Title: Recommendations

Context:
Future Research: Future research is needed to better determine the impact of systematic reductions in MEDD in terms of  pain relief, specific pain and medical conditions, overdose morbidity and mortality as well as potential  adverse outcomes (e.g., the incidence of associated OUD, infectious diseases related to intravenous drug  use disorder, and drug-related crime and diversion) and to determine whether/which conditions may be  appropriately treated with LOT. Research is also needed to determine how frequency of monitoring should be impacted by dose.

Question: What needs to be better determined by researchers?

Answer: the impact of systematic reductions in MEDD in terms of  pain relief, specific pain and medical conditions, overdose morbidity and mortality as well as potential  adverse outcomes (e.g., the incidence of associated OUD, infectious diseases related to intravenous drug  use disorder, and drug-related crime and diversion) and to determine whether/which conditions may be  appropriately treated with LOT