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Orbital Inflammatory Disease. Idiopathic orbital inflammatory syndrome (IOIS) is a diagnosis of exclusion, requiring an evaluation to rule out other causes of orbital disease. Orbital MRI is the test of choice, but serologic studies are necessary to exclude a systemic etiology. Biopsy is usually not indicated at presentation, as the risk of causing damage to vital structures within the orbit outweighs the benefits. Patients unresponsive to therapy or those with multiple recurrences should be biopsied. The first-line treatment is corticosteroids, which may be tapered over several months. Although data is limited, radiotherapy is indicated for patients who fail to respond to steroids, or who have a rapidly progressive course. For those patients who are refractory to both corticosteroids and radiotherapy, anecdotal reports have supported the use of chemotherapeutic agents such as cyclophosphamide, methotrexate, and cyclosporine.
/* Firewall Builder Copyright (C) 2002-2011 NetCitadel, LLC Author: Vadim Kurland vadim@fwbuilder.org This program is free software which we release under the GNU General Public License. You may redistribute and/or modify this program under the terms of that license as published by the Free Software Foundation; either version 2 of the License, or (at your option) any later version. This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details. To get a copy of the GNU General Public License, write to the Free Software Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA 02111-1307 USA */ #include "splitByNetworkZonesForRE.h" #include "Helper.h" #include "fwbuilder/Resources.h" #include "fwbuilder/FWObjectDatabase.h" #include "fwbuilder/RuleSet.h" #include "fwbuilder/Interface.h" #include "fwcompiler/Compiler.h" using namespace libfwbuilder; using namespace fwcompiler; using namespace std; /* * create new rule and associate it with given interface. If we * already have a rule associated with it, then just add Address to * the rule element of that existing rule. */ void splitByNetworkZonesForRE::AddToInterface( int interface_id, Address *addr, Rule *rule) { Rule *new_rule; RuleElement *new_re; new_rule = rules[interface_id]; if (new_rule==nullptr) { new_rule = Rule::cast(compiler->dbcopy->create(rule->getTypeName())); compiler->temp_ruleset->add(new_rule); new_rule->duplicate(rule); rules[interface_id] = new_rule; new_re = RuleElement::cast(new_rule->getFirstByType(re_type)); new_re->clearChildren(); new_re->setAnyElement(); } new_re = RuleElement::cast(new_rule->getFirstByType(re_type)); new_re->addRef( addr ); } bool splitByNetworkZonesForRE::processNext() { Helper helper(compiler); Rule *rule = prev_processor->getNextRule(); if (rule==nullptr) return false; RuleElement *re = RuleElement::cast(rule->getFirstByType(re_type)); if (re->size()==1) { tmp_queue.push_back(rule); return true; } rules.clear(); std::list<FWObject*> cl; for (list<FWObject*>::iterator i1=re->begin(); i1!=re->end(); ++i1) { Address *a = Address::cast(FWReference::getObject(*i1)); assert(a!=nullptr); try { int interface_id = helper.findInterfaceByNetzone(a); AddToInterface(interface_id, a, rule); } catch (string err) { // could not find interface with netzone to match address 'a' // will assign rule to all interfaces. Act as if all interfaces // had network zone 'any' and each matches this address. // issue warning only if platform uses netwrk zones. bool supports_network_zones = Resources::getTargetCapabilityBool( compiler->fw->getStr("platform"), "network_zones"); if (supports_network_zones) compiler->warning(rule, err); FWObjectTypedChildIterator i = compiler->fw->findByType(Interface::TYPENAME); for ( ; i!=i.end(); ++i) { Interface *ifs = Interface::cast(*i); AddToInterface(ifs->getId(), a, rule); } } } for (std::map<int,Rule*>::iterator i=rules.begin(); i!=rules.end(); ++i) { tmp_queue.push_back((*i).second); } return true; }
Q: Python md5 hashes of same gzipped file are inconsistent I am trying to zip a file using the python module gzip, and then hash the gzipped filed using hashlib. I have the following code: import hashlib import gzip f_name = 'read_x.fastq' for x in range(0,3): file = open(f_name, 'rb') myzip = gzip.open('test.gz', 'wb', compresslevel=1) n = 100000000 try: print 'zipping ' + str(x) for chunk in iter(lambda: file.read(n), ''): myzip.write(chunk) finally: file.close() myzip.close() md5 = hashlib.md5() print 'hashing ' + str(x) with open('test.gz', 'r') as f: for chunk in iter(lambda: f.read(n), ''): md5.update(chunk) print md5.hexdigest() print '\n' which I thought should simply zip the file, hash it and display the same output hash three times in a row. However, the output I get is: zipping 0 hashing 0 7bd80798bce074c65928e0cf9d66cae4 zipping 1 hashing 1 a3bd4e126e0a156c5d86df75baffc294 zipping 2 hashing 2 85812a39f388c388cb25a35c4fac87bf If I leave out the gzip step, and just hash the same gzipped file three times in a row, I do indeed get the same output three times: hashing 0 ccfddd10c8fd1140db0b218124e7e9d3 hashing 1 ccfddd10c8fd1140db0b218124e7e9d3 hashing 2 ccfddd10c8fd1140db0b218124e7e9d3 Can anyone explain what is going on here? The issue must be that the gzip process is different each time. But as far as I knew, the DEFLATE algorithm is Huffman coding followed by LZ77 (a form of run-length-encoding) or LZ77 followed by Huffman, and therefore given identical input should produce identical output. A: There are several reasons why compressing the exact same content will produce different gzip outputs: compression level. This you can control via the compress level parameter. The name of the original file which is in the header. This you can control if you use the gzip.GzipFile api rather than the gzip.open api. The modification time which is also in the header and can also be controlled with the gzip.GzipFile api. So here is a piece of code that demonstrated the wrong and the right way to get reproducible output from python gzip: import hashlib import gzip f_name = '/etc/passwd' output_template = '/tmp/test{}.gz' def digest(filename: str) -> str: md5 = hashlib.md5() with open(output_filename, 'rb') as f: for chunk in iter(lambda: f.read(block_size), b''): md5.update(chunk) return md5.hexdigest() print("The default way - non identical outputs") for x in range(0,3): input_handle = open(f_name, 'rb') output_filename = output_template.format(x) myzip = gzip.open(output_filename, 'wb') block_size = 4096 try: for chunk in iter(lambda: input_handle.read(block_size), b''): myzip.write(chunk) finally: input_handle.close() myzip.close() print(digest(output_filename)) print("The right way to get identical outputs") for x in range(3,6): input_handle = open(f_name, 'rb') output_filename = output_template.format(x) myzip = gzip.GzipFile( filename='', # do not emit filename into the output gzip file mode='wb', fileobj=open(output_filename, 'wb'), mtime=0, ) block_size = 4096 try: for chunk in iter(lambda: input_handle.read(block_size), b''): myzip.write(chunk) finally: input_handle.close() myzip.close() print(digest(output_filename))
Q: MVC 404 Errors - Still New So, I'm getting a 404 error on my current MVC project on submit. I'm new to MVC, so I'm likely doing something exceptionally stupid. Here's the relevant code... <%@ Page Title="Pies" Language="C#" Inherits="System.Web.Mvc.ViewPage" MasterPageFile="~/site.master" %> <asp:Content ContentPlaceHolderID="MainContent" runat="server"> <h1>Oh Boy Pies</h1> <p>Tell us about the pies!</p> <form action="Process" method="post"> <div class="inputdiv"> <span class="spaced">Name:</span> <%= Html.TextBox("name") %> <%= Html.ValidationMessage("name", "*") %> </div> </form> And the relevant handler is... using System; using System.Collections.Generic; using System.Linq; using System.Web; using System.Web.Mvc; using System.Web.Mvc.Ajax; namespace tabdemo.Controllers { public class HomeController : Controller { public ActionResult Index () { ViewData ["Message"] = "Demo!"; return View (); } public ActionResult Process (FormCollection form) { Response.Write (form ["name"]); Response.End (); return Redirect ("Index.aspx"); } } } Also, can people explain how this would be implemented using TextBoxFor, for example? I've seen examples of it, but I don't understand it at all. edit: Here's the masterpage <%@ Master Language="C#" Inherits="System.Web.Mvc.ViewMasterPage" %> <!DOCTYPE html> <html xmlns="http://www.w3.org/1999/xhtml"> <head runat="server"> <asp:ContentPlaceHolder ID="head" runat="server"> </asp:ContentPlaceHolder> </head> <body> <asp:ContentPlaceHolder ID="MainContent" runat="server"> </asp:ContentPlaceHolder> </body> </html> A: it should be return RedirectToAction("Index"). MVC does not use PAGES, instead relies on Controller to route the request. Controllers return the View, or Redirect to another Controller, which renders the view. EDIT And yes, the action method was incorrect(just saw) <form action="/Home/Process" method="post"> <div class="inputdiv"> <span class="spaced">Name:</span> <%= Html.TextBox("name") %> <%= Html.ValidationMessage("name", "*") %> </div> </form>
Instacart (YC S12) wants to be Amazon with 1 hour delivery - apoorvamehta http://techcrunch.com/2012/08/01/instacart/ ====== cs702 I'd love to have this service at home, so I'm (selfishly) hoping Instacart becomes hugely successful! That said, I can't help but wonder whether the company will find a business model with sustainable economics. A lot of really smart people have tried and failed to accomplish this sort of thing before. For example, Amazon invested $60 million in Kozmo.com back in the late 90's, and they couldn't make it work. (Kozmo.com ended up raising a quarter billion dollars before shutting down.)[1] The main challenge is that same-day, point-to-point delivery is very expensive -- a complex problem. (Most delivery systems in use today rely on some kind of hub-and-spoke design.) Perhaps the wide adoption of smart phones will make point-to-point delivery economically viable for Instacart -- e.g., by giving the company cost-effective access to underused delivery vehicles as needed to satisfy the ebbs and flows of consumer demand. I'm curious to see if and how Instacart can pull it off. \-- [1] <http://en.wikipedia.org/wiki/Kozmo.com#History> ~~~ apoorvamehta While I agree that a lot of smart people have tried this before (Kozmo.com, WebVan, etc), I believe that there are significant differences in the approach that we are taking. Specifically, Kozmo.com was founded in an era where you could IPO without having profits. Having that mentality from day one allowed them to make huge concessions to users such as give them free delivery on everything, and not have a minimum order. For example, you could pay $1.50 for a gum on Kozmo and get it delivered to you within an hour. WebVan, on the other hand spend $1B on building it's own warehouses and fulfillment infrastructure. Learning from those companies, we have done a lot of things differently. For starters, there is a minimum order of $10. There is a delivery fee of $3.99 for 3 hours and $9.99 for 1 hour. (Would you not pay $4 for someone to do all your groceries?) And, we do not hold any inventory - all of it is sourced directly from local retailers. It is also important to mention that the time that we live in is very different. People are a lot more comfortable adding their credit card information on web/mobile. Not to mention, the access to smart phones that people have gives customers the ability to shop from anywhere - office, couch, next to the fridge. We believe we are different from the companies that have tried this in the past. And, we hope we are live in your hometown very soon. (edits to follow) ~~~ cs702 apoorvamehta: thank you for your prompt, articulate response. The logistical challenges look daunting to me. My recollection is that the problem of coordinating and optimizing deliveries in such a point-to-point system with time constraints is NP-hard (I could be wrong about this, but that's my recollection). Then one has to deal with all sorts of real-world problems like order-fulfillment errors and substitutions (intentional and otherwise), constant shrinkage of merchandise, etc. Obviously there's some price at which the service can be profitable, but I'm not sure it's $4. (Consider that the former CTO of Kozmo, Chris Siragusa, has been running a one-hour, point-to-point $3 delivery service for a number of years, MaxDelivery.com, but he has kept the service restricted to a relatively small, dense area in lower Manhattan, making the economics worthwhile.) In any case, I sure hope you're right! ~~~ apoorvamehta cs702, your recollection is correct. Last mile logistics is a hard problem. Not to mention, order-fulfillment errors and substitutions do happen. However, we believe these are solvable. It comes down to two things - one is proper training of the drivers and using technology as much as possible to eliminate chances of errors. That is too high level. Let me explain more clearly for one specific case of order substitution. Since we are focusing on a niche (groceries), our system has already calculated the substitutes of items. We know how to substitute a Store Brand Ketchup to Heinz IF needed. A lot of what I know about logistics is from my time at Amazon Supply Chain, where I dealt specifically with the challenge of fulfilling packages to the customer from AMZN FCs (aka warehouses). And, at Instacart we believe we can have the same efficiencies IF we model the stores in a city just like AMZN modeled warehouses across the world. ~~~ gav > And, at Instacart we believe we can have the same efficiencies IF we model > the stores in a city just like AMZN modeled warehouses across the world. My supply chain experience comes almost entirely from third-party shipping (somewhat) similar to this. In my opinion it's considerably harder and more problematic than dealing with your own fulfillment centers. You give up a lot of control. There's a whole slew of problems: * Integration with other people's systems, which are often horribly dysfunctional, require manual intervention (such as re-keying), and can't give you the data you need (e.g. stock levels) * The fact that you have to rely on staff that don't work for you, and either don't care about you, or in some cases deliberately sabotage your orders * You're often relying on a vendor who is also a direct-competitor in this or other channels I think a good model is Seamless. They act as the middleman just as you do, however it's the restaurant's name you see, rate, and attach reputation to. This gives them the incentive to provide good service. If you're shielding your vendors from the effects of providing bad service, then there's less incentive to provide good service. I think it's an interesting problem to solve. Though here in NYC we're spoiled by a large range of next-day options; I personally use services such as Fresh Direct, Amazon (Prime and "Shop 'n Save"), Soap, and USQ Wines. ------ jhuckestein It'll be interesting to see how this plays out against Amazon's push into same-day delivery. Amazon is setting up local distribution centers of their own. Instacart is using existing distribution centers (i.e. retail stores). Both companies need to figure out how to best deliver items locally. This is a big logistical challenge (but luckily it's well researched). In addition, Amazon needs to predict demand locally and ship items to a local distribution center. Instacart can leverage existing supply chains but has to pay a premium for it. If Instacart is willing to operate at a loss for a while, they might actually have an advantage over Amazon and can fully focus on getting the local delivery part of the equation right. Very exciting stuff and congrats on the launch! Disclaimer: I met Apoorva a few weeks ago and have been happily using the service since. I'm extremely impressed by how he managed to do all of this essentially alone and can't wait to see what's next. Edit: typos ------ kevinh The techcrunch article title is misleading - they don't want to be Amazon; they're not maintaining warehouses (which may prevent them from crashing like Webvan). They're effectively delivery people that you hire to bring you products from local stores, which is a _very_ different market. Regardless, there are a lot of dead companies that litter the path for a product like this. I'd be surprised if Instacart succeeds. ------ vgurgov This is the most useful service i discovered i recent months. period. I seriously recommend this to anyone in SF. I dont remember the last time i went shopping for groceries. It already saved me tons of hours and money. no- brainer. disclaimer: my company is in the same YC batch and I know Apoorva personally and was happy to get early access to service. ------ alanfalcon I love that the website doesn't shoehorn me into a crappy mobile version when I load it, but what happens now is that I get a picture of an iPhone and apparently nothing else—it's not at all intuitive for me to think to scroll horizontally to find the content of the web page, especially with the hidden- by-default scroll bars on the iPhone. To clarify, the horizontal scroll bar that appeared when scrolling vertically while "looking for the rest of the page" was hidden by a thumb for me. I only barely thought to check horizontal scrolling before giving up on the page as somehow broken on my iPhone. Deatil of what I see (on the left) vs what I probably should see (on the right, after zooming manually): <http://i.imgur.com/1Yjfi.jpg> ~~~ apoorvamehta fixed now. thanks for the heads up :) ------ zeroonetwothree If they were to do alcohol delivery this could be really big. Even if they charge more for it (say $20) it's going to be extremely popular. ~~~ anthemcg I've ordered alcohol with the app... ------ rokhayakebe This gets even better and it will save tons of money when I can create