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DS.d0
17003041
[ { "id": "DS.d0.s0", "text": [ "Bestrophin-1 enables Ca2+-activated Cl-conductance in epithelia." ], "offsets": [ [ 0, 64 ] ], "type": "" }, { "id": "DS.d0.s1", "text": [ "Calcium-dependent Cl (-) currents were activated by ATP in HEK293 cells expressing BEST1." ], "offsets": [ [ 65, 154 ] ], "type": "" } ]
[ { "id": "DS.d0.s0.e0", "type": "protein", "text": [ "Bestrophin-1" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O76090" }, { "db_name": "UniProt", "db_id": "O88870" }, { "db_name": "UniProt", "db_id": "Q21973" }, { "db_name": "UniProt", "db_id": "Q6UY87" }, { "db_name": "UniProt", "db_id": "Q8WMR7" } ] }, { "id": "DS.d0.s0.e1", "type": "compound", "text": [ "Cl" ], "offsets": [ [ 36, 38 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312" } ] }, { "id": "DS.d0.s1.e0", "type": "compound", "text": [ "Cl" ], "offsets": [ [ 83, 85 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312" } ] }, { "id": "DS.d0.s1.e1", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 117, 120 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d0.s1.e2", "type": "protein", "text": [ "BEST1" ], "offsets": [ [ 148, 153 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O76090" }, { "db_name": "UniProt", "db_id": "Q6UY87" }, { "db_name": "UniProt", "db_id": "Q8WMR7" } ] } ]
[]
[]
[ { "id": "DS.d0.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d0.s0.e1", "arg2_id": "DS.d0.s0.e0", "normalized": [] } ]
DS.d1
17321121
[ { "id": "DS.d1.s0", "text": [ "The absorption spectrum of the hydrogenase enzyme showed an absorption peak at 425nm indicating that the enzyme had iron-sulfur clusters." ], "offsets": [ [ 0, 137 ] ], "type": "" } ]
[ { "id": "DS.d1.s0.e0", "type": "protein", "text": [ "hydrogenase" ], "offsets": [ [ 31, 42 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P80509" }, { "db_name": "UniProt", "db_id": "P80510" } ] }, { "id": "DS.d1.s0.e1", "type": "compound", "text": [ "sulfur" ], "offsets": [ [ 121, 127 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "402" } ] } ]
[]
[]
[ { "id": "DS.d1.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1.s0.e1", "arg2_id": "DS.d1.s0.e0", "normalized": [] } ]
DS.d2
17403602
[ { "id": "DS.d2.s0", "text": [ "When Vitreoscilla were grown in medium containing 60mM sodium nitrite under both normal and limited aeration conditions, the levels of Vitreoscilla hemoglobin (VHb) were decreased by greater than 90%, while the levels of the terminal respiratory oxidase, cytochrome bo, were increased 350% under normal aeration and 7-23% under limited aeration." ], "offsets": [ [ 0, 345 ] ], "type": "" } ]
[ { "id": "DS.d2.s0.e0", "type": "compound", "text": [ "sodium nitrite" ], "offsets": [ [ 55, 69 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23668193" } ] }, { "id": "DS.d2.s0.e1", "type": "protein", "text": [ "hemoglobin" ], "offsets": [ [ 148, 158 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15160" }, { "db_name": "UniProt", "db_id": "P17724" }, { "db_name": "UniProt", "db_id": "P73925" }, { "db_name": "UniProt", "db_id": "Q03459" } ] } ]
[]
[]
[ { "id": "DS.d2.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d2.s0.e0", "arg2_id": "DS.d2.s0.e1", "normalized": [] } ]
DS.d3
17590240
[ { "id": "DS.d3.s0", "text": [ "Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation." ], "offsets": [ [ 0, 155 ] ], "type": "" }, { "id": "DS.d3.s1", "text": [ "Here, we used a human neuronal cell line MC65 conditional expression of an amyloid precursor protein fragment (APP-C99) to investigate the protection mechanism of epigallocatechin gallate (EGCG), the main constituent of green tea." ], "offsets": [ [ 156, 386 ] ], "type": "" } ]
[ { "id": "DS.d3.s0.e0", "type": "compound", "text": [ "Epigallocatechin gallate (EGCG" ], "offsets": [ [ 0, 30 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65064" } ] }, { "id": "DS.d3.s0.e1", "type": "protein", "text": [ "Abl" ], "offsets": [ [ 99, 102 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00520" }, { "db_name": "UniProt", "db_id": "P00522" } ] }, { "id": "DS.d3.s0.e2", "type": "protein", "text": [ "FE65" ], "offsets": [ [ 103, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00213" } ] }, { "id": "DS.d3.s0.e3", "type": "protein", "text": [ "GSK3 beta" ], "offsets": [ [ 134, 143 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P18266" }, { "db_name": "UniProt", "db_id": "P49841" }, { "db_name": "UniProt", "db_id": "Q5YJC2" }, { "db_name": "UniProt", "db_id": "Q9WV60" } ] }, { "id": "DS.d3.s1.e0", "type": "protein", "text": [ "APP-C99" ], "offsets": [ [ 267, 274 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P12023" } ] }, { "id": "DS.d3.s1.e1", "type": "compound", "text": [ "epigallocatechin gallate (EGCG" ], "offsets": [ [ 319, 349 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65064" } ] }, { "id": "DS.d3.s1.e2", "type": "compound", "text": [ "green tea" ], "offsets": [ [ 376, 385 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4630" } ] } ]
[]
[]
[ { "id": "DS.d3.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d3.s0.e0", "arg2_id": "DS.d3.s0.e3", "normalized": [] }, { "id": "DS.d3.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d3.s0.e0", "arg2_id": "DS.d3.s0.e1", "normalized": [] }, { "id": "DS.d3.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d3.s0.e0", "arg2_id": "DS.d3.s0.e2", "normalized": [] } ]
DS.d4
17616381
[ { "id": "DS.d4.s0", "text": [ "The protease was purified to homogeneity using ammonium sulfate precipitation, and ion exchange chromatography with a fold purification of 1.8 and a recovery of 49%." ], "offsets": [ [ 0, 165 ] ], "type": "" } ]
[ { "id": "DS.d4.s0.e0", "type": "protein", "text": [ "protease" ], "offsets": [ [ 4, 12 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O41798" }, { "db_name": "UniProt", "db_id": "O89290" }, { "db_name": "UniProt", "db_id": "O89940" }, { "db_name": "UniProt", "db_id": "O91080" }, { "db_name": "UniProt", "db_id": "O93215" }, { "db_name": "UniProt", "db_id": "P03311" }, { "db_name": "UniProt", "db_id": "P03353" }, { "db_name": "UniProt", "db_id": "P03355" }, { "db_name": "UniProt", "db_id": "P03356" }, { "db_name": "UniProt", "db_id": "P03362" }, { "db_name": "UniProt", "db_id": "P03363" }, { "db_name": "UniProt", "db_id": "P03366" }, { "db_name": "UniProt", "db_id": "P03367" }, { "db_name": "UniProt", "db_id": "P03369" }, { "db_name": "UniProt", "db_id": "P03370" }, { "db_name": "UniProt", "db_id": "P04023" }, { "db_name": "UniProt", "db_id": "P04024" }, { "db_name": "UniProt", "db_id": "P04323" }, { "db_name": "UniProt", "db_id": "P04584" }, { "db_name": "UniProt", "db_id": "P04585" }, { "db_name": "UniProt", "db_id": "P04587" }, { "db_name": "UniProt", "db_id": "P04588" }, { "db_name": "UniProt", "db_id": "P04589" }, { "db_name": "UniProt", "db_id": "P05959" }, { "db_name": "UniProt", "db_id": "P05960" }, { "db_name": "UniProt", "db_id": "P05961" }, { "db_name": "UniProt", "db_id": "P05962" }, { "db_name": "UniProt", "db_id": "P07570" }, { "db_name": "UniProt", "db_id": "P0C210" }, { "db_name": "UniProt", "db_id": "P0C211" }, { "db_name": "UniProt", "db_id": "P10210" }, { "db_name": "UniProt", "db_id": "P10265" }, { "db_name": "UniProt", "db_id": "P10270" }, { "db_name": "UniProt", "db_id": "P10271" }, { "db_name": "UniProt", "db_id": "P10272" }, { "db_name": "UniProt", "db_id": "P10273" }, { "db_name": "UniProt", "db_id": "P10274" }, { "db_name": "UniProt", "db_id": "P10394" }, { "db_name": "UniProt", "db_id": "P10978" }, { "db_name": "UniProt", "db_id": "P11227" }, { "db_name": "UniProt", "db_id": "P11365" }, { "db_name": "UniProt", "db_id": "P12451" }, { "db_name": "UniProt", "db_id": "P12497" }, { "db_name": "UniProt", "db_id": "P12498" }, { "db_name": "UniProt", "db_id": "P12499" }, { "db_name": "UniProt", "db_id": "P14074" }, { "db_name": "UniProt", "db_id": "P14078" }, { "db_name": "UniProt", "db_id": "P15833" }, { "db_name": "UniProt", "db_id": "P16046" }, { "db_name": "UniProt", "db_id": "P16423" }, { "db_name": "UniProt", "db_id": "P16901" }, { "db_name": "UniProt", "db_id": "P17757" }, { "db_name": "UniProt", "db_id": "P18042" }, { "db_name": "UniProt", "db_id": "P18096" }, { "db_name": "UniProt", "db_id": "P18802" }, { "db_name": "UniProt", "db_id": "P19028" }, { "db_name": "UniProt", "db_id": "P19199" }, { "db_name": "UniProt", "db_id": "P19560" }, { "db_name": "UniProt", "db_id": "P19561" }, { "db_name": "UniProt", "db_id": "P20825" }, { "db_name": "UniProt", "db_id": "P20875" }, { "db_name": "UniProt", "db_id": "P20876" }, { "db_name": "UniProt", "db_id": "P20892" }, { "db_name": "UniProt", "db_id": "P21407" }, { "db_name": "UniProt", "db_id": "P21414" }, { "db_name": "UniProt", "db_id": "P24107" }, { "db_name": "UniProt", "db_id": "P24740" }, { "db_name": "UniProt", "db_id": "P26808" }, { "db_name": "UniProt", "db_id": "P26809" }, { "db_name": "UniProt", "db_id": "P26810" }, { "db_name": "UniProt", "db_id": "P27502" }, { "db_name": "UniProt", "db_id": "P28936" }, { "db_name": "UniProt", "db_id": "P31822" }, { "db_name": "UniProt", "db_id": "P35956" }, { "db_name": "UniProt", "db_id": "P35963" }, { "db_name": "UniProt", "db_id": "P51518" }, { "db_name": "UniProt", "db_id": "P63119" }, { "db_name": "UniProt", "db_id": "P63120" }, { "db_name": "UniProt", "db_id": "P63121" }, { "db_name": "UniProt", "db_id": "P63122" }, { "db_name": "UniProt", "db_id": "P63123" }, { "db_name": "UniProt", "db_id": "P63124" }, { "db_name": "UniProt", "db_id": "P63125" }, { "db_name": "UniProt", "db_id": "P63127" }, { "db_name": "UniProt", "db_id": "P63128" }, { "db_name": "UniProt", "db_id": "P63129" }, { "db_name": "UniProt", "db_id": "P63131" }, { "db_name": "UniProt", "db_id": "P84454" }, { "db_name": "UniProt", "db_id": "Q09SZ9" }, { "db_name": "UniProt", "db_id": "Q0R5R2" }, { "db_name": "UniProt", "db_id": "Q0R5R3" }, { "db_name": "UniProt", "db_id": "Q1A249" }, { "db_name": "UniProt", "db_id": "Q1A267" }, { "db_name": "UniProt", "db_id": "Q4U0X6" }, { "db_name": "UniProt", "db_id": "Q73368" }, { "db_name": "UniProt", "db_id": "Q74120" }, { "db_name": "UniProt", "db_id": "Q75002" }, { "db_name": "UniProt", "db_id": "Q76634" }, { "db_name": "UniProt", "db_id": "Q77373" }, { "db_name": "UniProt", "db_id": "Q79666" }, { "db_name": "UniProt", "db_id": "Q89928" }, { "db_name": "UniProt", "db_id": "Q8AII1" }, { "db_name": "UniProt", "db_id": "Q8I7P9" }, { "db_name": "UniProt", "db_id": "Q9IDV9" }, { "db_name": "UniProt", "db_id": "Q9Q720" }, { "db_name": "UniProt", "db_id": "Q9QBY3" }, { "db_name": "UniProt", "db_id": "Q9QBZ1" }, { "db_name": "UniProt", "db_id": "Q9QBZ5" }, { "db_name": "UniProt", "db_id": "Q9QSR3" }, { "db_name": "UniProt", "db_id": "Q9WC54" }, { "db_name": "UniProt", "db_id": "Q9WC63" }, { "db_name": "UniProt", "db_id": "Q9Y6I0" } ] }, { "id": "DS.d4.s0.e1", "type": "compound", "text": [ "ammonium" ], "offsets": [ [ 47, 55 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "223" } ] }, { "id": "DS.d4.s0.e2", "type": "compound", "text": [ "sulfate" ], "offsets": [ [ 56, 63 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1117" } ] } ]
[]
[]
[]
DS.d5
17629591
[ { "id": "DS.d5.s0", "text": [ "In addition, we demonstrated that Hsp20, HspB2 and HspB8 induced interleukin-6 production in cultured pericytes and astrocytes, which could be antagonized by dexamethasone, whereas other sHsps and A beta were inactive, suggesting that sHsps may be among the key mediators of the local inflammatory response associated with HCHWA-D and AD lesions." ], "offsets": [ [ 0, 346 ] ], "type": "" } ]
[ { "id": "DS.d5.s0.e0", "type": "protein", "text": [ "HspB2" ], "offsets": [ [ 41, 46 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35878" }, { "db_name": "UniProt", "db_id": "Q16082" }, { "db_name": "UniProt", "db_id": "Q99PR8" } ] }, { "id": "DS.d5.s0.e1", "type": "protein", "text": [ "HspB8" ], "offsets": [ [ 51, 56 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q5EAC9" }, { "db_name": "UniProt", "db_id": "Q5RAB0" }, { "db_name": "UniProt", "db_id": "Q6SJQ8" }, { "db_name": "UniProt", "db_id": "Q8MJ36" }, { "db_name": "UniProt", "db_id": "Q9EPX0" }, { "db_name": "UniProt", "db_id": "Q9JK92" }, { "db_name": "UniProt", "db_id": "Q9UJY1" } ] }, { "id": "DS.d5.s0.e2", "type": "protein", "text": [ "interleukin-6" ], "offsets": [ [ 65, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d5.s0.e3", "type": "compound", "text": [ "dexamethasone" ], "offsets": [ [ 158, 171 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5743" } ] } ]
[]
[]
[ { "id": "DS.d5.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d5.s0.e3", "arg2_id": "DS.d5.s0.e2", "normalized": [] } ]
DS.d6
17692997
[ { "id": "DS.d6.s0", "text": [ "Furthermore, dithiothreitol was found to be capable of significantly preventing the inhibitory effect of insulin on Abeta oligomer formation." ], "offsets": [ [ 0, 141 ] ], "type": "" } ]
