PATENT ABSTRACT
Biomarkers having expression patterns that correlate with a response of cells to treatment with one or more cdk modulating agents, and uses thereof. Also provided are methods for testing or predicting whether a mammal will respond therapeutically to a method of treating cancer that comprises administering an agent that modulates cdk activity.

PATENT DESCRIPTION
SEQUENCE LISTING  
       [0001]     The present application includes a Sequence Listing. A compact disc labeled “COPY 1—SEQUENCE LISTING PART” contains the Sequence Listing as D0310 PCT.sequence listing.ST25.txt. The Sequence Listing is 13394 KB in size and was recorded on Jul. 28, 2004. The compact disc is 1 of 3 compact discs. Duplicate copies of the compact disc are labeled “COPY 2—SEQUENCE LISTING PART” and “COPY 3—SEQUENCE LISTING PART.” Also included is a computer readable form of the Sequence Listing.  
         [0002]     The compact disc and duplicate copies are identical and are hereby incorporated by reference into the present application.  
       BACKGROUND OF THE INVENTION  
       [0003]     The present invention relates generally to the field of pharmacogenomics and, more specifically, to pharmacodynamic biomarkers whose expression patterns correlate with a response of cells to treatment with one or more cdk modulating agents.  
         [0004]     Uncontrolled proliferation is a hallmark of cancer cells. Over the past two decades, it has become increasingly clear that the molecules, which directly control cell cycle progression, accumulate defects during tumorigenesis. These defects can result in the loss of checkpoint control and/or the inappropriate activation of the drivers of cell cycle progression, the cyclin-dependent kinases (referred to as “cdks” or “CDKs”). Misregulation of cdk function occurs with high frequency in major solid tumor types (including breast, colon, ovarian, prostate, and NSCL carcinomas). Therefore, inhibitors of cdks and cell cycle progression have the potential to fill a large therapeutic need.  
         [0005]     The cdks are serine/threonine protein kinases that are the driving force behind the cell cycle and cell proliferation. Cdks are multisubunit enzymes composed of at least a catalytic subunit and a regulatory (cyclin) subunit Morgan, D. O., Nature 1995; 374:131-134. To date, nine cdks (cdk1 through cdk9) and eleven cyclin subunits have been identified which can form in excess of thirteen active kinase complexes. Gould, K. L. (1994) in Protein Kinases (Woodgett, J. R., ed), pp. 149-166, Oxford University Press, Oxford. In normal cells, many of these enzymes can be categorized as G1, S, or G2/M phase enzymes which perform distinct roles in cell cycle progression. van den Heuvel, S., and Harlow, E., Science 1993; 262: 2050-2054. Cdks phosphorylate and modulate the activity of a variety of cellular proteins that include tumor suppressors (e.g., RB, p53), transcription factors (e.g., E2F-DP1, RNA pol II), replication factors (e.g., DNA pol α, replication protein A), and organizational factors which influence cellular and chromatin structures (e.g., Histone HI, lamin A, MAP4). Nigg, E. A., Trends in Cell Biology 1993; 3:296-301; Rickert, P. et al., Oncogene 1996; 12:2631-2640; Dynlacht, B. D. et al., Mol Cell Biol 1997; 17:3867-3875; Ookata, K. et al., Biochemistry 1997; 36:15873-15883.  
         [0006]     Cdk activity is regulated through a variety of co-ordinated mechanisms, which include cell cycle dependent transcription and translation, cell cycle dependent proteolysis, subcellular localization, post-translational modifications, and interaction with cdk inhibitor proteins (referred to as “CKIs”). Pines, J., and Hunter, T., Cell 1989; 58:833-846; King, R. W. et al., Science 1996; 274:1652-1659; Li, J. et al., Proc Natl Acad Sci USA 1997; 94:502-507; Draetta, G., and Beach, D., Cell 1988; 54:17-26; Harper, J. W., Cancer Surv 1997; 29:91-107. It is through these mechanisms that cell cycle checkpoints are constructed. This realization that checkpoint control is implemented through the regulation of cdk function has made the cdks and their regulatory pathways compelling targets for the development of chemotherapeutic agents. The p27/cdk2/cyclinE/RB checkpoint pathway has been clearly implicated in tumorigenesis.  
         [0007]     Numerous reports have demonstrated that both the co-activator, cyclin E, and inhibitor, p27, of cdk2 are either over-expressed or under-expressed respectively in solid tumors. Porter, P. L. et al., Nat Med 1997; 3:222-225; Kitahara, K et al., Int J Cancer 1995; 62:25-28; Wang, A. et al., J Cancer Res Clin Oncol 1996; 122:122-126; Keyomarsi, K et al., Cancer Res 1994; 54:380-385; Coinjal, F. et al. Int J Cancer 1996; 69:247-253; Akama, Y. et al., Jpn J Cancer Res 1995; 86:617-621; Tan, P. et al., Cancer Res 1997; 57:1259-1263; Catzavelos, C. et al., Nat Med 1997; 3:227-230; Fredersdorf, S. et al., Proc Natl Acad Sci USA 1997; 94:6380-6385. Their altered expression has been shown to correlate with increased cdk2 activity levels and poor prognosis.  
         [0008]     In the early clinical development of anti-cancer agents, clinical trials are typically designed to evaluate the safety, tolerability, and pharmacokinetics, as well as to identify a suitable dose and schedule for further clinical evaluation. Increasingly, there is a need to also evaluate the pharmacologic effects of novel agents in early clinical trials, particularly in cases where dosing to maximum tolerated doses may not be appropriate. As a result, there is considerable interest in identifying pharmacodynamic (PD) biomarkers that correlate with the pharmacologic modulation of a tumor target. These PD biomarkers may be tumor-specific, but ideally should also be expressed in accessible surrogate tissues such as skin or peripheral blood cells. The identification of these PD biomarkers may be carried out by analyzing changes in specific polypeptides or mRNA, as predicted by the known biology associated with the molecule targeted by the agent of interest. Alternatively, PD biomarkers can be identified by analyzing global changes in polypeptides or mRNA in cells or tissues exposed to efficacious doses of the agent. Once identified, these PD biomarkers can be used to demonstrate the desired pharmacologic modulation (e.g., inhibition) of a tumor target upon the achievement of an appropriate level of agent in the patient.  
         [0009]     There remains a need to identify biomarkers whose expression patterns correlate with a response of cells to treatment with one or more cdk modulating agents.  
         [0010]     The development of microarray technologies for large scale characterization of mRNA expression pattern has made it possible to systematically search for molecular biomarkers whose expression is modulated by drug treatment Such technologies and molecular tools have made it possible to monitor the expression level of a large number of transcripts within a cell population at any given time (see, e.g., Schena et al., 1995, Science, 270:467-470; Lockhart et al., 1996, Nature Biotechnology, 14:1675-1680; Blanchard et al., 1996, Nature Biotechnology, 14:1649; U.S. Pat. No. 5,569,588).  
       SUMMARY OF THE INVENTION  
       [0011]     The invention provides methods and procedures for determining patient sensitivity to one or more agents that modulate cyclin-dependent kinase (cdk) activity. The invention also provides methods for determining or predicting whether an individual requiring therapy for a disease state or disorder such as cancer will or will not respond to treatment, prior to administration of the treatment, wherein the treatment comprises of one or more agents that modulate cdk activity. The one or more agents that modulate cdk activity can be small molecules or biological molecules. In one aspect, the agent is a small molecule that inhibits cyclin-dependent kinase 2 (cdk2)/cyclin E.  
         [0012]     The invention also provides a method for testing or predicting whether a mammal will respond therapeutically to a method of treating cancer comprising administering an agent that modulates cdk activity, wherein the method comprises: (a) measuring in the mammal the level of at least one biomarker selected from the biomarkers of Table 1; (b) exposing the mammal to the agent that modulates cdk activity; (c) following the exposing of step (b), measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates that the mammal will respond therapeutically to said method of treating cancer.  
         [0013]     The invention also provides a method for determining whether a mammal is responding to an agent that modulates cdk activity, comprising: (a) exposing the mammal to the agent; and (b) following the exposing of step (a), measuring in the mammal the level of at least one biomarker selected from the biomarkers of Table 1, wherein a difference in the level of the at least one biomarker measured in step (b), compared to the level of the at least one biomarker in a mammal that has not been exposed to said agent, indicates that the mammal is responding to the agent that modulates cdk activity.  
         [0014]     As used herein, responding includes, for example, a biological response (e.g., a cellular response) or a clinical response (e.g., improved symptoms, a therapeutic effect, or an adverse event) in the mammal.  
         [0015]     The invention also provides a method for determining whether a mammal is responding to an agent that modulates cdk activity, comprising: (a) obtaining a biological sample from the mammal; (b) measuring in said biological sample the level of at least one biomarker selected from the biomarkers of Table 1; (c) correlating said level of at least one biomarker with a baseline level; and (d) determining whether the mammal is responding to an agent that modulates cdk activity based on said correlation.  
         [0016]     As used herein, the baseline level used for the correlation can be determined by one of skill in the art. In one aspect, the baseline level is the level of the at least one biomarker selected from the biomarkers of Table 1 in a mammal that has not been exposed to the agent. In another aspect, the baseline level is the level of the at least one biomarker selected from the biomarkers of Table 1 in the mammal that will be treated with a cdk modulating agent but has not yet been exposed to the agent. In yet another aspect, the baseline level is the level of the at least one biomarker selected from the biomarkers of Table 1 in the mammal that has been treated with a cdk modulating agent, and wherein the baseline level is selected at a point during the treatment with the cdk modulating agent. The point can be, for example, an established time period or measurement of a criteria (e.g., a biological or clinical response) set prior to initiation of the treatment.  
         [0017]     A difference between the level of at least one biomarker from the mammal and the baseline level that is statistically significant can be used in the methods of the invention. A statistically significant difference between the level of at least one biomarker from the mammal and the baseline level is readily determined by one of skill in the art and can be, for example, at least a two-fold difference, at least a three-fold difference, or at least a four-fold difference in the level of the at least one biomarker.  
         [0018]     The invention also provides a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an agent that modulates cdk activity, wherein the method comprises: (a) measuring in the mammal the level of at least one biomarker selected from the biomarkers of Table 1; (b) exposing a biological sample from the mammal to the agent; (c) following the exposing in step (b), measuring in said biological sample the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates that the mammal will respond therapeutically to the said method of treating cancer.  
         [0019]     As used herein, respond therapeutically refers to the alleviation or abrogation of the cancer. This means that the life expectancy of an individual affected with the cancer will be increased or that one or more of the symptoms of the cancer will be reduced or ameliorated. The term encompasses a reduction in cancerous cell growth or tumor volume. Whether a mammal responds therapeutically can be measured by many methods well known in the art, such as PET imaging.  
         [0020]     The invention also provides a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an agent that modulates cdk activity, wherein the method comprises: (a) exposing a biological sample from the mammal to the agent that modulates cdk activity; (b) following the exposing of step (a), measuring in said biological sample the level of at least one biomarker selected from the biomarkers of Table 1, wherein a difference in the level of the at least one biomarker measured in step (b), compared to the level of the at least one biomarker in a mammal that has not been exposed to said agent that modulates cdk activity, indicates that the mammal will respond therapeutically to said method of treating cancer.  
         [0021]     The invention also provides a method for determining whether an agent modulates cdk activity in a mammal, comprising: (a) exposing the mammal to the agent; and (b) following the exposing of step (a), measuring in the mammal the level of at least one biomarker selected from the biomarkers of Table 1, wherein a difference in the level of said biomarker measured in step (b), compared to the level of the biomarker in a mammal that has not been exposed to said agent, indicates that the agent modulates cdk activity in the mammal.  
         [0022]     The invention also provides a method for determining whether a mammal has been exposed to an agent that modulates cdk activity, comprising (a) exposing a biological sample from the mammal to the agent; and (b) following the exposing of step (a), measuring in the biological sample the level of at least one biomarker selected from the biomarkers of Table 1, wherein a difference in the level of said biomarker measured in step (b), compared to the level of the biomarker in a mammal that has not been exposed to said agent, indicates that the mammal has been exposed to an agent that modulates cdk activity.  
         [0023]     The mammal can be, for example, a human, rat, mouse, dog, rabbit, pig sheep, cow, horse, cat, primate, or monkey.  
         [0024]     The method of the invention can be an in vivo or an in vitro method. In one aspect, the step of measuring in the mammal the level of at least one biomarker is in vitro and comprises taking a biological sample from the mammal and then measuring the level of the at least one biomarker in the biological sample. The biological sample can comprise, for example, at least one of whole fresh blood, peripheral blood mononuclear cells, frozen whole blood, fresh plasma, frozen plasma, urine, saliva, skin, hair follicle, bone marrow, or tumor tissue.  
         [0025]     In one aspect of the invention, the method of the invention comprises use of the biomarker W28729 (SEQ ID NO:1246).  
         [0026]     The level of the at least one biomarker can be, for example, the level of protein and/or mRNA transcript of the at least one biomarker.  
         [0027]     The invention also provides an isolated biomarker selected from the biomarkers of Table 1. The biomarkers of the invention comprise sequences selected from the nucleotide and amino acid sequences provided in Table 1 and the Sequence Listing, including fragments and variants thereof.  
         [0028]     The invention also provides one or more biomarkers that can serve as targets for the development of therapies for disease treatment. Such targets may be particularly applicable for treatment of cancers or tumors.  
         [0029]     The invention also provides a biomarker set comprising two or more biomarkers selected from the biomarkers of Table 1.  
         [0030]     The invention also provides kits for determining or predicting whether a patient would be susceptible or resistant to a treatment that comprises one or more agents that modulate cdk activity. In one aspect, the patient has a cancer.  
         [0031]     In one aspect, the kit comprises a suitable container that comprises one or more specialized microarrays of the invention, one or more agents that modulate cdk activity for use in testing cells from patient tissue specimens or patient samples, and instructions for use. The kit may further comprise reagents or materials for monitoring the expression of a biomarker set at the level of mRNA or protein.  
         [0032]     The invention also provides a kit that comprises two or more biomarkers selected from the biomarkers of Table 1.  
         [0033]     The invention also provides a kit that comprises at least one of an antibody and a nucleic acid for detecting the presence of at least one of the biomarkers selected from the biomarkers of Table 1. In one aspect, the kit further comprises instructions for determining whether or not a mammal will respond therapeutically to a method of treating cancer comprising administering an agent that modulates cdk activity. In another aspect, the instructions comprise the steps of (a) measuring in the mammal the level of at least one biomarker selected from the biomarkers of Table 1, (b) exposing the mammal to the agent, (c) following the exposing of step (b), measuring in the mammal the level of the at least one biomarker, wherein a difference in the level of the at least one biomarker measured in step (c) compared to the level of the at least one biomarker measured in step (a) indicates that the mammal will respond therapeutically to said method of treating cancer.  
         [0034]     The invention also provides screening assays for determining if a patient will be susceptible or resistant to treatment with one or more agents that modulate cdk activity.  
         [0035]     The invention also provides a method of monitoring the treatment of a patient having a disease, wherein said disease is treated by a method comprising administering one or more agents that modulate cdk activity.  
         [0036]     The invention also provides individualized genetic profiles which are necessary to treat diseases and disorders based on patient response at a molecular level.  
         [0037]     The invention also provides specialized microarrays, e.g., oligonucleotide microarrays or cDNA microarrays, comprising one or more biomarkers having expression profiles that correlate with either sensitivity or resistance to one or more agents that modulate cdk activity.  
         [0038]     The invention also provides antibodies, including polyclonal and monoclonal, directed against one or more of the biomarker polypeptides. Such antibodies can be used in a variety of ways, for example, to purify, detect, and target the biomarker polypeptides of the invention, including both in vitro and in vivo diagnostic, detection, screening, and/or therapeutic methods.  
         [0039]     The invention also provides a cell culture model to identity biomarkers whose expression levels correlate with cdk modulation.  
         [0040]     The invention will be better understood upon a reading of the detailed description of the invention when considered in connection with the accompanying figures. 
     
    
     BRIEF DESCRIPTION OF THE FIGURES  
       [0041]      FIG. 1  illustrates a cdk biomarker identification strategy.  
         [0042]      FIGS. 2A and 2B  illustrate the reduction of cdk2 protein levels by cdk2 antisense oligonucleotides.  
         [0043]      FIGS. 3A, 3B , and  3 C illustrate the expression changes of the biomarker W28729 (SEQ ID NO:1246) in A2780s, PBMC, and xenograft A2780s tumors following treatment with a cdk inhibitor.  
         [0044]      FIGS. 4A and 4B  illustrate the regulation of W28729 expression in A2780 xenograft ( FIG. 4A ) and the mouse ortholog of W28729 in mouse PBMC ( FIG. 4B ).  
         [0045]      FIGS. 5A and 5B  illustrate W28729 gene expression in patients treated with N-5-[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl-4-piperidinecarboxamide, 0.5-L-tartaric acid salt.  
         [0046]      FIGS. 6A and 6B  illustrate W28729 induction and its relation to baseline expression.  
         [0047]      FIGS. 7A and 7B  illustrate W28729 induction as a function of dose ( FIG. 7A ) and AUC ( FIG. 7B ).  
         [0048]      FIG. 8  illustrates the prediction of W28729 changes by baseline expression of W28729 and the cdk2 inhibitor exposure.  
         [0049]      FIG. 9  illustrates disease outcome, time to tumor progression (TTP) and W28729 changes. 
     
    
     DETAILED DESCRIPTION OF THE INVENTION  
       [0050]     As used herein, the term “agent that modulates cdk activity,” also referred to herein as “cdk modulating agent,” is intended to mean a substance that is a biological molecule or a small molecule, and formulations thereof, that is directly or indirectly involved in cdk activity and/or one or more pathways in which cdk is involved. The cdk modulating agent can be a cdk antagonist or inhibitor. The cdk modulating agent can also be a cdk agonist or activator.  
         [0051]     In one aspect, the cdk modulating agent is directly or indirectly involved in cdk2 activity and/or one or more pathways in which cdk2 is involved. In another aspect, the cdk modulating agent is directly or indirectly involved in cdk1 activity and/or one or more pathways in which cdk1 is involved. In yet another aspect, the cdk modulating agent is directly or indirectly involved in cdk4 activity and/or one or more pathways in which cdk4 is involved.  
         [0052]     Biological molecules include all lipids and polymers of monosaccharides, amino acids, and nucleotides having a molecular weight greater than 450. Thus, biological molecules include, for example, oligosaccharides and polysaccharides; oligopeptides, polypeptides, peptides, and proteins; and oligonucleotides and polynucleotides. Oligonucleotides and polynucleotides include, for example, DNA and RNA. Biological molecules further include derivatives of any of the molecules described above. For example, derivatives of biological molecules include lipid and glycosylation derivatives of oligopeptides, polypeptides, peptides, and proteins.  
         [0053]     In addition to the biological molecules discussed above, the cdk modulating agents may also be small molecules. Any molecule that is not a biological molecule is considered herein to be a small molecule. Some examples of small molecules include organic compounds, organometallic compounds, salts of organic and organometallic compounds, saccharides, amino acids, and nucleotides. Small molecules further include molecules that would otherwise be considered biological molecules, except their molecular weight is not greater than 450. Thus, small molecules may be lipids, oligosaccharides, oligopeptides, and oligonucleotides and their derivatives, having a molecular weight of 450 or less.  
         [0054]     It is emphasized that small molecules can have any molecular weight. They are merely called small molecules because they typically have molecular weights less than 450. Small molecules include compounds that are found in nature as well as synthetic compounds. In one embodiment, the cdk modulating agent is a small molecule that inhibits cdk or a pathway in which cdk is involved.  
         [0055]     Numerous small molecules have been described as being useful to inhibit cdk including, for example, flavopiridol (Aventis Pharmaceuticals Inc., Bridgewater, N.J., U.S.A.) and CYC202 (Cyclacel Limited, Dundee, United Kingdom). Cdk inhibitors also include, for example, the small molecules disclosed in U.S. Pat. Nos. 6,040,321, 6,214,852, 6,262,096, 6,515,004, and 6,521,759.  
         [0056]     In one aspect, the cdk modulating agent is a small molecule cdk inhibitor. In another aspect, the cdk modulating agent is a small molecule cdk2 inhibitor. In another aspect, the cdk modulating agent is a small molecule cdk1 inhibitor. In yet another aspect, the cdk modulating agent is a small molecule cdk4 inhibitor. In a further aspect, the cdk modulating agent is N-5-[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl-4-piperidinecarboxamide, 0.5-L-tartaric acid salt.  
         [0057]     The invention provides methods to monitor the response of patients to treatment with a cdk modulating agent. These methods are useful: (i) to follow the response of a patient over a course of treatment with a cdk modulating agent; (ii) to determine whether the specific cdk modulating agent selected for treatment is appropriate to the patient; (iii) to determine whether the dose of the cdk modulating agent being administered is appropriate to the patient; (iv) to determine whether the type and/or amount of cdk modulating agent being administered needs to be changed over the course of the treatment period; (v) to determine when treatment is complete; and (vi) to determine whether treatment that has been terminated needs to be restarted. These methods are also useful to identify whether a patient will benefit from treatment with a cdk modulating agent.  
         [0058]     In one aspect, the invention provides a method of determining whether a patient receiving a treatment that comprises a cdk modulating agent has received sufficient treatment to inhibit cdk in the patient&#39;s tumors. In accordance with the invention, tumor or surrogate biopsies are obtained from a patient before and after treatment with a cdk modulating agent. The surrogate biopsies can be, for example, skin or peripheral blood. The cells are then assayed to determine the changes in the expression pattern of one or more biomarkers of the invention upon treatment with the cdk modulating agent, to determine whether cdk inhibition has been achieved by the treatment. Success or failure of the treatment can be determined based on the expression pattern of the test cells from the test tissue, e.g., tumor or cancer biopsy, as being relatively the same as or different from the expression pattern of one or more biomarkers. If the test cells show an expression profile which corresponds to that of the biomarker or biomarker set, it is predicted that the individual&#39;s cancer or tumor has been exposed to a concentration of the modulating agent that is sufficient to, in one aspect, inhibit cdk. By contrast, if the test cells show a gene expression pattern that does not correspond to the biomarker or biomarker set, it is predicted that the modulating agent exposure has not been sufficient to, in one aspect, inhibit cdk.  
         [0059]     In another aspect, the invention provides a method of monitoring the treatment of a patient having a disease treatable by a cdk modulating agent by comparing the expression profile of cells from a patient tissue sample, e.g., a tumor or cancer biopsy, following treatment to a biomarker or biomarker set. The isolated cells from the patient are assayed to determine their expression pattern to determine if a change of the expression profile has occurred so as to warrant a different treatment, such as treatment with a different cdk modulating agent, or to discontinue current treatment. The resulting expression profile of the cells following treatment with a cdk modulating agent is compared with the expression pattern of the biomarker or biomarker set.  
         [0060]     Such a monitoring process can indicate success or failure of a patient&#39;s treatment with a cdk modulating agent based on the expression pattern of the cells isolated from the patient&#39;s sample as being relatively the same as or different from the expression pattern of the biomarker or biomarker set Thus, if, after treatment with a cdk modulating agent, the test cells show a change in their expression profile from the biomarker or biomarker set, it can serve as an indicator that the current treatment should be modified, changed, or even discontinued. Such monitoring processes can be repeated as necessary or desired. The monitoring of a patient&#39;s response to a given treatment can also involve testing the patient&#39;s cells in the assay as described only after treatment with a cdk modulating agent, rather than before and after treatment with a cdk modulating agent.  
         [0061]     The invention is based on the identification of specific pharmacodynamic biomarkers of cdk modulation. In accordance with the invention, oligonucleotide microarrays were used to measure the expression levels of a large number of genes in a panel of treated cell lines for which sensitivity to a cdk modulating agent was determined. The determination of the gene expression profiles in the treated cells allowed the identification of biomarkers whose expression levels highly correlate with the modulation of cdk or a pathway in which cdk is involved. The biomarkers are thus useful for inferring the level of cdk modulation in a patient.  
         [0062]     The biomarkers of the invention include polynucleotides, including full-length genes, open reading frames (ORFs), and partial sequences such as expressed sequence tags (ESTs) and structural RNA. In one aspect, the invention is directed to an isolated polynucleotide comprising a nucleotide sequence selected from the nucleotide sequences of Table 1 such as, for example, an isolated polynucleotide comprising the nucleotide sequence of SEQ ID NO:1264. The biomarkers further include polypeptides comprising the amino acid sequences encoded by these polynucleotides. The biomarkers of the invention include those provided below in Table 1. In one aspect, these polynucleotides and polypeptides are in isolated form.  
                                                     TABLE 1                       SEQ ID   Sequence   Genbank Accession               NO:   type   No.   Symbol   Description                                1   DNA   NM_005340   HINT1   histidine triad nucleotide                       binding protein 1       2   Protein   NP_005331   HINT1   histidine triad nucleotide                       binding protein 1       3   DNA   NM_003137   SRPK1   SFRS protein kinase 1       4   Protein   NP_003128   SRPK1   SFRS protein kinase 1       5   DNA   NM_001951   E2F5   E2F transcription factor 5,                       p130-binding       6   Protein   NP_001942   E2F5   E2F transcription factor 5,                       p130-binding       7   DNA   U33838       NF-kappa-B p65delta3, mRNA                       sequence       8   Protein   U33838 (Translation)       NF-kappa-B p65delta3, mRNA                       sequence       9   DNA   NM_005195   CEBPD   CCAAT/enhancer binding                       protein (C/EBP), delta       10   Protein   NP_005186   CEBPD   CCAAT/enhancer binding                       protein (C/EBP), delta       11   DNA   NM_002916   RFC4   replication factor C (activator                       1) 4, 37 kDa       12   Protein   NP_002907   RFC4   replication factor C (activator                       1) 4, 37 kDa       13   DNA   NM_002050   MGC2306   hypothetical protein MGC2306       14   Protein   NP_002041   MGC2306   hypothetical protein MGC2306       15   DNA   NM_032638   MGC2306   hypothetical protein MGC2306       16   Protein   NP_116027   MGC2306   hypothetical protein MGC2306       17   DNA   NM_001709   BDNF   brain-derived neurotrophic                       factor       18   Protein   NP_001700   BDNF   brain-derived neurotrophic                       factor       19   DNA   NM_170731   BDNF   brain-derived neurotrophic                       factor       20   Protein   NP_733927   BDNF   brain-derived neurotrophic                       factor       21   DNA   NM_170732   BDNF   brain-derived neurotrophic                       factor       22   DNA   NM_170733   BDNF   brain-derived neurotrophic                       factor       23   DNA   NM_006749   SLC20A2   solute carrier family 20                       (phosphate transporter),                       member 2       24   Protein   NP_006740   SLC20A2   solute carrier family 20                       (phosphate transporter),                       member 2       25   DNA   NM_005415   SLC20A1   solute carrier family 20                       (phosphate transporter),                       member 1       26   Protein   NP_005406   SLC20A1   solute carrier family 20                       (phosphate transporter),                       member 1       27   DNA   HG3510-HT3704       V-Erba Related Ear-3 Protein       28   DNA   HG1471-HT3923       Transcription Factor Oct-1a/1b,                       Alt. Splice 2, Oct-1b       29   DNA   NM_002816   PSMD12   proteasome (prosome,                       macropain) 26S subunit, non-                       ATPase, 12       30   Protein   NP_002807   PSMD12   proteasome (prosome,                       macropain) 26S subunit, non-                       ATPase, 12       31   DNA   NM_003138   SRPK2   SFRS protein kinase 2       32   Protein   NP_003129   SRPK2   SFRS protein kinase 2       33   DNA   NM_005930   MGEA6   meningioma expressed antigen                       6 (coiled-coil proline-rich)       34   Protein   NP_005921   MGEA6   meningioma expressed antigen                       6 (coiled-coil proline-rich)       35   DNA   NM_003337   UBE2B   ubiquitin-conjugating enzyme                       E2B (RAD6 homolog)       36   Protein   NP_003328   UBE2B   ubiquitin-conjugating enzyme                       E2B (RAD6 homolog)       37   DNA   NM_003406   YWHAZ   tyrosine 3-                       monooxygenase/tryptophan 5-                       monooxygenase activation                       protein, zeta polypeptide       38   Protein   NP_003397   YWHAZ   tyrosine 3-                       monooxygenase/tryptophan 5-                       monooxygenase activation                       protein, zeta polypeptide       39   DNA   NM_145690   YWHAZ   tyrosine 3-                       monooxygenase/tryptophan 5-                       monooxygenase activation                       protein, zeta polypeptide       40   DNA   NM_006494   ERF   Ets2 repressor factor       41   Protein   NP_006485   ERF   Ets2 repressor factor       42   DNA   NM_006904   PRKDC   protein kinase, DNA-activated,                       catalytic polypeptide       43   Protein   NP_008835   PRKDC   protein kinase, DNA-activated,                       catalytic polypeptide       44   DNA   NM_021975   RELA   v-rel reticuloendotheliosis viral                       oncogene homolog A, nuclear                       factor of kappa light                       polypeptide gene enhancer in                       B-cells 3, p65 (avian)       45   Protein   NP_068810   RELA   v-rel reticuloendotheliosis viral                       oncogene homolog A, nuclear                       factor of kappa light                       polypeptide gene enhancer in                       B-cells 3, p65 (avian)       46   DNA   NM_004359   CDC34   cell division cycle 34       47   Protein   NP_004350   CDC34   cell division cycle 34       48   DNA   NM_000380   XPA   xeroderma pigmentosum,                       complementation group A       49   Protein   NP_000371   XPA   xeroderma pigmentosum,                       complementation group A       50   DNA   NM_004152   OAZ1   ornithine decarboxylase                       antizyme 1       51   Protein   NP_004143   OAZ1   ornithine decarboxylase                       antizyme 1       52   DNA   NM_003250   THRA   thyroid hormone receptor,                       alpha (erythroblastic leukemia                       viral (v-erb-a) oncogene                       homolog, avian)       53   Protein   NP_003241   THRA   thyroid hormone receptor,                       alpha (erythroblastic leukemia                       viral (v-erb-a) oncogene                       homolog, avian)       54   DNA   NM_005900   MADH1   MAD, mothers against                       decapentaplegic homolog 1                       ( Drosophila )       55   Protein   NP_005891   MADH1   MAD, mothers against                       decapentaplegic homolog 1                       ( Drosophila )       56   DNA   NM_004444   EPHB4   EphB4       57   Protein   NP_004435   EPHB4   EphB4       58   DNA   NM_021009   UBC   ubiquitin C       59   Protein   NP_066289   UBC   ubiquitin C       60   DNA   NM_003200   TCF3   transcription factor 3 (E2A                       immunoglobulin enhancer                       binding factors E12/E47)       61   Protein   NP_003191   TCF3   transcription factor 3 (E2A                       immunoglobulin enhancer                       binding factors E12/E47)       62   DNA   NM_002717   PPP2R2A   protein phosphatase 2 (formerly                       2A), regulatory subunit B (PR                       52), alpha isoform       63   Protein   NP_002708   PPP2R2A   protein phosphatase 2 (formerly                       2A), regulatory subunit B (PR                       52), alpha isoform       64   DNA   NM_000358   TGFBI   transforming growth factor,                       beta-induced, 68 kDa       65   Protein   NP_000349   TGFBI   transforming growth factor,                       beta-induced, 68 kDa       66   DNA   NM_001664   ARHA   ras homolog gene family,                       member A       67   Protein   NP_001655   ARHA   ras homolog gene family,                       member A       68   DNA   NM_002419   MAP3K11   mitogen-activated protein                       kinase kinase kinase 11       69   Protein   NP_002410   MAP3K11   mitogen-activated protein                       kinase kinase kinase 11       70   DNA   NM_004593   SFRS10   splicing factor, arginine/serine-                       rich 10 (transformer 2 homolog,                         Drosophila )       71   Protein   NP_004584   SFRS10   splicing factor, arginine/serine-                       rich 10 (transformer 2 homolog,                         Drosophila )       72   DNA   NM_003131   SRF   serum response factor (c-fos                       serum response element-                       binding transcription factor)       73   Protein   NP_003122   SRF   serum response factor (c-fos                       serum response element-                       binding transcription factor)       74   DNA   NM_000376   VDR   vitamin D (1,25-                       dihydroxyvitamin D3) receptor       75   Protein   NP_000367   VDR   vitamin D (1,25-                       dihydroxyvitamin D3) receptor       76   DNA   D26561       D26561 /FEATURE = cds#2                       /DEFINITION = D26561  Homo                           sapiens  cellular DNA                       containing a segment of Human                       papilloma virus type 5b, partial                       and complete cds       77   Protein   D26561 (Translation)       D26561 /FEATURE = cds#2                       /DEFINITION = D26561  Homo                           sapiens  cellular DNA                       containing a segment of Human                       papilloma virus type 5b, partial                       and complete cds       78   DNA   NM_002651   PIK4CB   phosphatidylinositol 4-kinase,                       catalytic, beta polypeptide       79   Protein   NP_002642   PIK4CB   phosphatidylinositol 4-kinase,                       catalytic, beta polypeptide       80   DNA   NM_002830   PTPN4   protein tyrosine phosphatase,                       non-receptor type 4                       (megakaryocyte)       81   Protein   NP_002821   PTPN4   protein tyrosine phosphatase,                       non-receptor type 4                       (megakaryocyte)       82   DNA   NM_020529   NFKBIA   nuclear factor of kappa light                       polypeptide gene enhancer in                       B-cells inhibitor, alpha       83   Protein   NP_065390   NFKBIA   nuclear factor of kappa light                       polypeptide gene enhancer in                       B-cells inhibitor, alpha       84   DNA   NM_006292   TSG101   tumor susceptibility gene 101       85   Protein   NP_006283   TSG101   tumor susceptibility gene 101       86   DNA   NM_005375   MYB   v-myb myeloblastosis viral                       oncogene homolog (avian)       87   Protein   NP_005366   MYB   v-myb myeloblastosis viral                       oncogene homolog (avian)       88   DNA   NM_002836   PTPRA   protein tyrosine phosphatase,                       receptor type, A       89   Protein   NP_002827   PTPRA   protein tyrosine phosphatase,                       receptor type, A       90   DNA   NM_080840   PTPRA   protein tyrosine phosphatase,                       receptor type, A       91   Protein   NP_543030   PTPRA   protein tyrosine phosphatase,                       receptor type, A       92   DNA   NM_080841   PTPRA   protein tyrosine phosphatase,                       receptor type, A       93   DNA   NM_002027   FNTA   farnesyltransferase, CAAX                       box, alpha       94   Protein   NP_002018   FNTA   farnesyltransferase, CAAX                       box, alpha       95   DNA   X95152       X95152 /FEATURE = mRNA                       /DEFINITION = HSBRCA22                         H. sapiens  brca2 gene exon 2                       (and joined coding region)       96   Protein   X95152 (Translation)       X95152 /FEATURE = mRNA                       /DEFINITION = HSBRCA22                         H. sapiens  brca2 gene exon 2                       (and joined coding region)       97   DNA   NM_016848   SHC3   neuronal Shc       98   Protein   NP_058544   SHC3   neuronal Shc       99   DNA   HG4074-HT4344       Rad2       100   DNA   NM_006119   FGF8   fibroblast growth factor 8                       (androgen-induced)       101   Protein   NP_006110   FGF8   fibroblast growth factor 8                       (androgen-induced)       102   DNA   NM_033163   FGF8   fibroblast growth factor 8                       (androgen-induced)       103   Protein   NP_149353   FGF8   fibroblast growth factor 8                       (androgen-induced)       104   DNA   NM_033164   FGF8   fibroblast growth factor 8                       (androgen-induced)       105   Protein   NP_149354   FGF8   fibroblast growth factor 8                       (androgen-induced)       106   DNA   NM_033165   FGF8   fibroblast growth factor 8                       (androgen-induced)       107   Protein   NP_149355   FGF8   fibroblast growth factor 8                       (androgen-induced)       108   DNA   NM_000057   BLM   Bloom syndrome       109   Protein   NP_000048   BLM   Bloom syndrome       110   DNA   NM_005778   RBM5   RNA binding motif protein 5       111   Protein   NP_005769   RBM5   RNA binding motif protein 5       112   DNA   NM_001067   TOP2A   topoisomerase (DNA) II alpha                       170 kDa       113   Protein   NP_001058   TOP2A   topoisomerase (DNA) II alpha                       170 kDa       114   DNA   NM_003473   STAM   signal transducing adaptor                       molecule (SH3 domain and                       ITAM motif) 1       115   Protein   NP_003464   STAM   signal transducing adaptor                       molecule (SH3 domain and                       ITAM motif) 1       116   DNA   NM_005354   JUND   jun D proto-oncogene       117   Protein   NP_005345   JUND   jun D proto-oncogene       118   DNA   HG3187-HT3366       Tyrosine Phosphatase 1, Non-                       Receptor, Alt. Splice 3       119   DNA   NM_006875   PIM2   pim-2 oncogene       120   Protein   NP_006866   PIM2   pim-2 oncogene       121   DNA   NM_004327   BCR   breakpoint cluster region       122   Protein   NP_004318   BCR   breakpoint cluster region       123   DNA   NM_021574   BCR   breakpoint cluster region       124   Protein   NP_067585   BCR   breakpoint cluster region       125   DNA   NM_001969   EIF5   eukaryotic translation