PATENT ABSTRACT
Corticotropin releasing factor (CRF) antagonists of Formula (I)                            
     and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear palsy and eating disorders.

PATENT DESCRIPTION
This application is a divisional of U.S. patent application Ser. No. 08/929,935, filed Sep. 15, 1997, now U.S. Pat. No. 6,159,980, which claims the benefit of U.S. Provisional Application Ser. No. 60/026,373, filed Sep. 16, 1996. 
    
    
     FIELD OF THE INVENTION 
     This invention relates to novel compounds and pharmaceutical compositions, and to methods of using same in the treatment of psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear palsy and eating disorders. 
     BACKGROUND OF THE INVENTION 
     Corticotropin releasing factor (herein referred to as CRF), a 41 amino acid peptide, is the primary physiological regulator of proopiomelanocortin (POMC)-derived peptide secretion from the anterior pituitary gland [J. Rivier et al.,  Proc. Nat. Acad. Sci.  ( USA ) 80:4851 (1983); W. Vale et al.,  Science  213:1394 (1981)]. In addition to its endocrine role at the pituitary gland, immunohistochemical localization of CRF has demonstrated that the hormone has a broad extrahypothalamic distribution in the central nervous system and produces a wide spectrum of autonomic, electrophysiological and behavioral effects consistent with a neurotransmitter or neuromodulator role in brain [W. Vale et al.,  Rec. Prog. Horm. Res.  39:245 (1983); G. F. Koob,  Persp. Behav. Med.  2:39 (1985); E. B. De Souza et al.,  J. Neurosci.  5:3189 (1985)]. There is also evidence that CRF plays a significant role in integrating the response of the immune system to physiological, psychological, and immunological stressors [J. E. Blalock,  Physiological Reviews  69:1 (1989); J. E. Morley,  Life Sci.  41:527 (1987)]. 
     Clinical data provide evidence that CRF has a role in psychiatric disorders and neurological diseases including depression, anxiety-related disorders and eating disorders. A role for CRF has also been postulated in the etiology and pathophysiology of Alzheimer&#39;s disease, Parkinson&#39;s disease, Huntington&#39;s disease, progressive supranuclear palsy and amyotrophic lateral sclerosis as they relate to the dysfunction of CRF neurons in the central nervous system [for review see E. B. De Souza,  Hosp. Practice  23:59 (1988)]. 
     In affective disorder, or major depression, the concentration of CRF is significantly increased in the cerebral spinal fluid (CSF) of drug-free individuals [C. B. Nemeroff et al.,  Science  226:1342 (1984); C. M. Banki et al.,  Am. J. Psychiatry  144:873 (1987); R. D. France et al.,  Biol. Psychiatry  28:86 (1988); M. Arato et al.,  Biol Psychiatry  25:355 (1989)]. Furthermore, the density of CRF receptors is significantly decreased in the frontal cortex of suicide victims, consistent with a hypersecretion of CRF [C. B. Nemeroff et al.,  Arch. Gen. Psychiatry  45:577 (1988)]. In addition, there is a blunted adrenocorticotropin (ACTH) response to CRF (i.v. administered) observed in depressed patients [P. W. Gold et al.,  Am J. Psychiatry  141:619 (1984); F. Holsboer et al.,  Psychoneuroendocrinology  9:147 (1984); P. W. Gold et al.,  New Eng. J. Med.  314:1129 (1986)]. Preclinical studies in rats and non-human primates provide additional support for the hypothesis that hypersecretion of CRF may be involved in the symptoms seen in human depression [R. M. Sapolsky,  Arch. Gen. Psychiatry  46:1047 (1989)]. There is preliminary evidence that tricyclic antidepressants can alter CRF levels and thus modulate the numbers of CRF receptors in brain [Grigoriadis et al.,  Neuropsychopharmacology  2:53 (1989)]. 
     There has also been a role postulated for CRF in the etiology of anxiety-related disorders. CRF produces anxiogenic effects in animals and interactions between benzodiazepine/non-benzodiazepine anxiolytics and CRF have been demonstrated in a variety of behavioral anxiety models [D. R. Britton et al.,  Life Sci.  31:363 (1982); C. W. Berridge and A. J. Dunn  Regul. Peptides  16:83 (1986)]. Preliminary studies using the putative CRF receptor antagonist a-helical ovine CRF (9-41) in a variety of behavioral paradigms demonstrate that the antagonist produces “anxiolytic-like” effects that are qualitatively similar to the benzodiazepines [C. W. Berridge and A. J. Dunn  Horm. Behav.  21:393 (1987),  Brain Research Reviews  15:71 (1990)]. Neurochemical, endocrine and receptor binding studies have all demonstrated interactions between CRF and benzodiazepine anxiolytics providing further evidence for the involvement of CRF in these disorders. Chlordiazepoxide attenuates the “anxiogenic” effects of CRF in both the conflict test [K. T. Britton et al.,  Psychopharmacology  86:170 (1985); K. T. Britton et al.,  Psychopharmacology  94:306 (1988)] and in the acoustic startle test [N. R. Swerdlow et al.,  Psychopharmacology  88:147 (1986)] in rats. The benzodiazepine receptor antagonist (Ro15-1788), which was without behavioral activity alone in the operant conflict test, reversed the effects of CRF in a dose-dependent manner while the benzodiazepine inverse agonist (FG7142) enhanced the actions of CRF [K. T. Britton et al.,  Psychopharmacology  94:306 (1988)]. 
     The mechanisms and sites of action through which the standard anxiolytics and antidepressants produce their therapeutic effects remain to be elucidated. It has been hypothesized however, that they are involved in the suppression of the CRF hypersecretion that is observed in these disorders. Of particular interest is that preliminary studies examining the effects of a CRF receptor antagonist (a-helical CRF 9-41 ) in a variety of behavioral paradigms have demonstrated that the CRF antagonist produces “anxiolytic-like” effects qualitatively similar to the benzodiazepines [for review see G. F. Koob and K. T. Britton, In:  Corticotropin - Releasing Factor: Basic and Clinical Studies of a Neuropeptide , E. B. De Souza and C. B. Nemeroff eds., CRC Press p. 221 (1990)]. 
     DuPont Merck PCT application WO95/10506 describes corticotropin releasing factor antagonist compounds and their use to treat psychiatric disorders and neurological diseases. 
     European patent application 0 576 350 A1 by Elf Sanofi describes corticotropin releasing factor antagonist compounds useful in the treatment of CNS and stress disorders. 
     Pfizer patent applications WO 94/13676, WO 94/13677, WO 94/13661, WO 95/33750, WO 95/34563, WO 95/33727 describe corticotropin releasing factor antagonist compounds useful in the treatment of CNS and stress disorders. 
     All of the aforementioned references are hereby incorporated by reference. 
     The compounds and the methods of the present invention provide for the production of compounds capable of inhibiting the action of CRF at its receptor protein in the brain. These compounds would be useful in the treatment of a variety of neurodegenerative, neuropsychiatric and stress-related disorders such as affective disorders, anxiety, depression, post-traumatic stress disorders, supranuclear palsy, seizure disorders, stroke, irritable bowel syndrome, immune suppression, Alzheimer&#39;s disease, gastrointestinal disease, anorexia nervosa or other eating disorders, drug or alcohol withdrawal symptoms, drug addiction, inflammatory disorders and fertility problems. It is further asserted that this invention may provide compounds and pharmaceutical compositions suitable for use in such a method. 
     SUMMARY OF THE INVENTION 
     This invention is a class of novel compounds which are CRF receptor antagonists and which can be represented by Formula (I):                           
     or a pharmaceutically acceptable salt form thereof, wherein 
     Z is CR 2  or N; 
     when Z is CR 2 : 
     Y is NR 4 , O or S(O) n ; 
     Ar is phenyl, naphthyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, 1,3,5-triazinyl, 1,2,4-triazinyl, furanyl, quinolinyl, isoquinolinyl, thienyl, imidazolyl, thiazolyl, indolyl, indolinyl, pyrrolyl, oxazolyl, benzofuranyl, benzothienyl, 2,3-dihydrobenzofuranyl, 2,3-dihydrobenzothienyl, benzothiazolyl, indazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 4 R 5  groups; wherein Ar is attached to Y through an unsaturated carbon; 
     R 1  is H, halo, C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 8  cycloalkyl, C 1 -C 4  haloalkyl, aryl, heterocyclyl, —CN, —OR 7 , —SH, —S(O) n R 13 , —COR 7 , —CONR 6 R 7 , —CO 2 R 7 , —OC(O)R 13 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , or —NR 6 R 7 , wherein C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl or C 3 -C 8  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, halo, C 1 -C 4  haloalkyl, —CN, —OR 7 , —SH, —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —OC(O)R 13 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7 , —CONR 6 R 7 , aryl and heterocyclyl; 
     R 2  is H, C 1 -C 4  alkyl, C 2 -C 4  alkenyl, C 2 -C 4  alkynyl, C 3 -C 6  cycloalkyl, halo, —CN, C 1 -C 4  haloalkyl, —NR 9 R 10 , —NR 9 COR 10 , —NR 9 CO 2 R 10 , —OR 11 , —SH or —S(O) n R 12 ; 
     R 3  is C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 8  cycloalkyl, C 1 -C 4  haloalkyl, aryl, heterocyclyl, —CN, —OR 7 , —S(O) 2 R 13 , —COR 7 , —CO 2 R 7 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —CONR 6 R 7 , —NR 8 CO 2 R 7 , or —NR 6 R 7 , wherein C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl or C 3 -C 8  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, halo, C 1 -C 4  haloalkyl, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7 , —CONR 6 R 7 , aryl and heterocyclyl, with the proviso that when R 3  is aryl, Ar is not imidazolyl; 
     R 4  is H, C 1 -C 6  alkyl, C 2 -C 6  alkenyl or C 2 -C 6  alkynyl, wherein C 2 -C 6  alkenyl or C 2 -C 6  alkynyl is optionally substituted with C 1 -C 4  alkyl or C 3 -C 6  cycloalkyl and wherein C 1 -C 6  alkyl is optionally substituted with C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, —OR 7 , —S(O) n R 12 , —CO 2 R 7 , —NR 6 R 7  or —NR 9 COR 10 ; 
     R 5  is independently selected at each occurrence from C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, aryl, heterocyclyl, —NO 2 , halo, —CN, C 1 -C 4  haloalkyl, —NR 6 R 7 , —NR 8 COR 7 , —NR 8 CO 2 R 7 , —OR 7 , —COR 7 , —CO 2 R 7 , —CONR 6 R 7 , —CON(OR 9 )R 7 , —SH, and —S(O) n R 13 , wherein C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 6  cycloalkyl and C 4 -C 12  cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, —NO 2 , halo, —CN, —OR 7 , —COR 7 , —CO 2 R 7 , —CONR 6 R 7 , —NR 6 R 7 , —NR 8 COR 7 , —NR 8 CO 2 R 7  and —S(O) n R 13 ; 
     R 6  and R 7  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, aryl, aryl(C 1 -C 4  alkyl)-, heterocyclyl, heterocyclyl(C 1 -C 4  alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or —NR 6 R 7  taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine; wherein C 1 -C 4  alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from —OH or C 1 -C 4  alkoxy groups; 
     R 8  is independently at each occurrence H or C 1 -C 4  alkyl; 
     R 9  and R 10  are independently at each occurrence selected from H, C 1 -C 4  alkyl and C 3 -C 6  cycloalkyl; 
     R 11  is H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, or C 3 -C 6  cycloalkyl; 
     R 12  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl or —NR 6 R 7 ; 
     R 13  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, —NR 6 R 7 , aryl, aryl(C 1 -C 4  alkyl)-, heterocyclyl or heterocyclyl(C 1 -C 4  alkyl)-; 
     R 14  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, —NR 15 R 16 ; 
     R 15  and R 16  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl and C 4 -C 12  cycloalkylalkyl; or —NR 15 R 16  taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine; 
     aryl is phenyl, biphenyl or naphthyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, halo, C 1 -C 4  haloalkyl, —CN, —OR 15 , —SH, —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —OC(O)R 14 , —NO 2 , —NR 8 COR 15 , —N(COR 15 ) 2 , —NR 8 CONR 15 R 16 , —NR 8 CO 2 R 15 , —NR 15 R 16  and —CONR 15 R 16 ; 
     heterocyclyl is 5- to 10-membered heterocyclic ring which may be saturated, partially unsaturated or aromatic, and which consists of carbon atoms and from 1 to 4 heteroatoms independently selected from the group consisting of N, O and S, wherein the heterocyclic ring is substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, halo, C 1 -C 4  haloalkyl, —CN, —OR 15 , —SH, —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —OC(O)R 14 , —NR 8 COR 15 , —N(COR 15 ) 2 , —NR 8 CONR 15 R 16 , —NR 8 CO 2 R 15 , —NR 15 R 16 , and —CONR 15 R 16 ; and 
     n is independently at each occurrence 0, 1 or 2; 
     and wherein, when Z is N: 
     Y is NR 4 , O or S(O) n ; 
     Ar, R 1 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , aryl, heterocyclyl, heterocyclyl and n are as defined above, but 
     R 3  is C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 8  cycloalkyl, C 1 -C 4  haloalkyl, aryl, heterocyclyl, —CN, —S(O) 2 R 13 , —CO 2 R 7 , —COR 7  or —CONR 6 R 7 , wherein C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl or C 3 -C 8  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, halo, C 1 -C 4  haloalkyl, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7 , —CONR 6 R 7 , aryl and heterocyclyl, with the proviso that when R 3  is aryl, Ar is not imidazolyl. 
     [3] Preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein: 
     Z is CR 2 ; 
     Y is NR 4  or O; 
     Ar is phenyl or pyridyl, each substituted with 0 to 4 R 5  groups; 
     R 1  is H, halo, C 1 -C 4  alkyl, cyclopropyl, C 1 -C 4  haloalkyl, —CN, —NR 6 R 7 , —CONR 6 R 7 , —OR 7 , —COR 7 , —CO 2 R 7  or —S(O) n R 13 , wherein C 1 -C 4  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —NR 8 COR 7 , —NR 8 CO 2 R 7 , —NR 6 R 7  and aryl; 
     R 2  is H, C 1 -C 4  alkyl, halo, C 1 -C 4  haloalkyl; 
     R 3  is C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 8  cycloalkyl, C 1 -C 4  haloalkyl, aryl, heterocyclyl, —CN, —OR 7 , —S(O) 2 R 13 , —COR 7 , —CO 2 R 7 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —CONR 6 R 7 , —NR 8 CO 2 R 7 , or —NR 6 R 7 , wherein C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl or C 3 -C 8  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —CO 2 R 7 , —NR 8 COR 7 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7 , aryl and heterocyclyl; 
     R 4  is H, C 1 -C 6  alkyl or C 2 -C 6  alkenyl, wherein C 1 -C 6  alkyl is optionally substituted with C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, —OR 7 , —S(O) n R 12 , —CO 2 R 7 , —NR 6 R 7  or —NR 9 COR 10 ; 
     R 5  is independently selected at each occurrence from C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 4 -C 8  cycloalkylalkyl, aryl, heterocyclyl, C 1 -C 4  haloalkyl, halo, —CN, —NO 2 , —NR 6 R 7 , —COR 7 , —OR 7 , —CONR 6 R 7 , —CON(OR 9 )R 7 , CO 2 R 7  and —S(O) n R 13 , wherein C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl and C 4 -C 8  cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, —NO 2 , halo, —CN, —NR 6 R 7 , COR 7 , —OR 7 , —CONR 6 R 7 , CO 2 R 7  and —S(O) n R 13 ; 
     R 6  and R 7  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, aryl, aryl(C 1 -C 4  alkyl)-, heterocyclyl, heterocyclyl(C 1 -C 4  alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or —NR 6 R 7  taken together as a whole is piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine or thiomorpholine; wherein C 1 -C 4  alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from —OH or C 1 -C 4  alkoxy groups; 
