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1.0alpha7.train.300
3654233
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[]
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1.0alpha7.train.301
20457160
[ { "id": "1.0alpha7.train.301.sent", "type": "sentence", "text": [ "By extension of studies of the Rad3 ATPase (15), mutation of the conserved lysine residue in the Walker domain to alanine (K→A) in Rad54 is thought to prevent ATP binding, whereas mutation of lysine to arginine (K→R) is expected to prevent ATP hydrolysis but not ATP binding." ], "offsets": [ [ 0, 275 ] ] } ]
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[]
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1.0alpha7.train.302
15776300
[ { "id": "1.0alpha7.train.302.sent", "type": "sentence", "text": [ " Note that cyclin E binds to both forms of Cdk2, whereas cyclin A binds only the activated form of Cdk2. " ], "offsets": [ [ 0, 110 ] ] } ]
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[]
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1.0alpha7.train.303
1810686
[ { "id": "1.0alpha7.train.303.sent", "type": "sentence", "text": [ "Binding of GST537C and GST547C to hsp90 after their translation in reticulocyte lysate." ], "offsets": [ [ 0, 90 ] ] } ]
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1.0alpha7.train.304
18797540
[ { "id": "1.0alpha7.train.304.sent", "type": "sentence", "text": [ " Thus, for example, Hairy binds dCtBP strongly but hCtBP weakly, confirming the specificity of the binding sites. " ], "offsets": [ [ 0, 117 ] ] } ]
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[]
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1.0alpha7.train.305
1929398
[ { "id": "1.0alpha7.train.305.sent", "type": "sentence", "text": [ " To ascertain the binding affinity of Pitx2 for the bicoid element, an EMSA DNA titration experiment was performed. " ], "offsets": [ [ 0, 126 ] ] } ]
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[]
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1.0alpha7.train.306
11059909
[ { "id": "1.0alpha7.train.306.sent", "type": "sentence", "text": [ "Axin binds to not only GSK3 and DCAP but also Arrow/LRP5." ], "offsets": [ [ 0, 57 ] ] } ]
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1.0alpha7.train.307
13021306
[ { "id": "1.0alpha7.train.307.sent", "type": "sentence", "text": [ " W EN et al. 1995 ; P OTEET-SMITH et al. 1997 ), we conclude that PKAr* must bind PKAc to activate Hh target genes. " ], "offsets": [ [ 0, 127 ] ] } ]
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1.0alpha7.train.308
24638134
[ { "id": "1.0alpha7.train.308.sent", "type": "sentence", "text": [ "The CtBP structure reveals a bound acetate ion (right panel)." ], "offsets": [ [ 0, 62 ] ] } ]
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1.0alpha7.train.309
20295885
[ { "id": "1.0alpha7.train.309.sent", "type": "sentence", "text": [ " We propose that this is where CstF-64 binds to CstF-77, and this is supported by in vitro experiments with the human protein (Y.Takagaki and J.L.Manley, submitted). " ], "offsets": [ [ 0, 171 ] ] } ]
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[]
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1.0alpha7.train.310
14471508
[ { "id": "1.0alpha7.train.310.sent", "type": "sentence", "text": [ " From these results, we can reasonably conclude that IntI1 bound both ds and ss attI but that only ss attC was efficiently bound by IntI1 in vitro. " ], "offsets": [ [ 0, 151 ] ] } ]
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[]
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1.0alpha7.train.311
4519188
[ { "id": "1.0alpha7.train.311.sent", "type": "sentence", "text": [ "Our observation that binding of eIF4A to eIF4G is cooperative could explain these results by ensuring a higher affinity interaction between eIF4G and eIF4A." ], "offsets": [ [ 0, 160 ] ] } ]
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[]
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1.0alpha7.train.312
18356833
[ { "id": "1.0alpha7.train.312.sent", "type": "sentence", "text": [ "This inhibition is mediated through the Pnt domain-dependent binding of Mae to Yan (compare lanes 7 and 10)." ], "offsets": [ [ 0, 111 ] ] } ]
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[]
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1.0alpha7.train.313
15500140
[ { "id": "1.0alpha7.train.313.sent", "type": "sentence", "text": [ " However, it remained to be shown whether Aos binds directly to DER. " ], "offsets": [ [ 0, 72 ] ] } ]
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[]
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1.0alpha7.train.314
8951536
[ { "id": "1.0alpha7.train.314.sent", "type": "sentence", "text": [ " Deletion mutagenesis also indicated that Leu-20, Phe-25, and Glu-70 in dTAFII230 are important for TBP binding and inhibition of TBP-promoter interaction. " ], "offsets": [ [ 0, 163 ] ] } ]
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[]
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1.0alpha7.train.315
15791822