[ { "id": "DS.d6.s0.e0", "type": "compound", "text": [ "dithiothreitol" ], "offsets": [ [ 13, 27 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "19001" }, { "db_name": "PubChem", "db_id": "439196" }, { "db_name": "PubChem", "db_id": "446094" } ] }, { "id": "DS.d6.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 105, 112 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[ { "id": "DS.d6.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d6.s0.e0", "arg2_id": "DS.d6.s0.e1", "normalized": [] } ]
DS.d7
17719144
[ { "id": "DS.d7.s0", "text": [ "The scavenger receptor, class B, type I (SR-BI) is critical in maintaining the homeostasis of cholesterol and alpha-tocopherol." ], "offsets": [ [ 0, 127 ] ], "type": "" }, { "id": "DS.d7.s1", "text": [ "SR-BI binds high-density lipoproteins (HDL) and mediates the selective transfer of cholesteryl esters and alpha-tocopherol from circulating HDL to cells." ], "offsets": [ [ 128, 281 ] ], "type": "" }, { "id": "DS.d7.s2", "text": [ "Thus, SR-BI influences neural and cognitive processes, a finding that highlights the contribution of cholesterol and alpha-tocopherol homeostasis in proper cognitive function." ], "offsets": [ [ 282, 457 ] ], "type": "" } ]
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[]
[]
[ { "id": "DS.d7.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d7.s0.e3", "arg2_id": "DS.d7.s0.e1", "normalized": [] }, { "id": "DS.d7.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d7.s0.e2", "arg2_id": "DS.d7.s0.e1", "normalized": [] }, { "id": "DS.d7.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d7.s1.e2", "arg2_id": "DS.d7.s1.e0", "normalized": [] } ]
DS.d8
17768029
[ { "id": "DS.d8.s0", "text": [ "Alloxan is believed to confer its diabetogenic effect by inhibiting pancreatic glucokinase activity, leading to pancreatic beta-cell death." ], "offsets": [ [ 0, 139 ] ], "type": "" } ]
[ { "id": "DS.d8.s0.e0", "type": "compound", "text": [ "Alloxan" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5781" } ] }, { "id": "DS.d8.s0.e1", "type": "protein", "text": [ "glucokinase" ], "offsets": [ [ 79, 90 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O25731" }, { "db_name": "UniProt", "db_id": "P0A4E1" }, { "db_name": "UniProt", "db_id": "P0A4E2" }, { "db_name": "UniProt", "db_id": "P0A6V8" }, { "db_name": "UniProt", "db_id": "P0A6V9" }, { "db_name": "UniProt", "db_id": "P17712" }, { "db_name": "UniProt", "db_id": "P21908" }, { "db_name": "UniProt", "db_id": "P35557" }, { "db_name": "UniProt", "db_id": "P52792" }, { "db_name": "UniProt", "db_id": "P54495" }, { "db_name": "UniProt", "db_id": "P58616" }, { "db_name": "UniProt", "db_id": "P58617" }, { "db_name": "UniProt", "db_id": "P58618" }, { "db_name": "UniProt", "db_id": "P58619" }, { "db_name": "UniProt", "db_id": "P64253" }, { "db_name": "UniProt", "db_id": "P64254" }, { "db_name": "UniProt", "db_id": "P82680" }, { "db_name": "UniProt", "db_id": "Q55855" }, { "db_name": "UniProt", "db_id": "Q56198" }, { "db_name": "UniProt", "db_id": "Q59171" }, { "db_name": "UniProt", "db_id": "Q668N7" }, { "db_name": "UniProt", "db_id": "Q6D7C4" }, { "db_name": "UniProt", "db_id": "Q7N6Y0" }, { "db_name": "UniProt", "db_id": "Q83K86" }, { "db_name": "UniProt", "db_id": "Q87EG6" }, { "db_name": "UniProt", "db_id": "Q8FFD4" }, { "db_name": "UniProt", "db_id": "Q8FV09" }, { "db_name": "UniProt", "db_id": "Q8P8U7" }, { "db_name": "UniProt", "db_id": "Q8PKU2" }, { "db_name": "UniProt", "db_id": "Q8UIV7" }, { "db_name": "UniProt", "db_id": "Q8YDC6" }, { "db_name": "UniProt", "db_id": "Q92407" }, { "db_name": "UniProt", "db_id": "Q92T27" }, { "db_name": "UniProt", "db_id": "Q93IM5" }, { "db_name": "UniProt", "db_id": "Q98DM2" }, { "db_name": "UniProt", "db_id": "Q9A6N3" }, { "db_name": "UniProt", "db_id": "Q9HZ46" }, { "db_name": "UniProt", "db_id": "Q9KCZ4" }, { "db_name": "UniProt", "db_id": "Q9PEG4" }, { "db_name": "UniProt", "db_id": "Q9ZKB0" } ] } ]
[]
[]
[ { "id": "DS.d8.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d8.s0.e0", "arg2_id": "DS.d8.s0.e1", "normalized": [] } ]
DS.d9
17882129
[ { "id": "DS.d9.s0", "text": [ "Alpha-tocopherol supplementation prevents the exercise-induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals." ], "offsets": [ [ 0, 143 ] ], "type": "" } ]
[ { "id": "DS.d9.s0.e0", "type": "compound", "text": [ "Alpha-tocopherol" ], "offsets": [ [ 0, 16 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" } ] }, { "id": "DS.d9.s0.e1", "type": "protein", "text": [ "arylesterase" ], "offsets": [ [ 96, 108 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22862" } ] } ]
[]
[]
[ { "id": "DS.d9.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d9.s0.e0", "arg2_id": "DS.d9.s0.e1", "normalized": [] } ]
DS.d10
17888544
[ { "id": "DS.d10.s0", "text": [ "Although ApoE4 has been repeatedly associated with altered sphingomyelin and cholesterol levels in tissue culture and rodent models, there has not been a direct quantification of sphingomyelin or sterol levels in the brains of patients with different forms of ApoE." ], "offsets": [ [ 0, 265 ] ], "type": "" } ]
[ { "id": "DS.d10.s0.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 77, 88 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d10.s0.e1", "type": "protein", "text": [ "ApoE" ], "offsets": [ [ 9, 13 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02649" }, { "db_name": "UniProt", "db_id": "P02650" }, { "db_name": "UniProt", "db_id": "P05770" }, { "db_name": "UniProt", "db_id": "P08226" }, { "db_name": "UniProt", "db_id": "P10517" }, { "db_name": "UniProt", "db_id": "P18287" }, { "db_name": "UniProt", "db_id": "P18649" }, { "db_name": "UniProt", "db_id": "P18650" }, { "db_name": "UniProt", "db_id": "P23529" }, { "db_name": "UniProt", "db_id": "Q03247" }, { "db_name": "UniProt", "db_id": "Q28502" }, { "db_name": "UniProt", "db_id": "Q28995" }, { "db_name": "UniProt", "db_id": "Q7M2U7" }, { "db_name": "UniProt", "db_id": "Q7M2U8" }, { "db_name": "UniProt", "db_id": "Q9GJU3" }, { "db_name": "UniProt", "db_id": "Q9GLC0" }, { "db_name": "UniProt", "db_id": "Q9GLM6" }, { "db_name": "UniProt", "db_id": "Q9GLM7" }, { "db_name": "UniProt", "db_id": "Q9GLM8" } ] } ]
[]
[]
[ { "id": "DS.d10.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d10.s0.e0", "arg2_id": "DS.d10.s0.e1", "normalized": [] } ]
DS.d11
17888546
[ { "id": "DS.d11.s0", "text": [ "ApoE modified the association between cholesterol and cognitive decline, and the association between the ratio of 27-hydroxycholesterol to cholesterol and cognitive functioning." ], "offsets": [ [ 0, 177 ] ], "type": "" } ]
[ { "id": "DS.d11.s0.e0", "type": "protein", "text": [ "ApoE" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02649" }, { "db_name": "UniProt", "db_id": "P02650" }, { "db_name": "UniProt", "db_id": "P05770" }, { "db_name": "UniProt", "db_id": "P08226" }, { "db_name": "UniProt", "db_id": "P10517" }, { "db_name": "UniProt", "db_id": "P18287" }, { "db_name": "UniProt", "db_id": "P18649" }, { "db_name": "UniProt", "db_id": "P18650" }, { "db_name": "UniProt", "db_id": "P23529" }, { "db_name": "UniProt", "db_id": "Q03247" }, { "db_name": "UniProt", "db_id": "Q28502" }, { "db_name": "UniProt", "db_id": "Q28995" }, { "db_name": "UniProt", "db_id": "Q7M2U7" }, { "db_name": "UniProt", "db_id": "Q7M2U8" }, { "db_name": "UniProt", "db_id": "Q9GJU3" }, { "db_name": "UniProt", "db_id": "Q9GLC0" }, { "db_name": "UniProt", "db_id": "Q9GLM6" }, { "db_name": "UniProt", "db_id": "Q9GLM7" }, { "db_name": "UniProt", "db_id": "Q9GLM8" } ] }, { "id": "DS.d11.s0.e1", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 38, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d11.s0.e2", "type": "compound", "text": [ "27-hydroxycholesterol" ], "offsets": [ [ 114, 135 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "99470" }, { "db_name": "PubChem", "db_id": "123976" }, { "db_name": "PubChem", "db_id": "50990021" } ] }, { "id": "DS.d11.s0.e3", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 124, 135 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]
[]
[]
[ { "id": "DS.d11.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d11.s0.e2", "arg2_id": "DS.d11.s0.e0", "normalized": [] }, { "id": "DS.d11.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d11.s0.e1", "arg2_id": "DS.d11.s0.e0", "normalized": [] } ]
DS.d12
17890844
[ { "id": "DS.d12.s0", "text": [ "Here we show that during growth in media containing glucose and in complex medium without glucose RamB activates expression of the aceE gene, encoding the E1p subunit of the pyruvate dehydrogenase complex." ], "offsets": [ [ 0, 205 ] ], "type": "" } ]
[ { "id": "DS.d12.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 52, 59 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d12.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 90, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d12.s0.e2", "type": "protein", "text": [ "aceE" ], "offsets": [ [ 131, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0AFG8" }, { "db_name": "UniProt", "db_id": "P0AFG9" }, { "db_name": "UniProt", "db_id": "P45119" }, { "db_name": "UniProt", "db_id": "P57301" }, { "db_name": "UniProt", "db_id": "Q10504" }, { "db_name": "UniProt", "db_id": "Q59637" }, { "db_name": "UniProt", "db_id": "Q89AR0" }, { "db_name": "UniProt", "db_id": "Q8K9T9" } ] } ]
[]
[]
[]
DS.d13
17925795
[ { "id": "DS.d13.s0", "text": [ "The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons." ], "offsets": [ [ 0, 128 ] ], "type": "" }, { "id": "DS.d13.s1", "text": [ "Treatment of cultured rat cortical neurons with therapeutic concentrations of LiCl or VPA selectively increased the levels of exon IV (formerly rat exon III)-containing BDNF mRNA, and the activity of BDNF promoter IV." ], "offsets": [ [ 129, 346 ] ], "type": "" }, { "id": "DS.d13.s2", "text": [ "We showed that lithium-induced activation of promoter IV was mimicked by pharmacological inhibition of GSK-3 or short interfering RNA (siRNA)-mediated gene silencing of GSK-3alpha or GSK-3beta isoforms." ], "offsets": [ [ 347, 549 ] ], "type": "" }, { "id": "DS.d13.s3", "text": [ "Furthermore, treatment with other HDAC inhibitors, sodium butyrate and trichostatin A, or transfection with an HDAC1-specific siRNA also activated BDNF promoter IV." ], "offsets": [ [ 550, 714 ] ], "type": "" }, { "id": "DS.d13.s4", "text": [ "Our study demonstrates for the first time that GSK-3 and HDAC are respective initial targets for lithium and VPA to activate BDNF promoter IV, and that this BDNF induction involves a novel responsive region in promoter IV of the BDNF gene." ], "offsets": [ [ 715, 954 ] ], "type": "" } ]
[ { "id": "DS.d13.s0.e0", "type": "compound", "text": [ "lithium" ], "offsets": [ [ 21, 28 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "28486" }, { "db_name": "PubChem", "db_id": "3028194" } ] }, { "id": "DS.d13.s0.e1", "type": "compound", "text": [ "valproate" ], "offsets": [ [ 33, 42 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3121" } ] }, { "id": "DS.d13.s0.e2", "type": "protein", "text": [ "brain-derived neurotrophic factor" ], "offsets": [ [ 83, 116 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q06225" } ] }, { "id": "DS.d13.s1.e0", "type": "compound", "text": [ "LiCl" ], "offsets": [ [ 207, 211 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "433294" } ] }, { "id": "DS.d13.s1.e1", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 298, 302 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": 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[]
[]
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DS.d14
17941873
[ { "id": "DS.d14.s0", "text": [ "Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type 2 diabetes mellitus: The ACTION Study (Achieving Control Through Insulin plus Oral ageNts)." ], "offsets": [ [ 0, 188 ] ], "type": "" }, { "id": "DS.d14.s1", "text": [ "Efficacy and safety of biphasic insulin aspart (BIAsp 30, 30% short-acting and 70% intermediate-acting insulin aspart) added to an optimized treatment of metformin and pioglitazone (met/pio) were compared with treatment with optimized met/pio in type 2 diabetes patients." ], "offsets": [ [ 189, 460 ] ], "type": "" } ]
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}, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d14.s1.e2", "type": "compound", "text": [ "metformin" ], "offsets": [ [ 343, 352 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4091" } ] }, { "id": "DS.d14.s1.e3", "type": "compound", "text": [ "pioglitazone" ], "offsets": [ [ 357, 369 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4829" } ] } ]
[]
[]
[]
DS.d15
17943458
[ { "id": "DS.d15.s0", "text": [ "N-acetylaspartic acid (NAA) is converted into aspartate and acetate by aspartoacylase." ], "offsets": [ [ 0, 86 ] ], "type": "" } ]
[ { "id": "DS.d15.s0.e0", "type": "compound", "text": [ "N-acetylaspartic acid" ], "offsets": [ [ 0, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65065" } ] }, { "id": "DS.d15.s0.e1", "type": "compound", "text": [ "aspartate" ], "offsets": [ [ 46, 55 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5960" } ] }, { "id": "DS.d15.s0.e2", "type": "compound", "text": [ "acetate" ], "offsets": [ [ 60, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "53627460" } ] }, { "id": "DS.d15.s0.e3", "type": "protein", "text": [ "aspartoacylase" ], "offsets": [ [ 71, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P45381" }, { "db_name": "UniProt", "db_id": "P46446" }, { "db_name": "UniProt", "db_id": "Q60HH2" }, { "db_name": "UniProt", "db_id": "Q8R3P0" }, { "db_name": "UniProt", "db_id": "Q9R1T5" } ] } ]