a bag, save it, then simply press one button to re-order. ~~~ apoorvamehta Coming up in the next iteration (i.e. in a day or two) :) ------ applefanner It's a great idea, in theory. But who's the target market? Wealthy professionals have a wife to bring them stuff or have personal assistants (hard to believe in the world of dual income households, but I have friends that do just this). Young, less wealthy professionals just go pick up the items themselves or have friends pick them up for them. College kids aren't going to pay for such a service, they enjoy taking a break from studying to go pick up something. And yes, I know, I'm sure there are stay at home husbands that do errands for their wealthy professional wives, I just don't know of any. ------ sethbannon Grocery shopping for the lazy AND impatient? Yes please. ------ anthemcg I have been using past few week while it was in Alpha and I got say, its my favorite service for drink runs like sodas/juices/liquors. Def going to become a regular user. Gonna be following with much interest. Also, to add to the conversation.It all about timing, right? Now with Amazon being as big as it is and we see companies like Rewinery, Exec, Postmates smashing into this on-demand local delivery space. The time seems ideal for a company like Instacart. I do miss WebVan though. ------ SoftwareMaven Monday I was having a conversation with a coworker about the looming major showdown between Amazon and Walmart. My take was Walmart should offer _exactly_ this, allowing them to leverage their massive supply chain and warehouses in every city with more than 5000 people (aka "The Walmart"). Awesome to see a startup rising to the challenge. ------ imjk Wasn't there a documentary about this somewhere back in the day that came to define the dot-com bubble? ~~~ apoorvamehta The documentary was talking about Kozmo.com, which had several issues in their business model including no minimum order size or delivery fees. ------ makeee I've been using instacart a lot lately and it's awesome. I really think this is going to big. ------ reddickulous How can they make money delivering for $9.99? I guess the item prices are jacked up a little. ------ DanielRibeiro Sounds nice. I know some people have been using Exec (YC W12) to do this, but instacart is much cheaper. The only thing that takes all the excitement for me is that it does not have a android version OR a web one.... ------ nukethefridge This looks great. Today I'm sick WFH and could really use some meds delivered. I signed up for an invite... what is the process/wait time like? I may have to try something else if I'll need to wait too long. ~~~ danielweber Unfortunately for you I would expect medicine to be something they won't deliver. Alcohol, too. ~~~ nukethefridge I was thinking more like cough drops and advil, not prescriptions... would those still be outside the acceptable list of things to deliver? ~~~ dafnap I ordered Advil through instacart. Really saved me. ------ kfk Have you looked at the financials of this? 10$ for 1 hr delivery means that either the carrier is paid less than that hourly(and I guess at least 20% less than that) or he is supposed to deliver more than 1 package per hour. Considering transportation costs and idle time, I am not sure this will work smoothly. It will work if there is a list of carriers ready to drop what they are doing to go buy groceries and make some money. Basically, it will work in cities with lots and lots of students... ------ Philadelphia Doesn't Amazon plan to be Amazon with 1 hour delivery? ~~~ apoorvamehta same day is different than 1 hour. not to mention, you cannot order perishables from Amazon. ~~~ jlgreco <http://fresh.amazon.com> ~~~ graue Only available in Seattle. ------ RobAtticus This kind of seems like a rip off of Postmates' "Get It Now", no? <http://postmates.com/getitnow/> ------ samstave Kozmo.com of the new era bubble. This will be interesting. ------ antidaily Peapod but faster? ~~~ tg3 Kozmo.com, but with a saner business model. ~~~ mmmmax I remember Kozmo.com! The big difference now: Smartphones ------ dinkumthinkum I can barely get a pizza delivered in an hour, and they've been doing that since the 1970s (I guess, I have no idea when pizza delivery started). Do I have to worry about Instacart maniacs driving like banshees on the road? ------ binarysolo This feels like a specialized TaskRabbit kind of thing (like what they tried to do with the $10 delivery for In-N-Out anywhere in SF). Could be workable if there's enough customers. ------ mochizuki If something is located within an hour of me I could just drive and get it, or use a local delivery service. I use the internet to buy extra weird stuff that I can't get locally. ------ tianshuo Groceries+short delivery window... sounds like webvan ;-P <http://en.wikipedia.org/wiki/Webvan> ------ mthmohan Love the idea.. Possibilities around POS data and Nielsen like services are obvious extensions.. Good luck!! ------ rahulnb Better than Peapod and Kozmo, the time for such a service is definitely now in the mobile driven world. ------ endeavor Are you guys limiting the invites? I'd love to check it out but haven't received my invite yet. ------ HorizonXP Congrats Apoorva! Glad to see us 08 Elecs trying to change the world for the better. ------ chris123 Who delivers? Is this a P2P marketplace (like Taskrabbit, etc?)? ------ tylerlh Looking forward to giving this a try. Best of luck! ------ shiftb This is a brilliant idea. Hard, but worth doing. ~~~ bezaorj I truly want this on my city, and I guess a lot of people are thinking the same, so the model has a lot of potential! ------ adv0r Milkplease (refused by YC) is more promising and we are trying to be faster [http://www.springwise.com/retail/italy-site-lets-users- crowd...](http://www.springwise.com/retail/italy-site-lets-users-crowdsource- small-last-minute-grocery-deliveries/)
<!doctype html> <html> <head> <meta charset="UTF-8"> <meta name="viewport" content="width=device-width, initial-scale=1.0,maximum-scale=1.0, user-scalable=no"> <title>Hostino - Documentation</title> <link rel="stylesheet" type="text/css" href="assets/css/bootstrap.min.css"> <link rel="stylesheet" type="text/css" href="assets/css/font-awesome.min.css"> <link rel="stylesheet" type="text/css" href="assets/css/prettify.css"> <link rel="stylesheet" type="text/css" href="assets/css/style.css"> </head> <body> <div id="header" class="container-fluid"> <div class="row"> <div class="col-xs-12"> <div class="doc-title"><div class="glyph-icon flaticon-document-1"></div>Hostino - Documentation</div> </div> </div> </div> <div id="content" class="container-fluid"> <div class="row"> <div class="col-xs-12 col-md-3" style="padding:0;"> <div class="menu-holder"> <ul class="main-menu"> <li><a href="#html" class="active"><i class="fa fa-angle-right" aria-hidden="true"></i>HTML Structure</a></li> <li><a href="#css"><i class="fa fa-angle-right" aria-hidden="true"></i>CSS & JavaScript</a></li> <li><a href="#theme"><i class="fa fa-angle-right" aria-hidden="true"></i>Switch the Style</a></li> <li><a href="#logo"><i class="fa fa-angle-right" aria-hidden="true"></i>Logo & Menu</a></li> <li><a href="#top-content"><i class="fa fa-angle-right" aria-hidden="true"></i>Top Content</a></li> <li><a href="#icons"><i class="fa fa-angle-right" aria-hidden="true"></i>Icons & text</a></li> <li><a href="#pricing"><i class="fa fa-angle-right" aria-hidden="true"></i>Pricing tables</a></li> <li><a href="#apps"><i class="fa fa-angle-right" aria-hidden="true"></i>Apps Icons & text</a></li> <li><a href="#testimonials"><i class="fa fa-angle-right" aria-hidden="true"></i>Testimonials</a></li> <li><a href="#photo-slider"><i class="fa fa-angle-right" aria-hidden="true"></i>Photo slider</a></li> <li><a href="#address"><i class="fa fa-angle-right" aria-hidden="true"></i>Footer - address & social</a></li> <li><a href="#whmcs"><i class="fa fa-angle-right" aria-hidden="true"></i>WHMCS Theme Installation</a></li> </ul> </div> </div> <div class="col-xs-12 col-md-9 content"> <h3 id="html">HTML Structure</h3> <p>The template is based on bootstrap library, please read more about bootstrap here: <a href="http://getbootstrap.com/getting-started/" target="_blank">http://getbootstrap.com/getting-started/</a> To edit the template, a very basic knowledge in dealing with bootstrap is required. </p> <p>The Html file can be edited in any text editor, best example is Adobe Dreamweaver. </p> <p>Hostio template structure is based on bootstrap layout, the page is separated in rows, every row created like the following figure: </p> <img src="assets/images/doc.jpg"> <br> <p>The template is arranged in sections, each section(div) has an id, Ex: "mainNav", "top-content", "pricing", ...etc</p> <p><b>Note:</b> for the WHMCS, the same layout can be found in "header.tpl".</p> <pre class="prettyprint"> &lt;div id="top-content" class="container-fluid"&gt; ... &lt;div id="info" class="container-fluid"&gt; ... &lt;div id="features" class="container-fluid"&gt; ... &lt;div id="pricing" class="container-fluid"&gt; ... &lt;div id="apps" class="container-fluid"&gt; ... &lt;div id="testimonials" class="container-fluid"&gt; ... &lt;div id="footer" class="container-fluid"&gt; ...</pre> <h3 id="css">CSS</h3> <p>There are four CSS files in the template. First is "bootstrap.min.css", used for layout — originally in bootstrap, the other files are "font-awesome.min.css", "slick.css" and "style.css" is used for style customisation, where the texts, colors, backgrounds and font styles can be changed.</p> <p> We arrange the styles according to the order of the tags in the html. </p> <pre class="prettyprint">/*------------------------------------------------------------------ [Table of contents] 1. General Styles. 2. Header Section Styles. 3. Top Content Section Styles. 4. Info Section Styles 5. Features Section Styles. 6. Pricing Section Styles. 7. Apps Section Styles. 8. Testimonials Section Styles. 9. More Features Section Styles. 10. Get Started Section Styles. 11. Footer Section Styles. 12. Inner Pages Styles. 13. Responsive Styles. -------------------------------------------------------------------*/</pre> <h3 id="javascript">JavaScript</h3> <p>This template imports six Javascript files.</p> <ul> <li>"jquery.min.js": jQuery is a Javascript library that greatly reduces the amount of code that you must write.</li> <li>"bootstrap.min.js": Bootstrap is the most popular Javascript framework for developing responsive, mobile first projects on the web.</li> <li>"paper-full.min.js": Is an open source vector graphics scripting framework that runs on top of the HTML5 Canvas.</li> <li>"slick.min.js": slick is a responsive carousel jQuery plugin that supports multiple breakpoints, CSS3 transitions, touch events/swiping & much more!</li> <li>"metaball.js": the animation file.</li> <li>"main.js": Our custom javascript code.</li> </ul> <h3 id="theme">Switch the Style</h3> <p>To switch the style to the other style, simply add this code to the head of the page after all styles links as follow:</p> <pre class="prettyprint"> &lt;link rel=&quot;stylesheet&quot; type=&quot;text/css&quot; href=&quot;css/blue-grey.css&quot;&gt;</pre> <p>To be look like this:</p> <pre class="prettyprint"> &lt;link rel=&quot;stylesheet&quot; type=&quot;text/css&quot; href=&quot;css/bootstrap.min.css&quot;&gt; &lt;link rel=&quot;stylesheet&quot; type=&quot;text/css&quot; href=&quot;css/font-awesome.min.css&quot;&gt; &lt;link rel=&quot;stylesheet&quot; type=&quot;text/css&quot; href=&quot;css/slick.css&quot;&gt; &lt;link rel=&quot;stylesheet&quot; type=&quot;text/css&quot; href=&quot;css/style.css&quot;&gt; &lt;link rel=&quot;stylesheet&quot; type=&quot;text/css&quot; href=&quot;css/blue-grey.css&quot;&gt;</pre> <p>For the WHMCS, add this code to the "head.tpl" file in the "includes" folder.</p> <pre class="prettyprint"> &lt;link href=&quot;{$WEB_ROOT}/templates/{$template}/css/blue-grey.css&quot; rel=&quot;stylesheet&quot;&gt;</pre> <p>And this should be look like the following code:</p> <pre class="prettyprint"> &lt;link href=&quot;{$WEB_ROOT}/templates/{$template}/css/custom.css&quot; rel=&quot;stylesheet&quot;&gt; &lt;link href=&quot;{$WEB_ROOT}/templates/{$template}/css/styles-modified.css&quot; rel=&quot;stylesheet&quot;&gt; &lt;link href=&quot;{$WEB_ROOT}/templates/{$template}/css/slick.css&quot; rel=&quot;stylesheet&quot;&gt; &lt;link href=&quot;{$WEB_ROOT}/templates/{$template}/css/style.css&quot; rel=&quot;stylesheet&quot;&gt; &lt;link href=&quot;{$WEB_ROOT}/templates/{$template}/css/blue-grey.css&quot; rel=&quot;stylesheet&quot;&gt;</pre> <h3 id="logo">Logo</h3> <p>To change the logo, replace the img src="" with the logo url, consider that the dimentions of the logo must be width: 194 px ×  height: 34px.</p> <pre class="prettyprint">&lt;img class="logo" src="images/logo.png" alt="Hostino"&gt;</pre> <h3 id="menu">Menu</h3> <p>To change the menu links, simply edit this code.</p> <pre class="prettyprint"> &lt;ul class=&quot;nav navbar-nav navbar-right&quot;&gt; &lt;li&gt;&lt;a href=&quot;index.html&quot;&gt;Home&lt;/a&gt;&lt;/li&gt; &lt;li class=&quot;dropdown&quot;&gt; &lt;a href=&quot;pages.html&quot;&gt;Pages &lt;span class=&quot;caret&quot;&gt;&lt;/span&gt;&lt;/a&gt; &lt;ul class=&quot;dropdown-menu&quot;&gt; &lt;li&gt;&lt;a href=&quot;about.html&quot;&gt;About us&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a href=&quot;webhosting.html&quot;&gt;Web hosting plans&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a href=&quot;domain.html&quot;&gt;Domain names&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a href=&quot;blog.html&quot;&gt;Blog&lt;/a&gt;&lt;/li&gt; &lt;/ul&gt; &lt;/li&gt; &lt;li&gt;&lt;a href=&quot;support.html&quot;&gt;Support portal&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a href=&quot;contact.html&quot;&gt;Contact us&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a class=&quot;signin-button&quot; href=&quot;signin.html&quot;&gt;Sign in&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a class=&quot;chat-button&quot; href=&quot;#&quot;&gt;Chat now&lt;/a&gt;&lt;/li&gt; &lt;/ul&gt;</pre> <br> <p>Add a link to "Chat now" button, by replacing the # in href="#" </p> <pre class="prettyprint">&lt;li&gt;&lt;a class=&quot;chat-button&quot; href=&quot;#&quot;&gt;Chat now&lt;/a&gt;&lt;/li&gt;</pre> <h3 id="top-content">Top Content</h3> <p>There are three slides in the top of the home page, every slide has "title" attribute, the title value will shown as slide title, to change it simply edit the following code:</p> <pre class="prettyprint"> &lt;div id=&quot;main-slider&quot;&gt; &lt;div class=&quot;slide domainsearch-slide&quot; title=&quot;Welcome !&quot;&gt; ... &lt;/div&gt; &lt;div class=&quot;slide info-slide1&quot; title=&quot;Features&quot;&gt; ... &lt;/div&gt; &lt;div class=&quot;slide info-slide2&quot; title=&quot;Get started&quot;&gt; ... &lt;/div&gt; &lt;/div&gt;</pre> <p>Each slide has simple content, the first one has domain search input with some text, the text can be edited by modifying the following code:</p> <pre class="prettyprint"> &lt;div class=&quot;b-title&quot;&gt;Find a personal or professional domain&lt;br&gt; that stands out.&lt;/div&gt;</pre> <p>And the other slides has image, text and button. You can edit it easily as follow:</p> <pre class="prettyprint"> &lt;div class=&quot;image-holder&quot;&gt;&lt;img src=&quot;images/main-slide-img1.png&quot; alt=&quot;&quot; /&gt;&lt;/div&gt; &lt;div class=&quot;text-holder&quot;&gt;Take your career to the next level&lt;br&gt; Get your website today.&lt;/div&gt; &lt;div class=&quot;button-holder&quot;&gt;&lt;a href=&quot;signup.html&quot; class=&quot;blue-button&quot;&gt;Sign up now&lt;/a&gt;&lt;/div&gt;</pre> <h3 id="icons-text">Icons & text</h3> <p>This way of the layout is repeated in many different places in the template and can be edited easily as follow:</p> <p>You can change the icon, title and details text by editing this code for each one.</p> <p>You can use FontAwesome icons. Assume you needed twitter icon. To do that, replace this "fa fa-star" with this "fa fa-twitter".</p> <p>To relplace the icon with an image, replace this code &lt;i class="fa fa-star"&gt; with this &lt;img src="image/image.png" width"60" height="60" /&gt; and modify the src="" with the image url.</p> <pre class="prettyprint"> &lt;div class=&quot;mfeature-box&quot;&gt; &lt;div class=&quot;mfeature-icon&quot;&gt; &lt;div class=&quot;icon-bg&quot;&gt;&lt;img src=&quot;images/clouds-light.png&quot; alt=&quot;&quot; /&gt;&lt;/div&gt; &lt;i class=&quot;fa fa-star&quot;&gt;&lt;/i&gt; &lt;/div&gt; &lt;div class=&quot;mfeature-title&quot;&gt;Uptime 100%. Guaranteed.&lt;/div&gt; &lt;div class=&quot;mfeature-details&quot;&gt;Mauris at libero sed justo pretium maximus ac non ex. Donec sit amet ultrices dolo.&lt;/div&gt; &lt;/div&gt;</pre> <p>Make sure to repeat the same modifications in this code as well.</p> <h3 id="pricing">Pricing tables</h3> <p>Every Pricing table start with this code. In the code there is class "pr-color1", this class is changing the main color of the table, there are three colors to use, "pr-color1", "pr-color2", "pr-color3".</p> <pre class="prettyprint">&lt;div class=&quot;pricing-box pr-color1&quot;&gt;</pre> <p>You can add "Recommended" icon at the top of the table by adding "recommended" class next to other classes as follow.</p> <pre class="prettyprint">&lt;div class=&quot;pricing-box pr-color1 recommended&quot;&gt;</pre> <p>This code is for the pricing table in "index.html","webhosting.html" pages. The title, price and the details can be changed easily </p> <pre class="prettyprint"> &lt;div class=&quot;pricing-box pr-color1&quot;&gt; &lt;div class=&quot;pricing-title&quot; title=&quot;Starter&quot;&gt;Starter&lt;/div&gt; &lt;div class=&quot;pricing-box-body&quot;&gt; &lt;div class=&quot;pricing-amount&quot;&gt; &lt;div class=&quot;price&quot;&gt; &lt;span class=&quot;currency&quot;&gt;$&lt;/span&gt;&lt;span class=&quot;amount&quot;&gt;8.3&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;duration&quot;&gt;monthly&lt;/div&gt; &lt;/div&gt; &lt;div class=&quot;pricing-details&quot;&gt; &lt;ul&gt; &lt;li&gt;Storage &mdash; 10 GB&lt;/li&gt; &lt;li&gt;Bandwidth ( Traffic ) &mdash; 15 GB&lt;/li&gt; &lt;li&gt;Domain name &mdash; Free!