp vasprsvkvw qdacsplpkt qanhgalqfg diptshllfk 
               
               
                 3001 
                 lpqellkprs qfavdmqtts srglvfhtgt knsfmalyls kgrlvfalgt dgkklriksk 
               
               
                 3061 
                 ekcndgkwht vvfghdgekg rlvvdglrar egslpgnsti sirapvylgs ppsgkpkslp 
               
               
                 3121 
                 tnsfvgclkn fqldskplyt psssfgvssc lggplekgiy fseegghvvl ahsvllgpef 
               
               
                 3181 
                 klvfsirprs ltgilihigs qpgkhlcvyl eagkvtasmd sgaggtstsv tpkqslcdgq 
               
               
                 3241 
                 whsvavtikq hilhleldtd ssytagqipf ppastqeplh lggapanltt lripvwksff 
               
               
                 3301 
                 gclrnihvnh ipvpvteale vqgpvslngc pdq 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 3 (SEQ ID NO (80)): 
               
            
           
           
               
               
            
               
                 1 
                 maaaarprgr algpvlpptp llllvlrvlp acgatardpg aaaglslhpt yfnlaeaari 
               
               
                 61 
                 watatcgerg pgegrpqpel ycklvggpta pgsghtiqgq fcdycnsedp rkahpvtnai 
               
               
                 121 
                 dgserwwqsp plssgtqynr vnltldlgql fhvayilikf ansprpdlwv lersvdfgst 
               
               
                 181 
                 yspwqyfahs kvdclkefgr eanmavtrdd dvlcvteysr ivplengevv vslingrpga 
               
               
                 241 
                 knftfshtlr eftkatnirl rflrtntllg hliskaqrdp tvtrryyysi kdisiggqcv 
               
               
                 301 
                 cnghaevcni nnpeklfrce cqhhtcgetc drcctgynqr rwrpaaweqs heceacnchg 
               
               
                 361 
                 hasncyydpd verqqaslnt qglyagggvc incqhntagv nceqcakgyy rpygvpvdap 
               
               
                 421 
                 dgcipcscdp ehadgceqgs grchckpnfh gdncekcaig yynfpfclri pifpvstpss 
               
               
                 481 
                 edpvagdikg cdcnlegvlp eicdahgrcl crpgvegprc dtcrsgfysf picqacwcsa 
               
               
                 541 
                 lgsyqmpcss vtgqcecrpg vtgqrcdrcl sgaydfphcq gsssacdpag tinsnlgycq 
               
               
                 601 
                 cklhvegptc srckllywnl dkenpsgcse ckchkagtvs gtgecrqgdg dchckshvgg 
               
               
                 661 
                 dscdtcedgy faleksnyfg cqgcqcdigg alssmcsgps gvcqcrehvv gkvcqrpenn 
               
               
                 721 
                 yyfpdlhhmk yeiedgstpn grdlrfgfdp lafpefswrg yaqmtsvqnd vritlnvgks 
               
               
                 781 
                 sgslfrvilr yvnpgteavs ghitiypswg aaqskeiifl pskepafvtv pgngfadpfs 
               
               
                 841 
                 itpgiwvaci kaegvlldyl vllprdyyea svlqlpvtep cayagppqen cllyqhlpvt 
               
               
                 901 
                 rfpctlacea rhffldgepr pvavrqptpa hpvmvdlsgr evelhlrlri pqvghyvvvv 
               
               
                 961 
                 eysteaaqlf vvdvnvkssg svlagqvniy scnysvlcrs avidhmsria myelladadi 
               
               
                 1021 
                 qlkghmarfl lhqvciipie efsaeyvrpq vhciasygrf vnqsatcvsl ahetpptali 
               
               
                 1081 
                 ldvlsgrpfp hlpqqsspsv dvlpgvtlka pqnqvtlrgr vphlgryvfv ihfyqaahpt 
               
               
                 1141 
                 fpaqvsvdgg wpragsfhas fcphvlgcrd qviaegqief disepevaat vkvpegkslv 
               
               
                 1201 
                 lvrvlvvpae nydyqilhkk smdkslefit ncgknsfyld pqtasrfckn sarslvafyh 
               
               
                 1261 
                 kgalpcechp tgatgphcsp eggqcpcqpn vigrqctrca tghygfprck pcscgrrlce 
               
               
                 1321 
                 emtgqcrcpp rtvrpqcevc ethsfsfhpm agcegcncsr rgtieaampe cdrdsgqcrc 
               
               
                 1381 
                 kpritgrqcd rcasgfyrfp ecvpcncnrd gtepgvcdpg tgaclckenv egtecnvcre 
               
               
                 1441 
                 gsfhldpanl kgctscfcfg vnnqchsshk rrtkfvdmlg whletadrvd ipvsfnpgsn 
               
               
                 1501 
                 smvadlqelp atihsaswva ptsylgdkvs syggyltyqa ksfglpgdmv llekkpdvql 
               
               
                 1561 
                 tgqhmsiiye etntprpdrl hhgrvhvveg nfrhassrap vsreelmtvl srladvriqg 
               
               
                 1621 
                 lyftetqrlt lsevgleeas dtgsgriala veicacppay agdscqgcsp gyyrdhkgly 
               
               
                 1681 
                 tgrcvpcncn ghsnqcqdgs gicvncqhnt agehcercqe gyygnavhgs cracpcphtn 
               
               
                 1741 
                 sfatgcvvng gdvrcsckag ytgtqcerca pgyfgnpqkf ggscqpcscn sngqlgschp 
               
               
                 1801 
                 ltgdcinqep kdsspaeecd dcdscvmtll ndlatmgeql rlvksqlqgl sasaglleqm 
               
               
                 1861 
                 rhmetqakdl rnqllnyrsa isnhgskieg lereltdlnq efetlqekaq vnsrkaqtln 
               
               
                 1921 
                 nnvnratqsa keldvkiknv irnvhmlnri rtwqkthqge nnglansird slneyeakls 
               
               
                 1981 
                 dlrarlqeaa aqakqangln qeneralgai qrqvkeinsl qsdftkyltt adssllqtni 
               
               
                 2041 
                 alqlmeksqk eyeklaasln earqelsdkv relsrsagkt slveeaekha rslqelakql 
               
               
                 2101 
                 eeikrnasgd elvrcavdaa tayenilnai kaaedaanra asasesalqt vikedlprka 
               
               
                 2161 
                 ktlssnsdkl lneakmtqkk lkqevspaln nlqqtlnivt vqkevidtnl ttlrdglhgi 
               
               
                 2221 
                 qrgdidamis saksmvrkan ditdevldgl npiqtdveri kdtygrtqne dfkkaltdad 
               
               
                 2281 
                 nsvnkltnkl pdlwrkiesi nqqllplgni sdnmdrirel iqqardaask vavpmrfngk 
               
               
                 2341 
                 sgvevrlpnd ledlkgytsl slflqrpnsr enggtenmfv mylgnkdasr dyigmavvdg 
               
               
                 2401 
                 qltcvynlgd reaelqvdqi ltksetkeav mdrvkfqriy qfarlnytkg atsskpetpg 
               
               
                 2461 
                 vydmdgrnsn tllnldpenv vfyvggyppd fklpsrlsfp pykgcieldd lnenvlslyn 
               
               
                 2521 
                 fkktfnlntt evepcrrrke esdknyfegt gyarvptqph apiptfgqti qttvdrgllf 
               
               
                 2581 
                 faengdrfis lniedgklmv ryklnselpk ergvgdainn grdhsiqiki gklqkrmwin 
               
               
                 2641 
                 vdvqntiidg evfdfstyyl ggipiairer fnistpafrg cmknlkktsg vvrlndtvgv 
               
               
                 2701 
                 tkkcsedwkl vrsasfsrgg qlsftdlglp ptdhlqasfg fqtfqpsgil ldhqtwtrnl 
               
               
                 2761 
                 qvtledgyie lstsdsgspi fkspqtymdg llhyvsvisd nsglrllidd qllrnskrlk 
               
               
                 2821 
                 hisssrqslr lggsnfegci snvfvqrlsl spevldltsn slkrdvslgg cslnkppflm 
               
               
                 2881 
                 llkgstrfnk tktfrinqll qdtpvasprs vkvwqdacsp lpktqanhga lqfgdiptsh 
               
               
                 2941 
                 llfklpqell kprsqfavdm qttssrglvf htgtknsfma lylskgrlvf algtdgkklr 
               
               
                 3001 
                 ikskekcndg kwhtvvfghd gekgrlvvdg lraregslpg nstisirapv ylgsppsgkp 
               
               
                 3061 
                 kslptnsfvg clknfqldsk plytpsssfg vssclggple kgiyfseegg hvvlahsvll 
               
               
                 3121 
                 gpefklvfsi rprsltgili higsqpgkhl cvyleagkvt asmdsgaggt stsvtpkqsl 
               
               
                 3181 
                 cdgqwhsvav tikqhilhle ldtdssytag qipfppastq eplhlggapa nlttlripvw 
               
               
                 3241 
                 ksffgclrni hvnhipvpvt ealevqgpvs lngcpdq 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (81)): 
               
