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1.0alpha7.train.0
24813911
[ { "id": "1.0alpha7.train.0.sent", "type": "sentence", "text": [ "Moreover, the in vitro binding of NF-κB or Sp1 to its target DNA was not affected by the presence of K-12." ], "offsets": [ [ 0, 106 ] ] } ]
[ { "id": "1.0alpha7.train.0.ent0_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 61, 64 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.0.ent1_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 43, 46 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.0.ent2_0", "type": "protein", "text": [ "NF-κB" ], "offsets": [ [ 34, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4790" }, { "db_name": "hgnc", "db_id": "NFKB1" }, { "db_name": "uniprot", "db_id": "P19838" } ] }, { "id": "1.0alpha7.train.0.ent3_0", "type": "chemical", "text": [ "K-12" ], "offsets": [ [ 101, 105 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "469668" } ] } ]
[]
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1.0alpha7.train.1
22578317
[ { "id": "1.0alpha7.train.1.sent", "type": "sentence", "text": [ "No appreciable binding of Ly49C to Db could be detected in the cell-cell adhesion assay by antibody blocking or by employing cells from Kb / mice that express Db normally ( Figure 3 and Figure 4)." ], "offsets": [ [ 0, 205 ] ] } ]
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[]
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[ { "id": "1.0alpha7.train.1.rel0s1.0alpha7.train.1.ent0_0.o1.0alpha7.train.1.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1.ent0_0", "arg2_id": "1.0alpha7.train.1.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.1.rel0s1.0alpha7.train.1.ent1_1.o1.0alpha7.train.1.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1.ent1_1", "arg2_id": "1.0alpha7.train.1.ent2_0", "normalized": [] } ]
1.0alpha7.train.2
9378102
[ { "id": "1.0alpha7.train.2.sent", "type": "sentence", "text": [ "The yeast two-hybrid interaction assays indicated that filamin-A does not bind to any integrin β subunit, whereas filamin-B only interacts with β1A." ], "offsets": [ [ 0, 148 ] ] } ]
[ { "id": "1.0alpha7.train.2.ent0_0", "type": "protein", "text": [ "filamin-A" ], "offsets": [ [ 55, 64 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2316" }, { "db_name": "hgnc", "db_id": "FLNA" }, { "db_name": "uniprot", "db_id": "P21333" } ] }, { "id": "1.0alpha7.train.2.ent1_0", "type": "protein", "text": [ "filamin-B" ], "offsets": [ [ 114, 123 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2317" }, { "db_name": "hgnc", "db_id": "FLNB" }, { "db_name": "uniprot", "db_id": "O75369" } ] }, { "id": "1.0alpha7.train.2.ent2_0", "type": "protein", "text": [ "integrin β" ], "offsets": [ [ 86, 96 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2247" }, { "db_name": "hgnc", "db_id": "FGF2" }, { "db_name": "uniprot", "db_id": "P09038" } ] }, { "id": "1.0alpha7.train.2.ent3_0", "type": "protein-isoform", "text": [ "β1A" ], "offsets": [ [ 144, 147 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.3
16358135
[ { "id": "1.0alpha7.train.3.sent", "type": "sentence", "text": [ " Because FLICE2 does not directly bind DR4 or DR5, a yet to be identified adaptor molecule is presumably responsible for this linkage. " ], "offsets": [ [ 0, 139 ] ] } ]
[ { "id": "1.0alpha7.train.3.ent0_0", "type": "protein", "text": [ "DR5" ], "offsets": [ [ 49, 52 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8795" }, { "db_name": "hgnc", "db_id": "TNFRSF10B" }, { "db_name": "uniprot", "db_id": "O14763" } ] }, { "id": "1.0alpha7.train.3.ent1_0", "type": "protein", "text": [ "FLICE2" ], "offsets": [ [ 10, 16 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "843" }, { "db_name": "hgnc", "db_id": "CASP10" }, { "db_name": "uniprot", "db_id": "Q92851" } ] }, { "id": "1.0alpha7.train.3.ent2_0", "type": "protein", "text": [ "DR4" ], "offsets": [ [ 41, 44 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8797" }, { "db_name": "hgnc", "db_id": "TNFRSF10A" }, { "db_name": "uniprot", "db_id": "O00220" } ] } ]
[]
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[ { "id": "1.0alpha7.train.3.rel0s1.0alpha7.train.3.ent1_0.o1.0alpha7.train.3.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.3.ent1_0", "arg2_id": "1.0alpha7.train.3.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.3.rel1s1.0alpha7.train.3.ent0_0.o1.0alpha7.train.3.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.3.ent0_0", "arg2_id": "1.0alpha7.train.3.ent1_0", "normalized": [] } ]