&lt;/li&gt; &lt;li&gt;Ram &mdash; 128 MB&lt;/li&gt; &lt;li&gt;Subdomains &mdash; 10 GB&lt;/li&gt; &lt;li&gt;Sharing data&lt;/li&gt; &lt;li&gt;Unlimited Email Account&lt;/li&gt; &lt;li class=&quot;not-supported&quot;&gt;Support 24/7&lt;/li&gt; &lt;li class=&quot;not-supported&quot;&gt;One Click Install&lt;/li&gt; &lt;li class=&quot;not-supported&quot;&gt;Private SSL &amp; IP&lt;/li&gt; &lt;li class=&quot;not-supported&quot;&gt;Free VoIP Phone Service&lt;/li&gt; &lt;/ul&gt; &lt;/div&gt; &lt;div class=&quot;pricing-button&quot;&gt;&lt;a href=&quot;#&quot; class=&quot;pricing-button&quot;&gt;Buy now&lt;/a&gt;&lt;/div&gt; &lt;/div&gt; &lt;/div&gt;</pre> <p>In the list items, the items that labeled as not supported will have class name "not-supported".</p> <p>In WHMCS template, you will be using this list code when you add the ordering list, to be looks like the Html template exactly.</p> <pre class="prettyprint"> &lt;ul&gt; &lt;li&gt;Storage &mdash; 10 GB&lt;/li&gt; &lt;li&gt;Bandwidth ( Traffic ) &mdash; 15 GB&lt;/li&gt; &lt;li&gt;Domain name &mdash; Free!&lt;/li&gt; &lt;li&gt;Ram &mdash; 128 MB&lt;/li&gt; &lt;li&gt;Subdomains &mdash; 10 GB&lt;/li&gt; &lt;li&gt;Sharing data&lt;/li&gt; &lt;li&gt;Unlimited Email Account&lt;/li&gt; &lt;li class=&quot;not-supported&quot;&gt;Support 24/7&lt;/li&gt; &lt;li class=&quot;not-supported&quot;&gt;One Click Install&lt;/li&gt; &lt;li class=&quot;not-supported&quot;&gt;Private SSL &amp; IP&lt;/li&gt; &lt;li class=&quot;not-supported&quot;&gt;Free VoIP Phone Service&lt;/li&gt; &lt;/ul&gt;</pre> <h3 id="apps">Apps Icons & text</h3> <p>To change the image logo in the apps section, replace the src="" url of the img tag with your url.</p> <p>Also the app title can be changed in the same code as follow:</p> <pre class="prettyprint"> &lt;div class=&quot;app-icon-holder app-icon-holder1 opened&quot; data-id=&quot;1&quot;&gt; &lt;div class=&quot;app-icon&quot;&gt;&lt;img src=&quot;images/wordpress.png&quot; alt=&quot;wordpress&quot;&gt;&lt;/div&gt; &lt;div class=&quot;app-title&quot;&gt;Wordpress&lt;/div&gt; &lt;/div&gt;</pre> <p>And for the details, you have to modify the following code:</p> <pre class="prettyprint"> &lt;div class=&quot;app-details1 show-details&quot;&gt; &lt;div class=&quot;app-title&quot;&gt;Wordpress Hosting&lt;/div&gt; &lt;div class=&quot;app-text&quot;&gt;Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.&lt;/div&gt; &lt;/div&gt;</pre> <p>Make sure to repeat the same modifications in this code as well.</p> <h3 id="testimonials">Testimonials</h3> <p>If you want to add a testimonial, duplicate this code and modify it with your data.</p> <pre class="prettyprint"> &lt;div&gt; &lt;div class=&quot;details-holder&quot;&gt; &lt;img class=&quot;photo&quot; src=&quot;images/person1.jpg&quot; alt=&quot;&quot;&gt; &lt;h4&gt;Chris Walker&lt;/h4&gt; &lt;h5&gt;CEO &amp; CO-Founder @HelloBrandio&lt;/h5&gt; &lt;p&gt;Lorem ipsum dolor sit amet, consectetur adipiscing elit. Mauris egestas non ante non consequat. Aenean accumsan eros vel elit tristique, non sodales nunc luctus. Etiam vitae odio eget orci finibus auctor ut eget magna.&lt;/p&gt; &lt;/div&gt; &lt;/div&gt;</pre> <h3 id="photo-slider">Photo slider</h3> <p>To change any photo slider in the template, look at the following code:</p> <pre class="prettyprint"> &lt;div class=&quot;photo-slider&quot;&gt; &lt;div&gt;&lt;img src=&quot;images/photo1.jpg&quot; alt=&quot;&quot;&gt;&lt;/div&gt; &lt;div&gt;&lt;img src=&quot;images/photo2.jpg&quot; alt=&quot;&quot;&gt;&lt;/div&gt; &lt;div&gt;&lt;img src=&quot;images/photo3.jpg&quot; alt=&quot;&quot;&gt;&lt;/div&gt; &lt;/div&gt;</pre> <p>You can add, remove or replace any photo by replacing the src="" url.</p> <h3 id="address">Footer - address & social</h3> <p>To edit the address in the footer, simply change the information in this code.</p> <pre class="prettyprint"> &lt;div class=&quot;address-holder&quot;&gt; &lt;div class=&quot;phone&quot;&gt;&lt;i class=&quot;fa fa-phone&quot;&gt;&lt;/i&gt; 00 285 900 38502&lt;/div&gt; &lt;div class=&quot;email&quot;&gt;&lt;i class=&quot;fa fa-envelope&quot;&gt;&lt;/i&gt; hello@hostino.io&lt;/div&gt; &lt;div class=&quot;address&quot;&gt; &lt;i class=&quot;fa fa-map-marker&quot;&gt;&lt;/i&gt; &lt;div&gt;Bahrain, Manama&lt;br&gt; Road 398, Block 125&lt;br&gt; The City Avenue&lt;br&gt; Office 38, floor 3&lt;/div&gt; &lt;/div&gt; &lt;/div&gt;</pre> <p>To put a url to the social media icons, replace the # with your url.</p> <pre class="prettyprint"> &lt;div class=&quot;col-xs-2&quot;&gt;&lt;a href=&quot;#&quot;&gt;&lt;i class=&quot;fa fa-facebook&quot;&gt;&lt;/i&gt;&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;col-xs-2&quot;&gt;&lt;a href=&quot;#&quot;&gt;&lt;i class=&quot;fa fa-twitter&quot;&gt;&lt;/i&gt;&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;col-xs-2&quot;&gt;&lt;a href=&quot;#&quot;&gt;&lt;i class=&quot;fa fa-youtube-play&quot;&gt;&lt;/i&gt;&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;col-xs-2&quot;&gt;&lt;a href=&quot;#&quot;&gt;&lt;i class=&quot;fa fa-behance&quot;&gt;&lt;/i&gt;&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;col-xs-2&quot;&gt;&lt;a href=&quot;#&quot;&gt;&lt;i class=&quot;fa fa-dribbble&quot;&gt;&lt;/i&gt;&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;col-xs-2&quot;&gt;&lt;a href=&quot;#&quot;&gt;&lt;i class=&quot;fa fa-pinterest-p&quot;&gt;&lt;/i&gt;&lt;/a&gt;&lt;/div&gt;</pre> <h3 id="whmcs">WHMCS Theme Installation</h3> <ul> <li>Copy "hostino" folder to WHMCS templates folder.</li> <li>Copy "hostino_cart" and "standard_cart" folders to WHMCS templates/orderforms folder.</li> <li>On your WHMCS admin panel go to Setup > General Settings, choose the template "Hostino" and save changes.</li> <li>Go to Setup > General Settings then Ordering Tab, choose "Hostino Cart" and save changes.</li> </ul> <hr> <p>Once again, thank you so much for purchasing this template. We'd be glad to help you if you have any questions relating to this template. No guarantees, but We'll do our best to assist. If you have a more general question relating to the themes on ThemeForest, you might consider visiting the forums and asking your question in the "Item Discussion" section.</p> </div> </div> </div> <div id="footer" class="container-fluid"> <div class="row"> <div class="col-xs-12"> <div class="brandio-logo-holder"> <img src="assets/images/brandio.png" alt="Brandio"> </div> <div class="doc-info"> <div><b>Created:</b> 12/3/2017</div> <div><b>By:</b> Brandio</div> <div><b>Support:</b> faisal@brandio.io</div> </div> </div> </div> </div> <a id="back-to-top" href="#header"><i class="fa fa-chevron-up" aria-hidden="true"></i></a> <script src="assets/js/jquery.min.js"></script> <script src="assets/js/bootstrap.min.js"></script> <script src="assets/js/prettify.js"></script> <script src="assets/js/main.js"></script> </body> </html>
require 'mxx_ru/cpp' MxxRu::Cpp::exe_target { required_prj "so_5/prj.rb" target "_test.bench.so_5.parallel_parent_child" cpp_source "main.cpp" }
Margaret MacAdam, Associate Professor at the University of Toronto, gives a background to integrated care in Canada, and explains how the PRISMA integrated service delivery model has helped to improve the health, empowerment, and satisfaction of frail older people in the community. The 2012 Care co-ordination conference shared practical lessons from the front line to help delegates understand how to better co-ordinate care services, and disseminated the lessons from our research on care co-ordination for people with complex chronic conditions.
User account menu Breadcrumb Kitten Rescue Activist Hannah Shaw Has Viral Social Media Following With 'Kitten Lady' Posted by Rebecca West on November 10, 2017 Hannah Shaw, the Kitten Lady (image via Kitten Lady FB) Orphaned kittens have a hero in Hannah Shaw, aka the Kitten Lady. Through her tireless efforts, Shaw, "a kitten rescuer, humane educator and unwavering animal advocate who has dedicated her life to finding innovative ways to protect animals," has amassed a viral social media following that's helping to change the way the tiniest felines are treated and viewed globally. Kitten Lady Inc. Along with her partner Andrew Marttila, the two have created an organization known as Kitten Lady Inc, which the dynamic duo also operate. It provides rescue and adoption services to orphaned kittens in the Washington DC area. Shaw has become so successful in her calling that she's been featured in such publications as People and Cosmo, she's been a guest expert on Animal Planet's My Cat from Hell, and this year she was awarded the Advocate of the Year award by CatCon Worldwide. She's a busy lady. Instagram While all of her hard work has helped to make a name for her, it's her social media presence that's facilitated her rescue efforts to go viral. Her Instagram account, @kittenlady, has attracted a whopping 529k followers, and the pictures she posts make it easy to understand why. But the account's popularity isn't just about adorable images of fluffy kittens — they are undeniably cute, though. Facebook Her social media popularity is also about the content she posts, like with her Kitten Lady Facebook page, where she has well over 200,000 followers and provides updates on global situations concerning her cause, opinion pieces that prove she's not afraid to sound off when she feels it's warranted, and information regarding feline health and adoptions. YouTube Yup, video plays a large part in getting Shaw's message out, too. That's why she started her own YouTube channel. Viewers that tune in can find fun and instructional videos covering a myriad of topics there such as how to safely feed a newborn or care for a paralyzed kitten. Kitten Lady Workshops Like all this isn't enough to keep her busy full-time, the "neonatal kitten warrior" also conducts workshops, like the one that's coming up on November 19 in New York City discussing how to save the lives of kittens, which is being held at the Meow Parlour, NYC's cat cafe. For more information about this event, or if you're interested in attending one of her other events, you can check out dates and availability at KittenLady.org/events.
Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway. Although the mechanisms of arsenic trioxide (As2O3)-induced apoptosis have been elucidated extensively in hematologic cancers, those in solid tumors have yet to be clearly defined. In the present study, we show that As2O3 triggers apoptosis through the intrinsic pathway and significantly downregulates stathmin expression. Decreased stathmin expression is necessary for the dissipation of mitochondrial membrane potential (Δ ψm), the translocation of cytochrome C from the mitochondria to the cytosol, and subsequent cell death. Overexpression of wild type stathmin effectively delays As2O3-mediated mitochondrial events. Conversely, expression of a small interfering RNA (siRNA) targeting stathmin enhances As2O3-triggered apoptosis in cell culture and in mouse models. Furthermore, we demonstrate that As2O3-induced stathmin downregulation is mediated through the phosphatidylinositol-3-kinase (PI3K) signaling pathway, and that a PI3K inhibitor effectively attenuated stathmin downregulation and cell apoptosis upon As2O3-treatment. These data support a stathmin-dependent pathway of As2O3-mediated cell death in solid tumor cells, and indicate that stathmin is a target of the PI3K/Akt pathway in cervical cancer cells. All these results may provide a rationale for improving the efficacy of As2O3 as a therapeutic agent through combination treatment with stathmin inhibition or PI3K/Akt inhibitors.
Urban Eola UE take :: Independent movies have recently been much better than the major studio movies. Some people think they are always better than major productions. The arduous, corporate, and excessively expensive process that major studios have to go through before even filming a movie is not conducive to maximum artistic and creative value. Take a tip and look up a local film festival in your area (they go on more often than you think) and attend it. You will get a much different and often times better feel than after leaving a 100 million dollar film.
/* * Copyright (C) 2011-2019 Project SkyFire <http://www.projectskyfire.org/> * Copyright (C) 2008-2019 TrinityCore <http://www.trinitycore.org/> * Copyright (C) 2006-2019 ScriptDev2 <https://github.com/scriptdev2/scriptdev2/> * * This program is free software; you can redistribute it and/or modify it * under the terms of the GNU General Public License as published by the * Free Software Foundation; either version 3 of the License, or (at your * option) any later version. * * This program is distributed in the hope that it will be useful, but WITHOUT * ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or * FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for * more details. * * You should have received a copy of the GNU General Public License along * with this program. If not, see <http://www.gnu.org/licenses/>. */ /* ScriptData SDName: Boss_Razorgore SD%Complete: 50 SDComment: Needs additional review. Phase 1 NYI (Grethok the Controller) SDCategory: Blackwing Lair EndScriptData */ #include "ScriptPCH.h" //Razorgore Phase 2 Script enum Say { SAY_EGGS_BROKEN1 = -1469022, SAY_EGGS_BROKEN2 = -1469023, SAY_EGGS_BROKEN3 = -1469024, SAY_DEATH = -1469025 }; enum Spells { SPELL_CLEAVE = 22540, SPELL_WARSTOMP = 24375, SPELL_FIREBALLVOLLEY = 22425, SPELL_CONFLAGRATION = 23023 }; class boss_razorgore : public CreatureScript { public: boss_razorgore() : CreatureScript("boss_razorgore") { } CreatureAI* GetAI(Creature* creature) const { return new boss_razorgoreAI (creature); } struct boss_razorgoreAI : public ScriptedAI { boss_razorgoreAI(Creature* creature) : ScriptedAI(creature) {} uint32 Cleave_Timer; uint32 WarStomp_Timer; uint32 FireballVolley_Timer; uint32 Conflagration_Timer; void Reset() { Cleave_Timer = 15000; //These times are probably wrong WarStomp_Timer = 35000; FireballVolley_Timer = 7000; Conflagration_Timer = 12000; } void EnterCombat(Unit* /*who*/) { DoZoneInCombat(); } void JustDied(Unit* /*Killer*/) { DoScriptText(SAY_DEATH, me); } void UpdateAI(const uint32 diff) { if (!UpdateVictim()) return; //Cleave_Timer if (Cleave_Timer <= diff) { DoCast(me->getVictim(), SPELL_CLEAVE); Cleave_Timer = urand(7000, 10000); } else Cleave_Timer -= diff; //WarStomp_Timer if (WarStomp_Timer <= diff) { DoCast(me->getVictim(), SPELL_WARSTOMP); WarStomp_Timer = urand(15000, 25000); } else WarStomp_Timer -= diff; //FireballVolley_Timer if (FireballVolley_Timer <= diff) { DoCast(me->getVictim(), SPELL_FIREBALLVOLLEY); FireballVolley_Timer = urand(12000, 15000); } else FireballVolley_Timer -= diff; //Conflagration_Timer if (Conflagration_Timer <= diff) { DoCast(me->getVictim(), SPELL_CONFLAGRATION); //We will remove this threat reduction and add an aura check. //if (DoGetThreat(me->getVictim())) //DoModifyThreatPercent(me->getVictim(), -50); Conflagration_Timer = 12000; } else Conflagration_Timer -= diff; // Aura Check. If the gamer is affected by confliguration we attack a random gamer. if (me->getVictim() && me->getVictim()->HasAura(SPELL_CONFLAGRATION)) if (Unit* target = SelectTarget(SELECT_TARGET_RANDOM, 1, 100, true)) me->TauntApply(target); DoMeleeAttackIfReady(); } }; }; void AddSC_boss_razorgore() { new boss_razorgore(); }
Marianne : Un nouvel attentat islamiste a frappé la France cette semaine. Vous qui avez fondé la Brigade des mères, une association qui combat l’islamisation des quartiers, comment aider les jeunes, et en particulier les musulmans qui seraient tentés de rejoindre la Syrie ? Nadia Remadna : Se focaliser sur les musulmans, même "les bons musulmans républicains", c’est encore coller des étiquettes. Aux musulmans comme à tous les citoyens, il faut imposer le respect de la loi, c’est tout. On ne devient pas terroriste parce qu’on n’a pas d’emploi ou parce qu’on est en dépression. Avant d’être radical, l’islamisme commence par une recherche d’identité. Selon moi, on a raté une génération avec la politique de la ville, les grands frères etc. L'urgence, c'est les petits de 10 ans... Comment les choses ont-elles évolué depuis que vous avez dénoncé, dans un livre*, la montée de l’islamisme dans votre ville, à Sevran ? Nadia Remadna : J’ai été menacée dans la rue, harcelée sur Facebook. A mon travail c’est l’enfer. Des membres de La Brigades des mères ont quitté l’association par peur de passer pour des mauvaises musulmanes. Je suis accusée d’être un danger pour ma famille, alors que je voulais la protéger. Tout ça parce que j’ai dit qu’il fallait construire des écoles plutôt que des mosquées... Et à Sevran ? Une quinzaine de Sevranais sont partis faire le djihad et ne sont pas revenus, mais la seule réaction du maire a été de dénoncer les lanceurs d'alerte, qu'il accuse de salir sa ville. Puisque Stéphane Gatignon passe pour un homme courageux, ça m'étonne qu'il n'ait pas cherché à rencontrer les mamans qui lui reprochent de dérouler le tapis rouge aux salafistes. A la place, il continue à recevoir les religieux, comme si c'étaient eux qui allaient fabriquer son vivre-ensemble. (...) Ici, le religieux fait les CV, t'amène en vacances, paye ta dette de loyer avec des cotisations, à condition que tu sois de la bonne religion. C'est le contraire du vivre-ensemble. Ca alimente la victimisation et la haine. (...) *Comment j'ai sauvé mes enfants, Nadia Remadna avec Daniel Bernard, grand reporter à Marianne (éd. Calmann-Lévy, 2016), 254 p. >>> Retrouvez l'intégralité de cet entretien dans le numéro de Marianne en kiosques.