[ { "id": "1.0alpha7.train.315.sent", "type": "sentence", "text": [ "That occupation of the ATP/ADP binding pocket of Hsp90 by GA results in dissociation of the protein from Raf-1 is consistent with the notion that alternating cycles of ATP and ADP binding regulate Hsp90 conformation and, in turn, its ability to mediate the formation of productive signaling heterocomplexes (7, 22, 55, 72)." ], "offsets": [ [ 0, 323 ] ] } ]
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[]
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1.0alpha7.train.316
24614174
[ { "id": "1.0alpha7.train.316.sent", "type": "sentence", "text": [ "Despite the higher abundance of PTBΔ in the IP pellet (Figure 6B, compare lane 12 to lane 10), no binding of PTBΔ to MSE1-4 RNA could be detected by UV crosslinking, while binding of PTB was clearly and consistently detected (Figure 6B, compare lanes 4 and 6)." ], "offsets": [ [ 0, 260 ] ] } ]
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[]
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1.0alpha7.train.317
16308908
[ { "id": "1.0alpha7.train.317.sent", "type": "sentence", "text": [ "The behavior in the motility assay suggested that AS-2 may interfere with MT binding to kinesin." ], "offsets": [ [ 0, 98 ] ] } ]
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[]
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1.0alpha7.train.318
11347530
[ { "id": "1.0alpha7.train.318.sent", "type": "sentence", "text": [ " It should be noted that importin alpha binding was strictly dependent on the presence of importin beta (not shown), as if the importin alpha/ beta heterodimer would bind rpL23a only via the beta subunit. " ], "offsets": [ [ 0, 211 ] ] } ]
[ { "id": "1.0alpha7.train.318.ent0_0", "type": "protein-family", "text": [ "importin alpha" ], "offsets": [ [ 26, 40 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR040122" } ] }, { "id": "1.0alpha7.train.318.ent1_1", "type": "protein-family", "text": [ "importin alpha" ], "offsets": [ [ 130, 144 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR040122" } ] }, { "id": "1.0alpha7.train.318.ent2_0", "type": "protein-complex", "text": [ "importin alpha/ beta" ], "offsets": [ [ 130, 150 ] ], "normalized": [] }, { "id": "1.0alpha7.train.318.ent3_0", "type": "protein-family", "text": [ "importin beta" ], "offsets": [ [ 92, 105 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR040122" } ] }, { "id": "1.0alpha7.train.318.ent4_0", "type": "protein", "text": [ "rpL23a" ], "offsets": [ [ 175, 181 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6147" }, { "db_name": "hgnc", "db_id": "RPL23A" }, { "db_name": "uniprot", "db_id": "P62750" } ] } ]
[]
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1.0alpha7.train.319
9149598
[ { "id": "1.0alpha7.train.319.sent", "type": "sentence", "text": [ " When HH binds to Ptc, Smo accumulates in the membrane in a highly phosphorylated state and HH targets are activated. " ], "offsets": [ [ 0, 126 ] ] } ]
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[]
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1.0alpha7.train.320
1749030
[ { "id": "1.0alpha7.train.320.sent", "type": "sentence", "text": [ " Both Hsp70 and Hsp88 bound to Hsp30 in preference to other proteins, but binding of Hsp88 was more selective for Hsp30, and a direct interaction was observed. " ], "offsets": [ [ 0, 166 ] ] } ]
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[]
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1.0alpha7.train.321
15788776
[ { "id": "1.0alpha7.train.321.sent", "type": "sentence", "text": [ " CBP and p300 bind many other transcription factors, including p53, NF-kappaB p65, and RAR, and the association with CBP has been shown to correlate with transcription activation function ( 26, 30, 43, 53, 71). " ], "offsets": [ [ 0, 222 ] ] } ]
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[]
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1.0alpha7.train.322
19992155
[ { "id": "1.0alpha7.train.322.sent", "type": "sentence", "text": [ "DREF binds to the DRE sequences in the Dm myb promoter" ], "offsets": [ [ 0, 54 ] ] } ]
[ { "id": "1.0alpha7.train.322.ent0_0", "type": "DNA", "text": [ "DRE sequences" ], "offsets": [ [ 18, 31 ] ], "normalized": [] }, { "id": "1.0alpha7.train.322.ent1_0", "type": "DNA", "text": [ "Dm myb promoter" ], "offsets": [ [ 39, 54 ] ], "normalized": [] }, { "id": "1.0alpha7.train.322.ent2_0", "type": "protein", "text": [ "DREF" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "9189" }, { "db_name": "hgnc", "db_id": "ZBED1" }, { "db_name": "uniprot", "db_id": "O96006" } ] } ]
[]
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1.0alpha7.train.323
1559257
[ { "id": "1.0alpha7.train.323.sent", "type": "sentence", "text": [ " We have demonstrated that the N-terminal domain of MEKK1 binds directly to its downstream MAP kinase, JNK/SAPK. " ], "offsets": [ [ 0, 115 ] ] } ]
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[]
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1.0alpha7.train.324
762216
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[]
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1.0alpha7.train.325
2465578
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[]
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[]
1.0alpha7.train.326
24668031
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[]
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1.0alpha7.train.327