1.0alpha7.train.4
2062980
[ { "id": "1.0alpha7.train.4.sent", "type": "sentence", "text": [ "We have thus examined whether actin binding of fascin can be regulated in a calcium-dependent way by controlling actin binding of caldesmon with Ca2+/calmodulin." ], "offsets": [ [ 0, 161 ] ] } ]
[ { "id": "1.0alpha7.train.4.ent0_0", "type": "protein", "text": [ "calmodulin" ], "offsets": [ [ 150, 160 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "801" }, { "db_name": "hgnc", "db_id": "CALM1" }, { "db_name": "uniprot", "db_id": "P0DP23" } ] }, { "id": "1.0alpha7.train.4.ent1_0", "type": "protein", "text": [ "Ca2+/calmodulin" ], "offsets": [ [ 145, 160 ] ], "normalized": [] }, { "id": "1.0alpha7.train.4.ent2_0", "type": "chemical", "text": [ "Ca2+" ], "offsets": [ [ 145, 149 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.4.ent3_0", "type": "chemical", "text": [ "calcium" ], "offsets": [ [ 76, 83 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.4.ent4_0", "type": "protein", "text": [ "fascin" ], "offsets": [ [ 47, 53 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6624" }, { "db_name": "hgnc", "db_id": "FSCN1" }, { "db_name": "uniprot", "db_id": "C9JPH9" } ] }, { "id": "1.0alpha7.train.4.ent5_0", "type": "protein", "text": [ "caldesmon" ], "offsets": [ [ 130, 139 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "800" }, { "db_name": "hgnc", "db_id": "CALD1" }, { "db_name": "uniprot", "db_id": "E9PGZ1" } ] }, { "id": "1.0alpha7.train.4.ent6_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 30, 35 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.4.ent7_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 113, 118 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] } ]
[]
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1.0alpha7.train.5
609763
[ { "id": "1.0alpha7.train.5.sent", "type": "sentence", "text": [ "Therefore, we cannot rule out that some variations in the binding of three apoE isotypes to Abeta peptides will be found when other apoE preparations are used." ], "offsets": [ [ 0, 159 ] ] } ]
[ { "id": "1.0alpha7.train.5.ent0_0", "type": "protein", "text": [ "apoE" ], "offsets": [ [ 75, 79 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "348" }, { "db_name": "hgnc", "db_id": "APOE" }, { "db_name": "uniprot", "db_id": "P02649" } ] }, { "id": "1.0alpha7.train.5.ent1_1", "type": "protein", "text": [ "apoE" ], "offsets": [ [ 132, 136 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "348" }, { "db_name": "hgnc", "db_id": "APOE" }, { "db_name": "uniprot", "db_id": "P02649" } ] }, { "id": "1.0alpha7.train.5.ent2_0", "type": "peptide", "text": [ "Abeta" ], "offsets": [ [ 92, 97 ] ], "normalized": [] } ]
[]
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[ { "id": "1.0alpha7.train.5.rel0s1.0alpha7.train.5.ent0_0.o1.0alpha7.train.5.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.5.ent0_0", "arg2_id": "1.0alpha7.train.5.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.5.rel0s1.0alpha7.train.5.ent1_1.o1.0alpha7.train.5.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.5.ent1_1", "arg2_id": "1.0alpha7.train.5.ent2_0", "normalized": [] } ]
1.0alpha7.train.6
2062658
[ { "id": "1.0alpha7.train.6.sent", "type": "sentence", "text": [ "When calmodulin is added, the inhibition of fascin-actin interaction by caldesmon and TM becomes Ca2+ dependent because Ca2+/calmodulin blocks actin binding of caldesmon." ], "offsets": [ [ 0, 177 ] ] } ]
[ { "id": "1.0alpha7.train.6.ent0_0", "type": "protein", "text": [ "calmodulin" ], "offsets": [ [ 6, 16 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "801" }, { "db_name": "hgnc", "db_id": "CALM1" }, { "db_name": "uniprot", "db_id": "P0DP23" } ] }, { "id": "1.0alpha7.train.6.ent1_1", "type": "protein", "text": [ "calmodulin" ], "offsets": [ [ 130, 140 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "801" }, { "db_name": "hgnc", "db_id": "CALM1" }, { "db_name": "uniprot", "db_id": "P0DP23" } ] }, { "id": "1.0alpha7.train.6.ent2_0", "type": "chemical", "text": [ "Ca2+" ], "offsets": [ [ 101, 105 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.6.ent3_1", "type": "chemical", "text": [ "Ca2+" ], "offsets": [ [ 125, 129 