Patent Publication Number: US-2021161766-A1

Title: Pharmaceutical management system

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This is a continuation application of International Patent Application No.PCT/JP2019/023421 filed Jun. 13, 2019, which claims the benefit of priority to Japanese Patent Application No.2018-151306 filed Aug. 10, 2018, the entire contents of each of which the entire contents of each of which are incorporated herein by reference. 
    
    
     BACKGROUND 
     Technical Field 
     The present disclosure relates to a pharmaceutical management system. 
     Description of the Related Art 
     For example, pharmaceutical refrigerators to store pharmaceuticals in an environment at a predetermined refrigeration temperature is known (for example, see Japanese Patent Application Publication No.2000-105149). 
     In a medical institution, a pharmaceutical of a pharmaceutical manufacturer delivered from a pharmaceutical wholesaler is stored in a pharmaceutical refrigerator and kept in an environment at a predetermined refrigeration temperature optimal for the pharmaceutical. However, in actual, the pharmaceutical manufacturer and the pharmaceutical wholesaler cannot sufficiently grasp information on the medical institution side such as how the pharmaceutical is managed in terms of temperature and when the pharmaceutical is consumed by being prescribed. Thus, there is a possibility that the pharmaceutical cannot be smoothly distributed among the medical institution, the pharmaceutical wholesaler, and the pharmaceutical manufacturer. 
     Accordingly, the present disclosure is directed to provision of a pharmaceutical management system capable of smoothly distributing a pharmaceutical among a medical institution, a pharmaceutical wholesaler, and a pharmaceutical manufacturer. 
     SUMMARY 
     A primary aspect of the present disclosure is a pharmaceutical management system comprising: an IC tag attached to a pharmaceutical; a pharmaceutical storage box to store the pharmaceutical and read information of the IC tag; a controller to acquire the information of the IC tag from the pharmaceutical storage box and manage the pharmaceutical; and a pharmaceutical refrigerator to store the pharmaceutical storage box to refrigerate the pharmaceutical. 
     Other features of the present disclosure will become apparent from the following description and the drawings. 
     According to the present disclosure, it is possible to smoothly distribute a pharmaceutical among a medical institution, a pharmaceutical wholesaler, and a pharmaceutical manufacturer. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a block diagram illustrating an example of a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 2  is a perspective view illustrating an example of a pharmaceutical refrigerator to be used in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 3  is a perspective view illustrating how a pharmaceutical storage box is taken in and out of a pharmaceutical refrigerator of  FIG. 2 . 
         FIG. 4  is a perspective view illustrating an example of a pharmaceutical storage box to be used in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 5  is a perspective view illustrating another example of a pharmaceutical storage box to be used in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 6  is a plan view illustrating an example of a coupling device for leading out a coupling line of an antenna to the outside in a pharmaceutical storage box of  FIG. 5   
         FIG. 7  is a block diagram specifically illustrating a pharmaceutical management system illustrated in  FIG. 1 . 
         FIG. 8  is a view illustrating an example of a table stored in a storage device to be used in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 9  is a view illustrating another example of a table stored in a storage device to be used in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 10  is a view illustrating another example of a table stored in a storage device to be used in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 11  is a plan view for explaining an example in which a pharmaceutical storage box actually storing a pharmaceutical is to be determined when the same ID information is acquired simultaneously from multiple pharmaceutical storage boxes in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 12  is a flowchart for explaining an example of a determination operation of a controller in  FIG. 11 . 
         FIG. 13  is a plan view for explaining another example in which a pharmaceutical storage box actually storing a pharmaceutical is to be determined when the same ID information is acquired simultaneously from multiple pharmaceutical storage boxes in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 14  is a flowchart for explaining an example of a determination operation of a controller in  FIG. 13 . 
         FIG. 15  is a flowchart for explaining an example of an operation of determining whether a pharmaceutical has been taken out of a pharmaceutical storage box or not in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 16  is a flowchart for explaining another example of an operation of determining whether a pharmaceutical has been taken out of a pharmaceutical storage box or not in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 17  is a view illustrating an example of a management status of pharmaceuticals that is displayed on a display unit in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 18A  is a view illustrating an example of a screen displayed on a display unit as a procedure for confirming putting-in of pharmaceuticals in one process in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 18B  is a view illustrating an example of a screen displayed on a display unit as a procedure for confirming putting-in of pharmaceuticals in one process in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 18C  is a view illustrating an example of a screen displayed on a display unit as a procedure for confirming putting-in of pharmaceuticals in one process in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 19A  is a view illustrating an example of a screen displayed on a display unit as a procedure for confirming taking-out of pharmaceuticals in one process in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 19B  is a view illustrating an example of a screen displayed on a display unit as a procedure for confirming taking-out of pharmaceuticals in one process in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 19C  is a view illustrating an example of a screen displayed on a display unit as a procedure for confirming taking-out of pharmaceuticals in one process in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 20A  is a view illustrating an example of a screen displayed on a display unit as a procedure for confirming taking-out for return of pharmaceuticals in one process in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 20B  is a view illustrating an example of a screen displayed on a display unit as a procedure for confirming taking-out for return of pharmaceuticals in one process in a pharmaceutical management system according to an embodiment of the present disclosure. 
         FIG. 20C  is a view illustrating an example of a screen displayed on a display unit as a procedure for confirming taking-out for return of pharmaceuticals in one process in a pharmaceutical management system according to an embodiment of the present disclosure. 
     
    
    
     DETAILED DESCRIPTION 
     At least the following matters will be apparent from illustration in the description and the attached drawings. 
     Pharmaceutical Management System 
     A medical institution sometimes handles a pharmaceutical that is high cost and needs strict distribution management (for example, an antineoplastic agent, a therapeutic agent for hemophilia, a plasma preparation, an albumin preparation, a therapeutic agent for autoimmune, a vaccine, a therapeutic agent for a rare disease, or the like. Hereinafter, also referred to as “specialty pharmaceutical” for convenience of explanation) as a pharmaceutical of a pharmaceutical manufacturer delivered from a pharmaceutical wholesaler. In this case, the medical institution needs to strictly manage temperature such that the specialty pharmaceutical stored in a pharmaceutical refrigerator is kept at a temperature optimal for the specialty pharmaceutical. However, in actual, the pharmaceutical manufacturer and the pharmaceutical wholesaler cannot sufficiently grasp information on the medical institution side, such as how the specialty pharmaceutical is managed in terms of temperature. Accordingly, the medical institution cannot return the specialty pharmaceutical to the pharmaceutical manufacturer or the pharmaceutical wholesaler, which may hinder the distribution of all pharmaceuticals including the specialty pharmaceutical among the medical institution, the pharmaceutical wholesaler, and the pharmaceutical manufacturer. Thus, a pharmaceutical management system according to an embodiment of the present disclosure is proposed so that pharmaceuticals are smoothly distributed among the medical institution, the pharmaceutical wholesaler, and the pharmaceutical manufacturer. 