initiation                       factor 5       126   Protein   NP_001960   EIF5   eukaryotic translation initiation                       factor 5       127   DNA   NM_002890   RASA1   RAS p21 protein activator                       (GTPase activating protein) 1       128   Protein   NP_002881   RASA1   RAS p21 protein activator                       (GTPase activating protein) 1       129   DNA   NM_022650   RASA1   RAS p21 protein activator                       (GTPase activating protein) 1       130   Protein   NP_072179   RASA1   RAS p21 protein activator                       (GTPase activating protein) 1       131   DNA   NM_001404   EEF1G   eukaryotic translation                       elongation factor 1 gamma       132   Protein   NP_001395   EEF1G   eukaryotic translation                       elongation factor 1 gamma       133   DNA   NM_006156   NEDD8   neural precursor cell expressed,                       developmentally down-                       regulated 8       134   Protein   NP_006147   NEDD8   neural precursor cell expressed,                       developmentally down-                       regulated 8       135   DNA   NM_003010   MAP2K4   mitogen-activated protein                       kinase kinase 4       136   Protein   NP_003001   MAP2K4   mitogen-activated protein                       kinase kinase 4       137   DNA   HG884-HT884       Oncogene E6-Ap,                       Papillomavirus       138   DNA   NM_001789   CDC25A   cell division cycle 25A       139   Protein   NP_001780   CDC25A   cell division cycle 25A       140   DNA   NM_001350   DAXX   death-associated protein 6       141   Protein   NP_001341   DAXX   death-associated protein 6       142   DNA   NM_002719   PPP2R5C   protein phosphatase 2,                       regulatory subunit B (B56),                       gamma isoform       143   Protein   NP_002710   PPP2R5C   protein phosphatase 2,                       regulatory subunit B (B56),                       gamma isoform       144   DNA   NM_002689   POLA2   polymerase (DNA-directed),                       alpha (70 kD)       145   Protein   NP_002680   POLA2   polymerase (DNA-directed),                       alpha (70 kD)       146   DNA   NM_005056   RBBP2   retinoblastoma binding protein 2       147   Protein   NP_005047   RBBP2   retinoblastoma binding protein 2       148   DNA   NM_001800   CDKN2D   cyclin-dependent kinase                       inhibitor 2D (p19, inhibits                       CDK4)       149   Protein   NP_001791   CDKN2D   cyclin-dependent kinase                       inhibitor 2D (p19, inhibits                       CDK4)       150   DNA   NM_079421   CDKN2D   cyclin-dependent kinase                       inhibitor 2D (p19, inhibits                       CDK4)       151   DNA   NM_000465   BARD1   BRCA1 associated RING                       domain 1       152   Protein   NP_000456   BARD1   BRCA1 associated RING                       domain 1       153   DNA   NM_001786   CDC2   cell division cycle 2, G1 to S                       and G2 to M       154   Protein   NP_001777   CDC2   cell division cycle 2, G1 to S                       and G2 to M       155   DNA   NM_033379   CDC2   cell division cycle 2, G1 to S                       and G2 to M       156   Protein   NP_203698   CDC2   cell division cycle 2, G1 to S                       and G2 to M       157   DNA   NM_003503   CDC7L1   CDC7 cell division cycle 7-like                       1 ( S. cerevisiae )       158   Protein   NP_003494   CDC7L1   CDC7 cell division cycle 7-like                       1 ( S. cerevisiae )       159   DNA   NM_006254   PRKCD   protein kinase C, delta       160   Protein   NP_006245   PRKCD   protein kinase C, delta       161   DNA   NM_003242   TGFBR2   transforming growth factor,                       beta receptor II (70/80 kDa)       162   Protein   NP_003233   TGFBR2   transforming growth factor,                       beta receptor II (70/80 kDa)       163   DNA   HG1996-HT2044       Guanine Nucleotide-Binding                       Protein Rap2, Ras-Oncogene                       Related       164   DNA   NM_005904   MADH7   MAD, mothers against                       decapentaplegic homolog 7                       ( Drosophila )       165   Protein   NP_005895   MADH7   MAD, mothers against                       decapentaplegic homolog 7                       ( Drosophila )       166   DNA   NM_005426   TP53BP2   tumor protein p53 binding                       protein, 2       167   Protein   NP_005417   TP53BP2   tumor protein p53 binding                       protein, 2       168   DNA   NM_004322   BAD   BCL2-antagonist of cell death       169   Protein   NP_004313   BAD   BCL2-antagonist of cell death       170   DNA   NM_032989   BAD   BCL2-antagonist of cell death       171   DNA   NM_004579   MAP4K2   mitogen-activated protein                       kinase kinase kinase kinase 2       172   Protein   NP_004570   MAP4K2   mitogen-activated protein                       kinase kinase kinase kinase 2       173   DNA   HG1103-HT1103       Guanine Nucleotide-Binding                       Protein Ral, Ras-Oncogene                       Related       174   DNA   NM_006270   RRAS   related RAS viral (r-ras)                       oncogene homolog       175   Protein   NP_006261   RRAS   related RAS viral (r-ras)                       oncogene homolog       176   DNA   NM_002592   PCNA   proliferating cell nuclear                       antigen       177   Protein   NP_002583   PCNA   proliferating cell nuclear                       antigen       178   DNA   NM_000038   APC   adenomatosis polyposis coli       179   Protein   NP_000029   APC   adenomatosis polyposis coli       180   DNA   NM_002880   RAF1   v-raf-1 murine leukemia viral                       oncogene homolog 1       181   Protein   NP_002871   RAF1   v-raf-1 murine leukemia viral                       oncogene homolog 1       182   DNA   NM_005642   TAF7   TAF7 RNA polymerase II,                       TATA box binding protein                       (TBP)-associated factor, 55 kDa       183   Protein   NP_005633   TAF7   TAF7 RNA polymerase II,                       TATA box binding protein                       (TBP)-associated factor, 55 kDa       184   DNA   NM_001761   CCNF   cyclin F       185   Protein   NP_001752   CCNF   cyclin F       186   DNA   NM_004985   KRAS2   v-Ki-ras2 Kirsten rat sarcoma 2                       viral oncogene homolog       187   Protein   NP_004976   KRAS2   v-Ki-ras2 Kirsten rat sarcoma 2                       viral oncogene homolog       188   DNA   NM_033360   KRAS2   v-Ki-ras2 Kirsten rat sarcoma 2                       viral oncogene homolog       189   Protein   NP_203524   KRAS2   v-Ki-ras2 Kirsten rat sarcoma 2                       viral oncogene homolog       190   DNA   NM_000075   CDK4   cyclin-dependent kinase 4       191   Protein   NP_000066   CDK4   cyclin-dependent kinase 4       192   DNA   NM_032913   CDK4   cyclin-dependent kinase 4       193   Protein   NP_116302   CDK4   cyclin-dependent kinase 4       194   DNA   NM_052984   CDK4   cyclin-dependent kinase 4       195   Protein   NP_443710   CDK4   cyclin-dependent kinase 4       196   DNA   NM_001237   CCNA2   cyclin A2       197   Protein   NP_001228   CCNA2   cyclin A2       198   DNA   NM_031966   CCNB1   cyclin B1       199   Protein   NP_114172   CCNB1   cyclin B1       200   DNA   NM_005903   MADH5   MAD, mothers against                       decapentaplegic homolog 5                       ( Drosophila )       201   Protein   NP_005894   MADH5   MAD, mothers against                       decapentaplegic homolog 5                       ( Drosophila )       202   DNA   NM_001799   CDK7   cyclin-dependent kinase 7                       (MO15 homolog,  Xenopus                           laevis , cdk-activating kinase)       203   Protein   NP_001790   CDK7   cyclin-dependent kinase 7                       (MO15 homolog,  Xenopus                           laevis , cdk-activating kinase)       204   DNA   NM_002512   NME2   non-metastatic cells 2, protein                       (NM23B) expressed in       205   Protein   NP_002503   NME2   non-metastatic cells 2, protein                       (NM23B) expressed in       206   DNA   NM_000269   NME1   non-metastatic cells 1, protein                       (NM23A) expressed in       207   Protein   NP_000260   NME1   non-metastatic cells 1, protein                       (NM23A) expressed in       208   DNA   NM_006256   PRKCL2   protein kinase C-like 2       209   Protein   NP_006247   PRKCL2   protein kinase C-like 2       210   DNA   NM_000179   MSH6   mutS homolog 6 ( E. coli )       211   Protein   NP_000170   MSH6   mutS homolog 6 ( E. coli )       212   DNA   NM_004048   B2M   beta-2-microglobulin       213   Protein   NP_004039   B2M   beta-2-microglobulin       214   DNA   NM_006013   RPL10   ribosomal protein L10       215   Protein   NP_006004   RPL10   ribosomal protein L10       216   DNA   NM_004506   HSF2   heat shock transcription factor 2       217   Protein   NP_004497   HSF2   heat shock transcription factor 2       218   DNA   NM_001238   CCNE1   cyclin E1       219   Protein   NP_001229   CCNE1   cyclin E1       220   DNA   NM_057182   CCNE1   cyclin E1       221   Protein   NP_476530   CCNE1   cyclin E1       222   DNA   NM_001641   APEX1   APEX nuclease                       (multifunctional DNA repair                       enzyme) 1       223   Protein   NP_001632   APEX1   APEX nuclease                       (multifunctional DNA repair                       enzyme) 1       224   DNA   NM_080648   APEX1   APEX nuclease                       (multifunctional DNA repair                       enzyme) 1       225   DNA   NM_080649   APEX1   APEX nuclease                       (multifunctional DNA repair                       enzyme) 1       226   DNA   NM_001982   ERBB3   v-erb-b2 erythroblastic                       leukemia viral oncogene                       homolog 3 (avian)       227   Protein   NP_001973   ERBB3   v-erb-b2 erythroblastic                       leukemia viral oncogene                       homolog 3 (avian)       228   DNA   NM_001938   DR1   down-regulator of transcription                       1, TBP-binding (negative                       cofactor 2)       229   Protein   NP_001929   DR1   down-regulator of transcription                       1, TBP-binding (negative                       cofactor 2)       230   DNA   NM_002448   MSX1   msh homeo box homolog 1                       ( Drosophila )       231   Protein   NP_002439   MSX1   msh homeo box homolog 1                       ( Drosophila )       232   DNA   NM_000127   EXT1   exostoses (multiple) 1       233   Protein   NP_000118   EXT1   exostoses (multiple) 1       234   DNA   NM_005760   CBF2   CCAAT-box-binding                       transcription factor       235   Protein   NP_005751   CBF2   CCAAT-box-binding                       transcription factor       236   DNA   NM_002825   PTN   pleiotrophin (heparin binding                       growth factor 8, neurite growth-                       promoting factor 1)       237   Protein   NP_002816   PTN   pleiotrophin (heparin binding                       growth factor 8, neurite growth-                       promoting factor 1)       238   DNA   NM_002715   PPP2CA   protein phosphatase 2 (formerly                       2A), catalytic subunit, alpha                       isoform       239   Protein   NP_002706   PPP2CA   protein phosphatase 2 (formerly                       2A), catalytic subunit, alpha                       isoform       240   DNA   NM_004555   NFATC3   nuclear factor of activated T-                       cells, cytoplasmic, calcineurin-                       dependent 3       241   Protein   NP_004546   NFATC3   nuclear factor of activated T-                       cells, cytoplasmic, calcineurin-                       dependent 3       242   DNA   NM_173163   NFATC3   nuclear factor of activated T-                       cells, cytoplasmic, calcineurin-                       dependent 3       243   Protein   NP_775186   NFATC3   nuclear factor of activated T-                       cells, cytoplasmic, calcineurin-                       dependent 3       244   DNA   NM_173164   NFATC3   nuclear factor of activated T-                       cells, cytoplasmic, calcineurin-                       dependent 3       245   Protein   NP_775187   NFATC3   nuclear factor of activated T-                       cells, cytoplasmic, calcineurin-                       dependent 3       246   DNA   NM_173165   NFATC3   nuclear factor of activated T-                       cells, cytoplasmic, calcineurin-                       dependent 3       247   Protein   NP_775188   NFATC3   nuclear factor of activated T-                       cells, cytoplasmic, calcineurin-                       dependent 3       248   DNA   NM_002295   LAMR1   laminin receptor 1 (ribosomal                       protein SA, 67 kDa)       249   Protein   NP_002286   LAMR1   laminin receptor 1 (ribosomal                       protein SA, 67 kDa)       250   DNA   NM_001634   AMD1   S-adenosylmethionine                       decarboxylase 1       251   Protein   NP_001625   AMD1   S-adenosylmethionine                       decarboxylase 1       252   DNA   NM_021960   MCL1   myeloid cell leukemia sequence                       1 (BCL2-related)       253   Protein   NP_068779   MCL1   myeloid cell leukemia sequence                       1 (BCL2-related)       254   DNA   HG4322-HT4592       Tubulin, Beta       255   DNA   NM_001022   RPS19   ribosomal protein S19       256   Protein   NP_001013   RPS19   ribosomal protein S19       257   DNA   NM_012185   FOXE2   forkhead box E2       258   Protein   NP_036317   FOXE2   forkhead box E2       259   DNA   M20812       Cluster Incl. M20812: Human                       kappa-immunoglobulin                       germline pseudogene (cos118)                       variable region (subgroup V                       kappa I) /cds = (6.326)                       /gb = M20812 /gi = 185958                       /ug = Hs.150224 /len = 351       260   Protein   AAA36095       Cluster Incl. M20812: Human                       kappa-immunoglobulin                       germline pseudogene (cos118)                       variable region (subgroup V                       kappa I) /cds = (6.326)                       /gb = M20812 /gi = 185958                       /ug = Hs.150224 /len = 351       261   DNA   AF068744       Cluster Incl. AF068744:  Homo                           sapiens  double homeodomain                       protein (DUX2) mRNA,                       complete cds /cds = (211.453)                       /gb = AF068744 /gi = 3414864                       /ug = Hs.157425 /len = 556       262   Protein   AF068744       Cluster Incl. AF068744:  Homo                 (Translation)         sapiens  double homeodomain                       protein (DUX2) mRNA,                       complete cds /cds = (211.453)                       /gb = AF068744 /gi = 3414864                       /ug = Hs.157425 /len = 556       263   DNA   NM_012369       Cluster Incl. AC004853:  Homo                           sapiens  PAC clone DJ0669B10                       from 7q33-q35 /cds = (0.953)                       /gb = AC004853 /gi = 3766130                       /ug = Hs.159899 /len = 954       264   Protein   NP_036501       Cluster Incl. AC004853:  Homo                           sapiens  PAC clone DJ0669B10                       from 7q33-q35 /cds = (0.953)                       /gb = AC004853 /gi = 3766130                       /ug = Hs.159899 /len = 954       265   DNA   W28732       Cluster Incl. W28732: 50h7                         Homo sapiens  cDNA                       /gb = W28732 /gi = 1308680                       /ug = Hs.177496 /len = 818       266   DNA   NM_005336   HDLBP   high density lipoprotein binding                       protein (vigilin)       267   Protein   NP_005327   HDLBP   high density lipoprotein binding                       protein (vigilin)       268   DNA   NM_000973   RPL8   ribosomal protein L8       269   Protein   NP_000964   RPL8   ribosomal protein L8       270   DNA   NM_033301   RPL8   ribosomal protein L8       271   DNA   NM_001013   RPS9   ribosomal protein S9       272   Protein   NP_001004   RPS9   ribosomal protein S9       273   DNA   M90356       Cluster Incl. M90356: Human                       BTF3 protein homologue gene,                       complete cds /cds = (0.644)                       /gb = M90356 /gi = 179575                       /ug = Hs.181967 /len = 645       274   Protein   M90356       Cluster Incl. M90356: Human               (Translation)       BTF3 protein homologue gene,                       complete cds /cds = (0.644)                       /gb = M90356 /gi = 179575                       /ug = Hs.181967 /len = 645       275   DNA   NM_002952   RPS2   ribosomal protein S2       276   Protein   NP_002943   RPS2   ribosomal protein S2       277   DNA   NM_001002   RPLP0   ribosomal protein, large, P0       278   Protein   NP_000993   RPLP0   ribosomal protein, large, P0       279   DNA   NM_053275   RPLP0   ribosomal protein, large, P0       280   DNA   NM_022551         Homo sapiens  ribosomal                       protein S18 (RPS18), mRNA       281   Protein   NP_072045         Homo sapiens  ribosomal                       protein S18 (RPS18)       282   DNA   NM_021109   TMSB4X   thymosin, beta 4, X                       chromosome       283   Protein   NP_066932   TMSB4X   thymosin, beta 4, X                       chromosome       284   DNA   NM_001014   RPS10   ribosomal protein S10       285   Protein   NP_001005   RPS10   ribosomal protein S10       286   DNA   NM_004095   EIF4EBP1   eukaryotic translation initiation                       factor 4E binding protein 1       287   Protein   NP_004086   EIF4EBP1   eukaryotic translation initiation                       factor 4E binding protein 1       288   DNA   NM_012231   PRDM2   PR domain containing 2, with                       ZNF domain       289   Protein   NP_036363   PRDM2   PR domain containing 2, with                       ZNF domain       290   DNA   NM_015866   PRDM2   PR domain containing 2, with                       ZNF domain       291   Protein   NP_056950   PRDM2   PR domain containing 2, with                       ZNF domain       292   DNA   AF047485   LOC90586   amine oxidase pseudogene       293   Protein   AF047485   LOC90586   amine oxidase pseudogene               (Translation)       294   DNA   NM_024407   NDUFS7   NADH dehydrogenase                       (ubiquinone) Fe—S protein 7,                       20 kDa (NADH-coenzyme Q                       reductase)       295   Protein   NP_077718   NDUFS7   NADH dehydrogenase                       (ubiquinone) Fe—S protein 7,                       20 kDa (NADH-coenzyme Q                       reductase)       296   DNA   NM_005271       Unknown (protein for                       MGC: 13241) [ Homo sapiens ],                       mRNA sequence       297   Protein   NP_005262       Unknown (protein for                       MGC: 13241) [ Homo sapiens ],                       mRNA sequence       298   DNA   NM_012084       Unknown (protein for                       MGC: 13241) [ Homo sapiens ],                       mRNA sequence       299   Protein   NP_036216       Unknown (protein for                       MGC: 13241) [ Homo sapiens ],                       mRNA sequence       300   DNA   U08997       Unknown (protein for                       MGC: 13241) [ Homo sapiens ],                       mRNA sequence       301   DNA   J04755       Cluster Incl. J04755: Human                       ferritin H processed                       pseudogene, complete cds                       /cds = UNKNOWN /gb = J04755                       /gi = 182512 /ug = Hs.239542                       /len = 2083       302   DNA   NM_003655   CBX4   chromobox homolog 4 (Pc                       class homolog,  Drosophila )       303   Protein   NP_003646   CBX4   chromobox homolog 4 (Pc                       class homolog,  Drosophila )       304   DNA   NM_014212   HOXC11   homeo box C11       305   Protein   NP_055027   HOXC11   homeo box C11       306   DNA   W28912       ESTs       307   DNA   NM_005160   ADRBK2   adrenergic, beta, receptor                       kinase 2       308   Protein   NP_005151   ADRBK2   adrenergic, beta, receptor                       kinase 2       309   DNA   NM_006026   H1FX   H1 histone family, member X       310   Protein   NP_006017   H1FX   H1 histone family, member X       311   DNA   NM_015062   KIAA0595   KIAA0595 protein       312   Protein   NP_055877   KIAA0595   KIAA0595 protein       313   DNA   NM_001498   GCLC   glutamate-cysteine ligase,                       catalytic subunit       314   Protein   NP_001489   GCLC   glutamate-cysteine ligase,                       catalytic subunit       315   DNA   AL050390   DKFZP564O043   hypothetical protein                       DKFZp564O043       316   DNA   NM_003797   EED   embryonic ectoderm                       development       317   Protein   NP_003788   EED   embryonic ectoderm                       development       318   DNA   NM_152991   EED   embryonic ectoderm                       development       319   Protein   NP_694536   EED   embryonic ectoderm                       development       320   DNA   NM_005796   NUTF2   nuclear transport factor 2       321   Protein   NP_005787   NUTF2   nuclear transport factor 2       322   DNA   NM_003876   PMI   putative receptor protein       323   Protein   NP_003867   PMI   putative receptor protein       324   DNA   D80001   KIAA0179   KIAA0179 protein       325   Protein   D80001 (Translation)   KIAA0179   KIAA0179 protein       326   DNA   NM_005792   MPHOSPH6   M-phase phosphoprotein 6       327   Protein   NP_005783   MPHOSPH6   M-phase phosphoprotein 6       328   DNA   NM_006716   ASK   activator of S phase kinase       329   Protein   NP_006707   ASK   activator of S phase kinase       330   DNA   NM_001812   CENPC1   centromere protein C 1       331   Protein   NP_001803   CENPC1   centromere protein C 1       332   DNA   NM_001186   BACH1   BTB and CNC homology 1,                       basic leucine zipper                       transcription factor 1       333   Protein   NP_001177   BACH1   BTB and CNC homology 1,                       basic leucine zipper                       transcription factor 1       334   DNA   NM_014673   KIAA0103   KIAA0103 gene product       335   Protein   NP_055488   KIAA0103   KIAA0103 gene product       336   DNA   NM_001537   HSBP1   heat shock factor binding                       protein 1       337   Protein   NP_001528   HSBP1   heat shock factor binding                       protein 1       338   DNA   NM_001024   RPS21   ribosomal protein S21       339   Protein   NP_001015   RPS21   ribosomal protein S21       340   DNA   NM_001003   RPLP1   ribosomal protein, large, P1       341   Protein   NP_000994   RPLP1   ribosomal protein, large, P1       342   DNA   NM_000998   RPL37A   ribosomal protein L37a       343   Protein   NP_000989   RPL37A   ribosomal protein L37a       344   DNA   AL049430         Homo sapiens  mRNA; cDNA                       DKFZp586H201 (from clone                       DKFZp586H201), mRNA                       sequence       345   DNA   NM_030756   TCF7L2   transcription factor 7-like 2 (T-                       cell specific, HMG-box)       346   Protein   NP_110383   TCF7L2   transcription factor 7-like 2 (T-                       cell specific, HMG-box)       347   DNA   NM_014247   PDZ-GEF1   PDZ domain containing                       guanine nucleotide exchange                       factor(GEF)1       348   Protein   NP_055062   PDZ-GEF1   PDZ domain containing                       guanine nucleotide exchange                       factor(GEF)1       349   DNA   NM_000303   PMM2   phosphomannomutase 2       350   Protein   NP_000294   PMM2   phosphomannomutase 2       351   DNA   NM_022719   DGCR14   DiGeorge syndrome critical                       region gene 14       352   Protein   NP_073210   DGCR14   DiGeorge syndrome critical                       region gene 14       353   DNA   NM_007042   RPP14   ribonuclease P (14 kD)       354   Protein   NP_008973   RPP14   ribonuclease P (14 kD)       355   DNA   NM_014671   KIAA0010   ubiquitin-protein isopeptide                       ligase (E3)       356   Protein   NP_055486   KIAA0010   ubiquitin-protein isopeptide                       ligase (E3)       357   DNA   NM_004854   HNK-1ST   HNK-1 sulfotransferase       358   Protein   NP_004845   HNK-1ST   HNK-1 sulfotransferase       359   DNA   NM_004330   BNIP2   BCL2/adenovirus E1B 19 kDa                       interacting protein 2       360   Protein   NP_004321   BNIP2   BCL2/adenovirus E1B 19 kDa                       interacting protein 2       361   DNA   AB002293   KIAA0295   KIAA0295 protein       362   Protein   AB002293   KIAA0295   KIAA0295 protein               (Translation)       363   DNA   AB023198   KIAA0981   KIAA0981 protein       364   Protein   AB023198   KIAA0981   KIAA0981 protein               (Translation)       365   DNA   AB007915   KIAA0446   KIAA0446 gene product       366   Protein   AB007915   KIAA0446   KIAA0446 gene product               (Translation)       367   DNA   NM_004273   CHST3   carbohydrate (chondroitin 6)                       sulfotransferase 3       368   Protein   NP_004264   CHST3   carbohydrate (chondroitin 6)                       sulfotransferase 3       369   DNA   NM_014363   SACS   spastic ataxia of Charlevoix-                       Saguenay (sacsin)       370   Protein   NP_055178   SACS   spastic ataxia of Charlevoix-                       Saguenay (sacsin)       371   DNA   NM_000094   COL7A1   collagen, type VII, alpha 1                       (epidermolysis bullosa,                       dystrophic, dominant and                       recessive)       372   Protein   NP_000085   COL7A1   collagen, type VII, alpha 1                       (epidermolysis bullosa,                       dystrophic, dominant and                       recessive)       373   DNA   AA928996   THOC2   THO complex 2       374   DNA   AL079314   ZNF364   zinc finger protein 364       375   Protein   AL079314   ZNF364   zinc finger protein 364               (Translation)       376   DNA   NM_015641   TES   testis derived transcript (3 LIM                       domains)       377   Protein   NP_056456   TES   testis derived transcript (3 LIM                       domains)       378   DNA   NM_152829   TES   testis derived transcript (3 LIM                       domains)       379   Protein   NP_690042   TES   testis derived transcript (3 LIM                       domains)       380   DNA   NM_002856   PVRL2   poliovirus receptor-related 2                       (herpesvirus entry mediator B)       381   Protein   NP_002847   PVRL2   poliovirus receptor-related 2                       (herpesvirus entry mediator B)       382   DNA   AI817548       Cluster Incl.                       AI817548: wk24e08.x1  Homo                           sapiens  cDNA, 3′ end                       /clone = IMAGE-2413286                       /clone_end = 3′ /gb = AI817548                       /gi = 5436627 /ug = Hs.184093                       /len = 570       383   DNA   NM_015002   FBXO21   F-box only protein 21       384   Protein   NP_055817   FBXO21   F-box only protein 21       385   DNA   NM_033624   FBXO21   F-box only protein 21       386   Protein   NP_296373   FBXO21   F-box only protein 21       387   DNA   NM_001788   CDC10   CDC10 cell division cycle 10                       homolog ( S. cerevisiae )       388   Protein   NP_001779   CDC10   CDC10 cell division cycle 10                       homolog ( S. cerevisiae )       389   DNA   NM_006989   CAPRI   Ca2+-promoted Ras inactivator       390   Protein   NP_008920   CAPRI   Ca2+-promoted Ras inactivator       391   DNA   NM_003704   RES4-22   gene with multiple splice                       variants near HD locus on                       4p16.3       392   Protein   NP_003695   RES4-22   gene with multiple splice                       variants near HD locus on                       4p16.3       393   DNA   NM_007144   ZNF144   zinc finger protein 144 (Mel-                       18       394   Protein   NP_009075   ZNF144   zinc finger protein 144 (Mel-                       18)       395   DNA   AL049450         Homo sapiens  mRNA; cDNA                       DKFZp586B1922 (from clone                       DKFZp586B1922), mRNA                       sequence       396   DNA   NM_014686   KIAA0355   KIAA0355 gene product       397   Protein   NP_055501   KIAA0355   KIAA0355 gene product       398   DNA   NM_005837   RPP20   POP7 (processing of precursor,                         S. cerevisiae ) homolog       399   Protein   NP_005828   RPP20   POP7 (processing of precursor,                         S. cerevisiae ) homolog       400   DNA   NM_004786   TXNL   thioredoxin-like, 32 kDa       401   Protein   NP_004777   TXNL   thioredoxin-like, 32 kDa       402   DNA   NM_030809   C12orf22   chromosome 12 open reading                       frame 22       403   Protein   NP_110436   C12orf22   chromosome 12 open reading                       frame 22       404   DNA   NM_012290   TLK1   tousled-like kinase 1       405   Protein   NP_036422   TLK1   tousled-like kinase 1       406   DNA   NM_005047   PSMD5   proteasome (prosome,                       macropain) 26S subunit, non-                       ATPase, 5       407   Protein   NP_005038   PSMD5   proteasome (prosome,                       macropain) 26S subunit, non-                       ATPase, 5       408   DNA   NM_003218   TERF1   telomeric repeat binding factor                       (NIMA-interacting) 1       409   Protein   NP_003209   TERF1   telomeric repeat binding factor                       (NIMA-interacting) 1       410   DNA   NM_017489   TERF1   telomeric repeat binding factor                       (NIMA-interacting) 1       411   Protein   NP_059523   TERF1   telomeric repeat binding factor                       (NIMA-interacting) 1       412   DNA   NM_001991   EZH1   enhancer of zeste homolog 1                       ( Drosophila )       413   Protein   NP_001982   EZH1   enhancer of zeste homolog 1                       ( Drosophila )       414   DNA   NM_003768   PEA15   phosphoprotein enriched in                       astrocytes 15       415   Protein   NP_003759   PEA15   phosphoprotein enriched in                       astrocytes 15       416   DNA   NM_013287   PEA15   phosphoprotein enriched in                       astrocytes 15       417   DNA   NM_023005   BAZ1B   bromodomain adjacent to zinc                       finger domain, 1B       418   Protein   NP_075381   BAZ1B   bromodomain adjacent to zinc                       finger domain, 1B       419   DNA   NM_032408   BAZ1B   bromodomain adjacent to zinc                       finger domain, 1B       420   Protein   NP_115784   BAZ1B   bromodomain adjacent to zinc                       finger domain, 1B       421   DNA   NM_015935   CGI-01   CGI-01 protein       422   Protein   NP_057019   CGI-01   CGI-01 protein       423   DNA   AF052148         Homo sapiens  clone 24507                       mRNA sequence       424   DNA   NM_000994   RPL32   ribosomal protein L32       425   Protein   NP_000985   RPL32   ribosomal protein L32       426   DNA   NM_005395   PMS2L9   postmeiotic segregation                       increased 2-like 9       427   Protein   NP_005386   PMS2L9   postmeiotic segregation                       increased 2-like 9       428   DNA   NM_003289   TPM2   tropomyosin 2 (beta)       429   Protein   NP_003280   TPM2   tropomyosin 2 (beta)       430   DNA   NM_001026   RPS24   ribosomal protein S24       431   Protein   NP_001017   RPS24   ribosomal protein S24       432   DNA   NM_033022   RPS24   ribosomal protein S24       433   Protein   NP_148982   RPS24   ribosomal protein S24       434   DNA   NM_001101   ACTB   actin, beta       435   Protein   NP_001092   ACTB   actin, beta       436   DNA   NM_001015   RPS11   ribosomal protein S11       437   Protein   NP_001006   RPS11   ribosomal protein S11       438   DNA   NM_013410   AK3   adenylate kinase 3       439   Protein   NP_037542   AK3   adenylate kinase 3       440   DNA   NM_000034   ALDOA   aldolase A, fructose-                       bisphosphate       441   Protein   NP_000025   ALDOA   aldolase A, fructose-                       bisphosphate       442   DNA   NM_000982   RPL21   ribosomal protein L21       443   Protein   NP_000973   RPL21   ribosomal protein L21       444   DNA   NM_004559   NSEP1   nuclease sensitive element                       binding protein 1       445   Protein   NP_004550   NSEP1   nuclease sensitive element                       binding protein 1       446   DNA   NM_000984   RPL23A   ribosomal protein L23a       447   Protein   NP_000975   RPL23A   ribosomal protein L23a       448   DNA   NM_000498   CYP11B2   cytochrome P450, subfamily                       XIB (steroid 11-beta-                       hydroxylase), polypeptide 2       449   Protein   NP_000489   CYP11B2   cytochrome P450, subfamily                       XIB (steroid 11-beta-                       hydroxylase), polypeptide 2       450   DNA   NM_002654   PKM2   pyruvate kinase, muscle       451   Protein   NP_002645   PKM2   pyruvate kinase, muscle       452   DNA   W25892   EST   EST       453   DNA   NM_000990   RPL27A   ribosomal protein L27a       454   Protein   NP_000981   RPL27A   ribosomal protein L27a       455   DNA   NM_001009   RPS5   ribosomal protein S5       456   Protein   NP_001000   RPS5   ribosomal protein S5       457   DNA   NM_001023   RPS20   ribosomal protein S20       458   Protein   NP_001014   RPS20   ribosomal protein S20       459   DNA   NM_001905   CTPS   CTP synthase       460   Protein   NP_001896   CTPS   CTP synthase       461   DNA   NM_021104   RPL41   ribosomal protein L41       462   Protein   NP_066927   RPL41   ribosomal protein L41       463   DNA   NM_002235   KCNA6   potassium voltage-gated                       channel, shaker-related                       subfamily, member 6       464   Protein   NP_002226   KCNA6   potassium voltage-gated                       channel, shaker-related                       subfamily, member 6       465   DNA   NM_001004   RPLP2   ribosomal protein, large P2       466   Protein   NP_000995   RPLP2   ribosomal protein, large P2       467   DNA   NM_002268   RPLP2   ribosomal protein, large P2       468   Protein   NP_002259   RPLP2   ribosomal protein, large P2       469   DNA   NM_032771   RPLP2   ribosomal protein, large P2       470   Protein   NP_116160   RPLP2   ribosomal protein, large P2       471   DNA   AL096857   KIAA1096   KIAA1096 protein       472   Protein   AL096857   KIAA1096   KIAA1096 protein               (Translation)       473   DNA   AI498132         Homo sapiens  cDNA FLJ37094                       fis, clone BRACE2018337,                       mRNA sequence       474   DNA   NM_005382   NEF3   neurofilament 3 (150 kDa                       medium)       475   Protein   NP_005373   NEF3   neurofilament 3 (150 kDa                       medium)       476   DNA   NM_014296   CAPN7   calpain 7       477   Protein   NP_055111   CAPN7   calpain 7       478   DNA   NM_006012   CLPP   ClpP caseinolytic protease,                       ATP-dependent, proteolytic                       subunit homolog ( E. coli )       479   Protein   NP_006003   CLPP   ClpP caseinolytic protease,                       ATP-dependent, proteolytic                       subunit homolog ( E. coli )       480   DNA   NM_000138   FBN1   fibrillin 1 (Marfan syndrome)       481   Protein   NP_000129   FBN1   fibrillin 1 (Marfan syndrome)       482   DNA   NM_006710   COP9   COP9 homolog       483   Protein   NP_006701   COP9   COP9 homolog       484   DNA   NM_012425   RSU1   Ras suppressor protein 1       485   Protein   NP_036557   RSU1   Ras suppressor protein 1       486   DNA   NM_012321   LSM4   U6 snRNA-associated Sm-like                       protein       487   Protein   NP_036453   LSM4   U6 snRNA-associated Sm-like                       protein       488   DNA   NM_000430   PAFAH1B1   platelet-activating factor                       acetylhydrolase, isoform Ib,                       alpha subunit 45 kDa       489   Protein   NP_000421   PAFAH1B1   platelet-activating factor                       acetylhydrolase, isoform Ib,                       alpha subunit 45 kDa       490   DNA   D86971   KIAA0217   KIAA0217 protein       491   Protein   D86971 (Translation)   KIAA0217   KIAA0217 protein       492   DNA   NM_006887   ZFP36L2   zinc finger protein 36, C3H                       type-like 2       493   Protein   NP_008818   ZFP36L2   zinc finger protein 36, C3H                       type-like 2       494   DNA   NM_005483   CHAF1A   chromatin assembly factor 1,                       subunit A (p150)       495   Protein   NP_005474   CHAF1A   chromatin assembly factor 1,                       subunit A (p150)       496   DNA   AF000560         Homo sapiens , clone                       IMAGE: 4477095, mRNA,                       mRNA sequence       497   Protein   AAB58413         Homo sapiens , clone                       IMAGE: 4477095, mRNA,                       mRNA sequence       498   DNA   NM_002567   PBP   prostatic binding protein       499   Protein   NP_002558   PBP   prostatic binding protein       500   DNA   NM_015906   TRIM33   tripartite motif-containing 33       501   Protein   NP_056990   TRIM33   tripartite motif-containing 33       502   DNA   NM_033020   TRIM33   tripartite motif-containing 33       503   Protein   NP_148980   TRIM33   tripartite motif-containing 33       504   DNA   NM_006696   SMAP   skeletal muscle abundant                       protein       505   Protein   NP_006687   SMAP   skeletal muscle abundant                       protein       506   DNA   NM_015636   EIF2B4   eukaryotic translation initiation                       factor 2B, subunit 4 delta,                       67 kDa       507   Protein   NP_056451   EIF2B4   eukaryotic translation initiation                       factor 2B, subunit 4 delta,                       67 kDa       508   DNA   NM_006195   PBX3   pre-B-cell leukemia                       transcription factor 3       509   Protein   NP_006186   PBX3   pre-B-cell leukemia                       transcription factor 3       510   DNA   NM_003325   HIRA   HIR histone cell cycle                       regulation defective homolog A                       ( S. cerevisiae )       511   Protein   NP_003316   HIRA   HIR histone cell cycle                       regulation defective homolog A                       ( S. cerevisiae )       512   DNA   NM_001324   CSTF1   cleavage stimulation factor, 3′                       pre-RNA, subunit 1, 50 kDa       513   Protein   NP_001315   CSTF1   cleavage stimulation factor, 3′                       pre-RNA, subunit 1, 50 kDa       514   DNA   NM_006246   PPP2R5E   protein phosphatase 2,                       regulatory subunit B (B56),                       epsilon isoform       515   Protein   NP_006237   PPP2R5E   protein phosphatase 2,                       regulatory subunit B (B56),                       epsilon isoform       516   DNA   AB023148   KIAA0931   KIAA0931 protein       517   Protein   AB023148   KIAA0931   KIAA0931 protein               (Translation)       518   DNA   NM_003610   RAE1   RAE1 RNA export 1 homolog                       ( S. pombe )       519   Protein   NP_003601   RAE1   RAE1 RNA export 1 homolog                       ( S. pombe )       520   DNA   NM_001469   G22P1   thyroid autoantigen 70 kDa (Ku                       antigen)       521   Protein   NP_001460   G22P1   thyroid autoantigen 70 kDa (Ku                       antigen)       522   DNA   NM_003035   SIL   TAL1 (SCL) interrupting locus       523   Protein   NP_003026   SIL   TAL1 (SCL) interrupting locus       524   DNA   NM_030794   FLJ21007   hypothetical protein FLJ21007       525   Protein   NP_110421   FLJ21007   hypothetical protein FLJ21007       526   DNA   NM_006267   RANBP2   RAN binding protein 2       527   Protein   NP_006258   RANBP2   RAN binding protein 2       528   DNA   L19183   MAC30   hypothetical protein MAC30       529   Protein   L19183 (Translation)   MAC30   hypothetical protein MAC30       530   DNA   AF004292   DKFZP566C134   DKFZP566C134 protein       531   DNA   AL118582       OVN6-2 [ Homo sapiens ],                       mRNA sequence       532   DNA   NM_003021   SGT   small glutamine-rich                       tetratricopeptide repeat (TPR)-                       containing       533   Protein   NP_003012   SGT   small glutamine-rich                       tetratricopeptide repeat (TPR)-                       containing       534   DNA   NM_005882   MAEA   macrophage erythroblast                       attacher       535   Protein   NP_005873   MAEA   macrophage erythroblast                       attacher       536   DNA   NM_006411   AGPAT1   1-acylglycerol-3-phosphate O-                       acyltransferase 1                       (lysophosphatidic acid                       acyltransferase, alpha)       537   Protein   NP_006402   AGPAT1   1-acylglycerol-3-phosphate O-                       acyltransferase 1                       (lysophosphatidic acid                       acyltransferase, alpha)       538   DNA   NM_032741   AGPAT1   1-acylglycerol-3-phosphate O-                       acyltransferase 1                       (lysophosphatidic acid                       acyltransferase, alpha)       539   DNA   NM_014820   TOMM70A   translocase of outer                       mitochondrial membrane 70                       homolog A (yeast)       540   Protein   NP_055635   TOMM70A   translocase of outer                       mitochondrial membrane 70                       homolog A (yeast)       541   DNA   NM_012300   FBXW1B   F-box and WD-40 domain                       protein 1B       542   Protein   NP_036432   FBXW1B   F-box and WD-40 domain                       protein 1B       543   DNA   NM_033644   FBXW1B   F-box and WD-40 domain                       protein 1B       544   Protein   NP_387448   FBXW1B   F-box and WD-40 domain                       protein 1B       545   DNA   NM_033645   FBXW1B   F-box and WD-40 domain                       protein 1B       546   Protein   NP_387449   FBXW1B   F-box and WD-40 domain                       protein 1B       547   DNA   NM_016936   UBN1   ubinuclein 1       548   Protein   NP_058632   UBN1   ubinuclein 1       549   DNA   NM_006950   SYN1   synapsin I       550   Protein   NP_008881   SYN1   synapsin I       551   DNA   NM_133499   SYN1   synapsin I       552   Protein   NP_598006   SYN1   synapsin I       553   DNA   NM_153208   MGC35048   hypothetical protein                       MGC35048       554   Protein   NP_694940   MGC35048   hypothetical protein                       MGC35048       555   DNA   NM_014282   HABP4   hyaluronan binding protein 4       556   Protein   NP_055097   HABP4   hyaluronan binding protein 4       557   DNA   AF035314         Homo sapiens  clone 23651                       mRNA sequence       558   DNA   NM_003637   ITGA10   integrin, alpha 10       559   Protein   NP_003628   ITGA10   integrin, alpha 10       560   DNA   NM_001016   RPS12   ribosomal protein S12       561   Protein   NP_001007   RPS12   ribosomal protein S12       562   DNA   L10379   HRIHFB2206   HRIHFB2206 protein       563   DNA   NM_003107   SOX4   SRY (sex determining region                       Y)-box 4       564   Protein   NP_003098   SOX4   SRY (sex determining region                       Y)-box 4       565   DNA   NM_003056   