Datasets:

Languages: en
Multilinguality: monolingual
Licenses: unknown
Language Creators: found
Annotations Creators: expert-generated
Source Datasets: original
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text (string)label (class label)
Intravenous azithromycin-induced ototoxicity.
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Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation.
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Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol.
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METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.
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METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.
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Naproxen, the most common offender, has been associated with a dimorphic clinical pattern: a PCT-like presentation and one simulating erythropoietic protoporphyria in the pediatric population.
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RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.
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RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.
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RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.
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RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.
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BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.
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CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.
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Prolonged severe 5-fluorouracil-associated neurotoxicity in a patient with dihydropyrimidine dehydrogenase deficiency.
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We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.
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We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.
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We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.
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This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.
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We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.
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We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.
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In one case, the readministration of riluzole was followed by the relapse of hepatitis.
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We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.
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Lupus-like syndrome caused by 5-aminosalicylic acid in patients with inflammatory bowel disease.
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Although the two local anesthetics usually do not cause methemoglobinemia, we suspect that the displacement of lidocaine from protein binding by bupivacaine, in combination with metabolic acidosis and treatment with other oxidants, was the reason for the development of methemoglobinemia.
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Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.
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Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.
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We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field.
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We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field.
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Detection of activated eosinophils in nasal polyps of an aspirin-induced asthma patient.
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An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.
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We believe that this represents an unusual case of moderate-dose MTX-induced neurotoxicity in a patient with gastric cancer, which has not previously been reported.
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We describe a life threatening side effect of acute epoprostenol infusion (pulmonary edema) in a patient with pulmonary hypertension associated with limited scleroderma and discuss its management and potential etiology.
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A 14-year-old girl with newly diagnosed SLE developed a pruritic bullous eruption while on prednisone.
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Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.
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The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea.
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This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.
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Allergic and irritant contact dermatitis to calcipotriol.
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Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.
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Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.
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The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.
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Myotonia associated with sarcoidosis: marked exacerbation with pravastatin.
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Pravastatin is associated with myotonia in animals.
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This case suggests that sarcoidosis and pravastatin, two entities not frequently associated with myotonia, may interact in a synergistic manner to produce severe clinical myotonia in humans.
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Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.
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Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.
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Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.
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CONCLUSION: Fixed drug eruption is associated with many drugs but this is the first such report with omeprazole.
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Fixed drug eruption in hands caused by omeprazole.
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The objective of this report is to describe a case of fixed drug eruption that occurred during omeprazole treatment.
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A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.
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A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.
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A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.
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A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.
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Acute generalized exanthematous pustulosis induced by salazosulfapyridine in a patient with ulcerative colitis.
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We report a case of acute generalized exanthematous pustulosis (AGEP) induced by salazosulfapyridine in a patient with ulcerative colitis.
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CASE SUMMARY: A 39-year-old white Jewish schizophrenic man treated with olanzapine developed an elevated serum CK concentration with a peak concentration of 4000 IU/L (normal < 230).
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DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.
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Marked elevation of serum creatine kinase associated with olanzapine therapy.
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OBJECTIVE: To report a case of marked elevation of serum creatine kinase (CK) associated with olanzapine therapy.
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Diclofenac-associated hepatitis.
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This patient, who had a history of osteoarthritis, had severe hepatitis 5 weeks after being started on diclofenac for increasing pain in the joints.
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2-CdA induces lymphocytopenia, which may explain the improvement in this patient's psoriasis.
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One case of priapism occurred during heparin therapy for a previous surgical operation to the knee is reported.
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Priapism as a complication of heparin therapy.
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The association between heparin and priapism is often recognized; abnormal platelet aggregation could play a role in the pathogenesis of this side effect.
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The association between heparin and priapism is often recognized; abnormal platelet aggregation could play a role in the pathogenesis of this side effect.
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It carries a well-known risk of neutropenia and agranulocytosis, which necessitates the immediate discontinuation of clozapine.
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It carries a well-known risk of neutropenia and agranulocytosis, which necessitates the immediate discontinuation of clozapine.
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OBJECTIVE: We report a patient who developed neutropenia on clozapine, but behind the cell count decrease showed to be a diurnal variation of the white blood cells (WBC).
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Acute neutrophilic dermatosis induced by all-trans-retinoic acid treatment for acute promyelocytic leukemia.
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Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.
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Hair loss associated with paroxetine treatment: a case report.
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We report on a 37-year-old female who complained of moderate hair loss during paroxetine treatment.
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CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.
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METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.
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METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.
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METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.
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METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.
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METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.
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METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.
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OBJECTIVE: The purpose of this study was to determine whether desensitization to NPH insulin, as well as standard insulin desensitization, could control allergic symptoms in a patient allergic to both NPH and regular insulin.
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OBJECTIVE: The purpose of this study was to determine whether desensitization to NPH insulin, as well as standard insulin desensitization, could control allergic symptoms in a patient allergic to both NPH and regular insulin.
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Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.
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Protamine allergy as a complication of insulin hypersensitivity: A case report.
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She continued to receive regular insulin 4 times per day over the following 3 years with only occasional hives.
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The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.
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The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.
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The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.
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The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.
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A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.
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A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.
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An 11-day-old infant became lethargic and apneic after a single drop of brimonidine.
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An 11-day-old infant became lethargic and apneic after a single drop of brimonidine.
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Apparent central nervous system depression in infants after the use of topical brimonidine.
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CONCLUSIONS: Topical brimonidine may be associated with central nervous system depression in infants.
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PURPOSE: To report two cases in which topical brimonidine resulted in apparent central nervous system depression and unresponsiveness in an infant.
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Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato-biliary enzymes and transient biliary stasis.
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Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato-biliary enzymes and transient biliary stasis.
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Hepato-biliary abnormalities secondary to ceftriaxone use: a case report.
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Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.
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Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery.
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Dataset Card for Adverse Drug Reaction Data v2