       FIG. 1  is a block diagram illustrating an example of the pharmaceutical management system according to an embodiment of the present disclosure. 
     The pharmaceutical management system  1  includes a pharmaceutical refrigerator  100 , a pharmaceutical storage box  200 , an IC tag  300 , a controller  400 , and storage devices  500 ,  600 ,  700 . 
     The pharmaceutical refrigerator  100  is an apparatus that keeps a pharmaceutical  310  in an environment at an optimal refrigeration temperature. The pharmaceutical storage box  200  is a device to store the pharmaceutical  310  with the IC tag  300  attached thereto, the pharmaceutical storage box  200  having a function of receiving ID information indicating the pharmaceutical  310  stored in the IC tag  300 . The pharmaceutical storage box  200  is to be stored in the pharmaceutical refrigerator  100 . The controller  400  is a device to acquire the ID information stored in the IC tag  300  from the pharmaceutical storage box  200  and manage the ID information in association with, for example, information on refrigeration temperature and putting-in and taking-out of the pharmaceutical  310 . The storage devices  500 ,  600 ,  700  are devices that are accessibly coupled to the controller  400  and into and from which the controller  400  appropriately stores and reads information needed for management of the pharmaceutical  310 . The storage devices  500 ,  600 ,  700  may be configured with hard disks included in a personal computers or configured with data servers to be accessed via a network. The pharmaceutical refrigerator  100 , the pharmaceutical storage box  200 , the IC tag  300 , the controller  400 , and the storage devices  500 ,  600 ,  700  will be described later in detail. 
     &lt;&lt;Pharmaceutical Refrigerator&gt;&gt; 
       FIG. 2  is a perspective view illustrating an example of the pharmaceutical refrigerator to be used for the pharmaceutical management system according to an embodiment of the present disclosure is to be stored.  FIG. 3  is a perspective view illustrating how the pharmaceutical storage box is taken in and out of the pharmaceutical refrigerator of  FIG. 2 . 
     The pharmaceutical refrigerator  100  is an apparatus that is installed, for example, in a medical institution, and that stores pharmaceuticals (pharmaceutical products) of a pharmaceutical manufacturer delivered via a pharmaceutical wholesaler, and refrigerates them at an optimal temperature. 
     The pharmaceutical refrigerator  100  includes an outer case  110 , an inner case  120 , a machine room  130 , a door  140 , a temperature sensor  150 , and a door sensor  160 . 
     The outer case  110  has a rectangular cuboid shape and has an opening  111  on a front surface thereof for loading and unloading pharmaceuticals. The inner case  120  has a rectangular cuboid shape, has an opening  121  on a front surface thereof to communicate with the opening  111 , and is provided in the outer case  110  with a heat insulating material provided between the inner case  120  and the outer case  110 . Multiple shelves  122  are provided in the inner case  120  to store the pharmaceuticals. The shelves  122  have, for example, a mesh shape to allow air to pass therethrough. The machine room  130  is formed below the inner case  120  in the outer case  110  and a cooling device (not illustrated) that refrigerates the inside of the inner case  120  is provided. The cooling device circulates coolant by using, for example, a compressor, a condenser, an evaporator, and the like, and is coupled to the inner case  120  such that air at a predetermined refrigeration temperature circulates in the inner case  120 . The door  140  has a glass window  141  (front glass) for checking the inside of the inner case  120 , and is slidably attached to the opening  111  of the outer case  110 . Closing the door  140  causes the inside of the inner case  120  to be a closed space and enables refrigeration of the pharmaceuticals. 
     In an embodiment of the present disclosure, it is assumed that the pharmaceutical storage box  200  for storing the pharmaceutical  310  to be managed is placed on one of the shelves  122  in the inner case  120  of the pharmaceutical refrigerator  100  so as to be insertably removable from the pharmaceutical refrigerator through the openings  111 ,  121 . 
     The temperature sensor  150  is a sensor with a glycol bottle that can detect the temperature of the pharmaceutical in the inner box  120  without being affected by a temperature change caused by opening and closing of the door  140  of the pharmaceutical refrigerator  100  and circulation of air in the pharmaceutical refrigerator  100 , for example, and is attached to a predetermined position (for example, an inner surface) in the inner box  120  to enable accurate detection of the temperature of the pharmaceutical  310  in the pharmaceutical storage box  200  placed on one of the shelves  122 . Note that, when multiple pharmaceutical storage boxes  200  are to be stored in the pharmaceutical refrigerator  100 , multiple temperature sensors  150  may be attached to predetermined positions corresponding to the multiple pharmaceutical storage boxes  200  (for example, positions on surfaces of the shelves  122  where the pharmaceutical storage boxes  200  are to be placed) in the inner box  120  to enable respective accurate detections of the temperatures of the pharmaceuticals  310  in the multiple pharmaceutical storage boxes  200 . 
     The door sensor  160  is a sensor to detect opening and closing of the door  140  and is attached to an inner surface of the opening  111 . The door sensor  160  is configured using, for example, a microswitch. 
     &lt;&lt;Pharmaceutical Storage Box&gt;&gt; 
     A pharmaceutical storage box  200 A (first example) and a pharmaceutical storage box  200 B (second example) will be described below as the pharmaceutical storage box  200 . Note that one or both of the pharmaceutical storage boxes  200 A,  200 B may be selectively stored in the pharmaceutical refrigerator  100 . 
     &lt;First Example&gt; 
       FIG. 4  is a perspective view illustrating an example of the pharmaceutical storage box to be used for the pharmaceutical management system according to an embodiment of the present disclosure. In  FIG. 3 , an X-axis is an axis extending in a width direction of the pharmaceutical storage box, a Y-axis is an axis extending in a front-back direction of the pharmaceutical storage box, and a Z-axis is an axis extending in a height direction of the pharmaceutical storage box. 
     The pharmaceutical storage box  200 A is a box for storing pharmaceuticals  310  to be managed. 
     The pharmaceutical storage box  200 A includes a storage portion  210  and an antenna  220 . 
