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1.0alpha7.train.100
5566553
[ { "id": "1.0alpha7.train.100.sent", "type": "sentence", "text": [ "In this study, I examined the Rab binding activities of Rim1, Rim2, Noc2, and rabphilin by cotransfection assay in COS-7 cells using 42 different Rab proteins (including 37 subfamilies reported in the mouse data bases (18, 19)) and found that these molecules exhibit distinct Rab binding specificity. " ], "offsets": [ [ 0, 301 ] ] } ]
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[]
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1.0alpha7.train.101
1084839
[ { "id": "1.0alpha7.train.101.sent", "type": "sentence", "text": [ "Alternatively, auxilin might bind much more weakly to Hsc70 in ADP than ATP." ], "offsets": [ [ 0, 76 ] ] } ]
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[]
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1.0alpha7.train.102
11274680
[ { "id": "1.0alpha7.train.102.sent", "type": "sentence", "text": [ "However, these mutations greatly diminished (G423A) or abolished (Y426A and RQ428, 429AA) Smad2 binding to the TGF‐β receptor complex (Table I)." ], "offsets": [ [ 0, 144 ] ] } ]
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[]
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1.0alpha7.train.103
11376780
[ { "id": "1.0alpha7.train.103.sent", "type": "sentence", "text": [ "Like its yeast counterpart, purified human SWI-SNF complex contains ATP-dependent nucleosome disruption activity that leads to facilitated binding of TBP and Gal4 derivatives to synthetic promoters (Imbalzano et al., 1994 ; Kwon et al., 1994)." ], "offsets": [ [ 0, 252 ] ] } ]
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[]
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[]
1.0alpha7.train.104
22557001
[ { "id": "1.0alpha7.train.104.sent", "type": "sentence", "text": [ "The inability of tyrosine-phosphorylated SLP-76 to interact with nck(SH2*) was not due to a gross conformational change induced by the R308K mutation, as nck(SH2*) still bound cbl, an interaction that is mediated through the N-terminal SH3 domain of nck (bottom panel) (Rivero-Lezcano et al. 1994). " ], "offsets": [ [ 0, 299 ] ] } ]
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[]
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1.0alpha7.train.105
3584765
[ { "id": "1.0alpha7.train.105.sent", "type": "sentence", "text": [ " Since Dvl-1 also binds directly to this region of Axin ( 26), we examined whether Dvl and Axam share the same binding site on Axin. " ], "offsets": [ [ 0, 139 ] ] } ]
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[]
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1.0alpha7.train.106
8936681
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1.0alpha7.train.107
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1.0alpha7.train.108
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1.0alpha7.train.109
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1.0alpha7.train.110
4164520
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1.0alpha7.train.111
22482077
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1.0alpha7.train.112
12612407
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1.0alpha7.train.113
2191110
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[]
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1.0alpha7.train.114
9486072
[ { "id": "1.0alpha7.train.114.sent", "type": "sentence", "text": [ "Cortactin Binds the Arp2/3 Complex through Sequences in the NTA Region" ], "offsets": [ [ 0, 70 ] ] } ]
[ { "id": "1.0alpha7.train.114.ent0_0", "type": "protein-motif", "text": [ "NTA" ], "offsets": [ [ 60, 63 ] ], "normalized": [] }, { "id": "1.0alpha7.train.114.ent1_0", "type": "protein", "text": [ "Cortactin" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2017" }, { "db_name": "hgnc", "db_id": "CTTN" }, { "db_name": "uniprot", "db_id": "Q14247" } ] }, { "id": "1.0alpha7.train.114.ent2_0", "type": "protein-complex", "text": [ "Arp2/3" ], "offsets": [ [ 20, 26 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.114.coref0", "entity_ids": [ "1.0alpha7.train.114.ent0_0" ] }, { "id": "1.0alpha7.train.114.coref1", "entity_ids": [ "1.0alpha7.train.114.ent1_0" ] }, { "id": "1.0alpha7.train.114.coref2", "entity_ids": [ "1.0alpha7.train.114.ent2_0" ] } ]
[ { "id": "1.0alpha7.train.114.rel0s1.0alpha7.train.114.ent1_0.o1.0alpha7.train.114.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.114.ent1_0", "arg2_id": "1.0alpha7.train.114.ent2_0", "normalized": [] } ]
1.0alpha7.train.115
9486072
[ { "id": "1.0alpha7.train.115.sent", "type": "sentence", "text": [ "To identify the region within the cortactin amino terminus responsible for associating with the Arp2/3 complex, Sepharose beads covalently coupled to the NTA and repeats regions were incubated with 10T1/2 fibroblast lysate, and Arp2/3 binding was assayed by immunoblotting (Fig. 6 A). " ], "offsets": [ [ 0, 285 ] ] } ]
[ { "id": "1.0alpha7.train.115.ent0_0", "type": "protein-motif", "text": [ "NTA" ], "offsets": [ [ 154, 157 ] ], "normalized": [] }, { "id": "1.0alpha7.train.115.ent1_0", "type": "assay", "text": [ "10T1/2" ], "offsets": [ [ 198, 204 ] ], "normalized": [] }, { "id": "1.0alpha7.train.115.ent2_0", "type": "chemical", "text": [ "Sepharose" ], "offsets": [ [ 112, 121 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "11966311" } ] }, { "id": "1.0alpha7.train.115.ent3_0", "type": "protein-complex", "text": [ "Arp2/3" ], "offsets": [ [ 96, 102 ] ], "normalized": [] }, { "id": "1.0alpha7.train.115.ent4_1", "type": "protein-complex", "text": [ "Arp2/3" ], "offsets": [ [ 228, 234 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.115.coref0", "entity_ids": [ "1.0alpha7.train.115.ent0_0" ] }, { "id": "1.0alpha7.train.115.coref1", "entity_ids": [ "1.0alpha7.train.115.ent1_0" ] }, { "id": "1.0alpha7.train.115.coref2", "entity_ids": [ "1.0alpha7.train.115.ent2_0" ] }, { "id": "1.0alpha7.train.115.coref3", "entity_ids": [ "1.0alpha7.train.115.ent3_0", "1.0alpha7.train.115.ent4_1" ] } ]
[]
1.0alpha7.train.116
3218892
[ { "id": "1.0alpha7.train.116.sent", "type": "sentence", "text": [ "This value, which can also be deduced from the HPLC elution pattern after calibration with standard proteins of known Stokes radii (Figs. 5 A and 6 A, 5.5 ± 0.3 nm), is identical to that for ATPase in C12E8 (22) (the sedimentation coefficient for Ca2+-ATPase monomers in DM is larger than that for Ca2+-ATPase monomers in C12E8, 7.62 S (this work) versus 5.1 S (45), mainly because DM is more dense than C12E8 (DM has a partial specific volume smaller than that of C12E8, 0.82 (Ref.46) versus 0.97 cm3/g (Ref. 23)), and also because the protein binds slightly more (23) DM than C12E8)." ], "offsets": [ [ 0, 585 ] ] } ]
