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1.0alpha7.train.0
24813911
[ { "id": "1.0alpha7.train.0.sent", "type": "sentence", "text": [ "Moreover, the in vitro binding of NF-κB or Sp1 to its target DNA was not affected by the presence of K-12." ], "offsets": [ [ 0, 106 ] ] } ]
[ { "id": "1.0alpha7.train.0.ent0_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 61, 64 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.0.ent1_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 43, 46 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.0.ent2_0", "type": "protein", "text": [ "NF-κB" ], "offsets": [ [ 34, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4790" }, { "db_name": "hgnc", "db_id": "NFKB1" }, { "db_name": "uniprot", "db_id": "P19838" } ] }, { "id": "1.0alpha7.train.0.ent3_0", "type": "chemical", "text": [ "K-12" ], "offsets": [ [ 101, 105 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "469668" } ] } ]
[]
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1.0alpha7.train.1
22578317
[ { "id": "1.0alpha7.train.1.sent", "type": "sentence", "text": [ "No appreciable binding of Ly49C to Db could be detected in the cell-cell adhesion assay by antibody blocking or by employing cells from Kb / mice that express Db normally ( Figure 3 and Figure 4)." ], "offsets": [ [ 0, 205 ] ] } ]
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[]
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[ { "id": "1.0alpha7.train.1.rel0s1.0alpha7.train.1.ent0_0.o1.0alpha7.train.1.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1.ent0_0", "arg2_id": "1.0alpha7.train.1.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.1.rel0s1.0alpha7.train.1.ent1_1.o1.0alpha7.train.1.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.1.ent1_1", "arg2_id": "1.0alpha7.train.1.ent2_0", "normalized": [] } ]
1.0alpha7.train.2
9378102
[ { "id": "1.0alpha7.train.2.sent", "type": "sentence", "text": [ "The yeast two-hybrid interaction assays indicated that filamin-A does not bind to any integrin β subunit, whereas filamin-B only interacts with β1A." ], "offsets": [ [ 0, 148 ] ] } ]
[ { "id": "1.0alpha7.train.2.ent0_0", "type": "protein", "text": [ "filamin-A" ], "offsets": [ [ 55, 64 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2316" }, { "db_name": "hgnc", "db_id": "FLNA" }, { "db_name": "uniprot", "db_id": "P21333" } ] }, { "id": "1.0alpha7.train.2.ent1_0", "type": "protein", "text": [ "filamin-B" ], "offsets": [ [ 114, 123 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2317" }, { "db_name": "hgnc", "db_id": "FLNB" }, { "db_name": "uniprot", "db_id": "O75369" } ] }, { "id": "1.0alpha7.train.2.ent2_0", "type": "protein", "text": [ "integrin β" ], "offsets": [ [ 86, 96 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2247" }, { "db_name": "hgnc", "db_id": "FGF2" }, { "db_name": "uniprot", "db_id": "P09038" } ] }, { "id": "1.0alpha7.train.2.ent3_0", "type": "protein-isoform", "text": [ "β1A" ], "offsets": [ [ 144, 147 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.3
16358135
[ { "id": "1.0alpha7.train.3.sent", "type": "sentence", "text": [ " Because FLICE2 does not directly bind DR4 or DR5, a yet to be identified adaptor molecule is presumably responsible for this linkage. " ], "offsets": [ [ 0, 139 ] ] } ]
[ { "id": "1.0alpha7.train.3.ent0_0", "type": "protein", "text": [ "DR5" ], "offsets": [ [ 49, 52 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8795" }, { "db_name": "hgnc", "db_id": "TNFRSF10B" }, { "db_name": "uniprot", "db_id": "O14763" } ] }, { "id": "1.0alpha7.train.3.ent1_0", "type": "protein", "text": [ "FLICE2" ], "offsets": [ [ 10, 16 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "843" }, { "db_name": "hgnc", "db_id": "CASP10" }, { "db_name": "uniprot", "db_id": "Q92851" } ] }, { "id": "1.0alpha7.train.3.ent2_0", "type": "protein", "text": [ "DR4" ], "offsets": [ [ 41, 44 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8797" }, { "db_name": "hgnc", "db_id": "TNFRSF10A" }, { "db_name": "uniprot", "db_id": "O00220" } ] } ]
[]
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[ { "id": "1.0alpha7.train.3.rel0s1.0alpha7.train.3.ent1_0.o1.0alpha7.train.3.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.3.ent1_0", "arg2_id": "1.0alpha7.train.3.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.3.rel1s1.0alpha7.train.3.ent0_0.o1.0alpha7.train.3.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.3.ent0_0", "arg2_id": "1.0alpha7.train.3.ent1_0", "normalized": [] } ]
1.0alpha7.train.4
2062980
[ { "id": "1.0alpha7.train.4.sent", "type": "sentence", "text": [ "We have thus examined whether actin binding of fascin can be regulated in a calcium-dependent way by controlling actin binding of caldesmon with Ca2+/calmodulin." ], "offsets": [ [ 0, 161 ] ] } ]
[ { "id": "1.0alpha7.train.4.ent0_0", "type": "protein", "text": [ "calmodulin" ], "offsets": [ [ 150, 160 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "801" }, { "db_name": "hgnc", "db_id": "CALM1" }, { "db_name": "uniprot", "db_id": "P0DP23" } ] }, { "id": "1.0alpha7.train.4.ent1_0", "type": "protein", "text": [ "Ca2+/calmodulin" ], "offsets": [ [ 145, 160 ] ], "normalized": [] }, { "id": "1.0alpha7.train.4.ent2_0", "type": "chemical", "text": [ "Ca2+" ], "offsets": [ [ 145, 149 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.4.ent3_0", "type": "chemical", "text": [ "calcium" ], "offsets": [ [ 76, 83 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.4.ent4_0", "type": "protein", "text": [ "fascin" ], "offsets": [ [ 47, 53 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6624" }, { "db_name": "hgnc", "db_id": "FSCN1" }, { "db_name": "uniprot", "db_id": "C9JPH9" } ] }, { "id": "1.0alpha7.train.4.ent5_0", "type": "protein", "text": [ "caldesmon" ], "offsets": [ [ 130, 139 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "800" }, { "db_name": "hgnc", "db_id": "CALD1" }, { "db_name": "uniprot", "db_id": "E9PGZ1" } ] }, { "id": "1.0alpha7.train.4.ent6_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 30, 35 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.4.ent7_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 113, 118 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] } ]
[]
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1.0alpha7.train.5
609763
[ { "id": "1.0alpha7.train.5.sent", "type": "sentence", "text": [ "Therefore, we cannot rule out that some variations in the binding of three apoE isotypes to Abeta peptides will be found when other apoE preparations are used." ], "offsets": [ [ 0, 159 ] ] } ]
[ { "id": "1.0alpha7.train.5.ent0_0", "type": "protein", "text": [ "apoE" ], "offsets": [ [ 75, 79 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "348" }, { "db_name": "hgnc", "db_id": "APOE" }, { "db_name": "uniprot", "db_id": "P02649" } ] }, { "id": "1.0alpha7.train.5.ent1_1", "type": "protein", "text": [ "apoE" ], "offsets": [ [ 132, 136 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "348" }, { "db_name": "hgnc", "db_id": "APOE" }, { "db_name": "uniprot", "db_id": "P02649" } ] }, { "id": "1.0alpha7.train.5.ent2_0", "type": "peptide", "text": [ "Abeta" ], "offsets": [ [ 92, 97 ] ], "normalized": [] } ]
[]
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[ { "id": "1.0alpha7.train.5.rel0s1.0alpha7.train.5.ent0_0.o1.0alpha7.train.5.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.5.ent0_0", "arg2_id": "1.0alpha7.train.5.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.5.rel0s1.0alpha7.train.5.ent1_1.o1.0alpha7.train.5.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.5.ent1_1", "arg2_id": "1.0alpha7.train.5.ent2_0", "normalized": [] } ]
1.0alpha7.train.6
2062658
[ { "id": "1.0alpha7.train.6.sent", "type": "sentence", "text": [ "When calmodulin is added, the inhibition of fascin-actin interaction by caldesmon and TM becomes Ca2+ dependent because Ca2+/calmodulin blocks actin binding of caldesmon." ], "offsets": [ [ 0, 177 ] ] } ]
[ { "id": "1.0alpha7.train.6.ent0_0", "type": "protein", "text": [ "calmodulin" ], "offsets": [ [ 6, 16 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "801" }, { "db_name": "hgnc", "db_id": "CALM1" }, { "db_name": "uniprot", "db_id": "P0DP23" } ] }, { "id": "1.0alpha7.train.6.ent1_1", "type": "protein", "text": [ "calmodulin" ], "offsets": [ [ 130, 140 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "801" }, { "db_name": "hgnc", "db_id": "CALM1" }, { "db_name": "uniprot", "db_id": "P0DP23" } ] }, { "id": "1.0alpha7.train.6.ent2_0", "type": "chemical", "text": [ "Ca2+" ], "offsets": [ [ 101, 105 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.6.ent3_1", "type": "chemical", "text": [ "Ca2+" ], "offsets": [ [ 125, 129 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.6.ent4_0", "type": "protein", "text": [ "Ca2+/calmodulin" ], "offsets": [ [ 125, 140 ] ], "normalized": [] }, { "id": "1.0alpha7.train.6.ent5_0", "type": "protein", "text": [ "fascin" ], "offsets": [ [ 46, 52 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6624" }, { "db_name": "hgnc", "db_id": "FSCN1" }, { "db_name": "uniprot", "db_id": "C9JPH9" } ] }, { "id": "1.0alpha7.train.6.ent6_0", "type": "protein", "text": [ "caldesmon" ], "offsets": [ [ 75, 84 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "800" }, { "db_name": "hgnc", "db_id": "CALD1" }, { "db_name": "uniprot", "db_id": "E9PGZ1" } ] }, { "id": "1.0alpha7.train.6.ent7_1", "type": "protein", "text": [ "caldesmon" ], "offsets": [ [ 167, 176 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "800" }, { "db_name": "hgnc", "db_id": "CALD1" }, { "db_name": "uniprot", "db_id": "E9PGZ1" } ] }, { "id": "1.0alpha7.train.6.ent8_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 53, 58 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.6.ent9_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 149, 154 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] } ]
[]
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[ { "id": "1.0alpha7.train.6.rel0s1.0alpha7.train.6.ent5_0.o1.0alpha7.train.6.ent8_0", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent5_0", "arg2_id": "1.0alpha7.train.6.ent8_0", "normalized": [] }, { "id": "1.0alpha7.train.6.rel0s1.0alpha7.train.6.ent5_0.o1.0alpha7.train.6.ent9_1", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent5_0", "arg2_id": "1.0alpha7.train.6.ent9_1", "normalized": [] }, { "id": "1.0alpha7.train.6.rel1s1.0alpha7.train.6.ent6_0.o1.0alpha7.train.6.ent8_0", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent6_0", "arg2_id": "1.0alpha7.train.6.ent8_0", "normalized": [] }, { "id": "1.0alpha7.train.6.rel1s1.0alpha7.train.6.ent6_0.o1.0alpha7.train.6.ent9_1", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent6_0", "arg2_id": "1.0alpha7.train.6.ent9_1", "normalized": [] }, { "id": "1.0alpha7.train.6.rel1s1.0alpha7.train.6.ent7_1.o1.0alpha7.train.6.ent8_0", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent7_1", "arg2_id": "1.0alpha7.train.6.ent8_0", "normalized": [] }, { "id": "1.0alpha7.train.6.rel1s1.0alpha7.train.6.ent7_1.o1.0alpha7.train.6.ent9_1", "type": "bind", "arg1_id": "1.0alpha7.train.6.ent7_1", "arg2_id": "1.0alpha7.train.6.ent9_1", "normalized": [] } ]
1.0alpha7.train.7
7056113
[ { "id": "1.0alpha7.train.7.sent", "type": "sentence", "text": [ "Briefly, the oligonucleotide library was incubated with fusion proteins bound to either GST-coated bead-bound fusion proteins (GST-tag) or nickel/nitrilotriacetic acid matrix-bound fusion proteins (histidine-tag) in a buffer containing 20 mM Tris (pH 8.0), 50 mM KCl, 1 mM DTT, 0.5 mM EDTA, 10% glycerol, 20 μg/ml BSA, and 2 μg/ml poly(dI)⋅poly(dc)." ], "offsets": [ [ 0, 349 ] ] } ]