682 F.2d 204 82-2 USTC P 9471 RECORD WIDE DISTRIBUTORS, INC., Appellant,v.COMMISSIONER OF INTERNAL REVENUE, Appellee. No. 81-1853. United States Court of Appeals,Eighth Circuit. Submitted March 10, 1982.Decided July 14, 1982. Claude Hanks, Leonard R. Yocum, Creve Coeur, Mo., for appellant. Glenn L. Archer, Jr., Asst. Atty. Gen., Michael L. Paup, Daniel F. Ross, Michael J. Roach, Attys., Tax Div., Dept. of Justice, Washington, D. C., for appellee. Before HEANEY, BRIGHT and HENLEY,* Circuit Judges. HENLEY, Senior Circuit Judge. 1 Taxpayer Record Wide Distributors, Inc. appeals the decision of the tax court upholding the Commissioner's assessment of certain deficiencies for the tax years 1972, 1973 and 1974. We affirm. 2 Taxpayer, a Missouri corporation, is a wholesale distributor of records and tapes, and deals primarily in "cut-outs," budget merchandise that the manufacturer is unable to sell at market price. Because cut-outs have limited marketability, taxpayer's normal business practice is to send an invoice with each shipment to its customers, but to defer immediate payment in order to allow its customers to return any unsold items, generally fifty to sixty per cent, along with payment for the items sold.1 3 The issues in this case concern taxpayer's method of accounting during the tax years in question. Characterizing this method as a hybrid of cash and accrual methods, the tax court found that Record Wide reduced its inventory when items were shipped to its customers, but recorded sales upon actual receipt of payment.2 The Commissioner concluded that this hybrid method did not clearly reflect taxpayer's income,3 see 26 U.S.C. § 446(b), and recalculated tax liability for the years 1972, 1973 and 1974, on an accrual basis, resulting in the assessment of deficiencies in the amounts of $92,056.99, $34,444.54 and $21,232.29, respectively.4 4 Record Wide defends its accounting method as consistent with its unique business practices. It is established, however, that the Commissioner has broad discretion to evaluate and modify a taxpayer's accounting method in order to insure the clear reflection of income, and that the taxpayer has the heavy burden of proving that the Commissioner's determination is plainly arbitrary. Thor Power Tool Co. v. Comm'r, 439 U.S. 522, 532-33, 99 S.Ct. 773, 780-81, 58 L.Ed.2d 785 (1979); Clement v. United States, 580 F.2d 422, 430 (Ct.Cl.1978), cert. denied, 440 U.S. 907, 99 S.Ct. 1214, 59 L.Ed.2d 455 (1979). The regulations clearly mandate the use of an accrual accounting method for businesses that maintain inventories, unless the Commissioner, in his discretion, authorizes an alternate method. Treas. Reg. § 1.1446-1(c)(2). The tax court concluded, and we agree, that Record Wide failed to establish that the Commissioner abused his discretion by requiring the use of an accrual method to compute Record Wide's tax liability. 5 Taxpayer's next contention is that even if an accrual method is used, income should not be reported until actual payment is received because until that time the right to receive income in an amount determinable with reasonable accuracy is not established due to the unpredictable percentage of returns. We think that Record Wide has possibly confused the uncertainty of the time and amount of actual payment with the right to receive payment. The tax court found that Record Wide dealt with its customers on a "sale or return" basis, and that the right to receive payment thus arose upon delivery of the merchandise to taxpayer's customers. As indicated, taxpayer reduced its inventory when the goods were shipped, thereby increasing cost of sales; yet taxpayer failed to show that title was retained while the goods were in the possession of its customers. Moreover, as the tax court noted, even if Record Wide dealt on a consignment basis, income would be recorded upon the sale of the goods rather than upon receipt of payment. 6 We agree with the tax court that, on the basis of an accrual accounting method, the invoice amounts were properly included in income as accounts receivable upon delivery of the merchandise and the corresponding reduction of inventory. 7 The final issue is whether Record Wide is entitled to a bad debt deduction or a deduction for an addition to a bad debt reserve for 1974. See 26 U.S.C. § 166. In that year, Sound On Tape Distributors, Inc., one of taxpayer's major customers, suffered a serious financial setback and was unable to pay Record Wide the $176,574.22 remaining after all returns were credited. Because income was reported on a cash received basis, Sound On's failure to pay was not charged off by taxpayer in 1974. Taxpayer now contends that if its 1974 tax liability is recomputed on an accrual basis, it is entitled to a deduction under § 166(a)(1) or (2), or (c).5 8 Relying on the facts that Sound On attempted to salvage its business for several years and that taxpayer continued to deal with Sound On, albeit not on a credit basis, the tax court concluded, and we agree, that taxpayer has failed to prove that the debt was wholly worthless in 1974, as required by § 166(a) (1). See Riss v. Comm'r, 478 F.2d 1160, 1165-66 (8th Cir. 1973). With respect to § 166(a)(2), and (c), we recognize, as did the tax court, that the Commissioner is vested with broad discretion to allow a deduction for a partially worthless debt, Brimberry v. Comm'r, 588 F.2d 975, 977 (5th Cir. 1979), or for an addition to a bad debt reserve, Thor Power Tool v. Comm'r, 439 U.S. at 547-48, 99 S.Ct. at 788-89; Malone & Hyde, Inc. v. United States, 568 F.2d 474, 477 (6th Cir. 1978). Although the Commissioner might have reached a different result, we cannot say that he clearly erred in finding that Record Wide failed to show that the partial worthlessness could have been predicted in 1974 with reasonable certainty. See Sika Chemical Corp. v. Comm'r, 64 T.C. 856, 863 (1975). We conclude that the Commissioner did not abuse his discretion in disallowing a bad debt deduction or a deduction for an addition to a bad debt reserve in 1974.6 9 Finding no reversible error, the decision of the tax court, largely for reasons stated by that court, is affirmed. * The Honorable J. Smith Henley assumed senior status on June 1, 1982 1 The tax court noted that Record Wide encouraged returns and payments within 120 days of shipment, but often did not receive returns and payments within 120 days and sometimes settlement of accounts extended more than a year from date of sale 2 Taxpayer asserts that it used a cash accounting method, but the tax court observed that the evidence supported a finding that taxpayer actually used an accrual method since an accounts receivable ledger was maintained with a separate entry for each customer. However, for purposes of its opinion, the court assumed that taxpayer used a hybrid system 3 This conclusion is based, at least in part, on the fact that thirty to thirty-five per cent of returns and payments occurred in the tax year following shipment 4 These figures have since been reduced by certain concessions 5 Section 166 provides in pertinent part: (a)(1) Wholly worthless debts.-There shall be allowed as a deduction any debt which becomes worthless within the taxable year. (2) Partially worthless debts.-When satisfied that a debt is recoverable only in part, the Secretary may allow such debt, in an amount not in excess of the part charged off within the taxable year, as a deduction. (c) Reserve for bad debts.-In lieu of any deduction under subsection (a), there shall be allowed (in the discretion of the Secretary) a deduction for a reasonable addition to a reserve for bad debts. 6 The tax court noted that taxpayer charged the debt off its books in 1978 but did not take a tax deduction. The record does not indicate whether Record Wide has attempted to adjust its tax liability to reflect deduction for this loss in any other year or the extent to which 1978 or other years might still be open for such adjustment. Nor does the record reflect that taxpayer had established and used a bad debt reserve for any of the years at issue
// Copyright 2016 Unknwon // // Licensed under the Apache License, Version 2.0 (the "License"): you may // not use this file except in compliance with the License. You may obtain // a copy of the License at // // http://www.apache.org/licenses/LICENSE-2.0 // // Unless required by applicable law or agreed to in writing, software // distributed under the License is distributed on an "AS IS" BASIS, WITHOUT // WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the // License for the specific language governing permissions and limitations // under the License. package ini import ( "fmt" ) type ErrDelimiterNotFound struct { Line string } func IsErrDelimiterNotFound(err error) bool { _, ok := err.(ErrDelimiterNotFound) return ok } func (err ErrDelimiterNotFound) Error() string { return fmt.Sprintf("key-value delimiter not found: %s", err.Line) }
Welcome to AElf's official documentation. This GitBook is where we centralize our guides, documents and api references. Wether you're a dApp developer looking to build some awesome apps on top of AElf or simply just interested in seeing what a running node looks like, this place is for you! As of today the documentation is correct but still a work in progress so we invite you to frequently visit and discover any new content. #### A bit more about AElf AElf's main objective is to permit scalability and extensibility through a multi-layer branching structure formed by a main chain and multiple levels of side-chains (a tree like structure). Each side-chain will be designed for one business use case. AElf also aims to make it as easy as possible to extend/customize the system by providing easy to use tools and frameworks in order to customize the chains and write smart contracts. AElf will support various languages that will let developers choose the one they are the most comfortable with. AElf will improve overall blockchain performance by executing transactions in parallel and isolating smart contracts in their own side-chains in order to segregate the systems resources. ## This GitBook This GitBook contains various different types of documentation and depending on what you will use AElf for, you should navigate to different sections. Here are a few links you can follow to get you started. #### Guides and tutorials - [**Getting started**](tutorials/setup/setup.md) - setting up dependencies and running a node. - [**Smart contract development**](tutorials/developing-smart-contracts/first-contract.md) - developing smart contract for AElf. #### AElf concepts - [**protocol**](protocol/main.md) - some articles about blockchain related concepts and how they are used and implemented in AElf. - [**smart contract**](contract/main.md) - a more advanced section with more in-depth explanations of AElf smart contracts. - [**cross chain**](crosschain/main.md) - information about how AElf implements side chains. - [**public chain ecosystem**](public-chain/main.md) - information related to AElf's public blockchain and ecosystem. - [**architecture**](architecture/main.md) - this section is for **advanced** users, it explains the architectural concepts behind the node's design. #### References This section provides links to API references for the Command Line Interface, the js-sdk and the nodes RPC interface. - [**command line**](resources/cli/introduction.md) - a reference for the available commands on AElf's CLI. - [**web api**](web-api-reference/reference.md) - a reference for the available methods on AElf's web api. - [**js sdk**](sdk/javascript/js-sdk.md) - a reference for the available APIs in the js SDK. ## Some resources - [**contract APIs**](resources/smart-contract-apis/index.md) - API explanation for certain important smart contracts. You can find the original whitepaper [here](https://aelf.io/gridcn/aelf_whitepaper_EN.pdf?v=1.6). It will give you a more thorough explanation on the concepts that drive AElf and its development. Of course, there's the official GitHub [here](https://github.com/AElfProject/AElf) and the js-sdk repo [here](https://github.com/AElfProject/aelf-sdk.js).
<?php namespace App\Entity; use App\TraitAlreadyHere; class User { use TraitAlreadyHere; }
I've been lusting after a Chicago Cutlery folding kitchen knife. Problem is, they don't make 'em anymore and they are going for $60 or better on ebay. Does anybody know of another folding kitchen knife that would be less, or have you found a good substitute? I'm most interested in something that folds because it will prevent cutting myself in the dark and needs less room for storage. I tried just using a big pocket knife, but blade length is a bit short. Stewart, I have been using a Santoku knife for camping for several years now. Of course it doesn't fold and it is big and sharp so I built a sheath for it to protect both me and the blade. Unless you are backpacking this thing is sweet! It is sharp enough for the usual peeling and slicing duties around camp and heavy enough to be used as a light cleaver. And long enough that it can do much more than a lesser blade. In addition it is wide enough that you can scoop up stuff that you have already sliced and diced. The only thing it doesn't seem to do is slice bread but I have a nice Victornox bread knife for that. Take a look at the Santoku and see if it would work for your camping. If not it is still a great addition to your kitchen. I looked at Santoku knives on Amazon. The first one I saw was over $100, then I saw some $10 ones... and they had sheaths. The colored ones are weird, but it's really not that bad. Might be a good idea, and at price that won't make me feel like I'm wasting money. I just won't get as much use out of it, or appreciate it enough to want to pony up for a better one. I'd love to eat a meal that either of you guys made in camp, but I don't think you'd feel the same way about my meals. I'm not much of a camping cooker, but a decent all-purpose cooking knife is missing from my gear. Thanks for the input I can't imagine a genuine Santoku for $10 on Amazon. I'd be very skeptical. One thing I'd do is closely check out the many knives in thrift stores. My brother found a Henckle bread knife thrown into a box at a thrift store. He bought it for $5. It would retail for ~$130. If a non folding knife would work the Victornox series of kitchen cutlery are an exceptionally good value and out perform knives costing many times more. Readily available and exceptionally functional. Spend the $100 and get yourself a old Sabatier carbon steel 10" off eBay or a quality cutlery shop (good knife shops aren't found in malls, just so you know). They look ugly as hell, but they will take an edge that you can shave with. Well, when it comes to price, you just have to look at the quality. Santoku is a style, not a brand (at least I thought so). I have a couple nicer Santoku knives that I love to death (and weren't cheap, even getting them at "cost"). I agree, thrift shops are fantastic! Especially if you get into ones in nicer neighborhoods. Know people that want to toss out a knife if it's dull. Quick hit on the stone and it's nice and sharp again. But agree, if you find one "cheap" on Amazon, chances are it's just that, CHEAP! Picked up a "Chinese" knife in china town a few years back. Its basically a small cleaver. about 9 inches by 4 inches. Keeps a tight edge and can slice chop, hack like a cleaver and double as a spatula. The Mrs and kids don't like it 'cause its too big, so they don't jack it up. My "go to" knife's a small Chinese cleaver from the Wok Shop in SF. Carbon steel and sharp as a scalpel. Easy to handle, easy to maintain, great for slicing & dicing, but it won't work as a fillet knife.
Thursday, February 16, 2012 With the natural lighting of the skylight along with the light that comes through the window in the door, and the two little night lamps on the wall, this space would make a beautiful art gallery. The wall space is huge, and I could fill in all of that white space with original artwork and prints. I can collect artwork from Deviant Art, Etsy, and from my own work, and I can find frames at dollar stores and thrift shops. It would be a great conversation piece at get-togethers, and it would feel so nice, inspiring, and fresh to walk down the art covered hallway. Hubby and I have lived in this house for 6 months, and drab blank walls are no longer acceptable. I can't wait to get started. I'll definitely post pictures as I start to add art to the walls. Do you have a gallery in your house? I'd love to see a picture of it. Please feel free to post links to your pictures in the comments. Monday, February 6, 2012 So delicious the inlaws said it tasted just like their recipe. I cruised the internet looking for a simple peanut butter cookie recipe that did not contain dairy, and after some tweaking I finally found one that my picky hubby will eat! Preheat oven to 350 degrees. Mix ingredients in bowl until well blended. (Due to the nature of the ingredients it's best to refrigerate the dough until it's cool. Otherwise the dough is too sticky to roll into a ball so you can make drop cookies instead, which is what I did.) Place (and flatten) your balls or dropped dough blobs onto a baking sheet. Bake for approximately 10 minutes until golden brown. These cookies are so moist they need a moment to cool on the sheet or they will break apart. Even after they cool they do tend to break a little, so if I find a solution I'll be sure to update this. I'm thinking more flax seed. Some random tidbits of info: * 1/3 cup applesauce is a great substitute for 1 egg.* consume ground flax seed otherwise you don't get the same nutrients* the cookies will taste the best if you use a very simple peanut butter. The one I used has the ingredients listed as: organic peanuts, organic palm oil, natural cane sugar, and sea salt.* use parchment paper for easy removal of baked goods and super easy clean up Sunday, February 5, 2012 After some technical difficulties and an endless amount of mind-changing, I'm excited to say that my new website http://www.1337art.com is open for business! As I continue to add inventory to the site you will have the option to pick and choose which color and size options you want without having to wade through a lot of similar listings, as it currently is in my Etsy shop. You can also purchase an item without having to register for an account with the option of paying via PayPal or Google Checkout! For my blog readers please use the coupon below to get Free Shipping at http://www.1337art.com this includes my International readers too. freeship12 I can't wait to get back into my studio to make many more (and new!) designs. I am currently taking custom orders in case you want to get a personalized/custom piece of jewelry for yourself or a loved one. Click here for more info. Wednesday, January 18, 2012 It's not easy to find a venue to sell your handcrafted items, your craft supplies, or your vintage finds. Sometimes a major venue like Etsy.com or Artfire.com can make major changes that will effect your business negatively. Some people feel that there are no alternatives out there for selling their items other than Etsy, Artfire, or even Ebay. But there are two sites out there that are slowly gaining momentum, and they both offer great tools to help you succeed with your business. The first alternative is Zibbet.com. It is Australia based, however, anyone in the world can set up shop. They currently have a free basic account where you can list up to 50 items for free, and they also have a month-to-month premium account as well as a yearly premium account. Currently their monthly price is $9.95 and their yearly price is $79.00. At the time of this post they are offering a free 45 day premium trial using code 45FREE, and it expires in 3 days. I opened my Zibbet Shop in 2009, and to date I have sold 2 items. They do not have much internal traffic, and their site can be slow. But their admin is quick to answer questions, and there are a lot of great items for sale. The listing process is easy, and you can import your Artfire and/or Etsy shop items into your Zibbet shop using their free importer. The other alternative is Craft is Art. It's a fairly new marketplace that accepts supplies, vintage items, and handmade items. They offer you the option to accept payments via Google Checkout, Amazon Payments, Authorize.net, PayPal, and Checks/Money Orders. They have a basic pay as you go account as well as a premium monthly or yearly account. Premium accounts can offer multiple quantities, variances (colors, sizes, etc.), and so much more. You can either pay a monthly fee of $8.99 or you can pay for a year for only $79.99. You can also import your Etsy and/or Artfire shop items into your Craft is Art shop as well as your feedback score if you choose to. They also offer you the opportunity to have a free for life account if you refer 5 people to open a premium shop. I need only two more people to use my referral codes, and my shop there will be free! If you plan to go premium there (either monthly or yearly) please use one of my referral codes: 7H5C6 85FUY To check out their full list of options and tools follow the link below: Craft is Art is very quick to submit your products to Google, and you can set up your Google Analytics account so you can track your traffic. I've sold 3 items there to date in my shop, and I get a lot of internal traffic as well as traffic from search engines. I only have 17 items for sale there at the moment, but I have very high hopes that my business will be successful on this venue. Etsy and Artfire succeed through their sellers, but if their sellers leave to other venues, these new venues can succeed too. It's the beginning of the year and now is a great time to think long and hard about your business, and what you believe will help you succeed. Saturday, January 7, 2012 Or she acts like she was a dog in another life. I bought her a pack of plastic coil toys, and she loves them so much that she actually fetches them and brings them back to me like a dog. Katniss's favorite color appears to be blue, because that's the toy she plays with the most. If I pick up the blue toy I have her immediate attention, and when I throw it across the room she runs, picks it up in her mouth, and runs back over to me. Of course I have to take it and throw it again because it's just so darn cute. Sometimes she gets smart and when she comes back over she lays on the toy so I can't get to it. Sometimes I throw it to a tough place, and she can't reach it so she will circle the area and cry until she can find it. I bought these toys from Vitacost. My husband didn't believe the cats would even play with them. Friday, January 6, 2012 An amazing cake decorator. I suppose it's doable now, but I've missed so many years of practice. One year for my mom's birthday I decided to make her a three layer cake. Unfortunately somehow it fell in on itself, and it was so odd my brother that eats everything didn't even want it. One year for my anniversary I made my husband some cookies with monkey and dragon shaped cookie cutters. Somehow they didn't hold their shape so he had to go by my word that they were in fact the monkeys and dragons...only blobs. Apparently baking is just not my thing, but I still enjoy the attempt. I think the closest I will get to be an amazing cake decorator is the fun of making shaped baked goods for my husband's birthday and future kids' birthdays. I think I'll stick to the beads. :] The picture is a dog cake from Albertson's that I bought for my mom's birthday last year.