[ { "id": "1.0alpha7.train.116.ent0_0", "type": "protein-family", "text": [ "ATPase" ], "offsets": [ [ 191, 197 ] ], "normalized": [] }, { "id": "1.0alpha7.train.116.ent1_1", "type": "protein-family", "text": [ "ATPase" ], "offsets": [ [ 252, 258 ] ], "normalized": [] }, { "id": "1.0alpha7.train.116.ent2_2", "type": "protein-family", "text": [ "ATPase" ], "offsets": [ [ 303, 309 ] ], "normalized": [] }, { "id": "1.0alpha7.train.116.ent3_0", "type": "chemical", "text": [ "C12E8" ], "offsets": [ [ 201, 206 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "123921" } ] }, { "id": "1.0alpha7.train.116.ent4_1", "type": "chemical", "text": [ "C12E8" ], "offsets": [ [ 322, 327 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "123921" } ] }, { "id": "1.0alpha7.train.116.ent5_2", "type": "chemical", "text": [ "C12E8" ], "offsets": [ [ 404, 409 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "123921" } ] }, { "id": "1.0alpha7.train.116.ent6_3", "type": "chemical", "text": [ "C12E8" ], "offsets": [ [ 465, 470 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "123921" } ] }, { "id": "1.0alpha7.train.116.ent7_4", "type": "chemical", "text": [ "C12E8" ], "offsets": [ [ 578, 583 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "123921" } ] }, { "id": "1.0alpha7.train.116.ent8_0", "type": "assay", "text": [ "HPLC" ], "offsets": [ [ 47, 51 ] ], "normalized": [] }, { "id": "1.0alpha7.train.116.ent9_0", "type": "chemical", "text": [ "DM" ], "offsets": [ [ 271, 273 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "445456" } ] }, { "id": "1.0alpha7.train.116.ent10_1", "type": "chemical", "text": [ "DM" ], "offsets": [ [ 382, 384 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "445456" } ] }, { "id": "1.0alpha7.train.116.ent11_2", "type": "chemical", "text": [ "DM" ], "offsets": [ [ 411, 413 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "445456" } ] }, { "id": "1.0alpha7.train.116.ent12_3", "type": "chemical", "text": [ "DM" ], "offsets": [ [ 570, 572 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "445456" } ] }, { "id": "1.0alpha7.train.116.ent13_0", "type": "protein", "text": [ "Ca2+-ATPase" ], "offsets": [ [ 247, 258 ] ], "normalized": [] }, { "id": "1.0alpha7.train.116.ent14_1", "type": "protein", "text": [ "Ca2+-ATPase" ], "offsets": [ [ 298, 309 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.116.coref0", "entity_ids": [ "1.0alpha7.train.116.ent0_0", "1.0alpha7.train.116.ent1_1", "1.0alpha7.train.116.ent2_2" ] }, { "id": "1.0alpha7.train.116.coref1", "entity_ids": [ "1.0alpha7.train.116.ent3_0", "1.0alpha7.train.116.ent4_1", "1.0alpha7.train.116.ent5_2", "1.0alpha7.train.116.ent6_3", "1.0alpha7.train.116.ent7_4" ] }, { "id": "1.0alpha7.train.116.coref2", "entity_ids": [ "1.0alpha7.train.116.ent8_0" ] }, { "id": "1.0alpha7.train.116.coref3", "entity_ids": [ "1.0alpha7.train.116.ent9_0", "1.0alpha7.train.116.ent10_1", "1.0alpha7.train.116.ent11_2", "1.0alpha7.train.116.ent12_3" ] }, { "id": "1.0alpha7.train.116.coref4", "entity_ids": [ "1.0alpha7.train.116.ent13_0", "1.0alpha7.train.116.ent14_1" ] } ]
[]
1.0alpha7.train.117
24832606
[ { "id": "1.0alpha7.train.117.sent", "type": "sentence", "text": [ "Comparison of the Kapp values in the absence of agonist versus those in the presence of agonist suggests that CrV binding strongly favors the desensitized conformation of the AChR because this is the conformation stabilized by agonists at equilibrium." ], "offsets": [ [ 0, 251 ] ] } ]
[ { "id": "1.0alpha7.train.117.ent0_0", "type": "chemical", "text": [ "CrV" ], "offsets": [ [ 110, 113 ] ], "normalized": [] }, { "id": "1.0alpha7.train.117.ent1_0", "type": "protein-family", "text": [ "AChR" ], "offsets": [ [ 175, 179 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.117.coref0", "entity_ids": [ "1.0alpha7.train.117.ent0_0" ] }, { "id": "1.0alpha7.train.117.coref1", "entity_ids": [ "1.0alpha7.train.117.ent1_0" ] } ]
[ { "id": "1.0alpha7.train.117.rel0s1.0alpha7.train.117.ent0_0.o1.0alpha7.train.117.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.117.ent0_0", "arg2_id": "1.0alpha7.train.117.ent1_0", "normalized": [] } ]
1.0alpha7.train.118
25596381
[ { "id": "1.0alpha7.train.118.sent", "type": "sentence", "text": [ "A more pronounced increase in [3] GABA binding to Hydra membranes was apparent in the presence of general anaesthetics ( Fig. 1A)." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "1.0alpha7.train.118.ent0_0", "type": "experimental-construct", "text": [ "Hydra membranes" ], "offsets": [ [ 50, 65 ] ], "normalized": [] }, { "id": "1.0alpha7.train.118.ent1_0", "type": "chemical", "text": [ "GABA" ], "offsets": [ [ 34, 38 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "119" } ] } ]
[]
[ { "id": "1.0alpha7.train.118.coref0", "entity_ids": [ "1.0alpha7.train.118.ent0_0" ] }, { "id": "1.0alpha7.train.118.coref1", "entity_ids": [ "1.0alpha7.train.118.ent1_0" ] } ]
[]
1.0alpha7.train.119
20576331
[ { "id": "1.0alpha7.train.119.sent", "type": "sentence", "text": [ "Notably, binding to E-cadherin and APC seems to be mutually exclusive, and β-catenin bound to cadherins in adherens junctions should be therefore inaccessible to APC-mediated degradation. " ], "offsets": [ [ 0, 188 ] ] } ]
[ { "id": "1.0alpha7.train.119.ent0_0", "type": "protein", "text": [ "APC" ], "offsets": [ [ 35, 38 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.119.ent1_1", "type": "protein", "text": [ "APC" ], "offsets": [ [ 162, 165 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "324" }, { "db_name": "hgnc", "db_id": "APC" } ] }, { "id": "1.0alpha7.train.119.ent2_0", "type": "protein-family", "text": [ "cadherins" ], "offsets": [ [ 94, 103 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039808" } ] }, { "id": "1.0alpha7.train.119.ent3_0", "type": "protein", "text": [ "catenin" ], "offsets": [ [ 77, 84 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1495" }, { "db_name": "hgnc", "db_id": "CTNNA1" }, { "db_name": "uniprot", "db_id": "P35221" } ] }, { "id": "1.0alpha7.train.119.ent4_0", "type": "protein", "text": [ "E-cadherin" ], "offsets": [ [ 20, 30 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "999" }, { "db_name": "hgnc", "db_id": "CDH1" }, { "db_name": "uniprot", "db_id": "P12830" } ] } ]
[]
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[ { "id": "1.0alpha7.train.119.rel0s1.0alpha7.train.119.ent2_0.o1.0alpha7.train.119.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.119.ent2_0", "arg2_id": "1.0alpha7.train.119.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.119.rel1s1.0alpha7.train.119.ent0_0.o1.0alpha7.train.119.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.119.ent0_0", "arg2_id": "1.0alpha7.train.119.ent3_0", "normalized": [] }, { "id": "1.0alpha7.train.119.rel1s1.0alpha7.train.119.ent1_1.o1.0alpha7.train.119.ent3_0", "type": "bind", "arg1_id": "1.0alpha7.train.119.ent1_1", "arg2_id": "1.0alpha7.train.119.ent3_0", "normalized": [] } ]