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[]
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[]
1.0alpha7.train.8
15405236
[ { "id": "1.0alpha7.train.8.sent", "type": "sentence", "text": [ "Extracts were incubated with 20 mug of Gst-RalGDS-RBD precoupled to gluthathione beads to isolate GTP-bound (activated) Rap1." ], "offsets": [ [ 0, 128 ] ] } ]
[ { "id": "1.0alpha7.train.8.ent0_0", "type": "protein", "text": [ "RalGDS" ], "offsets": [ [ 44, 50 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5900" }, { "db_name": "hgnc", "db_id": "RALGDS" }, { "db_name": "uniprot", "db_id": "Q12967" } ] }, { "id": "1.0alpha7.train.8.ent1_0", "type": "chemical", "text": [ "gluthathione" ], "offsets": [ [ 69, 81 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "124886" } ] }, { "id": "1.0alpha7.train.8.ent2_0", "type": "protein", "text": [ "Rap1" ], "offsets": [ [ 123, 127 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5906" }, { "db_name": "hgnc", "db_id": "RAP1A" }, { "db_name": "uniprot", "db_id": "P62834" } ] }, { "id": "1.0alpha7.train.8.ent3_0", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 100, 103 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.8.ent4_0", "type": "protein", "text": [ "(activated) Rap1" ], "offsets": [ [ 110, 127 ] ], "normalized": [] }, { "id": "1.0alpha7.train.8.ent5_0", "type": "fusion-protein", "text": [ "Gst-RalGDS-RBD" ], "offsets": [ [ 40, 54 ] ], "normalized": [] }, { "id": "1.0alpha7.train.8.ent6_0", "type": "protein-domain", "text": [ "RBD" ], "offsets": [ [ 51, 54 ] ], "normalized": [] }, { "id": "1.0alpha7.train.8.ent7_0", "type": "experiment-tag", "text": [ "Gst" ], "offsets": [ [ 40, 43 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.9
19792388
[ { "id": "1.0alpha7.train.9.sent", "type": "sentence", "text": [ "Cytoplasmic dynein binds the p150 Glued component of the dynactin complex through interaction between the NH2 terminus of its intermediate chains and the -helical coiled-coil region of p150 Glued ( Karki and Holzbaur, 1995; Vaughan and Vallee, 1995)." ], "offsets": [ [ 0, 250 ] ] } ]
[ { "id": "1.0alpha7.train.9.ent0_0", "type": "protein-complex", "text": [ "dynein" ], "offsets": [ [ 12, 18 ] ], "normalized": [] }, { "id": "1.0alpha7.train.9.ent1_0", "type": "protein", "text": [ "p150 Glued" ], "offsets": [ [ 29, 39 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1639" }, { "db_name": "hgnc", "db_id": "DCTN1" }, { "db_name": "uniprot", "db_id": "E9PCY0" } ] }, { "id": "1.0alpha7.train.9.ent2_1", "type": "protein", "text": [ "p150 Glued" ], "offsets": [ [ 185, 195 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1639" }, { "db_name": "hgnc", "db_id": "DCTN1" }, { "db_name": "uniprot", "db_id": "E9PCY0" } ] }, { "id": "1.0alpha7.train.9.ent3_0", "type": "protein-complex", "text": [ "dynactin" ], "offsets": [ [ 57, 65 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.10
2679916
[ { "id": "1.0alpha7.train.10.sent", "type": "sentence", "text": [ "Structural features and RII binding assays suggest that amino acids 511-530 in DAKAP200 constitute an RII binding site." ], "offsets": [ [ 0, 119 ] ] } ]
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[]
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1.0alpha7.train.11
25223498
[ { "id": "1.0alpha7.train.11.sent", "type": "sentence", "text": [ "Mena binds directly to Profilin, an actin-binding protein that modulates actin polymerization." ], "offsets": [ [ 0, 94 ] ] } ]
[ { "id": "1.0alpha7.train.11.ent0_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 36, 41 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.11.ent1_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 73, 78 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.11.ent2_0", "type": "protein", "text": [ "Mena" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55740" }, { "db_name": "hgnc", "db_id": "ENAH" }, { "db_name": "uniprot", "db_id": "Q8N8S7" } ] }, { "id": "1.0alpha7.train.11.ent3_0", "type": "protein-family", "text": [ "Profilin" ], "offsets": [ [ 23, 31 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00235" } ] } ]
[]
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1.0alpha7.train.12
5083349
[ { "id": "1.0alpha7.train.12.sent", "type": "sentence", "text": [ "Mirk Binds to a Specific Region within the CBP-binding Region of HNF1α" ], "offsets": [ [ 0, 70 ] ] } ]
[ { "id": "1.0alpha7.train.12.ent0_0", "type": "protein", "text": [ "CBP" ], "offsets": [ [ 43, 46 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1387" }, { "db_name": "hgnc", "db_id": "CREBBP" }, { "db_name": "uniprot", "db_id": "Q92793" } ] }, { "id": "1.0alpha7.train.12.ent1_0", "type": "protein", "text": [ "HNF1α" ], "offsets": [ [ 65, 70 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6927" }, { "db_name": "hgnc", "db_id": "HNF1A" }, { "db_name": "uniprot", "db_id": "A0A087WYP0" } ] }, { "id": "1.0alpha7.train.12.ent2_0", "type": "protein", "text": [ "Mirk" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9149" }, { "db_name": "hgnc", "db_id": "DYRK1B" }, { "db_name": "uniprot", "db_id": "Q9Y463" } ] } ]
[]
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1.0alpha7.train.13
5083349
[ { "id": "1.0alpha7.train.13.sent", "type": "sentence", "text": [ "We next determined the regions of Mirk and HNF1α necessary for their interaction." ], "offsets": [ [ 0, 81 ] ] } ]
[ { "id": "1.0alpha7.train.13.ent0_0", "type": "protein", "text": [ "HNF1α" ], "offsets": [ [ 43, 48 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6927" }, { "db_name": "hgnc", "db_id": "HNF1A" }, { "db_name": "uniprot", "db_id": "A0A087WYP0" } ] }, { "id": "1.0alpha7.train.13.ent1_0", "type": "protein", "text": [ "Mirk" ], "offsets": [ [ 34, 38 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9149" }, { "db_name": "hgnc", "db_id": "DYRK1B" }, { "db_name": "uniprot", "db_id": "Q9Y463" } ] } ]
[]
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1.0alpha7.train.14
11694484
[ { "id": "1.0alpha7.train.14.sent", "type": "sentence", "text": [ "Both GD and Snk bind to heparin - Sepharose, providing a link between the pipe-defined ventral prepattern and the protease cascade." ], "offsets": [ [ 0, 131 ] ] } ]
[ { "id": "1.0alpha7.train.14.ent0_0", "type": "protein", "text": [ "GD" ], "offsets": [ [ 5, 7 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O62589" } ] }, { "id": "1.0alpha7.train.14.ent1_0", "type": "protein", "text": [ "Snk" ], "offsets": [ [ 12, 15 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P05049" } ] }, { "id": "1.0alpha7.train.14.ent2_0", "type": "chemical", "text": [ "heparin - Sepharose" ], "offsets": [ [ 24, 43 ] ], "normalized": [ { "db_name": "pubchem:substance", "db_id": "160778572" } ] } ]
[]
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1.0alpha7.train.15
18075455
[ { "id": "1.0alpha7.train.15.sent", "type": "sentence", "text": [ " All of these residues, except Ser45, are located close to site of cofilin implicated genetically in actin binding, suggesting they also form part of the actin-binding surface. " ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "1.0alpha7.train.15.ent0_0", "type": "protein", "text": [ "cofilin" ], "offsets": [ [ 68, 75 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1072" }, { "db_name": "hgnc", "db_id": "CFL1" }, { "db_name": "uniprot", "db_id": "P23528" } ] }, { "id": "1.0alpha7.train.15.ent1_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 103, 108 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] }, { "id": "1.0alpha7.train.15.ent2_1", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 157, 162 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] } ]
[]
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1.0alpha7.train.16
19760877
[ { "id": "1.0alpha7.train.16.sent", "type": "sentence", "text": [ "We have shown that CES-1 can bind to Snail-binding sites/E-boxes in the egl-1 locus in vitro, which are required for the ability of the ces-2 lf mutation n732 to block the death of the NSM sister cells in vivo." ], "offsets": [ [ 0, 210 ] ] } ]
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[]
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1.0alpha7.train.17
19725957
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[]
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1.0alpha7.train.18
2972695
[ { "id": "1.0alpha7.train.18.sent", "type": "sentence", "text": [ "To elucidate the biological significance of NE-dlg-calmodulin interaction in a neuronal cell, we attempted to identify another cellular protein that binds to the region near the calmodulin binding site of NE-dlg by two-hybrid screening using a human brain cDNA library as the prey. " ], "offsets": [ [ 0, 282 ] ] } ]
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[]
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1.0alpha7.train.19
15275411
[ { "id": "1.0alpha7.train.19.sent", "type": "sentence", "text": [ "Can we speculate as to where Phyl might bind Sina?" ], "offsets": [ [ 0, 50 ] ] } ]
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[]
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1.0alpha7.train.20
23310850
[ { "id": "1.0alpha7.train.20.sent", "type": "sentence", "text": [ "The majority of dCLK is bound to CYC during a daily cycle." ], "offsets": [ [ 0, 60 ] ] } ]
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[]
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1.0alpha7.train.21
15755010
[ { "id": "1.0alpha7.train.21.sent", "type": "sentence", "text": [ "In these clones, binding of p16 to cdk4 and cdk6 abrogated binding of cyclin D1, p27 KIP1, and p21 WAF1/CIP1." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
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1.0alpha7.train.22
9725155
[ { "id": "1.0alpha7.train.22.sent", "type": "sentence", "text": [ "Whereas FK506 stimulates the binding of FKBP12 to calcineurin ( 42), stoichiometric quantities of FK506 dissociate FKBP12 from the ryanodine and IP3 receptors ( 11, 36)." ], "offsets": [ [ 0, 169 ] ] } ]
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[]
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1.0alpha7.train.23
23571761
[ { "id": "1.0alpha7.train.23.sent", "type": "sentence", "text": [ "For each binding reaction, 5 mug of GST-GTPase bound to 25 mul of glutathione-Sepharose beads was mixed with an aliquot of cell extract containing 1 mg of protein for 1 hr at 4 degrees C." ], "offsets": [ [ 0, 187 ] ] } ]
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[]
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1.0alpha7.train.24
15500177
[ { "id": "1.0alpha7.train.24.sent", "type": "sentence", "text": [ "The EGF-like domain of Aos binds directly to DER at the sSpi-binding site and interferes with the binding of sSpi to DER (Fig. 8B)." ], "offsets": [ [ 0, 131 ] ] } ]
[ { "id": "1.0alpha7.train.24.ent0_0", "type": "protein", "text": [ "DER" ], "offsets": [ [ 45, 48 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P04412" } ] }, { "id": "1.0alpha7.train.24.ent1_1", "type": "protein", "text": [ "DER" ], "offsets": [ [ 117, 120 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P04412" } ] }, { "id": "1.0alpha7.train.24.ent2_0", "type": "protein", "text": [ "Aos" ], "offsets": [ [ 23, 26 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q00805" } ] }, { "id": "1.0alpha7.train.24.ent3_0", "type": "protein-domain", "text": [ "EGF-like domain" ], "offsets": [ [ 4, 19 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000742" } ] }, { "id": "1.0alpha7.train.24.ent4_0", "type": "protein", "text": [ "sSpi" ], "offsets": [ [ 56, 60 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "A4V0W1" } ] }, { "id": "1.0alpha7.train.24.ent5_1", "type": "protein", "text": [ "sSpi" ], "offsets": [ [ 109, 113 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "A4V0W1" } ] } ]