            
           
           
               
               
            
               
                 1 
                 mppavrrsac smgwlwifga algqclgyss qqqrvpflqp pgqsqlqasy vefrpsqgcs 
               
               
                 61 
                 pgyyrdhkgl ytgrcvpcnc nghsnqcqdg sgicvncqhn tagehcercq egyygnavhg 
               
               
                 121 
                 scracpcpht nsfatgcvvn ggdvrcscka gytgtqcerc apgyfgnpqk fggscqpcsc 
               
               
                 181 
                 nsngqlgsch pltgdcinqe pkdsspaeec ddcdscvmtl lndlatmgeq lrlvksqlqg 
               
               
                 241 
                 lsasaglleq mrhmetqakd lrnqllnyrs aisnhgskie glereltdln qefetlqeka 
               
               
                 301 
                 qvnsrkaqtl nnnvnratqs akeldvkikn virnvhillk qisgtdgegn nvpsgdfsre 
               
               
                 361 
                 waeaqrmmre lrnrnfgkhl reaeadkres qlllnrirtw qkthqgenng lansirdsln 
               
               
                 421 
                 eyeaklsdlr arlqeaaaqa kqanglnqen eralgaiqrq vkeinslqsd ftkylttads 
               
               
                 481 
                 sllqtnialq lmeksqkeye klaaslnear qelsdkvrel srsagktslv eeaekharsl 
               
               
                 541 
                 qelakqleei krnasgdelv rcavdaatay enilnaikaa edaanraasa sesalqtvik 
               
               
                 601 
                 edlprkaktl ssnsdkllne akmtqkklkq evspalnnlq qtlnivtvqk evidtnlttl 
               
               
                 661 
                 rdglhgiqrg didamissak smvrkandit devldglnpi qtdverikdt ygrtqnedfk 
               
               
                 721 
                 kaltdadnsv nkltnklpdl wrkiesinqq llplgnisdn mdrireliqq ardaaskvav 
               
               
                 781 
                 pmrfngksgv evrlpndled lkgytslslf lqrpnsreng gtenmfvmyl gnkdasrdyi 
               
               
                 841 
                 gmavvdgqlt cvynlgdrea elqvdqiltk setkeavmdr vkfqriyqfa rlnytkgats 
               
               
                 901 
                 skpetpgvyd mdgrnsntll nldpenvvfy vggyppdfkl psrlsfppyk gcielddlne 
               
               
                 961 
                 nvlslynfkk tfnlntteve pcrrrkeesd knyfegtgya rvptqphapi ptfgqtiqtt 
               
               
                 1021 
                 vdrgllffae ngdrfislni edgklmvryk lnselpkerg vgdainngrd hsiqikigkl 
               
               
                 1081 
                 qkrmwinvdv qntiidgevf dfstyylggi piairerfni stpafrgcmk nlkktsgvvr 
               
               
                 1141 
                 lndtvgvtkk csedwklvrs asfsrggqls ftdlglpptd hlqasfgfqt fqpsgilldh 
               
               
                 1201 
                 qtwtrnlqvt ledgyielst sdsgspifks pqtymdgllh yvsvisdnsg lrlliddqll 
               
               
                 1261 
                 rnskrlkhis ssrqslrlgg snfegcisnv fvqrlslspe vldltsnslk rdvslggcsl 
               
               
                 1321 
                 nkppflmllk gstrfnktkt frinqllqdt pvasprsvkv wqdacsplpk tqanhgalqf 
               
               
                 1381 
                 gdiptshllf klpqellkpr sqfavdmqtt ssrglvfhtg tknsfmalyl skgrlvfalg 
               
               
                 1441 
                 tdgkklriks kekcndgkwh tvvfghdgek grlvvdglra regslpgnst isirapvylg 
               
               
                 1501 
                 sppsgkpksl ptnsfvgclk nfqldskply tpsssfgvss clggplekgi yfseegghvv 
               
               
                 1561 
                 lahsvllgpe fklvfsirpr sltgilihig sqpgkhlcvy leagkvtasm dsgaggtsts 
               
               
                 1621 
                 vtpkqslcdg qwhsvavtik qhilhleldt dssytagqip fppastqepl hlggapanlt 
               
               
                 1681 
                 tlripvwksf fgclrnihvn hipvpvteal evqgpvslng cpdq 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 4 (SEQ ID NO (82)): 
               
            
           
           
               
               
            
               
                 1 
                 mppavrrsac smgwlwifga algqclgyss qqqrvpflqp pgqsqlqasy vefrpsqgcs 
               
               
                 61 
                 pgyyrdhkgl ytgrcvpcnc nghsnqcqdg sgicvncqhn tagehcercq egyygnavhg 
               
               
                 121 
                 scracpcpht nsfatgcvvn ggdvrcscka gytgtqcerc apgyfgnpqk fggscqpcsc 
               
               
                 181 
                 nsngqlgsch pltgdcinqe pkdsspaeec ddcdscvmtl lndlatmgeq lrlvksqlqg 
               
               
                 241 
                 lsasaglleq mrhmetqakd lrnqllnyrs aisnhgskie glereltdln qefetlqeka 
               
               
                 301 
                 qvnsrkaqtl nnnvnratqs akeldvkikn virnvhmlnr irtwqkthqg ennglansir 
               
               
                 361 
                 dslneyeakl sdlrarlqea aaqakqangl nqeneralga iqrqvkeins lqsdftkylt 
               
               
                 421 
                 tadssllqtn ialqlmeksq keyeklaasl nearqelsdk vrelsrsagk tslveeaekh 
               
               
                 481 
                 arslqelakq leeikrnasg delvrcavda atayenilna ikaaedaanr aasasesalq 
               
               
                 541 
                 tvikedlprk aktlssnsdk llneakmtqk klkqevspal nnlqqtlniv tvqkevidtn 
               
               
                 601 
                 lttlrdglhg iqrgdidami ssaksmvrka nditdevldg lnpiqtdver ikdtygrtqn 
               
               
                 661 
                 edfkkaltda dnsvnkltnk lpdlwrkies inqqllplgn isdnmdrire liqqardaas 
               
               
                 721 
                 kvavpmrfng ksgvevrlpn dledlkgyts lslflqrpns renggtenmf vmylgnkdas 
               
               
                 781 
                 rdyigmavvd gqltcvynlg dreaelqvdq iltksetkea vmdrvkfqri yqfarlnytk 
               
               
                 841 
                 gatsskpetp gvydmdgrns ntllnldpen vvfyvggypp dfklpsrlsf ppykgcield 
               
               
                 901 
                 dlnenvlsly nfkktfnlnt teveperrrk eesdknyfeg tgyarvptqp hapiptfgqt 
               
               
                 961 
                 iqttvdrgll ffaengdrfi slniedgklm vryklnselp kergvgdain ngrdhsiqik 
               
               
                 1021 
                 igklqkrmwi nvdvqntiid gevfdfstyy lggipiaire rfnistpafr gcmknlkkts 
               
               
                 1081 
                 gvvrlndtvg vtkkcsedwk lvrsasfsrg gqlsftdlgl pptdhlqasf gfqtfqpsgi 
               
               
                 1141 
                 lldhqtwtrn lqvtledgyi elstsdsgsp ifkspqtymd gllhyvsvis dnsglrllid 
               
               
                 1201 
                 dqllrmskrl khisssrqsl rlggsnfegc isnvfvqrls lspevldlts nslkrdvslg 
               
               
                 1261 
                 gcslnkppfl mllkgstrfn ktktfrinql lqdtpvaspr svkvwqdacs plpktqanhg 
               
               
                 1321 
                 alqfgdipts hllfklpqel lkprsqfavd mqttssrglv fhtgtknsfm alylskgrlv 
               
               
                 1381 
                 falgtdgkkl rikskekcnd gkwhtvvfgh dgekgrlvvd glraregslp gnstisirap 
               
               
                 1441 
                 vylgsppsgk pkslptnsfy gclknfqlds kplytpsssf gvssclggpl ekgiyfseeg 
               
               
                 1501 
                 ghvvlahsvl lgpefklvfs irprsltgil ihigsqpgkh lcvyleagkv tasmdsgagg 
               
               
                 1561 
                 tstsvtpkqs lcdgqwhsva vtikqhilhl eldtdssyta gqipfppast qeplhlggap 
               
               
                 1621 
                 anlttlripv wksffgclrn ihvnhipvpv tealevqgpv slngcpdq 
               
               
                   
               
               
                 Gene ID: 
                 Y16 
               
               
                 Gene symbol: 
                 CD40 
               
               
                 Gene description: 
                 CD40 molecule 
               
               
                 Unigene: 
                 Hs.472860 
               
               
                 Genbank: 
                 AB209660 
               
               
                 Entrez Gene: 
                 958 
               
               
                 Refseq: 
                 NM_001250 | NM_152854 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (83)): 
               
            
           
           
               
               
            
               
                 1 
                 mvrlplqcvl wgclltavhp epptacrekq ylinsqccsl cqpgqklvsd cteftetecl 
               
