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lipopolysaccharide (lps)-induced murine [TOPICWISE] [TOPICWISE] cell model has been widely used for testing new osteoarthritis therapeutic targets.
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here, we report that kras [TOPICWISE] mutant cells treated with the covalent inhibitor [TOPICWISE] present [TOPICWISE]-modified peptides in [TOPICWISE] complexes.
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[TOPICWISE] inhibited the expression of [TOPICWISE] via targeting on 3'-utr of [TOPICWISE] gene.
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the [TOPICWISE] epigenetic silencing protein [TOPICWISE] is affected by [TOPICWISE] somatic mutations in b cell lymphomas.
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moreover, [TOPICWISE] negatively regulated [TOPICWISE] expression.
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our findings indicated that [TOPICWISE] could significantly augment the antiproliferative and [TOPICWISE] activities of sorafenib in vitro and in vivo.
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to shed light on this biological uncertainty, we investigated the spatial agreement between [TOPICWISE] maps produced by different rbe models, with emphasis on (smaller) substructures of the brainstem.
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the aim of the present study was to investigate to what extent tnm stage, treatment level, personality, choice of coping, mood and [TOPICWISE] quality of life ([TOPICWISE]) scores predicted distress as measured by general health questionnaire (ghq) in successfully treated head and neck squamous cell carcinoma ([TOPICWISE]) patients.
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however, the role and underlying mechanism of [TOPICWISE]-as2 in [TOPICWISE] cell lung cancer (nsclc) yet need to be unraveled.
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threatened fertility following cancer diagnosis in the reproductive age may severely impact emotional and psychosocial [TOPICWISE] in survivorship.
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the higher rate of distant recurrence (dr) and concomitant lr + dr in group 3 accounted for the survival difference.
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[TOPICWISE] reporter (dlr) genes were selected to analyze the target relationship of [TOPICWISE]-[TOPICWISE] to pten.
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thus, [TOPICWISE]-as1 enhances the aggressive phenotype of [TOPICWISE] cells in vitro and in vivo via the [TOPICWISE]-sp1 axis, which may represent a novel target for [TOPICWISE] therapy.
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its expression pattern and function in liver still needs further investigation.
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to investigate the effect of [TOPICWISE] [TOPICWISE] powder combined with photodynamic therapy (pdt) on the curative effect evaluation and prognosis of patients with rose acne.
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although they had similar concrete suggestions for improvements, system barriers and lack of time and focus on survivorship were seen to hamper implementation.
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recently, the role of long [TOPICWISE] rnas (lncrnas) in tumor progression has caught the attention of numerous researchers.
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[TOPICWISE].6, 0.
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the application of artificial intelligence in the field of education is becoming more and more extensive and [TOPICWISE].
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this article provides an overview of cervical cancer screening programmes in the nordic countries and whether the programmes adhere to international recommendations.
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the facts in the three groups of disease findings were compared.
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medical overuse is the leading cause of high expenditure among healthcare systems worldwide, with the degree varying from region to region.
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in a nude mouse xenograft model, [TOPICWISE] knockdown prominently slowed down tumor growth with reduced number of [TOPICWISE] positive cancer cells and elevated number of tunel positive cancer cells.
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a previous study showed decreased [TOPICWISE] ([TOPICWISE]) expression in hepatocellular carcinoma (hcc) patient's tumor tissues.
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preference for games and soap operas or films has a significant negative relationship with the mental health of college students, while the preference for science, education programs, and the preference to obtain current political news comments through official media have a positive impact on the psychological security of college students.
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our results suggested that lps induced the overexpression of [TOPICWISE] in [TOPICWISE], [TOPICWISE], [TOPICWISE], and [TOPICWISE]-7721 cells.
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with the global industrial integration, trade exchanges between countries are becoming more and more frequent and the competition for related international trade logistics is becoming more and more intense.
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to explore the clinical characteristics of metastatic colorectal cancer combined with gastrointestinal perforation and the prognostic value of circulating tumor dna ([TOPICWISE]).
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here we aim at explaining this variability using pre- and [TOPICWISE] inhibition transcriptional profiles in a panel of melanoma cell lines.
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functional analysis revealed that overexpression of [TOPICWISE]-5p significantly inhibited cell proliferation, migration, invasion in vitro, as well as suppressed tumor growth in vivo.
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the [TOPICWISE] expression increased the risk of recurrence with an odds ratio (or) of 2.50 (95% confidence interval [ci]; 1.
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rescue experiments indicated that [TOPICWISE] inhibition and [TOPICWISE] reintroduction reversed the effects of the [TOPICWISE] knockdown on gc cells.
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transfection of [TOPICWISE] inhibitor or psicor-[TOPICWISE] significantly elevated [TOPICWISE] expression and suppressed [TOPICWISE] expression, promoted cell apoptosis and inhibited proliferation.
