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<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"alpha-methyldopa"/ induces disease /"hypotensive"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Naloxone reverses the antihypertensive effect of clonidine. - Abstract: In unanesthetized, spontaneously hypertensive rats the decrease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms/kg, was inhibited or reversed by nalozone, 0.2 to 2 mg/kg. The /"hypotensive"/ effect of 100 mg/kg /"alpha-methyldopa"/ was also partially reversed by naloxone. Naloxone alone did not affect either blood pressure or heart rate. In brain membranes from spontaneously hypertensive rats clonidine, 10(-8) to 10(-5) M, did not influence stereoselective binding of [3H]-naloxone (8 nM), and naloxone, 10(-8) to 10(-4) M, did not influence clonidine-suppressible binding of [3H]-dihydroergocryptine (1 nM). These findings indicate that in spontaneously hypertensive rats the effects of central alpha-adrenoceptor stimulation involve activation of opiate receptors. As naloxone and clonidine do not appear to interact with the same receptor site, the observed functional antagonism suggests the release of an endogenous opiate by clonidine or /"alpha-methyldopa"/ and the possible role of the opiate in the central control of sympathetic tone. Question: Does chemical /"alpha-methyldopa"/ induce disease /"hypotensive"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"alpha-methyldopa"/ induces disease /"hypertensive"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Naloxone reverses the antihypertensive effect of clonidine. - Abstract: In unanesthetized, spontaneously /"hypertensive"/ rats the decrease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms/kg, was inhibited or reversed by nalozone, 0.2 to 2 mg/kg. The hypotensive effect of 100 mg/kg /"alpha-methyldopa"/ was also partially reversed by naloxone. Naloxone alone did not affect either blood pressure or heart rate. In brain membranes from spontaneously /"hypertensive"/ rats clonidine, 10(-8) to 10(-5) M, did not influence stereoselective binding of [3H]-naloxone (8 nM), and naloxone, 10(-8) to 10(-4) M, did not influence clonidine-suppressible binding of [3H]-dihydroergocryptine (1 nM). These findings indicate that in spontaneously /"hypertensive"/ rats the effects of central alpha-adrenoceptor stimulation involve activation of opiate receptors. As naloxone and clonidine do not appear to interact with the same receptor site, the observed functional antagonism suggests the release of an endogenous opiate by clonidine or /"alpha-methyldopa"/ and the possible role of the opiate in the central control of sympathetic tone. Question: Does chemical /"alpha-methyldopa"/ induce disease /"hypertensive"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Lidocaine"/ induces disease /"cardiac asystole"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Lidocaine"/-induced /"cardiac asystole"/. - Abstract: Intravenous administration of a single 50-mg bolus of /"lidocaine"/ in a 67-year-old man resulted in profound depression of the activity of the sinoatrial and atrioventricular nodal pacemakers. The patient had no apparent associated conditions which might have predisposed him to the development of bradyarrhythmias; and, thus, this probably represented a true idiosyncrasy to /"lidocaine"/. Question: Does chemical /"Lidocaine"/ induce disease /"cardiac asystole"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Lidocaine"/ induces disease /"bradyarrhythmias"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Lidocaine"/-induced cardiac asystole. - Abstract: Intravenous administration of a single 50-mg bolus of /"lidocaine"/ in a 67-year-old man resulted in profound depression of the activity of the sinoatrial and atrioventricular nodal pacemakers. The patient had no apparent associated conditions which might have predisposed him to the development of /"bradyarrhythmias"/; and, thus, this probably represented a true idiosyncrasy to /"lidocaine"/. Question: Does chemical /"Lidocaine"/ induce disease /"bradyarrhythmias"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Suxamethonium"/ induces disease /"fasciculations"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Suxamethonium"/ infusion rate and observed /"fasciculations"/. A dose-response study. - Abstract: /"Suxamethonium chloride"/ (/"Sch"/) was administered i.v. to 36 adult males at six rates: 0.25 mg s-1 to 20 mg s-1. The infusion was discontinued either when there was no muscular response to tetanic stimulation of the ulnar nerve or when /"Sch"/ 120 mg was exceeded. Six additional patients received a 30-mg i.v. bolus dose. /"Fasciculations"/ in six areas of the body were scored from 0 to 3 and summated as a total /"fasciculation"/ score. The times to first /"fasciculation"/, twitch suppression and tetanus suppression were inversely related to the infusion rates. /"Fasciculations"/ in the six areas and the total /"fasciculation"/ score were related directly to the rate of infusion. Total /"fasciculation"/ scores in the 30-mg bolus group and the 5-mg s-1 and 20-mg s-1 infusion groups were not significantly different. Question: Does chemical /"Suxamethonium"/ induce disease /"fasciculations"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Suxamethonium"/ induces disease /"tetanic"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Suxamethonium"/ infusion rate and observed fasciculations. A dose-response study. - Abstract: /"Suxamethonium chloride"/ (/"Sch"/) was administered i.v. to 36 adult males at six rates: 0.25 mg s-1 to 20 mg s-1. The infusion was discontinued either when there was no muscular response to /"tetanic"/ stimulation of the ulnar nerve or when /"Sch"/ 120 mg was exceeded. Six additional patients received a 30-mg i.v. bolus dose. Fasciculations in six areas of the body were scored from 0 to 3 and summated as a total fasciculation score. The times to first fasciculation, /"twitch"/ suppression and /"tetanus"/ suppression were inversely related to the infusion rates. Fasciculations in the six areas and the total fasciculation score were related directly to the rate of infusion. Total fasciculation scores in the 30-mg bolus group and the 5-mg s-1 and 20-mg s-1 infusion groups were not significantly different. Question: Does chemical /"Suxamethonium"/ induce disease /"tetanic"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"scopolamine"/ induces disease /"overdosage"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of /"scopolamine"/ (/"Hyoscine"/). - Abstract: Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-brain barrier, was used in a patient demonstrating central effects of /"scopolamine"/ (/"hyoscine"/) /"overdosage"/. It is longer acting than physostigmine and is used in anaesthesia to reverse the non-depolarizing neuromuscular block. However, studies into the dose necessary to combating /"scopolamine"/ intoxication are indicated. Question: Does chemical /"scopolamine"/ induce disease /"overdosage"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Galanthamine hydrobromide"/ induces disease /"overdosage"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Galanthamine hydrobromide"/, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine). - Abstract: /"Galanthamine hydrobromide"/, an anticholinesterase drug capable of penetrating the blood-brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) /"overdosage"/. It is longer acting than physostigmine and is used in anaesthesia to reverse the non-depolarizing neuromuscular block. However, studies into the dose necessary to combating scopolamine intoxication are indicated. Question: Does chemical /"Galanthamine hydrobromide"/ induce disease /"overdosage"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"lithium"/ induces disease /"hypertension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Effects of uninephrectomy and high protein feeding on /"lithium"/-induced chronic renal failure in rats. - Abstract: Rats with /"lithium"/-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal failure. Newborn female Wistar rats were fed a /"lithium"/-containing diet (50 mmol/kg) for 8 weeks and then randomized to normal diet, HP diet (40 vs. 19%), NX or HP+NX for another 8 weeks. Corresponding non-/"lithium"/ pretreated groups were generated. When comparing all /"lithium"/ treated versus non-/"lithium"/-treated groups, /"lithium"/ caused a reduction in glomerular filtration rate (GFR) without significant changes in effective renal plasma flow (as determined by a marker secreted into the proximal tubules) or /"lithium"/ clearance. Consequently, /"lithium"/ pretreatment caused a fall in filtration fraction and an increase in fractional /"Li"/ excretion. /"Lithium"/ also caused proteinuria and systolic /"hypertension"/ in absence of glomerulosclerosis. HP failed to accentuante progression of renal failure and in fact tended to increase GFR and decrease plasma creatinine levels in /"lithium"/ pretreated rats. NX caused an additive deterioration in GFR which, however, was ameliorated by HP. NX+HP caused a further rise in blood pressure in /"Li"/-pretreated rats. The results indicate that /"Li"/-induced nephropathy, even when the GFR is only modestly reduced, is associated with proteinuria and arterial systolic /"hypertension"/. In this model of chronic renal failure the decline in GFR is not accompanied by a corresponding fall in effective renal plasma flow, which may be the functional expression of the formation of nonfiltrating atubular glomeruli. The fractional reabsorption of tubular fluid by the proximal tubules is reduced, leaving the distal delivery unchanged.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"lithium"/ induce disease /"hypertension"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"lithium"/ induces disease /"proteinuria"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Effects of uninephrectomy and high protein feeding on /"lithium"/-induced chronic renal failure in rats. - Abstract: Rats with /"lithium"/-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal failure. Newborn female Wistar rats were fed a /"lithium"/-containing diet (50 mmol/kg) for 8 weeks and then randomized to normal diet, HP diet (40 vs. 19%), NX or HP+NX for another 8 weeks. Corresponding non-/"lithium"/ pretreated groups were generated. When comparing all /"lithium"/ treated versus non-/"lithium"/-treated groups, /"lithium"/ caused a reduction in glomerular filtration rate (GFR) without significant changes in effective renal plasma flow (as determined by a marker secreted into the proximal tubules) or /"lithium"/ clearance. Consequently, /"lithium"/ pretreatment caused a fall in filtration fraction and an increase in fractional /"Li"/ excretion. /"Lithium"/ also caused /"proteinuria"/ and systolic hypertension in absence of glomerulosclerosis. HP failed to accentuante progression of renal failure and in fact tended to increase GFR and decrease plasma creatinine levels in /"lithium"/ pretreated rats. NX caused an additive deterioration in GFR which, however, was ameliorated by HP. NX+HP caused a further rise in blood pressure in /"Li"/-pretreated rats. The results indicate that /"Li"/-induced nephropathy, even when the GFR is only modestly reduced, is associated with /"proteinuria"/ and arterial systolic hypertension. In this model of chronic renal failure the decline in GFR is not accompanied by a corresponding fall in effective renal plasma flow, which may be the functional expression of the formation of nonfiltrating atubular glomeruli. The fractional reabsorption of tubular fluid by the proximal tubules is reduced, leaving the distal delivery unchanged.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"lithium"/ induce disease /"proteinuria"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"lithium"/ induces disease /"chronic renal failure"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Effects of uninephrectomy and high protein feeding on /"lithium"/-induced /"chronic renal failure"/ in rats. - Abstract: Rats with /"lithium"/-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal failure. Newborn female Wistar rats were fed a /"lithium"/-containing diet (50 mmol/kg) for 8 weeks and then randomized to normal diet, HP diet (40 vs. 19%), NX or HP+NX for another 8 weeks. Corresponding non-/"lithium"/ pretreated groups were generated. When comparing all /"lithium"/ treated versus non-/"lithium"/-treated groups, /"lithium"/ caused a reduction in glomerular filtration rate (GFR) without significant changes in effective renal plasma flow (as determined by a marker secreted into the proximal tubules) or /"lithium"/ clearance. Consequently, /"lithium"/ pretreatment caused a fall in filtration fraction and an increase in fractional /"Li"/ excretion. /"Lithium"/ also caused proteinuria and systolic hypertension in absence of glomerulosclerosis. HP failed to accentuante progression of renal failure and in fact tended to increase GFR and decrease plasma creatinine levels in /"lithium"/ pretreated rats. NX caused an additive deterioration in GFR which, however, was ameliorated by HP. NX+HP caused a further rise in blood pressure in /"Li"/-pretreated rats. The results indicate that /"Li"/-induced nephropathy, even when the GFR is only modestly reduced, is associated with proteinuria and arterial systolic hypertension. In this model of /"chronic renal failure"/ the decline in GFR is not accompanied by a corresponding fall in effective renal plasma flow, which may be the functional expression of the formation of nonfiltrating atubular glomeruli. The fractional reabsorption of tubular fluid by the proximal tubules is reduced, leaving the distal delivery unchanged.