[]
[ { "id": "1.0alpha7.train.24.coref0", "entity_ids": [ "1.0alpha7.train.24.ent0_0", "1.0alpha7.train.24.ent1_1" ] }, { "id": "1.0alpha7.train.24.coref1", "entity_ids": [ "1.0alpha7.train.24.ent2_0" ] }, { "id": "1.0alpha7.train.24.coref2", "entity_ids": [ "1.0alpha7.train.24.ent3_0" ] }, { "id": "1.0alpha7.train.24.coref3", "entity_ids": [ "1.0alpha7.train.24.ent4_0", "1.0alpha7.train.24.ent5_1" ] } ]
[ { "id": "1.0alpha7.train.24.rel0s1.0alpha7.train.24.ent0_0.o1.0alpha7.train.24.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent0_0", "arg2_id": "1.0alpha7.train.24.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.24.rel0s1.0alpha7.train.24.ent1_1.o1.0alpha7.train.24.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent1_1", "arg2_id": "1.0alpha7.train.24.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.24.rel1s1.0alpha7.train.24.ent0_0.o1.0alpha7.train.24.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent0_0", "arg2_id": "1.0alpha7.train.24.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.24.rel1s1.0alpha7.train.24.ent0_0.o1.0alpha7.train.24.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent0_0", "arg2_id": "1.0alpha7.train.24.ent5_1", "normalized": [] }, { "id": "1.0alpha7.train.24.rel1s1.0alpha7.train.24.ent1_1.o1.0alpha7.train.24.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent1_1", "arg2_id": "1.0alpha7.train.24.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.24.rel1s1.0alpha7.train.24.ent1_1.o1.0alpha7.train.24.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.24.ent1_1", "arg2_id": "1.0alpha7.train.24.ent5_1", "normalized": [] } ]
1.0alpha7.train.25
4281921
[ { "id": "1.0alpha7.train.25.sent", "type": "sentence", "text": [ "This site has been shown to be differentially protected by TGF-β treatment in experiments of DNA footprinting (data not shown), and in vivo positioning of Sp1 using the PINPOINT technique maps the Sp1 binding site over the predicted consensus sequence on endoglin promoter (Fig. 2 A). " ], "offsets": [ [ 0, 285 ] ] } ]
[ { "id": "1.0alpha7.train.25.ent0_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 155, 158 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.25.ent1_1", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 197, 200 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.25.ent2_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 93, 96 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.25.ent3_0", "type": "DNA", "text": [ "endoglin promoter" ], "offsets": [ [ 255, 272 ] ], "normalized": [] }, { "id": "1.0alpha7.train.25.ent4_0", "type": "protein", "text": [ "TGF-β" ], "offsets": [ [ 59, 64 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7040" }, { "db_name": "hgnc", "db_id": "TGFB1" }, { "db_name": "uniprot", "db_id": "NA" } ] } ]
[]
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[ { "id": "1.0alpha7.train.25.rel0s1.0alpha7.train.25.ent0_0.o1.0alpha7.train.25.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.25.ent0_0", "arg2_id": "1.0alpha7.train.25.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.25.rel0s1.0alpha7.train.25.ent1_1.o1.0alpha7.train.25.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.25.ent1_1", "arg2_id": "1.0alpha7.train.25.ent3_0", "normalized": [] } ]
1.0alpha7.train.26
9635775
[ { "id": "1.0alpha7.train.26.sent", "type": "sentence", "text": [ "To explore the functional significance of mitosis-specific phosphorylation of MYPT, the myosin binding activities of MYPT from mitotic or interphase cells were compared." ], "offsets": [ [ 0, 169 ] ] } ]
[ { "id": "1.0alpha7.train.26.ent0_0", "type": "protein-family", "text": [ "MYPT" ], "offsets": [ [ 78, 82 ] ], "normalized": [] }, { "id": "1.0alpha7.train.26.ent1_1", "type": "protein-family", "text": [ "MYPT" ], "offsets": [ [ 117, 121 ] ], "normalized": [] }, { "id": "1.0alpha7.train.26.ent2_0", "type": "protein-complex", "text": [ "myosin" ], "offsets": [ [ 88, 94 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.26.coref0", "entity_ids": [ "1.0alpha7.train.26.ent0_0", "1.0alpha7.train.26.ent1_1" ] }, { "id": "1.0alpha7.train.26.coref1", "entity_ids": [ "1.0alpha7.train.26.ent2_0" ] } ]
[ { "id": "1.0alpha7.train.26.rel0s1.0alpha7.train.26.ent0_0.o1.0alpha7.train.26.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.26.ent0_0", "arg2_id": "1.0alpha7.train.26.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.26.rel0s1.0alpha7.train.26.ent1_1.o1.0alpha7.train.26.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.26.ent1_1", "arg2_id": "1.0alpha7.train.26.ent2_0", "normalized": [] } ]
1.0alpha7.train.27
15954894
[ { "id": "1.0alpha7.train.27.sent", "type": "sentence", "text": [ "(C) Adf-1 binds the same regions of TAFII110 and TAFII250 in vivo as it does in vitro." ], "offsets": [ [ 0, 86 ] ] } ]
[ { "id": "1.0alpha7.train.27.ent0_0", "type": "protein", "text": [ "Adf-1" ], "offsets": [ [ 4, 9 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "A0A0B4KEJ0" } ] }, { "id": "1.0alpha7.train.27.ent1_0", "type": "protein", "text": [ "TAFII250" ], "offsets": [ [ 49, 57 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P51123" } ] }, { "id": "1.0alpha7.train.27.ent2_0", "type": "protein", "text": [ "TAFII110" ], "offsets": [ [ 36, 44 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P47825" } ] } ]
[]
[ { "id": "1.0alpha7.train.27.coref0", "entity_ids": [ "1.0alpha7.train.27.ent0_0" ] }, { "id": "1.0alpha7.train.27.coref1", "entity_ids": [ "1.0alpha7.train.27.ent1_0" ] }, { "id": "1.0alpha7.train.27.coref2", "entity_ids": [ "1.0alpha7.train.27.ent2_0" ] } ]
[ { "id": "1.0alpha7.train.27.rel0s1.0alpha7.train.27.ent0_0.o1.0alpha7.train.27.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.27.ent0_0", "arg2_id": "1.0alpha7.train.27.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.27.rel1s1.0alpha7.train.27.ent0_0.o1.0alpha7.train.27.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.27.ent0_0", "arg2_id": "1.0alpha7.train.27.ent1_0", "normalized": [] } ]
1.0alpha7.train.28
19845696
[ { "id": "1.0alpha7.train.28.sent", "type": "sentence", "text": [ "The intricate region was previously shown to contain functional Ets-1 in addition to CREB, LEF and ds binding sites." ], "offsets": [ [ 0, 116 ] ] } ]
[ { "id": "1.0alpha7.train.28.ent0_0", "type": "protein", "text": [ "CREB" ], "offsets": [ [ 85, 89 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1385" }, { "db_name": "hgnc", "db_id": "CREB1" }, { "db_name": "uniprot", "db_id": "P16220" } ] }, { "id": "1.0alpha7.train.28.ent1_0", "type": "protein", "text": [ "Ets-1" ], "offsets": [ [ 64, 69 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2113" }, { "db_name": "hgnc", "db_id": "ETS1" }, { "db_name": "uniprot", "db_id": "P14921" } ] }, { "id": "1.0alpha7.train.28.ent2_0", "type": "protein", "text": [ "LEF" ], "offsets": [ [ 91, 94 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "51176" }, { "db_name": "hgnc", "db_id": "LEF1" }, { "db_name": "uniprot", "db_id": "Q9UJU2" } ] } ]
[]
[ { "id": "1.0alpha7.train.28.coref0", "entity_ids": [ "1.0alpha7.train.28.ent0_0" ] }, { "id": "1.0alpha7.train.28.coref1", "entity_ids": [ "1.0alpha7.train.28.ent1_0" ] }, { "id": "1.0alpha7.train.28.coref2", "entity_ids": [ "1.0alpha7.train.28.ent2_0" ] } ]
[]
1.0alpha7.train.29
15179628
[ { "id": "1.0alpha7.train.29.sent", "type": "sentence", "text": [ "Inducer-specific binding of Ets-1 to the endogenous TNF-alpha promoter." ], "offsets": [ [ 0, 71 ] ] } ]
[ { "id": "1.0alpha7.train.29.ent0_0", "type": "DNA", "text": [ "TNF-alpha promoter" ], "offsets": [ [ 52, 70 ] ], "normalized": [] }, { "id": "1.0alpha7.train.29.ent1_0", "type": "protein", "text": [ "Ets-1" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2113" }, { "db_name": "hgnc", "db_id": "ETS1" }, { "db_name": "uniprot", "db_id": "P14921" } ] } ]
[]
[ { "id": "1.0alpha7.train.29.coref0", "entity_ids": [ "1.0alpha7.train.29.ent0_0" ] }, { "id": "1.0alpha7.train.29.coref1", "entity_ids": [ "1.0alpha7.train.29.ent1_0" ] } ]
[ { "id": "1.0alpha7.train.29.rel0s1.0alpha7.train.29.ent0_0.o1.0alpha7.train.29.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.29.ent0_0", "arg2_id": "1.0alpha7.train.29.ent1_0", "normalized": [] } ]
1.0alpha7.train.30
16352875
[ { "id": "1.0alpha7.train.30.sent", "type": "sentence", "text": [ "To test whether the cytoplasmic domains of other neuroligins also interact with PSD-95, and whether isoforms of PSD-95 also bind to neuroligins, we quantified the yeast two-hybrid interactions by measuring beta-galactosidase transactivation (Table 1)." ], "offsets": [ [ 0, 251 ] ] } ]
[ { "id": "1.0alpha7.train.30.ent0_0", "type": "protein-family", "text": [ "neuroligins" ], "offsets": [ [ 49, 60 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000460" } ] }, { "id": "1.0alpha7.train.30.ent1_1", "type": "protein-family", "text": [ "neuroligins" ], "offsets": [ [ 132, 143 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000460" } ] }, { "id": "1.0alpha7.train.30.ent2_0", "type": "protein-family", "text": [ "beta-galactosidase" ], "offsets": [ [ 206, 224 ] ], "normalized": [ { "db_name": "intenz", "db_id": "https://www.ebi.ac.uk/intenz/query?cmd" } ] }, { "id": "1.0alpha7.train.30.ent3_0", "type": "protein", "text": [ "PSD-95" ], "offsets": [ [ 80, 86 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1742" }, { "db_name": "hgnc", "db_id": "DLG4" }, { "db_name": "uniprot", "db_id": "P78352" } ] }, { "id": "1.0alpha7.train.30.ent4_1", "type": "protein", "text": [ "PSD-95" ], "offsets": [ [ 112, 118 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1742" }, { "db_name": "hgnc", "db_id": "DLG4" }, { "db_name": "uniprot", "db_id": "P78352" } ] } ]
[]
[ { "id": "1.0alpha7.train.30.coref0", "entity_ids": [ "1.0alpha7.train.30.ent0_0", "1.0alpha7.train.30.ent1_1" ] }, { "id": "1.0alpha7.train.30.coref1", "entity_ids": [ "1.0alpha7.train.30.ent2_0" ] }, { "id": "1.0alpha7.train.30.coref2", "entity_ids": [ "1.0alpha7.train.30.ent3_0", "1.0alpha7.train.30.ent4_1" ] } ]
[ { "id": "1.0alpha7.train.30.rel0s1.0alpha7.train.30.ent0_0.o1.0alpha7.train.30.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.30.ent0_0", "arg2_id": "1.0alpha7.train.30.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.30.rel0s1.0alpha7.train.30.ent0_0.o1.0alpha7.train.30.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.30.ent0_0", "arg2_id": "1.0alpha7.train.30.ent4_1", "normalized": [] }, { "id": "1.0alpha7.train.30.rel0s1.0alpha7.train.30.ent1_1.o1.0alpha7.train.30.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.30.ent1_1", "arg2_id": "1.0alpha7.train.30.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.30.rel0s1.0alpha7.train.30.ent1_1.o1.0alpha7.train.30.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.30.ent1_1", "arg2_id": "1.0alpha7.train.30.ent4_1", "normalized": [] } ]
1.0alpha7.train.31
3737303
[ { "id": "1.0alpha7.train.31.sent", "type": "sentence", "text": [ "DNA Binding of Smad5 and Smad4 to the GC-rich Sequence" ], "offsets": [ [ 0, 54 ] ] } ]
[ { "id": "1.0alpha7.train.31.ent0_0", "type": "DNA", "text": [ "GC-rich Sequence" ], "offsets": [ [ 38, 54 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.31.ent1_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.31.ent2_0", "type": "protein", "text": [ "Smad4" ], "offsets": [ [ 25, 30 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4089" }, { "db_name": "hgnc", "db_id": "SMAD4" }, { "db_name": "uniprot", "db_id": "Q13485" } ] }, { "id": "1.0alpha7.train.31.ent3_0", "type": "protein", "text": [ "Smad5" ], "offsets": [ [ 15, 20 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4090" }, { "db_name": "hgnc", "db_id": "SMAD5" }, { "db_name": "uniprot", "db_id": "Q99717" } ] } ]