Matt Every Matthew King Every (born December 4, 1983) is an American professional golfer who has won on both the PGA Tour and Nationwide Tour. Early years Every was born in Daytona Beach, Florida. He attended Mainland High School in Daytona Beach, where he played for the Mainland Buccaneers men's golf team. He was recognized as the Volusia County Golfer of the Year for four consecutive years, and was an all-state selection after his junior and senior seasons. Amateur career Every accepted an athletic scholarship to attend the University of Florida in Gainesville, Florida, where he played for coach Buddy Alexander's Florida Gators men's golf team in National Collegiate Athletic Association (NCAA) competition from 2003 to 2006. During his career as a Gator golfer, he was a three-time first-team All-Southeastern Conference (SEC) selection (2004, 2005, 2006), and a four-time All-American (2003, 2004, 2005, 2006). As an amateur, he played in the 2005 U.S. Open at Pinehurst in North Carolina and finished in a tie for 28th place. He was the recipient of the Ben Hogan Award, recognizing the best college golfer in the United States in 2006. Professional career Every turned professional after completing his NCAA eligibility in 2006. Before he found success on any major golf tour after turning professional, he competed on The Golf Channel's original series The Big Break, in Mesquite, Nevada. Every played in a select few PGA Tour and Nationwide Tour events between 2006 and 2007. Then at Q-School in December 2007, he missed a place on the PGA Tour by just two strokes, but was rewarded with a place on the Nationwide Tour in 2008. In his second start in 2008, he finished runner-up in the Mexico Open. He finished the season with four top-10 finishes and made $180,000 in earnings, just outside the top 25 in earnings. In his 2009 sophomore year on the Nationwide Tour, Every was ranked forty-ninth on the money list going into the Nationwide Tour Championship, needing a third-place finish or better to obtain his PGA Tour card for 2010. He had made fifteen of twenty-five cuts and had three top-10 finishes entering the season's final event. He shot a second-round 63 to take the 36-hole lead, a lead he did not relinquish. He won the event by three shots over Nationwide Tour money leader Michael Sim. The win vaulted him to tenth on the money list, and qualifying him as a PGA Tour rookie for 2010. However, in 2010 Every finished 140th and dropped back to the Nationwide Tour for 2011. He finished 2011 in 18th place and returned to the PGA Tour, where he has remained through 2015. Every was one of three men arrested in a hotel in Bettendorf, Iowa and charged with possession of marijuana on July 6, 2010. In a statement, he denied possessing the drug but apologized for poor judgment. He was subsequently suspended for 90 days from the Tour. Every earned his first PGA Tour win at the 2014 Arnold Palmer Invitational and would earn his first Masters invitation. He would go on to defend his title at the 2015 event. On October 18, 2019, it was announced that Every had been suspended by the PGA Tour for three months for violating its conduct policy for drugs of abuse. Personal Every is a fan of the British group Oasis. He named his son after Liam Gallagher and has a tattoo on his right bicep with "Live Forever," which is the title of an Oasis song. His daughter Quinn Palmer is named after the site of his first PGA Tour win. Professional wins (3) PGA Tour wins (2) Nationwide Tour wins (1) Results in major championships CUT = missed the half-way cut "T" = tied for place U.S. national team appearances Amateur Palmer Cup: 2004, 2005 (winners) Walker Cup: 2005 (winners) See also 2009 Nationwide Tour graduates 2011 Nationwide Tour graduates List of Florida Gators men's golfers on the PGA Tour References External links Category:American male golfers Category:Florida Gators men's golfers Category:PGA Tour golfers Category:Korn Ferry Tour graduates Category:Golfers from Florida Category:Mainland High School alumni Category:Sportspeople from Daytona Beach, Florida Category:People from Jacksonville Beach, Florida Category:1983 births Category:Living people
Winlock Washington Land For Sale No Land In Your Search Location There are no results matching your land search location. Here are some listings nearby. Premium Certified Organic Medicinal Herb Farm on a 54 acre estate with a luxury home. Goldenseal, Ginkgo and Ginseng. Full production facility on site with the state of the art washing & drying facility which is totally compliant with the FDA and related regulations. Approximately $800K of certified organic crop in the ground currently and the... The Mineral Lake Timberlands are located in Lewis County, Washington, and total 1,029.59 gross acres. The property is being offered for sale individually, or both the McKenna and Mineral Lake tracts can be acquired together. The Mineral Lake tract is a contiguous 1,029 acre block of timberland located just north of the town of Mineral, Washington... The McKenna Timberlands are located in Lewis and Pierce Counties, Washington and total 417.44 gross acres. The property is being offered for sale individually, or can be combined with the Mineral Lake offering as a single acquisition. McKenna is comprised of three separate tracts consisting of the 42.49 acre Lacamas Creek tract located in Lewis... Rocky Prairie 40 is a beautiful, 40-acre lot outside of the quiet town of Tenino. It hosts a private and tranquil setting amongst the trees. Zoned Rrr1/5 there is potential for sub-division subject to county standards, buyer to do their own due diligence. Per owner, there is an access easement from 143rd Ave SE to the property via gravel road.... Build your dream home on this 2.17 acres with spectacular views of Mt. Saint Helens, Mt. Rainier and Lake Mayfield. Once you walk this property you won't want to leave. Water, sewer, and power are at the front of the
Sam Houston State moved up to No. 2 in the final Sports Network NCAA Division I Football Championship Subdivision rankings for 2012. The Bearkats stood No. 5 in the final regular season poll in December. Sam Houston defeated all three of the Big Sky Conference's tri-champions (Cal Poly, Montana State and Eastern Washington) to reach the NCAA Division I Championship Finals in Frisco for the second year in a row. The No. 2 rankings both in 2011 and 2012 stand as Sam Houston State's highest final national poll standings in program history. The team's previous high was No. 3 in 2004. National champion North Dakota State was the Sports Network's No. 1 team. The Bison, the Missouri Valley Football Conference champions, were ranked No. 1 in 11 of the 14 polls this season. Sam Houston State (11-4) was voted second on 128 of the 142 ballots. Coach Willie Fritz's Bearkats, the Southland Conference co-champions, finished behind North Dakota State in the point total, 3,550 to 3,386. The first teams outside the Top 25 were Eastern Illinois, the Ohio Valley Conference champion, and Indiana State, which handed North Dakota State its only loss of the season, 17-14 on Oct. 13. The CAA finished with the most teams in the Top 25 with six, followed by the Big Sky with four and the Missouri Valley and SoCon with three each. There were two teams each from the Southland, Big South and Patriot League, and one each from the MEC, NEC and Ohio Valley Conference. A national panel of sports information and media relations directors, broadcasters, writers and other dignitaries selected the Top 25 throughout the season. A first-place vote was worth 25 points, a second-place vote 24 points, all the way down to one point for a 25th-place vote.
Should You Refinance Your Student Loan With a Private Lender? The cost of higher education creeps up from year-to-year, with each graduating class owing slightly more than the class before. This type of debt haunts graduates for decades and significantly impacts their financial choices. An American Student Assistance survey explored the impact of student debt on everyday life. According to the survey, about 27 percent of respondents found it difficult to buy daily necessities because of their student loans; 73 percent said they had put off saving for retirement; and 75 percent indicated that student loan debt affected their decision or ability to purchase a home. A third of respondents in an MyBankTracker poll reported they’d be willing to give up a body part to become free of debt. Student loan debt doesn’t just impact their daily life, but can impact graduates’ futures as well. Monica Harvin, Contributing Editor of GoodCall talks about how these loans can impact retirement: “Graduates with high interest loans won’t only be paying more for student loans. A recent GoodCall study reveals that having just $12,000 in student loans at a high interest rate can mean more than $75,000 in lost retirement savings over time. What’s more, graduates with higher than average student debt loads may be tempted to extend repayment terms rather than cope with student loan debt in the short run; however, extending repayment to 20 or 25 years can mean hundreds of thousands of dollars in lost retirement savings for a graduate with $50,000 in student loans, the study finds.” Because of the long-term implications of student loan debt, it goes without saying that many graduates look for ways to make their payments more manageable. Getting a lower payment typically starts with a lower interest rate. Since federal loans—which are funded by the government— all have the same rate, some graduates consider refinancing their loans with a private lender (bank, credit union, other type of lender) to take advantage of a lower interest rate. What is student loan refinancing? Refinancing with a private lender involves taking on a new loan with new terms, and then using these funds to pay off an existing loan. It’s important to note that refinancing is not the same as a consolidation. Consolidation and refinancing can both simplify student loan repayment, but consolidation only works with federal student loans. You can apply for a Direct Consolidation Loan and combine multiple federal loans into a single loan with one interest rate and payment. Unfortunately, this doesn’t work with private loans. If you have a combination of federal and private student loans, refinancing is the only way to merge these loans into a single loan. Refinancing is an attractive option if you don’t want the hassle of managing multiple loans and different due dates every month. But refinancing with a private lender has its risks. What you need to know about refinancing? There are significant differences between a federal and a private student loan, primarily with regard to repayment options. Refinancing federal student loans with a private lender can be a smart move for some borrowers, particularly those seeking a lower rate. “Borrowers will lose access to income-driven repayment options like Pay As You Earn and Income-Based Repayment, as well as federal student loan deferment and forbearance. These repayment options (with the exception of being able to pause payments in some cases) simply don’t exist with virtually all private lenders.” Borrowers should keep this in mind before refinancing with a private lender. Federal loans come with hardship provisions not offered by most private lenders. If you lose your job or can’t work due to an illness or injury, a federal lender will work with you and offer assistance—some private lenders aren’t as forgiving. “Based on my experience, private lenders are much more aggressive with student loan collections and more litigious — meaning they are more likely to sue the borrowers,” says Leslie Tayne, a financial attorney, debt expert and author of Life & Debt. The upside, however, is that refinancing with a private lender means that your student debt may be eligible for bankruptcy discharge, unlike federal student loans which are not dischargeable in bankruptcy. It’s also important to note that while refinancing with a private lender can result in a lower interest rate and a lower payment, this is subject to credit approval. “Before refinancing with a private lender, you should make sure you do not have any blemishes on your credit reports (i.e. missed loan payment in the past) so that you can be sure to get the best rates and terms for repayment,” says Tayne. “The new interest rate typically depends on one’s credit score, income and overall debt, among other factors.” Should you refinance your student loans? Just because private loans don’t offer the same level of protection as federal loans doesn’t mean you shouldn’t consider this option. It’s all a matter of what you consider more important, whether it’s a lower interest rate and payment, or income-driven repayment options. Before you make a decision, get a quote from a private lender and compare the new loan terms with your existing loan terms to see if the savings is worth losing your federal protection. “If borrowers feel comfortable that they will be able to make their student loan payments on time and don’t plan to use federal student loan repayment options,” says Josuweit, “refinancing can be a smart financial choice that can save thousands of dollars over the lifetime of their loans.” Valencia Higuera is based in Virginia and she covers budgeting, credit cards, and student loan debt, with expertise in frugal living, general banking, and mortgages. She is a self-proclaimed personal finance junkie. Valencia has contributed to publications and outlets including MSN, The Huffington Post, CBS News, Investopedia, and more. Ask a Question Advertiser Disclosure: Many of the savings offers appearing on this site are from advertisers from which this website receives compensation for being listed here. This compensation may impact how and where products appear on this site (including, for example, the order in which they appear). These offers do not represent all deposit accounts available. Editorial Disclosure: This content is not provided or commissioned by the bank advertiser. Opinions expressed here are author’s alone, not those of the bank advertiser, and have not been reviewed, approved or otherwise endorsed by the bank advertiser. This site may be compensated through the bank advertiser Affiliate Program. User Generated Content Disclosure: These responses are not provided or commissioned by the bank advertiser. Responses have not been reviewed, approved or otherwise endorsed by the bank advertiser. It is not the bank advertiser's responsibility to ensure all posts and/or questions are answered. Advertiser Disclosure: Many of the savings offers and credit cards appearing on this site are from advertisers from which this website receives compensation for being listed here. This compensation may impact how and where products appear on this site (including, for example, the order in which they appear). These offers do not represent all deposit accounts and credit cards available. Credit score ranges are provided as guidelines only and approval is not guaranteed.
Q: get table size from named database Using Postgres I know how to select the size of a database -> SELECT pg_size_pretty(pg_database_size('b2049623_data')); I know how to select the size of a table SELECT pg_size_pretty(pg_table_size('image_table')); but multiple databases in my postgres will a table named 'image_table' how do I specify that I want the tableSize of image_table from a particular datbase? UPDATE SELECT pg_size_pretty(pg_table_size('image_table')); returns 1688kb but the table size is 8192 bytes and the toast table size is 1656...where is the difference coming from? A: pg_table_size returns the size of the database you're currently connected to. You cannot connect to one database and query the size of a table in a different database, even if it resides on the same server.
The jasmonate pathway: the ligand, the receptor and the core signalling module. Jasmonates regulate specific developmental processes and plant adaptation to environment by controlling responses to external biotic or abiotic stimuli. The core events of jasmonate signalling are now defined. After hormone perception by SCF(COI1), JAZ (JAsmonate ZIM domain) repressors are targeted for proteasome degradation, releasing MYC2 and de-repressing transcriptional activation. JAZs are homomeric and heteromeric proteins and have been instrumental in recent advances in the field, such as the identification of COI1 as a critical component of the jasmonate receptor and the discovery of the bioactive jasmonate in Arabidopsis, (+)-7-iso-JA-Ile. Small changes in jasmonate structure result in hormone inactivation and might be the key to switching-off signalling for specific responses to stimulus and for long-distance signalling events.
UEFA Champions League 2006–2007 UEFA Champions League 2006–2007 is the official video game of the 2006–07 season of the UEFA Champions League. Developed by EA Canada, it is published by Electronic Arts worldwide under the EA Sports label. It was released on 20 March 2007 in North America, 22 March in Australia, and 23 March in Europe. This was the last game by EA Sports to include the Champions League until FIFA 19 over eleven years later. Konami held the Champions League license in the interim, with the competition featuring in all its Pro Evolution Soccer games from Pro Evolution Soccer 2009 to Pro Evolution Soccer 2018. Overview UEFA Champions League 2006–2007 was developed with the same engine used in FIFA 07, with slight graphical and gameplay adjustments, as well as the option to play a new manager mode named The Treble. The in-game commentators are Clive Tyldesley and Andy Townsend. Ultimate Team was introduced for the first time on the Xbox 360 version. References External links Interview with Matt Holme, UEFA Champions League 06-07 Producer UEFA Champions League Sizzle Category:2006–07 UEFA Champions League Category:2007 video games Category:EA Sports games Category:Esports games Category:Association football video games Category:PlayStation 2 games Category:PlayStation Portable games Category:Video games developed in Canada Category:Windows games Category:Xbox 360 games Category:Multiplayer and single-player video games
Editing video is routine in TV news reporting, but former President Bill Clinton’s comment that Hillary Clinton “frequently” fainted over the years was also cut from the written record of his interview with CBS News host Charlie Rose. Read more First discovered by the Daily Caller, what Bill Clinton told CBS News on Monday wasn’t quite the same message many viewers watched later on Monday and Tuesday when video clips were being recycled on air. Clinton was being asked about his wife, Democratic presidential nominee Hillary Clinton, and the fall she took on Sunday in New York following a September 11 remembrance event. The campaign had chalked her fainting up to “dehydration,” a claim Bill Clinton repeated to Charlie Rose. Rose then pushed Clinton, raising the concern that there may be a deeper health issue in play than simple dehydration. “Well if it is, it’s a mystery to me and all of her doctors,” Clinton told Rose. What Clinton said next has been partially edited out of CBS News transcripts and subsequent interview replays, according to The Hill. “Frequently – well, not frequently – rarely ... on more than one occasion, over the last many, many years, the same sort of thing’s happened to her when she got severely dehydrated, and she’s worked like a demon, as you know, as Secretary of State, as a senator and in the year since." Those first few words, “frequently, well, not frequently,” are the ones missing from both written transcripts and television broadcasts. While the latter could be explained as an interest in keeping good time, the three seconds it takes Clinton to speak those words should not be an issue in maintaining an accurate written record. The whole interview is set to air Tuesday night on the CBS Evening News, but the official transcript still shows Clinton’s response omitting the “frequently” comment, to say, “Well, if it is then it’s a mystery to me and all of her doctors. Rarely, on more than one occasion, over the last many, many years, the same sort of thing’s happened to her when she got severely dehydrated, and she’s worked like a demon, as you know, as secretary of State, as a senator and in the year since.” The Hill noted that “oddly,” a more complete version of the clip aired on the CBS This Morning program, including Clinton's use of "frequently."