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all 881 patients with [TOPICWISE] head and neck cancer treated with curative intent radiotherapy (rt) between 2005 and 2012 were retrospectively investigated.
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the findings imply that achieving parenthood, whether or not with biological children, is an area that needs to be addressed by health care services.
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the ses score (34.17 ± 9.81) in the observation group at 6 months after the operation was significantly higher than that before the operation (p < 0.05).
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these results demonstrate that [TOPICWISE] is a bona fide [TOPICWISE] gene whose loss contributes to [TOPICWISE] by blocking plasma cell differentiation.
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to report the outcomes of salvage [TOPICWISE] radical prostatectomy ([TOPICWISE]).
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j. cell.
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epithelial cell transforming sequence 2 ([TOPICWISE]) is frequently upregulated and acts as an oncogene in various human cancers.
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protein level was assessed with western blot assay and [TOPICWISE] immunosorbent assay (elisa).
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our study gives comprehensive insights into [TOPICWISE] biology.
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here, we conducted a [TOPICWISE] integrative analysis to investigate the functions of sc at different stages.
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after a period of at least three weeks, observers determined the skeletal age of all patients independently.
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to detect the methylation status of the cell fate determinant ([TOPICWISE]) gene in esophageal cancer tissues and to explore the predictive value of methylation of [TOPICWISE] on the sensitivity to radiotherapy for esophageal cancer.
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we also showed that [TOPICWISE] increased glucose transport in l6 skeletal muscle cells in vitro.
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report in nature that increasing glucose catabolism in brown adipose tissue by cold exposure lowers blood glucose and insulin tolerance.
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developing drugs against [TOPICWISE] has started a decade earlier than that on [TOPICWISE], and at present there are several molecules targeting [TOPICWISE] on the market.
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[TOPICWISE].7 years), while [TOPICWISE] overall survival was 81.3%.
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lncrnas [TOPICWISE] snps [TOPICWISE], [TOPICWISE], [TOPICWISE] and [TOPICWISE] were analyzed and their genotypic frequencies were examined by [TOPICWISE] polymerase chain reaction.
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circulating tumor dna is commonly detected though the presence of genetic alterations, but only a minor fraction of [TOPICWISE] [TOPICWISE] dna ([TOPICWISE]) fragments exhibit mutations.
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independent inhibition of [TOPICWISE] and overexpression of [TOPICWISE] expression levels significantly suppressed [TOPICWISE] cell proliferation, migration and invasion (p<0.01).
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[TOPICWISE] patients receiving [TOPICWISE] at turku university hospital (turku, finland) were enrolled in the study.
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overall survival (os) was estimated with [TOPICWISE], and differences were compared using cox regression, adjusted for baseline factors.
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oral cancer is a prevalent global issue, with oral squamous cell carcinoma constituting the majority of cases.
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restoration of [TOPICWISE] expression decreased breast cancer cell proliferation, migration and invasion in vitro and restricted tumor growth in vivo as well as increased cell apoptosis.
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there is a need for biomarkers that predict the tumor behavior in cc and allow stratification of patients that would benefit from adjuvant therapy.
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the mrna and protein expression of the jak2/stat3 signaling pathway and apoptosis related genes were determined through the use of [TOPICWISE] and western blot assay methods respectively.
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furthermore, we revealed that deficiency in [TOPICWISE], known regulator of alternative splicing, is associated with increased expression of a short [TOPICWISE] spliced isoform at the depend of the canonical long [TOPICWISE] isoform in rcc cells.
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in glioma, [TOPICWISE] mutations are associated with increased histone methylation and decreased [TOPICWISE] ([TOPICWISE]).
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we examined prostate cancer survival among aspirin and other nsaid users in the finnish prostate cancer screening trial.
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reverse transcription quantitative polymerase chain reaction ([TOPICWISE]) and western blot analysis were conducted to determine the expression of tlr4, cdk4, cyclin d1, livin, [TOPICWISE], [TOPICWISE], [TOPICWISE], and [TOPICWISE].
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therefore, exogenous [TOPICWISE] inhibits the proliferation, migration and invasion of human lung adenocarcinoma [TOPICWISE] cells as well as the chemotaxis of treg cells while promoting the apoptosis of [TOPICWISE] cells.
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[TOPICWISE] negatively targetted jak2.
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data regarding os and [TOPICWISE] treatment after [TOPICWISE] were collected.
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it helps to reshape the entire rural landscape, coordinate the growth of urban and rural areas, achieve the goal of a wealthy society in every way, boost demand, and support the holistic development of people.
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overall, our findings support the positive association between cord [TOPICWISE] concentration and the development of atherogenic lipid profile in newborns.