[]
[]
[ { "id": "DS.d15.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d15.s0.e0", "arg2_id": "DS.d15.s0.e3", "normalized": [] }, { "id": "DS.d15.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d15.s0.e1", "arg2_id": "DS.d15.s0.e3", "normalized": [] }, { "id": "DS.d15.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d15.s0.e2", "arg2_id": "DS.d15.s0.e3", "normalized": [] } ]
DS.d16
17950491
[ { "id": "DS.d16.s0", "text": [ "In addition, treatment with rosiglitazone increased interleukin-4 (IL-4) mRNA and reversed the age-related decrease in hippocampal IL-4 concentration." ], "offsets": [ [ 0, 150 ] ], "type": "" } ]
[ { "id": "DS.d16.s0.e0", "type": "compound", "text": [ "rosiglitazone" ], "offsets": [ [ 28, 41 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "77999" } ] }, { "id": "DS.d16.s0.e1", "type": "protein", "text": [ "IL-4" ], "offsets": [ [ 67, 71 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77762" }, { "db_name": "UniProt", "db_id": "P05112" }, { "db_name": "UniProt", "db_id": "P07750" }, { "db_name": "UniProt", "db_id": "P20096" }, { "db_name": "UniProt", "db_id": "P30367" }, { "db_name": "UniProt", "db_id": "P30368" }, { "db_name": "UniProt", "db_id": "P42202" }, { "db_name": "UniProt", "db_id": "P46652" }, { "db_name": "UniProt", "db_id": "P47966" }, { "db_name": "UniProt", "db_id": "P51492" }, { "db_name": "UniProt", "db_id": "P51744" }, { "db_name": "UniProt", "db_id": "P55030" }, { "db_name": "UniProt", "db_id": "P79155" }, { "db_name": "UniProt", "db_id": "P79339" }, { "db_name": "UniProt", "db_id": "Q04745" }, { "db_name": "UniProt", "db_id": "Q2PE74" }, { "db_name": "UniProt", "db_id": "Q3S4V6" }, { "db_name": "UniProt", "db_id": "Q58M18" }, { "db_name": "UniProt", "db_id": "Q60440" }, { "db_name": "UniProt", "db_id": "Q7YS71" }, { "db_name": "UniProt", "db_id": "Q865X5" }, { "db_name": "UniProt", "db_id": "Q865Y0" }, { "db_name": "UniProt", "db_id": "Q8HYB1" }, { "db_name": "UniProt", "db_id": "Q9MZR8" }, { "db_name": "UniProt", "db_id": "Q9XS58" } ] }, { "id": "DS.d16.s0.e2", "type": "protein", "text": [ "IL-4" ], "offsets": [ [ 131, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77762" }, { "db_name": "UniProt", "db_id": "P05112" }, { "db_name": "UniProt", "db_id": "P07750" }, { "db_name": "UniProt", "db_id": "P20096" }, { "db_name": "UniProt", "db_id": "P30367" }, { "db_name": "UniProt", "db_id": "P30368" }, { "db_name": "UniProt", "db_id": "P42202" }, { "db_name": "UniProt", "db_id": "P46652" }, { "db_name": "UniProt", "db_id": "P47966" }, { "db_name": "UniProt", "db_id": "P51492" }, { "db_name": "UniProt", "db_id": "P51744" }, { "db_name": "UniProt", "db_id": "P55030" }, { "db_name": "UniProt", "db_id": "P79155" }, { "db_name": "UniProt", "db_id": "P79339" }, { "db_name": "UniProt", "db_id": "Q04745" }, { "db_name": "UniProt", "db_id": "Q2PE74" }, { "db_name": "UniProt", "db_id": "Q3S4V6" }, { "db_name": "UniProt", "db_id": "Q58M18" }, { "db_name": "UniProt", "db_id": "Q60440" }, { "db_name": "UniProt", "db_id": "Q7YS71" }, { "db_name": "UniProt", "db_id": "Q865X5" }, { "db_name": "UniProt", "db_id": "Q865Y0" }, { "db_name": "UniProt", "db_id": "Q8HYB1" }, { "db_name": "UniProt", "db_id": "Q9MZR8" }, { "db_name": "UniProt", "db_id": "Q9XS58" } ] } ]
[]
[]
[ { "id": "DS.d16.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d16.s0.e0", "arg2_id": "DS.d16.s0.e1", "normalized": [] } ]
DS.d17
17965987
[ { "id": "DS.d17.s0", "text": [ "Serum BDNF levels were increased and plasma levels of HVA and MHPG were decreased according to the recovery from the active phase of the disease." ], "offsets": [ [ 0, 145 ] ], "type": "" }, { "id": "DS.d17.s1", "text": [ "These results suggest that dysfunctions of catecholaminergic neurons and neurotrophic factors might exist in Sydenham's chorea, and the decreasing catecholamine activities in response to risperidone might be associated with the improvement of the disease." ], "offsets": [ [ 146, 401 ] ], "type": "" } ]
[ { "id": "DS.d17.s0.e0", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 6, 10 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d17.s0.e1", "type": "compound", "text": [ "HVA" ], "offsets": [ [ 54, 57 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1738" } ] }, { "id": "DS.d17.s0.e2", "type": "compound", "text": [ "MHPG" ], "offsets": [ [ 62, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10805" } ] }, { "id": "DS.d17.s1.e0", "type": "protein", "text": [ "neurotrophic factors" ], "offsets": [ [ 219, 239 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P18280" }, { "db_name": "UniProt", "db_id": "P20181" }, { "db_name": "UniProt", "db_id": "P20783" }, { "db_name": "UniProt", "db_id": "P25433" }, { "db_name": "UniProt", "db_id": "P25434" }, { "db_name": "UniProt", "db_id": "P25435" }, { "db_name": "UniProt", "db_id": "Q9TST2" } ] }, { "id": "DS.d17.s1.e1", "type": "compound", "text": [ "risperidone" ], "offsets": [ [ 333, 344 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5073" } ] } ]
[]
[]
[]
DS.d18
17968352
[ { "id": "DS.d18.s0", "text": [ "Based on these validities we identified alterations in the Wolframin gene in the CA1 and amygdala regions, specifically in exposed PTSD-like rats, which were normalized after treatment with citalopram." ], "offsets": [ [ 0, 201 ] ], "type": "" } ]
[ { "id": "DS.d18.s0.e0", "type": "protein", "text": [ "Wolframin" ], "offsets": [ [ 59, 68 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O76024" }, { "db_name": "UniProt", "db_id": "P56695" } ] }, { "id": "DS.d18.s0.e1", "type": "compound", "text": [ "citalopram" ], "offsets": [ [ 190, 200 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2771" }, { "db_name": "PubChem", "db_id": "146570" } ] } ]
[]
[]
[ { "id": "DS.d18.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d18.s0.e1", "arg2_id": "DS.d18.s0.e0", "normalized": [] } ]
DS.d19
17968676
[ { "id": "DS.d19.s0", "text": [ "Cyclooxygenase-2 (Cox-2) is a key enzyme in the conversion of arachidonic acid to prostaglandins that has been shown to have a particular importance in the progression of several malignancies including nasopharyngeal carcinoma (NPC)." ], "offsets": [ [ 0, 233 ] ], "type": "" } ]
[ { "id": "DS.d19.s0.e0", "type": "protein", "text": [ "Cyclooxygenase-2" ], "offsets": [ [ 0, 16 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d19.s0.e1", "type": "protein", "text": [ "Cox-2" ], "offsets": [ [ 18, 23 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00411" }, { "db_name": "UniProt", "db_id": "P24894" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "Q05769" }, { "db_name": "UniProt", "db_id": "Q8HEC3" }, { "db_name": "UniProt", "db_id": "Q8SEM9" } ] }, { "id": "DS.d19.s0.e2", "type": "compound", "text": [ "arachidonic acid" ], "offsets": [ [ 62, 78 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444899" } ] } ]
[]
[]
[ { "id": "DS.d19.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d19.s0.e2", "arg2_id": "DS.d19.s0.e0", "normalized": [] }, { "id": "DS.d19.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d19.s0.e2", "arg2_id": "DS.d19.s0.e1", "normalized": [] } ]
DS.d20
17976762
[ { "id": "DS.d20.s0", "text": [ "Other potential treatments discussed for possible use with long-acting insulin overdoses include incision and drainage of the injection site, glucagon, and octreotide." ], "offsets": [ [ 0, 167 ] ], "type": "" } ]
[ { "id": "DS.d20.s0.e0", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 71, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d20.s0.e2", "type": "compound", "text": [ "octreotide" ], "offsets": [ [ 156, 166 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "383414" }, { "db_name": "PubChem", "db_id": "448601" } ] } ]
[]
[]
[]
DS.d21
18037312
[ { "id": "DS.d21.s0", "text": [ "Cadmium inhalation induced: (1) a transient bronchial inflammation, dominated by neutrophils; (2) a neutrophilia of the blood that persisted for up to 4 weeks; (3) a transient increased bronchial reactivity, and (4) a significant increase in MMP-9 activity in the BALF." ], "offsets": [ [ 0, 269 ] ], "type": "" } ]
[ { "id": "DS.d21.s0.e0", "type": "compound", "text": [ "Cadmium" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23973" } ] }, { "id": "DS.d21.s0.e1", "type": "protein", "text": [ "MMP-9" ], "offsets": [ [ 242, 247 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18733" }, { "db_name": "UniProt", "db_id": "P14780" }, { "db_name": "UniProt", "db_id": "P41245" }, { "db_name": "UniProt", "db_id": "P41246" }, { "db_name": "UniProt", "db_id": "P50282" }, { "db_name": "UniProt", "db_id": "P52176" } ] } ]
[]
[]
[ { "id": "DS.d21.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d21.s0.e0", "arg2_id": "DS.d21.s0.e1", "normalized": [] } ]
DS.d22
18042181
[ { "id": "DS.d22.s0", "text": [ "To assess whether follicle-stimulating hormone (FSH) and basic fibroblast growth factor (bFGF) modulate GSH production in Sertoli cells by regulating the expression of GCLC, GCLM and/or GR, we performed in vitro studies using rat Sertoli cells in primary culture." ], "offsets": [ [ 0, 263 ] ], "type": "" }, { "id": "DS.d22.s1", "text": [ "In conclusion, our results show that FSH and bFGF increase GSH levels in Sertoli cells through stimulation of the de novo synthesis and recycling by upregulating GCLM and GR expression respectively." ], "offsets": [ [ 264, 462 ] ], "type": "" } ]
[ { "id": "DS.d22.s0.e0", "type": "protein", "text": [ "basic fibroblast growth factor" ], "offsets": [ [ 57, 87 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03969" }, { "db_name": "UniProt", "db_id": "P09038" }, { "db_name": "UniProt", "db_id": "P12226" }, { "db_name": "UniProt", "db_id": "P13109" }, { "db_name": "UniProt", "db_id": "P15655" }, { "db_name": "UniProt", "db_id": "P20003" }, { "db_name": "UniProt", "db_id": "P48798" }, { "db_name": "UniProt", "db_id": "P48799" }, { "db_name": "UniProt", "db_id": "P48800" }, { "db_name": "UniProt", "db_id": "Q60487" } ] }, { "id": "DS.d22.s0.e1", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 104, 107 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d22.s0.e2", "type": "protein", "text": [ "GCLC" ], "offsets": [ [ 168, 172 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P48506" } ] }, { "id": "DS.d22.s0.e3", "type": "protein", "text": [ "GCLM" ], "offsets": [ [ 174, 178 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P48507" }, { "db_name": "UniProt", "db_id": "Q2T9Y6" } ] }, { "id": "DS.d22.s1.e0", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 323, 326 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d22.s1.e1", "type": "protein", "text": [ "GCLM" ], "offsets": [ [ 426, 430 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P48507" }, { "db_name": "UniProt", "db_id": "Q2T9Y6" } ] } ]
[]
[]
[]
DS.d23
18061671
[ { "id": "DS.d23.s0", "text": [ "Compared to the control, both the stresses individually and in combination led to in reductions in growth, photosynthetic pigments, ascorbic acid, catalase (CAT) activity and yield, whereas a reverse trend was observed for flavonoids, thiols and proline contents, superoxide dismutase (SOD) and peroxidase (POD) activities, and LPO." ], "offsets": [ [ 0, 332 ] ], "type": "" } ]
[ { "id": "DS.d23.s0.e0", "type": "compound", "text": [ "ascorbic acid" ], "offsets": [ [ 132, 145 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54670067" }, { "db_name": "PubChem", "db_id": "54690394" } ] }, { "id": "DS.d23.s0.e1", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 147, 155 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] }, { "id": "DS.d23.s0.e2", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 157, 160 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P00485" }, { "db_name": "UniProt", "db_id": "P00486" }, { "db_name": "UniProt", "db_id": "P00487" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P06135" }, { "db_name": "UniProt", "db_id": "P07641" }, { "db_name": "UniProt", "db_id": "P11504" }, { "db_name": "UniProt", "db_id": "P20074" }, { "db_name": "UniProt", "db_id": "P22782" }, { "db_name": "UniProt", "db_id": "P25309" }, { "db_name": "UniProt", "db_id": "P25819" }, { "db_name": "UniProt", "db_id": "P26825" }, { "db_name": "UniProt", "db_id": "P26826" }, { "db_name": "UniProt", "db_id": "P32796" }, { "db_name": "UniProt", "db_id": "P36882" }, { "db_name": "UniProt", "db_id": "P36883" }, { "db_name": "UniProt", "db_id": "P43155" }, { "db_name": "UniProt", "db_id": "P47934" }, { "db_name": "UniProt", "db_id": "P49417" }, { "db_name": "UniProt", "db_id": "P52826" }, { "db_name": "UniProt", "db_id": "P58777" }, { "db_name": "UniProt", "db_id": "P62577" }, { "db_name": "UniProt", "db_id": "P62578" }, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] }, { "id": "DS.d23.s0.e3", "type": "compound", "text": [ "proline" ], "offsets": [ [ 246, 253 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "614" }, { "db_name": "PubChem", "db_id": "8988" }, { "db_name": "PubChem", "db_id": "145742" } ] }, { "id": "DS.d23.s0.e4", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 264, 284 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d23.s0.e5", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 286, 289 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d23.s0.e6", "type": "protein", "text": [ "peroxidase" ], "offsets": [ [ 295, 305 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15984" }, { "db_name": "UniProt", "db_id": "P16147" }, { "db_name": "UniProt", "db_id": "P84714" } ] }, { "id": "DS.d23.s0.e7", "type": "protein", "text": [ "POD" ], "offsets": [ [ 307, 310 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P59097" }, { "db_name": "UniProt", "db_id": "P79076" }, { "db_name": "UniProt", "db_id": "Q5B2E9" }, { "db_name": "UniProt", "db_id": "Q5G234" }, { "db_name": "UniProt", "db_id": "Q6QWR1" }, { "db_name": "UniProt", "db_id": "Q6UG02" }, { "db_name": "UniProt", "db_id": "Q75ZP8" }, { "db_name": "UniProt", "db_id": "Q8J136" }, { "db_name": "UniProt", "db_id": "Q8J2V8" } ] }, { "id": "DS.d23.s0.e8", "type": "protein", "text": [ "LPO" ], "offsets": [ [ 328, 331 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22079" }, { "db_name": "UniProt", "db_id": "P80025" } ] } ]