SLC19A1   solute carrier family 19 (folate                       transporter), member 1       566   Protein   NP_003047   SLC19A1   solute carrier family 19 (folate                       transporter), member 1       567   DNA   NM_006831   HEAB   ATP/GTP-binding protein       568   Protein   NP_006822   HEAB   ATP/GTP-binding protein       569   DNA   NM_020368   SAS10   disrupter of silencing 10       570   Protein   NP_065101   SAS10   disrupter of silencing 10       571   DNA   NM_002061   GCLM   glutamate-cysteine ligase,                       modifier subunit       572   Protein   NP_002052   GCLM   glutamate-cysteine ligase,                       modifier subunit       573   DNA   NM_018121   C10ORF6   hypothetical protein FLJ10512       574   Protein   NP_060591   C10ORF6   hypothetical protein FLJ10512       575   DNA   NM_144592   C10ORF6   hypothetical protein FLJ10512       576   Protein   NP_653193   C10ORF6   hypothetical protein FLJ10512       577   DNA   NM_006165   NFRKB   nuclear factor related to kappa                       B binding protein       578   Protein   NP_006156   NFRKB   nuclear factor related to kappa                       B binding protein       579   DNA   NM_004587   RRBP1   ribosome binding protein 1                       homolog 180 kDa (dog)       580   Protein   NP_004578   RRBP1   ribosome binding protein 1                       homolog 180 kDa (dog)       581   DNA   AA887480   KIAA0117   KIAA0117 protein       582   DNA   NM_014788   TRIM14   tripartite motif-containing 14       583   Protein   NP_055603   TRIM14   tripartite motif-containing 14       584   DNA   NM_033219   TRIM14   tripartite motif-containing 14       585   DNA   NM_033220   TRIM14   tripartite motif-containing 14       586   DNA   NM_033221   TRIM14   tripartite motif-containing 14       587   Protein   NP_150090   TRIM14   tripartite motif-containing 14       588   DNA   NM_003705   SLC25A12   solute carrier family 25                       (mitochondrial carrier, Aralar),                       member 12       589   Protein   NP_003696   SLC25A12   solute carrier family 25                       (mitochondrial carrier, Aralar),                       member 12       590   DNA   NM_021983   HLA-DRB4   major histocompatibility                       complex, class II, DR beta 4       591   Protein   NP_068818   HLA-DRB4   major histocompatibility                       complex, class II, DR beta 4       592   DNA   NM_015004   KIAA0116   KIAA0116 protein       593   Protein   NP_055819   KIAA0116   KIAA0116 protein       594   DNA   NM_015703   CGI-96   CGI-96 protein       595   Protein   NP_056518   CGI-96   CGI-96 protein       596   DNA   NM_000181   GUSB   glucuronidase, beta       597   Protein   NP_000172   GUSB   glucuronidase, beta       598   DNA   NM_014509         Homo sapiens  kraken-like                       (dJ222E13.1), mRNA       599   Protein   NP_055324         Homo sapiens  kraken-like                       (dJ222E13.1)       600   DNA   NM_004290   RNF14   ring finger protein 14       601   Protein   NP_004281   RNF14   ring finger protein 14       602   DNA   NM_002254   KIF3C   kinesin family member 3C       603   Protein   NP_002245   KIF3C   kinesin family member 3C       604   DNA   NM_003205   TCF12   transcription factor 12 (HTF4,                       helix-loop-helix transcription                       factors 4)       605   Protein   NP_003196   TCF12   transcription factor 12 (HTF4,                       helix-loop-helix transcription                       factors 4)       606   DNA   NM_005875   GC20   translation factor suil homolog       607   Protein   NP_005866   GC20   translation factor suil homolog       608   DNA   NM_022739   SMURF2   E3 ubiquitin ligase SMURF2       609   Protein   NP_073576   SMURF2   E3 ubiquitin ligase SMURF2       610   DNA   NM_012308   FBXL11   F-box and leucine-rich repeat                       protein 11       611   Protein   NP_036440   FBXL11   F-box and leucine-rich repeat                       protein 11       612   DNA   NM_014952   KIAA0945   KIAA0945 protein       613   Protein   NP_055767   KIAA0945   KIAA0945 protein       614   DNA   NM_004793   PRSS15   protease, serine, 15       615   Protein   NP_004784   PRSS15   protease, serine, 15       616   DNA   NM_015384   IDN3   IDN3 protein       617   Protein   NP_056199   IDN3   IDN3 protein       618   DNA   NM_133433   IDN3   IDN3 protein       619   Protein   NP_597677   IDN3   IDN3 protein       620   DNA   NM_006999   POLS   polymerase (DNA directed)                       sigma       621   Protein   NP_008930   POLS   polymerase (DNA directed)                       sigma       622   DNA   NM_005318       Cluster Incl. Z97630: Human                       DNA sequence from clone                       466N1 on chromosome 22q12-13                       Contains H1F0(H1 histone                       family, member 0) gene, 2-                       amino-3-ketobutyrate-CoA                       ligase(nuclear gene encoding                       mitochondrial protein), GALR3                       (galanin receptor) gene, ESTs,                       GSSs an       623   Protein   NP_005309       Cluster Incl. Z97630: Human                       DNA sequence from clone                       466N1 on chromosome 22q12-13                       Contains H1F0(H1 histone                       family, member 0) gene, 2-                       amino-3-ketobutyrate-CoA                       ligase(nuclear gene encoding                       mitochondrial protein), GALR3                       (galanin receptor) gene, ESTs,                       GSSs an       624   DNA   NM_000852   GSTP1   glutathione S-transferase pi       625   Protein   NP_000843   GSTP1   glutathione S-transferase pi       626   DNA   NM_015607   DKFZP547E1010   DKFZP547E1010 protein       627   Protein   NP_056422   DKFZP547E1010   DKFZP547E1010 protein       628   DNA   AL096752         Homo sapiens  mRNA; cDNA                       DKFZp434A012 (from clone                       DKFZp434A012), mRNA                       sequence       629   DNA   NM_000983   RPL22   ribosomal protein L22       630   Protein   NP_000974   RPL22   ribosomal protein L22       631   DNA   NM_005269   GLI   glioma-associated oncogene                       homolog (zinc finger protein)       632   Protein   NP_005260   GLI   glioma-associated oncogene                       homolog (zinc finger protein)       633   DNA   NM_000968   RPL4   ribosomal protein L4       634   Protein   NP_000959   RPL4   ribosomal protein L4       635   DNA   NM_000838   GRM1   glutamate receptor,                       metabotropic 1       636   Protein   NP_000829   GRM1   glutamate receptor,                       metabotropic 1       637   DNA   NM_000704   ATP4A   ATPase, H+/K+ exchanging,                       alpha polypeptide       638   Protein   NP_000695   ATP4A   ATPase, H+/K+ exchanging,                       alpha polypeptide       639   DNA   NM_006213   PHKG1   phosphorylase kinase, gamma 1                       (muscle)       640   Protein   NP_006204   PHKG1   phosphorylase kinase, gamma 1                       (muscle)       641   DNA   NM_001060   TBXA2R   thromboxane A2 receptor       642   Protein   NP_001051   TBXA2R   thromboxane A2 receptor       643   DNA   NM_000980   RPL18A   ribosomal protein L18a       644   Protein   NP_000971   RPL18A   ribosomal protein L18a       645   DNA   NM_000405   GM2A   GM2 ganglioside activator                       protein       646   Protein   NP_000396   GM2A   GM2 ganglioside activator                       protein       647   DNA   NM_000997   RPL37   ribosomal protein L37       648   Protein   NP_000988   RPL37   ribosomal protein L37       649   DNA   NM_003431   ZNF124   zinc finger protein 124 (HZF-                       16)       650   Protein   NP_003422   ZNF124   zinc finger protein 124 (HZF-                       16)       651   DNA   NM_005507   CFL1   cofilin 1 (non-muscle)       652   Protein   NP_005498   CFL1   cofilin 1 (non-muscle)       653   DNA   NM_021130   PPIA   peptidylprolyl isomerase A                       (cyclophilin A)       654   Protein   NP_066953   PPIA   peptidylprolyl isomerase A                       (cyclophilin A)       655   DNA   NM_000976   RPL12   ribosomal protein L12       656   Protein   NP_000967   RPL12   ribosomal protein L12       657   DNA   NM_000992   RPL29   ribosomal protein L29       658   Protein   NP_000983   RPL29   ribosomal protein L29       659   DNA   NM_000993   RPL31   ribosomal protein L31       660   Protein   NP_000984   RPL31   ribosomal protein L31       661   DNA   D50525       Cluster Incl. D50525: Human                       mRNA for TI-227H                       /cds = UNKNOWN/gb = D50525                       /gi = 1167502 /ug = Hs.184914                       /len = 3911       662   DNA   NM_001355   DDT   D-dopachrome tautomerase       663   Protein   NP_001346   DDT   D-dopachrome tautomerase       664   DNA   NM_005834   TIMM17B   translocase of inner                       mitochondrial membrane 17                       homolog B (yeast)       665   Protein   NP_005825   TIMM17B   translocase of inner                       mitochondrial membrane 17                       homolog B (yeast)       666   DNA   NM_007294   BRCA1   breast cancer 1, early onset       667   Protein   NP_009225   BRCA1   breast cancer 1, early onset       668   DNA   NM_007295   BRCA1   breast cancer 1, early onset       669   DNA   NM_007296   BRCA1   breast cancer 1, early onset       670   DNA   NM_007297   BRCA1   breast cancer 1, early onset       671   Protein   NP_009228   BRCA1   breast cancer 1, early onset       672   DNA   NM_007298   BRCA1   breast cancer 1, early onset       673   Protein   NP_009229   BRCA1   breast cancer 1, early onset       674   DNA   NM_004805   POLR2D   polymerase (RNA) II (DNA                       directed) polypeptide D       675   Protein   NP_004796   POLR2D   polymerase (RNA) II (DNA                       directed) polypeptide D       676   DNA   NM_015487   GEMIN4   gem (nuclear organelle)                       associated protein 4       677   Protein   NP_056302   GEMIN4   gem (nuclear organelle)                       associated protein 4       678   DNA   NM_015721   GEMIN4   gem (nuclear organelle)                       associated protein 4       679   DNA   AJ006835   RNU17D   RNA, U17D small nucleolar       680   DNA   NM_031246   PSG2   pregnancy specific beta-1-                       glycoprotein 2       681   Protein   NP_112536   PSG2   pregnancy specific beta-1-                       glycoprotein 2       682   DNA   NM_004565   PEX14   peroxisomal biogenesis factor                       14       683   Protein   NP_004556   PEX14   peroxisomal biogenesis factor                       14       684   DNA   NM_001228   CASP8   caspase 8, apoptosis-related                       cysteine protease       685   Protein   NP_001219   CASP8   caspase 8, apoptosis-related                       cysteine protease       686   DNA   NM_033355   CASP8   caspase 8, apoptosis-related                       cysteine protease       687   Protein   NP_203519   CASP8   caspase 8, apoptosis-related                       cysteine protease       688   DNA   NM_033356   CASP8   caspase 8, apoptosis-related                       cysteine protease       689   Protein   NP_203520   CASP8   caspase 8, apoptosis-related                       cysteine protease       690   DNA   NM_033357   CASP8   caspase 8, apoptosis-related                       cysteine protease       691   Protein   NP_203521   CASP8   caspase 8, apoptosis-related                       cysteine protease       692   DNA   NM_033358   CASP8   caspase 8, apoptosis-related                       cysteine protease       693   Protein   NP_203522   CASP8   caspase 8, apoptosis-related                       cysteine protease       694   DNA   NM_001061   TBXAS1   thromboxane A synthase 1                       (platelet, cytochrome P450,                       subfamily V)       695   Protein   NP_001052   TBXAS1   thromboxane A synthase 1                       (platelet, cytochrome P450,                       subfamily V)       696   DNA   NM_030984   TBXAS1   thromboxane A synthase 1                       (platelet, cytochrome P450,                       subfamily V)       697   Protein   NP_112246   TBXAS1   thromboxane A synthase 1                       (platelet, cytochrome P450,                       subfamily V)       698   DNA   NM_004901   LYSAL1   lysosomal apyrase-like 1       699   Protein   NP_004892   LYSAL1   lysosomal apyrase-like 1       700   DNA   X98494   MPHOSPH10   M-phase phosphoprotein 10                       (U3 small nucleolar                       ribonucleoprotein)       701   Protein   X98494 (Translation)   MPHOSPH10   M-phase phosphoprotein 10                       (U3 small nucleolar                       ribonucleoprotein)       702   DNA   NM_017575   C17orf31   chromosome 17 open reading                       frame 31       703   Protein   NP_060045   C17orf31   chromosome 17 open reading                       frame 31       704   DNA   NM_001116   ADCY9   adenylate cyclase 9       705   Protein   NP_001107   ADCY9   adenylate cyclase 9       706   DNA   NM_014810   CAP350   centrosome-associated protein                       350       707   Protein   NP_055625   CAP350   centrosome-associated protein                       350       708   DNA   NM_005884   PAK4   p21(CDKN1A)-activated                       kinase 4       709   Protein   NP_005875   PAK4   p21(CDKN1A)-activated                       kinase 4       710   DNA   NM_000373   UMPS   uridine monophosphate                       synthetase (orotate                       phosphoribosyl transferase and                       orotidine-5′-decarboxylase)       711   Protein   NP_000364   UMPS   uridine monophosphate                       synthetase (orotate                       phosphoribosyl transferase and                       orotidine-5′-decarboxylase)       712   DNA   NM_002273   KRT8   keratin 8       713   Protein   NP_002264   KRT8   keratin 8       714   DNA   NM_006985   NPIP   nuclear pore complex                       interacting protein       715   Protein   NP_008916   NPIP   nuclear pore complex                       interacting protein       716   DNA   NM_004064   CDKN1B   cyclin-dependent kinase                       inhibitor 1B (p27, Kip1)       717   Protein   NP_004055   CDKN1B   cyclin-dependent kinase                       inhibitor 1B (p27, Kip1)       718   DNA   NM_020765   RBAF600   retinoblastoma-associated                       factor 600       719   Protein   NP_065816   RBAF600   retinoblastoma-associated                       factor 600       720   DNA   AI123426       EST       721   DNA   NM_005997   TCFL1   transcription factor-like 1       722   Protein   NP_005988   TCFL1   transcription factor-like 1       723   DNA   NM_005866   SR-BP1   type I sigma receptor       724   Protein   NP_005857   SR-BP1   type I sigma receptor       725   DNA   NM_147157   SR-BP1   type I sigma receptor       726   Protein   NP_671513   SR-BP1   type I sigma receptor       727   DNA   NM_147158   SR-BP1   type I sigma receptor       728   Protein   NP_671514   SR-BP1   type I sigma receptor       729   DNA   NM_147159   SR-BP1   type I sigma receptor       730   Protein   NP_671515   SR-BP1   type I sigma receptor       731   DNA   NM_147160   SR-BP1   type I sigma receptor       732   Protein   NP_671516   SR-BP1   type I sigma receptor       733   DNA   NM_004457   FACL3   fatty-acid-Coenzyme A ligase,                       long-chain 3       734   Protein   NP_004448   FACL3   fatty-acid-Coenzyme A ligase,                       long-chain 3       735   DNA   NM_005137   DGCR2   DiGeorge syndrome critical                       region gene 2       736   Protein   NP_005128   DGCR2   DiGeorge syndrome critical                       region gene 2       737   DNA   NM_014812   KIAA0470   KIAA0470 gene product       738   Protein   NP_055627   KIAA0470   KIAA0470 gene product       739   DNA   NM_001348   DAPK3   death-associated protein kinase 3       740   Protein   NP_001339   DAPK3   death-associated protein kinase 3       741   DNA   NM_003927   MBD2   methyl-CpG binding domain                       protein 2       742   Protein   NP_003918   MBD2   methyl-CpG binding domain                       protein 2       743   DNA   NM_015832   MBD2   methyl-CpG binding domain                       protein 2       744   Protein   NP_056647   MBD2   methyl-CpG binding domain                       protein 2       745   DNA   NM_004638   BAT2   HLA-B associated transcript 2       746   Protein   NP_004629   BAT2   HLA-B associated transcript 2       747   DNA   NM_080686   BAT2   HLA-B associated transcript 2       748   Protein   NP_542417   BAT2   HLA-B associated transcript 2       749   DNA   NM_002032   FTH1   ferritin, heavy polypeptide 1       750   Protein   NP_002023   FTH1   ferritin, heavy polypeptide 1       751   DNA   NM_000477   ALB   albumin       752   Protein   NP_000468   ALB   albumin       753   DNA   NM_021019   MYL6   myosin, light polypeptide 6,                       alkali, smooth muscle and non-                       muscle       754   Protein   NP_066299   MYL6   myosin, light polypeptide 6,                       alkali, smooth muscle and non-                       muscle       755   DNA   NM_079423   MYL6   myosin, light polypeptide 6,                       alkali, smooth muscle and non-                       muscle       756   Protein   NP_524147   MYL6   myosin, light polypeptide 6,                       alkali, smooth muscle and non-                       muscle       757   DNA   NM_079424   MYL6   myosin, light polypeptide 6,                       alkali, smooth muscle and non-                       muscle       758   Protein   NP_524148   MYL6   myosin, light polypeptide 6,                       alkali, smooth muscle and non-                       muscle       759   DNA   NM_079425   MYL6   myosin, light polypeptide 6,                       alkali, smooth muscle and non-                       muscle       760   Protein   NP_524149   MYL6   myosin, light polypeptide 6,                       alkali, smooth muscle and non-                       muscle       761   DNA   AL049449         Homo sapiens  mRNA; cDNA                       DKFZp586B1722 (from clone                       DKFZp586B1722), mRNA                       sequence       762   DNA   NM_002381   MATN3   matrilin 3       763   Protein   NP_002372   MATN3   matrilin 3       764   DNA   NM_000365   TPI1   triosephosphate isomerase 1       765   Protein   NP_000356   TPI1   triosephosphate isomerase 1       766   DNA   NM_004996   ABCC1   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 1       767   Protein   NP_004987   ABCC1   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 1       768   DNA   NM_019862   ABCC1   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 1       769   Protein   NP_063915   ABCC1   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 1       770   DNA   NM_019898   ABCC1   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 1       771   Protein   NP_063953   ABCC1   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 1       772   DNA   NM_019899   ABCC1   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 1       773   Protein   NP_063954   ABCC1   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 1       774   DNA   NM_000490   AVP   arginine vasopressin                       (neurophysin II, antidiuretic                       hormone, diabetes insipidus,                       neurohypophyseal)       775   Protein   NP_000481   AVP   arginine vasopressin                       (neurophysin II, antidiuretic                       hormone, diabetes insipidus,                       neurohypophyseal)       776   DNA   NM_000999   RPL38   ribosomal protein L38       777   Protein   NP_000990   RPL38   ribosomal protein L38       778   DNA   NM_002297   LCN1   lipocalin 1 (protein migrating                       faster than albumin, tear                       prealbumin)       779   Protein   NP_002288   LCN1   lipocalin 1 (protein migrating                       faster than albumin, tear                       prealbumin)       780   DNA   NM_006068   TLR6   toll-like receptor 6       781   Protein   NP_006059   TLR6   toll-like receptor 6       782   DNA   NM_012302   LPHH1   latrophilin 1       783   Protein   NP_036434   LPHH1   latrophilin 1       784   DNA   NM_005453   ZNF297   zinc finger protein 297       785   Protein   NP_005444   ZNF297   zinc finger protein 297       786   DNA   AB020676   KIAA0869   KIAA0869 protein       787   Protein   AB020676   KIAA0869   KIAA0869 protein               (Translation)       788   DNA   D83781   NUP160   nucleoporin 160 kDa       789   Protein   D83781 (Translation)   NUP160   nucleoporin 160 kDa       790   DNA   NM_015229   KIAA0664   KIAA0664 protein       791   Protein   NP_056044   KIAA0664   KIAA0664 protein       792   DNA   NM_005873   RGS19   regulator of G-protein                       signalling 19       793   Protein   NP_005864   RGS19   regulator of G-protein                       signalling 19       794   DNA   NM_015608   DKFZp586F1019   DKFZp586F1019 protein       795   Protein   NP_056423   DKFZp586F1019   DKFZp586F1019 protein       796   DNA   NM_014892   KIAA1116   KIAA1116 protein       797   Protein   NP_055707   KIAA1116   KIAA1116 protein       798   DNA   NM_025176   KIAA0980   KIAA0980 protein       799   Protein   NP_079452   KIAA0980   KIAA0980 protein       800   DNA   NM_001217   CA11   carbonic anhydrase XI       801   Protein   NP_001208   CA11   carbonic anhydrase XI       802   DNA   NM_014323   ZNF278   zinc finger protein 278       803   Protein   NP_055138   ZNF278   zinc finger protein 278       804   DNA   NM_032050   ZNF278   zinc finger protein 278       805   Protein   NP_114439   ZNF278   zinc finger protein 278       806   DNA   NM_032051   ZNF278   zinc finger protein 278       807   Protein   NP_114440   ZNF278   zinc finger protein 278       808   DNA   NM_032052   ZNF278   zinc finger protein 278       809   Protein   NP_114441   ZNF278   zinc finger protein 278       810   DNA   NM_006196   PCBP1   poly(rC) binding protein 1       811   Protein   NP_006187   PCBP1   poly(rC) binding protein 1       812   DNA   NM_021038   MBNL   muscleblind-like ( Drosophila )       813   Protein   NP_066368   MBNL   muscleblind-like ( Drosophila )       814   DNA   NM_000485   APRT   adenine                       phosphoribosyltransferase       815   Protein   NP_000476   APRT   adenine                       phosphoribosyltransferase       816   DNA   AI040324       ESTs, Weakly similar to                       A56429 I-kappa-B-related                       protein - human [ H. sapiens ]       817   DNA   NM_006796   AFG3L2   AFG3 ATPase family gene 3-                       like 2 (yeast)       818   Protein   NP_006787   AFG3L2   AFG3 ATPase family gene 3-                       like 2 (yeast)       819   DNA   NM_014876   KIAA0063   KIAA0063 gene product       820   Protein   NP_055691   KIAA0063   KIAA0063 gene product       821   DNA   NM_007358   M96   likely ortholog of mouse metal                       response element binding                       transcription factor 2       822   Protein   NP_031384   M96   likely ortholog of mouse metal                       response element binding                       transcription factor 2       823   DNA   NM_002956   RSN   restin (Reed-Steinberg cell-                       expressed intermediate                       filament-associated protein)       824   Protein   NP_002947   RSN   restin (Reed-Steinberg cell-                       expressed intermediate                       filament-associated protein)       825   DNA   NM_000281   PCBD   6-pyruvoyl-tetrahydropterin                       synthase/dimerization cofactor                       of hepatocyte nuclear factor 1                       alpha (TCF1)       826   Protein   NP_000272   PCBD   6-pyruvoyl-tetrahydropterin                       synthase/dimerization cofactor                       of hepatocyte nuclear factor 1                       alpha (TCF1)       827   DNA   NM_015200   KIAA0648   KIAA0648 protein       828   Protein   NP_056015   KIAA0648   KIAA0648 protein       829   DNA   NM_004992   MECP2   methyl CpG binding protein 2                       (Rett syndrome)       830   Protein   NP_004983   MECP2   methyl CpG binding protein 2                       (Rett syndrome)       831   DNA   NM_021134   MRPL23   mitochondrial ribosomal                       protein L23       832   Protein   NP_066957   MRPL23   mitochondrial ribosomal                       protein L23       833   DNA   NM_005134   PPP4R1   protein phosphatase 4,                       regulatory subunit 1       834   Protein   NP_005125   PPP4R1   protein phosphatase 4,                       regulatory subunit 1       835   DNA   NM_001122   ADFP   adipose differentiation-related                       protein       836   Protein   NP_001113   ADFP   adipose differentiation-related                       protein       837   DNA   NM_003368   USP1   ubiquitin specific protease 1       838   Protein   NP_003359   USP1   ubiquitin specific protease 1       839   DNA   NM_003925   MBD4   methyl-CpG binding domain                       protein 4       840   Protein   NP_003916   MBD4   methyl-CpG binding domain                       protein 4       841   DNA   NM_015339   ADNP   activity-dependent                       neuroprotector       842   Protein   NP_056154   ADNP   activity-dependent                       neuroprotector       843   DNA   NM_015338   KIAA0978   KIAA0978 protein       844   Protein   NP_056153   KIAA0978   KIAA0978 protein       845   DNA   NM_006107   OA48-18   acid-inducible phosphoprotein       846   Protein   NP_006098   OA48-18   acid-inducible phosphoprotein       847   DNA   NM_014402   QP-C   low molecular mass                       ubiquinone-binding protein                       (9.5 kD)       848   Protein   NP_055217   QP-C   low molecular mass                       ubiquinone-binding protein                       (9.5 kD)       849   DNA   NM_005928   MFGE8   milk fat globule-EGF factor 8                       protein       850   Protein   NP_005919   MFGE8   milk fat globule-EGF factor 8                       protein       851   DNA   NM_003356   UCP3   uncoupling protein 3                       (mitochondrial, proton carrier)       852   Protein   NP_003347   UCP3   uncoupling protein 3                       (mitochondrial, proton carrier)       853   DNA   NM_022803   UCP3   uncoupling protein 3                       (mitochondrial, proton carrier)       854   Protein   NP_073714   UCP3   uncoupling protein 3                       (mitochondrial, proton carrier)       855   DNA   R61362       Unknown protein [ Homo                           sapiens ], mRNA sequence       856   DNA   NM_003176   SYCP1   synaptonemal complex protein 1       857   Protein   NP_003167   SYCP1   synaptonemal complex protein 1       858   DNA   NM_005680   TAF1B   TATA box binding protein                       (TBP)-associated factor, RNA                       polymerase I, B, 63 kDa       859   Protein   NP_005671   TAF1B   TATA box binding protein                       (TBP)-associated factor, RNA                       polymerase I, B, 63 kDa       860   DNA   NM_030928   CDT1   DNA replication factor       861   Protein   NP_112190   CDT1   DNA replication factor       862   DNA   AF052108         Homo sapiens  clone 23687                       mRNA sequence       863   DNA   NM_021012   KCNJ12   potassium inwardly-rectifying                       channel, subfamily J, member                       12       864   Protein   NP_066292   KCNJ12   potassium inwardly-rectifying                       channel, subfamily J, member                       12       865   DNA   NM_014875   KIF14   kinesin family member 14       866   Protein   NP_055690   KIF14   kinesin family member 14       867   DNA   NM_002954   RPS27A   ribosomal protein S27a       868   Protein   NP_002945   RPS27A   ribosomal protein S27a       869   DNA   NM_001021   RPS17   ribosomal protein S17       870   Protein   NP_001012   RPS17   ribosomal protein S17       871   DNA   NM_004983   KCNJ9   potassium inwardly-rectifying                       channel, subfamily J, member 9       872   Protein   NP_004974   KCNJ9   potassium inwardly-rectifying                       channel, subfamily J, member 9       873   DNA   NM_001926   DEFA6   defensin, alpha 6, Paneth cell-                       specific       874   Protein   NP_001917   DEFA6   defensin, alpha 6, Paneth cell-                       specific       875   DNA   NM_001005   RPS3   ribosomal protein S3       876   Protein   NP_000996   RPS3   ribosomal protein S3       877   DNA   NM_001011   RPS7   ribosomal protein S7       878   Protein   NP_001002   RPS7   ribosomal protein S7       879   DNA   NM_004396   DDX5   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 5                       (RNA helicase, 68 kDa)       880   Protein   NP_004387   DDX5   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 5                       (RNA helicase, 68 kDa)       881   DNA   NM_145809   LOC220594   TL132 protein       882   Protein   NP_665808   LOC220594   TL132 protein       883   DNA   NM_005718   ARPC4   actin related protein 2/3                       complex, subunit 4, 20 kDa       884   Protein   NP_005709   ARPC4   actin related protein 2/3                       complex, subunit 4, 20 kDa       885   DNA   NM_002336   LRP6   low density lipoprotein                       receptor-related protein 6       886   Protein   NP_002327   LRP6   low density lipoprotein                       receptor-related protein 6       887   DNA   NM_012120   CD2AP   CD2-associated protein       888   Protein   NP_036252   CD2AP   CD2-associated protein       889   DNA   AB011090   MGA   MAX gene associated       890   Protein   AB011090   MGA   MAX gene associated               (Translation)       891   DNA   NM_000875   IGF1R   insulin-like growth factor 1                       receptor       892   Protein   NP_000866   IGF1R   insulin-like growth factor 1                       receptor       893   DNA   U44385       Cluster Incl. U44385: Human                       tissue inhibitor of                       metalloproteinases-2 (TIMP-2)                       gene /cds = (302.958)                       /gb = U44385 /gi = 1517892                       /ug = Hs.239409 /len = 1069       894   Protein   U44385 (Translation)       Cluster Incl. U44385: Human                       tissue inhibitor of                       metalloproteinases-2 (TIMP-2)                       gene /cds = (302.958)                       /gb = U44385 /gi = 1517892                       /ug = Hs.239409 /len = 1069       895   DNA   NM_004491   GRLF1   glucocorticoid receptor DNA                       binding factor 1       896   Protein   NP_004482   GRLF1   glucocorticoid receptor DNA                       binding factor 1       897   DNA   NM_024342   GRLF1   glucocorticoid receptor DNA                       binding factor 1       898   Protein   NP_077318   GRLF1   glucocorticoid receptor DNA                       binding factor 1       899   DNA   NM_017737   FLJ20275   hypothetical protein FLJ20275       900   Protein   NP_060207   FLJ20275   hypothetical protein FLJ20275       901   DNA   NM_005484   ADPRTL2   ADP-ribosyltransferase                       (NAD+; poly(ADP-ribose)                       polymerase)-like 2       902   Protein   NP_005475   ADPRTL2   ADP-ribosyltransferase                       (NAD+; poly(ADP-ribose)                       polymerase)-like 2       903   DNA   NM_005445   CSPG6   chondroitin sulfate                       proteoglycan 6 (bamacan)       904   Protein   NP_005436   CSPG6   chondroitin sulfate                       proteoglycan 6 (bamacan)       905   DNA   NM_012121   CDC42EP4   CDC42 effector protein (Rho                       GTPase binding) 4       906   Protein   NP_036253   CDC42EP4   CDC42 effector protein (Rho                       GTPase binding) 4       907   DNA   AB028948   KIAA1025   KIAA1025 protein       908   Protein   AB028948   KIAA1025   KIAA1025 protein               (Translation)       909   DNA   NM_018433   TSGA   zinc finger protein       910   Protein   NP_060903   TSGA   zinc finger protein       911   DNA   D14678   KNSL2   kinesin-like 2       912   Protein   D14678 (Translation)   KNSL2   kinesin-like 2       913   DNA   AF022789   USP12   ubiquitin specific protease 12       914   Protein   AF022789   USP12   ubiquitin specific protease 12               (Translation)       915   DNA   NM_018155   FLJ10618   hypothetical protein FLJ10618       916   Protein   NP_060625   FLJ10618   hypothetical protein FLJ10618       917   DNA   AB023216       KIAA0999 protein [ Homo                           sapiens ], mRNA sequence       918   Protein   AB023216       KIAA0999 protein [ Homo                 (Translation)         sapiens ], mRNA sequence       919   DNA   NM_004454   ETV5   ets variant gene 5 (ets-related                       molecule)       920   Protein   NP_004445   ETV5   ets variant gene 5 (ets-related                       molecule)       921   DNA   NM_016614   TTRAP   TRAF and TNF receptor-                       associated protein       922   Protein   NP_057698   TTRAP   TRAF and TNF receptor-                       associated protein       923   DNA   AB002374   KIAA0376   KIAA0376 protein       924   Protein   AB002374   KIAA0376   KIAA0376 protein               (Translation)       925   DNA   NM_014889   PITRM1   pitrilysin metalloproteinase 1       926   Protein   NP_055704   PITRM1   pitrilysin metalloproteinase 1       927   DNA   NM_014968   PITRM1   pitrilysin metalloproteinase 1       928   Protein   NP_055783   PITRM1   pitrilysin metalloproteinase 1       929   DNA   NM_014643   KIAA0222   KIAA0222 gene product       930   Protein   NP_055458   KIAA0222   KIAA0222 gene product       931   DNA   NM_003158   STK6   serine/threonine kinase 6       932   Protein   NP_003149   STK6   serine/threonine kinase 6       933   DNA   NM_003600   STK6   serine/threonine kinase 6       934   Protein   NP_003591   STK6   serine/threonine kinase 6       935   DNA   NM_006392   NOL5A   nucleolar protein 5A (56 kDa                       with KKE/D repeat)       936   Protein   NP_006383   NOL5A   nucleolar protein 5A (56 kDa                       with KKE/D repeat)       937   DNA   NM_021074   NDUFV2   NADH dehydrogenase                       (ubiquinone) flavoprotein 2,                       24 kDa       938   Protein   NP_066552   NDUFV2   NADH dehydrogenase                       (ubiquinone) flavoprotein 2,                       24 kDa       939   DNA   U51704   KIAA1971   similar to junction-mediating                       and regulatory protein p300                       JMY       940   DNA   AI655458   OPLAH   5-oxoprolinase (ATP-                       hydrolysing)       941   DNA   NM_002136   HNRPA1   heterogeneous nuclear                       ribonucleoprotein A1       942   Protein   NP_002127   HNRPA1   heterogeneous nuclear                       ribonucleoprotein A1       943   DNA   NM_031157   HNRPA1   heterogeneous nuclear                       ribonucleoprotein A1       944   Protein   NP_112420   HNRPA1   heterogeneous nuclear                       ribonucleoprotein A1       945   DNA   NM_000337   SGCD   sarcoglycan, delta (35 kDa                       dystrophin-associated                       glycoprotein)       946   Protein   NP_000328   SGCD   sarcoglycan, delta (35 kDa                       dystrophin-associated                       glycoprotein)       947   DNA   NM_172244   SGCD   sarcoglycan, delta (35 kDa                       dystrophin-associated                       glycoprotein)       948   Protein   NP_758447   SGCD   sarcoglycan, delta (35 kDa                       dystrophin-associated                       glycoprotein)       949   DNA   NM_004876   ZNF254   zinc finger protein 254       950   Protein   NP_004867   ZNF254   zinc finger protein 254       951   DNA   D87466   KIAA0276   KIAA0276 protein       952   Protein   D87466 (Translation)   KIAA0276   KIAA0276 protein       953   DNA   NM_000828   GRIA3   glutamate receptor, ionotrophic,                       AMPA 3       954   Protein   NP_000819   GRIA3   glutamate receptor, ionotrophic,                       AMPA 3       955   DNA   NM_007325   GRIA3   glutamate receptor, ionotrophic,                       AMPA 3       956   Protein   NP_015564   GRIA3   glutamate receptor, ionotrophic,                       AMPA 3       957   DNA   NM_001207   BTF3   basic transcription factor 3       958   Protein   NP_001198   BTF3   basic transcription factor 3       959   DNA   NM_152260   C18B11   C18B11 homolog (44.9 kD)       960   Protein   NP_689473   C18B11   C18B11 homolog (44.9 kD)       961   DNA   NM_000146   FTL   ferritin, light polypeptide       962   Protein   NP_000137   FTL   ferritin, light polypeptide       963   DNA   W27417   HSMPP8   M-phase phosphoprotein, mpp8       964   DNA   NM_012423   RPL13A   ribosomal protein L13a       965   Protein   NP_036555   RPL13A   ribosomal protein L13a       966   DNA   NM_005858   AKAP8   A kinase (PRKA) anchor                       protein 8       967   Protein   NP_005849   AKAP8   A kinase (PRKA) anchor                       protein 8       968   DNA   R59697         Homo sapiens  mRNA                       fragment, mRNA sequence       969   DNA   NM_002485   NBS1   Nijmegen breakage syndrome 1                       (nibrin)       970   Protein   NP_002476   NBS1   Nijmegen breakage syndrome 1                       (nibrin)       971   DNA   NM_003893   LDB1   LIM domain binding 1       972   Protein   NP_003884   LDB1   LIM domain binding 1       973   DNA   NM_014947   KIAA1041   KIAA1041 protein       974   Protein   NP_055762   KIAA1041   KIAA1041 protein       975   DNA   NM_006052   DSCR3   Down syndrome critical region                       gene 3       976   Protein   NP_006043   DSCR3   Down syndrome critical region                       gene 3       977   DNA   NM_138350   LOC90326     Homo sapiens  hypothetical                       protein MGC33488       978   Protein   NP_612359   LOC90326     Homo sapiens  hypothetical                       protein MGC33488       979   DNA   NM_012330   MORF   monocytic leukemia zinc finger                       protein-related factor       980   Protein   NP_036462   MORF   monocytic leukemia zinc finger                       protein-related factor       981   DNA   NM_007218   TRC8   patched related protein                       translocated in renal cancer       982   Protein   NP_009149   TRC8   patched related protein                       translocated in renal cancer       983   DNA   NM_003135   SRP19   signal recognition particle                       19 kDa       984   Protein   NP_003126   SRP19   signal recognition particle                       19 kDa       985   DNA   AA535884   PCTK3   PCTAIRE protein kinase 3       986   DNA   NM_004860   FXR2   fragile X mental retardation,                       autosomal homolog 2       987   Protein   NP_004851   FXR2   fragile X mental retardation,                       autosomal homolog 2       988   DNA   NM_006698   BLCAP   bladder cancer associated                       protein       989   Protein   NP_006689   BLCAP   bladder cancer associated                       protein       990   DNA   NM_022826   AXOT   axotrophin       991   Protein   NP_073737   AXOT   axotrophin       992   DNA   NM_004597   SNRPD2   small nuclear ribonucleoprotein                       D2 polypeptide 16.5 kDa       993   Protein   NP_004588   SNRPD2   small nuclear ribonucleoprotein                       D2 polypeptide 16.5 kDa       994   DNA   NM_001032       Cluster Incl.                       AI541542: libtest16.A02.r                         Homo sapiens  cDNA, 5′ end                       /clone_end = 5′ /gb = AI541542                       /gi = 4458915 /ug = Hs.539                       /len = 639       995   Protein   NP_001023       Cluster Incl.                       