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.6.ent4_0", "type": "protein", "text": [ "Ca2+/calmodulin" ], "offsets": [ [ 125, 140 ] ], "normalized": [] }, { "id": "1.0alpha7.train.6.ent5_0", "type": "protein", "text": [ "fascin" ], "offsets": [ [ 46, 52 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6624" }, { "db_name": "hgnc", "db_id": "FSCN1" }, { "db_name": "uniprot", "db_id": "C9JPH9" } ] }, { "id": "1.0alpha7.train.6.ent6_0", "type": "protein", "text": [ "caldesmon" ], "offsets": [ [ 75, 84 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "800" }, { "db_name": "hgnc", "db_id": "CALD1" }, { "db_name": "uniprot", "db_id": "E9PGZ1" } ] }, { "id": "1.0alpha7.train.6.ent7_1", "type": "protein", "text": [ "caldesmon" ], "offsets": [ [ 167, 176 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "800" }, { "db_name": "hgnc", "db_id": "CALD1" }, { "db_name": "uniprot", "db_id": "E9PGZ1" } ] }, { "id": "1.0alpha7.train.6.ent8_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 53, 58 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.6.ent9_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 149, 154 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] } ]
[]
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[ { "id": "1.0alpha7.train.6.rel0s1.0alpha7.train.6.ent5_0.o1.0alpha7.train.6.ent8_0", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent5_0", "arg2_id": "1.0alpha7.train.6.ent8_0", "normalized": [] }, { "id": "1.0alpha7.train.6.rel0s1.0alpha7.train.6.ent5_0.o1.0alpha7.train.6.ent9_1", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent5_0", "arg2_id": "1.0alpha7.train.6.ent9_1", "normalized": [] }, { "id": "1.0alpha7.train.6.rel1s1.0alpha7.train.6.ent6_0.o1.0alpha7.train.6.ent8_0", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent6_0", "arg2_id": "1.0alpha7.train.6.ent8_0", "normalized": [] }, { "id": "1.0alpha7.train.6.rel1s1.0alpha7.train.6.ent6_0.o1.0alpha7.train.6.ent9_1", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent6_0", "arg2_id": "1.0alpha7.train.6.ent9_1", "normalized": [] }, { "id": "1.0alpha7.train.6.rel1s1.0alpha7.train.6.ent7_1.o1.0alpha7.train.6.ent8_0", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent7_1", "arg2_id": "1.0alpha7.train.6.ent8_0", "normalized": [] }, { "id": "1.0alpha7.train.6.rel1s1.0alpha7.train.6.ent7_1.o1.0alpha7.train.6.ent9_1", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent7_1", "arg2_id": "1.0alpha7.train.6.ent9_1", "normalized": [] } ]
1.0alpha7.train.7
7056113
[ { "id": "1.0alpha7.train.7.sent", "type": "sentence", "text": [ "Briefly, the oligonucleotide library was incubated with fusion proteins bound to either GST-coated bead-bound fusion proteins (GST-tag) or nickel/nitrilotriacetic acid matrix-bound fusion proteins (histidine-tag) in a buffer containing 20 mM Tris (pH 8.0), 50 mM KCl, 1 mM DTT, 0.5 mM EDTA, 10% glycerol, 20 μg/ml BSA, and 2 μg/ml poly(dI)⋅poly(dc)." ], "offsets": [ [ 0, 349 ] ] } ]
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[]
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[]
1.0alpha7.train.8
15405236
[ { "id": "1.0alpha7.train.8.sent", "type": "sentence", "text": [ "Extracts were incubated with 20 mug of Gst-RalGDS-RBD precoupled to gluthathione beads to isolate GTP-bound (activated) Rap1." ], "offsets": [ [ 0, 128 ] ] } ]
[ { "id": "1.0alpha7.train.8.ent0_0", "type": "protein", "text": [ "RalGDS" ], "offsets": [ [ 44, 50 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5900" }, { "db_name": "hgnc", "db_id": "RALGDS" }, { "db_name": "uniprot", "db_id": "Q12967" } ] }, { "id": "1.0alpha7.train.8.ent1_0", "type": "chemical", "text": [ "gluthathione" ], "offsets": [ [ 69, 81 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "124886" } ] }, { "id": "1.0alpha7.train.8.ent2_0", "type": "protein", "text": [ "Rap1" ], "offsets": [ [ 123, 127 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5906" }, { "db_name": "hgnc", "db_id": "RAP1A" }, { "db_name": "uniprot", "db_id": "P62834" } ] }, { "id": "1.0alpha7.train.8.ent3_0", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 100, 103 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.8.ent4_0", "type": "protein", "text": [ "(activated) Rap1" ], "offsets": [ [ 110, 127 ] ], "normalized": [] }, { "id": "1.0alpha7.train.8.ent5_0", "type": "fusion-protein", "text": [ "Gst-RalGDS-RBD" ], "offsets": [ [ 40, 54 ] ], "normalized": [] }, { "id": "1.0alpha7.train.8.ent6_0", "type": "protein-domain", "text": [ "RBD" ], "offsets": [ [ 51, 54 ] ], "normalized": [] }, { "id": "1.0alpha7.train.8.ent7_0", "type": "experiment-tag", "text": [ "Gst" ], "offsets": [ [ 40, 43 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.9