9541801
[ { "id": "1.0alpha7.train.327.sent", "type": "sentence", "text": [ " Therefore, Axin and GBP both bind to GSK-3, but have opposite effects on its activity. " ], "offsets": [ [ 0, 92 ] ] } ]
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[]
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1.0alpha7.train.328
15036857
[ { "id": "1.0alpha7.train.328.sent", "type": "sentence", "text": [ " As shown in Fig. 4D (lower panel), wt p53 showed strong binding to Sp1. " ], "offsets": [ [ 0, 77 ] ] } ]
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[]
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1.0alpha7.train.329
15768212
[ { "id": "1.0alpha7.train.329.sent", "type": "sentence", "text": [ " Again, we noted that Ets-1(delta286) bound to both GST and GST-USF, which indicated nonspecific interactions. " ], "offsets": [ [ 0, 115 ] ] } ]
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[]
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1.0alpha7.train.330
9401270
[ { "id": "1.0alpha7.train.330.sent", "type": "sentence", "text": [ " In this study, we tested the hypothesis that Ena/VASP recruitment by the central domain of ActA functions redundantly with the actin monomer-binding region of ActA to stimulate actin polymerization. " ], "offsets": [ [ 0, 209 ] ] } ]
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[]
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1.0alpha7.train.331
8467741
[ { "id": "1.0alpha7.train.331.sent", "type": "sentence", "text": [ "We have previously shown that two E-boxes in the SM α-actin promoter at -214 bp (E1) and -252 bp (E2) functioned as positive regulatory elements in cultured SMCs and that USF proteins, ubiquitously expressed bHLH-leucine zipper transcription factors, activated the SM α-actin promoter in an E1-dependent (but not E2-dependent) manner." ], "offsets": [ [ 0, 334 ] ] } ]
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[]
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1.0alpha7.train.332
19102273
[ { "id": "1.0alpha7.train.332.sent", "type": "sentence", "text": [ "From the effect of mutation of R. rubrum Y235 and M239 located in this segment [69], [70], [72], they proposed that the loop closure would be important for positioning the nicotinamide ring but would be involved neither in discrimination between NADH and NAD+ nor in the binding of dI to dIII." ], "offsets": [ [ 0, 293 ] ] } ]
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[]
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1.0alpha7.train.333
11880697
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[]
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1.0alpha7.train.334
9641340
[ { "id": "1.0alpha7.train.334.sent", "type": "sentence", "text": [ "To determine if this was the case, we produced a recombinant mutant of cyclin B1 previously reported to lack the ability to interact with Cdc2 (cyclin B1 121-373; Stewart et al., 1994) and an analogous mutant of cyclin E unable to bind Cdk2 (cyclin E 1-338; Fig. ​Fig.55 A). " ], "offsets": [ [ 0, 275 ] ] } ]
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[]
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1.0alpha7.train.335
4884022
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[]
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1.0alpha7.train.336
4050199
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[]
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1.0alpha7.train.337
225487
[ { "id": "1.0alpha7.train.337.sent", "type": "sentence", "text": [ " Adducin has been seen to promote the binding of spectrin to F-actin (5, Fig.9 A). " ], "offsets": [ [ 0, 88 ] ] } ]
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[]
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1.0alpha7.train.338
5443867
[ { "id": "1.0alpha7.train.338.sent", "type": "sentence", "text": [ "ICAP-1alpha competes with talin but not with alpha-actinin binding to the beta1 cytoplasmic domain." ], "offsets": [ [ 0, 102 ] ] } ]
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[]
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[]
1.0alpha7.train.339
6265431
[ { "id": "1.0alpha7.train.339.sent", "type": "sentence", "text": [ "( B) Deletion of the p300-binding region of SRC-1 abolished the interaction between p300 and SRC-1." ], "offsets": [ [ 0, 103 ] ] } ]
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[]
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1.0alpha7.train.340
4585296
[ { "id": "1.0alpha7.train.340.sent", "type": "sentence", "text": [ " However, the binding affinity of MKP3 with ERK2 decreases 16-fold when both Leu167 and Leu170 are replaced by Ala residues. " ], "offsets": [ [ 0, 129 ] ] } ]
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[]
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1.0alpha7.train.341
38544
[ { "id": "1.0alpha7.train.341.sent", "type": "sentence", "text": [ " However, the present findings suggest that such a simple model is probably not correct and provide strong evidence that the binding of CBP to CREB is not sufficient for transcriptional activation. " ], "offsets": [ [ 0, 204 ] ] } ]
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[]