               
                 61 
                 pcgesefldt wnrethchqh kycdpnlglr vqqkgtsetd tictceegwh ctseacescv 
               
               
                 121 
                 lhrscspgfg vkqiatgvsd ticepcpvgf fsnvssafek chpwtscetk dlvvqqagtn 
               
               
                 181 
                 ktdvvcgpqd rlralvvipi ifgilfaill vlvfikkvak kptnkaphpk qepqeinfpd 
               
               
                 241 
                 dlpgsntaap vqetlhgcqp vtqedgkesr isvqerq 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (84)): 
               
            
           
           
               
               
            
               
                 1 
                 mvrlplqcvl wgclltavhp epptacrekq ylinsqccsl cqpgqklvsd cteftetecl 
               
               
                 61 
                 pcgesefldt wnrethchqh kycdpnlglr vqqkgtsetd tictceegwh ctseacescv 
               
               
                 121 
                 lhrscspgfg vkqiatgvsd ticepcpvgf fsnvssafek chpwtrspgs aespggdphh 
               
               
                 181 
                 lrdpvchplg aglyqkggqe anq 
               
               
                   
               
               
                 Gene ID: 
                 Y17 
               
               
                 Gene symbol: 
                 COL17A1 
               
               
                 Gene description: 
                 collagen, type XVII, alpha 1 
               
               
                 Unigene: 
                 Hs.117938 
               
               
                 Genbank: 
                 AL138761 
               
               
                 Entrez Gene: 
                 1308 
               
               
                 Refseq: 
                 NM_000494 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (85)): 
               
            
           
           
               
               
            
               
                 1 
                 mdvtkknkrd gtevterivt etvttrltsl ppkggtsngy aktaslgggs rlekqslthg 
               
               
                 61 
                 ssgyinstgs trghastssy rrahspastl pnspgstfer kthvtrhaye gsssgnsspe 
               
               
                 121 
                 yprkefasss trgrsqtres eirvrlqsas pstrwteldd vkrllkgsrs asysptrnss 
               
               
                 181 
                 ntlpipkkgt vetkivtass qsysgtydat ildanlpshv wsstlpagss mgtyhnnmtt 
               
               
                 241 
                 qsssllntna ysagsvfgvp nnmascsptl hpglstsssv fgmqnnlaps lttlshgttt 
               
               
                 301 
                 tstaygvkkn mpqspaavnt gvstsaactt svqsddllhk dckflilekd ntpakkemel 
               
               
                 361 
                 limtkdsgkv ftaspasiaa tsfsedtlkk ekqaaynads glkaeangdl ktvstkgktt 
               
               
                 421 
                 tadihsygss ggggsggggg vggagggpwg papawcpcgs ccswwkwllg llltwllllg 
               
               
                 481 
                 llfglialae evrklkarvd elerirrsil pygdsmdrie kdrlqgmapa agadldkigl 
               
               
                 541 
                 hsdsqeelwm fvrkklmmeq engnlrgspg pkgdmgspgp kgdrgfpgtp gipgplghpg 
               
               
                 601 
                 pqgpkgqkgs vgdpgmegpm gqrgregpmg prgeagppgs gekgergaag epgphgppgv 
               
               
                 661 
                 pgsvgpkgss gspgpqgppg pvglqglrge vglpgvkgdk gpmgppgpkg dqgekgprgl 
               
               
                 721 
                 tgepgmrglp gavgepgakg amgpagpdgh qgprgeqglt gmpgirgppg psgdpgkpgl 
               
               
                 781 
                 tgpqgpqglp gtpgrpgikg epgapgkivt segssmltvp gppgppgamg ppgppgapgp 
               
               
                 841 
                 agpaglpghq evlnlqgppg ppgprgppgp sipgppgprg ppgeglpgpp gppgsflsns 
               
               
                 901 
                 etflsgppgp pgppgpkgdq gppgprghqg eqglpgfsts gsssfglnlq gppgppgpqg 
               
               
                 961 
                 pkgdkgdpgv pgalgipsgp seggssstmy vsgppgppgp pgppgsisss gqeiqqyise 
               
               
                 1021 
                 ymqsdsirsy lsgvqgppgp pgppgpvtti tgetfdysel ashvvsylrt sgygvslfss 
               
               
                 1081 
                 sissedilav lqrddvrqyl rqylmgprgp pgppgasgdg sllsldyael ssrilsymss 
               
               
                 1141 
                 sgisiglpgp pgppglpgts yeellsllrg sefrgivgpp gppgppgipg nvwssisved 
               
               
                 1201 
                 lssylhtagl sfipgppgpp gppgprgppg vsgalatyaa ensdsfrsel isyltspdvr 
               
               
                 1261 
                 sfivgppgpp gpqgppgdsr llstdashsr gssssshsss vrrgssysss mstggggags 
               
               
                 1321 
                 lgaggafgea agdrgpygtd igpgggygaa aeggmyagng gllgadfagd ldynelavry 
               
               
                 1381 
                 sesmqrqgll qgmaytvqgp pgqpgpqgpp giskvfsays nvtadlmdff qtygaiqgpp 
               
               
                 1441 
                 gqkgemgtpg pkgdrgpagp pghpgppgpr ghkgekgdkg dqvyagrrrr rsiavkp 
               
               
                   
               
               
                 Gene ID: 
                 Y18 
               
               
                 Gene symbol: 
                 DSC2 
               
               
                 Gene description: 
                 Desmocollin-2 
               
               
                 Unigene: 
                 Hs.95612 
               
               
                 Genbank: 
                 BC063291 
               
               
                 Entrez Gene: 
                 1824 
               
               
                 Refseq: 
                 NM_024422 | NM_004949 
               
            
           
           
               
            
               
                 Protein sequence isoform Dsc2a (SEQ ID NO (86)): 
               
            
           
           
               
               
            
               
                 1 
                 meaarpsgsw ngalcrllll tlailifasd acknvtlhvp skldaeklvg rvnlkecfta 
               
               
                 61 
                 anlihssdpd fqiledgsvy ttntillsse krsftillsn tenqekkkif vflehqtkvl 
               
               
                 121 
                 kkrhtkekvl rrakrrwapi pcsmlenslg pfplflqqvq sdtaqnytiy ysirgpgvdq 
               
               
                 181 
                 eprnlfyver dtgnlyctrp vdreqyesfe iiafattpdg ytpelplpli ikiedendny 
               
               
                 241 
                 pifteetytf tifencrvgt tvgqvcatdk depdtmhtrl kysiigqvpp sptlfsmhpt 
               
               
                 301 
                 tgvitttssq ldrelidkyq lkikvqdmdg qyfglqttst ciiniddvnd hlptftrtsy 
               
               
                 361 
                 vtsveentvd veilrvtved kdlvntanwr anytilkgne ngnfkivtda ktnegvlcvv 
               
               
                 421 
                 kpinyeekqq milqigvvne apfsreaspr samstatvtv nvedqdegpe cnppiqtvrm 
               
               
                 481 
                 kenaevgtts ngykaydpet rsssgirykk ltdptgwvti dentgsikvf rsldreaeti 
               
               
                 541 
                 kngiynitvl asdqggrtct gtlgiilqdv ndnspfipkk tviickptms saeivavdpd 
               
               
                 601 
                 epihgppfdf slesstsevq rmwrlkaind taarlsyqnd ppfgsyvvpi tvrdrlgmss 
               
               
                 661 
                 vtsldvtlcd citendcthr vdpriggggv qlgkwailai llgiallfci lftlvcgasg 
               
               
                 721 
                 tskqpkvipd dlaqqnlivs nteapgddkv ysangfttqt vgasaqgvcg tvgsglkngg 
               
               
                 781 
                 qetiemvkgg hqtsescrga ghhhtldscr gghtevdncr ytysewhsft qprlgekvyl 
               
               
                 841 
                 cnqdenhkha qdyvltynye grgsvagsvg ccserqeedg lefldnlepk frtlaeacmk 
               
               
                 901 
                 r 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform Dsc2b (SEQ ID NO (87)): 
               
            
           
           
               
               
            
               
                 1 
                 meaarpsgsw ngalcrllll tlailifasd acknvtlhvp skldaeklvg rvnlkecfta 
               
               
                 61 
                 anlihssdpd fqiledgsvy ttntillsse krsftillsn tenqekkkif vflehqtkvl 
               
               
                 121 
                 kkrhtkekvl rrakrrwapi pcsmlenslg pfplflqqvq sdtaqnytiy ysirgpgvdq 
               
               
                 181 
                 eprnlfyver dtgnlyctrp vdreqyesfe iiafattpdg ytpelplpli ikiedendny 
               
               
                 241 
                 pifteetytf tifencrvgt tvgqvcatdk depdtmhtrl kysiigqvpp sptlfsmhpt 
               
               
                 301 
                 tgvitttssq ldrelidkyq lkikvqdmdg qyfglqttst ciiniddvnd hlptftrtsy 
               
               
                 361 
                 vtsveentvd veilrvtved kdlvntanwr anytilkgne ngnfkivtda ktnegvlcvv 
               
               
                 421 
                 kplnyeekqq milqigvvne apfsreaspr samstatvtv nvedqdegpe cnppiqtvrm 
               