[]
[ { "id": "1.0alpha7.train.31.coref0", "entity_ids": [ "1.0alpha7.train.31.ent0_0", "1.0alpha7.train.31.ent1_0" ] }, { "id": "1.0alpha7.train.31.coref1", "entity_ids": [ "1.0alpha7.train.31.ent2_0" ] }, { "id": "1.0alpha7.train.31.coref2", "entity_ids": [ "1.0alpha7.train.31.ent3_0" ] } ]
[ { "id": "1.0alpha7.train.31.rel0s1.0alpha7.train.31.ent0_0.o1.0alpha7.train.31.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.31.ent0_0", "arg2_id": "1.0alpha7.train.31.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.31.rel0s1.0alpha7.train.31.ent1_0.o1.0alpha7.train.31.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.31.ent1_0", "arg2_id": "1.0alpha7.train.31.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.31.rel1s1.0alpha7.train.31.ent0_0.o1.0alpha7.train.31.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.31.ent0_0", "arg2_id": "1.0alpha7.train.31.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.31.rel1s1.0alpha7.train.31.ent1_0.o1.0alpha7.train.31.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.31.ent1_0", "arg2_id": "1.0alpha7.train.31.ent3_0", "normalized": [] } ]
1.0alpha7.train.32
3737303
[ { "id": "1.0alpha7.train.32.sent", "type": "sentence", "text": [ "We then examined the direct DNA binding of Smad5 and Smad4 to the GC-rich sequence of PBE." ], "offsets": [ [ 0, 90 ] ] } ]
[ { "id": "1.0alpha7.train.32.ent0_0", "type": "DNA", "text": [ "GC-rich sequence" ], "offsets": [ [ 66, 82 ] ], "normalized": [] }, { "id": "1.0alpha7.train.32.ent1_0", "type": "DNA", "text": [ "PBE" ], "offsets": [ [ 86, 89 ] ], "normalized": [] }, { "id": "1.0alpha7.train.32.ent2_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 28, 31 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.32.ent3_0", "type": "protein", "text": [ "Smad5" ], "offsets": [ [ 43, 48 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4090" }, { "db_name": "hgnc", "db_id": "SMAD5" }, { "db_name": "uniprot", "db_id": "Q99717" } ] }, { "id": "1.0alpha7.train.32.ent4_0", "type": "protein", "text": [ "Smad4" ], "offsets": [ [ 53, 58 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4089" }, { "db_name": "hgnc", "db_id": "SMAD4" }, { "db_name": "uniprot", "db_id": "Q13485" } ] } ]
[]
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1.0alpha7.train.33
11560304
[ { "id": "1.0alpha7.train.33.sent", "type": "sentence", "text": [ "Grundhoff,A.T., Kremmer,E., Tureci,O., Glieden,A., Gindorf,C., Atz,J., Muller-Lantzsch,N., Schubach,W.H. and Grasser,F.A. (1999) Characterisation of DP103, a novel DEAD box protein that binds to the Epstein - Barr virus nuclear proteins EBNA2 and EBNA3C." ], "offsets": [ [ 0, 254 ] ] } ]
[ { "id": "1.0alpha7.train.33.ent0_0", "type": "protein", "text": [ "EBNA2" ], "offsets": [ [ 237, 242 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P12978" } ] }, { "id": "1.0alpha7.train.33.ent1_0", "type": "protein", "text": [ "EBNA3C" ], "offsets": [ [ 247, 253 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "A0A0B6VJ05" } ] }, { "id": "1.0alpha7.train.33.ent2_0", "type": "protein", "text": [ "DP103" ], "offsets": [ [ 149, 154 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "11218" }, { "db_name": "hgnc", "db_id": "DDX20" }, { "db_name": "uniprot", "db_id": "Q9UHI6" } ] }, { "id": "1.0alpha7.train.33.ent3_0", "type": "protein-domain", "text": [ "DEAD box" ], "offsets": [ [ 164, 172 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR011545" } ] }, { "id": "1.0alpha7.train.33.ent4_0", "type": "cell", "text": [ "Epstein - Barr virus" ], "offsets": [ [ 199, 219 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.34
15685147
[ { "id": "1.0alpha7.train.34.sent", "type": "sentence", "text": [ "TPA directly binds PKC, causing an increase in PKC's affinity for calcium and the stimulation of enzymatic activity." ], "offsets": [ [ 0, 116 ] ] } ]
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[]
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1.0alpha7.train.35
24566933
[ { "id": "1.0alpha7.train.35.sent", "type": "sentence", "text": [ "The MKP-3 EB domain binding to ERK2 was not dependent upon ERK2 phosphorylation in our NMR titration experiments, consistent with the previous study of MKP-3 and ERK2 binding with a GST pulldown assay (Camps et al., 1998 )." ], "offsets": [ [ 0, 223 ] ] } ]
[ { "id": "1.0alpha7.train.35.ent0_0", "type": "protein", "text": [ "ERK2" ], "offsets": [ [ 31, 35 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5594" }, { "db_name": "hgnc", "db_id": "MAPK1" }, { "db_name": "uniprot", "db_id": "P28482" } ] }, { "id": "1.0alpha7.train.35.ent1_1", "type": "protein", "text": [ "ERK2" ], "offsets": [ [ 59, 63 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5594" }, { "db_name": "hgnc", "db_id": "MAPK1" }, { "db_name": "uniprot", "db_id": "P28482" } ] }, { "id": "1.0alpha7.train.35.ent2_2", "type": "protein", "text": [ "ERK2" ], "offsets": [ [ 162, 166 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5594" }, { "db_name": "hgnc", "db_id": "MAPK1" }, { "db_name": "uniprot", "db_id": "P28482" } ] }, { "id": "1.0alpha7.train.35.ent3_0", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 182, 185 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.35.ent4_0", "type": "protein", "text": [ "MKP-3" ], "offsets": [ [ 4, 9 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1848" }, { "db_name": "hgnc", "db_id": "DUSP6" }, { "db_name": "uniprot", "db_id": "Q16828" } ] }, { "id": "1.0alpha7.train.35.ent5_1", "type": "protein", "text": [ "MKP-3" ], "offsets": [ [ 152, 157 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1848" }, { "db_name": "hgnc", "db_id": "DUSP6" }, { "db_name": "uniprot", "db_id": "Q16828" } ] }, { "id": "1.0alpha7.train.35.ent6_0", "type": "protein-domain", "text": [ "EB" ], "offsets": [ [ 10, 12 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR006149" } ] } ]
[]
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1.0alpha7.train.36
15862392
[ { "id": "1.0alpha7.train.36.sent", "type": "sentence", "text": [ "Interestingly, the Rb protein binds to TAFII250 at an amino-terminal site which overlaps the NTK domain ( 38)." ], "offsets": [ [ 0, 110 ] ] } ]
[ { "id": "1.0alpha7.train.36.ent0_0", "type": "protein", "text": [ "TAFII250" ], "offsets": [ [ 39, 47 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P51123" } ] }, { "id": "1.0alpha7.train.36.ent1_0", "type": "protein-domain", "text": [ "NTK" ], "offsets": [ [ 93, 96 ] ], "normalized": [] }, { "id": "1.0alpha7.train.36.ent2_0", "type": "protein", "text": [ "Rb" ], "offsets": [ [ 19, 21 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5925" }, { "db_name": "hgnc", "db_id": "RB1" }, { "db_name": "uniprot", "db_id": "P06400" } ] } ]
[]
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1.0alpha7.train.37
3573748
[ { "id": "1.0alpha7.train.37.sent", "type": "sentence", "text": [ "The alpha-helical C terminus of AIP, which is outside the tetratricopeptide repeat domain, is absolutely required for binding to AhR as shown by deletions of the C-terminal 5 amino acids or alanine-scanning mutagenesis, but it is not required for binding of AIP to hsp90." ], "offsets": [ [ 0, 271 ] ] } ]
[ { "id": "1.0alpha7.train.37.ent0_0", "type": "protein", "text": [ "AhR" ], "offsets": [ [ 129, 132 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "196" }, { "db_name": "hgnc", "db_id": "AHR" }, { "db_name": "uniprot", "db_id": "P35869" } ] }, { "id": "1.0alpha7.train.37.ent1_0", "type": "protein-domain", "text": [ "tetratricopeptide repeat domain" ], "offsets": [ [ 58, 89 ] ], "normalized": [] }, { "id": "1.0alpha7.train.37.ent2_0", "type": "protein", "text": [ "hsp90" ], "offsets": [ [ 265, 270 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3320" }, { "db_name": "hgnc", "db_id": "HSP90AA1" }, { "db_name": "uniprot", "db_id": "P07900" } ] }, { "id": "1.0alpha7.train.37.ent3_0", "type": "protein", "text": [ "AIP" ], "offsets": [ [ 32, 35 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9049" }, { "db_name": "hgnc", "db_id": "AIP" }, { "db_name": "uniprot", "db_id": "E9PMH2" } ] }, { "id": "1.0alpha7.train.37.ent4_1", "type": "protein", "text": [ "AIP" ], "offsets": [ [ 258, 261 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9049" }, { "db_name": "hgnc", "db_id": "AIP" }, { "db_name": "uniprot", "db_id": "E9PMH2" } ] } ]
[]
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1.0alpha7.train.38
1380101
[ { "id": "1.0alpha7.train.38.sent", "type": "sentence", "text": [ "Thus, the results of both types of binding assays argue that stable binding of ELL to RNA polymerase II is not sufficient for inhibition of promoter-specific initiation." ], "offsets": [ [ 0, 169 ] ] } ]
[ { "id": "1.0alpha7.train.38.ent0_0", "type": "protein-complex", "text": [ "RNA polymerase II" ], "offsets": [ [ 86, 103 ] ], "normalized": [] }, { "id": "1.0alpha7.train.38.ent1_0", "type": "protein-family", "text": [ "ELL" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR031176" } ] } ]
[]
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1.0alpha7.train.39
2712406
[ { "id": "1.0alpha7.train.39.sent", "type": "sentence", "text": [ " Growth arrest by TGF-beta is dependent on Rb and interfered with by direct binding of E1A to Rb ( 33, 34, 37). " ], "offsets": [ [ 0, 119 ] ] } ]
[ { "id": "1.0alpha7.train.39.ent0_0", "type": "protein", "text": [ "E1A" ], "offsets": [ [ 90, 93 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P03255" } ] }, { "id": "1.0alpha7.train.39.ent1_0", "type": "protein", "text": [ "Rb" ], "offsets": [ [ 45, 47 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5925" }, { "db_name": "hgnc", "db_id": "RB1" }, { "db_name": "uniprot", "db_id": "P06400" } ] }, { "id": "1.0alpha7.train.39.ent2_1", "type": "protein", "text": [ "Rb" ], "offsets": [ [ 98, 100 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5925" }, { "db_name": "hgnc", "db_id": "RB1" }, { "db_name": "uniprot", "db_id": "P06400" } ] }, { "id": "1.0alpha7.train.39.ent3_0", "type": "protein", "text": [ "TGF-beta" ], "offsets": [ [ 19, 27 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7040" }, { "db_name": "hgnc", "db_id": "TGFB1" }, { "db_name": "uniprot", "db_id": "NA" } ] } ]
[]
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1.0alpha7.train.40
2528920
[ { "id": "1.0alpha7.train.40.sent", "type": "sentence", "text": [ "In an effort to identify the PG that binds to IFN-gamma, we performed Western blot analysis. " ], "offsets": [ [ 0, 96 ] ] } ]
[ { "id": "1.0alpha7.train.40.ent0_0", "type": "protein", "text": [ "IFN-gamma" ], "offsets": [ [ 48, 57 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3458" }, { "db_name": "hgnc", "db_id": "IFNG" }, { "db_name": "uniprot", "db_id": "P01579" } ] }, { "id": "1.0alpha7.train.40.ent1_0", "type": "chemical", "text": [ "PG" ], "offsets": [ [ 30, 32 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "52927148" } ] } ]
[]
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1.0alpha7.train.41
15213790
[ { "id": "1.0alpha7.train.41.sent", "type": "sentence", "text": [ "Both E1A and PU.1 bind to the CH3 domain of CBP but require additional contacts for full CBP inhibition." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
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1.0alpha7.train.42
15178756