1.0alpha7.train.120
864980
[ { "id": "1.0alpha7.train.120.sent", "type": "sentence", "text": [ " It was found to bind to collagen type I, but collagen preincubated in a dot blot assay with heparin did not bind any longerR to APP. " ], "offsets": [ [ 0, 141 ] ] } ]
[ { "id": "1.0alpha7.train.120.ent0_0", "type": "chemical", "text": [ "heparin" ], "offsets": [ [ 98, 105 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "772" } ] }, { "id": "1.0alpha7.train.120.ent1_0", "type": "protein", "text": [ "APP" ], "offsets": [ [ 135, 138 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "351" }, { "db_name": "hgnc", "db_id": "APP" } ] }, { "id": "1.0alpha7.train.120.ent2_0", "type": "protein-complex", "text": [ "collagen" ], "offsets": [ [ 27, 35 ] ], "normalized": [] }, { "id": "1.0alpha7.train.120.ent3_1", "type": "protein-complex", "text": [ "collagen" ], "offsets": [ [ 49, 57 ] ], "normalized": [] }, { "id": "1.0alpha7.train.120.ent4_0", "type": "protein-complex", "text": [ "collagen type I" ], "offsets": [ [ 27, 42 ] ], "normalized": [] } ]
[]
[ { "id": "1.0alpha7.train.120.coref0", "entity_ids": [ "1.0alpha7.train.120.ent0_0" ] }, { "id": "1.0alpha7.train.120.coref1", "entity_ids": [ "1.0alpha7.train.120.ent1_0" ] }, { "id": "1.0alpha7.train.120.coref2", "entity_ids": [ "1.0alpha7.train.120.ent2_0", "1.0alpha7.train.120.ent3_1", "1.0alpha7.train.120.ent4_0" ] } ]
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1.0alpha7.train.121
1559207
[ { "id": "1.0alpha7.train.121.sent", "type": "sentence", "text": [ "JNK/SAPK Binds and Phosphorylates a MEKK1 Fragment In Vitro" ], "offsets": [ [ 0, 59 ] ] } ]
[ { "id": "1.0alpha7.train.121.ent0_0", "type": "protein", "text": [ "JNK" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5599" }, { "db_name": "hgnc", "db_id": "MAPK8" }, { "db_name": "uniprot", "db_id": "P45983" } ] }, { "id": "1.0alpha7.train.121.ent1_0", "type": "protein", "text": [ "MEKK1" ], "offsets": [ [ 36, 41 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "4214" }, { "db_name": "hgnc", "db_id": "MAP3K1" }, { "db_name": "uniprot", "db_id": "Q13233" } ] }, { "id": "1.0alpha7.train.121.ent2_0", "type": "protein", "text": [ "SAPK" ], "offsets": [ [ 4, 8 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5599" }, { "db_name": "hgnc", "db_id": "MAPK8" }, { "db_name": "uniprot", "db_id": "P45983" } ] } ]
[]
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1.0alpha7.train.122
22450916
[ { "id": "1.0alpha7.train.122.sent", "type": "sentence", "text": [ "Since both of the Sp1 binding sequences (GGGTGG) showed variations of the Sp1 consensus binding sequences (GGGCGG), a single T (m1, m2) and both Ts (m4) of the variant Sp1 sites were changed into C, in order to test the ability of the Sp1 consensus binding (GGGCGG) sequences to confer PTEN-mediated transcriptional regulation (Fig. 2Ba)." ], "offsets": [ [ 0, 338 ] ] } ]
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[]
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1.0alpha7.train.123
3395839
[ { "id": "1.0alpha7.train.123.sent", "type": "sentence", "text": [ "Interestingly, using the SPR, the binding of GFRalpha2-Fc to GDNF could not be detected." ], "offsets": [ [ 0, 88 ] ] } ]
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[]
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1.0alpha7.train.124
1926592
[ { "id": "1.0alpha7.train.124.sent", "type": "sentence", "text": [ " In the case of the c- myc promoter, in addition to hnRNP K and CNBP, the CT element can also be bound by Sp1. " ], "offsets": [ [ 0, 117 ] ] } ]
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[]
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1.0alpha7.train.125
15275220
[ { "id": "1.0alpha7.train.125.sent", "type": "sentence", "text": [ "However, in the absence of Phyl, barely detectable levels of Sina bound Ttk-HA." ], "offsets": [ [ 0, 79 ] ] } ]
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[]
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1.0alpha7.train.126
2648477
[ { "id": "1.0alpha7.train.126.sent", "type": "sentence", "text": [ "poly( dC)-agarose; lane 3, DADA mutant protein bound to poly( dI)." ], "offsets": [ [ 0, 66 ] ] } ]
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[]
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[]
1.0alpha7.train.127
9285542
[ { "id": "1.0alpha7.train.127.sent", "type": "sentence", "text": [ "However, not all SM proteins directly bind to syntaxins, and no decrease in Sso1p/2p is observed in Sec1p null mutants in yeast." ], "offsets": [ [ 0, 128 ] ] } ]
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[]
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1.0alpha7.train.128
25266276
[ { "id": "1.0alpha7.train.128.sent", "type": "sentence", "text": [ "Binding of neuroligins to PSD-95." ], "offsets": [ [ 0, 33 ] ] } ]
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[]
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1.0alpha7.train.129
3129111
[ { "id": "1.0alpha7.train.129.sent", "type": "sentence", "text": [ "TFIIA binds directly to TBP and at least one TBP-associated factor (TAF) in the TFIID complex ( 7)." ], "offsets": [ [ 0, 99 ] ] } ]
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[]
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1.0alpha7.train.130
9252666
[ { "id": "1.0alpha7.train.130.sent", "type": "sentence", "text": [ " A small increase in salt concentration in the lysis buffer slightly reduced the amount of raptor bound to mTOR, and this correlated with a corresponding increase in mTOR activity. " ], "offsets": [ [ 0, 185 ] ] } ]
[ { "id": "1.0alpha7.train.130.ent0_0", "type": "protein", "text": [ "mTOR" ], "offsets": [ [ 109, 113 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2475" }, { "db_name": "hgnc", "db_id": "MTOR" }, { "db_name": "uniprot", "db_id": "P42345" } ] }, { "id": "1.0alpha7.train.130.ent1_1", "type": "protein", "text": [ "mTOR" ], "offsets": [ [ 169, 173 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2475" }, { "db_name": "hgnc", "db_id": "MTOR" }, { "db_name": "uniprot", "db_id": "P42345" } ] }, { "id": "1.0alpha7.train.130.ent2_0", "type": "protein", "text": [ "raptor" ], "offsets": [ [ 92, 98 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "57521" }, { "db_name": "hgnc", "db_id": "RPTOR" }, { "db_name": "uniprot", "db_id": "Q8N122" } ] } ]
[]
[ { "id": "1.0alpha7.train.130.coref0", "entity_ids": [ "1.0alpha7.train.130.ent0_0", "1.0alpha7.train.130.ent1_1" ] }, { "id": "1.0alpha7.train.130.coref1", "entity_ids": [ "1.0alpha7.train.130.ent2_0" ] } ]
