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recently, it has been accepted that [TOPICWISE] therapy may be beneficial for rheumatoid arthritis (ra).

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this finding suggests a potential novel strategy for therapeutic interventions of this disease.

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the reverse transcription‑quantitative polymerase chain reaction and western blot analysis were used to measure the expression levels of biological pathway‑associated proteins caspase‑3, caspase‑7, tumor necrosis factor receptor superfamily member [TOPICWISE] ([TOPICWISE]), growth regulated α protein ([TOPICWISE]), c‑x‑c motif chemokine 2 ([TOPICWISE]), c‑x‑c chemokine receptor type 2 ([TOPICWISE]), vascular endothelial growth factor (vegf)a, [TOPICWISE] and vegf.

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[TOPICWISE] analysis revealed targeting onto 3'-utr of [TOPICWISE] by [TOPICWISE].

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a new study of peptide vaccines in advanced renal cell carcinoma patients provides important insights into these central issues.

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[TOPICWISE] (1.

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various mechanisms deregulate integrin signaling in cancer, empowering tumor cells with the ability to proliferate without restraint, to invade through tissue boundaries, and to survive in foreign microenvironments.

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on the other hand, the most abundant secondary metabolite in the sponge [TOPICWISE] sp., [TOPICWISE], shows effective cytotoxic activity against different types of cancer cells.

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to characterize the landscape of pharmacogenomic interactions in liver cancers, we developed a protocol to establish human liver cancer cell models at a success rate of around 50% and generated the liver cancer model repository ([TOPICWISE]) with 81 cell models.

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furthermore, downregulation of [TOPICWISE] notably induced [TOPICWISE] and inhibited tumor growth in a mouse xenograft model of glioma.

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bioinformatics indicated that [TOPICWISE] factor (hif)-1α was a putative target gene of [TOPICWISE], and this was confirmed by a luciferase reporter assay, which demonstrated that [TOPICWISE] was able to directly bind to the 3' untranslated region of [TOPICWISE] mrna.

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volumes of vestibular [TOPICWISE] were estimated by cuboidal, ellipsoidal, and spherical formulas based on a [TOPICWISE] model, and cuboidal, ellipsoidal, [TOPICWISE]'s, and ice cream cone formulas based on a [TOPICWISE] model.

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besides, we observed that [TOPICWISE] evoked pi3k/akt/mtor activation through elevation of [TOPICWISE] in [TOPICWISE] [TOPICWISE] cells.

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from the above study, it was suggested that fortified bread reduces the glycaemic index and is best suited for diabetic people and diet watchers.

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it was discover that, [TOPICWISE]-mediated [TOPICWISE] overexpression inhibited cancer cell [TOPICWISE] in vitro and in vivo, invasion and cisplatin chemoresistance.

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rna [TOPICWISE] and rip assays identified the binding of [TOPICWISE] and [TOPICWISE] to [TOPICWISE] ([TOPICWISE]).

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[TOPICWISE].456, p = 0.007) and [TOPICWISE] (high vs. medium tbs: hr = 2.542, 95% ci = 1.

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in vitro assays revealed that [TOPICWISE] igg upregulated [TOPICWISE] macrophage markers [TOPICWISE] and [TOPICWISE] in human [TOPICWISE] cells and peripheral macrophages.

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a total of 48 [TOPICWISE] in 21/26 (81%) patients with a mean size of 20 ± 10 mm were detected by histopathology (9/48, 19%) or imaging [TOPICWISE] (39/48, 81%).

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loss of the gastrointestinal transcription factor [TOPICWISE] leads to [TOPICWISE] of the embryonal [TOPICWISE] [TOPICWISE] in [TOPICWISE]-negative tumors.

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in contrast, [TOPICWISE], a less curable disease subtype, contains an intact blood brain barrier, rendering this tumor impermeable and resistant to chemotherapy.

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to investigate the clinical benefit of routine esophageal screening in newly diagnosed head and neck squamous cell carcinoma ([TOPICWISE]) patients.