[]
[]
[]
DS.d24
18068270
[ { "id": "DS.d24.s0", "text": [ "Selenium and aluminum levels were not associated to CSF Abeta42." ], "offsets": [ [ 0, 64 ] ], "type": "" }, { "id": "DS.d24.s1", "text": [ "In vitro, the degradation of synthetic Abeta substrate added to CSF was markedly accelerated by low levels (2microM) of exogenous zinc and copper." ], "offsets": [ [ 65, 211 ] ], "type": "" } ]
[ { "id": "DS.d24.s0.e0", "type": "compound", "text": [ "aluminum" ], "offsets": [ [ 13, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359268" } ] }, { "id": "DS.d24.s0.e1", "type": "protein", "text": [ "CSF" ], "offsets": [ [ 52, 55 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62757" }, { "db_name": "UniProt", "db_id": "P01587" }, { "db_name": "UniProt", "db_id": "P04141" }, { "db_name": "UniProt", "db_id": "P11052" }, { "db_name": "UniProt", "db_id": "P28773" }, { "db_name": "UniProt", "db_id": "P48749" }, { "db_name": "UniProt", "db_id": "P48750" }, { "db_name": "UniProt", "db_id": "P51748" }, { "db_name": "UniProt", "db_id": "Q0MUT8" }, { "db_name": "UniProt", "db_id": "Q29118" }, { "db_name": "UniProt", "db_id": "Q60481" } ] }, { "id": "DS.d24.s1.e0", "type": "protein", "text": [ "CSF" ], "offsets": [ [ 129, 132 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62757" }, { "db_name": "UniProt", "db_id": "P01587" }, { "db_name": "UniProt", "db_id": "P04141" }, { "db_name": "UniProt", "db_id": "P11052" }, { "db_name": "UniProt", "db_id": "P28773" }, { "db_name": "UniProt", "db_id": "P48749" }, { "db_name": "UniProt", "db_id": "P48750" }, { "db_name": "UniProt", "db_id": "P51748" }, { "db_name": "UniProt", "db_id": "Q0MUT8" }, { "db_name": "UniProt", "db_id": "Q29118" }, { "db_name": "UniProt", "db_id": "Q60481" } ] }, { "id": "DS.d24.s1.e1", "type": "compound", "text": [ "copper" ], "offsets": [ [ 204, 210 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23978" } ] } ]
[]
[]
[ { "id": "DS.d24.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d24.s1.e1", "arg2_id": "DS.d24.s1.e0", "normalized": [] } ]
DS.d25
18068871
[ { "id": "DS.d25.s0", "text": [ "Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices." ], "offsets": [ [ 0, 127 ] ], "type": "" }, { "id": "DS.d25.s1", "text": [ "Similarly, mutant PS1 impairs the ability of the cholinesterase inhibitor phenserine to enhance LTP." ], "offsets": [ [ 128, 228 ] ], "type": "" } ]
[ { "id": "DS.d25.s0.e0", "type": "protein", "text": [ "Presenilin-1" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12976" }, { "db_name": "UniProt", "db_id": "P49768" }, { "db_name": "UniProt", "db_id": "P49769" }, { "db_name": "UniProt", "db_id": "P79802" }, { "db_name": "UniProt", "db_id": "P97887" }, { "db_name": "UniProt", "db_id": "Q4JIM4" }, { "db_name": "UniProt", "db_id": "Q5R780" }, { "db_name": "UniProt", "db_id": "Q6RH31" }, { "db_name": "UniProt", "db_id": "Q8HXW5" }, { "db_name": "UniProt", "db_id": "Q9W6T7" }, { "db_name": "UniProt", "db_id": "Q9XT97" } ] }, { "id": "DS.d25.s0.e1", "type": "compound", "text": [ "NMDA" ], "offsets": [ [ 91, 95 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "22880" } ] }, { "id": "DS.d25.s1.e0", "type": "protein", "text": [ "PS1" ], "offsets": [ [ 146, 149 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49768" }, { "db_name": "UniProt", "db_id": "P79802" }, { "db_name": "UniProt", "db_id": "Q8HXW5" }, { "db_name": "UniProt", "db_id": "Q9W6T7" } ] }, { "id": "DS.d25.s1.e1", "type": "compound", "text": [ "phenserine" ], "offsets": [ [ 202, 212 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "192706" }, { "db_name": "PubChem", "db_id": "9905831" }, { "db_name": "PubChem", "db_id": "10337156" } ] } ]
[]
[]
[ { "id": "DS.d25.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d25.s0.e1", "arg2_id": "DS.d25.s0.e0", "normalized": [] }, { "id": "DS.d25.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d25.s1.e1", "arg2_id": "DS.d25.s1.e0", "normalized": [] } ]
DS.d26
18077014
[ { "id": "DS.d26.s0", "text": [ "It was found that the expression of SSAT and ODC were upregulated after reperfusion and the concentrations of spermidine and spermine were significantly decreased, while putrescine concentration was significantly increased." ], "offsets": [ [ 0, 223 ] ], "type": "" } ]
[ { "id": "DS.d26.s0.e0", "type": "protein", "text": [ "SSAT" ], "offsets": [ [ 36, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21673" }, { "db_name": "UniProt", "db_id": "P48026" }, { "db_name": "UniProt", "db_id": "P49431" }, { "db_name": "UniProt", "db_id": "Q01612" }, { "db_name": "UniProt", "db_id": "Q28999" }, { "db_name": "UniProt", "db_id": "Q3T0Q0" }, { "db_name": "UniProt", "db_id": "Q8AXL1" }, { "db_name": "UniProt", "db_id": "Q9JHW6" } ] }, { "id": "DS.d26.s0.e1", "type": "protein", "text": [ "ODC" ], "offsets": [ [ 45, 48 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O22616" }, { "db_name": "UniProt", "db_id": "P00860" }, { "db_name": "UniProt", "db_id": "P07805" }, { "db_name": "UniProt", "db_id": "P08432" }, { "db_name": "UniProt", "db_id": "P09057" }, { "db_name": "UniProt", "db_id": "P11926" }, { "db_name": "UniProt", "db_id": "P14019" }, { "db_name": "UniProt", "db_id": "P27116" }, { "db_name": "UniProt", "db_id": "P27117" }, { "db_name": "UniProt", "db_id": "P27118" }, { "db_name": "UniProt", "db_id": "P27119" }, { "db_name": "UniProt", "db_id": "P27121" }, { "db_name": "UniProt", "db_id": "P40807" }, { "db_name": "UniProt", "db_id": "P40808" }, { "db_name": "UniProt", "db_id": "P41931" }, { "db_name": "UniProt", "db_id": "P43099" }, { "db_name": "UniProt", "db_id": "P49725" }, { "db_name": "UniProt", "db_id": "P50134" }, { "db_name": "UniProt", "db_id": "P78599" }, { "db_name": "UniProt", "db_id": "Q5RFB7" }, { "db_name": "UniProt", "db_id": "Q8S3N2" }, { "db_name": "UniProt", "db_id": "Q92445" }, { "db_name": "UniProt", "db_id": "Q9BQT8" }, { "db_name": "UniProt", "db_id": "Q9UQW9" } ] }, { "id": "DS.d26.s0.e2", "type": "compound", "text": [ "spermidine" ], "offsets": [ [ 110, 120 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1102" } ] }, { "id": "DS.d26.s0.e3", "type": "compound", "text": [ "spermine" ], "offsets": [ [ 125, 133 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1103" } ] }, { "id": "DS.d26.s0.e4", "type": "compound", "text": [ "putrescine" ], "offsets": [ [ 170, 180 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1045" } ] } ]
[]
[]
[ { "id": "DS.d26.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d26.s0.e3", "arg2_id": "DS.d26.s0.e1", "normalized": [] }, { "id": "DS.d26.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d26.s0.e4", "arg2_id": "DS.d26.s0.e0", "normalized": [] }, { "id": "DS.d26.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d26.s0.e3", "arg2_id": "DS.d26.s0.e0", "normalized": [] }, { "id": "DS.d26.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d26.s0.e4", "arg2_id": "DS.d26.s0.e1", "normalized": [] }, { "id": "DS.d26.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d26.s0.e2", "arg2_id": "DS.d26.s0.e0", "normalized": [] }, { "id": "DS.d26.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d26.s0.e2", "arg2_id": "DS.d26.s0.e1", "normalized": [] } ]
DS.d27
18079026
[ { "id": "DS.d27.s0", "text": [ "In the present study, we investigated the effects of quetiapine on memory impairment and pathological changes in an amyloid precursor protein (APP)/presenilin-1 (PS-1) double transgenic mouse model of Alzheimer's disease (AD)." ], "offsets": [ [ 0, 226 ] ], "type": "" }, { "id": "DS.d27.s1", "text": [ "Quetiapine also decreased brain Abeta peptides, beta-secretase activity and expression, and the level of C99 (an APP C-terminal fragment following cleavage by beta-secretase) in the transgenic mice." ], "offsets": [ [ 227, 425 ] ], "type": "" }, { "id": "DS.d27.s2", "text": [ "Furthermore, quetiapine attenuated anxiety-like behavior, up-regulated cerebral Bcl-2 protein, and decreased cerebral nitrotyrosine in the transgenic mice." ], "offsets": [ [ 426, 581 ] ], "type": "" } ]
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[]
[]
[ { "id": "DS.d27.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d27.s1.e0", "arg2_id": "DS.d27.s1.e1", "normalized": [] }, { "id": "DS.d27.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d27.s1.e0", "arg2_id": "DS.d27.s1.e2", "normalized": [] }, { "id": "DS.d27.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d27.s2.e0", "arg2_id": "DS.d27.s2.e1", "normalized": [] } ]
DS.d28
18162361
[ { "id": "DS.d28.s0", "text": [ "Rosuvastatin rapidly phosphorylated Akt and endothelial nitric oxide synthase (eNOS) in human endothelial cells." ], "offsets": [ [ 0, 112 ] ], "type": "" }, { "id": "DS.d28.s1", "text": [ "Our findings indicate that rosuvastatin protects endothelial cells from death with phosphorylation of Akt and eNOS." ], "offsets": [ [ 113, 228 ] ], "type": "" } ]
[ { "id": "DS.d28.s0.e0", "type": "compound", "text": [ "Rosuvastatin" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "446157" } ] }, { "id": "DS.d28.s0.e1", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] }, { "id": "DS.d28.s0.e2", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 56, 77 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d28.s0.e3", "type": "protein", "text": [ "eNOS" ], "offsets": [ [ 79, 83 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29473" }, { "db_name": "UniProt", "db_id": "P29474" }, { "db_name": "UniProt", "db_id": "P70313" }, { "db_name": "UniProt", "db_id": "P79209" }, { "db_name": "UniProt", "db_id": "P97270" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q62600" } ] }, { "id": "DS.d28.s1.e0", "type": "compound", "text": [ "rosuvastatin" ], "offsets": [ [ 140, 152 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "446157" } ] }, { "id": "DS.d28.s1.e1", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 215, 218 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] }, { "id": "DS.d28.s1.e2", "type": "protein", "text": [ "eNOS" ], "offsets": [ [ 223, 227 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29473" }, { "db_name": "UniProt", "db_id": "P29474" }, { "db_name": "UniProt", "db_id": "P70313" }, { "db_name": "UniProt", "db_id": "P79209" }, { "db_name": "UniProt", "db_id": "P97270" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q62600" } ] } ]
[]
[]
[ { "id": "DS.d28.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d28.s0.e0", "arg2_id": "DS.d28.s0.e2", "normalized": [] }, { "id": "DS.d28.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d28.s0.e0", "arg2_id": "DS.d28.s0.e3", "normalized": [] }, { "id": "DS.d28.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d28.s0.e0", "arg2_id": "DS.d28.s0.e1", "normalized": [] }, { "id": "DS.d28.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d28.s1.e0", "arg2_id": "DS.d28.s1.e2", "normalized": [] }, { "id": "DS.d28.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d28.s1.e0", "arg2_id": "DS.d28.s1.e1", "normalized": [] } ]
DS.d29
18164165
[ { "id": "DS.d29.s0", "text": [ "Superoxide dismutase and glutathione peroxidase antioxidant enzyme activities and malondialdehyde levels were found to be increased; however, beta-carotene, retinol, vitamin C, vitamin E, reduced glutathione, and albumin levels were observed to be significantly decreased." ], "offsets": [ [ 0, 272 ] ], "type": "" } ]