[ { "id": "1.0alpha7.train.130.rel0s1.0alpha7.train.130.ent0_0.o1.0alpha7.train.130.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.130.ent0_0", "arg2_id": "1.0alpha7.train.130.ent2_0", "normalized": [] }, { "id": "1.0alpha7.train.130.rel0s1.0alpha7.train.130.ent1_1.o1.0alpha7.train.130.ent2_0", "type": "bind", "arg1_id": "1.0alpha7.train.130.ent1_1", "arg2_id": "1.0alpha7.train.130.ent2_0", "normalized": [] } ]
1.0alpha7.train.131
24680614
[ { "id": "1.0alpha7.train.131.sent", "type": "sentence", "text": [ "Control experiments confirmed retention of EGFR binding by the mutant form of c-Cbl." ], "offsets": [ [ 0, 84 ] ] } ]
[ { "id": "1.0alpha7.train.131.ent0_0", "type": "protein", "text": [ "c-Cbl" ], "offsets": [ [ 78, 83 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "867" }, { "db_name": "hgnc", "db_id": "CBL" }, { "db_name": "uniprot", "db_id": "P22681" } ] }, { "id": "1.0alpha7.train.131.ent1_0", "type": "protein", "text": [ "EGFR" ], "offsets": [ [ 43, 47 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1956" }, { "db_name": "hgnc", "db_id": "EGFR" }, { "db_name": "uniprot", "db_id": "P00533" } ] } ]
[]
[ { "id": "1.0alpha7.train.131.coref0", "entity_ids": [ "1.0alpha7.train.131.ent0_0" ] }, { "id": "1.0alpha7.train.131.coref1", "entity_ids": [ "1.0alpha7.train.131.ent1_0" ] } ]
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1.0alpha7.train.132
4494959
[ { "id": "1.0alpha7.train.132.sent", "type": "sentence", "text": [ "The rate of ADP binding to ( k+AD) and dissociation from ( k AD) actomyosin are too fast to be measured using the method described here." ], "offsets": [ [ 0, 136 ] ] } ]
[ { "id": "1.0alpha7.train.132.ent0_0", "type": "protein-family", "text": [ "actomyosin" ], "offsets": [ [ 65, 75 ] ], "normalized": [] }, { "id": "1.0alpha7.train.132.ent1_0", "type": "chemical", "text": [ "ADP" ], "offsets": [ [ 12, 15 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "6022" } ] } ]
[]
[ { "id": "1.0alpha7.train.132.coref0", "entity_ids": [ "1.0alpha7.train.132.ent0_0" ] }, { "id": "1.0alpha7.train.132.coref1", "entity_ids": [ "1.0alpha7.train.132.ent1_0" ] } ]
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1.0alpha7.train.133
12658341
[ { "id": "1.0alpha7.train.133.sent", "type": "sentence", "text": [ "To verify that U2AF65 bound to the Py tract, we constructed and analyzed Py tract deletion mutants muMPy and muMdeltaPy (see Fig. 1A)." ], "offsets": [ [ 0, 134 ] ] } ]
[ { "id": "1.0alpha7.train.133.ent0_0", "type": "DNA", "text": [ "muMPy" ], "offsets": [ [ 99, 104 ] ], "normalized": [] }, { "id": "1.0alpha7.train.133.ent1_0", "type": "DNA", "text": [ "muMdeltaPy" ], "offsets": [ [ 109, 119 ] ], "normalized": [] }, { "id": "1.0alpha7.train.133.ent2_0", "type": "protein", "text": [ "U2AF65" ], "offsets": [ [ 15, 21 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "11338" }, { "db_name": "hgnc", "db_id": "U2AF2" }, { "db_name": "uniprot", "db_id": "P26368" } ] }, { "id": "1.0alpha7.train.133.ent3_0", "type": "DNA", "text": [ "Py tract" ], "offsets": [ [ 35, 43 ] ], "normalized": [] }, { "id": "1.0alpha7.train.133.ent4_1", "type": "DNA", "text": [ "Py tract" ], "offsets": [ [ 73, 81 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.134
15268380
[ { "id": "1.0alpha7.train.134.sent", "type": "sentence", "text": [ "To examine whether CRT binds to the SL structure, we tested the interaction of CRT with a short sORF oligomer and with a longer oligomer, FL-LAP, which covers the region of C/EBPβ mRNA from the first (FL) to the second (LAP) AUG codons (Fig. ​(Fig.1)1) (see Materials and Methods)." ], "offsets": [ [ 0, 281 ] ] } ]
[ { "id": "1.0alpha7.train.134.ent0_0", "type": "RNA", "text": [ "AUG" ], "offsets": [ [ 225, 228 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent1_0", "type": "protein", "text": [ "CRT" ], "offsets": [ [ 19, 22 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "811" }, { "db_name": "hgnc", "db_id": "CALR" }, { "db_name": "uniprot", "db_id": "P27797" } ] }, { "id": "1.0alpha7.train.134.ent2_1", "type": "protein", "text": [ "CRT" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "811" }, { "db_name": "hgnc", "db_id": "CALR" }, { "db_name": "uniprot", "db_id": "P27797" } ] }, { "id": "1.0alpha7.train.134.ent3_0", "type": "RNA", "text": [ "SL structure" ], "offsets": [ [ 36, 48 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent4_0", "type": "experiment-tag", "text": [ "FL" ], "offsets": [ [ 138, 140 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent5_1", "type": "experiment-tag", "text": [ "FL" ], "offsets": [ [ 201, 203 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent6_0", "type": "experiment-tag", "text": [ "FL-LAP" ], "offsets": [ [ 138, 144 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent7_0", "type": "RNA", "text": [ "C/EBPβ mRNA" ], "offsets": [ [ 173, 184 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1051" }, { "db_name": "hgnc", "db_id": "CEBPB" } ] }, { "id": "1.0alpha7.train.134.ent8_0", "type": "experiment-tag", "text": [ "LAP" ], "offsets": [ [ 141, 144 ] ], "normalized": [] }, { "id": "1.0alpha7.train.134.ent9_1", "type": "experiment-tag", "text": [ "LAP" ], "offsets": [ [ 220, 223 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.135
4211397
[ { "id": "1.0alpha7.train.135.sent", "type": "sentence", "text": [ "NAD(H) binds to dI, and NADP(H) binds to dIII; these two components protrude from the membrane (into the bacterial cytoplasm or mitochondrial matrix)." ], "offsets": [ [ 0, 150 ] ] } ]
[ { "id": "1.0alpha7.train.135.ent0_0", "type": "chemical", "text": [ "NAD(H)" ], "offsets": [ [ 0, 6 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "925" } ] }, { "id": "1.0alpha7.train.135.ent1_0", "type": "chemical", "text": [ "NADP(H)" ], "offsets": [ [ 24, 31 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5885" } ] }, { "id": "1.0alpha7.train.135.ent2_0", "type": "protein-domain", "text": [ "dIII" ], "offsets": [ [ 41, 45 ] ], "normalized": [] }, { "id": "1.0alpha7.train.135.ent3_0", "type": "protein-domain", "text": [ "dI" ], "offsets": [ [ 16, 18 ] ], "normalized": [] } ]
[]
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[]
1.0alpha7.train.136
12515287
[ { "id": "1.0alpha7.train.136.sent", "type": "sentence", "text": [ "Aside from TFIID binding to the Inr, it has also been observed that purified RNA polymerase II (or RNA polymerase II along with TBP, TFIIB, TFIIF) is able to recognize the Inr and to mediate transcription in an Inr-dependent manner in the absence of TAFs (Carcamo et al. 1991; Weis and Reinberg 1997)." ], "offsets": [ [ 0, 301 ] ] } ]