[ { "id": "1.0alpha7.train.42.sent", "type": "sentence", "text": [ "SAF-A interacts with S/MARs via its N-terminal SAF box ( 36) and via its C-terminal domain with p300, allowing binding of SAF-A to both p300 and a S/MAR element." ], "offsets": [ [ 0, 161 ] ] } ]
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[]
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[]
1.0alpha7.train.43
1989374
[ { "id": "1.0alpha7.train.43.sent", "type": "sentence", "text": [ "Interestingly, both Oct-1 and Pbx binding to the PRL3 nGRE were found to be required for glucocorticoid repression." ], "offsets": [ [ 0, 115 ] ] } ]
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[]
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1.0alpha7.train.44
22546615
[ { "id": "1.0alpha7.train.44.sent", "type": "sentence", "text": [ "It is also noteworthy that other CC chemokines, such as MDC (binds CCR4) and the recently identified putative chemokine receptor TYMSTR (ligand unknown) [40], can inhibit HIV-1 infection of T lymphocytes, whereas I-309 (binds CCR8) inhibits CCR8-dependent infection of monocytes by diverse HIV-1 strains, further suggesting that a number of chemokine receptors are involved in HIV-1 entry [64,106]." ], "offsets": [ [ 0, 398 ] ] } ]
[ { "id": "1.0alpha7.train.44.ent0_0", "type": "protein", "text": [ "MDC" ], "offsets": [ [ 56, 59 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6367" }, { "db_name": "hgnc", "db_id": "CCL22" }, { "db_name": "uniprot", "db_id": "O00626" } ] }, { "id": "1.0alpha7.train.44.ent1_0", "type": "protein-family", "text": [ "CC chemokines" ], "offsets": [ [ 33, 46 ] ], "normalized": [] }, { "id": "1.0alpha7.train.44.ent2_0", "type": "cell", "text": [ "HIV-1" ], "offsets": [ [ 171, 176 ] ], "normalized": [] }, { "id": "1.0alpha7.train.44.ent3_1", "type": "cell", "text": [ "HIV-1" ], "offsets": [ [ 290, 295 ] ], "normalized": [] }, { "id": "1.0alpha7.train.44.ent4_2", "type": "cell", "text": [ "HIV-1" ], "offsets": [ [ 377, 382 ] ], "normalized": [] }, { "id": "1.0alpha7.train.44.ent5_0", "type": "protein", "text": [ "CCR4" ], "offsets": [ [ 67, 71 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1233" }, { "db_name": "hgnc", "db_id": "CCR4" }, { "db_name": "uniprot", "db_id": "P51679" } ] }, { "id": "1.0alpha7.train.44.ent6_0", "type": "protein", "text": [ "I-309" ], "offsets": [ [ 213, 218 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6346" }, { "db_name": "hgnc", "db_id": "CCL1" }, { "db_name": "uniprot", "db_id": "P22362" } ] }, { "id": "1.0alpha7.train.44.ent7_0", "type": "protein", "text": [ "CCR8" ], "offsets": [ [ 226, 230 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1237" }, { "db_name": "hgnc", "db_id": "CCR8" } ] }, { "id": "1.0alpha7.train.44.ent8_1", "type": "protein", "text": [ "CCR8" ], "offsets": [ [ 241, 245 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1237" }, { "db_name": "hgnc", "db_id": "CCR8" } ] } ]
[]
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1.0alpha7.train.45
6981221
[ { "id": "1.0alpha7.train.45.sent", "type": "sentence", "text": [ "All the mixtures tested exhibited equal amounts of REGs α and β bound to the proteasome at both concentrations confirming the higher affinity of α/β heterooligomers for the proteasome as reported in ref. 14." ], "offsets": [ [ 0, 207 ] ] } ]
[ { "id": "1.0alpha7.train.45.ent0_0", "type": "protein", "text": [ "α" ], "offsets": [ [ 56, 57 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5967" }, { "db_name": "hgnc", "db_id": "REG1A" }, { "db_name": "uniprot", "db_id": "P05451" } ] }, { "id": "1.0alpha7.train.45.ent1_1", "type": "protein", "text": [ "α" ], "offsets": [ [ 145, 146 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5967" }, { "db_name": "hgnc", "db_id": "REG1A" }, { "db_name": "uniprot", "db_id": "P05451" } ] }, { "id": "1.0alpha7.train.45.ent2_0", "type": "protein", "text": [ "REGs α" ], "offsets": [ [ 51, 57 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5967" }, { "db_name": "hgnc", "db_id": "REG1A" }, { "db_name": "uniprot", "db_id": "P05451" } ] }, { "id": "1.0alpha7.train.45.ent3_0", "type": "protein-complex", "text": [ "proteasome" ], "offsets": [ [ 77, 87 ] ], "normalized": [] }, { "id": "1.0alpha7.train.45.ent4_1", "type": "protein-complex", "text": [ "proteasome" ], "offsets": [ [ 173, 183 ] ], "normalized": [] }, { "id": "1.0alpha7.train.45.ent5_0", "type": "protein", "text": [ "β" ], "offsets": [ [ 62, 63 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5968" }, { "db_name": "hgnc", "db_id": "REG1B" }, { "db_name": "uniprot", "db_id": "P48304" } ] }, { "id": "1.0alpha7.train.45.ent6_1", "type": "protein", "text": [ "β" ], "offsets": [ [ 147, 148 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5968" }, { "db_name": "hgnc", "db_id": "REG1B" }, { "db_name": "uniprot", "db_id": "P48304" } ] }, { "id": "1.0alpha7.train.45.ent7_0", "type": "protein-complex", "text": [ "α/β heterooligomers" ], "offsets": [ [ 145, 164 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.46
12893060
[ { "id": "1.0alpha7.train.46.sent", "type": "sentence", "text": [ "CHRIVIA, J. C., R. P. KWOK, N. LAMB, M. HAGIWARA, and M. R. MONTMINY et al., 1993 Phosphorylated CREB binds specifically to the nuclear protein CBP." ], "offsets": [ [ 0, 148 ] ] } ]
[ { "id": "1.0alpha7.train.46.ent0_0", "type": "protein", "text": [ "CREB" ], "offsets": [ [ 97, 101 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1385" }, { "db_name": "hgnc", "db_id": "CREB1" }, { "db_name": "uniprot", "db_id": "P16220" } ] }, { "id": "1.0alpha7.train.46.ent1_0", "type": "protein", "text": [ "Phosphorylated CREB" ], "offsets": [ [ 82, 101 ] ], "normalized": [] }, { "id": "1.0alpha7.train.46.ent2_0", "type": "protein", "text": [ "CBP" ], "offsets": [ [ 144, 147 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1387" }, { "db_name": "hgnc", "db_id": "CREBBP" }, { "db_name": "uniprot", "db_id": "Q92793" } ] } ]
[]
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1.0alpha7.train.47
5336461
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1.0alpha7.train.48
18184622
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1.0alpha7.train.49
16888707
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1.0alpha7.train.50
19537787
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1.0alpha7.train.51
20533795
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1.0alpha7.train.52
5881211
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1.0alpha7.train.53
1070296
[ { "id": "1.0alpha7.train.53.sent", "type": "sentence", "text": [ "Controls consisted of 1) phosphorylation mix (containing only buffer and ATP), 2) phosphorylation mix containing unphosphorylated peIF-2, 3) phosphorylation mix containing unphosphorylated meIF-2, and 4) phosphorylation mix alone incubated previously with mPKR bound to poly(rI) poly(rC)-agarose." ], "offsets": [ [ 0, 296 ] ] } ]
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[]
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1.0alpha7.train.54
665872
[ { "id": "1.0alpha7.train.54.sent", "type": "sentence", "text": [ "p75 TNFR binds TNF-alpha with a higher affinity and with a higher dissociation rate than p55 TNFR ( K d of 100 pM versus 500 pM and t1/2 of 10 min versus 3 h) ( 15)." ], "offsets": [ [ 0, 165 ] ] } ]
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[]
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1.0alpha7.train.55
15841843
[ { "id": "1.0alpha7.train.55.sent", "type": "sentence", "text": [ "This analysis demonstrated that JIP2 binds to JNK, MKK7, and MLK3 (Fig. 5)." ], "offsets": [ [ 0, 75 ] ] } ]
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[]
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1.0alpha7.train.56
18031606
[ { "id": "1.0alpha7.train.56.sent", "type": "sentence", "text": [ "Generally, binding of importin-α to the NLS involves two sites within the import receptor molecule, a major site spanning the amino-terminal end of the receptor between the first and fourth arm repeats and a minor site located at the carboxy-terminus between arm repeats 4 and 8 (Conti and Kuriyan, 2000; Fontes et al., 2000)." ], "offsets": [ [ 0, 326 ] ] } ]
[ { "id": "1.0alpha7.train.56.ent0_0", "type": "protein-motif", "text": [ "NLS" ], "offsets": [ [ 40, 43 ] ], "normalized": [] }, { "id": "1.0alpha7.train.56.ent1_0", "type": "protein-family", "text": [ "importin-α" ], "offsets": [ [ 22, 32 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR024931" } ] } ]
[]
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1.0alpha7.train.57
11310367
[ { "id": "1.0alpha7.train.57.sent", "type": "sentence", "text": [ "The incomplete WT p50csk inhibition of FN-stimulated signaling events in the FAK1 cells is consistent with studies performed in NIH 3T3 fibroblasts where direct FN-stimulated FAK-mediated phosphorylation of Shc can promote Grb2 binding and signaling to ERK2 under conditions of inhibited Src PTK activity (Schlaepfer et al., 1998)." ], "offsets": [ [ 0, 331 ] ] } ]
[ { "id": "1.0alpha7.train.57.ent0_0", "type": "protein", "text": [ "ERK2" ], "offsets": [ [ 253, 257 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5594" }, { "db_name": "hgnc", "db_id": "MAPK1" }, { "db_name": "uniprot", "db_id": "P28482" } ] }, { "id": "1.0alpha7.train.57.ent1_0", "type": "protein", "text": [ "Grb2" ], "offsets": [ [ 223, 227 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2885" }, { "db_name": "hgnc", "db_id": "GRB2" }, { "db_name": "uniprot", "db_id": "P62993" } ] }, { "id": "1.0alpha7.train.57.ent2_0", "type": "protein", "text": [ "FAK" ], "offsets": [ [ 175, 178 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5747" }, { "db_name": "hgnc", "db_id": "PTK2" }, { "db_name": "uniprot", "db_id": "Q05397" } ] }, { "id": "1.0alpha7.train.57.ent3_0", "type": "protein", "text": [ "Shc" ], "offsets": [ [ 207, 210 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6464" }, { "db_name": "hgnc", "db_id": "SHC1" }, { "db_name": "uniprot", "db_id": "P29353" } ] }, { "id": "1.0alpha7.train.57.ent4_0", "type": "protein", "text": [ "p50csk" ], "offsets": [ [ 18, 24 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1445" }, { "db_name": "hgnc", "db_id": "CSK" }, { "db_name": "uniprot", "db_id": "P41240" } ] }, { "id": "1.0alpha7.train.57.ent5_0", "type": "cell", "text": [ "NIH 3T3" ], "offsets": [ [ 128, 135 ] ], "normalized": [] }, { "id": "1.0alpha7.train.57.ent6_0", "type": "protein", "text": [ "WT p50csk" ], "offsets": [ [ 15, 24 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.58
7097765
[ { "id": "1.0alpha7.train.58.sent", "type": "sentence", "text": [ "Indirect evidence that the UBC9 homolog from higher eukaryotes is a SUMO-1-conjugating enzyme came from recent reports, demonstrating physical interactions of UBC9 with SUMO-1 (11) and RanBP2, the nuclear pore complex protein bound by SUMO-1 conjugated RanGAP1 (28)." ], "offsets": [ [ 0, 266 ] ] } ]