     R 8  is independently at each occurrence H or C 1 -C 4  alkyl; 
     R 9  and R 10  are independently at each occurrence selected from H, C 1 -C 4  alkyl and C 3 -C 6  cycloalkyl; 
     R 11  is H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, or C 3 -C 6  cycloalkyl; 
     R 12  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl or —NR 6 R 7 ; 
     R 13  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, —NR 6 R 7 , aryl, aryl(C 1 -C 4  alkyl)-, heterocyclyl or heterocyclyl(C 1 -C 4  alkyl)-; 
     R 14  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, —NR 15 R 16 ; 
     R 15  and R 16  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl and C 4 -C 12  cycloalkylalkyl; or —NR 15 R 16  taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine; 
     aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —NO 2 , —NR 8 COR 15 , —NR 8 CONR 15 R 16 , —NR 8 CO 2 R 15  and —NR 15 R 16 ; 
     heterocyclyl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —CO 2 R 15 , —NO 2 , —NR 8 COR 15 , —NR 8 CONR 15 R 16 , —NR 8 CO 2 R 15 , and —NR 15 R 16 ; and 
     n is independently at each occurrence 0, 1 or 2. 
     [4] More preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein: 
     Z is CR 2 ; 
     Y is NR 4 ; 
     Ar is phenyl or pyridyl, each substituted with 0 to 4 R 5  groups; 
     R 1  is H, halo, C 1 -C 4  alkyl, cyclopropyl, C 1 -C 3  haloalkyl, —CN, —NR 6 R 7 , —CONR 6 R 7 , —COR 7 , —CO 2 R 7 , —OR 7  or —S(O) n R 13  wherein C 1 -C 4  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 3 -C 4  cycloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —NR 6 R 7 ; 
     R 2  is H; 
     R 3  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl or aryl, wherein C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl or C 3 -C 6  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —CO 2 R 7 , —NR 8 COR 7 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7  and aryl; 
     R 4  is H, allyl, or C 1 -C 4  alkyl, wherein C 1 -C 4  alkyl is optionally substituted with C 1 -C 4  alkyl, —OR 7 , —S(O) 2 R 12 , —CO 2 R 7 , —NR 6 R 7  or —NR 9 COR 10 ; 
     R 5  is independently selected at each occurrence from C 1 -C 6  alkyl, aryl, heterocyclyl, C 1 -C 4  haloalkyl, halo, —CN, —NO 2 , —NR 6 R 7 , —COR 7 , —OR 7 , —CONR 6 R 7 , —CON(OR 9 )R 7 , —CO 2 R 7  and —S(O) n R 13 , wherein C 1 -C 6  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, —NO 2 , halo, —CN, —NR 6 R 7 , COR 7 , —OR 7 , —CONR 6 R 7 , CO 2 R 7  and —S(O) n R 13 ; 
     R 6  and R 7  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl and C 2 -C 8  alkoxyalkyl; wherein C 1 -C 4  alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from —OH or C 1 -C 4  alkoxy groups; 
     R 8 , R 9  and R 10  are independently at each occurrence H or C 1 -C 4  alkyl; 
     R 12  and R 13  are independently at each occurrence C 1 -C 4  alkyl or —NR 6 R 7 ; 
     R 14  is C 1 -C 4  alkyl or —NR 15 R 16 ; 
     R 15  and R 16  are independently at each occurrence H, C 1 -C 4  alkyl or C 2 -C 8  alkoxyalkyl; 
     aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —NO 2  and —NR 15 R 16 ; and 
     n is independently at each occurrence 0, 1 or 2. 
     [5] Even more preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein: 
     Z is CR 2 ; 
     Y is NR 4 ; 
     Ar is phenyl or pyridyl, each substituted with 2 to 4 R 5  groups; 
     R 1  is H, Cl, Br, methyl, ethyl, cyclopropyl, or —CN, 
     R 2  is H; 
     R 3  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl or aryl, wherein C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl or C 3 -C 6  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, —CF 3 , halo, —CN, —OR 7 , and aryl; 
     R 4  is H, methyl, ethyl, i-propyl, n-propyl, n-butyl, i-butyl, s-butyl, n-butyl, or allyl; 
     R 5  is independently selected at each occurrence from methyl, ethyl, i-propyl, n-propyl, aryl, —CF 3 , halo, —CN, —N(CH 3 ) 2 , —C(═O)CH 3 , —OCH 3 , —OCH 2 CH 3 , —OCF 3 , and —S(O) 2 CH 3 ; 
     R 14  is C 1 -C 4  alkyl or —NR 15 R 16 ; 
     R 15  and R 16  are independently at each occurrence H, C 1 -C 4  alkyl or C 2 -C 8  alkoxyalkyl; 
     aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —NO 2  and —NR 15 R 16 ; and 
     n is independently at each occurrence 0, 1 or 2. 
     [6] Specifically preferred compounds of this invention are compounds of Formula (I), pharmaceutically acceptable salts and pro-drug forms thereof, which are: 
     3-[(2,4-Dibromophenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone; 
     3-[[2-Bromo-4-(1-methylethyl)phenyl]amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone; 
     3-[(2,4-Dibromophenyl)ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone; 
     3-[[2-Bromo-4-(1-methylethyl)phenyl]ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone; 
     3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone; 
     3-[(2,4,6-Trimethylphenyl)ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     3-[(2-Bromo-4,6-dimethoxyphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone; 
     3-[(2-Cyano-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2-Bromo-4,6-dimethoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2-Chloro-4,6-dimethoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(4,6-Dimethyl-2-iodophenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     3-[(2-Cyano-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2-Bromo-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(4-Acetyl-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2-Acetyl-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(4,6-Dimethyl-2-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(4,6-Dimethyl-2-methylsulfonylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(4-Chloro-2-iodo-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-phenyl-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4-Dibromophenyl)amino]-5-methyl-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[[2-Bromo-4-(1-methylethyl)phenyl]amino]-5-methyl-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(2,4-Dichloro-6-methylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(2,4-Dichloro-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(2,4-Dibromo-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(2-methoxyethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[[2,4-Dimethyl-6-(methoxymethyl)phenyl]amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     (+/−)3-[(2,4-Dimethyl-6-methoxyphenyl)amino]-5-chloro-1-(2-methoxy-1-methylethyl)-2(1H)-pyrazinone; 
     (+/−)3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-(2-methoxy-1-methylethyl)-2(1H)-pyrazinone; 
     (+/−)3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(ethoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-(2-ethoxy-1-methylethyl)-2(1H)-pyrazinone; and 
     (+/−)3-[(4-Bromo-2,6-difluorophenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2-Bromo-4,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4-Dimethyl-6-thiomethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4-Dimethyl-6-methylsulfonylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,6-Dimethyl-4-(N,N-dimethylamino)phenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,4-Dichloro-6-methylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(4-Chloro-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,6-Dimethyl-4-methoxyphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     (+/−)-3-[(4-Acetyl-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone; 
     3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(4-Acetyl-2,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(2,6-Dimethyl-4-(N,N-dimethylamino)phenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(4,6-Dimethyl-2-(N,N-dimethylamino)phenyl)amino]-5-methyl-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     (+/−)3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     (+/−)3-[(4-Bromo-6-methoxy-2-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone; 
     3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(2,6-Dimethyl-4-methylsulfonylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; 
     3-[(4-Bromo-6-methoxy-2-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone; and 
     3-[(2,4,6-Trimethylphenyl)amino]-5-methyl-1-(1-ethylpropyl)-2(1H)-pyrazinone. 
     [7] A second embodiment of preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein: 
     Z is CR 2 ; 
     Y is NR 4  or O; 
     Ar is phenyl or pyridyl, each substituted with 0 to 4 R 5  groups; 
     R 1  is H, halo, C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 8  cycloalkyl, C 1 -C 4  haloalkyl, aryl, heterocyclyl, —CN, —OR 7 , —SH, —S(O) n R 13 , —COR 7 , —CONR 6 R 7 , —CO 2 R 7 , —OC(O)R 13 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , or —NR 6 R 7 , wherein C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl or C 3 -C 8  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, halo, C 1 -C 4  haloalkyl, —CN, —OR 7 , —SH, —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —OC(O)R 13 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7 , —CONR 6 R 7 , aryl and heterocyclyl; 
     R 2  is H, C 1 -C 4  alkyl, halo, C 1 -C 4  haloalkyl; 
     R 3  is C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl and —NR 6 R 7 , wherein C 1 -C 4  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7  and —CONR 6 R 7 ; 
     R 4  is H, C 1 -C 6  alkyl or C 2 -C 6  alkenyl, wherein C 1 -C 6  alkyl is optionally substituted with C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, —OR 7 , —S(O) n R 12 , —CO 2 R 7 , —NR 6 R 7  or —NR 9 COR 10 ; 
     R 5  is independently selected at each occurrence from C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, aryl, heterocyclyl, —NO 2 , halo, —CN, C 1 -C 4  haloalkyl, —NR 6 R 7 , —NR 8 COR 7 , —NR 8 CO 2 R 7 , —OR 7 , —COR 7 , —CO 2 R 7 , —CONR 6 R 7 , —CON(OR 9 )R 7  and —S(O) n R 13 , wherein C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 6  cycloalkyl and C 4 -C 12  cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, —NO 2 , halo, —CN, —OR 7 , —COR 7 , —CO 2 R 7 , —CONR 6 R 7 , —NR 6 R 7 , —NR 8 COR 7 , —NR 8 CO 2 R 7  and —S(O) n R 13 ; 
     R 6  and R 7  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, aryl, aryl(C 1 -C 4  alkyl)-, heterocyclyl, heterocyclyl (C 1 -C 4  alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or —NR 6 R 7  taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine; wherein C 1 -C 4  alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from —OH or C 1 -C 4  alkoxy groups; 
     R 8  is independently at each occurrence H or C 1 -C 4  alkyl; 
     R 9  and R 10  are independently at each occurrence selected from H, C 1 -C 4  alkyl and C 3 -C 6  cycloalkyl; 
     R 11  is H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, or C 3 -C 6  cycloalkyl; 
     R 12  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl or —NR 6 R 7 ; 
     R 13  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, —NR 6 R 7 , aryl, aryl(C 1 -C 4  alkyl)-, heterocyclyl or heterocyclyl(C 1 -C 4  alkyl)-; 
     R 14  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, —NR 15 R 16 ; 
     R 15  and R 16  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl and C 4 -C 12  cycloalkylalkyl; or —NR 15 R 16  taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine; 
     aryl is phenyl or naphthyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —NO 2 , —NR 8 COR 15 , —NR 8 CONR 15 R 16 , —NR 8 CO 2 R 15  and —NR 15 R 16 ; 
     heterocyclyl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —CO 2 R 15 , —NO 2 , —NR 8 COR 15 , —NR 8 CONR 15 R 16 , —NR 8 CO 2 R 15 , and —NR 15 R 16 ; and 
     n is independently at each occurrence 0, 1 or 2. 
     [8] More preferred compounds of the second embodiment of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein: 
     Z is CR 2 ; 
     Y is NR 4 ; 
     Ar is phenyl or pyridyl, each substituted with 0 to 4 R 5  groups; 
     R 1  is H, halo, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, aryl, heterocyclyl, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CONR 6 R 7 , —CO 2 R 7  or —NR 6 R 7 , wherein C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl or C 3 -C 6  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, halo, C 1 -C 4  haloalkyl, —CN, —OR 7 , —SH, —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —OC(O)R 13 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7 , —CONR 6 R 7 , aryl and heterocyclyl; 
     R 2  is H; 
     R 3  is C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl and —NR 6 R 7 , wherein C 1 -C 4  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7  and —CONR 6 R 7 ; 
     R 4  is H, allyl, or C 1 -C 4  alkyl, wherein C 1 -C 4  alkyl is optionally substituted with C 1 -C 4  alkyl, —OR 7 , —S(O) 2 R 12 , —CO 2 R 7 , —NR 6 R 7  or —NR 9 COR 10 ; 
     R 5  is independently selected at each occurrence from C 1 -C 6  alkyl, aryl, heterocyclyl, C 1 -C 4  haloalkyl, halo, —CN, —NO 2 , —NR 6 R 7 , —COR 7 , —OR 7 , —CONR 6 R 7 , —CON(OR 9 )R 7 , —CO 2 R 7  and —S(O) n R 13 , wherein C 1 -C 6  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, —NO 2 , halo, —CN, —NR 6 R 7 , COR 7 , —OR 7 , —CONR 6 R 7 , CO 2 R 7  and —S(O) n R 13 ; 
     R 6  and R 7  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl and C 2 -C 8  alkoxyalkyl; wherein C 1 -C 4  alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from —OH or C 1 -C 4  alkoxy groups; 
     R 8 , R 9  and R 10  are independently at each occurrence H or C 1 -C 4  alkyl; 
     R 12  and R 13  are independently at each occurrence C 1 -C 4  alkyl or —NR 6 R 7 ; 
     R 14  is C 1 -C 4  alkyl or —NR 15 R 16 ; 
     R 15  and R 16  are independently at each occurrence H, C 1 -C 4  alkyl or C 2 -C 8  alkoxyalkyl; 
     aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —NO 2  and —NR 15 R 16 ; and 
     n is independently at each occurrence 0, 1 or 2. 
     [10] A third embodiment of preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein: 
     Z is N; 
     Y is NR 4  or O; 
     Ar is phenyl or pyridyl, each substituted with 0 to 4 R 5  groups; 
     R 1  is H, halo, C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, aryl, —CN, C 1 -C 4  haloalkyl, —NR 6 R 7 , —CONR 6 R 7 , —OR 7 , —COR 7 , —CO 2 R 7  or —S(O) n R 13 , wherein C 1 -C 4  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —NR 8 COR 7 , —NR 8 CO 2 R 7 , —NR 6 R 7  and aryl; 
     R 3  is C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 8  cycloalkyl, C 1 -C 4  haloalkyl, aryl, heterocyclyl, —CN, —S(O) 2 R 13 , —COR 7 , —CO 2 R 7  or —CONR 6 R 7 , wherein C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl or C 3 -C 8  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —CO 2 R 7 , —NR 8 COR 7 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7 , aryl and heterocyclyl; 
     R 4  is H, C 1 -C 6  alkyl or C 2 -C 6  alkenyl, wherein C 1 -C 6  alkyl is optionally substituted with C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, —OR 7 , —S(O) n R 12 , —CO 2 R 7 , —NR 6 R 7  or —NR 9 COR 10 ; 