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"lithium"/ induce disease /"chronic renal failure"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"creatinine"/ induces disease /"chronic renal failure"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Effects of uninephrectomy and high protein feeding on lithium-induced /"chronic renal failure"/ in rats. - Abstract: Rats with lithium-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal failure. Newborn female Wistar rats were fed a lithium-containing diet (50 mmol/kg) for 8 weeks and then randomized to normal diet, HP diet (40 vs. 19%), NX or HP+NX for another 8 weeks. Corresponding non-lithium pretreated groups were generated. When comparing all lithium treated versus non-lithium-treated groups, lithium caused a reduction in glomerular filtration rate (GFR) without significant changes in effective renal plasma flow (as determined by a marker secreted into the proximal tubules) or lithium clearance. Consequently, lithium pretreatment caused a fall in filtration fraction and an increase in fractional Li excretion. Lithium also caused proteinuria and systolic hypertension in absence of glomerulosclerosis. HP failed to accentuante progression of renal failure and in fact tended to increase GFR and decrease plasma /"creatinine"/ levels in lithium pretreated rats. NX caused an additive deterioration in GFR which, however, was ameliorated by HP. NX+HP caused a further rise in blood pressure in Li-pretreated rats. The results indicate that Li-induced nephropathy, even when the GFR is only modestly reduced, is associated with proteinuria and arterial systolic hypertension. In this model of /"chronic renal failure"/ the decline in GFR is not accompanied by a corresponding fall in effective renal plasma flow, which may be the functional expression of the formation of nonfiltrating atubular glomeruli. The fractional reabsorption of tubular fluid by the proximal tubules is reduced, leaving the distal delivery unchanged.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"creatinine"/ induce disease /"chronic renal failure"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"creatinine"/ induces disease /"glomerulosclerosis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Effects of uninephrectomy and high protein feeding on lithium-induced chronic renal failure in rats. - Abstract: Rats with lithium-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal failure. Newborn female Wistar rats were fed a lithium-containing diet (50 mmol/kg) for 8 weeks and then randomized to normal diet, HP diet (40 vs. 19%), NX or HP+NX for another 8 weeks. Corresponding non-lithium pretreated groups were generated. When comparing all lithium treated versus non-lithium-treated groups, lithium caused a reduction in glomerular filtration rate (GFR) without significant changes in effective renal plasma flow (as determined by a marker secreted into the proximal tubules) or lithium clearance. Consequently, lithium pretreatment caused a fall in filtration fraction and an increase in fractional Li excretion. Lithium also caused proteinuria and systolic hypertension in absence of /"glomerulosclerosis"/. HP failed to accentuante progression of renal failure and in fact tended to increase GFR and decrease plasma /"creatinine"/ levels in lithium pretreated rats. NX caused an additive deterioration in GFR which, however, was ameliorated by HP. NX+HP caused a further rise in blood pressure in Li-pretreated rats. The results indicate that Li-induced nephropathy, even when the GFR is only modestly reduced, is associated with proteinuria and arterial systolic hypertension. In this model of chronic renal failure the decline in GFR is not accompanied by a corresponding fall in effective renal plasma flow, which may be the functional expression of the formation of nonfiltrating atubular glomeruli. The fractional reabsorption of tubular fluid by the proximal tubules is reduced, leaving the distal delivery unchanged.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"creatinine"/ induce disease /"glomerulosclerosis"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"lithium"/ induces disease /"nephropathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Effects of uninephrectomy and high protein feeding on /"lithium"/-induced chronic renal failure in rats. - Abstract: Rats with /"lithium"/-induced /"nephropathy"/ were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal failure. Newborn female Wistar rats were fed a /"lithium"/-containing diet (50 mmol/kg) for 8 weeks and then randomized to normal diet, HP diet (40 vs. 19%), NX or HP+NX for another 8 weeks. Corresponding non-/"lithium"/ pretreated groups were generated. When comparing all /"lithium"/ treated versus non-/"lithium"/-treated groups, /"lithium"/ caused a reduction in glomerular filtration rate (GFR) without significant changes in effective renal plasma flow (as determined by a marker secreted into the proximal tubules) or /"lithium"/ clearance. Consequently, /"lithium"/ pretreatment caused a fall in filtration fraction and an increase in fractional /"Li"/ excretion. /"Lithium"/ also caused proteinuria and systolic hypertension in absence of glomerulosclerosis. HP failed to accentuante progression of renal failure and in fact tended to increase GFR and decrease plasma creatinine levels in /"lithium"/ pretreated rats. NX caused an additive deterioration in GFR which, however, was ameliorated by HP. NX+HP caused a further rise in blood pressure in /"Li"/-pretreated rats. The results indicate that /"Li"/-induced /"nephropathy"/, even when the GFR is only modestly reduced, is associated with proteinuria and arterial systolic hypertension. In this model of chronic renal failure the decline in GFR is not accompanied by a corresponding fall in effective renal plasma flow, which may be the functional expression of the formation of nonfiltrating atubular glomeruli. The fractional reabsorption of tubular fluid by the proximal tubules is reduced, leaving the distal delivery unchanged.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"lithium"/ induce disease /"nephropathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"fusidic acid"/ induces disease /"nausea"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Treatment of Crohn's disease with /"fusidic acid"/: an antibiotic with immunosuppressive properties similar to cyclosporin. - Abstract: Fusidic acid is an antibiotic with T-cell specific immunosuppressive effects similar to those of cyclosporin. Because of the need for the development of new treatments for Crohn's disease, a pilot study was undertaken to estimate the pharmacodynamics and tolerability of /"fusidic acid"/ treatment in chronic active, therapy-resistant patients. Eight Crohn's disease patients were included. /"Fusidic acid"/ was administered orally in a dose of 500 mg t.d.s. and the treatment was planned to last 8 weeks. The disease activity was primarily measured by a modified individual grading score. Five of 8 patients (63%) improved during /"fusidic acid"/ treatment: 3 at two weeks and 2 after four weeks. There were no serious clinical side effects, but dose reduction was required in two patients because of /"nausea"/. Biochemically, an increase in alkaline phosphatases was noted in 5 of 8 cases (63%), and the greatest increases were seen in those who had elevated levels prior to treatment. All reversed to pre-treatment levels after cessation of treatment. The results of this pilot study suggest that /"fusidic acid"/ may be of benefit in selected chronic active Crohn's disease patients in whom conventional treatment is ineffective. Because there seems to exist a scientific rationale for the use of /"fusidic acid"/ at the cytokine level in inflammatory bowel disease, we suggest that the role of this treatment should be further investigated. Question: Does chemical /"fusidic acid"/ induce disease /"nausea"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cyclosporin"/ induces disease /"inflammatory bowel disease"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to /"cyclosporin"/. - Abstract: Fusidic acid is an antibiotic with T-cell specific immunosuppressive effects similar to those of /"cyclosporin"/. Because of the need for the development of new treatments for Crohn's disease, a pilot study was undertaken to estimate the pharmacodynamics and tolerability of fusidic acid treatment in chronic active, therapy-resistant patients. Eight Crohn's disease patients were included. Fusidic acid was administered orally in a dose of 500 mg t.d.s. and the treatment was planned to last 8 weeks. The disease activity was primarily measured by a modified individual grading score. Five of 8 patients (63%) improved during fusidic acid treatment: 3 at two weeks and 2 after four weeks. There were no serious clinical side effects, but dose reduction was required in two patients because of nausea. Biochemically, an increase in alkaline phosphatases was noted in 5 of 8 cases (63%), and the greatest increases were seen in those who had elevated levels prior to treatment. All reversed to pre-treatment levels after cessation of treatment. The results of this pilot study suggest that fusidic acid may be of benefit in selected chronic active Crohn's disease patients in whom conventional treatment is ineffective. Because there seems to exist a scientific rationale for the use of fusidic acid at the cytokine level in /"inflammatory bowel disease"/, we suggest that the role of this treatment should be further investigated. Question: Does chemical /"cyclosporin"/ induce disease /"inflammatory bowel disease"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cocaine"/ induces disease /"myocardial infarction"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized /"cocaine"/ abusers. - Abstract: The electrocardiograms (ECG) of 99 /"cocaine"/-abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the /"cocaine"/ abusers and none of the controls had ECG evidence of significant myocardial injury defined as /"myocardial infarction"/, ischemia, and bundle branch block. Question: Does chemical /"cocaine"/ induce disease /"myocardial infarction"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cocaine"/ induces disease /"bundle branch block"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized /"cocaine"/ abusers. - Abstract: The electrocardiograms (ECG) of 99 /"cocaine"/-abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the /"cocaine"/ abusers and none of the controls had ECG evidence of significant myocardial injury defined as myocardial infarction, ischemia, and /"bundle branch block"/. Question: Does chemical /"cocaine"/ induce disease /"bundle branch block"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cocaine"/ induces disease /"myocardial injury"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Electrocardiographic evidence of /"myocardial injury"/ in psychiatrically hospitalized /"cocaine"/ abusers. - Abstract: The electrocardiograms (ECG) of 99 /"cocaine"/-abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the /"cocaine"/ abusers and none of the controls had ECG evidence of significant /"myocardial injury"/ defined as myocardial infarction, ischemia, and bundle branch block. Question: Does chemical /"cocaine"/ induce disease /"myocardial injury"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cocaine"/ induces disease /"schizophrenic"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized /"cocaine"/ abusers. - Abstract: The electrocardiograms (ECG) of 99 /"cocaine"/-abusing patients were compared with the ECGs of 50 /"schizophrenic"/ controls. Eleven of the /"cocaine"/ abusers and none of the controls had ECG evidence of significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch block. Question: Does chemical /"cocaine"/ induce disease /"schizophrenic"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Sulpiride"/ induces disease /"tardive dystonia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Sulpiride"/-induced /"tardive dystonia"/. - Abstract: /"Sulpiride"/ is a selective D2-receptor antagonist with antipsychotic and antidepressant properties. Although initially thought to be free of extrapyramidal side effects, /"sulpiride"/-induced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a 37-year-old man who developed persistent segmental /"dystonia"/ within 2 months after starting /"sulpiride"/ therapy. We could not find any previous reports of /"sulpiride"/-induced /"tardive dystonia"/. Question: Does chemical /"Sulpiride"/ induce disease /"tardive dystonia"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Sulpiride"/ induces disease /"tardive dyskinesia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Sulpiride"/-induced tardive dystonia. - Abstract: /"Sulpiride"/ is a selective D2-receptor antagonist with antipsychotic and antidepressant properties. Although initially thought to be free of extrapyramidal side effects, /"sulpiride"/-induced /"tardive dyskinesia"/ and parkinsonism have been reported occasionally. We studied a 37-year-old man who developed persistent segmental dystonia within 2 months after starting /"sulpiride"/ therapy. We could not find any previous reports of /"sulpiride"/-induced tardive dystonia. Question: Does chemical /"Sulpiride"/ induce disease /"tardive dyskinesia"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"desferrioxamine"/ induces disease /"pigmentary retinal deposits"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Ocular and auditory toxicity in hemodialyzed patients receiving /"desferrioxamine"/. - Abstract: During an 18-month period of study 41 hemodialyzed patients receiving /"desferrioxamine"/ (10-40 mg/kg BW/3 times weekly) for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms of visual or auditory toxicity. Moreover, detailed ophthalmologic and audiologic studies disclosed abnormalities in 7 more asymptomatic patients. Visual toxicity was of retinal origin and was characterized by a tritan-type dyschromatopsy, sometimes associated with a loss of visual acuity and /"pigmentary retinal deposits"/. Auditory toxicity was characterized by a mid- to high-frequency neurosensorial hearing loss and the lesion was of the cochlear type. /"Desferrioxamine"/ withdrawal resulted in a complete recovery of visual function in 1 patient and partial recovery in 3, and a complete reversal of hearing loss in 3 patients and partial recovery in 3. This toxicity appeared in patients receiving the higher doses of /"desferrioxamine"/ or coincided with the normalization of ferritin or aluminium serum levels. The data indicate that audiovisual toxicity is not an infrequent complication in hemodialyzed patients receiving /"desferrioxamine"/. Periodical audiovisual monitoring should be performed on hemodialyzed patients receiving the drug in order to detect adverse effects as early as possible. Question: Does chemical /"desferrioxamine"/ induce disease /"pigmentary retinal deposits"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"desferrioxamine"/ induces disease /"Ocular and auditory toxicity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Ocular and auditory toxicity"/ in hemodialyzed patients receiving /"desferrioxamine"/. - Abstract: During an 18-month period of study 41 hemodialyzed patients receiving /"desferrioxamine"/ (10-40 mg/kg BW/3 times weekly) for the first time were monitored for detection of /"audiovisual toxicity"/. 