[ { "id": "1.0alpha7.train.58.ent0_0", "type": "protein", "text": [ "UBC9" ], "offsets": [ [ 27, 31 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7329" }, { "db_name": "hgnc", "db_id": "UBE2I" }, { "db_name": "uniprot", "db_id": "P63279" } ] }, { "id": "1.0alpha7.train.58.ent1_1", "type": "protein", "text": [ "UBC9" ], "offsets": [ [ 159, 163 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7329" }, { "db_name": "hgnc", "db_id": "UBE2I" }, { "db_name": "uniprot", "db_id": "P63279" } ] }, { "id": "1.0alpha7.train.58.ent2_0", "type": "protein", "text": [ "SUMO-1" ], "offsets": [ [ 68, 74 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7341" }, { "db_name": "hgnc", "db_id": "SUMO1" }, { "db_name": "uniprot", "db_id": "P63165" } ] }, { "id": "1.0alpha7.train.58.ent3_1", "type": "protein", "text": [ "SUMO-1" ], "offsets": [ [ 169, 175 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7341" }, { "db_name": "hgnc", "db_id": "SUMO1" }, { "db_name": "uniprot", "db_id": "P63165" } ] }, { "id": "1.0alpha7.train.58.ent4_2", "type": "protein", "text": [ "SUMO-1" ], "offsets": [ [ 235, 241 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7341" }, { "db_name": "hgnc", "db_id": "SUMO1" }, { "db_name": "uniprot", "db_id": "P63165" } ] }, { "id": "1.0alpha7.train.58.ent5_0", "type": "protein", "text": [ "RanGAP1" ], "offsets": [ [ 253, 260 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5905" }, { "db_name": "hgnc", "db_id": "RANGAP1" }, { "db_name": "uniprot", "db_id": "P46060" } ] }, { "id": "1.0alpha7.train.58.ent6_0", "type": "protein", "text": [ "RanBP2" ], "offsets": [ [ 185, 191 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5903" }, { "db_name": "hgnc", "db_id": "RANBP2" }, { "db_name": "uniprot", "db_id": "P49792" } ] } ]
[]
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1.0alpha7.train.59
9539475
[ { "id": "1.0alpha7.train.59.sent", "type": "sentence", "text": [ "Paxillin failed to bind GST alone or the SH2 domain of Grb2 that belongs to the family of SH2/SH3-containing signaling molecules." ], "offsets": [ [ 0, 129 ] ] } ]
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[]
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1.0alpha7.train.60
15386609
[ { "id": "1.0alpha7.train.60.sent", "type": "sentence", "text": [ "E2Fs bind directly to Rb, p107, and p130, and we have previously shown that these proteins are components of the transcription complexes formed on E2F target promoters in vivo ( 49)." ], "offsets": [ [ 0, 182 ] ] } ]
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[]
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1.0alpha7.train.61
9369450
[ { "id": "1.0alpha7.train.61.sent", "type": "sentence", "text": [ "AAK1 localizes to regions active in endocytosis AAK1 binds directly to AP2." ], "offsets": [ [ 0, 75 ] ] } ]
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[]
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1.0alpha7.train.62
2498077
[ { "id": "1.0alpha7.train.62.sent", "type": "sentence", "text": [ "Both these regions of p300/CBP bind to the transactivation domain of Ets-2, whereas the C-terminal region binds only to the DNA binding domain of Ets-2." ], "offsets": [ [ 0, 152 ] ] } ]
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[]
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1.0alpha7.train.63
17880851
[ { "id": "1.0alpha7.train.63.sent", "type": "sentence", "text": [ "The major head protein of bacteriophage T4 binds specifically to elongation factor Tu." ], "offsets": [ [ 0, 86 ] ] } ]
[ { "id": "1.0alpha7.train.63.ent0_0", "type": "protein-family", "text": [ "elongation factor Tu" ], "offsets": [ [ 65, 85 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR004541" } ] }, { "id": "1.0alpha7.train.63.ent1_0", "type": "cell", "text": [ "T4" ], "offsets": [ [ 40, 42 ] ], "normalized": [] }, { "id": "1.0alpha7.train.63.ent2_0", "type": "protein", "text": [ "major head protein" ], "offsets": [ [ 4, 22 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P04535" } ] } ]
[]
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1.0alpha7.train.64
13063305
[ { "id": "1.0alpha7.train.64.sent", "type": "sentence", "text": [ "This Psc binding might potentiate the action of a weak Pc- and Ph-binding PRE present in the bxd-Ubx-lacZ vector." ], "offsets": [ [ 0, 118 ] ] } ]
[ { "id": "1.0alpha7.train.64.ent0_0", "type": "protein", "text": [ "Psc" ], "offsets": [ [ 6, 9 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "D0Z760" } ] }, { "id": "1.0alpha7.train.64.ent1_0", "type": "experimental-construct", "text": [ "bxd-Ubx-lacZ" ], "offsets": [ [ 98, 110 ] ], "normalized": [] }, { "id": "1.0alpha7.train.64.ent2_0", "type": "DNA", "text": [ "Ph-binding PRE" ], "offsets": [ [ 66, 80 ] ], "normalized": [] }, { "id": "1.0alpha7.train.64.ent3_0", "type": "DNA", "text": [ "Pc-" ], "offsets": [ [ 57, 60 ] ], "normalized": [] } ]
[]
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[]
1.0alpha7.train.65
20508399
[ { "id": "1.0alpha7.train.65.sent", "type": "sentence", "text": [ "The ability to form H-DNA cannot substitute for GAGA factor binding to the ( CT)n sequence." ], "offsets": [ [ 0, 91 ] ] } ]
[ { "id": "1.0alpha7.train.65.ent0_0", "type": "DNA", "text": [ "H-DNA" ], "offsets": [ [ 20, 25 ] ], "normalized": [] }, { "id": "1.0alpha7.train.65.ent1_0", "type": "protein", "text": [ "GAGA factor" ], "offsets": [ [ 48, 59 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q08605" } ] }, { "id": "1.0alpha7.train.65.ent2_0", "type": "DNA", "text": [ "( CT)n" ], "offsets": [ [ 75, 81 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.66
11328273
[ { "id": "1.0alpha7.train.66.sent", "type": "sentence", "text": [ "We predict that these PH domains will also bind PI3K products with high affinity, but this has not yet been tested or was inconclusive." ], "offsets": [ [ 0, 135 ] ] } ]
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[]
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[]
1.0alpha7.train.67
6370284
[ { "id": "1.0alpha7.train.67.sent", "type": "sentence", "text": [ "This defect in the activity of eIF5B in the presence of GMP-PNP could be because hydrolysis of GTP bound to eIF5B is required for the release of eIF5B from assembled 80S ribosomes, for the release of other factors, or for both." ], "offsets": [ [ 0, 227 ] ] } ]
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[]
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1.0alpha7.train.68
19665905
[ { "id": "1.0alpha7.train.68.sent", "type": "sentence", "text": [ "The accumulation of DephrindeltaC-term around axons suggests that Dephrin may bind to DEph." ], "offsets": [ [ 0, 91 ] ] } ]
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[]
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1.0alpha7.train.69
10601863
[ { "id": "1.0alpha7.train.69.sent", "type": "sentence", "text": [ "Characterization of substance P binding to human monocytes/macrophages." ], "offsets": [ [ 0, 71 ] ] } ]
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[]
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[]
1.0alpha7.train.70
3475884
[ { "id": "1.0alpha7.train.70.sent", "type": "sentence", "text": [ "Karyopherin beta2 (Kapbeta2, transportin) binds the M9 sequence of human ribonucleoprotein A1 and mediates its nuclear import." ], "offsets": [ [ 0, 126 ] ] } ]
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[]
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1.0alpha7.train.71
5626303
[ { "id": "1.0alpha7.train.71.sent", "type": "sentence", "text": [ "Some E2F may remain bound to a partially phosphorylated Rb throughout the normal cell cycle." ], "offsets": [ [ 0, 92 ] ] } ]
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[]
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1.0alpha7.train.72
12634030
[ { "id": "1.0alpha7.train.72.sent", "type": "sentence", "text": [ "On the basis of these observations and our demonstration of direct binding of Cdc6p to ORC on origin DNA, we suggest that it is in this complex that Cdc6p recruits the MCM proteins." ], "offsets": [ [ 0, 181 ] ] } ]
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[]
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1.0alpha7.train.73
3367578
[ { "id": "1.0alpha7.train.73.sent", "type": "sentence", "text": [ "Competition and co-immunoprecipitation experiments demonstrated that the binding of TnT to Tm was cooperative in the absence of F-actin." ], "offsets": [ [ 0, 136 ] ] } ]
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[]
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1.0alpha7.train.74
23084493
[ { "id": "1.0alpha7.train.74.sent", "type": "sentence", "text": [ "Amagai M, Karpati S, Prussick R, Klaus-Kovtun V, Stanley JR (1992) Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic." ], "offsets": [ [ 0, 183 ] ] } ]
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[]
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[]
1.0alpha7.train.75
24177
[ { "id": "1.0alpha7.train.75.sent", "type": "sentence", "text": [ "Inhibin also binds to ActRII through its beta subunit, competes with the binding of activin to ActRII, but fails to form the ActRII SKR2 complex." ], "offsets": [ [ 0, 145 ] ] } ]
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[]
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1.0alpha7.train.76
22450950
[ { "id": "1.0alpha7.train.76.sent", "type": "sentence", "text": [ "These results demonstrate that Sp1 and Sp3 can both bind to the Sp1 consensus sequence in the IGF-II promoter." ], "offsets": [ [ 0, 110 ] ] } ]
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[]
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1.0alpha7.train.77
15810883
[ { "id": "1.0alpha7.train.77.sent", "type": "sentence", "text": [ "Recently, U2AF35 has been shown to be able to directly assist U2AF65 binding to Py tracts ( 25)." ], "offsets": [ [ 0, 96 ] ] } ]
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[]
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1.0alpha7.train.78
1778453
[ { "id": "1.0alpha7.train.78.sent", "type": "sentence", "text": [ "Characterization of IP4 binding to GST-STII-C2B and GST-STIII-C2Bα-loopβ7-8." ], "offsets": [ [ 0, 76 ] ] } ]
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[]
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[]
1.0alpha7.train.79
15268259
[ { "id": "1.0alpha7.train.79.sent", "type": "sentence", "text": [ "Experimental studies of liver regeneration, the acute-phase response to inflammation, and the pathology of myotonic dystrophy (DM) showed that, in all of these situations, CUGBP1 binds to the GCN repeats within the 5′ region of C/EBPβ mRNA and induces downstream translation initiation of a dominant-negative C/EBPβ isoform, LIP (30, 33, 36)." ], "offsets": [ [ 0, 342 ] ] } ]
[ { "id": "1.0alpha7.train.79.ent0_0", "type": "protein", "text": [ "C/EBPβ" ], "offsets": [ [ 228, 234 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1051" }, { "db_name": "hgnc", "db_id": "CEBPB" }, { "db_name": "uniprot", "db_id": "P17676" } ] }, { "id": "1.0alpha7.train.79.ent1_1", "type": "protein", "text": [ "C/EBPβ" ], "offsets": [ [ 309, 315 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1051" }, { "db_name": "hgnc", "db_id": "CEBPB" }, { "db_name": "uniprot", "db_id": "P17676" } ] }, { "id": "1.0alpha7.train.79.ent2_0", "type": "protein-isoform", "text": [ "LIP" ], "offsets": [ [ 325, 328 ] ], "normalized": [] }, { "id": "1.0alpha7.train.79.ent3_0", "type": "protein", "text": [ "CUGBP1" ], "offsets": [ [ 172, 178 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "10658" }, { "db_name": "hgnc", "db_id": "CELF1" }, { "db_name": "uniprot", "db_id": "Q92879" } ] }, { "id": "1.0alpha7.train.79.ent4_0", "type": "RNA", "text": [ "C/EBPβ mRNA" ], "offsets": [ [ 228, 239 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1051" }, { "db_name": "hgnc", "db_id": "CEBPB" }, { "db_name": "uniprot", "db_id": "P17676" } ] }, { "id": "1.0alpha7.train.79.ent5_0", "type": "DNA", "text": [ "GCN repeats" ], "offsets": [ [ 192, 203 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.80
4598555
[ { "id": "1.0alpha7.train.80.sent", "type": "sentence", "text": [ "We have found that full-length recombinant yeast TAF130p does not form a stable ternary complex with yeast TBP bound to TATA DNA and consequently does not actively dissociate the TBP-DNA complex; rather, full-length TAF130p binds to TBP competitively with respect to DNA." ], "offsets": [ [ 0, 271 ] ] } ]
