Dyna-1 Model Card

Dyna-1 is a model introduced in our paper, "Learning millisecond protein dynamics from what is missing in NMR spectra".

Given a sequence and/or structure, Dyna-1 will predict the probability that each residue experiences micro-millisecond motions.

Dyna-1 was achieved using the esm3-sm-open-v1 weights from ESM-3. Inference with this model is subject to the EvolutionaryScale Cambrian Non-Commercial License Agreement of the ESM-3 Model and requires read permission of the weights found here. We also make available an alternate version of Dyna-1 that uses ESM-2 embeddings; use of this model is subject to a Non-Commercial License Agreement.

If you are using our code, datasets, or model, please use the following citation:

@article {Dyna-1,
    author = {Wayment-Steele, Hannah K. and El Nesr, Gina and Hettiarachchi, Ramith and Kariyawasam, Hasindu and Ovchinnikov, Sergey and Kern, Dorothee},
    title = {Learning millisecond protein dynamics from what is missing in NMR spectra},
    year = {2025},
    doi = {10.1101/2025.03.19.642801},
    journal = {bioRxiv}
}