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1.0alpha7.train.342
9170179
[ { "id": "1.0alpha7.train.342.sent", "type": "sentence", "text": [ "(C) Differential binding of recombinant s-synaphin constructs to syntaxin." ], "offsets": [ [ 0, 76 ] ] } ]
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[]
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1.0alpha7.train.343
3506574
[ { "id": "1.0alpha7.train.343.sent", "type": "sentence", "text": [ " PP2A binds to Axin ( 22, 30), and it dephosphorylates APC and Axin ( 22). " ], "offsets": [ [ 0, 80 ] ] } ]
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[]
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1.0alpha7.train.344
285199
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1.0alpha7.train.345
12692946
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1.0alpha7.train.346
9843494
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1.0alpha7.train.347
6656120
[ { "id": "1.0alpha7.train.347.sent", "type": "sentence", "text": [ "The results confirmed that ATP bound to KaiC and CI but failed to associate with CII (Fig. 2 E and data not shown)." ], "offsets": [ [ 0, 120 ] ] } ]
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1.0alpha7.train.348
38547
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1.0alpha7.train.349
54804
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[]
1.0alpha7.train.350
2873562
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1.0alpha7.train.351
7465567
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1.0alpha7.train.352
1266444
[ { "id": "1.0alpha7.train.352.sent", "type": "sentence", "text": [ " Following probing with the anti-wheat PABP antibodies, PABP was detected bound to eIF-4B, eIF-4F, eIF-iso4F, and recombinant eIF-iso4G, but not to eIF-iso4E or eIF-4A (Fig. 2 A). " ], "offsets": [ [ 0, 190 ] ] } ]
[ { "id": "1.0alpha7.train.352.ent0_0", "type": "protein", "text": [ "PABP" ], "offsets": [ [ 40, 44 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "26986" }, { "db_name": "hgnc", "db_id": "PABPC1" }, { "db_name": "uniprot", "db_id": "P11940" } ] }, { "id": "1.0alpha7.train.352.ent1_1", "type": "protein", "text": [ "PABP" ], "offsets": [ [ 58, 62 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "26986" }, { "db_name": "hgnc", "db_id": "PABPC1" }, { "db_name": "uniprot", "db_id": "P11940" } ] }, { "id": "1.0alpha7.train.352.ent2_0", "type": "protein", "text": [ "eIF-4B" ], "offsets": [ [ 86, 92 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1975" }, { "db_name": "hgnc", "db_id": "EIF4B" }, { "db_name": "uniprot", "db_id": "P23588" } ] }, { "id": "1.0alpha7.train.352.ent3_0", "type": "protein", "text": [ "eIF-4A" ], "offsets": [ [ 169, 175 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "Q93ZT6" } ] }, { "id": "1.0alpha7.train.352.ent4_0", "type": "protein-complex", "text": [ "eIF-4F" ], "offsets": [ [ 95, 101 ] ], "normalized": [] }, { "id": "1.0alpha7.train.352.ent5_0", "type": "protein", "text": [ "eIF-iso4E" ], "offsets": [ [ 155, 164 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O04663" } ] }, { "id": "1.0alpha7.train.352.ent6_0", "type": "reagent", "text": [ "PABP antibodies" ], "offsets": [ [ 40, 55 ] ], "normalized": [] }, { "id": "1.0alpha7.train.352.ent7_0", "type": "protein-complex", "text": [ "eIF-iso4F" ], "offsets": [ [ 104, 113 ] ], "normalized": [] }, { "id": "1.0alpha7.train.352.ent8_0", "type": "protein", "text": [ "eIF-iso4G" ], "offsets": [ [ 132, 141 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "O04663" } ] } ]
[]
[ { "id": "1.0alpha7.train.352.coref0", "entity_ids": [ "1.0alpha7.train.352.ent0_0", "1.0alpha7.train.352.ent1_1" ] }, { "id": "1.0alpha7.train.352.coref1", "entity_ids": [ "1.0alpha7.train.352.ent2_0" ] }, { "id": "1.0alpha7.train.352.coref2", "entity_ids": [ "1.0alpha7.train.352.ent3_0" ] }, { "id": "1.0alpha7.train.352.coref3", "entity_ids": [ "1.0alpha7.train.352.ent4_0" ] }, { "id": "1.0alpha7.train.352.coref4", "entity_ids": [ "1.0alpha7.train.352.ent5_0" ] }, { "id": "1.0alpha7.train.352.coref5", "entity_ids": [ "1.0alpha7.train.352.ent6_0" ] }, { "id": "1.0alpha7.train.352.coref6", "entity_ids": [ "1.0alpha7.train.352.ent7_0" ] }, { "id": "1.0alpha7.train.352.coref7", "entity_ids": [ "1.0alpha7.train.352.ent8_0" ] } ]
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1.0alpha7.train.353
4050089
[ { "id": "1.0alpha7.train.353.sent", "type": "sentence", "text": [ "CEB does not bind GTP." ], "offsets": [ [ 0, 23 ] ] } ]
[ { "id": "1.0alpha7.train.353.ent0_0", "type": "chemical", "text": [ "GTP" ], "offsets": [ [ 19, 22 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "135398633" } ] }, { "id": "1.0alpha7.train.353.ent1_0", "type": "protein", "text": [ "CEB" ], "offsets": [ [ 0, 3 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.354
1418578
[ { "id": "1.0alpha7.train.354.sent", "type": "sentence", "text": [ "The results of this study suggest that the third positive response element at bp 125 also binds Sp1." ], "offsets": [ [ 0, 103 ] ] } ]
[ { "id": "1.0alpha7.train.354.ent0_0", "type": "protein", "text": [ "Sp1" ], "offsets": [ [ 99, 102 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "6667" }, { "db_name": "hgnc", "db_id": "SP1" }, { "db_name": "uniprot", "db_id": "P08047" } ] } ]
[]