     R 5  is independently selected at each occurrence from C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 4 -C 8  cycloalkylalkyl, aryl, heterocyclyl, C 1 -C 4  haloalkyl, halo, —CN, —NO 2 , —NR 6 R 7 , —COR 7 , —OR 7 , —CONR 6 R 7 , —CON(OR 9 )R 7 , CO 2 R 7  and —S(O) n R 13 , wherein C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl and C 4 -C 8  cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, —NO 2 , halo, —CN, —NR 6 R 7 , COR 7 , —OR 7 , —CONR 6 R 7 , CO 2 R 7  and —S(O) n R 13 ; 
     R 6  and R 7  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, aryl, aryl(C 1 -C 4  alkyl)-, heterocyclyl, heterocyclyl(C 1 -C 4  alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or —NR 6 R 7  taken together as a whole is piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine or thiomorpholine; wherein C 1 -C 4  alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from —OH or C 1 -C 4  alkoxy groups; 
     R 8  is independently at each occurrence H or C 1 -C 4  alkyl; 
     R 9  and R 10  are independently at each occurrence selected from H, C 1 -C 4  alkyl and C 3 -C 6  cycloalkyl; 
     R 11  is H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, or C 3 -C 6  cycloalkyl; 
     R 12  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl or —NR 6 R 7 ; 
     R 13  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, —NR 6 R 7 , aryl, aryl(C 1 -C 4  alkyl)-, heterocyclyl or heterocyclyl(C 1 -C 4  alkyl)-; 
     R 14  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, —NR 15 R 16 ; 
     R 15  and R 16  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl and C 4 -C 12  cycloalkylalkyl; or —NR 15 R 16  taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine; 
     aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —NO 2 , —NR 8 COR 15 , —NR 8 CONR 15 R 16 , —NR 8 CO 2 R 15  and —NR 15 R 16 ; 
     heterocyclyl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —CO 2 R 15 , —NO 2 , —NR 8 COR 15 , —NR 8 CONR 15 R 16 , —NR 8 CO 2 R 15 , and —NR 15 R 16 ; and 
     n is independently at each occurrence 0, 1 or 2. 
     [11] More preferred compounds of the third embodiment of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein: 
     Z is N; 
     Y is NR 4 ; 
     Ar is phenyl or pyridyl, each substituted with 0 to 4 R 5  groups; 
     R 1  is H, halo, C 1 -C 4  alkyl, C 1 -C 3  haloalkyl, cyclopropyl, —CN, —NR 6 R 7 , —CONR 6 R 7 , —COR 7 , —CO 2 R 7 , —OR 7  or —S(O) n R 13  wherein C 1 -C 4  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 3 -C 4  cycloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —NR 6 R 7 ; 
     R 3  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl or aryl, wherein C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl or C 3 -C 6  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —CO 2 R 7 , —NR 8 COR 7 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7  and aryl; 
     R 4  is H, allyl, or C 1 -C 4  alkyl, wherein C 1 -C 4  alkyl is optionally substituted with C 1 -C 4  alkyl, —OR 7 , —S(O) 2 R 12 , —CO 2 R 7 , —NR 6 R 7  or —NR 9 COR 10 ; 
     R 5  is independently selected at each occurrence from C 1 -C 6  alkyl, aryl, heterocyclyl, C 1 -C 4  haloalkyl, halo, —CN, —NO 2 , —NR 6 R 7 , —COR 7 , —OR 7 , —CONR 6 R 7 , —CON(OR 9 )R 7 , —CO 2 R 7  and —S(O) n R 13 , wherein C 1 -C 6  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, —NO 2 , halo, —CN, —NR 6 R 7 , COR 7 , —OR 7 , —CONR 6 R 7 , CO 2 R 7  and —S(O) n R 13 ; 
     R 6  and R 7  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl and C 2 -C 8  alkoxyalkyl; wherein C 1 -C 4  alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from —OH or C 1 -C 4  alkoxy groups; 
     R 8 , R 9  and R 10  are independently at each occurrence H or C 1 -C 4  alkyl; 
     R 12  and R 13  are independently at each occurrence C 1 -C 4  alkyl or —NR 6 R 7 ; 
     R 14  is C 1 -C 4  alkyl or —NR 15 R 16 ; 
     R 15  and R 16  are independently at each occurrence H, C 1 -C 4  alkyl or C 2 -C 8  alkoxyalkyl; 
     aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —NO 2  and —NR 15 R 16 ; and 
     n is independently at each occurrence 0, 1 or 2. 
     [12] Even more preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein: 
     Z is N; 
     Y is NR 4 ; 
     Ar is phenyl or pyridyl, each substituted with 2 to 4 R 5  groups; 
     R 1  is H, methyl, ethyl, cyclopropyl, —CF 3 , or —N(CH 3 ) 2 ; 
     R 3  is C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl or aryl, wherein C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl or C 3 -C 6  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, —CF 3 , halo, —CN, —OR 7 , and aryl; 
     R 4  is H, methyl, ethyl, i-propyl, n-propyl, n-butyl, i-butyl, s-butyl, n-butyl, or allyl; 
     R 5  is independently selected at each occurrence from methyl, ethyl, i-propyl, n-propyl, aryl, —CF 3 , halo, —CN, —N(CH 3 ) 2 , —C(═O)CH 3 , —OCH 3 , —OCH 2 CH 3 , —OCF 3 , and —S(O) 2 CH 3 ; 
     R 14  is C 1 -C 4  alkyl or —NR 15 R 16 ; 
     R 15  and R 16  are independently at each occurrence H, C 1 -C 4  alkyl or C 2 -C 8  alkoxyalkyl; 
     aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —NO 2  and —NR 15 R 16 ; and 
     n is independently at each occurrence 0, 1 or 2. 
     [13] A fourth embodiment of preferred compounds of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein: 
     Z is N; 
     Y is NR 4  or O; 
     Ar is phenyl or pyridyl, each substituted with 0 to 4 R 5  groups; 
     R 1  is H, halo, C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 8  cycloalkyl, C 1 -C 4  haloalkyl, aryl, heterocyclyl, —CN, —OR 7 , —SH, —S(O) n R 13 , —COR 7 , —CONR 6 R 7 , —CO 2 R 7 , —OC(O)R 13 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , or —NR 6 R 7 , wherein C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl or C 3 -C 8  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, halo, C 1 -C 4  haloalkyl, —CN, —OR 7 , —SH, —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —OC(O)R 13 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7 , —CONR 6 R 7 , aryl and heterocyclyl; 
     R 3  is C 1 -C 4  alkyl, —CN, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, —OR 7 , —COR 7 , —CO 2 R 7  or —CONR 6 R 7 , wherein C 1 -C 4  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7  and —CONR 6 R 7 ; 
     R 4  is H, C 1 -C 6  alkyl or C 2 -C 6  alkenyl, wherein C 1 -C 6  alkyl is optionally substituted with C 1 -C 4  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, —OR 7 , —S(O) n R 12 , —CO 2 R 7 , —NR 6 R 7  or —NR 9 COR 10 ; 
     R 5  is independently selected at each occurrence from C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, aryl, heterocyclyl, —NO 2 , halo, —CN, C 1 -C 4  haloalkyl, —NR 6 R 7 , —NR 8 COR 7 , —NR 8 CO 2 R 7 , —OR 7 , —COR 7 , —CO 2 R 7 , —CONR 6 R 7 , —CON(OR 9 )R 7  and —S(O) n R 13 , wherein C 1 -C 10  alkyl, C 2 -C 10  alkenyl, C 2 -C 10  alkynyl, C 3 -C 6  cycloalkyl and C 4 -C 12  cycloalkylalkyl are substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, —NO 2 , halo, —CN, —OR 7 , —COR 7 , —CO 2 R 7 , —CONR 6 R 7 , —NR 6 R 7 , —NR 8 COR 7 , —NR 8 CO 2 R 7  and —S(O) n R 13 ; 
     R 6  and R 7  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, aryl, aryl(C 1 -C 4  alkyl)-, heterocyclyl, heterocyclyl(C 1 -C 4  alkyl)-, morpholinoethyl, morpholinopropyl and morpholinobutyl; or NR 6 R 7  taken together as a whole is piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine or thiomorpholine; wherein C 1 -C 4  alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from —OH or C 1 -C 4  alkoxy groups; 
     R 8  is independently at each occurrence H or C 1 -C 4  alkyl; 
     R 9  and R 10  are independently at each occurrence selected from H, C 1 -C 4  alkyl and C 3 -C 6  cycloalkyl; 
     R 11  is H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, or C 3 -C 6  cycloalkyl; 
     R 12  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl or —NR 6 R 7 ; 
     R 13  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, —NR 6 R 7 , aryl, aryl(C 1 -C 4  alkyl)-, heterocyclyl or heterocyclyl(C 1 -C 4  alkyl)-; 
     R 14  is C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl, C 4 -C 12  cycloalkylalkyl, —NR 15 R 16 ; 
     R 15  and R 16  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, C 2 -C 8  alkoxyalkyl, C 3 -C 6  cycloalkyl and C 4 -C 12  cycloalkylalkyl; or —NR 15 R 16  taken together as a whole is piperidine, pyrrolidine, piperazine, N-methyl-piperazine, morpholine or thiomorpholine; 
     aryl is phenyl or naphthyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —NO 2 , —NR 8 COR 15 , —NR 8 CONR 15 R 16 , —NR 8 CO 2 R 15  and —NR 15 R 16 ; 
     heterocyclyl is pyridyl, pyrimidinyl, triazinyl, furanyl, thienyl, imidazolyl, thiazolyl, pyrrolyl, oxazolyl, isoxazolyl or pyrazolyl, each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —CO 2 R 15 , —NO 2 , —NR 8 COR 15 , —NR 8 CONR 15 R 16 , —NR 8 CO 2 R 15 , and —NR 15 R 16 ; and 
     n is independently at each occurrence 0, 1 or 2. 
     [14] More preferred compounds of the fourth embodiment of this invention are compounds of Formula (I) and pharmaceutically acceptable salts and pro-drug forms thereof, wherein: 
     Z is N; 
     Y is NR 4 ; 
     Ar is phenyl or pyridyl, each substituted with 0 to 4 R 5  groups; 
     R 1  is H, halo, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, aryl, heterocyclyl, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CONR 6 R 7 , —CO 2 R 7  or —NR 6 R 7 , wherein C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl or C 3 -C 6  cycloalkyl is each substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, halo, C 1 -C 4  haloalkyl, —CN, —OR 7 , —SH, —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —OC(O)R 13 , —NR 8 COR 7 , —N(COR 7 ) 2 , —NR 8 CONR 6 R 7 , —NR 8 CO 2 R 7 , —NR 6 R 7 , —CONR 6 R 7 , aryl and heterocyclyl; 
     R 3  is C 1 -C 4  alkyl, —CN, C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, —OR 7 , —COR 7  or —CO 2 R 7 , wherein C 1 -C 4  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 3 -C 6  cycloalkyl, C 1 -C 4  haloalkyl, halo, —CN, —OR 7 , —S(O) n R 13 , —COR 7 , —CO 2 R 7 , —NR 8 COR 7 , —NR 6 R 7  and —CONR 6 R 7 ; 
     R 4  is H, allyl, or C 1 -C 4  alkyl, wherein C 1 -C 4  alkyl is optionally substituted with C 1 -C 4  alkyl, —OR 7 , —S(O) 2 R 12 , —CO 2 R 7 , —NR 6 R 7  or —NR 9 COR 10 ; 
     R 5  is independently selected at each occurrence from C 1 -C 6  alkyl, aryl, heterocyclyl, C 1 -C 4  haloalkyl, halo, —CN, —NO 2 , —NR 6 R 7 , —COR 7 , —OR 7 , —CONR 6 R 7 , —CON(OR 9 )R 7 , —CO 2 R 7  and —S(O) n R 13 , wherein C 1 -C 6  alkyl is substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, —NO 2 , halo, —CN, —NR 6 R 7 , COR 7 , —OR 7 , —CONR 6 R 7 , CO 2 R 7  and —S(O) n R 13 ; 
     R 6  and R 7  are independently selected at each occurrence from H, C 1 -C 4  alkyl, C 1 -C 4  haloalkyl and C 2 -C 8  alkoxyalkyl; wherein C 1 -C 4  alkyl, may be substituted with 0 to 2 substituents independently selected at each occurrence from —OH or C 1 -C 4  alkoxy groups; 
     R 8 , R 9  and R 10  are independently at each occurrence H or C 1 -C 4  alkyl; 
     R 12  and R 13  are independently at each occurrence C 1 -C 4  alkyl or —NR 6 R 7 ; 
     R 14  is C 1 -C 4  alkyl or —NR 15 R 16 ; 
     R 15  and R 16  are independently at each occurrence H, C 1 -C 4  alkyl or C 2 -C 8  alkoxyalkyl; 
     aryl is phenyl substituted with 0 to 3 substituents independently selected at each occurrence from C 1 -C 4  alkyl, halo, —CN, —OR 15 , —S(O) n R 14 , —COR 15 , —CO 2 R 15 , —NO 2  and —NR 15 R 16 ; and 
     n is independently at each occurrence 0, 1 or 2. 
     A fifth embodiment of this invention is the method of treating affective disorders, anxiety, depression, post-traumatic stress disorders, supranuclear palsy, seizure disorders, stroke, irritable bowel syndrome, immune suppression, Alzheimer&#39;s disease, gastrointestinal disease, anorexia nervosa or other eating disorders, drug or alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems in a mammal in need of such treatment comprising administering to the mammal a therapeutically effective amount of a compound of Formula I. 
     A sixth embodiment of this invention are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of Formula I. 
     This invention also includes intermediate compounds useful in preparation of the CRF antagonist compounds and processes for making those intermediates, as described in the following description and claims. 
     The CRF antagonist compounds provided by this invention (and especially labelled compounds of this invention) are also useful as standards and reagents in determining the ability of a potential pharmaceutical to bind to the CRF receptor. 
     DETAILED DESCRIPTION OF INVENTION 
     Many compounds of this invention have one or more asymmetric centers or planes. Unless otherwise indicated, all chiral (enantiomeric and diastereomeric) and racemic forms are included in the present invention. Many geometric isomers of olefins, C═N double bonds, and the like can also be present in the compounds, and all such stable isomers are contemplated in the present invention. The compounds may be isolated in optically active or racemic forms. It is well known in the art how to prepare optically active forms, such as by resolution of racemic forms or by synthesis from optically active starting materials. All chiral, (enantiomeric and diastereomeric) and racemic forms and all geometric isomeric forms of a structure are intended, unless the specific stereochemistry or isomer form is specifically indicated. 
     The term “alkyl” includes both branched and straight-chain alkyl having the specified number of carbon atoms. For example, the term “C 1 -C 10  alkyl” denotes alkyl having 1 to 10 carbon atoms; thus, methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl, wherein, for example, butyl can be —CH 2 CH 2 CH 2 CH 3 , —CH 2 CH(CH 3 ) 2 , —CH(CH 3 )CH 2 CH 3  or —CH(CH 3 ) 3 . 
     The term “alkenyl” includes hydrocarbon chains of either a straight or branched configuration and one or more unsaturated carbon—carbon bonds which may occur in any stable point along the chain. For example, the term “C 2 -C 10  alkenyl” denotes alkenyl having 2 to 10 carbon atoms; thus, ethenyl, propenyl, butenyl, pentenyl, hexenyl, heptenyl, octenyl, nonenyl and decenyl, such as allyl, propargyl, 1-buten-4-yl, 2-buten-4-yl and the like, wherein, for example, butenyl can be, but is not limited to, —CH═CH 2 CH 2 CH 3 , —CH 2 CH═CHCH 3 , —CH 2 CH 2 CH═CH 2 , —CH═C(CH 3 ) 2  or —CH═CHCH═CH 2 . 
     The term “alkynyl” includes hydrocarbon chains of either a straight or branched configuration and one or more triple carbon—carbon bonds which may occur in any stable point along the chain. The term “C 2 -C 10  alkynyl” denotes alkynyl having 2 to 10 carbon atoms; thus, ethynyl, propynyl, butynyl, pentynyl, hexynyl, heptynyl, octynyl, nonynyl and decynyl. 
     The term “haloalkyl” is intended to include both branched and straight-chain alkyl having the specified number of carbon atoms, substituted independently with 1 or more halogen, such as, but not limited to, —CH 2 F, —CHF 2 , —CF 3 , —CF 2 Br, —CH 2 CF 3 , —CF 2 CF 3 , —CH(CF 3 ) 2  and the like. 
     The term “alkoxy” represents an alkyl group of indicated number of carbon atoms attached through an oxygen bridge. 
     The term “cycloalkyl” is intended to include saturated ring groups having the specified number of carbon atoms, including mono-, bi- or poly-cyclic ring systems, such as cyclopropyl (c-Pr), cyclobutyl (c-Bu), cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, [3.3.0]bicyclooctyl, [2.2.2]bicyclooctyl and so forth. 