19792388
[ { "id": "1.0alpha7.train.9.sent", "type": "sentence", "text": [ "Cytoplasmic dynein binds the p150 Glued component of the dynactin complex through interaction between the NH2 terminus of its intermediate chains and the -helical coiled-coil region of p150 Glued ( Karki and Holzbaur, 1995; Vaughan and Vallee, 1995)." ], "offsets": [ [ 0, 250 ] ] } ]
[ { "id": "1.0alpha7.train.9.ent0_0", "type": "protein-complex", "text": [ "dynein" ], "offsets": [ [ 12, 18 ] ], "normalized": [] }, { "id": "1.0alpha7.train.9.ent1_0", "type": "protein", "text": [ "p150 Glued" ], "offsets": [ [ 29, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1639" }, { "db_name": "hgnc", "db_id": "DCTN1" }, { "db_name": "uniprot", "db_id": "E9PCY0" } ] }, { "id": "1.0alpha7.train.9.ent2_1", "type": "protein", "text": [ "p150 Glued" ], "offsets": [ [ 185, 195 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1639" }, { "db_name": "hgnc", "db_id": "DCTN1" }, { "db_name": "uniprot", "db_id": "E9PCY0" } ] }, { "id": "1.0alpha7.train.9.ent3_0", "type": "protein-complex", "text": [ "dynactin" ], "offsets": [ [ 57, 65 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.10
2679916
[ { "id": "1.0alpha7.train.10.sent", "type": "sentence", "text": [ "Structural features and RII binding assays suggest that amino acids 511-530 in DAKAP200 constitute an RII binding site." ], "offsets": [ [ 0, 119 ] ] } ]
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[]
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1.0alpha7.train.11
25223498
[ { "id": "1.0alpha7.train.11.sent", "type": "sentence", "text": [ "Mena binds directly to Profilin, an actin-binding protein that modulates actin polymerization." ], "offsets": [ [ 0, 94 ] ] } ]
[ { "id": "1.0alpha7.train.11.ent0_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 36, 41 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.11.ent1_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 73, 78 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.11.ent2_0", "type": "protein", "text": [ "Mena" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55740" }, { "db_name": "hgnc", "db_id": "ENAH" }, { "db_name": "uniprot", "db_id": "Q8N8S7" } ] }, { "id": "1.0alpha7.train.11.ent3_0", "type": "protein-family", "text": [ "Profilin" ], "offsets": [ [ 23, 31 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00235" } ] } ]
[]
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1.0alpha7.train.12
5083349
[ { "id": "1.0alpha7.train.12.sent", "type": "sentence", "text": [ "Mirk Binds to a Specific Region within the CBP-binding Region of HNF1α" ], "offsets": [ [ 0, 70 ] ] } ]
[ { "id": "1.0alpha7.train.12.ent0_0", "type": "protein", "text": [ "CBP" ], "offsets": [ [ 43, 46 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1387" }, { "db_name": "hgnc", "db_id": "CREBBP" }, { "db_name": "uniprot", "db_id": "Q92793" } ] }, { "id": "1.0alpha7.train.12.ent1_0", "type": "protein", "text": [ "HNF1α" ], "offsets": [ [ 65, 70 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6927" }, { "db_name": "hgnc", "db_id": "HNF1A" }, { "db_name": "uniprot", "db_id": "A0A087WYP0" } ] }, { "id": "1.0alpha7.train.12.ent2_0", "type": "protein", "text": [ "Mirk" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9149" }, { "db_name": "hgnc", "db_id": "DYRK1B" }, { "db_name": "uniprot", "db_id": "Q9Y463" } ] } ]
[]
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1.0alpha7.train.13
5083349
[ { "id": "1.0alpha7.train.13.sent", "type": "sentence", "text": [ "We next determined the regions of Mirk and HNF1α necessary for their interaction." ], "offsets": [ [ 0, 81 ] ] } ]
[ { "id": "1.0alpha7.train.13.ent0_0", "type": "protein", "text": [ "HNF1α" ], "offsets": [ [ 43, 48 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6927" }, { "db_name": "hgnc", "db_id": "HNF1A" }, { "db_name": "uniprot", "db_id": "A0A087WYP0" } ] }, { "id": "1.0alpha7.train.13.ent1_0", "type": "protein", "text": [ "Mirk" ], "offsets": [ [ 34, 38 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9149" }, { "db_name": "hgnc", "db_id": "DYRK1B" }, { "db_name": "uniprot", "db_id": "Q9Y463" } ] } ]