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furthermore, the egfr inhibitor [TOPICWISE] inhibited [TOPICWISE] [TOPICWISE] expression, cell migration and invasion, as well as the activation of erk1/2 and pi3k/akt, suggesting that erk1/2 and pi3k/akt activation occur downstream of egfr activation.
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we studied the significance of individual resource factors strengthening parents' resilience to [TOPICWISE] [TOPICWISE] distress, a focus that has rarely been used.
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thus, we demonstrate that [TOPICWISE] is a mediator of t cell dysfunction and an attractive [TOPICWISE] target to improve immune therapy responses.
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here, we analyzed the whole genomic, epigenomic, transcriptomic, and proteomic data of 155 esophageal squamous cell carcinomas ([TOPICWISE]).
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to date, a variety of [TOPICWISE] have been demonstrated to serve key functions in the progression and development of npc.
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it seems that nm is less [TOPICWISE] than ssm, for which other etiological and pathogenetic factors may play important roles.
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however, the effects and mechanisms by which [TOPICWISE]‑222 regulates liver tumorigenicity and confers sorafenib (sor) resistance remain unclear.
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we applied mechanical pressure of 10 mpa to chondrocytes for 60 minutes to establish the chondrocyte model of experimentally induced mechanical injury.
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novel [TOPICWISE] framework ([TOPICWISE]) was synthesized under optimal conditions of microwave with a power of 20 w, the temperature of 30 degrees of centigrade, and time duration of 10 min.
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mtt assay, wound healing assay and [TOPICWISE] assay were conducted to study cell proliferation, migration and invasion.
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the purpose of this research is to look at the special features of the [TOPICWISE], difficult, and highly nonlinear [TOPICWISE] model, with a particular focus on synchronization.
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pten, [TOPICWISE] and [TOPICWISE] protein expression levels were higher in adjacent normal tissues compared with those in tumor tissues.
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[TOPICWISE] ([TOPICWISE]) play pivotal roles in oa modulation, but the role of [TOPICWISE] in oa remains elusive.
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national institutes of health.
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in addition, [TOPICWISE] promoted the phosphorylation of pi3k and akt in bladder cancer cells.
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hence, the effects of gen on gc were investigated in our study.
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virus transduction, flow cytometry, immunofluorescence, [TOPICWISE], western blot, [TOPICWISE], tunel staining, and ao/eb staining were performed to explore the interactions between np cells and [TOPICWISE].7 macrophages.
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in multivariate analysis, [TOPICWISE] expression was [TOPICWISE] insignificant due to heavy correlation to disease stage and higher gradus.
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furthermore, antitumor assay indicated that [TOPICWISE]-treated [TOPICWISE] cells showed stronger cytotoxicity than those treated with cisplatin alone.
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the severity of this complication depends on the location of the tumour, the type of reconstruction, the total radiation dose, fractionation, and treatment techniques.
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solitary fibrous tumor/[TOPICWISE] is a new combined entity introduced in the 2016 world health organization classification of tumors of the central nervous system for grade [TOPICWISE] [TOPICWISE] tumors.
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second, as a consequence of genetic and epigenetic alterations, tumour cells express a series of proteins that are normally not present or present at lower levels.
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the relative expression of mirna-[TOPICWISE] in tissues and cultured cells was detected by quantitative real [TOPICWISE] chain reaction ([TOPICWISE]).
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mdm2 is the major negative regulator of the [TOPICWISE] pathway.
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the aim was to investigate [TOPICWISE] and red marrow absorbed doses in treatments of neuroblastoma (nb) and adult neuroendocrine tumors (nets) with (131)[TOPICWISE] and to propose a simple method for determining the activity to administer when dosimetric data for the individual patient are not available.
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general [TOPICWISE] was measured by the general [TOPICWISE] scale, [TOPICWISE] was measured with the [TOPICWISE], and stress was measured with the impact of event scale.
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age and the degree of adhesion between tumor and facial nerve were the risk factors for functional preservation of facial nerve 1 year after operation.
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subsequent functional experiments suggested that [TOPICWISE] decrement stimulated ec cells to grow and migrate.
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the knockdown of [TOPICWISE] repressed cell migration, invasion, and proliferation in [TOPICWISE] by sponging [TOPICWISE], which might offer a new therapeutic intervention for [TOPICWISE] patients.
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notably, [TOPICWISE] restoration abrogated the [TOPICWISE]-mediated suppression of proliferation, migration, and invasiveness of breast cancer cells.
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its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy.
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besides, tlr4 was predicted to be a firsthand direct target of [TOPICWISE]-[TOPICWISE].
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[TOPICWISE] and [TOPICWISE] agreement confirmed the reproducibility of the method.
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