[ { "id": "1.0alpha7.train.136.ent0_0", "type": "protein", "text": [ "TFIIB" ], "offsets": [ [ 133, 138 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2959" }, { "db_name": "hgnc", "db_id": "GTF2B" }, { "db_name": "uniprot", "db_id": "Q00403" } ] }, { "id": "1.0alpha7.train.136.ent1_0", "type": "protein-domain", "text": [ "TAFs" ], "offsets": [ [ 250, 254 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR004823" } ] }, { "id": "1.0alpha7.train.136.ent2_0", "type": "protein", "text": [ "TBP" ], "offsets": [ [ 128, 131 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.136.ent3_0", "type": "DNA", "text": [ "Inr" ], "offsets": [ [ 32, 35 ] ], "normalized": [] }, { "id": "1.0alpha7.train.136.ent4_1", "type": "DNA", "text": [ "Inr" ], "offsets": [ [ 172, 175 ] ], "normalized": [] }, { "id": "1.0alpha7.train.136.ent5_2", "type": "DNA", "text": [ "Inr" ], "offsets": [ [ 211, 214 ] ], "normalized": [] }, { "id": "1.0alpha7.train.136.ent6_0", "type": "protein-complex", "text": [ "RNA polymerase II" ], "offsets": [ [ 77, 94 ] ], "normalized": [] }, { "id": "1.0alpha7.train.136.ent7_1", "type": "protein-complex", "text": [ "RNA polymerase II" ], "offsets": [ [ 99, 116 ] ], "normalized": [] }, { "id": "1.0alpha7.train.136.ent8_0", "type": "protein", "text": [ "TFIID" ], "offsets": [ [ 11, 16 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.136.ent9_0", "type": "protein", "text": [ "TFIIF" ], "offsets": [ [ 140, 145 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2962" }, { "db_name": "hgnc", "db_id": "GTF2F1" }, { "db_name": "uniprot", "db_id": "P35269" } ] } ]
[]
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1.0alpha7.train.137
11251583
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[]
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1.0alpha7.train.138
13135266
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[]
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1.0alpha7.train.139
19576446
[ { "id": "1.0alpha7.train.139.sent", "type": "sentence", "text": [ "For Gsb might be able to recognize some Ey binding sites even in the absence of its homeodomain, and binding of Gsb to Ey might depend on both its paired domain and C-terminal portion." ], "offsets": [ [ 0, 184 ] ] } ]
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[]
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1.0alpha7.train.140
18275217
[ { "id": "1.0alpha7.train.140.sent", "type": "sentence", "text": [ "Binding of HsOrc1 and HsCdc6 to GST was not detectable (lanes 2 and 6), confirming that the interaction was mediated by the HsCdc6 portion of the fusion protein." ], "offsets": [ [ 0, 161 ] ] } ]
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[]
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1.0alpha7.train.141
888168
[ { "id": "1.0alpha7.train.141.sent", "type": "sentence", "text": [ "PKA phosphorylation of adducin reduced activity of adducin in association with spectrin-actin complexes and in promoting binding of spectrin to F-actin." ], "offsets": [ [ 0, 152 ] ] } ]
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[]
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1.0alpha7.train.142
12649879
[ { "id": "1.0alpha7.train.142.sent", "type": "sentence", "text": [ "p23 and Hsp90 bind hTERT." ], "offsets": [ [ 0, 25 ] ] } ]
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[]
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1.0alpha7.train.143
9803938
[ { "id": "1.0alpha7.train.143.sent", "type": "sentence", "text": [ "It is hard to imagine how ADF binding to an actin monomer could increase the rate of its thermally driven collision with a filament end." ], "offsets": [ [ 0, 136 ] ] } ]
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[]
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1.0alpha7.train.144
4786682
[ { "id": "1.0alpha7.train.144.sent", "type": "sentence", "text": [ "Fig. 3 A shows that both the full-length and the amino-terminal p53 fragment binds to CR2 ( lanes 5 and 8)." ], "offsets": [ [ 0, 107 ] ] } ]
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[]
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1.0alpha7.train.145
3410123
[ { "id": "1.0alpha7.train.145.sent", "type": "sentence", "text": [ "Unlike the Sir protein and bromo domain interactions, HP1 binding to H4 tail peptides appears to be unaffected by acetylation." ], "offsets": [ [ 0, 126 ] ] } ]
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[]
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1.0alpha7.train.146
2892590
[ { "id": "1.0alpha7.train.146.sent", "type": "sentence", "text": [ "Additionally, we show here that FKBP52 binds directly to the GR." ], "offsets": [ [ 0, 64 ] ] } ]
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[]
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1.0alpha7.train.147
8964613
[ { "id": "1.0alpha7.train.147.sent", "type": "sentence", "text": [ "Treatment with C3 exoenzyme (C3) may block m1 mAChR - mediated suppression of Kv1.2 or may disrupt the binding between RhoA and Kv1.2." ], "offsets": [ [ 0, 134 ] ] } ]
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[]
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1.0alpha7.train.148
23474591
[ { "id": "1.0alpha7.train.148.sent", "type": "sentence", "text": [ "In addition, changes to tau also regulated this interaction, as shown by the altered binding of S100β to the AD-related hyperphosphorylated NFT-tau." ], "offsets": [ [ 0, 148 ] ] } ]
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[]
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1.0alpha7.train.149
939722
[ { "id": "1.0alpha7.train.149.sent", "type": "sentence", "text": [ "Tnfr1 and Tnfr2 bind Tnfα and Tnfβ with similar high equilibrium affinity, but they differ significantly in their Tnfα binding kinetics; Tnfα bound to Tnfr2 is exchanged at a significantly faster rate than when complexed with Tnfr1 (9, 10, 11, 12)." ], "offsets": [ [ 0, 248 ] ] } ]
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[]
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1.0alpha7.train.150
19263710
[ { "id": "1.0alpha7.train.150.sent", "type": "sentence", "text": [ "Studies in vitro revealed that both p55 and hDlg bind directly to protein 4.1 [7 ." ], "offsets": [ [ 0, 82 ] ] } ]
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[]
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1.0alpha7.train.151
9838417
[ { "id": "1.0alpha7.train.151.sent", "type": "sentence", "text": [ "Consistent with previous work, Y-27632 treatment in SDF-1alpha - stimulated neurons was sufficient to increase the GTP-bound form of Rac ( Fig. 9 B)." ], "offsets": [ [ 0, 149 ] ] } ]
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[]
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1.0alpha7.train.152
19831892