Dataset Summary

ADE-Corpus-V2 Dataset: Adverse Drug Reaction Data. This is a dataset for Classification if a sentence is ADE-related (True) or not (False) and Relation Extraction between Adverse Drug Event and Drug. DRUG-AE.rel provides relations between drugs and adverse effects. DRUG-DOSE.rel provides relations between drugs and dosages. ADE-NEG.txt provides all sentences in the ADE corpus that DO NOT contain any drug-related adverse effects.

Supported Tasks and Leaderboards

Sentiment classification, Relation Extraction

Languages

English

Dataset Structure

Data Instances

Config - Ade_corpus_v2_classification

{
      'label': 1, 
      'text': 'Intravenous azithromycin-induced ototoxicity.'
}

Config - Ade_corpus_v2_drug_ade_relation

{ 
    'drug': 'azithromycin', 
    'effect': 'ototoxicity', 
    'indexes': {
                  'drug': {
                            'end_char': [24], 
                            'start_char': [12]
                          }, 
                  'effect': {
                            'end_char': [44], 
                            'start_char': [33]
                            }
                }, 
    'text': 'Intravenous azithromycin-induced ototoxicity.'
    
}

Config - Ade_corpus_v2_drug_dosage_relation

{
    'dosage': '4 times per day', 
    'drug': 'insulin', 
    'indexes': {
                'dosage': {
                            'end_char': [56], 
                            'start_char': [41]
                        }, 
                'drug': {
                          'end_char': [40], 
                          'start_char': [33]}
                        }, 
    'text': 'She continued to receive regular insulin 4 times per day over the following 3 years with only occasional hives.'
}

Data Fields

Config - Ade_corpus_v2_classification

  • text - Input text.

  • label - Whether the adverse drug effect(ADE) related (1) or not (0).

  • Config - Ade_corpus_v2_drug_ade_relation

  • text - Input text.

  • drug - Name of drug.

  • effect - Effect caused by the drug.

  • indexes.drug.start_char - Start index of drug string in text.

  • indexes.drug.end_char - End index of drug string in text.

  • indexes.effect.start_char - Start index of effect string in text.

  • indexes.effect.end_char - End index of effect string in text.

Config - Ade_corpus_v2_drug_dosage_relation

  • text - Input text.
  • drug - Name of drug.
  • dosage - Dosage of the drug.
  • indexes.drug.start_char - Start index of drug string in text.
  • indexes.drug.end_char - End index of drug string in text.
  • indexes.dosage.start_char - Start index of dosage string in text.
  • indexes.dosage.end_char - End index of dosage string in text.

Data Splits

Train
23516

Dataset Creation

Curation Rationale

[Needs More Information]

Source Data

Initial Data Collection and Normalization

[Needs More Information]

Who are the source language producers?

[Needs More Information]

Annotations

Annotation process

[Needs More Information]

Who are the annotators?

[Needs More Information]

Personal and Sensitive Information

[Needs More Information]

Considerations for Using the Data

Social Impact of Dataset

[Needs More Information]

Discussion of Biases

[Needs More Information]

Other Known Limitations

[Needs More Information]

Additional Information

Dataset Curators

[Needs More Information]

Licensing Information

[Needs More Information]

Citation Information

@article{GURULINGAPPA2012885,
title = "Development of a benchmark corpus to support the automatic extraction of drug-related adverse effects from medical case reports",
journal = "Journal of Biomedical Informatics",
volume = "45",
number = "5",
pages = "885 - 892",
year = "2012",
note = "Text Mining and Natural Language Processing in Pharmacogenomics",
issn = "1532-0464",
doi = "https://doi.org/10.1016/j.jbi.2012.04.008",
url = "http://www.sciencedirect.com/science/article/pii/S1532046412000615",
author = "Harsha Gurulingappa and Abdul Mateen Rajput and Angus Roberts and Juliane Fluck and Martin Hofmann-Apitius and Luca Toldo",
keywords = "Adverse drug effect, Benchmark corpus, Annotation, Harmonization, Sentence classification",
abstract = "A significant amount of information about drug-related safety issues such as adverse effects are published in medical case reports that can only be explored by human readers due to their unstructured nature. The work presented here aims at generating a systematically annotated corpus that can support the development and validation of methods for the automatic extraction of drug-related adverse effects from medical case reports. The documents are systematically double annotated in various rounds to ensure consistent annotations. The annotated documents are finally harmonized to generate representative consensus annotations. In order to demonstrate an example use case scenario, the corpus was employed to train and validate models for the classification of informative against the non-informative sentences. A Maximum Entropy classifier trained with simple features and evaluated by 10-fold cross-validation resulted in the F1 score of 0.70 indicating a potential useful application of the corpus."
}

Contributions

Thanks to @Nilanshrajput, @lhoestq for adding this dataset.

Models trained or fine-tuned on ade_corpus_v2