[ { "id": "1.0alpha7.train.80.ent0_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 125, 128 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.80.ent1_1", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 183, 186 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.80.ent2_2", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 267, 270 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.80.ent3_0", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 107, 110 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.80.ent4_1", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 179, 182 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.80.ent5_2", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 233, 236 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.80.ent6_0", "type": "protein", "text": [ "TAF130p" ], "offsets": [ [ 49, 56 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P46677" } ] }, { "id": "1.0alpha7.train.80.ent7_1", "type": "protein", "text": [ "TAF130p" ], "offsets": [ [ 216, 223 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P46677" } ] }, { "id": "1.0alpha7.train.80.ent8_0", "type": "DNA", "text": [ "TATA" ], "offsets": [ [ 120, 124 ] ], "normalized": [] }, { "id": "1.0alpha7.train.80.ent9_0", "type": "protein-complex", "text": [ "TBP-DNA" ], "offsets": [ [ 179, 186 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.81
11949602
[ { "id": "1.0alpha7.train.81.sent", "type": "sentence", "text": [ "In summary, the Dfd homeodomain binds to Exd in vitro, but the Dfd activation domain does not interact in vitro with either the Dfd homeodomain or Exd." ], "offsets": [ [ 0, 151 ] ] } ]
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[]
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1.0alpha7.train.82
5002246
[ { "id": "1.0alpha7.train.82.sent", "type": "sentence", "text": [ "D, Scatchard plots for TNP-ATP binding to MBP 6.2Cdelta36 at pH of 7.5 ( squares) and 6.5 ( diamonds)." ], "offsets": [ [ 0, 102 ] ] } ]
[ { "id": "1.0alpha7.train.82.ent0_0", "type": "protein", "text": [ "MBP 6.2Cdelta36" ], "offsets": [ [ 42, 57 ] ], "normalized": [] }, { "id": "1.0alpha7.train.82.ent1_0", "type": "protein", "text": [ "MBP" ], "offsets": [ [ 42, 45 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4153" }, { "db_name": "hgnc", "db_id": "MBL2" }, { "db_name": "uniprot", "db_id": "P11226" } ] }, { "id": "1.0alpha7.train.82.ent2_0", "type": "chemical", "text": [ "TNP-ATP" ], "offsets": [ [ 23, 30 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "644357" } ] } ]
[]
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1.0alpha7.train.83
8934428
[ { "id": "1.0alpha7.train.83.sent", "type": "sentence", "text": [ "The finding that Plexins can bind Semaphorins, combined with previous studies showing that Plexins can bind Plexins (Ohta et al. 1995), raises questions of whether some Semaphorins might bind one another and whether class I Semaphorins might also function as receptors." ], "offsets": [ [ 0, 269 ] ] } ]
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[]
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"bind", "arg1_id": "1.0alpha7.train.83.ent4_1", "arg2_id": "1.0alpha7.train.83.ent5_2", "normalized": [] }, { "id": "1.0alpha7.train.83.rel1s1.0alpha7.train.83.ent5_2.o1.0alpha7.train.83.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent5_2", "arg2_id": "1.0alpha7.train.83.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.83.rel1s1.0alpha7.train.83.ent5_2.o1.0alpha7.train.83.ent4_1", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent5_2", "arg2_id": "1.0alpha7.train.83.ent4_1", "normalized": [] }, { "id": "1.0alpha7.train.83.rel1s1.0alpha7.train.83.ent5_2.o1.0alpha7.train.83.ent5_2", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent5_2", "arg2_id": "1.0alpha7.train.83.ent5_2", "normalized": [] }, { "id": "1.0alpha7.train.83.rel2s1.0alpha7.train.83.ent0_0.o1.0alpha7.train.83.ent0_0", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent0_0", "arg2_id": "1.0alpha7.train.83.ent0_0", "normalized": [] }, { "id": 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"normalized": [] }, { "id": "1.0alpha7.train.83.rel2s1.0alpha7.train.83.ent2_2.o1.0alpha7.train.83.ent0_0", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent2_2", "arg2_id": "1.0alpha7.train.83.ent0_0", "normalized": [] }, { "id": "1.0alpha7.train.83.rel2s1.0alpha7.train.83.ent2_2.o1.0alpha7.train.83.ent1_1", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent2_2", "arg2_id": "1.0alpha7.train.83.ent1_1", "normalized": [] }, { "id": "1.0alpha7.train.83.rel2s1.0alpha7.train.83.ent2_2.o1.0alpha7.train.83.ent2_2", "type": "bind", "arg1_id": "1.0alpha7.train.83.ent2_2", "arg2_id": "1.0alpha7.train.83.ent2_2", "normalized": [] } ]
1.0alpha7.train.84
9849106
[ { "id": "1.0alpha7.train.84.sent", "type": "sentence", "text": [ "To test whether p97 binds phosphorylated p47, p97 and p47 were incubated in the presence of Cdc2 and [gamma-32] ATP ( Fig. 3 A)." ], "offsets": [ [ 0, 128 ] ] } ]
[ { "id": "1.0alpha7.train.84.ent0_0", "type": "protein", "text": [ "p47" ], "offsets": [ [ 41, 44 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55968" }, { "db_name": "hgnc", "db_id": "NSFL1C" }, { "db_name": "uniprot", "db_id": "Q9UNZ2" } ] }, { "id": "1.0alpha7.train.84.ent1_1", "type": "protein", "text": [ "p47" ], "offsets": [ [ 54, 57 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "55968" }, { "db_name": "hgnc", "db_id": "NSFL1C" }, { "db_name": "uniprot", "db_id": "Q9UNZ2" } ] }, { "id": "1.0alpha7.train.84.ent2_0", "type": "protein", "text": [ "Cdc2" ], "offsets": [ [ 92, 96 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "983" }, { "db_name": "hgnc", "db_id": "CDK1" }, { "db_name": "uniprot", "db_id": "P06493" } ] }, { "id": "1.0alpha7.train.84.ent3_0", "type": "protein", "text": [ "phosphorylated p47" ], "offsets": [ [ 26, 44 ] ], "normalized": [] }, { "id": "1.0alpha7.train.84.ent4_0", "type": "chemical", "text": [ "ATP" ], "offsets": [ [ 112, 115 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5957" } ] }, { "id": "1.0alpha7.train.84.ent5_0", "type": "protein", "text": [ "p97" ], "offsets": [ [ 16, 19 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7415" }, { "db_name": "hgnc", "db_id": "VCP" }, { "db_name": "uniprot", "db_id": "P55072" } ] }, { "id": "1.0alpha7.train.84.ent6_1", "type": "protein", "text": [ "p97" ], "offsets": [ [ 46, 49 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "7415" }, { "db_name": "hgnc", "db_id": "VCP" }, { "db_name": "uniprot", "db_id": "P55072" } ] } ]
[]
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1.0alpha7.train.85
2164892
[ { "id": "1.0alpha7.train.85.sent", "type": "sentence", "text": [ "In contrast, the binding of Diva to Apaf-1 was not significantly affected by Bcl-XL (Fig. 8 A)." ], "offsets": [ [ 0, 95 ] ] } ]
[ { "id": "1.0alpha7.train.85.ent0_0", "type": "protein", "text": [ "Apaf-1" ], "offsets": [ [ 36, 42 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "317" }, { "db_name": "hgnc", "db_id": "APAF1" }, { "db_name": "uniprot", "db_id": "O14727" } ] }, { "id": "1.0alpha7.train.85.ent1_0", "type": "protein", "text": [ "Bcl-XL" ], "offsets": [ [ 77, 83 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "598" }, { "db_name": "hgnc", "db_id": "BCL2L1" }, { "db_name": "uniprot", "db_id": "Q07817" } ] }, { "id": "1.0alpha7.train.85.ent2_0", "type": "protein", "text": [ "Diva" ], "offsets": [ [ 28, 32 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "10017" }, { "db_name": "hgnc", "db_id": "BCL2L10" }, { "db_name": "uniprot", "db_id": "H0YMD5" } ] } ]
[]
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1.0alpha7.train.86
3548985
[ { "id": "1.0alpha7.train.86.sent", "type": "sentence", "text": [ "Triton X-100 extracts from a crude rat brain nuclear fraction was incubated with GST or GST-GBR1, and protein binding to the fusion proteins was recovered by adding glutathione beads." ], "offsets": [ [ 0, 183 ] ] } ]
[ { "id": "1.0alpha7.train.86.ent0_0", "type": "chemical", "text": [ "Triton X-100" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5590" } ] }, { "id": "1.0alpha7.train.86.ent1_0", "type": "protein", "text": [ "GBR1" ], "offsets": [ [ 92, 96 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2550" }, { "db_name": "hgnc", "db_id": "GABBR1" }, { "db_name": "uniprot", "db_id": "Q9UBS5" } ] }, { "id": "1.0alpha7.train.86.ent2_0", "type": "experimental-construct", "text": [ "GST-GBR1" ], "offsets": [ [ 88, 96 ] ], "normalized": [] }, { "id": "1.0alpha7.train.86.ent3_0", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 81, 84 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.86.ent4_1", "type": "experiment-tag", "text": [ "GST" ], "offsets": [ [ 88, 91 ] ], "normalized": [ { "db_name": "intenz", "db_id": "2.5.1.18" } ] }, { "id": "1.0alpha7.train.86.ent5_0", "type": "chemical", "text": [ "glutathione" ], "offsets": [ [ 165, 176 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "124886" } ] } ]
[]
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[]
1.0alpha7.train.87
11828384
[ { "id": "1.0alpha7.train.87.sent", "type": "sentence", "text": [ "It is noteworthy that GSK-3beta bound to beta-catenin only when FWD1 was co-transfected (Figure 3A, lane 2)." ], "offsets": [ [ 0, 108 ] ] } ]
[ { "id": "1.0alpha7.train.87.ent0_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 41, 53 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.87.ent1_0", "type": "protein", "text": [ "GSK-3beta" ], "offsets": [ [ 22, 31 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2932" }, { "db_name": "hgnc", "db_id": "GSK3B" }, { "db_name": "uniprot", "db_id": "P49841" } ] }, { "id": "1.0alpha7.train.87.ent2_0", "type": "protein", "text": [ "FWD1" ], "offsets": [ [ 64, 68 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8945" }, { "db_name": "hgnc", "db_id": "BTRC" }, { "db_name": "uniprot", "db_id": "Q9Y297" } ] } ]
[]
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1.0alpha7.train.88
2450060
[ { "id": "1.0alpha7.train.88.sent", "type": "sentence", "text": [ "A mutant form of Pyk2 (Pyk2-Y402F) that is unable to bind and activate Src is impaired in its ability to induce association of Grb2 with Shc, binding of Crk to p130Cas and stimulation of the ERK and JNK cascades." ], "offsets": [ [ 0, 212 ] ] } ]
[ { "id": "1.0alpha7.train.88.ent0_0", "type": "protein", "text": [ "Src" ], "offsets": [ [ 71, 74 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6714" }, { "db_name": "hgnc", "db_id": "SRC" }, { "db_name": "uniprot", "db_id": "P12931" } ] }, { "id": "1.0alpha7.train.88.ent1_0", "type": "protein", "text": [ "Pyk2" ], "offsets": [ [ 17, 21 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2185" }, { "db_name": "hgnc", "db_id": "PTK2B" }, { "db_name": "uniprot", "db_id": "Q14289" } ] }, { "id": "1.0alpha7.train.88.ent2_1", "type": "protein", "text": [ "Pyk2" ], "offsets": [ [ 23, 27 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2185" }, { "db_name": "hgnc", "db_id": "PTK2B" }, { "db_name": "uniprot", "db_id": "Q14289" } ] }, { "id": "1.0alpha7.train.88.ent3_0", "type": "protein", "text": [ "p130Cas" ], "offsets": [ [ 160, 167 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9564" }, { "db_name": "hgnc", "db_id": "BCAR1" }, { "db_name": "uniprot", "db_id": "P56945" } ] }, { "id": "1.0alpha7.train.88.ent4_0", "type": "protein", "text": [ "Grb2" ], "offsets": [ [ 127, 131 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2885" }, { "db_name": "hgnc", "db_id": "GRB2" }, { "db_name": "uniprot", "db_id": "P62993" } ] }, { "id": "1.0alpha7.train.88.ent5_0", "type": "protein", "text": [ "Shc" ], "offsets": [ [ 137, 140 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6464" }, { "db_name": "hgnc", "db_id": "SHC1" }, { "db_name": "uniprot", "db_id": "P29353" } ] }, { "id": "1.0alpha7.train.88.ent6_0", "type": "protein", "text": [ "Pyk2-Y402F" ], "offsets": [ [ 23, 33 ] ], "normalized": [] }, { "id": "1.0alpha7.train.88.ent7_0", "type": "protein-family", "text": [ "JNK" ], "offsets": [ [ 199, 202 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR008351" } ] }, { "id": "1.0alpha7.train.88.ent8_0", "type": "protein", "text": [ "Crk" ], "offsets": [ [ 153, 156 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1398" }, { "db_name": "hgnc", "db_id": "CRK" }, { "db_name": "uniprot", "db_id": "P46108" } ] }, { "id": "1.0alpha7.train.88.ent9_0", "type": "protein-family", "text": [ "ERK" ], "offsets": [ [ 191, 194 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.89