               
                 481 
                 kenaevgtts ngykaydpet rsssgirykk ltdptgwvti dentgsikvf rsldreaeti 
               
               
                 541 
                 kngiynitvl asdqggrtct gtlgiilqdv ndnspfipkk tviickptms saeivavdpd 
               
               
                 601 
                 epihgppfdf slesstsevq rmwrlkaind taarlsyqnd ppfgsyvvpi tvrdrlgmss 
               
               
                 661 
                 vtsldvticd citendcthr vdpriggggv qlgkwailai llgiallfci lftlvcgasg 
               
               
                 721 
                 tskqpkvipd dlaqqnlivs nteapgddkv ysangfttqt vgasaqgvcg tvgsgikngg 
               
               
                 781 
                 qetiemvkgg hqtsescrga ghhhtldscr gghtevdncr ytysewhsft qprlgeesir 
               
               
                 841 
                 ghtlikn 
               
               
                   
               
               
                 Gene ID: 
                 Y19 
               
               
                 Gene symbol: 
                 DSC1 
               
               
                 Gene description: 
                 Desmocollin-1 
               
               
                 Unigene: 
                 Hs.567260 
               
               
                 Genbank: 
                 X72925 
               
               
                 Entrez Gene: 
                 1823 
               
               
                 Refseq: 
                 NM_024421lNM_004948 
               
            
           
           
               
            
               
                 Protein sequence isoform Dsc1a (SEQ ID NO (88)): 
               
            
           
           
               
               
            
               
                 1 
                 malasaapgs ifckqllfsl lvltllcdac qkvylrvpsh lqaetlvgkv nleeclksas 
               
               
                 61 
                 lirssdpafr iledgsiytt hdlilsserk sfsiflsdgq rreqqeikvv lsarenkspk 
               
               
                 121 
                 krhtkdtalk rskrrwapip aslmenslgp fpqhvqqiqs daaqnytify sisgpgvdke 
               
               
                 181 
                 pfnlfyiekd tgdifctrsi drekyeqfal ygyattadgy apeyplphii kieddndnap 
               
               
                 241 
                 yfehrvtift vpencrsgts vgkvtatdld epdtlhtrlk ykilqqipdh pkhfsihpdt 
               
               
                 301 
                 gvittttpfl drekcdtyql imevrdmggq pfglfntgti tisledendn ppsftetsyv 
               
               
                 361 
                 teveenridv eilrmkvqdq dlpntphska vykilqgnen gnfiistdpn tnegvlcvvk 
               
               
                 421 
                 plnyevnrqv ilqvgvinea qfskaassqt ptmctttvtv kiidsdegpe chppvkviqs 
               
               
                 481 
                 qdgfpagqel lgykaldpei ssgeglryqk lgdednwfei nqhtgdlrtl kvldreskfv 
               
               
                 541 
                 knnqynisvv avdavgrsct gtlvvhlddy ndhapqidke vticqnnedf avlkpvdpdg 
               
               
                 601 
                 pengppfqff ldnsasknwn ieekdgktai lrqrqnldyn yysvpiqikd rhglvathml 
               
               
                 661 
                 tvrvcdcstp secrmkdkst rdvrpnvilg rwailamvlg svlllcilft cfcvtakrtv 
               
               
                 721 
                 kkcfpediaq qnlivsnteg pgeevteani rlpmqtsnic dtsmsvgtvg gqglktqqsf 
               
               
                 781 
                 emvkggytld snkggghqtl esvkgvgqgd tgryaytdwq sftqprlgek vylcgqdeeh 
               
               
                 841 
                 khcedyvcsy nyegkgslag svgccsdrqe eeglefldhl epkfrtlakt cikk 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform Dsc1b (SEQ ID NO (89)): 
               
            
           
           
               
               
            
               
                 1 
                 malasaapgs ifckqllfsl lvltllcdac qkvylrvpsh lqaetlvgkv nleeclksas 
               
               
                 61 
                 lirssdpafr iledgsiytt hdlilsserk sfsiflsdgq rreqqeikvv lsarenkspk 
               
               
                 121 
                 krhtkdtalk rskrrwapip aslmenslgp fpqhvqqiqs daaqnytify sisgpgvdke 
               
               
                 181 
                 pfnlfyiekd tgdifctrsi drekyeqfal ygyattadgy apeyplplii kieddndnap 
               
               
                 241 
                 yfehrvtift vpencrsgts vgkvtatdld epdtlhtrlk ykilqqipdh pkhfsihpdt 
               
               
                 301 
                 gvittttpfl drekcdtyql imevrdmggq pfglfntgti tisledendn ppsftetsyv 
               
               
                 361 
                 teveenridv eilrmkvqdq dlpntphska vykilqgnen gnfiistdpn tnegvlcvvk 
               
               
                 421 
                 plnyevnrqv ilqvgvinea qfskaassqt ptmctttvtv kiidsdegpe chppvkviqs 
               
               
                 481 
                 qdgfpagqel lgykaldpei ssgeglryqk lgdednwfei nqhtgdlrtl kvldreskfv 
               
               
                 541 
                 knnqynisvv avdavgrsct gtlvvhlddy ndhapqidke vticqnnedf avlkpvdpdg 
               
               
                 601 
                 pengppfqff ldnsasknwn ieekdgktai lrqrqnldyn yysvpiqikd rhglvathml 
               
               
                 661 
                 tvrvcdcstp secrmkdkst rdvrpnvilg rwailamvlg svlllcilft cfcvtakrtv 
               
               
                 721 
                 kkcfpediaq qnlivsnteg pgeevteani rlpmqtsnic dtsmsvgtvg gqgiktqqsf 
               
               
                 781 
                 emvkggytld snkggghqtl esvkgvgqgd tgryaytdwq sftqprlgee sirghtlikn 
               
               
                   
               
               
                 Gene ID: 
                 Y20 
               
               
                 Gene symbol: 
                 ITGA6 
               
               
                 Gene description: 
                 Integrin alpha-6 
               
               
                 Unigene: 
                 Hs.133397 
               
               
                 Genbank: 
                 X59512 
               
               
                 Entrez Gene: 
                 3655 
               
               
                 Refseq: 
                 NM_000210 | NM_001079818 
               
            
           
           
               
            
               
                 Protein sequence isoform b (SEQ ID NO (90)): 
               
            
           
           
               
               
            
               
                 1 
                 maaagqlcll ylsagllsrl gaafnldtre dnvirkygdp gslfgfslam hwqlqpedkr 
               
               
                 61 
                 lllvgaprae alplqranrt gglyscdita rgpctriefd ndadptsesk edqwmgvtvq 
               
               
                 121 
                 sqgpggkvvt cahryekrqh vntkqesrdi fgrcyvlsqn lrieddmdgg dwsfcdgrlr 
               
               
                 181 
                 ghekfgscqq gvaatftkdf hyivfgapgt ynwkgivrve qknntffdmn ifedgpyevg 
               
               
                 241 
                 getehdeslv pvpansylgf sldsgkgivs kdeithtsga pranhsgavv llkrdmksah 
               
               
                 301 
                 llpehifdge glassfgydv avvdlnkdgw qdivigapqy fdrdgevgga vyvymnqqgr 
               
               
                 361 
                 wnnvkpirln gtkdsmfgia vknigdinqd gypdiavgap yddlgkvfiy hgsangintk 
               
               
                 421 
                 ptqvlkgisp yfgysiagnm dldrnsypdv avgslsdsvt ifrsrpvini qktitvtpnr 
               
               
                 481 
                 idlrqktacg apsgiclqvk scfeytanpa gynpsisivg tleaekerrk sglssrvqfr 
               
               
                 541 
                 nqgsepkytq eltlkrqkqk vcmeetlwlq dnirdklrpi pitasveiqe pssrrrvnsl 
               
               
                 601 
                 pevlpilnsd epktahidvh flkegcgddn vensnlkley kfctregnqd kfsylpiqkg 
               
               
                 661 
                 vpelvlkdqk dialeitvtn spsnprnptk dgddaheakl iatfpdtlty sayrelrafp 
               
               
                 721 
                 ekqlscvanq ngsqadcelg npfkrnsnvt fylvlsttev tfdtpdldin lklettsnqd 
               
               
                 781 
                 nlapitakak vvielllsvs gvakpsqvyf ggtvvgeqam ksedevgsli eyefrvinlg 
               
               
                 841 
                 kpltnlgtat lniqwpkeis ngkwllylvk veskglekvt cepqkeinsl nlteshnsrk 
               
               
                 901 
                 kreitekqid dnrkfslfae rkyqtlncsv nvncvnircp lrgldskasl ilrsrlwnst 
               
               
                 961 
                 fleeysklny ldilmrafid vtaaaenirl pnagtqvrvt vfpsktvaqy sgvpwwiilv 
               
               
                 1021 
                 ailagilmla llvfilwkcg ffkrnkkdhy datyhkaeih aqpsdkerlt sda 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform a (SEQ ID NO (91)): 
               
            
           
           
               
               
            
