Title: Recommendations

Context:
An age of 30 years was chosen based on how age was categorized in the six studies that showed an inverse  relationship between age and OUD or overdose. One of those six studies found that patients with OUD  were younger than patients without OUD, but did not find a statistically significant relationship.[87] Two of  those six studies examined age as a continuous predictor, and neither reported a specific age where the  risk of OUD or overdose changed markedly.[62,92] One study examined age as a dichotomous (<65 and  ≥65) predictor.[88] In the two remaining studies, the highest risk included ages ranging from 18 to 30  years.[59,86] As such, the Work Group chose 30 years of age as a clinically reasonable threshold.

Question: How was an age of 30 years chosen as a clinically reasonable threshold?

Answer: An age of 30 years was chosen based on how age was categorized in the six studies that showed an inverse  relationship between age and OUD or overdose.