[]
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1.0alpha7.train.14
11694484
[ { "id": "1.0alpha7.train.14.sent", "type": "sentence", "text": [ "Both GD and Snk bind to heparin - Sepharose, providing a link between the pipe-defined ventral prepattern and the protease cascade." ], "offsets": [ [ 0, 131 ] ] } ]
[ { "id": "1.0alpha7.train.14.ent0_0", "type": "protein", "text": [ "GD" ], "offsets": [ [ 5, 7 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O62589" } ] }, { "id": "1.0alpha7.train.14.ent1_0", "type": "protein", "text": [ "Snk" ], "offsets": [ [ 12, 15 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P05049" } ] }, { "id": "1.0alpha7.train.14.ent2_0", "type": "chemical", "text": [ "heparin - Sepharose" ], "offsets": [ [ 24, 43 ] ], "normalized": [ { "db_name": "pubchem:substance", "db_id": "160778572" } ] } ]
[]
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1.0alpha7.train.15
18075455
[ { "id": "1.0alpha7.train.15.sent", "type": "sentence", "text": [ " All of these residues, except Ser45, are located close to site of cofilin implicated genetically in actin binding, suggesting they also form part of the actin-binding surface. " ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "1.0alpha7.train.15.ent0_0", "type": "protein", "text": [ "cofilin" ], "offsets": [ [ 68, 75 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1072" }, { "db_name": "hgnc", "db_id": "CFL1" }, { "db_name": "uniprot", "db_id": "P23528" } ] }, { "id": "1.0alpha7.train.15.ent1_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 103, 108 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.15.ent2_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 157, 162 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] } ]
[]
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1.0alpha7.train.16
19760877
[ { "id": "1.0alpha7.train.16.sent", "type": "sentence", "text": [ "We have shown that CES-1 can bind to Snail-binding sites/E-boxes in the egl-1 locus in vitro, which are required for the ability of the ces-2 lf mutation n732 to block the death of the NSM sister cells in vivo." ], "offsets": [ [ 0, 210 ] ] } ]
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[]
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1.0alpha7.train.17
19725957
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[]
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1.0alpha7.train.18
2972695
[ { "id": "1.0alpha7.train.18.sent", "type": "sentence", "text": [ "To elucidate the biological significance of NE-dlg-calmodulin interaction in a neuronal cell, we attempted to identify another cellular protein that binds to the region near the calmodulin binding site of NE-dlg by two-hybrid screening using a human brain cDNA library as the prey. " ], "offsets": [ [ 0, 282 ] ] } ]
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[]
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1.0alpha7.train.19
15275411
[ { "id": "1.0alpha7.train.19.sent", "type": "sentence", "text": [ "Can we speculate as to where Phyl might bind Sina?" ], "offsets": [ [ 0, 50 ] ] } ]
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[]
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1.0alpha7.train.20
23310850
[ { "id": "1.0alpha7.train.20.sent", "type": "sentence", "text": [ "The majority of dCLK is bound to CYC during a daily cycle." ], "offsets": [ [ 0, 60 ] ] } ]
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[]
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1.0alpha7.train.21
15755010
[ { "id": "1.0alpha7.train.21.sent", "type": "sentence", "text": [ "In these clones, binding of p16 to cdk4 and cdk6 abrogated binding of cyclin D1, p27 KIP1, and p21 WAF1/CIP1." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
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1.0alpha7.train.22
9725155
[ { "id": "1.0alpha7.train.22.sent", "type": "sentence", "text": [ "Whereas FK506 stimulates the binding of FKBP12 to calcineurin ( 42), stoichiometric quantities of FK506 dissociate FKBP12 from the ryanodine and IP3 receptors ( 11, 36)." ], "offsets": [ [ 0, 169 ] ] } ]
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[]