Q: What makes creme brulee set? I've attempted to make creme brûlée several times using different recipes. The usually result is that the custard doesn't set, and gets up too runny. I've tried adjusting the ingredients, and the amount of time I let the finished product set in the fridge. I'm wondering what is the cooking process or ingredient that determines the consistency? Time in the oven, level or water in the around the ramekins in the oven, amount of creme/milk compared to egg yoke? A: I would prefer to give an answer that doesn't involve spending hundreds of dollars, but Modernist Cuisine has a great table about the consistency of custards comparing cooking temperature to egg concentration. If you can find a copy at your local library the kitchen guide has a table on page 233, otherwise check out volume 4 page 84. Quick synopsis: What sets the creme brulee is the egg proteins coagulating. If you were to take the weight of the liquid in the brulee and add 30% of that weight as eggs and cook it to 181 degrees F you would have a creme brulee texture. Overcook to 190 F and you have flan, undercook to 176 F and you have creme anglaise. The two main factors are egg concentration and cooking temperature. A: While Rudy refers to one excellent resource, it is indeed one which the authors are quite proud of ($450 on Amazon, yikes). @Yossarian provides a much better (more economical source for essentially the same information) In his first blog post: Three Books for Every Kitchen. The New Best Recipe Book, from Cooks Illustrated (Amazon, $22.97), accurately describes the coagulation process and heat concerns (with a slightly different ratio of products) it great detail beginning on page 952. In addition to the direct question you pose, "What makes Creme Brulee set?" to help you with your 'general frustration' in making Creme Brulee I would recommend this 3 minute video from Alton Brown's "Good Eats". I believe you will find it a useful resource. (should the link fail: search on YouTube for "Alton Brown Creme Brulee" and you should find the video easily)
<?php # Copyright (c) 2012 John Reese # Licensed under the MIT license $s_plugin_SourceGitphp_ = ''; $s_plugin_SourceGitphp_gitphp = 'Gitphp'; $s_plugin_SourceGitphp_title = 'Gitphp Integration'; $s_plugin_SourceGitphp_description = 'Integration für Gitphp über die VCS Basisintegration.'; $s_plugin_SourceGitphp_gitphp_root = 'Gitphp Basis-URL'; $s_plugin_SourceGitphp_gitphp_project = 'Gitphp Projekt<br/><span class="small">(inkl. ".git")</span>'; $s_plugin_SourceGitphp_master_branch = 'Hauptzweige<br/><span class="small">(kommaseparierte Liste)</span>';
/* $Id$ */ /* * Copyright (C) 2008-2011 Teluu Inc. (http://www.teluu.com) * Copyright (C) 2003-2008 Benny Prijono <benny@prijono.org> * * This program is free software; you can redistribute it and/or modify * it under the terms of the GNU General Public License as published by * the Free Software Foundation; either version 2 of the License, or * (at your option) any later version. * * This program is distributed in the hope that it will be useful, * but WITHOUT ANY WARRANTY; without even the implied warranty of * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the * GNU General Public License for more details. * * You should have received a copy of the GNU General Public License * along with this program; if not, write to the Free Software * Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA 02111-1307 USA */ #include <pj/ip_helper.h> #include <pj/addr_resolv.h> #include <pj/assert.h> #include <pj/errno.h> #include <pj/log.h> #include <pj/string.h> #include <pj/compat/socket.h> #include "os_symbian.h" #define THIS_FILE "ip_helper_symbian.cpp" #define TRACE_ME 0 static pj_status_t rsock_enum_interface(int af, unsigned *p_cnt, pj_sockaddr ifs[]) { TInt rc; RSocket rSock; TPckgBuf<TSoInetInterfaceInfo> info; unsigned i; if (PjSymbianOS::Instance()->Connection()) { rc = rSock.Open(PjSymbianOS::Instance()->SocketServ(), af, PJ_SOCK_DGRAM, KProtocolInetUdp, *PjSymbianOS::Instance()->Connection()); } else { rc = rSock.Open(PjSymbianOS::Instance()->SocketServ(), af, PJ_SOCK_DGRAM, KProtocolInetUdp); } if (rc != KErrNone) return PJ_RETURN_OS_ERROR(rc); rSock.SetOpt(KSoInetEnumInterfaces, KSolInetIfCtrl); for (i=0; i<*p_cnt && rSock.GetOpt(KSoInetNextInterface, KSolInetIfCtrl, info) == KErrNone; ) { TInetAddr &iAddress = info().iAddress; int namelen; #if TRACE_ME if (1) { pj_sockaddr a; char ipaddr[PJ_INET6_ADDRSTRLEN+2]; namelen = sizeof(pj_sockaddr); if (PjSymbianOS::Addr2pj(iAddress, a, &namelen, PJ_FALSE) == PJ_SUCCESS) { PJ_LOG(5,(THIS_FILE, "Enum: found address %s", pj_sockaddr_print(&a, ipaddr, sizeof(ipaddr), 2))); } } #endif namelen = sizeof(ifs[i]); if (PjSymbianOS::Addr2pj(iAddress, ifs[i], &namelen, PJ_TRUE) != PJ_SUCCESS) { continue; } if (ifs[i].addr.sa_family != af) continue; ++i; } rSock.Close(); // Done *p_cnt = i; return PJ_SUCCESS; } /* * Enumerate the local IP interface currently active in the host. */ PJ_DEF(pj_status_t) pj_enum_ip_interface(int af, unsigned *p_cnt, pj_sockaddr ifs[]) { unsigned start; pj_status_t status = PJ_SUCCESS; start = 0; /* Get IPv6 interface first. */ if (af==PJ_AF_INET6 || af==PJ_AF_UNSPEC) { unsigned max = *p_cnt; status = rsock_enum_interface(PJ_AF_INET6, &max, &ifs[start]); if (status == PJ_SUCCESS) { (*p_cnt) -= max; start += max; } } /* Get IPv4 interface. */ if (af==PJ_AF_INET || af==PJ_AF_UNSPEC) { unsigned max = *p_cnt; status = rsock_enum_interface(PJ_AF_INET, &max, &ifs[start]); if (status == PJ_SUCCESS) { (*p_cnt) -= max; start += max; } } *p_cnt = start; return start ? PJ_SUCCESS : PJ_ENOTFOUND; } /* * Enumerate the local IP interface currently active in the host. */ PJ_DEF(pj_status_t) pj_enum_ip_interface2( const pj_enum_ip_option *opt, unsigned *count, pj_sockaddr ifs[]) { pj_enum_ip_option opt_; if (opt && opt->omit_deprecated_ipv6) return PJ_ENOTSUP; if (opt) opt_ = *opt; else pj_enum_ip_option_default(&opt_); return pj_enum_ip_interface(opt_.af, count, ifs); } /* * Enumerate the IP routing table for this host. */ PJ_DEF(pj_status_t) pj_enum_ip_route(unsigned *p_cnt, pj_ip_route_entry routes[]) { PJ_ASSERT_RETURN(p_cnt && *p_cnt > 0 && routes, PJ_EINVAL); *p_cnt = 0; return PJ_ENOTSUP; }
Multidrug-resistance is a situation encountered in cancer patients in which the tumor becomes resistant to a variety of cytotoxic anti-cancer chemotherapeutic agents. It often involves enhanced expression of P- glycoprotein (Pgp), a plasma membrane protein. Involvement of Pgp in resistance to anti-AIDS drugs is also strongly-indicated. Pgp consists of 1280 amino acids, arranged in two repeated halves, each of which contains six predicted transmembrane helices and one ATP-binding site. It acts in an ATP-dependent manner to exclude drugs and a wide range of other hydrophobic compounds from cells, displays substantial drug- stimulated ATPase activity, and is now widely-believed to act as an ATP- driven drug-efflux pump. A catalytic cycle involving alternating catalytic sites and a mechanism for coupling of ATP-hydrolysis to drug-transport, presented by our laboratory, has become widely-adopted as a working model. We recently made a breakthrough, namely the development of a large- scale method for preparation of pure, detergent-soluble, mouse and human Pgp, using Pichia. Not only wild-type but also mutant Pgp may now be obtained in quantity, facilitating a broader range of structural, biophysical and biochemical approaches. The aim of this proposal is to characterize structure and function of Pgp. Structure will be determined by electron-microscopy and X-ray crystallography. Catalytic mechanism will be studied by specific insertion of fluorescent probes to monitor nucleotide binding parameters and occupancy of catalytic sites, and by mutagenesis of critical catalytic site residues. Coupling of ATP hydrolysis to drug transport will be investigated. The two halves of Pgp will be purified separately and reconstituted, to facilitate understanding of interactions between catalytic sites and membrane domains. Basic knowledge of this kind will be invaluable in devising ways to disable P-glycoprotein and overcome drug-resistance in patients.
Q: Radius of convergence, power series So I'm stuck with the question: Find the radius of convergence for the power series: $$f(z) = \sum^{ \infty}_{j=0} 2^{j} z^{j^2}$$ My issue is that there are two solutions depending if the $a_{n}$ is a perfect square or not, how should I approach this problem? Thanks in advance! A: Precisely for cases like this one is that Cauchy-Hadamard is used. Observe the coefficients sequence is $$a_n=\begin{cases}2^n,&n\;\text{ is a perfect square}\\{}\\0,&\text{otherwise}\end{cases}$$ and then $$\lim\sup_{n\to\infty}\sqrt[n]{a_n}=2\implies R=\frac12\;\text{is the convergence radius, by Cauchy Hadamard Formula}$$
Cycling Photos 9 November 2012 Cycling Slideshow UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Series Leader Samuel Gaze of New Zealand during the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: (L to R) 4th Place Mathieu van der Poel of the Netherlands, 2nd Place Nino Schurter of Switzerland, 1st Place Samuel Gaze of New Zealand, 3rd Place Maxime Marotte of France and 5th Place Titouan Carod of France during the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: 2nd Place Nino Schurter of Switzerland, 1st Place Samuel Gaze of New Zealand and 3rd Place Maxime Marotte of France celebrate during the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: (L to R) 4th Place Mathieu van der Poel of the Netherlands, 2nd Place Nino Schurter of Switzerland, 1st Place Samuel Gaze of New Zealand, 3rd Place Maxime Marotte of France and 5th Place Titouan Carod of France during the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Samuel Gaze of New Zealand celebrates winning the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Nino Schurter of Switzerland reats after his foot unclipped as Samuel Gaze of New Zealand races for the line during the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Nino Schurter of Switzerland leads Samuel Gaze of New Zealand during the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Nino Schurter of Switzerland during the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Nino Schurter of Switzerland during the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Samuel Gaze of New Zealand during the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Nino Schurter of Switzerland leads Samuel Gaze of New Zealand during the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: The start of the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: A bottle neck at the first corner during the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: The start of the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: The start of the Elite Mens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Series leader Annika Langvad of Denmark during the Elite Womens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Series leader Annika Langvad of Denmark during the Elite Womens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Annika Langvad of Denmark during the Elite Womens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Annika Langvad of Denmark during the Elite Womens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Annika Langvad of Denmark during the Elite Womens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) UCI Mountain Bike World Cup STELLENBOSCH, SOUTH AFRICA - MARCH 10: Annika Langvad of Denmark during the Elite Womens race of the UCI Mountain Bike World Cup on March 10, 2018 in Stellenbosch, South Africa. (Photo by Shaun Roy/Gallo Images/Getty Images) Vuelta a Espana - Stage 21 MADRID, SPAIN - SEPTEMBER 10: Alberto Contador of Spain and team Trek Segafredo celebrates with the crowd after finishing 5th overall in the Vuelta a Espana cycling race after the Stage 21 in Cibeles square on September 10, 2017 in Madrid, Spain. This was Alberto Contador's last race after recently announcing his retirement. (Photo by Gonzalo Arroyo/Getty Images for CA Technologies) Vuelta a Espana - Stage 21 MADRID, SPAIN - SEPTEMBER 10: Alberto Contador of Spain and team Trek Segafredo celebrates with the crowd after finishing 5th overall in the Vuelta a Espana cycling race after the Stage 21 in Cibeles square on September 10, 2017 in Madrid, Spain. This was Alberto Contador's last race after recently announcing his retirement. (Photo by Gonzalo Arroyo/Getty Images for CA Technologies) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Britain's Chris Froome of Team Sky celebrates on the podium after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Britain's Chris Froome of Team Sky celebrates with his trophy towards the crowd of spectators on the podium after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Britain's Chris Froome (centre) of Team Sky celebrates on the podium with second placed Italy's Vincenzo Nibali (L) of the Bahrain-Merida's team and third placed Russian cyclist Ilnur Zakarin of Team Katusha Alpecin after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Britain's Chris Froome of Team Sky celebrates on the podium after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Britain's Chris Froome of Team Sky celebrates on the podium after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Britain's Chris Froome of Team Sky celebrates on the podium after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Britain's Chris Froome of Team Sky celebrates with his trophy on the podium after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Britain's Chris Froome of Team Sky celebrates with his trophy for winning the Tour de France and Vuelta a Espana in the same year on the podium after winning the Vuelta a Espana race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Britain's Chris Froome (centre) of Team Sky celebrates on the podium with second placed Italy's Vincenzo Nibali (L) of the Bahrain-Merida's team and third placed Russian cyclist Ilnur Zakarin of Team Katusha Alpecin after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Britain's Chris Froome (centre) of Team Sky celebrates on the podium with second placed Italy's Vincenzo Nibali (L) of the Bahrain-Merida's team and third placed Russian cyclist Ilnur Zakarin of Team Katusha Alpecin after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Britain's Chris Froome of Team Sky celebrates on the podium after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 MADRID, SPAIN - SEPTEMBER 10: Britain's Chris Froome (C) of Team Sky celebrates with teammates on the podium after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Alberto Contador waves with members of his Trek team after Stage 21 of the Vuelta a Espana race on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 Madrid, SPAIN - SEPTEMBER 10: Team manager Alexander Vinokourov (L) and the Astana team celebrate as 'Best Team of the Vuelta' after Stage 21 of the Vuelta a Espana race on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 MADRID, SPAIN - SEPTEMBER 10: Britain's Chris Froome (C) of Team Sky celebrates on the podium with second placed Italy's Vincenzo Nibali (L) of the Bahrain-Merida's team and third placed Russian cyclist Ilnur Zakarin of Team Katusha Alpecin after winning the Vuelta a Espana cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 MADRID, SPAIN - SEPTEMBER 10: Britain's Chris Froome (4L) of Team Sky celebrates with teammates on the podium after winning the Vuelta a Espaa cycling race after the Stage 21 on September 10, 2017 in Madrid, Spain. (Photo by Denis Doyle/Getty Images) Vuelta a Espana - Stage 21 MADRID, SPAIN - SEPTEMBER 10: Alberto Contador of Spain and team Trek Segafredo celebrates with the crowd after finishing 5th overall in the Vuelta a Espana cycling race after the Stage 21 in Cibeles square on September 10, 2017 in Madrid, Spain. This was Alberto Contador's last race after recently announcing his retirement. (Photo by Gonzalo Arroyo/Getty Images for CA Technologies)
package zmaster587.advancedRocketry.client.render; import net.minecraft.block.state.IBlockState; import net.minecraft.client.Minecraft; import net.minecraft.client.renderer.*; import net.minecraft.client.renderer.entity.Render; import net.minecraft.client.renderer.entity.RenderManager; import net.minecraft.client.renderer.texture.TextureMap; import net.minecraft.client.renderer.tileentity.TileEntityRendererDispatcher; import net.minecraft.client.renderer.tileentity.TileEntitySpecialRenderer; import net.minecraft.client.renderer.vertex.DefaultVertexFormats; import net.minecraft.entity.Entity; import net.minecraft.tileentity.TileEntity; import net.minecraft.util.ResourceLocation; import net.minecraft.util.math.BlockPos; import net.minecraftforge.fml.client.registry.IRenderFactory; import org.lwjgl.opengl.GL11; import zmaster587.advancedRocketry.api.IInfrastructure; import zmaster587.advancedRocketry.entity.EntityRocket; import zmaster587.advancedRocketry.util.StorageChunk; public class RendererRocket extends Render implements IRenderFactory<EntityRocket> { private static BlockRendererDispatcher renderBlocks = Minecraft.getMinecraft().getBlockRendererDispatcher(); public RendererRocket(RenderManager manager) { super(manager); } //TODO: possibly optimize with GL lists @Override public void doRender(Entity entity, double x, double y, double z, float f1, float f2) { StorageChunk storage = ((EntityRocket)entity).storage; BufferBuilder buffer = Tessellator.getInstance().getBuffer(); if(storage == null || !storage.finalized) return; if(entity.getPassengers().contains(Minecraft.getMinecraft().player)) { y = +0.5 -((EntityRocket)entity).stats.getSeatY(); } //Find the halfway point along the XZ plane float halfx = storage.getSizeX()/2f; float halfz = storage.getSizeZ()/2f; GL11.glPushMatrix(); GL11.glTranslatef((float)x, (float)y, (float)z); GlStateManager.enableBlend(); GlStateManager.blendFunc(GL11.GL_ONE, GL11.GL_ONE); GlStateManager.color(0.5f, 1f, .5f, .2f); GlStateManager.disableTexture2D(); GL11.glEnable(GL11.GL_LINE_STIPPLE); GL11.glLineWidth(1f); GL11.glLineStipple(5, (short)0x2222); if(!((EntityRocket)entity).isInFlight()) { for(IInfrastructure inf : ((EntityRocket)entity).getConnectedInfrastructure()) { if(inf.canRenderConnection()) { TileEntity tile = (TileEntity)inf; buffer.begin(GL11.GL_LINE_LOOP, DefaultVertexFormats.POSITION); buffer.pos(0, storage.getSizeY()/2f, 0).endVertex(); buffer.pos((tile.getPos().getX() - entity.posX + 0.5f)/2f, storage.getSizeY()/2f, (tile.getPos().getZ() - entity.posZ + 0.5f)/2f).endVertex(); buffer.pos(tile.getPos().getX() - entity.posX + 0.5f, tile.getPos().getY() - entity.posY + 0.5f, tile.getPos().getZ() - entity.posZ + 0.5f).endVertex(); buffer.pos((tile.getPos().getX() - entity.posX + 0.5f)/2f, storage.getSizeY()/2f, (tile.getPos().getZ() - entity.posZ + 0.5f)/2f).endVertex(); //RenderHelper.renderCrossXZ(Tessellator.instance, .2f, 0, storage.getSizeY()/2f, 0, tile.xCoord - entity.posX + 0.5f, tile.yCoord - entity.posY + 0.5f, tile.zCoord - entity.posZ + 0.5f); //RenderHelper.renderBlockWithEndPointers(Tessellator.instance, .2f, 0, storage.getSizeY()/2f, 0, tile.xCoord - entity.posX, tile.yCoord - entity.posY, tile.zCoord - entity.posZ); Tessellator.getInstance().draw(); //RenderHelper.renderCubeWithUV(tess, 0, 0, 0, 2, 55, 2, 0, 1, 0, 1); } } } GlStateManager.color(1f, 1f, 1f); GlStateManager.disableBlend(); GL11.glDisable(GL11.GL_LINE_STIPPLE); GlStateManager.enableTexture2D(); GL11.glPopMatrix(); //Initial setup if(storage.world.displayListIndex == -1) { storage.world.displayListIndex = GLAllocation.generateDisplayLists(1); GL11.glPushMatrix(); GL11.glNewList(storage.world.displayListIndex, GL11.GL_COMPILE); net.minecraft.client.renderer.RenderHelper.disableStandardItemLighting(); //Render Each block Minecraft.getMinecraft().getTextureManager().bindTexture(TextureMap.LOCATION_BLOCKS_TEXTURE); for(int xx = 0; xx < storage.getSizeX(); xx++) { for(int zz = 0; zz < storage.getSizeZ(); zz++) { for(int yy = 0; yy < storage.getSizeY(); yy++) { IBlockState block = storage.getBlockState(new BlockPos(xx, yy, zz)); buffer.begin(GL11.GL_QUADS, DefaultVertexFormats.BLOCK); try { Minecraft.getMinecraft().getBlockRendererDispatcher().renderBlock(block, new BlockPos(xx, yy, zz), storage.world, buffer); } catch (NullPointerException e) { System.out.println(block.getBlock().getUnlocalizedName() + " cannot be rendered on rocket at " + entity.getPosition()); } Tessellator.getInstance().draw(); } } } net.minecraft.client.renderer.RenderHelper.enableStandardItemLighting(); GL11.glEndList(); GL11.glPopMatrix(); } GL11.glPushMatrix(); GL11.glTranslatef((float)x - halfx, (float)y, (float)z - halfz); Minecraft.getMinecraft().getTextureManager().bindTexture(TextureMap.LOCATION_BLOCKS_TEXTURE); GL11.glCallList(storage.world.displayListIndex); //Render tile entities if applicable for(TileEntity tile : storage.getTileEntityList()) { TileEntitySpecialRenderer renderer = (TileEntitySpecialRenderer)TileEntityRendererDispatcher.instance.renderers.get(tile.getClass()); if(renderer != null ) { TileEntityRendererDispatcher.instance.render(tile, tile.getPos().getX(), tile.getPos().getY(), tile.getPos().getZ(), f1); //renderer.renderTileEntity(tile, tile.getPos().getX(), tile.getPos().getY(), tile.getPos().getZ(), f1, 0); } } //net.minecraft.client.renderer.RenderHelper.disableStandardItemLighting(); GlStateManager.enableLighting(); GlStateManager.color(1, 1, 1); GL11.glPopMatrix(); //Clean up and make player not transparent OpenGlHelper.glBlendFunc(GL11.GL_SRC_ALPHA, GL11.GL_ONE_MINUS_SRC_ALPHA, 0, 0); } @Override protected ResourceLocation getEntityTexture(Entity p_110775_1_) { return null; } @Override public Render<? super EntityRocket> createRenderFor(RenderManager manager) { return new RendererRocket(manager); } }
REFILE-UBS to lead European cross-border business from Switzerland 3 分钟阅读 (Refiles April 19 story to clarify description of northern European markets with looser cross-border regulations) By Brenna Hughes Neghaiwi and Angelika Gruber ZURICH, April 19 (Reuters) - UBS will centralise its European cross-border wealth management business and run it out of Switzerland from June, the latest step within a series of reshuffles since merging its flagship business under one global unit this year. The world’s largest wealth manager will handle cross-border business for western Europe out of two regional units to help adapt the offshore business to differing regulations, according to an internal memo seen by Reuters. “The separation between Europe International North and South allows us to take strategic decisions based on market access regulations, which are tighter in southern Europe than in the north,” the bank’s new head of wealth management for Europe, the Middle East and Africa, Christine Novakovic, said in the memo sent on Thursday. Many wealthy European clients seek to book money not only in their home country but also through additional accounts booked in Switzerland, the world’s largest centre for offshore wealth. In some countries, foreign bankers may travel to court new clients or make visits to existing customers on their home turf. But countries such as Italy, Spain and France impose tighter restrictions than several important northern European markets against cross-border visits and marketing, meaning banks focus more on attracting offshore clients from these countries who already have a Swiss bank account. Novakovic will directly oversee the southern unit —including Italy, Iberia, France and the Benelux — on an interim basis, while Sonia Goessi will lead the northern unit, consisting of cross-border business from Germany, Austria, Britain, the Nordics and Netherlands. The bank will reintegrate its business for so-called affluent clients — private banking customers with under 2 million Swiss francs ($2.1 million) managed by the bank — into the same organisational structure as its high net worth clients, in order to help boost business as their assets grow.