[ { "id": "DS.d29.s0.e0", "type": "protein", "text": [ "Superoxide dismutase" ], "offsets": [ [ 0, 20 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d29.s0.e1", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 25, 47 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d29.s0.e2", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 82, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] }, { "id": "DS.d29.s0.e3", "type": "compound", "text": [ "beta-carotene" ], "offsets": [ [ 142, 155 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280489" } ] }, { "id": "DS.d29.s0.e4", "type": "compound", "text": [ "retinol" ], "offsets": [ [ 157, 164 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445354" } ] }, { "id": "DS.d29.s0.e5", "type": "compound", "text": [ "vitamin C" ], "offsets": [ [ 166, 175 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54670067" } ] }, { "id": "DS.d29.s0.e6", "type": "compound", "text": [ "vitamin E" ], "offsets": [ [ 177, 186 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" }, { "db_name": "PubChem", "db_id": "1548900" }, { "db_name": "PubChem", "db_id": "1742129" } ] }, { "id": "DS.d29.s0.e7", "type": "compound", "text": [ "reduced glutathione" ], "offsets": [ [ 188, 207 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] } ]
[]
[]
[]
DS.d30
18172601
[ { "id": "DS.d30.s0", "text": [ "Structure-function studies of nitrated SERCA2 in aging heart and skeletal muscle demonstrate stoichiometric nitration of vicinal tyrosines, Tyr (294) and Tyr (295), on the lumenal side of the membrane-spanning helix, M4, which correlates with partial inhibition of Ca(2+)-ATPase activity suggesting a possible regulatory function in down-regulating mitochondrial energy production and the associated generation of reactive oxygen/nitrogen species." ], "offsets": [ [ 0, 447 ] ], "type": "" } ]
[ { "id": "DS.d30.s0.e0", "type": "protein", "text": [ "SERCA2" ], "offsets": [ [ 39, 45 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46674" }, { "db_name": "UniProt", "db_id": "O55143" }, { "db_name": "UniProt", "db_id": "P11507" }, { "db_name": "UniProt", "db_id": "P11607" }, { "db_name": "UniProt", "db_id": "P16615" }, { "db_name": "UniProt", "db_id": "P20647" }, { "db_name": "UniProt", "db_id": "Q00779" }, { "db_name": "UniProt", "db_id": "Q03669" } ] }, { "id": "DS.d30.s0.e1", "type": "compound", "text": [ "M4" ], "offsets": [ [ 217, 219 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16682741" } ] }, { "id": "DS.d30.s0.e2", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 423, 429 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d30.s0.e3", "type": "compound", "text": [ "nitrogen" ], "offsets": [ [ 430, 438 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "947" }, { "db_name": "PubChem", "db_id": "123329" } ] } ]
[]
[]
[]
DS.d31
18177531
[ { "id": "DS.d31.s0", "text": [ "Carbon monoxide is an endogenous vasodilator gas produced by the enzyme heme oxygenase (HO)." ], "offsets": [ [ 0, 92 ] ], "type": "" } ]
[ { "id": "DS.d31.s0.e0", "type": "compound", "text": [ "Carbon monoxide" ], "offsets": [ [ 0, 15 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "281" } ] }, { "id": "DS.d31.s0.e1", "type": "protein", "text": [ "heme oxygenase" ], "offsets": [ [ 72, 86 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19998" }, { "db_name": "UniProt", "db_id": "O73688" }, { "db_name": "UniProt", "db_id": "O78497" }, { "db_name": "UniProt", "db_id": "P51271" }, { "db_name": "UniProt", "db_id": "P71119" } ] } ]
[]
[]
[ { "id": "DS.d31.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d31.s0.e0", "arg2_id": "DS.d31.s0.e1", "normalized": [] } ]
DS.d32
18179560
[ { "id": "DS.d32.s0", "text": [ "The long pentraxin 3 (PTX3) is a multifunctional soluble pattern recognition receptor, involved in several processes ranging from innate resistance and inflammation to clearance of apoptotic cells and organization of hyaluronic acid-rich extracellular matrices." ], "offsets": [ [ 0, 261 ] ], "type": "" } ]
[ { "id": "DS.d32.s0.e0", "type": "protein", "text": [ "PTX3" ], "offsets": [ [ 22, 26 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O75364" }, { "db_name": "UniProt", "db_id": "P26022" } ] }, { "id": "DS.d32.s0.e1", "type": "compound", "text": [ "hyaluronic acid" ], "offsets": [ [ 217, 232 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24759" }, { "db_name": "PubChem", "db_id": "453618" }, { "db_name": "PubChem", "db_id": "3084050" }, { "db_name": "PubChem", "db_id": "24728612" } ] } ]
[]
[]
[ { "id": "DS.d32.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d32.s0.e1", "arg2_id": "DS.d32.s0.e0", "normalized": [] } ]
DS.d33
18180755
[ { "id": "DS.d33.s0", "text": [ "The FKBP5 gene product forms part of a complex with the glucocorticoid receptor and can modulate cortisol-binding affinity." ], "offsets": [ [ 0, 123 ] ], "type": "" } ]
[ { "id": "DS.d33.s0.e0", "type": "protein", "text": [ "FKBP5" ], "offsets": [ [ 4, 9 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0C1J7" }, { "db_name": "UniProt", "db_id": "Q13451" }, { "db_name": "UniProt", "db_id": "Q5RF88" }, { "db_name": "UniProt", "db_id": "Q95L05" }, { "db_name": "UniProt", "db_id": "Q9XSH5" }, { "db_name": "UniProt", "db_id": "Q9XSI2" }, { "db_name": "UniProt", "db_id": "Q9XT11" } ] }, { "id": "DS.d33.s0.e1", "type": "protein", "text": [ "glucocorticoid receptor" ], "offsets": [ [ 56, 79 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O13186" }, { "db_name": "UniProt", "db_id": "O46567" }, { "db_name": "UniProt", "db_id": "O73673" }, { "db_name": "UniProt", "db_id": "P04150" }, { "db_name": "UniProt", "db_id": "P06536" }, { "db_name": "UniProt", "db_id": "P06537" }, { "db_name": "UniProt", "db_id": "P35547" }, { "db_name": "UniProt", "db_id": "P49115" }, { "db_name": "UniProt", "db_id": "P49843" }, { "db_name": "UniProt", "db_id": "P49844" }, { "db_name": "UniProt", "db_id": "P59667" }, { "db_name": "UniProt", "db_id": "P79269" }, { "db_name": "UniProt", "db_id": "P79686" }, { "db_name": "UniProt", "db_id": "Q5R9P5" }, { "db_name": "UniProt", "db_id": "Q6XLJ0" }, { "db_name": "UniProt", "db_id": "Q95267" }, { "db_name": "UniProt", "db_id": "Q9N1U3" } ] }, { "id": "DS.d33.s0.e2", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 97, 105 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] } ]
[]
[]
[ { "id": "DS.d33.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d33.s0.e2", "arg2_id": "DS.d33.s0.e0", "normalized": [] }, { "id": "DS.d33.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d33.s0.e2", "arg2_id": "DS.d33.s0.e1", "normalized": [] } ]
DS.d34
18190985
[ { "id": "DS.d34.s0", "text": [ "Several studies have shown that epsilon 2 carriers have lower low-density lipoprotein and apo B levels and higher high-density lipoprotein cholesterol and apo A-I levels than epsilon 3 carriers." ], "offsets": [ [ 0, 194 ] ], "type": "" } ]
[ { "id": "DS.d34.s0.e0", "type": "protein", "text": [ "epsilon" ], "offsets": [ [ 32, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05463" } ] }, { "id": "DS.d34.s0.e1", "type": "protein", "text": [ "high-density lipoprotein" ], "offsets": [ [ 114, 138 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P81182" } ] }, { "id": "DS.d34.s0.e2", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 139, 150 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d34.s0.e3", "type": "protein", "text": [ "epsilon" ], "offsets": [ [ 175, 182 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05463" } ] } ]
[]
[]
[ { "id": "DS.d34.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d34.s0.e2", "arg2_id": "DS.d34.s0.e1", "normalized": [] }, { "id": "DS.d34.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d34.s0.e2", "arg2_id": "DS.d34.s0.e0", "normalized": [] } ]
DS.d35
18191451
[ { "id": "DS.d35.s0", "text": [ "Toxicity and characterization of cholinesterase-inhibition induced by diisopropyl fluorophosphate in Artemia salina larvae." ], "offsets": [ [ 0, 123 ] ], "type": "" } ]
[ { "id": "DS.d35.s0.e0", "type": "protein", "text": [ "cholinesterase" ], "offsets": [ [ 33, 47 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P32749" }, { "db_name": "UniProt", "db_id": "P32750" }, { "db_name": "UniProt", "db_id": "P32751" }, { "db_name": "UniProt", "db_id": "P32752" }, { "db_name": "UniProt", "db_id": "P32753" }, { "db_name": "UniProt", "db_id": "P81908" } ] }, { "id": "DS.d35.s0.e1", "type": "compound", "text": [ "diisopropyl fluorophosphate" ], "offsets": [ [ 70, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5936" } ] } ]
[]
[]
[ { "id": "DS.d35.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d35.s0.e1", "arg2_id": "DS.d35.s0.e0", "normalized": [] } ]
DS.d36
18195714
[ { "id": "DS.d36.s0", "text": [ "Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice." ], "offsets": [ [ 0, 114 ] ], "type": "" }, { "id": "DS.d36.s1", "text": [ "We report that peripheral administration of lipopolysaccharide (LPS) activates IDO and culminates in a distinct depressive-like behavioral syndrome, measured by increased duration of immobility in both the forced-swim and tail suspension tests." ], "offsets": [ [ 115, 359 ] ], "type": "" }, { "id": "DS.d36.s2", "text": [ "Administration of L-kynurenine, a metabolite of tryptophan that is generated by IDO, to naive mice dose dependently induces depressive-like behavior." ], "offsets": [ [ 360, 509 ] ], "type": "" } ]
[ { "id": "DS.d36.s0.e0", "type": "compound", "text": [ "Lipopolysaccharide" ], "offsets": [ [ 0, 18 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11970143" } ] }, { "id": "DS.d36.s0.e1", "type": "protein", "text": [ "indoleamine 2,3-dioxygenase" ], "offsets": [ [ 67, 94 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14902" }, { "db_name": "UniProt", "db_id": "P28776" } ] }, { "id": "DS.d36.s1.e0", "type": "compound", "text": [ "lipopolysaccharide" ], "offsets": [ [ 159, 177 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11970143" } ] }, { "id": "DS.d36.s1.e1", "type": "protein", "text": [ "IDO" ], "offsets": [ [ 194, 197 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14902" }, { "db_name": "UniProt", "db_id": "P28776" } ] }, { "id": "DS.d36.s2.e0", "type": "compound", "text": [ "kynurenine" ], "offsets": [ [ 380, 390 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "846" } ] }, { "id": "DS.d36.s2.e1", "type": "compound", "text": [ "tryptophan" ], "offsets": [ [ 408, 418 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1148" }, { "db_name": "PubChem", "db_id": "6305" }, { "db_name": "PubChem", "db_id": "9060" }, { "db_name": "PubChem", "db_id": "5460840" } ] }, { "id": "DS.d36.s2.e2", "type": "protein", "text": [ "IDO" ], "offsets": [ [ 440, 443 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14902" }, { "db_name": "UniProt", "db_id": "P28776" } ] } ]
[]
[]
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DS.d37
18198986
[ { "id": "DS.d37.s0", "text": [ "Serum adipocyte fatty acid binding protein levels in patients with type 2 diabetes mellitus and obesity: the influence of fenofibrate treatment." ], "offsets": [ [ 0, 144 ] ], "type": "" }, { "id": "DS.d37.s1", "text": [ "Serum FABP levels were 2.5-fold higher in T2DM group relative to C and were not affected by fenofibrate treatment (C: 20.6+/-2.1 microg/l, T2DM before F: 55.6+/-5.7 microg/l, T2DM after F: 54.2+/-5.4 microg/l, p 0.0001 for C vs. T2DM before F)." ], "offsets": [ [ 145, 389 ] ], "type": "" }, { "id": "DS.d37.s2", "text": [ "FABP levels positively correlated with BMI, triglyceride levels, blood glucose, glycated hemoglobin, atherogenic index and insulin levels." ], "offsets": [ [ 390, 528 ] ], "type": "" } ]
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[]
[]
[ { "id": "DS.d37.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d37.s2.e1", "arg2_id": "DS.d37.s2.e0", "normalized": [] } ]
DS.d38
18198997
[ { "id": "DS.d38.s0", "text": [ "Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon." ], "offsets": [ [ 0, 100 ] ], "type": "" }, { "id": "DS.d38.s1", "text": [ "We demonstrated that butyrate stimulated the gene expression of both secreted (Muc2) and membrane-linked (Muc1, Muc3, Muc4) mucins." ], "offsets": [ [ 101, 232 ] ], "type": "" }, { "id": "DS.d38.s2", "text": [ "Butyrate especially induced a 6-fold increase in Muc2 gene expression in proximal colon." ], "offsets": [ [ 233, 321 ] ], "type": "" }, { "id": "DS.d38.s3", "text": [ "However, butyrate enemas did not modify the number of epithelial cells containing the protein Muc2, and caused a 2-fold decrease in the thickness of adherent mucus layer." ], "offsets": [ [ 322, 492 ] ], "type": "" } ]
[ { "id": "DS.d38.s0.e0", "type": "compound", "text": [ "Butyrate" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "264" } ] }, { "id": "DS.d38.s0.e1", "type": "protein", "text": [ "Muc" ], "offsets": [ [ 27, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0A9M0" } ] }, { "id": "DS.d38.s1.e0", "type": "compound", "text": [ "butyrate" ], "offsets": [ [ 122, 130 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "264" } ] }, { "id": "DS.d38.s1.e1", "type": "protein", "text": [ "Muc2" ], "offsets": [ [ 180, 184 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q62635" } ] }, { "id": "DS.d38.s1.e2", "type": "protein", "text": [ "Muc1" ], "offsets": [ [ 207, 211 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q02496" } ] }, { "id": "DS.d38.s2.e0", "type": "compound", "text": [ "Butyrate" ], "offsets": [ [ 233, 241 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "264" } ] }, { "id": "DS.d38.s2.e1", "type": "protein", "text": [ "Muc2" ], "offsets": [ [ 282, 286 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q62635" } ] }, { "id": "DS.d38.s3.e0", "type": "compound", "text": [ "butyrate" ], "offsets": [ [ 331, 339 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "264" } ] }, { "id": "DS.d38.s3.e1", "type": "protein", "text": [ "Muc2" ], "offsets": [ [ 416, 420 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q62635" } ] } ]