6 patients presented clinical symptoms of /"visual or auditory toxicity"/. Moreover, detailed ophthalmologic and audiologic studies disclosed abnormalities in 7 more asymptomatic patients. Visual toxicity was of retinal origin and was characterized by a tritan-type dyschromatopsy, sometimes associated with a loss of visual acuity and pigmentary retinal deposits. Auditory toxicity was characterized by a mid- to high-frequency neurosensorial hearing loss and the lesion was of the cochlear type. /"Desferrioxamine"/ withdrawal resulted in a complete recovery of visual function in 1 patient and partial recovery in 3, and a complete reversal of hearing loss in 3 patients and partial recovery in 3. This toxicity appeared in patients receiving the higher doses of /"desferrioxamine"/ or coincided with the normalization of ferritin or aluminium serum levels. The data indicate that /"audiovisual toxicity"/ is not an infrequent complication in hemodialyzed patients receiving /"desferrioxamine"/. Periodical audiovisual monitoring should be performed on hemodialyzed patients receiving the drug in order to detect adverse effects as early as possible. Question: Does chemical /"desferrioxamine"/ induce disease /"Ocular and auditory toxicity"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"desferrioxamine"/ induces disease /"Ocular"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Ocular"/ and auditory /"Ocular"/ in hemodialyzed patients receiving /"desferrioxamine"/. - Abstract: During an 18-month period of study 41 hemodialyzed patients receiving /"desferrioxamine"/ (10-40 mg/kg BW/3 times weekly) for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms of /"visual"/ or auditory /"visual"/. Moreover, detailed ophthalmologic and audiologic studies disclosed abnormalities in 7 more asymptomatic patients. /"Visual toxicity"/ was of retinal origin and was characterized by a tritan-type dyschromatopsy, sometimes associated with /"a loss of visual acuity"/ and pigmentary retinal deposits. Auditory toxicity was characterized by a mid- to high-frequency neurosensorial hearing loss and the lesion was of the cochlear type. /"Desferrioxamine"/ withdrawal resulted in a complete recovery of visual function in 1 patient and partial recovery in 3, and a complete reversal of hearing loss in 3 patients and partial recovery in 3. This toxicity appeared in patients receiving the higher doses of /"desferrioxamine"/ or coincided with the normalization of ferritin or aluminium serum levels. The data indicate that audiovisual toxicity is not an infrequent complication in hemodialyzed patients receiving /"desferrioxamine"/. Periodical audiovisual monitoring should be performed on hemodialyzed patients receiving the drug in order to detect adverse effects as early as possible. Question: Does chemical /"desferrioxamine"/ induce disease /"Ocular"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"desferrioxamine"/ induces disease /"neurosensorial hearing loss"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Ocular and auditory toxicity in hemodialyzed patients receiving /"desferrioxamine"/. - Abstract: During an 18-month period of study 41 hemodialyzed patients receiving /"desferrioxamine"/ (10-40 mg/kg BW/3 times weekly) for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms of visual or auditory toxicity. Moreover, detailed ophthalmologic and audiologic studies disclosed abnormalities in 7 more asymptomatic patients. Visual toxicity was of retinal origin and was characterized by a tritan-type dyschromatopsy, sometimes associated with a loss of visual acuity and pigmentary retinal deposits. Auditory toxicity was characterized by a mid- to high-frequency /"neurosensorial hearing loss"/ and the lesion was of the cochlear type. /"Desferrioxamine"/ withdrawal resulted in a complete recovery of visual function in 1 patient and partial recovery in 3, and a complete reversal of hearing loss in 3 patients and partial recovery in 3. This toxicity appeared in patients receiving the higher doses of /"desferrioxamine"/ or coincided with the normalization of ferritin or aluminium serum levels. The data indicate that audiovisual toxicity is not an infrequent complication in hemodialyzed patients receiving /"desferrioxamine"/. Periodical audiovisual monitoring should be performed on hemodialyzed patients receiving the drug in order to detect adverse effects as early as possible. Question: Does chemical /"desferrioxamine"/ induce disease /"neurosensorial hearing loss"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"desferrioxamine"/ induces disease /"toxicity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Ocular and auditory toxicity in hemodialyzed patients receiving /"desferrioxamine"/. - Abstract: During an 18-month period of study 41 hemodialyzed patients receiving /"desferrioxamine"/ (10-40 mg/kg BW/3 times weekly) for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms of visual or auditory toxicity. Moreover, detailed ophthalmologic and audiologic studies disclosed abnormalities in 7 more asymptomatic patients. Visual toxicity was of retinal origin and was characterized by a tritan-type dyschromatopsy, sometimes associated with a loss of visual acuity and pigmentary retinal deposits. Auditory toxicity was characterized by a mid- to high-frequency neurosensorial hearing loss and the lesion was of the cochlear type. /"Desferrioxamine"/ withdrawal resulted in a complete recovery of visual function in 1 patient and partial recovery in 3, and a complete reversal of hearing loss in 3 patients and partial recovery in 3. This /"toxicity"/ appeared in patients receiving the higher doses of /"desferrioxamine"/ or coincided with the normalization of ferritin or aluminium serum levels. The data indicate that audiovisual toxicity is not an infrequent complication in hemodialyzed patients receiving /"desferrioxamine"/. Periodical audiovisual monitoring should be performed on hemodialyzed patients receiving the drug in order to detect adverse effects as early as possible. Question: Does chemical /"desferrioxamine"/ induce disease /"toxicity"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"desferrioxamine"/ induces disease /"hearing loss"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Ocular and auditory toxicity in hemodialyzed patients receiving /"desferrioxamine"/. - Abstract: During an 18-month period of study 41 hemodialyzed patients receiving /"desferrioxamine"/ (10-40 mg/kg BW/3 times weekly) for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms of visual or auditory toxicity. Moreover, detailed ophthalmologic and audiologic studies disclosed abnormalities in 7 more asymptomatic patients. Visual toxicity was of retinal origin and was characterized by a tritan-type dyschromatopsy, sometimes associated with a loss of visual acuity and pigmentary retinal deposits. Auditory toxicity was characterized by a mid- to high-frequency neurosensorial hearing loss and the lesion was of the cochlear type. /"Desferrioxamine"/ withdrawal resulted in a complete recovery of visual function in 1 patient and partial recovery in 3, and a complete reversal of /"hearing loss"/ in 3 patients and partial recovery in 3. This toxicity appeared in patients receiving the higher doses of /"desferrioxamine"/ or coincided with the normalization of ferritin or aluminium serum levels. The data indicate that audiovisual toxicity is not an infrequent complication in hemodialyzed patients receiving /"desferrioxamine"/. Periodical audiovisual monitoring should be performed on hemodialyzed patients receiving the drug in order to detect adverse effects as early as possible. Question: Does chemical /"desferrioxamine"/ induce disease /"hearing loss"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"magnesium"/ induces disease /"Myasthenia gravis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Myasthenia gravis"/ presenting as weakness after /"magnesium"/ administration. - Abstract: We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral /"magnesium"/ administration for preeclampsia. The serum /"magnesium"/ concentration was 3.0 mEq/L, which is usually well tolerated. The /"magnesium"/ was stopped and she recovered over a few days. While she was weak, 2-Hz repetitive stimulation revealed a decrement without significant facilitation at rapid rates or after exercise, suggesting postsynaptic neuromuscular blockade. After her strength returned, repetitive stimulation was normal, but single fiber EMG revealed increased jitter and blocking. Her acetylcholine receptor antibody level was markedly elevated. Although paralysis after /"magnesium"/ administration has been described in patients with known /"myasthenia gravis"/, it has not previously been reported to be the initial or only manifestation of the disease. Patients who are unusually sensitive to the neuromuscular effects of /"magnesium"/ should be suspected of having an underlying disorder of neuromuscular transmission. Question: Does chemical /"magnesium"/ induce disease /"Myasthenia gravis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"acetylcholine"/ induces disease /"paralysis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Myasthenia gravis presenting as weakness after magnesium administration. - Abstract: We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentration was 3.0 mEq/L, which is usually well tolerated. The magnesium was stopped and she recovered over a few days. While she was weak, 2-Hz repetitive stimulation revealed a decrement without significant facilitation at rapid rates or after exercise, suggesting postsynaptic neuromuscular blockade. After her strength returned, repetitive stimulation was normal, but single fiber EMG revealed increased jitter and blocking. Her /"acetylcholine"/ receptor antibody level was markedly elevated. Although /"paralysis"/ after magnesium administration has been described in patients with known myasthenia gravis, it has not previously been reported to be the initial or only manifestation of the disease. Patients who are unusually sensitive to the neuromuscular effects of magnesium should be suspected of having an underlying disorder of neuromuscular transmission. Question: Does chemical /"acetylcholine"/ induce disease /"paralysis"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Chloroacetaldehyde"/ induces disease /"hemorrhagic cystitis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Chloroacetaldehyde"/ and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication. - Abstract: Based on clinical data, indicating that /"chloroacetaldehyde"/ (/"CAA"/) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of /"CAA"/ in the development of /"hemorrhagic cystitis"/. The data demonstrate that /"CAA"/ after i.v. administration does not contribute to bladder damage. When instilled directly into the bladder, /"CAA"/ exerts urotoxic effects, it is, however, susceptible to detoxification with mesna. Question: Does chemical /"Chloroacetaldehyde"/ induce disease /"hemorrhagic cystitis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Chloroacetaldehyde"/ induces disease /"cystitis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Chloroacetaldehyde"/ and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication. - Abstract: Based on clinical data, indicating that /"chloroacetaldehyde"/ (/"CAA"/) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of /"CAA"/ in the development of hemorrhagic /"cystitis"/. The data demonstrate that /"CAA"/ after i.v. administration does not contribute to bladder damage. When instilled directly into the bladder, /"CAA"/ exerts urotoxic effects, it is, however, susceptible to detoxification with mesna. Question: Does chemical /"Chloroacetaldehyde"/ induce disease /"cystitis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Chloroacetaldehyde"/ induces disease /"hemorrhagic"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Chloroacetaldehyde"/ and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication. - Abstract: Based on clinical data, indicating that /"chloroacetaldehyde"/ (/"CAA"/) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of /"CAA"/ in the development of /"hemorrhagic"/ cystitis. The data demonstrate that /"CAA"/ after i.v. administration does not contribute to bladder damage. When instilled directly into the bladder, /"CAA"/ exerts urotoxic effects, it is, however, susceptible to detoxification with mesna. Question: Does chemical /"Chloroacetaldehyde"/ induce disease /"hemorrhagic"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Chloroacetaldehyde"/ induces disease /"bladder damage"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Chloroacetaldehyde"/ and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication. - Abstract: Based on clinical data, indicating that /"chloroacetaldehyde"/ (/"CAA"/) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of /"CAA"/ in the development of hemorrhagic cystitis. The data demonstrate that /"CAA"/ after i.v. administration does not contribute to /"bladder damage"/. When instilled directly into the bladder, /"CAA"/ exerts urotoxic effects, it is, however, susceptible to detoxification with mesna. Question: Does chemical /"Chloroacetaldehyde"/ induce disease /"bladder damage"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"ifosfamide"/ induces disease /"bladder damage"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or /"ifosfamide"/. An experimental study/short communication. - Abstract: Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of CAA in the development of hemorrhagic cystitis. The data demonstrate that CAA after i.v. administration does not contribute to /"bladder damage"/. When instilled directly into the bladder, CAA exerts urotoxic effects, it is, however, susceptible to detoxification with mesna. Question: Does chemical /"ifosfamide"/ induce disease /"bladder damage"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"mesna"/ induces disease /"hemorrhagic"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication. - Abstract: Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of CAA in the development of /"hemorrhagic"/ cystitis. The data demonstrate that CAA after i.v. administration does not contribute to bladder damage. When