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the [TOPICWISE] of [TOPICWISE] can inhibit the proliferation, invasion and metastasis of [TOPICWISE] cells.

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downregulation of [TOPICWISE] may induce apoptosis and inhibit autophagy in crc cells by regulation of [TOPICWISE]/[TOPICWISE] axis and pi3k/akt/mtor pathway.

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however, whether [TOPICWISE]‑[TOPICWISE]‑5p is involved in the regulation of melanoma remains unclear.

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in addition, the wnt/[TOPICWISE] signaling pathway was repressed via knockdown of [TOPICWISE] in [TOPICWISE], while the wnt/[TOPICWISE] signaling pathway was promoted via overexpression of [TOPICWISE] in [TOPICWISE].

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dysregulation of certain lncrnas is known to be linked to the tumorigenesis of nsclc.

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targeting tissue stiffness improves the outcome of [TOPICWISE] therapy and prolongs patient survival.

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moreover, we explored the regulatory mechanism of [TOPICWISE] and found that [TOPICWISE] directly bound [TOPICWISE] 132 ([TOPICWISE]) in nsclc cells.

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however, notwithstanding the limitations of [TOPICWISE] studies, the subgroup of prostate cancer patients receiving external beam radiation therapy ([TOPICWISE]) showed an increased risk of rectal cancer.

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in addition, [TOPICWISE] knockdown significantly reduced the viability and proliferation of [TOPICWISE] and [TOPICWISE] cells.

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additionally, in vivo tumor xenografts in nude mice showed that ectopic overexpression of [TOPICWISE] inhibited the tumor growth of bc cells.

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collectively, we uncover the function of [TOPICWISE] and provide an attractive therapy for tah.

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there was strained activation of wnt/[TOPICWISE] pathway via declining [TOPICWISE].

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the most frequent authors on [TOPICWISE] literature were identified using the same search strategy as in a systematic review and invited to participate in a [TOPICWISE] delphi survey.

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laryngeal squamous cell carcinoma ([TOPICWISE]) is rare in the young.

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25(oh)d deficiency (<50 nmol/l) was associated with higher [TOPICWISE] mortality (hr 1.87, 95% ci 1.

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[TOPICWISE] human melanoma xenografts growing in dorsal window chambers were used as tumor model.

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dnp induced the change in abundance of mitochondrial proteins, mediated the status of oxidative stress and the imbalance of redox state, increased cytoskeletal protein, cathepsin, anterior [TOPICWISE], and [TOPICWISE] expression.

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to identify msi target genes, we developed a statistical model for the somatic background [TOPICWISE] mutation rate of microsatellites to assess mutation significance.

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mice vaccinated with [TOPICWISE]-sr and the [TOPICWISE]-encoding plasmid ([TOPICWISE]) drastically reduced the frequencies of [TOPICWISE]-specific ctls and were unable to suppress lung melanoma metastasis in vivo, as compared with mice vaccinated only with [TOPICWISE].

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we show strong [TOPICWISE] concordance and identify features of drug response.

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[TOPICWISE] specifically inhibited [TOPICWISE] expression.

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here, we show that [TOPICWISE] and [TOPICWISE] mutations are mutually exclusive and experimentally synthetic lethal.

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additionally, [TOPICWISE] mimics is a potential therapeutic agent for the treatment of mm.

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[TOPICWISE] and chip assay were utilized to assess the role of h1.

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the heterogeneity of brain cancers, as most solid tumors, complicates diagnosis and treatment.

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[TOPICWISE], pten, and phosphorylated akt ([TOPICWISE]) protein expressions were tested by western blot.

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the contemporary [TOPICWISE] os rate was 65.2% in taiwan.

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mounting evidence has indicated that targeting fak, either alone or in combination with other agents, may represent a promising therapeutic strategy for various cancers.