[]
[]
[ { "id": "DS.d38.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d38.s0.e0", "arg2_id": "DS.d38.s0.e1", "normalized": [] }, { "id": "DS.d38.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d38.s1.e0", "arg2_id": "DS.d38.s1.e1", "normalized": [] }, { "id": "DS.d38.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d38.s1.e0", "arg2_id": "DS.d38.s1.e2", "normalized": [] }, { "id": "DS.d38.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d38.s2.e0", "arg2_id": "DS.d38.s2.e1", "normalized": [] } ]
DS.d39
18204887
[ { "id": "DS.d39.s0", "text": [ "We examined the association of MTHFR C677T and A1298C, and changes in plasma homocysteine in 352 Tunisian patients with angiographically-demonstrated CAD, and 390 age and gender-matched healthy subjects." ], "offsets": [ [ 0, 203 ] ], "type": "" } ]
[ { "id": "DS.d39.s0.e0", "type": "protein", "text": [ "MTHFR" ], "offsets": [ [ 31, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42898" }, { "db_name": "UniProt", "db_id": "Q5I598" }, { "db_name": "UniProt", "db_id": "Q60HE5" } ] }, { "id": "DS.d39.s0.e1", "type": "compound", "text": [ "homocysteine" ], "offsets": [ [ 77, 89 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "778" } ] } ]
[]
[]
[]
DS.d40
18205042
[ { "id": "DS.d40.s0", "text": [ "However, we also observed that clotrimazol (1alpha-hydroxylase inhibitor) enhanced 25(OH)D(3)-induced CYP24 expression in breast cancer cells." ], "offsets": [ [ 0, 142 ] ], "type": "" } ]
[ { "id": "DS.d40.s0.e0", "type": "compound", "text": [ "clotrimazol" ], "offsets": [ [ 31, 42 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2812" } ] }, { "id": "DS.d40.s0.e1", "type": "protein", "text": [ "CYP24" ], "offsets": [ [ 102, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q07973" } ] } ]
[]
[]
[ { "id": "DS.d40.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d40.s0.e0", "arg2_id": "DS.d40.s0.e1", "normalized": [] } ]
DS.d41
18207583
[ { "id": "DS.d41.s0", "text": [ "Expression of senescence-associated beta-galactosidase (SA-beta-Gal) by human skin fibroblasts, effect of advanced glycation end-products and fucose or rhamnose-rich polysaccharides." ], "offsets": [ [ 0, 182 ] ], "type": "" } ]
[ { "id": "DS.d41.s0.e0", "type": "protein", "text": [ "beta-galactosidase" ], "offsets": [ [ 36, 54 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O33815" }, { "db_name": "UniProt", "db_id": "O52629" }, { "db_name": "UniProt", "db_id": "O52847" }, { "db_name": "UniProt", "db_id": "P00722" }, { "db_name": "UniProt", "db_id": "P00723" }, { "db_name": "UniProt", "db_id": "P06219" }, { "db_name": "UniProt", "db_id": "P0C1Y0" }, { "db_name": "UniProt", "db_id": "P14288" }, { "db_name": "UniProt", "db_id": "P22498" }, { "db_name": "UniProt", "db_id": "P23989" }, { "db_name": "UniProt", "db_id": "P24131" }, { "db_name": "UniProt", "db_id": "P26257" }, { "db_name": "UniProt", "db_id": "P30812" }, { "db_name": "UniProt", "db_id": "P50388" }, { "db_name": "UniProt", "db_id": "P70753" }, { "db_name": "UniProt", "db_id": "P77989" }, { "db_name": "UniProt", "db_id": "P81650" }, { "db_name": "UniProt", "db_id": "Q1G9Z4" }, { "db_name": "UniProt", "db_id": "Q47077" }, { "db_name": "UniProt", "db_id": "Q48727" }, { "db_name": "UniProt", "db_id": "Q56307" }, { "db_name": "UniProt", "db_id": "Q59140" }, { "db_name": "UniProt", "db_id": "Q59750" }, { "db_name": "UniProt", "db_id": "Q9K9C6" } ] }, { "id": "DS.d41.s0.e1", "type": "protein", "text": [ "Gal" ], "offsets": [ [ 64, 67 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10683" }, { "db_name": "UniProt", "db_id": "P11886" }, { "db_name": "UniProt", "db_id": "P47212" } ] }, { "id": "DS.d41.s0.e2", "type": "compound", "text": [ "fucose" ], "offsets": [ [ 142, 148 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "840" }, { "db_name": "PubChem", "db_id": "17106" }, { "db_name": "PubChem", "db_id": "19466" }, { "db_name": "PubChem", "db_id": "94270" }, { "db_name": "PubChem", "db_id": "439554" } ] } ]
[]
[]
[]
DS.d42
18221806
[ { "id": "DS.d42.s0", "text": [ "Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: a dose-response effect dependent on endothelial nitric oxide synthase." ], "offsets": [ [ 0, 181 ] ], "type": "" } ]
[ { "id": "DS.d42.s0.e0", "type": "compound", "text": [ "simvastatin" ], "offsets": [ [ 25, 36 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54454" }, { "db_name": "PubChem", "db_id": "4677798" } ] }, { "id": "DS.d42.s0.e1", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 159, 180 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] } ]
[]
[]
[ { "id": "DS.d42.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d42.s0.e0", "arg2_id": "DS.d42.s0.e1", "normalized": [] } ]
DS.d43
18222028
[ { "id": "DS.d43.s0", "text": [ "It has been shown that the removal efficiency of COD increased with the increasing applied current density and increasing PAC and Na (2)SO(4) dosage and the most effective removal capacity was achieved at the pH 7." ], "offsets": [ [ 0, 214 ] ], "type": "" } ]
[ { "id": "DS.d43.s0.e0", "type": "protein", "text": [ "COD" ], "offsets": [ [ 49, 52 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14678" } ] }, { "id": "DS.d43.s0.e1", "type": "compound", "text": [ "Na" ], "offsets": [ [ 130, 132 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "923" }, { "db_name": "PubChem", "db_id": "373840" } ] } ]
[]
[]
[ { "id": "DS.d43.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d43.s0.e1", "arg2_id": "DS.d43.s0.e0", "normalized": [] } ]
DS.d44
18222543
[ { "id": "DS.d44.s0", "text": [ "The protective effects of novel synthetic organoselenium compounds (Se I and Se II) against DMBA-induced changes in levels of some (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) activities and total glutathione (GSH), malonedialdehyde (MDA)) parameters in rat lung and kidney were investigated." ], "offsets": [ [ 0, 353 ] ], "type": "" } ]
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[]
[]
[]
DS.d45
18226951
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"db_id": "Q97F85" }, { "db_name": "UniProt", "db_id": "Q97RN9" }, { "db_name": "UniProt", "db_id": "Q98A80" }, { "db_name": "UniProt", "db_id": "Q98PM0" }, { "db_name": "UniProt", "db_id": "Q99Z77" }, { "db_name": "UniProt", "db_id": "Q9CCQ4" }, { "db_name": "UniProt", "db_id": "Q9CEE0" }, { "db_name": "UniProt", "db_id": "Q9I5Z0" }, { "db_name": "UniProt", "db_id": "Q9JVV6" }, { "db_name": "UniProt", "db_id": "Q9JY09" }, { "db_name": "UniProt", "db_id": "Q9K5E4" }, { "db_name": "UniProt", "db_id": "Q9K7Q9" }, { "db_name": "UniProt", "db_id": "Q9KUP3" }, { "db_name": "UniProt", "db_id": "Q9L0Y3" }, { "db_name": "UniProt", "db_id": "Q9PGB0" }, { "db_name": "UniProt", "db_id": "Q9RL99" }, { "db_name": "UniProt", "db_id": "Q9RWM6" }, { "db_name": "UniProt", "db_id": "Q9X1Y8" }, { "db_name": "UniProt", "db_id": "Q9X4Q2" }, { "db_name": "UniProt", "db_id": "Q9ZMN5" } ] }, { "id": "DS.d45.s0.e3", "type": "protein", "text": [ "COMT" ], "offsets": [ [ 162, 166 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O23760" }, { "db_name": "UniProt", "db_id": "O81646" }, { "db_name": "UniProt", "db_id": "O82054" }, { "db_name": "UniProt", "db_id": "P21964" }, { "db_name": "UniProt", "db_id": "P28002" }, { "db_name": "UniProt", "db_id": "P46484" }, { "db_name": "UniProt", "db_id": "Q06509" }, { "db_name": "UniProt", "db_id": "Q06528" }, { "db_name": "UniProt", "db_id": "Q43239" }, { "db_name": "UniProt", "db_id": "Q43609" }, { "db_name": "UniProt", "db_id": "Q6ZD89" }, { "db_name": "UniProt", "db_id": "Q8GU25" }, { "db_name": "UniProt", "db_id": "Q8LL87" }, { "db_name": "UniProt", "db_id": "Q8W013" }, { "db_name": "UniProt", "db_id": "Q99028" }, { "db_name": "UniProt", "db_id": "Q9FQY8" }, { "db_name": "UniProt", "db_id": "Q9SWC2" } ] } ]
[]
[]
[]
DS.d46
18227836
[ { "id": "DS.d46.s0", "text": [ "To test this hypothesis, we investigated whether disruption of the oxytocin gene (Oxt-/-) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP)." ], "offsets": [ [ 0, 214 ] ], "type": "" } ]
[ { "id": "DS.d46.s0.e0", "type": "protein", "text": [ "oxytocin" ], "offsets": [ [ 67, 75 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01175" }, { "db_name": "UniProt", "db_id": "P01176" }, { "db_name": "UniProt", "db_id": "P01177" }, { "db_name": "UniProt", "db_id": "P01178" }, { "db_name": "UniProt", "db_id": "P01179" }, { "db_name": "UniProt", "db_id": "P13389" }, { "db_name": "UniProt", "db_id": "P32005" }, { "db_name": "UniProt", "db_id": "P35454" }, { "db_name": "UniProt", "db_id": "P69043" }, { "db_name": "UniProt", "db_id": "P69044" }, { "db_name": "UniProt", "db_id": "P69056" }, { "db_name": "UniProt", "db_id": "P69057" }, { "db_name": "UniProt", "db_id": "P69058" } ] }, { "id": "DS.d46.s0.e1", "type": "protein", "text": [ "Oxt" ], "offsets": [ [ 82, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01179" }, { "db_name": "UniProt", "db_id": "P35454" }, { "db_name": "UniProt", "db_id": "Q5QQ53" }, { "db_name": "UniProt", "db_id": "Q7KVA1" } ] }, { "id": "DS.d46.s0.e2", "type": "compound", "text": [ "amphetamine" ], "offsets": [ [ 153, 164 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3007" }, { "db_name": "PubChem", "db_id": "5826" }, { "db_name": "PubChem", "db_id": "32893" } ] }, { "id": "DS.d46.s0.e3", "type": "compound", "text": [ "Amp" ], "offsets": [ [ 166, 169 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6083" } ] }, { "id": "DS.d46.s0.e4", "type": "compound", "text": [ "apomorphine" ], "offsets": [ [ 172, 183 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6005" } ] }, { "id": "DS.d46.s0.e5", "type": "compound", "text": [ "phencyclidine" ], "offsets": [ [ 194, 207 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6468" } ] } ]
[]
[]
[]
DS.d47
18227838
[ { "id": "DS.d47.s0", "text": [ "The mood stabilizers lithium and valproate activate the ERK pathway in prefrontal cortex and hippocampus and potentiate ERK pathway-mediated neurite growth, neuronal survival and hippocampal neurogenesis." ], "offsets": [ [ 0, 204 ] ], "type": "" } ]
[ { "id": "DS.d47.s0.e0", "type": "compound", "text": [ "lithium" ], "offsets": [ [ 21, 28 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "28486" }, { "db_name": "PubChem", "db_id": "3028194" } ] }, { "id": "DS.d47.s0.e1", "type": "compound", "text": [ "valproate" ], "offsets": [ [ 33, 42 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3121" } ] }, { "id": "DS.d47.s0.e2", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 56, 59 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] }, { "id": "DS.d47.s0.e3", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 120, 123 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] } ]
[]
[]
[ { "id": "DS.d47.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d47.s0.e0", "arg2_id": "DS.d47.s0.e2", "normalized": [] }, { "id": "DS.d47.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d47.s0.e1", "arg2_id": "DS.d47.s0.e2", "normalized": [] } ]
DS.d48
18227970
[ { "id": "DS.d48.s0", "text": [ "In the root soluble fraction, the suicide inhibitor alpha-difluoromethyl-lysine suppressed the activity of lysine decarboxylase and of ornithine decarboxylase to the same extent, but had no effect on arginine decarboxylase activity." ], "offsets": [ [ 0, 232 ] ], "type": "" } ]
[ { "id": "DS.d48.s0.e0", "type": "compound", "text": [ "difluoromethyl" ], "offsets": [ [ 58, 72 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "137670" } ] }, { "id": "DS.d48.s0.e1", "type": "compound", "text": [ "lysine" ], "offsets": [ [ 73, 79 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "866" }, { "db_name": "PubChem", "db_id": "5962" } ] }, { "id": "DS.d48.s0.e2", "type": "protein", "text": [ "lysine decarboxylase" ], "offsets": [ [ 107, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05033" } ] }, { "id": "DS.d48.s0.e3", "type": "protein", "text": [ "ornithine decarboxylase" ], "offsets": [ [ 135, 158 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O22616" }, { "db_name": "UniProt", "db_id": "P00860" }, { "db_name": "UniProt", "db_id": "P07805" }, { "db_name": "UniProt", "db_id": "P08432" }, { "db_name": "UniProt", "db_id": "P09057" }, { "db_name": "UniProt", "db_id": "P11926" }, { "db_name": "UniProt", "db_id": "P14019" }, { "db_name": "UniProt", "db_id": "P27116" }, { "db_name": "UniProt", "db_id": "P27117" }, { "db_name": "UniProt", "db_id": "P27118" }, { "db_name": "UniProt", "db_id": "P27119" }, { "db_name": "UniProt", "db_id": "P27121" }, { "db_name": "UniProt", "db_id": "P41931" }, { "db_name": "UniProt", "db_id": "P44317" }, { "db_name": "UniProt", "db_id": "P49725" }, { "db_name": "UniProt", "db_id": "P50134" }, { "db_name": "UniProt", "db_id": "P78599" }, { "db_name": "UniProt", "db_id": "Q8S3N2" }, { "db_name": "UniProt", "db_id": "Q92445" }, { "db_name": "UniProt", "db_id": "Q9UQW9" } ] }, { "id": "DS.d48.s0.e4", "type": "protein", "text": [ "arginine decarboxylase" ], "offsets": [ [ 200, 222 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O81160" }, { "db_name": "UniProt", "db_id": "O82475" }, { "db_name": "UniProt", "db_id": "P21885" }, { "db_name": "UniProt", "db_id": "P22220" }, { "db_name": "UniProt", "db_id": "P49726" }, { "db_name": "UniProt", "db_id": "Q39827" }, { "db_name": "UniProt", "db_id": "Q43075" }, { "db_name": "UniProt", "db_id": "Q819L4" }, { "db_name": "UniProt", "db_id": "Q81MS2" }, { "db_name": "UniProt", "db_id": "Q96412" }, { "db_name": "UniProt", "db_id": "Q96A70" }, { "db_name": "UniProt", "db_id": "Q9K9K5" }, { "db_name": "UniProt", "db_id": "Q9SNN0" } ] } ]