8949357
[ { "id": "1.0alpha7.train.89.sent", "type": "sentence", "text": [ "These results indicate that LIN-7 binds to LIN-2 and that LIN-2 binds to LIN-10 in vivo." ], "offsets": [ [ 0, 88 ] ] } ]
[ { "id": "1.0alpha7.train.89.ent0_0", "type": "protein", "text": [ "LIN-7" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8825" }, { "db_name": "hgnc", "db_id": "LIN7A" }, { "db_name": "uniprot", "db_id": "O14910" } ] }, { "id": "1.0alpha7.train.89.ent1_0", "type": "protein", "text": [ "LIN-2" ], "offsets": [ [ 43, 48 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8573" }, { "db_name": "hgnc", "db_id": "CASK" }, { "db_name": "uniprot", "db_id": "O14936" } ] }, { "id": "1.0alpha7.train.89.ent2_1", "type": "protein", "text": [ "LIN-2" ], "offsets": [ [ 58, 63 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8573" }, { "db_name": "hgnc", "db_id": "CASK" }, { "db_name": "uniprot", "db_id": "O14936" } ] }, { "id": "1.0alpha7.train.89.ent3_0", "type": "protein", "text": [ "LIN-10" ], "offsets": [ [ 73, 79 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "80262" }, { "db_name": "hgnc", "db_id": "C16orf70" }, { "db_name": "uniprot", "db_id": "Q9BSU1" } ] } ]
[]
[ { "id": "1.0alpha7.train.89.coref0", "entity_ids": [ "1.0alpha7.train.89.ent0_0" ] }, { "id": "1.0alpha7.train.89.coref1", "entity_ids": [ "1.0alpha7.train.89.ent1_0", "1.0alpha7.train.89.ent2_1" ] }, { "id": "1.0alpha7.train.89.coref2", "entity_ids": [ "1.0alpha7.train.89.ent3_0" ] } ]
[ { "id": "1.0alpha7.train.89.rel0s1.0alpha7.train.89.ent0_0.o1.0alpha7.train.89.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.89.ent0_0", "arg2_id": "1.0alpha7.train.89.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.89.rel0s1.0alpha7.train.89.ent0_0.o1.0alpha7.train.89.ent2_1", "type": "bind", "arg1_id": "1.0alpha7.train.89.ent0_0", "arg2_id": "1.0alpha7.train.89.ent2_1", "normalized": [] }, { "id": "1.0alpha7.train.89.rel1s1.0alpha7.train.89.ent1_0.o1.0alpha7.train.89.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.89.ent1_0", "arg2_id": "1.0alpha7.train.89.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.89.rel1s1.0alpha7.train.89.ent2_1.o1.0alpha7.train.89.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.89.ent2_1", "arg2_id": "1.0alpha7.train.89.ent3_0", "normalized": [] } ]
1.0alpha7.train.90
24605299
[ { "id": "1.0alpha7.train.90.sent", "type": "sentence", "text": [ "Binding of GMP to the GK domain of PSD-95 did not induce large conformational changes in the nucleoside binding domain, in contrast to yeast guanylate kinase (Blaszczyk et al., 2001 )." ], "offsets": [ [ 0, 184 ] ] } ]
[ { "id": "1.0alpha7.train.90.ent0_0", "type": "chemical", "text": [ "GMP" ], "offsets": [ [ 11, 14 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398631" } ] }, { "id": "1.0alpha7.train.90.ent1_0", "type": "protein-family", "text": [ "guanylate kinase" ], "offsets": [ [ 141, 157 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR017665" } ] }, { "id": "1.0alpha7.train.90.ent2_0", "type": "protein", "text": [ "PSD-95" ], "offsets": [ [ 35, 41 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1742" }, { "db_name": "hgnc", "db_id": "DLG4" }, { "db_name": "uniprot", "db_id": "P78352" } ] }, { "id": "1.0alpha7.train.90.ent3_0", "type": "protein-domain", "text": [ "GK domain" ], "offsets": [ [ 22, 31 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR008144" } ] } ]
[]
[ { "id": "1.0alpha7.train.90.coref0", "entity_ids": [ "1.0alpha7.train.90.ent0_0" ] }, { "id": "1.0alpha7.train.90.coref1", "entity_ids": [ "1.0alpha7.train.90.ent1_0" ] }, { "id": "1.0alpha7.train.90.coref2", "entity_ids": [ "1.0alpha7.train.90.ent2_0" ] }, { "id": "1.0alpha7.train.90.coref3", "entity_ids": [ "1.0alpha7.train.90.ent3_0" ] } ]
[ { "id": "1.0alpha7.train.90.rel0s1.0alpha7.train.90.ent0_0.o1.0alpha7.train.90.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.90.ent0_0", "arg2_id": "1.0alpha7.train.90.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.90.rel1s1.0alpha7.train.90.ent0_0.o1.0alpha7.train.90.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.90.ent0_0", "arg2_id": "1.0alpha7.train.90.ent1_0", "normalized": [] } ]
1.0alpha7.train.91
305922
[ { "id": "1.0alpha7.train.91.sent", "type": "sentence", "text": [ "In this model calcium stabilizes the binding of PKC to PS containing membranes (see also ( 2 , 3 , 4 , 6 ) )." ], "offsets": [ [ 0, 109 ] ] } ]
[ { "id": "1.0alpha7.train.91.ent0_0", "type": "chemical", "text": [ "calcium" ], "offsets": [ [ 14, 21 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5460341" } ] }, { "id": "1.0alpha7.train.91.ent1_0", "type": "chemical", "text": [ "PS" ], "offsets": [ [ 55, 57 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "52925988" } ] }, { "id": "1.0alpha7.train.91.ent2_0", "type": "protein-family", "text": [ "PKC" ], "offsets": [ [ 48, 51 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR014376" } ] } ]
[]
[ { "id": "1.0alpha7.train.91.coref0", "entity_ids": [ "1.0alpha7.train.91.ent0_0" ] }, { "id": "1.0alpha7.train.91.coref1", "entity_ids": [ "1.0alpha7.train.91.ent1_0" ] }, { "id": "1.0alpha7.train.91.coref2", "entity_ids": [ "1.0alpha7.train.91.ent2_0" ] } ]
[]
1.0alpha7.train.92
1570410
[ { "id": "1.0alpha7.train.92.sent", "type": "sentence", "text": [ "It is now apparent that 4E-BP1 inhibits the function of eIF4E in cap-dependent translation by blocking the binding of eIF4E to eIF4G, another component of the eIF4F complex." ], "offsets": [ [ 0, 173 ] ] } ]
[ { "id": "1.0alpha7.train.92.ent0_0", "type": "protein", "text": [ "eIF4E" ], "offsets": [ [ 56, 61 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1977" }, { "db_name": "hgnc", "db_id": "EIF4E" }, { "db_name": "uniprot", "db_id": "P06730" } ] }, { "id": "1.0alpha7.train.92.ent1_1", "type": "protein", "text": [ "eIF4E" ], "offsets": [ [ 118, 123 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1977" }, { "db_name": "hgnc", "db_id": "EIF4E" }, { "db_name": "uniprot", "db_id": "P06730" } ] }, { "id": "1.0alpha7.train.92.ent2_0", "type": "protein", "text": [ "eIF4G" ], "offsets": [ [ 127, 132 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1981" }, { "db_name": "hgnc", "db_id": "EIF4G1" }, { "db_name": "uniprot", "db_id": "Q04637" } ] }, { "id": "1.0alpha7.train.92.ent3_0", "type": "protein-complex", "text": [ "eIF4F" ], "offsets": [ [ 159, 164 ] ], "normalized": [] }, { "id": "1.0alpha7.train.92.ent4_0", "type": "protein", "text": [ "4E-BP1" ], "offsets": [ [ 24, 30 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1978" }, { "db_name": "hgnc", "db_id": "EIF4EBP1" }, { "db_name": "uniprot", "db_id": "Q13541" } ] } ]
[]
[ { "id": "1.0alpha7.train.92.coref0", "entity_ids": [ "1.0alpha7.train.92.ent0_0", "1.0alpha7.train.92.ent1_1" ] }, { "id": "1.0alpha7.train.92.coref1", "entity_ids": [ "1.0alpha7.train.92.ent2_0" ] }, { "id": "1.0alpha7.train.92.coref2", "entity_ids": [ "1.0alpha7.train.92.ent3_0" ] }, { "id": "1.0alpha7.train.92.coref3", "entity_ids": [ "1.0alpha7.train.92.ent4_0" ] } ]
[ { "id": "1.0alpha7.train.92.rel0s1.0alpha7.train.92.ent0_0.o1.0alpha7.train.92.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.92.ent0_0", "arg2_id": "1.0alpha7.train.92.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.92.rel0s1.0alpha7.train.92.ent1_1.o1.0alpha7.train.92.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.92.ent1_1", "arg2_id": "1.0alpha7.train.92.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.92.rel1s1.0alpha7.train.92.ent0_0.o1.0alpha7.train.92.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.92.ent0_0", "arg2_id": "1.0alpha7.train.92.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.92.rel1s1.0alpha7.train.92.ent1_1.o1.0alpha7.train.92.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.92.ent1_1", "arg2_id": "1.0alpha7.train.92.ent3_0", "normalized": [] } ]
1.0alpha7.train.93
25350899
[ { "id": "1.0alpha7.train.93.sent", "type": "sentence", "text": [ "ADF/ cofilin can directly bind to actin filaments and promote their disassembly (Carlier et al., 1999 ; Bamburg, 1999 )." ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "1.0alpha7.train.93.ent0_0", "type": "protein-family", "text": [ "ADF/ cofilin" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR017904" } ] }, { "id": "1.0alpha7.train.93.ent1_0", "type": "protein-family", "text": [ "actin" ], "offsets": [ [ 34, 39 ] ], "normalized": [ { "db_name": "pfam", "db_id": "PF00022" } ] } ]
[]
[ { "id": "1.0alpha7.train.93.coref0", "entity_ids": [ "1.0alpha7.train.93.ent0_0" ] }, { "id": "1.0alpha7.train.93.coref1", "entity_ids": [ "1.0alpha7.train.93.ent1_0" ] } ]
[ { "id": "1.0alpha7.train.93.rel0s1.0alpha7.train.93.ent0_0.o1.0alpha7.train.93.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.93.ent0_0", "arg2_id": "1.0alpha7.train.93.ent1_0", "normalized": [] } ]

Dataset Card for BioRelEx

BioRelEx is a biological relation extraction dataset. Version 1.0 contains 2010 annotated sentences that describe binding interactions between various biological entities (proteins, chemicals, etc.). 1405 sentences are for training, another 201 sentences are for validation. They are publicly available at https://github.com/YerevaNN/BioRelEx/releases. Another 404 sentences are for testing which are kept private for at this Codalab competition https://competitions.codalab.org/competitions/20468. All sentences contain words "bind", "bound" or "binding". For every sentence we provide: 1) Complete annotations of all biological entities that appear in the sentence 2) Entity types (32 types) and grounding information for most of the proteins and families (links to uniprot, interpro and other databases) 3) Coreference between entities in the same sentence (e.g. abbreviations and synonyms) 4) Binding interactions between the annotated entities 5) Binding interaction types: positive, negative (A does not bind B) and neutral (A may bind to B)

Citation Information

@inproceedings{khachatrian2019biorelex,
    title = "{B}io{R}el{E}x 1.0: Biological Relation Extraction Benchmark",
    author = "Khachatrian, Hrant  and
      Nersisyan, Lilit  and
      Hambardzumyan, Karen  and
      Galstyan, Tigran  and
      Hakobyan, Anna  and
      Arakelyan, Arsen  and
      Rzhetsky, Andrey  and
      Galstyan, Aram",
    booktitle = "Proceedings of the 18th BioNLP Workshop and Shared Task",
    month = aug,
    year = "2019",
    address = "Florence, Italy",
    publisher = "Association for Computational Linguistics",
    url = "https://aclanthology.org/W19-5019",
    doi = "10.18653/v1/W19-5019",
    pages = "176--190"
}
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