AI541542: libtest16.A02.r                         Homo sapiens  cDNA, 5′ end                       /clone_end = 5′ /gb = AI541542                       /gi = 4458915 /ug = Hs.539                       /len = 639       996   DNA   NM_004356   CD81   CD81 antigen (target of                       antiproliferative antibody 1)       997   Protein   NP_004347   CD81   CD81 antigen (target of                       antiproliferative antibody 1)       998   DNA   NM_152758   FLJ31657   hypothetical protein FLJ31657       999   Protein   NP_689971   FLJ31657   hypothetical protein FLJ31657       1000   DNA   NM_012399   PITPNB   phosphotidylinositol transfer                       protein, beta       1001   Protein   NP_036531   PITPNB   phosphotidylinositol transfer                       protein, beta       1002   DNA   AL049941         Homo sapiens  mRNA; cDNA                       DKFZp564E2222 (from clone                       DKFZp564E2222), mRNA                       sequence       1003   DNA   NM_006362   NXF1   nuclear RNA export factor 1       1004   Protein   NP_006353   NXF1   nuclear RNA export factor 1       1005   DNA   NM_001358   DDX15   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 15       1006   Protein   NP_001349   DDX15   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 15       1007   DNA   NM_006570   RAGA   Ras-related GTP-binding                       protein       1008   Protein   NP_006561   RAGA   Ras-related GTP-binding                       protein       1009   DNA   NM_006565   CTCF   CCCTC-binding factor (zinc                       finger protein)       1010   Protein   NP_006556   CTCF   CCCTC-binding factor (zinc                       finger protein)       1011   DNA   NM_006852   TLK2   tousled-like kinase 2       1012   Protein   NP_006843   TLK2   tousled-like kinase 2       1013   DNA   NM_012289   KEAP1   Kelch-like ECH-associated                       protein 1       1014   Protein   NP_036421   KEAP1   Kelch-like ECH-associated                       protein 1       1015   DNA   NM_016322   RAB14   RAB14, member RAS                       oncogene family       1016   Protein   NP_057406   RAB14   RAB14, member RAS                       oncogene family       1017   DNA   NM_003756   EIF3S3   eukaryotic translation initiation                       factor 3, subunit 3 gamma,                       40 kDa       1018   Protein   NP_003747   EIF3S3   eukaryotic translation initiation                       factor 3, subunit 3 gamma,                       40 kDa       1019   DNA   NM_002569   FURIN   furin (paired basic amino acid                       cleaving enzyme)       1020   Protein   NP_002560   FURIN   furin (paired basic amino acid                       cleaving enzyme)       1021   DNA   NM_014862   ARNT2   aryl-hydrocarbon receptor                       nuclear translocator 2       1022   Protein   NP_055677   ARNT2   aryl-hydrocarbon receptor                       nuclear translocator 2       1023   DNA   NM_014966   DDX30   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 30       1024   Protein   NP_055781   DDX30   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 30       1025   DNA   NM_138614   DDX30   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 30       1026   Protein   NP_619519   DDX30   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 30       1027   DNA   NM_138615   DDX30   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 30       1028   Protein   NP_619520   DDX30   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 30       1029   DNA   NM_152301   MGC9651   hypothetical protein MGC9651       1030   Protein   NP_689514   MGC9651   hypothetical protein MGC9651       1031   DNA   NM_015317   PUM2   pumilio homolog 2                       ( Drosophila )       1032   Protein   NP_056132   PUM2   pumilio homolog 2                       ( Drosophila )       1033   DNA   NM_003457   ZNF207   zinc finger protein 207       1034   Protein   NP_003448   ZNF207   zinc finger protein 207       1035   DNA   M61906   PIK3R1   phosphoinositide-3-kinase,                       regulatory subunit, polypeptide                       1 (p85 alpha)       1036   DNA   NM_015649   DKFZP434M154   DKFZP434M154 protein       1037   Protein   NP_056464   DKFZP434M154   DKFZP434M154 protein       1038   DNA   NM_004194   ADAM22   a disintegrin and                       metalloproteinase domain 22       1039   Protein   NP_004185   ADAM22   a disintegrin and                       metalloproteinase domain 22       1040   DNA   NM_016351   ADAM22   a disintegrin and                       metalloproteinase domain 22       1041   Protein   NP_057435   ADAM22   a disintegrin and                       metalloproteinase domain 22       1042   DNA   NM_021721   ADAM22   a disintegrin and                       metalloproteinase domain 22       1043   Protein   NP_068367   ADAM22   a disintegrin and                       metalloproteinase domain 22       1044   DNA   NM_005466   MED6   mediator of RNA polymerase II                       transcription, subunit 6                       homolog (yeast)       1045   Protein   NP_005457   MED6   mediator of RNA polymerase II                       transcription, subunit 6                       homolog (yeast)       1046   DNA   NM_004486   GOLGA2   golgi autoantigen, golgin                       subfamily a, 2       1047   Protein   NP_004477   GOLGA2   golgi autoantigen, golgin                       subfamily a, 2       1048   DNA   NM_021047   ZNF253   zinc finger protein 253       1049   Protein   NP_066385   ZNF253   zinc finger protein 253       1050   DNA   NM_017523   HSXIAPAF1   XIAP associated factor-1       1051   Protein   NP_059993   HSXIAPAF1   XIAP associated factor-1       1052   DNA   NM_014010   ASTN2   astrotactin 2       1053   Protein   NP_054729   ASTN2   astrotactin 2       1054   DNA   NM_006114   TOMM40   translocase of outer                       mitochondrial membrane 40                       homolog (yeast)       1055   Protein   NP_006105   TOMM40   translocase of outer                       mitochondrial membrane 40                       homolog (yeast)       1056   DNA   NM_006556   PMVK   phosphomevalonate kinase       1057   Protein   NP_006547   PMVK   phosphomevalonate kinase       1058   DNA   NM_020831   MKL1   megakaryoblastic leukemia                       (translocation) 1       1059   Protein   NP_065882   MKL1   megakaryoblastic leukemia                       (translocation) 1       1060   DNA   NM_003172   SURF1   surfeit 1       1061   Protein   NP_003163   SURF1   surfeit 1       1062   DNA   NM_005922   MAP3K4   mitogen-activated protein                       kinase kinase kinase 4       1063   Protein   NP_005913   MAP3K4   mitogen-activated protein                       kinase kinase kinase 4       1064   DNA   NM_006724   MAP3K4   mitogen-activated protein                       kinase kinase kinase 4       1065   Protein   NP_006715   MAP3K4   mitogen-activated protein                       kinase kinase kinase 4       1066   DNA   NM_015446   ELYS   ELYS transcription factor-like                       protein TMBS62       1067   Protein   NP_056261   ELYS   ELYS transcription factor-like                       protein TMBS62       1068   DNA   NM_002589   PCDH7   BH-protocadherin (brain-heart)       1069   Protein   NP_002580   PCDH7   BH-protocadherin (brain-heart)       1070   DNA   NM_032456   PCDH7   BH-protocadherin (brain-heart)       1071   Protein   NP_115832   PCDH7   BH-protocadherin (brain-heart)       1072   DNA   NM_032457   PCDH7   BH-protocadherin (brain-heart)       1073   Protein   NP_115833   PCDH7   BH-protocadherin (brain-heart)       1074   DNA   NM_020119   ZAP   zinc finger antiviral protein       1075   Protein   NP_064504   ZAP   zinc finger antiviral protein       1076   DNA   NM_024625   ZAP   zinc finger antiviral protein       1077   Protein   NP_078901   ZAP   zinc finger antiviral protein       1078   DNA   NM_001211   BUB1B   BUB1 budding uninhibited by                       benzimidazoles 1 homolog beta                       (yeast)       1079   Protein   NP_001202   BUB1B   BUB1 budding uninhibited by                       benzimidazoles 1 homolog beta                       (yeast)       1080   DNA   NM_014042   DKFZP564M082   DKFZP564M082 protein       1081   Protein   NP_054761   DKFZP564M082   DKFZP564M082 protein       1082   DNA   AB011178   SCOP   SCN Circadian Oscillatory                       Protein (SCOP)       1083   Protein   AB011178   SCOP   SCN Circadian Oscillatory               (Translation)       Protein (SCOP)       1084   DNA   NM_015542   RENT2   regulator of nonsense                       transcripts 2       1085   Protein   NP_056357   RENT2   regulator of nonsense                       transcripts 2       1086   DNA   NM_080599   RENT2   regulator of nonsense                       transcripts 2       1087   DNA   NM_005722   ACTR2   ARP2 actin-related protein 2                       homolog (yeast)       1088   Protein   NP_005713   ACTR2   ARP2 actin-related protein 2                       homolog (yeast)       1089   DNA   NM_021090   MTMR3   myotubularin related protein 3       1090   Protein   NP_066576   MTMR3   myotubularin related protein 3       1091   DNA   NM_153050   MTMR3   myotubularin related protein 3       1092   Protein   NP_694690   MTMR3   myotubularin related protein 3       1093   DNA   NM_153051   MTMR3   myotubularin related protein 3       1094   Protein   NP_694691   MTMR3   myotubularin related protein 3       1095   DNA   NM_003559   PIP5K2B   phosphatidylinositol-4-                       phosphate 5-kinase, type II,                       beta       1096   Protein   NP_003550   PIP5K2B   phosphatidylinositol-4-                       phosphate 5-kinase, type II,                       beta       1097   DNA   NM_138687   PIP5K2B   phosphatidylinositol-4-                       phosphate 5-kinase, type II,                       beta       1098   Protein   NP_619632   PIP5K2B   phosphatidylinositol-4-                       phosphate 5-kinase, type II,                       beta       1099   DNA   NM_006356   ATP5H   ATP synthase, H+ transporting,                       mitochondrial F0 complex,                       subunit d       1100   Protein   NP_006347   ATP5H   ATP synthase, H+ transporting,                       mitochondrial F0 complex,                       subunit d       1101   DNA   NM_015176   KIAA0483   KIAA0483 protein       1102   Protein   NP_055991   KIAA0483   KIAA0483 protein       1103   DNA   NM_003611   OFD1   oral-facial-digital syndrome 1       1104   Protein   NP_003602   OFD1   oral-facial-digital syndrome 1       1105   DNA   NM_002938   RNF4   ring finger protein 4       1106   Protein   NP_002929   RNF4   ring finger protein 4       1107   DNA   NM_015310   EFA6R   ADP-ribosylation factor                       guanine nucleotide factor 6       1108   Protein   NP_056125   EFA6R   ADP-ribosylation factor                       guanine nucleotide factor 6       1109   DNA   NM_015530   GORASP2   golgi reassembly stacking                       protein 2, 55 kDa       1110   Protein   NP_056345   GORASP2   golgi reassembly stacking                       protein 2, 55 kDa       1111   DNA   NM_006275     Homo sapiens       Homo sapiens  mRNA; cDNA                   splicing factor,   DKFZp564J223 (from clone                   arginine/serine-   DKFZp564J223), mRNA                   rich 6   sequence                   (SFRS6),                   mRNA       1112   Protein   NP_006266     Homo sapiens       Homo sapiens  mRNA; cDNA                   splicing factor,   DKFZp564J223 (from clone                   arginine/serine-   DKFZp564J223), mRNA                   rich 6   sequence                   (SFRS6)       1113   DNA   NM_012470   TRN-SR   transportin-SR       1114   Protein   NP_036602   TRN-SR   transportin-SR       1115   DNA   NM_006360   GA17   dendritic cell protein       1116   Protein   NP_006351   GA17   dendritic cell protein       1117   DNA   NM_014159   HIF1   huntingtin interacting protein 1       1118   Protein   NP_054878   HIF1   huntingtin interacting protein 1       1119   DNA   NM_000100   CSTB   cystatin B (stefin B)       1120   Protein   NP_000091   CSTB   cystatin B (stefin B)       1121   DNA   NM_018947   CYCS   cytochrome c, somatic       1122   Protein   NP_061820   CYCS   cytochrome c, somatic       1123   DNA   NM_001312   CRIP2   cysteine-rich protein 2       1124   Protein   NP_001303   CRIP2   cysteine-rich protein 2       1125   DNA   AB002368   RANBP20   RAN binding protein 20       1126   Protein   AB002368   RANBP20   RAN binding protein 20               (Translation)       1127   DNA   NM_021188   APA1   likely ortholog of mouse                       another partner for ARF 1       1128   Protein   NP_067011   APA1   likely ortholog of mouse                       another partner for ARF 1       1129   DNA   NM_003129   SQLE   squalene epoxidase       1130   Protein   NP_003120   SQLE   squalene epoxidase       1131   DNA   NM_020357   PCNP   PEST-containing nuclear                       protein       1132   Protein   NP_065090   PCNP   PEST-containing nuclear                       protein       1133   DNA   NM_006323   SEC24B   SEC24 related gene family,                       member B ( S. cerevisiae )       1134   Protein   NP_006314   SEC24B   SEC24 related gene family,                       member B ( S. cerevisiae )       1135   DNA   AB028980   USP24   ubiquitin specific protease 24       1136   Protein   AB028980   USP24   ubiquitin specific protease 24               (Translation)       1137   DNA   AL049432   RAI17   retinoic acid induced 17       1138   DNA   NM_015167   PTDSR   phosphatidylserine receptor       1139   Protein   NP_055982   PTDSR   phosphatidylserine receptor       1140   DNA   NM_000753   PDE3B   phosphodiesterase 3B, cGMP-                       inhibited       1141   Protein   NP_000744   PDE3B   phosphodiesterase 3B, cGMP-                       inhibited       1142   DNA   NM_000922   PDE3B   phosphodiesterase 3B, cGMP-                       inhibited       1143   Protein   NP_000913   PDE3B   phosphodiesterase 3B, cGMP-                       inhibited       1144   DNA   NM_005224   DRIL1   dead ringer-like 1 ( Drosophila )       1145   Protein   NP_005215   DRIL1   dead ringer-like 1 ( Drosophila )       1146   DNA   NM_002155   HSPA6   heat shock 70 kDa protein 6                       (HSP70B′)       1147   Protein   NP_002146   HSPA6   heat shock 70 kDa protein 6                       (HSP70B′)       1148   DNA   NM_012242   DKK1   dickkopf homolog 1 ( Xenopus                           laevis )       1149   Protein   NP_036374   DKK1   dickkopf homolog 1 ( Xenopus                           laevis )       1150   DNA   NM_004715   CTDP1   CTD (carboxy-terminal                       domain, RNA polymerase II,                       polypeptide A) phosphatase,                       subunit 1       1151   Protein   NP_004706   CTDP1   CTD (carboxy-terminal                       domain, RNA polymerase II,                       polypeptide A) phosphatase,                       subunit 1       1152   DNA   NM_048368   CTDP1   CTD (carboxy-terminal                       domain, RNA polymerase II,                       polypeptide A) phosphatase,                       subunit 1       1153   Protein   NP_430255   CTDP1   CTD (carboxy-terminal                       domain, RNA polymerase II,                       polypeptide A) phosphatase,                       subunit 1       1154   DNA   NM_001952   E2F6   E2F transcription factor 6       1155   Protein   NP_001943   E2F6   E2F transcription factor 6       1156   DNA   NM_014939   KIAA1012   KIAA1012 protein       1157   Protein   NP_055754   KIAA1012   KIAA1012 protein       1158   DNA   NM_006250   PRH1   proline-rich protein HaeIII                       subfamily 1       1159   Protein   NP_006241   PRH1   proline-rich protein HaeIII                       subfamily 1       1160   DNA   NM_021974   POLR2F   polymerase (RNA) II (DNA                       directed) polypeptide F       1161   Protein   NP_068809   POLR2F   polymerase (RNA) II (DNA                       directed) polypeptide F       1162   DNA   NM_001584   C11orf8   chromosome 11 open reading                       frame 8       1163   Protein   NP_001575   C11orf8   chromosome 11 open reading                       frame 8       1164   DNA   NM_015438   DKFZP586I2223   intermediate filament-like                       MGC: 2625       1165   Protein   NP_056253   DKFZP586I2223   intermediate filament-like                       MGC: 2625       1166   DNA   NM_080730   DKFZP586I2223   intermediate filament-like                       MGC: 2625       1167   Protein   NP_542768   DKFZP586I2223   intermediate filament-like                       MGC: 2625       1168   DNA   NM_080731   DKFZP586I2223   intermediate filament-like                       MGC: 2625       1169   Protein   NP_542769   DKFZP586I2223   intermediate filament-like                       MGC: 2625       1170   DNA   NM_003801   GPAA1   GPAA1P anchor attachment                       protein 1 homolog (yeast)       1171   Protein   NP_003792   GPAA1   GPAA1P anchor attachment                       protein 1 homolog (yeast)       1172   DNA   NM_000347   SPTB   spectrin, beta, erythrocytic                       (includes spherocytosis, clinical                       type I)       1173   Protein   NP_000338   SPTB   spectrin, beta, erythrocytic                       (includes spherocytosis, clinical                       type I)       1174   DNA   NM_003686   EXO1   exonuclease 1       1175   Protein   NP_003677   EXO1   exonuclease 1       1176   DNA   NM_006027   EXO1   exonuclease 1       1177   Protein   NP_006018   EXO1   exonuclease 1       1178   DNA   NM_130398   EXO1   exonuclease 1       1179   Protein   NP_569082   EXO1   exonuclease 1       1180   DNA   NM_014345   ZFP318   endocrine regulator       1181   Protein   NP_055160   ZFP318   endocrine regulator       1182   DNA   NM_001262   CDKN2C   cyclin-dependent kinase                       inhibitor 2C (p18, inhibits                       CDK4)       1183   Protein   NP_001253   CDKN2C   cyclin-dependent kinase                       inhibitor 2C (p18, inhibits                       CDK4)       1184   DNA   NM_078626   CDKN2C   cyclin-dependent kinase                       inhibitor 2C (p18, inhibits                       CDK4)       1185   DNA   AB020699   KIAA0892   KIAA0892 protein       1186   Protein   AB020699   KIAA0892   KIAA0892 protein               (Translation)       1187   DNA   AB007925   FNBP2   formin binding protein 2       1188   Protein   AB007925   FNBP2   formin binding protein 2               (Translation)       1189   DNA   NM_004898   CLOCK   clock homolog (mouse)       1190   Protein   NP_004889   CLOCK   clock homolog (mouse)       1191   DNA   NM_003720   DSCR2   Down syndrome critical region                       gene 2       1192   Protein   NP_003711   DSCR2   Down syndrome critical region                       gene 2       1193   DNA   NM_006924   SFRS1   splicing factor, arginine/serine-                       rich 1 (splicing factor 2,                       alternate splicing factor)       1194   Protein   NP_008855   SFRS1   splicing factor, arginine/serine-                       rich 1 (splicing factor 2,                       alternate splicing factor)       1195   DNA   NM_004326   BCL9   B-cell CLL/lymphoma 9       1196   Protein   NP_004317   BCL9   B-cell CLL/lymphoma 9       1197   DNA   NM_003283   TNNT1   troponin T1, skeletal, slow       1198   Protein   NP_003274   TNNT1   troponin T1, skeletal, slow       1199   DNA   NM_021126   MPST   mercaptopyruvate                       sulfurtransferase       1200   Protein   NP_066949   MPST   mercaptopyruvate                       sulfurtransferase       1201   DNA   NM_001182   ALDH7A1   aldehyde dehydrogenase 7                       family, member A1       1202   Protein   NP_001173   ALDH7A1   aldehyde dehydrogenase 7                       family, member A1       1203   DNA   NM_001749   CAPNS1   calpain, small subunit 1       1204   Protein   NP_001740   CAPNS1   calpain, small subunit 1       1205   DNA   NM_004346   CASP3   caspase 3, apoptosis-related                       cysteine protease       1206   Protein   NP_004337   CASP3   caspase 3, apoptosis-related                       cysteine protease       1207   DNA   NM_032991   CASP3   caspase 3, apoptosis-related                       cysteine protease       1208   DNA   NM_003145   SSR2   signal sequence receptor, beta                       (translocon-associated protein                       beta)       1209   Protein   NP_003136   SSR2   signal sequence receptor, beta                       (translocon-associated protein                       beta)       1210   DNA   NM_153273   IHPK1   inositol hexaphosphate kinase 1       1211   Protein   NP_695005   IHPK1   inositol hexaphosphate kinase 1       1212   DNA   NM_001728   BSG   basigin (OK blood group)       1213   Protein   NP_001719   BSG   basigin (OK blood group)       1214   DNA   NM_004374   COX6C   cytochrome c oxidase subunit                       VIc       1215   Protein   NP_004365   COX6C   cytochrome c oxidase subunit                       VIc       1216   DNA   NM_004047   ATP6V0B   ATPase, H+ transporting,                       lysosomal 21 kDa, V0 subunit                       c″       1217   Protein   NP_004038   ATP6V0B   ATPase, H+ transporting,                       lysosomal 21 kDa, V0 subunit                       c″       1218   DNA   NM_004541   NDUFA1   NADH dehydrogenase                       (ubiquinone) 1 alpha                       subcomplex, 1, 7.5 kDa       1219   Protein   NP_004532   NDUFA1   NADH dehydrogenase                       (ubiquinone) 1 alpha                       subcomplex, 1, 7.5 kDa       1220   DNA   NM_014297   YF13H12   protein expressed in thyroid       1221   Protein   NP_055112   YF13H12   protein expressed in thyroid       1222   DNA   NM_004759   MAPKAPK2   mitogen-activated protein                       kinase-activated protein kinase 2       1223   Protein   NP_004750   MAPKAPK2   mitogen-activated protein                       kinase-activated protein kinase 2       1224   DNA   NM_032960   MAPKAPK2   mitogen-activated protein                       kinase-activated protein kinase 2       1225   Protein   NP_116584   MAPKAPK2   mitogen-activated protein                       kinase-activated protein kinase 2       1226   DNA   NM_000289   PFKM   phosphofructokinase, muscle       1227   Protein   NP_000280   PFKM   phosphofructokinase, muscle       1228   DNA   NM_005104   BRD2   bromodomain containing 2       1229   Protein   NP_005095   BRD2   bromodomain containing 2       1230   DNA   NM_004235   KLF4   Kruppel-like factor 4 (gut)       1231   Protein   NP_004226   KLF4   Kruppel-like factor 4 (gut)       1232   DNA   NM_007271   STK38   serine/threonine kinase 38       1233   Protein   NP_009202   STK38   serine/threonine kinase 38       1234   DNA   NM_138448   ACYP2   acylphosphatase 2, muscle type       1235   Protein   NP_612457   ACYP2   acylphosphatase 2, muscle type       1236   DNA   NM_003045   SLC7A1   solute carrier family 7 (cationic                       amino acid transporter, y+                       system), member 1       1237   Protein   NP_003036   SLC7A1   solute carrier family 7 (cationic                       amino acid transporter, y+                       system), member 1       1238   DNA   NM_002446   MAP3K10   mitogen-activated protein                       kinase kinase kinase 10       1239   Protein   NP_002437   MAP3K10   mitogen-activated protein                       kinase kinase kinase 10       1240   DNA   NM_003429   ZNF85   zinc finger protein 85 (HPF4,                       HTF1)       1241   Protein   NP_003420   ZNF85   zinc finger protein 85 (HPF4,                       HTF1)       1242   DNA   NM_005547   IVL   involucrin       1243   Protein   NP_005538   IVL   involucrin       1244   DNA   NM_000661   RPL9   ribosomal protein L9       1245   Protein   NP_000652   RPL9   ribosomal protein L9       1246   DNA   W28729   EST   EST       1247   DNA   NM_052855   MGC15396   hypothetical protein                       MGC15396       1248   Protein   NP_443087   MGC15396   hypothetical protein                       MGC15396       1249   DNA   NM_004160   PYY   peptide YY       1250   Protein   NP_004151   PYY   peptide YY       1251   DNA   NM_004875   RPA40   RNA polymerase I subunit       1252   Protein   NP_004866   RPA40   RNA polymerase I subunit       1253   DNA   NM_014291   GCAT   glycine C-acetyltransferase (2-                       amino-3-ketobutyrate                       coenzyme A ligase)       1254   Protein   NP_055106   GCAT   glycine C-acetyltransferase (2-                       amino-3-ketobutyrate                       coenzyme A ligase)       1255   DNA   NM_007344   TTF1   transcription termination factor,                       RNA polymerase I       1256   Protein   NP_031370   TTF1   transcription termination factor,                       RNA polymerase I       1257   DNA   NM_005632   SOLH   small optic lobes homolog                       ( Drosophila )       1258   Protein   NP_005623   SOLH   small optic lobes homolog                       ( Drosophila )       1259   DNA   AB011542   EGFL5   EGF-like-domain, multiple 5       1260   Protein   AB011542   EGFL5   EGF-like-domain, multiple 5               (Translation)       1261   DNA   NM_021003   PPM1A   protein phosphatase 1A                       (formerly 2C), magnesium-                       dependent, alpha isoform       1262   Protein   NP_066283   PPM1A   protein phosphatase 1A                       (formerly 2C), magnesium-                       dependent, alpha isoform       1263   DNA   D30612   ZNF282   zinc finger protein 282       1264   Protein   D30612 (Translation)   ZNF282   zinc finger protein 282       1265   DNA   NM_005476   GNE   UDP-N-acetylglucosamine-2-                       epimerase/N-                       acetylmannosamine kinase       1266   Protein   NP_005467   GNE   UDP-N-acetylglucosamine-2-                       epimerase/N-                       acetylmannosamine kinase       1267   DNA   NM_005926   MFAP1   microfibrillar-associated                       protein 1       1268   Protein   NP_005917   MFAP1   microfibrillar-associated                       protein 1       1269   DNA   NM_006359   SLC9A6   solute carrier family 9                       (sodium/hydrogen exchanger),                       isoform 6       1270   Protein   NP_006350   SLC9A6   solute carrier family 9                       (sodium/hydrogen exchanger),                       isoform 6       1271   DNA   NM_003087   SNCG   synuclein, gamma (breast                       cancer-specific protein 1)       1272   Protein   NP_003078   SNCG   synuclein, gamma (breast                       cancer-specific protein 1)       1273   DNA   NM_153341   FLJ90005   hypothetical protein FLJ90005       1274   Protein   NP_699172   FLJ90005   hypothetical protein FLJ90005       1275   DNA   NM_006978   ZNF183   zinc finger protein 183 (RING                       finger, C3HC4 type)       1276   Protein   NP_008909   ZNF183   zinc finger protein 183 (RING                       finger, C3HC4 type)       1277   DNA   NM_004135   IDH3G   isocitrate dehydrogenase 3                       (NAD+) gamma       1278   Protein   NP_004126   IDH3G   isocitrate dehydrogenase 3                       (NAD+) gamma       1279   DNA   NM_174869   IDH3G   isocitrate dehydrogenase 3                       (NAD+) gamma       1280   Protein   NP_777358   IDH3G   isocitrate dehydrogenase 3                       (NAD+) gamma       1281   DNA   NM_001166   BIRC2   baculoviral IAP repeat-                       containing 2       1282   Protein   NP_001157   BIRC2   baculoviral IAP repeat-                       containing 2       1283   DNA   NM_004788   UBE4A   ubiquitination factor E4A                       (UFD2 homolog, yeast)       1284   Protein   NP_004779   UBE4A   ubiquitination factor E4A                       (UFD2 homolog, yeast)       1285   DNA   D87470   KIAA0280   KIAA0280 protein       1286   Protein   D87470 (Translation)   KIAA0280   KIAA0280 protein       1287   DNA   NM_006010   ARMET   arginine-rich, mutated in early                       stage tumors       1288   Protein   NP_006001   ARMET   arginine-rich, mutated in early                       stage tumors       1289   DNA   NM_002165   ID1   inhibitor of DNA binding 1,                       dominant negative helix-loop-                       helix protein       1290   Protein   NP_002156   ID1   inhibitor of DNA binding 1,                       dominant negative helix-loop-                       helix protein       1291   DNA   NM_000454   SOD1   superoxide dismutase 1, soluble                       (amyotrophic lateral sclerosis 1                       (adult))       1292   Protein   NP_000445   SOD1   superoxide dismutase 1, soluble                       (amyotrophic lateral sclerosis 1                       (adult))       1293   DNA   NM_007202   AKAP10   A kinase (PRKA) anchor                       protein 10       1294   Protein   NP_009133   AKAP10   A kinase (PRKA) anchor                       protein 10       1295   DNA   J00287       Cluster Incl. J00287: Human                       pepsinogen gene                       /cds = (55.1221) /gb = J00287                       /gi = 189798 /ug = Hs.75558                       /len = 1381       1296   Protein   J00287 (Translation)       Cluster Incl. J00287: Human                       pepsinogen gene                       /cds = (55.1221) /gb = J00287                       /gi = 189798 /ug = Hs.75558                       /len = 1381       1297   DNA   NM_004357   CD151   CD151 antigen       1298   Protein   NP_004348   CD151   CD151 antigen       1299   DNA   NM_139030   CD151   CD151 antigen       1300   Protein   NP_620599   CD151   CD151 antigen       1301   DNA   NM_139031   CD151   CD151 antigen       1302   DNA   NM_004270   CRSP9   cofactor required for Sp1                       transcriptional activation,                       subunit 9, 33 kDa       1303   Protein   NP_004261   CRSP9   cofactor required for Sp1                       transcriptional activation,                       subunit 9, 33 kDa       1304   DNA   NM_000375   UROS   uroporphyrinogen III synthase                       (congenital erythropoietic                       porphyria)       1305   Protein   NP_000366   UROS   uroporphyrinogen III synthase                       (congenital erythropoietic                       porphyria)       1306   DNA   NM_000155   GALT   galactose-1-phosphate                       uridylyltransferase       1307   Protein   NP_000146   GALT   galactose-1-phosphate                       uridylyltransferase       1308   DNA   NM_147131   GALT   galactose-1-phosphate                       uridylyltransferase       1309   Protein   NP_667342   GALT   galactose-1-phosphate                       uridylyltransferase       1310   DNA   NM_147132   GALT   galactose-1-phosphate                       uridylyltransferase       1311   Protein   NP_667343   GALT   galactose-1-phosphate                       uridylyltransferase       1312   DNA   NM_000918   P4HB   procollagen-proline, 2-                       oxoglutarate 4-dioxygenase                       (proline 4-hydroxylase), beta                       polypeptide (protein disulfide                       isomerase; thyroid hormone                       binding protein p55)       1313   Protein   NP_000909   P4HB   procollagen-proline, 2-                       oxoglutarate 4-dioxygenase                       (proline 4-hydroxylase), beta                       polypeptide (protein disulfide                       isomerase; thyroid hormone                       binding protein p55)       1314   DNA   NM_005022   PFN1   profilin 1       1315   Protein   NP_005013   PFN1   profilin 1       1316   DNA   NM_001647   APOD   apolipoprotein D       1317   Protein   NP_001638   APOD   apolipoprotein D       1318   DNA   NM_153747       Cluster Incl. AB000359:  Homo                           sapiens  PIGCP1 pseudogene                       /cds = (0.416) /gb = AB000359                       /gi = 2547040 /ug = Hs.47974                       /len = 417       1319   Protein   NP_714969       Cluster Incl. AB000359:  Homo                           sapiens  PIGCP1 pseudogene                       /cds = (0.416) /gb = AB000359                       /gi = 2547040 /ug = Hs.47974                       /len = 417       1320   DNA   NM_002642       Cluster Incl. AB000359:  Homo                           sapiens  PIGCP1 pseudogene                       /cds = (0.416) /gb = AB000359                       /gi = 2547040 /ug = Hs.47974                       /len = 417       1321   DNA   AL080093         Homo sapiens  mRNA; cDNA                       DKFZp564N1662 (from clone                       DKFZp564N1662), mRNA                       sequence       1322   DNA   NM_001831   CLU   clusterin (complement lysis                       inhibitor, SP-40,40, sulfated                       glycoprotein 2, testosterone-                       repressed prostate message 2,                       apolipoprotein J)       1323   Protein   NP_001822   CLU   clusterin (complement lysis                       inhibitor, SP-40,40, sulfated                       glycoprotein 2, testosterone-                       repressed prostate message 2,                       apolipoprotein J)       1324   DNA   NM_015852   H-plk   Krueppel-related zinc finger                       protein       1325   Protein   NP_056936   H-plk   Krueppel-related zinc finger                       protein       1326   DNA   NM_001318   CSHL1   chorionic somatomammotropin                       hormone-like 1       1327   Protein   NP_001309   CSHL1   chorionic somatomammotropin                       hormone-like 1       1328   DNA   NM_022578   CSHL1   chorionic somatomammotropin                       hormone-like 1       1329   Protein   NP_072100   CSHL1   chorionic somatomammotropin                       hormone-like 1       1330   DNA   NM_022579   CSHL1   chorionic somatomammotropin                       hormone-like 1       1331   Protein   NP_072101   CSHL1   chorionic somatomammotropin                       hormone-like 1       1332   DNA   NM_022580   CSHL1   chorionic somatomammotropin                       hormone-like 1       1333   Protein   NP_072102   CSHL1   chorionic somatomammotropin                       hormone-like 1       1334   DNA   NM_001540       28 kDa heat shock protein                       [ Homo sapiens ], mRNA                       sequence       1335   Protein   NP_001531       28 kDa heat shock protein                       [ Homo sapiens ], mRNA                       sequence       1336   DNA   NM_007104   RPL10A   ribosomal protein L10a       1337   Protein   NP_009035   RPL10A   ribosomal protein L10a       1338   DNA   NM_002778   PSAP   prosaposin (variant Gaucher                       disease and variant                       metachromatic leukodystrophy)       1339   Protein   NP_002769   PSAP   prosaposin (variant Gaucher                       disease and variant                       metachromatic leukodystrophy)       1340   DNA   NM_001466   FZD2   frizzled homolog 2                       ( Drosophila )       1341   Protein   NP_001457   FZD2   frizzled homolog 2                       ( Drosophila )       1342   DNA   NM_022735   GOCAP1   golgi complex associated                       protein 1, 60 kDa       1343   Protein   NP_073572   GOCAP1   golgi complex associated                       protein 1, 60 kDa       1344   DNA   AB002324   KIAA0326   KIAA0326 protein       1345   Protein   AB002324   KIAA0326   KIAA0326 protein               (Translation)       1346   DNA   NM_006845   KNSL6   kinesin-like 6 (mitotic                       centromere-associated kinesin)       1347   Protein   NP_006836   KNSL6   kinesin-like 6 (mitotic                       centromere-associated kinesin)       1348   DNA   NM_001254   CDC6   CDC6 cell division cycle 6                       homolog ( S. cerevisiae )       1349   Protein   NP_001245   CDC6   CDC6 cell division cycle 6                       homolog ( S. cerevisiae )       1350   DNA   D50926   NXP-2   nuclear matrix protein NXP-2       1351   Protein   D50926 (Translation)   NXP-2   nuclear matrix protein NXP-2       1352   DNA   NM_016199   LSM7   U6 snRNA-associated Sm-like                       protein LSm7       1353   Protein   NP_057283   LSM7   U6 snRNA-associated Sm-like                       protein LSm7       1354   DNA   NM_002853   RAD1   RAD1 homolog ( S. pombe )       1355   Protein   NP_002844   RAD1   RAD1 homolog ( S. pombe )       1356   DNA   NM_133282   RAD1   RAD1 homolog ( S. pombe )       1357   Protein   NP_579816   RAD1   RAD1 homolog ( S. pombe )       1358   DNA   NM_133377   RAD1   RAD1 homolog ( S. pombe )       1359   DNA   NM_015169   RRS1   homolog of yeast ribosome                       biogenesis regulatory protein                       RRS1       1360   Protein   NP_055984   RRS1   homolog of yeast ribosome                       biogenesis regulatory protein                       RRS1       1361   DNA   AB028987   C19orf7   chromosome 19 open reading                       frame 7       1362   Protein   AB028987   C19orf7   chromosome 19 open reading               (Translation)       frame 7       1363   DNA   NM_014213   HOXD9   homeo box D9       1364   Protein   NP_055028   HOXD9   homeo box D9       1365   DNA   NM_003344   UBE2H   ubiquitin-conjugating enzyme                       E2H (UBC8 homolog, yeast)       1366   Protein   NP_003335   UBE2H   ubiquitin-conjugating enzyme                       E2H (UBC8 homolog, yeast)       1367   DNA   NM_001665   ARHG   ras homolog gene family,                       member G (rho G)       1368   Protein   NP_001656   ARHG   ras homolog gene family,                       member G (rho G)       1369   DNA   NM_003188   MAP3K7   mitogen-activated protein                       kinase kinase kinase 7       1370   Protein   NP_003179   MAP3K7   mitogen-activated protein                       kinase kinase kinase 7       1371   DNA   NM_145331   MAP3K7   mitogen-activated protein                       kinase kinase kinase 7       1372   Protein   NP_663304   MAP3K7   mitogen-activated protein                       kinase kinase kinase 7       1373   DNA   NM_145332   MAP3K7   mitogen-activated protein                       kinase kinase kinase 7       1374   Protein   NP_663305   MAP3K7   mitogen-activated protein                       kinase kinase kinase 7       1375   DNA   NM_145333   MAP3K7   mitogen-activated protein                       kinase kinase kinase 7       1376   Protein   NP_663306   MAP3K7   mitogen-activated protein                       kinase kinase kinase 7       1377   DNA   NM_003390   WEE1   WEE1 homolog ( S. pombe )       1378   Protein   NP_003381   WEE1   WEE1 homolog ( S. pombe )       1379   DNA   NM_006527   SLBP   stem-loop (histone) binding                       protein       1380   Protein   NP_006518   SLBP   stem-loop (histone) binding                       protein       1381   DNA   NM_000856   GUCY1A3   guanylate cyclase 1, soluble,                       alpha 3       1382   Protein   NP_000847   GUCY1A3   guanylate cyclase 1, soluble,                       alpha 3       1383   DNA   NM_002748   MAPK6   mitogen-activated protein                       kinase 6       1384   Protein   NP_002739   MAPK6   mitogen-activated protein                       kinase 6       1385   DNA   NM_007145   ZNF146   zinc finger protein 146       1386   Protein   NP_009076   ZNF146   zinc finger protein 146       1387   DNA   NM_003186   TAGLN   transgelin       1388   Protein   NP_003177   TAGLN   transgelin       1389   DNA   NM_014761   KIAA0174   KIAA0174 gene product       1390   Protein   NP_055576   KIAA0174   KIAA0174 gene product       1391   DNA   NM_001396   DYRK1A   dual-specificity tyrosine-(Y)-                       phosphorylation regulated                       kinase 1A       1392   Protein   NP_001387   DYRK1A   dual-specificity tyrosine-(Y)-                       phosphorylation regulated                       kinase 1A       1393   DNA   NM_101395   DYRK1A   dual-specificity tyrosine-(Y)-                       phosphorylation regulated                       kinase 1A       1394   Protein   NP_567824   DYRK1A   dual-specificity tyrosine-(Y)-                       phosphorylation regulated                       kinase 1A       1395   DNA   NM_130436   DYRK1A   dual-specificity tyrosine-(Y)-                       phosphorylation regulated                       kinase 1A       1396   Protein   NP_569120   DYRK1A   dual-specificity tyrosine-(Y)-                       phosphorylation regulated                       kinase 1A       1397   DNA   NM_000182   HADHA   hydroxyacyl-Coenzyme A                       dehydrogenase/3-ketoacyl-                       Coenzyme A thiolase/enoyl-                       Coenzyme A hydratase                       (trifunctional protein), alpha                       subunit       1398   Protein   NP_000173   HADHA   hydroxyacyl-Coenzyme A                       dehydrogenase/3-ketoacyl-                       Coenzyme A thiolase/enoyl-                       Coenzyme A hydratase                       (trifunctional protein), alpha                       subunit       1399   DNA   NM_005359   MADH4   MAD, mothers against                       decapentaplegic homolog 4                       ( Drosophila )       1400   Protein   NP_005350   MADH4   MAD, mothers against                       decapentaplegic homolog 4                       ( Drosophila )       1401   DNA   NM_012408   PRKCBP1   protein kinase C binding                       protein 1       1402   Protein   NP_036540   PRKCBP1   protein kinase C binding                       protein 1       1403   DNA   AL050353   OIP2   Opa-interacting protein 2       1404   DNA   NM_004181   UCHL1   ubiquitin carboxyl-terminal                       esterase L1 (ubiquitin                       thiolesterase)       1405   Protein   NP_004172   UCHL1   ubiquitin carboxyl-terminal                       esterase L1 (ubiquitin                       thiolesterase)       1406   DNA   NM_005626   SFRS4   splicing factor, arginine/serine-                       rich 4       1407   Protein   NP_005617   SFRS4   splicing factor, arginine/serine-                       rich 4       1408   DNA   NM_001694   ATP6V0C   ATPase, H+ transporting,                       lysosomal 16 kDa, V0 subunit c       1409   Protein   NP_001685   ATP6V0C   ATPase, H+ transporting,                       lysosomal 16 kDa, V0 subunit c       1410   DNA   M88249       Cluster Incl. M88249: Human                       inter-alpha-trypsin inhibitor                       light chain (ITI) gene                       /cds = (94.1152) /gb = M88249                       /gi = 186599 /ug = Hs.76177                       /len = 1262       1411   Protein   AAA59196       Cluster Incl. M88249: Human                       inter-alpha-trypsin inhibitor                       light chain (ITI) gene                       /cds = (94.1152) /gb = M88249                       /gi = 186599 /ug = Hs.76177                       /len = 1262       1412   DNA   M80899   AHNAK   AHNAK nucleoprotein                       (desmoyokin)       1413   Protein   M80899   AHNAK   AHNAK nucleoprotein               (Translation)       (desmoyokin)       1414   DNA   NM_014611   MDN1   MDN1, midasin homolog                       (yeast)       1415   Protein   NP_055426   MDN1   MDN1, midasin homolog                       (yeast)       1416   DNA   NM_002167   ID3   inhibitor of DNA binding 3,                       dominant negative helix-loop-                       helix protein       1417   Protein   NP_002158   ID3   inhibitor of DNA binding 3,                       dominant negative helix-loop-                       helix protein       1418   DNA   NM_003300   TRAF3   TNF receptor-associated factor 3       1419   Protein   NP_003291   TRAF3   TNF receptor-associated factor 3       1420   DNA   NM_145725   TRAF3   TNF receptor-associated factor 3       1421   DNA   NM_145726   TRAF3   TNF receptor-associated factor 3       1422   Protein   NP_663778   TRAF3   TNF receptor-associated factor 3       1423   DNA   NM_001462   FPRL1   formyl peptide receptor-like 1       1424   Protein   NP_001453   FPRL1   formyl peptide receptor-like 1       1425   DNA   NM_005649   ZNF354A   zinc finger protein 354A       1426   Protein   NP_005640   ZNF354A   zinc finger protein 354A       1427   DNA   NM_001399   ED1   ectodermal dysplasia 1,                       anhidrotic       1428   Protein   NP_001390   ED1   ectodermal dysplasia 1,                       anhidrotic       1429   DNA   NM_014458   AB026190   Kelch motif containing protein       1430   Protein   NP_055273   AB026190   Kelch motif containing protein       1431   DNA   NM_001813   CENPE   centromere protein E, 312 kDa       1432   Protein   NP_001804   CENPE   centromere protein E, 312 kDa       1433   DNA   NM_002437   MPV17   MpV17 transgene, murine                       homolog, glomerulosclerosis       1434   Protein   NP_002428   MPV17   MpV17 transgene, murine                       homolog, glomerulosclerosis       1435   DNA   NM_012474   UMPK   uridine monophosphate kinase       1436   Protein   NP_036606   UMPK   uridine monophosphate kinase       1437   DNA   NM_012304   FBXL7   F-box and leucine-rich repeat                       protein 7       1438   Protein   NP_036436   FBXL7   F-box and leucine-rich repeat                       protein 7       1439   DNA   NM_005030   PLK   polo-like kinase ( Drosophila )       1440   Protein   NP_005021   PLK   polo-like kinase ( Drosophila )       1441   DNA   NM_001184   ATR   ataxia telangiectasia and Rad3                       related       1442   Protein   NP_001175   ATR   ataxia telangiectasia and Rad3                       related       1443   DNA   NM_014851   KIAA0469   KIAA0469 gene product       1444   Protein   NP_055666   KIAA0469   KIAA0469 gene product       1445   DNA   NM_021222   HTCD37   TcD37 homolog       1446   Protein   NP_067045   HTCD37   TcD37 homolog       1447   DNA   NM_005691   ABCC9   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 9       1448   Protein   NP_005682   ABCC9   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 9       1449   DNA   NM_020297   ABCC9   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 9       1450   Protein   NP_064693   ABCC9   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 9       1451   DNA   NM_020298   ABCC9   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 9       1452   Protein   NP_064694   ABCC9   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 9       1453   DNA   NM_003377   VEGFB   vascular endothelial growth                       factor B       1454   Protein   NP_003368   VEGFB   vascular endothelial growth                       factor B       1455   DNA   NM_005254   GABPB1   GA binding protein                       transcription