Title: Recommendations

Context:
Abuse Deterrent Formulations of Opioids: The aim of most abuse deterrent formulations is to present a physical barrier to prevent chewing,  crushing, cutting, grating, or grinding of the dosage form, or present a chemical barrier, such as a gelling  agent, that will resist extraction of the opioid with use of a common solvent. Alternatively, an opioid  antagonist (naloxone or naltrexone) can be added to interfere with, reduce, or defeat the euphoria  associated with abuse of an agent intended for oral use when taken nasally or parenterally.[142] While  these properties deter abuse they do not fully prevent abuse; no opioid formulation prevents consumption  of a large number of intact capsules or tablets which continues to be the most common method of abuse.

Question: What can be added to interfere with, reduce, or defeat the euphoria  associated with abuse of an agent intended for oral use when taken nasally or parenterally?

Answer: an opioid  antagonist (naloxone or naltrexone)