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1.0alpha7.train.23
23571761
[ { "id": "1.0alpha7.train.23.sent", "type": "sentence", "text": [ "For each binding reaction, 5 mug of GST-GTPase bound to 25 mul of glutathione-Sepharose beads was mixed with an aliquot of cell extract containing 1 mg of protein for 1 hr at 4 degrees C." ], "offsets": [ [ 0, 187 ] ] } ]
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[]
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1.0alpha7.train.24
15500177
[ { "id": "1.0alpha7.train.24.sent", "type": "sentence", "text": [ "The EGF-like domain of Aos binds directly to DER at the sSpi-binding site and interferes with the binding of sSpi to DER (Fig. 8B)." ], "offsets": [ [ 0, 131 ] ] } ]
[ { "id": "1.0alpha7.train.24.ent0_0", "type": "protein", "text": [ "DER" ], "offsets": [ [ 45, 48 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P04412" } ] }, { "id": "1.0alpha7.train.24.ent1_1", "type": "protein", "text": [ "DER" ], "offsets": [ [ 117, 120 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P04412" } ] }, { "id": "1.0alpha7.train.24.ent2_0", "type": "protein", "text": [ "Aos" ], "offsets": [ [ 23, 26 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q00805" } ] }, { "id": "1.0alpha7.train.24.ent3_0", "type": "protein-domain", "text": [ "EGF-like domain" ], "offsets": [ [ 4, 19 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000742" } ] }, { "id": "1.0alpha7.train.24.ent4_0", "type": "protein", "text": [ "sSpi" ], "offsets": [ [ 56, 60 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "A4V0W1" } ] }, { "id": "1.0alpha7.train.24.ent5_1", "type": "protein", "text": [ "sSpi" ], "offsets": [ [ 109, 113 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "A4V0W1" } ] } ]
[]
[ { "id": "1.0alpha7.train.24.coref0", "entity_ids": [ "1.0alpha7.train.24.ent0_0", "1.0alpha7.train.24.ent1_1" ] }, { "id": "1.0alpha7.train.24.coref1", "entity_ids": [ "1.0alpha7.train.24.ent2_0" ] }, { "id": "1.0alpha7.train.24.coref2", "entity_ids": [ "1.0alpha7.train.24.ent3_0" ] }, { "id": "1.0alpha7.train.24.coref3", "entity_ids": [ "1.0alpha7.train.24.ent4_0", "1.0alpha7.train.24.ent5_1" ] } ]
[ { "id": "1.0alpha7.train.24.rel0s1.0alpha7.train.24.ent0_0.o1.0alpha7.train.24.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent0_0", "arg2_id": "1.0alpha7.train.24.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.24.rel0s1.0alpha7.train.24.ent1_1.o1.0alpha7.train.24.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent1_1", "arg2_id": "1.0alpha7.train.24.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.24.rel1s1.0alpha7.train.24.ent0_0.o1.0alpha7.train.24.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent0_0", "arg2_id": "1.0alpha7.train.24.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.24.rel1s1.0alpha7.train.24.ent0_0.o1.0alpha7.train.24.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent0_0", "arg2_id": "1.0alpha7.train.24.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.24.rel1s1.0alpha7.train.24.ent1_1.o1.0alpha7.train.24.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent1_1", "arg2_id": "1.0alpha7.train.24.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.24.rel1s1.0alpha7.train.24.ent1_1.o1.0alpha7.train.24.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent1_1", "arg2_id": "1.0alpha7.train.24.ent5_1", "normalized": [] } ]
1.0alpha7.train.25
4281921
[ { "id": "1.0alpha7.train.25.sent", "type": "sentence", "text": [ "This site has been shown to be differentially protected by TGF-β treatment in experiments of DNA footprinting (data not shown), and in vivo positioning of Sp1 using the PINPOINT technique maps the Sp1 binding site over the predicted consensus sequence on endoglin promoter (Fig. 2 A). " ], "offsets": [ [ 0, 285 ] ] } ]
[ { "id": "1.0alpha7.train.25.ent0_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 155, 158 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.25.ent1_1", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 197, 200 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.25.ent2_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 93, 96 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.25.ent3_0", "type": "DNA", "text": [ "endoglin promoter" ], "offsets": [ [ 255, 272 ] ], "normalized": [] }, { "id": "1.0alpha7.train.25.ent4_0", "type": "protein", "text": [ "TGF-β" ], "offsets": [ [ 59, 64 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7040" }, { "db_name": "hgnc", "db_id": "TGFB1" }, { "db_name": "uniprot", "db_id": "NA" } ] } ]