     The storage portion  210  is defined by a total of four flat plates of a bottom plate  211 , side plates  212 ,  213 , and a back plate  214 . The storage portion  210  may be formed, for example, such that the bottom plate  211 , the side plates  212 ,  213 , and the back plate  214  are integrally formed by die molding using a resin material. Alternatively, the storage portion  210  may be formed, for example, such that the bottom plate  211 , the side plates  212 ,  213 , and the back plate  214  are separately formed by die molding using a resin material, and then the bottom plate  211 , the side plates  212 ,  213 , and the back plate  214  are bonded to one another with adhesive and/or the like. The storage portion  210  has multiple air passage holes  215  in each of the bottom plate  211 , the side plates  212 ,  213 , and the back plate  214  such that the pharmaceuticals  310  stored in the storage portion  210  are effectively refrigerated by the air circulating in the inner case  120 . 
     The IC tag  300  for identifying the pharmaceutical  310  is attached to each pharmaceutical  310 . In an embodiment of the present disclosure, it is assumed that the IC tag  300  is a passive RFID tag including a loop coil and an IC chip, for example. The ID information indicating the pharmaceutical  310  is stored in the IC chip in advance. The IC chip stores in advance the ID information, such as a “product code” assigned to the pharmaceutical  310  itself, a “pharmaceutical name”, a “manufacturer code” indicating the pharmaceutical manufacturer, a “reception date” of the pharmaceutical  310 , an “expiration date” of the pharmaceutical  310 , a “lot number” of the pharmaceutical  310 , “image data” of the pharmaceutical  310 , and the like. 
     The antenna  220  is a device configured to transmit a radio wave in the storage portion  210  to activate the IC chip in the IC tag  300  attached to each pharmaceutical  310 , and receive the ID information indicating the pharmaceutical  310 . The ID information received by the antenna  220  is stored, by a controller described later, in the storage device  500  as information for managing the pharmaceutical  310 . The antenna  220  has a flat plate shape and is attached to, for example, a surface of the side plate  212  facing the side plate  213 . 
     Storing the pharmaceuticals  310  in the pharmaceutical storage box  200 A and storing the pharmaceutical storage box  200 A in the pharmaceutical refrigerator  100  enables management of the pharmaceuticals  310  and the pharmaceutical storage box  200 A storing the pharmaceuticals  310 . In addition, the pharmaceutical storage box  200 A is associated with the antenna  220 , which enables identification of the pharmaceutical storage box  200 A. Thus, it is also possible to manage the pharmaceuticals  310  and the pharmaceutical storage boxes  200 A storing the pharmaceuticals  310  such that the pharmaceuticals  310  are sorted according to their types, pharmaceutical wholesalers, pharmaceutical manufacturers, and/or the like, and separately stored in multiple pharmaceutical storage boxes  200 A, and then the multiple pharmaceutical storage boxes  200 A are stored in the pharmaceutical refrigerator  100 . In addition, a pharmaceutical refrigerator  100  already installed in a medical institution or the like can also be used to store the pharmaceutical storage boxes  200 A. 
     &lt;Second Example&gt; 
       FIG. 5  is a perspective view illustrating another example of the pharmaceutical storage box to be used for the pharmaceutical management system according to an embodiment of the present disclosure. In  FIG. 5 , an X-axis is an axis extending in a width direction of the pharmaceutical storage box, a Y-axis is an axis extending in a front-back direction of the pharmaceutical storage box, and a Z-axis is an axis extending in a height direction of the pharmaceutical storage box.  FIG. 6  is a plan view illustrating an example of a coupling portion for leading out a coupling line of an antenna in the pharmaceutical storage box of  FIG. 5 . Note that, in the second example, the same components as those in the first example are denoted by the same reference numerals and description thereof is omitted. 
     A pharmaceutical storage box  200 B is a box for storing the pharmaceuticals  310  to be managed. 
     The pharmaceutical storage box  200 B includes the storage portion  210  and antennas  220 ,  230 . 
     The antennas  220 ,  230  are devices configured to transmit radio waves in the storage portion  210  to activate the IC chip in the IC tag  300  attached to each pharmaceutical  310 , and receive the ID information indicating the pharmaceutical  310 . The ID information received by the antennas  220 ,  230  is stored, by the controller described later, in the storage device  500  as the information for managing the pharmaceutical  310 . 
     In the first example, when the pharmaceutical  310  is stored in the pharmaceutical storage box  200 B such that the surface of the IC tag  300  is positioned perpendicular to the surface of the antenna  220  facing the side plate  213 , the radio wave transmitted from the antenna  220  and the loop coil in the IC tag  300  may not be interlinked, and thus the antenna  220  may not correctly receive the ID information indicating the pharmaceutical  310  from the IC chip in the IC tag  300  thereof. Specifically, when the pharmaceutical  310  is stored in the pharmaceutical storage box  200  such that the surface of the IC tag  300  is along a plane formed by the X-axis and the Z-axis, the surface (surface extending along the plane formed by the X-axis and the Z-axis) of the IC tag  300  is positioned perpendicular to the surface (surface extending along a plane formed by the Y-axis and the Z-axis) of the antenna  220  facing the side surface  213 , and thus the antenna  220  may not correctly receive the ID information indicating the pharmaceutical  310  from the IC chip in the IC tag  300  thereof. For example, when the pharmaceutical  310  is enclosed in a vial and the IC tag  300  is attached to a side surface of the vial, the aforementioned issue may arise. 
     Thus, the antenna  230  having a flat plate shape is attached to a surface of the back plate  214  between the side plates  212  and  213 . This establishes a positional relationship that the surface (surface extending along the plane formed by the Y-axis and the Z-axis) of the antenna  220  is perpendicular to the surface (surface extending along the plane formed by the X-axis and the Z-axis) of the antenna  230 . Accordingly, the antennas  220 ,  230  can correctly receive the ID information indicating each pharmaceutical  310  from the IC chip in the IC tag  300  thereof, regardless of the direction in which the pharmaceutical  310  is stored about the Z-axis. 
     A coupling line (communication line)  221  of the antenna  220  and a coupling line (communication line)  231  of the antenna  230  are, for example, coupled to an external controller via a connector  170  provided at a corner on the rear side of the pharmaceutical refrigerator  100  so as not to hinder putting-in and taking-out of the pharmaceutical storage box  200 B. The pharmaceutical storage box  200 B can be easily taken in and out by plugging and unplugging the connector  170 . 
     &lt;&lt;Controller&gt;&gt; 
       FIG. 7  is a block diagram specifically illustrating the pharmaceutical management system illustrated in  FIG. 1 . 