factor, beta                       subunit 1, 53 kDa       1456   Protein   NP_005245   GABPB1   GA binding protein                       transcription factor, beta                       subunit 1, 53 kDa       1457   DNA   NM_016654   GABPB1   GA binding protein                       transcription factor, beta                       subunit 1, 53 kDa       1458   Protein   NP_057738   GABPB1   GA binding protein                       transcription factor, beta                       subunit 1, 53 kDa       1459   DNA   NM_014745   KIAA0233   KIAA0233 gene product       1460   Protein   NP_055560   KIAA0233   KIAA0233 gene product       1461   DNA   NM_014757   MAML1   mastermind-like 1 ( Drosophila )       1462   Protein   NP_055572   MAML1   mastermind-like 1 ( Drosophila )       1463   DNA   NM_014756   KIAA0097   KIAA0097 gene product       1464   Protein   NP_055571   KIAA0097   KIAA0097 gene product       1465   DNA   NM_002095   GTF2E2   general transcription factor IIE,                       polypeptide 2, beta 34 kDa       1466   Protein   NP_002086   GTF2E2   general transcription factor IIE,                       polypeptide 2, beta 34 kDa       1467   DNA   Z84718       Z84718 /FEATURE = cds#3                       /DEFINITION = HS322B1                       Human DNA sequence from                       clone 322B1 on chromosome                       22q11-12, complete sequence                       [ Homo sapiens ]       1468   DNA   AB002323   DNCH1   dynein, cytoplasmic, heavy                       polypeptide 1       1469   Protein   AB002323   DNCH1   dynein, cytoplasmic, heavy               (Translation)       polypeptide 1       1470   DNA   NM_002070   GNAI2   guanine nucleotide binding                       protein (G protein), alpha                       inhibiting activity polypeptide 2       1471   Protein   NP_002061   GNAI2   guanine nucleotide binding                       protein (G protein), alpha                       inhibiting activity polypeptide 2       1472   DNA   NM_006755   TALDO1   transaldolase 1       1473   Protein   NP_006746   TALDO1   transaldolase 1       1474   DNA   NM_014755   TRIP-Br2   transcriptional regulator                       interacting with the PHS-                       bromodomain 2       1475   Protein   NP_055570   TRIP-Br2   transcriptional regulator                       interacting with the PHS-                       bromodomain 2       1476   DNA   U80017       Cluster Incl. U80017:  Homo                           sapiens  basic transcription                       factor 2 p44 (btf2p44) gene,                       partial cds, neuronal apoptosis                       inhibitory protein (naip) and                       survival motor neuron protein                       (smn) genes, complete cds                       /cds = (33.917) /gb = U80017                       /gi = 1737211 /ug = Hs.77306 /len       1477   Protein   U80017 (Translation)       Cluster Incl. U80017:  Homo                           sapiens  basic transcription                       factor 2 p44 (btf2p44) gene,                       partial cds, neuronal apoptosis                       inhibitory protein (naip) and                       survival motor neuron protein                       (smn) genes, complete cds                       /cds = (33.917) /gb = U80017                       /gi = 1737211 /ug = Hs.77306 /len       1478   DNA   NM_018453   C14orf11   chromosome 14 open reading                       frame 11       1479   Protein   NP_060923   C14orf11   chromosome 14 open reading                       frame 11       1480   DNA   U93305       Cluster Incl. U93305:  Homo                           sapiens  A4 differentiation-                       dependent protein (A4), triple                       LIM domain protein (LMO6),                       and synaptophysin (SYP)                       genes, complete cds; and                       calcium channel alpha-1                       subunit (CACNA1F) gene,                       partial cds /cds = (75.533)                       /gb = U93305 /gi = 270759       1481   Protein   AAB92359       Cluster Incl. U93305:  Homo                           sapiens  A4 differentiation-                       dependent protein (A4), triple                       LIM domain protein (LMO6),                       and synaptophysin (SYP)                       genes, complete cds; and                       calcium channel alpha-1                       subunit (CACNA1F) gene,                       partial cds /cds = (75.533)                       /gb = U93305 /gi = 270759       1482   DNA   NM_007103   NDUFV1   NADH dehydrogenase                       (ubiquinone) flavoprotein 1,                       51 kDa       1483   Protein   NP_009034   NDUFV1   NADH dehydrogenase                       (ubiquinone) flavoprotein 1,                       51 kDa       1484   DNA   NM_002766   PRPSAP1   phosphoribosyl pyrophosphate                       synthetase-associated protein 1       1485   Protein   NP_002757   PRPSAP1   phosphoribosyl pyrophosphate                       synthetase-associated protein 1       1486   DNA   NM_001662   ARF5   ADP-ribosylation factor 5       1487   Protein   NP_001653   ARF5   ADP-ribosylation factor 5       1488   DNA   NM_002346   LY6E   lymphocyte antigen 6 complex,                       locus E       1489   Protein   NP_002337   LY6E   lymphocyte antigen 6 complex,                       locus E       1490   DNA   NM_006736   DNAJB2   DnaJ (Hsp40) homolog,                       subfamily B, member 2       1491   Protein   NP_006727   DNAJB2   DnaJ (Hsp40) homolog,                       subfamily B, member 2       1492   DNA   NM_006801   KDELR1   KDEL (Lys-Asp-Glu-Leu)                       endoplasmic reticulum protein                       retention receptor 1       1493   Protein   NP_006792   KDELR1   KDEL (Lys-Asp-Glu-Leu)                       endoplasmic reticulum protein                       retention receptor 1       1494   DNA   NM_004231   ATP6V1F   ATPase, H+ transporting,                       lysosomal 14 kDa, V1 subunit F       1495   Protein   NP_004222   ATP6V1F   ATPase, H+ transporting,                       lysosomal 14 kDa, V1 subunit F       1496   DNA   NM_000516   GNAS   GNAS complex locus       1497   Protein   NP_000507   GNAS   GNAS complex locus       1498   DNA   NM_016592   GNAS   GNAS complex locus       1499   Protein   NP_057676   GNAS   GNAS complex locus       1500   DNA   NM_080425   GNAS   GNAS complex locus       1501   Protein   NP_536350   GNAS   GNAS complex locus       1502   DNA   NM_002618   PEX13   peroxisome biogenesis factor                       13       1503   Protein   NP_002609   PEX13   peroxisome biogenesis factor                       13       1504   DNA   NM_006638   RPP40   ribonuclease P, 40 kD subunit       1505   Protein   NP_006629   RPP40   ribonuclease P, 40 kD subunit       1506   DNA   NM_017544   NRF   transcription factor NRF       1507   Protein   NP_060014   NRF   transcription factor NRF       1508   DNA   AC004893       Cluster Incl. AC004893:  Homo                           sapiens  PAC clone DJ0808A01                       from 7q21.1-q31.1                       /cds = (0.2138) /gb = AC004893                       /gi = 3694662 /ug = Hs.119120                       /len = 2139       1509   DNA   NM_005063   SCD   stearoyl-CoA desaturase (delta-                       9-desaturase)       1510   Protein   NP_005054   SCD   stearoyl-CoA desaturase (delta-                       9-desaturase)       1511   DNA   NM_012345   NUFIP1   nuclear fragile X mental                       retardation protein interacting                       protein 1       1512   Protein   NP_036477   NUFIP1   nuclear fragile X mental                       retardation protein interacting                       protein 1       1513   DNA   NM_004379   CREB1   cAMP responsive element                       binding protein 1       1514   Protein   NP_004370   CREB1   cAMP responsive element                       binding protein 1       1515   DNA   NM_134442   CREB1   cAMP responsive element                       binding protein 1       1516   Protein   NP_604391   CREB1   cAMP responsive element                       binding protein 1       1517   DNA   D86961   LHFPL2   lipoma HMGIC fusion partner-                       like 2       1518   Protein   D86961 (Translation)   LHFPL2   lipoma HMGIC fusion partner-                       like 2       1519   DNA   AL031778       Cluster Incl.                       AL031778: dJ34B21.4.1                       (nuclear transcription factor Y,                       alpha (CCAAT-Binding                       transcription factor subunit B,                       CBF-B, CAAT-Box DNA                       binding pr /cds = (175.1218)                       /gb = AL031778 /gi = 4153958                       /ug = Hs.797 /len = 3778       1520   DNA   NM_015517   MIZF   MBD2 (methyl-CpG-binding                       protein)-interacting zinc finger                       protein       1521   Protein   NP_056332   MIZF   MBD2 (methyl-CpG-binding                       protein)-interacting zinc finger                       protein       1522   DNA   X98834   SALL2   sal-like 2 ( Drosophila )       1523   DNA   NM_004425   ECM1   extracellular matrix protein 1       1524   Protein   NP_004416   ECM1   extracellular matrix protein 1       1525   DNA   NM_022664   ECM1   extracellular matrix protein 1       1526   Protein   NP_073155   ECM1   extracellular matrix protein 1       1527   DNA   NM_000156   GAMT   guanidinoacetate N-                       methyltransferase       1528   Protein   NP_000147   GAMT   guanidinoacetate N-                       methyltransferase       1529   DNA   NM_138924   GAMT   guanidinoacetate N-                       methyltransferase       1530   Protein   NP_620279   GAMT   guanidinoacetate N-                       methyltransferase       1531   DNA   NM_018224   FLJ10803   hypothetical protein FLJ10803       1532   Protein   NP_060694   FLJ10803   hypothetical protein FLJ10803       1533   DNA   NM_018999   KIAA1128   KIAA1128 protein       1534   Protein   NP_061872   KIAA1128   KIAA1128 protein       1535   DNA   NM_004502   HOXB7   homeo box B7       1536   Protein   NP_004493   HOXB7   homeo box B7       1537   DNA   NM_017790   RGS3   regulator of G-protein                       signalling 3       1538   Protein   NP_060260   RGS3   regulator of G-protein                       signalling 3       1539   DNA   NM_021106   RGS3   regulator of G-protein                       signalling 3       1540   Protein   NP_066929   RGS3   regulator of G-protein                       signalling 3       1541   DNA   NM_130795   RGS3   regulator of G-protein                       signalling 3       1542   Protein   NP_570613   RGS3   regulator of G-protein                       signalling 3       1543   DNA   NM_134427   RGS3   regulator of G-protein                       signalling 3       1544   Protein   NP_602299   RGS3   regulator of G-protein                       signalling 3       1545   DNA   NM_032182   KIAA0157   KIAA0157 protein       1546   Protein   NP_115558   KIAA0157   KIAA0157 protein       1547   DNA   NM_013446   MKRN1   makorin, ring finger protein, 1       1548   Protein   NP_038474   MKRN1   makorin, ring finger protein, 1       1549   DNA   NM_015156   RCOR   REST corepressor       1550   Protein   NP_055971   RCOR   REST corepressor       1551   DNA   NM_001682   ATP2B1   ATPase, Ca++ transporting,                       plasma membrane 1       1552   Protein   NP_001673   ATP2B1   ATPase, Ca++ transporting,                       plasma membrane 1       1553   DNA   NM_003342   UBE2G1   ubiquitin-conjugating enzyme                       E2G 1 (UBC7 homolog,  C. elegans )       1554   Protein   NP_003333   UBE2G1   ubiquitin-conjugating enzyme                       E2G 1 (UBC7 homolog,  C. elegans )       1555   DNA   NM_003470   USP7   ubiquitin specific protease 7                       (herpes virus-associated)       1556   Protein   NP_003461   USP7   ubiquitin specific protease 7                       (herpes virus-associated)       1557   DNA   NM_000688   ALAS1   aminolevulinate, delta-,                       synthase 1       1558   Protein   NP_000679   ALAS1   aminolevulinate, delta-,                       synthase 1       1559   DNA   NM_005153   USP10   ubiquitin specific protease 10       1560   Protein   NP_005144   USP10   ubiquitin specific protease 10       1561   DNA   NM_003362   UNG   uracil-DNA glycosylase       1562   Protein   NP_003353   UNG   uracil-DNA glycosylase       1563   DNA   NM_080911   UNG   uracil-DNA glycosylase       1564   Protein   NP_550433   UNG   uracil-DNA glycosylase       1565   DNA   NM_015153   PHF3   PHD finger protein 3       1566   Protein   NP_055968   PHF3   PHD finger protein 3       1567   DNA   NM_003488   AKAP1   A kinase (PRKA) anchor                       protein 1       1568   Protein   NP_003479   AKAP1   A kinase (PRKA) anchor                       protein 1       1569   DNA   NM_139275   AKAP1   A kinase (PRKA) anchor                       protein 1       1570   Protein   NP_644804   AKAP1   A kinase (PRKA) anchor                       protein 1       1571   DNA   NM_004582   RABGGTB   Rab geranylgeranyltransferase,                       beta subunit       1572   Protein   NP_004573   RABGGTB   Rab geranylgeranyltransferase,                       beta subunit       1573   DNA   NM_002713   PPP1R8   protein phosphatase 1,                       regulatory (inhibitor) subunit 8       1574   Protein   NP_002704   PPP1R8   protein phosphatase 1,                       regulatory (inhibitor) subunit 8       1575   DNA   NM_014110   PPP1R8   protein phosphatase 1,                       regulatory (inhibitor) subunit 8       1576   Protein   NP_054829   PPP1R8   protein phosphatase 1,                       regulatory (inhibitor) subunit 8       1577   DNA   NM_138558   PPP1R8   protein phosphatase 1,                       regulatory (inhibitor) subunit 8       1578   Protein   NP_612568   PPP1R8   protein phosphatase 1,                       regulatory (inhibitor) subunit 8       1579   DNA   NM_004354         Homo sapiens  mRNA; cDNA                       DKFZp434B142 (from clone                       DKFZp434B142), mRNA                       sequence       1580   Protein   NP_004345         Homo sapiens  mRNA; cDNA                       DKFZp434B142 (from clone                       DKFZp434B142), mRNA                       sequence       1581   DNA   NM_012234   RYBP   RING1 and YY1 binding                       protein       1582   Protein   NP_036366   RYBP   RING1 and YY1 binding                       protein       1583   DNA   NM_001315   MAPK14   mitogen-activated protein                       kinase 14       1584   Protein   NP_001306   MAPK14   mitogen-activated protein                       kinase 14       1585   DNA   NM_139012   MAPK14   mitogen-activated protein                       kinase 14       1586   Protein   NP_620581   MAPK14   mitogen-activated protein                       kinase 14       1587   DNA   NM_139013   MAPK14   mitogen-activated protein                       kinase 14       1588   Protein   NP_620582   MAPK14   mitogen-activated protein                       kinase 14       1589   DNA   NM_139014   MAPK14   mitogen-activated protein                       kinase 14       1590   Protein   NP_620583   MAPK14   mitogen-activated protein                       kinase 14       1591   DNA   NM_014962   BTBD3   BTB (POZ) domain containing 3       1592   Protein   NP_055777   BTBD3   BTB (POZ) domain containing 3       1593   DNA   NM_006340   BAIAP2   BAI1-associated protein 2       1594   Protein   NP_006331   BAIAP2   BAI1-associated protein 2       1595   DNA   NM_017450   BAIAP2   BAI1-associated protein 2       1596   Protein   NP_059344   BAIAP2   BAI1-associated protein 2       1597   DNA   NM_017451   BAIAP2   BAI1-associated protein 2       1598   Protein   NP_059345   BAIAP2   BAI1-associated protein 2       1599   DNA   AL049227         Homo sapiens  mRNA; cDNA                       DKFZp564N1116 (from clone                       DKFZp564N1116), mRNA                       sequence       1600   DNA   NM_012066   20D7-FC4   hypothetical protein 20D7-FC4       1601   Protein   NP_036198   20D7-FC4   hypothetical protein 20D7-FC4       1602   DNA   NM_006675   NET-5   transmembrane 4 superfamily                       member tetraspan NET-5       1603   Protein   NP_006666   NET-5   transmembrane 4 superfamily                       member tetraspan NET-5       1604   DNA   AL080062   DKFZP564I122   DKFZP564I122 protein       1605   Protein   AL080062   DKFZP564I122   DKFZP564I122 protein               (Translation)       1606   DNA   NM_005677   COLQ   collagen-like tail subunit                       (single strand of homotrimer)                       of asymmetric                       acetylcholinesterase       1607   Protein   NP_005668   COLQ   collagen-like tail subunit                       (single strand of homotrimer)                       of asymmetric                       acetylcholinesterase       1608   DNA   NM_080538   COLQ   collagen-like tail subunit                       (single strand of homotrimer)                       of asymmetric                       acetylcholinesterase       1609   Protein   NP_536799   COLQ   collagen-like tail subunit                       (single strand of homotrimer)                       of asymmetric                       acetylcholinesterase       1610   DNA   NM_080539   COLQ   collagen-like tail subunit                       (single strand of homotrimer)                       of asymmetric                       acetylcholinesterase       1611   Protein   NP_536800   COLQ   collagen-like tail subunit                       (single strand of homotrimer)                       of asymmetric                       acetylcholinesterase       1612   DNA   NM_015064   ELKS   ELKS protein       1613   Protein   NP_055879   ELKS   ELKS protein       1614   DNA   NM_005513   GTF2E1   general transcription factor IIE,                       polypeptide 1, alpha 56 kDa       1615   Protein   NP_005504   GTF2E1   general transcription factor IIE,                       polypeptide 1, alpha 56 kDa       1616   DNA   NM_013310   AF038169   hypothetical protein AF038169       1617   Protein   NP_037442   AF038169   hypothetical protein AF038169       1618   DNA   NM_003846   PEX11B   peroxisomal biogenesis factor                       11B       1619   Protein   NP_003837   PEX11B   peroxisomal biogenesis factor                       11B       1620   DNA   NM_014602   PIK3R4   phosphoinositide-3-kinase,                       regulatory subunit 4, p150       1621   Protein   NP_055417   PIK3R4   phosphoinositide-3-kinase,                       regulatory subunit 4, p150       1622   DNA   NM_012151   F8A   coagulation factor VIII-                       associated (intronic transcript)       1623   Protein   NP_036283   F8A   coagulation factor VIII-                       associated (intronic transcript)       1624   DNA   NM_005334   HCFC1   host cell factor C1 (VP16-                       accessory protein)       1625   Protein   NP_005325   HCFC1   host cell factor C1 (VP16-                       accessory protein)       1626   DNA   NM_004295   TRAF4   TNF receptor-associated factor 4       1627   Protein   NP_004286   TRAF4   TNF receptor-associated factor 4       1628   DNA   NM_145751   TRAF4   TNF receptor-associated factor 4       1629   Protein   NP_665694   TRAF4   TNF receptor-associated factor 4       1630   DNA   NM_019005   FLJ20323   hypothetical protein FLJ20323       1631   Protein   NP_061878   FLJ20323   hypothetical protein FLJ20323       1632   DNA   NM_002653   PITX1   paired-like homeodomain                       transcription factor 1       1633   Protein   NP_002644   PITX1   paired-like homeodomain                       transcription factor 1       1634   DNA   NM_001810   CENPB   centromere protein B, 80 kDa       1635   Protein   NP_001801   CENPB   centromere protein B, 80 kDa       1636   DNA   NM_004239   TRIP11   thyroid hormone receptor                       interactor 11       1637   Protein   NP_004230   TRIP11   thyroid hormone receptor                       interactor 11       1638   DNA   NM_006910   RBBP6   retinoblastoma binding protein 6       1639   Protein   NP_008841   RBBP6   retinoblastoma binding protein 6       1640   DNA   NM_004697   PRPF4   PRP4 pre-mRNA processing                       factor 4 homolog (yeast)       1641   Protein   NP_004688   PRPF4   PRP4 pre-mRNA processing                       factor 4 homolog (yeast)       1642   DNA   NM_018096   FLJ10458   hypothetical protein similar to                       beta-transducin family       1643   Protein   NP_060566   FLJ10458   hypothetical protein similar to                       beta-transducin family       1644   DNA   NM_014255   TMEM4   transmembrane protein 4       1645   Protein   NP_055070   TMEM4   transmembrane protein 4       1646   DNA   NM_014001   GGA3   golgi associated, gamma                       adaptin ear containing, ARF                       binding protein 3       1647   Protein   NP_054720   GGA3   golgi associated, gamma                       adaptin ear containing, ARF                       binding protein 3       1648   DNA   NM_138619   GGA3   golgi associated, gamma                       adaptin ear containing, ARF                       binding protein 3       1649   Protein   NP_619525   GGA3   golgi associated, gamma                       adaptin ear containing, ARF                       binding protein 3       1650   DNA   NM_003629   PIK3R3   phosphoinositide-3-kinase,                       regulatory subunit, polypeptide                       3 (p55, gamma)       1651   Protein   NP_003620   PIK3R3   phosphoinositide-3-kinase,                       regulatory subunit, polypeptide                       3 (p55, gamma)       1652   DNA   NM_153250   MGC40413   hypothetical protein                       MGC40413       1653   Protein   NP_694982   MGC40413   hypothetical protein                       MGC40413       1654   DNA   NM_001663   ARF6   ADP-ribosylation factor 6       1655   Protein   NP_001654   ARF6   ADP-ribosylation factor 6       1656   DNA   NM_001687   ATP5D   ATP synthase, H+ transporting,                       mitochondrial F1 complex,                       delta subunit       1657   Protein   NP_001678   ATP5D   ATP synthase, H+ transporting,                       mitochondrial F1 complex,                       delta subunit       1658   DNA   NM_001894   CSNK1E   casein kinase 1, epsilon       1659   Protein   NP_001885   CSNK1E   casein kinase 1, epsilon       1660   DNA   NM_152221   CSNK1E   casein kinase 1, epsilon       1661   DNA   NM_005871   SPF30   splicing factor 30, survival of                       motor neuron-related       1662   Protein   NP_005862   SPF30   splicing factor 30, survival of                       motor neuron-related       1663   DNA   AL080234         Homo sapiens  clone FBD3 Cri-                       du-chat critical region mRNA,                       mRNA sequence       1664   DNA   NM_003799   RNMT   RNA (guanine-7-)                       methyltransferase       1665   Protein   NP_003790   RNMT   RNA (guanine-7-)                       methyltransferase       1666   DNA   NM_015144   BDG-29   BDG-29 proten       1667   Protein   NP_055959   BDG-29   BDG-29 proten       1668   DNA   NM_032909   BDG-29   BDG-29 proten       1669   DNA   AB014542   TNRC15   trinucleotide repeat containing                       15       1670   Protein   AB014542   TNRC15   trinucleotide repeat containing               (Translation)       15       1671   DNA   NM_001359   DECR1   2,4-dienoyl CoA reductase 1,                       mitochondrial       1672   Protein   NP_001350   DECR1   2,4-dienoyl CoA reductase 1,                       mitochondrial       1673   DNA   NM_023012   FLJ11021   hypothetical protein FLJ11021                       similar to splicing factor,                       arginine/serine-rich 4       1674   Protein   NP_075388   FLJ11021   hypothetical protein FLJ11021                       similar to splicing factor,                       arginine/serine-rich 4       1675   DNA   NM_006265   RAD21   RAD21 homolog ( S. pombe )       1676   Protein   NP_006256   RAD21   RAD21 homolog ( S. pombe )       1677   DNA   NM_007275   FUS1   lung cancer candidate       1678   Protein   NP_009206   FUS1   lung cancer candidate       1679   DNA   NM_002391   MDK   midkine (neurite growth-                       promoting factor 2)       1680   Protein   NP_002382   MDK   midkine (neurite growth-                       promoting factor 2)       1681   DNA   NM_007061   CDC42EP1   CDC42 effector protein (Rho                       GTPase binding) 1       1682   Protein   NP_008992   CDC42EP1   CDC42 effector protein (Rho                       GTPase binding) 1       1683   DNA   NM_152243   CDC42EP1   CDC42 effector protein (Rho                       GTPase binding) 1       1684   Protein   NP_689449   CDC42EP1   CDC42 effector protein (Rho                       GTPase binding) 1       1685   DNA   NM_005620   S100A11   S100 calcium binding protein                       A11 (calgizzarin)       1686   Protein   NP_005611   S100A11   S100 calcium binding protein                       A11 (calgizzarin)       1687   DNA   NM_004075   CRY1   cryptochrome 1 (photolyase-                       like)       1688   Protein   NP_004066   CRY1   cryptochrome 1 (photolyase-                       like)       1689   DNA   NM_017503   SURF2   surfeit 2       1690   Protein   NP_059973   SURF2   surfeit 2       1691   DNA   NM_001478   GALGT   UDP-N-acetyl-alpha-D-                       galactosamine:(N-                       acetylneuraminyl)-                       galactosylglucosylceramide N-                       acetylgalactosaminyltransferase                       (GalNAc-T)       1692   Protein   NP_001469   GALGT   UDP-N-acetyl-alpha-D-                       galactosamine:(N-                       acetylneuraminyl)-                       galactosylglucosylceramide N-                       acetylgalactosaminyltransferase                       (GalNAc-T)       1693   DNA   NM_000110   DPYD   dihydropyrimidine                       dehydrogenase       1694   Protein   NP_000101   DPYD   dihydropyrimidine                       dehydrogenase       1695   DNA   D26488   KIAA0007   KIAA0007 protein       1696   Protein   D26488 (Translation)   KIAA0007   KIAA0007 protein       1697   DNA   NM_002475   MLC1SA   myosin light chain 1 slow a       1698   Protein   NP_002466   MLC1SA   myosin light chain 1 slow a       1699   DNA   W21827   DKFZP564O092   DKFZP564O092 protein       1700   DNA   NM_002496   NDUFS8   NADH dehydrogenase                       (ubiquinone) Fe—S protein 8,                       23 kDa (NADH-coenzyme Q                       reductase)       1701   Protein   NP_002487   NDUFS8   NADH dehydrogenase                       (ubiquinone) Fe—S protein 8,                       23 kDa (NADH-coenzyme Q                       reductase)       1702   DNA   NM_031206   FLJ12525   hypothetical protein FLJ12525       1703   Protein   NP_112483   FLJ12525   hypothetical protein FLJ12525       1704   DNA   NM_002871   RABIF   RAB interacting factor       1705   Protein   NP_002862   RABIF   RAB interacting factor       1706   DNA   NM_003631   PARG   poly (ADP-ribose)                       glycohydrolase       1707   Protein   NP_003622   PARG   poly (ADP-ribose)                       glycohydrolase       1708   DNA   NM_007026   DUSP14   dual specificity phosphatase 14       1709   Protein   NP_008957   DUSP14   dual specificity phosphatase 14       1710   DNA   NM_007024   PL6   PL6 protein       1711   Protein   NP_008955   PL6   PL6 protein       1712   DNA   NM_003815   ADAM15   a disintegrin and                       metalloproteinase domain 15                       (metargidin)       1713   Protein   NP_003806   ADAM15   a disintegrin and                       metalloproteinase domain 15                       (metargidin)       1714   DNA   NM_004215   EBAG9   estrogen receptor binding site                       associated, antigen, 9       1715   Protein   NP_004206   EBAG9   estrogen receptor binding site                       associated, antigen, 9       1716   DNA   NM_006421   BIG1   brefeldin A-inhibited guanine                       nucleotide-exchange protein 1       1717   Protein   NP_006412   BIG1   brefeldin A-inhibited guanine                       nucleotide-exchange protein 1       1718   DNA   NM_014284   NCDN   neurochondrin       1719   Protein   NP_055099   NCDN   neurochondrin       1720   DNA   NM_021809   TGIF2   TGFB-induced factor 2 (TALE                       family homeobox)       1721   Protein   NP_068581   TGIF2   TGFB-induced factor 2 (TALE                       family homeobox)       1722   DNA   NM_015125   CIC   capicua homolog ( Drosophila )       1723   Protein   NP_055940   CIC   capicua homolog ( Drosophila )       1724   DNA   NM_004897   MINPP1   multiple inositol polyphosphate                       histidine phosphatase, 1       1725   Protein   NP_004888   MINPP1   multiple inositol polyphosphate                       histidine phosphatase, 1       1726   DNA   NM_006928   SILV   silver homolog (mouse)       1727   Protein   NP_008859   SILV   silver homolog (mouse)       1728   DNA   NM_015288   KIAA0239   KIAA0239 protein       1729   Protein   NP_056103   KIAA0239   KIAA0239 protein       1730   DNA   NM_006322   TUBGCP3   tubulin, gamma complex                       associated protein 3       1731   Protein   NP_006313   TUBGCP3   tubulin, gamma complex                       associated protein 3       1732   DNA   AL049321         Homo sapiens  mRNA; cDNA                       DKFZp564D156 (from clone                       DKFZp564D156), mRNA                       sequence       1733   DNA   NM_007010   ROK1   ATP-dependent RNA helicase       1734   Protein   NP_008941   ROK1   ATP-dependent RNA helicase       1735   DNA   NM_152300   ROK1   ATP-dependent RNA helicase       1736   Protein   NP_689513   ROK1   ATP-dependent RNA helicase       1737   DNA   NM_001155   ANXA6   annexin A6       1738   Protein   NP_001146   ANXA6   annexin A6       1739   DNA   NM_004033   ANXA6   annexin A6       1740   Protein   NP_004024   ANXA6   annexin A6       1741   DNA   NM_007005   BCE-1   BCE-1 protein       1742   Protein   NP_008936   BCE-1   BCE-1 protein       1743   DNA   NM_000202   IDS   iduronate 2-sulfatase (Hunter                       syndrome)       1744   Protein   NP_000193   IDS   iduronate 2-sulfatase (Hunter                       syndrome)       1745   DNA   NM_006123   IDS   iduronate 2-sulfatase (Hunter                       syndrome)       1746   Protein   NP_006114   IDS   iduronate 2-sulfatase (Hunter                       syndrome)       1747   DNA   NM_000018   ACADVL   acyl-Coenzyme A                       dehydrogenase, very long chain       1748   Protein   NP_000009   ACADVL   acyl-Coenzyme A                       dehydrogenase, very long chain       1749   DNA   NM_006766   ZNF220   zinc finger protein 220       1750   Protein   NP_006757   ZNF220   zinc finger protein 220       1751   DNA   NM_003682   MADD   MAP-kinase activating death                       domain       1752   Protein   NP_003673   MADD   MAP-kinase activating death                       domain       1753   DNA   NM_130470   MADD   MAP-kinase activating death                       domain       1754   Protein   NP_569826   MADD   MAP-kinase activating death                       domain       1755   DNA   NM_130471   MADD   MAP-kinase activating death                       domain       1756   Protein   NP_569827   MADD   MAP-kinase activating death                       domain       1757   DNA   NM_130472   MADD   MAP-kinase activating death                       domain       1758   Protein   NP_569828   MADD   MAP-kinase activating death                       domain       1759   DNA   AF070546   DKFZp451J0118   hypothetical protein                       DKFZp451J0118       1760   DNA   NM_001450   FHL2   four and a half LIM domains 2       1761   Protein   NP_001441   FHL2   four and a half LIM domains 2       1762   DNA   NM_007359   MLN51   MLN51 protein       1763   Protein   NP_031385   MLN51   MLN51 protein       1764   DNA   AA015605   FLJ20811   hypothetical protein FLJ20811       1765   DNA   NM_006830   UQCR   ubiquinol-cytochrome c                       reductase (6.4 kD) subunit       1766   Protein   NP_006821   UQCR   ubiquinol-cytochrome c                       reductase (6.4 kD) subunit       1767   DNA   NM_006302   GCS1   glucosidase I       1768   Protein   NP_006293   GCS1   glucosidase I       1769   DNA   NM_001383   DPH2L1   diptheria toxin resistance                       protein required for                       diphthamide biosynthesis-like 1                       ( S. cerevisiae )       1770   Protein   NP_001374   DPH2L1   diptheria toxin resistance                       protein required for                       diphthamide biosynthesis-like 1                       ( S. cerevisiae )       1771   DNA   NM_004592   SFRS8   splicing factor, arginine/serine-                       rich 8 (suppressor-of-white-                       apricot homolog,  Drosophila )       1772   Protein   NP_004583   SFRS8   splicing factor, arginine/serine-                       rich 8 (suppressor-of-white-                       apricot homolog,  Drosophila )       1773   DNA   NM_152235   SFRS8   splicing factor, arginine/serine-                       rich 8 (suppressor-of-white-                       apricot homolog,  Drosophila )       1774   Protein   NP_689421   SFRS8   splicing factor, arginine/serine-                       rich 8 (suppressor-of-white-                       apricot homolog,  Drosophila )       1775   DNA   NM_015029   POP1   processing of precursors 1       1776   Protein   NP_055844   POP1   processing of precursors 1       1777   DNA   NM_014783   ARHGAP11A   KIAA0013 gene product       1778   Protein   NP_055598   ARHGAP11A   KIAA0013 gene product       1779   DNA   NM_002936   RNASEH1   ribonuclease H1       1780   Protein   NP_002927   RNASEH1   ribonuclease H1       1781   DNA   NM_005802   TP53BPL   tumor protein p53-binding                       protein       1782   Protein   NP_005793   TP53BPL   tumor protein p53-binding                       protein       1783   DNA   NM_002072         Homo sapiens  mRNA; cDNA                       DKFZp686D0521 (from clone                       DKFZp686D0521), mRNA                       sequence       1784   Protein   NP_002063         Homo sapiens  mRNA; cDNA                       DKFZp686D0521 (from clone                       DKFZp686D0521), mRNA                       sequence       1785   DNA   NM_000578   SLC11A1   solute carrier family 11                       (proton-coupled divalent metal                       ion transporters), member 1       1786   Protein   NP_000569   SLC11A1   solute carrier family 11                       (proton-coupled divalent metal                       ion transporters), member 1       1787   DNA   NM_000421   KRT10   keratin 10 (epidermolytic                       hyperkeratosis; keratosis                       palmaris et plantaris)       1788   Protein   NP_000412   KRT10   keratin 10 (epidermolytic                       hyperkeratosis; keratosis                       palmaris et plantaris)       1789   DNA   NM_006349   CG1I   putative cyclin G1 interacting                       protein       1790   Protein   NP_006340   CG1I   putative cyclin G1 interacting                       protein       1791   DNA   AC002073       Cluster Incl. AC002073: Human                       PAC clone DJ515N1 from                       22q11.2-q22 /cds = (0.2201)                       /gb = AC002073 /gi = 2078469                       /ug = Hs.100623 /len = 2202       1792   Protein   AAB54054       Cluster Incl. AC002073: Human                       PAC clone DJ515N1 from                       22q11.2-q22 /cds = (0.2201)                       /gb = AC002073 /gi = 2078469                       /ug = Hs.100623 /len = 2202       1793   DNA   NM_002126   HLF   hepatic leukemia factor       1794   Protein   NP_002117   HLF   hepatic leukemia factor       1795   DNA   NM_006280   SSR4   signal sequence receptor, delta                       (translocon-associated protein                       delta)       1796   Protein   NP_006271   SSR4   signal sequence receptor, delta                       (translocon-associated protein                       delta)       1797   DNA   NM_007263   COPE   coatomer protein complex,                       subunit epsilon       1798   Protein   NP_009194   COPE   coatomer protein complex,                       subunit epsilon       1799   DNA   NM_133476   ZNF384   zinc finger protein 384       1800   Protein   NP_597733   ZNF384   zinc finger protein 384       1801   DNA   NM_024056   MGC5576   hypothetical protein MGC5576       1802   Protein   NP_076961   MGC5576   hypothetical protein MGC5576       1803   DNA   NM_007373   SHOC2   soc-2 suppressor of clear                       homolog ( C. elegans )       1804   Protein   NP_031399   SHOC2   soc-2 suppressor of clear                       homolog ( C. elegans )       1805   DNA   NM_004762   PSCD1   pleckstrin homology, Sec7 and                       coiled/coil domains 1(cytohesin                       1)       1806   Protein   NP_004753   PSCD1   pleckstrin homology, Sec7 and                       coiled/coil domains 1(cytohesin                       1)       1807   DNA   NM_017456   PSCD1   pleckstrin homology, Sec7 and                       coiled/coil domains 1(cytohesin                       1)       1808   Protein   NP_059430   PSCD1   pleckstrin homology, Sec7 and                       coiled/coil domains 1(cytohesin                       1)       1809   DNA   NM_018847   KIAA1354   KIAA1354 protein       1810   Protein   NP_061335   KIAA1354   KIAA1354 protein       1811   DNA   NM_003093   SNRPC   small nuclear ribonucleoprotein                       polypeptide C       1812   Protein   NP_003084   SNRPC   small nuclear ribonucleoprotein                       polypeptide C       1813   DNA   NM_006948   STCH   stress 70 protein chaperone,                       microsome-associated, 60 kDa       1814   Protein   NP_008879   STCH   stress 70 protein chaperone,                       microsome-associated, 60 kDa       1815   DNA   M21259       Cluster Incl. M21259: Human                       Alu repeats in the region 5 to                       the small nuclear                       ribonucleoprotein E gene                       /cds = (0.278) /gb = M21259                       /gi = 338258 /ug = Hs.1066                       /len = 446       1816   DNA   NM_014306   HSPC117   hypothetical protein HSPC117       1817   Protein   NP_055121   HSPC117   hypothetical protein HSPC117       1818   DNA   NM_001261   CDK9   cyclin-dependent kinase 9                       (CDC2-related kinase)       1819   Protein   NP_001252   CDK9   cyclin-dependent kinase 9                       (CDC2-related kinase)       1820   DNA   NM_017443   POLE3   polymerase (DNA directed),                       epsilon 3 (p17 subunit)       1821   Protein   NP_059139   POLE3   polymerase (DNA directed),                       epsilon 3 (p17 subunit)       1822   DNA   AB014527   CLASP2   cytoplasmic linker associated                       protein 2       1823   Protein   AB014527   CLASP2   cytoplasmic linker associated               (Translation)       protein 2       1824   DNA   NM_004599         Homo sapiens  sterol regulatory                       element binding transcription                       factor 2 (SREBF2), mRNA       1825   Protein   NP_004590       Sterol regulatory element-                       binding transcription factor 2;                       sterol regulatory element-                       binding protein 2 [ Homo                           sapiens ]       1826   DNA   NM_013318   KIAA0515   KIAA0515 protein       1827   Protein   NP_037450   KIAA0515   KIAA0515 protein       1828   DNA   D86978   C7orf14   chromosome 7 open reading                       frame 14       1829   Protein   D86978 (Translation)   C7orf14   chromosome 7 open reading                       frame 14       1830   DNA   AB020671   KIAA0864   KIAA0864 protein       1831   Protein   AB020671   KIAA0864   KIAA0864 protein               (Translation)       1832   DNA   NM_144586   MGC29643   hypothetical protein                       MGC29643       1833   Protein   NP_653187   MGC29643   hypothetical protein                       MGC29643       1834   DNA   NM_007100   ATP5I   ATP synthase, H+ transporting,                       mitochondrial F0 complex,                       subunit e       1835   Protein   NP_009031   ATP5I   ATP synthase, H+ transporting,                       mitochondrial F0 complex,                       subunit e       1836   DNA   NM_003824   FADD   Fas (TNFRSF6)-associated via                       death domain       1837   Protein   NP_003815   FADD   Fas (TNFRSF6)-associated via                       death domain       1838   DNA   NM_014891   PDAP1   PDGFA associated protein 1       1839   Protein   NP_055706   PDAP1   PDGFA associated protein 1       1840   DNA   NM_007372   RNAHP   RNA helicase-related protein       1841   Protein   NP_031398   RNAHP   RNA helicase-related protein       1842   DNA   NM_014928       Cluster Incl. AB028969:  Homo                           sapiens  mRNA for KIAA1046                       protein, complete cds                       /cds = (577.1782)                       /gb = AB028969 /gi = 5689428                       /ug = Hs.89519 /len = 5577       1843   Protein   NP_055743       Cluster Incl. AB028969:  Homo                           sapiens  mRNA for KIAA1046                       protein, complete cds                       /cds = (577.1782)                       /gb = AB028969 /gi = 5689428                       /ug = Hs.89519 /len = 5577       1844   DNA   NM_005216   DDOST   dolichyl-                       diphosphooligosaccharide-                       protein glycosyltransferase       1845   Protein   NP_005207   DDOST   dolichyl-                       diphosphooligosaccharide-                       protein glycosyltransferase       1846   DNA   NM_014233   UBTF   upstream binding transcription                       factor, RNA polymerase I       1847   Protein   NP_055048   UBTF   upstream binding transcription                       factor, RNA polymerase I       1848   DNA   NM_003574   VAPA   VAMP (vesicle-associated                       membrane protein)-associated                       protein A, 33 kDa       1849   Protein   NP_003565   VAPA   VAMP (vesicle-associated                       membrane protein)-associated                       protein A, 33 kDa       1850   DNA   NM_006997   TACC2   transforming, acidic coiled-coil                       containing protein 2       1851   Protein   NP_008928   TACC2   transforming, acidic coiled-coil                       containing protein 2       1852   DNA   NM_018358   FLJ11198   hypothetical protein FLJ11198       1853   Protein   NP_060828   FLJ11198   hypothetical protein FLJ11198       1854   DNA   NM_005273         Homo sapiens  guanine                       nucleotide binding protein (G                       protein), beta polypeptide 2                       (GNB2), mRNA       1855   Protein   NP_005264       guanine nucleotide-binding                       protein, beta-2 subunit; G                       protein, beta-2 subunit       1856   Protein   NP_005264   GNB2   guanine nucleotide