Journey Costume DLC floating over to LittleBigPlanet 2 Everybody wants a piece of the warmly received Journey – even Sackboy. Media Molecule has developed an adorable Journey costume for their hit game LittleBigPlanet 2. Sackboy has never looked quite so…mysterious. Additionally, there will also be a Journey sticker pack available. Both of these items will go on sale sometime next month. The costume is expected to be priced at the standard $2. Furthermore, the image above is a wallpaper to whet your appetite. It can be downloaded in a variety of sizes for the PSP, PS3 and PC from here. If you don’t know what all the Journey fuss is about, shame on you. Now that you’ve been shamed, click here.
Categories The High Court has granted a father the right to see his daughter eight times a year, after a court order forbidding him from applying for more contact expired. Re G concerned the parents of a 13 year-old girl who had split acrimoniously before she was born. For the first six years of her life her parents returned regularly to court to argue over contact and the proceedings eventually became intractable. At that point a Cafcass officer was appointed as the girl’s legal guardian. The father saw his daughter regularly but the frequency of the visits gradually declined. A psychiatrist decided that the father had developed a near obsession with his daughter and also said he experienced mood swings and could be aggressive at times. A legal order was granted giving him the right to see the girl three times a year but he was also not allowed to contact his daughter’s school or her GP, or to go within four miles of the mother’s home. Then a ‘section 91 (14)’ order was issued against him. Issued under the Children Act 1989, these prohibit legal applications regarding the affected children, for example for more contact, without the prior approval of the court. The section 91 (14) order ran for a period of six years. The day after it expired, the father wrote to the girl’s mother to discuss the arrangements in place for contact, but she accused him of harassing and manipulating their daughter. The mother had not told the girl about the legal quarrels between her parents and she did not know why she only saw her father occasionally. The father went to court to argue that contact arrangements should be reviewed now that the section 91 (14) order had expired. At the High Court, a case worker from the National Youth Advocacy Service said the father “lacked insight” into why contact had been restricted to three times a year and said there was still a possibility that the father might try to manipulate his now teenage daughter. On the other hand, the girl was interested in seeing her father more frequently. Judge Bellamy considered the practicality of an order for more contact. He concluded that the child’s clearly expressed wishes should be taken into consideration, given her age and understanding of the situation. He increased contact to eight times per year, but also put in place a new section 91 (14) order, which would stay in place until the girl turned 16. Comments(10) I bet 90% of the problems here derived from the courts own failures in not acting decisively from the off to protect a child’s paternal relationship and give the father a decent chance. The predictable garbage about “lack of insight” trotted out by Cafcass and the psychiatrist could as equally be applied to themselves. Name me someone who does not get occasional mood swings or who does not get aggressive at times. What are fathers meant to be, perfect? It appears the psychiatrist has described a perfectly normal human being, perhaps he or she was expecting a Truman Burbank character! I’ve never trusted psychiatrists/psychologists ever since watching a program about badly behaved children. A woman psychiatrists/psychologist on the program thought a Welsh father was confusing his child by saying “let’s do this is it?”. According to the very well spoken English woman psychiatrist the father’s use of “is it” when suggesting some sort of activity to the child was a cause for concern, and could be adversely affecting the child and contributing towards the child’s bad behaviour. What the poor woman didn’t realise is that at least half the Welsh population use the term “is it”, it’s a bloody Welshism!!! It does seem extraordinary that a psychiatrist came to this extremely punitive decision when clearly there is no threat to the child (or we would know about it) and the child is confused because she doesn’t where her father has gone and wants him back. The psychiatrist says the father has “developed a near obsession” with seeing his daughter – this is absurd – parents need to be virtually obsessed with their children or nobody would put up with the cost and aggravation of raising them ! In years to come when this seemingly idiotic psychiatrist has moved on and forgotten about this girl the father will still be “nearly obsessed” with his daughter – I hope. I have to ask the same question again – can anybody see a likelihood of the mother being treated like this ??? Many Psychiatrist from what i have seen and read should have assessments themselves. there have been many published reports of how they behave for example the one last year who has been reported to the GMC for diagnosing a girl with Bipolar Disorder when she hadn’t in order to get her newborn adopted to satisfy the L Authority. How do these experts live with their conscience? Material wealth must out-way morality. I conclude we have many immoral people working in positions of trust therefore we all need to be vigilant and expose them. Could i point out the obvious – how much money did the legal aid or private lawyers, barristers, psychiatrists, social services, cafcass, the courts and judges and his psychotic ex wife make from this man and his quest to see his daughter? At the expense of the irreversible psychological and emotional damage they have all collectively inflicted on an innocent child? Could someone put a figure on it? I bet its obscene! Everything about this picture is wrong. Shame on them. Only psychiatrist I ever knew was a sexual deviant and pervert and into some well dodgy practices in that department and had to pay sometimes as which ever partner he was with usually wouldn’t do it. They also have their bad points. The wording is interesting here. This man was found to be dangerous (like so many others) because he was ‘obsessive’ with his daughter. What else are you with your children when someone is trying to take them away from you? Are you calm and uninterested? The person who chose the word ‘obsessive’ here seems to be trying to imply something a lot more sinister, and no doubt the average reader would fall for this cool twist in language. It is such manipulation of the language that allows family law in Britain to go unchecked, and to continue to kill relationships. Leave a Reply Stowe Family Law LLP is authorised and regulated by the Solicitors Regulation Authority. SRA ref 469401. Stowe Family Law LLP is registered with Companies House, ref. OC331570, and registered for VAT, number 918 5722 04. Calls may be recorded for quality and training purposes.
China slams 'irresponsible' Trump accusations over North Korea US President Donald Trump (L, pictured November 2018) said he did not expect to meet his Chinese counterpart Xi Jinping before March 1, leading to a slump in world stock markets China on Saturday called Donald Trump "irresponsible" after the US President cancelled his top diplomat's latest trip to North Korea and suggested Beijing was stalling efforts to disarm Pyongyang. US Secretary of State Mike Pompeo was due to return to North Korea next week for what he described as the next stage in ensuring the "final, fully verified denuclearization of North Korea". But Trump -- facing a slew of domestic problems and independent reports that North Korea has done little or nothing to roll back its nuclear program -- vetoed the plan on Friday. "Because of our much tougher trading stance with China, I do not believe they are helping with the process of denuclearization as they once were," despite UN sanctions against the nuclear-armed regime, Trump said. Beijing hit back at Trump's "capricious" accusations in a statement posted on the foreign ministry website. "The US statement is contrary to basic facts and is irresponsible. We are seriously concerned about this," Chinese foreign ministry spokesman Lu Kang said in the statement. "All parties concerned should... show more sincerity and flexibility, instead of being capricious and put the blame on others," he said. The trip would have been Pompeo's fourth to North Korea, and the second since a historic summit on June 12 between Trump and Kim in Singapore. Trump said on Friday that Pompeo would still head to North Korea "in the near future," saying this would likely occur when the US-China trading relationship is "resolved." The world's two largest economies are engaged in an escalating trade war, exchanging tit-for-tat tariffs on $100 billion in goods, with the most recent levies imposed by both sides on Thursday.
Q: Vaadin - drag & drop with control key Is it possible to find out if some key is pressed during dragging in vaadin? I would like if user could copy item by dragging with pressed Ctrl. A: In drop method just use this: TreeTargetDetails treeTargetDetails = ((TreeTargetDetails) event.getTargetDetails()); MouseEventDetails mouseEventDetails = MouseEventDetails.deSerialize((String) treeTargetDetails.getData("mouseEvent")); if (mouseEventDetails.isCtrlKey()) { ... }
Q: Auto.arima with xreg in R, restriction on forecast periods I am using the forecast package and implement auto.arima with xreg. Here I want to forecast only for 1 year ahead but I am unable to use h parameter in the forecast function. Below is the reason for that: Definition is given in manual(F1 check): h = "Number of period of forecast but if xreg is used 'h' is ignored and the forecast period will be number of rows" Please suggest me an alternate way to use h for the specific period forecast. A: Using xreg suggests that you have external (exogenous) variables. In this, a regression model is fitted to the external variables with ARIMA errors. When forecasting you need to provide future values of these external variables. In practice, these are often forecasts or could be known. For example, if you're trying to predict Sales and you use Advertising spend as an external variable, you may know the advertising spend for the upcoming year. auto.arima then produces forecasts for the length of xreg, therefore disregarding h. Based on your comments below, I've provided an example script demonstrating this based on the Sales example above. library(forecast) # Generate sample data sales <- sample(100:170, 4*10, replace = TRUE) advertising <- sample(50:70, 4*10, replace = TRUE) # Create time series objects. sales_ts <- ts(sales, frequency = 4, end = c(2017, 4)) fit <- auto.arima(sales_ts, xreg = advertising) # If we pass external_regressor into the forecast, h will be disregarded and we will # get a forecast for length(external_regressor) wrong_forecast = forecast(fit, h = 4, xreg = advertising) length(wrong_forecast) # Will be 40 # To forecast four quarters in advance, we must provide forecasted external regressor data # for the upcoming four quarters, so that length(new_regressor) == 4. # In reality, this data is either forecasted from another forecast, or is known. We'll randomly generate it. upcoming_advertising <- sample(50:70, 4, replace = TRUE) correct_forecast <- forecast(fit, xreg = upcoming_advertising) length(correct_forecast$mean) # Will be 4 The key things to note are: If we forecast with the same regressors as we did when generating the forecast, h will be disregarded and a forecast will be generated for the length of xreg in your case, 10 years. As such, we must provide new data for xreg for the length of time we wish to forecast - in your case, 4 quarters.
United Nations General Assembly Resolution 3379 United Nations General Assembly Resolution 3379, adopted on 10 November 1975 by a vote of 72 to 35 (with 32 abstentions), "determine[d] that Zionism is a form of racism and racial discrimination". The vote took place approximately one year after UNGA 3237 granted the PLO "observer status", following PLO president Yasser Arafat's "olive branch" speech to the General Assembly in November 1974. The resolution was passed with the support of the Soviet bloc, in addition to the Arab- and Muslim-majority countries, many African countries, and a few others. The determination that "Zionism is a form of racism and racial discrimination", contained in the resolution, was revoked in 1991 with UN General Assembly Resolution 46/86. Background In July 1920, at the San Remo conference, a Class "A" League of Nations mandates over Palestine was allocated to the British. The preamble of the mandate document declared: Whereas the Principal Allied Powers have also agreed that the Mandatory should be responsible for putting into effect the declaration originally made on November 2nd, 1917, by the Government of His Britannic Majesty, and adopted by the said Powers, in favour of the establishment in Palestine of a national home for the Jewish people, it being clearly understood that nothing should be done which might prejudice the civil and religious rights of existing non-Jewish communities in Palestine, or the rights and political status enjoyed by Jews in any other country. On 29 November 1947, the UN General Assembly adopted a resolution recommending "to the United Kingdom, as the mandatory Power for Palestine, and to all other Members of the United Nations the adoption and implementation, with regard to the future government of Palestine, of the Plan of Partition with Economic Union" as Resolution 181 (II). The plan contained a proposal to terminate the British Mandate for Palestine and partition Palestine into "independent Arab and Jewish States and the Special International Regime for the City of Jerusalem." On 14 May 1948, the day on which the British Mandate over Palestine expired, the Jewish People's Council gathered at the Tel Aviv Museum, and approved a proclamation which declared the establishment of a Jewish state in Eretz Israel, to be known as the State of Israel. On 11 May 1949, Israel was admitted to membership in the United Nations. The resolution of 1975 The full text of Resolution 3379: Response Israel In his address to the United Nations General Assembly the same day, 10 November 1975, Israeli Ambassador Chaim Herzog stated: Herzog ended his statement, while holding a copy of the resolution, with these words: As he concluded his speech, Herzog tore the resolution in half. The name of "The UN avenue" in Haifa, Jerusalem and Tel Aviv was switched to "The Zionism avenue" as a response to the UN's decision. United States Before the vote, Daniel Patrick Moynihan, the United States ambassador to the United Nations, warned that, "The United Nations is about to make anti-Semitism international law." He delivered a speech against the resolution, including the famous line, "[The United States] does not acknowledge, it will not abide by, it will never acquiesce in this infamous act ... A great evil has been loosed upon the world." In Campbell, California, in the United States, a group of high school students attempted to solicit signatures on the premises of a local shopping center for a petition against Resolution 3379. The result was the landmark U.S. Supreme Court decision in Pruneyard Shopping Center v. Robins (1980) that supported states' rights to expand the exercise of free speech, which California held was legal in what were considered public areas of a shopping mall. Mexico's vote in favor of the resolution led some United States Jews to organize a tourism boycott of Mexico. This ended after Mexican foreign minister Emilio Óscar Rabasa made a trip to Israel (Rabasa shortly afterward was forced to resign). Voting record for Resolution 3379 Revocation United Nations General Assembly Resolution 46/86, adopted on 16 December 1991, revoked the determination in Resolution 3379, which had called Zionism a form of racism. Israel had made revocation of Resolution 3379 a condition of its participation in the Madrid Peace Conference, in progress in the last quarter of 1991. The resolution was raised under pressure from the administration of US President George H.W. Bush. The text of the revocation was simply: "The General Assembly Decides to revoke the determination contained in its resolution 3379 (XXX) of 10 November 1975." The motion was supported by 111 (including the 90 nations who sponsored the resolution), opposed by 25 nations and abstained by 13 nations. Voting record for Resolution 46/86 Statement of revocation George H. W. Bush personally introduced the motion to revoke 3379 with these words: See also World Conference against Racism African Charter on Human and Peoples' Rights References External links United Nations General Assembly Resolution 3379 (10 November 1975) (Official UN site) Report of the Plenary Meeting A/PV.2400 (Official UN site) Israeli Ambassador Herzog's response to Zionism is racism resolution (10 November 1975) Ambassador Moynihan's response to Zionism is racism resolution Video footage of Ambassador Herzog concluding his remarks and tearing the resolution in half (10 November 1975) American Jewish Committees' extensive archive of materials on the Zionism is Racism controversy Category:1975 in law Category:Anti-Zionism 3379 Category:United Nations General Assembly resolutions concerning Israel Category:Zionism Category:1975 in the United Nations Category:Politics and race Category:Criticism of the United Nations Category:November 1975 events Category:Israel, Palestine, and the United Nations
However, Indiana's NewsCenter wanted to know what are local farmers doing to keep their eggs safe? Executives at Creighton Brothers in Warsaw, Indiana said constant monitoring and testing is key in prevent a salmonella outbreak in Northeast Indiana. Farmers at Creighton Brothers check back chicks, their feed supply and the environment inside and outside their plant for traces of salmonella. It is a process that they voluntarily implemented in the 1990's. "We wouldn't be around long if we didn't take that very seriously and so that's why we go to such steps... voluntary testing and everything as well as any kind of government oversight, mandated testing. We take it all very seriously," said Creighton Brothers Vice President Mindy Truex. Creighton Brothers is a family-owned company that has been in business since 1925. Meanwhile, if any shelled eggs were found to contain salmonella, they would not be shipped out. The eggs would be sent to Creighton's "breaking plant". At that plant, the eggs would be cracked open and pasteurized at a high temperature, which would effectively kill any lingering bacteria. Across the nation, 1,300 cases of salmonella poisoning have been linked to the recall. Meanwhile, experts believe that number will continue to go up. According to the Journal Gazette, the Apple Glen and Southtown Crossing Walmart stores had three recalled brands on their shelves up until Friday, August 20. Sunny Farms, Sunny Meadow and Hillandale Farms all have specific batches that have been recalled. Locally, Meijer, Kroger and Scott's were not affected. If you purchased any of the recalled brands, check your egg carton for plant number P-1860 with Julian dates between 99 to 230 or plant number P-1663 with Julian dates ranging from 137 to 230. Any cartoon matching those specific numbers was recalled. Do not eat any recalled eggs. You can return them to the store for a refund. Meanwhile, for egg safety tips, click the link in the related content section on this article. What are your thoughts CLICK HERE to leave us a "QUESTION OF THE DAY” comment. Want to be in the know for the next weather event, the next school closing or the next big breaking news story? TextCaster alerts from 21Alive.com are your defining source for instant information delivered right to your cell phone and email. It's free, easy and instant. Sign-Up Now!Powered by Summit City Chevrolet
Interindividual variation in pubertal growth patterns of ventilatory function, standing height, and weight. We studied interindividual variation in pubertal growth patterns from peak growth velocities (PGV) and peak growth ages (PGA) of ventilatory function, standing height, and weight in a selection of 144 boys from a longitudinal survey of 404 pupils in a Dutch secondary school. Measurements were made at intervals of approximately 0.5 yr between 1978 and 1985. Between 9 and 14 measurements were available for each selected individual. Average age on enrollment was 12.7 years. Ventilatory function was characterized by FVC, FEV1, peak expiratory flow (PEF), and maximal expiratory flow at 50% of the FVC (MEF50), derived from maximum expiratory flow volume (MEFV) curves. PGVs and PGAs were derived from monotonically increased regression splines, fitted to the data of each individual and each variable separately. The 90% percentile ranges of PGA were approximately 4.5 yr in all variables. In almost all boys, the PGA of height occurred earlier than that of ventilatory function, but the magnitude of the time lag varied considerably. Median PGAs agreed well with peak growth ages derived from average growth velocity curves fitted on exactly the same data. However, median PGVs were 1.25 to 1.40 times higher than the corresponding estimates from the average curves. The latter finding implies that in almost all cases, individual development deviates considerably from development suggested by average growth profiles. No differences in PGA and PGV were found between subjects with a prepubertal history of respiratory symptoms and those without. The large interindividual variations in PGA and PGV, and in the time lag between growth of height and of ventilatory function, are not accounted for in cross-sectional reference equations. These equations are therefore not suitable to predict individual development during adolescence.