[ { "id": "1.0alpha7.train.354.coref0", "entity_ids": [ "1.0alpha7.train.354.ent0_0" ] } ]
[]
1.0alpha7.train.355
11787607
[ { "id": "1.0alpha7.train.355.sent", "type": "sentence", "text": [ " Collectively, these findings indicate that cyt c and Hsp90 bind competitively to Apaf-1. " ], "offsets": [ [ 0, 93 ] ] } ]
[ { "id": "1.0alpha7.train.355.ent0_0", "type": "protein", "text": [ "cyt c" ], "offsets": [ [ 45, 50 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "54205" }, { "db_name": "hgnc", "db_id": "CYCS" }, { "db_name": "uniprot", "db_id": "P99999" } ] }, { "id": "1.0alpha7.train.355.ent1_0", "type": "protein-family", "text": [ "Hsp90" ], "offsets": [ [ 55, 60 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR001404" } ] }, { "id": "1.0alpha7.train.355.ent2_0", "type": "protein", "text": [ "Apaf-1" ], "offsets": [ [ 84, 90 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "317" }, { "db_name": "hgnc", "db_id": "APAF1" }, { "db_name": "uniprot", "db_id": "O14727" } ] } ]
[]
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1.0alpha7.train.356
15642343
[ { "id": "1.0alpha7.train.356.sent", "type": "sentence", "text": [ "Interestingly, CKIepsilon binds to mPER1 in a region that has no obvious sequence similarity to the suggested DBT-binding region of dPER (27)." ], "offsets": [ [ 0, 142 ] ] } ]
[ { "id": "1.0alpha7.train.356.ent0_0", "type": "protein", "text": [ "dPER" ], "offsets": [ [ 132, 136 ] ], "normalized": [ { "db_name": "uniprot", "db_id": "B4GYL6" } ] }, { "id": "1.0alpha7.train.356.ent1_0", "type": "protein", "text": [ "mPER1" ], "offsets": [ [ 35, 40 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5187" }, { "db_name": "hgnc", "db_id": "PER1" }, { "db_name": "uniprot", "db_id": "O15534" } ] }, { "id": "1.0alpha7.train.356.ent2_0", "type": "protein", "text": [ "CKIepsilon" ], "offsets": [ [ 15, 25 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1454" }, { "db_name": "hgnc", "db_id": "CSNK1E" }, { "db_name": "uniprot", "db_id": "P49674" } ] }, { "id": "1.0alpha7.train.356.ent3_0", "type": "protein", "text": [ "DBT" ], "offsets": [ [ 110, 113 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "1629" }, { "db_name": "hgnc", "db_id": "DBT" }, { "db_name": "uniprot", "db_id": "Q5VVL7" } ] } ]
[]
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1.0alpha7.train.357
1696390
[ { "id": "1.0alpha7.train.357.sent", "type": "sentence", "text": [ "Inhibiting CREB phosphorylation would thus inhibit CREB binding to CREB-binding protein and may inhibit TGF-beta-induced stimulation of fibronectin gene transcription." ], "offsets": [ [ 0, 171 ] ] } ]
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[]
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1.0alpha7.train.358
24079081
[ { "id": "1.0alpha7.train.358.sent", "type": "sentence", "text": [ " The pi- pi interactions between DMPP and aromatic residues of the AChR at positions 32, 33 and 151 may be important in slowing conformational changes triggered by DMPP binding, resulting in a slower beta. " ], "offsets": [ [ 0, 212 ] ] } ]
[ { "id": "1.0alpha7.train.358.ent0_0", "type": "chemical", "text": [ "DMPP" ], "offsets": [ [ 35, 39 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5911" } ] }, { "id": "1.0alpha7.train.358.ent1_1", "type": "chemical", "text": [ "DMPP" ], "offsets": [ [ 168, 172 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "5911" } ] }, { "id": "1.0alpha7.train.358.ent2_0", "type": "protein-family", "text": [ "AChR" ], "offsets": [ [ 70, 74 ] ], "normalized": [] } ]
[]
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1.0alpha7.train.359
88734
[ { "id": "1.0alpha7.train.359.sent", "type": "sentence", "text": [ " Binding of Rb to E2F, which represses E2F-dependent transcription, increases the half-life of E2F-DNA complexes 10-15-fold ( 58) . " ], "offsets": [ [ 0, 140 ] ] } ]
[ { "id": "1.0alpha7.train.359.ent0_0", "type": "protein-family", "text": [ "E2F" ], "offsets": [ [ 20, 23 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR015633" } ] }, { "id": "1.0alpha7.train.359.ent1_1", "type": "protein-family", "text": [ "E2F" ], "offsets": [ [ 42, 45 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR015633" } ] }, { "id": "1.0alpha7.train.359.ent2_2", "type": "protein-family", "text": [ "E2F" ], "offsets": [ [ 100, 103 ] ], "normalized": [ { "db_name": "interpro", "db_id": "IPR015633" } ] }, { "id": "1.0alpha7.train.359.ent3_0", "type": "DNA", "text": [ "DNA" ], "offsets": [ [ 104, 107 ] ], "normalized": [] }, { "id": "1.0alpha7.train.359.ent4_0", "type": "protein-complex", "text": [ "E2F-DNA" ], "offsets": [ [ 100, 107 ] ], "normalized": [] }, { "id": "1.0alpha7.train.359.ent5_0", "type": "protein", "text": [ "Rb" ], "offsets": [ [ 13, 15 ] ], "normalized": [ { "db_name": "NCBI gene", "db_id": "5925" }, { "db_name": "hgnc", "db_id": "RB1" }, { "db_name": "uniprot", "db_id": "P06400" } ] } ]
[]
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1.0alpha7.train.360
4249933
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[]
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1.0alpha7.train.361
11479130
[ { "id": "1.0alpha7.train.361.sent", "type": "sentence", "text": [ " Cell, 78, 761-771 [Medline] ubinfeld, B. , Albert, I. , Porfiri, E. , Fiol, C. , Munemitso, S. and Polakis, P. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. " ], "offsets": [ [ 0, 223 ] ] } ]