     As used herein, the term “heterocyclyl” or “heterocyclic” is intended to mean a stable 5- to 7-membered monocyclic or bicyclic or 7- to 10-membered bicyclic heterocyclic ring which may be saturated, partially unsaturated, or aromatic, and which consists of carbon atoms and from 1 to 4 heteroatoms independently selected from the group consisting of N, O and S and wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, and the nitrogen may optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring. The heterocyclic ring may be attached to its pendant group at any heteroatom or carbon atom which results in a stable structure. The heterocyclic rings described herein may be substituted on carbon or on a nitrogen atom if the resulting compound is stable. Examples of such heterocycles include, but are not limited to, pyridyl (pyridinyl), pyrimidinyl, furanyl (furyl), thiazolyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, benzothiophenyl, indolyl, indolenyl, isoxazolinyl, isoxazolyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, 4-piperidonyl, pyrrolidinyl, 2-pyrrolidonyl, pyrrolinyl, tetrahydrofuranyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, decahydroquinolinyl or octahydroisoquinolinyl, azocinyl, triazinyl, 6H-1,2,5-thiadiazinyl, 2H,6H-1,5,2-dithiazinyl, thianthrenyl, pyranyl, isobenzofuranyl, chromenyl, xanthenyl, phenoxathiinyl, 2H-pyrrolyl, pyrrolyl, imidazolyl, pyrazolyl, isothiazolyl, isoxazolinyl, isoxazolyl, oxazolyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolizinyl, isoindolyl, 3H-indolyl, indolyl, 1H-indazolyl, purinyl, 4H-quinolizinyl, isoquinolinyl, quinolinyl, phthalazinyl, naphthyridinyl, quinoxalinyl, quinazolinyl, cinnolinyl, pteridinyl, 4aH-carbazole, carbazole, β-carbolinyl, phenanthridinyl, acridinyl, perimidinyl, phenanthrolinyl, phenazinyl, phenarsazinyl, phenothiazinyl, furazanyl, phenoxazinyl, isochromanyl, chromanyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyrazolinyl, piperidinyl, piperazinyl, indolinyl, isoindolinyl, quinuclidinyl, morpholinyl, oxazolidinyl, benzothienyl, 2,3-dihydrobenzofuranyl or 2,3-dihydrobenzothienyl. 
     The term “halo” or “halogen” includes fluoro, chloro, bromo and iodo. 
     The term “substituted”, as used herein, means that one or more hydrogen on the designated atom is replaced with a selection from the indicated group, provided that the designated atom&#39;s normal valency is not exceeded, and that the substitution results in a stable compound. When a substituent is keto (i.e., ═O), then 2 hydrogens on the atom are replaced. 
     Combinations of substituents and/or variables are permissible only if such combinations result in stable compounds. By “stable compound” or “stable structure” is meant a compound that is sufficiently robust to survive isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent. 
     The term “pharmaceutically acceptable salts” includes acid or base salts of the compounds of formula (I). Examples of pharmaceutically acceptable salts include, but are not limited to, mineral or organic acid salts of basic residues such as amines; alkali or organic salts of acidic residues such as carboxylic acids; and the like. 
     Pharmaceutically acceptable salts of the compounds of the invention can be prepared by reacting the free acid or base forms of these compounds with a stoichiometric amount of the appropriate base or acid in water or in an organic solvent, or in a mixture of the two; generally, nonaqueous media like ether, ethyl acetate, ethanol, isopropanol, or acetonitrile are preferred. Lists of suitable salts are found in  Remington&#39;s Pharmaceutical Sciences,  17th ed., Mack Publishing Company, Easton, Pa., 1985, p. 1418, the disclosure of which is hereby incorporated by reference. 
     “Prodrugs” are considered to be any covalently bonded carriers which release the active parent drug of formula (I) in vivo when such prodrug is administered to a mammalian subject. Prodrugs of the compounds of formula (I) are prepared by modifying functional groups present in the compounds in such a way that the modifications are cleaved, either in routine manipulation or in vivo, to the parent compounds. Prodrugs include compounds wherein hydroxy, amine, or sulfhydryl groups are bonded to any group that, when administered to a mammalian subject, cleaves to form a free hydroxyl, amino, or sulfhydryl group, respectively. Examples of prodrugs include, but are not limited to, acetate, formate and benzoate derivatives of alcohol and amine functional groups in the compounds of formula (I); and the like. 
     The term “therapeutically effective amount” of a compound of this invention means an amount effective to antagonize abnormal level of CRF or treat the symptoms of affective disorder, anxiety or depression in a host. 
     Synthesis 
     The pyrazinones and triazinones of this invention can be prepared by one of the general schemes outlined below (Scheme 1-6). 
     Compounds of the Formula (I) wherein Z=CH, Y=NR 4 , R 1 =halogen and R 2 =H can be prepared as shown in Scheme 1. Compounds wherein R 2  is a substituent other than H as defined in the broad scope of the invention can also be prepared as shown in Scheme 1 by using the corresponding R 2 COH substituted aldehydes or ClCHR 2 CN substituted haloacetonitriles.                           
     Reaction of a cyanide salt with formaldehyde and the appropriate substituted amine afforded the corresponding aminoacetonitrile which was purified as the hydrochloride salt of Formula (III). Alternatively the same compounds of Formula (III) can be synthesized by reaction of the amine H 2 NR 3  with a haloacetonitrile, such as chloroacetonitrile, in the presence of a base such as a tertiary amine or an inorganic base such as K 2 CO 3  in an organic solvent and isolated as a salt of an inorganic acid by treatment with that acid. Amine salt of Formula (III) was treated with an oxalyl halide, R 1 COCOR 1 , such as oxalyl chloride or bromide to afford the dihalo compound Formula (IV), as described in Vekemans, J.; Pollers-Wieers, C.; Hoornaert, G.  J. Heterocyclic Chem.  20, 919, (1982). Compound Formula (IV) can be coupled with an aryl amine H 2 NAr thermally, in the presence of a strong base such as NaH, KN(SiMe 3 ) 2 , LiN(SiMe 3 ) 2  or NaN(SiMe 3 ) 2  in an aprotic organic solvent, or under acid catalysis to give compounds of Formula (V). Compounds of Formula (V) can be alkylated with an alkyl halide R 4 X to afford compounds of Formula (I). 
     Compounds where R 1 =alkyl or substituted alkyl can be prepared according to Scheme 2.                           
     Reaction of the intermediate of Formula (IV) in Scheme 1, wherein R 1 =X=halogen in Scheme 2, with an alkyl or aryl thiol, HSR″, in the presence of base such as NaH affords the adduct of Formula (VII), which may then be treated with a trialkylaluminum as described in Hirota, K.; Kitade, Y.; Kanbe, Y.; Maki, Y.;  J. Org. Chem.  57, 5268, (1992), in the presence of a palladium catalyst, such as Pd(PPh 3 ) 2 Cl 2 , to give compounds of Formula (VIII). Condensation of compounds of Formula (VIII) with an aryl amine H 2 NAr under thermal, base, or acid catalyzed conditions gives compounds of Formula (IX). Alternatively (VIII) may be oxidized to the corresponding sulfones with an oxidant such as KMnO 4  and then condensed with the arylamines of formula H 2 NAr to give (IX). The use of appropriately substituted aluminum alkyls, or simple transformations of those substituted alkyls can give access to compounds of Formula (I), where R 1  is a substituted alkyl; see Ratovelomanana, V.; Linstrumelle, G.;  Tet. Letters  52, 6001 (1984) and references cited therein. 
     Compounds of the Formula (I) wherein Z=CH, Y=O or S(O) n  and R 1 =halogen can be prepared as shown in Scheme 3.                           
     Reaction of the dihalo intermediate (IV) from Scheme 1 with a phenoxide or thiophenoxide, formed by treatment of the corresponding phenol or thiophenol with an appropriate base, such as NaH in an aprotic solvent, gives the adduct of Formula (X) or (XI). Adduct (XI) may be further oxidized to the sulfoxide or sulfone of Formula (XII), by treatment with the appropriate oxidant, such as a peroxide, NaIO4 or KMnO4. 
     Compounds of Formula (I) where R 1 =OR, SR and S(O) n R and Z=CH can be introduced on compounds of Formula (V) by copper or copper salt-catalyzed coupling of the corresponding anions RO −  and RS −  with the pyrazinone bromide. Keegstra, M. A.; Peters, T. H. A.; Brandsma, L.;  Tetrahedron,  48, 3633 (1992) describes the addition of phenoxide anions by this method; alternatively, the same conditions can be used for the addition of thiophenoxide anions. Alternatively the same compounds can be synthesized by Scheme 4.                           
     In Scheme 4, reaction of an aminoacetonitrile salt (III), described in Scheme 1, with an oxalyl halide ester (XIII) gives the corresponding amide (XIV), which in turn can be converted to the corresponding imidate salt (XV). This can be cyclized under treatment with a base, such as K 2 CO 3  or Et 3 N to the pyrazinedione of Formula (XVI). This can be converted to the corresponding halide (XIX), using a halogenating agent such as POX 3 , oxalyl halide or SOX 2 . Alternatively, (XVI) can be converted to the corresponding mesylate, tosylate or triflate, by treatment with the corresponding mesyl, tosyl, or triflic anhydride. Subsequently, (XIX) can be coupled with an aniline to the corresponding adduct of Formula (XX), under the conditions described in Scheme 1, or (XIX) can be coupled with a phenoxide or thiophenoxide as described in Scheme 3 to yield compounds of Formula (I) wherein Y=O or S(O) n . 
     Compounds of Formula (I) wherein R 1 =substituted N and Z=CH can be introduced on compounds of Formula (XV) by reaction with an amine to form the corresponding amidate (XVII) according to Scheme 5. Subsequently, (XVII) can be cyclized, halogenated, and substituted with the appropriate aniline, phenoxide or thiophenoxide as described in Scheme 4 above. 
     Compounds of Formula I wherein Z=CH and R 1 =COR 7  or CO 2 R 7  can be synthesized from compounds of Formula (VII) by coupling with the appropriate vinyl aluminum or boron reagent in the presence of a palladium catalyst, such as Pd(PPh 3 ) 2 Cl 2 , and further transformations of the vinyl group, using methods known to one skilled in the art.                           
     The compounds of Formula (I) where Z=CH and R 1  or R 3  is a functional group not compatible with the procedures of Schemes 1-5 may be prepared from precursors where the interfering functionality of R 1  or R 3  is protected using methods known to one skilled in the art (see T. W. Green and P. G. M. Wuts,  Protecting Groups in Organic Synthesis , Wiley, New York, 1991); or from precursors bearing R 1  or R 3  groups amenable to later conversion into the desired functionality using standard methods (see J. March,  Advanced Organic Chemistry , Wiley, New York, 1992). 
     Triazinones of Formula (I) wherein Z=N and Y=NR 4 , O or S(O) n  can be prepared by the synthetic route shown in Scheme 6. 
     Condensation of a substituted hydrazine with acetamidines or imidates provides amidrazones of Formula (XXX) (Khrustalev, V. A., Zelenin, K. N. Zhurnal Organicheskoi Khimii, Vol. 15, No. 11, 1979, 2280). Cyclization of (XXX) with oxalyl derivatives such as oxalyl chloride provides diones of Formula (XXXI). Treatment of (XXXI) with chlorodehydrating agents such as thionyl chloride, oxalyl chloride or phosphorous oxychloride provides chlorotriazinones of Formula (XXXII), which may be treated with phenols, thiophenols, anilines and their heterocyclic analogs under basic, acidic or thermal conditions to provide compounds of Formula (I) where Z=N and Y=O, S or NH, respectively. In the preceding instance where Y=NH, alkylation of the nitrogen atom with e.g. alkyl iodides provides the related compounds of Formula (I) where Z=N and Y=NR 4 . In the preceding instance where Y=S, oxidation with e.g. mCPBA provides the compounds of Formula (I) where Z=N and Y=S(O) and S(O) 2 . The compounds of Formula (I) where Z=N and R 1  or R 3  is a functional group not compatible with the procedures of Scheme 4 may be prepared from precursors such as amidrazones of Formula (XXX) or substituted hydrazines where the                           
     interfering functionality of R 1  or R 3  is protected using methods known to one skilled in the art (see T. W. Green and P. G. M. Wuts,  Protecting Groups in Organic Synthesis , Wiley, New York, 1991); or from precursors bearing R 1  or R 3  groups amenable to later conversion into the desired functionality using standard methods (see J. March,  Advanced Organic Chemistry , Wiley, New York, 1992). 
     Triazinones of Formula (I) wherein Z=N and Y=NR 4 , O or S(O) n  can also be prepared by the synthetic route shown in Scheme 7.                           
     Reaction of ethyl oxalyl chloride with acylated hydrazines of Formula (XXXIV) provides the ethyl oxalyl acylhydrazine derviatives of Formula (XXXV). Compounds of Formula (XXXIV) may be arrived at via condensation of an appropriate ketone or aldehyde with an acylated hydrazide to give acylated hydrazones which may then be reduced under catalytic hydrogenation conditions or by other reducing agents to give the compounds of Formula (XXXIV). The abovementioned acylated hydrazones may also be produced by acylation of a hydrazone made from hydrazine and an appropriate ketone or aldehyde using methods known to one skilled in the art of organic synthesis. Alternatively, compounds of Formula (XXXIV) may also be produced by acylation of an appropriate hydrazine using methods known to one skilled in the art of organic synthesis. 
     The ethyl esters of compound (XXXV) may then be converted to the primary amide derivatives of Formula (XXXVI) by treatment with an ammonia source such as ammonium hydroxide. Cyclization of (XXXVI) to produce the diones of Formula (XXXI) may be achieved by treatment with, for example, iodotrimethylsilane (TMSI) or POCl 3 , or by heating in the presence of a Lewis acid such as ZnCl 2 . The oxo group in the 5 position of the 1,2,4-triazin-5,6-diones of Formula (XXXI) may then be converted to a leaving group using reagents such as trifluoromethanesulfonic anhydride under basic conditions to yield compounds of Formula (XXXVII) which may then be treated with phenols, thiophenols, anilines and their heterocyclic analogs under basic conditions to provide compounds of Formula (I). 
     Additional 1,2,4-triazinone syntheses are disclosed in the literature (A. R. Katritzky and C. W. Rees,  Comprehensive Heterocyclic Chemistry , Pergamon Press, New York, Vol. 3, 1984, p. 385) and can be prepared by one skilled in the art. 
     Intermediates, for example ArYH, H 2 NAr, HOAr or HSAr, in the synthesis of compounds of Formula (I) in Schemes 1-6 may be prepared using standard methods known to one skilled in the art (see, D. Barton and W. D. Ollis,  Comprehensive Organic Chemistry , Pergamon Press, New York, Vol. 1-6, 1979; A. R. Katritzky and C. W. Rees,  Comprehensive Heterocyclic Chemistry , Pergamon Press, New York, Vol. 1-8, 1984; B. Trost and I. Fleming,  Comprehensive Organic Synthesis , Pergamon Press, New York, Vol. 1-9, 1991; and DuPont Merck PCT application WO95/10506). 
     All of the aforementioned references are hereby incorporated by reference. 
    