binding                       protein (G protein), beta                       polypeptide 2       1857   DNA   NM_007027   TOPBP1   topoisomerase (DNA) II                       binding protein       1858   Protein   NP_008958   TOPBP1   topoisomerase (DNA) II                       binding protein       1859   DNA   NM_005487   HMG2L1   high-mobility group protein 2-                       like 1       1860   Protein   NP_005478   HMG2L1   high-mobility group protein 2-                       like 1       1861   DNA   NM_014791   MELK   maternal embryonic leucine                       zipper kinase       1862   Protein   NP_055606   MELK   maternal embryonic leucine                       zipper kinase       1863   DNA   AB028992   KIAA1069   KIAA1069 protein       1864   Protein   AB028992   KIAA1069   KIAA1069 protein               (Translation)       1865   DNA   NM_003921   BCL10   B-cell CLL/lymphoma 10       1866   Protein   NP_003912   BCL10   B-cell CLL/lymphoma 10       1867   DNA   NM_004799   MADHIP   MAD, mothers against                       decapentaplegic homolog                       ( Drosophila ) interacting                       protein, receptor activation                       anchor       1868   Protein   NP_004790   MADHIP   MAD, mothers against                       decapentaplegic homolog                       ( Drosophila ) interacting                       protein, receptor activation                       anchor       1869   DNA   NM_007323   MADHIP   MAD, mothers against                       decapentaplegic homolog                       ( Drosophila ) interacting                       protein, receptor activation                       anchor       1870   Protein   NP_015562   MADHIP   MAD, mothers against                       decapentaplegic homolog                       ( Drosophila ) interacting                       protein, receptor activation                       anchor       1871   DNA   NM_002912   REV3L   REV3-like, catalytic subunit of                       DNA polymerase zeta (yeast)       1872   Protein   NP_002903   REV3L   REV3-like, catalytic subunit of                       DNA polymerase zeta (yeast)       1873   DNA   NM_005470   SSH3BP1   spectrin SH3 domain binding                       protein 1       1874   Protein   NP_005461   SSH3BP1   spectrin SH3 domain binding                       protein 1       1875   DNA   NM_005955   MTF1   metal-regulatory transcription                       factor 1       1876   Protein   NP_005946   MTF1   metal-regulatory transcription                       factor 1       1877   DNA   NM_004868   GPSN2   glycoprotein, synaptic 2       1878   Protein   NP_004859   GPSN2   glycoprotein, synaptic 2       1879   DNA   NM_138501   GPSN2   glycoprotein, synaptic 2       1880   Protein   NP_612510   GPSN2   glycoprotein, synaptic 2       1881   DNA   NM_007262   DJ-1   RNA-binding protein                       regulatory subunit       1882   Protein   NP_009193   DJ-1   RNA-binding protein                       regulatory subunit       1883   DNA   NM_006451   PAIP1   polyadenylate binding protein-                       interacting protein 1       1884   Protein   NP_006442   PAIP1   polyadenylate binding protein-                       interacting protein 1       1885   DNA   NM_002491   NDUFB3   NADH dehydrogenase                       (ubiquinone) 1 beta                       subcomplex, 3, 12 kDa       1886   Protein   NP_002482   NDUFB3   NADH dehydrogenase                       (ubiquinone) 1 beta                       subcomplex, 3, 12 kDa       1887   DNA   NM_007331   WHSC1   Wolf-Hirschhorn syndrome                       candidate 1       1888   Protein   NP_015627   WHSC1   Wolf-Hirschhorn syndrome                       candidate 1       1889   DNA   NM_014919   WHSC1   Wolf-Hirschhorn syndrome                       candidate 1       1890   Protein   NP_055734   WHSC1   Wolf-Hirschhorn syndrome                       candidate 1       1891   DNA   NM_133330   WHSC1   Wolf-Hirschhorn syndrome                       candidate 1       1892   Protein   NP_579877   WHSC1   Wolf-Hirschhorn syndrome                       candidate 1       1893   DNA   NM_133331   WHSC1   Wolf-Hirschhorn syndrome                       candidate 1       1894   DNA   U55980         Homo sapiens  cDNA:                       FLJ23482 fis, clone                       KAIA03142, mRNA sequence       1895   DNA   AF037989       STAT-induced STAT inhibitor-                       2 [ Homo sapiens ], mRNA                       sequence       1896   Protein   AF037989       STAT-induced STAT inhibitor-               (Translation)       2 [ Homo sapiens ], mRNA                       sequence       1897   DNA   X96924       Cluster Incl. X96924:  H. sapiens                         gene encoding mitochondrial                       citrate transport protein                       /cds = (0.957) /gb = X96924                       /gi = 1770309 /ug = Hs.111024                       /len = 1522       1898   Protein   CAA65633       Cluster Incl. X96924:  H. sapiens                         gene encoding mitochondrial                       citrate transport protein                       /cds = (0.957) /gb = X96924                       /gi = 1770309 /ug = Hs.111024                       /len = 1522       1899   DNA   NM_021079   NMT1   N-myristoyltransferase 1       1900   Protein   NP_066565   NMT1   N-myristoyltransferase 1       1901   DNA   AB018257   ZNF294   zinc finger protein 294       1902   Protein   AB018257   ZNF294   zinc finger protein 294               (Translation)       1903   DNA   NM_014463   LSM3   Lsm3 protein       1904   Protein   NP_055278   LSM3   Lsm3 protein       1905   DNA   NM_004436   ENSA   endosulfine alpha       1906   Protein   NP_004427   ENSA   endosulfine alpha       1907   DNA   NM_004528   MGST3   microsomal glutathione S-                       transferase 3       1908   Protein   NP_004519   MGST3   microsomal glutathione S-                       transferase 3       1909   DNA   NM_005387   NUP98   nucleoporin 98 kDa       1910   Protein   NP_005378   NUP98   nucleoporin 98 kDa       1911   DNA   NM_016320   NUP98   nucleoporin 98 kDa       1912   Protein   NP_057404   NUP98   nucleoporin 98 kDa       1913   DNA   NM_139131   NUP98   nucleoporin 98 kDa       1914   Protein   NP_624357   NUP98   nucleoporin 98 kDa       1915   DNA   NM_139132   NUP98   nucleoporin 98 kDa       1916   Protein   NP_624358   NUP98   nucleoporin 98 kDa       1917   DNA   NM_019059   TOM7   homolog of Tom7 ( S. cerevisiae )       1918   Protein   NP_061932   TOM7   homolog of Tom7 ( S. cerevisiae )       1919   DNA   NM_006423   RABAC1   Rab acceptor 1 (prenylated)       1920   Protein   NP_006414   RABAC1   Rab acceptor 1 (prenylated)       1921   DNA   NM_006022   TSC22   transforming growth factor                       beta-stimulated protein TSC-22       1922   Protein   NP_006013   TSC22   transforming growth factor                       beta-stimulated protein TSC-22       1923   DNA   NM_015902   DD5   progestin induced protein       1924   Protein   NP_056986   DD5   progestin induced protein       1925   DNA   NM_005935   MLLT2   myeloid/lymphoid or mixed-                       lineage leukemia (trithorax                       homolog,  Drosophila );                       translocated to, 2       1926   Protein   NP_005926   MLLT2   myeloid/lymphoid or mixed-                       lineage leukemia (trithorax                       homolog,  Drosophila );                       translocated to, 2       1927   DNA   Y00978       PDC-E2 precursor (AA-54 to                       561) [ Homo sapiens ], mRNA                       sequence       1928   Protein   Y00978 (Translation)       PDC-E2 precursor (AA-54 to                       561) [ Homo sapiens ], mRNA                       sequence       1929   DNA   NM_005720   ARPC1B   actin related protein 2/3                       complex, subunit 1B, 41 kDa       1930   Protein   NP_005711   ARPC1B   actin related protein 2/3                       complex, subunit 1B, 41 kDa       1931   DNA   NM_014706   SART3   squamous cell carcinoma                       antigen recognised by T cells 3       1932   Protein   NP_055521   SART3   squamous cell carcinoma                       antigen recognised by T cells 3       1933   DNA   NM_004698   HPRP3P   U4/U6-associated RNA                       splicing factor       1934   Protein   NP_004689   HPRP3P   U4/U6-associated RNA                       splicing factor       1935   DNA   NM_001360   DHCR7   7-dehydrocholesterol reductase       1936   Protein   NP_001351   DHCR7   7-dehydrocholesterol reductase       1937   DNA   NM_014623   MEA   male-enhanced antigen       1938   Protein   NP_055438   MEA   male-enhanced antigen       1939   DNA   U41843       Dr1-associated corepressor,                       mRNA sequence       1940   Protein   U41843 (Translation)       Dr1-associated corepressor,                       mRNA sequence       1941   DNA   NM_014299   BRD4   bromodomain containing 4       1942   Protein   NP_055114   BRD4   bromodomain containing 4       1943   DNA   NM_058243   BRD4   bromodomain containing 4       1944   Protein   NP_490597   BRD4   bromodomain containing 4       1945   DNA   NM_003103   SON   SON DNA binding protein       1946   Protein   NP_003094   SON   SON DNA binding protein       1947   DNA   NM_032195   SON   SON DNA binding protein       1948   Protein   NP_115571   SON   SON DNA binding protein       1949   DNA   NM_058183   SON   SON DNA binding protein       1950   Protein   NP_478063   SON   SON DNA binding protein       1951   DNA   NM_138925   SON   SON DNA binding protein       1952   Protein   NP_620303   SON   SON DNA binding protein       1953   DNA   NM_138926   SON   SON DNA binding protein       1954   Protein   NP_620304   SON   SON DNA binding protein       1955   DNA   NM_005392   PHF2   PHD finger protein 2       1956   Protein   NP_005383   PHF2   PHD finger protein 2       1957   DNA   NM_024517   PHF2   PHD finger protein 2       1958   Protein   NP_078793   PHF2   PHD finger protein 2       1959   DNA   NM_000175   GPI   glucose phosphate isomerase       1960   Protein   NP_000166   GPI   glucose phosphate isomerase       1961   DNA   NM_017751   FLJ20297   hypothetical protein FLJ20297       1962   Protein   NP_060221   FLJ20297   hypothetical protein FLJ20297       1963   DNA   NM_017951   FLJ20297   hypothetical protein FLJ20297       1964   Protein   NP_060421   FLJ20297   hypothetical protein FLJ20297       1965   DNA   AB018310   KIAA0767   KIAA0767 protein       1966   Protein   AB018310   KIAA0767   KIAA0767 protein               (Translation)       1967   DNA   NM_006097   MYL9   myosin, light polypeptide 9,                       regulatory       1968   Protein   NP_006088   MYL9   myosin, light polypeptide 9,                       regulatory       1969   DNA   NM_005973   PRCC   papillary renal cell carcinoma                       (translocation-associated)       1970   Protein   NP_005964   PRCC   papillary renal cell carcinoma                       (translocation-associated)       1971   DNA   NM_014372   RNF11   ring finger protein 11       1972   Protein   NP_055187   RNF11   ring finger protein 11       1973   DNA   NM_004645   COIL   coilin       1974   Protein   NP_004636   COIL   coilin       1975   DNA   NM_001235   SERPINH2   serine (or cysteine) proteinase                       inhibitor, clade H (heat shock                       protein 47), member 2       1976   Protein   NP_001226   SERPINH2   serine (or cysteine) proteinase                       inhibitor, clade H (heat shock                       protein 47), member 2       1977   DNA   NM_004729   ALTE   Ac-like transposable element       1978   Protein   NP_004720   ALTE   Ac-like transposable element       1979   DNA   NM_006201   PCTK1   PCTAIRE protein kinase 1       1980   Protein   NP_006192   PCTK1   PCTAIRE protein kinase 1       1981   DNA   NM_033018   PCTK1   PCTAIRE protein kinase 1       1982   DNA   NM_033019   PCTK1   PCTAIRE protein kinase 1       1983   Protein   NP_148979   PCTK1   PCTAIRE protein kinase 1       1984   DNA   NM_018074   FLJ10374   hypothetical protein FLJ10374       1985   Protein   NP_060544   FLJ10374   hypothetical protein FLJ10374       1986   DNA   NM_001270   CHD1   chromodomain helicase DNA                       binding protein 1       1987   Protein   NP_001261   CHD1   chromodomain helicase DNA                       binding protein 1       1988   DNA   NM_012191   FUS2   putative tumor suppressor       1989   Protein   NP_036323   FUS2   putative tumor suppressor       1990   DNA   NM_005862   STAG1   stromal antigen 1       1991   Protein   NP_005853   STAG1   stromal antigen 1       1992   Protein   NP_005393   RALA   v-ral simian leukemia viral                       oncogene homolog A (ras                       related)       1993   DNA   NM_007249   KLF12   Kruppel-like factor 12       1994   Protein   NP_009180   KLF12   Kruppel-like factor 12       1995   DNA   NM_016285   KLF12   Kruppel-like factor 12       1996   Protein   NP_057369   KLF12   Kruppel-like factor 12       1997   DNA   NM_013299   HSU79266   protein predicted by clone                       23627       1998   Protein   NP_037431   HSU79266   protein predicted by clone                       23627       1999   DNA   NM_002915   RFC3   replication factor C (activator                       1) 3, 38 kDa       2000   Protein   NP_002906   RFC3   replication factor C (activator                       1) 3, 38 kDa       2001   DNA   NM_012346   NUP62   nucleoporin 62 kDa       2002   Protein   NP_036478   NUP62   nucleoporin 62 kDa       2003   DNA   NM_016553   NUP62   nucleoporin 62 kDa       2004   Protein   NP_057637   NUP62   nucleoporin 62 kDa       2005   DNA   NM_153718   NUP62   nucleoporin 62 kDa       2006   Protein   NP_714940   NUP62   nucleoporin 62 kDa       2007   DNA   NM_153719   NUP62   nucleoporin 62 kDa       2008   DNA   D64109   TOB2   transducer of ERBB2, 2       2009   Protein   D64109 (Translation)   TOB2   transducer of ERBB2, 2       2010   DNA   NM_001834   CLTB   clathrin, light polypeptide (Lcb)       2011   Protein   NP_001825   CLTB   clathrin, light polypeptide (Lcb)       2012   DNA   NM_007097   CLTB   clathrin, light polypeptide (Lcb)       2013   Protein   NP_009028   CLTB   clathrin, light polypeptide (Lcb)       2014   DNA   NM_018979   PRKWNK1   protein kinase, lysine deficient 1       2015   Protein   NP_061852   PRKWNK1   protein kinase, lysine deficient 1       2016   DNA   NM_019892   PPI5PIV   phosphatidylinositol (4,5)                       bisphosphate 5-phosphatase                       homolog; phosphatidylinositol                       polyphosphate 5-phosphatase                       type IV       2017   Protein   NP_063945   PPI5PIV   phosphatidylinositol (4,5)                       bisphosphate 5-phosphatase                       homolog; phosphatidylinositol                       polyphosphate 5-phosphatase                       type IV       2018   DNA   NM_004069   AP2S1   adaptor-related protein complex                       2, sigma 1 subunit       2019   Protein   NP_004060   AP2S1   adaptor-related protein complex                       2, sigma 1 subunit       2020   DNA   NM_021575   AP2S1   adaptor-related protein complex                       2, sigma 1 subunit       2021   Protein   NP_067586   AP2S1   adaptor-related protein complex                       2, sigma 1 subunit       2022   DNA   NM_016426   GTSE1   G-2 and S-phase expressed 1       2023   Protein   NP_057510   GTSE1   G-2 and S-phase expressed 1       2024   DNA   NM_152696   Nbak2   homeodomain interacting                       protein kinase 1-like protein       2025   Protein   NP_689909   Nbak2   homeodomain interacting                       protein kinase 1-like protein       2026   DNA   NM_032217   GTAR   gene trap ankyrin repeat       2027   Protein   NP_115593   GTAR   gene trap ankyrin repeat       2028   DNA   NM_015271   TRIM2   tripartite motif-containing 2       2029   Protein   NP_056086   TRIM2   tripartite motif-containing 2       2030   DNA   NM_021005   NR2F2   nuclear receptor subfamily 2,                       group F, member 2       2031   Protein   NP_066285   NR2F2   nuclear receptor subfamily 2,                       group F, member 2       2032   DNA   NM_015079   KIAA1055   KIAA1055 protein       2033   Protein   NP_055894   KIAA1055   KIAA1055 protein       2034   DNA   W28264       Unknown (protein for                       MGC: 17296) [ Homo sapiens ],                       mRNA sequence       2035   DNA   NM_021645   KIAA0266   KIAA0266 gene product       2036   Protein   NP_067677   KIAA0266   KIAA0266 gene product       2037   DNA   AL080156   DKFZP434J214   DKFZP434J214 protein       2038   Protein   AL080156   DKFZP434J214   DKFZP434J214 protein               (Translation)       2039   DNA   NM_003449   TRIM26   tripartite motif-containing 26       2040   Protein   NP_003440   TRIM26   tripartite motif-containing 26       2041   DNA   NM_014604   TIP-1   Tax interaction protein 1       2042   Protein   NP_055419   TIP-1   Tax interaction protein 1       2043   DNA   NM_014570   ARFGAP3   ADP-ribosylation factor                       GTPase activating protein 3       2044   Protein   NP_055385   ARFGAP3   ADP-ribosylation factor                       GTPase activating protein 3       2045   DNA   NM_003605   OGT   O-linked N-acetylglucosamine                       (GlcNAc) transferase (UDP-N-                       acetylglucosamine:polypeptide-                       N-acetylglucosaminyl                       transferase)       2046   Protein   NP_003596   OGT   O-linked N-acetylglucosamine                       (GlcNAc) transferase (UDP-N-                       acetylglucosamine:polypeptide-                       N-acetylglucosaminyl                       transferase)       2047   DNA   NM_015898   FBI1   HIV-1 inducer of short                       transcripts binding protein;                       lymphoma related factor       2048   Protein   NP_056982   FBI1   HIV-1 inducer of short                       transcripts binding protein;                       lymphoma related factor       2049   DNA   NM_001564   ING1L   inhibitor of growth family,                       member 1-like       2050   Protein   NP_001555   ING1L   inhibitor of growth family,                       member 1-like       2051   DNA   NM_014292   CBX6   chromobox homolog 6       2052   Protein   NP_055107   CBX6   chromobox homolog 6       2053   DNA   NM_003663   CGGBP1   CGG triplet repeat binding                       protein 1       2054   Protein   NP_003654   CGGBP1   CGG triplet repeat binding                       protein 1       2055   DNA   NM_004329   BMPR1A   bone morphogenetic protein                       receptor, type IA       2056   Protein   NP_004320   BMPR1A   bone morphogenetic protein                       receptor, type IA       2057   DNA   NM_015464   DKFZp564D206   cystine-knot containing                       secreted protein       2058   Protein   NP_056279   DKFZp564D206   cystine-knot containing                       secreted protein       2059   DNA   AI557322         Homo sapiens  cDNA:                       FLJ22256 fis, clone                       HRC02860, mRNA sequence       2060   DNA   AB007928   KIAA0459   KIAA0459 protein       2061   Protein   AB007928   KIAA0459   KIAA0459 protein               (Translation)       2062   DNA   NM_004251   RAB9A   RAB9A, member RAS                       oncogene family       2063   Protein   NP_004242   RAB9A   RAB9A, member RAS                       oncogene family       2064   DNA   NM_003223   TFAP4   transcription factor AP-4                       (activating enhancer binding                       protein 4)       2065   Protein   NP_003214   TFAP4   transcription factor AP-4                       (activating enhancer binding                       protein 4)       2066   DNA   NM_007215   POLG2   polymerase (DNA directed),                       gamma 2, accessory subunit       2067   Protein   NP_009146   POLG2   polymerase (DNA directed),                       gamma 2, accessory subunit       2068   DNA   NM_004312   ARR3   arrestin 3, retinal (X-arrestin)       2069   Protein   NP_004303   ARR3   arrestin 3, retinal (X-arrestin)       2070   DNA   NM_015569   KIAA0820   KIAA0820 protein       2071   Protein   NP_056384   KIAA0820   KIAA0820 protein       2072   DNA   NM_021140   UTX   ubiquitously transcribed                       tetratricopeptide repeat gene, X                       chromosome       2073   Protein   NP_066963   UTX   ubiquitously transcribed                       tetratricopeptide repeat gene, X                       chromosome       2074   DNA   NM_002131   HMGA1   high mobility group AT-hook 1       2075   Protein   NP_002122   HMGA1   high mobility group AT-hook 1       2076   DNA   NM_145899   HMGA1   high mobility group AT-hook 1       2077   Protein   NP_665906   HMGA1   high mobility group AT-hook 1       2078   DNA   NM_145901   HMGA1   high mobility group AT-hook 1       2079   DNA   NM_145902   HMGA1   high mobility group AT-hook 1       2080   DNA   NM_003009   SEPW1   selenoprotein W, 1       2081   Protein   NP_003000   SEPW1   selenoprotein W, 1       2082   DNA   NM_005979   S100A13   S100 calcium binding protein                       A13       2083   Protein   NP_005970   S100A13   S100 calcium binding protein                       A13       2084   DNA   NM_006618   PLU-1   putative DNA/chromatin                       binding motif       2085   Protein   NP_006609   PLU-1   putative DNA/chromatin                       binding motif       2086   DNA   NM_003592   CUL1   cullin 1       2087   Protein   NP_003583   CUL1   cullin 1       2088   DNA   NM_004902   RNPC2   RNA-binding region (RNP1,                       RRM) containing 2       2089   Protein   NP_004893   RNPC2   RNA-binding region (RNP1,                       RRM) containing 2       2090   DNA   NM_003584   DUSP11   dual specificity phosphatase 11                       (RNA/RNP complex 1-                       interacting)       2091   Protein   NP_003575   DUSP11   dual specificity phosphatase 11                       (RNA/RNP complex 1-                       interacting)       2092   DNA   NM_005809   PRDX2   peroxiredoxin 2       2093   Protein   NP_005800   PRDX2   peroxiredoxin 2       2094   DNA   NM_005157   ABL1   v-abl Abelson murine leukemia                       viral oncogene homolog 1       2095   Protein   NP_005148   ABL1   v-abl Abelson murine leukemia                       viral oncogene homolog 1       2096   DNA   NM_007313   ABL1   v-abl Abelson murine leukemia                       viral oncogene homolog 1       2097   Protein   NP_009297   ABL1   v-abl Abelson murine leukemia                       viral oncogene homolog 1       2098   DNA   NM_001356   DDX3   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 3       2099   Protein   NP_001347   DDX3   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 3       2100   DNA   NM_024005   DDX3   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 3       2101   DNA   NM_000938   POLR2B   polymerase (RNA) II (DNA                       directed) polypeptide B,                       140 kDa       2102   Protein   NP_000929   POLR2B   polymerase (RNA) II (DNA                       directed) polypeptide B,                       140 kDa       2103   DNA   NM_005080   XBP1   X-box binding protein 1       2104   Protein   NP_005071   XBP1   X-box binding protein 1       2105   DNA   AL031781   QKI   homolog of mouse quaking                       QKI (KH domain RNA binding                       protein)       2106   DNA   NM_005095   ZNF262   zinc finger protein 262       2107   Protein   NP_005086   ZNF262   zinc finger protein 262       2108   DNA   NM_014837   C1orf16   chromosome 1 open reading                       frame 16       2109   Protein   NP_055652   C1orf16   chromosome 1 open reading                       frame 16       2110   DNA   NM_015057   KIAA0916   KIAA0916 protein       2111   Protein   NP_055872   KIAA0916   KIAA0916 protein       2112   DNA   NM_004094   EIF2S1   eukaryotic translation initiation                       factor 2, subunit 1 alpha, 35 kDa       2113   Protein   NP_004085   EIF2S1   eukaryotic translation initiation                       factor 2, subunit 1 alpha, 35 kDa       2114   DNA   NM_001681   ATP2A2   ATPase, Ca++ transporting,                       cardiac muscle, slow twitch 2       2115   Protein   NP_001672   ATP2A2   ATPase, Ca++ transporting                       cardiac muscle, slow twitch 2       2116   DNA   NM_170665   ATP2A2   ATPase, Ca++ transporting,                       cardiac muscle, slow twitch 2       2117   Protein   NP_733765   ATP2A2   ATPase, Ca++ transporting,                       cardiac muscle, slow twitch 2       2118   DNA   NM_015255   KIAA0349   KIAA0349 protein       2119   Protein   NP_056070   KIAA0349   KIAA0349 protein       2120   DNA   NM_001031   RPS28   ribosomal protein S28       2121   Protein   NP_001022   RPS28   ribosomal protein S28       2122   DNA   NM_006443   RCL   putative c-Myc-responsive       2123   Protein   NP_006434   RCL   putative c-Myc-responsive       2124   DNA   NM_000988   RPL27   ribosomal protein L27       2125   Protein   NP_000979   RPL27   ribosomal protein L27       2126   DNA   U93181   SBF1   SET binding factor 1       2127   Protein   U93181 (Translation)   SBF1   SET binding factor 1       2128   DNA   AC004877       Cluster Incl. AC004877:  Homo                           sapiens  PAC clone DJ0751H13                       from 7q35-qter /cds = (0.1514)                       /gb = AC004877 /gi = 3638954                       /ug = Hs.112158 /len = 1515       2129   Protein   AC004877       Cluster Incl. AC004877:  Homo                 (Translation)         sapiens  PAC clone DJ0751H13                       from 7q35-qter /cds = (0.1514)                       /gb = AC004877 /gi = 3638954                       /ug = Hs.112158 /len = 1515       2130   DNA   NM_003651   CSDA   cold shock domain protein A       2131   Protein   NP_003642   CSDA   cold shock domain protein A       2132   DNA   NM_004694   SLC16A6   solute carrier family 16                       (monocarboxylic acid                       transporters), member 6       2133   Protein   NP_004685   SLC16A6   solute carrier family 16                       (monocarboxylic acid                       transporters), member 6       2134   DNA   AB028986   USP22   ubiquitin specific protease 22       2135   Protein   AB028986   USP22   ubiquitin specific protease 22               (Translation)       2136   DNA   NM_003321   TUFM   Tu translation elongation                       factor, mitochondrial       2137   Protein   NP_003312   TUFM   Tu translation elongation                       factor, mitochondrial       2138   DNA   NM_014473   HSA9761   putative dimethyladenosine                       transferase       2139   Protein   NP_055288   HSA9761   putative dimethyladenosine                       transferase       2140   DNA   NM_014577       Cluster Incl. Z98885: Human                       DNA sequence from clone                       522J7 on chromosome 22q13.3.                       Contains part of a 60S                       Ribosomal protein L5                       pseudogene and a Peregrin                       (BR140) LIKE gene                       downstream of a putative CpG                       island. Contains ESTs, STSs                       and GSSs /cds = (185.3361)                       /gb = Z       2141   Protein   NP_055392       Cluster Incl. Z98885: Human                       DNA sequence from clone                       522J7 on chromosome 22q13.3.                       Contains part of a 60S                       Ribosomal protein L5                       pseudogene and a Peregrin                       (BR140) LIKE gene                       downstream of a putative CpG                       island. Contains ESTs, STSs                       and GSSs /cds = (185.3361)                       /gb = Z       2142   DNA   NM_133370   KIAA1966   KIAA1966 protein       2143   Protein   NP_588611   KIAA1966   KIAA1966 protein       2144   DNA   NM_015196   KIAA0922   KIAA0922 protein       2145   Protein   NP_056011   KIAA0922   KIAA0922 protein       2146   DNA   AI655015         Homo sapiens  mRNA; cDNA                       DKFZp586F2224 (from clone                       DKFZp586F2224), mRNA                       sequence       2147   DNA   NM_006190   ORC2L   origin recognition complex,                       subunit 2-like (yeast)       2148   Protein   NP_006181   ORC2L   origin recognition complex,                       subunit 2-like (yeast)       2149   DNA   NM_005227   EFNA4   ephrin-A4       2150   Protein   NP_005218   EFNA4   ephrin-A4       2151   DNA   NM_006714   ASM3A   acid sphingomyelinase-like                       phosphodiesterase       2152   Protein   NP_006705   ASM3A   acid sphingomyelinase-like                       phosphodiesterase       2153   DNA   AF150247       HSPC060 [ Homo sapiens ],                       mRNA sequence       2154   DNA   NM_003542   H4FG   H4 histone family, member G       2155   Protein   NP_003533   H4FG   H4 histone family, member G       2156   DNA   NM_006020   ALKBH   alkB, alkylation repair homolog                       ( E. coli )       2157   Protein   NP_006011   ALKBH   alkB, alkylation repair homolog                       ( E. coli )       2158   DNA   NM_014777   KIAA0133   KIAA0133 gene product       2159   Protein   NP_055592   KIAA0133   KIAA0133 gene product       2160   DNA   NM_006101   HEC   highly expressed in cancer, rich                       in leucine heptad repeats       2161   Protein   NP_006092   HEC   highly expressed in cancer, rich                       in leucine heptad repeats       2162   DNA   NM_005785   SBB103   hypothetical SBBI03 protein       2163   Protein   NP_005776   SBB103   hypothetical SBBI03 protein       2164   DNA   NM_014676   PUM1   pumilio homolog 1                       ( Drosophila )       2165   Protein   NP_055491   PUM1   pumilio homolog 1                       ( Drosophila )       2166   DNA   NM_002657   PLAGL2   pleiomorphic adenoma gene-                       like 2       2167   Protein   NP_002648   PLAGL2   pleiomorphic adenoma gene-                       like 2       2168   DNA   NM_005831   NDP52   nuclear domain 10 protein       2169   Protein   NP_005822   NDP52   nuclear domain 10 protein       2170   DNA   NM_003174   SVIL   supervillin       2171   Protein   NP_003165   SVIL   supeivillin       2172   DNA   NM_021738   SVIL   supervillin       2173   Protein   NP_068506   SVIL   supervillin       2174   DNA   NM_005676   RBM10   RNA binding motif protein 10       2175   Protein   NP_005667   RBM10   RNA binding motif protein 10       2176   DNA   NM_152856   RBM10   RNA binding motif protein 10       2177   Protein   NP_690595   RBM10   RNA binding motif protein 10       2178   DNA   NM_015046   KIAA0625   KIAA0625 protein       2179   Protein   NP_055861   KIAA0625   KIAA0625 protein       2180   DNA   D87450   KIAA0261   KIAA0261 protein       2181   Protein   D87450 (Translation)   KIAA0261   KIAA0261 protein       2182   DNA   NM_003489   NRIP1   nuclear receptor interacting                       protein 1       2183   Protein   NP_003480   NRIP1   nuclear receptor interacting                       protein 1       2184   DNA   NM_017528   WBSCR22   Williams Beuren syndrome                       chromosome region 22       2185   Protein   NP_059998   WBSCR22   Williams Beuren syndrome                       chromosome region 22       2186   DNA   NM_006795   EHD1   EH-domain containing 1       2187   Protein   NP_006786   EHD1   EH-domain containing 1       2188   DNA   NM_006374   STK25   serine/threonine kinase 25                       (STE20 homolog, yeast)       2189   Protein   NP_006365   STK25   serine/threonine kinase 25                       (STE20 homolog, yeast)       2190   DNA   NM_007040   E1B-AP5   E1B-55 kDa-associated protein 5       2191   Protein   NP_008971   E1B-AP5   E1B-55 kDa-associated protein 5       2192   DNA   NM_144732   E1B-AP5   E1B-55 kDa-associated protein 5       2193   Protein   NP_653333   E1B-AP5   E1B-55 kDa-associated protein 5       2194   DNA   NM_144733   E1B-AP5   E1B-55 kDa-associated protein 5       2195   Protein   NP_653334   E1B-AP5   E1B-55 kDa-associated protein 5       2196   DNA   NM_144734   E1B-AP5   E1B-55 kDa-associated protein 5       2197   Protein   NP_653335   E1B-AP5   E1B-55 kDa-associated protein 5       2198   DNA   NM_017715   ZNF3   zinc finger protein 3 (A8-51)       2199   Protein   NP_060185   ZNF3   zinc finger protein 3 (A8-51)       2200   DNA   NM_032924   ZNF3   zinc finger protein 3 (A8-51)       2201   Protein   NP_116313   ZNF3   zinc finger protein 3 (A8-51)       2202   DNA   NM_006371   CRTAP   cartilage associated protein       2203   Protein   NP_006362   CRTAP   cartilage associated protein       2204   DNA   NM_006372   NSAP1   NS1-associated protein 1       2205   Protein   NP_006363   NSAP1   NS1-associated protein 1       2206   DNA   NM_014666   ENTH   enthoprotin       2207   Protein   NP_055481   ENTH   enthoprotin       2208   DNA   NM_004889   ATP5J2   ATP synthase, H+ transporting,                       mitochondrial F0 complex,                       subunit f, isoform 2       2209   Protein   NP_004880   ATP5J2   ATP synthase, H+ transporting,                       mitochondrial F0 complex,                       subunit f, isoform 2       2210   DNA   NM_005667   ZFP103   zinc finger protein 103                       homolog (mouse)       2211   Protein   NP_005658   ZFP103   zinc finger protein 103                       homolog (mouse)       2212   DNA   NM_014661   KIAA0140   KIAA0140 gene product       2213   Protein   NP_055476   KIAA0140   KIAA0140 gene product       2214   DNA   NM_015646   RAP1B   RAP1B, member of RAS                       oncogene family       2215   Protein   NP_056461   RAP1B   RAP1B, member of RAS                       oncogene family       2216   DNA   NM_172020   POM121   POM121 membrane                       glycoprotein (rat)       2217   Protein   NP_742017   POM121   POM121 membrane                       glycoprotein (rat)       2218   DNA   NM_012083   FRAT2   frequently rearranged in                       advanced T-cell lymphomas 2       2219   Protein   NP_036215   FRAT2   frequently rearranged in                       advanced T-cell lymphomas 2       2220   DNA   NM_144635   MGC21688   hypothetical protein                       MGC21688       2221   Protein   NP_653236   MGC21688   hypothetical protein                       MGC21688       2222   DNA   NM_006510   RFP   ret finger protein       2223   Protein   NP_006501   RFP   ret finger protein       2224   DNA   NM_030950   RFP   ret finger protein       2225   Protein   NP_112212   RFP   ret finger protein       2226   DNA   AI761647         Homo sapiens  cDNA FLJ36527                       fis, clone TRACH2003941,                       mRNA sequence       2227   DNA   NM_002105   H2AFX   H2A histone family, member X       2228   Protein   NP_002096   H2AFX   H2A histone family, member X       2229   DNA   NM_005801   SUI1   putative translation initiation                       factor       2230   Protein   NP_005792   SUI1   putative translation initiation                       factor       2231   DNA   R37702       ESTs       2232   DNA   NM_003358   UGCG   UDP-glucose ceramide                       glucosyltransferase       2233   Protein   NP_003349   UGCG   UDP-glucose ceramide                       glucosyltransferase       2234   DNA   NM_006460   HIS1   HMBA-inducible       2235   Protein   NP_006451   HIS1   HMBA-inducible       2236   DNA   NM_018380   DDX28   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 28       2237   Protein   NP_060850   DDX28   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 28       2238   DNA   NM_001895   CSNK2A1   casein kinase 2, alpha 1                       polypeptide       2239   Protein   NP_001886   CSNK2A1   casein kinase 2, alpha 1                       polypeptide       2240   DNA   NM_003675   PRPF18   PRP18 pre-mRNA processing                       factor 18 homolog (yeast)       2241   Protein   NP_003666   PRPF18   PRP18 pre-mRNA processing                       factor 18 homolog (yeast)       2242   DNA   NM_001352   DBP   D site of albumin promoter                       (albumin D-box) binding                       protein       2243   Protein   NP_001343   DBP   D site of albumin promoter                       (albumin D-box) binding                       protein       2244   DNA   NM_020126   DBP   D site of albumin promoter                       (albumin D-box) binding                       protein       2245   Protein   NP_064511   DBP   D site of albumin promoter                       (albumin D-box) binding                       protein       2246   DNA   NM_004404   NEDD5   neural precursor cell expressed,                       developmentally down-                       regulated 5       2247   Protein   NP_004395   NEDD5   neural precursor cell expressed,                       developmentally down-                       regulated 5       2248   DNA   NM_002533   NVL   nuclear VCP-like       2249   Protein   NP_002524   NVL   nuclear VCP-like       2250   DNA   AI830496   KIAA1240   KIAA1240 protein       2251   DNA   NM_000474   TWIST   twist homolog                       (acrocephalosyndactyly 3;                       Saethre-Chotzen syndrome)                       ( Drosophila )       2252   Protein   NP_000465   TWIST   twist homolog                       (acrocephalosyndactyly 3;                       Saethre-Chotzen syndrome)                       ( Drosophila )       2253   DNA   NM_007346   OGFR   opioid growth factor receptor       2254   Protein   NP_031372   OGFR   opioid growth factor receptor       2255   DNA   NM_001202   BMP4   bone morphogenetic protein 4       2256   Protein   NP_001193   BMP4   bone morphogenetic protein 4       2257   DNA   NM_130850   BMP4   bone morphogenetic protein 4       2258   DNA   NM_130851   BMP4   bone morphogenetic protein 4       2259   DNA   NM_015421   DKFZP564K2062   DKFZP564K2062 protein       2260   Protein   NP_056236   DKFZP564K2062   DKFZP564K2062 protein       2261   DNA   NM_005924   MEOX2   mesenchyme homeo box 2                       (growth arrest-specific homeo                       box)       2262   Protein   NP_005915   MEOX2   mesenchyme homeo box 2                       (growth arrest-specific homeo                       box)       2263   DNA   NM_014071   NCOA6   nuclear receptor coactivator 6       2264   Protein   NP_054790   NCOA6   nuclear receptor coactivator 6       2265   DNA   NM_015252   KIAA0903   KIAA0903 protein       2266   Protein   NP_056067   KIAA0903   KIAA0903 protein       2267   DNA   NM_001707   BCL7B   B-cell CLL/lymphoma 7B       2268   Protein   NP_001698   BCL7B   B-cell CLL/lymphoma 7B       2269   DNA   NM_138707   BCL7B   B-cell CLL/lymphoma 7B       2270   Protein   NP_619713   BCL7B   B-cell CLL/lymphoma 7B       2271   DNA   NM_015251   KIAA0431   KIAA0431 protein       2272   Protein   NP_056066   KIAA0431   KIAA0431 protein       2273   DNA   NM_015497   DKFZP564G2022   DKFZP564G2022 protein       2274   Protein   NP_056312   DKFZP564G2022   DKFZP564G2022 protein       2275   DNA   NM_002480   PPP1R12A   protein phosphatase 1,                       regulatory (inhibitor) subunit                       12A       2276   Protein   NP_002471   PPP1R12A   protein phosphatase 1,                       regulatory (inhibitor) subunit                       12A       2277   DNA   NM_004514   ILF1   interleukin enhancer binding                       factor 1       2278   Protein   NP_004505   ILF1   interleukin enhancer binding                       factor 1       2279   DNA   AB020633   KIAA0826   KIAA0826 protein       2280   Protein   AB020633   KIAA0826   KIAA0826 protein               (Translation)       2281   DNA   NM_020465   NDRG4   NDRG family member 4       2282   Protein   NP_065198   NDRG4   NDRG family member 4       2283   DNA   NM_022910   NDRG4   NDRG family member 4       2284   DNA   NM_015966   SDBCAG84   serologically defined breast                       cancer antigen 84       2285   Protein   NP_057050   SDBCAG84   serologically defined breast                       cancer antigen 84       2286   DNA   NM_007198   PROSC   proline synthetase co-                       transcribed homolog (bacterial)       2287   Protein   NP_009129   PROSC   proline synthetase co-                       transcribed homolog (bacterial)       2288   DNA   NM_004935   CDK5   cyclin-dependent kinase 5       2289   Protein   NP_004926   CDK5   cyclin-dependent kinase 5       2290   DNA   AL049987         Homo sapiens  mRNA; cDNA                       DKFZp564F112 (from clone                       DKFZp564F112), mRNA                       sequence       2291   DNA   NM_005994   TBX2   T-box 2       2292   Protein   NP_005985   TBX2   T-box 2       2293   DNA   AL050007   DKFZP564A043   DKFZP564A043 protein       2294   Protein   AL050007   DKFZP564A043   DKFZP564A043 protein               (Translation)       2295   DNA   NM_007172   NUP50   nucleoporin 50 kDa       2296   Protein   NP_009103   NUP50   nucleoporin 50 kDa       2297   DNA   NM_153645   NUP50   nucleoporin 50 kDa       2298   Protein   NP_705931   NUP50   nucleoporin 50 kDa       2299   DNA   NM_153684   NUP50   nucleoporin 50 kDa       2300   DNA   NM_002824   PTMS   parathymosin       2301   Protein   NP_002815   PTMS   parathymosin       2302   DNA   AF052178         Homo sapiens  clone 24523                       mRNA sequence       2303   DNA   NM_003583   DYRK2   dual-specificity tyrosine-(Y)-                       phosphorylation regulated                       kinase 2       2304   Protein   NP_003574   DYRK2   dual-specificity tyrosine-(Y)-                       phosphorylation regulated                       kinase 2       2305   DNA   NM_006482   DYRK2   dual-specificity tyrosine-(Y)-                       phosphorylation regulated                       kinase 2       2306   Protein   NP_006473   DYRK2   dual-specificity tyrosine-(Y)-                       phosphorylation regulated                       kinase 2       2307   DNA   AI475497   HELSNF1   helicase with SNF2 domain 1       2308   DNA   NM_016107   ZFR   zinc finger RNA binding                       protein       2309   Protein   NP_057191   ZFR   zinc finger RNA binding                       protein       2310   DNA   NM_025137   FLJ21439   hypothetical protein FLJ21439       2311   Protein   NP_079413   FLJ21439   hypothetical protein FLJ21439       2312   DNA   NM_017736   FLJ20274   hypothetical protein FLJ20274       2313   Protein   NP_060206   FLJ20274   hypothetical protein FLJ20274       2314   DNA   NM_017548   H41   hypothetical protein H41       2315   Protein   NP_060018   H41   hypothetical protein H41       2316   DNA   NM_005749   TOB1   transducer of ERBB2, 1       2317   Protein   NP_005740   TOB1   transducer of ERBB2, 1       2318   DNA   NM_005803   FLOT1   flotillin 1       2319   Protein   NP_005794   FLOT1   flotillin 1       2320   DNA   NM_005138   SCO2   SCO cytochrome oxidase                       deficient homolog 2 (yeast)       2321   Protein   NP_005129   SCO2   SCO cytochrome oxidase                       deficient homolog 2 (yeast)       2322   DNA   AI312646         Homo sapiens  mRNA; cDNA                       DKFZp564H1916 (from clone                       DKFZp564H1916), mRNA                       sequence       2323   DNA   NM_003937   KYNU   kynureninase (L-kynurenine                       