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[]
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1.0alpha7.train.362
795524
[ { "id": "1.0alpha7.train.362.sent", "type": "sentence", "text": [ " These results suggest that p62 binds noncovalently to ubiquitin, rather than forming a thioester or an isopeptide bond. " ], "offsets": [ [ 0, 124 ] ] } ]
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[]
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1.0alpha7.train.363
24638155
[ { "id": "1.0alpha7.train.363.sent", "type": "sentence", "text": [ "These data strongly imply that NAD+ binding to CtBP causes a conformational change necessary for binding of the PXDLS motif." ], "offsets": [ [ 0, 125 ] ] } ]
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[]
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1.0alpha7.train.364
5566793
[ { "id": "1.0alpha7.train.364.sent", "type": "sentence", "text": [ "Note that the LRR-to-EEE conversion altered the Rab binding specificity of Rim2." ], "offsets": [ [ 0, 83 ] ] } ]
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[]
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1.0alpha7.train.365
1712609
[ { "id": "1.0alpha7.train.365.sent", "type": "sentence", "text": [ "Binding of Numb PTB domain to LNX." ], "offsets": [ [ 0, 36 ] ] } ]
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[]
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1.0alpha7.train.366
25785588
[ { "id": "1.0alpha7.train.366.sent", "type": "sentence", "text": [ "We observed changes in the CRE-DNA binding of CREB after the ME ( Fig. 2B and E)." ], "offsets": [ [ 0, 84 ] ] } ]
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[]
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1.0alpha7.train.367
23431474
[ { "id": "1.0alpha7.train.367.sent", "type": "sentence", "text": [ " A neurobeachin isoform that does not bind RII, beige-like protein (BGL), is expressed in many tissues. " ], "offsets": [ [ 0, 107 ] ] } ]
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[]
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1.0alpha7.train.368
4287973
[ { "id": "1.0alpha7.train.368.sent", "type": "sentence", "text": [ " Use of this approach showed that ZAG can bind several different types of fatty acids, all of which are abundant in human tissues. " ], "offsets": [ [ 0, 135 ] ] } ]
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[]
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1.0alpha7.train.369
25318960
[ { "id": "1.0alpha7.train.369.sent", "type": "sentence", "text": [ "(B) PlexB binds to Rac in a GTP-dependent manner." ], "offsets": [ [ 0, 52 ] ] } ]
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[]
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1.0alpha7.train.370
11356552
[ { "id": "1.0alpha7.train.370.sent", "type": "sentence", "text": [ "In in vitro assays, Su(fu) can bind directly to Fu and to Ci; since there is no evidence for a direct interaction between the latter proteins or indeed between them and Cos‐2, it may be that Su(fu) forms a bridge between them, stabilizing their association with one another and with Cos-2 (Monnier et al., 1998) (Figure 1). " ], "offsets": [ [ 0, 324 ] ] } ]
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[]
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1.0alpha7.train.371
2399738
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[]
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1.0alpha7.train.372
340366
[ { "id": "1.0alpha7.train.372.sent", "type": "sentence", "text": [ "The IL-11-inducible binding of Syp to both gp130 and JAK2 was shown by reciprocal immunoprecipitations." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
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1.0alpha7.train.373
25302485
[ { "id": "1.0alpha7.train.373.sent", "type": "sentence", "text": [ " It has been shown, by in vitro binding assay, that Ldb proteins only binds to the first LIM domain of Islet-1 and not to the second LIM domain (Jurata et al., 1996 ), leaving room for the second LIM domain to interact with some other cofactors. " ], "offsets": [ [ 0, 254 ] ] } ]
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[]
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1.0alpha7.train.374
12492614
[ { "id": "1.0alpha7.train.374.sent", "type": "sentence", "text": [ "The RGS domain of Axin binds APC (Behrens et al. 1998; Kishida et al. 1998), defined domains of Axin are required for binding GSK3β and β-catenin (Behrens et al. 1998; Ikeda et al. 1998; Sakanaka et al. 1998; Hedgepeth et al. 1999) and the carboxy-terminal DIX domain and more internal sequences are required for Axin homodimerization and binding to Dsh and LRP/Arrow (Hsu et al. 1999; Kishida et al. 1999; Li et al. 1999; Smalley et al. 1999; Mao et al. 2001). " ], "offsets": [ [ 0, 462 ] ] } ]
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[]
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1.0alpha7.train.375
6974947
[ { "id": "1.0alpha7.train.375.sent", "type": "sentence", "text": [ " Previously, it had been shown that GSK-3beta binds to beta-catenin in cell lines that contain high levels of beta-catenin and mutated APC ( 8). " ], "offsets": [ [ 0, 150 ] ] } ]