instilled directly into the bladder, CAA exerts urotoxic effects, it is, however, susceptible to detoxification with /"mesna"/. Question: Does chemical /"mesna"/ induce disease /"hemorrhagic"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"nitroglycerin"/ induces disease /"migraine"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Source of pain and primitive dysfunction in /"migraine"/: an identical site? - Abstract: Twenty common /"migraine"/ patients received a one sided frontotemporal application of /"nitroglycerin"/ (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset /"migraine"/ attacks were induced by /"nitroglycerin"/ in seven out of 10 patients versus no patient in the placebo group. Subsequently 20 /"migraine"/ patients, who developed an early onset attack with frontotemporal /"nitroglycerin"/, received the drug in a second induction test at other body areas. No early onset /"migraine"/ was observed. Thus the /"migraine"/-inducing effect of /"nitroglycerin"/ seems to depend on direct stimulation of the habitual site of pain, suggesting that the frontotemporal region is of crucial importance in the development of a /"migraine"/ crisis. This is not consistent with a CNS origin of /"migraine"/ attack. Question: Does chemical /"nitroglycerin"/ induce disease /"migraine"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"nitroglycerin"/ induces disease /"pain"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Source of /"pain"/ and primitive dysfunction in migraine: an identical site? - Abstract: Twenty common migraine patients received a one sided frontotemporal application of /"nitroglycerin"/ (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset migraine attacks were induced by /"nitroglycerin"/ in seven out of 10 patients versus no patient in the placebo group. Subsequently 20 migraine patients, who developed an early onset attack with frontotemporal /"nitroglycerin"/, received the drug in a second induction test at other body areas. No early onset migraine was observed. Thus the migraine-inducing effect of /"nitroglycerin"/ seems to depend on direct stimulation of the habitual site of /"pain"/, suggesting that the frontotemporal region is of crucial importance in the development of a migraine crisis. This is not consistent with a CNS origin of migraine attack. Question: Does chemical /"nitroglycerin"/ induce disease /"pain"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Clotiazepam"/ induces disease /"hepatitis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Clotiazepam"/-induced acute /"hepatitis"/. - Abstract: We report the case of a patient who developed acute /"hepatitis"/ with extensive hepatocellular necrosis, 7 months after the onset of administration of /"clotiazepam"/, a thienodiazepine derivative. /"Clotiazepam"/ withdrawal was followed by prompt recovery. The administration of several benzodiazepines, chemically related to /"clotiazepam"/, did not interfere with recovery and did not induce any relapse of /"hepatitis"/. This observation shows that /"clotiazepam"/ can induce acute /"hepatitis"/ and suggests that there is no cross /"hepatotoxicity"/ between /"clotiazepam"/ and several benzodiazepines. Question: Does chemical /"Clotiazepam"/ induce disease /"hepatitis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"benzodiazepines"/ induces disease /"hepatitis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Clotiazepam-induced acute /"hepatitis"/. - Abstract: We report the case of a patient who developed acute /"hepatitis"/ with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recovery. The administration of several /"benzodiazepines"/, chemically related to clotiazepam, did not interfere with recovery and did not induce any relapse of /"hepatitis"/. This observation shows that clotiazepam can induce acute /"hepatitis"/ and suggests that there is no cross /"hepatotoxicity"/ between clotiazepam and several /"benzodiazepines"/. Question: Does chemical /"benzodiazepines"/ induce disease /"hepatitis"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"ketoconazole"/ induces disease /"hypertension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Arterial /"hypertension"/ as a complication of prolonged /"ketoconazole"/ treatment. - Abstract: Two of 14 patients with Cushing's syndrome treated on a long-term basis with /"ketoconazole"/ developed sustained /"hypertension"/. In both cases normal plasma and urinary free cortisol levels had been achieved following /"ketoconazole"/ therapy, yet continuous blood pressure monitoring demonstrated /"hypertension"/ 31 (patient 1) and 52 weeks (patient 2) after treatment. In patient 1, plasma levels of deoxycorticosterone and 11-deoxycortisol were elevated. In patient 2, in addition to an increase in both deoxycorticosterone and 11-deoxycortisol levels, plasma aldosterone values were raised, with a concomitant suppression of renin levels. Our findings show that long-term treatment with high doses of /"ketoconazole"/ may induce enzyme blockade leading to mineralocorticoid-related /"hypertension"/. Question: Does chemical /"ketoconazole"/ induce disease /"hypertension"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"aldosterone"/ induces disease /"hypertension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Arterial /"hypertension"/ as a complication of prolonged ketoconazole treatment. - Abstract: Two of 14 patients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustained /"hypertension"/. In both cases normal plasma and urinary free cortisol levels had been achieved following ketoconazole therapy, yet continuous blood pressure monitoring demonstrated /"hypertension"/ 31 (patient 1) and 52 weeks (patient 2) after treatment. In patient 1, plasma levels of deoxycorticosterone and 11-deoxycortisol were elevated. In patient 2, in addition to an increase in both deoxycorticosterone and 11-deoxycortisol levels, plasma /"aldosterone"/ values were raised, with a concomitant suppression of renin levels. Our findings show that long-term treatment with high doses of ketoconazole may induce enzyme blockade leading to mineralocorticoid-related /"hypertension"/. Question: Does chemical /"aldosterone"/ induce disease /"hypertension"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"tranexamic acid"/ induces disease /"intravascular coagulation"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to /"intravascular coagulation"/ in the rat. - Abstract: Induction of /"intravascular coagulation"/ and inhibition of fibrinolysis by injection of thrombin and /"tranexamic acid"/ (/"AMCA"/) in the rat gives rise to pulmonary and renal insufficiency resembling that occurring after trauma or sepsis in man. Injection of Captopril (1 mg/kg), an inhibitor of angiotensin converting enzyme (ACE), reduced both pulmonary and renal insufficiency in this rat model. The lung weights were lower and PaO2 was improved in rats given this enzyme-blocking agent. The contents of albumin in the lungs were not changed, indicating that Captopril did not influence the extravasation of protein. Renal damage as reflected by an increase in serum urea and in kidney weight was prevented by Captopril. The amount of fibrin in the kidneys was also considerably lower than in animals which received thrombin and /"AMCA"/ alone. It is suggested that the effects of Captopril on the lungs may be attributable to a vasodilatory effect due to a reduction in the circulating level of Angiotension II and an increase in prostacyclin (secondary to an increase in bradykinin). Captopril may, by the same mechanism, reduce the increase in glomerular filtration that is known to occur after an injection of thrombin, thereby diminishing the aggregation of fibrin monomers in the glomeruli, with the result that less fibrin will be deposited and thus less kidney damage will be produced. Question: Does chemical /"tranexamic acid"/ induce disease /"intravascular coagulation"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"angiotensin"/ induces disease /"trauma"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Effects of an inhibitor of /"angiotensin"/ converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat. - Abstract: Induction of intravascular coagulation and inhibition of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficiency resembling that occurring after /"trauma"/ or sepsis in man. Injection of Captopril (1 mg/kg), an inhibitor of /"angiotensin"/ converting enzyme (ACE), reduced both pulmonary and renal insufficiency in this rat model. The lung weights were lower and PaO2 was improved in rats given this enzyme-blocking agent. The contents of albumin in the lungs were not changed, indicating that Captopril did not influence the extravasation of protein. Renal damage as reflected by an increase in serum urea and in kidney weight was prevented by Captopril. The amount of fibrin in the kidneys was also considerably lower than in animals which received thrombin and AMCA alone. It is suggested that the effects of Captopril on the lungs may be attributable to a vasodilatory effect due to a reduction in the circulating level of Angiotension II and an increase in prostacyclin (secondary to an increase in bradykinin). Captopril may, by the same mechanism, reduce the increase in glomerular filtration that is known to occur after an injection of thrombin, thereby diminishing the aggregation of fibrin monomers in the glomeruli, with the result that less fibrin will be deposited and thus less kidney damage will be produced. Question: Does chemical /"angiotensin"/ induce disease /"trauma"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"nitroprusside"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: A randomized comparison of labetalol and /"nitroprusside"/ for induced /"hypotension"/. - Abstract: In a randomized study, labetalol-induced /"hypotension"/ and /"nitroprusside"/-induced /"hypotension"/ were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic protocol and similar drug-induced /"reductions in mean arterial blood pressure"/ (BP) (50 to 55 mmHg). Nitroprusside infusion was associated with a significant (p less than 0.05) increase in heart rate and cardiac output; rebound hypertension was observed in three patients after discontinuation of /"nitroprusside"/. Labetalol administration was not associated with any of these findings. Arterial PO2 decreased in both groups. It was concluded that labetalol offers advantages over /"nitroprusside"/. Question: Does chemical /"nitroprusside"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"nitroprusside"/ induces disease /"increase in heart rate and cardiac output"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: A randomized comparison of labetalol and /"nitroprusside"/ for induced hypotension. - Abstract: In a randomized study, labetalol-induced hypotension and /"nitroprusside"/-induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic protocol and similar drug-induced reductions in mean arterial blood pressure (BP) (50 to 55 mmHg). Nitroprusside infusion was associated with a significant (p less than 0.05) /"increase in heart rate and cardiac output"/; rebound hypertension was observed in three patients after discontinuation of /"nitroprusside"/. Labetalol administration was not associated with any of these findings. Arterial PO2 decreased in both groups. It was concluded that labetalol offers advantages over /"nitroprusside"/. Question: Does chemical /"nitroprusside"/ induce disease /"increase in heart rate and cardiac output"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"labetalol"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: A randomized comparison of /"labetalol"/ and nitroprusside for induced /"hypotension"/. - Abstract: In a randomized study, /"labetalol"/-induced /"hypotension"/ and nitroprusside-induced /"hypotension"/ were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic protocol and similar drug-induced /"reductions in mean arterial blood pressure"/ (BP) (50 to 55 mmHg). Nitroprusside infusion was associated with a significant (p less than 0.05) increase in heart rate and cardiac output; rebound hypertension was observed in three patients after discontinuation of nitroprusside. /"Labetalol"/ administration was not associated with any of these findings. Arterial PO2 decreased in both groups. It was concluded that /"labetalol"/ offers advantages over nitroprusside. Question: Does chemical /"labetalol"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"PO2"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: A randomized comparison of labetalol and nitroprusside for induced /"hypotension"/. - Abstract: In a randomized study, labetalol-induced /"hypotension"/ and nitroprusside-induced /"hypotension"/ were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic protocol and similar drug-induced /"reductions in mean arterial blood pressure"/ (BP) (50 to 55 mmHg). Nitroprusside infusion was associated with a significant (p less than 0.05) increase in heart rate and cardiac output; rebound hypertension was observed in three patients after discontinuation of nitroprusside. Labetalol administration was not associated with any of these findings. Arterial /"PO2"/ decreased in both groups. It was concluded that labetalol offers advantages over nitroprusside. Question: Does chemical /"PO2"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"labetalol"/ induces disease /"increase in heart rate and cardiac output"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: A randomized comparison of /"labetalol"/ and nitroprusside for induced hypotension. - Abstract: In a randomized study, /"labetalol"/-induced hypotension and nitroprusside-induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic protocol and similar drug-induced reductions in mean arterial blood pressure (BP) (50 to 55 mmHg). Nitroprusside infusion was associated with a significant (p less than 0.05) /"increase in heart rate and cardiac output"/; rebound hypertension was observed in three patients after discontinuation of nitroprusside. /"Labetalol"/ administration was not associated with any of these findings. Arterial PO2 decreased in both groups. It was concluded that /"labetalol"/ offers advantages over nitroprusside. Question: Does chemical /"labetalol"/ induce disease /"increase in heart rate and cardiac output"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"PO2"/ induces disease /"hypertension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: A