Title: Recommendations

Context:
There is concern for additional overdose risk associated with long-acting versus short-acting opioids. A  study (not included in the evidence review due to its design) suggests increased risk for non-fatal overdose  in VA patients with initiation of a long-acting opioid compared with immediate-release opioids.[137] Also,  recent research demonstrates that patients with CNCP on long-acting OT have a significantly increased risk  of all-cause mortality compared to patients with CNCP who are taking an analgesic anticonvulsants or a  low-dose antidepressant.[10]

Question: Who has a significantly increased risk  of all-cause mortality compared to patients with CNCP who are taking an analgesic anticonvulsants or a  low-dose antidepressant?

Answer: patients with CNCP on long-acting OT