[]
[]
[ { "id": "DS.d48.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d48.s0.e0", "arg2_id": "DS.d48.s0.e3", "normalized": [] }, { "id": "DS.d48.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d48.s0.e1", "arg2_id": "DS.d48.s0.e3", "normalized": [] }, { "id": "DS.d48.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d48.s0.e0", "arg2_id": "DS.d48.s0.e2", "normalized": [] }, { "id": "DS.d48.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d48.s0.e1", "arg2_id": "DS.d48.s0.e2", "normalized": [] } ]
DS.d49
18228136
[ { "id": "DS.d49.s0", "text": [ "RT(2) Profiler PCR Array was used to identify differentially expressed genes in Dox and/or 2ME treatment groups, based on significance of results 4 genes were selected: MDR1, Bcl2, P53 and Cyclin D1." ], "offsets": [ [ 0, 199 ] ], "type": "" }, { "id": "DS.d49.s1", "text": [ "The array and western blotting showed that Bcl2 and Cyclin D1 expression were down regulated; P53 expression was not affected while MDR1 was over expressed by combination of 2ME with Dox." ], "offsets": [ [ 200, 387 ] ], "type": "" }, { "id": "DS.d49.s2", "text": [ "In conclusion, 2ME chemosensitizes resistant breast cancer cells to Dox cytotoxicity by down regulating expression of Bcl2 and Cyclin D1, augmenting caspase 3 activity as well as inducing cell cycle block in G(1) and S phases." ], "offsets": [ [ 388, 614 ] ], "type": "" } ]
[ { "id": "DS.d49.s0.e0", "type": "compound", "text": [ "2ME" ], "offsets": [ [ 91, 94 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10903" } ] }, { "id": "DS.d49.s0.e1", "type": "protein", "text": [ "MDR1" ], "offsets": [ [ 169, 173 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08183" }, { "db_name": "UniProt", "db_id": "P13568" }, { "db_name": "UniProt", "db_id": "P16875" }, { "db_name": "UniProt", "db_id": "P28873" }, { "db_name": "UniProt", "db_id": "P53258" }, { "db_name": "UniProt", "db_id": "Q06034" }, { "db_name": "UniProt", "db_id": "Q9LJX0" }, { "db_name": "UniProt", "db_id": "Q9ZR72" } ] }, { "id": "DS.d49.s0.e2", "type": "protein", "text": [ "Bcl2" ], "offsets": [ [ 175, 179 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d49.s0.e3", "type": "protein", "text": [ "P53" ], "offsets": [ [ 181, 184 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q42578" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] }, { "id": "DS.d49.s0.e4", "type": "protein", "text": [ "Cyclin" ], 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[]
[]
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DS.d50
18230627
[ { "id": "DS.d50.s0", "text": [ "Randomised trials have demonstrated that the efficacy of anti-tumour necrosis factor (TNF) agents is significantly increased by concomitant methotrexate (MTX) in rheumatoid arthritis (RA)." ], "offsets": [ [ 0, 188 ] ], "type": "" } ]
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[]
[]
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DS.d51
18243311
[ { "id": "DS.d51.s0", "text": [ "Neither apyrase nor ATP altered production of reactive oxygen intermediates (ROI) or reactive nitrogen intermediates (RNI) by bovine monocytes." ], "offsets": [ [ 0, 143 ] ], "type": "" } ]
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[]
[]
[]
DS.d52
18243368
[ { "id": "DS.d52.s0", "text": [ "In this systematic review, we have analyzed the results of 52 clinical trials, including 72 intervention groups and 6290 patients, on vitamin D supplementation in order to evaluate the experimental evidence and the effects of age and chronic immobility on responses of parathyroid hormone (PTH)." ], "offsets": [ [ 0, 295 ] ], "type": "" }, { "id": "DS.d52.s1", "text": [ "The vitamin D supplementation of the chronically immobile patients resulted in a smaller decrease in PTH 0.001)." ], "offsets": [ [ 296, 408 ] ], "type": "" }, { "id": "DS.d52.s2", "text": [ "Our results also suggest that PTH decreases quite linearly during vitamin D supplementation at any given 25-OHD level." ], "offsets": [ [ 409, 527 ] ], "type": "" } ]
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[]
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DS.d53
18248398
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[]
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DS.d54
18249383
[ { "id": "DS.d54.s0", "text": [ "To compare the changes in body composition and in leptin levels in postmenopausal women receiving hormone therapy (HT) or tibolone." ], "offsets": [ [ 0, 131 ] ], "type": "" } ]
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DS.d55
18249399
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[]
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DS.d56
18253022
[ { "id": "DS.d56.s0", "text": [ "Surprisingly, a deletion of the pilR gene affected not only insoluble Fe(III) reduction, which requires pili, but also soluble Fe(III) reduction, which, in contrast, does not require pili." ], "offsets": [ [ 0, 188 ] ], "type": "" } ]
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[]
[]
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DS.d57
18253697
[ { "id": "DS.d57.s0", "text": [ "Furthermore, the suppressive effects of P on cytochrome c release and caspase-9 and caspase-3 activation in serum-deprived MC3T3-E1 cells were also reversed by RU486." ], "offsets": [ [ 0, 166 ] ], "type": "" } ]
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"db_name": "UniProt", "db_id": "P62895" }, { "db_name": "UniProt", "db_id": "P62896" }, { "db_name": "UniProt", "db_id": "P67881" }, { "db_name": "UniProt", "db_id": "P67882" }, { "db_name": "UniProt", "db_id": "P68096" }, { "db_name": "UniProt", "db_id": "P68097" }, { "db_name": "UniProt", "db_id": "P68098" }, { "db_name": "UniProt", "db_id": "P68099" }, { "db_name": "UniProt", "db_id": "P68100" }, { "db_name": "UniProt", "db_id": "P68517" }, { "db_name": "UniProt", "db_id": "P68518" }, { "db_name": "UniProt", "db_id": "P68519" }, { "db_name": "UniProt", "db_id": "P81280" }, { "db_name": "UniProt", "db_id": "P81459" }, { "db_name": "UniProt", "db_id": "P99998" }, { "db_name": "UniProt", "db_id": "P99999" }, { "db_name": "UniProt", "db_id": "Q41346" }, { "db_name": "UniProt", "db_id": "Q4HVX7" }, { "db_name": "UniProt", "db_id": "Q52V08" }, { "db_name": "UniProt", "db_id": "Q52V09" }, { "db_name": "UniProt", "db_id": "Q52V10" }, { "db_name": "UniProt", "db_id": "Q5RFH4" }, { "db_name": "UniProt", "db_id": "Q640U4" }, { "db_name": "UniProt", "db_id": "Q6C9Q0" }, { "db_name": "UniProt", "db_id": "Q6IQM2" }, { "db_name": "UniProt", "db_id": "Q6Q4H8" }, { "db_name": "UniProt", "db_id": "Q6QLW4" }, { "db_name": "UniProt", "db_id": "Q6WUX8" }, { "db_name": "UniProt", "db_id": "Q753F4" }, { "db_name": "UniProt", "db_id": "Q7YR71" }, { "db_name": "UniProt", "db_id": "Q96VP3" } ] }, { "id": "DS.d57.s0.e1", "type": "compound", "text": [ "RU486" ], "offsets": [ [ 160, 165 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "55245" } ] } ]
[]
[]
[ { "id": "DS.d57.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d57.s0.e1", "arg2_id": "DS.d57.s0.e0", "normalized": [] } ]
DS.d58
18256928
[ { "id": "DS.d58.s0", "text": [ "Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model." ], "offsets": [ [ 0, 127 ] ], "type": "" }, { "id": "DS.d58.s1", "text": [ "However, when ERalpha negative MDA-MB-435 cells were treated with metformin, they demonstrated increased expression of vascular endothelial growth factor (VEGF) in an AMPK dependent manner; while the ERalpha positive MCF-7 cells did not." ], "offsets": [ [ 128, 365 ] ], "type": "" }, { "id": "DS.d58.s2", "text": [ "The metformin-treated group showed increased VEGF expression, intratumoral microvascular density and reduced necrosis." ], "offsets": [ [ 366, 484 ] ], "type": "" }, { "id": "DS.d58.s3", "text": [ "Metformin treatment was sufficient, however, to reduce systemic IGF-1 and the proliferation rate of tumor cells in vascularized regions." ], "offsets": [ [ 485, 621 ] ], "type": "" } ]
[ { "id": "DS.d58.s0.e0", "type": "compound", "text": [ "metformin" ], "offsets": [ [ 12, 21 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4091" } ] }, { "id": "DS.d58.s0.e1", "type": "protein", "text": [ "AMPK" ], "offsets": [ [ 22, 26 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54646" }, { "db_name": "UniProt", "db_id": "Q09136" }, { "db_name": "UniProt", "db_id": "Q9Y478" } ] }, { "id": "DS.d58.s1.e0", "type": "compound", "text": [ "metformin" ], "offsets": [ [ 194, 203 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4091" } ] }, { "id": "DS.d58.s1.e1", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 283, 287 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d58.s1.e2", "type": "protein", "text": [ "AMPK" ], "offsets": [ [ 295, 299 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54646" }, { "db_name": "UniProt", "db_id": "Q09136" }, { "db_name": "UniProt", "db_id": "Q9Y478" } ] }, { "id": "DS.d58.s2.e0", "type": "compound", "text": [ "metformin" ], "offsets": [ [ 370, 379 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4091" } ] }, { "id": "DS.d58.s2.e1", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 411, 415 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d58.s3.e0", "type": "compound", "text": [ "Metformin" ], "offsets": [ [ 485, 494 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4091" } ] }, { "id": "DS.d58.s3.e1", "type": "protein", "text": [ "IGF-1" ], "offsets": [ [ 549, 554 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q95222" } ] } ]
[]
[]
[ { "id": "DS.d58.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d58.s0.e0", "arg2_id": "DS.d58.s0.e1", "normalized": [] }, { "id": "DS.d58.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d58.s1.e0", "arg2_id": "DS.d58.s1.e2", "normalized": [] }, { "id": "DS.d58.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d58.s1.e0", "arg2_id": "DS.d58.s1.e1", "normalized": [] }, { "id": "DS.d58.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d58.s2.e0", "arg2_id": "DS.d58.s2.e1", "normalized": [] }, { "id": "DS.d58.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d58.s3.e0", "arg2_id": "DS.d58.s3.e1", "normalized": [] } ]
DS.d59
18260130
[ { "id": "DS.d59.s0", "text": [ "TNF-alpha, MCP-1, MIP-1alpha, IL-8, IL-6, IL-1beta, VEGF, IL-1ra, and IL-10 were measured from monocyte/macrophage cultures at different stages of activation and differentiation seeded onto polyethylene, polyurethane, expanded polytetrafluoroethylene, polymethyl methacrylate, and a hydrogel copolymer of 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidinone, and polyethylene glycol acrylate in tissue culture polystyrene (TCPS) plates." ], "offsets": [ [ 0, 436 ] ], "type": "" } ]