randomized comparison of labetalol and nitroprusside for induced hypotension. - Abstract: In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic protocol and similar drug-induced reductions in mean arterial blood pressure (BP) (50 to 55 mmHg). Nitroprusside infusion was associated with a significant (p less than 0.05) increase in heart rate and cardiac output; rebound /"hypertension"/ was observed in three patients after discontinuation of nitroprusside. Labetalol administration was not associated with any of these findings. Arterial /"PO2"/ decreased in both groups. It was concluded that labetalol offers advantages over nitroprusside. Question: Does chemical /"PO2"/ induce disease /"hypertension"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"hexafluorodiethyl ether"/ induces disease /"seizures"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations. - Abstract: Folate depletion has often been a problem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical studies. A rat model was developed to examine the effects of chronic CBZ treatment on folate concentrations in the rat. In the course of developing this model, a common vehicle, propylene glycol, by itself in high doses, was found to exhibit protective properties against induced /"seizures"/ and inhibited weight gain. /"Seizures"/ induced by /"hexafluorodiethyl ether"/ (/"HFDE"/) were also found to be a more sensitive measure of protection by CBZ than /"seizures"/ induced by maximal electroshock (MES). Oral administration of CBZ as an aqueous suspension every 8 h at a dose of 250 mg/kg was continuously protective against /"HFDE"/-induced /"seizures"/ and was minimally toxic as measured by weight gain over 8 weeks of treatment. The CBZ levels measured in plasma and brain of these animals, however, were below those normally considered protective. This treatment with CBZ had no apparent adverse effect on folate concentrations in the rat, and, indeed, the folate concentration increased in liver after 6 weeks of treatment and in plasma at 8 weeks of treatment. Question: Does chemical /"hexafluorodiethyl ether"/ induce disease /"seizures"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"propylene glycol"/ induces disease /"weight gain"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations. - Abstract: Folate depletion has often been a problem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical studies. A rat model was developed to examine the effects of chronic CBZ treatment on folate concentrations in the rat. In the course of developing this model, a common vehicle, /"propylene glycol"/, by itself in high doses, was found to exhibit protective properties against induced seizures and inhibited /"weight gain"/. Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be a more sensitive measure of protection by CBZ than seizures induced by maximal electroshock (MES). Oral administration of CBZ as an aqueous suspension every 8 h at a dose of 250 mg/kg was continuously protective against HFDE-induced seizures and was minimally toxic as measured by /"weight gain"/ over 8 weeks of treatment. The CBZ levels measured in plasma and brain of these animals, however, were below those normally considered protective. This treatment with CBZ had no apparent adverse effect on folate concentrations in the rat, and, indeed, the folate concentration increased in liver after 6 weeks of treatment and in plasma at 8 weeks of treatment. Question: Does chemical /"propylene glycol"/ induce disease /"weight gain"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"nitroglycerin"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Inhibition of sympathoadrenal activity by atrial natriuretic factor in dogs. - Abstract: In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-atrial natriuretic factor. Mean arterial pressure (as a percentage of control +/- SEM) during randomized infusions of 0.03, 0.1, 0.3, or 1.0 microgram/kg/min was 99 +/- 1, 95 +/- 1 (p less than 0.05), 93 +/- 1 (p less than 0.01), or 79 +/- 6% (p less than 0.001), respectively, but no tachycardia and no augmentation of the norepinephrine release rate (up to 0.3 microgram/kg/min) were observed, which is in contrast to comparable /"hypotension"/ induced by hydralazine or /"nitroglycerin"/. The release rate of epinephrine (control, 6.7 +/- 0.6 ng/kg/min) declined immediately during infusions of atrial natriuretic factor to a minimum of 49 +/- 5% of control (p less than 0.001) during 0.1 microgram/kg/min and to 63 +/- 5% (0.1 greater than p greater than 0.05) or 95 +/- 13% (not significant) during 0.3 or 1.0 microgram/kg/min. Steady state arterial plasma concentrations of atrial natriuretic factor were 39 +/- 10 pg/ml (n = 6) during infusions of saline and 284 +/- 24 pg/ml (n = 6) and 1520 +/- 300 pg/ml (n = 9) during 0.03 and 0.1 microgram/kg/min infusions of the factor.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"nitroglycerin"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"hydralazine"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Inhibition of sympathoadrenal activity by atrial natriuretic factor in dogs. - Abstract: In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-atrial natriuretic factor. Mean arterial pressure (as a percentage of control +/- SEM) during randomized infusions of 0.03, 0.1, 0.3, or 1.0 microgram/kg/min was 99 +/- 1, 95 +/- 1 (p less than 0.05), 93 +/- 1 (p less than 0.01), or 79 +/- 6% (p less than 0.001), respectively, but no tachycardia and no augmentation of the norepinephrine release rate (up to 0.3 microgram/kg/min) were observed, which is in contrast to comparable /"hypotension"/ induced by /"hydralazine"/ or nitroglycerin. The release rate of epinephrine (control, 6.7 +/- 0.6 ng/kg/min) declined immediately during infusions of atrial natriuretic factor to a minimum of 49 +/- 5% of control (p less than 0.001) during 0.1 microgram/kg/min and to 63 +/- 5% (0.1 greater than p greater than 0.05) or 95 +/- 13% (not significant) during 0.3 or 1.0 microgram/kg/min. Steady state arterial plasma concentrations of atrial natriuretic factor were 39 +/- 10 pg/ml (n = 6) during infusions of saline and 284 +/- 24 pg/ml (n = 6) and 1520 +/- 300 pg/ml (n = 9) during 0.03 and 0.1 microgram/kg/min infusions of the factor.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"hydralazine"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"norepinephrine"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Inhibition of sympathoadrenal activity by atrial natriuretic factor in dogs. - Abstract: In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed as the release rate of /"norepinephrine"/ and epinephrine during 15-minute i.v. infusions of human alpha-atrial natriuretic factor. Mean arterial pressure (as a percentage of control +/- SEM) during randomized infusions of 0.03, 0.1, 0.3, or 1.0 microgram/kg/min was 99 +/- 1, 95 +/- 1 (p less than 0.05), 93 +/- 1 (p less than 0.01), or 79 +/- 6% (p less than 0.001), respectively, but no tachycardia and no augmentation of the /"norepinephrine"/ release rate (up to 0.3 microgram/kg/min) were observed, which is in contrast to comparable /"hypotension"/ induced by hydralazine or nitroglycerin. The release rate of epinephrine (control, 6.7 +/- 0.6 ng/kg/min) declined immediately during infusions of atrial natriuretic factor to a minimum of 49 +/- 5% of control (p less than 0.001) during 0.1 microgram/kg/min and to 63 +/- 5% (0.1 greater than p greater than 0.05) or 95 +/- 13% (not significant) during 0.3 or 1.0 microgram/kg/min. Steady state arterial plasma concentrations of atrial natriuretic factor were 39 +/- 10 pg/ml (n = 6) during infusions of saline and 284 +/- 24 pg/ml (n = 6) and 1520 +/- 300 pg/ml (n = 9) during 0.03 and 0.1 microgram/kg/min infusions of the factor.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"norepinephrine"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"nitroglycerin"/ induces disease /"tachycardia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Inhibition of sympathoadrenal activity by atrial natriuretic factor in dogs. - Abstract: In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-atrial natriuretic factor. Mean arterial pressure (as a percentage of control +/- SEM) during randomized infusions of 0.03, 0.1, 0.3, or 1.0 microgram/kg/min was 99 +/- 1, 95 +/- 1 (p less than 0.05), 93 +/- 1 (p less than 0.01), or 79 +/- 6% (p less than 0.001), respectively, but no /"tachycardia"/ and no augmentation of the norepinephrine release rate (up to 0.3 microgram/kg/min) were observed, which is in contrast to comparable hypotension induced by hydralazine or /"nitroglycerin"/. The release rate of epinephrine (control, 6.7 +/- 0.6 ng/kg/min) declined immediately during infusions of atrial natriuretic factor to a minimum of 49 +/- 5% of control (p less than 0.001) during 0.1 microgram/kg/min and to 63 +/- 5% (0.1 greater than p greater than 0.05) or 95 +/- 13% (not significant) during 0.3 or 1.0 microgram/kg/min. Steady state arterial plasma concentrations of atrial natriuretic factor were 39 +/- 10 pg/ml (n = 6) during infusions of saline and 284 +/- 24 pg/ml (n = 6) and 1520 +/- 300 pg/ml (n = 9) during 0.03 and 0.1 microgram/kg/min infusions of the factor.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"nitroglycerin"/ induce disease /"tachycardia"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Etoposide"/ induces disease /"pulmonary obstruction"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Death from chemotherapy in gestational trophoblastic disease. - Abstract: Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was treated with multiple cytotoxic drugs. The multiple drug schema consisted of: /"Etoposide"/ 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day of the schedule, moderate high doses of Methotrexate, /"Etoposide"/ and Cyclophosphamide were administered. Within 8 hours after initiation of therapy the patient died with a clinical picture resembling massive /"pulmonary obstruction"/ due to choriocarcinomic tissue plugs, probably originating from the uterus. Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, which resulted in an open exchange of tumor plugs to the vascular spaces; decrease in tumor tissue coherence secondary to chemotherapy may have further contributed to the formation of tumor emboli. In view of the close time association between the start of chemotherapy and the acute onset of massive embolism other explanations, such as spontaneous necrosis, must be considered less likely. Patients with large pelvic tumor loads are, according to existing classifications, at high risk to die and to develop drug resistance. Notwithstanding these facts our findings suggest that these patients might benefit from relatively mild initial treatment, especially true for patients not previously exposed to this drug. Close observation of the response status both clinically and with beta-hCG values may indicate whether and when more agressive combination chemotherapy should be started.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"Etoposide"/ induce disease /"pulmonary obstruction"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Methotrexate"/ induces disease /"pulmonary obstruction"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Death from chemotherapy in gestational trophoblastic disease. - Abstract: Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was treated with multiple cytotoxic drugs. The multiple drug schema consisted of: Etoposide 16.213, /"Methotrexate"/, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day of the schedule, moderate high doses of /"Methotrexate"/, Etoposide and Cyclophosphamide were administered. Within 8 hours after initiation of therapy the patient died with a clinical picture resembling massive /"pulmonary obstruction"/ due to choriocarcinomic tissue plugs, probably originating from the uterus. Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, which resulted in an open exchange of tumor plugs to the vascular spaces; decrease in tumor tissue coherence secondary to chemotherapy may have further contributed to the formation of tumor emboli. In view of the close time association between the start of chemotherapy and the acute onset of massive embolism other explanations, such as spontaneous necrosis, must be considered less likely. Patients with large pelvic tumor loads are, according to existing classifications, at high risk to die and to develop drug resistance. Notwithstanding these facts our findings suggest that these patients might benefit from relatively mild initial treatment, especially true for patients not previously exposed to this drug. Close observation of the response status both clinically and with beta-hCG values may indicate whether and when more agressive combination chemotherapy should be started.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"Methotrexate"/ induce disease /"pulmonary obstruction"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Cyclophosphamide"/ induces disease /"pulmonary obstruction"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Death from chemotherapy in gestational trophoblastic disease. - Abstract: Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was treated with multiple cytotoxic drugs. The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, /"Cyclophosphamide"/, Actomycin-D, and Cisplatin. On the first day of the schedule, moderate high doses of Methotrexate, Etoposide and /"Cyclophosphamide"/ were administered. Within 8 hours after initiation of therapy the patient died with a clinical picture resembling massive /"pulmonary obstruction"/ due to choriocarcinomic tissue plugs, probably originating from the uterus. Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, which resulted in an open exchange of tumor plugs to the vascular spaces; decrease in tumor tissue coherence secondary to chemotherapy may have further contributed to the formation of tumor emboli. In view of the close time association between the start of chemotherapy and the acute onset of massive embolism other explanations, such as spontaneous necrosis, must be considered less likely. Patients with large pelvic tumor loads are, according to existing classifications, at high risk to die and to develop drug resistance. Notwithstanding these facts our findings suggest that these patients might benefit from relatively mild initial treatment, especially true for patients not previously exposed to this drug. Close observation of the response status both clinically and with beta-hCG values may indicate whether and when more agressive combination chemotherapy should be started.