    
     EXAMPLE 1 
     3-[[2-Bromo-4-(1-methylethyl)phenyl]amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone 
     Part A 
     Hydrogen chloride (12M, aq., 3.8 mL), methanol (33 mL), water (30 mL), potassium cyanide (3 g), 1-ethylpropylamine (4 g), and formaldehyde (37% w/v, 3.7 mL) were stirred 18 hours at room temperature. Water (200 mL) was added, and the mixture was extracted with 2×200 mL methylene chloride, which was dried over MgSO4 and concentrated to a light oil (5.57 g). The oil was dissolved in ether and 1N HCl was added. The precipitate was collected on paper and dried to give N-(1-ethylpropyl)aminoacetonitrile hydrochloride as an off-white solid (6.70 g). 
     Part B 
     The product from part A (2 g), chloroform (20 mL), and oxalyl chloride (4.68 g) were heated at reflux for 12 hours. The reaction was concentrated to remove excess oxalyl chloride and solvent, and the crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent to afford 3,5-dichloro-1-(1-ethylpropyl)-2(1H)-pyrazinone as a white solid (2.09 g). 
     Part C 
     The product from part B (0.68 g) and 2-bromo-4-isopropylaniline (1.24 g) were heated at 140° C. for 5 hours. After cooling, methylene chloride (20 mL) was added, filtered, and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexane (1:9) as eluent to afford the title compound. 639 mg. mp 118.5-119.5° C. Elemental analysis: calcd. for C 18 H 23 N 3 OBrCl: C, 52.38; H, 5.626; N, 10.18; Br, 19.36; Cl, 8.599. Found: C, 52.62; H, 5.43; N, 10.13; Br, 19.53; Cl, 8.97. 
     EXAMPLE 2 
     3-[[2-Bromo-4-(1-methylethyl)phenyl]ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone 
     The product from Example 1 (198 mg), N,N-dimethylformamide (5 mL), and sodium hydride (60% in oil, 96 mg) were stirred at room temperature 20 minutes. Iodoethane (112 mg) was added and the reaction was stirred overnight at room temperature and quenched with water (10 mL) and saturated sodium chloride (aq., 10 mL). The mixture was extracted with methylene chloride which was dried and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexane (1:19) as eluent to afford the title compound (125 mg). CI-HRMS calcd. for C 20 H 28 N 3 OClBr (M+H) + : 440.110427. Found: 440.107480. 
     EXAMPLE 3 
     3-[(2,4-Dibromophenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone 
     2,4-Dibromoaniline (500 mg), toluene (8 mL), and sodium hydride (60% in oil, 398 mg) were stirred for 10 minutes at room temperature and then 3,5-dichloro-1-(1-ethylpropyl)-2(1H)-pyrazinone (468 mg, Example 1, part B) was added. The reaction was heated at reflux 3 hours, cooled, and quenched with water (50 mL). The mixture was extracted with ethyl acetate (100 mL), which was washed with brine, then dried and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexane (1:19) affording 400 mg of material, which was crystallized from ether/hexane to give the title compound (240 mg). Elemental analysis: calcd. for C 15 H 16 N 3 OClBr 2 : C, 40.07; H, 3.597; N, 9.356; Cl, 7.895; Br, 35.55. Found: C, 40.41; H, 3.49; N, 9.34; Cl, 8.27; Br, 35.71. 
     EXAMPLE 4 
     3-[(2,4-Dibromophenyl)ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 2. Elemental analysis calcd. for C 17 H 20 N 3 OClBr 2 : C, 42.75; H, 4.22; N, 8.807. Found: C, 42.82; H, 4.14; N, 8.67. 
     EXAMPLE 5 
     3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C 18 H 24 N 3 OCl: C, 64.76; H, 7.256; N, 12.59. Found: C, 64.69; H, 7.03; N, 12.55. 
     EXAMPLE 6 
     3-[(2,4,6-Trimethylphenyl)ethylamino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 2. Elemental analysis calcd. for C 20 H 28 N 3 OCl: C, 66.37; H, 7.808; N, 11.61. Found: C, 66.50; H, 7.69; N, 11.51. 
     EXAMPLE 7 
     (+/−)-3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C 18 H 24 N 3 O 2 Cl: C, 61.80; H, 6.91; N, 12.01; Cl, 10.13. Found: C, 61.69; H, 7.00; N, 11.93; Cl, 9.87. 
     EXAMPLE 8 
     3-[(2-Bromo-4,6-dimethoxyphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C 17 H 21 N 3 O 3 BrCl: C, 47.40; H, 4.91; N, 9.765. Found: C, 47.06; H, 4.61; N, 9.56. 
     EXAMPLE 9 
     3-[(2-Cyano-4,6-dimethylphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone 
     Part A 
     3-[(2-Iodo-4,6-dimethylphenyl)amino]-5-chloro-1-(1-ethylpropyl)-2(1H)-pyrazinone was prepared in a manner similar to Example 3. 
     Part B 
     The product from part A (460 mg), N,N-dimethylformamide (8 mL), cuprous cyanide (97 mg), and sodium cyanide were heated at 120° C. for 18 hours and then at 130° C. for 3 hours. After cooling, ethyl acetate (100 mL) was added to the reaction which was then washed with water (50 mL) and brine (50 mL), dried, and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent. The product was then crystallized from methylene chloride/hexane to afford the title compound (235 mg). Elemental analysis calcd. for C 18 H 21 N 4 OCl: C, 62.69; H, 6.148; N, 16.25; Cl, 10.28. Found: C, 62.29; H, 6.27; N, 15.99; Cl, 10.20. 
     EXAMPLE 10 
     (+/−)-3-[(2-Bromo-4,6-dimethoxyphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C 17 H 21 N 3 O 4 BrCl: C, 45.71; H, 4.748; N, 9.416. Found: C, 45.86; H, 4.43; N, 9.26. 
     EXAMPLE 12 
     (+/−)-3-[(2-Iodo-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone 
     Part A 
     Chloroacetonitrile (3.2 mL), 2-amino-1-methoxybutane (10.32 g), and deuterochloroform (50 mL) were stirred and heated at reflux for 48 h. Methylene chloride (100 mL) and sodium hydroxide (aq., 1N, 100 mL) were added to the reaction, the layers separated, and the organic layer concentrated to an oil (3.4 g). The oil was dissolved in ether (100 mL) and HCl/ether (1N, 100 mL) was added. The precipitate was collected on paper affording N-[(1-methoxymethyl)propyl]aminoacetonitrile hydrochloride (6.86 g). 
     Part B 
     The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C 17 H 21 N 3 O 2 ClI: C, 44.22; H, 4.58; N, 9.10. Found: C, 44.26; H, 4.60; N, 9.83. 
     EXAMPLE 15 
     (+/−)-3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone 
     To (+/−)-3,5-dichloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone (300 mg) and 4-bromo-2,6-dimethylaniline (238 mg) in THF (anhydrous, 9.4 mL) at 0° C. was added sodium bis(trimethylsilyl)amide (1.0 M/THF, 2.6 mL). The mixture was stirred at 0° C. for 10 minutes. Ethyl acetate (100 mL) was added and washed with water (25 mL) and brine (25 mL). The organic layer was dried over MgSO 4  and concentrated and the crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent. The product was then crystallized from ethyl acetate/hexane to afford the title compound (419 mg). Elemental analysis calcd. for C 17 H 21 N 3 O 2 BrCl: C, 49.23; H, 5.10; N, 10.13. Found: C, 49.33; H, 5.05; N, 10.09. 
     EXAMPLE 16 
     (+/−)-3-[(4-Acetyl-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone 
     To the product of Example 15 (250 mg), bis(triphenylphosphine)palladium(II) chloride (11 mg), and tetrakis(triphenylphosphine)palladium(0) (17 mg) in a dry flask under nitrogen was added toluene (1.5 mL) and 1-ethoxyvinyl tributyl tin (260 mg). The reaction was heated at reflux 18 hours, and then concentrated in vacuo. The residue was taken up in ether (15 mL) and saturated aqueous potassium fluoride (15 mL), and filtered. The layers were separated, and the ether layer was stirred with 1N HCl (aq., 15 mL). The layers were separated and the ether layer was dried over MgSO 4  and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexane (3:7) as eluent to afford the title compound (90 mg). Elemental analysis calcd. for C 19 H 24 N 3 O 3 Cl: C, 60.39; H, 6.40; N, 11.12. Found: C, 60.51; H, 6.31; N, 11.00. 
     EXAMPLE 16a 
     (+/−)-3-[(4-Acetyl-2-methoxy-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 16. Elemental analysis calcd. for C 19 H 24 N 3 O 4 Cl: C, 57.94; H, 6.14; N, 10.67. Found: C, 57.70; H, 5.98; N, 10.41. 
     EXAMPLE 20 
     (+/−)-3-[(4-Chloro-2-iodo-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 3. Elemental analysis calcd. for C 16 H 18 N 3 O 2 Cl 2 I: C, 39.86; H, 3.76; N, 8.725. Found: C, 40.00; H, 3.69; N, 8.64. 
     EXAMPLE 21 
     3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone 
     Part A 
     To serinol (9.90 g) in DMF (200 mL) was added triethyl amine (14.6 mL) and then chlorotriphenylmethane (24.3 g). The reaction mixture was stirred at room temperature for 18 hours. Toluene (800 mL) was added and washed with water (500 mL and 250 mL) and brine (250 mL), and then dried over K 2 CO 3  and concentrated to dryness. The product was crystallized from benzene/hexane (1:1) to afford product (14.57 g). 
     Part B 
     The product from part A (14.57 g), sodium hydroxide (17.5 g), and iodomethane (8.8 mL) were stirred overnight in DMSO (220 mL) at room temperature. Water (500 mL) was added and extracted with ethyl acetate (3×250 mL). The extracts were washed with water (2×250 mL) and brine (200 mL), dried over K 2 CO 3 , and concentrated to give product (14.46 g). 
     Part C 
     The product from part B (14.46 g) and hydrogen chloride (1M/Et 2 O, 84 mL) were stirred in methanol (300 mL) at room temperature for 6 hours. The solution was washed with hexane (3×300 mL), concentrated, and co-evaporated with ethanol affording 2-amino-1,3-methoxypropane (5.69 g). 
     Part D 
     The title compound was prepared in a manner similar the product of Example 3. Elemental analysis calcd. for C 18 H 24 N 3 O 3 Cl: C, 59.09; H, 6.61; N, 11.49. Found: C, 59.27; H, 6.53; N, 11.47. 
     EXAMPLE 30a 
     (+/−)-3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-methyl-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 84. Elemental analysis calcd. for C18H24N3O2Cl: C, 61.80; H, 6.91; N, 12.01. Found: C, 61.70; H, 6.94; N, 11.56. 
     EXAMPLE 36 
     3-[(2,4,6-Trimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 19 H 26 N 3 O 3 Cl: C, 60.07; H, 6.908; N, 11.06. Found: C, 60.22; H, 7.16; N, 10.92. 
     EXAMPLE 36a 
     3-[(4-Bromo-2-methoxy-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 18 H 23 N 3 O 4 ClBr: C, 46.92; H, 5.03; N, 9.129. Found: C, 47.29; H, 5.03; N, 8.98. 
     EXAMPLE 45a 
     3-[(2-Bromo-6-flouro-4-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 16 H 18 N 3 O 3 FClBr: C, 44.21; H, 4.17; N, 9.67. Found: C, 44.35; H, 4.25; N, 9.41. 
     EXAMPLE 46a 
     3-[(2-Chloro-4-methoxy-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 17 H 20 N 3 O 4 Cl 2 : C, 50.89; H, 5.02; N, 10.47. Found: C, 50.72; H, 5.33; N, 10.37. 
     EXAMPLE 49 
     3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-3-methoxypropyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 18 H 23 N 3 O 3 ClBr: C, 48.61; H, 5.21; N, 9.457. Found: C, 48.59; H, 5.32; N, 9.45. 
     EXAMPLE 53 
     3-[(4-Bromo-2,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 17 H 21 N 3 O 3 ClBr: C, 47.40; H, 4.91; N, 9.765. Found: C, 47.52; H, 4.99; N, 9.72. 
     EXAMPLE 54 
     3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 17 H 21 N 3 O 3 Cl 2 : C, 52.86; H, 5.489; N, 10.88. Found: C, 52.89; H, 5.44; N, 10.72. 
     EXAMPLE 77 
     (+/−)-3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 18 H 24 N 3 O 2 ClS: C, 56.62; H, 6.33; N, 11.00; S, 8.405. Found: C, 56.66; H, 6.19; N, 10.89; S, 8.45. 
     EXAMPLE 79 
     (+/−)-3-[(2-Chloro-4,6-dimethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 17 H 21 N 3 O 2 Cl 2 : C, 55.14; H, 5.726; N, 11.35. Found: C, 55.27; H, 5.70; N, 11.25. 
     EXAMPLE 80 
     (+/−)-3-[(4-Bromo-6-methoxy-2-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 17 H 21 N 3 O 3 BrCl: C, 47.40; H, 4.91; N, 9.765. Found: C, 47.91; H, 4.95; N, 9.74. 
     EXAMPLE 81 
     3-[(2,6-Dimethyl-4-thiomethylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 18 H 24 N 3 O 3 ClS: C, 54.33; H, 6.08; N, 10.56; S, 8.06. Found: C, 54.48; H, 6.01; N, 10.46; S, 7.86. 
     EXAMPLE 83 
     3-[(4-Bromo-2-methoxy-6-methylphenyl)amino]-5-chloro-1-[1-(methoxymethyl)-2-methoxyethyl]-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 15. Elemental analysis calcd. for C 17 H 21 N 3 O 4 ClBr: C, 45.71; H, 4.748; N, 9.416. Found: C, 45.80; H, 4.70; N, 9.39. 
     EXAMPLE 84 
     3-[(2,4,6-Trimethylphenyl)amino]-1-(1-ethylpropyl)-5-methyl-2(1H)-pyrazinone 
     Part A 
     N-(1-ethylpropyl)aminoacetonitrile hydrochloride (1.41 g) and oxalyl bromide (2.0 M/CH 2 Cl 2 , 13 mL) were heated at reflux for 18 hours. The reaction was concentrated to remove excess oxalyl bromide and solvent, and the crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent to afford 3,5-dibromo-1-(1-ethylpropyl)-2(1H)-pyrazinone as a white solid (1.19 g). 
     Part B 
     The product from part A (133 mg) and sodium thiomethoxide (29 mg) were combined in THF (1.5 mL) and stirred at 25° C. 4 hours. More sodium thiomethoxide (29 mg) was added and the reaction was stirred for 2 hours more at room temperature. Water (20 mL) was added and extracted with CH 2 Cl 2  (2×20 mL). The organic layers were combined, dried over MgSO 4 , and concentrated. The crude product was chromatographed on silica gel using ethyl acetate/hexanes (1:4) as eluent to afford 5-bromo-1-(1-ethylpropyl)-3-thiomethyl-2(1H)-pyrazinone (78 mg). 
     Part C 
     The product from part B (200 mg) and Pd(PPh 3 ) 2 Cl 2  (40 mg) were combined in dry THF (6 mL) under inert atmosphere (N 2 ). To that a 2M solution AlMe 3  in hexanes (0.5 mL) was added and the reaction was heated at reflux for one hour. The excess AlMe 3  was quenched with water at 0° C. and the mixture was partitioned between ethyl acetate (50 mL) and water (30 mL). The water was separated and extracted with ethyl acetate (50 mL), and the combined EtOAc extracts were washed with brine, dried (MgSO 4 ) and stripped in vacuo. The crude product was chromatographed on silica gel using ethyl acetate/hexanes as eluent (1:9) to give 1-(1-ethylpropyl)-5-methyl-3-thiomethyl-2(1H)-pyrazinone (100 mg). 
     Part D 
     The product from part B (50 mg) and 2,4,6-trimethylaniline (40 mg) were combined in dry THF (2 mL) under inert atmosphere (N 2 ), and cooled to 0° C. To that a 1M solution NaN(SiMe 3 ) 2  in THF (0.5 mL) was added dropwise and the reaction was stirred at 0° C. for 20 min. Then an additional NaN(SiMe 3 ) 2  in THF (0.3 mL) was added and the reaction was stirred at 0° C. for 30 min and at 25° C. for one hour. Then it was quenched with water (30 mL) and extracted with ethyl acetate (80 mL). The ethyl acetate was washed with brine, dried (MgSO 4 ) and stripped in vacuo. The crude product was chromatographed on silica gel using ethyl acetate/hexanes as eluent (1:9) to give 3-[(2,4,6-trimethylphenyl)amino]-1-(1-ethylpropyl)-5-methyl-2(1H)-pyrazinone (40 mg). mp. 109° C. 
     EXAMPLE 84a 
     3-[(2-Chloro-4,6-dimethylphenyl)amino]-1-(1-ethylpropyl)-5-methyl-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 84. Elemental analysis calcd. for C 18 H 24 N 3 OCl: C, 64.76; H, 7.256; N, 12.59. Found: C, 65.12; H, 7.28; N, 12.33. 
     EXAMPLE 84b 
     3-[(2-Chloro-4-methoxy-6-methylphenyl)amino]-1-(1-ethylpropyl)-5-methyl-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 84. Elemental analysis calcd. for C 18 H 24 N 3 O 2 Cl: C, 61.80; H, 6.91; N, 12.01. Found: C, 61.72; H, 6.96; N, 11.83. 
     EXAMPLE 84c 
     3-[(2,4,6-Trimethylphenyl)amino]-1-(1-ethylpropyl)-5-ethyl-2(1H)-pyrazinone 
     Part A 
     5-bromo-1-(1-ethylpropyl)-3-thiomethyl-2(1H)-pyrazinone was prepared in a manner similar to Example 84, parts A and B. 
     Part B 
     To the product of part A (2.14 g) and bis(triphenylphosphine)palladium(II) chloride (258 mg) in anhydrous THF (60 mL) under inert atmosphere was added triethyl aluminum (1 M/THF, 14.7 mL). The reaction was heated at reflux 3 hours and then cooled and quenched with water. Ethyl Acetate (200 mL) was added and washed with water and saturated aqueous sodium chloride. The ethyl acetate was dried over MgSO 4  and concentrated in vacuo. The crude product was chromatographed on silica gel using ethyl acetate/hexane (3:17) as eluent to afford 5-ethyl-1-(1-ethylpropyl)-3-thiomethyl-2(1H)-pyrazinone (809 mg). 
     Part C 
     The title compound was prepared in a manner similar to the product of Example 84 using the product from part B. Elemental analysis calcd. for C 20 H 29 N 3 O: C, 73.36; H, 8.936; N, 12.83. Found: C, 73.01; H, 8.55; N, 12.69. 
     EXAMPLE 84d 
     3-[(2-Chloro-4,6-dimethylphenyl)amino]-1-(1-ethylpropyl)-5-ethyl-2(1H)-pyrazinone 
     The title compound was prepared in a manner similar to the product of Example 84c. Elemental analysis calcd. for C 19 H 26 N 3 OCl: C, 65.60; H, 7.53; N, 12.08. Found: C, 65.53; H, 7.33; N, 11.92. 
     EXAMPLE 85 
     3-[(2,4,6-Trimethylphenyl)amino]-5-bromo-1-(1-ethylpropyl)-2(1H)-pyrazinone 
     Part A 
     N-(1-ethylpropyl)-aminoacetonitrile hydrochloride (1.41 g) and oxalyl bromide (2.0 M, CH 2 Cl2, 13 mL) were heated at reflux for 18 hours. The reaction was concentrated to remove excess oxalyl bromide and solvent, and the crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent to afford 3,5-dibromo-1-(1-ethylpropyl)-2(1H)-pyrazinone as a white solid (1.19 g). 
     Part B 
     Using the product of part A, the title compound was prepared in a manner similar to the product of Example 3. MS m/z 378, (m+H) + , 100%. 
     EXAMPLE 204 
     5-[(2,4,6-Trimethylphenyl)amino]-3-methyl-1-(1-ethylpropyl)-1,2,4-triazine-6(1H)-one 
     Part A 
     3-Pentanone (18.56 g, 0.215 mol), acetic hydrazide (14.8 g, 0.2 mol), and 200 mL of absolute ethanol were placed in a 500 mL flask. The reaction mixture was reluxed for 18 hr and then evaporated to dryness to afford the desired hydrazone of suitable purity. 
     The hydrazone was then dissolved in 200 mL of glacial acetic acid containing 1.0 g of PtO 2  and hydrogenated at 50 psi hydrogen pressure for 14 hr. The mixture was decanted from the catalyst and evaporated to dryness to afford 23.9 g of a colorless oil (83% yield for the two steps). 
     Part B 
     The 1-acetyl-2-(1-ethylpropyl)hydrazine product from Part A (23.9 g, 0.166 mol) was dissolved in CH 2 Cl 2  (200 mL) and to the stirring solution was added triethylamine (27.9 mL, 0.2 mol) and ethyl oxalyl chloride (19 mL, 0.17 mol). After stirring at room temperature for 3 hr, the reaction mixture was poured into water and the organic layer was separated, dried (Na 2 SO 4 ), filtered and evaporated in vacuo. To the resultant oil was added ammonium hydroxide (250 mL), THF (100 mL), and ethanol (50 mL). The flask containing the mixture was sealed with a rubber septum and stirred for 18 hr at room temperature. The mixture was then concentrated in vacuo until the reduced volume of solvent remaining was approximately 100 mL, and a white precipitate had formed. The flask was then placed in the refrigerator for 1 hr. The precipitate was collected by vacuum filtration and washed with small volumes of cold water. 26.3 g of a white solid was collected (73% yield).  1 H NMR (300 MHz, CDCl 3 ): δ 7.78 (s, 1H); 6.74 (br s, 1H); 5.6 (br s, 1H); 4.25 (m, 1H); 2.04 (s, 1H); 1.5 (m, 4H); 0.95 (t, 6H, J=7.3 Hz). 
     Part C 
     The 1-oxamyl-1-(3-pentyl)-2-acetylhydrazine product from Part B (2 g, 9.3 mmol) was suspended in chloroform (50 mL) and 2 mL of iodotrimethylsilane was added dropwise. The mixture was allowed to stir at room temperature for 12 hr. The reaction mixture was then partitioned between CH 2 Cl 2  and 1N NaOH. The aqueous layer was separated and made acidic by addition of conc. HCl and then extracted with CH 2 Cl 2 . This organic layer was dried (Na 2 SO 4 ), filtered and evaporated in vacuo to yield 1.2 g of an off-white solid of suitable purity (65% yield).  1 H NMR (300 MHz, CDCl 3 ): δ 7.85 (br s, 1H); 4.61 (m, 1H); 2.35 (s, 3H); 1.73 (m, 4H); 0.83 (t, 6H, J=7.3 Hz). 
     Part D 
     To a solution of the triazine dione product from above (198 mg, 1 mmol) in CH 2 Cl 2  (5 mL) was added trifluoromethanesulfonic anhydride (0.19 mL, 1.1 mmol) and 2,4,6-collidine (0.15 mL, 1.1 mmol). The resulting reaction mixture was stirred at room temperature for 30 min., then 2,4,6-trimethylaniline (162 mg, 1.2 mmol) in 5 mL of THF was added followed by addition of 2,4,6-collidine (0.15 mL, 1.1 mmol). The resulting reaction mixture was stirred at room temperature for 1 hr, at which time TLC showed complete reaction. The reaction mixture was partitioned between water and CH 2 Cl 2 . The organic layer was dried (Na 2 SO 4 ), filtered and evaporated in vacuo. The residue was purified by column chromatography on silica gel using EtOAc/hexane (1:9) to afford 260 mg of the title compound (83% yield). mp=133-135° C.  1 H NMR (300 MHz, CDCl 3 ): δ 7.89 (br s, 1H); 6.94 (s, 2H); 4.72 (m, 1H); 2.31 (s, 3H); 2.19 (s, 9H); 1.9-1.7 (m, 4H); 0.85 (t, 6H, J=7.32 Hz). Mass Spec. (NH 3 -CI): Calc. (M+H)+=315, Obs. (M+H)+=315. 
     EXAMPLE 703 
     (+/−)-5-Chloro-1-[1-(methoxymethyl)propyl]-3-(2,4,6-trimethylphenoxy)-2(1H)-pyrazinone 
     Part A 
     (+/−)-3,5-dichloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone was prepared in a manner similar to Example 12, part A, and Example 1, part B. 
     Part B 
     2,4,6-Trimethylphenol (59 mg) and potassium t-butoxide (48 mg) were added to pyridine (2 mL) at 0° C. The mixture was warmed to ambient temperature and (+/−)-3,5-dichloro-1-[1-(methoxymethyl)propyl]-2(1H)-pyrazinone (98 mg) and copper (I) iodide (19 mg) were added. The reaction mixture was stirred at ambient temperature for three hours and then heated at reflux for three hours and then cooled to 0° C. Ethyl acetate (50 mL) and saturated ammonium chloride (50 mL) were added and the mixture was stirred overnight at ambient temperature. The layers were separated, and the organic layer was washed with 1M ammonium hydroxide (2×50 mL), 1N sodium hydroxide (2×50 mL), 1N hydrochloric acid (2×50 mL), and saturated sodium chloride (50 mL). The ethyl acetate was dried over MgSO 4  and concentrated in vacuo. The crude product was chromatographed on silica gel using ethyl acetate/hexane (1:4) as eluent to afford the title compound (66 mg). mp=116° C. Elemental analysis calcd. for C 18 H 23 N 2 O 3 Cl: C, 61.62; H, 6.618; N, 7.98. Found: C, 61.45; H, 6.44; N, 7.77. 
     Various analogs synthesized using Schemes 1, 2 and 3 listed in Table 1. 
     