               
                 1 
                 maaagqlcll ylsagllsrl gaafnldtre dnvirkygdp gslfgfslam hwqlqpedkr 
               
               
                 61 
                 lllvgaprae alplqranrt gglyscdita rgpctriefd ndadptsesk edqwmgvtvq 
               
               
                 121 
                 sqgpggkvvt cahryekrqh vntkqesrdi fgrcyvlsqn lrieddmdgg dwsfcdgrlr 
               
               
                 181 
                 ghekfgscqq gvaatftkdf hyivfgapgt ynwkgivrve qknntffdmn ifedgpyevg 
               
               
                 241 
                 getehdeslv pvpansylgf sldsgkgivs kdeitfvsga pranhsgavv llkrdmksah 
               
               
                 301 
                 llpehifdge glassfgydv avvdlnkdgw qdivigapqy fdrdgevgga vyvymnqqgr 
               
               
                 361 
                 wnnvkpirln gtkdsmfgia vknigdinqd gypdiavgap yddlgkvfiy hgsangintk 
               
               
                 421 
                 ptqvlkgisp yfgysiagnm dldrnsypdv avgslsdsvt ifrsrpvini qktitvtpnr 
               
               
                 481 
                 idlrqktacg apsgiclqvk scfeytanpa gynpsisivg tleaekerrk sglssrvqfr 
               
               
                 541 
                 nqgsepkytq eltlkrqkqk vcmeetlwlq dnirdklrpi pitasveiqe pssrrnvnsl 
               
               
                 601 
                 pevlpilnsd epktahidvh flkegcgddn vcnsnlkley kfctregnqd kfsylpiqkg 
               
               
                 661 
                 vpelvlkdqk dialeitvtn spsnprnptk dgddaheakl iatfpdtlty sayrelrafp 
               
               
                 721 
                 ekqlscvanq ngsqadcelg npfkrnsnvt fylvlsttev tfdtpdldin lklettsnqd 
               
               
                 781 
                 nlapitakak vvielllsys gvakpsqvyf ggtvvgeqam ksedevgsli eyefrvinlg 
               
               
                 841 
                 kpltnlgtat lniqwpkeis ngkwllylvk veskglekvt cepqkeinsl nlteshnsrk 
               
               
                 901 
                 kreitekqid dnrkfslfae rkyqtlncsv nvncvnircp lrgldskasl ilrsrlwnst 
               
               
                 961 
                 fleeysklny ldilmrafid vtaaaenirl pnagtqvrvt vfpsktvaqy sgvpwwiilv 
               
               
                 1021 
                 ailagilmla llvfilwkcg ffkrsrydds vpryhavrir keereikdek yidnlekkqw 
               
               
                 1081 
                 itkwnenesy s 
               
               
                   
               
               
                 Gene ID: 
                 Y21 
               
               
                 Gene symbol: 
                 ITGB4 
               
               
                 Gene description: 
                 Integrin beta-4 
               
               
                 Unigene: 
                 Hs.632226 
               
               
                 Genbank: 
                 X53587 | X51841 | X52186 
               
               
                 Entrez Gene: 
                 3691 
               
               
                 Refseq: 
                 NM_000213 | NM_001005619 | NM_001005731 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (92)): 
               
            
           
           
               
               
            
               
                 1 
                 magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr 
               
               
                 61 
                 cntqaellaa gcqresivvm essfqiteet qidttlrrsq mspqglrvrl rpgeerhfel 
               
               
                 121 
                 evfeplespv dlyilmdfsn smsddldnlk kmgqnlarvl sqltsdytig fgkfvdkvsv 
               
               
                 181 
                 pqtdmrpekl kepwpnsdpp fsfknvislt edvdefrnkl qgerisgnld apeggfdail 
               
               
                 241 
                 qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr 
               
               
                 301 
                 tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle 
               
               
                 361 
                 eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg 
               
               
                 421 
                 thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvcgqcv 
               
               
                 481 
                 csegwsgqtc ncstgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn 
               
               
                 541 
                 fqcprtsgfl cndrgrcsmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr 
               
               
                 601 
                 chchqqslyt dticeinysa ihpglcedlr scvqcqawgt gekkgrtcee cnfkvkmvde 
               
               
                 661 
                 lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll 
               
               
                 721 
                 llpllallll lcwkycacck aclallpccn rghmvgfked hymlrenlma sdhldtpmlr 
               
               
                 781 
                 sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl slrlarlcte nllkpdtrec 
               
               
                 841 
                 aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk 
               
               
                 901 
                 ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql 
               
               
                 961 
                 lveaidvpag tatlgrrlvn itiikeqard vvsfeqpefs vsrgdqvari pvirrvldgg 
               
               
                 1021 
                 ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh 
               
               
                 1081 
                 vqlsnpkfga hlgqphstti iirdpdeldr sftsqmlssq ppphgdlgap qnpnakaags 
               
               
                 1141 
                 rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg 
               
               
                 1201 
                 aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv 
               
               
                 1261 
                 nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp 
               
               
                 1321 
                 krpmsipiip dipivdaqsg edydsflmys ddvlrspsgs qrpsvsddtg cgwkfepllg 
               
               
                 1381 
                 eeldlrrvtw rlppeliprl sassgrssda eaphgppddg gaggkggslp rsatpgppge 
               
               
                 1441 
                 hlvngrmdfa fpgstnslhr mtttsaaayg thlsphvphr vlstsstltr dynsltrseh 
               
               
                 1501 
                 shsttlprdy stltsvsshd srltagvpdt ptrlvfsalg ptslrvswqe prcerplqgy 
               
               
                 1561 
                 sveyqllngg elhrlnipnp aqtsvvvedl lpnhsyvfrv raqsqegwgr eregvities 
               
               
                 1621 
                 qvhpqsplcp 1pgsaftlst psapgplvft alspdslqls werprrpngd ivgylvtcem 
               
               
                 1681 
                 aqgggpataf rvdgdspesr ltvpglsenv pykfkvqart tegfgpereg iitiesqdgg 
               
               
                 1741 
                 pfpqlgsrag lfqhplqsey ssittthtsa tepflvdglt lgaqhleagg sltrhvtqef 
               
               
                 1801 
                 vsrtlttsgt lsthmdqqff qt 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (93)): 
               
            
           
           
               
               
            
               
                 1 
                 magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr 
               
               
                 61 
                 cntqaellaa gcqresivvm essfqiteet qidttlrrsq mspqglrvil rpgeerhfel 
               
               
                 121 
                 evfeplespv dlyilmdfsn smsddldnlk kmgqnlarvl sqltsdytig fgkfvdkvsv 
               
               
                 181 
                 pqtdmrpekl kepwpnsdpp fsfknvislt edvdefrnkl qgerisgnld apeggfdail 
               
               
                 241 
                 qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr 
               
               
                 301 
                 tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle 
               
               
                 361 
                 eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg 
               
               
                 421 
                 thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvcgqcv 
               
               
                 481 
                 csegwsgqtc ncstgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn 
               
               
                 541 
                 fqcprtsgfl cndrgrcsmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr 
               
               
                 601 
                 chchqqslyt dticeinysa ihpglcedlr scvqcqawgt gekkgrtcee cnfkvkmvde 
               
               
                 661 
                 lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll 
               
               
                 721 
                 llpllallll lcwkycacck aclallpccn rghmvgfked hymlrenlma sdhldtpmlr 
               
               
                 781 
                 sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl slrlarlcte nllkpdtrec 
               
               
                 841 
                 aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk 
               
               
                 901 
                 ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql 
               
               
                 961 
                 lveaidvpag tatlgrrlvn itiikeqard vvsfeqpefs vsrgdqvari pvirrvldgg 
               
               
                 1021 
                 ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh 
               
               
                 1081 
                 vqlsnpkfga hlgqphstti iirdpdeldr sftsqmlssq ppphgdlgap qnpnakaags 
               
               
                 1141 
                 rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg 
               
               
                 1201 
                 aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv 
               
               
                 1261 
                 nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp 
               
               
                 1321 
                 krpmsipiip dipivdaqsg edydsflmys ddvlrspsgs qrpsvsddte hlvngrmdfa 
               
               
                 1381 
                 fpgstnslhr mtttsaaayg thlsphvphr vlstsstltr dynsltrseh shsttlprdy 
               
               
                 1441 
                 stltsvsshg lppiwehgrs rlplswalgs rsraqmkgfp psrgprdsii lagrpaapsw 
               
               
                 1501 
                 gpdsrltagv pdtptrlvfs algptslrvs wqeprcerpl qgysveyqll nggelhrini 
               
               
                 1561 
                 pnpaqtsvvv edllpnhsyv frvraqsqeg wgreregvit iesqvhpqsp lcplpgsaft 
               
               
                 1621 
                 lstpsapgpl vftalspdsl qlswerprrp ngdivgylvt cemaqgggpa tafrvdgdsp 
               
               
                 1681 
                 esrltvpgls envpykfkvq arttegfgpe regiitiesq dggpfpqlgs raglfqhplq 
               
               
                 1741 
                 seyssittth tsatepflvd gltlgaqhle aggsltrhvt qefvsrtltt sgtlsthmdq 
               