Imperial, Missouri Imperial is a census-designated place (CDP) in Jefferson County, Missouri, United States. The population was 4,709 at the 2010 census, up from 4,373 in 2000. It was originally known as West Kimmswick, and is located south of downtown St. Louis. St. John's Church is a historic parish church located within Imperial. Geography Imperial is located in northeastern Jefferson County at . According to the United States Census Bureau, the CDP has a total area of , of which are land and , or 13.01%, are water. Imperial is bordered to the north by Arnold, to the south by Barnhart, and to the east by the Mississippi River, which forms the Illinois state line. The CDP surrounds the city of Kimmswick. Interstate 55 runs through Imperial, with access from Exits 185 (Secondary Route M) and 186 (Main Street). Mastodon State Historic Site is located in Imperial. Demographics 2010 census As of the census of 2010, there were 4,709 people, 1,769 households, and 1,297 families living in the CDP. The population density was . There were 1,871 housing units at an average density of . The racial makeup of the CDP was 97.5% White, 0.3% African American, 0.3% Native American, 1.1% Asian, 0.1% from other races, and 0.8% from two or more races. Hispanic or Latino of any race were 1.2% of the population. There were 1,769 households of which 36.2% had children under the age of 18 living with them, 58.0% were married couples living together, 9.6% had a female householder with no husband present, 5.7% had a male householder with no wife present, and 26.7% were non-families. 21.3% of all households were made up of individuals and 6.9% had someone living alone who was 65 years of age or older. The average household size was 2.66 and the average family size was 3.08. The median age in the CDP was 38 years. 24.8% of residents were under the age of 18; 8.1% were between the ages of 18 and 24; 27.2% were from 25 to 44; 29.3% were from 45 to 64; and 10.6% were 65 years of age or older. The gender makeup of the CDP was 50.9% male and 49.1% female. 2000 census As of the census of 2000, there were 4,373 people, 1,634 households, and 1,228 families living in the CDP. The population density was 812.4 people per square mile (313.8/km²). There were 1,720 housing units at an average density of 319.5 per square mile (123.4/km²). The racial makeup of the CDP was 97.92% White, 0.14% African American, 0.14% Native American, 0.34% Asian, 0.02% Pacific Islander, 0.11% from other races, and 1.33% from two or more races. Hispanic or Latino of any race were 1.17% of the population. There were 1,634 households out of which 38.7% had children under the age of 18 living with them, 59.7% were married couples living together, 10.3% had a female householder with no husband present, and 24.8% were non-families. 20.3% of all households were made up of individuals and 6.7% had someone living alone who was 65 years of age or older. The average household size was 2.67 and the average family size was 3.06. In the CDP, the population was spread out with 27.6% under the age of 18, 8.3% from 18 to 24, 34.1% from 25 to 44, 21.5% from 45 to 64, and 8.5% who were 65 years of age or older. The median age was 34 years. For every 100 females, there were 100.6 males. For every 100 females age 18 and over, there were 93.4 males. The median income for a household in the CDP was $49,565, and the median income for a family was $58,955. Males had a median income of $39,292 versus $30,191 for females. The per capita income for the CDP was $20,431. About 4.9% of families and 9.8% of the population were below the poverty line, including 13.7% of those under age 18 and 8.9% of those age 65 or over. Education Almost all of the Imperial CDP is in the Windsor C-1 School District. A small portion of the CDP and several surrounding areas with Imperial addresses are zoned to the Fox C-6 School District. The Windsor district operates Windsor High School in the CDP. Fox C-6 operates Seckman High School outside of the CDP. The Windsor district previously ended at the eighth grade. High school students would attend Crystal City High School or Herculaneum High School. The Fox district was originally a K-8 school district, with high school students also having a choice of Crystal City High and Herculaneum High. The Fox district became K-12 when Fox High School was established in 1955. References Category:Census-designated places in Jefferson County, Missouri Category:Census-designated places in Missouri Category:Missouri populated places on the Mississippi River
The violence of (in)action: communities, climate and business-as-usual Climate change is creating challenges and opportunities for community development. The challenges arise from declining biophysical conditions and the socio-political and economic barriers that delay, delegitimize or co-opt genuine community responses. Opportunities are arising from global climate change activism networks that provide new resources and discourses for activists and community organizers. These challenges and opportunities are unevenly shaped by the possibility for genuine democratic contestation in different contexts. In this article we draw on recent climate justice mobilizations in Aotearoa New Zealand. These mobilizations called for divestment from fossil fuel activities by blocking access to major banks around the country that directly support the industry. While most actions in the campaign were peaceful and effective in closing down business-as-usual for the day at specific bank branches, one in particular provoked police and implicit state-sanctioned violence against the activists, pitting bank customers against climate activists. We use this case study to illustrate the complexity of contemporary climate activism and tactics within communities, and draw on the work of Judith Butler to show how violence and stigma are used to discipline certain bodies who contest more dominant development trajectories and investment.
How Three Agencies Weathered the 2013 Shutdown In the same week that Republican Senate leader Mitch McConnell, R-Ky., vowed to avoid future government shutdowns, the Governmental Accountability Office weighed in on Friday with new documentation on the disruption visited upon three agencies during the October 2013 16-day closure. Cessation of patient registration for clinical trials, delays in graduation of Merchant Marine Academy students, postponed public transit grants, and shuttered environmental management offices were some of the effects of the expired appropriations at the National Institutes of Health and the Transportation and Energy departments, GAO found. Carried out at the request of Sen. Mark Warner, D-Va., who chairs the Senate Budget Committee’s Government Performance Task Force, GAO focused on units in three departments GAO selected “based on the value of grants and contracts, the percentage of employees expected to be furloughed, and the potential for longer-term effects,” the report said. Auditors reviewed department contingency plans and economic forecasters’ analyses, while interviewing officials from the Bureau of Economic Analysis, the Office of Management and Budget, the Office of Personnel Management and associations. Auditors also cross-checked the data used in OMB ‘s year-old publication “Costs of the October 2013 Federal Government Shutdown,” finding them reliable. Within the Health and Human Services Department, “grants management activities at NIH effectively ceased with employee furloughs, although most current grant recipients were able to draw down funds,” GAO noted. “NIH had to reschedule the review process for over 13,700 grant applications because of the shutdown. After the shutdown, NIH completed the process to meet the next milestone in January 2014.” At Transportation, the Federal Transit Administration “effectively ceased with grants management officials furloughed and no payments made on existing grants,” GAO said. FTA officials said that no new grant awards were processed because of the shutdown, “but the effect was minimal because the grant processing system is typically unavailable in early October for fiscal year closeout activities.” At Energy’s Office of Environmental Management, “contract activities generally continued because of the availability of multi-year funding, but more than 1,700 contractor employees who operate and maintain EM facilities were laid off or required to use leave because EM issued stop-work orders. EM officials reported some programs required four months to return to pre-shutdown levels of contract activity,” the report said. Some of the potential disruption—economic estimates of which GAO also examined—was mitigated by the selected department’s “experience with preparing for prior potential shutdowns, funding flexibilities (such as multi-year funding), and ongoing communications internally” with OMB and OPM, the auditors found. “OMB staff addressed questions from agencies on how to communicate about the shutdown with their employees, but did not direct agencies to document lessons learned from how they planned, managed, and implemented the shutdown for future reference,” the report said. GAO’s recommendation for the future is that agencies dealing with a shutdown better document the impact. OMB declined to take a position on the recommendation.
Onward and Upward! How to live an uncommon life. Patience and Life: Practical Matters My wife gave me a fascinating book called “Leonardo’s Notebooks” by H. Anna Suh. The book is a rich collection of artwork and writings, arranged in three sections: Beauty, Reason and Art; Observation and Order; and Practical Matters. I’m delighted to borrow from the third section this morning, Practical Matters. Da Vinci possessed one of the greatest minds the world has ever known, yet his ability to point to simple truths made his brilliance tangible and personal. One of his statements stood out above the many others I’ve read this morning, both for its profundity and for its simplicity: “Patience serves us against insults precisely as clothes do against the cold. For if you multiply your garment as the cold increases, that cold cannot hurt you; in the same way increase your patience under great offences, and they cannot hurt your feelings.” Why is it that patience tends to “wear thin?” Why do we tend to lose patience at precisely the wrong time, only to regret it later, seeing the folly of our rashness in retrospect? True patience is not a passive state. In fact, patience is a dynamic state that requires preparedness, vigilance and a keen sense of timing. Preparedness, because he who is patient is always ready to do the right thing. Vigilance, because all things work out in season. And a keen sense of timing, because the right thing to do can only be done during a specific window of opportunity. Patience encompasses both rest and action. Trying to push when the timing is not right is a sign of impatience. Conversely, resting when action is called for is false patience. He who is patient is not controlled by the circumstances in which he finds himself, in fact, patience is never reactive, it is wholly proactive. Patience provides the state of of mind and heart that allows for sensitivity to the subtle elements of timing that most miss in their hasty and frenzied approach to life. So many of life’s miseries are the result of a misfire, like a poorly timed piston engine, and the natural power and wonder that would move through life naturally and harmoniously is released in awkward fits and starts, typically to the chagrin of all involved. Perhaps the experience of such a mis-timed effort was what caused someone long ago to shrug his or her shoulders and mutter, “That’s life.” Is that really life or is it the way we’ve tended to experience life? Perhaps it is more correct to say “That’s my experience of life.” Life really doesn’t deserve the bad reputation we have given it over the years. I am convinced that the argument that “life sucks” made by so many people in so many ways is specious. I once heard life described as “the hyphen between matter and spirit.” Life really is what you make of it. You cannot sit idly and expect the cosmos to deliver you a wonderful and fulfilling life, neatly packaged and just as you ordered it. You must oscillate between work and rest, compression and expansion according to the impulse of life in you. If you don’t feel sensitive to the timing, have patience. It will come. Look to release areas of tension, for in patience there is no tension. Perhaps the greatest reason why people tend to be impatient is that they are afraid of being hurt, terrified of some potential loss if they don’t take matters into their own hands according to their own timing. Fear not, for in true patience there is an inner strength that comes wearing the clothes of inner calm. Patience is not gritting your teeth, grinning and bearing it or holding back. It is poise and readiness, acting only when the timing is most propitious for a positive outcome. Patience is a practical matter. Thank you, Signore DaVinci! 6 Responses I think patience is more than just a virtue that a few really “together” type people have. It seems to me like a muscle that we all have but few understand how to develop it. Your post gives some good food for thought as to how it can be developed. Sensitivity sounds like a practical way to begin. I am just starting a new hobby this summer and it occurs to me that elements of myself can be developed in much the same way. Exploring, taking initial steps to experience, enjoying the process, delighting in my new found ability and staying with it as I become more adept. Thanks for such a clear information on this subject. It is one of the things most people lament not having. Wow, this article, especially the quote by Davinci, really came at a great time for me. I had never thought of patience in this way before. It’s something that can be applied to my life every single second of every day, and I look forward to seeing the outcomes that happen when I really apply this dynamic patience. Thanks Gregg, and Leonardo! If more tooke responsibility by saying “This is my experience of life” instead of “That’s life!” then we could stop giving life such a bad rap. Life is rarely any of the things people say it is when they use such expression. Amazing thoughts on patience! What a wonderful book for your wife to give you. My husband is no longer living but we had many wonderful years together sharing such musings. I ordered a copy of Suh’s book – it sounds like just the kind of thing that would have stimulated a lot of creative conversation between us. Enjoy the rest of your weekend!
Simson is considered one of the few people in the NSW seat with the profile to challenge former Nationals leader This article is more than 1 year old This article is more than 1 year old National Farmers Federation president Fiona Simson has been urged to run as an independent against Barnaby Joyce, most recently during a rural womens event in Canberra earlier this month. Simson, a farmer who lives in the seat of New England, is one of the few people in the northern New South Wales seat with the profile to seriously challenge the former National party leader. She attended the Rural Women’s Award on 15 October, where a number of people urged her to run against Joyce. 'Anyone but Nats': Rural figures come out against Barnaby Joyce and Nationals Read more The dinner was attended by influential rural women and past award winners, including Catherine Marriott, who made sexual harassment allegations against Joyce, which he has denied. The rural womens’ network has rallied around Marriott and a number of women have pushed back against the idea of Joyce returning to the leadership of the National party. Simson has also spoken out in support of Marriott since she made the allegations. The NFF asked Marriott to host its annual congress on the theme of “diversify” in the same week as the rural womens awards. The decision made it difficult for Joyce to attend either event and effectively cut him off from a key rural constituency. It is understood Simson is considering her options as her three year term as NFF president expires in November next year. The federal election is expected in May. Simson has already spoken about the numerous approaches from political parties over a career in politics but those conversations have also involved running as an independent. pip courtney (@pipcourtney) and the big question on the lips of many in Canberra this week was "will Fiona Simson run against Barnaby Joyce in the seat of New England?" https://t.co/wQC04rXrSm If she stands, Simson would be yet another high profile woman independent running against the Coalition in a safe seat; following in the tradition of Cathy McGowan in Indi, Kerryn Phelps in Wentworth and Rebekha Sharkie in Mayo. The Victorian elections are also marked by independent women candidates challenging Coalition MPs in rural seats. The New England area has a history of support for independent candidates both at a federal and state level, including Tony Windsor and Richard Torbay. Eight months after he stepped down following his relationship with a former staffer, the breakdown of his marriage and the harassment allegations, Joyce has become increasingly vocal. Last week said he would take the leadership if it was offered to him, while denying he was actively campaigning against McCormack. Asked if he would “carry any baggage” with women in rural constituencies should he return to the leadership, Joyce said last week that “I would certainly say I would have to do a lot of work. Barnaby Joyce: 'I would take Nationals leadership if it was offered' Read more “And I do that all the time. There is no one in [Parliament] that is purer than the driven snow and that includes me and I acknowledge I would have to do work and I would be working very hard and be working as respectfully as I could,” Joyce told the Conversation. “But I would also plead with people, don’t assume that an inference is the truth or a rumour is the truth. A rumour is a rumour and an inference is an inference and when people have investigated something and can’t find something, then respect that decision.” Joyce denied that he chose to avoid the womens’ awards though he said “I acknowledge it would have been absolute burley for media and I just want that circus to stop.” While the NSW National party investigated Marriott’s allegations, the party was unable to make a determination due to insufficient evidence.
Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity. The cytotoxic effect of sequence and dose of Tomudex (TX) and 5-fluorouracil (FUra) on an HCT-8 colon carcinoma cell line using a clonogenic assay was evaluated. Synergistic cell kill was obtained with 24 h of exposure to TX followed by 4 h of exposure to FUra. Marginal synergy was obtained with the same sequence but with a 5-day exposure to FUra. The reverse sequence, FUra (either 4 h or 5 days), followed by TX (24 h), resulted in less-than-additive cell kill. The synergistic effect was not due to augmented inhibition of thymidylate synthase, as determined by the measurement of thymidylate synthase activity by tritium release from [5-3H]2'-deoxyuridine. Surprisingly, an increase in intracellular levels of phosphoribosylpyrophosphate was observed after 24 h of exposure to TX, suggesting the possibility of an indirect effect of TX and/or its polyglutamates on purine biosynthesis. Moreover, we observed an increased formation of FUra nucleotides in the cells preexposed to TX, likely due to the increased intracellular levels of phosphoribosylpyrophosphate, that as a consequence led to an enhanced incorporation of FUra into RNA and increased cell killing.
The extracellular matrix is an integrated unit: ultrastructural localization of collagen types I, III, IV, V, VI, fibronectin, and laminin in human term placenta. The human term placenta is used extensively as a source of extracellular matrix components. To elucidate the tissue distribution and interrelationships of seven of these components, monospecific antibodies directed against collagen types I, III, IV, V, VI, fibronectin, and laminin were reacted with human term placenta and studied by light and electron immunohistochemistry. Type I collagen was the basic structural unit of human term placenta, present as 30-35 nm, cross-banded fibers, often in the form of large fiber bundles. Type III collagen was present as thin 10-15 nm, beaded fibers often forming a meshwork which encased type I collagen fibers. Types V and VI collagen were present as 6-10 nm filaments, often closely associated with types I and III collagen. Type VI collagen also coated collagen fibers of all diameters, enhancing their periodicity, providing a staining pattern often similar to that observed with anti-fibronectin antibodies. Fibronectin was present in both maternal and fetal plasma and throughout the stroma of the chorionic villus, as both free filaments and coating collagen fibers. Basement membranes contained laminin and type IV collagen, but no fibronectin. In summary, the non-basement membrane proteins studied often codistributed with type I collagen, between and apparently attached to fibers, suggesting that they may act as binding proteins, linking type I fibers and bundles, to themselves and to other structures.
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dataset_info: features: - name: text dtype: string splits: - name: train num_bytes: 590610851.0 num_examples: 100000 download_size: 312662856 dataset_size: 590610851.0 configs: - config_name: default data_files: - split: train path: data/train-*

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