hydrolase)       2324   Protein   NP_003928   KYNU   kynureninase (L-kynurenine                       hydrolase)       2325   DNA   NM_001827   CKS2   CDC28 protein kinase                       regulatory subunit 2       2326   Protein   NP_001818   CKS2   CDC28 protein kinase                       regulatory subunit 2       2327   DNA   NM_016324   ZNF274   zinc finger protein 274       2328   Protein   NP_057408   ZNF274   zinc finger protein 274       2329   DNA   NM_016325   ZNF274   zinc finger protein 274       2330   Protein   NP_057409   ZNF274   zinc finger protein 274       2331   DNA   NM_133502   ZNF274   zinc finger protein 274       2332   Protein   NP_598009   ZNF274   zinc finger protein 274       2333   DNA   NM_004523   KNSL1   kinesin-like 1       2334   Protein   NP_004514   KNSL1   kinesin-like 1       2335   DNA   NM_014885   APC10   anaphase-promoting complex                       subunit 10       2336   Protein   NP_055700   APC10   anaphase-promoting complex                       subunit 10       2337   DNA   NM_002519   NPAT   nuclear protein, ataxia-                       telangiectasia locus       2338   Protein   NP_002510   NPAT   nuclear protein, ataxia-                       telangiectasia locus       2339   DNA   NM_002449   MSX2   msh homeo box homolog 2                       ( Drosophila )       2340   Protein   NP_002440   MSX2   msh homeo box homolog 2                       ( Drosophila )       2341   DNA   NM_002398   MEIS1   Meis1, myeloid ecotropic viral                       integration site 1 homolog                       (mouse)       2342   Protein   NP_002389   MEIS1   Meis1, myeloid ecotropic viral                       integration site 1 homolog                       (mouse)       2343   DNA   NM_005085   NUP214   nucleoporin 214 kDa       2344   Protein   NP_005076   NUP214   nucleoporin 214 kDa       2345   DNA   NM_153642   NUP214   nucleoporin 214 kDa       2346   Protein   NP_705906   NUP214   nucleoporin 214 kDa       2347   DNA   NM_004493   HADH2   hydroxyacyl-Coenzyme A                       dehydrogenase, type II       2348   Protein   NP_004484   HADH2   hydroxyacyl-Coenzyme A                       dehydrogenase, type II       2349   DNA   NM_001329   CTBP2   C-terminal binding protein 2       2350   Protein   NP_001320   CTBP2   C-terminal binding protein 2       2351   DNA   NM_022802   CTBP2   C-terminal binding protein 2       2352   Protein   NP_073713   CTBP2   C-terminal binding protein 2       2353   DNA   NM_133264   WIRE   WIRE protein       2354   Protein   NP_573571   WIRE   WIRE protein       2355   DNA   NM_000937   POLR2A   polymerase (RNA) II (DNA                       directed) polypeptide A,                       220 kDa       2356   Protein   NP_000928   POLR2A   polymerase (RNA) II (DNA                       directed) polypeptide A,                       220 kDa       2357   DNA   AA643063   DKFZP434C212   DKFZP434C212 protein       2358   DNA   NM_001275   CHGA   chromogranin A (parathyroid                       secretory protein 1)       2359   Protein   NP_001266   CHGA   chromogranin A (parathyroid                       secretory protein 1)       2360   DNA   NM_015555   COASTER   coactivator for steroid receptors       2361   Protein   NP_056370   COASTER   coactivator for steroid receptors       2362   DNA   NM_015874   KBF2   H-2K binding factor-2       2363   Protein   NP_056958   KBF2   H-2K binding factor-2       2364   DNA   NM_000687   AHCY   S-adenosylhomocysteine                       hydrolase       2365   Protein   NP_000678   AHCY   S-adenosylhomocysteine                       hydrolase       2366   DNA   NM_002376   MARK3   MAP/microtubule affinity-                       regulating kinase 3       2367   Protein   NP_002367   MARK3   MAP/microtubule affinity-                       regulating kinase 3       2368   DNA   NM_003899   ARHGEF7   Rho guanine nucleotide                       exchange factor (GEF) 7       2369   Protein   NP_003890   ARHGEF7   Rho guanine nucleotide                       exchange factor (GEF) 7       2370   DNA   NM_145735   ARHGEF7   Rho guanine nucleotide                       exchange factor (GEF) 7       2371   Protein   NP_663788   ARHGEF7   Rho guanine nucleotide                       exchange factor (GEF) 7       2372   DNA   NM_015634   DKFZP586B0923   DKFZP586B0923 protein       2373   Protein   NP_056449   DKFZP586B0923   DKFZP586B0923 protein       2374   DNA   AB011102   ZNF292   zinc finger protein 292       2375   Protein   AB011102   ZNF292   zinc finger protein 292               (Translation)       2376   DNA   NM_024824   FLJ11806   hypothetical protein FLJ11806       2377   Protein   NP_079100   FLJ11806   hypothetical protein FLJ11806       2378   DNA   NM_001823   CKB   creatine kinase, brain       2379   Protein   NP_001814   CKB   creatine kinase, brain       2380   DNA   NM_003211   TDG   thymine-DNA glycosylase       2381   Protein   NP_003202   TDG   thymine-DNA glycosylase       2382   DNA   NM_003634   NIPSNAP1   nipsnap homolog 1 ( C. elegans )       2383   Protein   NP_003625   NIPSNAP1   nipsnap homolog 1 ( C. elegans )       2384   DNA   NM_014225   PPP2R1A   protein phosphatase 2 (formerly                       2A), regulatory subunit A (PR                       65), alpha isoform       2385   Protein   NP_055040   PPP2R1A   protein phosphatase 2 (formerly                       2A), regulatory subunit A (PR                       65), alpha isoform       2386   DNA   T57872       EST, Moderately similar to                       COXG_HUMAN Cytochrome                       c oxidase polypeptide VIb                       (AED) [ H. sapiens ]       2387   DNA   NM_003792   EDF1   endothelial differentiation-                       related factor 1       2388   Protein   NP_003783   EDF1   endothelial differentiation-                       related factor 1       2389   DNA   NM_153200   EDF1   endothelial differentiation-                       related factor 1       2390   Protein   NP_694880   EDF1   endothelial differentiation-                       related factor 1       2391   DNA   NM_004332   BPHL   biphenyl hydrolase-like (serine                       hydrolase; breast epithelial                       mucin-associated antigen)       2392   Protein   NP_004323   BPHL   biphenyl hydrolase-like (serine                       hydrolase; breast epithelial                       mucin-associated antigen)       2393   DNA   AA290994         Homo sapiens  cDNA FLJ20722                       fis, clone HEP15411, mRNA                       sequence       2394   DNA   AA554945       ESTs, Weakly similar to                       hypothetical protein FLJ20378                       [ Homo sapiens ] [ H. sapiens ]       2395   DNA   NM_015626   WSB1   SOCS box-containing WD                       protein SWiP-1       2396   Protein   NP_056441   WSB1   SOCS box-containing WD                       protein SWiP-1       2397   DNA   NM_134264   WSB1   SOCS box-containing WD                       protein SWiP-1       2398   Protein   NP_599026   WSB1   SOCS box-containing WD                       protein SWiP-1       2399   DNA   NM_134265   WSB1   SOCS box-containing WD                       protein SWiP-1       2400   Protein   NP_599027   WSB1   SOCS box-containing WD                       protein SWiP-1       2401   DNA   NM_030980   FLJ12671   hypothetical protein FLJ12671       2402   Protein   NP_112242   FLJ12671   hypothetical protein FLJ12671       2403   DNA   NM_017432   PTOV1   prostate tumor over expressed                       gene 1       2404   Protein   NP_059128   PTOV1   prostate tumor over expressed                       gene 1       2405   DNA   W26477   HELSNF1   helicase with SNF2 domain 1       2406   DNA   NM_003864   SAP30   sin3-associated polypeptide,                       30 kDa       2407   Protein   NP_003855   SAP30   sin3-associated polypeptide,                       30 kDa       2408   DNA   L36531   ITGA8   integrin alpha 8       2409   Protein   L36531 (Translation)   ITGA8   integrin, alpha 8       2410   DNA   NM_004272   SYN47   Homer, neuronal immediate                       early gene, 1B       2411   Protein   NP_004263   SYN47   Homer, neuronal immediate                       early gene, 1B       2412   DNA   NM_003213   TEAD4   TEA domain family member 4       2413   Protein   NP_003204   TEAD4   TEA domain family member 4       2414   DNA   NM_024112   C9orf16   chromosome 9 open reading                       frame 16       2415   Protein   NP_077017   C9orf16   chromosome 9 open reading                       frame 16       2416   DNA   NM_005544   IRS1   insulin receptor substrate 1       2417   Protein   NP_005535   IRS1   insulin receptor substrate 1       2418   DNA   NM_006951   TAF5   TAF5 RNA polymerase II,                       TATA box binding protein                       (TBP)-associated factor,                       100 kDa       2419   Protein   NP_008882   TAF5   TAF5 RNA polymerase II,                       TATA box binding protein                       (TBP)-associated factor,                       100 kDa       2420   DNA   NM_139052   TAF5   TAF5 RNA polymerase II,                       TATA box binding protein                       (TBP)-associated factor,                       100 kDa       2421   Protein   NP_620640   TAF5   TAF5 RNA polymerase II,                       TATA box binding protein                       (TBP)-associated factor,                       100 kDa       2422   DNA   NM_002692   POLE2   polymerase (DNA directed),                       epsilon 2 (p59 subunit)       2423   Protein   NP_002683   POLE2   polymerase (DNA directed),                       epsilon 2 (p59 subunit)       2424   DNA   NM_004459   FALZ   fetal Alzheimer antigen       2425   Protein   NP_004450   FALZ   fetal Alzheimer antigen       2426   DNA   NM_004634   BRPF1   bromodomain and PHD finger                       containing, 1       2427   Protein   NP_004625   BRPF1   bromodomain and PHD finger                       containing, 1       2428   DNA   NM_003624   RANBP3   RAN binding protein 3       2429   Protein   NP_003615   RANBP3   RAN binding protein 3       2430   DNA   NM_007320   RANBP3   RAN binding protein 3       2431   Protein   NP_015559   RANBP3   RAN binding protein 3       2432   DNA   NM_007321   RANBP3   RAN binding protein 3       2433   Protein   NP_015560   RANBP3   RAN binding protein 3       2434   DNA   NM_007322   RANBP3   RAN binding protein 3       2435   Protein   NP_015561   RANBP3   RAN binding protein 3       2436   DNA   NM_014902   KIAA0964   KIAA0964 protein       2437   Protein   NP_055717   KIAA0964   KIAA0964 protein       2438   DNA   NM_002414   MIC2   antigen identified by                       monoclonal antibodies 12E7,                       F21 and O13       2439   Protein   NP_002405   MIC2   antigen identified by                       monoclonal antibodies 12E7,                       F21 and O13       2440   DNA   NM_005534   IFNGR2   interferon gamma receptor 2                       (interferon gamma transducer                       1)       2441   Protein   NP_005525   IFNGR2   interferon gamma receptor 2                       (interferon gamma transducer                       1)       2442   DNA   NM_014827   KIAA0663   KIAA0663 gene product       2443   Protein   NP_055642   KIAA0663   KIAA0663 gene product       2444   DNA   NM_005054   RANBP2L1   RAN binding protein 2-like 1       2445   Protein   NP_005045   RANBP2L1   RAN binding protein 2-like 1       2446   DNA   NM_032260   RANBP2L1   RAN binding protein 2-like 1       2447   Protein   NP_115636   RANBP2L1   RAN binding protein 2-like 1       2448   DNA   NM_000975   RPL11   ribosomal protein L11       2449   Protein   NP_000966   RPL11   ribosomal protein L11       2450   DNA   NM_005730   OS4   conserved gene amplified in                       osteosarcoma       2451   Protein   NP_005721   OS4   conserved gene amplified in                       osteosarcoma       2452   DNA   NM_000462   UBE3A   ubiquitin protein ligase E3A                       (human papilloma virus E6-                       associated protein, Angelman                       syndrome)       2453   Protein   NP_000453   UBE3A   ubiquitin protein ligase E3A                       (human papilloma virus E6-                       associated protein, Angelman                       syndrome)       2454   DNA   NM_130838   UBE3A   ubiquitin protein ligase E3A                       (human papilloma virus E6-                       associated protein, Angelman                       syndrome)       2455   Protein   NP_570853   UBE3A   ubiquitin protein ligase E3A                       (human papilloma virus E6-                       associated protein, Angelman                       syndrome)       2456   DNA   NM_130839   UBE3A   ubiquitin protein ligase E3A                       (human papilloma virus E6-                       associated protein, Angelman                       syndrome)       2457   Protein   NP_570854   UBE3A   ubiquitin protein ligase E3A                       (human papilloma virus E6-                       associated protein, Angelman                       syndrome)       2458   DNA   NM_004373   COX6A1   cytochrome c oxidase subunit                       VIa polypeptide 1       2459   Protein   NP_004364   COX6A1   cytochrome c oxidase subunit                       VIa polypeptide 1       2460   DNA   NM_022170   WBSCR1   Williams-Beuren syndrome                       chromosome region 1       2461   Protein   NP_071496   WBSCR1   Williams-Beuren syndrome                       chromosome region 1       2462   DNA   NM_031992   WBSCR1   Williams-Beuren syndrome                       chromosome region 1       2463   Protein   NP_114381   WBSCR1   Williams-Beuren syndrome                       chromosome region 1       2464   DNA   NM_002574   PRDX1   peroxiredoxin 1       2465   Protein   NP_002565   PRDX1   peroxiredoxin 1       2466   DNA   NM_002166   ID2   inhibitor of DNA binding 2,                       dominant negative helix-loop-                       helix protein       2467   Protein   NP_002157   ID2   inhibitor of DNA binding 2,                       dominant negative helix-loop-                       helix protein       2468   DNA   NM_002629   PGAM1   phosphoglycerate mutase 1                       (brain)       2469   Protein   NP_002620   PGAM1   phosphoglycerate mutase 1                       (brain)       2470   DNA   NM_004090   DUSP3   dual specificity phosphatase 3                       (vaccinia virus phosphatase                       VH1-related)       2471   Protein   NP_004081   DUSP3   dual specificity phosphatase 3                       (vaccinia virus phosphatase                       VH1-related)       2472   DNA   AI222594         Homo sapiens  mRNA; cDNA                       DKFZp564H1916 (from clone                       DKFZp564H1916), mRNA                       sequence       2473   DNA   NM_013298   HSU79252   hypothetical protein HSU79252       2474   Protein   NP_037430   HSU79252   hypothetical protein HSU79252       2475   DNA   AB007916   KIAA0447   KIAA0447 gene product       2476   Protein   AB007916   KIAA0447   KIAA0447 gene product               (Translation)       2477   DNA   NM_006303   JTV1   JTV1 gene       2478   Protein   NP_006294   JTV1   JTV1 gene       2479   DNA   NM_004773   TRIP3   thyroid hormone receptor                       interactor 3       2480   Protein   NP_004764   TRIP3   thyroid hormone receptor                       interactor 3       2481   DNA   NM_016391   HSPC111   hypothetical protein HSPC111       2482   Protein   NP_057475   HSPC111   hypothetical protein HSPC111       2483   DNA   AL046940       ESTs, Weakly similar to                       hypothetical protein FLJ22184                       [ Homo sapiens ] [ H. sapiens ]       2484   DNA   NM_020151   STARD7   START domain containing 7       2485   Protein   NP_064536   STARD7   START domain containing 7       2486   DNA   NM_139267   STARD7   START domain containing 7       2487   DNA   NM_005234   NR2F6   nuclear receptor subfamily 2,                       group F, member 6       2488   Protein   NP_005225   NR2F6   nuclear receptor subfamily 2,                       group F, member 6       2489   DNA   NM_002967   SAFB   scaffold attachment factor B       2490   Protein   NP_002958   SAFB   scaffold attachment factor B       2491   DNA   NM_018186   PACE-1   ezrin-binding partner PACE-1       2492   Protein   NP_060656   PACE-1   ezrin-binding partner PACE-1       2493   DNA   NM_020423   PACE-1   ezrin-binding partner PACE-1       2494   Protein   NP_065156   PACE-1   ezrin-binding partner PACE-1       2495   DNA   NM_001130   AES   amino-terminal enhancer of                       split       2496   Protein   NP_001121   AES   amino-terminal enhancer of                       split       2497   DNA   NM_005859   PURA   purine-rich element binding                       protein A       2498   Protein   NP_005850   PURA   purine-rich element binding                       protein A       2499   DNA   NM_003032   SIAT1   sialyltransferase 1 (beta-                       galactoside alpha-2,6-                       sialytransferase)       2500   Protein   NP_003023   SIAT1   sialyltransferase 1 (beta-                       galactoside alpha-2,6-                       sialytransferase)       2501   DNA   NM_173216   SIAT1   sialyltransferase 1 (beta-                       galactoside alpha-2,6-                       sialytransferase)       2502   DNA   NM_173217   SIAT1   sialyltransferase 1 (beta-                       galactoside alpha-2,6-                       sialytransferase)       2503   Protein   NP_775324   SIAT1   sialyltransferase 1 (beta-                       galactoside alpha-2,6-                       sialytransferase)       2504   DNA   NM_003952   RPS6KB2   ribosomal protein S6 kinase,                       70 kDa, polypeptide 2       2505   Protein   NP_003943   RPS6KB2   ribosomal protein S6 kinase,                       70 kDa, polypeptide 2       2506   DNA   NM_015110   SMC5   SMC5 protein       2507   Protein   NP_055925   SMC5   SMC5 protein       2508   DNA   NM_007152   ZNF195   zinc finger protein 195       2509   Protein   NP_009083   ZNF195   zinc finger protein 195       2510   DNA   NM_003171   SUPV3L1   suppressor of var1, 3-like 1 ( S. cerevisiae )       2511   Protein   NP_003162   SUPV3L1   suppressor of var1, 3-like 1 ( S. cerevisiae )       2512   DNA   NM_012265   C22orf3   chromosome 22 open reading                       frame 3       2513   Protein   NP_036397   C22orf3   chromosome 22 open reading                       frame 3       2514   DNA   NM_004053   BYSL   bystin-like       2515   Protein   NP_004044   BYSL   bystin-like       2516   DNA   NM_014921   LEC2   lectomedin-2       2517   Protein   NP_055736   LEC2   lectomedin-2       2518   DNA   NM_015285   WDR7   WD repeat domain 7       2519   Protein   NP_056100   WDR7   WD repeat domain 7       2520   DNA   NM_052834   WDR7   WD repeat domain 7       2521   Protein   NP_443066   WDR7   WD repeat domain 7       2522   DNA   AB014554   PPFIA3   protein tyrosine phosphatase,                       receptor type, f polypeptide                       (PTPRF), interacting protein                       (liprin), alpha 3       2523   Protein   AB014554   PPFIA3   protein tyrosine phosphatase,               (Translation)       receptor type, f polypeptide                       (PTPRF), interacting protein                       (liprin), alpha 3       2524   DNA   NM_003453   ZNF198   zinc finger protein 198       2525   Protein   NP_003444   ZNF198   zinc finger protein 198       2526   DNA   NM_005043   MAP2K7   mitogen-activated protein                       kinase kinase 7       2527   Protein   NP_005034   MAP2K7   mitogen-activated protein                       kinase kinase 7       2528   DNA   NM_145185   MAP2K7   mitogen-activated protein                       kinase kinase 7       2529   Protein   NP_660186   MAP2K7   mitogen-activated protein                       kinase kinase 7       2530   DNA   NM_145329   MAP2K7   mitogen-activated protein                       kinase kinase 7       2531   Protein   NP_663302   MAP2K7   mitogen-activated protein                       kinase kinase 7       2532   DNA   NM_014918   CHSY1   carbohydrate (chondroitin)                       synthase 1       2533   Protein   NP_055733   CHSY1   carbohydrate (chondroitin)                       synthase 1       2534   DNA   AB007883   KIAA0423   KIAA0423 protein       2535   Protein   AB007883   KIAA0423   KIAA0423 protein               (Translation)       2536   DNA   NM_004520   KIF2   kinesin heavy chain member 2       2537   Protein   NP_004511   KIF2   kinesin heavy chain member 2       2538   DNA   NM_021212   ZF   HCF-binding transcription                       factor Zhangfei       2539   Protein   NP_067035   ZF   HCF-binding transcription                       factor Zhangfei       2540   DNA   NM_005360   MAF   v-maf musculoaponeurotic                       fibrosarcoma oncogene                       homolog (avian)       2541   Protein   NP_005351   MAF   v-maf musculoaponeurotic                       fibrosarcoma oncogene                       homolog (avian)       2542   DNA   NM_003668   MAPKAPK5   mitogen-activated protein                       kinase-activated protein kinase 5       2543   Protein   NP_003659   MAPKAPK5   mitogen-activated protein                       kinase-activated protein kinase 5       2544   DNA   NM_139078   MAPKAPK5   mitogen-activated protein                       kinase-activated protein kinase 5       2545   Protein   NP_620777   MAPKAPK5   mitogen-activated protein                       kinase-activated protein kinase 5       2546   DNA   NM_002405   MFNG   manic fringe homolog                       ( Drosophila )       2547   Protein   NP_002396   MFNG   manic fringe homolog                       ( Drosophila )       2548   DNA   NM_006339   HMG20B   high-mobility group 20B       2549   Protein   NP_006330   HMG20B   high-mobility group 20B       2550   DNA   W72239         Homo sapiens  mRNA; cDNA                       DKFZp434M162 (from clone                       DKFZp434M162), mRNA                       sequence       2551   DNA   NM_000835   GRIN2C   glutamate receptor, ionotropic,                       N-methyl D-asparate 2C       2552   Protein   NP_000826   GRIN2C   glutamate receptor, ionotropic,                       N-methyl D-asparate 2C       2553   DNA   NM_006007   ZNF216   zinc finger protein 216       2554   Protein   NP_005998   ZNF216   zinc finger protein 216       2555   DNA   NM_004725   BUB3   BUB3 budding uninhibited by                       benzimidazoles 3 homolog                       (yeast)       2556   Protein   NP_004716   BUB3   BUB3 budding uninhibited by                       benzimidazoles 3 homolog                       (yeast)       2557   DNA   NM_015360   KIAA0052   KIAA0052 protein       2558   Protein   NP_056175   KIAA0052   KIAA0052 protein       2559   DNA   NM_005180   BMI1   B lymphoma Mo-MLV                       insertion region (mouse)       2560   Protein   NP_005171   BMI1   B lymphoma Mo-MLV                       insertion region (mouse)       2561   DNA   NM_015190   DNAJC9   DnaJ (Hsp40) homolog,                       subfamily C, member 9       2562   Protein   NP_056005   DNAJC9   DnaJ (Hsp40) homolog,                       subfamily C, member 9       2563   DNA   X68560   SP3   Sp3 transcription factor       2564   Protein   X68560 (Translation)   SP3   Sp3 transcription factor       2565   DNA   NM_004111   FEN1   flap structure-specific                       endonuclease 1       2566   Protein   NP_004102   FEN1   flap structure-specific                       endonuclease 1       2567   DNA   NM_016030   CGI-87   CGI-87 protein       2568   Protein   NP_057114   CGI-87   CGI-87 protein       2569   DNA   AB023164   KIAA0947   KIAA0947 protein       2570   Protein   AB023164   KIAA0947   KIAA0947 protein               (Translation)       2571   DNA   NM_001949   E2F3   E2F transcription factor 3       2572   Protein   NP_001940   E2F3   E2F transcription factor 3       2573   DNA   D87445   KIAA0256   KIAA0256 gene product       2574   Protein   D87445 (Translation)   KIAA0256   KIAA0256 gene product       2575   DNA   NM_015342   KIAA0073   KIAA0073 protein       2576   Protein   NP_056157   KIAA0073   KIAA0073 protein       2577   DNA   NM_018416   FHX   FOXJ2 forkhead factor       2578   Protein   NP_060886   FHX   FOXJ2 forkhead factor       2579   DNA   AB028956   KIAA1033   KIAA1033 protein       2580   Protein   AB028956   KIAA1033   KIAA1033 protein               (Translation)       2581   DNA   NM_004808   NMT2   N-myristoyltransferase 2       2582   Protein   NP_004799   NMT2   N-myristoyltransferase 2       2583   DNA   NM_000455   STK11   serine/threonine kinase 11                       (Peutz-Jeghers syndrome)       2584   Protein   NP_000446   STK11   serine/threonine kinase 11                       (Peutz-Jeghers syndrome)       2585   DNA   D83776   KIAA0191   KIAA0191 protein       2586   Protein   D83776 (Translation)   KIAA0191   KIAA0191 protein       2587   DNA   AF007128         Homo sapiens  clone 23870                       mRNA sequence       2588   DNA   AB018337   KIAA0794   KIAA0794 protein       2589   Protein   AB018337   KIAA0794   KIAA0794 protein               (Translation)       2590   DNA   NM_024051   MGC3077   hypothetical protein MGC3077       2591   Protein   NP_076956   MGC3077   hypothetical protein MGC3077       2592   DNA   NM_002646   PIK3C2B   phosphoinositide-3-kinase,                       class 2, beta polypeptide       2593   Protein   NP_002637   PIK3C2B   phosphoinositide-3-kinase,                       class 2, beta polypeptide       2594   DNA   NM_005745   BCAP31   accessory protein BAP31       2595   Protein   NP_005736   BCAP31   accessory protein BAP31       2596   DNA   NM_001319   CSNK1G2   casein kinase 1, gamma 2       2597   Protein   NP_001310   CSNK1G2   casein kinase 1, gamma 2       2598   DNA   NM_005744   ARIH1   ariadne homolog, ubiquitin-                       conjugating enzyme E2 binding                       protein, 1 ( Drosophila )       2599   Protein   NP_005735   ARIH1   ariadne homolog, ubiquitin-                       conjugating enzyme E2 binding                       protein, 1 ( Drosophila )       2600   DNA   NM_005839   SRRM1   serine/arginine repetitive matrix 1       2601   Protein   NP_005830   SRRM1   serine/arginine repetitive matrix 1       2602   DNA   NM_004342   CALD1   caldesmon 1       2603   Protein   NP_004333   CALD1   caldesmon 1       2604   DNA   NM_033138   CALD1   caldesmon 1       2605   Protein   NP_149129   CALD1   caldesmon 1       2606   DNA   NM_033139   CALD1   caldesmon 1       2607   Protein   NP_149130   CALD1   caldesmon 1       2608   DNA   NM_033140   CALD1   caldesmon 1       2609   Protein   NP_149131   CALD1   caldesmon 1       2610   DNA   NM_033157   CALD1   caldesmon 1       2611   Protein   NP_149347   CALD1   caldesmon 1       2612   DNA   NM_021034   IFITM3   interferon induced                       transmembrane protein 3 (1-8 U)       2613   Protein   NP_066362   IFITM3   interferon induced                       transmembrane protein 3 (1-8 U)       2614   DNA   NM_014900   KIAA0977   KIAA0977 protein       2615   Protein   NP_055715   KIAA0977   KIAA0977 protein       2616   DNA   NM_001865       Cluster Incl.                       AA978033: oq55e04.s1  Homo                           sapiens  cDNA, 3′ end                       /clone = IMAGE-1590270                       /clone_end = 3′ /gb = AA978033                       /gi = 3155479 /ug = Hs.182684                       /len = 524       2617   Protein   NP_001856       Cluster Incl.                       AA978033: oq55e04.s1  Homo                           sapiens  cDNA, 3′ end                       /clone = IMAGE-1590270                       /clone_end = 3′ /gb = AA978033                       /gi = 3155479 /ug = Hs.182684                       /len = 524       2618   DNA   NM_003252   TIAL1   TIA1 cytotoxic granule-                       associated RNA binding                       protein-like 1       2619   Protein   NP_003243   TIAL1   TIA1 cytotoxic granule-                       associated RNA binding                       protein-like 1       2620   DNA   NM_022333   TIAL1   TIA1 cytotoxic granule-                       associated RNA binding                       protein-like 1       2621   Protein   NP_071728   TIAL1   TIA1 cytotoxic granule-                       associated RNA binding                       protein-like 1       2622   DNA   NM_007209   RPL35   ribosomal protein L35       2623   Protein   NP_009140   RPL35   ribosomal protein L35       2624   DNA   NM_004045   ATOX1   ATX1 antioxidant protein 1                       homolog (yeast)       2625   Protein   NP_004036   ATOX1   ATX1 antioxidant protein 1                       homolog (yeast)       2626   DNA   NM_001418   EIF4G2   eukaryotic translation initiation                       factor 4 gamma, 2       2627   Protein   NP_001409   EIF4G2   eukaryotic translation initiation                       factor 4 gamma, 2       2628   DNA   NM_000352   ABCC8   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 8       2629   Protein   NP_000343   ABCC8   ATP-binding cassette, sub-                       family C (CFTR/MRP),                       member 8       2630   DNA   NM_006153   NCK1   NCK adaptor protein 1       2631   Protein   NP_006144   NCK1   NCK adaptor protein 1       2632   DNA   NM_002417   MKI67   antigen identified by                       monoclonal antibody Ki-67       2633   Protein   NP_002408   MKI67   antigen identified by                       monoclonal antibody Ki-67       2634   DNA   AL040137       ESTs       2635   DNA   NM_021145   DMTF1   cyclin D binding myb-like                       transcription factor 1       2636   Protein   NP_066968   DMTF1   cyclin D binding myb-like                       transcription factor 1       2637   DNA   NM_004602   STAU   staufen, RNA binding protein                       ( Drosophila )       2638   Protein   NP_004593   STAU   staufen, RNA binding protein                       ( Drosophila )       2639   DNA   NM_017452   STAU   staufen, RNA binding protein                       ( Drosophila )       2640   DNA   NM_017453   STAU   staufen, RNA binding protein                       ( Drosophila )       2641   Protein   NP_059347   STAU   staufen, RNA binding protein                       ( Drosophila )       2642   DNA   NM_017454   STAU   staufen, RNA binding protein                       ( Drosophila )       2643   DNA   NM_016001   CGI-48   CGI-48 protein       2644   Protein   NP_057085   CGI-48   CGI-48 protein       2645   DNA   AF052138         Homo sapiens  clone 23718                       mRNA sequence       2646   DNA   NM_002767   PRPSAP2   phosphoribosyl pyrophosphate                       synthetase-associated protein 2       2647   Protein   NP_002758   PRPSAP2   phosphoribosyl pyrophosphate                       synthetase-associated protein 2       2648   DNA   NM_015658   DKFZP564C186   DKFZP564C186 protein       2649   Protein   NP_056473   DKFZP564C186   DKFZP564C186 protein       2650   DNA   D29954   KIAA0056   KIAA0056 protein       2651   Protein   D29954 (Translation)   KIAA0056   KIAA0056 protein       2652   DNA   NM_000529   MC2R   melanocortin 2 receptor                       (adrenocorticotropic hormone)       2653   Protein   NP_000520   MC2R   melanocortin 2 receptor                       (adrenocorticotropic hormone)       2654   DNA   NM_002382   MAX   MAX protein       2655   Protein   NP_002373   MAX   MAX protein       2656   DNA   NM_145112   MAX   MAX protein       2657   Protein   NP_660087   MAX   MAX protein       2658   DNA   NM_145113   MAX   MAX protein       2659   DNA   NM_145114   MAX   MAX protein       2660   Protein   NP_660089   MAX   MAX protein       2661   DNA   NM_145116   MAX   MAX protein       2662   Protein   NP_660092   MAX   MAX protein       2663   DNA   NM_005532   IFI27   interferon, alpha-inducible                       protein 27       2664   Protein   NP_005523   IFI27   interferon, alpha-inducible                       protein 27       2665   DNA   NM_000244   MEN1   multiple endocrine neoplasia I       2666   Protein   NP_000235   MEN1   multiple endocrine neoplasia I       2667   DNA   NM_130799   MEN1   multiple endocrine neoplasia I       2668   Protein   NP_570711   MEN1   multiple endocrine neoplasia I       2669   DNA   NM_130800   MEN1   multiple endocrine neoplasia I       2670   DNA   NM_130801   MEN1   multiple endocrine neoplasia I       2671   DNA   NM_130802   MEN1   multiple endocrine neoplasia I       2672   DNA   NM_130803   MEN1   multiple endocrine neoplasia I       2673   DNA   NM_130804   MEN1   multiple endocrine neoplasia I       2674   DNA   NM_004964       Histone deacetylase HD1,                       mRNA sequence       2675   Protein   NP_004955       Histone deacetylase HD1,                       mRNA sequence       2676   DNA   BA-13885       Histone deacetylase HD1,                       mRNA sequence       2677   DNA   NM_003743   NCOA1   nuclear receptor coactivator 1       2678   Protein   NP_003734   NCOA1   nuclear receptor coactivator 1       2679   DNA   NM_147223   NCOA1   nuclear receptor coactivator 1       2680   Protein   NP_671756   NCOA1   nuclear receptor coactivator 1       2681   DNA   NM_147233   NCOA1   nuclear receptor coactivator 1       2682   Protein   NP_671766   NCOA1   nuclear receptor coactivator 1       2683   DNA   NM_001893       Casein kinase I delta, mRNA                       sequence       2684   Protein   NP_001884       Casein kinase I delta, mRNA                       sequence       2685   DNA   NM_007065   CDC37   CDC37 cell division cycle 37                       homolog ( S. cerevisiae )       2686   Protein   NP_008996   CDC37   CDC37 cell division cycle 37                       homolog ( S. cerevisiae )       2687   DNA   NM_000534   PMS1   PMS1 postmeiotic segregation                       increased 1 ( S. cerevisiae )       2688   Protein   NP_000525   PMS1   PMS1 postmeiotic segregation                       increased 1 ( S. cerevisiae )       2689   DNA   NM_000535   PMS2   PMS2 postmeiotic segregation                       increased 2 ( S. cerevisiae )       2690   Protein   NP_000526   PMS2   PMS2 postmeiotic segregation                       increased 2 ( S. cerevisiae )       2691   DNA   NM_001809   CENPA   centromere protein A, 17 kDa       2692   Protein   NP_001800   CENPA   centromere protein A, 17 kDa       2693   DNA   NM_004419   DUSP5   dual specificity phosphatase 5       2694   Protein   NP_004410   DUSP5   dual specificity phosphatase 5       2695   DNA   NM_002887   RARS   arginyl-tRNA synthetase       2696   Protein   NP_002878   RARS   arginyl-tRNA synthetase       2697   DNA   NM_005521   TLX1   T-cell leukemia, homeobox 1       2698   Protein   NP_005512   TLX1   T-cell leukemia, homeobox 1       2699   DNA   NM_003318   TTK   TTK protein kinase       2700   Protein   NP_003309   TTK   TTK protein kinase       2701   DNA   NM_001291   CLK2   CDC-like kinase 2       2702   Protein   NP_001282   CLK2   CDC-like kinase 2       2703   DNA   NM_003993   CLK2   CDC-like kinase 2       2704   Protein   NP_003984   CLK2   CDC-like kinase 2       2705   DNA   HG3635-HT3845       Zinc Finger Protein, Kruppel-                       Like       2706   DNA   HG1322-HT5143       Small Nuclear                       Ribonucleoprotein, Polypeptide                       C, Alt. Splice 2       2707   DNA   HG1751-HT1768       Chorionic                       Somatomammotropin Hormone                       Cs-5       2708   DNA   NM_004341   CAD   carbamoyl-phosphate                       synthetase 2, aspartate                       transcarbamylase, and                       dihydroorotase       2709   Protein   NP_004332   CAD   carbamoyl-phosphate                       synthetase 2, aspartate                       transcarbamylase, and                       dihydroorotase       2710   DNA   NM_006145   DNAJB1   DnaJ (Hsp40) homolog,                       subfmaily B, member 1       2711   Protein   NP_006136   DNAJB1   DnaJ (Hsp40) homolog,                       subfmaily B, member 1       2712   DNA   NM_004039   ANXA2   annexin A2       2713   Protein   NP_004030   ANXA2   annexin A2       2714   DNA   NM_002643   PIGF   phosphatidylinositol glycan,                       class F       2715   Protein   NP_002634   PIGF   phosphatidylinositol glycan,                       class F       2716   DNA   NM_173074   PIGF   phosphatidylinositol glycan,                       class F       2717   Protein   NP_775097   PIGF   phosphatidylinositol glycan,                       class F       2718   DNA   NM_006468   RPC62   polymerase (RNA) III (DNA                       directed) (62 kD)       2719   Protein   NP_006459   RPC62   polymerase (RNA) III (DNA                       directed) (62 kD)       2720   DNA   NM_003220   TFAP2A   transcription factor AP-2 alpha                       (activating enhancer binding                       protein 2 alpha)       2721   Protein   NP_003211   TFAP2A   transcription factor AP-2 alpha                       (activating enhancer binding                       protein 2 alpha)       2722   DNA   NM_000946   PRIM1   primase, polypeptide 1, 49 kDa       2723   Protein   NP_000937   PRIM1   primase, polypeptide 1, 49 kDa       2724   DNA   NM_003913   PRPF4B   PRP4 pre-mRNA processing                       factor 4 homolog B (yeast)       2725   Protein   NP_003904   PRPF4B   PRP4 pre-mRNA processing                       factor 4 homolog B (yeast)       2726   DNA   NM_000956   PTGER2   prostaglandin E receptor 2                       (subtype EP2), 53 kDa       2727   Protein   NP_000947   PTGER2   prostaglandin E receptor 2                       (subtype EP2), 53 kDa       2728   DNA   NM_004398   DDX10   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 10                       (RNA helicase)       2729   Protein   NP_004389   DDX10   DEAD/H (Asp-Glu-Ala-                       Asp/His) box polypeptide 10                       (RNA helicase)       2730   DNA   NM_003345   UBE2I   ubiquitin-conjugating enzyme                       E2I (UBC9 homolog, yeast)       2731   Protein   NP_003336   UBE2I   ubiquitin-conjugating enzyme                       E2I (UBC9 homolog, yeast)       2732   DNA   NM_003463   PTP4A1   protein tyrosine phosphatase                       type IVA, member 1       2733   Protein   NP_003454   PTP4A1   protein tyrosine phosphatase                       type IVA, member 1       2734   DNA   NM_006164   NFE2L2   nuclear factor (erythroid-                       derived 2)-like 2       2735   Protein   NP_006155   NFE2L2   nuclear factor (erythroid-                       derived 2)-like 2       2736   DNA   NM_006284   TAF10   TAF10 RNA polymerase II,                       TATA box binding protein                       (TBP)-associated factor, 30 kDa       2737   Protein   NP_006275   TAF10   TAF10 RNA polymerase II,                       TATA box binding protein                       (TBP)-associated factor, 30 kDa       2738   DNA   NM_000801   FKBP1A   FK506 binding protein 1A,                       12 kDa       2739   Protein   NP_000792   FKBP1A   FK506 binding protein 1A,                       12 kDa       2740   DNA   NM_054014   FKBP1A   FK506 binding protein 1A,                       12 kDa       2741   DNA   NM_003403   YY1   YY1 transcription factor       2742   Protein   NP_003394   YY1   YY1 transcription factor       2743   DNA   NM_002415   MIF   macrophage migration                       inhibitory factor (glycosylation-                       inhibiting factor)       2744   Protein   NP_002406   MIF   macrophage migration                       inhibitory factor (glycosylation-                       inhibiting factor)       2745   DNA   NM_000296   PKD1   polycystic kidney disease 1                       (autosomal dominant)       2746   Protein   NP_000287   PKD1   polycystic kidney disease 1                       (autosomal dominant)       2747   DNA   NM_006243   PPP2R5A   protein phosphatase 2,                       regulatory subunit B (B56),                       alpha isoform       2748   Protein   NP_006234   PPP2R5A   protein phosphatase 2,                       regulatory subunit B (B56),                       alpha isoform       2749   DNA   NM_014235   UBL4   ubiquitin-like 4       2750   Protein   NP_055050   UBL4   ubiquitin-like 4       2751   DNA   NM_004156   PPP2CB   protein phosphatase 2 (formerly                       2A), catalytic subunit, beta                       isoform       2752   Protein   NP_004147   PPP2CB   protein phosphatase 2 (formerly                       2A), catalytic subunit, beta                       isoform       2753   DNA   NM_006332   IFI30   interferon, gamma-inducible                       protein 30       2754   Protein   NP_006323   IFI30   interferon, gamma-inducible                       protein 30       2755   DNA   NM_002811   PSMD7   proteasome (prosome,                       macropain) 26S subunit, non-                       ATPase, 7 (Mov34 homolog)       2756   Protein   NP_002802   PSMD7   proteasome (prosome,                       macropain) 26S subunit, non-                       ATPase, 7 (Mov34 homolog)       2757   DNA   NM_002806   PSMC6   proteasome (prosome,                       macropain) 26S subunit,                       ATPase, 6       2758   Protein   NP_002797   PSMC6   proteasome (prosome,                       macropain) 26S subunit,                       ATPase, 6       2759   DNA   NM_003262   TLOC1   translocation protein 1       2760   Protein   NP_003253   TLOC1   translocation protein 1       2761   DNA   NM_004954   MARK2   MAP/microtubule affinity-                       regulating kinase 2       2762   Protein   NP_004945   MARK2   MAP/microtubule affinity-                       regulating kinase 2       2763   DNA   NM_017490   MARK2   MAP/microtubule affinity-                       regulating kinase 2       2764   Protein   NP_059672   MARK2   MAP/microtubule affinity-                       regulating kinase 2       2765   DNA   NM_014264   STK18   serine/threonine kinase 18       2766   Protein   NP_055079   STK18   serine/threonine kinase 18       2767   DNA   NM_002969   MAPK12   mitogen-activated protein                       kinase 12       2768   Protein   NP_002960   MAPK12   mitogen-activated protein                       kinase 12       2769   DNA   K03022   U2 small   U2 small nuclear RNA gene                   nuclear RNA       2770   DNA   AK027091   FLJ23438 fis,   FLJ23438 fis, clone HRC13275                   clone                   HRC13275       2771   DNA   AL833005   cDNA   cDNA DKFZp666D074                   DKFZp666D074       2772   DNA   BC003629   clone   clone MGC: 2854                   MGC: 2854   IMAGE: 2987935                   IMAGE: 2987935       2773   DNA   L37793   small nuclear   small nuclear RNA (U2) gene                   RNA (U2)                   gene       2774   DNA   U57614   U2 snRNA   U2 snRNA (RNU2) gene                   (RNU2) gene                  
 
         [0063]     Analogs of the biomarkers provided in Table 1 are also within the scope of the invention. Analogs can differ from the naturally occurring biomarker in nucleotide or amino acid sequence or in ways that do not involve sequence, or both. Non-sequence modifications include in vivo or in vitro chemical derivitization. Non-sequence modifications also include changes in acetylation, methylation, phosphorylation, carboxylation, or glycosylation.  