     The controller  400  is a device to associate and manage the information on the refrigeration temperature and the putting-in and taking-out of the pharmaceutical  310  based on the ID information of the IC tag  300  that is received by the antenna  220  ( 230 ), temperature information of the pharmaceutical  310  in the pharmaceutical storage box  200  placed on the shelf  122  in the inner box  120  that is detected by the temperature sensor  150 , and open-close information of the door  140  that is detected by the door sensor  160 . 
     The controller  400  includes a transmission-reception device  410 , an input unit  420 , a clock unit  430 , a control unit  440 , a storage unit  450 , and a display unit  460 . 
     The transmission-reception device  410  is an interface for acquiring, at regular time intervals, the ID information of the IC tag  300  that is received by the antenna  220  ( 230 ), the temperature information of the pharmaceutical  310  in the pharmaceutical storage box  200  placed on the shelf  122  in the inner box  120  that is detected by the temperature sensor  150 , and the open-close information of the door  140  that is detected by the door sensor  160 . In addition, the transmission-reception device  410  is also an interface to be used to access the storage devices  500 ,  600 ,  700 . 
     The input unit  420  receives various commands. 
     The clock unit  430  keeps track of the current time and measures a predetermined time period with respect to the current time as a reference. 
     The control unit  440  performs control for associating and managing the information on the refrigeration temperature and the putting-in and taking-out of the pharmaceutical  310 . The control unit  440  is implemented by using, for example, a microcomputer. 
     The storage unit  450  stores in advance a program for associating and managing the information on the refrigeration temperature and the putting-in and taking-out of the pharmaceutical  310 . The control unit  440  is operated by executing the program read from the storage unit  450 . 
     The display unit  460  is a display that displays visual information where the information on the refrigeration temperature and the putting-in and taking-out of the pharmaceutical  310  are associated. 
     Although the input unit  420  and the display unit  460  are described as separate ones in this description, the input unit  420  and the display unit  460  may be an integral touch panel display. 
     &lt;&lt;Storage Device&gt;&gt; 
       FIG. 8  is a view illustrating an example of a table stored in the storage device to be used in the pharmaceutical management system according to an embodiment of the present disclosure. 
     The storage device  500  is a database for storing pieces of ID information (product codes, pharmaceutical names, manufacturer codes, reception dates, expiration dates, lot numbers, image data) indicating the pharmaceuticals  310  and are stored in advance in the IC tags  300 , while regarding one pharmaceutical storage box  200  as a unit. For example, assume a case where two pharmaceutical storage boxes  200  are stored in the pharmaceutical refrigerator  100 , two pharmaceuticals  310  are stored in one pharmaceutical storage box  200 , and three pharmaceuticals  310  are stored in the other pharmaceutical storage box  200 . In this case, the storage device  500  stores two pieces of ID information in a storage region allocated for the one pharmaceutical storage box  200  and stores three pieces of ID information in a storage region allocated for the other pharmaceutical storage box  200 . 
     The controller  400  accesses the antennas  220  ( 230 ) in all the pharmaceutical storage boxes  200  stored in the pharmaceutical refrigerator  100  via the transmission-reception device  410  at regular time intervals, by causing the control unit  440  to operate according to the program read by the control unit  440  from the storage unit  450 . When the pieces of ID information stored in the IC chips in the IC tags  300  are received by the antennas  220  ( 230 ), the pieces of ID information are stored as a table via the transmission-reception device  410  in storage regions for the respective pharmaceutical storage boxes  200  set in the storage device  500 . Note that, with respect to ID information that is not stored in the storage regions, the storage device  500  newly stores it in the corresponding storage region(s), and with respect to ID information that is already stored in the storage region(s), the storage device  500  overwrites and stores it in the corresponding storage region(s). 
       FIG. 9  is a view illustrating another example of the table stored in the storage device to be used in the pharmaceutical management system according to an embodiment of the present disclosure. 
     The storage device  600  is a database for storing the temperature information detected by the temperature sensor  150  while regarding one pharmaceutical storage box  200  as a unit. For example, assume a case where two pharmaceutical storage boxes  200  are stored in the pharmaceutical refrigerator  100  and two temperature sensors  150  are attached corresponding to the two pharmaceutical storage boxes  200 , respectively. In this case, the storage device  600  stores temperature information detected by one temperature sensor  150  attached corresponding to one pharmaceutical storage box  200  and temperature information detected by the other temperature sensor  150  attached corresponding to the other pharmaceutical storage box  200 , in storage regions, respectively. 
     The controller  400  accesses the temperature sensors  150  via the transmission-reception device  410  at regular time intervals, by causing the control unit  440  to operate according to the program read by the control unit  440  from the storage unit  450 . The pieces of temperature information acquired by the temperature sensors  150  are stored, via the transmission-reception device  410 , as tables in the storage regions for the pharmaceutical storage boxes  200  set in the storage device  600 , respectively. Note that the storage device  600  may overwrite and store the pieces of temperature information acquired by the temperature sensors  150 , or may accumulate and store the pieces of temperature information acquired by the temperature sensors  150  such that changes in temperature inside the pharmaceutical storage boxes  200  over time are understandable. 
       FIG. 10  is a view illustrating another example of the table stored in the storage device to be used in the pharmaceutical management system according to an embodiment of the present disclosure. 
     The storage device  700  is a database in which, when the controller  400  determines that the pharmaceutical  310  has been put into or taken out of the pharmaceutical refrigerator  100 , the product code of the pharmaceutical  310  is associated with information indicating put-in check time and take-out check time of the pharmaceutical  310 , an antenna code assigned to the antenna  220  ( 230 ), and a reception signal strength of a signal received by the antenna  220  ( 230 ) from the IC tag  300  attached to the pharmaceutical  310  and storing these pieces of information while regarding one pharmaceutical storage box  200  as a unit. Note that, in an embodiment of the present disclosure, it is assumed that, when the controller  400  acquires the ID information from the antenna  220  ( 230 ) via the transmission-reception device  410 , the information indicating the antenna code and the reception signal strength is attached to the ID information. For example, assume a case where two pharmaceutical storage boxes  200  are stored in the pharmaceutical refrigerator  100 , two pharmaceuticals  310  are stored in one pharmaceutical storage box  200 , and three pharmaceutical  310  are stored in the other pharmaceutical storage box  200 . In this case, the storage device  700  stores the information indicating the product codes, the put-in check times, the take-out check times, the antenna codes, and the reception signal strengths relating to the two pharmaceuticals  310  in a storage region allocated for the one pharmaceutical storage box  200 , and stores the information indicating the product codes, the put-in check times, the take-out check times, the antenna codes, and the reception signal strengths relating to the three pharmaceuticals  310  in a storage region allocated for the other pharmaceutical storage box  200 . 