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[]
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1.0alpha7.train.376
9103599
[ { "id": "1.0alpha7.train.376.sent", "type": "sentence", "text": [ "Likewise, in vitro translated full-length Ets-1 did not bind to GST-EtsΔTA (Figure 2A, lanes 4 and 5)." ], "offsets": [ [ 0, 102 ] ] } ]
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1.0alpha7.train.377
3584988
[ { "id": "1.0alpha7.train.377.sent", "type": "sentence", "text": [ " In either case, the regulation of the balance of the binding of Dvl and Axam to Axin is important. " ], "offsets": [ [ 0, 104 ] ] } ]
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1.0alpha7.train.378
12609808
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1.0alpha7.train.379
11484185
[ { "id": "1.0alpha7.train.379.sent", "type": "sentence", "text": [ " Additional evidence that FKBP12 specifically recognizes the Leu-Pro motif is provided by previous reports (Okadome et al., 1996; Wang et al., 1996b) and present observations that rapamycin and FK506 inhibit FKBP12 binding to TbetaR-I. " ], "offsets": [ [ 0, 245 ] ] } ]
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[]
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1.0alpha7.train.380
2164945
[ { "id": "1.0alpha7.train.380.sent", "type": "sentence", "text": [ " C, Diva does not bind to Bcl-XL in 293T cells. " ], "offsets": [ [ 0, 51 ] ] } ]
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1.0alpha7.train.381
4118469
[ { "id": "1.0alpha7.train.381.sent", "type": "sentence", "text": [ "EMSA of NF-Y and HSP-CBF bound to the HSP70 (A) and HSP40 (B) proximal CCAAT box regions." ], "offsets": [ [ 0, 89 ] ] } ]
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1.0alpha7.train.382
3573954
[ { "id": "1.0alpha7.train.382.sent", "type": "sentence", "text": [ "The ability of the specific K266A mutant to abolish binding of AIP to hsp90 and substantially reduce binding to AhR, coupled with the ability of AIP to bind directly to hsp90 and the pharmacological characterization of the binding of AIP to AhR, provides compelling evidence that hsp90 is required for binding between AhR and AIP." ], "offsets": [ [ 0, 330 ] ] } ]
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1.0alpha7.train.383
15592346
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[]
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1.0alpha7.train.384
15237557
[ { "id": "1.0alpha7.train.384.sent", "type": "sentence", "text": [ " Finally, the significance of the fact that TFIID (and TFIIA) binds both TFIID-dependent and TFIID-independent promoters ( 42) with comparable efficiency (in vitro) also awaits further study. " ], "offsets": [ [ 0, 197 ] ] } ]
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1.0alpha7.train.385
15338391
[ { "id": "1.0alpha7.train.385.sent", "type": "sentence", "text": [ " It is possible, therefore, that, upon the binding of GRF2 to Ras, the DB is exposed to the ubiquitination machinery, resulting in the ubiquitination of GRF2. " ], "offsets": [ [ 0, 164 ] ] } ]
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[]
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1.0alpha7.train.386
3950115
[ { "id": "1.0alpha7.train.386.sent", "type": "sentence", "text": [ " Obviously, the immunoblots will show whether or not PTN binds to the ALK ECD, but they will not reveal as to whether other unidentified proteins present in the PTN preparation also bind. " ], "offsets": [ [ 0, 195 ] ] } ]
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[]
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1.0alpha7.train.387
16061165
[ { "id": "1.0alpha7.train.387.sent", "type": "sentence", "text": [ " HP1 chromodomain does not bind histone H3 containing methyllysine 4 ( 7), a posttranslational modification associated with transcriptional activation ( 18), because the sequence context of the Lys4 (ARTK4Q) is not shared with Lys9. " ], "offsets": [ [ 0, 241 ] ] } ]
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[]
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1.0alpha7.train.388
1986162
[ { "id": "1.0alpha7.train.388.sent", "type": "sentence", "text": [ " In addition to binding filamin, it has been previously reported that beta1 can bind focal adhesion kinase ( 52) and the cytoplasmic proteins talin ( 53), paxillin ( 52), and alpha-actinin ( 54). " ], "offsets": [ [ 0, 203 ] ] } ]
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[]
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1.0alpha7.train.389
18041722
[ { "id": "1.0alpha7.train.389.sent", "type": "sentence", "text": [ "Second, the ankyrin repeat-containing serine-threonine kinase, integrin-linked kinase (ILK), which binds the cytoplasmic domain of β1 and β3 integrin subunits, promotes contact-independent growth and directly induces cyclin D1 expression and transcription (D'Amico et al., 2000)." ], "offsets": [ [ 0, 279 ] ] } ]
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[]
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1.0alpha7.train.390
9239313
[ { "id": "1.0alpha7.train.390.sent", "type": "sentence", "text": [ "U2AF bound to the PY tract and AG within exon 3 recruits U2 snRNP to the BPS." ], "offsets": [ [ 0, 77 ] ] } ]