               
                 1801 
                 qffqt 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 3 (SEQ ID NO (94)): 
               
            
           
           
               
               
            
               
                 1 
                 magprpspwa rlllaalisv slsgtlanrc kkapvkscte cvrvdkdcay ctdemfrdrr 
               
               
                 61 
                 cntqaellaa gcqresivvm essfqiteet qidttlrrsq mspqglrvrl rpgeerhfel 
               
               
                 121 
                 evfeplespv dlyilmdfsn smsddldnlk kmgqnlarvl sqltsdytig fgkfvdkvsv 
               
               
                 181 
                 pqtdmrpekl kepwpnsdpp fsfknvislt edvdefrnkl qgerisgnld apeggfdail 
               
               
                 241 
                 qtavctrdig wrpdsthllv fstesafhye adganvlagi msrnderchl dttgtytqyr 
               
               
                 301 
                 tqdypsvptl vrllakhnii pifavtnysy syyeklhtyf pvsslgvlqe dssnivelle 
               
               
                 361 
                 eafnrirsnl diraldsprg lrtevtskmf qktrtgsfhi rrgevgiyqv qlralehvdg 
               
               
                 421 
                 thvcqlpedq kgnihlkpsf sdglkmdagi icdvctcelq kevrsarcsf ngdfvcgqcv 
               
               
                 481 
                 csegwsgqtc ncstgslsdi qpclregedk pcsgrgecqc ghcvcygegr yegqfceydn 
               
               
                 541 
                 fqcprtsgfl cndrgrcsmg qcvcepgwtg pscdcplsna tcidsnggic ngrghcecgr 
               
               
                 601 
                 chchqqslyt dticeinysa ihpglcedlr scvqcqawgt gekkgrtcee cnfkvkmvde 
               
               
                 661 
                 lkraeevvvr csfrdedddc tysytmegdg apgpnstvlv hkkkdcppgs fwwlipllll 
               
               
                 721 
                 llpllallll lcwkycacck aclallpccn rghmvgfked hymlrenlma sdhldtpmlr 
               
               
                 781 
                 sgnlkgrdvv rwkvtnnmqr pgfathaasi nptelvpygl slrlarlcte nllkpdtrec 
               
               
                 841 
                 aqlrqeveen lnevyrqisg vhklqqtkfr qqpnagkkqd htivdtvlma prsakpallk 
               
               
                 901 
                 ltekqveqra fhdlkvapgy ytltadqdar gmvefqegve lvdvrvplfi rpedddekql 
               
               
                 961 
                 lveaidvpag tatlgrrlvn itiikeqard vvsfeqpefs vsrgdqvari pvirrvldgg 
               
               
                 1021 
                 ksqvsyrtqd gtaqgnrdyi pvegellfqp geawkelqvk llelqevdsl lrgrqvrrfh 
               
               
                 1081 
                 vqlsnpkfga hlgqphstti iirdpdeldr sftsqmlssq ppphgdlgap qnpnakaags 
               
               
                 1141 
                 rkihfnwlpp sgkpmgyrvk ywiqgdsese ahlldskvps veltnlypyc dyemkvcayg 
               
               
                 1201 
                 aqgegpyssl vscrthqevp sepgrlafnv vsstvtqlsw aepaetngei tayevcyglv 
               
               
                 1261 
                 nddnrpigpm kkvlvdnpkn rmllienlre sqpyrytvka rngagwgper eaiinlatqp 
               
               
                 1321 
                 krpmsipiip dipivdaqsg edydsflmys ddvlrspsgs qrpsysddte hlvngrmdfa 
               
               
                 1381 
                 fpgstnslhr mtttsaaayg thlsphvphr vlstsstltr dynsltrseh shsttlprdy 
               
               
                 1441 
                 stltsysshd srltagvpdt ptrlvfsalg ptslrvswqe prcerplqgy sveyqllngg 
               
               
                 1501 
                 elhrlnipnp aqtsvvvedl lpnhsyvfrv raqsqegwgr eregvities qvhpqsplcp 
               
               
                 1561 
                 lpgsaftlst psapgplvft alspdslqls werprrpngd ivgylvtcem aqgggpataf 
               
               
                 1621 
                 rvdgdspesr ltvpglsenv pykfkvqart tegfgpereg iitiesqdgg pfpqlgsrag 
               
               
                 1681 
                 lfqhplqsey ssittthtsa tepflvdglt lgaqhleagg sltrhvtqef vsrtlttsgt 
               
               
                 1741 
                 lsthmdqqff qt 
               
               
                   
               
               
                 Gene ID: 
                 Y22 
               
               
                 Gene symbol: 
                 PVRL4 
               
               
                 Gene description: 
                 Poliovirus receptor-related protein 4 
               
               
                 Unigene: 
                 Hs.492490 
               
               
                 Genbank: 
                 BC010423 
               
               
                 Entrez Gene: 
                 81607 
               
               
                 Refseq: 
                 NM_030916 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (95)): 
               
            
           
           
               
               
            
               
                 1 
                 mplslgaemw gpeawlllll llasftgrcp ageletsdvv tvvlgqdakl pcfyrgdsge 
               
               
                 61 
                 qvgqvawarv dagegaqela llhskyglhv spayegrveq pppprnpldg svllrnavqa 
               
               
                 121 
                 degeyecrvs tfpagsfqar lrlrvlvppl pslnpgpale egqgltlaas ctaegspaps 
               
               
                 181 
                 vtwdtevkgt tssrsfkhsr saavtsefhl vpsrsmngqp ltcvvshpgl lqdqrithil 
               
               
                 241 
                 hvsflaeasv rgledqnlwh igregamlkc lsegqpppsy nwtrldgplp sgvrvdgdtl 
               
               
                 301 
                 gfpplttehs giyvchvsne fssrdsqvtv dvldpqedsg kqvdlvsasv vvvgviaall 
               
               
                 361 
                 fcllvvvvvl msryhrrkaq qmtqkyeeel tltrensirr lhshhtdprs qpeesvglra 
               
               
                 421 
                 eghpdslkdn sscsvmseep egrsystltt vreietqtel lspgsgraee eedqdegikq 
               
               
                 481 
                 amnhfvqeng tlrakptgng iyingrghlv 
               
               
                   
               
               
                 Gene ID: 
                 Y23 
               
               
                 Gene symbol: 
                 SDC1 
               
               
                 Gene description: 
                 Syndecan-1 
               
               
                 Unigene: 
                 Hs.224607 
               
               
                 Genbank: 
                 BC008765 
               
               
                 Entrez Gene: 
                 6382 
               
               
                 Refseq: 
                 NM_001006946 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (96)): 
               
            
           
           
               
               
            
               
                 1 
                 mrraalwlwl calalslqpa lpqivatnlp pedqdgsgdd sdnfsgsgag alqditlsqq 
               
               
                 61 
                 tpstwkdtql ltaiptspep tgleataast stlpagegpk egeavvlpev epgltareqe 
               
               
                 121 
                 atprprettq lptthqastt tattaqepat shphrdmqpg hhetstpagp sqadlhtpht 
               
               
                 181 
                 edggpsater aaedgassql paaegsgeqd ftfetsgent avvavepdrr nqspvdqgat 
               
               
                 241 
                 gasqglldrk evlggviagg lvglifavel vgfmlyrmkk kdegsyslee pkqanggayq 
               
               
                 301 
                 kptkqeefya 
               
               
                   
               
               
                 Gene ID: 
                 Z1 
               
               
                 Gene symbol: 
                 ENPP1 
               
               
                 Gene description: 
                 Ectonucleotide pyrophosphatase/ phosphodiesterase family member 1 
               
               
                 Unigene: 
                 Hs.527295 
               
               
                 Genbank: 
                 BC059375 
               
               
                 Entrez Gene: 
                 5167 
               
               
                 Refseq: 
                 NM_006208 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (97)): 
               
            
           
           
               
               
            
               
                 1 
                 merdgcaggg srggeggrap regpagngrd rgrshaaeap gdpqaaasll apmdvgeepl 
               
               
                 61 
                 ekaarartak dpntykvlsl vlsvcvltti lgcifglkps cakevksckg rcfertfgnc 
               
               
                 121 
                 rcdaacvelg nccldyqetc iepehiwtcn kfrcgekrlt rslcacsddc kdkgdcciny 
               
               
                 181 
                 ssvcqgeksw veepcesine pqcpagfetp ptllfsldgf raeylhtwgg llpvisklkk 
               
               
                 241 
                 cgtytknmrp vyptktfpnh ysivtglype shgiidnkmy dpkmnasfsl kskekfnpew 
               
               
                 301 
                 ykgepiwvta kyqglksgtf fwpgsdvein gifpdiykmy ngsvpfeeri lavlqwlqlp 
               
               
                 361 
                 kderphfytl yleepdssgh sygpvssevi kalqrvdgmv gmlmdglkel nlhrclnlil 
               
               
                 421 
                 isdhgmeqgs ckkyiylnky lgdvknikvi ygpaarlrps dvpdkyysfn yegiarnlsc 
               