[]
[ { "id": "1.0alpha7.train.25.coref0", "entity_ids": [ "1.0alpha7.train.25.ent0_0", "1.0alpha7.train.25.ent1_1" ] }, { "id": "1.0alpha7.train.25.coref1", "entity_ids": [ "1.0alpha7.train.25.ent2_0" ] }, { "id": "1.0alpha7.train.25.coref2", "entity_ids": [ "1.0alpha7.train.25.ent3_0" ] }, { "id": "1.0alpha7.train.25.coref3", "entity_ids": [ "1.0alpha7.train.25.ent4_0" ] } ]
[ { "id": "1.0alpha7.train.25.rel0s1.0alpha7.train.25.ent0_0.o1.0alpha7.train.25.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.25.ent0_0", "arg2_id": "1.0alpha7.train.25.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.25.rel0s1.0alpha7.train.25.ent1_1.o1.0alpha7.train.25.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.25.ent1_1", "arg2_id": "1.0alpha7.train.25.ent3_0", "normalized": [] } ]
1.0alpha7.train.26
9635775
[ { "id": "1.0alpha7.train.26.sent", "type": "sentence", "text": [ "To explore the functional significance of mitosis-specific phosphorylation of MYPT, the myosin binding activities of MYPT from mitotic or interphase cells were compared." ], "offsets": [ [ 0, 169 ] ] } ]
[ { "id": "1.0alpha7.train.26.ent0_0", "type": "protein-family", "text": [ "MYPT" ], "offsets": [ [ 78, 82 ] ], "normalized": [] }, { "id": "1.0alpha7.train.26.ent1_1", "type": "protein-family", "text": [ "MYPT" ], "offsets": [ [ 117, 121 ] ], "normalized": [] }, { "id": "1.0alpha7.train.26.ent2_0", "type": "protein-complex", "text": [ "myosin" ], "offsets": [ [ 88, 94 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.26.coref0", "entity_ids": [ "1.0alpha7.train.26.ent0_0", "1.0alpha7.train.26.ent1_1" ] }, { "id": "1.0alpha7.train.26.coref1", "entity_ids": [ "1.0alpha7.train.26.ent2_0" ] } ]
[ { "id": "1.0alpha7.train.26.rel0s1.0alpha7.train.26.ent0_0.o1.0alpha7.train.26.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.26.ent0_0", "arg2_id": "1.0alpha7.train.26.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.26.rel0s1.0alpha7.train.26.ent1_1.o1.0alpha7.train.26.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.26.ent1_1", "arg2_id": "1.0alpha7.train.26.ent2_0", "normalized": [] } ]
1.0alpha7.train.27
15954894
[ { "id": "1.0alpha7.train.27.sent", "type": "sentence", "text": [ "(C) Adf-1 binds the same regions of TAFII110 and TAFII250 in vivo as it does in vitro." ], "offsets": [ [ 0, 86 ] ] } ]
[ { "id": "1.0alpha7.train.27.ent0_0", "type": "protein", "text": [ "Adf-1" ], "offsets": [ [ 4, 9 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "A0A0B4KEJ0" } ] }, { "id": "1.0alpha7.train.27.ent1_0", "type": "protein", "text": [ "TAFII250" ], "offsets": [ [ 49, 57 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P51123" } ] }, { "id": "1.0alpha7.train.27.ent2_0", "type": "protein", "text": [ "TAFII110" ], "offsets": [ [ 36, 44 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P47825" } ] } ]
[]
[ { "id": "1.0alpha7.train.27.coref0", "entity_ids": [ "1.0alpha7.train.27.ent0_0" ] }, { "id": "1.0alpha7.train.27.coref1", "entity_ids": [ "1.0alpha7.train.27.ent1_0" ] }, { "id": "1.0alpha7.train.27.coref2", "entity_ids": [ "1.0alpha7.train.27.ent2_0" ] } ]
[ { "id": "1.0alpha7.train.27.rel0s1.0alpha7.train.27.ent0_0.o1.0alpha7.train.27.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.27.ent0_0", "arg2_id": "1.0alpha7.train.27.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.27.rel1s1.0alpha7.train.27.ent0_0.o1.0alpha7.train.27.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.27.ent0_0", "arg2_id": "1.0alpha7.train.27.ent1_0", "normalized": [] } ]
1.0alpha7.train.28
19845696
[ { "id": "1.0alpha7.train.28.sent", "type": "sentence", "text": [ "The intricate region was previously shown to contain functional Ets-1 in addition to CREB, LEF and ds binding sites." ], "offsets": [ [ 0, 116 ] ] } ]
[ { "id": "1.0alpha7.train.28.ent0_0", "type": "protein", "text": [ "CREB" ], "offsets": [ [ 85, 89 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1385" }, { "db_name": "hgnc", "db_id": "CREB1" }, { "db_name": "uniprot", "db_id": "P16220" } ] }, { "id": "1.0alpha7.train.28.ent1_0", "type": "protein", "text": [ "Ets-1" ], "offsets": [ [ 64, 69 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2113" }, { "db_name": "hgnc", "db_id": "ETS1" }, { "db_name": "uniprot", "db_id": "P14921" } ] }, { "id": "1.0alpha7.train.28.ent2_0", "type": "protein", "text": [ "LEF" ], "offsets": [ [ 91, 94 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "51176" }, { "db_name": "hgnc", "db_id": "LEF1" }, { "db_name": "uniprot", "db_id": "Q9UJU2" } ] } ]