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[]
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1.0alpha7.train.391
3182612
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[]
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1.0alpha7.train.392
21892012
[ { "id": "1.0alpha7.train.392.sent", "type": "sentence", "text": [ " A further complication arises if it can be confirmed that Munc13-1 binding to syntaxin is not affected by phorbol esters (see Rhee et al., 2002 , p. 131). " ], "offsets": [ [ 0, 163 ] ] } ]
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[]
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1.0alpha7.train.393
1731631
[ { "id": "1.0alpha7.train.393.sent", "type": "sentence", "text": [ " Several individual amino acid residues in Shc have been implicated by site-directed mutagenesis to be critical for Shc binding to the psi XNP XpY motif ( 17, 19, 20). " ], "offsets": [ [ 0, 174 ] ] } ]
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[]
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1.0alpha7.train.394
16045025
[ { "id": "1.0alpha7.train.394.sent", "type": "sentence", "text": [ "As adapter proteins, Shc binds to activated receptors such as epidermal growth factor, nerve growth factor, and antigen receptors, and IRS binds to activated insulin receptor, so as to transduce signals to downstream effector proteins (reviewed in reference 37)." ], "offsets": [ [ 0, 262 ] ] } ]
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[]
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1.0alpha7.train.395
15088726
[ { "id": "1.0alpha7.train.395.sent", "type": "sentence", "text": [ "HSP27 binds to the 26S proteasome complex." ], "offsets": [ [ 0, 42 ] ] } ]
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[]
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1.0alpha7.train.396
11579877
[ { "id": "1.0alpha7.train.396.sent", "type": "sentence", "text": [ "MSL complex binding at roX1 transgenes requires MLE." ], "offsets": [ [ 0, 55 ] ] } ]
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[]
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1.0alpha7.train.397
11977641
[ { "id": "1.0alpha7.train.397.sent", "type": "sentence", "text": [ "The reduction in ordering of C-terminal portions of the CRIB motif on binding the GTPase, and consequent reduction of a significant conformational entropic penalty on binding, may explain how Par6 can bind Cdc42 with high affinity even though its CRIB motif lacks conserved elements found in other systems (Burbelo et al., 1995)." ], "offsets": [ [ 0, 329 ] ] } ]
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[]
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1.0alpha7.train.398
11349322
[ { "id": "1.0alpha7.train.398.sent", "type": "sentence", "text": [ "Taking advantage of the fact that high Ca2+ concentrations can be easily achieved in solution to detect weak binding sites, we have now determined the complete Ca2+‐binding mode of the C2A‐domain of synaptotagmin I using a combination of Mn2+‐induced relaxation experiments, site‐directed mutagenesis and Ca2+ titrations monitored by NMR spectroscopy." ], "offsets": [ [ 0, 351 ] ] } ]
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[]
[ { "id": "1.0alpha7.train.398.coref0", "entity_ids": [ "1.0alpha7.train.398.ent0_0" ] }, { "id": "1.0alpha7.train.398.coref1", "entity_ids": [ "1.0alpha7.train.398.ent1_0", "1.0alpha7.train.398.ent2_1", "1.0alpha7.train.398.ent3_2" ] }, { "id": "1.0alpha7.train.398.coref2", "entity_ids": [ "1.0alpha7.train.398.ent4_0" ] }, { "id": "1.0alpha7.train.398.coref3", "entity_ids": [ "1.0alpha7.train.398.ent5_0" ] }, { "id": "1.0alpha7.train.398.coref4", "entity_ids": [ "1.0alpha7.train.398.ent6_0" ] } ]
[ { "id": "1.0alpha7.train.398.rel0s1.0alpha7.train.398.ent0_0.o1.0alpha7.train.398.ent1_0", "type": "bind", "arg1_id": "1.0alpha7.train.398.ent0_0", "arg2_id": "1.0alpha7.train.398.ent1_0", "normalized": [] }, { "id": "1.0alpha7.train.398.rel0s1.0alpha7.train.398.ent0_0.o1.0alpha7.train.398.ent2_1", "type": "bind", "arg1_id": "1.0alpha7.train.398.ent0_0", "arg2_id": "1.0alpha7.train.398.ent2_1", "normalized": [] }, { "id": "1.0alpha7.train.398.rel0s1.0alpha7.train.398.ent0_0.o1.0alpha7.train.398.ent3_2", "type": "bind", "arg1_id": "1.0alpha7.train.398.ent0_0", "arg2_id": "1.0alpha7.train.398.ent3_2", "normalized": [] } ]
1.0alpha7.train.399
2874772
[ { "id": "1.0alpha7.train.399.sent", "type": "sentence", "text": [ " Buffers contained 10 muM FAD; binding was carried out at 40 mM imidazole, washing at 60 mM, and elution at 400 mM for the first cycle and 300 mM for the second. " ], "offsets": [ [ 0, 165 ] ] } ]
[ { "id": "1.0alpha7.train.399.ent0_0", "type": "chemical", "text": [ "FAD" ], "offsets": [ [ 27, 30 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "643975" } ] }, { "id": "1.0alpha7.train.399.ent1_0", "type": "chemical", "text": [ "imidazole" ], "offsets": [ [ 66, 75 ] ], "normalized": [ { "db_name": "pubchem:compound", "db_id": "795" } ] } ]
[]
[ { "id": "1.0alpha7.train.399.coref0", "entity_ids": [ "1.0alpha7.train.399.ent0_0" ] }, { "id": "1.0alpha7.train.399.coref1", "entity_ids": [ "1.0alpha7.train.399.ent1_0" ] } ]
[]