               
                 481 
                 repnqhfkpy lkhflpkrlh faksdriepl tfyldpqwql alnpserkyc gsgfhgsdnv 
               
               
                 541 
                 fsnmqalfvg ygpgfkhgie adtfenievy nlmcdllnlt papnngthgs lnhllknpvy 
               
               
                 601 
                 tpkhpkevhp lvqcpftrnp rdnlgcscnp silpiedfqt qfnltvaeek iikhetlpyg 
               
               
                 661 
                 rprvlqkent icllsqhqfm sgysqdilmp lwtsytvdrn dsfstedfsn clyqdfripl 
               
               
                 721 
                 spvhkcsfyk nntkvsygfl sppqlnknss giysealltt nivpmyqsfq viwryfhdtl 
               
               
                 781 
                 lrkyaeerng vnvvsgpvfd fdydgrcdsl enlrqkrrvi rnqeilipth ffivltsckd 
               
               
                 841 
                 tsqtplhcen ldtlafilph rtdnsescvh gkhdsswvee llmlhrarit dvehitglsf 
               
               
                 901 
                 yqqrkepvsd ilklkthlpt fsqed 
               
               
                   
               
               
                 Gene ID: 
                 Z2 
               
               
                 Gene symbol: 
                 CD34 
               
               
                 Gene description: 
                 Hematopoietic progenitor cell antigen CD34 
               
               
                 Unigene: 
                 Hs.374990 
               
               
                 Genbank: 
                 M81104 
               
               
                 Entrez Gene: 
                 947 
               
               
                 Refseq: 
                 NM_001773 | NM_001025109 
               
            
           
           
               
            
               
                 Protein sequence isoform b (SEQ ID NO (98)): 
               
            
           
           
               
               
            
               
                 1 
                 mlvrrgarag prmprgwtal cllsllpsgf msldnngtat pelptqgtfs nvstnvsyqe 
               
               
                 61 
                 tttpstlgst slhpvsqhgn eattnitett vkftstsvit svygntnssv qsqtsvistv 
               
               
                 121 
                 fttpanvstp ettlkpslsp gnvsdlstts tslatsptkp ytssspilsd ikaeikcsgi 
               
               
                 181 
                 revkltqgic leqnktssca efkkdrgegl arvlcgeeqa dadagaqvcs lllaqsevrp 
               
               
                 241 
                 qclllvlanr teissklqlm kkhqsdlkkl gildfteqdv ashqsysqkt lialvtsgal 
               
               
                 301 
                 lavlgitgyf lmnrrswspt gerlelep 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform a (SEQ ID NO (99)): 
               
            
           
           
               
               
            
               
                 1 
                 mlvrrgarag prmprgwtal cllsllpsgf msldnngtat pelptqgtfs nvstnvsyqe 
               
               
                 61 
                 tttpstlgst slhpvsqhgn eattnitett vkftstsvit svygntnssv qsqtsvistv 
               
               
                 121 
                 fttpanvstp ettlkpslsp gnvsdlstts tslatsptkp ytssspilsd ikaeikcsgi 
               
               
                 181 
                 revkltqgic leqnktssca efkkdrgegl arvlcgeeqa dadagaqvcs lllaqsevrp 
               
               
                 241 
                 qclllvlanr teissklqlm kkhqsdlkkl gildfteqdv ashqsysqkt lialvtsgal 
               
               
                 301 
                 lavlgitgyf lmnrrswspt gerlgedpyy tengggqgys sgpgtspeaq gkasvnrgaq 
               
               
                 361 
                 engtgqatsr nghsarqhvv adtel 
               
               
                   
               
               
                 Gene ID: 
                 Z3 
               
               
                 Gene symbol: 
                 JAM3 
               
               
                 Gene description: 
                 Junctional adhesion molecule C 
               
               
                 Unigene: 
                 Hs.150718 
               
               
                 Genbank: 
                 BC012147 
               
               
                 Entrez Gene: 
                 83700 
               
               
                 Refseq: 
                 NM_032801 | NM_001205329 
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (100)): 
               
            
           
           
               
               
            
               
                 1 
                 malrrpprlr lcarlpdffl lllfrgclig avnlkssnrt pvvqefesve lsciitdsqt 
               
               
                 61 
                 sdpriewkki qdeqttyvff dnkiqgdlag raeilgktsl kiwnvtrrds alyrcevvar 
               
               
                 121 
                 ndrkeideiv ieltvqvkpv tpvcrvpkav pvgkmatlhc qeseghprph yswyrndvpl 
               
               
                 181 
                 ptdsranprf rnssfhlnse tgtlvftavh kddsgqyyci asndagsarc eeqemevydl 
               
               
                 241 
                 niggiiggvl vvlavlalit lgiccayrrg yfinnkqdge syknpgkpdg vnyirtdeeg 
               
               
                 301 
                 dfrhkssfvi 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (101): 
               
            
           
           
               
               
            
               
                 1 
                 malrrpprlr lcarlpdffl lllfrgclig avnlkssnrt pvvqefesve lsciitdsqt 
               
               
                 61 
                 sdpriewkki qdeqttyvff dnkiqvkpvt pvcrvpkavp vgkmatlhcq eseghprphy 
               
               
                 121 
                 swyrndvplp tdsranprfr nssfhlnset gtlvftavhk ddsgqyycia sndagsarce 
               
               
                 181 
                 eqemevydln iggiiggvlv vlavlalitl giccayrrgy finnkqdges yknpgkpdgv 
               
               
                 241 
                 nyirtdeegd frhkssfvi 
               
               
                   
               
               
                 Gene ID: 
                 Z4 
               
               
                 Gene symbol: 
                 CD14 
               
               
                 Gene description: 
                 Monocyte differentiation antigen CD14 
               
               
                 Unigene: 
                 Hs.163867 
               
               
                 Genbank: 
                 BC010507 
               
               
                 Entrez Gene: 
                 929 
               
               
                 Refseq: 
                 NM_000591 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (102)): 
               
            
           
           
               
               
            
               
                 1 
                 merascllll llplvhvsat tpepceldde dfrcvcnfse pqpdwseafq cvsaveveih 
               
               
                 61 
                 agglnlepfl krvdadadpr qyadtvkalr vrrltvgaaq vpaqllvgal rvlaysrlke 
               
               
                 121 
                 ltledlkitg tmpplpleat glalsslrlr nvswatgrsw laelqqwlkp glkvlsiaqa 
               
               
                 181 
                 hspafsceqv rafpaltsld lsdnpglger glmaalcphk fpaiqnlalr ntgmetptgv 
               
               
                 241 
                 caalaaagvq phsldlshns lratvnpsap rcmwssalns lnlsfagleq vpkglpaklr 
               
               
                 301 
                 vldlscnrln rapqpdelpe vdnltldgnp flvpgtalph egsmnsgvvp acarstlsvg 
               
               
                 361 
                 vsgtlvllqg argfa 
               
               
                   
               
               
                 Gene ID: 
                 Z5 
               
               
                 Gene symbol: 
                 PLSCR4 
               
               
                 Gene description: 
                 Phospholipid scramblase 4 
               
               
                 Unigene: 
                 Hs.477869 
               
               
                 Genbank: 
                 AF199023 
               
               
                 Entrez Gene: 
                 57088 
               
               
                 Refseq: 
                 NM_001128304 | NM_001128306 | NM_001177304 
               
            
           
           
               
            
               
                 Protein sequence isoform a (SEQ ID NO (103)): 
               
            
           
           
               
               
            
               
                 1 
                 msgvvptape qpagemenqt kppdprpdap peynshflpg ppgtavpppt gypgglpmgy 
               
               
                 61 
                 yspqqpstfp lyqpvggihp vryqpgkypm pnqsvpitwm pgptpmancp pgleylvqld 
               
               
                 121 
                 nihvlqhfep lemmtcfetn nrydiknnsd qmvyivtedt ddftrnayrt lrpfvlrvtd 
               
               
                 181 
                 cmgreimtmq rpfrctcccf ccpsarqele vqcppgvtig fvaehwnlcr avysiqnekk 
               
               
                 241 
                 envmrvrgpc stygcgsdsv fevksldgis nigsiirkwn gllsamadad hfdihfpldl 
               
               
                 301 
                 dvkmkamifg acflidfmyf ersppqrsr 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform b (SEQ ID NO (104)): 
               
            
           
           
               
               
            
               
                 1 
                 msgvvptape qpagemenqt kppdprpdap peynshflpg ppgtavpppt gypgglpmgy 
               
               
                 61 
                 yspqqpstfp lyqpvggihp vryqpgkypm pnqsvpitwm pgptpmancp pgleylvqle 
               
               
                 121 
                 vqcppgvtig fvaehwnlcr avysiqnekk envmrvrgpc stygcgsdsv fevksldgis 
               
               
                 181 
                 nigsiirkwn gllsamadad hfdihfpldl dvkmkamifg acflidfmyf ersppqrsr 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform c (SEQ ID NO (105)): 
               
            
           
           
               
               
            
               
                 1 
                 menqtkppdp rpdappeyns hflpgppgta vppptgypgg lpmgyyspqq pstfplyqpv 
               