     The controller  400  accesses the antennas  220  ( 230 ) in all the pharmaceutical storage boxes  200  stored in the pharmaceutical refrigerator  100  via the transmission-reception device  410  at regular time intervals, by causing the control unit  440  to operate according to the program read by the control unit  440  from the storage unit  450 . When any of the pieces of ID information acquired from the antennas  220  ( 230 ) is ID information not stored in the storage device  500 , the controller  400  determines that the pharmaceutical  310  has been put in. Then, the controller  400  associates the current time obtained by the clock unit  430  as the put-in check time with the antenna code and the reception signal strength, and stores the put-in check time in the storage region allocated for the pharmaceutical storage box  200  corresponding to the antenna code. In contrast, when the antenna  220  ( 230 ) no longer detects the piece of ID information of the pharmaceutical  310  that has been put-in, the controller  400  determines that the pharmaceutical  310  has been taken out. The controller  400  associates the current time obtained by the clock unit  430  as the take-out check time with the antenna code and the reception signal strength, and stores the take-out check time in the storage region allocated for the pharmaceutical storage box  200  corresponding to the antenna code. 
     &lt;&lt;Determination on Putting-in of Pharmaceutical&gt;&gt; 
     First Example 
       FIG. 11  is a plan view for explaining an example in which a pharmaceutical storage box actually storing a pharmaceutical is to be determined when the same ID information is acquired simultaneously from multiple pharmaceutical storage boxes in the pharmaceutical management system according to an embodiment of the present disclosure. For the convenience of explanation, it is assumed that, for example, three pharmaceutical storage boxes  200 A are placed adjacent to one another in the width direction (direction extending along the X-axis) on one shelf  122 . Specifically, in two pharmaceutical storage boxes  200 A adjacent to each other, the side plate  212  of one pharmaceutical storage box  200 A and the side plate  213  of the other pharmaceutical storage box  200 A face each other. In addition, it is assumed that the pharmaceutical  310  is stored only in the pharmaceutical storage box  200 A on the right side (−X side) of the drawing. 
       FIG. 12  is a flowchart for explaining an example of a determination operation of the controller in  FIG. 11 . The determination operation of the controller is implemented by causing the control unit  440  to operate according to the program read from the storage unit  450 . 
     A radio wave emitted from each antenna  220  has such a directivity that the radio wave mainly travels in a direction of a broken line arrow (−X direction) from the side plate  212  toward the side plate  213  in the pharmaceutical storage box  200 A. Accordingly, at the same time when the antenna  220  of the pharmaceutical storage box  200 A on the right side of the drawing receives the ID information from the IC tag  300  attached to the pharmaceutical  310 , the antennas  220  of the pharmaceutical storage boxes  200 A on the left side and at the center of the drawing may erroneously receive the ID information from the same IC tag  300  although no pharmaceuticals  310  are stored in the pharmaceutical storage boxes  200 A on the left side and at the center of the drawing. In other words, the storage device  700  may erroneously store the same information as the information on the pharmaceutical  310  stored in the pharmaceutical storage box  200 A on the right side of the drawing, into respective storage regions for the pharmaceutical storage boxes  200 A on the left side and at the center of the drawing. Thus, when the storage device  700  erroneously stores the same information as the information on the pharmaceutical  310  stored in the pharmaceutical storage box  200 A on the right side of the drawing into the respective storage regions for the pharmaceutical storage boxes  200 A on the left side and at the center of the drawing, this information needs to be deleted. 
     First, the controller  400  accesses the storage device  700  to refer to the respective storage regions for the three pharmaceutical storage boxes  200 A and determines whether the same information on the pharmaceutical  310  is stored or not, in other words, determines whether information of the same product code and the same put-in check time is stored or not (step S 101 ). 
     For example, when information of the same product code and the same put-in check time is stored in the respective storage regions for the three pharmaceutical storage boxes  200 A (step S 101 : YES), the controller  400  determines that the pharmaceutical  310  is stored in the pharmaceutical storage box  200 A on the right side of the drawing that is located most downstream in the direction in which the radio waves are emitted from the antennas  220 , based on the directivity of the radio waves emitted from the antennas  220  (step S 102 ). Note that, when information of the same product code and the same put-in check time is not stored in the respective storage regions for the three pharmaceutical storage boxes  200 A (step S 101 : NO), the controller  400  executes the determination operation of the step S 101  again. 
     Next, the controller  400  deletes the information that is stored in the respective storage regions for the pharmaceutical storage boxes  200 A on the left side and at the center of the drawing and that is the same as the information on the pharmaceutical  310  stored in the pharmaceutical storage box  200 A on the right side of the drawing, according to the determination result of the step S 102  (step S 103 ). 
     This enables correct management of the put-in information of the pharmaceutical  310 . 
     SECOND EXAMPLE 
       FIG. 13  is a plan view for explaining another example in which a pharmaceutical storage box actually storing a pharmaceutical is to be determined when the same ID information is acquired simultaneously from multiple pharmaceutical storage boxes in the pharmaceutical management system according to an embodiment of the present disclosure. For the convenience of explanation, it is assumed that, for example, three pharmaceutical storage boxes  200 B are placed adjacent to one another in the width direction (direction extending along the X-axis) on one shelf  122 . Specifically, in two pharmaceutical storage boxes  200 B adjacent to each other, the side plate  212  of one pharmaceutical storage box  200 B and the side plate  213  of the other pharmaceutical storage box  200 B face each other. In addition, it is assumed that the pharmaceutical  310  is stored only in the pharmaceutical storage box  200 B on the right side (−X side) of the drawing. 
       FIG. 14  is a flowchart for explaining an example of a determination operation of the controller in  FIG. 13 . The determination operation of the controller is implemented by causing the control unit  440  to operate according to the program read from the storage unit  450 . 
     A radio wave emitted from each antenna  220  has such a directivity that the radio wave mainly travels in a direction of a broken line arrow (−X direction) from the side plate  212  toward the side plate  213  in the pharmaceutical storage box  200 B. Accordingly, at the same time when the antenna  220  of the pharmaceutical storage box  200 B on the right side of the drawing receives the ID information from the IC tag  300  attached to the pharmaceutical  310 , the antennas  220  of the pharmaceutical storage boxes  200 B on the left side and at the center of the drawing may erroneously receive the ID information from the same IC tag  300  although no pharmaceutical  310  is stored in the pharmaceutical storage boxes  200 B on the left side or at the center of the drawing. In other words, the storage device  700  may erroneously store the same information as the information on the pharmaceutical  310  stored in the pharmaceutical storage box  200 B on the right side of the drawing, into respective storage regions for the pharmaceutical storage boxes  200 B on the left side and at the center of the drawing. Thus, when the storage device  700  erroneously stores the same information as the information on the pharmaceutical  310  stored in the pharmaceutical storage box  200 B on the right side of the drawing into the respective storage regions for the pharmaceutical storage boxes  200 B on the left side and at the center of the drawing, this information needs to be deleted. 