[ { "id": "1.0alpha7.train.152.sent", "type": "sentence", "text": [ "The underlined grey box represents the region involved in the binding of the ADP moiety of FAD." ], "offsets": [ [ 0, 95 ] ] } ]
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[]
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[]
1.0alpha7.train.153
1810603
[ { "id": "1.0alpha7.train.153.sent", "type": "sentence", "text": [ "In a similar study, Schowalter et al. (15) showed that three separate regions of the progesterone receptor HBD could confer hsp90 binding when fused to a mutant PR lacking the HBD." ], "offsets": [ [ 0, 180 ] ] } ]
[ { "id": "1.0alpha7.train.153.ent0_0", "type": "protein", "text": [ "PR" ], "offsets": [ [ 161, 163 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5241" }, { "db_name": "hgnc", "db_id": "PGR" }, { "db_name": "uniprot", "db_id": "P06401" } ] }, { "id": "1.0alpha7.train.153.ent1_0", "type": "protein", "text": [ "progesterone receptor" ], "offsets": [ [ 85, 106 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5241" }, { "db_name": "hgnc", "db_id": "PGR" }, { "db_name": "uniprot", "db_id": "P06401" } ] }, { "id": "1.0alpha7.train.153.ent2_0", "type": "protein-domain", "text": [ "HBD" ], "offsets": [ [ 107, 110 ] ], "normalized": [] }, { "id": "1.0alpha7.train.153.ent3_1", "type": "protein-domain", "text": [ "HBD" ], "offsets": [ [ 176, 179 ] ], "normalized": [] }, { "id": "1.0alpha7.train.153.ent4_0", "type": "protein", "text": [ "mutant PR" ], "offsets": [ [ 154, 163 ] ], "normalized": [] }, { "id": "1.0alpha7.train.153.ent5_0", "type": "protein", "text": [ "hsp90" ], "offsets": [ [ 124, 129 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3320" }, { "db_name": "hgnc", "db_id": "HSP90AA1" }, { "db_name": "uniprot", "db_id": "P07900" } ] } ]
[]
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1.0alpha7.train.154
18018466
[ { "id": "1.0alpha7.train.154.sent", "type": "sentence", "text": [ "Chen et al. (2001) recently demonstrated that TNF-alpha induces acetylation of p65 by p300/CBP, thus abrogating the binding of p65 to IkappaBalpha." ], "offsets": [ [ 0, 147 ] ] } ]
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[]
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1.0alpha7.train.155
3232148
[ { "id": "1.0alpha7.train.155.sent", "type": "sentence", "text": [ "A difference in the NAD+/NADH binding properties of dI in its isolated form and in the complete, membrane-bound protein was also inferred from a steady-state kinetic analysis (7). " ], "offsets": [ [ 0, 180 ] ] } ]
[ { "id": "1.0alpha7.train.155.ent0_0", "type": "chemical", "text": [ "NAD+" ], "offsets": [ [ 20, 24 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "925" } ] }, { "id": "1.0alpha7.train.155.ent1_0", "type": "chemical", "text": [ "NADH" ], "offsets": [ [ 25, 29 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "439153" } ] }, { "id": "1.0alpha7.train.155.ent2_0", "type": "protein-domain", "text": [ "dI" ], "offsets": [ [ 52, 54 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.156
9524636
[ { "id": "1.0alpha7.train.156.sent", "type": "sentence", "text": [ "EGF-like rpts, epidermal growth factor-like repeats; L/N rpts, Lin12/Notch repeats; CDC, CDC10/Ankyrin repeats; OPA, Glutamine-rich sequence; Dab, Disabled; Dx, Deltex; Dsh, Dishevelled; H, Hairless (exact binding site is not known)." ], "offsets": [ [ 0, 233 ] ] } ]
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[]
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[]
1.0alpha7.train.157
883977
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[]
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1.0alpha7.train.158
5052631
[ { "id": "1.0alpha7.train.158.sent", "type": "sentence", "text": [ "DNase I footprinting assays showed that the interaction prevents binding of Sp1 to the GC boxes of the ADH5/ FDH promoter." ], "offsets": [ [ 0, 122 ] ] } ]
[ { "id": "1.0alpha7.train.158.ent0_0", "type": "protein", "text": [ "DNase I" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1773" }, { "db_name": "hgnc", "db_id": "DNASE1" }, { "db_name": "uniprot", "db_id": "P24855" } ] }, { "id": "1.0alpha7.train.158.ent1_0", "type": "gene", "text": [ "FDH" ], "offsets": [ [ 109, 112 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "128" }, { "db_name": "hgnc", "db_id": "ADH5" } ] }, { "id": "1.0alpha7.train.158.ent2_0", "type": "gene", "text": [ "ADH5" ], "offsets": [ [ 103, 107 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "128" }, { "db_name": "hgnc", "db_id": "ADH5" } ] }, { "id": "1.0alpha7.train.158.ent3_0", "type": "DNA", "text": [ "ADH5/ FDH promoter" ], "offsets": [ [ 103, 121 ] ], "normalized": [] }, { "id": "1.0alpha7.train.158.ent4_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 76, 79 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] }, { "id": "1.0alpha7.train.158.ent5_0", "type": "DNA", "text": [ "GC boxes" ], "offsets": [ [ 87, 95 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.159
6757035
[ { "id": "1.0alpha7.train.159.sent", "type": "sentence", "text": [ "We suggest that, without p35, Cdk5 is bound and activated by Pho85 cyclins, which then direct Cdk5 to Pho85 substrates, allowing functional complementation of the pho85delta strain." ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "1.0alpha7.train.159.ent0_0", "type": "protein", "text": [ "pho85delta" ], "offsets": [ [ 163, 173 ] ], "normalized": [] }, { "id": "1.0alpha7.train.159.ent1_0", "type": "protein", "text": [ "Pho85" ], "offsets": [ [ 61, 66 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P17157" } ] }, { "id": "1.0alpha7.train.159.ent2_1", "type": "protein", "text": [ "Pho85" ], "offsets": [ [ 102, 107 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "P17157" } ] }, { "id": "1.0alpha7.train.159.ent3_0", "type": "protein-family", "text": [ "Pho85 cyclins" ], "offsets": [ [ 61, 74 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR012104" } ] }, { "id": "1.0alpha7.train.159.ent4_0", "type": "protein", "text": [ "Cdk5" ], "offsets": [ [ 30, 34 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1020" }, { "db_name": "hgnc", "db_id": "CDK5" }, { "db_name": "uniprot", "db_id": "Q00535" } ] }, { "id": "1.0alpha7.train.159.ent5_1", "type": "protein", "text": [ "Cdk5" ], "offsets": [ [ 94, 98 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1020" }, { "db_name": "hgnc", "db_id": "CDK5" }, { "db_name": "uniprot", "db_id": "Q00535" } ] }, { "id": "1.0alpha7.train.159.ent6_0", "type": "protein", "text": [ "p35" ], "offsets": [ [ 25, 28 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8851" }, { "db_name": "hgnc", "db_id": "CDK5R1" }, { "db_name": "uniprot", "db_id": "Q15078" } ] } ]
[]