       
         
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 Ex 
                   
                   
                   
                   
                   
               
               
                 No 
                 R 1   
                 R 3   
                 Y 
                 Ar 
                 mp/° C. 
               
               
                   
               
               
                 1 
                 Cl 
                 Et 2 CH 
                 NH 
                 2-Br-4-iPr-phenyl 
                 118.5 
               
               
                 2 
                 Cl 
                 Et 2 CH 
                 NEt 
                 2-Br-4-iPr-phenyl 
                 MS = 440 
               
               
                 3 
                 Cl 
                 Et 2 CH 
                 NH 
                 2,4-Br 2 -phenyl 
                 155.5 
               
               
                 4 
                 Cl 
                 Et 2 CH 
                 NEt 
                 2,4-Br 2 -phenyl 
                  88.1 
               
               
                 5 
                 Cl 
                 Et 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
                 180.8 
               
               
                 6 
                 Cl 
                 Et 2 CH 
                 NEt 
                 2,4,6-Me 3 -phenyl 
                  93.8 
               
               
                 7 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
                 153.8 
               
               
                 8 
                 Cl 
                 Et 2 CH 
                 NH 
                 2-Br-4,6-(MeO) 2 - 
                 181.3 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 9 
                 Cl 
                 Et 2 CH 
                 NH 
                 2-CN-4,6-Me 2 -phenyl 
                 174.0 
               
               
                 10 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Br-4,6-(MeO) 2 - 
                 175.8 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 11 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-4,6-(MeO) 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 12 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-I-4,6-Me 2 -phenyl 
                 109.4 
               
               
                 13 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-CN-4,6-Me 2 -phenyl 
               
               
                 14 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Br-4,6-Me 2 -phenyl 
               
               
                 15 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
                 152.8 
               
               
                 16 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 4-MeCO-2,6-Me 2 -phenyl 
                 127.1 
               
               
                 16a 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 4-MeCO-2-OMe-6-Me- 
                 179.8 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 17 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-MeCO-4,6-Me 2 -phenyl 
               
               
                 18 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 4,6-Me 2 -2-SMe-phenyl 
               
               
                 19 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 4,6-Me 2 -2-SO 2 Me-phenyl 
               
               
                 20 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 4-Cl-2-I-6-Me-phenyl 
                 121.8 
               
               
                 21 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
                 127.2 
               
               
                 22 
                 Cl 
                 phenyl 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 23 
                 CN 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 24 
                 CONH 2   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 25 
                 COOH 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 26 
                 CHO 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 27 
                 CH 2 OH 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 28 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4-Br 2 -phenyl 
               
               
                 29 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Br-4-iPr-phenyl 
               
               
                 30 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 30a 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-4,6-Me 3 -phenyl 
                 117.9 
               
               
                 31 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 32 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 33 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 34 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4-Br 2 -6-Me-phenyl 
               
               
                 35 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 36 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
                 120.0 
               
               
                 36a 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 4-Br-2-OMe-6-Me- 
                 130.9 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 37 
                 Cl 
                 (MeOC 2 H 4 ) 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 38 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 39 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 40 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 41 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 42 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 43 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4-Me 2 -6-MeOCH 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 44 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 45 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 45a 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Br-6-F-4-Me-phenyl 
                 138.9 
               
               
                 46 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 46a 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Cl-4-OMe-6-Me- 
                 128.3 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 47 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4-Me 2 -6-MeOCH 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 48 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 49 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
                 138.6 
               
               
                 50 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 51 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4-Me 2 -6-MeOCH 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 52 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 53 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
                 152.1 
               
               
                 54 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
                 132.8 
               
               
                 55 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4-Me 2 -6-MeOCH 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 56 
                 Cl 
                 MeOCH 2 (Me)CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 57 
                 Cl 
                 MeOCH 2 (Me)CH 
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 58 
                 Cl 
                 EtOCH 2 (Et)CH 
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 59 
                 Cl 
                 EtOCH 2 (Me)CH 
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 60 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 4-Br-2,6-F 2 -phenyl 
               
               
                 61 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2-Br-4,6-Me 2 -phenyl 
               
               
                 62 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4-Me 2 -6-SMe-phenyl 
               
               
                 63 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4-Me 2 -6-SO 2 Me- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 64 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 4-NMe 2 -2,6-Me 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 65 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 66 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 4-Cl-2,6-Me 2 -phenyl 
               
               
                 67 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,6-Me 2 -4-SMe-phenyl 
               
               
                 68 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,6-Me 2 -4-OMe-phenyl 
               
               
                 69 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,6-Me 2 -4-SO 2 Me-phenyl 
               
               
                 70 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 4-MeC(O)-2,6-Me 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 71 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 72 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 4-MeC(O)-2,6-Me 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 73 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,6-Me 2 -4-SMe-phenyl 
               
               
                 74 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,6-Me 2 -4-SO 2 Me-phenyl 
               
               
                 75 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 4-NMe 2 -2,6-Me 2 -phenyl 
               
               
                 76 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-NMe 2 -4,6-Me 2 -phenyl 
               
               
                 77 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,6-Me 2 -4-SMe-phenyl 
                 104.9 
               
               
                 78 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,6-Me 2 -4-SO 2 Me-phenyl 
               
               
                 79 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
                 116.7 
               
               
                 80 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 4-Br-6-OMe-2-Me-phenyl 
                 147.8 
               
               
                 81 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,6-Me 2 -4-SMe-phenyl 
                 158.9 
               
               
                 82 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,6-Me 2 -4-SO 2 Me-phenyl 
               
               
                 83 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 4-Br-6-OMe-2-Me-phenyl 
                 175.5 
               
               
                 84 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
                 109   
               
               
                 84a 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
                 133.8 
               
               
                 84b 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-4-OMe-6-Me- 
                 121.9 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 84c 
                 CH 2 CH 3   
                 Et 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
                  79.3 
               
               
                 84d 
                 CH 2 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
                  95.6 
               
               
                 85 
                 Br 
                 Et 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
                 MS = 378 
               
               
                 86 
                 Br 
                 Et 2 CH 
                 NH 
                 2-Br-4-iPr-phenyl 
               
               
                 87 
                 Br 
                 Et 2 CH 
                 NEt 
                 2-Br-4-iPr-phenyl 
               
               
                 88 
                 Br 
                 Et 2 CH 
                 NH 
                 2,4-Br 2 -phenyl 
               
               
                 89 
                 Br 
                 Et 2 CH 
                 NEt 
                 2,4-Br 2 -phenyl 
               
               
                 90 
                 Br 
                 Et 2 CH 
                 NEt 
                 2,4,6-Me 3 -phenyl 
               
               
                 91 
                 Br 
                 Et 2 CH 
                 NEt 
                 2,4,6-Me 3 -phenyl 
               
               
                 92 
                 Br 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 93 
                 Br 
                 Et 2 CH 
                 NH 
                 2-Br-4,6-(MeO) 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 94 
                 Br 
                 Et 2 CH 
                 NH 
                 2-CN-4,6-Me 2 -phenyl 
               
               
                 95 
                 Br 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Br-4,6-(MeO) 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 96 
                 Br 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-I-4,6-Me 2 -phenyl 
               
               
                 97 
                 Br 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,6-Me 2 -4-Br-phenyl 
               
               
                 98 
                 Br 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-I-4-Cl-6-Me-phenyl 
               
               
                 99 
                 Br 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 100 
                 Br 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,6-Me 2 -4-SMe-phenyl 
               
               
                 101 
                 Br 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,6-Me 2 -4-SO 2 Me- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 102 
                 Br 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 103 
                 Br 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Me-4-Br-6-OMe- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 104 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 105 
                 CH 3   
                 Et 2 CH 
                 NH 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 106 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 107 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 108 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 109 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 110 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 111 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 112 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 113 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 114 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 115 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 116 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 117 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 118 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 119 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 120 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 121 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 120 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 123 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 124 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 125 
                 Cl 
                 Et 2 CH 
                 NH 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 124 
                 Cl 
                 Et 2 CH 
                 NH 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 127 
                 Cl 
                 Et 2 CH 
                 NH 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 128 
                 Cl 
                 Et 2 CH 
                 NH 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 129 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 130 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 131 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 132 
                 Cl 
                 Et 2 CH 
                 NH 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 133 
                 Cl 
                 Et 2 CH 
                 NH 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 134 
                 Cl 
                 Et 2 CH 
                 NH 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 135 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 136 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 137 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 138 
                 Cl 
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 139 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 140 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 141 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 142 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 143 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 144 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 145 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 146 
                 Et 2 CH 
                 CH 3   
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 147 
                 Et 2 CH 
                 CH 3   
                 NH 
                 2,6-Me 2 -4-Br-phenyl 
               
               
                 148 
                 Et 2 CH 
                 CH 3   
                 NH 
                 2-Br-4-iPr-phenyl 
               
               
                 149 
                 MeOCH 2 (Et)CH 
                 CH 3   
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 150 
                 MeOCH 2 (Et)CH 
                 CH 3   
                 NH 
                 2,6-Me 2 -4-Br-phenyl 
               
               
                 151 
                 MeOCH 2 (Et)CH 
                 CH 3   
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 152 
                 (MeOCH 2 ) 2 CH 
                 CH 3   
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 153 
                 (MeOCH 2 ) 2 CH 
                 CH 3   
                 NH 
                 2,6-Me 2 -4-Br-phenyl 
               
               
                 154 
                 (MeOCH 2 ) 2 CH 
                 CH 3   
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 155 
                 Et 2 CH 
                 CH 3   
                 NH 
                 2-Br-4,6-(MeO) 2 -phenyl 
               
               
                 156 
                 Et 2 CH 
                 CH 3   
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 400 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 401 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 402 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 403 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2,4,6-Cl 3 -phenyl 
               
               
                 404 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2-Me-4-MeO-phenyl 
               
               
                 405 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2-Cl-4-MeO-phenyl 
               
               
                 406 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 407 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 408 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 409 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 410 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2,4-Cl 2 -phenyl 
               
