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DS.d1888
18945757
[ { "id": "DS.d1888.s0", "type": "", "text": [ "This review will focus on recent evidence that nitric oxide, natriuretic peptides and neuropeptide Y act by converging on neuronal cyclic nucleotide-dependent pathways to alter the autonomic phenotype in both health and disease." ], "offsets": [ [ 0, 228 ] ] } ]
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[]
[]
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DS.d1889
18945783
[ { "id": "DS.d1889.s0", "type": "", "text": [ "Deletion of the first cysteine-rich region of the varicella-zoster virus glycoprotein E ectodomain abolishes the gE and gI interaction and differentially affects cell-cell spread and viral entry." ], "offsets": [ [ 0, 195 ] ] } ]
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[]
[]
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DS.d1890
18945810
[ { "id": "DS.d1890.s0", "type": "", "text": [ "Glucocorticoid-activated GR repressed COX-2 gene induction by lipopolysaccharide (LPS)." ], "offsets": [ [ 0, 87 ] ] } ]
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[]
[]
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DS.d1891
18945821
[ { "id": "DS.d1891.s0", "type": "", "text": [ "Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers." ], "offsets": [ [ 0, 100 ] ] } ]
[ { "id": "DS.d1891.s0.e0", "type": "protein", "text": [ "glycoprotein" ], "offsets": [ [ 16, 28 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] }, { "id": "DS.d1891.s0.e1", "type": "compound", "text": [ "paclitaxel" ], "offsets": [ [ 38, 48 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4666" }, { "db_name": "PubChem", "db_id": "5352019" }, { "db_name": "PubChem", "db_id": "6713921" }, { "db_name": "PubChem", "db_id": "6915727" }, { "db_name": "PubChem", "db_id": "44155032" }, { "db_name": "PubChem", "db_id": "53313247" } ] } ]
[]
[]
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DS.d1892
18945824
[ { "id": "DS.d1892.s0", "type": "", "text": [ "The data provide the first demonstration for the presence of V2R in primary cilia of renal epithelial cells, and a functional cAMP-signaling pathway, which targets ciliary channel function and may help control the sensory function of the primary cilium." ], "offsets": [ [ 0, 253 ] ] } ]
[ { "id": "DS.d1892.s0.e0", "type": "protein", "text": [ "V2R" ], "offsets": [ [ 61, 64 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77808" }, { "db_name": "UniProt", "db_id": "P30518" } ] }, { "id": "DS.d1892.s0.e1", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 126, 130 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] } ]
[]
[]
[]
DS.d1893
18945826
[ { "id": "DS.d1893.s0", "type": "", "text": [ "The endothelial (Ca(2+))(CYT) response to bradykinin (100 nM) was significantly attenuated." ], "offsets": [ [ 0, 91 ] ] } ]
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[]
[]
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DS.d1894
18945930
[ { "id": "DS.d1894.s0", "type": "", "text": [ "The purpose of this research was to enhance intranasal drug targeting to the CNS by incorporating a vasoconstrictor (phenylephrine (PHE)) into nasal formulations containing therapeutic neuropeptides (hypocretin-1 (HC) or the dipeptide L-Tyr-D-Arg (D-KTP))." ], "offsets": [ [ 0, 256 ] ] } ]
[ { "id": "DS.d1894.s0.e0", "type": "protein", "text": [ "neuropeptides" ], "offsets": [ [ 185, 198 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21259" } ] }, { "id": "DS.d1894.s0.e1", "type": "protein", "text": [ "hypocretin-1" ], "offsets": [ [ 200, 212 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O43612" }, { "db_name": "UniProt", "db_id": "O55232" }, { "db_name": "UniProt", "db_id": "O55241" }, { "db_name": "UniProt", "db_id": "O77668" }, { "db_name": "UniProt", "db_id": "P56717" }, { "db_name": "UniProt", "db_id": "Q9GLF6" } ] }, { "id": "DS.d1894.s0.e2", "type": "compound", "text": [ "KTP" ], "offsets": [ [ 250, 253 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "446833" } ] } ]
[]
[]
[]
DS.d1895
18945988
[ { "id": "DS.d1895.s0", "type": "", "text": [ "CpG dinucleotides identified in Bhlhb2, Pparg, E2f, and Egr1 binding sites at the Prkce gene promoter were densely methylated in males and females and were unaffected by cocaine exposure." ], "offsets": [ [ 0, 187 ] ] } ]
[ { "id": "DS.d1895.s0.e0", "type": "compound", "text": [ "CpG" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6804" } ] }, { "id": "DS.d1895.s0.e1", "type": "protein", "text": [ "Bhlhb2" ], "offsets": [ [ 32, 38 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35185" }, { "db_name": "UniProt", "db_id": "O35780" } ] }, { "id": "DS.d1895.s0.e2", "type": "protein", "text": [ "Pparg" ], "offsets": [ [ 40, 45 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O88275" }, { "db_name": "UniProt", "db_id": "P37234" }, { "db_name": "UniProt", "db_id": "P37238" } ] }, { "id": "DS.d1895.s0.e3", "type": "protein", "text": [ "E2f" ], "offsets": [ [ 47, 50 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q27368" } ] }, { "id": "DS.d1895.s0.e4", "type": "protein", "text": [ "Egr1" ], "offsets": [ [ 56, 60 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08046" }, { "db_name": "UniProt", "db_id": "P08154" }, { "db_name": "UniProt", "db_id": "P26632" } ] }, { "id": "DS.d1895.s0.e5", "type": "protein", "text": [ "Prkce" ], "offsets": [ [ 82, 87 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09216" }, { "db_name": "UniProt", "db_id": "P16054" } ] } ]
[]
[]
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