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"Cyclophosphamide"/ induce disease /"pulmonary obstruction"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Actomycin-D"/ induces disease /"embolism"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Death from chemotherapy in gestational trophoblastic disease. - Abstract: Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was treated with multiple cytotoxic drugs. The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, /"Actomycin-D"/, and Cisplatin. On the first day of the schedule, moderate high doses of Methotrexate, Etoposide and Cyclophosphamide were administered. Within 8 hours after initiation of therapy the patient died with a clinical picture resembling massive pulmonary obstruction due to choriocarcinomic tissue plugs, probably originating from the uterus. Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, which resulted in an open exchange of tumor plugs to the vascular spaces; decrease in tumor tissue coherence secondary to chemotherapy may have further contributed to the formation of tumor emboli. In view of the close time association between the start of chemotherapy and the acute onset of massive /"embolism"/ other explanations, such as spontaneous necrosis, must be considered less likely. Patients with large pelvic tumor loads are, according to existing classifications, at high risk to die and to develop drug resistance. Notwithstanding these facts our findings suggest that these patients might benefit from relatively mild initial treatment, especially true for patients not previously exposed to this drug. Close observation of the response status both clinically and with beta-hCG values may indicate whether and when more agressive combination chemotherapy should be started.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"Actomycin-D"/ induce disease /"embolism"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Etoposide"/ induces disease /"tumor"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Death from chemotherapy in gestational trophoblastic disease. - Abstract: Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was treated with multiple cytotoxic drugs. The multiple drug schema consisted of: /"Etoposide"/ 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day of the schedule, moderate high doses of Methotrexate, /"Etoposide"/ and Cyclophosphamide were administered. Within 8 hours after initiation of therapy the patient died with a clinical picture resembling massive pulmonary obstruction due to choriocarcinomic tissue plugs, probably originating from the uterus. Formation of these plugs was probably due to extensive /"tumor"/ necrosis at the level of the walls of the major uterine veins, which resulted in an open exchange of /"tumor"/ plugs to the vascular spaces; decrease in /"tumor"/ tissue coherence secondary to chemotherapy may have further contributed to the formation of /"tumor"/ emboli. In view of the close time association between the start of chemotherapy and the acute onset of massive embolism other explanations, such as spontaneous necrosis, must be considered less likely. Patients with large pelvic tumor loads are, according to existing classifications, at high risk to die and to develop drug resistance. Notwithstanding these facts our findings suggest that these patients might benefit from relatively mild initial treatment, especially true for patients not previously exposed to this drug. Close observation of the response status both clinically and with beta-hCG values may indicate whether and when more agressive combination chemotherapy should be started.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"Etoposide"/ induce disease /"tumor"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Etoposide"/ induces disease /"embolism"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Death from chemotherapy in gestational trophoblastic disease. - Abstract: Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was treated with multiple cytotoxic drugs. The multiple drug schema consisted of: /"Etoposide"/ 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day of the schedule, moderate high doses of Methotrexate, /"Etoposide"/ and Cyclophosphamide were administered. Within 8 hours after initiation of therapy the patient died with a clinical picture resembling massive pulmonary obstruction due to choriocarcinomic tissue plugs, probably originating from the uterus. Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, which resulted in an open exchange of tumor plugs to the vascular spaces; decrease in tumor tissue coherence secondary to chemotherapy may have further contributed to the formation of tumor emboli. In view of the close time association between the start of chemotherapy and the acute onset of massive /"embolism"/ other explanations, such as spontaneous necrosis, must be considered less likely. Patients with large pelvic tumor loads are, according to existing classifications, at high risk to die and to develop drug resistance. Notwithstanding these facts our findings suggest that these patients might benefit from relatively mild initial treatment, especially true for patients not previously exposed to this drug. Close observation of the response status both clinically and with beta-hCG values may indicate whether and when more agressive combination chemotherapy should be started.(ABSTRACT TRUNCATED AT 250 WORDS) Question: Does chemical /"Etoposide"/ induce disease /"embolism"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"methotrexate"/ induces disease /"Impotence"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Sexual dysfunction among patients with arthritis. - Abstract: The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-matched to controls. Assessments of marital happiness and depressed mood were also made using the CES-D and the Azrin Marital Happiness Scale (AMHS). Sexual dysfunctions were found to be common among patients and controls, the majority in both groups reporting one or more dysfunctions. /"Impotence"/ was more common among male patients than controls and was found to be associated with co-morbidity and the taking of /"methotrexate"/. Depressed mood was more common among patients and was associated with certain sexual difficulties, but not with /"impotence"/. Marital unhappiness, as indicated by AMHS scores, was not associated with arthritis but was associated with sexual dysfunction, sexual dissatisfaction and being female. Question: Does chemical /"methotrexate"/ induce disease /"Impotence"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"methotrexate"/ induces disease /"osteoarthritis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Sexual dysfunction among patients with arthritis. - Abstract: The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, /"osteoarthritis"/ and spondyloarthropathy, 130 of whom were pair-matched to controls. Assessments of marital happiness and depressed mood were also made using the CES-D and the Azrin Marital Happiness Scale (AMHS). Sexual dysfunctions were found to be common among patients and controls, the majority in both groups reporting one or more dysfunctions. Impotence was more common among male patients than controls and was found to be associated with co-morbidity and the taking of /"methotrexate"/. Depressed mood was more common among patients and was associated with certain sexual difficulties, but not with impotence. Marital unhappiness, as indicated by AMHS scores, was not associated with arthritis but was associated with sexual dysfunction, sexual dissatisfaction and being female. Question: Does chemical /"methotrexate"/ induce disease /"osteoarthritis"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"phenacetin"/ induces disease /"renal papillary necrosis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Does paracetamol cause urothelial cancer or /"renal papillary necrosis"/? - Abstract: The risk of developing /"renal papillary necrosis"/ or cancer of the renal pelvis, ureter or bladder associated with consumption of either /"phenacetin"/ or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of /"renal papillary necrosis"/ was increased nearly 20-fold by consumption of /"phenacetin"/, which also increased the risk for cancer of the renal pelvis and bladder but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk from paracetamol consumption for /"renal papillary necrosis"/ or any of these cancers although there was a suggestion of an association with cancer of the ureter. Question: Does chemical /"phenacetin"/ induce disease /"renal papillary necrosis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"phenacetin"/ induces disease /"cancer of the renal pelvis, ureter or bladder"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Does paracetamol cause urothelial cancer or renal papillary necrosis? - Abstract: The risk of developing renal papillary necrosis or /"cancer of the renal pelvis, ureter or bladder"/ associated with consumption of either /"phenacetin"/ or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consumption of /"phenacetin"/, which also increased the risk for cancer of the renal pelvis and bladder but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk from paracetamol consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer of the ureter. Question: Does chemical /"phenacetin"/ induce disease /"cancer of the renal pelvis, ureter or bladder"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"phenacetin"/ induces disease /"cancer of the"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Does paracetamol cause urothelial cancer or renal papillary necrosis? - Abstract: The risk of developing renal papillary necrosis or /"cancer of the"/ renal pelvis, ureter or /"cancer of the"/ associated with consumption of either /"phenacetin"/ or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consumption of /"phenacetin"/, which also increased the risk for /"cancer of the"/ renal pelvis and /"cancer of the"/ but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk from paracetamol consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer of the ureter. Question: Does chemical /"phenacetin"/ induce disease /"cancer of the"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"phenacetin"/ induces disease /"cancer of the renal pelvis and bladder"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Does paracetamol cause urothelial cancer or renal papillary necrosis? - Abstract: The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either /"phenacetin"/ or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consumption of /"phenacetin"/, which also increased the risk for /"cancer of the renal pelvis and bladder"/ but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk from paracetamol consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer of the ureter. Question: Does chemical /"phenacetin"/ induce disease /"cancer of the renal pelvis and bladder"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"phenacetin"/ induces disease /"cancer of the renal pelvis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Does paracetamol cause urothelial cancer or renal papillary necrosis? - Abstract: The risk of developing renal papillary necrosis or /"cancer of the renal pelvis"/, ureter or bladder associated with consumption of either /"phenacetin"/ or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consumption of /"phenacetin"/, which also increased the risk for /"cancer of the renal pelvis"/ and bladder but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk from paracetamol consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer of the ureter. Question: Does chemical /"phenacetin"/ induce disease /"cancer of the renal pelvis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"paracetamol"/ induces disease /"urothelial cancer"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Does /"paracetamol"/ cause /"urothelial cancer"/ or renal papillary necrosis? - Abstract: The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or /"paracetamol"/ was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consumption of phenacetin, which also increased the risk for cancer of the renal pelvis and bladder but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk from /"paracetamol"/ consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer of the ureter. Question: Does chemical /"paracetamol"/ induce disease /"urothelial cancer"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"paracetamol"/ induces disease /"cancers"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Does /"paracetamol"/ cause urothelial cancer or renal papillary necrosis? - Abstract: The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or /"paracetamol"/ was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consumption of phenacetin, which also increased the risk for cancer of the renal pelvis and bladder but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk from /"paracetamol"/ consumption for renal papillary necrosis or any of these /"cancers"/ although there was a suggestion of an association with cancer of the ureter. Question: Does chemical /"paracetamol"/ induce disease /"cancers"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"phenacetin"/ induces disease /"urothelial cancer"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Does paracetamol cause /"urothelial cancer"/ or renal papillary necrosis? - Abstract: The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either /"phenacetin"/ or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consumption of /"phenacetin"/, which also increased the risk for cancer of the renal pelvis and bladder but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk from paracetamol consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer of the ureter. Question: Does chemical /"phenacetin"/ induce disease /"urothelial cancer"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"paracetamol"/ induces disease /"cancer of the"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Does /"paracetamol"/ cause urothelial cancer or renal papillary necrosis? - Abstract: The risk of developing renal papillary necrosis or /"cancer of the"/ renal pelvis, /"cancer of the"/ or bladder associated with consumption of either phenacetin or /"paracetamol"/ was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consumption of phenacetin, which also increased the risk for cancer of the renal pelvis and bladder but not for /"ureteric cancer"/. By contrast, we were unable to substantiate an increased risk from /"paracetamol"/ consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with /"cancer of the ureter"/. Question: Does chemical /"paracetamol"/ induce disease /"cancer of the"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"paracetamol"/ induces disease /"cancer of the renal pelvis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Does /"paracetamol"/ cause urothelial cancer or renal papillary necrosis? - Abstract: The risk of developing renal papillary necrosis or /"cancer of the renal pelvis"/, ureter or bladder associated with consumption of either phenacetin or /"paracetamol"/ was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consumption of phenacetin, which also increased the risk for /"cancer of the renal pelvis"/ and bladder but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk from /"paracetamol"/ consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer of the ureter. Question: Does chemical /"paracetamol"/ induce disease /"cancer of the renal pelvis"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Dapsone"/ induces disease /"hemolytic anemia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Dapsone"/-associated Heinz body /"hemolytic anemia"/ in a Cambodian woman with hemoglobin E trait. - Abstract: A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body /"hemolytic anemia"/ while taking a dose of /"dapsone"/ (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH stability. The pentose phosphate shunt activity of the /"dapsone"/-exposed AE RBCs was increased compared to normal RBCs. Although the AE RBCs from an individual not taking /"dapsone"/ had increased incubated Heinz body formation, the GSH content and GSH stability were normal. The pentose phosphate shunt activity of the non-/"dapsone"/-exposed AE RBCs was decreased compared to normal RBCs. Thus, AE RBCs appear to have an increased sensitivity to oxidant stress both in vitro and in vivo, since /"dapsone"/ does not cause /"hemolytic anemia"/ at this dose in hematologically normal individuals. Given the influx of Southeast Asians into the United States, oxidant medications should be used with caution, especially if an infection is present, in individuals of ethnic backgrounds that have an increased prevalence of hemoglobin E. Question: Does chemical /"Dapsone"/ induce disease /"hemolytic anemia"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"pentose phosphate"/ induces disease /"infection"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait. - Abstract: A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH stability. The /"pentose phosphate"/ shunt activity of the dapsone-exposed AE RBCs was increased compared to normal RBCs. Although the AE RBCs from an individual not taking dapsone had increased incubated Heinz body formation, the GSH content and GSH stability were normal. The /"pentose phosphate"/ shunt activity of the non-dapsone-exposed AE RBCs was decreased compared to normal RBCs. Thus, AE RBCs appear to have an increased sensitivity to oxidant stress both in vitro and in vivo, since dapsone does not cause hemolytic anemia at this dose in hematologically normal individuals. Given the influx of Southeast Asians into the United States, oxidant medications should be used with caution, especially if an /"infection"/ is present, in individuals of ethnic backgrounds that have an increased prevalence of hemoglobin E. Question: Does chemical /"pentose phosphate"/ induce disease /"infection"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"diltiazem"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, /"diltiazem"/, and sparteine. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe /"hypotension"/, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission /"diltiazem"/ (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of metoprolol (greater than 3000 ng/ml) and /"diltiazem"/ (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of metoprolol, /"diltiazem"/, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of sparteine/debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"diltiazem"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"diltiazem"/ induces disease /"impairment of ventricular function"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, /"diltiazem"/, and sparteine. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and /"impairment of ventricular function"/. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission /"diltiazem"/ (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of metoprolol (greater than 3000 ng/ml) and /"diltiazem"/ (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of metoprolol, /"diltiazem"/, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of sparteine/debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"diltiazem"/ induce disease /"impairment of ventricular function"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"metoprolol"/ induces disease /"impairment of ventricular function"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of /"metoprolol"/, propafenone, diltiazem, and sparteine. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and /"impairment of ventricular function"/. One week prior to admission a therapy with standard doses of /"metoprolol"/ (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of /"metoprolol"/ (greater than 3000 ng/ml) and diltiazem (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of /"metoprolol"/, diltiazem, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of sparteine/debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"metoprolol"/ induce disease /"impairment of ventricular function"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"metoprolol"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of /"metoprolol"/, propafenone, diltiazem, and sparteine. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe /"hypotension"/, and impairment of ventricular function. One week prior to admission a therapy with standard doses of /"metoprolol"/ (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of /"metoprolol"/ (greater than 3000 ng/ml) and diltiazem (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of /"metoprolol"/, diltiazem, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of sparteine/debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"metoprolol"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"diltiazem"/ induces disease /"AV block"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, /"diltiazem"/, and sparteine. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. /"AV block"/, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission /"diltiazem"/ (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of metoprolol (greater than 3000 ng/ml) and /"diltiazem"/ (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of metoprolol, /"diltiazem"/, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of sparteine/debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"diltiazem"/ induce disease /"AV block"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"metoprolol"/ induces disease /"AV block"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of /"metoprolol"/, propafenone, diltiazem, and sparteine. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. /"AV block"/, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of /"metoprolol"/ (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of /"metoprolol"/ (greater than 3000 ng/ml) and diltiazem (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of /"metoprolol"/, diltiazem, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of sparteine/debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"metoprolol"/ induce disease /"AV block"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"propafenone"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, /"propafenone"/, diltiazem, and sparteine. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe /"hypotension"/, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of metoprolol (greater than 3000 ng/ml) and diltiazem (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of metoprolol, diltiazem, /"propafenone"/ (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of sparteine/debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"propafenone"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sparteine"/ induces disease /"adverse drug reactions"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and /"sparteine"/. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of metoprolol (greater than 3000 ng/ml) and diltiazem (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of metoprolol, diltiazem, propafenone (since he had received this drug in the past), and /"sparteine"/ (as a probe for the debrisoquine//"sparteine"/ type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of /"sparteine"//debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience /"adverse drug reactions"/ when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"sparteine"/ induce disease /"adverse drug reactions"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"propafenone"/ induces disease /"impairment of ventricular function"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, /"propafenone"/, diltiazem, and sparteine. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and /"impairment of ventricular function"/. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of metoprolol (greater than 3000 ng/ml) and diltiazem (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of metoprolol, diltiazem, /"propafenone"/ (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of sparteine/debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"propafenone"/ induce disease /"impairment of ventricular function"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"metoprolol"/ induces disease /"adverse drug reactions"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of /"metoprolol"/, propafenone, diltiazem, and sparteine. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of /"metoprolol"/ (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of /"metoprolol"/ (greater than 3000 ng/ml) and diltiazem (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of /"metoprolol"/, diltiazem, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of sparteine/debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience /"adverse drug reactions"/ when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"metoprolol"/ induce disease /"adverse drug reactions"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sparteine"/ induces disease /"AV block"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and /"sparteine"/. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. /"AV block"/, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of metoprolol (greater than 3000 ng/ml) and diltiazem (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of metoprolol, diltiazem, propafenone (since he had received this drug in the past), and /"sparteine"/ (as a probe for the debrisoquine//"sparteine"/ type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of /"sparteine"//debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"sparteine"/ induce disease /"AV block"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"debrisoquine"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. - Abstract: A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe /"hypotension"/, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of metoprolol (greater than 3000 ng/ml) and diltiazem (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of metoprolol, diltiazem, propafenone (since he had received this drug in the past), and sparteine (as a probe for the /"debrisoquine"//sparteine type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of sparteine//"debrisoquine"/ polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients. Question: Does chemical /"debrisoquine"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Triazolam"/ induces disease /"mania"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Triazolam"/-induced brief episodes of secondary /"mania"/ in a depressed patient. - Abstract: Large doses of /"triazolam"/ repeatedly induced brief episodes of /"mania"/ in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. /"Manic"/ excitement was coincident with the duration of action of /"triazolam"/. The possible contribution of the /"triazolo"/ group to changes in affective status is discussed. Question: Does chemical /"Triazolam"/ induce disease /"mania"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Triazolam"/ induces disease /"delirium"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Triazolam"/-induced brief episodes of secondary mania in a depressed patient. - Abstract: Large doses of /"triazolam"/ repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (/"delirium"/) were not present. Manic excitement was coincident with the duration of action of /"triazolam"/. The possible contribution of the /"triazolo"/ group to changes in affective status is discussed. Question: Does chemical /"Triazolam"/ induce disease /"delirium"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"haloperidol"/ induces disease /"muscular rigidity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: On the mechanisms of the development of tolerance to the /"muscular rigidity"/ produced by morphine in rats. - Abstract: The development of tolerance to the /"muscular rigidity"/ produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced /"rigidity"/ recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed differences in the development of tolerance: about half of the animals showed a /"rigidity"/ after the test dose of morphine that was not significantly less than in the controls and were akinetic (A group). The other rats showed a strong decrease in the /"rigidity"/ and the occurrence of stereotyped (S) licking and/or gnawing in presence of akinetic or hyperkinetic (K) behaviour (AS/KS group), suggesting signs of dopaminergic activation. The /"rigidity"/ was considerably decreased in both groups after 20 days' treatment. In a further series of experiments, /"haloperidol"/ (0.2 mg/kg i.p.) was used in order to block the dopaminergic activation and to estimate the real degree of the tolerance to the /"rigidity"/ without any dopaminergic interference. /"Haloperidol"/ enhanced the /"rigidity"/ in the A group. However, the level in the AS/KS group remained considerably lower than in the A group. The results suggest that /"rigidity"/, which is assumed to be due to an action of morphine in the striatum, can be antagonized by another process leading to dopaminergic activation in the striatum. Nevertheless, there occurs some real tolerance to this effect. The rapid alternations of /"rigidity"/ and the signs of dopaminergic activation observed in the animals of the AS/KS group might be due to rapid shifts in the predominance of various DA-innervated structures. Question: Does chemical /"haloperidol"/ induce disease /"muscular rigidity"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"morphine"/ induces disease /"muscular rigidity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: On the mechanisms of the development of tolerance to the /"muscular rigidity"/ produced by /"morphine"/ in rats. - Abstract: The development of tolerance to the /"muscular rigidity"/ produced by /"morphine"/ was studied in rats. Saline-pretreated controls given a test dose of /"morphine"/ (20 mg/kg i.p.) showed a pronounced /"rigidity"/ recorded as tonic activity in the electromyogram. Rats treated for 11 days with /"morphine"/ and withdrawn for 36-40 h showed differences in the development of tolerance: about half of the animals showed a /"rigidity"/ after the test dose of /"morphine"/ that was not significantly less than in the controls and were akinetic (A group). The other rats showed a strong decrease in the /"rigidity"/ and the occurrence of stereotyped (S) licking and/or gnawing in presence of akinetic or hyperkinetic (K) behaviour (AS/KS group), suggesting signs of dopaminergic activation. The /"rigidity"/ was considerably decreased in both groups after 20 days' treatment. In a further series of experiments, haloperidol (0.2 mg/kg i.p.) was used in order to block the dopaminergic activation and to estimate the real degree of the tolerance to the /"rigidity"/ without any dopaminergic interference. Haloperidol enhanced the /"rigidity"/ in the A group. However, the level in the AS/KS group remained considerably lower than in the A group. The results suggest that /"rigidity"/, which is assumed to be due to an action of /"morphine"/ in the striatum, can be antagonized by another process leading to dopaminergic activation in the striatum. Nevertheless, there occurs some real tolerance to this effect. The rapid alternations of /"rigidity"/ and the signs of dopaminergic activation observed in the animals of the AS/KS group might be due to rapid shifts in the predominance of various DA-innervated structures. Question: Does chemical /"morphine"/ induce disease /"muscular rigidity"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"morphine"/ induces disease /"hyperkinetic"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: On the mechanisms of the development of tolerance to the muscular rigidity produced by /"morphine"/ in rats. - Abstract: The development of tolerance to the muscular rigidity produced by /"morphine"/ was studied in rats. Saline-pretreated controls given a test dose of /"morphine"/ (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with /"morphine"/ and withdrawn for 36-40 h showed differences in the development of tolerance: about half of the animals showed a rigidity after the test dose of /"morphine"/ that was not significantly less than in the controls and were akinetic (A group). The other rats showed a strong decrease in the rigidity and the occurrence of stereotyped (S) licking and/or gnawing in presence of akinetic or /"hyperkinetic"/ (K) behaviour (AS/KS group), suggesting signs of dopaminergic activation. The rigidity was considerably decreased in both groups after 20 days' treatment. In a further series of experiments, haloperidol (0.2 mg/kg i.p.) was used in order to block the dopaminergic activation and to estimate the real degree of the tolerance to the rigidity without any dopaminergic interference. Haloperidol enhanced the rigidity in the A group. However, the level in the AS/KS group remained considerably lower than in the A group. The results suggest that rigidity, which is assumed to be due to an action of /"morphine"/ in the striatum, can be antagonized by another process leading to dopaminergic activation in the striatum. Nevertheless, there occurs some real tolerance to this effect. The rapid alternations of rigidity and the signs of dopaminergic activation observed in the animals of the AS/KS group might be due to rapid shifts in the predominance of various DA-innervated structures. Question: Does chemical /"morphine"/ induce disease /"hyperkinetic"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"morphine"/ induces disease /"akinetic"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: On the mechanisms of the development of tolerance to the muscular rigidity produced by /"morphine"/ in rats. - Abstract: The development of tolerance to the muscular rigidity produced by /"morphine"/ was studied in rats. Saline-pretreated controls given a test dose of /"morphine"/ (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with /"morphine"/ and withdrawn for 36-40 h showed differences in the development of tolerance: about half of the animals showed a rigidity after the test dose of /"morphine"/ that was not significantly less than in the controls and were /"akinetic"/ (A group). The other rats showed a strong decrease in the rigidity and the occurrence of stereotyped (S) licking and/or gnawing in presence of /"akinetic"/ or hyperkinetic (K) behaviour (AS/KS group), suggesting signs of dopaminergic activation. The rigidity was considerably decreased in both groups after 20 days' treatment. In a further series of experiments, haloperidol (0.2 mg/kg i.p.) was used in order to block the dopaminergic activation and to estimate the real degree of the tolerance to the rigidity without any dopaminergic interference. Haloperidol enhanced the rigidity in the A group. However, the level in the AS/KS group remained considerably lower than in the A group. The results suggest that rigidity, which is assumed to be due to an action of /"morphine"/ in the striatum, can be antagonized by another process leading to dopaminergic activation in the striatum. Nevertheless, there occurs some real tolerance to this effect. The rapid alternations of rigidity and the signs of dopaminergic activation observed in the animals of the AS/KS group might be due to rapid shifts in the predominance of various DA-innervated structures. Question: Does chemical /"morphine"/ induce disease /"akinetic"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"haloperidol"/ induces disease /"akinetic"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats. - Abstract: The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed differences in the development of tolerance: about half of the animals showed a rigidity after the test dose of morphine that was not significantly less than in the controls and were /"akinetic"/ (A group). The other rats showed a strong decrease in the rigidity and the occurrence of stereotyped (S) licking and/or gnawing in presence of /"akinetic"/ or hyperkinetic (K) behaviour (AS/KS group), suggesting signs of dopaminergic activation. The rigidity was considerably decreased in both groups after 20 days' treatment. In a further series of experiments, /"haloperidol"/ (0.2 mg/kg i.p.) was used in order to block the dopaminergic activation and to estimate the real degree of the tolerance to the rigidity without any dopaminergic interference. /"Haloperidol"/ enhanced the rigidity in the A group. However, the level in the AS/KS group remained considerably lower than in the A group. The results suggest that rigidity, which is assumed to be due to an action of morphine in the striatum, can be antagonized by another process leading to dopaminergic activation in the striatum. Nevertheless, there occurs some real tolerance to this effect. The rapid alternations of rigidity and the signs of dopaminergic activation observed in the animals of the AS/KS group might be due to rapid shifts in the predominance of various DA-innervated structures. Question: Does chemical /"haloperidol"/ induce disease /"akinetic"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"haloperidol"/ induces disease /"hyperkinetic"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats. - Abstract: The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed differences in the development of tolerance: about half of the animals showed a rigidity after the test dose of morphine that was not significantly less than in the controls and were akinetic (A group). The other rats showed a strong decrease in the rigidity and the occurrence of stereotyped (S) licking and/or gnawing in presence of akinetic or /"hyperkinetic"/ (K) behaviour (AS/KS group), suggesting signs of dopaminergic activation. The rigidity was considerably decreased in both groups after 20 days' treatment. In a further series of experiments, /"haloperidol"/ (0.2 mg/kg i.p.) was used in order to block the dopaminergic activation and to estimate the real degree of the tolerance to the rigidity without any dopaminergic interference. /"Haloperidol"/ enhanced the rigidity in the A group. However, the level in the AS/KS group remained considerably lower than in the A group. The results suggest that rigidity, which is assumed to be due to an action of morphine in the striatum, can be antagonized by another process leading to dopaminergic activation in the striatum. Nevertheless, there occurs some real tolerance to this effect. The rapid alternations of rigidity and the signs of dopaminergic activation observed in the animals of the AS/KS group might be due to rapid shifts in the predominance of various DA-innervated structures. Question: Does chemical /"haloperidol"/ induce disease /"hyperkinetic"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"pentazocine"/ induces disease /"fibrous myopathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Compression neuropathy of the radial nerve due to /"pentazocine"/-induced /"fibrous myopathy"/. - Abstract: /"Fibrous myopathy"/ is a common, well-known side effect of repeated /"pentazocine"/ injection. However, compression neuropathy due to fibrotic muscle affected by /"pentazocine"/-induced myopathy has not previously been reported. In a 37-year-old woman with documented /"pentazocine"/-induced /"fibrous myopathy"/ of triceps and deltoid muscles bilaterally and a three-week history of right wrist drop, electrodiagnostic examination showed a severe but partial lesion of the right radial nerve distal to the branches to the triceps, in addition to the /"fibrous myopathy"/. Surgery revealed the right radial nerve to be severely compressed by the densely fibrotic lateral head of the triceps. Decompression and neurolysis were performed with good subsequent recovery of function. Question: Does chemical /"pentazocine"/ induce disease /"fibrous myopathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"pentazocine"/ induces disease /"myopathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Compression neuropathy of the radial nerve due to /"pentazocine"/-induced fibrous myopathy. - Abstract: Fibrous myopathy is a common, well-known side effect of repeated /"pentazocine"/ injection. However, compression neuropathy due to fibrotic muscle affected by /"pentazocine"/-induced /"myopathy"/ has not previously been reported. In a 37-year-old woman with documented /"pentazocine"/-induced fibrous myopathy of triceps and deltoid muscles bilaterally and a three-week history of right wrist drop, electrodiagnostic examination showed a severe but partial lesion of the right radial nerve distal to the branches to the triceps, in addition to the fibrous myopathy. Surgery revealed the right radial nerve to be severely compressed by the densely fibrotic lateral head of the triceps. Decompression and neurolysis were performed with good subsequent recovery of function. Question: Does chemical /"pentazocine"/ induce disease /"myopathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"pentazocine"/ induces disease /"Compression neuropathy of the radial nerve"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Compression neuropathy of the radial nerve"/ due to /"pentazocine"/-induced fibrous myopathy. - Abstract: Fibrous myopathy is a common, well-known side effect of repeated /"pentazocine"/ injection. However, compression neuropathy due to fibrotic muscle affected by /"pentazocine"/-induced myopathy has not previously been reported. In a 37-year-old woman with documented /"pentazocine"/-induced fibrous myopathy of triceps and deltoid muscles bilaterally and a three-week history of right wrist drop, electrodiagnostic examination showed a severe but partial lesion of the right radial nerve distal to the branches to the triceps, in addition to the fibrous myopathy. Surgery revealed the right radial nerve to be severely compressed by the densely fibrotic lateral head of the triceps. Decompression and neurolysis were performed with good subsequent recovery of function. Question: Does chemical /"pentazocine"/ induce disease /"Compression neuropathy of the radial nerve"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"pentazocine"/ induces disease /"neuropathy of the radial nerve"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Compression /"neuropathy of the radial nerve"/ due to /"pentazocine"/-induced fibrous myopathy. - Abstract: Fibrous myopathy is a common, well-known side effect of repeated /"pentazocine"/ injection. However, compression neuropathy due to fibrotic muscle affected by /"pentazocine"/-induced myopathy has not previously been reported. In a 37-year-old woman with documented /"pentazocine"/-induced fibrous myopathy of triceps and deltoid muscles bilaterally and a three-week history of right wrist drop, electrodiagnostic examination showed a severe but partial lesion of the right radial nerve distal to the branches to the triceps, in addition to the fibrous myopathy. Surgery revealed the right radial nerve to be severely compressed by the densely fibrotic lateral head of the triceps. Decompression and neurolysis were performed with good subsequent recovery of function. Question: Does chemical /"pentazocine"/ induce disease /"neuropathy of the radial nerve"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes