Title: Recommendations

Context:
Harms may outweigh benefits for the concurrent use of benzodiazepines and LOT. There is moderate quality evidence that concurrent use of benzodiazepines with prescription opioids increases the risk of  overdose and overdose death.[66] In a retrospective cohort study, the adjusted odds ratio (AOR) for drug  overdose was highest for individuals on LOT for chronic pain (without anxiety or PTSD) who also received  concurrent long-term benzodiazepine therapy.[66] In another retrospective study that involved over  200,000 participants (not included in the evidence review), Veterans receiving both opioids and  benzodiazepines were at an increased risk of death from drug overdose.[90] Furthermore, there is a lack of  evidence in favor of long-term therapy with benzodiazepines and opioids for chronic pain.[91]

Question: Who were at an increased risk of death from drug overdose?

Answer: Veterans receiving both opioids and  benzodiazepines