     Each pharmaceutical storage box  200 B has the antenna  230  in addition to the antenna  220 . A radio wave emitted from the antenna  230  has such a directivity that the radio wave travels mainly in a direction of a dashed-dotted line arrow (−Y direction) away from the back plate  214  in the pharmaceutical storage box  200 B. In other words, there is a low possibility that the antennas  230  of the pharmaceutical storage box  200 B on the left side and at the center of the drawing erroneously receive the ID information from the IC tag  300  of the pharmaceutical  310  stored in the pharmaceutical storage box  200 B on the right side of the drawings. Accordingly, determination of the pharmaceutical storage box  200 B storing the pharmaceutical  310  may be performed based on information indicating the reception signal strengths of the antennas  220 ,  230 . 
     First, the controller  400  accesses the storage device  700  to refer to the respective storage regions for the three pharmaceutical storage boxes  200 B, and determines whether the same information on the pharmaceutical  310  is stored or not, in other words, determines whether information of the same product code and the same put-in check time is stored or not (step S 201 ). 
     For example, when information of the same product code and the same put-in check time is stored in the respective storage regions for the three pharmaceutical storage boxes  200 B (step S 201 : YES), the controller  400  compares the reception signal strengths of the antennas  220 ,  230  among the three pharmaceutical storage boxes  200 B, and determines that the pharmaceutical  310  is stored in the pharmaceutical storage box  200 B on the right side of the drawing to which the antennas  220 ,  230  having the greatest reception signal strengths are attached (step S 202 ). Note that, when information of the same product code and the same put-in check time is not stored in the respective storage regions for the three pharmaceutical storage boxes  200 B (step S 201 : NO), the controller  400  executes the determination operation of the step S 201  again. 
     Next, the controller  400  deletes the information that is stored in the respective storage regions for the pharmaceutical storage boxes  200 B on the left side and at the center of the drawing and that is the same as the information on the pharmaceutical  310  stored in the pharmaceutical storage box  200 B on the right side of the drawing, according to the determination result of the step S 202  (step S 203 ). 
     This enables correct management of the put-in information of the pharmaceutical  310 . 
     &lt;&lt;Determination on Taking-out of Pharmaceutical&gt;&gt; 
     For example, assume a case where the pharmaceutical  310  to be taken out is taken out among multiple pharmaceuticals  310  stored in the pharmaceutical storage box  200 . In this case, when a hand of a worker which is a dielectric is inserted between the antenna  220  ( 230 ) and the IC tag  300  of the pharmaceutical  310  that is not to be taken out, the radio wave emitted from the antenna  220  ( 230 ) does not sufficiently reach the IC tag  300  of the pharmaceutical  310  that is not to be taken out. As a result, the pharmaceutical  310  that is not to be taken out may be erroneously determined as the pharmaceutical  310  having been taken out although the pharmaceutical  310  is present in the pharmaceutical storage box  200 . In addition, for example, when some of multiple pharmaceuticals  310  stored in the pharmaceutical storage box  200  are temporarily taken out of the pharmaceutical storage box  200  in order to change the arrangement of the multiple pharmaceuticals  310 , the radio wave emitted from the antenna  220  ( 230 ) does not reach the IC tags  300  of the temporarily-taken-out pharmaceuticals  310 . As a result, the temporarily-taken-out pharmaceuticals  310  may be erroneously determined as the pharmaceuticals  310  having been taken out although the pharmaceuticals  310  will be returned to the pharmaceutical storage box  200 . Thus, it is needed to correctly determine a state in which the pharmaceutical  310  has been taken out. 
     FIRST EXAMPLE 
       FIG. 15  is a flowchart for explaining an example of an operation of determining whether the pharmaceutical has been taken out of the pharmaceutical storage box or not in the pharmaceutical management system according to an embodiment of the present disclosure. The determination operation of the controller  400  is implemented by causing the control unit  440  to operate according to the program read from the storage unit  450 . In addition, for the convenience of explanation, it is assumed that the controller  400  starts the determination operation with an initial state in which the door  140  of the pharmaceutical refrigerator  100  is closed. 
     First, the controller  400  acquires the open-close information of the door  140  from the door sensor  160  at regular time intervals. Specifically, the controller  400  acquires a close signal indicating that the door  140  is closed or an open signal indicating that the door  140  is open from the door sensor  160  at regular time intervals (for example, at intervals of five seconds). For example, assume a case where the door sensor  160  is configured using a microswitch. In this case, when the door  140  is closed, the microswitch is on, to thereby cause the door sensor  160  to output the close signal. When the door  140  is open, the microswitch is off, to thereby cause the door sensor  160  to output the open signal. Then, the controller  400  determines whether the open signal is acquired from the door sensor  160  or not (step S 301 ). 
     When the controller  400  acquires no open signal from the door sensor  160  (step S 301 : NO), the controller  400  executes the determination operation of step S 301  again. Meanwhile, when the controller  400  acquires the open signal from the door sensor  160  (step S 301 : YES), the controller  400  invalidates the information acquired from the antenna  220  ( 230 ), since there is a high possibility that whether the pharmaceutical  310  has been put in or taken out is uncertain in association with the door  140  being open. Specifically, the controller  400  invalidates the information of the antenna  220  ( 230 ) during a time period during which the door  140  is open, regardless of whether the controller  400  acquires new ID information from the antenna  220  ( 230 ) or no longer acquires the existing (already-acquired) ID information from the antenna  220  ( 230 ) (step S 302 ). 
     Next, the controller  400  determines whether the close signal is acquired from the door sensor  160  or not (step S 303 ). When the controller  400  acquires no close signal from the door sensor  160  (step S 303 : NO), the controller  400  executes the operation of step S 302  and the determination operation of step S 303  again. Meanwhile, when the controller  400  acquires the close signal from the door sensor  160  (step S 303 : YES), the controller  400  starts measuring time with respect to the current time as a reference using the clock unit  430  such that a time period elapsed from the closing of the door  140  can be grasped (step S 304 ). 
     Next, the controller  400  determines whether a time period measured by the clock unit  430  reaches a certain time period (for example, five minutes) or not (step S 305 ). 