[]
[ { "id": "1.0alpha7.train.28.coref0", "entity_ids": [ "1.0alpha7.train.28.ent0_0" ] }, { "id": "1.0alpha7.train.28.coref1", "entity_ids": [ "1.0alpha7.train.28.ent1_0" ] }, { "id": "1.0alpha7.train.28.coref2", "entity_ids": [ "1.0alpha7.train.28.ent2_0" ] } ]
[]
1.0alpha7.train.29
15179628
[ { "id": "1.0alpha7.train.29.sent", "type": "sentence", "text": [ "Inducer-specific binding of Ets-1 to the endogenous TNF-alpha promoter." ], "offsets": [ [ 0, 71 ] ] } ]
[ { "id": "1.0alpha7.train.29.ent0_0", "type": "DNA", "text": [ "TNF-alpha promoter" ], "offsets": [ [ 52, 70 ] ], "normalized": [] }, { "id": "1.0alpha7.train.29.ent1_0", "type": "protein", "text": [ "Ets-1" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2113" }, { "db_name": "hgnc", "db_id": "ETS1" }, { "db_name": "uniprot", "db_id": "P14921" } ] } ]
[]
[ { "id": "1.0alpha7.train.29.coref0", "entity_ids": [ "1.0alpha7.train.29.ent0_0" ] }, { "id": "1.0alpha7.train.29.coref1", "entity_ids": [ "1.0alpha7.train.29.ent1_0" ] } ]
[ { "id": "1.0alpha7.train.29.rel0s1.0alpha7.train.29.ent0_0.o1.0alpha7.train.29.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.29.ent0_0", "arg2_id": "1.0alpha7.train.29.ent1_0", "normalized": [] } ]
1.0alpha7.train.30
16352875
[ { "id": "1.0alpha7.train.30.sent", "type": "sentence", "text": [ "To test whether the cytoplasmic domains of other neuroligins also interact with PSD-95, and whether isoforms of PSD-95 also bind to neuroligins, we quantified the yeast two-hybrid interactions by measuring beta-galactosidase transactivation (Table 1)." ], "offsets": [ [ 0, 251 ] ] } ]
[ { "id": "1.0alpha7.train.30.ent0_0", "type": "protein-family", "text": [ "neuroligins" ], "offsets": [ [ 49, 60 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000460" } ] }, { "id": "1.0alpha7.train.30.ent1_1", "type": "protein-family", "text": [ "neuroligins" ], "offsets": [ [ 132, 143 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000460" } ] }, { "id": "1.0alpha7.train.30.ent2_0", "type": "protein-family", "text": [ "beta-galactosidase" ], "offsets": [ [ 206, 224 ] ], "normalized": [ { "db_name": "intenz", "db_id": "https://www.ebi.ac.uk/intenz/query?cmd" } ] }, { "id": "1.0alpha7.train.30.ent3_0", "type": "protein", "text": [ "PSD-95" ], "offsets": [ [ 80, 86 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1742" }, { "db_name": "hgnc", "db_id": "DLG4" }, { "db_name": "uniprot", "db_id": "P78352" } ] }, { "id": "1.0alpha7.train.30.ent4_1", "type": "protein", "text": [ "PSD-95" ], "offsets": [ [ 112, 118 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1742" }, { "db_name": "hgnc", "db_id": "DLG4" }, { "db_name": "uniprot", "db_id": "P78352" } ] } ]
[]
[ { "id": "1.0alpha7.train.30.coref0", "entity_ids": [ "1.0alpha7.train.30.ent0_0", "1.0alpha7.train.30.ent1_1" ] }, { "id": "1.0alpha7.train.30.coref1", "entity_ids": [ "1.0alpha7.train.30.ent2_0" ] }, { "id": "1.0alpha7.train.30.coref2", "entity_ids": [ "1.0alpha7.train.30.ent3_0", "1.0alpha7.train.30.ent4_1" ] } ]
[ { "id": "1.0alpha7.train.30.rel0s1.0alpha7.train.30.ent0_0.o1.0alpha7.train.30.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.30.ent0_0", "arg2_id": "1.0alpha7.train.30.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.30.rel0s1.0alpha7.train.30.ent0_0.o1.0alpha7.train.30.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.30.ent0_0", "arg2_id": "1.0alpha7.train.30.ent4_1", "normalized": [] }, { "id": "1.0alpha7.train.30.rel0s1.0alpha7.train.30.ent1_1.o1.0alpha7.train.30.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.30.ent1_1", "arg2_id": "1.0alpha7.train.30.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.30.rel0s1.0alpha7.train.30.ent1_1.o1.0alpha7.train.30.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.30.ent1_1", "arg2_id": "1.0alpha7.train.30.ent4_1", "normalized": [] } ]
1.0alpha7.train.31
3737303
[ { "id": "1.0alpha7.train.31.sent", "type": "sentence", "text": [ "DNA Binding of Smad5 and Smad4 to the GC-rich Sequence" ], "offsets": [ [ 0, 54 ] ] } ]