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in dtc+ patients, the distribution of tumor k(trans) and kep were significantly (p < 0.01) more shifted towards lower values than in dtc- patients.

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however, univariate and multivariate cox analyses showed no statistically significant association between the expression of the investigated biomarkers and overall survival or relapse.

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clinical oncology is advancing toward a more personalized treatment orientation, making the need to understand the biology of metastasis increasingly acute.

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in this study, we have shown that the s1p([TOPICWISE]) receptors are expressed in [TOPICWISE] and [TOPICWISE] human atc cell lines, both at mrna and protein level.

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these include formation and maintenance of specialized cell compartments in nerve axons, swift [TOPICWISE] of metabolites and restructuring of cell architecture in response to environmental cues in committed lymphocytes, and ensuring [TOPICWISE] [TOPICWISE] energy expenditure.

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these findings support an oncogene role of [TOPICWISE] in development of uveal melanoma.

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the expression and functions of [TOPICWISE]‑152 have previously been studied in several types of cancer.

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[TOPICWISE] polymerase chain reaction ([TOPICWISE]) and western blotting were performed to test [TOPICWISE], vegf and [TOPICWISE] mrna and protein expressions.

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objective response rate among patients with sclc was 36% (9/25), achieving the primary efficacy endpoint.

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patients with sci incurred a lower risk for prostate cancer compared with people without sci.

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flow cytometry and western blot tested cell apoptosis and the related protein levels in [TOPICWISE] cells after 45 mm glucose and 50 μm arb administration.

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furthermore, [TOPICWISE] isolated from de novo aml patients are uniquely reliant on amino acid metabolism for oxidative phosphorylation and survival.

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furthermore, [TOPICWISE]-[TOPICWISE]-5p was identified to specifically target [TOPICWISE].

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in conclusion the findings of the present study suggested that transfection with eukaryotic plasmid for the simultaneous expression of grim‑19 and [TOPICWISE] more effectively suppressed the growth of breast cancer in vitro and in vivo, and may therefore have therapeutic potential for the treatment of human breast cancer.

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[TOPICWISE] was upregulated and [TOPICWISE] was downregulated in ec tissues.

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locally advanced rectal cancers are currently treated with neoadjuvant concurrent chemoradiotherapy ([TOPICWISE]) followed by surgery, but risk stratification and final outcomes remain suboptimal.

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alterations in [TOPICWISE] interaction networks are at the core of malignant transformation but have yet to be translated into appropriate diagnostic tools.

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[TOPICWISE].546; p = 0.015), clinical t staging (hr, 2.240; 95% ci, 1.

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when the patent of innovator biopharmaceuticals expires, copies will be introduced.

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these findings indicated that [TOPICWISE] may act as a tumor suppressor in nsclc and may serve as a novel therapeutic agent for [TOPICWISE] therapy.

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moreover, wt1([TOPICWISE]) transduced cells expressed erythroid markers, including raised levels of [TOPICWISE], independently of addition of erythropoietin.

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here, we report an oncogenic role of [TOPICWISE] in promoting metastasis of [TOPICWISE].

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this may increase family members' sense of empowerment and coping, and positively influence how they experience the period both before and after the death of their loved ones.

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major complications occurred in 7.5% in the extended group, 19.4% in the [TOPICWISE] group, and 6.4% in the normal group; at one year, alive and living at home rates were 88.2%, 83.3%, and 97.8%, and overall [TOPICWISE] survival rates 75.6%, 62.4%, and 63.9% (p = 0.287), respectively.

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future strategies to decrease sunburn should target the practical, social, and psychological barriers associated with [TOPICWISE] of sun protection.

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polyethylene glycol (peg) is attached to many peptides, proteins, liposomes, and nanoparticles to reduce their immunogenicity and improve their pharmacokinetic and therapeutic properties.

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blood samples from [TOPICWISE] studies (study 1: 348 [TOPICWISE] and 39 normal controls and validation study 2: 411 [TOPICWISE] and 87 normal controls) were enrolled.