               
                 411 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2-Cl-4-Me-phenyl 
               
               
                 412 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2-Me-4-Cl-phenyl 
               
               
                 413 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 414 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 415 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 416 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 417 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 418 
                 CH 3   
                 Me(Et)CH 
                 NH 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 419 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 420 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 421 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 422 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2,4,6-Cl 3 -phenyl 
               
               
                 423 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2-Me-4-MeO-phenyl 
               
               
                 424 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2-Cl-4-MeO-phenyl 
               
               
                 425 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 426 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 427 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 428 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 429 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2,4-Cl 2 -phenyl 
               
               
                 430 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2-Cl-4-Me-phenyl 
               
               
                 431 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2-Me-4-Cl-phenyl 
               
               
                 432 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 433 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 434 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 435 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 436 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 437 
                 CH 3   
                 Me(n-Pr)CH 
                 NH 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 438 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 439 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4,6-Cl 3 -phenyl 
               
               
                 440 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Me-4-MeO-phenyl 
               
               
                 441 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-4-MeO-phenyl 
               
               
                 442 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 443 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 444 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 445 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 446 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4-Cl 2 -phenyl 
               
               
                 447 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-4-Me-phenyl 
               
               
                 448 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Me-4-Cl-phenyl 
               
               
                 449 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 450 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 451 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 452 
                 CH 3   
                 Et 2 CH 
                 NH 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 453 
                 CH 3   
                 Et 2 CH 
                 NH 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 454 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 455 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 456 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 457 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2,4,6-Cl 3 -phenyl 
               
               
                 458 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2-Me-4-MeO-phenyl 
               
               
                 459 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2-Cl-4-MeO-phenyl 
               
               
                 460 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 461 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 462 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 463 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 464 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2,4-Cl 2 -phenyl 
               
               
                 465 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2-Cl-4-Me-phenyl 
               
               
                 466 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2-Me-4-Cl-phenyl 
               
               
                 467 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 468 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 469 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 470 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 471 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 472 
                 CH 3   
                 (c-Pr) 2 CH 
                 NH 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 473 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 474 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 475 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 476 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2,4,6-Cl 3 -phenyl 
               
               
                 477 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2-Me-4-MeO-phenyl 
               
               
                 478 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2-Cl-4-MeO-phenyl 
               
               
                 479 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 480 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 481 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 482 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 483 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2,4-Cl 2 -phenyl 
               
               
                 484 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2-Cl-4-Me-phenyl 
               
               
                 485 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2-Me-4-Cl-phenyl 
               
               
                 486 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 487 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 488 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 489 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 490 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 491 
                 CH 3   
                 c-Pr(Me)CH 
                 NH 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 492 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 493 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 494 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 495 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2,4,6-Cl 3 -phenyl 
               
               
                 496 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2-Me-4-MeO-phenyl 
               
               
                 497 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2-Cl-4-MeO-phenyl 
               
               
                 498 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 499 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 500 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 501 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 502 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2,4-Cl 2 -phenyl 
               
               
                 503 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2-Cl-4-Me-phenyl 
               
               
                 504 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2-Me-4-Cl-phenyl 
               
               
                 505 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 506 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 507 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 508 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 509 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 510 
                 CH 3   
                 c-Pr(Et)CH 
                 NH 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 511 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 512 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 513 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 514 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2,4,6-Cl 3 -phenyl 
               
               
                 515 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2-Me-4-MeO-phenyl 
               
               
                 516 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2-Cl-4-MeO-phenyl 
               
               
                 517 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 518 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 519 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 520 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 521 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2,4-Cl 2 -phenyl 
               
               
                 522 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2-Cl-4-Me-phenyl 
               
               
                 523 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2-Me-4-Cl-phenyl 
               
               
                 524 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 525 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 526 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 527 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 528 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 529 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 NH 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 530 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 531 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 532 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 533 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2,4,6-Cl 3 -phenyl 
               
               
                 534 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2-Me-4-MeO-phenyl 
               
               
                 535 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2-Cl-4-MeO-phenyl 
               
               
                 536 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 537 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 538 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 539 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 540 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2,4-Cl 2 -phenyl 
               
               
                 541 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2-Cl-4-Me-phenyl 
               
               
                 542 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2-Me-4-Cl-phenyl 
               
               
                 543 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 544 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 545 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 546 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 547 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 548 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 NH 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 549 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 550 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 551 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 552 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2,4,6-Cl 3 -phenyl 
               
               
                 553 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2-Me-4-MeO-phenyl 
               
               
                 554 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2-Cl-4-MeO-phenyl 
               
               
                 555 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 556 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 557 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 558 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 559 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2,4-Cl 2 -phenyl 
               
               
                 560 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2-Cl-4-Me-phenyl 
               
               
                 561 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2-Me-4-Cl-phenyl 
               
               
                 562 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 563 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 564 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 565 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 566 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 567 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 NH 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                   
               
             
          
         
       
     
     Compounds that can be synthesized using synthetic Scheme 6 or Scheme 7 are listed in Table 2. 
     
       
         
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 Ex. 
                   
                   
                   
                   
                   
               
               
                 No. 
                 R 1   
                 R 3   
                 Y 
                 Ar 
                 mp 
               
               
                   
               
               
                 200 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4-Br 2 -phenyl 
                   
               
               
                 201 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Br-4-iPr-phenyl 
               
               
                 202 
                 CH 3   
                 Et 2 CH 
                 NEt 
                 2,4-Br 2 -phenyl 
               
               
                 203 
                 CH 3   
                 Et 2 CH 
                 NEt 
                 2-Br-4-iPr-phenyl 
               
               
                 204 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
                 133 
               
               
                 205 
                 CH 3   
                 Et 2 CH 
                 NEt 
                 2,4,6-Me 3 -phenyl 
               
               
                 206 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 207 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Br-4,6-(MeO) 2 -phenyl 
               
               
                 208 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Br-4,6-(MeO) 2 -phenyl 
               
               
                 209 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-4,6-(MeO) 2 -phenyl 
               
               
                 210 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4-Me 2 -6-I-phenyl 
               
               
                 211 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-CN-4,6-Me 2 -phenyl 
               
               
                 212 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Br-4,6-Me 2 -phenyl 
               
               
                 213 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 214 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 4-MeC(O)-2,6-Me 2 -phenyl 
               
               
                 215 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-MeC(O)-4,6-Me 2 -phenyl 
               
               
                 216 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4-Me 2 -6-SMe-phenyl 
               
               
                 217 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4-Me 2 -6-SO 2 Me-phenyl 
               
               
                 218 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 4-Cl-2-I-6-Me-phenyl 
               
               
                 219 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 220 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 221 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 222 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4-Br 2 -6-Me-phenyl 
               
               
                 223 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 224 
                 CH 3   
                 (MeOC 2 H 4 ) 2 CH 
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 225 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 226 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 227 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2-Br-4,6-Me 2 -phenyl 
               
               
                 228 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 229 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 NH 
                 2,4-Me 2 -6-MeOCH 2 -phenyl 
               
               
                 230 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 231 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 232 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 233 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 NH 
                 2,4-Me 2 -6-MeOCH 2 -phenyl 
               
               
                 234 
                 CH 3   
                 MeOCH 2 (Me)CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 235 
                 CH 3   
                 MeOCH 2 (Me)CH 
                 NH 
                 2-Br-4,6-Me 2 -phenyl 
               
               
                 236 
                 CH 3   
                 EtOCH 2 (Et)CH 
                 NH 
                 2-Br-4,6-Me 2 -phenyl 
               
               
                 237 
                 CH 3   
                 EtOCH 2 (Me)CH 
                 NH 
                 2-Br-4,6-Me 2 -phenyl 
               
               
                 238 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Br-4,6-F 2 -phenyl 
               
               
                 239 
                 Et 2 CH 
                 CH 3   
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 240 
                 Et 2 CH 
                 CH 3   
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 241 
                 Et 2 CH 
                 CH 3   
                 NH 
                 2-Br-4-iPr-phenyl 
               
               
                 242 
                 MeOCH 2 (Et)CH 
                 CH 3   
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 243 
                 MeOCH 2 (Et)CH 
                 CH 3   
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 244 
                 MeOCH 2 (Et)CH 
                 CH 3   
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 245 
                 (MeOCH 2 ) 2 CH 
                 CH 3   
                 NH 
                 2,4,6-Me 3 -phenyl 
               
               
                 246 
                 (MeOCH 2 ) 2 CH 
                 CH 3   
                 NH 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 247 
                 (MeOCH 2 ) 2 CH 
                 CH 3   
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 248 
                 Et 2 CH 
                 CH 3   
                 NH 
                 2-Br-4,6-(MeO) 2 -phenyl 
               
               
                 249 
                 Et 2 CH 
                 CH 3   
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 250 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 251 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 252 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4,6-Cl 3 -phenyl 
               
               
                 253 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Me-4-MeO-phenyl 
               
               
                 254 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-4-MeO-phenyl 
               
               
                 255 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 256 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 257 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 258 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 259 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2,4-Cl 2 -phenyl 
               
               
                 260 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-4-Me-phenyl 
               
               
                 261 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Me-4-Cl-phenyl 
               
               
                 262 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 263 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 264 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 265 
                 CH 3   
                 Et 2 CH 
                 NH 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 266 
                 CH 3   
                 Et 2 CH 
                 NH 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 267 
                 CH 3   
                 Et 2 CH 
                 NH 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 268 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 269 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 270 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Cl 3 -phenyl 
               
               
                 271 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Me-4-MeO-phenyl 
               
               
                 272 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-4-MeO-phenyl 
               
               
                 273 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 274 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 275 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 276 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2,4-Cl 2 -phenyl 
               
               
                 277 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-4-Me-phenyl 
               
               
                 278 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Me-4-Cl-phenyl 
               
               
                 279 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 280 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 281 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 282 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 283 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 284 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 NH 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                   
               
             
          
         
       
     
     Compounds wherein Y=Oxygen that can be synthesized synthetic Scheme 3 are listed in Table 3. 
     
       
         
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 3 
               
             
             
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 Ex 
                   
                   
                   
                   
                   
               
               
                 No 
                 R 1   
                 R 3   
                 Y 
                 Ar 
                 mp/° C. 
               
               
                   
               
               
                 700 
                 Cl 
                 Et 2 CH 
                 O 
                 2-Br-4-iPr-phenyl 
                   
               
               
                 701 
                 Cl 
                 Et 2 CH 
                 O 
                 2,4-Br 2 -phenyl 
               
               
                 702 
                 Cl 
                 Et 2 CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 703 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2,4,6-Me 3 -phenyl 
                 116 
               
               
                 704 
                 Cl 
                 Et 2 CH 
                 O 
                 2-Br-4,6-(MeO) 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 705 
                 Cl 
                 Et 2 CH 
                 O 
                 2-CN-4,6-Me 2 -phenyl 
               
               
                 706 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2-Br-4,6-(MeO) 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 707 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2-Cl-4,6-(MeO) 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 708 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2-I-4,6-Me 2 -phenyl 
               
               
                 709 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2-CN-4,6-Me 2 -phenyl 
               
               
                 710 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2-Br-4,6-Me 2 -phenyl 
               
               
                 711 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 712 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 4-MeCO-2,6-Me 2 -phenyl 
               
               
                 713 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 4-MeCO-2-OMe-6-Me- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 714 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2-MeCO-4,6-Me 2 -phenyl 
               
               
                 715 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 4,6-Me 2 -2-SMe-phenyl 
               
               
                 716 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 4,6-Me 2 -2-SO 2 Me-phenyl 
               
               
                 717 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 4-Cl-2-I-6-Me-phenyl 
               
               
                 718 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 719 
                 Cl 
                 phenyl 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 720 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 O 
                 2,4-Br 2 -phenyl 
               
               
                 721 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 O 
                 2-Br-4-iPr-phenyl 
               
               
                 722 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 723 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 724 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 725 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 726 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 727 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,4-Br 2 -6-Me-phenyl 
               
               
                 728 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 729 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 730 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 4-Br-2-OMe-6-Me- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 731 
                 Cl 
                 (MeOC 2 H 4 ) 2 CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 732 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 733 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 734 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 735 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 736 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 737 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,4-Me 2 -6-MeOCH 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 738 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 739 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 740 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Br-6-F-4-Me-phenyl 
               
               
                 741 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 742 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Cl-4-OMe-6-Me- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 743 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,4-Me 2 -6-MeOCH 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 744 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 745 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 746 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 747 
                 Cl 
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,4-Me 2 -6-MeOCH 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 748 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 749 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 750 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 751 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,4-Me 2 -6-MeOCH 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 752 
                 Cl 
                 MeOCH 2 (Me)CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 753 
                 Cl 
                 MeOCH 2 (Me)CH 
                 O 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 754 
                 Cl 
                 EtOCH 2 (Et)CH 
                 O 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 755 
                 Cl 
                 EtOCH 2 (Me)CH 
                 O 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 756 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 4-Br-2,6-F 2 -phenyl 
               
               
                 757 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2-Br-4,6-Me 2 -phenyl 
               
               
                 758 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,4-Me 2 -6-SMe-phenyl 
               
               
                 759 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,4-Me 2 -6-SO 2 Me- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 760 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 4-NMe 2 -2,6-Me 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 761 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 762 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 4-Cl-2,6-Me 2 -phenyl 
               
               
                 763 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,6-Me 2 -4-SMe-phenyl 
               
               
                 764 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,6-Me 2 -4-OMe-phenyl 
               
               
                 765 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 2,6-Me 2 -4-SO 2 Me-phenyl 
               
               
                 766 
                 CH 3   
                 MeOC 2 H 4 (MeOCH 2 )CH 
                 O 
                 4-MeC(O)-2,6-Me 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 767 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 4-Br-2,6-Me 2 -phenyl 
               
               
                 768 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 4-MeC(O)-2,6-Me 2 - 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 769 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,6-Me 2 -4-SMe-phenyl 
               
               
                 770 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,6-Me 2 -4-SO 2 Me-phenyl 
               
               
                 771 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 4-NMe 2 -2,6-Me 2 -phenyl 
               
               
                 772 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-NMe 2 -4,6-Me 2 -phenyl 
               
               
                 773 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2,6-Me 2 -4-SMe-phenyl 
               
               
                 774 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2,6-Me 2 -4-SO 2 Me-phenyl 
               
               
                 775 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 776 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 4-Br-6-OMe-2-Me-phenyl 
               
               
                 777 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,6-Me 2 -4-SMe-phenyl 
               
               
                 778 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,6-Me 2 -4-SO 2 Me-phenyl 
               
               
                 779 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 4-Br-6-OMe-2-Me-phenyl 
               
               
                 780 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 781 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 782 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-4-OMe-6-Me- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 783 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 784 
                 CH 3   
                 Et 2 CH 
                 O 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 785 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 786 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 787 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 788 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 789 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 790 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 O 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 791 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 O 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 792 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 O 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 793 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 794 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 795 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 796 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 797 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 O 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 798 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 O 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 799 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 O 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 800 
                 CH 3   
                 MeOCH 2 (Et)CH 
                 O 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 801 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 802 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 803 
                 CH 3   
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 804 
                 Cl 
                 Et 2 CH 
                 O 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 805 
                 Cl 
                 Et 2 CH 
                 O 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 806 
                 Cl 
                 Et 2 CH 
                 O 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 807 
                 Cl 
                 Et 2 CH 
                 O 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 808 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 809 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 810 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 811 
                 Cl 
                 Et 2 CH 
                 O 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 812 
                 Cl 
                 Et 2 CH 
                 O 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 813 
                 Cl 
                 Et 2 CH 
                 O 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 814 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 815 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 816 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 817 
                 Cl 
                 MeOCH 2 (Et)CH 
                 O 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 818 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Br-6-OMe-pyrid-3-yl 
               
               
                 819 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,6-Me 2 -pyrid-3-yl 
               
               
                 820 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Cl-6-Me-pyrid-3-yl 
               
               
                 821 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Cl-6-OMe-pyrid-3-yl 
               
               
                 822 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2,4,6-Me 3 -pyrid-3-yl 
               
               
                 823 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 4,6-Me 2 -pyrid-3-yl 
               
               
                 824 
                 Cl 
                 (MeOCH 2 ) 2 CH 
                 O 
                 2-Br-6-Me-pyrid-3-yl 
               
               
                 825 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 826 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 827 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 828 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2,4,6-Cl 3 -phenyl 
               
               
                 829 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2-Me-4-MeO-phenyl 
               
               
                 830 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2-Cl-4-MeO-phenyl 
               
               
                 831 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 832 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 833 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 834 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 835 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2,4-Cl 2 -phenyl 
               