         [0064]     Preferred analogs of the biomarkers provided in Table 1 (or biologically active fragments thereof) include those whose sequences differ from the wild-type sequences by one or more conservative amino acid substitutions or by one or more non-conservative amino acid substitutions, deletions, or insertions which do not abolish biological activity. Conservative substitutions typically include, for example, the substitution of one amino acid for another with similar characteristics, e.g., substitutions within the following groups: valine, glycine; glycine, alanine; valine, isoleucine, leucine; aspartic acid, glutamic acid; asparagine, glutamine; serine, threonine; lysine, arginine; and phenylalanine, tyrosine.  
         [0065]     The biomarkers of the invention include any biological molecule that can be detected and quantified in a biological sample using standard biochemical assay methods, where the presence and/or quantity of the biomarker in the biological sample: (i) can be used to select an appropriate treatment; or (ii) can be used to monitor the efficacy and progress of treatment with a cdk modulating agent.  
         [0066]     In one aspect, the invention includes the biomarker provided in SEQ ID NO:1246 and assigned GenBank Accession No. W28729. It has been discovered that this biomarker has an expression pattern that correlates with inhibition of cdk in cells upon treatment with a cdk modulating agent. The biomarker of SEQ ID NO:1246 was discovered to have the most consistent and robust regulation in response to cdk inhibition.  
         [0067]     The invention also includes specialized microarrays, e.g., oligonucleotide microarrays or cDNA microarrays, comprising one or more biomarkers.  
         [0068]     The invention also includes kits comprising a suitable container that comprises: one or more microarrays that comprise one or more biomarkers; one or more cdk modulating agents for use in testing cells from patient tissue specimens or patient samples; and instructions for use. In addition, kits contemplated by the invention can further include, for example, reagents or materials for monitoring the expression of biomarkers of the invention at the level of mRNA or protein, using other techniques and systems practiced in the art such as, for example, RT-PCR assays, which employ primers designed on the basis of one or more of the biomarkers described herein, immunoassays, such as enzyme linked immunosorbent assays (ELISAs), immunoblotting, e.g., Western blots, or in situ hybridization, and the like, as further described herein.  
         [0069]     The invention also includes antibodies, including polyclonal or monoclonal, directed against one or more of the biomarker polypeptides. Such antibodies can be used in a variety of ways, for example, to purify, detect, and target the biomarker polypeptides of the invention, including both in vitro and in vivo diagnostic, detection, screening, and/or therapeutic methods.  
         [0070]     In carrying out any of the methods of the invention, the levels of either a single biomarker or a set of two or more different biomarkers can be assayed. Assay of more than one biomarker may serve to increase the accuracy of monitoring the response of the patient to treatment with the cdk modulating agent, such as the extent of cdk2 inhibition. Measurement of a plurality of biomarkers can be carried out by assaying the different biomarkers in either the same biological sample or in different biological samples taken from the same patient.  
         [0071]     In one aspect, the invention provides a method to monitor the response of a patient being treated for a disorder by administration of a cdk modulating agent, comprising: (a) determining the amount of at least one biomarker in a first biological sample taken from the patient prior to an initial treatment with the agent; (b) determining the amount of the biomarker in at least a second biological sample from the patient subsequent to the initial treatment with the agent; and (c) comparing the amount of the biomarker present in the second biological sample with the amount of the biomarker present in the first biological sample; such that a detectable change in the amount of the biomarker in the second biological sample, and/or in any subsequent biological samples, compared to the amount of biomarker present in the first biological sample indicates that the patient is responding positively to the treatment with the agent The detectable change can be a decrease or an increase in the amount of the biomarker in the second biological sample, and/or in any subsequent biological samples.  
         [0072]     This method requires that at least two biological samples are taken from the patient at different time points. The first sample is typically obtained prior to an initial treatment with the cdk modulating agent. A second sample is then obtained, and any subsequent samples are also then obtained, after treatment with the cdk modulating agent has begun. In this method, the biomarker is monitored to determine: (i) if the amount of the biomarker is decreasing, (ii) if the rate of decrease in the amount of the biomarker is increasing, (iii) if the amount of the biomarker is increasing, (iv) if the rate of increase in the amount of the biomarker is increasing, or (v) if the amount of biomarker is stabilizing, any one of which may indicate that the patient is responding positively to the treatment depending upon the specific circumstances.  
         [0073]     The biomarkers described herein may be upregulated or down-regulated following treatment with one or more cdk modulating agents.  
         [0074]     When the biomarker is an upregulated biomarker, it is expected that the amount of the biomarker will increase following treatment with the cdk modulating agent, i.e., that there will be a detectable increase in the amount of the biomarker in the second biological sample (post administration of the cdk modulating agent) compared to the amount of biomarker in the first biological sample (prior to administration of the cdk modulating agent). If the biomarker is an upregulated biomarker and the level of the biomarker has not increased a predetermined or detectable amount, or if the rate of increase of the biomarker level is not sufficiently high, the treatment can be modified, such as by increasing the dosage or the number of treatments, or by changing the cdk modulating agent being administered to a more effective agent, or by combining the cdk modulating agent being used in the treatment with one or more other cdk modulating agents or therapies, or some combination thereof.  
         [0075]     When the biomarker is a downregulated biomarker, it is expected that the amount of the biomarker will decrease following treatment with the cdk modulating agent, i.e., that there will be a detectable decrease in the amount of the biomarker in the second biological sample (post administration of the cdk modulating agent) compared to the amount of biomarker in the first biological sample (prior to administration of the cdk modulating agent). If the biomarker is a down-regulated biomarker and the level of the biomarker has not decreased a predetermined or detectable amount, or if the rate of decrease of the biomarker level is not sufficiently high, the treatment can be modified, such as by increasing the dosage or the number of treatments, or by changing the cdk modulating agent being administered to a more effective agent, or by combining the cdk modulating agent being used in the treatment with one or more other cdk modulating agents or therapies, or some combination thereof.  
         [0076]     The invention further provides an improvement to a method for treating a patient suffering from a disorder by administration of a cdk modulating agent, wherein the improvement comprises monitoring the level of at least one biomarker in a biological sample taken from the patient at one or more time points during treatment with the agent so as to determine whether an effective amount of the agent is being administered to the patient. An effective amount of the agent is being administered to the patient if the level of a downregulated biomarker in the biological sample detectably decreases, or if a previously observed rate of decrease in the level of the biomarker increases, in response to administration of the agent. In addition, an effective amount of the agent is being administered to the patient if the level of an upregulated biomarker in the biological sample detectably increases, or if a previously observed rate of increase in the level of the biomarker increases, in response to administration of the agent.  
         [0077]     The invention further provides an improvement to a method for treating a patient suffering from a disorder by administration of a cdk modulating agent, wherein the improvement comprises monitoring the level of at least one biomarker in a biological sample taken from the patient at one or more time points during treatment with the agent so as to determine when a sufficient time course of treatment with the agent has been completed. In one embodiment, a sufficient time course of treatment with the agent has been completed when the level of a downregulated biomarker detectably decreases below a predetermined level. In another embodiment, a sufficient time course of treatment with the agent has been completed when the level of an upregulated biomarker detectably increases above a predetermined level.  
         [0078]     The type of biological sample from which the amount of biomarker is determined will depend on a variety of factors such as the particular biomarker, where and when it is synthesized, where the biomarker may be stored in the tissues, and into what biological tissue or fluid it may be released or otherwise accumulate. Generally, the biological sample will be selected from the group consisting of blood, a blood component such as serum or plasma, cerebrospinal fluid (CSF), saliva, and urine. In one aspect, the biological sample will be blood, serum, plasma, or CSF, and most preferably blood, serum, or plasma. Where more than one biomarker is analyzed, the analysis can be conducted on the same or different biological samples obtained from the patient.  
         [0079]     The amount of the biomarker in a biological sample can be determined using standard techniques known in the art. For example, each biomarker can be assayed using biomarker-specific antibodies and immunological methods known in the art. Any appropriate immunoassay method can be used, including radioimmiunoassays, sandwich enzyme-linked immunoassays, competitive binding assays, homogeneous assays, and heterogeneous assays. Alternatively, the amount of biomarker can be determined using other techniques such as magnetic resonance spectroscopy, HPLC, or mass spectrometry. In any case, the assay method selected should be sensitive enough to be able to measure the particular biomarker in a concentration range from normal values found in healthy patients to elevated levels indicating neurological damage. The assay can be carried out in various formats including, e.g., in a microtiter plate format, using automated immunoassay analyzers known in the art.  
         [0080]     As used herein, the predetermined level of the biomarker in the biological sample refers to that amount or concentration of the particular biomarker in a biological sample wherein the amount of the biomarker is higher (upregulated biomarkers) or lower (downregulated biomarkers) statistically than that determined to be present in a biological sample obtained from the patient absent the treatment with the cdk modulating agent. The predetermined level depends upon the particular biomarker.  
         [0081]     The expression level of the biomarker provides information about the patient&#39;s likely response to treatment with a cdk modulating agent. For this purpose, it is often desirable to correct for (normalize away) both differences in the amount of RNA assayed and variability in the quality of the RNA used. Therefore, the assay typically measures and incorporates the expression of certain normalizing genes, including well known housekeeping genes, such as GAPDH and CYPL. Alternatively, or in addition, normalization can be based on the mean or median signal (Ct in the case of RT-PCR) of all of the assayed genes or a large subset thereof (global normalization approach). On a gene-by-gene basis, measured normalized amount of a patient tumor mRNA is compared to the amount found in a reference set of cancer tissue of the same type. The number (N) of cancer tissues in this reference set should be sufficiently high to ensure that different reference sets (as a whole) behave essentially the same way. If this condition is met, the identity of the individual cancer tissues present in a particular set will have no significant impact on the relative amounts of the genes assayed. The cancer tissue reference set can, in one aspect, consist of at least about 30 different cancer tissue specimens.  
         [0082]     While the data described herein were generated in cell lines that are routinely used to screen and identify compounds that have potential utility for cancer therapy, the biomarkers may have both diagnostic and prognostic value in other diseases areas in which cdk or pathways in which cdk is involved is of importance, e.g., in immunology, or in cancers or tumors in which cell signaling and/or proliferation controls have gone awry.  
         [0083]     Those having skill in the pertinent art will appreciate that cdk and pathways in which cdk is involved are used and functional in cell types other than cell lines of ovarian carcinoma cells and peripheral blood mononuclear cells. Therefore, the biomarkers and biomarker sets of the invention may show utility in cells from other tissues or organs associated with a disease state, or cancers or tumors derived from other tissue types. Non-limiting examples of such cells, tissues and organs include breast, colon, lung, prostate, testes, ovaries, cervix, esophagus, pancreas, spleen, liver, kidney, stomach, lymphocytic and brain, thereby providing a broad and advantageous applicability to the biomarkers described herein Cells for analysis can be obtained by conventional procedures as known in the art, for example, tissue biopsy, aspiration, sloughed cells, e.g., colonocytes, clinical or medical tissue or cell sampling procedures.  
       EXAMPLES  
       [0084]     As described below, transcription profiling was used to identify the biomarkers provided above in Table 1. Specifically, transcription profiling of the effect of a certain cdk2 inhibitor on peripheral blood mononuclear cells (PBMCs) was first performed. Next, profiling of a cdk2 inhibitor-treated tumor cell line A2780 at multiple doses and time points was performed to establish a correlation of tumor site response with peripheral blood biomarkers. In order to establish the molecular target-specificity of the potential biomarkers, tumor cell line A2780 treated with anti-cdk2 oligonucleotides was also profiled. Overlapping gene expression changes, as shown in  FIG. 1 , were selected for further evaluation in human ovarian carcinoma xenograft A2780 that were treated with the cdk2 inhibitor (Example 2). The selected biomarkers were subjected to real-time PCR analysis in order to verify the observed changes from the gene chip analysis. These biomarkers are provided above in Table 1.  
         [0085]     In the examples below, the following conditions were employed.  
         [0086]     Cdk2 Inhibitor: The cdk2 inhibitor of the examples is N-5-[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl-4-piperidinecarboxamide, 0.5-L-tartaric acid salt:  
                         
 
 This cdk2 inhibitor was solubilized in 100% DMSO at a concentration of 10 mM. Compound dilutions were made into respective growth media 
 
         [0087]     Cell Culture: The cell lines were maintained in RPMI-1640 plus 10% fetal bovine serum.  
         [0088]     Clonogenic Growth Assay: The colony growth inhibition was measured for the A2780 ovarian carcinoma cells using a standard clonogenic assay. In this assay, 200 cells/well were seeded into 6-well tissue culture plates (Falcon™) (Becton, Dickinson and Company, Franklin Lakes, N.J., USA) and allowed to attach for 18 hours. Assay medium consisted of RPMI-1640 plus 10% fetal bovine serum. Cells were then treated in duplicate with a six concentration dose-response curve. The maximum concentration of DMSO never exceeded 0.25%. Cells were exposed to the cdk2 inhibitor for 4, 8, or 24 hours. The cdk2 inhibitor was then removed and the cells were washed with 2 volumes of PBS. The normal growth medium was then replaced. Colonies were fed with fresh media every third day. Colony number was scored on day 10-14 using a Optimax imaging station. The cdk2 inhibitor concentration required to inhibit 50% or 90% of colony formation (IC 50  or IC 90 , respectively) was determined by non-linear regression analysis. The coefficient of variance (standard deviation/mean, n=3)=30%.  
         [0089]     Real-Time Quantitative PCR Assays: A Taqman® real-time-PCR fluorogenic assay (Applied Biosystems, Foster City, Calif., USA) was used to quantitate the levels of specific mRNA. The cdk2 inhibitor treated A2780s cells were harvested at approximately 70% confluence and total RNA was prepared using the Qiagen RNeasy 96 Kit.  
         [0090]     Taqman® reactions were prepared as follows: 100 ng total RNA; 25 nM-750 nM Forward Primer; 25 nM-750 nM Reverse Primer; 200 nM-400 nM Taqman® Probe (fluorescent dye labeled oligonucleotide primer); 1X Buffer A (Applied Biosystems, Foster City, Calif., USA); 5.5 mM MgCl 2 ; 300 μM DATP, dGTP, dTTP, dCTP; 1 U Amplitaq Gold; 20 U Superscript 2; 1 U RNase Inhibitor. Real-time PCR was performed using an Applied Biosystems 7700 Sequence Detection System. Conditions were as follows: 48° C. for 20 minutes (reverse transcription), 95° C. for 10 minutes (denaturation and activation of Amplitaq Gold), 40 cycles of PCR (95° C. for 15 seconds, 60° C. for 1 minutes).  
         [0091]     The Sequence Detection System generates a Ct (threshold cycle) value that is used to calculate a concentration for each input messenger RNA template. Messenger RNA levels for each gene or fragment thereof of interest were normalized to GAPDH message levels to compensate for variations in total RNA quantity in the input sample. This was done by generating GAPDH Ct values for each cell line. Ct values for the gene or fragments thereof of interest and GAPDH were inserted into the δδCt equation: 
 
Relative Quantity of Nucleic Acid Template=2 δδCt =2 (δCta-δCtb) (δ Cta=Ct  target− Ct GAPDH, δCtb=Ct  reference− Ct GAPDH ) 
 
 which was used to calculate a normalized relative message level. 
 
         [0092]     Gene Chip Analysis: Gene chips were used to quantitate the levels of gene expression on a large-scale with Affymetrix human gene chips HG-U95A, B, and C (Affymetrix, Inc., Santa Clara, Calif., USA). Gene chip hybridization was performed using an Affymetrix gene chip system including hybridization oven, washing station, scanner, and a computer workstation. Manufacturer&#39;s standard protocol was followed. Raw data were generated using Affymetrix Microarray Suite 4.0 software. A threshold of 20 units was assigned to any gene with a calculated expression level below 20, because discrimination of expression below this level could not be performed with confidence.  
         [0093]     In Vitro Treatment of PBMC: PBMCs were isolated and incubated with the cdk2 inhibitor in vitro. Specifically, approximately 40 ml of blood were collected for the pilot study and then from 10 volunteers. The 40 ml of blood were then put into five Vacutainer™ CPT™ Mononuclear Cell Preparation Tubes (Product Number: 362753) (Becton, Dickinson and Company, Franklin Lakes, N.J., USA) with Sodium Heparin Anticoagulant 60/cs. Lymphocytes were then removed from the five Vacutainers™ pool and re-suspended in 20 ml of culture medium (RPMI, 10% serum, and glu/Pen/strep). Cells were counted at this step, and then centrifuged gently and then suspended with 4.0 ml of culture medium. Cells were then plated into 6 well plates (0.5 ml/well). Culture medium containing the cdk2 inhibitor or vehicle (3.5 ml) was then added to each well to give a final concentration of 100 nM cdk2 inhibitor in experimental wells, and also a final concentration of 1000 nM cdk2 inhibitor in experimental wells for the 10 subjects.  
         [0094]     RNA and protein samples were harvested at 4 and 24 hours after addition of the cdk2 inhibitor. RNA was prepared using the RNeasy-mini RNA kit according to the manufacturer&#39;s specifications (Qiagen, Valencia, Calif., USA). For protein samples, cells were washed once with PBS before extracting with 0.5-1.0 ml of modified RIPA buffer [50 mM Tris (pH 8), 150 mM NaCl, 1% NP-40, 0.5% Na-deoxycholate, 0.1% SDS, 0.1% Na3VO4, 0.1 mM NaF, 10 mM β-glycerophosphate, plus Complete® protease inhibitors (Boehringer Mannhiem GmbH, Germany)]. Lysates were frozen at −80° C. Viability of cells at different time points following the cdk2 inhibitor treatment was determined by trypan blue exclusion.  
         [0095]     Western Blot Analysis: The cdk2 inhibitor treated A2780s cells were harvested at approximately 70% confluence and total protein was prepared by lysing the cells in RIPA [50 mM Tris (pH 8), 150 mM NaCl, 1% NP-40, 0.5% Na-deoxycholate, 0.1% SDS, 0.1% Na3VO4, 0.1 mM NaF, 10 mM β-glycerophosphate, plus Complete® protease inhibitors (Boehringer Mannhiem GmbH, Germany)] buffer. Cell pellets were resuspended at a density of &lt;2× 10 7  cells/ml and incubated for 20 minutes on ice followed by a high speed 14,000 rpm centrifugation. The protein supernatant was then removed from the debris and protein content was quantitated using the Micro-BCA assay (Pierce Biotechnology, Inc., Rockford, Ill., USA). Treated extracts (25 μg/lane) were then separated using a 10% SDS-polyacrylamide gel (10.5× 14 cm). Proteins were then transferred from the gel to PVDF-membrane (Millipore Corporation, Billerica, Mass., USA) by exposure to 0.8 Amp/cm 2  in a semi-dry blotting apparatus (Hoefer Scientific Instruments, San Francisco, Calif., USA). PVDF protein blots were then blocked with 5% non-fat milk in TTBS (0.1% Tween 20 in Tris-buffered saline). Blots were then probed with primary antibody (mouse anti-cdk2 clone D-12, Santa Cruz Biotechnology, Santa Cruz, Calif., USA) in 5% non-fat milk in TTBS for 1-2 hours, followed by three washes with TTBS. An HRP-conjugated secondary antibody (HRP conjugated goat anti-mouse IgG, Promega Corp., Madison, Wis., USA) was then incubated with the blots in TTBS for 30 minutes. The blots were then washed three times with TTBS and developed with ECL-plus western blotting detection system (Amersham Biosciences, Piscataway, N.J., USA).  
         [0096]     Cdk2 Antisense Treatment: A mixture of five antisense oligonucleotides targeted against cdk2 mRNA having the following sequences was used:  
         [0097]     GCAGUAUACCUCUCGCUCUUGUCAA (SEQ ID NO:2775); UUUGGAAGUUCUCCAUGAAGCGCCA (SEQ ID NO:2776); GUCCAAAGUCUGCUAGCUUGAUGGC (SEQ ID NO:2777); CCCAGGAGGAUUUCAGGAGCUCGGU (SEQ ID NO:2778); UAGAAGUAACUCCUGGCCACACCAC (SEQ ID NO:2779). All gene modulations were based on relative levels of RNA in antisense treated cells versus reverse control oligonucleotide treated cells.  
         [0098]     A2780s cells were plated in 6-well tissue culture plates at a density of 1-2×10 5  cells/well. After an overnight incubation, cells were transfected with the antisense oligonucleotide mixture using Lipofectamine 2000 (Invitrogen Life Technologies, Carlsbad, Calif., USA). Briefly, a 10× lipid solution (10 ug/ml in OptiMEM) and a 10× oligonucleotide mixture (0.5 uM in OptiMEM) were prepared. A 5× solution of lipid/oligonucleotide complex was then prepared by mixing equal volumes of 10× lipid solution and 10× oligonucleotide mixture. The 5× solution of lipid/oligonucleotide complex was allowed to incubate at room temperature for 15 minutes to allow complexes to form. After incubation, the 5× lipid/oligonucleotide complex was diluted in RPMI containing 10% Fetal Bovine Serum to produce a 1× transfection reagent Cells in 6-well culture plates were transfected by replacing the overnight growth media with 1× transfection reagent. Cells were then incubated at various times (0, 12, 16, 20, and 24 hours) prior to harvesting RNA for analysis by Taqman® real-time-PCR fluorogenic assay. In every experiment, an extra well was transfected with a fluoresceinated random oligonucleotide to determine the transfection efficiency using flow cytometry. For all experiments, between 85% and 95% of A2780s cells were transfected.  
       Example 1  
     Transcription Profiling of Peripheral Blood Mononuclear Cells (PBMCs) Following Treatment with Cdk2 inhibitor, and A2780S Ovarian Carcinoma Cells Following Treatment with Cdk2 inhibitor or Anti-cdk2 Antisense Oligonucleotides  
       [0099]     To identify biomarkers, transcriptional profiling was obtained for (i) PBMCs following treatment with cdk2 inhibitor, (ii) A2780S ovarian carcinoma cells following treatment with cdk2 inhibitor, and (iii) A2780S ovarian carcinoma cells following treatment with anti-cdk2 antisense oligonucleotides.  
         [0100]     Table 2 lists the doses and time course used for treatment of the A2780 and PBMC cell types.  
                                 TABLE 2                           Experimental design                    Drug Dose   Time course       Cell Type   Treatment   (nM)   (hours)               A2780   cdk2 inhibitor   0, 20, 100, 200   0, 1, 2, 4, 6, 24       PBMC   cdk2 inhibitor   0, 100   0, 4, 24       (pooled 10       subjects)       PBMC   cdk2 inhibitor   0, 100, 1000   0, 4, 24       (pilot)       A2780   Anti-cdk2   Antisense oligo and   0, 12, 16, 20, 24           oligonucleotide   control                  
 
         [0101]     Treatment of A2780 and PBMC was carried out as described above. The doses of the cdk2 inhibitor were derived from an understanding of the kinetics of tumor cell growth inhibition by the cdk2 inhibitor as assessed by proliferation and clonogenic assays (Table 3). This study clearly demonstrated that growth inhibition by the cdk2 inhibitor was time dependent. A minimal exposure of 8 hours was required for effective inhibition of colony formation. The values obtained from the 24 hour clonogenic assay were in good agreement with the 72 hour proliferation assay.  
                                           TABLE 3                           Inhibition of colony formation by cdk2 inhibitor                IC 50  (nM)   IC 90  (nM)                        A2780s Clonogenic assay, 4 hr. exposure   302   &gt;1000       A2780s Clonogenic assay, 8 hr. exposure   154   303       A2780s Clonogenic assay, 24 hr.   166   208       exposure       A2780s, 72 hr. XTT assay   95   170                  
 
         [0102]     A pilot experiment of ex vivo treatment of PBMC from one healthy volunteer with the cdk2 inhibitor was first performed. Subsequently, PBMCs from ten healthy human subjects were collected and treated ex vivo with the cdk2 inhibitor. Total RNA was isolated and hybridized to gene chips.  
         [0103]     Antisense inhibition of cdk2 expression was optimized for A2780 cells and carried out as described above. Under these conditions, cdk2 protein levels decreased 90% after 24 hours exposure. As shown in  FIG. 2A , consistent reduction of cdk2 protein was observed in all three antisense treated wells (AS) relative to the controls wells (C). This resulted in a block in cell cycle progression and apoptosis that is similar to the cdk2 inhibitor treated A2780s cells. The decrease in cdk2 protein in relation to time of exposure was also determined. As shown in  FIG. 2B , cdk2 levels were maximally inhibited at 12 hours and protein levels remained reduced through 24 hours.  
       Example 2  
     Selection of Biomarkers  
       [0104]     In order to identify biomarkers for the cdk2 inhibitor that can be used as surrogate endpoints in PBMC and have molecular target-specific response, the expression profiles of the three sets of experiments in Example 1 were compared. Overlapping gene expression changes were selected as shown in  FIG. 1 .  
         [0105]     To allow for the identification of cdk2 specific responses as well as compound specific changes at gene expression level, a statistical method was used to select genes that have gene expression changes associated with dose and time of treatment in the cdk2 inhibitor treated A2780s sample set. The data were analyzed using an analysis of variance (ANOVA) model to study the compound&#39;s dose effect and time effect on each gene. First, the data were rescaled to eliminate the chip effects by a linear regression technique. Then, an ANOVA model was fitted for each gene based on two factors—dose and time. The F-test was used to determine if there was significant dose or time effect in terms of the changes in the expression level of a particular gene. Genes with the p-value less than 0.05 in both dose effect test and time effect test were identified. The genes identified with a p-value of less than 0.05 in both dose effect and time effect are provided Table 1.  
         [0106]     Overlapping gene expression changes from the three sets of Example 1 were selected for further evaluation in human ovarian carcinoma xenograft A2780 treated with the cdk2 inhibitor.  
         [0107]     The human ovarian carcinoma xenograft A2780s were maintained in Balb/c nu/nu nude mice. Tumors were propagated as subcutaneous (sc) transplants using tumor fragments obtained from donor mice. For the cdk2 inhibitor treatment, tumors were allowed to grow to the pre-determined size window of approximately 100-200 mg (tumors outside the range were excluded) and animals were evenly distributed to various treatment and control groups (n=6). Treatment of each animal was based on individual body weight.  
         [0108]     The cdk2 inhibitor was first dissolved in a mixture of Cremophor®/ethanol (50:50). One hour prior to administration, the cdk2 inhibitor was diluted with water so that the dosing solutions contained the specified excipient composition, i.e., Cremophor®/ethanol/water (1:1:8, v/v). The volume of all compounds injected was 0.01 ml/gm of mice. The cdk2 inhibitor was administered as a bolus injection intraperitoneal at doses of 36 and 18 mg/kg. Tumor and plasma were sampled at the time points of 4, 7, and 24 hour post treatment. Plasma sample was frozen immediately at −80° C. for pharmacokinetic analysis, and tumor sample was preserved in RNAase free buffer for pharmacogenomic analysis.  
         [0109]     Once certain genes were selected as potential biomarkers, real-time PCR assays using fluorescent MGB Taq-man probes were developed as described above.  
         [0110]     The selected genes were subjected for real-time PCR analysis as described above in order to verify the observed changes from gene chip analysis.  
         [0111]     The biomarker W28729 (SEQ ID NO: 1246) was selected as a preferred marker. A same-well multiplex real-time quantitative PCR assay on this biomarker with normalization control, house-keeping gene GAPDH, was developed using Taq-man MGB probes. Gene expression changes for W28729 were measured with real-time quantitative PCR assays in the following sample sets: A2780 human tumor cell line treated with 20 nM of cdk2 inhibitor for different durations ( FIG. 3A ), PBMC treated with 10n-M cdk2 inhibitor at 4 hours ( FIG. 3B ); and human ovarian carcinoma xenograft A2780 treated with cdk2 inhibitor at doses of 36 and 18 mg/kg for different durations ( FIG. 3C ). In cultured A2780 tumor cells, induction of W28729 occurred upon treatment with 20 nM of cdk2 inhibitor, and was detected 1 h after treatment. Upregulation of W28729 expression was also observed upon treatment of human PBMC in vitro with the cdk2 inhibitor. Treatment of nude mice bearing A2780 xenografts with efficacious doses of the cdk2 inhibitor also resulted in induction of W28729, and there was a dose-dependent prolongation of the duration of gene induction.  
       Example 3  
     W28729 Upregulation  
       [0112]     The following experimental methods were used to further study W28729 upregulation.  
         [0113]     Patient inclusion criteria: The patient inclusion criteria included: primary solid malignancy refractory to current therapy and adequate bone marrow, hepatic, and renal function.  
         [0114]     Treatments: Two different treatments were undertaken: (i) 174-001 Study: 1 hr infusion of BMS-387032 q 3 wks; and (ii) 174-002 Study: 24 hr infusion of BMS-387032 q 3 wks. The sampling times were pre-dose, and 2, 6, 24 hour post-dose.  
         [0115]     W28729 Expression Analysis: RT-PCR. Patient blood samples were collected in PAXgene™ Blood Collection Tubes (Qiagen, catalog #762155). Total RNA was isolated following the manufacturer&#39;s instructions using a PAXgene™ blood RNA Kit (Qiagen, catalog #762134). W28729 and GAPDH (housekeeping gene) RNA abundance was measured by Taqman assays, using an ABI PRISM 7900 HT Sequence Detection System. W28729 abundance was normalized relative to GAPDH. Primer and probe sequences are as shown below.  
                                   W28729:                   (5+)   AGTACCGTGAGGTTCCTGATGTG   (SEQ ID NO:2780)               (3+)   TGGCAAGCTGAGATCCTAAGG   (SEQ ID NO:2781)               Probe   TTATGCGGCAGCCTT   (SEQ ID NO:2782)               GAPDH:       (5+)   CGACAGTCAGCCGCATCTT   (SEQ ID NO:2783)               (3+)   AAATCCGTTGACTCCGACCTT   (SEQ ID NO:2784)               Probe   CATCGCTCAGACACCA   (SEQ ID NO:2785)          
 
 Results 
 
         [0116]     Preclinical Xenografts: In A2780 xenografts given bolus i.p. treatments with BMS-387032, the induction of W28729 in the tumors occurred in a transient, dose-dependent manner ( FIG. 4A ). At the minimum efficacious dose (MED) of 18 mg/kg/day, the induction was sustained for more than 6 hours. In an infusion regimen using the minimum efficacious dose of 40 mg/kg, gene induction was sustained for at least 16 hours. The gene induction in tumors was accompanied by a strikingly similar pattern of induction of the mouse ortholog sequence (SEQ ID NO:2786; a fragment of mouse genomic DNA sequence locus AL590994), as detected in PBMC isolated from the tumor mice ( FIG. 4B ). Treatment with an efficacious regimen results in &gt;2 fold induction of the sequence for 6 hours or longer. These data support the use of W28729 gene induction in tumor as a pharmacodynamic biomarker. In addition, these observations support the use of PBMC as a surrogate tissue for monitoring changes in gene expression, that result from treatment with the cdk2 inhibitor.  
         [0117]     Clinical Trials: In the CA174001 study (1 hour infusion), transient induction of W28729 was detected in PBMC at 2 hours and returned to baseline levels by 6 hours ( FIG. 5A ). In the CA174-002 study (24 hour infusion), there was modest induction of W28729 expression, which was sustained for 6 hours following end of infusion ( FIG. 5B ). Each line in  FIGS. 5A and 5B  represents the extent of gene induction for an individual patient at the specified times after dosing. There was an inverse relationship between baseline expression and the level of maximal gene induction in the CA174-001 study ( FIG. 6A ). There was no clear relationship between baseline expression and induction magnitude in the CA174-002 study ( FIG. 6B ). Interpretation of the data from the 24 hour infusion study is difficult because expression data were collected more than 24 hours after the beginning of dosing.  
         [0118]      FIGS. 7A and 7B  illustrate W28729 induction as a function of dose ( FIG. 7A ) and AUC ( FIG. 7B ) from the CA174-001. As shown in  FIGS. 7A and 7B , there was a linear relationship between W28729 gene induction and dose or exposure of the cdk2 inhibitor.  FIG. 8  provides a prediction of W28729 changes by baseline expression of W28729 and the cdk inhibitor exposure in the CA174-001 study. W28729 gene expression changes can be predicted by the formula: Δ(W28729 expression)=A*AUC*(Baseline expression) B , wherein A=0.000619 and B=−0.537. Induction of W28729 gene can be reliably predicted from drug exposure and baseline W28729 expression.  
         [0119]     Since the pre-clinical data suggest that the extent and duration of W28729 gene induction correlate with anti-tumor efficacy, the disease outcome of patients who showed different W28729 induction in the CA174-001 study was examined. Interestingly, those patients with high induction appeared to have the most favorable outcome ( FIG. 9 ). These results suggest that W28729 induction is a surrogate marker for prediction of clinical outcome of agents that modulate cdk.