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"UniProt", "db_id": "P19874" }, { "db_name": "UniProt", "db_id": "P26894" }, { "db_name": "UniProt", "db_id": "P36925" }, { "db_name": "UniProt", "db_id": "P41324" }, { "db_name": "UniProt", "db_id": "P46653" }, { "db_name": "UniProt", "db_id": "P49113" }, { "db_name": "UniProt", "db_id": "P67813" }, { "db_name": "UniProt", "db_id": "P67814" }, { "db_name": "UniProt", "db_id": "P79255" }, { "db_name": "UniProt", "db_id": "Q102R3" }, { "db_name": "UniProt", "db_id": "Q7YRB5" }, { "db_name": "UniProt", "db_id": "Q9XSX5" } ] }, { "id": "DS.d59.s0.e4", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 36, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d59.s0.e5", "type": "protein", "text": [ "IL-1beta" ], "offsets": [ [ 42, 50 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01584" }, { "db_name": "UniProt", "db_id": "P09428" }, { "db_name": "UniProt", "db_id": "P10749" }, { "db_name": "UniProt", "db_id": "P14628" }, { "db_name": "UniProt", "db_id": "P21621" }, { "db_name": "UniProt", "db_id": "P26889" }, { "db_name": "UniProt", "db_id": "P41687" }, { "db_name": "UniProt", "db_id": "P46648" }, { "db_name": "UniProt", "db_id": "P48090" }, { "db_name": "UniProt", "db_id": "P51493" }, { "db_name": "UniProt", "db_id": "P51745" }, { "db_name": "UniProt", "db_id": "P79162" }, { "db_name": "UniProt", "db_id": "P79182" }, { "db_name": "UniProt", "db_id": "Q28292" }, { "db_name": "UniProt", "db_id": "Q28386" }, { "db_name": "UniProt", "db_id": "Q2HZH0" }, { "db_name": "UniProt", "db_id": "Q2MH07" }, { "db_name": "UniProt", "db_id": "Q63264" }, { "db_name": "UniProt", "db_id": "Q6PUD2" }, { "db_name": "UniProt", "db_id": "Q6R2X3" }, { "db_name": "UniProt", "db_id": "Q865X8" }, { "db_name": "UniProt", "db_id": "Q8WNR2" }, { "db_name": "UniProt", "db_id": "Q9WVG1" }, { "db_name": "UniProt", "db_id": "Q9XS77" } ] }, { "id": "DS.d59.s0.e6", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 52, 56 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d59.s0.e7", "type": "protein", "text": [ "IL-1ra" ], "offsets": [ [ 58, 64 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18999" }, { "db_name": "UniProt", "db_id": "O77482" }, { "db_name": "UniProt", "db_id": "P18510" }, { "db_name": "UniProt", "db_id": "P25085" }, { "db_name": "UniProt", "db_id": "P25086" }, { "db_name": "UniProt", "db_id": "P26890" }, { "db_name": "UniProt", "db_id": "Q29056" }, { "db_name": "UniProt", "db_id": "Q866R8" }, { "db_name": "UniProt", "db_id": "Q9BEH0" }, { "db_name": "UniProt", "db_id": "Q9GMZ4" } ] }, { "id": "DS.d59.s0.e8", "type": "protein", "text": [ "IL-10" ], "offsets": [ [ 70, 75 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46673" }, { "db_name": "UniProt", "db_id": "O97798" }, { "db_name": "UniProt", "db_id": "P18893" }, { "db_name": "UniProt", "db_id": "P22301" }, { "db_name": "UniProt", "db_id": "P29456" }, { "db_name": "UniProt", "db_id": "P43480" }, { "db_name": "UniProt", "db_id": "P46651" }, { "db_name": "UniProt", "db_id": "P47965" }, { "db_name": "UniProt", "db_id": "P48411" }, { "db_name": "UniProt", "db_id": "P51496" }, { "db_name": "UniProt", "db_id": "P51497" }, { "db_name": "UniProt", "db_id": "P51746" }, { "db_name": "UniProt", "db_id": "P55029" }, { "db_name": "UniProt", "db_id": "P79338" }, { "db_name": "UniProt", "db_id": "Q0Z972" }, { "db_name": "UniProt", "db_id": "Q25BC1" }, { "db_name": "UniProt", "db_id": "Q28374" }, { "db_name": "UniProt", "db_id": "Q29055" }, { "db_name": "UniProt", "db_id": "Q29408" }, { "db_name": "UniProt", "db_id": "Q2PE73" }, { "db_name": "UniProt", "db_id": "Q5Q0V6" }, { "db_name": "UniProt", "db_id": "Q865X4" }, { "db_name": "UniProt", "db_id": "Q8MKG9" }, { "db_name": "UniProt", "db_id": "Q9JHK7" }, { "db_name": "UniProt", "db_id": "Q9TSJ4" }, { "db_name": "UniProt", "db_id": "Q9Z1Y5" } ] }, { "id": "DS.d59.s0.e9", "type": "compound", "text": [ "polyurethane" ], "offsets": [ [ 204, 216 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "12254" } ] }, { "id": "DS.d59.s0.e10", "type": "compound", "text": [ "polymethyl methacrylate" ], "offsets": [ [ 252, 275 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6658" } ] }, { "id": "DS.d59.s0.e11", "type": "compound", "text": [ "2-hydroxyethyl methacrylate" ], "offsets": [ [ 305, 332 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "13360" } ] }, { "id": "DS.d59.s0.e12", "type": "compound", "text": [ "1-vinyl-2-pyrrolidinone" ], "offsets": [ [ 334, 357 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6917" } ] }, { "id": "DS.d59.s0.e13", "type": "compound", "text": [ "polystyrene" ], "offsets": [ [ 410, 421 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7501" } ] } ]
[]
[]
[]
DS.d60
18262559
[ { "id": "DS.d60.s0", "text": [ "Systemic administration of hemoglobin vesicle elevates tumor tissue oxygen tension and modifies tumor response to irradiation." ], "offsets": [ [ 0, 126 ] ], "type": "" } ]
[ { "id": "DS.d60.s0.e0", "type": "protein", "text": [ "hemoglobin" ], "offsets": [ [ 27, 37 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15160" }, { "db_name": "UniProt", "db_id": "P17724" }, { "db_name": "UniProt", "db_id": "P73925" }, { "db_name": "UniProt", "db_id": "Q03459" } ] }, { "id": "DS.d60.s0.e1", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 68, 74 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] } ]
[]
[]
[ { "id": "DS.d60.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d60.s0.e1", "arg2_id": "DS.d60.s0.e0", "normalized": [] } ]
DS.d61
18262738
[ { "id": "DS.d61.s0", "text": [ "The participation of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK) in capacitation induced by ONOO (-) was evaluated by incubation with specific inhibitors (50 microM H-89, 0.1 microM bisindolylmaleimide I, and 3 microM genistein, respectively)." ], "offsets": [ [ 0, 280 ] ], "type": "" } ]
[ { "id": "DS.d61.s0.e0", "type": "protein", "text": [ "protein kinase A" ], "offsets": [ [ 21, 37 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q05608" }, { "db_name": "UniProt", "db_id": "Q9RI12" } ] }, { "id": "DS.d61.s0.e1", "type": "protein", "text": [ "protein kinase C" ], "offsets": [ [ 45, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "Q25378" } ] }, { "id": "DS.d61.s0.e2", "type": "protein", "text": [ "PKC" ], "offsets": [ [ 63, 66 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05130" }, { "db_name": "UniProt", "db_id": "P13677" }, { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "P34722" } ] }, { "id": "DS.d61.s0.e3", "type": "compound", "text": [ "ONOO" ], "offsets": [ [ 129, 133 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5460609" } ] }, { "id": "DS.d61.s0.e4", "type": "compound", "text": [ "bisindolylmaleimide I" ], "offsets": [ [ 219, 240 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2396" } ] }, { "id": "DS.d61.s0.e5", "type": "compound", "text": [ "genistein" ], "offsets": [ [ 255, 264 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280961" } ] } ]
[]
[]
[]
DS.d62
18266054
[ { "id": "DS.d62.s0", "text": [ "At the time, glutathione reductase activity was significantly inhibited and gamma-glutamyl cysteine increased by ACA exposure." ], "offsets": [ [ 0, 126 ] ], "type": "" } ]
[ { "id": "DS.d62.s0.e0", "type": "protein", "text": [ "glutathione reductase" ], "offsets": [ [ 13, 34 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15770" }, { "db_name": "UniProt", "db_id": "P06715" }, { "db_name": "UniProt", "db_id": "P11804" }, { "db_name": "UniProt", "db_id": "P23189" }, { "db_name": "UniProt", "db_id": "P41921" }, { "db_name": "UniProt", "db_id": "P43783" }, { "db_name": "UniProt", "db_id": "P48638" }, { "db_name": "UniProt", "db_id": "P48639" }, { "db_name": "UniProt", "db_id": "P70619" }, { "db_name": "UniProt", "db_id": "P78965" }, { "db_name": "UniProt", "db_id": "Q60151" }, { "db_name": "UniProt", "db_id": "Q6BPI1" }, { "db_name": "UniProt", "db_id": "Q6C5H4" }, { "db_name": "UniProt", "db_id": "Q6FRV2" }, { "db_name": "UniProt", "db_id": "Q6HA23" }, { "db_name": "UniProt", "db_id": "Q74ZK4" }, { "db_name": "UniProt", "db_id": "Q873E8" }, { "db_name": "UniProt", "db_id": "Q94655" } ] }, { "id": "DS.d62.s0.e1", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 91, 99 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] } ]
[]
[]
[]
DS.d63
18268501
[ { "id": "DS.d63.s0", "text": [ "The effect of the polymorphism is non-conservative and results in a glutamine to arginine change (Gln460Arg), which is likely to affect P2RX7 dimerization and protein-protein interactions." ], "offsets": [ [ 0, 188 ] ], "type": "" } ]
[ { "id": "DS.d63.s0.e0", "type": "compound", "text": [ "glutamine" ], "offsets": [ [ 68, 77 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] }, { "id": "DS.d63.s0.e1", "type": "compound", "text": [ "arginine" ], "offsets": [ [ 81, 89 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "232" }, { "db_name": "PubChem", "db_id": "4367" }, { "db_name": "PubChem", "db_id": "6322" } ] }, { "id": "DS.d63.s0.e2", "type": "protein", "text": [ "P2RX7" ], "offsets": [ [ 136, 141 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q99572" } ] } ]
[]
[]
[ { "id": "DS.d63.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d63.s0.e1", "arg2_id": "DS.d63.s0.e2", "normalized": [] }, { "id": "DS.d63.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d63.s0.e0", "arg2_id": "DS.d63.s0.e2", "normalized": [] } ]
DS.d64
18270841
[ { "id": "DS.d64.s0", "text": [ "Increased somatostatin tone and decreased ghrelin concentrations may also contribute to reduced GH levels." ], "offsets": [ [ 0, 106 ] ], "type": "" } ]
[ { "id": "DS.d64.s0.e0", "type": "compound", "text": [ "somatostatin" ], "offsets": [ [ 10, 22 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16129681" }, { "db_name": "PubChem", "db_id": "16129706" } ] }, { "id": "DS.d64.s0.e1", "type": "protein", "text": [ "ghrelin" ], "offsets": [ [ 42, 49 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6BEG6" }, { "db_name": "UniProt", "db_id": "Q6BEG7" }, { "db_name": "UniProt", "db_id": "Q9BDJ6" }, { "db_name": "UniProt", "db_id": "Q9BEF8" }, { "db_name": "UniProt", "db_id": "Q9EQX0" }, { "db_name": "UniProt", "db_id": "Q9GKY5" }, { "db_name": "UniProt", "db_id": "Q9QYH7" }, { "db_name": "UniProt", "db_id": "Q9UBU3" } ] } ]
[]
[]
[]
DS.d65
18272254
[ { "id": "DS.d65.s0", "text": [ "Inhibition of LTP by beta-amyloid is prevented by activation of beta2 adrenoceptors and stimulation of the cAMP/PKA signalling pathway." ], "offsets": [ [ 0, 135 ] ], "type": "" } ]
[ { "id": "DS.d65.s0.e0", "type": "protein", "text": [ "beta2 adrenoceptors" ], "offsets": [ [ 64, 83 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O70431" }, { "db_name": "UniProt", "db_id": "P04274" }, { "db_name": "UniProt", "db_id": "P07550" }, { "db_name": "UniProt", "db_id": "P10608" }, { "db_name": "UniProt", "db_id": "P18762" }, { "db_name": "UniProt", "db_id": "P54833" }, { "db_name": "UniProt", "db_id": "Q28044" }, { "db_name": "UniProt", "db_id": "Q28509" }, { "db_name": "UniProt", "db_id": "Q28997" }, { "db_name": "UniProt", "db_id": "Q4KWL2" }, { "db_name": "UniProt", "db_id": "Q8UUY8" }, { "db_name": "UniProt", "db_id": "Q9TST5" } ] }, { "id": "DS.d65.s0.e1", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 107, 111 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] } ]
[]
[]
[]
DS.d66
18274872
[ { "id": "DS.d66.s0", "text": [ ") O2 (-) and H2O2 in H. plumaeforme was respectively related to the low activity of SOD and the decreased activity of CAT." ], "offsets": [ [ 0, 122 ] ], "type": "" } ]
[ { "id": "DS.d66.s0.e0", "type": "compound", "text": [ "O2" ], "offsets": [ [ 2, 4 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" }, { "db_name": "PubChem", "db_id": "5359597" } ] }, { "id": "DS.d66.s0.e1", "type": "compound", "text": [ "H2O2" ], "offsets": [ [ 13, 17 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "784" } ] }, { "id": "DS.d66.s0.e2", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 84, 87 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d66.s0.e3", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 118, 121 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P00485" }, { "db_name": "UniProt", "db_id": "P00486" }, { "db_name": "UniProt", "db_id": "P00487" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P06135" }, { "db_name": "UniProt", "db_id": "P07641" }, { "db_name": "UniProt", "db_id": "P11504" }, { "db_name": "UniProt", "db_id": "P20074" }, { "db_name": "UniProt", "db_id": "P22782" }, { "db_name": "UniProt", "db_id": "P25309" }, { "db_name": "UniProt", "db_id": "P25819" }, { "db_name": "UniProt", "db_id": "P26825" }, { "db_name": "UniProt", "db_id": "P26826" }, { "db_name": "UniProt", "db_id": "P32796" }, { "db_name": "UniProt", "db_id": "P36882" }, { "db_name": "UniProt", "db_id": "P36883" }, { "db_name": "UniProt", "db_id": "P43155" }, { "db_name": "UniProt", "db_id": "P47934" }, { "db_name": "UniProt", "db_id": "P49417" }, { "db_name": "UniProt", "db_id": "P52826" }, { "db_name": "UniProt", "db_id": "P58777" }, { "db_name": "UniProt", "db_id": "P62577" }, { "db_name": "UniProt", "db_id": "P62578" }, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] } ]
[]
[]
[ { "id": "DS.d66.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d66.s0.e0", "arg2_id": "DS.d66.s0.e2", "normalized": [] }, { "id": "DS.d66.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d66.s0.e1", "arg2_id": "DS.d66.s0.e3", "normalized": [] }, { "id": "DS.d66.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d66.s0.e1", "arg2_id": "DS.d66.s0.e2", "normalized": [] }, { "id": "DS.d66.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d66.s0.e0", "arg2_id": "DS.d66.s0.e3", "normalized": [] } ]

Dataset Card for CPI

The compound-protein relationship (CPI) dataset consists of 2,613 sentences from abstracts containing annotations of proteins, small molecules, and their relationships.

Citation Information

@article{doring2020automated,
  title={Automated recognition of functional compound-protein relationships in literature},
  author={D{\"o}ring, Kersten and Qaseem, Ammar and Becer, Michael and Li, Jianyu and Mishra, Pankaj and Gao, Mingjie and Kirchner, Pascal and Sauter, Florian and Telukunta, Kiran K and Moumbock, Aur{\'e}lien FA and others},
  journal={Plos one},
  volume={15},
  number={3},
  pages={e0220925},
  year={2020},
  publisher={Public Library of Science San Francisco, CA USA}
}
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