     When the clock unit  430  has not measured the certain time period yet (step S 305 : NO), the controller  400  determines whether the open signal is acquired or not from the door sensor  160  while the clock unit  430  is measuring the certain time (step S 306 ). When no open signal is acquired from the door sensor  160  (step S 306 : NO), the controller  400  executes the determination operation of step S 305  again. Meanwhile, when the open signal is acquired from the door sensor  160  (step S 306 : YES), the controller  400  stops the operation of measuring time of the clock unit  430  and resets a measured time (step S 307 ), and then executes step S 302  again. 
     Meanwhile, when the clock unit  430  has measured the certain time period (step S 305 : YES), there is a high possibility that whether the pharmaceutical  310  has been put in or taken out is determined. Thus, the controller  400  validates the information acquired from the antenna  220  ( 230 ). Specifically, when the controller  400  acquires new ID information from the antenna  220  ( 230 ), the controller  400  determines that the corresponding pharmaceutical  310  has been put in. When the controller  400  no longer acquires existing ID information from the antenna  220  ( 230 ), the controller  400  determines that the corresponding pharmaceutical  310  has been taken out (step S 308 ). The controller  400  then executes step S 301  again. 
     This enables correct management of the put-in information and the take-out information of the pharmaceutical  310 . 
     In addition, assume a case where the pharmaceutical storage box  200 B ( FIG. 5 ) is stored in the pharmaceutical refrigerator  100 . In this case, the radio wave emitted from the antenna  230  attached to the back plate  214  has such a directivity that the radio wave travels mainly toward the glass window  141 . Accordingly, when the pharmaceutical  310  is removed out of the pharmaceutical storage box  200 B, to be taken out, and then is temporarily placed outside the pharmaceutical refrigerator  100  across the glass window  141 , the antenna  230  may receive the ID information from the IC tag  300  attached to this pharmaceutical  310  and it may be erroneously determined that the pharmaceutical  310  has not been taken out. Accordingly, it is assumed that a sheet  142  that shields radio waves is attached to the glass window  141 . 
     SECOND EXAMPLE 
       FIG. 16  is a flowchart for explaining another example of the operation of determining whether the pharmaceutical has been taken out of the pharmaceutical storage box or not in the pharmaceutical management system according to an embodiment of the present disclosure. The determination operation of the controller  400  is implemented by causing the control unit  440  to operate according to the program read from the storage unit  450 . 
     First, the controller  400  determines whether the existing (already-acquired) ID information is no longer acquired from the antenna  220  ( 230 ) or not (step S 401 ). When the controller  400  is continuously acquiring the existing ID information from the antenna  220  ( 230 ) (step S 401 : YES), the controller  400  executes the determination operation of step S 401  again. Meanwhile, when the controller  400  no longer acquires the existing ID information from the antenna  220  ( 230 ) (step S 401 : NO), the controller  400  starts measuring time with respect to the current time as a reference using the clock unit  430  such that a time period elapsed from non-acquisition of the existing ID information can be grasped (S 402 ). 
     Next, the controller  400  determines whether a time period measured by the clock unit  430  reaches a certain time period (for example, five minutes) or not (step S 403 ). 
     When the clock unit  430  has not measured the certain time period yet (step S 403 : NO), the controller  400  determines whether the existing ID information is acquired or not while the clock unit  430  is measuring the certain time (step S 404 ). When the controller  400  does not acquire the existing ID information (step S 404 : NO), the controller  400  executes the determination operation of step S 403  again. Meanwhile, when the controller  400  acquires the existing ID information (step S 404 : YES), the controller  400  stops the operation of measuring time of the clock unit  430  to reset a measured time (step S 405 ) and then executes the determination operation of step S 401  again. 
     Meanwhile, when the clock unit  430  has measured the certain time period (step S 403 : YES), the controller  400  determines that the corresponding pharmaceutical  310  has been taken out (step S 406 ) and then executes the determination operation of step S 401  again. 
     This enables correct management of the take-out information of the pharmaceutical  310 . 
     In the case where the pharmaceutical storage box  200 B ( FIG. 5 ) is stored in the pharmaceutical refrigerator  100 , it is assumed that the sheet  142  that shields radio waves is attached to the glass window  141  as in the first example. 
     &lt;&lt;Display Example of Management Status of Pharmaceutical&gt;&gt; 
       FIG. 17  is a view illustrating an example of a management status of pharmaceuticals that is displayed on the display unit in the pharmaceutical management system according to an embodiment of the present disclosure. A display operation of the controller  400  is implemented by causing the control unit  440  to operate according the program read from the storage unit  450 . 
     When the input unit  420  receives a display command for displaying the management status of pharmaceuticals  310  on the display unit  460 , the controller  400  refers to the tables in the storage devices  500 ,  600 ,  700  as appropriate and displays visual information indicating a “put-in list”, “pharmaceutical information”, and a “put-in history” on the display unit  460 . 
     The put-in list is visual information indicating the management statuses of all the pharmaceuticals  310  stored in the pharmaceutical refrigerator  100 , and pieces of information indicating the product code, the pharmaceutical name, the expiration date, and the temperature, for example, are associated with one another for each of the pharmaceuticals  310 . In the put-in list, it is possible to display the pharmaceuticals  310  such that they are sorted according to any one of the product code, the pharmaceutical name, and the expiration date, or they are grouped based on the pharmaceutical storage boxes  200 . In addition, it is possible to display the put-in list while updating it at regular time intervals (for example, five seconds). Furthermore, it is possible to display fields of expired pharmaceuticals  310  so as to be distinguishable (for example, high-lighted, blinking, and/or the like) from pharmaceuticals  310  that are not expired in the put-in list. 
     The pharmaceutical information is visual information indicating various pieces of information on the pharmaceutical  310  selected from the multiple pharmaceuticals  310  displayed in the put-in list, where, for example, the pharmaceutical name, the manufacturer code, the reception date, the expiration date, the lot number, and the image are associated with one another. 
     The put-in history is visual information indicating the put-in status of the pharmaceutical  310  selected from the multiple pharmaceuticals  310  displayed in the put-in list, where, for example, pieces of information indicating the put-in check time, the antenna code, the reception signal strength, and the temperature are associated with one another. 
     As such, pieces of information on the refrigeration temperature and the putting-in and taking-out of each pharmaceutical  310  are associated with one another and displayed on the display unit  460  as a list, which enables correct recognition of the management status of the pharmaceutical  310 . 