               
                 836 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2-Cl-4-Me-phenyl 
               
               
                 837 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2-Me-4-Cl-phenyl 
               
               
                 838 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 839 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 840 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 841 
                 CH 3   
                 Me(Et)CH 
                 O 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 842 
                 CH 3   
                 Me(Et)CH 
                 O 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 843 
                 CH 3   
                 Me(Et)CH 
                 O 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 844 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 845 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 846 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 847 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2,4,6-Cl 3 -phenyl 
               
               
                 848 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2-Me-4-MeO-phenyl 
               
               
                 849 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2-Cl-4-MeO-phenyl 
               
               
                 850 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 851 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 852 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 853 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 854 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2,4-Cl 2 -phenyl 
               
               
                 855 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2-Cl-4-Me-phenyl 
               
               
                 856 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2-Me-4-Cl-phenyl 
               
               
                 857 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 858 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 859 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 860 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 861 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 862 
                 CH 3   
                 Me(n-Pr)CH 
                 O 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 863 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 864 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 865 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 866 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2,4,6-Cl 3 -phenyl 
               
               
                 867 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2-Me-4-MeO-phenyl 
               
               
                 868 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2-Cl-4-MeO-phenyl 
               
               
                 869 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 870 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 871 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 872 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 873 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2,4-Cl 2 -phenyl 
               
               
                 874 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2-Cl-4-Me-phenyl 
               
               
                 875 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2-Me-4-Cl-phenyl 
               
               
                 876 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 877 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 878 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 879 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 880 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 881 
                 CH 3   
                 c-Pr 2 CH 
                 O 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 882 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 883 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 884 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 885 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2,4,6-Cl 3 -phenyl 
               
               
                 886 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2-Me-4-MeO-phenyl 
               
               
                 887 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2-Cl-4-MeO-phenyl 
               
               
                 888 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 889 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 890 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 891 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 892 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2,4-Cl 2 -phenyl 
               
               
                 893 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2-Cl-4-Me-phenyl 
               
               
                 894 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2-Me-4-Cl-phenyl 
               
               
                 895 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 896 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 897 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 898 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 899 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 900 
                 CH 3   
                 c-Pr(Me)CH 
                 O 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 901 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 902 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 903 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 904 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2,4,6-Cl 3 -phenyl 
               
               
                 905 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2-Me-4-MeO-phenyl 
               
               
                 906 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2-Cl-4-MeO-phenyl 
               
               
                 907 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 908 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 909 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 910 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 911 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2,4-Cl 2 -phenyl 
               
               
                 912 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2-Cl-4-Me-phenyl 
               
               
                 913 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2-Me-4-Cl-phenyl 
               
               
                 914 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 915 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 916 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 917 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 918 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 919 
                 CH 3   
                 c-Pr(Et)CH 
                 O 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 920 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 921 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 922 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 923 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2,4,6-Cl 3 -phenyl 
               
               
                 924 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2-Me-4-MeO-phenyl 
               
               
                 925 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2-Cl-4-MeO-phenyl 
               
               
                 926 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 927 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 928 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 929 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 930 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2,4-Cl 2 -phenyl 
               
               
                 931 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2-Cl-4-Me-phenyl 
               
               
                 932 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2-Me-4-Cl-phenyl 
               
               
                 933 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 934 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 935 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 936 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 937 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 938 
                 CH 3   
                 c-Pr(n-Pr)CH 
                 O 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 939 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 940 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 941 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 942 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2,4,6-Cl 3 -phenyl 
               
               
                 943 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2-Me-4-MeO-phenyl 
               
               
                 944 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2-Cl-4-MeO-phenyl 
               
               
                 945 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 946 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 947 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 948 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 949 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2,4-Cl 2 -phenyl 
               
               
                 950 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2-Cl-4-Me-phenyl 
               
               
                 951 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2-Me-4-Cl-phenyl 
               
               
                 952 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 953 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 954 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 955 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 956 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 957 
                 CH 3   
                 c-Pr(n-Bu)CH 
                 O 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 958 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2,4,6-Me 3 -phenyl 
               
               
                 959 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 960 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 961 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2,4,6-Cl 3 -phenyl 
               
               
                 962 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2-Me-4-MeO-phenyl 
               
               
                 963 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2-Cl-4-MeO-phenyl 
               
               
                 964 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 965 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 966 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 967 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 968 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2,4-Cl 2 -phenyl 
               
               
                 969 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2-Cl-4-Me-phenyl 
               
               
                 970 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2-Me-4-Cl-phenyl 
               
               
                 971 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 972 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 973 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 974 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 975 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 976 
                 CH 3   
                 c-PrCH 2 (Et)CH 
                 O 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 977 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 978 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4,6-Cl 3 -phenyl 
               
               
                 979 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Me-4-MeO-phenyl 
               
               
                 980 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-4-MeO-phenyl 
               
               
                 981 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 982 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 983 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 984 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 985 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4-Cl 2 -phenyl 
               
               
                 986 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-4-Me-phenyl 
               
               
                 987 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Me-4-Cl-phenyl 
               
               
                 988 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 989 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 990 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 991 
                 CH 3   
                 Et 2 CH 
                 O 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 992 
                 CH 3   
                 Et 2 CH 
                 O 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                   
               
             
          
         
       
     
     Additional compounds, wherein Y=oxygen that can be synthesized using synthetic Scheme 6 or Scheme 7 are listed in Table 4. 
     
       
         
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 4 
               
             
             
               
                   
               
               
                 
                   
                             
                     
                         
                         
                     
                   
                 
               
               
                   
               
             
          
           
               
                 Ex. 
                   
                   
                   
                   
                   
               
               
                 No. 
                 R 1   
                 R 3   
                 Y 
                 Ar 
                 mp 
               
               
                   
               
               
                 1000 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4,6-Me 3 -phenyl 
                   
               
               
                 1001 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-4,6-Me 2 -phenyl 
               
               
                 1002 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4-Cl 2 -6-Me-phenyl 
               
               
                 1003 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4,6-Cl 3 -phenyl 
               
               
                 1004 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Me-4-MeO-phenyl 
               
               
                 1005 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-4-MeO-phenyl 
               
               
                 1006 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4,6-Me 3 -5-F-phenyl 
               
               
                 1007 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,5-Me 2 -4-MeO-phenyl 
               
               
                 1008 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4-Me 2 -6-MeO-phenyl 
               
               
                 1009 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,6-Cl 2 -4-Me-phenyl 
               
               
                 1010 
                 CH 3   
                 Et 2 CH 
                 O 
                 2,4-Cl 2 -phenyl 
               
               
                 1011 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-4-Me-phenyl 
               
               
                 1012 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Me-4-Cl-phenyl 
               
               
                 1013 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-NMe 2 -6-Me-pyrid-5-yl 
               
               
                 1014 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-NMe 2 -4-Me-pyrid-5-yl 
               
               
                 1015 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-4-MeO-6-Me-phenyl 
               
               
                 1016 
                 CH 3   
                 Et 2 CH 
                 O 
                 2-Cl-4,6-Me 2 -5-F- 
               
               
                   
                   
                   
                   
                 phenyl 
               
               
                 1017 
                 CH 3   
                 Et 2 CH 
                 O 
                 6-Cl-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                 1018 
                 CH 3   
                 Et 2 CH 
                 O 
                 6-Me-2,3-dihydro- 
               
               
                   
                   
                   
                   
                 benzofuran-5-yl 
               
               
                   
               
             
          
         
       
     
     UTILITY 
     CRF-R1 Receptor Binding Assay for the Evaluation of Biological Activity 
     The following is a description of the isolation of cell membranes containing cloned human CRF-R1 receptors for use in the standard binding assay as well as a description of the assay itself. 
     Messenger RNA was isolated from human hippocampus. The mRNA was reverse transcribed using oligo (dt) 12-18 and the coding region was amplified by PCR from start to stop codons. The resulting PCR fragment was cloned into the EcoRV site of pGEMV, from whence the insert was reclaimed using XhoI+XbaI and cloned into the XhoI+XbaI sites of vector pm3ar (which contains a CMV promoter, the SV40 ‘t’ splice and early poly A signals, an Epstein-Barr viral origin of replication, and a hygromycin selectable marker). The resulting expression vector, called phchCRFR was transfected in 293EBNA cells and cells retaining the episome were selected in the presence of 400 mM hygromycin. Cells surviving 4 weeks of selection in hygromycin were pooled, adapted to growth in suspension and used to generate membranes for the binding assay described below. Individual aliquots containing approximately 1×10 8  of the suspended cells were then centrifuged to form a pellet and frozen. 
     For the binding assay a frozen pellet described above containing 293EBNA cells transfected with hCRFR1 receptors is homogenized in 10 ml of ice cold tissue buffer (50 mM HEPES buffer pH 7.0, containing 10 mM MgCl 2 , 2 mM EGTA, 1 mg/l aprotinin, 1 mg/ml leupeptin and 1 mg/ml pepstatin). The homogenate is centrifuged at 40,000×g for 12 min and the resulting pellet rehomogenized in 10 ml of tissue buffer. After another centrifugation at 40,000×g for 12 min, the pellet is resuspended to a protein concentration of 360 mg/ml to be used in the assay. 
     Binding assays are performed in 96 well plates; each well having a 300 ml capacity. To each well is added 50 ml of test drug dilutions (final concentration of drugs range from 10− 10 -10− 5  M), 100 ml of  125 I-ovine-CRF ( 125 I-o-CRF) (final concentration 150 pM) and 150 ml of the cell homogenate described above. Plates are then allowed to incubate at room temperature for 2 hours before filtering the incubate over GF/F filters (presoaked with 0.3% polyethyleneimine) using an appropriate cell harvester. Filters are rinsed 2 times with ice cold assay buffer before removing individual filters and assessing them for radioactivity on a gamma counter. 
     Curves of the inhibition of  125 I-o-CRF binding to cell membranes at various dilutions of test drug are analyzed by the iterative curve fitting program LIGAND [P. J. Munson and D. Rodbard,  Anal. Biochem.  107:220 (1980)], which provides Ki values for inhibition which are then used to assess biological activity. 
     A compound is considered to be active if it has a K i  value of less than about 10000 nM for the inhibition of CRF. Compounds with a K i  less than 100 nM for the inhibition of CRF are desirable. A number of compounds of the invention have been made and tested in the above assay and shown to have K i  values less than 100 nM thus confirming the utility of the invention. 
     Inhibition of CRF-Stimulated Adenylate Cyclase Activity 
     Inhibition of CRF-stimulated adenylate cyclase activity was performed as described by G. Battaglia et al.  Synapse  1:572 (1987). Briefly, assays were carried out at 37° C. for 10 min in 200 ml of buffer containing 100 mM Tris-HCl (pH 7.4 at 37° C.), 10 mM MgCl 2 , 0.4 mM EGTA, 0.1% BSA, 1 mM isobutylmethylxanthine (IBMX), 250 units/ml phosphocreatine kinase, 5 mM creatine phosphate, 100 mM guanosine 5′-triphosphate, 100 nM oCRF, antagonist peptides (concentration range 10 −9  to 10 −6m ) and 0.8 mg original wet weight tissue (approximately 40-60 mg protein). Reactions were initiated by the addition of 1 mM ATP/ 32 P]ATP (approximately 2-4 mCi/tube) and terminated by the addition of 100 ml of 50 mM Tris-HCL, 45 mM ATP and 2% sodium dodecyl sulfate. In order to monitor the recovery of cAMP, 1 μl of [ 3 H]cAMP (approximately 40,000 dpm) was added to each tube prior to separation. The separation of [ 32 P]cAMP from [ 32 P]ATP was performed by sequential elution over Dowex and alumina columns. Recovery was consistently greater than 80%. 
     A compound of this invention was tested in this assay and found to be active; IC 50 &lt;10000 nM. 
     In vivo Biological Assay 
     The in vivo activity of the compounds of the present invention can be assessed using any one of the biological assays available and accepted within the art. Illustrative of these tests include the Acoustic Startle Assay, the Stair Climbing Test, and the Chronic Administration Assay. These and other models useful for the testing of compounds of the present invention have been outlined in C. W. Berridge and A. J. Dunn  Brain Research Reviews  15:71 (1990). 
     Compounds may be tested in any species of rodent or small mammal. Disclosure of the assays herein is not intended to limit the enablement of the invention. 
     Compounds of this invention have utility in the treatment of inbalances associated with abnormal levels of corticotropin releasing factor in patients suffering from depression, affective disorders, and/or anxiety. 
     Compounds of this invention can be administered to treat these abnormalities by means that produce contact of the active agent with the agent&#39;s site of action in the body of a mammal. The compounds can be administered by any conventional means available for use in conjunction with pharmaceuticals either as individual therapeutic agent or in combination of therapeutic agents. They can be administered alone, but will generally be administered with a pharmaceutical carrier selected on the basis of the chosen route of administration and standard pharmaceutical practice. 
     The dosage administered will vary depending on the use and known factors such as pharmacodynamic character of the particular agent, and its mode and route of administration; the recipient&#39;s age, weight, and health; nature and extent of symptoms; kind of concurrent treatment; frequency of treatment; and desired effect. For use in the treatment of said diseases or conditions, the compounds of this invention can be orally administered daily at a dosage of the active ingredient of 0.002 to 200 mg/kg of body weight. Ordinarily, a dose of 0.01 to 10 mg/kg in divided doses one to four times a day, or in sustained release formulation will be effective in obtaining the desired pharmacological effect. 
     Dosage forms (compositions) suitable for administration contain from about 1 mg to about 100 mg of active ingredient per unit. In these pharmaceutical compositions, the active ingredient will ordinarily be present in an amount of about 0.5 to 95% by weight based on the total weight of the composition. 
     The active ingredient can be administered orally is solid dosage forms, such as capsules, tablets and powders; or in liquid forms such as elixirs, syrups, and/or suspensions. The compounds of this invention can also be administered parenterally in sterile liquid dose formulations. 
     Gelatin capsules can be used to contain the active ingredient and a suitable carrier such as but not limited to lactose, starch, magnesium stearate, steric acid, or cellulose derivatives. Similar diluents can be used to make compressed tablets. Both tablets and capsules can be manufactured as sustained release products to provide for continuous release of medication over a period of time. Compressed tablets can be sugar-coated or film-coated to mask any unpleasant taste, or used to protect the active ingredients from the atmosphere, or to allow selective disintegration of the tablet in the gastrointestinal tract. 
     Liquid dose forms for oral administration can contain coloring or flavoring agents to increase patient acceptance. 
     In general, water, pharmaceutically acceptable oils, saline, aqueous dextrose (glucose), and related sugar solutions and glycols, such as propylene glycol or polyethylene glycol, are suitable carriers for parenteral solutions. Solutions for parenteral administration preferably contain a water soluble salt of the active ingredient, suitable stabilizing agents, and if necessary, butter substances. Antioxidizing agents, such as sodium bisulfite, sodium sulfite, or ascorbic acid, either alone or in combination, are suitable stabilizing agents. Also used are citric acid and its salts, and EDTA. In addition, parenteral solutions can contain preservatives such as benzalkonium chloride, methyl- or propyl-paraben, and chlorobutanol. 
     Suitable pharmaceutical carriers are described in “Remington&#39;s Pharmaceutical Sciences”, A. Osol, a standard reference in the field. 
     Useful pharmaceutical dosage-forms for administration of the compounds of this invention can be illustrated as follows: 
     Capsules 
     A large number of units capsules are prepared by filling standard two-piece hard gelatin capsules each with 100 mg of powdered active ingredient, 150 mg lactose, 50 mg cellulose, and 6 mg magnesium stearate. 
     Soft Gelatin Capsules 
     A mixture of active ingredient in a digestible oil such as soybean, cottonseed oil, or olive oil is prepared and injected by means of a positive displacement was pumped into gelatin to form soft gelatin capsules containing 100 mg of the active ingredient. The capsules were washed and dried. 
     Tablets 
     A large number of tablets are prepared by conventional procedures so that the dosage unit was 100 mg active ingredient, 0.2 mg of colloidal silicon dioxide, 5 mg of magnesium stearate, 275 mg of microcrystalline cellulose, 11 mg of starch, and 98.8 mg lactose. Appropriate coatings may be applied to increase palatability or delayed adsorption. 
     The compounds of this invention may also be used as reagents or standards in the biochemical study of neurological function, dysfunction, and disease.