               
                 61 
                 ggihpvryqp gkypmpnqsv pitwmpgptp mancppgley lvqlevqcpp gvtigfvaeh 
               
               
                 121 
                 wnlcravysi qnekkenvmr vrgpcstygc gsdsvfevks ldgisnigsi irkwngllsa 
               
               
                 181 
                 madadhfdih fpldldvkmk amifgacfli dfmyferspp qrsr 
               
               
                   
               
               
                 Gene ID: 
                 Z6 
               
               
                 Gene symbol: 
                 AMOT 
               
               
                 Gene description: 
                 angiomotin 
               
               
                 Unigene: 
                 Hs.528051 
               
               
                 Genbank: 
                 AF286598 
               
               
                 Entrez Gene: 
                 154796 
               
               
                 Refseq: 
                 NM_133265 | NM_001113490 
               
            
           
           
               
            
               
                 Protein sequence isoform 2 (SEQ ID NO (106)): 
               
            
           
           
               
               
            
               
                 1 
                 mpraqpssas yqpvpadpfa ivsraqqmve ilsdenrnlr qelegcyekv arlqkvetei 
               
               
                 61 
                 qrvseayenl vkssskreal ekamrnkleg eirrmhdfnr dlrerletan kqlaekeyeg 
               
               
                 121 
                 sedtrktisq lfaknkesqr ekekleaela tarstnedqr rhieirdqal snaqakvvkl 
               
               
                 181 
                 eeelkkkqvy vdkvekmqqa lvqlqaacek reqlehrlrt rlereleslr iqqrqgncqp 
               
               
                 241 
                 tnvseynaaa lmellrekee rilaleadmt kweqkyleen vmrhfaldaa atvaaqrdtt 
               
               
                 301 
                 vishspntsy dtaleariqk eeeeilmank rcldmegrik tlhaqiiekd amikvlqqrs 
               
               
                 361 
                 rkepskteql scmrpakslm sisnagsgll shsstltgsp imeekrddks wkgslgillg 
               
               
                 421 
                 gdyraeyvps tpspvppstp llsahsktgs rdcstqterg tesnktaava pisvpapvaa 
               
               
                 481 
                 aataaaitat aatitttmva aapvavaaaa apaaaaapsp ataaataaav spaaagqipa 
               
               
                 541 
                 aasvasaaav apsaaaaaav qvapaapapv papalvpvpa paaaqasapa qtqaptsapa 
               
               
                 601 
                 vaptpaptpt pavaqaevpa spatgpgphr lsipsltcnp dktdgpvfhs ntlerktpiq 
               
               
                 661 
                 ilgqepdaem veyli 
               
               
                   
               
            
           
           
               
            
               
                 Protein sequence isoform 1 (SEQ ID NO (107)): 
               
            
           
           
               
               
            
               
                 1 
                 mrnseeqpsg gttvlqrllq eqlrygnpse nrsllaihqq atgngppfps gsgnpgpqsd 
               
               
                 61 
                 vlspqdhhqq lvahaarqep qgqeiqsenl imekqlsprm qnneelptye eakvqsqyfr 
               
               
                 121 
                 gqqhasvgaa fyvtgvtnqk mrtegrpsvq rlnpgkmhqd eglrdlkqgh vrslserlmq 
               
               
                 181 
                 mslatsgvka hppvtsapls ppqpndlykn ptsssefyka qgplpnqhsl kgmehrgppp 
               
               
                 241 
                 eypfkgmppq svvckpqepg hfysehrlnq pgrtegqlmr yqhppeygaa rpaqdislpl 
               
               
                 301 
                 sarnsqphsp tssltsggsl pllqsppstr lsparhplvp nqgdhsahlp rpqqhflpnq 
               
               
                 361 
                 ahqgdhyrls qpglsqqqqq qqqqhhhhhh hqqqqqqqpq qqpgeaysam praqpssasy 
               
               
                 421 
                 qpvpadpfai vsraqqmvei lsdenrnlrq elegcyekva rlqkveteiq rvseayenlv 
               
               
                 481 
                 kssskreale kamrnklege irrmhdfnrd lrerletank qlaekeyegs edtrktisql 
               
               
                 541 
                 faknkesqre kekleaelat arstnedqrr hieirdqals naqakvvkle eelkkkqvyv 
               
               
                 601 
                 dkvekmqqal vqlqaacekr eqlehrlrtr lereleslri qqrqgncqpt nvseynaaal 
               
               
                 661 
                 mellrekeer ilaleadmtk weqkyleenv mrhfaldaaa tvaaqrdttv ishspntsyd 
               
               
                 721 
                 taleariqke eeeilmankr cldmegrikt lhaqiiekda mikvlqqrsr kepskteqls 
               
               
                 781 
                 cmrpakslms isnagsglls hsstltgspi meekrddksw kgslgillgg dyraeyvpst 
               
               
                 841 
                 pspvppstpl lsahsktgsr dcstqtergt esnktaavap isvpapvaaa ataaaitata 
               
               
                 901 
                 atitttmvaa apvavaaaaa paaaaapspa taaataaavs paaagqipaa asvasaaava 
               
               
                 961 
                 psaaaaaavq vapaapapvp apalvpvpap aaaqasapaq tqaptsapav aptpaptptp 
               
               
                 1021 
                 avaqaevpas patgpgphrl sipsltcnpd ktdgpvfhsn tlerktpiqi lgqepdaemv 
               
               
                 1081 
                 eyli 
               
               
                   
               
               
                 Gene ID: 
                 Z7 
               
               
                 Gene symbol: 
                 ENPEP 
               
               
                 Gene description: 
                 glutamyl aminopeptidase (aminopeptidase A) 
               
               
                 Unigene: 
                 Hs.435765 
               
               
                 Genbank: 
                 L12468 
               
               
                 Entrez Gene: 
                 2028 
               
               
                 Refseq: 
                 NM_001977 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (108)): 
               
            
           
           
               
               
            
               
                 1 
                 mnfaeregsk ryciqtkhva ilcavvvgvg livglavglt rscdssgdgg pgtapapshl 
               
               
                 61 
                 psstaspsgp paqdqdicpa sedesgqwkn frlpdfvnpv hydlhvkpll eedtytgtvs 
               
               
                 121 
                 isinlsaptr ylwlhlretr itrlpelkrp sgdqvqvrrc feykkqeyvv veaeeeltps 
               
               
                 181 
                 sgdglylltm efagwlngsl vgfyrttyte ngqvksivat dheptdarks fpcfdepnkk 
               
               
                 241 
                 atytisithp keygalsnmp vakeesvddk wtrttfeksv pmstylvcfa vhqfdsvkri 
               
               
                 301 
                 snsgkpltiy vqpeqkhtae yaanitksvf dyfeeyfamn yslpkldkia ipdfgtgame 
               
               
                 361 
                 nwglityret nllydpkesa ssnqqrvatv vahelvhqwf gnivtmdwwe dlwlnegfas 
               
               
                 421 
                 ffeflgvnha etdwqmrdqm lledvlpvqe ddslmsshpi ivtvttpdei tsvfdgisys 
               
               
                 481 
                 kgssilrmle dwikpenfqk gcqmylekyq fknaktsdfw aaleeasrlp vkevmdtwtr 
               
               
                 541 
                 qmgypvlnvn gvknitqkrf lldpranpsq ppsdlgytwn ipvkwtedni tssvlfnrse 
               
               
                 601 
                 kegitlnssn psgnaflkin pdhigfyrvn yevatwdsia talslnhkif ssadraslid 
               
               
                 661 
                 dafalaraql ldykvalnlt kylkreenfl pwqrvisavt yiismfeddk elypmieeyf 
               
               
                 721 
                 qgqvkpiads lgwndagdhv tkllrssvlg fackmgdrea lnnasslfeq wlngtvslpv 
               
               
                 781 
                 nlrllvyryg mqnsgneisw nytleqyqkt slaqekekll yglasvknvt llsryldllk 
               
               
                 841 
                 dtnliktqdv ftviryisyn sygknmawnw iqlnwdylvn rytlnnrnlg rivtiaepfn 
               
               
                 901 
                 telqlwqmes ffakypqaga gekpreqvle tvknniewlk qhrntirewf fnllesg 
               
               
                   
               
               
                 Gene ID: 
                 Z8 
               
               
                 Gene symbol: 
                 THY1 
               
               
                 Gene description: 
                 Thy-1 cell surface antigen 
               
               
                 Unigene: 
                 Hs.644697 
               
               
                 Genbank: 
                 AP003396 
               
               
                 Entrez Gene: 
                 7070 
               
               
                 Refseq: 
                 NM_006288 
               
            
           
           
               
            
               
                 Protein sequence (SEQ ID NO (109)): 
               
            
           
           
               
               
            
               
                 1 
                 mnlaisiall ltvlqvsrgq kvtsltaclv dqslrldcrh entssspiqy efsltretkk 
               
               
                 61 
                 hvlfgtvgvp ehtyrsrtnf tskynmkvly lsaftskdeg tytcalhhsg hsppissqnv 
               
               
                 121 
                 tvlrdklvkc egisllaqnt swllllllsl sllqatdfms l