     In addition, assume a case where the pharmaceutical management system  1  according to an embodiment of the present disclosure is constructed among the medical institution, the pharmaceutical wholesaler, and the pharmaceutical manufacturer. In this case, since the pieces of information on the refrigeration temperature and the putting-in and taking-out of each pharmaceutical  310  are managed while being associated with one another, a specialty pharmaceutical can be returned from the medical institution to the pharmaceutical wholesaler and the pharmaceutical manufacturer. This enables smooth distribution of pharmaceuticals including the specialty pharmaceutical. 
     &lt;&lt;Procedures of Putting-in and Taking-out of Pharmaceuticals&gt;&gt; 
       FIGS. 18A to 18C  are views illustrating examples of screens displayed on the display unit as a procedure for confirming putting-in of the pharmaceuticals in one process.  FIGS. 19A to 19C  are views illustrating examples of screens displayed on the display unit as a procedure for confirming taking-out of the pharmaceuticals in one process.  FIGS. 20A to 20C  are views illustrating examples of screens displayed on the display unit as a procedure for confirming taking-out for return of the pharmaceuticals in one process. A display process of the display unit  460  is executed by causing the control unit  440  to operate according to the program read from the storage unit  450 . In addition, it is assumed that the close signal of the door sensor  160  triggers determination of putting-in and taking-out of the pharmaceuticals  310  as illustrated in  FIG. 16 , for example. 
     &lt;Put-in Process&gt; 
     First, when a command for managing putting-in and taking-out of the pharmaceuticals  310  is input to the input unit  420 , the controller  400  causes the display unit  460  to display a screen ( FIG. 18A ) for selecting one of “put-in”, “take-out”, and “take-out for return” of the pharmaceuticals  310 . 
     Next, in response to a worker clicking a button of “put-in”, the controller  400  causes the display unit  460  to display a put-in operation screen ( FIG. 18B ). In response to an instruction on the put-in operation screen, the worker opens the door  140  of the pharmaceutical refrigerator  100  to store all the pharmaceuticals  310  to be put into the pharmaceutical storage box  200  and then closes the door  140  of the pharmaceutical refrigerator  100 . 
     Next, in response to acquisition of the close signal from the door sensor  160 , the controller  400  acquires the ID information of the pharmaceuticals  310  from the antenna  220  ( 230 ). When the controller  400  acquires ID information of new pharmaceuticals  310  from the antenna  220  ( 230 ), the controller  400  causes a put-in operation screen ( FIG. 18C ) displaying pieces of information on the new pharmaceuticals  310  (items such as pharmaceutical name, manufacturing number, duration of use, and EPC code) in a list to be displayed. The worker checks that all the pharmaceuticals  310  to be put in are displayed in the list and clicks a button of “put-in confirmation”. The controller  400  thereby stores, into the storage device  700 , the information on all the pharmaceuticals  310  to be put in in one process. Accordingly, usability relating to confirmation process of the pharmaceuticals  310  to be put in is improved. 
     &lt;Take-out Process&gt; 
     First, when a command for managing putting-in and taking-out of the pharmaceuticals  310  is input to the input unit  420 , the controller  400  causes the display unit  460  to display a screen ( FIG. 19A ) for selecting one of “put-in”, “take-out”, and “take-out for return” of the pharmaceuticals  310 . 
     Next, in response to the worker clicking a button of “take-out”, the controller  400  causes the display unit  460  to display a take-out operation screen ( FIG. 19B ). In response to an instruction on the take-out operation screen, the worker opens the door  140  of the pharmaceutical refrigerator  100  to take all the pharmaceuticals  310  to be taken out, out of the pharmaceutical storage box  200 , and then closes the door  140  of the pharmaceutical refrigerator  100 . 
     Next, in response to acquisition of the close signal from the door sensor  160 , the controller  400  acquires the ID information of the pharmaceuticals  310  from the antenna  220  ( 230 ). When the controller  400  no longer acquires the ID information of the existing pharmaceuticals  310  from the antenna  220  ( 230 ), the controller  400  causes a take-out operation screen ( FIG. 19C ) displaying pieces of information on the existing pharmaceuticals  310  (items such as pharmaceutical name, manufacturing number, duration of use, and EPC code) in a list to be displayed. The worker checks that all the pharmaceuticals  310  to be taken out are displayed in the list, and clicks a button of “take-out confirmation”. The controller  400  thereby stores, into the storage device  700 , the information on all the pharmaceuticals  310  to be taken out in one process. Accordingly, usability relating to confirmation process of the pharmaceuticals  310  to be taken out is improved. 
     &lt;Take-out-for-Return Process&gt; 
     A take-out-for-return process is a process performed on the pharmaceuticals  310  to be returned among the aforementioned take-out processes, and a procedure for the take-out-for-return process is substantially the same as the aforementioned procedure for the take-out process. 
     First, when a command for managing putting-in and taking-out of the pharmaceuticals  310  is input to the input unit  420 , the controller  400  causes the display unit  460  to display a screen ( FIG. 20A ) for selecting one of “put-in”, “take-out”, and “take-out for return” of the pharmaceuticals  310 . 
     Next, in response to the worker clicking a button of “take-out for return”, the controller  400  causes the display unit  460  to display a take-out-for-return operation screen ( FIG. 20B ). In response to an instruction on the take-out-for-return operation screen, the worker opens the door  140  of the pharmaceutical refrigerator  100  to take all the pharmaceuticals  310  to be taken out for return out of the pharmaceutical storage box  200 , and then closes the door  140  of the pharmaceutical refrigerator  100 . 
     Next, in response to acquisition of the close signal from the door sensor  160 , the controller  400  acquires the ID information of the pharmaceuticals  310  from the antenna  220  ( 230 ). When the controller  400  no longer acquires the ID information of the existing pharmaceuticals  310  from the antenna  220  ( 230 ), the controller  400  causes a take-out-for-return operation screen ( FIG. 20C ) displaying pieces of information on the existing pharmaceuticals  310  (items such as pharmaceutical name, manufacturing number, duration of use, and EPC code) in a list to be displayed. The worker checks that all the pharmaceuticals  310  to be taken out for return are displayed in the list, and clicks a button of “take-out-for-return confirmation”. The controller  400  thereby stores, into the storage device  700 , the information on all the pharmaceuticals  310  to be taken out for return in one process. Accordingly, usability relating to confirmation process of the pharmaceuticals  310  to be taken out for return is improved. 
     Embodiments of the present disclosure described above are simply to facilitate understanding of the present disclosure and are not in any way to be construed as limiting the present disclosure. The present disclosure may variously be changed or altered without departing from its essential features and encompass equivalents thereof. For example, the IC tag  300  may be a tag into and from which data can be written and read so as to enable correction and update of information on the pharmaceutical  310  in response to an instruction from the controller  400 .