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accuracy was measured by calculating cohen's kappa coefficient (κ), which considers the possibility of agreement by chance.

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therefore, the aim of the present study was to determine the effects of targeting this molecule on ovarian carcinoma progression.

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[TOPICWISE] collaboration is challenging but the engagement of multiple stakeholders is a key step to reach common goals through research.

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the or for diabetes status was 1·81 (95% ci: 1·[TOPICWISE]·06) after adjustment for potential detection examinations.

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in this retrospective cohort, we examined the prognostic value of inos in um by performing immunohistochemistry on [TOPICWISE] sections of primary tumors (90 patients) and matched primary and metastatic hepatic tumors (19 patients) with complete histopathological and clinical data.

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the median [TOPICWISE] was 65.2 months (range 4.

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the high phosphorus, [TOPICWISE] and [TOPICWISE] nrf2 experimental groups all had increased nrf2, [TOPICWISE], [TOPICWISE], [TOPICWISE], and [TOPICWISE]/[TOPICWISE] expressions as well as high numbers of [TOPICWISE] compared with the normal control group.

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circ-[TOPICWISE] acts as a [TOPICWISE] sponge and positively regulated the target of [TOPICWISE], [TOPICWISE].

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intravitreal injection of [TOPICWISE] exerts a protective effect on macular edema secondary to diabetic retinopathy by affecting various cytokine concentrations, especially reducing aqueous vegf concentrations and interleukin 6 in patients with dme.

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in conclusion, [TOPICWISE] acts as an inhibitor of emt and metastasis of gc by targeting [TOPICWISE].

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the existence of multiple subsets of chronic lymphocytic leukemia expressing 'stereotyped' [TOPICWISE] receptors implies the involvement of antigen(s) in [TOPICWISE].

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since our study objective was earlier disease prediction than such, we propose further work should consider extending patient histories through e.g.

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[TOPICWISE] has been proposed for prostate cancer patients to provide an equivalent oncologic result to definitive treatment, with a reduced adverse effect profile, thus increasing the interest in [TOPICWISE] for the treatment of localized prostate cancer.

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knockdown of the five [TOPICWISE] target genes blocks senescence and apoptosis while it modestly delays proliferative arrest, thus partially recapitulating [TOPICWISE] function.

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we found that regulation and functions of [TOPICWISE] are different in malignant melanoma.

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in vitro, [TOPICWISE] inhibited the [TOPICWISE] uptake of rosuvastatin into [TOPICWISE]-overexpressing membrane vesicles with a [TOPICWISE] inhibitory concentration of 0.35 [TOPICWISE], whereas allopurinol showed no inhibition with concentrations up to 200 [TOPICWISE].

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[TOPICWISE] [TOPICWISE] and [TOPICWISE] [TOPICWISE] reduced degree of mitochondria swelling, and suppressed cardiomyocytes apoptosis in mice with sepsis.

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our findings indicated that [TOPICWISE] inhibits proliferation and promotes apoptosis in human eec cells by modulating the [TOPICWISE]/pten/akt/mtor signaling pathway, suggesting [TOPICWISE] could act a potential therapeutic agent in the eec treatment.

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this experimental design was based on [TOPICWISE] [TOPICWISE] to explore the pathogenesis of nsclc.

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gut microbiome was assessed using [TOPICWISE] rrna sequencing and shotgun [TOPICWISE] sequencing and correlated with objective response (complete or partial response), disease control (objective response or stable disease for ≥16 weeks), and overall survival.

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based on these results, we propose that [TOPICWISE] acid can be a prospective [TOPICWISE] therapeutic lead for the management of human gastric carcinoma.

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the aim of this study is to understand the [TOPICWISE] process regarding fertility choices among [TOPICWISE] women with cancer in taiwan.

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both from experimental and computational results, we observed that these compounds induced apoptosis by the same e6/[TOPICWISE] mechanism as aa, but at earlier time points, thus being far more effective than aa.

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