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[ { "id": "1.0alpha7.train.159.rel0s1.0alpha7.train.159.ent3_0.o1.0alpha7.train.159.ent4_0", "type": "bind", "arg1_id": "1.0alpha7.train.159.ent3_0", "arg2_id": "1.0alpha7.train.159.ent4_0", "normalized": [] }, { "id": "1.0alpha7.train.159.rel0s1.0alpha7.train.159.ent3_0.o1.0alpha7.train.159.ent5_1", "type": "bind", "arg1_id": "1.0alpha7.train.159.ent3_0", "arg2_id": "1.0alpha7.train.159.ent5_1", "normalized": [] } ]
1.0alpha7.train.160
21938299
[ { "id": "1.0alpha7.train.160.sent", "type": "sentence", "text": [ "On the other hand, 13 genes (Alpha-tubulin, Swiprosin-2, Insulin-like growth factor binding protein 2 [IGFBP2], CRBP, Apo D, NU, Claudin-3, Uncoupling protein-2 [UCP-2], CRIP-1, MT 1G, Apolipoprotein CI [Apo CI], CLF-1, Transglutaminase-2) retained high cytosine content in their CpG islands or CpG sites deemed critical for transcription (Apo D) after bisulfite treatment, indicating heavy cytosine methylation (Figures 3A and 3B)." ], "offsets": [ [ 0, 432 ] ] } ]
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[]
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[]
1.0alpha7.train.161
9202451
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[]
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1.0alpha7.train.162
25368349
[ { "id": "1.0alpha7.train.162.sent", "type": "sentence", "text": [ "Genetic mutants lacking adenylyl cyclase, cAMP-dependent protein kinase (PKA), or cAMP response element ( CRE) binding protein (CREB) exhibit significant defects in different forms of behavioral learning and memory (Livingston et al., 1984 ; Foster et al." ], "offsets": [ [ 0, 255 ] ] } ]
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[]
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1.0alpha7.train.163
15178699
[ { "id": "1.0alpha7.train.163.sent", "type": "sentence", "text": [ "Apart from nonimmune controls, we studied the c-jun promoter and found no binding of p300 and SAF-A to this site." ], "offsets": [ [ 0, 113 ] ] } ]
[ { "id": "1.0alpha7.train.163.ent0_0", "type": "protein", "text": [ "SAF-A" ], "offsets": [ [ 94, 99 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "3192" }, { "db_name": "hgnc", "db_id": "HNRNPU" }, { "db_name": "uniprot", "db_id": "Q00839" } ] }, { "id": "1.0alpha7.train.163.ent1_0", "type": "DNA", "text": [ "c-jun promoter" ], "offsets": [ [ 46, 60 ] ], "normalized": [] }, { "id": "1.0alpha7.train.163.ent2_0", "type": "protein", "text": [ "p300" ], "offsets": [ [ 85, 89 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "2033" }, { "db_name": "hgnc", "db_id": "EP300" }, { "db_name": "uniprot", "db_id": "Q09472" } ] } ]
[]
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1.0alpha7.train.164
5429201
[ { "id": "1.0alpha7.train.164.sent", "type": "sentence", "text": [ "However, both assays revealed that double mutation of these residues to alanine abrogated binding of mSTI1 to Hsc70." ], "offsets": [ [ 0, 116 ] ] } ]
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[]
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1.0alpha7.train.165
6201453
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[]
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[]
1.0alpha7.train.166
16569943
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[]
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1.0alpha7.train.167
12533848
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[]
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1.0alpha7.train.168
13041757
[ { "id": "1.0alpha7.train.168.sent", "type": "sentence", "text": [ "Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis." ], "offsets": [ [ 0, 122 ] ] } ]
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[]
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1.0alpha7.train.169
3796587
[ { "id": "1.0alpha7.train.169.sent", "type": "sentence", "text": [ "In support of this hypothesis, PU.1 binding to the μB site is undetectable in EMSA analyses of B cell nuclear extracts despite the demonstrations that 1) DNA-binding PU.1 is present in B cell nuclei and 2) recombinant PU.1 binds the μB site in a variety of analyses (3, 25, 41)." ], "offsets": [ [ 0, 278 ] ] } ]
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[]
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1.0alpha7.train.170
19694236
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[]
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1.0alpha7.train.171
11817587
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1.0alpha7.train.172
25227450
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[]
1.0alpha7.train.173
2068117
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[]
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1.0alpha7.train.174
9541858
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[]
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1.0alpha7.train.175
7486370
[ { "id": "1.0alpha7.train.175.sent", "type": "sentence", "text": [ "In complex with the drug FK506, FKBP12 binds calcineurin, inhibiting calcineurin's phosphatase activity and thus its ability to activate the transcription factor NF-AT in the T-cell receptor signal transduction pathway ( 170)." ], "offsets": [ [ 0, 226 ] ] } ]
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[]
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1.0alpha7.train.176
1696385
[ { "id": "1.0alpha7.train.176.sent", "type": "sentence", "text": [ "CREB phosphorylation enhances CREB binding to CREB-binding protein, thus activating gene transcription via the CRE ( 29)." ], "offsets": [ [ 0, 121 ] ] } ]
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[]
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1.0alpha7.train.177
9608928
[ { "id": "1.0alpha7.train.177.sent", "type": "sentence", "text": [ "Still other mechanisms are likely to be highly receptor-specific: the binding of NHERF to the β2-adrenergic receptor and the binding of Homer to metabotropic glutamate receptors, for example, depend on the presence of precise motifs that are likely to be found in few other heptahelical receptors, although other receptors are likely to contain slightly modified motifs that mediate binding to other specific PDZ or polyproline-binding domains." ], "offsets": [ [ 0, 444 ] ] } ]
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[]
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1.0alpha7.train.178
6906183
[ { "id": "1.0alpha7.train.178.sent", "type": "sentence", "text": [ "( A) U1 snRNP binds to the dsx pre-mRNA independently of the ESE, whereas the ESE and U1 snRNP are required for the assembly of U2, U4/U6, and U5 snRNPs on the dsx pre-mRNA." ], "offsets": [ [ 0, 173 ] ] } ]
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[]
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1.0alpha7.train.179
16348415
[ { "id": "1.0alpha7.train.179.sent", "type": "sentence", "text": [ "First, p21 binds PCNA ( 15) through a region found by Chuang et al. to be similar to, and to compete with, the site in DNA-MCMT that mediates PCNA binding." ], "offsets": [ [ 0, 155 ] ] } ]
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[]
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1.0alpha7.train.180
11991611
[ { "id": "1.0alpha7.train.180.sent", "type": "sentence", "text": [ "As shown in Figure ​7A (panels labeled ‘GAL4’), GAL4 WT, DB·CR and DB·AD bound more readily than the DNA-binding domain alone to an artificial promoter, which bears four GAL4 sites fused to an unrelated HIS4 basal promoter." ], "offsets": [ [ 0, 223 ] ] } ]
[ { "id": "1.0alpha7.train.180.ent0_0", "type": "protein-region", "text": [ "DB·AD" ], "offsets": [ [ 67, 72 ] ], "normalized": [] }, { "id": "1.0alpha7.train.180.ent1_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 101, 104 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.180.ent2_0", "type": "DNA", "text": [ "GAL4 sites" ], "offsets": [ [ 170, 180 ] ], "normalized": [] }, { "id": "1.0alpha7.train.180.ent3_0", "type": "protein-domain", "text": [ "DNA-binding domain" ], "offsets": [ [ 101, 119 ] ], "normalized": [] }, { "id": "1.0alpha7.train.180.ent4_0", "type": "protein-region", "text": [ "GAL4 WT" ], "offsets": [ [ 48, 55 ] ], "normalized": [] }, { "id": "1.0alpha7.train.180.ent5_0", "type": "protein-region", "text": [ "DB·CR" ], "offsets": [ [ 57, 62 ] ], "normalized": [] }, { "id": "1.0alpha7.train.180.ent6_0", "type": "DNA", "text": [ "HIS4 basal promoter" ], "offsets": [ [ 203, 222 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.181
9426278
[ { "id": "1.0alpha7.train.181.sent", "type": "sentence", "text": [ "The cytoplasmic domain of the cadherin can bind directly to p120ctn as well as beta-catenin, and either protein could play a role in growth suppression." ], "offsets": [ [ 0, 152 ] ] } ]
[ { "id": "1.0alpha7.train.181.ent0_0", "type": "protein-family", "text": [ "cadherin" ], "offsets": [ [ 30, 38 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR039808" } ] }, { "id": "1.0alpha7.train.181.ent1_0", "type": "protein", "text": [ "beta-catenin" ], "offsets": [ [ 79, 91 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1499" }, { "db_name": "hgnc", "db_id": "CTNNB1" }, { "db_name": "uniprot", "db_id": "P35222" } ] }, { "id": "1.0alpha7.train.181.ent2_0", "type": "protein-domain", "text": [ "cytoplasmic domain" ], "offsets": [ [ 4, 22 ] ], "normalized": [] }, { "id": "1.0alpha7.train.181.ent3_0", "type": "protein", "text": [ "p120ctn" ], "offsets": [ [ 60, 67 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1500" }, { "db_name": "hgnc", "db_id": "CTNND1" }, { "db_name": "uniprot", "db_id": "O60716" } ] } ]
[]
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1.0alpha7.train.182
19533945
[ { "id": "1.0alpha7.train.182.sent", "type": "sentence", "text": [ "As a consequence, Armadillo is no longer bound by Axin, resulting in nuclear signaling by Armadillo." ], "offsets": [ [ 0, 100 ] ] } ]
[ { "id": "1.0alpha7.train.182.ent0_0", "type": "protein", "text": [ "Axin" ], "offsets": [ [ 50, 54 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "8312" }, { "db_name": "hgnc", "db_id": "AXIN1" }, { "db_name": "uniprot", "db_id": "O15169" } ] }, { "id": "1.0alpha7.train.182.ent1_0", "type": "protein-motif", "text": [ "Armadillo" ], "offsets": [ [ 18, 27 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000225" } ] }, { "id": "1.0alpha7.train.182.ent2_1", "type": "protein-motif", "text": [ "Armadillo" ], "offsets": [ [ 90, 99 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR000225" } ] } ]
[]
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1.0alpha7.train.183
53656
[ { "id": "1.0alpha7.train.183.sent", "type": "sentence", "text": [ "Assay for CD22Rg Binding to HEC After washing with Medium 199, HEC were incubated with 2.5 mug/ ml CD22 mRg in Medium 199, 1% BSA at 4 degrees C for 2 h, in the absence or presence of alpha2-6-sLac or alpha2-3-sLac, plasma, IgM, haptoglobin, or IgG." ], "offsets": [ [ 0, 249 ] ] } ]
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[]
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[]
1.0alpha7.train.184
3650301
[ { "id": "1.0alpha7.train.184.sent", "type": "sentence", "text": [ "Moreover, it has been found that acetyl-CoA can enhance the transcription of naked DNA (greater than 5-fold) as well as the binding of TFIID to promoter DNA in the absence of histones ( 35)." ], "offsets": [ [ 0, 190 ] ] } ]
[ { "id": "1.0alpha7.train.184.ent0_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 83, 86 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.184.ent1_1", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 153, 156 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "25782" }, { "db_name": "hgnc", "db_id": "RAB3GAP2" }, { "db_name": "uniprot", "db_id": "Q9H2M9" } ] }, { "id": "1.0alpha7.train.184.ent2_0", "type": "protein", "text": [ "TFIID" ], "offsets": [ [ 135, 140 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6908" }, { "db_name": "hgnc", "db_id": "TBP" }, { "db_name": "uniprot", "db_id": "P20226" } ] }, { "id": "1.0alpha7.train.184.ent3_0", "type": "chemical", "text": [ "acetyl-CoA" ], "offsets": [ [ 33, 43 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "444493" } ] } ]
[]
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1.0alpha7.train.185
2941370
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1.0alpha7.train.186
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1.0alpha7.train.187
15528171
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1.0alpha7.train.188
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1.0alpha7.train.189
19483256
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1.0alpha7.train.190
6233612
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1.0alpha7.train.191
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[]
1.0alpha7.train.192
15894566
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1.0alpha7.train.193
15990177
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1.0alpha7.train.194
20679901
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1.0alpha7.train.195
15727450
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1.0alpha7.train.196
9032293
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1.0alpha7.train.197
9083350
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1.0alpha7.train.198
11052504
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[]
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1.0alpha7.train.199
19808375
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